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<entry dataset="TrEMBL" created="2016-03-16" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWV8</accession>
    <name>A0A0W4ZWV8_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_04336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="KTW32851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613331.1">
        <property type="nucleotide sequence ID" value="XM_019757848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWV8"/>
    <dbReference type="GeneID" id="30671608"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04336"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KTW32851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="89" mass="11105" checksum="F8E8E93CFFE70B54" modified="2016-03-16" version="1">MIKKIKLFYFKLFEYENHNLYNLCKNHFEVMKNRNLKLSMIQYDFTIFLEYWKLLFCENKIKLDVIINNSPKHMEIYYSLWIDIGKLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWX4</accession>
    <name>A0A0W4ZWX4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RAVE complex protein Rav1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_04325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="KTW32865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613343.1">
        <property type="nucleotide sequence ID" value="XM_019757837.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.A0A0W4ZWX4"/>
    <dbReference type="GeneID" id="19896041"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04325"/>
    <dbReference type="eggNOG" id="KOG1064">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NSHLTLW"/>
    <dbReference type="OrthoDB" id="342131at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022033">
        <property type="entry name" value="Rav1p_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12234">
        <property type="entry name" value="Rav1p_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="402"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="2">
        <location>
            <begin position="590"/>
            <end position="1233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KTW32865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1287" mass="149518" checksum="A07E1ABD337257D6" modified="2016-03-16" version="1">MPNISPGAPLASYHAFSAVVYNNRTFVAYASGTSVPIFINGKKIIQILSVEKEITAVAIDRRSGRICVSSKSNIYIFDITKKMEFSVRKCKNIDAKLNSIKWSLKLTFTINNETISTLSWGDRGEILIGGTCLNLYSSNIKDGAIIWSQKLSRPVVFAIISPDAKLIACISEADCFIKIWKKPDFHEPIESFKLVYLPHPKPITSIKWKKKSYNDQVINNILYSMSQDKILRIWTQENLPESYIFKLSYIIDVRNNTSLFEIPSNNLGEDSSCLIIDNNILTSSLQHIPKNSSNKEINKLINIKNKSADICLAFDNNGQVWAFAILAYNNGINSKIEIVPISSTKKSNLHISESLKHAEYFAIPASEQENIKGISPNYIKNELMFFPNSTPQKRKFNLQTTWTGHGNHINSLVKSPKNDILLSKTMDGTMIIWKIKYFNKSENLKKIFSLQLKDSPTHIIIFNEKNSIILNFKNISILEIRRKSANIIATCEDVPVDIILCFMQLKNPLNLSQNLLDETYFLAITATKKVWIWKLSKISEKENSKNINIEKIQEFSLFYESDLHLVLPINQIKRSSYFQKEIFITISVIGQLKIWSKKISKDGKLYILPEAESLETKILKPKIIKEFSKKLAIICQKGKELTIWDIRSLEFSEIEECRYYFSTESEISNLDWTCTKNSQLVLALCFKYKVILICQTSHNYENKQKSWFLFRSFDISSLTNNSIQHLIFLNNMTLIVGSKNQLFLYNKANDNVDTINIPHKTNEKYISPKNIMLLNTILPVYHPQFLEQLLLIGDIENVRNILINLYEILDSFEKNYAINKNRIEIKDSFLGIPIDVFLKKKKKKNQYDRKHLNYHQLFSTEDKNIETIDQIPFERLLSRINDCLLSYTITNLNTSEQHHLISLIKSIKNIELHKNSIDTNGIRYYLFFLKNLYLFNNEKVNISMKEAIWAFHSDSQETLLQLINQEYEKNFTYIQIHSSYCFFWLKDRKNLKLQMETLAYKKYLINDKNPEFCSLFYIALRKKNILLNLWKMATGHSNQKIMINFLSNDFSETRWKIAAQKNAFVLLGKHRYEYSAAFFLLADKLQNAVNICIKNLQDISLAIGISRVYEGDDSQIFKNLLRTYIIPDAIKFNDRWLACWAFWILGKIDLSIKSLVLPLTSLLEKNSKSIIPINYKKMFDGDPSLIILYKELKSKSSQIFKNPVISQYQEFKFILYVAHLYTYIGCDTLALNLIQGWNFENQFLSNYKKTYKDLYPKIPLNDHNNNTVLNTPSIIKEYESNLNTFHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWZ8</accession>
    <name>A0A0W4ZWZ8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_04288</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="KTW32901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613373.1">
        <property type="nucleotide sequence ID" value="XM_019757807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWZ8"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZWZ8"/>
    <dbReference type="GeneID" id="19896388"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04288"/>
    <dbReference type="OMA" id="NAAMIGC"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072670">
        <property type="term" value="P:mitochondrial tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="8">
        <location>
            <begin position="54"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KTW32901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="397" mass="44685" checksum="4D166FF7A0BFAD86" modified="2016-03-16" version="1">MIFGCRNYWDCLFPRKILRFYRELRILAIETSCDDTSVCLLEDDKNQGSVKVIYHKTERSLNENEKFGGIHPEVSIISHQKKLSRILKQVFDEHIRGQRNIDLIAATQGPGMVGSLSVGLNTAKGLSVALGVPLIGIHHMQAHSLTPRLINNGKFPEFPYLSLLLSGGHTLLIRSRSVIDHDILASTLDISVGDMIDKCARLLKVDWNGMMPGQALENWSKSYDTSTDTDTIWDLPDLLMKTPENQSKLAFSFSGLGSSVDRIVKKSSFTEFQLKSLARSLQISAFTHISHRLLLGLKKIDDYITGIVISGGVARNSFLKTILYTTLNNSPYKHLPLFFPPIELCSDNSAMIAWTAYEMYSLGYISDLSILPIRRWPINQLLELGKYIVYDKTSIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZX24</accession>
    <name>A0A0W4ZX24_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_04270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="KTW32917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613388.1">
        <property type="nucleotide sequence ID" value="XM_019757793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZX24"/>
    <dbReference type="GeneID" id="30671565"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04270"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KTW32917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="70" mass="8294" checksum="AA47420E33FC5172" modified="2016-03-16" version="1">MSYRLIKKVGLLSTISFTIFIIALNDNVICILIIYMNYIITLKCLKIGIRLFELRLLYIFKYELEMAKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7NHK8</accession>
    <name>M7NHK8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Maintenance of telomere capping protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_03495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875585.1">
        <property type="nucleotide sequence ID" value="XM_007877394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NHK8"/>
    <dbReference type="STRING" id="1069680.M7NHK8"/>
    <dbReference type="GeneID" id="19897182"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03495"/>
    <dbReference type="eggNOG" id="ENOG502QU4J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042692_0_0_1"/>
    <dbReference type="OMA" id="QWIHNIN"/>
    <dbReference type="OrthoDB" id="5594977at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018814">
        <property type="entry name" value="DUF5427"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265:SF1">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10310">
        <property type="entry name" value="DUF5427"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="44140" checksum="0B95337547C0C835" modified="2013-05-29" version="1">MSENKKDFMSLFDSIDKINFEKDTHDFPVENIQDEKTVLEFLDNISKKRPIEKCEETQEVEENVEKTGLLSENYVKNDSIDEMEKISKNSEETWFNGLLNNASFFVKQAEEKVKQFQQSEGKKIQKRMSQFIDIDTLGKLGEHFKSYSISSLSSTFNSVLNVVAPPISLHEILEIEIYHDLIFFPKIDNIVYSVFDEVLSQIENEDIVVQKGKKDTIFLEPSKEFCIFEGIDEAIRSAKYHIAPFLGSKKKQIRFSDSLTVYISCIYISIQAYSFNLENTLSDTKEEDLNKNEKMLCFVIHLNDPQYGIEFSVHSQALPIQWIHNINNKDSKLSEDYLDQINEWIEKTLQLSIGIVAQSYIEKRGNKNELLEDKPLSTNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7NIB1</accession>
    <name>M7NIB1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="7 11">3.13.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_03452</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.13.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="10 11">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.13.2.1" evidence="7 11"/>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875541.1">
        <property type="nucleotide sequence ID" value="XM_007877350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NIB1"/>
    <dbReference type="STRING" id="1069680.M7NIB1"/>
    <dbReference type="GeneID" id="19897139"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03452"/>
    <dbReference type="eggNOG" id="KOG1370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025194_2_1_1"/>
    <dbReference type="OMA" id="YIGVTVE"/>
    <dbReference type="OrthoDB" id="10007170at2759"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1480:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004005">
        <property type="entry name" value="PRK05476.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF0">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="13">
        <location>
            <begin position="193"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="159"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="224"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="301"/>
            <end position="303"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR08288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="435" mass="48156" checksum="AFB12881FD402449" modified="2013-05-29" version="1">MTLTHPYKVADISLANWGRKEIELAENEMPGLLSCRKKYGNSKPLKGARIAGCLHMTIQTAVLIETLVELGAEVTWSSCNIFSTQDHAAAAIAASGISVFAWKGETEEEYLWCIETQLTSFKNGKHLNMILDDGGDLTSLVHNKYPEYLENCKGISEETTTGVHQLYRMFKEGRLKVPAINVNDSVTKSKFDNYMGCRESLIDGIKRATDIMIAGKVAIVAGFGDVGKGCAKALRGMGARVIITEIDPIVALQASMEGYQVAVMEEIAYQGDIFVTATGCKDIICERHFEVMKNDAIVCNIGHFDVEIDVAWLKKNAVNVSNIKPQVDRYQMKNGRHIILLAEGRLVNLGCATGHSSMVMSMSFTNQVLAQIALWTAQEGQYPLGVHFLPKKLDEEVARLHLSKLDVKLTCLTPAQSLYLDIPIDGPYKNEHYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJ47</accession>
    <name>M7NJ47_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_03118</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60292"/>
            <dbReference type="Rhea" id="RHEA-COMP:15535"/>
            <dbReference type="Rhea" id="RHEA-COMP:15548"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.356"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875175.1">
        <property type="nucleotide sequence ID" value="XM_007876984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJ47"/>
    <dbReference type="STRING" id="1069680.M7NJ47"/>
    <dbReference type="GeneID" id="19896805"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03118"/>
    <dbReference type="eggNOG" id="KOG1079">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_452772_0_0_1"/>
    <dbReference type="OrthoDB" id="6141102at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140951">
        <property type="term" value="F:histone H3K27 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10519">
        <property type="entry name" value="SET_EZH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026489">
        <property type="entry name" value="CXC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045318">
        <property type="entry name" value="EZH1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041355">
        <property type="entry name" value="Pre-SET_CXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033467">
        <property type="entry name" value="Tesmin/TSO1-like_CXC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18264">
        <property type="entry name" value="preSET_CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01114">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51633">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CXC" evidence="8">
        <location>
            <begin position="413"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="7">
        <location>
            <begin position="535"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="664" mass="76870" checksum="9B9517175023262C" modified="2013-05-29" version="1">MDFEKIQFSEKINQVIQNAFIRFKLEHGEFFKNQLKIAQNTIKYTQDIQWSNNLDRNIINDSLISKADCSEKKINFYTMNFNSSSKTSKSIFQKCITIENIPGLPKYKENMSLRLNVIKNDEETLRFIPYIGEGNEDSDLNLHETFDIKIKIQSKEEILEMASDLSNILVKTISECGITLPMLYNYYLDSKTNIIVSQNFKEEWSLFLKHCKKNSTAKVTLGEKSYYILEIFTSSWNYYMPVELWKTMQWIDKTPKHHAREKTVILKPSSSDPLDSYSQLLCVFCYMNGCPYHDSFITRLPTLSLEKEEPYDKETPCSKTCILNISSFKDIPQSEWTSDEMSILASSVKVLNTNSKLSCLIALGLNKTCIEVSMKINDESFKDFFKNFWNINKIENFSKNNKTTNYQKVSTKRKRWTLYPDDCDKSGISTERTELKPCDHLGLCDENCPCVQNRVFCEKFCLCLDDCPRRWLGCLCKTNKCSTWACECVKWKRECDPDICIACDSAEALDPINRYNFNRLALMCQNVPIQQGLSCRLILGESNISGWGLFIGESVTADKFLGEYKGEIISHNESERRGKLYDKIGISFLFNLNKNHVVDATRMGNKFRYANHSRKNPNCFARVSLVNGTHRIGFYAIRDIKIGEEVSKYIFKLKVNNLFPLASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJD4</accession>
    <name>M7NJD4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Decapping nuclease</fullName>
            <ecNumber evidence="6">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66928"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:172876"/>
            <dbReference type="ChEBI" id="CHEBI:172877"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:66929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60880"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:60881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78683"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78684"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="6"/>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874938.1">
        <property type="nucleotide sequence ID" value="XM_007876747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJD4"/>
    <dbReference type="STRING" id="1069680.M7NJD4"/>
    <dbReference type="GeneID" id="19896587"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02900"/>
    <dbReference type="eggNOG" id="KOG1982">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024877_4_1_1"/>
    <dbReference type="OMA" id="ACTPYEN"/>
    <dbReference type="OrthoDB" id="5853397at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110103">
        <property type="term" value="C:RNA polymerase II termination complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140432">
        <property type="term" value="F:5'-hydroxyl dinucleotide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019003">
        <property type="term" value="F:GDP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990174">
        <property type="term" value="F:phosphodiesterase decapping endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110152">
        <property type="term" value="F:RNA NAD+-cap (NAD+-forming) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000448">
        <property type="term" value="P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904595">
        <property type="term" value="P:positive regulation of termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030846">
        <property type="term" value="P:termination of RNA polymerase II transcription, poly(A)-coupled"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="7">
        <location>
            <begin position="2"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="318" mass="37246" checksum="A63CD5EA54EEAF7E" modified="2013-05-29" version="1">MYYYPPALGADLSNGFDKRIERDETINEHLDGLLLSLCEYERQHGFQRTFVDILTWRGILTRFLCTPFDRCTAWAVNIVRFQNTIFIEDHLETISLPTEQEARMRFWGYKFETLSTLPDTWDNCSRDQIEHRNDIIVNNHIQYCSVVRTSLDKTTLVMGGEVDCAWDAKPDPPENPVPHYVELKTSRSLTTHSARKTFELHKLLKFWAQSFLLGVPRIIVGFRTDDGYLESIEEYKTQTIPSKTSSFNGNLALAWMSQLFYFLKEKIPDQEGVWRLCYTQNADIVQLYKIESKGYGFLHPQFISWRKINIQKFNDPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJP9</accession>
    <name>M7NJP9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Protein transport protein BOS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_02620</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">SNARE required for protein transport between the ER and the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 12">Belongs to the BOS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874639.1">
        <property type="nucleotide sequence ID" value="XM_007876448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJP9"/>
    <dbReference type="STRING" id="1069680.M7NJP9"/>
    <dbReference type="GeneID" id="19896311"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02620"/>
    <dbReference type="eggNOG" id="KOG3251">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078260_1_0_1"/>
    <dbReference type="OMA" id="FCWLVIH"/>
    <dbReference type="OrthoDB" id="158360at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027027">
        <property type="entry name" value="GOSR2/Membrin/Bos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF1">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028865">
        <property type="entry name" value="Membrin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="67"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR08833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="226" mass="26847" checksum="230DD10D3403922E" modified="2013-05-29" version="1">MNIFYNQALRQTQNLKKDLNSFQSSITDNISSTLPLQGQITVSLNSLSRTIHEYETMSKKEMNIEKQEKAISRVKEFKKQYSELKEKFDDLKMKHKQMEHLNQKNELLERRFHTNTLPENPYEHVKSDNLNEQRNFNLSTSDFLKNTDSQLDDFLGRGQAILNDLIEQKLYIKRVQREIYNVGNILGLSKSTIKFIERRILQDKILFWGGVISTLFFFYLIYHWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJX3</accession>
    <name>M7NJX3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02704</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874729.1">
        <property type="nucleotide sequence ID" value="XM_007876538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJX3"/>
    <dbReference type="STRING" id="1069680.M7NJX3"/>
    <dbReference type="GeneID" id="19896395"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02704"/>
    <dbReference type="eggNOG" id="ENOG502QR13">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010811_4_1_1"/>
    <dbReference type="OMA" id="PYNYQYE"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="10">
        <location>
            <begin position="279"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR08923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="674" mass="78323" checksum="206546A6863D6B24" modified="2013-05-29" version="1">MTRNYWFDEALPDYYPQNYENNWNVRAPRMHRPLPPIPCHLETQYQEQCENIVPSQQQYLYDQNYHGFRNEDVSFPRRRIVSHGDYSEDETVYQKQEESVNHCDYNSFVPYTSRNMTGDIYEDYKDMNYMVLDYKRKSYMNYSQKSNNDYCYEAGRNEYEESKSEKEDKVSSNIQTGTIKRDITNNLDILWDPNIAEPDDYLHNPATKEKRKDYCIFTKRGILNIGSLVILIFGIISFFIGYPILLYARKIYEDIHRCPDCIKTLPIDLLGATRGLIDPDTPEEFYELKNSDGKVYKLVFSDEFNKDGRTFYPGDDQFWEAVDLHYWSTLSLEWYDPDAITTNGGFLEIRLDAFRNHDLNYRSGMLQSWNKLCLKGGIIEASISLPGRGDTSGLWPAFWMMGNLGRPGFGASTEGTWPYSYDNCDIGITPNQSDHSGFSFLPGMKLPGCTCPNSDHPSPGKGRGAPEIDIIEASVDLSLHIGEASQSVQFAPFDDNHRPNYDHMAIHNTEKTHINPYRGNVFQQTFSCITYLNNEWYNGYKFQTYGLEYKPGKKGYIEWFIGDQATWKMKSESVGPNGNIGQRLISEEPMAIIINLALSESFSKIEWGKLQFPAIMRIDWVRIYQEESLITCDPPGYPTTKYIKDHPIAYYNNNVTTWNNTGYEWPKNRLMHKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NKJ3</accession>
    <name>M7NKJ3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED6</name>
        <name evidence="10" type="ORF">PNEG_02503</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874513.1">
        <property type="nucleotide sequence ID" value="XM_007876322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NKJ3"/>
    <dbReference type="STRING" id="1069680.M7NKJ3"/>
    <dbReference type="GeneID" id="19896195"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02503"/>
    <dbReference type="eggNOG" id="KOG3169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1062472_0_0_1"/>
    <dbReference type="OMA" id="ERPPFLW"/>
    <dbReference type="OrthoDB" id="344220at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="entry name" value="Mediator complex, subunit Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="MED-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="186"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR09163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="232" mass="26690" checksum="CEB4098017BC183E" modified="2013-05-29" version="1">MIDLSVIAWRMPEWITAYGRLCTDNVLDYFSQSPFYDRHSNNEVLKMQTQFNTLGDFHGHLKKMRGIEFVISAEKDPDIWVIYKQHRSSENDASVLAAYFVANESIYMAPSIHSVISSRMLNIILSLRQALASVHNLHHFSSITEYSYSAPEVPSKEMPIHNIKANQHMRKALNDAIREKLYDMTQSKDETKQELQENSSDDHFKAKLDPTSTIVKKKKKTKKSESPASPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLI3</accession>
    <name>M7NLI3_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin-conjugating enzyme E2 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_03497</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875589.1">
        <property type="nucleotide sequence ID" value="XM_007877398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLI3"/>
    <dbReference type="STRING" id="1069680.M7NLI3"/>
    <dbReference type="GeneID" id="19897184"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03497"/>
    <dbReference type="eggNOG" id="KOG0416">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_7_1_1"/>
    <dbReference type="OMA" id="QQWSAVY"/>
    <dbReference type="OrthoDB" id="269518at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23797">
        <property type="entry name" value="UBCc_UBE2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000061">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="3"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="182" mass="21084" checksum="1C4EFAAD5D660872" modified="2013-05-29" version="1">MSSPRRRIETDVMRLLMSDYEVTLINDNMQEFYVQFRGPEETPFTGGIWKVHVELPDQYPYKSPSIGFMNRIFHPNIDELSGSVCLDVINQTWSPMFDMINIFEVFLPQLLRYPNPCDPLNGEAAALLIREPKTYEMKVRDYVSRYATKEIMETVMVESSENEEMSSVGSFNSEDPAAEMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLL3</accession>
    <name>M7NLL3_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Phosphoribosylamine-glycine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PNEG_03470</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the second and fifth step in the 'de novo' purine biosynthesis pathway; contains phosphoribosylamine--glycine ligase (GARS) and phosphoribosylformylglycinamidine cyclo-ligase (AIRS) activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the C-terminal section; belongs to the AIR synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the GARS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875558.1">
        <property type="nucleotide sequence ID" value="XM_007877367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLL3"/>
    <dbReference type="STRING" id="1069680.M7NLL3"/>
    <dbReference type="GeneID" id="19897157"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03470"/>
    <dbReference type="eggNOG" id="KOG0237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005361_1_0_1"/>
    <dbReference type="OMA" id="EVMQACC"/>
    <dbReference type="OrthoDB" id="2018833at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000006">
        <property type="entry name" value="Phosphoribosylamine--glycine ligase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000006">
        <property type="entry name" value="phosphoribosylamine--glycine ligase, chloroplastic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000001">
        <property type="entry name" value="Phosphoribosylformylglycinamidine cyclo-ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000018">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000007">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="entry name" value="Phosphoribosylglycinamide synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520:SF12">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01209">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="18">
        <location>
            <begin position="110"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMR08026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="783" mass="85919" checksum="CD4ED4902C438668" modified="2013-05-29" version="1">MKLLIIGNGGREHALSWRLSKSPRVEKIFVAPGNGGTNGLYGIVENVEIGPLEFEKLVKFAVSNDIDLVIPGTEVPLVAGAEEYFRKAGIYFFGPSKKAAQMEGSKAFSKDFMKRHNIPTAKYKNFTSYELAKEYILQVDYDVVIKASGLASGKGVIVPESKSHALTSLHEIMENKIFGIAGDEVVIEERLIGEELSILAFSDGYTIKLLPPARDYKRLYDGDKGPNTGGMGCYSPSISTLSLLEQIRKEILQETIDGMRKEGFPFVGLLFTGIMLTSDGPKVLEYNVRFGDPETQTVLPLLHEDTDLLEIILACIERRLDFVQLHINPLFSVCIVLAAKGYPYSYEKEKLIDIGTIGDEAIVFHSGTAISESKELVTTGGRILSISATGITLEEAAKNAYKNIKSIFFENMFNRNDIAYKECDTNKKKLKDIVTYLSSGVSIDTSNNFLSIIKSKIQTTKRLGSDAIIGGFGGIFDLKKLNYKDPLLVSTIDGIGTKIKIAQAINRHDIIGIDLVAMNVNDLIVQGAEPLFFLDYYACRKLDISNATSFIDGICNGCIMAGCALIGGETAEMPGIYYNKDFDSAGAAIGIVERKNLLPSFEIMKSGDIVLGLGSSGLHSNGFSLIRKIIEKSGLYYNDPAPWDPSTTIGLSLLTPTRIYVKSLLNLVKKGVIKGMAHITGGGFIENIPRILPDNLMCEIDATSWELPKVFSWLKKAGNVPINDLSRTLNMGIGMVIIVDIMNVSEVLTELKNMGENVYNIGNILNRTSQHPKCLLKNLDAWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NM25</accession>
    <name>M7NM25_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytosolic Fe-S cluster assembly factor CFD1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01904</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873879.1">
        <property type="nucleotide sequence ID" value="XM_007875688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NM25"/>
    <dbReference type="STRING" id="1069680.M7NM25"/>
    <dbReference type="GeneID" id="19895598"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01904"/>
    <dbReference type="eggNOG" id="KOG3022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024839_0_1_1"/>
    <dbReference type="OMA" id="FEPKEFP"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904564">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly scaffold complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001119">
        <property type="entry name" value="Iron-sulfur cluster carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF19">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="31848" checksum="A62EC5182AE0F19B" modified="2013-05-29" version="1">MIYLDSSALKSVKHILLVLSGKGGVGKSSVSVQLSLSLLLMGFRVGLLDIDLTGPSIPYLLGLEGCHIYQSSSGWVPLHLFINEPSTEMKVVSIGFLLPSRGDAVIWRGSKKTSMIQQLLSHVEWGVLDFLIIDSPPGTGDEQIAVTETLHAMNCIKKSHVVVVTTPQEVSLVDVRKGINFCRKAGLNIYGIIENMSTYICPHCSTSTDIFSSGGGEELSESYQIPLLGKIPLDSTLADLIKCQPASDLNTSEKIPLSELVDESNWDLPERYKKCTLYPLFKEIVNKILEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NM84</accession>
    <name>M7NM84_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Translation machinery-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01947</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2 4">Interacts with the 40S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="4">The SUI1 domain may be involved in RNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DENR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873924.1">
        <property type="nucleotide sequence ID" value="XM_007875733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NM84"/>
    <dbReference type="STRING" id="1069680.M7NM84"/>
    <dbReference type="GeneID" id="19895641"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01947"/>
    <dbReference type="eggNOG" id="KOG3239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073511_0_1_1"/>
    <dbReference type="OMA" id="EVFEIDM"/>
    <dbReference type="OrthoDB" id="277199at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11607">
        <property type="entry name" value="DENR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050318">
        <property type="entry name" value="DENR/SUI1_TIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046447">
        <property type="entry name" value="DENR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005873">
        <property type="entry name" value="DENR_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048517">
        <property type="entry name" value="DENR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01159">
        <property type="entry name" value="DRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789:SF0">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21023">
        <property type="entry name" value="DENR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="SUI1" evidence="5">
        <location>
            <begin position="106"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="195" mass="22844" checksum="AB221E758487769F" modified="2013-05-29" version="1">MHEIESQESDIFSQVVKKAKDVIYCGVCSFPPEYCEYGNFSGKCMEWLKENHMELYIRLYSQDPLIIEKQDIIFEEKEKIDESNKIRTKEETKGLKKTKKNTISKVLIKRVERNKRKYVVIVQGLELYGIDVKKASKLLGKKFATGSSVTKNVCDIDELVIQGDHIDEIYNYILETYPEIPEENIECFKDKQKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NML3</accession>
    <name>M7NML3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SPIN90/Ldb17 leucine-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875264.1">
        <property type="nucleotide sequence ID" value="XM_007877073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NML3"/>
    <dbReference type="STRING" id="1069680.M7NML3"/>
    <dbReference type="GeneID" id="19896888"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03201"/>
    <dbReference type="eggNOG" id="KOG4035">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017272_0_1_1"/>
    <dbReference type="OMA" id="FMEDIHI"/>
    <dbReference type="OrthoDB" id="445362at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030125">
        <property type="entry name" value="SPIN90/Ldb17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018556">
        <property type="entry name" value="SPIN90/Ldb17_LRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357:SF1">
        <property type="entry name" value="NCK-INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357">
        <property type="entry name" value="SH3 ADAPTER PROTEIN SPIN90 NCK INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09431">
        <property type="entry name" value="SPIN90_LRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPIN90/Ldb17 leucine-rich" evidence="1">
        <location>
            <begin position="115"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="342" mass="41432" checksum="4C2A18A65BAD944A" modified="2013-05-29" version="1">MFISNKDYTRYQLVIMINQEDKLQYFYILYWLLFFDAQSYPQTYKLIKDKGSFQSLINTIWKHFQEFPELHKLGLKLLYEICRVHQLTSEELFFIHEEFLCFIFELIEKNTYYEDPYTLSSIKLILIINEQYIIKSLPSHLQHSSYETLRSIENESPMNLVMDILKKKGSLYKTFGENIIFILNREKDIFLQFLILKQLYLIFTTKETLEYFYTNDLRVLVDVFIRKLYNLPENNKKLYHAYLRVFYYLLKNTQLKNPPYYKQDQLQKLFQALKESIKYQHIKPANSITEKLLLRCIKISWIKNNELENDILFSTNWNNESNSSFIEASTNDHYIFSNSNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NML6</accession>
    <name>M7NML6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine-threonine kinase receptor-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_03206</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875269.1">
        <property type="nucleotide sequence ID" value="XM_007877078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NML6"/>
    <dbReference type="STRING" id="1069680.M7NML6"/>
    <dbReference type="GeneID" id="19896893"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03206"/>
    <dbReference type="eggNOG" id="KOG0278">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_6_1"/>
    <dbReference type="OMA" id="DGFYGLW"/>
    <dbReference type="OrthoDB" id="408728at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF13">
        <property type="entry name" value="SERINE-THREONINE KINASE RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="95"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="138"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="260"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="302" mass="33988" checksum="0C9D77DDCD3FD35A" modified="2013-05-29" version="1">MTENSSYSSFTSETELRMLPLTCSGHTRPVMHLSFSHGNSMLRDGITGDWIGTFLGHKGATWSSRFNKDADKAVTGSADFSAKVWDTYTGNMLQSFSHEHIVRSVDFSYNSKEIVTGGHEKRIRIFSLNSPLTPIFDLLGHKGTIKNVTWMDNVIISSGDDEKVRWWDLRMLKEVNTFDAGEFVTNSEKSLGEEYLLVVAGKKIFFVDFKTQKSVKTIVTEYDLSSVSLHPEKTKFVTGGSSQPWVRVYDFKTEKQLNVYKGHHGPIHCVSFSPDGGLYATGSEDGTIRLWKSQQGPYGLWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMN5</accession>
    <name>M7NMN5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Flap endonuclease 1</fullName>
            <shortName evidence="15">FEN-1</shortName>
            <ecNumber evidence="15">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PNEG_03228</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
            <location evidence="15">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
            <location evidence="15">Nucleoplasm</location>
        </subcellularLocation>
        <text evidence="15">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14 15">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="15"/>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875294.1">
        <property type="nucleotide sequence ID" value="XM_007877103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMN5"/>
    <dbReference type="STRING" id="1069680.M7NMN5"/>
    <dbReference type="GeneID" id="19896915"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03228"/>
    <dbReference type="eggNOG" id="KOG2519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032444_2_0_1"/>
    <dbReference type="OMA" id="MGIPWVQ"/>
    <dbReference type="OrthoDB" id="1937206at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051908">
        <property type="term" value="F:double-stranded DNA 5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045145">
        <property type="term" value="F:single-stranded DNA 5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032042">
        <property type="term" value="P:mitochondrial DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09907">
        <property type="entry name" value="H3TH_FEN1-Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000009">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000003">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 15" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 15" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 15" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="18">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="17">
        <location>
            <begin position="147"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMR08391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="379" mass="43327" checksum="19591A365714B473" modified="2013-05-29" version="1">MGIKHLRQLLEEHASSCIKLNNIDHYFGRKVAIDASMSIYQFLIAVRQQDGQQLMTETGETTSHLMGIFYRTLRMCDNGIKPCYVFDGSPPKLKSGELAKRLERREEAVKLHSEAKEIGSIEDINKFSKRIIRVTREHNEECKKLLKLMGIPCINAPCEAEAQCAALAKSGKVYAAASEDMDTLCFSTPILLRHLTFSEQKKEPISEVNLEKALKELYMPLEQFVDLCILLGCDYCEPIKGIGPKRALELIREYKSLDTFISSADGSKYQIPENWPYKDARDLFLNPDITNPETLELKWESPDAKGLLEFLVKEKGFNEERVNNGILRLEKALKSSQQVRLDSFFKVIPKLHEATSVEKRKTEENTHANKKNRTNKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMQ5</accession>
    <name>M7NMQ5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TBP-associated factor 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_03247</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875314.1">
        <property type="nucleotide sequence ID" value="XM_007877123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMQ5"/>
    <dbReference type="STRING" id="1069680.M7NMQ5"/>
    <dbReference type="GeneID" id="19896934"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03247"/>
    <dbReference type="eggNOG" id="KOG1142">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_645771_0_0_1"/>
    <dbReference type="OrthoDB" id="2193432at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07981">
        <property type="entry name" value="HFD_TAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000011">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037794">
        <property type="entry name" value="TAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264:SF21">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 12" evidence="8">
        <location>
            <begin position="320"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00075089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="425" mass="48103" checksum="BF2737FA4D5EE9AF" modified="2013-05-29" version="1">MSQLQDLQAQITKYEQAAQQAGLQTPQGQALYQNVCRLKQKLLTIQSGSTINANVDILKPQGLRQGTAPVNHNVKQALEVQSHLQQTTQHFVKAISELKEQLTKIKAELSNPNITQREKEELEKEHNEKVAALNTYHMHIQKATQQFHQMQQMQSIQGQENPIKTGTMHQTNPMMQKVQTNQVAMNMALQQRASMQQMNPIAIQQQQISQANKNKETVAPSIQQFRQNPVNIPRPPVQPATNLPFQPVSGQIVQNSNVHTSFEKMPPIPEVINVKPPVPMSIPPSRPTLTSGYTTTPFMSTPGISKPPQYDIDNGNRILSKRKLQELVKQINPDERLDPDVEELLLEVADEFVESVVSFACRLAKYRKSDTLDVKDVQLHLERNWNIRIPGYTSDEIRSVRKNIPCQAYQQKQNAIATAKSMSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMU0</accession>
    <name>M7NMU0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glycine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diadenosine tetraphosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_03028</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 ATP + H(+) = P(1),P(4)-bis(5'-adenosyl) tetraphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34935"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875079.1">
        <property type="nucleotide sequence ID" value="XM_007876888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMU0"/>
    <dbReference type="STRING" id="1069680.M7NMU0"/>
    <dbReference type="GeneID" id="19896715"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03028"/>
    <dbReference type="eggNOG" id="KOG2298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015515_1_2_1"/>
    <dbReference type="OMA" id="MEMQYFV"/>
    <dbReference type="OrthoDB" id="57698at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00858">
        <property type="entry name" value="GlyRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.200:FF:000001">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000004">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000158">
        <property type="entry name" value="Glycyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000010">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="194"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR08547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="656" mass="75383" checksum="9E76A9247E5D1F18" modified="2013-05-29" version="1">MSIKSENPGFCRSRLEELLKKRFFYCPSFELYGGVSGLYDYGPPGMALEQNILEIWRKHFVHEENMLEIGTSIVTPHEVLETSGHVYKFRDWMCKDPSTGEIFRADHLIKEILKERIKKGLESGLGCKDMSRDACGERYDKFDSCLNEIKQYESILSQIDNYDDKGLSRVIEEHDIRNPQTNVRVEGPVAFNLMFATEIGPTGNMTGYLRPETAQGQFLNFNKLLEFNNAKMPFASVVVGKSFRNEISPRSGLLRVREFTMAEIEHYVDPLNKDHKRFDEVENVKMKFLTREIQMSGKEEIIEMTVGEAVFRGILDNTTLAYFLARIHLFLIKIGVNKNKLRFRQHMRNEMAHYASDCWDAELLTSYGWIECVGCADRAAYDLTVHSDKTKEKLVVRELLSKPMEVKEWVVTVDKKKIGPLLKKDLKVVEQAISSWSNEDKIRYRDQAVSEGKIVVKVADGRQFEIPSSLFTIEQVKKTISVREYIPNVIEPSFGIGRILYSLIEHSYWIRSDDIDRCVLSFLPIVAPVKCLLVPLSNNSAFDPIIDKLSSELRRLGISYKVDDSSAAIGRRYSRNDELGTPFGITVDFQTVNDGSLTLRERDTTKQIRASEKEILKVVKELSEGLISWDDVLKDFPIFNKQNTDTPEITDLYTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMV5</accession>
    <name>M7NMV5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycerophosphocholine acyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_03289</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875364.1">
        <property type="nucleotide sequence ID" value="XM_007877173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMV5"/>
    <dbReference type="STRING" id="1069680.M7NMV5"/>
    <dbReference type="GeneID" id="19896976"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03289"/>
    <dbReference type="eggNOG" id="KOG2895">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018994_1_2_1"/>
    <dbReference type="OMA" id="WKRRVPT"/>
    <dbReference type="OrthoDB" id="406287at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106158">
        <property type="term" value="F:glycero-3-phosphocholine acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036151">
        <property type="term" value="P:phosphatidylcholine acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090640">
        <property type="term" value="P:phosphatidylcholine biosynthesis from sn-glycero-3-phosphocholine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021261">
        <property type="entry name" value="GPCAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201">
        <property type="entry name" value="OS01G0585100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10998">
        <property type="entry name" value="DUF2838"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR08461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="399" mass="47325" checksum="FCFAD5DB39187EAC" modified="2013-05-29" version="1">MNSDDISQTQSQRKKLSLSDYIGDDDLEFSILTFFGVFDSISNVPIKTLGNLNRHVRKKRDEFRENKVRPLQKKVDKELEKIKGRVTDKVDKLQRKWVDGSMIRTRNKVAFVLGVGNVFFSALLIGMSPQHLHLWYSVQILYFMPLRYITYHRKGMHYFIADLCYWVNMMLLLYLWVFPSSKFLFVSTYFLSFGSLSWAIIAWKNSLVFHSMDKVTSLFIHIFPPTVLHTIIHIVPIEYTYKRFPVLEELTDIDIFPAFIATSIAYFIWQALYYIFIQVRRREKISAGRPTSFTWLLKSYSNTWIGKLMLKLPEPTRPFAFMAIQYMYTLITMAPCPWWYSHKKFSTIFLSSLFAWSVWNGASYYVDVFGRRFQKELEDLRREVSTYENFNVLYPSKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN45</accession>
    <name>M7NN45_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873322.1">
        <property type="nucleotide sequence ID" value="XM_007875131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN45"/>
    <dbReference type="GeneID" id="19895084"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01387"/>
    <dbReference type="HOGENOM" id="CLU_209338_0_0_1"/>
    <dbReference type="OrthoDB" id="437973at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039715">
        <property type="entry name" value="ZCCHC10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491">
        <property type="entry name" value="ZCCHC10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13917">
        <property type="entry name" value="zf-CCHC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="61" mass="7147" checksum="2117102810B85B12" modified="2013-05-29" version="1">MKKATFSSKSSSNAQCQKCLKHGHWTYECKNPVIVYKSRPTRTQQLKNIELSKENKKDQFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN91</accession>
    <name>M7NN91_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_02875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874912.1">
        <property type="nucleotide sequence ID" value="XM_007876721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN91"/>
    <dbReference type="STRING" id="1069680.M7NN91"/>
    <dbReference type="GeneID" id="19896562"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02875"/>
    <dbReference type="eggNOG" id="ENOG502S0NF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123430_0_0_1"/>
    <dbReference type="OrthoDB" id="5552418at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="157" mass="18055" checksum="42F273D19B79C3EE" modified="2013-05-29" version="1">MDRSISSGSVRFESQDVSGDVEKDKIQTMILKTVVEISGSRWNDASRILWEMTNWLVNKVIHEGEAINITLGAWHSLNEAWLYFLCRTGEEIKTNTCHPSITEVHLEMLGQDIIGWCDQLEKYGLVDYEMGFWEERILEVMRYVLTLLKARKVGAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M7NND6</accession>
    <name>M7NND6_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_03107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875163.1">
        <property type="nucleotide sequence ID" value="XM_007876972.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NND6"/>
    <dbReference type="GeneID" id="19896794"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03107"/>
    <dbReference type="HOGENOM" id="CLU_1778271_0_0_1"/>
    <dbReference type="OrthoDB" id="5306529at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="146" mass="17724" checksum="C856B7779D954B0E" modified="2013-05-29" version="1">MENIQEVPNEQELETWEEKELYMIEMLHSLTLKVKVKKMEAKLYRKREFDLQHYLSNTPCEDLSQCEWQLSLLKLMKLRQKNDQICQEIKWYQGQIDTWKAELSDLRLHKLKSRGFMQWLKHLSDKSPFMCRKYRSQTELPGITGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNG1</accession>
    <name>M7NNG1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CTLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873440.1">
        <property type="nucleotide sequence ID" value="XM_007875249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNG1"/>
    <dbReference type="STRING" id="1069680.M7NNG1"/>
    <dbReference type="GeneID" id="19895196"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01500"/>
    <dbReference type="eggNOG" id="KOG0293">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_25_1"/>
    <dbReference type="OMA" id="GHISGCV"/>
    <dbReference type="OrthoDB" id="972532at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054080">
        <property type="entry name" value="TPR1-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051350">
        <property type="entry name" value="WD_repeat-ST_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838">
        <property type="entry name" value="WD REPEAT PROTEIN 26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23627">
        <property type="entry name" value="LisH_WDR26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21889">
        <property type="entry name" value="TPR1-like_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CTLH" evidence="4">
        <location>
            <begin position="80"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="251"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="293"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="335"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="477"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="502"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR10228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="552" mass="63409" checksum="7D4C7C1DCA58708E" modified="2013-05-29" version="1">MKQEKINSDSNSNLSLKNDIGNQIDNDFVISDIHDEKKELLKNHPIEKEEIIRLILQTLKDFGYKSSVSHLEQESGFSVESTHVLQFRKSILTGDWKHAEELLSFLYINEEVPTNILFYLRQQKFLELLEEKKMPEALSVLREELSPLDYNKERLHFLTSLIMSSSVNDLKRRASWDGANGISRQKLLKQISKYISPTLMIPEKRLINLLIQAKNYQISQCLYHTDSNFSSLLSDHHCEKDQFPNTVIKVLRDHTDEVWCTRFSHNGKYLASASKDSTAIIWNLQTYEPLYILKEHEKPVIYVDWSPNDELILTCGQDHMAKLWEVKSGTCIKTITHHKDFVTSCSWLPDGSGFITASLDMEVILWNIDGIIIHQWKGSRVYDLAVTPDGKKFIAGGTEKMLHVYNLLNRTLEFSFLMQSDLTCVSISKDSKFAIINVSSQEVYLWDLEKMQVVKKYAGQHQGNYIIRSCFGGAQENFILSGSEDSQVYVWHRENGSLIETLKSHKGTVNSVSWSPINPVMFASAGDDHTVRIWAKSSTLSKDKVYDDILLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNP8</accession>
    <name>M7NNP8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02662</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874683.1">
        <property type="nucleotide sequence ID" value="XM_007876492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNP8"/>
    <dbReference type="STRING" id="1069680.M7NNP8"/>
    <dbReference type="GeneID" id="19896353"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02662"/>
    <dbReference type="eggNOG" id="KOG1541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055194_0_2_1"/>
    <dbReference type="OMA" id="WIQEKKE"/>
    <dbReference type="OrthoDB" id="2877at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000017">
        <property type="entry name" value="probable 18S rRNA (Guanine-N(7))-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039769">
        <property type="entry name" value="Bud23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022238">
        <property type="entry name" value="Bud23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734:SF0">
        <property type="entry name" value="18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12589">
        <property type="entry name" value="WBS_methylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="9">
        <location>
            <begin position="55"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal" evidence="10">
        <location>
            <begin position="216"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR08877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="31242" checksum="53450BB04AD1B517" modified="2013-05-29" version="1">MTRPEHQAPPHIYYNEAEAKKYTSNSRTQIIQAEMTLRSLDLLNLPEKKSCFLMDIGCGSGLSGEILDQDKHIWVGMDISPWMLEAALKRDNEGDLMLSDIGHGLPFRGGCFDGAISISVLQWLLNADTSSSNPYQRIMRLFSTLYSCLIRGARAVFQFYPETDQSISIITSLANKCGFSGGIVIDYPDRKKAKKYYLVLQAGGGTNMTIRNIGSNQAPILMSHTSQRSKSSKQEKAKIKNTKEWILRKKEKYRKYKDNIPRDSKFTARKRRPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP65</accession>
    <name>M7NP65_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874863.1">
        <property type="nucleotide sequence ID" value="XM_007876672.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP65"/>
    <dbReference type="STRING" id="1069680.M7NP65"/>
    <dbReference type="GeneID" id="19896517"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02828"/>
    <dbReference type="eggNOG" id="ENOG502S590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_664144_0_0_1"/>
    <dbReference type="OMA" id="ESAMAHW"/>
    <dbReference type="OrthoDB" id="5440at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="414" mass="48495" checksum="F7EEAA27EE40D794" modified="2013-05-29" version="1">MGQLTKESILKLYQEFRQAPSQSIFSDQCILTYVTTCIRFSGSKNILLQLSEYQTHIKLKEEIINLHVTGNSIVSEVFLDIEFINGPAWLVPGLDDNFYIDRKVQLPHIYIMEFDEDEKISSIRVFWDQATILKQLEVFGSRKQAFPIKLGKEQHYFIKNKDIDSSNLSYSKEKQQQVSKKLSLFEPYEEPSREFHRNPVRPRSPTRPIQRPYEDLFVVKGTPISVKPPKASQKIHNVSKINSILFNEHEESNQQKSNDLKKDPKYTHFEFSTPTEKELEEERLAILAKAKKGVALRTMSRNWDEFENTPVSQCKQDASNQMLENTELDQEKYVPLNTRSYHENQLHFSFSNDSPTENSPVRVIQNEKYFQPKYSIFDYSSSEKDQDQNTNIEKADTITRLERDMNAKWSFGDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPX4</accession>
    <name>M7NPX4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carnosine N-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02262</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnosine N-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874251.1">
        <property type="nucleotide sequence ID" value="XM_007876060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPX4"/>
    <dbReference type="STRING" id="1069680.M7NPX4"/>
    <dbReference type="GeneID" id="19895955"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02262"/>
    <dbReference type="eggNOG" id="KOG2798">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030612_1_2_1"/>
    <dbReference type="OMA" id="EFWVAKK"/>
    <dbReference type="OrthoDB" id="978at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030735">
        <property type="term" value="F:carnosine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF6">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="363" mass="42401" checksum="F71ED2E78039AE6C" modified="2013-05-29" version="1">MDEDEEQVIADTLEAFKRYGEIMELKINIRRNVFRSLKKEDQMQLVEFEEHLNKIEEAVKINCKLANDIEKIGRSQFLSGKKYKESRSLKMGYMDKVLTTIKQFWRDWSKDGMAERDKSYKPIIDEIELKFMDIPINDRKKINILVPGAGLGRLPFDIALKGFSVQGNEFSYFMLISSFFLFNYLESSNKYFLFPFIHTFSNHRTNEDLLYKCTIPDINPRSVIFSGSNFSTSIGEFTEVYSQRSMESFFDVIATCFFIDTAPNIISYIKTIWHSLKPGGFWINLGPLLWHYEKDACEKESSEDNIPACSIELTLETLIQLIKNSGFEIDKRETINTTYVGNPCSMLKYIYESEFWVAKKKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ20</accession>
    <name>M7NQ20_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytidyltransferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874306.1">
        <property type="nucleotide sequence ID" value="XM_007876115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ20"/>
    <dbReference type="STRING" id="1069680.M7NQ20"/>
    <dbReference type="GeneID" id="19896001"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02308"/>
    <dbReference type="eggNOG" id="KOG3351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035272_0_1_1"/>
    <dbReference type="OMA" id="WIRQYLA"/>
    <dbReference type="OrthoDB" id="330671at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000089">
        <property type="entry name" value="Bifunctional coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001985">
        <property type="entry name" value="PRK00777.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="1">
        <location>
            <begin position="168"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="327" mass="38270" checksum="10A1CA37368CAB97" modified="2013-05-29" version="1">MTTEKTSVFMIQINENLDISKYLGFIDRSISMIKSDELVIFIIEKENKVFQAKNKTRFFNLIHELLNTIYIISENSKKRYNKADLEVNIVFNEWCGYELFSEEKNWDKIYIIKEDKCLIEAISFEMKSYVLILSDEDINSFIIKKKKFERYVKTQIEEESLSYKYVAVGGTFDHLHAGHKILLTMSAWISEENVACGVSDKELLKNKKYAEWIEPIEIRMESVRKFFYLINRTLSLSVSPIFDIYGVTIIDDRIGAIVVSQETISGGKLINEERKRRNMKELDIFCICIISDEVDSELMSIKISSTNIREKIAKKQFKNELVSEILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ46</accession>
    <name>M7NQ46_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sister chromatid cohesion protein DCC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874575.1">
        <property type="nucleotide sequence ID" value="XM_007876384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ46"/>
    <dbReference type="STRING" id="1069680.M7NQ46"/>
    <dbReference type="GeneID" id="19896254"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02562"/>
    <dbReference type="eggNOG" id="KOG0798">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034504_0_0_1"/>
    <dbReference type="OMA" id="EDKISYW"/>
    <dbReference type="OrthoDB" id="276989at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034088">
        <property type="term" value="P:maintenance of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019128">
        <property type="entry name" value="Dcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395:SF6">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09724">
        <property type="entry name" value="Dcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="41192" checksum="63881D3B4DCF1C8D" modified="2013-05-29" version="1">MSEENIELRYLKEEDEDISDKIMLMEIPEDIYEFLMAKKTGYLTLKSGYDRNNTVLCTSSKTYLLRNVTQTNSLLLFQKENDGFSLLKDAKSYLEIVSTPVRINLNHLAYVYDGYNLDVPDSTQLYTHFQVKRRIPASDEEIENAFVHSMCLFINGYLRQLSFDYAFHILQLILAYVQEEDIPLDALKFDSLMLNIGSDEREDVVELVLRRFSKSKTEPYAIDGRSIAQWIGIHLLSRHKSAPISSEKFIEKWKSTIPEPFAVHVELSLLEGQYLVIEPSTIQYFPEDTLPMDPAMRFRELFLIRPKWNLSDILPYIRGLATDETKVDALLRKFTRKQTLSQQTIVTTRNTWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ67</accession>
    <name>M7NQ67_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CBF1-interacting co-repressor CIR N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874356.1">
        <property type="nucleotide sequence ID" value="XM_007876165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ67"/>
    <dbReference type="STRING" id="1069680.M7NQ67"/>
    <dbReference type="GeneID" id="19896045"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02352"/>
    <dbReference type="eggNOG" id="ENOG502RR25">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047019_1_0_1"/>
    <dbReference type="OMA" id="LRESEMI"/>
    <dbReference type="OrthoDB" id="2159131at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039875">
        <property type="entry name" value="LENG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER LRC MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093:SF0">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="316" mass="37992" checksum="A0EE92BACDE0D14C" modified="2013-05-29" version="1">MPLNILHHKSWNVYNKSNIEKVRRDEALARKKEEEREMRMREADGKRRLRILRERSGLRESEMIEDRTEHLKGNSLYYSRAHVQSMKDSDVHLLKNEKKRKKNDDMAMLDKVLKRRCEPSQNKHINFWEDFESGKIHTDYSNPEYEKEKADADKKWNDIITMQLSNSSKEMSPWYSHLSLQSSAQRKKDQQSIERDIRIQNSIKDFNDPLTAMQSYLKQKKKIKNLDLNKKACDSLDKYNHFRKTSYEEYTRLAISDKVHKDINKDKVLEGTHLSREFQERKLQSMSDFSNQYITDYKIIGKYSSQYNPEYVNRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ72</accession>
    <name>M7NQ72_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_02357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874361.1">
        <property type="nucleotide sequence ID" value="XM_007876170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ72"/>
    <dbReference type="GeneID" id="19896050"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02357"/>
    <dbReference type="HOGENOM" id="CLU_379027_0_0_1"/>
    <dbReference type="OrthoDB" id="46189at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR09412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="731" mass="86562" checksum="37AEA1AD8BACBB2B" modified="2013-05-29" version="1">MDPELPDYNDIFSNTSITKYKELEEKFGNYINKKNQEIFLLIKNNYFNIMSIADSIIKIEEDLKTINEQFIKIKGSFGTEKLFKSSIGLNIKFKIPIYDDKLIYVYTTKLLLCLPQLIRKLASNSEYLLAATLLYKINALNDELKMKKKYNLLNSIPIMESKEFLAKMIKKKICNIIPEKNTYIILSDLFSLNIILGRTSLDIEKMFWEIRLKDISDISYKVNMDPNNFYFLLKKILYTAIIGQCIFPKEFKNYIKTRLEIDSLLVSKYYHIYNESMHILQHYKLEESSFESDKLTQDNSNNIYIEWENEILKIVQHNGSYYLNEIKTMKSLVEQWNNILLFFEQTIISFNEKNTKLNTFISKLWQSTEIIFNKRISSILKFSINIVLELEEHVNNELKNIKIQNESFKSSLFKNNSEIWNGDIKLTINSRIDKPTIFIENFKNKLNKIQEKLEKDSSIISKRQKPINIILENLKSDTYKENNVSNFHLKLIKCIYNKLSKNIGKTISVFLRLNSDNNISNTDINIICYFIRIIKLVKFSYPLGIDLNFFCNYHLKKLYKTLSLYIFLHENIKRKLKTEINKLISAKKLNILWENNQISLPNHPSSQLITIIQDLGWYMTNIGIDIFDYDAMLIIHYCFIDIIYSILKNAFNPKSLNENEDYKENEESKDENNYLYCNVENFQLIHITITGQLQLYFDMKYLLALFGNVPYKNKLEKIDYIINVTILMSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ82</accession>
    <name>M7NQ82_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_02365</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874370.1">
        <property type="nucleotide sequence ID" value="XM_007876179.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ82"/>
    <dbReference type="STRING" id="1069680.M7NQ82"/>
    <dbReference type="GeneID" id="19896058"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02365"/>
    <dbReference type="eggNOG" id="KOG3873">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034001_5_0_1"/>
    <dbReference type="OMA" id="IEESSMF"/>
    <dbReference type="OrthoDB" id="387657at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052714">
        <property type="term" value="F:mannosyl-inositol phosphorylceramide phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072711">
        <property type="term" value="P:cellular response to hydroxyurea"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF24">
        <property type="entry name" value="PHOSPHODIESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="14">
        <location>
            <begin position="8"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR09422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="404" mass="47053" checksum="A1DFAE304AA468F5" modified="2013-05-29" version="1">MNKKIRVLSLNCWGLKYISNYRKERLDLISKRIASEDYDIVGLQEVWVYSDYENMRNNTKHKLPYGKFYFSGIFGSGLVILSKFPIESTSIYKYSLNGRPSAFYHGDWYVGKGVAMATLLMPNGKKIEFFNTHLHASYGGENDEYLCHRISQAWEISKLISSAFTAGKMIIIVGDFNSKPDSIIFKIISFSGSISDSWNINIDQNQYNKKAPSHEKIIEKLCFTCDSPINTWRMKKWKKSPGKCEAKRLDYIFIDTSWFIVKYVKLAFTEIIPSLNCSYSDHFGIDALIEFMNGPNNSNPNKLKIEDLEIIQQEFNNHINQIKKYSYLKAIYFFISIIITIGLHISVFWPHNIYITFLLFLINSTIFLTCIFSLLEFIFICWELRTLSEFQEEISLVKHLILFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQC1</accession>
    <name>M7NQC1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_01060</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Also a component of the nuclear pore complex.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Cytoplasmic dynein consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
            <location evidence="1 11">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the dynein light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872972.1">
        <property type="nucleotide sequence ID" value="XM_007874781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQC1"/>
    <dbReference type="STRING" id="1069680.M7NQC1"/>
    <dbReference type="GeneID" id="19894758"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01060"/>
    <dbReference type="eggNOG" id="KOG3430">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070944_4_0_1"/>
    <dbReference type="OMA" id="THEKGHF"/>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035974">
        <property type="term" value="C:meiotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043935">
        <property type="term" value="P:sexual sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000001">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019763">
        <property type="entry name" value="Dynein_light_1/2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01239">
        <property type="entry name" value="DYNEIN_LIGHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6 11" id="KW-0243">Dynein</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR10913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="106" mass="12098" checksum="153251B3339CE86F" modified="2013-05-29" version="1">MADINNNSTKDLTECISISKNKAIIKSVDMNEDMKIDAIDCAISAIKKYNVEKDIAAYIKNEFDKKFGTTWHCIVGRNFGSYVTHETKHFIYFYLGQIAFLLFKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQE1</accession>
    <name>M7NQE1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prefoldin, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874055.1">
        <property type="nucleotide sequence ID" value="XM_007875864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQE1"/>
    <dbReference type="STRING" id="1069680.M7NQE1"/>
    <dbReference type="GeneID" id="19895769"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02075"/>
    <dbReference type="eggNOG" id="KOG3048">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091867_0_2_1"/>
    <dbReference type="OMA" id="QAKFKAC"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990113">
        <property type="term" value="P:RNA polymerase I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990114">
        <property type="term" value="P:RNA polymerase II core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990115">
        <property type="term" value="P:RNA polymerase III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23157">
        <property type="entry name" value="Prefoldin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000004">
        <property type="entry name" value="Probable prefoldin subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674:SF2">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="149" mass="17331" checksum="6BFF34322012D094" modified="2013-05-29" version="1">MEQKVDLKSLTIPQLDEIRKQIELELNYFTNSFSKLKQAQFKFKECKKLVNTLLKKENNNKEILIPLTTSLYVSGFLVSDPEKVMVDIGTGYYVEKTIDGAIKFYDERIKYLETNFRDLETHLNAKSDSLKAVTEIMQEKIKNLQTSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQH6</accession>
    <name>M7NQH6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_02108</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874090.1">
        <property type="nucleotide sequence ID" value="XM_007875899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQH6"/>
    <dbReference type="STRING" id="1069680.M7NQH6"/>
    <dbReference type="GeneID" id="19895802"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02108"/>
    <dbReference type="eggNOG" id="KOG0152">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005825_1_1_1"/>
    <dbReference type="OMA" id="NEPIYKH"/>
    <dbReference type="OrthoDB" id="187617at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000013">
        <property type="entry name" value="pre-mRNA-processing protein 40A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039726">
        <property type="entry name" value="Prp40-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864">
        <property type="entry name" value="PRE-MRNA-PROCESSING PROTEIN PRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864:SF0">
        <property type="entry name" value="PRP40 PRE-MRNA PROCESSING FACTOR 40 HOMOLOG A (YEAST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25432">
        <property type="entry name" value="FF_PRPF40A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
        <property type="entry name" value="FF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="8">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="9">
        <location>
            <begin position="215"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="9">
        <location>
            <begin position="284"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="9">
        <location>
            <begin position="361"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="566"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="566"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="609"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="627"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR09522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="655" mass="78328" checksum="7D4283BA2E449C1D" modified="2013-05-29" version="1">MSAPPWQPKPIKASDSTGSKWEAYKAPDGRIYWSDGTTSVWEKPDELKTEEEIAIGQLNWREYTAPGGRKYWYNKKSGESVWDMPEECKKVIESLNAKKEMKLDEEKKKGDEKQLTLREEMLVAGPDGKAQSIALGTTWTEENFQCGTFEEAEMVFIKMLRRNGVTSDWTWEQTMRAVIKQPQYRAIKDPIQRKLTFEKYISEMRKQESEKEQDRLAKLKTDFNRMLRMHPEIKYYTRWKVAREILDGETAFRATENEAEKKHLFDEYVAELKRIENENEQKAKREAMDAFLVLLESLKLKPYSRWSNAQAKFLEHPEFKTNPKFKILSNLDILVVYESHIKELEREFINKRQENKAKKQRAERKNREAFIKLLQNLCHDKKIGPGTKWMTIYPMIKNDIRYKNMLGQSGSTPLDLFWDIVEDAERDMRHKKNLALGIMEEQKIDFDEKISLSQFSEIISRDKRGAELSDSTLSFVYNMLRERVFRKLEDEKRNDERRRKRRISALRYVIKHLRPPIQLDDTWSNVKKRIEHTEEFLAIDSEEDRELAFKKQLRRLKEKDVSLKSYHKSNRSSKHFRYSSKNRDTDSREFNDNLYYTKDYHGYRNNGYRNHDSENENDSRYRKRIKSDKDYYSNEYNYDKDDKNTIESSEEGEIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQJ1</accession>
    <name>M7NQJ1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR10993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872491.1">
        <property type="nucleotide sequence ID" value="XM_007874300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQJ1"/>
    <dbReference type="STRING" id="1069680.M7NQJ1"/>
    <dbReference type="GeneID" id="19894293"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00595"/>
    <dbReference type="eggNOG" id="ENOG502T9YT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_649112_0_0_1"/>
    <dbReference type="OrthoDB" id="2555519at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38701">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38701:SF1">
        <property type="entry name" value="UP-REGULATED DURING SEPTATION PROTEIN 1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="423" mass="48868" checksum="F4913E6F7CA2B254" modified="2013-05-29" version="1">MNLLKLKNIDKDIKQIEAEDKSINSKVKKSKKVENFYTQVSNNLPLSTTSQSPRKLFQPFFQNEQDIYHSNESNEQEAFSVCKEIHSNLNIKQYVHSDQYPVKENISSEFKRQTYHSRKESKFFYANEFKQQKSLSEICFTKDSKTSPQLSQHKNISPPEKQQLPKFFHVNENFILSDHYLLSQDSNLPVSWKPVQPISKDNYDESLIIPSRNKTPLGSPSRREVKSTNIKNLSNIQYINDTFSMNNEIEKSPQSISKTSKIPLRGALIEESEHTKFARTNRKILDLEISNTSLLALNNTLEKQTRRQMSEIKALRKKIVPDNISITSSTTNSTSNSEENDSSQLFQNSNSSIIDFQKIVNDSLFFTKSLKKALKLTKHLINEGRHALENQKGIDIPIYLKVMKRSTNSEVLNYENAEIFENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQQ9</accession>
    <name>M7NQQ9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Non-structural maintenance of chromosomes element 1 homolog</fullName>
            <ecNumber evidence="4 15">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PNEG_02181</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the Smc5-Smc6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the NSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4 15"/>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874164.1">
        <property type="nucleotide sequence ID" value="XM_007875973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQQ9"/>
    <dbReference type="STRING" id="1069680.M7NQQ9"/>
    <dbReference type="GeneID" id="19895874"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02181"/>
    <dbReference type="eggNOG" id="KOG4718">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045153_0_0_1"/>
    <dbReference type="OMA" id="ACINHSC"/>
    <dbReference type="OrthoDB" id="185455at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16493">
        <property type="entry name" value="RING-CH-C4HC3_NSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011513">
        <property type="entry name" value="Nse1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014857">
        <property type="entry name" value="Nse1_RING_C4HC3-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973">
        <property type="entry name" value="NON-SMC ELEMENT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07574">
        <property type="entry name" value="SMC_Nse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08746">
        <property type="entry name" value="zf-RING-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Non-structural maintenance of chromosomes element 1 RING C4HC3-type" evidence="16">
        <location>
            <begin position="216"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMR09597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="279" mass="31766" checksum="6E41B0D6E023282F" modified="2013-05-29" version="1">MDINNETQFTDVHRVLLQHFIAKRSIFQEQALNSLLIAISIYENISIDSVVINISTLELYIFDINNAITCLDLEIRKTIDQSTGIVIWILINTSSDVFSQLSTSYTPSEIAFFKQLLDYILVKSNTHQLEVFSITSTQALRESSLKGVGLSKVSAEASLAAFVEEGWLSKTMHGTRVYFTLSPRSLLELYPIIKTYIDEPENDFDQDFRVPLLKRCKACHNVVTQGFRCSNMNCPVRFHEYCSKAYMAKQKDKSCPECGIIWMEENFVGDKAAERNNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NR28</accession>
    <name>M7NR28_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA repair and recombination protein RAD52</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02152</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Active in the repair of DNA damage and in mating-type switching. Probably involved in the repair of DNA double-strands breaks. Has a role in promoting S phase completion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874133.1">
        <property type="nucleotide sequence ID" value="XM_007875942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NR28"/>
    <dbReference type="STRING" id="1069680.M7NR28"/>
    <dbReference type="GeneID" id="19895845"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02152"/>
    <dbReference type="eggNOG" id="KOG4141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011431_4_0_1"/>
    <dbReference type="OrthoDB" id="206565at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045002">
        <property type="term" value="P:double-strand break repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.80:FF:000001">
        <property type="entry name" value="DNA repair protein RAD52 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="entry name" value="DNA repair protein Rad52/59/22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004585">
        <property type="entry name" value="DNA_recomb/repair_Rad52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041247">
        <property type="entry name" value="Rad52_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007232">
        <property type="entry name" value="Rad52_Rad59_Rad22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00607">
        <property type="entry name" value="rad52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132">
        <property type="entry name" value="DNA REPAIR AND RECOMBINATION PROTEIN RAD52, RAD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04098">
        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="293"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="390"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="479"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="449"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00057800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="57937" checksum="E07C6D5005756689" modified="2013-05-29" version="1">MQKLEDQSFQAQVSKSLTSFKGKEHQIAQEYTEQEASVLQSLLDRQLGPEYISYRPGVNGSKVHYLEAWKVINLANEVFGFNGWSSSIQNIQVDYIDEFKESGRLNLGVSVIVRVTLKNGIYHEDIGYGCVENFRGKGAAFEKAKKEGTTDALKRALRTFGNVLGNCLYDKTYLREIGKIHVTKNKFDISELHRHPSAFNKFPNNLTKPFELKETPIVAQPEKNIPSKDTPTLAKESELYEDGDEFDDIDFQEIDKPIDLEFCHQSEYDIEDTFSNFSHSDLVDDNIHTAEEHHTTSVNLSKNGRFEQKSATNLSHNFTNTLRKKETEKESKPYYSLNEPHKIPQNSTSTEQNTEHPPNYIPMFVNTRSVLTNSKGVVDVSSGVAFNPHIDSPSLRKTPGLDHTKSTPIRRQNASVNTTPSITNRIKQPPTSRLVGAPPTNTRHYHQDPFQSTSTKRLANNDTSRCDSSFVLNEMSDPVLNQQEPFSKENDKNNIYNSDTTNSTASKRYKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRB6</accession>
    <name>M7NRB6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873827.1">
        <property type="nucleotide sequence ID" value="XM_007875636.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRB6"/>
    <dbReference type="STRING" id="1069680.M7NRB6"/>
    <dbReference type="GeneID" id="19895550"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01856"/>
    <dbReference type="eggNOG" id="ENOG502QRU3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_283435_0_0_1"/>
    <dbReference type="OMA" id="LWSHAFY"/>
    <dbReference type="OrthoDB" id="2017974at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09880">
        <property type="entry name" value="PIN_Smg5-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF0">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN EST1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="1">
        <location>
            <begin position="934"/>
            <end position="1076"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1099" mass="128426" checksum="A82F48E99D8D1B9E" modified="2013-05-29" version="1">MSLPCISDKPILSQYSATKINNKTKALLGNNLEEPQILSKHTEEFICTHKKESEEILYKNFKSRTSLDYEEILFKPRHERYRLHLLGDLKNYTRSPNLSKKYLNIHNNTSDTDYDPSFNIPIKKLEAKLGKHFSIERTLFKKPGSAKNPKTHNSYERFFAATFQSSNQSKLFQPGLDPIPLIRKENNRLFSKNYIEKRQLKSKEFKKINNSNKKLFSSKTFINLESQKNKQVEETFFLEKQKKIINGNDSYSDYNLIIREKNPFMVTREMLLKEIKSSYKGLIHLESHVKLQDNICNQFDKKFSFSDKDHEKFRKLSELHEALLFLYINFLSLTQHPSASLSIMKIPIKYTIPARLWRNSIYTYLEILRSQLPYTIEHLISYILFSYSQITVLLETVSTFENEWIECLGDLARYRMAIEEVDMESRNHWNNVAKYWYVKGLKNLPTLGRLYHHLAILSKDNILEKLFYYSKALIVSKSFSYARGSILSLFDPIFIHKESLCFSNASKNSDLINNYVKLHGLLFTRLQLDDFEVILNDFLSLLSKENIWNKEGVLMAITNVVALFQYGNKHGKLKYLIRESKINNKKKRKETYNCFFDKNYTKLNQEYLERLTTVENKTNTLSYNINESDLPAINHSLFKAAHIASTLYYPINLINSSDLSGCRHSIKDQETSSIDHIVFLKACQLHYFIMSLSISITSSNSLAYNFICMIFLYYCSNYSSVLSSMERFIPWFKIAEYLSNIIKKIKNNSILGTSDLPVRQSKSPLPEDWALRGINWSKKIWPKAYFENMTEDDFDFTVEQPDDEIIEIRIKRIIWLGFKIASLSNILLYNTQTQRFTISEDYINKIKFSNEYFEKAILSLSHTHVFKSENENYKNDIKFNDDLEVQGESEEIKNLRERRRALKSILSKNDSKKLGCNHKKDIQHFFRQIKSGYTTLVFDTNFLISYLKLFHKVLSMNSWDIVIPLAVIFELYGLNNKPPPIGIAAHNAIILIISALKSQKAKIVTVKGNILHALNYISEQSEDNFEGEKRYRNIDDRIIQVALFQNENHVKSQKGLFASEEFEKVVLVTSDLNMRIIAKAKGLAAISAIAFRKVIKQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRL0</accession>
    <name>M7NRL0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PNEG_01931</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 25">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873907.1">
        <property type="nucleotide sequence ID" value="XM_007875716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRL0"/>
    <dbReference type="STRING" id="1069680.M7NRL0"/>
    <dbReference type="GeneID" id="19895625"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01931"/>
    <dbReference type="eggNOG" id="KOG0215">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_5_1_1"/>
    <dbReference type="OMA" id="LAYCSWC"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000020">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15 23" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="19">
        <location>
            <begin position="64"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="212"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="472"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="572"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="22">
        <location>
            <begin position="654"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="16">
        <location>
            <begin position="701"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="1076"/>
            <end position="1161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EMR09746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1165" mass="131919" checksum="B26422C9C2AC37CC" modified="2013-05-29" version="1">MTWKKINDLNKNHKDNKTTQKTLKIGQAFDILLKLEYKGKSLTDPVHTLKDKWNLLPAFLKVKGLIKQHTDSFNYFVDVDLKKIVKANEKVTSDVEPWFYLKYTNIQVGFPTRQDQDAIDNSIAPHECRLRDLTYAAPIIVDIEYTRGKQVVRRKGVQIGRLPIMLRSNKCILFNKTEAQITRMNECPLDPGGYFIVKGTEKVILVQEQLSKNRIIVEAEPKKGLVQASVISSTHERKSKTYVLTRNTKIYLKHNSIAEDVPIVLIFKAMGLQSDREILELVAGLDPVYQDIFSINIEECAKLKIYTQQHALEYLGTRVKISRRNSGIIQRRPPSEEALEVLAAIVLAHIPIKNLNFRPKIIYFAIMTRRVLMAMKNPKMVDDRDYVGNKRLELAGQLLSLLFEDLFKTFNRNLKLNIDKVLKKPNRTQEFDAYNQISIHGDHITFGMIRAISTGNWSLKRFKMERSGVTHVLSRLSYISVLGMMTRISSQFEKTRKISGPRALQPSQFGMLCPSDTPEGEACGLIKNLALMTHITTDNDEEPIEKLAFILGTEDISLITGHELYAPGTYVIYLNGTILGITRFPANFVSNFRKLRRKGRISEFVSIYINNHYCSVHIASDGGRICRPLIIVENGKSKVTPRHLKSLKAGKMTFDDFLKRGLVEYLDVNEENDCYISIYENKLSESTTHLEIEPFTILGAVAGLIPYPHHNQSPRNTYQCAMGKQAIGAIAWNQLLRIDSLLYLMVYPQQPLVKTKTIELIGYDKLPAGQNAIIAVMSFSGYDIEDALILNKASIDRGFGRCQVMRKYATTIKRYANGAYDRLEHPDRSEDGQLVWKYETLEEDGLSGVGEKIESGQIYINKQIPTNANDNTIATGIQQHELSWKAAPMVYKSLEPGYIDKMMLTTTDSDQTLIKCLIRQTRRPELGDKFSSRHGQKGVCGLIVQQEDMPFDHNGITPDIIMNPHGFPSRMTVGKMIELLAGKAAVLNGTLQYGTAFGGSKIDYISQILVENGYSYSGKDQLTSGITGEALQAYIFFGPIYYQKLKHMVLDKMHARARGPRAILTRQPTEGRSRDGGLRLGEMERDCLIAYGASQLLLERLMLSSDAFEVHICETCGLIGYKGWCNRCKSTKSVTKLTIPYAAKLLFQELISMNIIPKLILKDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NS44</accession>
    <name>M7NS44_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit epsilon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_00022</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COPE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871873.1">
        <property type="nucleotide sequence ID" value="XM_007873682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NS44"/>
    <dbReference type="STRING" id="1069680.M7NS44"/>
    <dbReference type="GeneID" id="19893720"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00022"/>
    <dbReference type="eggNOG" id="KOG3081">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049363_1_0_1"/>
    <dbReference type="OMA" id="AVERDCI"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006822">
        <property type="entry name" value="Coatomer_esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805:SF0">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04733">
        <property type="entry name" value="Coatomer_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR11578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="28042" checksum="F2A6EDB3103D1391" modified="2013-05-29" version="1">MMDIEIDFFQARNLFYQGCFNLLLEKDLGENQAARILKGRAQRMLGKGNEILWELKNETTPEFLALRGWVLYEEGDKEQGISEIRSCISTSSKNATVQVLGGHVLYREEQYEEALELLKGHSENVEAVALIIQIFLKENQLKEAQKELEIARTWASDDIIIQLSEAWIDLYKGGQAALNSFYIYEELAQTTPNSLTLTGQAVAELQLGRLEDAEETLAQVLTLTPHDGDALANAIVTATLLGKDTSVYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSD8</accession>
    <name>M7NSD8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rho1 guanine nucleotide exchange factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873758.1">
        <property type="nucleotide sequence ID" value="XM_007875567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSD8"/>
    <dbReference type="STRING" id="1069680.M7NSD8"/>
    <dbReference type="GeneID" id="19895484"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01790"/>
    <dbReference type="eggNOG" id="KOG4305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001251_6_1_1"/>
    <dbReference type="OMA" id="FAHVNDI"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04435">
        <property type="entry name" value="DEP_fRom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF2">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="542"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="764"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="5">
        <location>
            <begin position="916"/>
            <end position="1214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1246" mass="143708" checksum="6BBB80741013F12F" modified="2013-05-29" version="1">MNDQYLKHSELSDLDHDLSYTNMAISKNDELLIDNYAKEQYMPLEPHFKSQDISKYYERRSYSEQFHMHHSDTNINRHYYTDAEVVSQSQYKVRSNQSSSNIHTLNSKTDTDFDRAQSFTPSLKYYPNSLSLYFQKSFSPEQSFEYADHVSLYHDFNQISEKGAGNTEVCLETCSNKNTNISEEKISDDKVIKRPENNTYLLQPHQPKSSIVMKNVENKDSFRNQAFKSDSWRENIRGVYYNIYPGQRLENVSTNNRMWSLYNALTPTNELSGSDRPKHSSSNVSSITTKTSNSYPAVYPALLSCVAEAFRQRVILGDKLKDGLTYKDAFTGSEAVDVISKIIRTMDRNLALLLGRSLDAQKFIHDVTYDHRLRDSPNEVYQFRECLSSLSNTDINAQLKADKNDLNKSLTSKVLSQGDLGASYDNHLLNTHSALSCIDFTVSKNCRKTFQNDVDDLPNGVFTLLTECYSPTCVRDQLCYSISCPWRFEQQARLNMKPHSALKRAESRYSLSGLDDTEKEQKLWIQSVPREIADSLNEREKKRQEIICEVIYTERDFVKDLEYLRDFWIKPLRCGNLIPEYRKEKFILAVFSNILDIHAVNSRLAEALTKRQQQHNVIYRIGDIFLEFVPRFDPFIRYGANQLHGKYEFEKEKRENPVFSKFVEETERLRESRKLELNGYLTKPTTRLARYPLLLEAVAKSTPDDNSDKADLMKAVKLVKDFLTKVNIESGRAENRFNLMQLSKQLIFKPGEGLDLKLSDENRRLIFKGILKKRSVSSASMDSGSDIQVFLFDHVLLMVKMTKREQYKVHRKPIPLELLIISQSEEPSERSFVAKRTPLLLNTTLKSTPHKNDNSKGYAITFIHLGRRGYMITLYATTSISRKKWAEHIESQQRSLKERSCIFKRQIICEKYFLRGNKVTCVAPFDGGRKLIYGTENGVYVSDRKPHSSVKATPVRVLAINGVTQVDVLEEYSILLVLADKTLYSYPLESLDLNDTTLANKRPRKIVGHANFFRSGLCLGKLLVCVVKSSVLSSTIKILEPIDNVCRGKKQAPFRFLLQGGQDVLRVFKEFYIPTESTSVHFLKHKLCVGSPKGFEVVNLENLETQSLLDPADTSLDFVTRKENIKPIAIYRLNLKFLLCYDEMAFFVDKNGWATKHDWMIIWEGLPTSFALFYPYLLAFEDSFIEIRHVETTALVQVILGHNIRKLHDNYRECLYAYTDDDGVDKIASLDCWESLKIQSRISSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSD9</accession>
    <name>M7NSD9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_01456</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="10"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873396.1">
        <property type="nucleotide sequence ID" value="XM_007875205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSD9"/>
    <dbReference type="STRING" id="1069680.M7NSD9"/>
    <dbReference type="GeneID" id="19895153"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01456"/>
    <dbReference type="eggNOG" id="KOG1885">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008255_6_0_1"/>
    <dbReference type="OMA" id="DFRNEGM"/>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000050">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000238">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001756">
        <property type="entry name" value="PRK00484.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF9">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="250"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR10182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="586" mass="68183" checksum="4FFF8A8B4AD0167A" modified="2013-05-29" version="1">MEESSPSNQLKQLKNLCLDERSGEYVSKTELKRRLKLQEKKEKREARTLATVSSKPSQKHVSEIHEDLTPNKYYELRSRHINMLRTCKNLDAYPHKFHVNIQIEEFIKTYSFMKRGEVNRDIIVSVAGRILNKRDSGSKLRFYDLYNDGVKIQVMAQAQDCEKDYLEMHEHIQRGDIVGIIGYPGRTSPKGKGKNEGEGGELSIFCKEMVLLSPCLRMLPMERQGLTNQETRYRQRYLDLIINKTTREKFIMRSRIIQYIRNFLDSRGFLEVETPMMNFIPGGASAKPFITHHNELDLDLYLRIAPELYLKMLVVGGLNRVYEIGRQFRNESIDLTHNPEFTSCEFYCAYADMYDLINMTEEMLSNMVFELTGDYKIKYHPNGLEGEEIIVDFSRPWNHIEIIPFLEEKLNVIFPPGDQLHTEETTKFLICLCEKHNVEYSPPITNSRLLDKLISEFLEPVCLNPTFLIGHPQIMSPLAKYHRSKVGLCERFELFVAYKEIVNAYTELNDPVEQRMRFQEQAKQKDQGDDEVQIIDENFCLALDYGLPPTGGWGMGIDRLVMFLTDSSNIKEILLFPTMKPDVTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSG1</accession>
    <name>M7NSG1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ran GTPase-activating protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_00124</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871983.1">
        <property type="nucleotide sequence ID" value="XM_007873792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSG1"/>
    <dbReference type="STRING" id="1069680.M7NSG1"/>
    <dbReference type="GeneID" id="19893822"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00124"/>
    <dbReference type="eggNOG" id="KOG1909">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028747_3_0_1"/>
    <dbReference type="OMA" id="NGSMEAW"/>
    <dbReference type="OrthoDB" id="184583at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006404">
        <property type="term" value="P:RNA import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR11688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="44515" checksum="10A72E20002CB7F6" modified="2013-05-29" version="1" fragment="single">MAANNHIFSLSGRGLKLESKEETLSAIEQLVLEENIREIYLNGNTMSVEACRILGEVIRTKKDLEVVDFSDIFTGRSAKEIPFALEYLLSGLVSSGKCNTVYLSDNAFGPTASKPLIAFLSRHRPLKHLYLTNNGLGPSAGACVARALEELAKIQSVEPSIYLETLVCGRNRLENASMKAWSACFRAQKNLTHVRMSQNGIRPEGIRILLETGLSACSLLQTLDLQDNTFTVLGAKTLARMLPKWPHLVELGVSDCLLSRAGGKLLAQALFDSNFIRLKILRLQYNGIDEEGVEILANAIERTLPNLELLELNGNVFSEEDESVEKIRNIFEKRGKGVLDDLDDMEEPSESDNIGESSELENSDDLNENLDHIEEKEIEFPIKKEARTNISALLERTHLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSJ1</accession>
    <name>M7NSJ1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01841</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873813.1">
        <property type="nucleotide sequence ID" value="XM_007875622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSJ1"/>
    <dbReference type="STRING" id="1069680.M7NSJ1"/>
    <dbReference type="GeneID" id="19895535"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01841"/>
    <dbReference type="eggNOG" id="KOG2294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_474164_0_0_1"/>
    <dbReference type="OMA" id="WMINSEY"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060963">
        <property type="term" value="P:positive regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22701">
        <property type="entry name" value="FHA_FKH1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000030">
        <property type="entry name" value="Forkhead box protein K2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF1">
        <property type="entry name" value="FORK HEAD PROTEIN HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FHA" evidence="7">
        <location>
            <begin position="54"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Fork-head" evidence="8">
        <location>
            <begin position="237"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="237"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="575" mass="65443" checksum="87C21D1DD717CB9B" modified="2013-05-29" version="1">MTINTFEMQSKNSLDIMIKNEDTGIIEPQPSRNVQAYAKLEFDAFSFYIQTLQVIIGRKVNKLDQVDVHIGSTKAISRQHAKLFYDFTSQRFEIFVMGKNGAFINEEFVECGQTIPLYDKTKIQIGKVLFTFLLPKSTEKENTENRDIRENQRIEKSEFSQDISLLSNSVSTERSLVTYPNINLELSLIKTDEPDILPISSRILNNETLSAVNSTFHDESLLSHAESFNVSMKEHSKPNLSYASLIAQAILSSPSKKMTLSDIYEWITDTYKYYKYAQNGWQNSIRHSLSLNKAFKKVSRRDDEPGKGSFWMINSEYQCQFEDGIYKRNRKSIISSYQHLTTPSIMADGASRSTADSIPIAIMQDGQLALNPEYFNTVNDSNDSNKIQIVQAIVFLQRYIITQLGPHAKIPQNAAAIANALIVALDQQLQKHQNHKNFISNIFKNLTFLLPNTNEKMHTSLNEFSTENKQYITNTSTSLEFITQIPKGSEVSKEILDSSVNQSYSFNDKLVSKELYPIQVPPPPPYYSKPLTSSTENNLSLNSIEKKELQFLSSKSYSINSESTHKQGLKRPHEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSJ5</accession>
    <name>M7NSJ5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PNEG_01504</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873444.1">
        <property type="nucleotide sequence ID" value="XM_007875253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSJ5"/>
    <dbReference type="STRING" id="1069680.M7NSJ5"/>
    <dbReference type="GeneID" id="19895200"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01504"/>
    <dbReference type="eggNOG" id="KOG1147">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001882_1_2_1"/>
    <dbReference type="OMA" id="FIHIPDG"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000070">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1160.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.800.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000004">
        <property type="entry name" value="Glutamyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="entry name" value="Glutamyl-trna Synthetase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.800.10">
        <property type="entry name" value="Glutamyl-tRNA Synthetase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02076">
        <property type="entry name" value="Glu_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF5">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="14">
        <location>
            <begin position="211"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="15">
        <location>
            <begin position="518"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="16">
        <location>
            <begin position="622"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMR10232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="726" mass="84196" checksum="0C2085B49DEDE603" modified="2013-05-29" version="1">MLKEKSPILHLSIQKTPVPYGIFLVTLWINQESQSIDINYVNDLYINEDNKEEGLSFQKCMDDCYIYGTIPILKELLRYLKEPLKNEESIVKWAEYSMEKINILTFNDMDSVFLYLNDFLLEKKALIDDRITLADWIVWGALRGNVYAQGIIKKNIYPCLNRWYRMVESDTFVSRAVQLLLKEITSRKSRSKGKNPTANYDIGLQDAIEGKVVTRFPPEPSGYMHIGHAKAAILNEYFAKKYKGKLIVRFDDTNPSKEKGEFQEAILKDLDSLGIKADQVSFSSDYFDKTYDFCVQMIKDGNAYADDTDKETMRAERMQGIESKRRQRSIEENLEIFSQMRKATEIGLLNCIRAKISVNSLNKALRDPVIYRCNTTPHHKTGTIWKVYPTYDFCCPIVDSIEGVTHALRTNEYKDRNAQYQWMIKTLNLRKVHIWEFSRINFVRTLLSKRKLQQFVDDKRVSGWDDPRMPTILGIRRRGMTIDALKQFIISQGPSKNVLNLDWSSIWAINKKIIDPIAPRYTAINSDNLVKVFIINGPSTVHIEERPKHKKNPQVGMKKVAFYKNIILDQEDALTFKDNEEITLMDWGNAIIKKIIKNDFGIIDSIEMELHLEGDFKATEKKITWLADLPNLIDVQSVDFDYLILKDKLEEGDRLEDFLTPCTEFHSKIKVDENFLNLSKSDIIQLERKGYFICDQPCNNEGKGLVLFKVPDGKVINKYGVKKIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NST3</accession>
    <name>M7NST3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_01583</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. DCP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873537.1">
        <property type="nucleotide sequence ID" value="XM_007875346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NST3"/>
    <dbReference type="STRING" id="1069680.M7NST3"/>
    <dbReference type="GeneID" id="19895278"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01583"/>
    <dbReference type="eggNOG" id="KOG2937">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_512023_0_0_1"/>
    <dbReference type="OrthoDB" id="18996at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140933">
        <property type="term" value="F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03672">
        <property type="entry name" value="NUDIX_Dcp2p_Nudt20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1050:FF:000003">
        <property type="entry name" value="Decapping enzyme Dcp2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000003">
        <property type="entry name" value="M7GpppN-mRNA hydrolase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1050">
        <property type="entry name" value="Dcp2, box A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007722">
        <property type="entry name" value="DCP2_BoxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036189">
        <property type="entry name" value="DCP2_BoxA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044099">
        <property type="entry name" value="Dcp2_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114:SF17">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05026">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01125">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140586">
        <property type="entry name" value="Dcp2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="9">
        <location>
            <begin position="95"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR10327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="532" mass="61441" checksum="D5E7FFE759784287" modified="2013-05-29" version="1">MVSLRNATFEEILDDLSVRFIVNLPEEELGSIPRICFQIEQAHWYYEDFIRELNPQLPSMHLRTFCLTLFAHCPLLWKWNKEYEKAYDNFLKYKIRVPVRGAILLNETCEECVLVKGWKNSSGWGFPKGKINKDELDTDCAIREVFEETGFDISKLIQPNDYIEITLCEQNIRLYIIAGVPSDTNFITHTRKEISKIRWHKLSDLPAYSKSRKEDNYGNKEASKSKYYLVAPFLEPLLRWIRKRKKPYLNSIEIMKEYVDSDFETDQNICRKNSETLKTLLGISSYSPISTTSFTMSVDLTHSSKEEVSFLNKNISDNDHKTNPKYDKDTVFNISKKDSEEKNRGAKRIMELLHLNINNNANKIYEKDISYEKNNNALSFEEKLRKNRNFPPSPSEIPSNFSTNTSVFNQVSLNTSEEKNMGSNYNINNCNKEKLLLALLGKQVSDLEVNSLQKKNLNIKNDIIIKQTNTNKHSGNAYKPDGLKNIQTPLLSKISPTSSSSVTNTNGTAIEKLDAQLLCYLENVIIKARNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTG6</accession>
    <name>M7NTG6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA polymerase</fullName>
            <ecNumber evidence="20">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">PNEG_01633</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="20"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873590.1">
        <property type="nucleotide sequence ID" value="XM_007875399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTG6"/>
    <dbReference type="STRING" id="1069680.M7NTG6"/>
    <dbReference type="GeneID" id="19895327"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01633"/>
    <dbReference type="eggNOG" id="KOG0969">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000203_2_0_1"/>
    <dbReference type="OMA" id="CNNCRPR"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904161">
        <property type="term" value="P:DNA synthesis involved in UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903459">
        <property type="term" value="P:mitotic DNA replication lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006278">
        <property type="term" value="P:RNA-templated DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05777">
        <property type="entry name" value="DNA_polB_delta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05533">
        <property type="entry name" value="POLBc_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056435">
        <property type="entry name" value="DPOD/Z_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF23">
        <property type="entry name" value="DNA POLYMERASE DELTA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24055">
        <property type="entry name" value="POL3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 20" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 20" id="KW-0235">DNA replication</keyword>
    <keyword evidence="17 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14 20" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 20" id="KW-0408">Iron</keyword>
    <keyword evidence="16 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase delta/zeta catalytic subunit N-terminal" evidence="24">
        <location>
            <begin position="135"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="22">
        <location>
            <begin position="227"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="21">
        <location>
            <begin position="525"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="23">
        <location>
            <begin position="993"/>
            <end position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF24055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EMR10381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1086" mass="125172" checksum="1F72C41661A57671" modified="2013-05-29" version="1">MSKISKIKRKDIEVLQDIKNDLFMDNDIKKRRISEENSYDLEFITQKKALKYKKTLRSFKNDLECIIQELLENQQENKNENQKWERPSLPLIDPINDDIYFQQIEIDDTMSVSGPILRLYGVTEQENSVLCTVTGFFPYFYVPSPQGFYEEHINSFKIALENTVNFSSKVINNIELVMRQTIYGFHKDGKTQYIKITVNDPKHIARVRNLFERGDINFNNMFPPQYITFESNLPYALRFMIDTSITGMSWVKLPKTKYLIVDEKTSNCQLEVFIDWKDLETFQPEGNWQKIAPLRILSFDIECAGRKGVFPEPEIDPVIQIANVVTLYGEKTPFIRNVFTIDTCAQISGAQILSYADQKELLLAWSKFIQKTDPDVIIGYNIANFDIPYLIDRAKHLKVNDFPYFGRIIRQKCEINNTSFSSRAYGTRESRFTDISGRLQLDMLQIMQRDYKLRSYTLNAVSSQFLNEQKEDVHHSIITDLQNGTSESRRRLAVYCLKDAYLPQRLMDKLMSLVNYIEIARVTGVPFSYILSRGQQIRIVSQLSRKAREKGFIIPNVKSEGIDEQYEGGTVIDPKKGYYNVPIATLDFTSLYPSIMQAHNLCYTTLISYKQIEILGFKKDRDYHVTPENYCFVKPHIRKGLLPQIFENLLAARQKAKLDLKNETEPFKKAVLDGRQLALKISANSVYGFTGATNGKLPCLPISSSVTSYGRQMIEKAKDEIELKYTLENGYTHNAQVIYGDTDSVMIDFGVKDIAESMRLGCEAADYVTSKLIKPIKLEFEKVYFPYLLISKKRYAGLYWTKPETFDKMDSKGIETIRRDNCRLVSTVIETALRKLLIDRDIDDAQNYVKKVISELLQNKIDISNLVITKTLTKSDYVSKQAHVELAERIRKRDSGLAPTLGDRVAYIIVKGAKGDQTFLRSEDPIYVLENNIPIDTKYYLDNQLSKPLLRIFEPILGEKANSLLSGDHTRTISMTSPAIGGLVKFTVKTATCIGCRIPLKNDSNAVVCNHCVGRTAELYQKQLNLVSDLEIRFAKLWTQCQRCQSSLHQDVLCTSKDCPIFYMRKKVQKDIKENIEILERFNENW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NU17</accession>
    <name>M7NU17_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00901</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872812.1">
        <property type="nucleotide sequence ID" value="XM_007874621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NU17"/>
    <dbReference type="STRING" id="1069680.M7NU17"/>
    <dbReference type="GeneID" id="19894599"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00901"/>
    <dbReference type="eggNOG" id="KOG3859">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021805_1_0_1"/>
    <dbReference type="OMA" id="IGRQFPW"/>
    <dbReference type="OrthoDB" id="5337438at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="3">
        <location>
            <begin position="61"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="375" mass="43708" checksum="F624D91BFEE9417B" modified="2013-05-29" version="1">MVFEQLSQLSLENQEERLEISPITPKLNRLGGRSATESPLSSRHPTENTPDSPRRHRRRKEPTSFNILVIGFCGSGKTSFVEYLSEQLNTLKDQQHSAMKEEEKPDYLDMGFTCYYAEAEINGERIGVTLWDSRGFGTSRDYEIVNLQMDEIILFMESKFENTFSEETKVIRSHKHIDTHIHCVLYLIDSTSSYLYNDVSLDSLDISIIQKLSRYTTVIPVISKVDTCTKRRIGDIKLAWRKEFEKSEIKILEFLGNNESHDDVSTSESTHSREKDENYDDIYNLLPFGCMTPDRAQIIPFSAEKAMKFDISREYSWGKANPLDEKHCDFSKLKEMVLGEWRNEIRDFSKEVLYENWRTDRLEKLRNLSSKDNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUB5</accession>
    <name>M7NUB5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01028</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872941.1">
        <property type="nucleotide sequence ID" value="XM_007874750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUB5"/>
    <dbReference type="STRING" id="1069680.M7NUB5"/>
    <dbReference type="GeneID" id="19894726"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01028"/>
    <dbReference type="eggNOG" id="KOG4124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_619885_0_0_1"/>
    <dbReference type="OMA" id="QPIDITY"/>
    <dbReference type="OrthoDB" id="3269380at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060963">
        <property type="term" value="P:positive regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090070">
        <property type="term" value="P:positive regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051580">
        <property type="entry name" value="ZnF-Chromatin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057:SF0">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="354" mass="39547" checksum="1D3691FE54607BC8" modified="2013-05-29" version="1">MQSPEIRRERVSTDGSHVSWKHGNLLSNSLQGQSFLGSGGNSMDTDEGLGCEEYLCPRLEISFCKDFNCCGVVLRDLHDLCRHYEEAHVRLEEGLFVSSGVRFANSAFACRTEWDGKPRLDMYESLNGDMDLDQEFAFDHLFQSLSDSDRQGQSLAPLSVSTRDFLLSSSNISTPSSSMPSTPTFDSSQEFLVLDMDDTETVVLNGSSLLAEEWVKQQMVKKQCQHGVSLSDTESRGTIDSPGSNFVVVDKPYKCPVMGCDKAYKNQNGLKYHKLHGHCTASVMLQDTTIPASFSDEIVASSPKGNPVLENKPYKCELCNKRYKNLNGLKYHKAHSHQQISMAQVQREVLMQGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUC3</accession>
    <name>M7NUC3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01038</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872951.1">
        <property type="nucleotide sequence ID" value="XM_007874760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUC3"/>
    <dbReference type="STRING" id="1069680.M7NUC3"/>
    <dbReference type="GeneID" id="19894736"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01038"/>
    <dbReference type="eggNOG" id="KOG0533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052367_2_2_1"/>
    <dbReference type="OrthoDB" id="346839at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071040">
        <property type="term" value="P:nuclear polyadenylation-dependent antisense transcript catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140746">
        <property type="term" value="P:siRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF35">
        <property type="entry name" value="RNA ANNEALING PROTEIN YRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="126"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="252" mass="28283" checksum="2D2A5D0F9AC6A624" modified="2013-05-29" version="1">MTPLDKSLDEIIASRPSGRIRRIPKRMRRIRTRLGTRKITQIVSATTAAAAIQAVMEEGSKIIVSNLVSFFRIVSLKKWYEIIKAKTLEEAGLSPSFGRRSVSLFNAFFLSYSLIFIYQPLSRASKDLFSKSIGPTRRCFLSYGPNGQSKGIATVIFQRKADASRAYELYEGRLIDGIRRMKIEIVLDPGKSMASSSLSQRIGPGISRGRRLKKPGKGTGRFKRVPRPKKTLEELDAEMIDYFGSANQEIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUE1</accession>
    <name>M7NUE1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_01063</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 22 family. PIGB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872974.1">
        <property type="nucleotide sequence ID" value="XM_007874783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUE1"/>
    <dbReference type="STRING" id="1069680.M7NUE1"/>
    <dbReference type="GeneID" id="19894760"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01063"/>
    <dbReference type="eggNOG" id="KOG1771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012353_2_0_1"/>
    <dbReference type="OMA" id="HHMVFNN"/>
    <dbReference type="OrthoDB" id="416834at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF4">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR10917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="501" mass="60530" checksum="9F6A789921561819" modified="2013-05-29" version="1">MFVFHGIYKELVLFFILLQLRFFVALTSKTFFQPDEYWQSLEPAHQFVYGYGYLTWEWREGARDFVYPFIFSIVYWLLKLTKYDSSYLIIIFPKLLQAIFTTISDFYTIKLSLKLHGERVSFWTLFIVITSPFNIFFGYRTFSNTLETVFIICALYYWPLNFKGFQKKELRFSFIFVSIACILRPTNILIWLFLLGCLFFCGNFKFIFDVFIIGFISFLFLFLLNFYYYNRWTLPFVKFLKFNLIDDLSVYYGSSPWHYYLFQGLPILLFLYLPFGLHGAYLHRKTIYFRLIIFILFCYSMIQHKEIRFIYFLSPLLYIFSAKSISYVPMFIIKKMVSLILIINVIVIWYINQVHQRGVIDVMGYIRNNLDVFGVVFLMPCHSTPWQSYVHRPDIQMRFLTCEPPTSLHQNNISIKYRDEADRFYDDPYLFLQKYFVYESLNSTLQDGFFWPSHFVFFENLLTIIDSHVNILGYKECARFFNSHFIDDWRRKGDVIVYCKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUF3</accession>
    <name>M7NUF3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872990.1">
        <property type="nucleotide sequence ID" value="XM_007874799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUF3"/>
    <dbReference type="STRING" id="1069680.M7NUF3"/>
    <dbReference type="GeneID" id="19894775"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01078"/>
    <dbReference type="eggNOG" id="KOG2699">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_733875_0_0_1"/>
    <dbReference type="OMA" id="FPDRTHI"/>
    <dbReference type="OrthoDB" id="440781at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16105">
        <property type="entry name" value="Ubl_ASPSCR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021569">
        <property type="entry name" value="TUG-UBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467:SF1">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11470">
        <property type="entry name" value="TUG-UBL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="318"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="471" mass="54333" checksum="7E51E2167DC52E31" modified="2013-05-29" version="1">MPGNIIILLDSKRYTIKTTPTQLINDLLLEGCRKAELNPQEYSLKYGSNILDLSLPVRLARLPAGAKLTLVKQKYIEQDIKVALQVVDQEKRLIMSFPADTTLWEILCYFEQTTDPPINITKRSVTAKFKNQVNEYYETPIVRIISKEFNGPEVLQKITLASQGIVNGSVVLQVKFEKTQKYFNEMMALHPQKNIKLPGKNIKMDIESNSENKEDTKQTKCQISQKPLFQIPEHDTSKEISNDELISKREILILSKPASSSLYASKVNTNEEDYELTLEMAISYQNILSSRTKRIGNSKNSNIHQELEQKNNLKKKYNIKFKLPDGMQIISSFEGNERVEALYDFMRYVIRYSDEPFYLYITPPPKHLLNVKETLASNPNFSTKTTVIFKWADNIQSYVKEHSTLKDTYLNMQKDISTIATSLKNEEEEEEEEKKQEEKKQDYKPLTISSNSPSLCTPSSKKMPKWLKLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUI5</accession>
    <name>M7NUI5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="8">ATase</shortName>
            <ecNumber evidence="3 8">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_00570</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="3 8"/>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR10967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872465.1">
        <property type="nucleotide sequence ID" value="XM_007874274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUI5"/>
    <dbReference type="STRING" id="1069680.M7NUI5"/>
    <dbReference type="GeneID" id="19894268"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00570"/>
    <dbReference type="eggNOG" id="KOG0572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022389_2_1_1"/>
    <dbReference type="OMA" id="IRHFGVK"/>
    <dbReference type="OrthoDB" id="191723at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046083">
        <property type="term" value="P:adenine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11907">
        <property type="entry name" value="AMIDOPHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082530" description="Amidophosphoribosyltransferase" evidence="11">
        <location>
            <begin position="17"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="12">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR10967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="526" mass="59858" checksum="86A41C9349A47FE7" modified="2013-05-29" version="1">MCGILALLLADPSGFACPEIFEGLNILQHRGQDAAGIVTCGSQGRFYQCKGNGMVRDIFRDYQLRELYGNMAIAHAGSFANSEAQPFYVNSPYGIVFAHNGNLTNTEELHKYLDEIAHRHINTNSDSELLLNIFASYLSRFQKSRATYDDLFKALSSLYRHCQGGYACVAMIAGYGILGFRDPNGIRPLVFGERESKYGKDYLFASESVALDQLGFTNYYDVKPGQAIFIEKNKTTEPQKHPIIKQVHEQLGYTPDIFEYVYFARPDTVMDGISVYRARLKMGRYLAKTVQKKFGEDVANKIDVVVPVPDTSRNAALELAQTLNLNYKEGFIKNRYVGRTFIMPGQQIRKKSVRRKLNIQALEFNKKNVLIVDDSIVRGTTSKEIIQMAKDAGAKKIYFASCAPPIRYPHVYGIDLASRKDLIAYQRTETEIAKEIGADEVIYQTLEDLYKSCQHNSLVSGFETSVFTGKYVTNIDKKYLDHLEKFQENNRKIHEHNISITNFHGSNINRTFEDISLYNHYDYFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUS4</accession>
    <name>M7NUS4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00655</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the GSE complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11057.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613316.1">
        <property type="nucleotide sequence ID" value="XM_019757728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUS4"/>
    <dbReference type="STRING" id="1069680.M7NUS4"/>
    <dbReference type="GeneID" id="19894353"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00655"/>
    <dbReference type="eggNOG" id="KOG3887">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047421_1_1_1"/>
    <dbReference type="OMA" id="NCRTFQE"/>
    <dbReference type="OrthoDB" id="26136at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11385">
        <property type="entry name" value="RagC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000643">
        <property type="entry name" value="Small monomeric GTPase (Gtr2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039400">
        <property type="entry name" value="RagC/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF2">
        <property type="entry name" value="GH16429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11057.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="328" mass="38024" checksum="F408BEA6F6C54DBA" modified="2016-03-16" version="2">MALNHDLCMIPMYSYRPRLLLMGLRRSGKSSTKRVVFHKMPPNETLFLESTNRINKDDINSFIDFQVWDFPGQIDFFDSTFDLDAIFGEVGALIFVDEYLEALSKLHITITKALAVNPNINIEVFIHKVDVLSDDYKIDTQRDIQQRVLDELLDSGFDNVSISFHLTSIFDYSIFEAFSRVIQKLIPQLPTLENLLNIFCSNSVIEKAYLFDISSKIYIATDSSPVDVQSYEICSDYIDVILDVFEIYGYERKYNSNNENTTDEREISSVIRLSNGMALYFHEINRYLALVCLLRTENLEKQSLLEYNVQCFSKAIEQIIHQMTYTCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUW0</accession>
    <name>M7NUW0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00691</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872589.1">
        <property type="nucleotide sequence ID" value="XM_007874398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUW0"/>
    <dbReference type="STRING" id="1069680.M7NUW0"/>
    <dbReference type="GeneID" id="19894389"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00691"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014456_0_0_1"/>
    <dbReference type="OMA" id="CRRMKEV"/>
    <dbReference type="OrthoDB" id="289314at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06867">
        <property type="entry name" value="PX_SNX41_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044106">
        <property type="entry name" value="PX_Snx41/Atg20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051079">
        <property type="entry name" value="Sorting_Nexin_Autophagy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979:SF2">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="8">
        <location>
            <begin position="64"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="465" mass="53495" checksum="97988ADF611319AA" modified="2013-05-29" version="1">MEGLEKSNPFFGESSQCGRSFLYESERISTLNKTDEDSTEINSCKMEEAMCCHIHSILNSVHEDPFISIVDTEKIGENAGRRFITYKIRIKNLEVRRRYSEFESLRKSLSRLFPTLIVPPIPEKHSIYLTIPLSSVKKDANFITQRKRMLQVFLNRCAFHPILKRSHVFHCFLNEDISWSQVLESPPISLLPQSVLMAPPLNPCSSINSTIYQCLPIPPSGAKLSNIHNRDEIHELGAAYNILSISEIGELASGIERFGLANDLNCHSNNELVKNLDFVLSEPLKEFTQFHEVARSRLKYRRQKVLQYEIVVNILNQNKNILDALEKSEMEAQKIESSLARLNNSESNLSTLNSDEPNEHEQTKQIIPTFIEKITGVLKGMIDVDSTTRKKNIEKIYEKISQLENALKITKKDSNIVGQAIIEEFERFHSFIRKDYCELMINIGKCYIEWAKKNIKIWEDAKCLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUW5</accession>
    <name>M7NUW5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Coiled-coil domain-containing protein 47</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00696</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872594.1">
        <property type="nucleotide sequence ID" value="XM_007874403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUW5"/>
    <dbReference type="STRING" id="1069680.M7NUW5"/>
    <dbReference type="GeneID" id="19894394"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00696"/>
    <dbReference type="eggNOG" id="KOG2357">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042570_1_0_1"/>
    <dbReference type="OMA" id="MHLVRDM"/>
    <dbReference type="OrthoDB" id="10039147at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012879">
        <property type="entry name" value="CCDC47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883">
        <property type="entry name" value="ADIPOCYTE-SPECIFIC PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883:SF0">
        <property type="entry name" value="PAT COMPLEX SUBUNIT CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07946">
        <property type="entry name" value="CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="275"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR11097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="39019" checksum="F0D4BB82E1DB3B91" modified="2013-05-29" version="1">MESFFYDKCCFFFLMLYVIISEYGRLKNAFLAKKWFETLFPLLTNQFVQVGIKRNDPMPLHIRDPGYFISYATGRIHIAYLYIQFKFLVRQNFLSFIRQVVVGFFSDNPMPHDRLYIDMIVEDHVFDACVFAVVNKSKMRWLREKYYNLSFTCVMELPILPETYVVMSEFCEIASILLENNESFIQCIKTPDVVLEYLIVSDLPIKCPKSPDQTYQKTVSFCVKLPSLCYSQQVACIFSECIAFVDLLAGRAHWRSNISQKLKSIREEANKKLKKRQDEEKLANALKKKSEKDKQKKERIRNLSSQEQRKYLDKERERKYKKLFKVIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NV74</accession>
    <name>M7NV74_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Swi5-dependent recombination DNA repair protein 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00784</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SFR1/MEI5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872688.1">
        <property type="nucleotide sequence ID" value="XM_007874497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NV74"/>
    <dbReference type="STRING" id="1069680.M7NV74"/>
    <dbReference type="GeneID" id="19894482"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00784"/>
    <dbReference type="eggNOG" id="ENOG502SAMI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_956828_0_0_1"/>
    <dbReference type="OrthoDB" id="27934at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018468">
        <property type="entry name" value="SFR1/Mei5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28527">
        <property type="entry name" value="MATING-TYPE SWITCHING PROTEIN SWI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28527:SF1">
        <property type="entry name" value="SWI5-DEPENDENT RECOMBINATION DNA REPAIR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10376">
        <property type="entry name" value="Mei5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="33219" checksum="234155C1794A70FF" modified="2013-05-29" version="1">MDSEIEQLNSPYKKELIDTNNDTKVALDKETGSKRLYSEIEDKDNLDDKKSPVLSKKACFSMKKLKQPFRSPLKVNSSVATKSLEVKKNYDVPKTIENSFIVEGNENVEPISTSHGSESATLISKASVKKTAFRSPLVSSKNITDPNISALYKRKLELERKIWEVDEHIKTIETAKMYENKDDSKLERLVDKWRLAAQQAATQLFAIVSEKIESVGGISAWYRQFEESKSILSEWDPPPKPEIEDTDYDREDSRNIEEAPQPEVFTMAIMLQKLNIPPELIGWDAESETWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVI1</accession>
    <name>M7NVI1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00315</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Essential role in cell cycle control. PP2A may be involved in controlling the entry into mitosis, possibly acting as an inhibitor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872189.1">
        <property type="nucleotide sequence ID" value="XM_007873998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVI1"/>
    <dbReference type="STRING" id="1069680.M7NVI1"/>
    <dbReference type="GeneID" id="19894013"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00315"/>
    <dbReference type="eggNOG" id="KOG0371">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_0_5_1"/>
    <dbReference type="OMA" id="CMKVRYP"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="134"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00057058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="329" mass="37663" checksum="DF75B2FB8EF46A6C" modified="2013-05-29" version="1">MEDIRMIDSDIKLPLALGNINESLESINEVDGWIKHLMQCKQLSEVDVRRLCDKAREILQEESNVQPVNCPVTVCGDIHGQFHDLIELFRIGGNCPDTNFLFMGDYVDRGYHSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKSFTDLFDYLPLTALINDQIFCLHGGLSPGIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDRCGWGISPRGAGYTFGQDISQAFNHNNGLTLVARAHQLVMEGYSWSQERNVVTIFSAPNYCYRCGNQAAIMEIDEQMRYTFLQFDPAPRAGEPQVSRRTPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVS0</accession>
    <name>M7NVS0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Casein kinase II subunit alpha</fullName>
            <shortName evidence="10">CK II alpha</shortName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_00420</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872298.1">
        <property type="nucleotide sequence ID" value="XM_007874107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVS0"/>
    <dbReference type="STRING" id="1069680.M7NVS0"/>
    <dbReference type="GeneID" id="19894118"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00420"/>
    <dbReference type="eggNOG" id="KOG0668">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_70_4_1"/>
    <dbReference type="OMA" id="ECHMIEW"/>
    <dbReference type="OrthoDB" id="10254671at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006356">
        <property type="term" value="P:regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000059">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="34"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR11397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="329" mass="39223" checksum="7FEF4B8DC0446D1D" modified="2013-05-29" version="1">MSIARQYANVNENMQRSYWDYDNLQIQWGVQDNYEVVKKVGRGKYSEVFEGYNVSSNEKCIIKVLKPVKKKKIKREIKILQNLAGGSNVIALLDVVRDPQSKTPSLIFEYVNNTDFRNLYPRFQDYDVRYYIFELLKALDFCHSKGIMHRDVKPHNVMIDHEKRQLRLIDWGLAEFYHPGTEYNVRVASRYFKGPELLVDFQEYDYSLDMWSLGAMFASMIFRKEPFFHGSDNYDQLVKIAKVLGTDKLYAYLDKYDIELDSQYDDILGKYPRKPWQKFITQENQKYISPEAIDFLDNLLRYDHQERLTPQEAMNHPYFEPVRRKEQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVW4</accession>
    <name>M7NVW4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Wbp11/ELF5/Saf1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872353.1">
        <property type="nucleotide sequence ID" value="XM_007874162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVW4"/>
    <dbReference type="STRING" id="1069680.M7NVW4"/>
    <dbReference type="GeneID" id="19894168"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00470"/>
    <dbReference type="eggNOG" id="ENOG502S9RI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_994521_0_0_1"/>
    <dbReference type="OMA" id="MPKERNF"/>
    <dbReference type="OrthoDB" id="5597581at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019007">
        <property type="entry name" value="Wbp11/ELF5/Saf1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12622">
        <property type="entry name" value="NpwBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09429">
        <property type="entry name" value="Wbp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wbp11/ELF5/Saf1 N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR11452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="293" mass="33963" checksum="C9A8C1AD85FFB1F0" modified="2013-05-29" version="1">MPKEKNYNPAQEFHKKRKRDHIKKAKAEKQKLQYEKLARRDVNKIETQIQEFKRLEMKGQLSALDQSNLKILESDLKRIKKARKYIGPIIESEKTKAREAKEEKQQQKIPKNPEKSIYYDPIYNPYGVPPPGMPYKEWSDIEDDETSSNEPSTPESVSIIPMPKGSPPPSSYLDKRKKKHQLERFKHPKTLNEKTNTLHSSHLEKQFKNDNSIEGSSQPTSTPTIVYSADCILRDLRKESTTFVPTAVRQRKIPQHPSLKKNIIPKPAFKQNPVFKPKPNIHINAAPDILDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M7NW98</accession>
    <name>M7NW98_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872312.1">
        <property type="nucleotide sequence ID" value="XM_007874121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NW98"/>
    <dbReference type="GeneID" id="19894132"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00434"/>
    <dbReference type="HOGENOM" id="CLU_918663_0_0_1"/>
    <dbReference type="OrthoDB" id="5410947at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="303" mass="35759" checksum="7A2C4F41B84567AF" modified="2013-05-29" version="1">MRFIRVTHVIWVKRRIRCISTRTFEIQTIGALTRKAEETNLLKIQEIPVKNKENVKKSLLERLKGKKINILAKPLMPGILPYDESKVSRGLKNGVLKKDYMGFPWPDEAKYVDSDLAFYEDLSTEKKDMKTIKKCLEYDNLSVSLKDSDRELSIKSKKNIKEENKMLKDEFNLKMDDYEKNQRIYRSPIIRKGHSKLDMFVSRLEFVSKEDLDPYMPDWVISSKKINILKSKDSVPKQFREMDKELKKMNVKSNEGNLDCKNIFYMNDSTFFNNCIYKNSSIKPNQKIEMINIINEMIKQKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWL1</accession>
    <name>M7NWL1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00550</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872442.1">
        <property type="nucleotide sequence ID" value="XM_007874251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWL1"/>
    <dbReference type="STRING" id="1069680.M7NWL1"/>
    <dbReference type="GeneID" id="19894248"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00550"/>
    <dbReference type="eggNOG" id="KOG1612">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="INKRWHW"/>
    <dbReference type="OrthoDB" id="272245at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="8">
        <location>
            <begin position="30"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="305" mass="33789" checksum="0BA85ADFFF3F35D4" modified="2013-05-29" version="1">MQLSSSQLSYLYSSLFQVPTIRPDARKSTQFRPLFAQINVLPLTYGSSCIKWDDTHVVVGIKAEIIDALDLQTLHECKKGGKISINVEIFPDASQENCEDDSMSAFLTQSLQQFLSGIRPECLLVTSTKAWNIFIDAVVISSNSHSLPALSLAMYLALQTARLPHIIAHIAPENMKFREDIQNIGSGEFEVDYDLKNSVPIPDIEKVGVVIFVGNVGENILYDLSADEMAVVEGLLAVGVLQNGQIAYTRRICISGTYKRSCLKHSIIKNMLKGAAIMGKELIRKSKEDIINQANNNQIGFLYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7P2Z6</accession>
    <name>M7P2Z6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ataxin-10 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Copper transport protein 86</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_03389</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a role in the regulation of cytokinesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ataxin-10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875473.1">
        <property type="nucleotide sequence ID" value="XM_007877282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P2Z6"/>
    <dbReference type="GeneID" id="19897076"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03389"/>
    <dbReference type="eggNOG" id="KOG2676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_561533_0_0_1"/>
    <dbReference type="OMA" id="CEICRIL"/>
    <dbReference type="OrthoDB" id="379794at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051374">
        <property type="entry name" value="Ataxin-10/CTR86_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019156">
        <property type="entry name" value="Ataxin-10_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255:SF0">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09759">
        <property type="entry name" value="Atx10homo_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ataxin-10" evidence="7">
        <location>
            <begin position="389"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="486" mass="56731" checksum="B774EFB85916BB66" modified="2013-05-29" version="1">MYKYRRFASKSSHKLCNRLYPKYSLPVDKQNELDILEAISEDIVKLHKRLDICGRLNHISICFDPVYYGDNVFLYGLDLAGNTNTCIFYKACEICRILEKAIRLHIDVYKRVNEEINVISGLEKLSCLETCVFRSLCVFDDLISLNYVEKGMFLIALFKVLDSEILEWFCFGGHKKEMNALLVFLNDLFRDNSSVCDILFNNDMGKEMMILFFSFSEKMYMDEISNNFELLQSLFFSFIQNDKVHELFVLMNKSGFQISDSQLVFLKFLNTFLSNYTNQKIIISEKMCEFIESMLNLFCLSMVEIVKTQVFDSNQIFIKSQKILKATEILISCAFHVSKNSKEKQLLLKNDLLKSLINLLQSIDDYSMTQNKTSKILSNNSNKVSFPYFKRDIIQLLSTLCFRNKKVQDDIRELHGLGLILSQCRIDDENPYLREYAIFCLRNVLEDNEKNKELLRNMKPIGLQNSEITDKLGLTLEIMNKTRISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3H8</accession>
    <name>M7P3H8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-4-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.68</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-phosphatidylinositol 4-phosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphosphoinositide kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">PIP5K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_03227</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14425"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.68"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.68" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875293.1">
        <property type="nucleotide sequence ID" value="XM_007877102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P3H8"/>
    <dbReference type="STRING" id="1069680.M7P3H8"/>
    <dbReference type="GeneID" id="19896914"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03227"/>
    <dbReference type="eggNOG" id="KOG0229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004312_6_0_1"/>
    <dbReference type="OMA" id="NSNMKER"/>
    <dbReference type="OrthoDB" id="20783at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052811">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902635">
        <property type="term" value="P:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17303">
        <property type="entry name" value="PIPKc_PIP5K_yeast_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase its3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="12">
        <location>
            <begin position="212"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR08390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="618" mass="70838" checksum="F413A4E657B09A72" modified="2013-05-29" version="1">MGFKESDSLLDDYLSEQSINKFCISNGCDKSYESVKCFEELLEKDRNGEMMTRCKLSMGFPRFLDNMTCFRKNAPNYDTVSTISINVSDTQHKSKISDKCSNVSKSVSCNEQDLKEQNDLRFITSNVHDNKIPDAIAVENKVASSEGCSVDNALGVGLGSQNVTCVSLDVREESTAQEPVKWIETIWQKRSSKHKRKQNEENQGYFIGTRIGEDHVNYVTAYNMLTGIRVGVSRCTAKVDRDLTSIDFVDSYKFSFDITGNELTPSAKYDFKFKDYSPWVFRHLRALFRLDPADYLISLTSKYILSELGSPGKSGSFFYFSRDYRYIIKTIHHSEHKFLRKILRQYYEHVKKNPNTLISQFYGLHRVKMPYGHKIHFVIMNNLFPPHRDIHKTFDLKGSTVGRDYKEDDLEKNPRATMKDLNWIRRKMYLSLGPEKRDIFLAQVKADIELLESLDIMDYSLLVGIHDLSLGNKEHIRGNMLSVFNPDSEQIHSSLKQGQTVSSANELRKIVSTIGPVSLNSTSNELSDPDFTRKDFIFYSDDGGFRATQEDNLPGDSIYYIGIIDLLTKYNIVKKVEHFWKGLSHSKSQVSAIPPSGYASRFFKFISSIIKTHQSVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3K3</accession>
    <name>M7P3K3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BolA protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08425.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613286.1">
        <property type="nucleotide sequence ID" value="XM_019757752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P3K3"/>
    <dbReference type="STRING" id="1069680.M7P3K3"/>
    <dbReference type="GeneID" id="19896948"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03261"/>
    <dbReference type="OMA" id="VHAFSQK"/>
    <dbReference type="OrthoDB" id="4983at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990229">
        <property type="term" value="C:iron-sulfur cluster assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071281">
        <property type="term" value="P:cellular response to iron ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045115">
        <property type="entry name" value="BOL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735:SF27">
        <property type="entry name" value="BOLA-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735">
        <property type="entry name" value="BOLA-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08425.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="10398" checksum="073439F323FC7E72" modified="2016-03-16" version="1">MTARITAKKIEQALKERLDAVEAIIQDVSNGCGTSFRCKIVSERFANLNILARHRLVNNALKNEIDSLHAFSQEDYTPEEWNKLKENNVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3L3</accession>
    <name>M7P3L3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Metal homeostatis protein BSD2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_03267</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875338.1">
        <property type="nucleotide sequence ID" value="XM_007877147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P3L3"/>
    <dbReference type="STRING" id="1069680.M7P3L3"/>
    <dbReference type="GeneID" id="19896954"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03267"/>
    <dbReference type="eggNOG" id="KOG4812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041193_3_0_1"/>
    <dbReference type="OMA" id="NTHQAES"/>
    <dbReference type="OrthoDB" id="10003116at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22212">
        <property type="entry name" value="NDFIP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019325">
        <property type="entry name" value="NEDD4/Bsd2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13396:SF5">
        <property type="entry name" value="NEDD4 FAMILY INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13396">
        <property type="entry name" value="NEDD4 FAMILY INTERACTING PROTEIN 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10176">
        <property type="entry name" value="NEDD4_Bsd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="36"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="34376" checksum="CD8B0A4FF106D725" modified="2013-05-29" version="1">MIKKYYEDKDKHHDEITETLYESSEDIMKSIFPFTDTDGHENLGESSSTHLLHKNNNKKEESSLEFENKEENEGMQVKDKNKTRKPYRSSFALRFLPRYTPKLNQNDGVFANLNAKPDISKQMKEEFPPSYEQAAADATPSYWENTMIAPGISADEVFIDGLPVGNIFGFLWNMLISFSFQFIGFLLTYLLHTTHAAKNGSKAGLGTTLIQYGFYMRSIKDNIFDQDNSDANSENDNQAYQNDSLDHIIVSYLLMITGWFLLIRSTTDFLKARRIEMCVKETSSSSDTPQASQTETPEVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3R8</accession>
    <name>M7P3R8_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_03330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875407.1">
        <property type="nucleotide sequence ID" value="XM_007877216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P3R8"/>
    <dbReference type="GeneID" id="19897017"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03330"/>
    <dbReference type="HOGENOM" id="CLU_785553_0_0_1"/>
    <dbReference type="OrthoDB" id="10606272at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082615" evidence="2">
        <location>
            <begin position="19"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="353" mass="38193" checksum="5984225BA8FE882B" modified="2013-05-29" version="1">MKIPILVVFFGIIHVLSGKVQISEFAEDVSDSFLSDADELNSNIASPYDSARLRGIPVGDIEDFSEYFGEDVSGKQYLRGSYLTRKSPVQDRVTFRPSSSSSGVENVHTRIVDETLYETKTVYFTHTEAAVVTKCCKQKPHYTKCSSTDLETTPASSPAVPDTSSVCEVQTVTSECNVPTVTSECNVPATTNECGVSEAGCCHSKPGCKYSATIIVTANCNYPSVTLSDKCGYSVVTSVGSDGPSVVKHRALVRSLIGDASYLTEQKSESTLTASSLLSGKDDKDHASETLSNLDTRADTHKDDNGHDDKTHEHNKNDTVKGSNKNHGTRMEKLKEIELACIIVGVILGIWIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7P410</accession>
    <name>M7P410_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS9m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">37S ribosomal protein S9, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_03076</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875132.1">
        <property type="nucleotide sequence ID" value="XM_007876941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P410"/>
    <dbReference type="STRING" id="1069680.M7P410"/>
    <dbReference type="GeneID" id="19896763"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03076"/>
    <dbReference type="eggNOG" id="KOG1697">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036531_0_0_1"/>
    <dbReference type="OMA" id="RESAMWA"/>
    <dbReference type="OrthoDB" id="10254627at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_uS9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001099">
        <property type="entry name" value="PRK00132.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="287" mass="33480" checksum="499D8726699BDC74" modified="2013-05-29" version="1">MVYKCLMRTVDLFHGPIVYSNSCLILPIQKALRRFKDFRYIGYTSFYEPVSSSYFTAKEGFHDDFLSLESILKRYQTLPTVSFEEAPKRLWKTLNQYRESRNIVECIKPSEYRKIIQLLVRINRIDPIFMPEEVKEVLDKYSREISVKSKRKYTASLDALGRSRTIGRRKEAVSSVWMIKGDGQVLVNGKAFYEAFPRLFDRQSVIWPLKITQRLDQYNLCIFVKGGGSTGQAEASALAISRGLVIHEPELRYLLRKNSCLTCDARRVERKKPGQPKARKKNTWVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7P4P2</accession>
    <name>M7P4P2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tafazzin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_02950</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:33731"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64743"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:33732"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:33733"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the taffazin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874995.1">
        <property type="nucleotide sequence ID" value="XM_007876804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P4P2"/>
    <dbReference type="STRING" id="1069680.M7P4P2"/>
    <dbReference type="GeneID" id="19896637"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02950"/>
    <dbReference type="eggNOG" id="KOG2847">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046747_1_0_1"/>
    <dbReference type="OMA" id="FNTRIRW"/>
    <dbReference type="OrthoDB" id="193467at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000872">
        <property type="entry name" value="Tafazzin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497:SF0">
        <property type="entry name" value="TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497">
        <property type="entry name" value="TAZ PROTEIN TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00979">
        <property type="entry name" value="TAFAZZIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="13">
        <location>
            <begin position="5"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR08780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="206" mass="23699" checksum="C41D8A49E01E93D8" modified="2013-05-29" version="1">MFEKLDDPLLWATFPFRTWFNTRIRWSLAASDICFTNRSASLFFSLGQTLPIVRYGAGPFQPSIDDAIRLISDPICAWVHIFPEGKVYQQPECALGIFKWGVARLFLEAAQRSTRLPAVVPVFFHGTQYLMPETRGFPRWIPRLGQGIEARFGAPIQDKLKPFVETWKKLGSDQTKSTIFHDNIRSLLTAELRKHVNRLRQEAGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7P4Q8</accession>
    <name>M7P4Q8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02969</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875015.1">
        <property type="nucleotide sequence ID" value="XM_007876824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P4Q8"/>
    <dbReference type="STRING" id="1069680.M7P4Q8"/>
    <dbReference type="GeneID" id="19896656"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02969"/>
    <dbReference type="eggNOG" id="KOG1472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006198_0_1_1"/>
    <dbReference type="OMA" id="YRRSEAK"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05510">
        <property type="entry name" value="Bromo_SPT7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037782">
        <property type="entry name" value="Spt7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="8">
        <location>
            <begin position="278"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="947"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="947"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="970" mass="112153" checksum="3590AF4EDDDF6A84" modified="2013-05-29" version="1">MIRIEKLWTSTDPELLRHLALLIKEKEQWYAYLTPLEGKCFLSCLDDPILWKEFIDFKPNVAEMSSSTEILEKLTVLFRVRFMLYDKAIESFIFFNDKDVFGVDKSLLIQCLNNYEKRKNEMYDFGTVRLLEDNFYDMYDEELEDQSSCSKKADIKEYKTSKINQQIGAFFNRVYYTLDNDKDAMIEHKLDTSDQLDFAEISSDEDISVTSNLEMENISLKYLLSAIESKRLVMAISDLELRNLLSEVWKSKSKWTSEENLGHELYDAAKKVVLELKAYTEHSTAFLNKVSKREAPDYYDVIKNPMDLGTVMKKLRNFQYNSKKEFVDDLMLIWSNCLIYNADPAHFLRKHAIAMRKKTLSLIKLVPDVVLYDRNKTNVEKNDLNDDDLELYDDETLQKLKTGTSSVKKTFSSKPIKTKDPEMDLSETYLSSNIMKTDSLLLKNNTEKVINDANMFNREYASSFNGVGSLSSIQKIEHDNDDVVYQAWKTLTKKVRAEICTIRHKLLKGDKLKGNAVAVSRSSKSMIKFQEWETGCSKNNDLNNYLNYELSGNFDSEKNNVEENWSESSYLILYNVCSGLPRIPIMNDEFYNSKSDTFQDYLFIESNPRFLPPPEGICRKIYKNIEDLRSIRKLCNKVYALKMMQQASSLYYTCFRTPEEQRPLNLEIQNKSFNLFNCIEVMSEELGFCLLGKFVSTLLYHVGFEEYQSRALDVLVDIASSFLLKLGKTLKLYLENMSDKSIEENLLHALYENGISDISLFESYIKDGIDRYSTKLNDIQRRLQAYLNETIKPSLSYFDEENLENNDSFIHGDFAEKIGEDFFGFKELGLDKEFGLSSLLVPLHLLHGKVQLGPGVSDPVNITKQETKHIPPSKFEPVTLDVIERQIGLVQPFLKSKLLESGGNKLIEDEDLFIKQKLRLPPNGKIITPLKKIGTVALNLSKKKKKLLDAKNNDSDAKKPKNEETIFPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7P5F2</accession>
    <name>M7P5F2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Anaphase-promoting complex subunit cut9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02454</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874463.1">
        <property type="nucleotide sequence ID" value="XM_007876272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P5F2"/>
    <dbReference type="STRING" id="1069680.M7P5F2"/>
    <dbReference type="GeneID" id="19896147"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02454"/>
    <dbReference type="eggNOG" id="KOG1173">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011751_4_0_1"/>
    <dbReference type="OMA" id="DPFHNNA"/>
    <dbReference type="OrthoDB" id="10006270at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032297">
        <property type="term" value="P:negative regulation of DNA-templated DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF9">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="193"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="366"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="509"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="543"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="618" mass="70535" checksum="F2830F34F5996758" modified="2013-05-29" version="1">MRRKISRASNSTTPANHNTSLYGECLMSGRLQDPHQSTLTISPLTNIYAYDGSPTMAMSSMYSHGSLSNTLHTYSRIERMRLWRHDALVQHQHETAAYIGDKILGLTNDPNDAFWLAQVYYHTGHYARARGLLMNRYLLDSSVACRYLAALCLSKLSKWQEALDLLGEKNPFRQEGSDETVIKNQDGGIKFEASMCYLRGVLFANLNKFDKAKECYKEALTIDAKCYEAFEQLISNNLMTAEEEWSFIQTLNFNGLIEEDVDFVKSLYITKLNKYKNALRFIEAETKLKNTYNLHDNTDLLLSKAELLFVQNRFRQCLEVTEKILSIDQYKFNALPIHLACLHELNEKNKLFLISHDITERHPEEPVSWLSVGIYYLCIGKVAEARRYFSKASMMNPHFGPAWIGFAHSFAVEGEHDQAISAYTTAARLFQGTHLPSLFLGMQHLQLNNLVLANEYFNTAYDLCKTDPLLLNELGVVAFHRLQLPEAINLFRSALTLAKETDSEERSWIATWANLGHAYRKLRMYDDALRYFSEVKRLSPRDPCVYAAIAMVHLSAHRAGDAVQYLHEALSLAPSDPIATDLLRRALEENAQFPFEIETNIQDISSDDDNILASINNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6Z6</accession>
    <name>M7P6Z6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dolichyl-phosphate beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_01855</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-alpha-D-glucose = a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:15401"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15402"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.117" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873826.1">
        <property type="nucleotide sequence ID" value="XM_007875635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P6Z6"/>
    <dbReference type="STRING" id="1069680.M7P6Z6"/>
    <dbReference type="GeneID" id="19895549"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01855"/>
    <dbReference type="eggNOG" id="KOG2977">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_9_1_1"/>
    <dbReference type="OMA" id="HMVNTDA"/>
    <dbReference type="OrthoDB" id="3784at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004581">
        <property type="term" value="F:dolichyl-phosphate beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859:SF91">
        <property type="entry name" value="DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859">
        <property type="entry name" value="GLYCOSYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="14">
        <location>
            <begin position="71"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR09665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="326" mass="37700" checksum="0D1149CBC01C3FCF" modified="2013-05-29" version="1">MAISLKNIWSILIIAICFILLLFFAIVLLLIFSKQRLSYQSELYCKVISENGEFNKVLLNTLEDPAEVFLSVVIPAFNEKLRLSKMLEDAVEFLSFELEKDQKWEIIIIDDGSTDNTYEYSVEWALSKSKSSLLKHGEIRVSSLEKNRGKGSAVTHGMIHSRGEYIIFADADGASRFSNLYNLLKEIKKIERHGYGIAIGSRSYTASSDIILKRSKIRNFMMHVFQKYLWFMGIRHIKDTQCGFKLFTRRAALMIFPNMHVEKWIFDIEVLILAEIFLIPVVEVPIAWQEVSGSKLSLISDSLRMAIDLLIMRLNYKFGFWKIKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7P754</accession>
    <name>M7P754_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TFIIS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873866.1">
        <property type="nucleotide sequence ID" value="XM_007875675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P754"/>
    <dbReference type="STRING" id="1069680.M7P754"/>
    <dbReference type="GeneID" id="19895586"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01892"/>
    <dbReference type="eggNOG" id="ENOG502S92D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_330408_0_0_1"/>
    <dbReference type="OrthoDB" id="5365845at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="868" mass="97887" checksum="93A01B92159A4AE9" modified="2013-05-29" version="1">MNLSDSNISTELSTSSHVTAFSGLKDNEDDSSSNLETTYPENISLDNTLLLKNSLSNTLSLEKPLENVFRSNNMLNNVLNSLSKNVIDTPVLLTSALQAPTLQTNMETQKSTSLNISSNLPLNAVYTHKKDQTIDFLANDSKHIFEEMVQRKQKKELSDAMYNKKINSNTSTLSNKISNHNMDILLDDKTYDSCDYNTDFSKYYETNENEDEISQESKNIPFKFPGIPIPNLPFATIMDTQADNLHLEKTTIQNKVNIIKKNETPILKNQLRPKDPEDLLRYELRKCFSVYAVTGDTRSCVRTVYDLMKDIVEDKTKIAMLEILKGGIKDDIVEAFIENKQVLGRIRNWLVNAINEKKNMVIIAILKIMNILKLDSSILAELKMGKPIIILAKKSENETVKQLSIKWLEAAEKSLSLEKPIENSTAVNVPPISMTEDTSKKKQKTVSNDPVFKSSVTPKPTSTKPVVKSQKVQAVANTDFFKNLSTSTAKASQKPSLSSVLAQIKAPKKQNTTQPQVIETISSISKKFTSVLEEVPGCQPTPETITPNTNIVLDDVPKKKRKCVSWKSDDTLVEIRVFEPIEPEDTDDTYIHISREFKNARDLDIYEGRAAFSKTHNIEDDMMTWREPEDIDFSHLESQLSKLGPKRGGISKCDSDEYKIQEERERFVFLVSYLYEKDIPHSPTEPNANSDGFFTETKIIPLPSDMKDLHTSDYLFQHNQGSANNLSFSNINQNTIPLTNSSSFNNTQANITSILQNLLNASGQATLNNPSSIPSVPQTMQYFPLPSSTFSPVNIANITNILQILQQTQKKPLQSSLPTPTVSSTASPFNFNALLGGQQKNLSYTDWNERNDISRSRDKRHRTQRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7P775</accession>
    <name>M7P775_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ubiquitin-60S ribosomal protein L40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_01906</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. eL40 is essential for translation of a subset of cellular transcripts, including stress response transcripts, such as DDR2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873881.1">
        <property type="nucleotide sequence ID" value="XM_007875690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P775"/>
    <dbReference type="STRING" id="1069680.M7P775"/>
    <dbReference type="GeneID" id="19895600"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01906"/>
    <dbReference type="eggNOG" id="KOG0003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010412_3_4_1"/>
    <dbReference type="OMA" id="CGRCSQL"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000014">
        <property type="entry name" value="Ubiquitin-60S ribosomal L40 fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.50:FF:000001">
        <property type="entry name" value="ubiquitin-60S ribosomal protein L40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001975">
        <property type="entry name" value="Ribosomal_eL40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="Ribosomal_eL40_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01020">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01377">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 12" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="11">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR09720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="128" mass="14587" checksum="8572BF89FB94734B" modified="2013-05-29" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGIIEPSLKALASKYNCEKMICRKCYARLPLRATNCRKRSCGHSNQLRPKKKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7P781</accession>
    <name>M7P781_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="9">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01910</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="9"/>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873886.1">
        <property type="nucleotide sequence ID" value="XM_007875695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P781"/>
    <dbReference type="STRING" id="1069680.M7P781"/>
    <dbReference type="GeneID" id="19895604"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01910"/>
    <dbReference type="eggNOG" id="KOG2467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022477_0_0_1"/>
    <dbReference type="OMA" id="CATTHKV"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF28">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="10">
        <location>
            <begin position="37"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="488" mass="54651" checksum="220E653E12537A7C" modified="2013-05-29" version="1">MYPYCRIVNLFPRVNGLRLQKLYMSLSSNNSLLSTPLSKSDPEVDNLIKLETKRQLESIVLIPSENFTSQAVLNALGSPMQNKYSEGYPGDRYYGGTMYIDQMELLCQKRALDLYGLNHEEWGVNVQPLSGSPANFYVYTALMKPHEKLMGLDLPDGGHISHGYSTTFKNISAVSSYFSSVPYKTNPKTNIIDYDELEVLSKRVMPKIIIAGTSSYPRLLDYSRFSKIAKNVGSFLMADMSHISGLVAAGVVPSPFDYADIVTTTTHKSLRGPRGAMIFFRKKIKKLDKNGNEVLYNPENHINCSIFPGHQGGPHNHTISALTVALKQAKTPEFKEYQKQVLKNSKAMSDRFIELGYELVTGGTDTHLILIDLTKKGIDGARVEKVLELANISANKNAIPSDKSPFTPSGLRLGSPAMTTRGLKENDFLKIVDFVDRAIKITINIQKICQSKKLIHFKEYLGTGENITELHDLKNEIIDWVSNFYIPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7P7B3</accession>
    <name>M7P7B3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01935</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873911.1">
        <property type="nucleotide sequence ID" value="XM_007875720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P7B3"/>
    <dbReference type="STRING" id="1069680.M7P7B3"/>
    <dbReference type="GeneID" id="19895629"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01935"/>
    <dbReference type="eggNOG" id="KOG4510">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032828_4_3_1"/>
    <dbReference type="OMA" id="QIIFIRM"/>
    <dbReference type="OrthoDB" id="306876at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="6">
        <location>
            <begin position="24"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="6">
        <location>
            <begin position="191"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="356" mass="40900" checksum="D25019F1CEB87EE6" modified="2013-05-29" version="1">MKINTYFNKIKIFFNKYYGIAILVLSHTLFSTVNASVKMLYQNSVRSWNSFQIILIRMIPTYILTIIYSRCVGTIEKSATNLNVRFFLFLRGFFGFIGICCTYYSIHHLDLSDATALSFLNPIFINLLGHPILYRTFNFFDIYAALVSFVGVMFVVKPGFILNNRFFRTFHNNHSASEIISSANSKERAFTIMISLIGVLAICFSYIIIKSLGDSINSLQPILWFSLISSIGSILFLISFNIPFHLPLNFLELFLFFVIGISGFFAQLFLTRGLQIEKIGRASSVIYLQIIFSLFYDKVLWGKFPDIWSFCGIVLILIGTAMTIIDCSKENKSPDHKPRYIYLHQLKSDELLEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7P7Y6</accession>
    <name>M7P7Y6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01748</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873712.1">
        <property type="nucleotide sequence ID" value="XM_007875521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P7Y6"/>
    <dbReference type="STRING" id="1069680.M7P7Y6"/>
    <dbReference type="GeneID" id="19895442"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01748"/>
    <dbReference type="eggNOG" id="KOG1118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034817_1_0_1"/>
    <dbReference type="OMA" id="EACESIY"/>
    <dbReference type="OrthoDB" id="14167at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="2">
        <location>
            <begin position="13"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="481" mass="55723" checksum="39B0AF6CA359DC34" modified="2013-05-29" version="1">MQKKIGRLGQWTKEMLGKEQRTQTTDEFKELEQEMQMRHEGIENIYSSINQWAKSMLNRREDKKHTLIDLFSQALLSFGEKFSPESVYGQGLLKYGIAHKEISKEQERLINGISNNILESMERSLVQFKDYQTARKKLESRRLSYDSVSNRFIKAKKEDPRIEEELRAAKAKYEEACESIYGRIYSIQQAETTQLNDLTFLLDLEFRYYEQCYMIIQNLKESWAEINNAYEASSKYVKHQQISAHAFNNGGENTINRLSLPFRSGMSALSLERKISEIDLNSPKQISSFRATPTRIPPESPNSIEDKNTQDTASLKLEQSFKTDEQDASILSNGNAPVIPPRTYERFDRKDNTSSTKHYSTLKNSSVRNFYTTYKNVSEDNSLSSDENKNIYSENHLPEFPNTFSNSDDPTLKSYSDSKSTSKINTLEFPIIKTRKPPIPSQFLQDIDSSKLNNTCKNCNCDDYQESFFKKGQCNQCFHIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7P813</accession>
    <name>M7P813_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873737.1">
        <property type="nucleotide sequence ID" value="XM_007875546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P813"/>
    <dbReference type="STRING" id="1069680.M7P813"/>
    <dbReference type="GeneID" id="19895464"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01770"/>
    <dbReference type="eggNOG" id="KOG4574">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_303667_0_0_1"/>
    <dbReference type="OrthoDB" id="2017782at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052645">
        <property type="entry name" value="Pumilio_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093:SF1">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="369"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="PUM-HD" evidence="5">
        <location>
            <begin position="498"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="559"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="595"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="980" mass="111905" checksum="59692BBA227BF538" modified="2013-05-29" version="1">MTTSSSSKPTSLDIGRHNTLENVTNIHSIDSDGSCLMKRTLEVQKQNKEISWISPFLDESVKFFKNSCFDDQRGDKLHLSRTSPILTSEEKGISEVGYSSSEGTQRFRRERAETMPVDTLGGYESSYSVSLKAKDFKMTMESSVVPSIANSRFRSGSLTLYDRNMYTSGFDPFVFSLDWKQILDCQNKISNTSSISSKDEEGQGPIKTLDYLGLADSSTPIVMSESFKSCDSVSEKQNNKICMSNINSLKNDSNRIRSCSVSGSKIYEKGYDSSLDVNQENLPSKSIDYSDSYDTLYQNHSDLYLRPRARTTGVINFSLNHMDNQGLNSQPYVHESPISDNNIPNNIASSSYDNINESEYGYIMSFPTRSLWIINLPLTASNSSLTALFSQFGMVESIWILADKKYGFVNYNTLESAIQAKNSLDGKELFPGNDLIRVEYIKTLKNPMNMQISNTYPYRPKISEYKSECFFSPVFSRPGDLKSLVTEIAMNYAATQEEADKIWGDIQNIGKVRDYAFEIPPVPEPSLNRQFHGSRLKEIRKKFDNSGYTQKEIEDMANDMIDEVSELSSDYLGNTIIQKLFEHCSEEMKEKLLKRIAPHLSGLGIHKNGTWAAQKIIDLAKTETQINDIITHISPYIPLLFLDQFGNYVVQCCLKFEAPMNNFIIEIMADRCWDISQGRFGARAMRACLESNYVTKEQQRYLAVIITLESHRLATNPNGLILLTWLLDSSAFPNRYKMLALQFVHHIVYLCTHKLASSIILRIINQKMDSDARKILLNTLFFSQNGQILDEVLSEEHYGVDTIFRIFTVAYLEDDLRENISIALKKAFSQLKIVPGQQYKTLMDEIGLNHNSLNLVSKNPDLSKIYHSKKDKKYDSSMPYSEFKNIQLHGSASLFPRPFFSDYYKSLNTANNNLYPLHYHTISQQKMNLQHYDMSYIQQSEIPHHSFSYINSFYNEQYIPNGYSCSLPLSLFNFNSHRNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7P8T0</accession>
    <name>M7P8T0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873455.1">
        <property type="nucleotide sequence ID" value="XM_007875264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P8T0"/>
    <dbReference type="STRING" id="1069680.M7P8T0"/>
    <dbReference type="GeneID" id="19895209"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01514"/>
    <dbReference type="eggNOG" id="KOG0565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002027_1_1_1"/>
    <dbReference type="OrthoDB" id="2248459at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF240">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE 5-PHOSPHATASE C9G1.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="757"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1166" mass="134051" checksum="9796090136307BF1" modified="2013-05-29" version="1">MGIIEEEKTVSRLKEKFERLAIEQRHNGQYRPLREQERCIKTLPAYYRSYERSIKLPVEEKLKYERSYIKVSNNDKRSEIRSSSYFESSLKSPYHIENIFDDPDITIPDTNQNSMNADISPAKIPLMSFSDTASYHSDIFRDDPHVGTSSFKNNINHDPDLTTPSRSPTIPVKIQSKKQKEYHNDPYFDHFTVEHTNSFLSSKIDDYIFESQNILPDIANSPFDDSISSSFDNVSIKKPLLSHEYMDPIIDDFFHNDNISNIAPSEFSEATFNKISKHDKNLDINDIEISNKLGESQSKLSRSISPFKNAPCIPPKPNDILKARANKPFNFTEKPLKPKKDIVDRHDLFKGHMKSYSMSTRLPGGESFSYPPADFRYSSVSLTASSVIDESKSDLGEKTVKCSENQPTTDYPDSSQTNRRQPIFKNGPLEIRGRSEIKHFLVSGDYLCSCGTIIKVWNIKTGEHIWSLPCTDMKITSMSFVPCRNVDEEGTRIWLGTKDGHILEINIFYQGFVDKRFGIHSHPIIFILRCGYELWTLDDSGKLLIWSDDTHKNGLHLQSTPRTYKVVAKASFCFVVKNQLWLGVSRSVYVYNPLAYLNKLPFIATNRPIVPHLPVGEISCGAFLRDQPDLVYLGHQDGKISVYSRTSLTCLDVINVSLYNIVSLIGVGNYLWAAFKTGMIYVYDLQSKPRKVMKGWWAHKFPILELQLDTTSIWKVKRCQVVSLASDNIIRIWDGLLMEDWLENEMHKRDEEFCRFRDINITVCTWNAGASRPNDLNSSTDDFSFFEKVLQSPNPPEIIVFGFQELVDLENKRLTAKHLMKFNKKKDPKQFQEHMSCQYSAWKDRLSNEIITYLHSEFQYSLLHSENLVGLFTCIFTKTSIKPNIKKLNSVQVKTGLGGLHGNKGALVVRFILDDTSLCFINCHLAAGKSQVVDRNNHLATILESSDFPPELDNSKRADLFVGGGDGSMILDHEICILNGDLNYRIDMCRDAILDHIRCKDYQSLFEKDQLILQRKRNPGFRLRLFNEAEINFPPTYKYDIGTDEYDTSEKKRSPAWCDRIFYRGDSRMKCTSYRQLNVRISDHRPVVATFSIKVKTVDPVKKKDIWKMVANDWMNTAQSFRELAKLDYLVSECGFEEKLAFKILNNHNGEVSNALTELLNSTYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7PB52</accession>
    <name>M7PB52_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872612.1">
        <property type="nucleotide sequence ID" value="XM_007874421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PB52"/>
    <dbReference type="STRING" id="1069680.M7PB52"/>
    <dbReference type="GeneID" id="19894410"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00712"/>
    <dbReference type="eggNOG" id="KOG2009">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_821643_0_0_1"/>
    <dbReference type="OMA" id="LRTMDWA"/>
    <dbReference type="OrthoDB" id="272624at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001156">
        <property type="term" value="F:TFIIIC-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039467">
        <property type="entry name" value="TFIIIB_B''_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929:SF0">
        <property type="entry name" value="TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15963">
        <property type="entry name" value="Myb_DNA-bind_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="226"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR11115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="338" mass="39277" checksum="C1DE14B4E5CC46B8" modified="2013-05-29" version="1">MEKKVLSRSILCMNKEDLKKKEEDYSKVLENKNEVVDKDHKIIVSNLNNEQSVKERKKNKKKRPASPINSEEITIEPSQIKISDLCKDIRIGRKSVKFNEIRKMEAVKKKMKLNNSELFSKKILVNGEVIPETKNVSADKNLQKTYLDTHNLGLPIVRNGNMNVTKNHLKGAPQVRVVNGKIVIDETSLQVDRRERDVNPDIEMELVEENDLSRKVNSASWGKREKSDRWSLEETQRFYNALSQWGTDFGVICKMFPNRSQRQIKNKFNSEEKKYPERINTALKSRKPIDILAYSKAVGSTFRSIDEIENELKKAKKDFEESRRISMENSKILINKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7PB80</accession>
    <name>M7PB80_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Double-strand break repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PNEG_00741</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16 18">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872642.1">
        <property type="nucleotide sequence ID" value="XM_007874451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PB80"/>
    <dbReference type="STRING" id="1069680.M7PB80"/>
    <dbReference type="GeneID" id="19894439"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00741"/>
    <dbReference type="eggNOG" id="KOG2310">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009535_3_0_1"/>
    <dbReference type="OMA" id="QNHTGHT"/>
    <dbReference type="OrthoDB" id="30417at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030437">
        <property type="term" value="P:ascospore formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010791">
        <property type="term" value="P:DNA double-strand break processing involved in repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035753">
        <property type="term" value="P:maintenance of DNA trinucleotide repeats"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010780">
        <property type="term" value="P:meiotic DNA double-strand break formation involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062176">
        <property type="term" value="P:R-loop processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000011">
        <property type="entry name" value="Double-strand break repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.110">
        <property type="entry name" value="Mre11, capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003701">
        <property type="entry name" value="Mre11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038487">
        <property type="entry name" value="Mre11_capping_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007281">
        <property type="entry name" value="Mre11_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00583">
        <property type="entry name" value="mre11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139:SF1">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04152">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000882">
        <property type="entry name" value="DSB_repair_MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01347">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 16 18" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16 18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 16 18" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 16 18" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 16 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 16 18" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 16 18" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16 18" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14 16 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mre11 DNA-binding" evidence="19">
        <location>
            <begin position="296"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000882-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMR11145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="646" mass="74746" checksum="6B94ABD63C763270" modified="2013-05-29" version="1">MNCLKNGESCTSSTIRILISTDNHVGFLEKDPIRGNDSYIAFEEVMTQARLNDVDMVILCGDLFHENKPSRKAMYQVMRTLRLNCFGEKPFELEILSDQSLMSKDVLFCHVNVEDPEINVAIPVFSIHGNHDDPSGEDRLCALDILQISGLINYFGRVPENDNIILRPILLRKGNTKLALYGLSNVRDERLYRSFKQGNVRFMRPDVEQNTWFNLIAVHQNHTSHTETGYLPENFIPDFFDLVLWGHEHECAIDPIYNPQQNFYVIQPGSSIATSLCYGEAVSKHIAILSVTERSFTLEKIRLKSVRPFVMKDISLCENKVIQPNINNKSMVTTFLMEKIQEAIEEALNEWKSFQEPYDIKEPPLPLIRLKVEYSLEYQVENPQRFSNRFVGKVANPNDVIKFYMKKNTRNKGNRILHSDVEMSNVKLENIKVEDLVKEFLNVQSLICLPEHELGEAVTRFIEKDDREALKCFVTTHLDSQVKLLTKNQVTEENLEAELIKQKQLYEERARLQHKEDENKNKITNSFESLNNKSFLGNDCHENINIEQDSVFESNNLYKNISGIVKENDFIDDKNSASGYDDIIVPNVQNIQLKVYNIDKNYSTRNLNHGKWKPQSAIYIEDDIDDSSDDEFVPRFGFKKPRLIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7PBB9</accession>
    <name>M7PBB9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GID complex catalytic subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glucose-induced degradation protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_00778</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RMD5/GID2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872681.1">
        <property type="nucleotide sequence ID" value="XM_007874490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PBB9"/>
    <dbReference type="STRING" id="1069680.M7PBB9"/>
    <dbReference type="GeneID" id="19894476"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00778"/>
    <dbReference type="eggNOG" id="KOG2817">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020227_0_0_1"/>
    <dbReference type="OMA" id="LIRECKM"/>
    <dbReference type="OrthoDB" id="1933281at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16652">
        <property type="entry name" value="dRING_Rmd5p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000143">
        <property type="entry name" value="Regulator of gluconeogenesis Rmd5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037683">
        <property type="entry name" value="Rmd5_dRing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF3">
        <property type="entry name" value="GH10162P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CTLH" evidence="10">
        <location>
            <begin position="141"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="RING-Gid-type" evidence="11">
        <location>
            <begin position="324"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="9">
        <location>
            <begin position="324"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00075398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00080744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR11185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="382" mass="44180" checksum="60614805FD7E088C" modified="2013-05-29" version="1">MEGIFKEFTFLQAKYIASSVFNTLQIIENDIQEGIKKLSDGTSENQEETLKLIKEQLRKGVTQLINGQKEIYTSLNRYGKILDKQFKTDLSSIGIHEKIPGNVEELHRLIALHWIRRAEFSLVQTFTKETCLDIPENLLHAFGHLYQILHALKNQEFDAAIKWAYSKREQLEQRSSNLEFDLHKLQFISILTRSDPNRIQVAIEYAKTHFPLFAYKHLQEIKKLMCLFCYASNISLSPYNQIYTHEHLWTSIQTSFNREYCSLVGLLPDSPLQTVSIVGSLAIPTLLKMSSIMKEKKTEWTSENELPVEVPLPSKYRFHSVFTCPVSKEQTTESNPPLMIPCGHVISKKSIERLSKDNPSNKFKCPYCPKETTPQEVILLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7PBJ1</accession>
    <name>M7PBJ1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ASTRA-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00276</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat ASA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872147.1">
        <property type="nucleotide sequence ID" value="XM_007873956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PBJ1"/>
    <dbReference type="STRING" id="1069680.M7PBJ1"/>
    <dbReference type="GeneID" id="19893974"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00276"/>
    <dbReference type="eggNOG" id="KOG0322">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041940_0_1_1"/>
    <dbReference type="OMA" id="WHKEGVY"/>
    <dbReference type="OrthoDB" id="7668193at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="11"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="346"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR11245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="361" mass="41780" checksum="C4070953AA2BC83F" modified="2013-05-29" version="1">MNNVPRPVYIFRGHEAQISYVYFFKKNENLATCDADGWVIIWNIFTFRSTIVWKAHLESILTCYDWTDTYFITHGRDNKIYVWQLEFETKKDLEVYLPVDQKKECQKKPWMLYSLNVQTLNYCSFAVCNKDKLENDIFLAVPSSIKAELIDIYDLPNCQLLYSGIGSTKEVTGIVMSLCMYYRQELLYRCLEISAGFESGHVGVFALSQDSQLWEIKHFFKIHTQPVMSIHSDPLHEFLISSGADSLVVKYSLSSNSDNNVLKFKTRHNGQQSLRIRSDAKIFATAGWDGKVRIYSCKTFSQLAVCKWHEIGCCAIAFGEVISEYHNNLELFGKSRYSERLKKHWLAAGGKDGKVSLWEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7PC65</accession>
    <name>M7PC65_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00504</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872391.1">
        <property type="nucleotide sequence ID" value="XM_007874200.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PC65"/>
    <dbReference type="STRING" id="1069680.M7PC65"/>
    <dbReference type="GeneID" id="19894202"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00504"/>
    <dbReference type="eggNOG" id="KOG3928">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_621301_0_0_1"/>
    <dbReference type="OMA" id="GLAHWMT"/>
    <dbReference type="OrthoDB" id="274828at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019368">
        <property type="entry name" value="Ribosomal_mS29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10236">
        <property type="entry name" value="DAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR11490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="441" mass="50742" checksum="0681B6528D8B3F2E" modified="2013-05-29" version="1">MNFQFHNYIFKYFQKAFLRSIHANIIVYSDKNKYQKKGIISLKKKKSFSKSNFKANVKLNESLPRIFTPLKLKLSLVDQKQSHDIGIESLNFSVIDKMDLCGGLFNFPSNILEKMKNLGVFQFERKIDHSKDPVVVLRESSVYIGRKLLDDNISSKDRRIILIGNQGTGKSFCLLQAQCLAFQKGWVVLAIPRGIDIVNNTTPFFYHEKTGLWRQPEYTSSLLDKFLKANFDILDKIFLSKEYYAGNHIVPKFTPLSRLLEIGILNLLISHDILEIFLKELNIGNCPPVLFTFDNISVICSPSQYISSEYKAIHPCDLALVKTFYTYLNGEFSFDRGAIISCTSKSFNNSDRILEVSLGFLKNRSYENIDERIISAVNGVEYYVIGNYTPIESKNILKYYLMANIVGKNIDNSISKEFIKEIMLLSGCNPRELFWNCLRMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCW6</accession>
    <name>M7PCW6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_03444</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875531.1">
        <property type="nucleotide sequence ID" value="XM_007877340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCW6"/>
    <dbReference type="STRING" id="1069680.M7PCW6"/>
    <dbReference type="GeneID" id="19897131"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03444"/>
    <dbReference type="eggNOG" id="KOG0718">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019611_0_1_1"/>
    <dbReference type="OMA" id="QLDKHTM"/>
    <dbReference type="OrthoDB" id="666364at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024586">
        <property type="entry name" value="DnaJ-like_C11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055225">
        <property type="entry name" value="DNAJC11-like_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052243">
        <property type="entry name" value="Mito_inner_membrane_organizer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11875">
        <property type="entry name" value="DnaJ-like_C11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22774">
        <property type="entry name" value="DNAJC11_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="51"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="627" mass="72526" checksum="D674A30DC817623D" modified="2013-05-29" version="1">MAQNSWETFLLSYDDVQKTYTEFQTDQFEKDDFEKELNRHKRIVEELNEDNFYALLNVSKNATELQIRESYHRLSRTLHPDKHHNPDLKAISEEKFQLIQRAYEVLMDPRKRLIYNIYGEEGLKFSWDIRKKFKTSEELLIELEKQMRKKNEQNVENMVKSRGYINLLFNISPLFQTIQTPASSRLGILSQTRKLNFFERIKYTGISAVFMKHSFSIPLSFGNNSYFNDKITFTFIGQMLSKNKTSERNIIGVMRYVYSPAIWFEVGTYLLDPKLLFSKLVCTFNKDSFMTIQTHFPTFYAPPQFIISSGKRLTPQGTGFMIFKTGCWNFWNWGLNIPFSSQRSSFTLGWQSALKPGLDNSWSAEITAGILESGISCEWVNNIGKGKNVEKVKFTASVLTSGAVFGMETSRRIGENSNAFINLSFTLPQGMIVLKVIFSRLGQKIVIPIILCTKYNLKASLWGVIVPTSILIALEAIYFKSNRIKKKKEKIAAIKKEYEECLNIKKKKAEDFLHLIYDMVHRRQCYEKQKDGLYIIKAVYGDFMTGDIIDVTIAIAALVNESQLTIHHGFSKSQIIGIWDPAFGQKKTLRVEYSFKGRVHFVEVGDKHGLIAPLREHLVTNIKKNNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCX0</accession>
    <name>M7PCX0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_03448</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875536.1">
        <property type="nucleotide sequence ID" value="XM_007877345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCX0"/>
    <dbReference type="STRING" id="1069680.M7PCX0"/>
    <dbReference type="GeneID" id="19897135"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03448"/>
    <dbReference type="eggNOG" id="KOG2684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023643_7_0_1"/>
    <dbReference type="OMA" id="IAMESEH"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099115">
        <property type="term" value="C:chromosome, subtelomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032041">
        <property type="term" value="F:histone H3K14 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141222">
        <property type="term" value="F:histone H3K4 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046969">
        <property type="term" value="F:histone H3K9 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046970">
        <property type="term" value="F:histone H4K16 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902794">
        <property type="term" value="P:siRNA-independent facultative heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF9">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="8">
        <location>
            <begin position="31"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="347" mass="39920" checksum="3A64914D9A0B7D56" modified="2013-05-29" version="1">MRASFKEKNVLDVKEYCSFIRMSNKNQSRIKLKAYNTVEDVLHLIQKSQRILVITGAGISTSLGIPDFRSDTGIYSILEKYGLSEPQEVFDIDVFREDPSIFYSFASELFPPEKFKNLFYSPTHAFIRLLQDKRKLLAQYTQNVDNIEEVVGIQKEKLVQCHGSFKNAICIICGHMVSGEIIFDNILLKTVPKCLKCLKNKKNRKKNENSCEISLGVLKPNITFFGEKLPKSFDNRIEKDIYSCDLVICIGTSLKVAPVSKIINAIPSNIPQIYISRESVKHITFDITLLSNYCDDIVANLCNRLNWDEFYDIAKLGHKYAFNRMINNAKLTWKKESESIWRLDKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7PD40</accession>
    <name>M7PD40_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor cwc15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00221</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872090.1">
        <property type="nucleotide sequence ID" value="XM_007873899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PD40"/>
    <dbReference type="STRING" id="1069680.M7PD40"/>
    <dbReference type="GeneID" id="19893919"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00221"/>
    <dbReference type="eggNOG" id="KOG3228">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068312_0_1_1"/>
    <dbReference type="OMA" id="KYREHGQ"/>
    <dbReference type="OrthoDB" id="30179at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006973">
        <property type="entry name" value="Cwf_Cwc_15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718:SF2">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04889">
        <property type="entry name" value="Cwf_Cwc_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="82"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="133"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR11795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="27171" checksum="C82982870E8BD1BC" modified="2013-05-29" version="1">MTTAHRPTYDPARGKSNEQAPTRMFSSRSLPAYTVLKYRAVGQESSEEIEQRDLRLELLEAEASHFSKKEDPYDIKRISQNNELLKNNHEDPKIKRAKILQETRNIDADDDKEDESENNEDSEDDDDEDETAELLRELEKIRRERAEENERLEREKAQKDEEQREREIAMGNPLLNISSKDFNVKRRWNDDVIFKDQARGISDRPKKEFVNDLLRTEFHRKFMKRYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7PDI0</accession>
    <name>M7PDI0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U3 small nucleolar RNA-associated protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_03001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875051.1">
        <property type="nucleotide sequence ID" value="XM_007876860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PDI0"/>
    <dbReference type="STRING" id="1069680.M7PDI0"/>
    <dbReference type="GeneID" id="19896688"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03001"/>
    <dbReference type="eggNOG" id="KOG2172">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003783_0_2_1"/>
    <dbReference type="OMA" id="QVIEPMD"/>
    <dbReference type="OrthoDB" id="277439at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006709">
        <property type="entry name" value="SSU_processome_Utp14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150:SF12">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04615">
        <property type="entry name" value="Utp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="791" mass="92148" checksum="B28994E4C30285F2" modified="2013-05-29" version="1">MLDLIKRKDQDIDRNDVLSKKNSHLFSRFETRSSKIKNVENIKFRKEKFEKLNLDKNRYNMSPDVDHNLELLTPDAEIGIVEDENTCYISEIFNNEQASFNNNGCYDNLVSEDLELNCLEEFIETLERKRKHDDFLKINEFSKKSSCETLSSHVKNNESNYFDVSEKLSFSEMIAPLNANITASSYLKSLSQSDISKFSGNSLDVPLAKSAQDFFDRQAAYDIVKKDLKKWEDVVKFNRASEFLKFPIDSLEKSKLTNNSLFAKFQASTHFERSIDDVLQSSGLKDERSVLEFEELSLNKLSVEEVAARRAELRLIRDLMFRQERKAKRISKIKSKSYRKIHRHEKKKKKSLVLGKIDYDGLPFQNEINKTKEGIDLYGFDSNKLAKQQLNNNCFVIGNKQFIKKQLQHDKRLQEKIRSICSSDSDENLDNDNKSSDINNKDLLTNLMKFRNENIKLKSSMGMQFMNSEKDKKIKNERTIDDVLNIKKDPEILCSEYSSNKVYERFSNSIGRRIFNPSFNKGYVSNINDQKPVETFKIDKSWNFISKNLSSSSYDSKILDTRFKNYNPWLIATDELSPEFYGLELKCDSEQSIIYKDSQNFKKTDETELCIDIPQGLLFPTSEIEVKNYRNNAEEDLNMIYNGSRFALKQKDLVVRAFSGDNVIENFQEEKLKNVEEHESYKKNDIMPGWGSWCGFGIKHISKKIKVSDISKKNRKDLELNNVIISEKNIKKNKKLLVSSVPYPYQTKEQYEKSLMLPLGLEWTTRGQYQKLITPRIIIKQGSVIEPLKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>M7PEJ2</accession>
    <name>M7PEJ2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM3</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_02668</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874690.1">
        <property type="nucleotide sequence ID" value="XM_007876499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PEJ2"/>
    <dbReference type="STRING" id="1069680.M7PEJ2"/>
    <dbReference type="GeneID" id="19896359"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02668"/>
    <dbReference type="eggNOG" id="KOG0479">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000995_6_0_1"/>
    <dbReference type="OMA" id="NVYPQED"/>
    <dbReference type="OrthoDB" id="1882346at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904931">
        <property type="term" value="F:MCM complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006267">
        <property type="term" value="P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17754">
        <property type="entry name" value="MCM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000008">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008046">
        <property type="entry name" value="Mcm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056575">
        <property type="entry name" value="WH_MCM3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF46">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23191">
        <property type="entry name" value="WHD_MCM3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01659">
        <property type="entry name" value="MCMPROTEIN3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="302"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="671"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="733"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="760"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="682"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR08884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="856" mass="96770" checksum="01C32DB9F31AC35F" modified="2013-05-29" version="1">MELPVLPDQLFNDRVRIWQEYLDNRLDDPNVVNYHEAIKRMLHLEERRLTVNIDDIRDYNRNLADGLLNEPSEYLPPFNKALKDVVLTIRDINKHKVDDVLFYIGLIGSFGDQHISPRTIRAQHLGKLVCLEGIVTRCSLVRPKIVKSVHYCEKTKLFHYHEYRDVTAIGNEIPTSSVYPTQDENGNPLTTEFGYSVYRDHQTISIQEMPERAPAGQLPRSIDVVMDDDLVDRVKPGDRIQLVGLYRALGNRNASSSSTFRTIIIANNVILLSSKGNGGIAQIDITDTDIRNINKLSKKKNIFELLSRSLAPSIFEYDYIKKAVLLLLLGGIEKNLDNGTHIRGDINILMVGDPSTAKSQMLRFIVNTVPLAIATTGRGSSGVGLTAAVTTDKETGERRLEAGAMVLADRGVICIDEFDKMSDIDRIAIHEVMEQQTVTIAKAGIHTSLNARCSVIAAANPVYGQYDPHKDPHRNIALPDSLLSRFDLLFVITDDIDEARDRSISEHVLRMHRYLAPGTEEGVPVADKYGKNLSVGTGSGLGADSLIYEKMNQIFYNNSSNAEKSKKNEILSISFLKKYIQYAKSRIKPVLTKKAADYIISTYSALRNDELGANQRKTSPITARTLETLIRLSTAHAKVRLSQKVEEKDAYIAEEILRYSLFKEIVKEDRRKRRRLQKTQDSESEENECEAIDENNIEPQLKSSKKIATMQHPDDDTPMPDINNIHITDYTQEPSGRNIQQESQQETQVSWGSTQSLYTQSQIDQDSLSKDNTQPNLPTEQVISPSRFSLFSSKLAHLITTPLFREEYANFNDLFSEINKELAQEELFTTREVMAALNKLSEQNKIMISNNIIYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7PG31</accession>
    <name>M7PG31_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protoporphyrinogen oxidase</fullName>
            <ecNumber evidence="4 11">1.3.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_02363</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>protoporphyrinogen IX + 3 O2 = protoporphyrin IX + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:25576"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="EC" id="1.3.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.4" evidence="4 11"/>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874368.1">
        <property type="nucleotide sequence ID" value="XM_007876177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PG31"/>
    <dbReference type="STRING" id="1069680.M7PG31"/>
    <dbReference type="GeneID" id="19896056"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02363"/>
    <dbReference type="eggNOG" id="KOG1276">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009629_1_0_1"/>
    <dbReference type="OMA" id="WFDQWFG"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF3">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="12">
        <location>
            <begin position="14"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR09419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="498" mass="56284" checksum="65DED801DFBB3CF4" modified="2013-05-29" version="1">MLSSKSIGIIGGGISGLSTAWYLSRLFSPSTKITILESSNRLGGLLNTKRIDSSHGTIYFEEGPRSLKPTGISGYITLDMIKKLGLIDEMILVPKNSPVIKNKYIYFQNQLNALPTSLLSAFISKTPIFRSFLWAIISEPFKPIRNKNISDETISSFVSRRFNTSISENLVSAFIHGIYAGDIDDLSIKSTFPHLWNYEELYGSVLKGILFNGISLNKNEENIKSTIEKDSKDIIKKTKNTYIYSFKNGLGTLSSAISKNLFTRNNVHIYFNSEVQSLEFNNIFKIKTNTSEFHFDHLISALPIQVLTKLLDPFKKLTRSFSSTTILVVNLFFDNPNLLPFQAFGYLIPRSVSKEENPEQALGVIFDSNSFPELDTYKGTKMTVMIGGSFWKHKAIFPKESEFIKLARNVILRHLRIKDTPVIVNYKLQKNSIPQYNLGHHQDLKNIHNYVYNTYKGNLSLVGNFYGGIGVNDCIKNAYLLTRRLKEKGKATGLESIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7PG71</accession>
    <name>M7PG71_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Karyogamy protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874407.1">
        <property type="nucleotide sequence ID" value="XM_007876216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PG71"/>
    <dbReference type="STRING" id="1069680.M7PG71"/>
    <dbReference type="GeneID" id="19896095"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02402"/>
    <dbReference type="eggNOG" id="ENOG502QUB2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_413383_0_0_1"/>
    <dbReference type="OrthoDB" id="5559380at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051293">
        <property type="term" value="P:establishment of spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013889">
        <property type="entry name" value="Karyogamy_KAR9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37271">
        <property type="entry name" value="KARYOGAMY PROTEIN KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37271:SF1">
        <property type="entry name" value="KARYOGAMY PROTEIN KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08580">
        <property type="entry name" value="KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="664" mass="77726" checksum="EFF84A2171D380FC" modified="2013-05-29" version="1">MDKSSNYFEEIDKIKDKKEDNEGFSYLNKLMGREFIDFLQSSSFEQQLSQLRSLLFIPRMKLFEKEDIEVKEEYFYVFTDVSVYMLSWIELVIYIFKYFDLEDDIEWANQAKGLFNELEQEIRNSSPVFDKFIEETSSPVLENLTDFDILNLNTKRQEVYQGWIFIKKLLGFIKSQIEISKEWVDCIEILNQINQELKKCEVLVFEVKERCDYIPFISGRFVEISTLESFVKDIFDGEKVGGLEQINSTDMLNKWNMNCQNFICQVHEKVKPLETSLIFFKLRIEYFKEKASELFPSAIYNIEQKRLNLEIKCNKLQDEFFSVKKKFQEDKWLFVFSQVNKQATQIMDSLEMEIKKFNVLSPLTKKASEFYKTYKVKKDSYVIIRIITLMEWGIWNKLTCNSRVIEGYNALYERWKNLNKDIIKIDNIILEDDSTSEIIEDNAQSVSHDSESEASQSTRSCIMTPKTPKTPKYIAKQYSLIPVSKTSRRSSLSSTLKTGSKNYSTPRILCHSSVPSKGSKISSFIEETPLRFPRFKLFSSIMEKTEASSALASQLIPKSTPVKNSSYSGTKTKDFESNIPRSCDSIRRMVSTGGILHKTSDMKFMKYKENISFSNIPRPSFRRMTCLPILENKDSMRMIPSQKTFMTRTSIPLIRKRECIFGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7PGG2</accession>
    <name>M7PGG2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PNEG_02129</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AdoMet synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874111.1">
        <property type="nucleotide sequence ID" value="XM_007875920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PGG2"/>
    <dbReference type="STRING" id="1069680.M7PGG2"/>
    <dbReference type="GeneID" id="19895822"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02129"/>
    <dbReference type="eggNOG" id="KOG1506">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041802_0_1_1"/>
    <dbReference type="OMA" id="ASYMARY"/>
    <dbReference type="OrthoDB" id="5852090at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000001">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="13">
        <location>
            <begin position="4"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="14">
        <location>
            <begin position="116"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="15">
        <location>
            <begin position="238"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMR09544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="381" mass="42303" checksum="CFA74C97650ED99B" modified="2013-05-29" version="1">MSRFLFTSESVGEGHPDKICDQVSDAILDACLKEDPNSRVACETAIKTEMVIIFGEITTKAVLDYKKIVRETIKRIGYDGLDKGFDYRTCNIFVAIEEQSPDIAQGLHLEKSLEHIGAGDQGIMFGYATNETKELLPLTILLAHRLNMALAEARHSGEIKWLRPDSKTQVTVEYEQENGMVVPVRVDTVVISTQHADIISTEKIREEILEKIVKKVIPSEYLDEKTVYHIQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFSKVDRSATYAARWVAKSLVASGLCKRCLVQLSYAIGISYPLSIYVEHYGTSKKTSSELVEIVKKNFDLRPGVIVKELGLQLPIYSKTACYGHFTDQSFSWEKPKKLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>M7PI07</accession>
    <name>M7PI07_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P-type Na(+) transporter</fullName>
            <ecNumber evidence="19">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PNEG_01378</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="19"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873312.1">
        <property type="nucleotide sequence ID" value="XM_007875121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PI07"/>
    <dbReference type="STRING" id="1069680.M7PI07"/>
    <dbReference type="GeneID" id="19895075"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01378"/>
    <dbReference type="eggNOG" id="KOG0202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_3_0_1"/>
    <dbReference type="OMA" id="NGQEYSM"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000016">
        <property type="entry name" value="Calcium-transporting P-type ATPase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000058">
        <property type="entry name" value="Probable ENA2-Plasma membrane P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000015">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000039">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000047">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="778"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="815"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="856"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="903"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="954"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="987"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="23">
        <location>
            <begin position="19"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EMR10098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1049" mass="116896" checksum="05CC93B613A17147" modified="2013-05-29" version="1">MYYKNKSKNHVEVFQYPKHPFLLSPRYIEEVLSTSMENGLNSEEAEKRLLKYGANSLNNEGGVSVIAVLLRQAANAMTLVLITAMIVSLGIRDWIEGGVITAVILINIVVGFFQEYNAEKTVSSLRSLSSPTAHVVRDGSSFTIPSSRIVPGDVVELKTGDTVPADIRLFEAMNFETDESLFTGESLPVSKSVTMEFTDEDIPIGDRVTMAWSVTSVTKGRAKGIVVFTGMATEIGTIAKSIQKKKIIKRNEEGKTSPHAYIIACGMVILDGIGRFLGINIGTPLQKKLSALAIGLFGIASLFALIVFAANRFVTKDEVVLYAIATGLSMIPSSLVVVLTITMAVGTKRMVHRHVIVRKLDSLEALGAITDICSDKTGTLTQGKMIARQAWICGFGMFLVSENNEPLNPTAGTVVFVNATPLEYIQDNYREKVEINLETFNISQELDGFLNVASLANLSTIHQDNEQRWKATGEPTEIALQVFASRFNRGKNKLSKGFNSLWTQLAEFPFDSDIKKMSVVFQKNTEKKIMVFMKGAIEKVIHDCITMGAEMKPLSEKDKEEVFRNMEVFTSQGLRVLALAQRQLIENIDNWDEVSRDDIESNMNLLGFVGIYDPPRPESASSVKECHQAGINVHMLTGDHLGTAKAIAMEIGILPRNMSKFSNSISYMIMTASEFDKMSDSEIDSLSCLPLVIARCAPRTKVRMIEALHRRKAFCAMTGDGVNDSPSLKHADVGIAMGMSGSDVAKNASDIVLIDDNFASIINAIEEGRRMFDNIKKFVLHLLAANVAQALYLLIGLVFQDKSGFSVFALTPVEILWIIMVTSAFPAMGLGMEAACSDIMKRPPHNIKIGVFTYEVIVDTFVYGFIQAVICLVSYVIVVWGYGDGNLGVFCNDFYNSSCEQVYRGRSTTFVELTWMILILAWEVIDLRRSMFYSNPESPFKYTQLYHHLKGNKLLLWSVVFGFFSVFPVIYIPVINKEIFKHSPITWEWILALSGLLLFIITSELWKWAKRIYYRHCQKRAYNFDSDLEKKCPFERYASIENNTIKLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7PI75</accession>
    <name>M7PI75_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear pore complex protein Nup85</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_01438</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the nucleoporin Nup85 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873378.1">
        <property type="nucleotide sequence ID" value="XM_007875187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PI75"/>
    <dbReference type="STRING" id="1069680.M7PI75"/>
    <dbReference type="GeneID" id="19895135"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01438"/>
    <dbReference type="eggNOG" id="KOG2271">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023369_0_0_1"/>
    <dbReference type="OMA" id="ELMEWLN"/>
    <dbReference type="OrthoDB" id="17644at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011502">
        <property type="entry name" value="Nucleoporin_Nup85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373">
        <property type="entry name" value="FROUNT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373:SF21">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07575">
        <property type="entry name" value="Nucleopor_Nup85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7 9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR10164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="716" mass="82599" checksum="E26A16D8DF864D0A" modified="2013-05-29" version="1">MDFQDTSYDEQEEVLDLTYIAPDAPIESGKLKEWRDRRRTLKVVIHPLLNMAISWISIIDIYKNPKEKQDYVFSPEESALYTVHTPIFFLNSCQVRLSNVMSSYFEELQMLYENLEYKFFDPKEMLLGSSQSLIPSFFNRICKSYRIATEDAINEYKNDDEMDQDILMTLVDSYTLLYCVEAIYLNSDDRNYSELIVEWVNRSDPQPSQQDGLEIMTSRTPCLHPGFWSYVHKAALRGLFKQVISCLQQSGIESVEPKAVEVIDTTIDILETFQSYRKSFGNENILKWRHWRGRVISCIRTLKLDNLEISSAFRCLFEIISGDRDAIFRESDTWQECLGALILLNDPLNCKTVKDIYRVYDSVVKGEDSFTVDETLPVESACAALFSGNIPKAMIQAAQIQSGIAAHISDLLLKAGILEEFETNEYPLSLRDYLVLNYADQLITNPDTWKIALVYWKTVSEIGIQRIKTVLPRIPLTSDERTEEVLAFCDQFHLHEEACMIASIWAKELERKKKLGSAVLLYDRVNNAYQIDQINWILFETSLIQGYPANVDQLMETFLESPYSSSSRSIASLLAPYAILNSFYQLKFEGKRCAAAHYLASLIKAVDIPKKYMLLLLAEMLSFLDDSLPRAFTMRDIFDCIAAIEEFQSLIFKEDCIKLFNKAKSYNSYLQNSQSSQNSDNWRHKINQNINENNILELVRLQITKTIARGFLEPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJM3</accession>
    <name>M7PJM3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="12">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PNEG_01358</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="12"/>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873288.1">
        <property type="nucleotide sequence ID" value="XM_007875097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJM3"/>
    <dbReference type="STRING" id="1069680.M7PJM3"/>
    <dbReference type="GeneID" id="19895055"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01358"/>
    <dbReference type="eggNOG" id="KOG0345">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_26_4_1"/>
    <dbReference type="OMA" id="AYKEHEC"/>
    <dbReference type="OrthoDB" id="7396459at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17960">
        <property type="entry name" value="DEADc_DDX55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="40"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="266"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="550"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="553"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMR10659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="574" mass="66343" checksum="B249360D3A43864A" modified="2013-05-29" version="1">MPDFSSLLWDDMEISLTSWIRNAINEMGFEKMTPVQASTIPFFIKNRDVVVEAVTGSGKTLAFLLPILEKLIRRDEPLTEFHIGSLVVSPTRELAMQIYSVYQTIMKKSEQMNTNLRAQLVIGGTMTIQHNIDEFNEISPSIIIGTPGRINQLLSLSLVKTKELEILVMDEADRLLDMGFFPVMESIIKKLPKQRRTGLFSATMTEAVDKLIKTGLRNPIKIVVRVGNQENTKEDRCVPASLQILYMVLPSAEKFIQLIRLLNYSYIKDGMKKFIVYFLSCICVDYFFLIFSQISYLKKTFRIFSLHGKQSSSLRTKNYKAFFNALSETPSILFTTDLAARGLDVPNVDMVIQMDPPLDPKSFCHRCGRAGRAGRPGKAVVMLNRGREEDYVHFLKVRKVPIQPLERIGKHNNIMENKEDESKEDILALVKEIRDIVKKDRDLYEKGLKAFVSYIRAYSKHQAHFIFRVKDLDFSGIAYSFGLLHFPKMPELKNMVLDFEEENIDLDKLTYADKLKEKARLKKKKEQELMNEKKNSVFIKKKTIPWSKNIELKKKKKNRQSKRKHKSFKEKNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7PL39</accession>
    <name>M7PL39_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00782</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872685.1">
        <property type="nucleotide sequence ID" value="XM_007874494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PL39"/>
    <dbReference type="STRING" id="1069680.M7PL39"/>
    <dbReference type="GeneID" id="19894480"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00782"/>
    <dbReference type="eggNOG" id="KOG1188">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PLGCEYV"/>
    <dbReference type="OrthoDB" id="25131at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039328">
        <property type="entry name" value="WDR89"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR11189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="356" mass="40444" checksum="B5964C44844BE20D" modified="2013-05-29" version="1">MKEFHPFYIAKYPDDSIYVYNLGIADNILVSAASDNTLRLWDRETLKTYKVIHEVHDHISDMKISGNHSILTCGEEGTAKIWDTRTLALCGQFKPGFKINIYKLSLNVLAKKMPLLCISENIEKTMIAAGSALLGSDAYLFLWDQRKQSLLFSYKESQNDDITDVRFDSIQSHRLCAGGCDGLINIFDTRFSIEDDAIINVFNNQSSIHRADFLGPNKVLGLSHMETLSLYNINDISRNNTDNIIDSTYISLGDLRSKLNCNYVIDIILNITKNTAYICCGSHTGKIRLFEFHQDATINKDEQILLQGHDDSIARSLVFDQQMQIIYTGSENGEIRANRYETLQQTPPTKKIKLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M7PLL1</accession>
    <name>M7PLL1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872236.1">
        <property type="nucleotide sequence ID" value="XM_007874045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PLL1"/>
    <dbReference type="GeneID" id="19894061"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00363"/>
    <dbReference type="eggNOG" id="ENOG502T172">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2428329_0_0_1"/>
    <dbReference type="OrthoDB" id="70763at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034719">
        <property type="term" value="C:SMN-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020338">
        <property type="entry name" value="SMN_gemin7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14679">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14679:SF1">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11095">
        <property type="entry name" value="Gemin7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="102" mass="12055" checksum="B0B744A9F18E0323" modified="2013-05-29" version="1">MIDSKSSYQIYENNSQEIAFLQRMRTLKFYKFVSRSYKPVTFYLWNKAHLKASSFLGTDALETKFLVENLQTDWGIHKQAVIRSGDIIWIKFPLELLEEGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7PMX3</accession>
    <name>M7PMX3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00225</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872094.1">
        <property type="nucleotide sequence ID" value="XM_007873903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PMX3"/>
    <dbReference type="STRING" id="1069680.M7PMX3"/>
    <dbReference type="GeneID" id="19893923"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00225"/>
    <dbReference type="eggNOG" id="KOG3259">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090028_0_0_1"/>
    <dbReference type="OMA" id="DEVQCLH"/>
    <dbReference type="OrthoDB" id="2530521at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140463">
        <property type="term" value="F:chromatin-protein adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000026">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051370">
        <property type="entry name" value="PPIase_Pin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657:SF4">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="7">
        <location>
            <begin position="66"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR11799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="177" mass="20285" checksum="34DF1DD878EF55F9" modified="2013-05-29" version="1">MIQVNGLPEDWEIRCSRSRNLPYYYNMKTHESFWEPPSDADLEVLKDYMIKNGLIPVSSEENKVNDEKIRVIHLLVKHNHSRRPSSWKEPNITRTKQEAMEIILKYEAKVRSGEISLGELAVTESDCNSAKKAGDLGFFGKGVMQREFEEASFSLQPGEMSHVVETASGYHLIERIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWV6</accession>
    <name>A0A0W4ZWV6_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_04347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="KTW32846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613327.1">
        <property type="nucleotide sequence ID" value="XM_019757857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWV6"/>
    <dbReference type="GeneID" id="30671616"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04347"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KTW32846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="74" mass="9148" checksum="1974454BFC5F6645" modified="2016-03-16" version="1">MFSKKSIIIIATRIKKKKRLKIWRDSKEKKIYKFKKIQKIIKKFKLHLSYCYSTFDKLNHNRKKIGFIFWIGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZX23</accession>
    <name>A0A0W4ZX23_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">60S acidic ribosomal protein P2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_04274</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 33 different proteins. The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and at least 46 different proteins. The acidic ribosomal P-proteins form the stalk structure of the 60S subunit. They are organized as a pentameric complex in which uL10/P0 interacts with 2 heterodimers of P1 and P2 proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="KTW32921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613391.1">
        <property type="nucleotide sequence ID" value="XM_019757796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZX23"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZX23"/>
    <dbReference type="GeneID" id="30671567"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04274"/>
    <dbReference type="OMA" id="MKVIASY"/>
    <dbReference type="OrthoDB" id="1227494at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="71"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KTW32921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="11504" checksum="E5B8A9183FD57F7A" modified="2016-03-16" version="1">MKHLAAYLLLELGGNKKPTSEDIKKVLGSVGLEAEEKRLKSLLNQLENQSIEELIASGKEKLASLSSVAVGSASKNVQETAAKVEEPVKEEEKEESDEDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZX28</accession>
    <name>A0A0W4ZX28_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_04265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="KTW32928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613397.1">
        <property type="nucleotide sequence ID" value="XM_019757788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZX28"/>
    <dbReference type="GeneID" id="30671560"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04265"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KTW32928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="73" mass="8701" checksum="C20CE54F253FBF65" modified="2016-03-16" version="1">MGKQKNSKKKYDPITKLLYWLLANQPADLPFILCKLIIIANSNNEYFKVHPLVLRILEKFRLIKFYHQILSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M1FRL7</accession>
    <name>M1FRL7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 17">Cytochrome b</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">cob</name>
    </gene>
    <organism>
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="20"/>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2013" name="FASEB J." volume="27" first="1962" last="1972">
            <title>Sequencing and characterization of the complete mitochondrial genomes of three Pneumocystis species provide new insights into divergence between human and rodent Pneumocystis.</title>
            <authorList>
                <person name="Ma L"/>
                <person name="Huang DW"/>
                <person name="Cuomo CA"/>
                <person name="Sykes S"/>
                <person name="Fantoni G"/>
                <person name="Das B"/>
                <person name="Sherman BT"/>
                <person name="Yang J"/>
                <person name="Huber C"/>
                <person name="Xia Y"/>
                <person name="Davey E"/>
                <person name="Kutty G"/>
                <person name="Bishop L"/>
                <person name="Sassi M"/>
                <person name="Lempicki RA Kovacs.JA."/>
            </authorList>
            <dbReference type="PubMed" id="23392351"/>
            <dbReference type="DOI" id="10.1096/fj.12-224444"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="17">Binds 2 heme groups non-covalently.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="16">Binds 2 heme groups non-covalently.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14 17">Belongs to the cytochrome b family.</text>
    </comment>
    <dbReference type="EMBL" id="JX499144">
        <property type="protein sequence ID" value="AFR90415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_007475005.1">
        <property type="nucleotide sequence ID" value="NC_020332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M1FRL7"/>
    <dbReference type="STRING" id="1069680.M1FRL7"/>
    <dbReference type="GeneID" id="14657954"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00290">
        <property type="entry name" value="cytochrome_b_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00284">
        <property type="entry name" value="Cytochrome_b_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.810.10:FF:000002">
        <property type="entry name" value="Cytochrome b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="entry name" value="Cytochrome Bc1 Complex, Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005798">
        <property type="entry name" value="Cyt_b/b6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036150">
        <property type="entry name" value="Cyt_b/b6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030689">
        <property type="entry name" value="Cytochrome_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048260">
        <property type="entry name" value="Cytochrome_b_C_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048259">
        <property type="entry name" value="Cytochrome_b_N_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19271">
        <property type="entry name" value="CYTOCHROME B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19271:SF16">
        <property type="entry name" value="CYTOCHROME B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00032">
        <property type="entry name" value="Cytochrom_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00033">
        <property type="entry name" value="Cytochrome_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038885">
        <property type="entry name" value="COB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81648">
        <property type="entry name" value="a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="Transmembrane di-heme cytochromes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51003">
        <property type="entry name" value="CYTB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51002">
        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 16 17" id="KW-0349">Heme</keyword>
    <keyword evidence="11 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17 20" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b/b6 N-terminal region profile" evidence="18">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b/b6 C-terminal region profile" evidence="19">
        <location>
            <begin position="211"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <label>b562</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <label>b566</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <label>b562</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <label>b566</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR038885-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR038885-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AFR90415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="384" mass="43950" checksum="499F7270807054E9" modified="2013-05-01" version="1">MRIIKVHPFLSIFNSYMIDSPQPTNLSYLWNYGSLLGVCLTIQIVTGITLAMHYIPSIDLAFLSVEHIMRDVNYGWLIRYLHSNTASFFFLFVYLHIARGIYYGSYRHPRTMVWSIGVLIFLLMIITAFLGYVLPFGQMSLWGATVITNLLSAIPWIGSDLVNFIWGGFSVNHATLNRFFSLHYLLPFLLAGLVIAHLIALHEHGSGNPLGITGNVDRIPFHPYYSFKDLVTVFLFFIALSYFVFYNPNVLGHSDNYIMANPMSTPPSIVPEWYLLPFYAILRSISDKLLGVVAMLASILILWLLPVLDLSRIRGSVFRPISKFLFWIFVTNFLLLMYLGSQHVEEPYITIGKYATIFYFSYFIFIIPVIAIIENTLSDLALEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M7NIE2</accession>
    <name>M7NIE2_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875236.1">
        <property type="nucleotide sequence ID" value="XM_007877045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NIE2"/>
    <dbReference type="STRING" id="1069680.M7NIE2"/>
    <dbReference type="GeneID" id="19896860"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03173"/>
    <dbReference type="eggNOG" id="KOG3566">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007442_3_1_1"/>
    <dbReference type="OMA" id="MAIALWM"/>
    <dbReference type="OrthoDB" id="445301at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007246">
        <property type="entry name" value="Gaa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304:SF0">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04114">
        <property type="entry name" value="Gaa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036762">
        <property type="entry name" value="GAA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="498"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="541"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="570"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="630" mass="73294" checksum="CFEA65578266A2DE" modified="2013-05-29" version="1">MINLYNFLFLFRICCFIVGFMWIFMLPLNYFNRHVFISENAILPGTVNTYFGDSDSDSDIIEAYREEINFIDQQGEDAKYESLHEIFERLGLRTATQDYKVEFKGKEYSGRNFFAVLDAQRGDGTEALVLSASWKNMDGKLNLGGVSLLLALARYFKRWSLWSKDIIFLIPGEKEVGAQLWVDAYHKMDYDDAILSLTLKSGEIQALVDIDFISDYRNFDSIELLYDGMNGQLSNMDLLVAVNRIIQSKSDVKINMQNVLQQKETYFQKLLTMINGMINQCFGFLSGTQSCFVPYKIDSITFKVKSKGSGIYDDILLGKIIESSFRSLNNLLEHFHQSFFFYFMLSVDRFVSISAYFPSAILIASSFTIDSLSLWISVIANLNKSLSVYEKEKFNNSNDEKKKVFIERDPRLRLRKEIALSIATVIVVYIIAIIFLKIIYNSCYYKESSDYKKFYSIFILFLQILQHIISIFIQRILEKIIKSQNMSLINNYKLIRTFSQIILGIELSTLAIVNFSLSFFVGIITFPLSFVRPARTKTERILFSVLLELSNPLNWIFFLSYYKNKEAIDFIYLFVFGWKIWYLWTPLVLWLLWWPLWIVAKITISTSINDNAGHYFYNTPKSIDPLLKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7NIH5</accession>
    <name>M7NIH5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DNA repair protein rhp54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_03218</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875281.1">
        <property type="nucleotide sequence ID" value="XM_007877090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NIH5"/>
    <dbReference type="STRING" id="1069680.M7NIH5"/>
    <dbReference type="GeneID" id="19896905"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03218"/>
    <dbReference type="eggNOG" id="KOG0390">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_10_2_1"/>
    <dbReference type="OMA" id="YTEHERM"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032392">
        <property type="term" value="P:DNA geometric change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030491">
        <property type="term" value="P:heteroduplex formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000010">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000332">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013967">
        <property type="entry name" value="Rad54_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08658">
        <property type="entry name" value="Rad54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="215"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="548"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR08378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="786" mass="90564" checksum="22BE346C5E38E0F9" modified="2013-05-29" version="1">MFRSLAPSHRKQKNLIEKNEVNYENNERGPLIEIGNGLSKAFKVPSYKKNPGLEEGRLRKKLKIYNEIREEEKEKKLFRKNSLVQIRDAREVLKQKFIIPMKDKEKENKYDKNRVPPTLGTLRPVKLIPKPLYDPHGEFSIVLYDPTIDSFLKEEDEVEIHKSISKIHKPLAEILGIKKEKNYTNVAVVIDPKLSKMLRPHQIEGVKFLYKCVTGIIDPRANGCIMADEMGLGKTLQCITLMWTLLKQSPQAKHSTIEKAIIVCPSSLVKNWENELDKWLGKGTINSLSIGKKTTREQLSTSLSKWASATGKDIVQPILIISYETLRMNIDQLKKCKIGLLLCDEGHRLKNSESLTFSALDSLKVQRRIILSGTPIQNDLSEYFSLINFVNPGLLGSRNEFRKTYELPILKGRDALGTDKDREIGDQKLEELSVLVNKFIIRRTNDLLSKYLPVKYEHVVFCNLSPFQKKLYQNFISSCEINNLIKGIESQPLKAIDFLKKLCNHPSLLDLKEDLKGFEHCFPSDFFSKNARGRNNDIKIEYSGKMMLLDRMLAKIRKDTNDKIVLISNYTQTLNLLEKLCRFRRYGTLRLDGTMSTNKRQKLVDKFNDPEGEEFVFLLSSKAGGCGLNLIGANRLILFDPDWNPAADQQALARVWRDGQKKDCFVYRFITTGTIEEKIFQRQSHKQSLSSCVVDDAQNVERHFSLDNLRQLFELNLNTLSDTHDTFKCKRCKDNKQFIKAPALLYGDTSTWNHFSKASLEKINDFLLRQEINNDVLSFVFQYISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7NIS6</accession>
    <name>M7NIS6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_03328</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875405.1">
        <property type="nucleotide sequence ID" value="XM_007877214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NIS6"/>
    <dbReference type="STRING" id="1069680.M7NIS6"/>
    <dbReference type="GeneID" id="19897015"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03328"/>
    <dbReference type="eggNOG" id="KOG0922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_5_11_1"/>
    <dbReference type="OMA" id="FHEVMET"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000578">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000145">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049945">
        <property type="entry name" value="AAA_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF136">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX35-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="49"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="236"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="618" mass="69331" checksum="5B6625713781FAF1" modified="2013-05-29" version="1">MTFGGSALDKASENEIDEGDIPIINKLTSLSIKRQRELLPIYHHKNILLYLIEKTPVTIIVGETGSGKTTQLPQYLKEAGWADNGNVIACTQPRRISAATVAIRVAEEVGCPLGDEVGYSIRFEDVTSEKTKIKYMTDGMLVRETLIDPLLSHYSVIMLDEVHERSLYTDILLGILKKIQKRRKTLKIIISSATLNADELLSYFNKENNDTAKIISIEGRMYPVDILYLSEPTSNYIEKSVETIFEINSKEKDGDILVFLTGKEEIDICISKIIEQSDRLLSNNNRRILALPLYSGLSSERQIEIFAPAPQGTRKVIISTNISETGVTIDGIVYVIDSGFVKLRVFNTHTNFESLIIAPISKTSAFQRAGRAGRTRPGKCFRLYDNSSFLALKETNIPEIQRSDLTGLILQLKALGIDNIARFDYITNPPSEMVIQSLELLFSLGSLDEYGKLTSPLGMRMAEFPINPKMAKMLLMSNKFSCGEQILTIAAMISVQNVFLPQENKKSFEAARKKFSVEEGDHITLMNIFHAFTTKGEKSSKWCHEHFLNFKALSRAVSIRAQLRRYLERFKIPIKSADPKSGTDNIRKCLVSGYFSHAAKMQTDGSFRLVKGNAVIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJ29</accession>
    <name>M7NJ29_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_03100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875155.1">
        <property type="nucleotide sequence ID" value="XM_007876964.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NJ29"/>
    <dbReference type="GeneID" id="19896787"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03100"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_17_2_1"/>
    <dbReference type="OMA" id="TFWACLT"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000604">
        <property type="entry name" value="ABC transporter B family member 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001471">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF15">
        <property type="entry name" value="ALPHA-FACTOR-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="736"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="778"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="857"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="884"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="961"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="997"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="48"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="377"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="737"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="1058"/>
            <end position="1293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR08623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1297" mass="148394" checksum="31583DF2A3818673" modified="2013-05-29" version="1">MKKVQTSDLEKNSASFINSAQNYRNAIKNASFLNIFAFLKKKDAFLLLFACIISIINGFFKPYMTFLLGRLFHAFSLISLKEITEKQFKSQIDQYILHLLVLAIASFIGGWLFQSLWHIFAEIYIKRVYKKLFSSFASKEFEWYDSNRTGISGLINRCEKDIQSLHYTHSNVLGRLLSSFITLVISLFLAFWYSWKLTFAILVSLPVVILIAAITSYFIGPYIYREKEILTRAATHVNQAIVNMPIVKIFNAQQYESRNFDSYISKSSNFIRLYKKTYSIQQSIIRFFVLVMFIQGFWYGTHLVITNEVSSGNVLTVFWACLMISFSMQTIIQLLLYLKSGIIASYDLQNIFKDEKNKKSPYSFQGSLFPEKCHGKIVYDLVSFAYPLRPEKIILKDVSLVFPAGKTTFIVGSSGSGKSTLAALLIKIYKPDSGSIYIDNKHIGLLNTNWVRNNVTLIEQPVIFNETLKLNITLGKPSPDLTDISEIKNASRMALLEEMIYELPDGYDTRLGMNGMLLSNGQMQRVAIARARFRDTPILILDESTSSLDYINRSLIYDAIRFWRKNKTTIIITHDMSQIKGSDYIYVMNDGFLVQKGFKNDLLEDKNGTFFNVYSQKKGDKIDAISPERIHSSPGNISKNMSIESFSNDKPQMDQAVYESLKTKLNKEEIFLLNSGNITLRNRRNTTNIRNLLASNINNYKSKKEYGFLKKYFRLNISLWNILKNNWSYINKKTYFIIGLLFCIGNGISTPLFSYTLSKLLALFFSSKSILEIKRKSLQYSMIILGVSFFDSLTLYLKIYLLEYSADSWITNIRSILFKNILFQDIHYFSEGTYSSENTTRIIINETELMRTIFGQITGNILVAVVMVLAGVIWSFVIAWKLSIIIVGVAPLLYISIRLNSYLNTKWDHKYKDENINAMSILYEFSGNIFTVKALLLDNFFQKKFMLSIKRIFVKGIRKAIYIGFGYGIMESIIFSFEALLFFYGSRSILNKTYTPIVVLTIFSLIIFSVITAAQFLSMVPQYNKVKKAYESVNDLFNISEKNTENKGSLIVPLNGEIIFKNIFFSYPGHSDIQVLENINLKIENNEKIALVGLSGSGKSTMISLIQKLYQAHSGFITINGHNISSIETKWLRNHIAVVRQTPMLFNRTIEQNIAYGLDSFNISDVRKAAQKAAIDDFIIKLPDGYNTILGDYGRGLSTGQAQRVSLARAFIRNPRILILDECTSSLDSLCASSIQEIIKNITNMTVIIVTHSKEMMKLADKIVLLKSGRIAETGTYDELIKMKKDFWTLIQKGQWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLA0</accession>
    <name>M7NLA0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="12">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PNEG_02385</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="12"/>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874391.1">
        <property type="nucleotide sequence ID" value="XM_007876200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLA0"/>
    <dbReference type="STRING" id="1069680.M7NLA0"/>
    <dbReference type="GeneID" id="19896078"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02385"/>
    <dbReference type="eggNOG" id="KOG0351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_269610_0_0_1"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001975">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000296">
        <property type="entry name" value="ATP-dependent DNA helicase RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="534"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="738"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="14">
        <location>
            <begin position="1123"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMR09443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1212" mass="139923" checksum="235A3008B3783F0D" modified="2013-05-29" version="1">MGFQKVKNNIDIYLKWFYKEKPHIPSQGIRKKIVDNMKFCKSDENIKTQTLYGCQRVIPEPELSNQSFPVKIDQGSETDPSSDMKYCLELLSDFENLNENSFISNINQKSSEDSQSNIFIDLTRFDDKNKKLDDYSKRKVDFIHVYDRKRCKSSNNFEKMRFEVLDDNYKSDGHNDPEILIADSQKMNIGSDKPLKEYSHVVLDSEFSSDSLIDDFELTQIDIPKDESLVSLTYNDLLFLLDTQEKLNLAHKNEKDVLERLLKVASDSPASLKNKSTLLEERKEIKHRILELENIIEQKKTRKVFNVNDEMQKRLEKLDNHLSYSLSLKDEKSLNLSKKTANGNLEASICKFQECDLFSRDNDNFDKSACLFADSLGNKQNPVKSPVILDNFCDSLSSDIIYNTDADDFDEFHDSQCDIFHENNFDKNTETNSVFNSNNQELFQKTSSNFVSDFSSDGFVTSRQHDTVFSKESHSVQNKVSLNQTSTLKKSVLTANMPLVSGYNISYPWSKDVFMILKNVFGLKEFRSNQLEAINTTLSGRDLFLLMPTGGGKSLCYQLPSLIDSGKTKGLTLVISPLISLMQDQVEHLLSININSELINGETPVSKRKEVMKILYSNNMSLKLLYVTPEFLVRNNSFGKVLDHIYSKNNFARVVVDEAHCISQWGHDFRPDYKQLGQIKQKYHNVPFIALTATANEIVKKDVIHNLNINNCVVLSQSFNRPNIYYNVAFRDTSVYSQVRDIIMSNYAGKSGIIYCFSRKNCEDTARKLREKYQMKIHHYHAGMTNKERSQVQRDWKGGKYHIIVATIAFGMGIDKSDVRFVIHLFLPKSLEGYYQETGRAGRDGNIAQCWLFYSYKDKTKLERMIDKGYANWSQKNRQKASLHLVLQFCENKVDCRRKQLLAYFNEKFSEKECNQTCDNCREGSFVVKKDMFHMGKEIVKIVLAVQENKFTALQCINIFRGIKNNKVVNFGYEALPSFGSGSSLSRLDAERLFHVLISYDIIKEVSDITEMGFVVTYVKVGRNGMSFLKGNESLFMSFKPNSNSDLSNKTFSQKQETIELLSNMSSVRQLKMNRKKTYKKSSKIVPICNVKKNRFENFKAKIDTSPKHFLNKMSLNLNPYELDVLERCYQEMCQLRDNTANEQGISPASILSDKELLDIATKLLKNLDPIALKSDDKTFHARFEKWGYYFIDILDKYIKEKEENLRDIEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLE3</accession>
    <name>M7NLE3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_03459</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SRR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875549.1">
        <property type="nucleotide sequence ID" value="XM_007877358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLE3"/>
    <dbReference type="GeneID" id="19897146"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03459"/>
    <dbReference type="eggNOG" id="KOG3131">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062516_3_1_1"/>
    <dbReference type="OMA" id="HWFPLHK"/>
    <dbReference type="OrthoDB" id="551431at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040044">
        <property type="entry name" value="SRR1L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626:SF3">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="163" mass="19046" checksum="EAB4341603C78C68" modified="2013-05-29" version="1">MLGLGSFQNNSRSLTQLCFGIEISKNLGFKGKLEAYDPVFTFLDCQFLKELNIDFDLENSSDLYDAKQPVIFYMPHCPISMYETLFKKNWTLKRLCNIFLIGNSLKTYDLTMELAKKKKYPFVFKACLIFESILFSKAFEQPETFNDLAFQWCEEIVAEKFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLW4</accession>
    <name>M7NLW4_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Queuine tRNA-ribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_03569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875661.1">
        <property type="nucleotide sequence ID" value="XM_007877470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLW4"/>
    <dbReference type="STRING" id="1069680.M7NLW4"/>
    <dbReference type="GeneID" id="19897256"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03569"/>
    <dbReference type="eggNOG" id="KOG3908">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022060_1_0_1"/>
    <dbReference type="OMA" id="IDLFDCV"/>
    <dbReference type="OrthoDB" id="10249838at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:tRNA-guanosine(34) queuine transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002099">
        <property type="term" value="P:tRNA wobble guanine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="296" mass="33605" checksum="CC404422552B73FD" modified="2013-05-29" version="1">MISLLKLSRVTEEGVEFHSPYDGSLMLLTPEHSISLQNSIGSDIMMQLDDVVHSLAPLERIEEAMWRSIRWLDRCIAANKNPEKQSLYAIIQGGLNEKLRTICCLEMIKRETPGIAIGGLSGGEEKSKTFKIVSVCTDLLPSNKPRYLMGVGYTEDIVVSVALGIDQFDCVYPTRTARFGNALTPYGVLNLRNQRFSKDYNPIDKDCKCPCCKPGEWGITRTYIHHIVCKETVAAHLLTIHNIHYQLNLMKEIRNAIIHDKFPVFVKKTFDQLYSEKNYPKWAVESLNTVNINLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>M7NM00</accession>
    <name>M7NM00_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">ISWI chromatin-remodeling complex ATPase ISW2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PNEG_01885</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873859.1">
        <property type="nucleotide sequence ID" value="XM_007875668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NM00"/>
    <dbReference type="STRING" id="1069680.M7NM00"/>
    <dbReference type="GeneID" id="19895579"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01885"/>
    <dbReference type="eggNOG" id="KOG0385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_0_2_1"/>
    <dbReference type="OMA" id="VHDYQFF"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17997">
        <property type="entry name" value="DEXHc_SMARCA1_SMARCA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000082">
        <property type="entry name" value="ISWI chromatin remodeling complex ATPase ISW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000002">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase CHR11 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.30:FF:000003">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase ISW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1190">
        <property type="entry name" value="iswi atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.30">
        <property type="entry name" value="ISWI, HAND domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044754">
        <property type="entry name" value="Isw1/2_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015194">
        <property type="entry name" value="ISWI_HAND-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036306">
        <property type="entry name" value="ISWI_HAND-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015195">
        <property type="entry name" value="SLIDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF49">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09110">
        <property type="entry name" value="HAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09111">
        <property type="entry name" value="SLIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101224">
        <property type="entry name" value="HAND domain of the nucleosome remodeling ATPase ISWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="166"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="462"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="15">
        <location>
            <begin position="822"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="101"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="998"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="998"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1009"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1023"/>
            <end position="1041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMR09698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1063" mass="124409" checksum="1C2C1BD08789E86E" modified="2013-05-29" version="1">MSKNSKNNSISDLSEEFDEQKIKSEDELLEEEKLNQKNYRTIINMERQREFVEKHAKLNEAKAVDSTKRLSFLLGQTELFRHFINLQTGANTDSKEIINKLSDEKPKKEMNSKDHRHRKTEQEEDAELLQENDPNQESQTIFTESPPYIVGGKMRDYQVQGLNWLISLYENGINGILADEMGLGKTLQTISFLGYLRFLKDIRGPHLVAAPKSTLDNWSREFSRWIPEINVFVFQAPKDERAGLINERLLTNNFDVCITSYETILREKMHFKKFAWEYIIVDEAHRIKNEESMLSKIIRLLNSRNRLLITGTPLQNNLHELWALLNFLLPDIFADSQVFDRWFESQNGDSDTVVKQLHKVLRPFLLRRVKSDVERTLKPKKETNLYVGLSEMQVKWYQKILEKDIDAVNGAIGRKEGKTRLLNIVMQLRKCCNHPYLFDGAEPGPPYTTDEHIVTNSGKMVMLDKLLKWSKAQDSRVLIFSQMGRVLDILEDYCYLRGYKYCRIDGQTSHEDRIVAIDDFNAPGSDKFLFLLTTRAGGLGINLTTADVVVIYDSDWNPQADLQAMDRAHRIGQTKQVYVFRFVTDNTVEEKVLERAAQKLRLDQLVIQQGRAQLQNKNSASKEELITMIQHGAEDVFKQREGGTMTEDDIEEIMKKGEKRTAELNKRYESLGIDDLQKFSTDSAYEWNGEDYTKKRSTDGTGIKWIYPSKRERTQQSYSLDQYYKGVLKTGGRTHGPPKAPRPPKQINIQDHQFFPQRLIDLQDRETAYFRKELGYKVPLAEGTPEDLEEREAVRDLEQREIDNAVPLTEEEQLEKEKLLLHGFGDWQRRDFYHFIQACAKHGRNSFKALAQEIESKTLAQIKEYSKVFWERYSEIDGYERYIGQIEAGEGRIQKQDRQTKLLHEKISQYRAPLQQLKIIYNQNKGKSYTEEEDRFLLVKLNEYGLGTEDVYERLREEIRISPLFRFDWFFKSRTALELQRRCATLLTSVKRELEMNEEKTDWKRDRSDDNDDDDDDDDLPRKKTRTGVKDKRARSRLKNKHVSEGNHSYISTTRISRSRSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMD6</accession>
    <name>M7NMD6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">N-acetyltransferase ECO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_03217</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. ECO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875280.1">
        <property type="nucleotide sequence ID" value="XM_007877089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMD6"/>
    <dbReference type="STRING" id="1069680.M7NMD6"/>
    <dbReference type="GeneID" id="19896904"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03217"/>
    <dbReference type="eggNOG" id="KOG3014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039183_0_1_1"/>
    <dbReference type="OrthoDB" id="428854at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061733">
        <property type="term" value="F:protein-lysine-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028005">
        <property type="entry name" value="AcTrfase_ESCO_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028009">
        <property type="entry name" value="ESCO_Acetyltransf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13880">
        <property type="entry name" value="Acetyltransf_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13878">
        <property type="entry name" value="zf-C2H2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="N-acetyltransferase ESCO zinc-finger" evidence="10">
        <location>
            <begin position="108"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase ESCO acetyl-transferase" evidence="11">
        <location>
            <begin position="262"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR08377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="38065" checksum="115C60BED348AEB8" modified="2013-05-29" version="1">MGKSIFEDIKNIDLQRRPLRTYQRQRQKTPDFVTIKEKRSEIKTPLSVPLKRYYGENFEVDDPRKILSSPIKSTTLIEKTRVYEFKFGKKKDNYKRRKLFETKSKFTQLCLDLLPSRITCSECGMSYTRGSAADETIHSKFHAKSIKGIDYPITNSIKEVWKENFTSNKIIMITMSSPLSEIKKAKKVLSVVDLELGSASPFPSSMNEHNHLVKQYKFFLYLKGKKCIGLILVEPIQSAYPVYPSSSQSSSITLEPEALSTYIMGVSRIWVCKTYRREKIATLLLDIACNHFIYGITVKKHEVAFSQPSESGKLFIENWTGKKFSVYIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMK2</accession>
    <name>M7NMK2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01663</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873625.1">
        <property type="nucleotide sequence ID" value="XM_007875434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMK2"/>
    <dbReference type="STRING" id="1069680.M7NMK2"/>
    <dbReference type="GeneID" id="19895357"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01663"/>
    <dbReference type="eggNOG" id="KOG2388">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025603_1_1_1"/>
    <dbReference type="OMA" id="YFQVDNP"/>
    <dbReference type="OrthoDB" id="532420at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04193">
        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="483" mass="55641" checksum="9DC8959AD32BF828" modified="2013-05-29" version="1">MELMEKEVEIFYKIYQKYGQEHVWEFYETFCKKEREEFLKQIKTICPDTFNKILFKTIQEEDQKVKGEIKPISLDMLGSTIDASQEELSRWMSIGLENIFHNRVAVILLAGGQATRLGTDGPKGCFDIGLPSHKSLFQLQAERIRRLMTLAQIKYNSSMPVSIPWYIMTSNSNRSATEEFFFKYNFFGLEKNIIFFNQEDIPCFSYTGKFLLETKSKIAVSPNGNGGIYKALLNSNILDDLMVRKIQHIHCFCVDNCLVRVADPIFIGFSIERDLDVSTKVVRKHKASEKVGLVVLKNGKPSIIEYNEIDTKISEALDESSNLLKFRLANIANHYFNIRFLFKISAYESKLPYHISKKKVPFYDIQSKKTIVPETSNAIKLEKFIFDVFSEVSLNKFGCLEVARFDEFSPLKNSLEIEEDNANTSRRDILSQGRRWVEQAHGILIGNPFYGIEISPLVSYAGENLEFMQGKCYQVLSIIENES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMV2</accession>
    <name>M7NMV2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="3 11">2.5.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_03037</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="3 11"/>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875089.1">
        <property type="nucleotide sequence ID" value="XM_007876898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMV2"/>
    <dbReference type="STRING" id="1069680.M7NMV2"/>
    <dbReference type="GeneID" id="19896724"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03037"/>
    <dbReference type="eggNOG" id="KOG2648">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037146_1_1_1"/>
    <dbReference type="OMA" id="PGQVLGC"/>
    <dbReference type="OrthoDB" id="1649088at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11850:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR08557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="425" mass="48731" checksum="5F502F7F1792A8F5" modified="2013-05-29" version="1">MSENNRLSGKYNIKRFIKKIERETNDVEDIEKNVLVKRYNICKEKVIKKIPNDILEDPIINDSINLLPSNYNFEIHKTVWYIRRNGSKKVGLQMPEGLLVFACTISDILERVCMVDVFIMGDVTYGACCIDDFTAKALDCDLLIHYGHSCLIPVDSVSIKTLYIFVSIEINKNHVVETIKMNIPNDTHIALVGTIQFVPSIHSIRPLLENKSNYKITIPQSKPLSPGEILGCTAPVLHNDIDAIIYIGDGRFHLESIMIANPLLPAYKYDPYSGKFTREYYQHKDMKDHRKKAIEKAIKAKKWGLIIGTLGRQGSPKVMENLETQLKEKKIEYIKVLLSEIFPSKLSLFHDIEAWIQIACPRLSIDWGYSFPTPLLSPYEASVALNSIEWKNPYPMDFYANQSLGPWTPIHRQDQQHILPKIQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN10</accession>
    <name>M7NN10_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nuclear distribution protein PAC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Lissencephaly-1 homolog</fullName>
            <shortName evidence="11">LIS-1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">nudF homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PAC1</name>
        <name evidence="11" type="synonym">LIS1</name>
        <name evidence="14" type="ORF">PNEG_02994</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Self-associates. Interacts with NDL1 and dynein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
            <location evidence="11">Spindle pole</location>
        </subcellularLocation>
        <text evidence="11">Localizes to the plus ends of microtubules at the hyphal tip and the mitotic spindle poles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the WD repeat LIS1/nudF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875043.1">
        <property type="nucleotide sequence ID" value="XM_007876852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN10"/>
    <dbReference type="STRING" id="1069680.M7NN10"/>
    <dbReference type="GeneID" id="19896681"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02994"/>
    <dbReference type="eggNOG" id="KOG0295">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_15_1"/>
    <dbReference type="OMA" id="WHVATKE"/>
    <dbReference type="OrthoDB" id="10264588at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051012">
        <property type="term" value="P:microtubule sliding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000342">
        <property type="entry name" value="Nuclear distribution protein PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.30:FF:000002">
        <property type="entry name" value="Platelet-activating factor acetylhydrolase ib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03141">
        <property type="entry name" value="lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017252">
        <property type="entry name" value="Dynein_regulator_LIS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037190">
        <property type="entry name" value="LIS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056795">
        <property type="entry name" value="PAC1-like_LisH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24951">
        <property type="entry name" value="LisH_PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037647">
        <property type="entry name" value="Dynein_regulator_Lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109925">
        <property type="entry name" value="Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 11" id="KW-0813">Transport</keyword>
    <keyword evidence="3 12" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="PAC1-like LisH-like dimerisation" evidence="13">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="111"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="153"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="198"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="344"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR08511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="442" mass="50005" checksum="3AC7E92EB634B732" modified="2013-05-29" version="1">MSLLNDRQKEELYKALLFYFSKSEFPKTFSTFESELSNKGIIININEENEHKYDKLLEKKWTSVIRLQKKIMDLEARLHIAQTELSTIPLDKNHSTDMTSWIPCAPAKHTLTGHRQPITSLAFHSVFTILASASEDSTIKIWDWETGDFERTLKGHTKAVLDIEFNTFSNSNCLVSCSSDLTIKLWDSKNEYKNIKTLYGHDHSISSIKFLPPNGDRIVSVSRDKNIKIWEISTGFCIKTISNAHIDWIRTICPSDDGKLLLSAGNDRVAKIFNTHNGECKLEFQGHEHVIECAIFAPNSAYKFLMQLSGIHLSKNSMGYIATGSRDKTIKLWGCQNGQIIKTLLGHDNWLRALVFHPSGRYLISASDDKTIRCWDLSQSGKCTRIIEEAHSHFINCLCWASESTESTTNGSNEASNNKSPNSKRLAIASGGVDLVIRIWMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN71</accession>
    <name>M7NN71_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02854</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874892.1">
        <property type="nucleotide sequence ID" value="XM_007876701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN71"/>
    <dbReference type="STRING" id="1069680.M7NN71"/>
    <dbReference type="GeneID" id="19896541"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02854"/>
    <dbReference type="eggNOG" id="KOG3165">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081098_0_1_1"/>
    <dbReference type="OMA" id="GMMDCLL"/>
    <dbReference type="OrthoDB" id="76105at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09864">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000035">
        <property type="entry name" value="Fcf1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037503">
        <property type="entry name" value="Fcf1_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="6">
        <location>
            <begin position="63"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="189" mass="21732" checksum="95514166D104DAEE" modified="2013-05-29" version="1">MAKMKKTRYISVKRMISSHEQSLNKSSKKKSESEISKSDFIHEIPRVSSSLFFQYNKSLGPPYHVLVDTNFINFCIKNKIDIIKGMMDCLYAKCIPYITDCVMGELEKLGSKFRIALRIARDPCFERLPCSHFGIYADNCIISRIMQNNCYIVATNDKNLKVLIRKIPGVPIMYVGNHKLKVERLVGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP86</accession>
    <name>M7NP86_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01233</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873152.1">
        <property type="nucleotide sequence ID" value="XM_007874961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP86"/>
    <dbReference type="STRING" id="1069680.M7NP86"/>
    <dbReference type="GeneID" id="19894930"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01233"/>
    <dbReference type="eggNOG" id="KOG3399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043857_3_2_1"/>
    <dbReference type="OMA" id="SSRIYGC"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="13"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="118" mass="13468" checksum="C3D4D3355E77E6D1" modified="2013-05-29" version="1">MGLSYNVYLTGSKIYSCSKCKTHLSDHKEIASKVRNSLLNAFRGQHGRAYLFNTVVNIIESPMSEDRTMTTGRHIVRDISCKQCGSVVGWKYDKAFESSQMYKEGKYILEIELLTMKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP95</accession>
    <name>M7NP95_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EKC/KEOPS complex subunit CGI121</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">EKC/KEOPS complex subunit cgi121</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02428</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. CGI121 is not required for tRNA modification.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the CGI121/TPRKB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874434.1">
        <property type="nucleotide sequence ID" value="XM_007876243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP95"/>
    <dbReference type="STRING" id="1069680.M7NP95"/>
    <dbReference type="GeneID" id="19896121"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02428"/>
    <dbReference type="eggNOG" id="KOG4066">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065847_1_1_1"/>
    <dbReference type="OMA" id="IVCRMST"/>
    <dbReference type="OrthoDB" id="329139at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2380.10">
        <property type="entry name" value="CGI121/TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013926">
        <property type="entry name" value="CGI121/TPRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036504">
        <property type="entry name" value="CGI121/TPRKB_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011465">
        <property type="entry name" value="PRK14886.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840">
        <property type="entry name" value="CGI-121 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840:SF10">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08617">
        <property type="entry name" value="CGI-121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143870">
        <property type="entry name" value="PF0523-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="154" mass="17675" checksum="EE013763687AE46C" modified="2013-05-29" version="1">MHTFKLPNYPSEQVHIALYINIKNLQYIKNLVVSGNLGFQCAFIDASTIISFYQILAAVHNSIRNCKENELRTKNIYSEIIYSLSSTLSIIDAFEKFGITNKTENLIVIKIGGKKEQVENDLKKIINGTEIEPNDSNIEKIRDMIKIYKVKNIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPD1</accession>
    <name>M7NPD1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NEDD8-activating enzyme E1 regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874757.1">
        <property type="nucleotide sequence ID" value="XM_007876566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPD1"/>
    <dbReference type="STRING" id="1069680.M7NPD1"/>
    <dbReference type="GeneID" id="19896421"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02730"/>
    <dbReference type="eggNOG" id="KOG2016">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019618_2_1_1"/>
    <dbReference type="OMA" id="INDSCTE"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030667">
        <property type="entry name" value="APP-BP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039099">
        <property type="entry name" value="APP-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="49038" checksum="926BB1801828B3AD" modified="2013-05-29" version="1">MCELLQELNEDVKGEYLIETLESILIHNPSFFKQFTIVISSIHEDELLLKLEKILWDFDIPLIISYSVGFIGYLRITMPEHTVVETHEENLIDLRIDCPWPALRELASSFNLKNKKNCSYTHIPYILILLNCLDIWKLRNNGMLPCTDEEKQQFKEIIRTYMQGFDKESIEEVLSVSWRASCITSIPDNVQSILKDEKCVHISSESSEFWILCHAISNYVSAEGNGLLPLSGVIPDMKSDSESYIKLQNVYRQKAQEDYECVRKYVQDILLSISQPMSKISDDKIKFFCKQCKYMRILRYRSLKEEYRSPDLKLIKSSFSTPDDLIIWYIALRSYNKYKNIFGKYAGAQQATLDADTDKYIQLTEHFLSKFNCKMTEFQIMACKELIRAGGGELHNIASFIGGVAAQEAIKEFKKTLFTLKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPJ7</accession>
    <name>M7NPJ7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vesicular-fusion protein sec17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01334</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SNAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873262.1">
        <property type="nucleotide sequence ID" value="XM_007875071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPJ7"/>
    <dbReference type="STRING" id="1069680.M7NPJ7"/>
    <dbReference type="GeneID" id="19895031"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01334"/>
    <dbReference type="eggNOG" id="KOG1586">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046329_0_2_1"/>
    <dbReference type="OMA" id="WSVKEYL"/>
    <dbReference type="OrthoDB" id="9984275at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd15832">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000049">
        <property type="entry name" value="Alpha-soluble NSF attachment protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF8">
        <property type="entry name" value="ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00448">
        <property type="entry name" value="NSFATTACHMNT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="32548" checksum="BF2AFB6AED3BD5AC" modified="2013-05-29" version="1">MSDPKSLLLKADKKSSGHGGFLSFFGNKYSEAAELYIEAANAFRLKKQGKEAGEALEKAASMQLKMDEKDDAANTLVEAYKAYRRTDPQDAARVIESAIQMFTFRGNFRRAASYKMDVASLYELELMNSQKALESYDEAGEWYSNDQAEALANKAFLKVAEIAALEEQYSLAIQKYEDVARKSINNNLMKWSVKDYLFKAGICHLNLGDMVATRRALENYVDLDLTFQSTREYKLLEDILHAIESGDSDIFTEKVREYDQLSKLDKWKTTLLLRIKNSINEEPDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPN4</accession>
    <name>M7NPN4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylinositol N-acetylglucosaminyltransferase subunit H conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01368</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIGH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873297.1">
        <property type="nucleotide sequence ID" value="XM_007875106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPN4"/>
    <dbReference type="STRING" id="1069680.M7NPN4"/>
    <dbReference type="GeneID" id="19895065"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01368"/>
    <dbReference type="eggNOG" id="KOG4551">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054079_0_0_1"/>
    <dbReference type="OrthoDB" id="6256716at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044215">
        <property type="entry name" value="PIG-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019328">
        <property type="entry name" value="PIGH-H_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10181">
        <property type="entry name" value="PIG-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidylinositol N-acetylglucosaminyltransferase subunit H conserved" evidence="4">
        <location>
            <begin position="106"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR10668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="190" mass="22709" checksum="D449064899B6A372" modified="2013-05-29" version="1">MPLLIKRPSPDIVEFTYYENFKWSIKYILKLLASFSILVFFLSVSMFFFGQHYQQINCIIYILQNIGLVQSIQELYIHKPYVFFCIVAIFLYFACRLMHPKPTSESLLILHNLGLQITLHYFFLPSRTRFIPLSEILDVVIHEGFIGLEVRYYLALIIRNEDTLQIIFENLLPRRKFLEVVYKEIQTIFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPQ9</accession>
    <name>M7NPQ9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="9">HMG-CoA reductase</shortName>
            <ecNumber evidence="9">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02436</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="9"/>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874443.1">
        <property type="nucleotide sequence ID" value="XM_007876252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPQ9"/>
    <dbReference type="STRING" id="1069680.M7NPQ9"/>
    <dbReference type="GeneID" id="19896129"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02436"/>
    <dbReference type="eggNOG" id="KOG2480">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001734_0_0_1"/>
    <dbReference type="OMA" id="NDWPRAD"/>
    <dbReference type="OrthoDB" id="310654at2759"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3270.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.420:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.770.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025583">
        <property type="entry name" value="HMG-CoA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13323">
        <property type="entry name" value="HPIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0521">NADP</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="10">
        <location>
            <begin position="204"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1052" mass="116715" checksum="79907E04A321CE42" modified="2013-05-29" version="1">MVLTRLASHSSRYPIHTVVIVSLLATTAYIHLFEIARDGGIDFGTSFANNLSLDFRSIEGALVGTKAVDGDWHWEHNKNLYNIEANSLILNILQFDHPYLDKREELVDLFLDMCLKKSNTNMCLFYGNETSSKIILKDLSPLLVFELEQRIQNIRTENLAYSKRKHYLQQNINNPGIIIYWLRNNAYTIVQKIWKHIKDTDIIDIAVLLIGYISMNFVFILLFLNMRTLGSNFWLAAVVLTSGTFAFLFALNTVNYFGDNINPLVLSKKIPFLAVTVGFEKPSLLTRAVLNSSPDINTNPIRENVVNAVRDKGWIIVRDYLFEIGILILGAMSGVDGLNQFCKVAAWILGFDCLLLFTFYIAVLSIKLEINRIKQRAGVQSIFEKNILLQETIYDITNNNSCIPSNNVNEKKPANIGIYNVFGYHNVKESSISRFKLIMTSCFFLINFLNLCTFPFQTVNHLKSSSSKEFRIIRINPLEIYEILDLLDKLTQDIHPSIRKVSLNVLPVFTLKAINKPFSVDAVLESLELWAKSISDPIMNKWIMIILILSIIFNAYLFNVTRWVTPVQISLKTQDSSSHMIEEIKKITDNTSSYLEKDLYGNISNNSEIRSIDKCEELLKKGLSTLMQDEEILQLTLNSKIPSYALEKVLNDPERAVKIRRSFISRKSGTNVLETLALPFKDYDYARIMGACCENVIGYVPIPVGVAGPLLVDKIEVYLPMATTEGVLVASTARGCKAINASGGVTTILVQDLMTRGPCVSFPTVSRTGMVKAWLDTEQGQNAIKKAFNSTSRFARLSSVKSTIAGTNLYIRFSTTTGDAMGMNMVSKGVENVLKVMIKDLGFDDMRIISISGNYCTDKKPAAINWIEGRGKSVIAEATILKDIVKSVLKCNVDDLVELNISKNLIGSSMAGSVGGFNAHSANIVAALFIALGQDPAQVVESANCITLMKNINGNLHITVSMPSIEVGTIGGGTILEPQSALLDLLGVRGPHPTIPGNNAKRLARIIAAAVLAGELSLCSALTAGHLVKSHMQHNRSSLNTPISSCSSTPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPT6</accession>
    <name>M7NPT6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWR1-complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02464</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SWC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874473.1">
        <property type="nucleotide sequence ID" value="XM_007876282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPT6"/>
    <dbReference type="STRING" id="1069680.M7NPT6"/>
    <dbReference type="GeneID" id="19896157"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02464"/>
    <dbReference type="eggNOG" id="KOG2656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018539_4_1_1"/>
    <dbReference type="OMA" id="GNTTMYQ"/>
    <dbReference type="OrthoDB" id="19740at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000087">
        <property type="entry name" value="DNA methyltransferase 1-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032563">
        <property type="entry name" value="DAMP1_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008468">
        <property type="entry name" value="DMAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027109">
        <property type="entry name" value="Swc4/Dmap1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855:SF10">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05499">
        <property type="entry name" value="DMAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16282">
        <property type="entry name" value="SANT_DAMP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="126"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="384"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="440" mass="51273" checksum="5CF2ABDCB0797E1C" modified="2013-05-29" version="1">MTSSDIRDVFNLQEMGISKPVPRVKPKIHSEKKSEFITRELYSLLGENTPPIAILQNKFKNRPKLRQKAASWVWTSFVNGARKDGHLFSHWVRAGDGENEEYRFEKLNKKVNIIAYSNEEYALNLTALDWSREETDYLFSLCREYDLRFVVIADRYDYKGNQRTMEDIKDRYYTVVRKILMARTPIAMMTPTQTEELNQLYYNKEKEISRKKHLASLAMRTPEEIAEEEALFIESQRIEAYRKKMAQERKELLRLLEAPVPNGSIAKYTSSQGLGILTNNILIADKNKKRKNSENTSSHTFSGSIGSQKDAIFKKIRKLSSREENIYGVSWHEKLQAGIYLRSTRLSMAKSTVATKISTILTELGLATRLTMPTEKTCAKFEQLQRSIELLLDAKKHLDRLEQERRISEVRIQETPLDDLETKTTDLQTDILKLQRRFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPU0</accession>
    <name>M7NPU0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02469</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874478.1">
        <property type="nucleotide sequence ID" value="XM_007876287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPU0"/>
    <dbReference type="STRING" id="1069680.M7NPU0"/>
    <dbReference type="GeneID" id="19896162"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02469"/>
    <dbReference type="eggNOG" id="KOG3235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_7_2_1"/>
    <dbReference type="OMA" id="LPENYFM"/>
    <dbReference type="OrthoDB" id="25586at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000037">
        <property type="entry name" value="N-alpha-acetyltransferase daf-31-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="202" mass="23443" checksum="0746F77C1541BEB9" modified="2013-05-29" version="1">MNIRLARVEDLPGMQQVNLTNLPENYQMKYYLYHLLTWPQLSYVATNAKNRIIGYVLAKMDETDDTSQQGHITSLSVLRNYRRLGIAAQLMRQSQQAMVDNFQAKYVSLHVRKTNRAALKLYRNNLNFVVVGVEKEYYADGEDAFLMRCDLGHLKEPGIDIFTSEEVSSETCLSTRRDITNKNMRVSDMMEQLTEETQQFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPX2</accession>
    <name>M7NPX2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874246.1">
        <property type="nucleotide sequence ID" value="XM_007876055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPX2"/>
    <dbReference type="GeneID" id="19895950"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02257"/>
    <dbReference type="eggNOG" id="KOG0013">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070348_1_0_1"/>
    <dbReference type="OMA" id="GCMGRYL"/>
    <dbReference type="OrthoDB" id="1640476at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.225.20">
        <property type="entry name" value="Ub domain-containing protein, DC-UbP/UBTD2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032752">
        <property type="entry name" value="DC-UbP/UBTD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038169">
        <property type="entry name" value="DC-UbP/UBTD2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039869">
        <property type="entry name" value="UBTD1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13609">
        <property type="entry name" value="UBIQUITIN DOMAIN CONTAINING 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16455">
        <property type="entry name" value="UBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="184"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="256" mass="29193" checksum="B1DE84F15AA10E38" modified="2013-05-29" version="1">MGCSFSKHPSSYRGFREDFRETRNIYGNLNTRTHIPTCNLCRRNNSLKIPRVCTWVSDHPITMSNLIRRRKEFWETAASYGGSLEIWNTLRLVLETIPESLTTAQTIINTAGIILPTGDLIDGCYDQRGSYYFIPPYIFSEPTNLISENPEQSKNDKLNSIIENEENTKLSESQDSQIKNEHVNEIIVRLSDTSKDILIKIDSKNSIADMKQHVAKIAGIKKPMHFFLLGKMLSDEKSLIDQGWKEGRVVQALILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQB8</accession>
    <name>M7NQB8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02409</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874415.1">
        <property type="nucleotide sequence ID" value="XM_007876224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQB8"/>
    <dbReference type="STRING" id="1069680.M7NQB8"/>
    <dbReference type="GeneID" id="19896102"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02409"/>
    <dbReference type="eggNOG" id="KOG0679">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027965_6_2_1"/>
    <dbReference type="OMA" id="MTEAPWN"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13395">
        <property type="entry name" value="ASKHA_NBD_Arp4_ACTL6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000184">
        <property type="entry name" value="NuA4 histone acetyltransferase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR09467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="46430" checksum="36C77D733A2248A0" modified="2013-05-29" version="1">MTTQIYGGDEISAIVLDPGSQHTRAGYAGEDTPKCVIESSYGLLVENNRSEIVFGDNSIHAPRAGMEIKNPMLEGIVHDWDIASQIWLYAIKTSLRVDPTEHPLLVTEPSWNPPKNREKTMEIVFEKFGSPAFYLAKNAVCASFANGKSTALILDVGAQVASVTPIYDGLVLKRGVMKQNIAGNYLSAQARAYFSRANIPIVPHYMVKKKLPVDIEAPSRAELRKFLDIRDSFHVFQQDRVMQEFKESICQVFEKSLSESIPSSRPAKAFEFPDGYNLLIDIDRYKVPEVLFNPSFLATEFPEIIPPENSMSLAQLLYNSAMACDTDIRATLLGNIIITGGTSLIQGFGDRVLTELQLLAPGSRIKINASGNTVERKYASWLGGSILASLGTFHQLWISKKEYDEEGDRASLIEKRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQG6</accession>
    <name>M7NQG6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00567</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR10963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872461.1">
        <property type="nucleotide sequence ID" value="XM_007874270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQG6"/>
    <dbReference type="STRING" id="1069680.M7NQG6"/>
    <dbReference type="GeneID" id="19894265"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00567"/>
    <dbReference type="eggNOG" id="ENOG502QRF7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019904_1_0_1"/>
    <dbReference type="OMA" id="ACEQNGR"/>
    <dbReference type="OrthoDB" id="245697at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17742">
        <property type="entry name" value="BRCT_CHS5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13945">
        <property type="entry name" value="Chs5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031673">
        <property type="entry name" value="Chs5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052827">
        <property type="entry name" value="CHS_Export/Cell_Fusion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031669">
        <property type="entry name" value="Fn3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351:SF1">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16892">
        <property type="entry name" value="CHS5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16893">
        <property type="entry name" value="fn3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="81"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="169"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="40198" checksum="F56AA4FC0AA5257C" modified="2013-05-29" version="1">MNDKDISKIQFTVGKVDAGITILLTSDYYLVEFPSLLLPHGIQTGSILDISISRNHEAENKEKEDFQELQKKIHTTFGIKKPTAPLLRVKNVTQTSVVLEWDPIELGTTELRSLTLYKNGLRLGKIPKATTTTSTKLSGLALNTEYSFQLVLKTSGGTYFSEFIIVRTHKMTDLSGITVCIGELNENDKKELEQTIKRIGAKPLQSKVKIDTTHFITSKTSGSEYKKAISMNIPVVTLDYIRSCDAEKKIVNVCKYYFDSSPFFGKQSPDNSELIKDSQNSFNSVTKKNQDIENLEKNNFNSLVISDSVNLQTSLFTDRTSDEINRTLIRELSPKPISEEDENNSLEKLDEEVTTFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQM0</accession>
    <name>M7NQM0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Guanine nucleotide exchange factor MSS4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00622</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872520.1">
        <property type="nucleotide sequence ID" value="XM_007874329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQM0"/>
    <dbReference type="STRING" id="1069680.M7NQM0"/>
    <dbReference type="GeneID" id="19894320"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00622"/>
    <dbReference type="eggNOG" id="KOG4113">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132754_0_0_1"/>
    <dbReference type="OMA" id="IKYLACC"/>
    <dbReference type="OrthoDB" id="30840at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007515">
        <property type="entry name" value="Mss4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13276">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR MSS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13276:SF0">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR MSS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04421">
        <property type="entry name" value="Mss4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51796">
        <property type="entry name" value="MSS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR11023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14612" checksum="9A7C1520D1CF92FA" modified="2013-05-29" version="1">MSDNKEITERIRNSDILYCPYPKCKSVILLKGMGVLVYRRNRILDNSCKLPSNAMSTFWTVSSPFIFENLGFSNDIEGNIKFLICADCDRGPLGYHDPNVLNNGEKEYLLATDRVIYGLSNDTDENYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRI9</accession>
    <name>M7NRI9_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873608.1">
        <property type="nucleotide sequence ID" value="XM_007875417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRI9"/>
    <dbReference type="STRING" id="1069680.M7NRI9"/>
    <dbReference type="GeneID" id="19895342"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01648"/>
    <dbReference type="eggNOG" id="KOG4253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044758_0_0_1"/>
    <dbReference type="OMA" id="YFYYALP"/>
    <dbReference type="OrthoDB" id="4218123at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470:SF1">
        <property type="entry name" value="CHORISMATE SYNTHASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="323" mass="38575" checksum="7BC5928F037DAF8C" modified="2013-05-29" version="1">MFLLFPRMIYSILIKKIFYQLKRPLSKSTIRAISFLFLSSLFFLIFELSLFFPENIILKTSSGIQTPEITLIARLTRLRRITEYDWKLLHRLKSLNGRLLYVLYGPSTLGLCEWCEIETPSTFLYYTIPHVFLCYLVNLGIIYLSISVLSEKIGKLLKKLIFIILFLFFILELIMLNIYDWKSNAYINSASNINWIHWNLKKYRLFLIVTLNLSVAFIIWVINTNILYQIPNKERQLIFSINNLEESINRIRALVIMKRALIKDTFLQEQKMKFYQEKRLKELSDSMNVKDIKKKISHDNMKKILEEIENYAENLIKYMDMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRN6</accession>
    <name>M7NRN6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Endoplasmic oxidoreductin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PNEG_00431</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">B123</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">May function both as a monomer and a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872309.1">
        <property type="nucleotide sequence ID" value="XM_007874118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRN6"/>
    <dbReference type="STRING" id="1069680.M7NRN6"/>
    <dbReference type="GeneID" id="19894129"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00431"/>
    <dbReference type="eggNOG" id="KOG2608">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023061_1_0_1"/>
    <dbReference type="OMA" id="CYKDRLH"/>
    <dbReference type="OrthoDB" id="269384at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007266">
        <property type="entry name" value="Ero1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037192">
        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613:SF0">
        <property type="entry name" value="ERO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613">
        <property type="entry name" value="ERO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04137">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017205">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110019">
        <property type="entry name" value="ERO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 17" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="90"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="398"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMR11408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="537" mass="63552" checksum="D6BB4E1AF8006ECE" modified="2013-05-29" version="1">MSRWWLLISIIVFIFSWSLIDFSSNYYKKEKRWLLDVAIYPVPFSLVERIVSELDPLLKNLTFQTDYFKYYRLNLFAARCPFWGTDNGLCGNKACMVDVLEDSSLPEAWKPSTLGKIRGLTAEQPYRPEKTTKLPFEGALGSETSERCVYEESDYSDRDYCIPEDESVEENIVYVSLVDNPERYTGYSGESAYQVWRAIYRENCFDVPHNFVDPMTKNISLSSSKLEAIMMHKDNWGSKDNDEKRRNAMVQESICLEKRVFYRIISGMHASISTHLCKEYLNKTTGLWEPNFQCFMERVGNYFDRIENIYFNYLLILRALAKLDKYLQNYTFCEGDVESNMMTKYKLNKLISKISFIPKLFDEKLMFDTSHNSFAIHLKDEFRMRFRNVSKLMDCVSCDKCRLWGKIQIAGFGTALKILFEFDDFLDQNKFLLRRTELVALINTFDRISSSIRFIQESSIISFNKNKNFYKLNNCHGFYFFSKIKKIILYKSSFNFKRIIKSFSVEYNNVKDVLIYIINSWFRIFKTIYIYIKGKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRQ8</accession>
    <name>M7NRQ8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CobW/HypB/UreG nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_01955</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873932.1">
        <property type="nucleotide sequence ID" value="XM_007875741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRQ8"/>
    <dbReference type="STRING" id="1069680.M7NRQ8"/>
    <dbReference type="GeneID" id="19895649"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01955"/>
    <dbReference type="eggNOG" id="KOG2743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017452_0_1_1"/>
    <dbReference type="OMA" id="GHSHMDP"/>
    <dbReference type="OrthoDB" id="258627at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="entry name" value="CobW-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051316">
        <property type="entry name" value="Zinc-reg_GTPase_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748">
        <property type="entry name" value="COBW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748:SF31">
        <property type="entry name" value="ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90002">
        <property type="entry name" value="Hypothetical protein YjiA, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="8">
        <location>
            <begin position="6"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="CobW C-terminal" evidence="9">
        <location>
            <begin position="270"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR09771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="38199" checksum="4128F0DBB2AB6169" modified="2013-05-29" version="1">MAEKVPLTILTGYLGSGKTTLLNYILEKQQAKKIAVILNEFGDSSDIEKSLSVSTNGQISEEWIELNNGCMCCMIKNNSVMAIEKLISKRGGFDYILLETTGLSNIGSIVSMFWVDDSLESLLYLDAVVTVIDSYNIIRDLENVSNEHGTTIAHVQISHADVLIINKIDLLNEKQLQIVIKRIKGINSEAKMIFATYSRIEDVSSILNLHAYDNKSTLSMEPKEITYHDPNVTTVTVQLRVLKDEAQKSQLERWIQSMLWEGEILSGSSDKYPVEIYRLKGRIMLQNASWLVQGVRELYEFIPEPTSNTFLSSKLIFIGKGLFQIPLQNILDTFMNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRT6</accession>
    <name>M7NRT6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-splicing endonuclease subunit Sen15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00479</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872364.1">
        <property type="nucleotide sequence ID" value="XM_007874173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRT6"/>
    <dbReference type="STRING" id="1069680.M7NRT6"/>
    <dbReference type="GeneID" id="19894177"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00479"/>
    <dbReference type="eggNOG" id="ENOG502SC4F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121521_0_0_1"/>
    <dbReference type="OMA" id="MKPRQND"/>
    <dbReference type="OrthoDB" id="10002170at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018593">
        <property type="entry name" value="tRNA-endonuc_su_Sen15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28582">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28582:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09631">
        <property type="entry name" value="Sen15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen15" evidence="3">
        <location>
            <begin position="28"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR11463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="126" mass="14911" checksum="C0F13645EE221FD5" modified="2013-05-29" version="1">MEQHILTFPPKELTKYSFLETYGLLYSVYTDLLLSQFWLKLKIHCLPSNRSIIEGISPQNHKTLYVYPCSYKENVSIEKLNKLYQEFRNIRNEDEPLLLGIVSSDSTIVYYKMNEGLVKPRRNDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRU5</accession>
    <name>M7NRU5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Anoctamin dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01997</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873977.1">
        <property type="nucleotide sequence ID" value="XM_007875786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRU5"/>
    <dbReference type="STRING" id="1069680.M7NRU5"/>
    <dbReference type="GeneID" id="19895691"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01997"/>
    <dbReference type="eggNOG" id="KOG2513">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010867_0_0_1"/>
    <dbReference type="OMA" id="YNGPLKT"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049456">
        <property type="entry name" value="Anoctamin_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20877">
        <property type="entry name" value="Anoctamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="504"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="551"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="588"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin alpha-beta plait" evidence="7">
        <location>
            <begin position="16"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="6">
        <location>
            <begin position="167"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="674" mass="80586" checksum="629BFBFDD1BEBBE4" modified="2013-05-29" version="1">MDKIKISQLSDKNIPVDYVICFYYDKTLKKTVEQFKKLVQRLSEVGLNVECYNDSLNSIFLFISCSSSRLHLEASISRRKDWLYGIEKVSPYIKDDEKITVSERLRLVYDIISSPVSEGGAGICPDLNEWKMVKFIFPLHDYRFNKDYMDRILKKWVINESDLDILKNHFGEKIALYFFFIQFYILWLIFPTIFGLFIHFFFPKYSIVFAITITLWSIIFIQMWKKTEVKLSVRWGVYGISKIYQRRGSFIEDKTGKDVITRQTIFFFSILKWLFRKIVSFLFQMVFSIVIICILVGIFFVELYFLEIYDGPFQKYLVIVPTVLFMIFISIFSVIYNILSTYINYYENHETDIDFESSSIRKAFLVNFIISYTSLFMISCFYVPFGSDIIPKINILNIQSIFTDSQNIRIKLFTVNSDKLKKQFIYYMITARAINFFKQWTFPFLSRFFFSILRRIYTTKFLKIGHEDTNSSSKEFEFLRKIRAQMELPEFSVFDNYLELIIQFGYILLFSIIWPLGSLCSLLSNIIKIISDYIKLLLATKRSIPFRTDTIGFWSSYLTLLSWLGTIVMTILIYFHNYSLNTYIFSEFIVLGIFSNYLYIILYTIFKKIFGYIFHEEKYILRKYYSLKNDHLKRSMDQDTAKYREHQYIKYDYTNVIETGTSIITDFFKKYKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NS16</accession>
    <name>M7NS16_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00556</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872449.1">
        <property type="nucleotide sequence ID" value="XM_007874258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NS16"/>
    <dbReference type="STRING" id="1069680.M7NS16"/>
    <dbReference type="GeneID" id="19894254"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00556"/>
    <dbReference type="eggNOG" id="KOG0941">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1504067_0_0_1"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF444">
        <property type="entry name" value="HECT DOMAIN CONTAINING UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="21"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR11548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="179" mass="21259" checksum="712FC2859883A7B6" modified="2013-05-29" version="1">MFAGYLFAKMKKKLIFNISLEYVKRYTSFILDTSISKQFEPFKREFYHVCRRNALFLFRSEEIELLIRRSRSLDVDQLRAVALYDSSNSSEVNSEKVIQCGSNFAKKITCIRYRIESYFCYRSTNLLFKIFILGNDCNRYSIAHTSNFNQLCIYRYETREKLCNFLITAIFDSEGFGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M7NS20</accession>
    <name>M7NS20_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">GTP-binding protein LepA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01828</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GTP-binding elongation factor family. LepA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873799.1">
        <property type="nucleotide sequence ID" value="XM_007875608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NS20"/>
    <dbReference type="STRING" id="1069680.M7NS20"/>
    <dbReference type="GeneID" id="19895522"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01828"/>
    <dbReference type="eggNOG" id="KOG0462">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009995_3_1_1"/>
    <dbReference type="OMA" id="QVKCDEN"/>
    <dbReference type="OrthoDB" id="1074at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03699">
        <property type="entry name" value="EF4_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000078">
        <property type="entry name" value="Elongation factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000015">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000007">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2570:FF:000001">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000004">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="entry name" value="Elongation factor 4, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512:SF7">
        <property type="entry name" value="TRANSLATION FACTOR GUF1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="TRANSLATION FACTOR GUF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="55"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="129"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="183"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR10077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="652" mass="74481" checksum="97B4E581554811C6" modified="2013-05-29" version="1">MKRLFFVEKHKINKGYLYCLRFNNANTYYIFRKNIGTSYEKDKDIVKKIRNIECLNIRNWAIIAHINHGKSTLSDRLLEITGTISESGKNRQVLDKLKVERERGITVKAQVCSMLYDYKEETYLLNLIDTPGHVDFRAEVNHSLAICDGCLLLVDACQGIQSQTVANYQLALSRGLVILPVLNKIDMPNSEPEKILNQLKQTFNIVPEDVILVSAKKGTGTEKIIPYIIDKIPPPKGSLMNDLKCFLIDSWYDHFDGVIVLVKIYDGCLRKGDKIQSICTSLKYNVAEVGIMYPDRVSTELLKAGQVGYVILGMKNSEEFYIGDTFYHVGKDVNPLPKFKELKPTIFVGAFPVDANNFQKLNESIKHLLLNDRSIFVEKESSSALGQGWRIGFVGTLHLSVFKDRLKNEYNEEIIVTSPTVPFKLIYKNGKEKMISNPSLFPDIIDIKRDVLNLEEPVAEVTMVFPFEYLGHVIELCENNRGVRKEIIFPSEENCILKYDIPMVLLIDNFFEKLKSLTKGYATLDYRIIGYKISDLVKIKLLINGNPIDALSTVLHRSQVNIKGKEFVRHLKSLIKQQLFEVIIQAVVENRVIARETIRPLKKAVTAKCYGGDVTRKMKLLSKQKKGKKKLKKIGNVIVDHTVFQKFLKKYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NS30</accession>
    <name>M7NS30_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873643.1">
        <property type="nucleotide sequence ID" value="XM_007875452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NS30"/>
    <dbReference type="STRING" id="1069680.M7NS30"/>
    <dbReference type="GeneID" id="19895374"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01680"/>
    <dbReference type="eggNOG" id="KOG1772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125101_2_0_1"/>
    <dbReference type="OMA" id="KARECRA"/>
    <dbReference type="OrthoDB" id="250802at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01147">
        <property type="entry name" value="V_ATP_synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713:SF11">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="31"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="134" mass="15399" checksum="B6CC812830688FBC" modified="2013-05-29" version="1">MSVEGSSGIQTLLEVEKESQKIVQKARECRAQGLKNARSEAQAVIEEYRAQKEEAFEKYKKELARFNLKEEELHNKVLNEKLENIRQHAASKKGETIEKMIEIFTTGSLEIHPNASLQIYQDLSIKNLEQKPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NS34</accession>
    <name>M7NS34_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01685</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873648.1">
        <property type="nucleotide sequence ID" value="XM_007875457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NS34"/>
    <dbReference type="STRING" id="1069680.M7NS34"/>
    <dbReference type="GeneID" id="19895379"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01685"/>
    <dbReference type="eggNOG" id="KOG1201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_5_1_1"/>
    <dbReference type="OMA" id="HGHIVNM"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05339">
        <property type="entry name" value="17beta-HSDXI-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR09926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="268" mass="30327" checksum="39F77C22EB0373D5" modified="2013-05-29" version="1">MLINNFAGASGLGYELSLILSRLGAIVIIIDIAEKKISDRKKVFFKQLVLKLKAFCHYYRCDVTCVRGLEKVLLEIKKHFGIPTILVNNAAIIDGESIETMSFEKFRRVVDVNFISHFNTVKLFLPGMKQKNEGHIVTIASSLAFIGVTNLSAYCASKTALVSFHESLKYELLYSNSNIRTTLVVPGQLNTSLFQNVKTPSRFLAPVLDPVYVAEKIAKTIINDMGIEIYTPLYCLILPMLRCIPIRFQRIFRYFSGIDKATYVFIKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSB9</accession>
    <name>M7NSB9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoplasmic reticulum lectin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Protein OS-9 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00086</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
            <orientation evidence="1 7">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the OS-9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871943.1">
        <property type="nucleotide sequence ID" value="XM_007873752.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSB9"/>
    <dbReference type="STRING" id="1069680.M7NSB9"/>
    <dbReference type="GeneID" id="19893784"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00086"/>
    <dbReference type="eggNOG" id="KOG3394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084014_0_0_1"/>
    <dbReference type="OMA" id="SMTIHVP"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045149">
        <property type="entry name" value="OS-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012913">
        <property type="entry name" value="OS9-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM LECTIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414">
        <property type="entry name" value="OS-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07915">
        <property type="entry name" value="PRKCSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0430">Lectin</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="9">
        <location>
            <begin position="116"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="327" mass="39136" checksum="9DCDF8217F8FB8D9" modified="2013-05-29" version="1">MKKNIILWIILPFIHIYGFSVYDDILSQPRYQINFKKMPISRGIVNDRLLTDNRTHKDDIEYEILKLKNEEYLCTIPKVNDELIENEETPEEKIKKEQEADKALEKGLKLLSSMENTCIYYLEGWWTYVFCYNKYAKQFHQKEWDGTQRGLRMLENQSENYYFLGKLNATTKKKEPELPSKIEYNGDSYYISQRMHGGTYCNLIQDNRHIEIQYICEPDTYDKIMFISEVSTCSYKMIVHTSKLCKESFFNQINNKNVHIVSCEKILNNNEYAELMNVLYPKTPNNLRLDLFFSNLNVKHIAKQKRKKRIEKNRNTFNSSYIYKNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSE4</accession>
    <name>M7NSE4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="13">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_03595</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP phosphatase family. PP-2B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="13"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873599.1">
        <property type="nucleotide sequence ID" value="XM_007875408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSE4"/>
    <dbReference type="STRING" id="1069680.M7NSE4"/>
    <dbReference type="GeneID" id="19897282"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03595"/>
    <dbReference type="eggNOG" id="KOG0375">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_6_2_1"/>
    <dbReference type="OMA" id="YPAACNF"/>
    <dbReference type="OrthoDB" id="5593063at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07416">
        <property type="entry name" value="MPP_PP2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041751">
        <property type="entry name" value="MPP_PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="14">
        <location>
            <begin position="168"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR10187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="538" mass="61930" checksum="28A0B25DC4C08939" modified="2013-05-29" version="1">MGNFKKKTSKNSPKIDFTVFQMENGKIVRTQERICKDVQAPVTHIPTDAQIFIVDENGVKKPNVQFIKNHFYREGRISEDHALWIIREGTSIFRNEPNLIEVEAPITVCGDIHGQYYDLMKLFEVGGNPCETSYLFLGDYVDRGYFSIECVLYLWALKICYPNSFYLLRGNHECRYLTDHFTFKLECKHKYSENLYDVCIESFCSLPLAAIMNKQFLCIHGGLSPELNVLDDLNTIDRFREPPIHGIMADLLWSDPSEEFGEEKTDDFFVYNHVRGCSYFFSYAAVCTFLERNNLLSIIRAHEAQDSGYRMYRKTKTTGFPSVMTIFSAPNYLDIYNNKAAVLKYENNIMNIRQFSSSPHPYWLPNFMDAFTWSLPFVGEKIIDAFISILSICSEDEINDENSTKQSDSSVTDLAESEQRRQVIRNKIFAIGRLSRVFHLLRQESESITELKTISGNTKLPAGTLILGSEGIKHAITTFNDAKSSDIENERFPPPKNDINKKYDLIFENSLCQTDDGHDFINKLLKKLSPKASKKQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NT24</accession>
    <name>M7NT24_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873062.1">
        <property type="nucleotide sequence ID" value="XM_007874871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NT24"/>
    <dbReference type="STRING" id="1069680.M7NT24"/>
    <dbReference type="GeneID" id="19894845"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01148"/>
    <dbReference type="eggNOG" id="KOG1104">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013816_0_0_1"/>
    <dbReference type="OMA" id="AYMILEV"/>
    <dbReference type="OrthoDB" id="10252707at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027159">
        <property type="entry name" value="CBP80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015172">
        <property type="entry name" value="MIF4G-like_typ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015174">
        <property type="entry name" value="MIF4G-like_typ-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412">
        <property type="entry name" value="CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412:SF2">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09088">
        <property type="entry name" value="MIF4G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09090">
        <property type="entry name" value="MIF4G_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G-like type 1" evidence="1">
        <location>
            <begin position="259"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G-like type 2" evidence="2">
        <location>
            <begin position="460"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="745" mass="87155" checksum="72DEC2494F69FADA" modified="2013-05-29" version="1">MLIIDFEDETLHNGILSTFRDHIIELPMKIPFLATVISLASTKEASIGKYTVEFMATAAQAFLDGGEWRKFKLILRFLVYATSIIDGDGVLNILDGLTQRIFEVSRDMSEKGDFNTKFHADELTYVFLITVPYVIARSTEVSCGFDTLFSYVDRIEPYMRYRSVDLSLLQPFIEDEASSDVEILEELWNQVQYMKNGKYDANIFLRPWLKFEIQLANTPKFALPPIVLPKTFDNVGRFYFPESHFRIFDQSDQINLSSQTIASSIIRDIVGDIIDIMEFNRKEAARFLADLSFYFAPNLFVSETFSSEMNDMMGTLTEWKSEEIILETIFRRLFRLPKPLQPPIYYHSLLIELCKLIPKKIAPSLGYIIRYIYQALPRLDPEISFRFWTWFSHHLSNFNFSWKWDEWISDLELDLMHPKRTFIRETIEKEICLSYYSKIKESLPEAYHILLPEEPSGPYFDYELPNSKYYAEVGTLLETMKVNTEQSETDVALEIIEKTAIENNENDPPYEALKALVQCVLHLGAKSFSHALNTIERNLPGLQARCNANEKTRRQTIDIIIRFWKDQPTIGTTLINKFLNYSVIDAVSIIEWIILDADIEYVGRSFTWELMKIALNKVNSTPVQIKDRINMETSHNEPGSLSNYRKVYDEVYMKREAVFVTIFEKFPKLFDRAKVSQKKSNGVEKNKTLDNQIEWQLWWAKGLFKEIARRYYYEISNLSNTLNPVIKNKYIKEIFEKVRNLNKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTD7</accession>
    <name>M7NTD7_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD phosphatase, family IIIA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873556.1">
        <property type="nucleotide sequence ID" value="XM_007875365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTD7"/>
    <dbReference type="STRING" id="1069680.M7NTD7"/>
    <dbReference type="GeneID" id="19895294"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01599"/>
    <dbReference type="eggNOG" id="KOG2961">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056221_3_2_1"/>
    <dbReference type="OMA" id="MLMANMM"/>
    <dbReference type="OrthoDB" id="198652at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027706">
        <property type="entry name" value="PGP_Pase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010021">
        <property type="entry name" value="PGPP1/Gep4"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01668">
        <property type="entry name" value="YqeG_hyp_ppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF25">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROPHOSPHATASE GEP4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09419">
        <property type="entry name" value="PGP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="190" mass="21724" checksum="3AAF93D85B700759" modified="2013-05-29" version="1">MNIKAIIPSISSLFSPSSLVPHIIINNFSQIPTNISEVLKNKFRHFSDLDINIQAIILDKDNCITVPGELELYPSYNEKWQQLKQNYNQIFILSNSSGTFTKKYQDEALILEQKLDVSVLRHKKKKPQCFPDIISFLTQNLAISPSQTIVIGDRLFTDILMGNKIGAWTIWIQNGISTKYNKVFLSFPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTF9</accession>
    <name>M7NTF9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lon protease homolog, mitochondrial</fullName>
            <ecNumber evidence="11">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PIM1</name>
        <name evidence="17" type="ORF">PNEG_01272</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homohexamer or homoheptamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12 13">Belongs to the peptidase S16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="11"/>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873196.1">
        <property type="nucleotide sequence ID" value="XM_007875005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTF9"/>
    <dbReference type="STRING" id="1069680.M7NTF9"/>
    <dbReference type="GeneID" id="19894969"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01272"/>
    <dbReference type="eggNOG" id="KOG2004">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004109_1_0_1"/>
    <dbReference type="OMA" id="WLTNIPW"/>
    <dbReference type="OrthoDB" id="2411602at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035694">
        <property type="term" value="P:mitochondrial protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141164">
        <property type="term" value="P:mitochondrial protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070407">
        <property type="term" value="P:oxidation-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000021">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5270:FF:000001">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1480:FF:000003">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.40:FF:000010">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000015">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03120">
        <property type="entry name" value="lonm_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027503">
        <property type="entry name" value="Lonm_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718">
        <property type="entry name" value="LON PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718:SF2">
        <property type="entry name" value="LON PROTEASE HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 11 12" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="16">
        <location>
            <begin position="146"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="15">
        <location>
            <begin position="850"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 12">
        <location>
            <position position="942"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 12">
        <location>
            <position position="985"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="572"/>
            <end position="579"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMR10567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1045" mass="117379" checksum="E30A9FEC39B79952" modified="2013-05-29" version="1">MIFSVSLLLGQKYYSKNLKMNHIYSRKGTFLYPTIYRTCLLSSYHGFLYQISSFLKDLGHKKLYMDEKFQEKKKNIIFKKYSLEGPNFFKECLIGFPLYGNRRFSTSSFIFRSSGSGGNHGKGKFNGKNQEHGLQKPVVPEVYPRMMALPILRRPLFPGFYKAIVIKNPSVIEAIKEMIRRSQPYIGAFLLKEDVDTDTITNINQVYSVGVFSQITSVFPANNVGDENALTVVLYPHRRIKIVDLIKPQTNINGVKNSENISTDNNNDHPGYEDSSSQTYVADQNVEDGFVKGPVNDSSVNDDSHYATSFLNAYDVSLVNVENLIDESFDPKNNIIRAVTSEIVSVFKDIATFNPLFRDQIANFSMFQSTGNVFEEPAKLADFAAAVSAGEISELQDILETLSIEARLQKSLLVLKKELMNAQLQSKISKDVESKIQKRQREYYLIEQMKGIKRELGLETDGKDKLVEKFKDKVSKLSMPENVKKTFDEELNKLIYLEPSASEFNVTRNYLDWLTQIPWGQRSIENYDINYAIKVLDEDHYGLKDIKDWILEFIAVGKLRGTVEGKILCFVGPPGVGKTSIGKSIARALNRQFYRFSVGGLTDIAEIKGHRRTYVGAMPGKIIQSLKKVQTENPLILIDEVDKIGRGHQGDPSSALLELLDPEQNSSFLDHYLDLPVDLSKVLFVCTANITDHIPVPLLDRMEIIHISGYVADEKMAIAKNYLVPEAKELAGLKDIDVNLTNDAIELLIKYYCRESGVRSLKKYINKVYRKSTLNIVKTLGNTFEEESLIDEKKDHVNEQNNLAAHSSKSAEKVRKPLKVPDTISITIDSSNLKDYVGPPIFTTDRLYEKTPPGVVMGLAWTSQGGAVLYVESILENALSSKSKPGFTCTGQLGNVMKESSTIAYSYSKKYISQNYPDNKFFEKARIHLHCPEGAVPKDGPSAGITMTTSILSLALNYSIPSTIAMTGEITLTGKILKIGGLKEKIIAAKRSGVNTIIYPDANQADWDIIPDNIKEGLIALPVNWYSDVFDIIFKNMDKSKISTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTH2</accession>
    <name>M7NTH2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_01287</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFB7 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873211.1">
        <property type="nucleotide sequence ID" value="XM_007875020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTH2"/>
    <dbReference type="STRING" id="1069680.M7NTH2"/>
    <dbReference type="GeneID" id="19894984"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01287"/>
    <dbReference type="eggNOG" id="KOG3468">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154847_3_1_1"/>
    <dbReference type="OrthoDB" id="268414at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008698">
        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05676">
        <property type="entry name" value="NDUF_B7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR10582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="83" mass="10094" checksum="4B683219AE955201" modified="2013-05-29" version="1">MADQDKSFFSSETNGSLKKVCRPINLSYRDGCMKLLEELNYCRENTWYLPWKCVEERHAYEKCEYEIFKERVKSLKELEKVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTQ5</accession>
    <name>M7NTQ5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">XPG-I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01356</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873286.1">
        <property type="nucleotide sequence ID" value="XM_007875095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTQ5"/>
    <dbReference type="STRING" id="1069680.M7NTQ5"/>
    <dbReference type="GeneID" id="19895053"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01356"/>
    <dbReference type="eggNOG" id="KOG2519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007575_2_1_1"/>
    <dbReference type="OMA" id="ITWINEQ"/>
    <dbReference type="OrthoDB" id="2959108at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09870">
        <property type="entry name" value="PIN_YEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF75">
        <property type="entry name" value="ENDONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="3">
        <location>
            <begin position="111"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR10657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="65523" checksum="1C99FCAAE40A1580" modified="2013-05-29" version="1">MGVPGLWSFFKEFGESISLAKLACDHYYKDNRVPKGFRIGIDLLIWSYQMRSSHGGQNPELRTLFFRLCRLGYLGILPIFVLDGSKRPLFKRNRKVPKAIFGLSQVIDLIRLFGFPIWYAPGEAEAECALLLKKSIIDAVMSTDVDSFIFGAQKVISDWSVDDESKTSTLSHVSIFDIETVMKKSNISQAGMLLIALISSGDYDSTGIPNCGIKTAISAAKAGFGDTLLSLIKNRLDLTSWKKDLEKYLSTNHGGHFSTRHSFLKLPEDFPNQDIIQFYINPVVSTDLELKRKLRHVVWKWPINVPKLQKFVSIHFSWSDLPGIKRFVRSFAPCYLVSSLKHTDFSKHAEINCSQKSNSMKKINSTYFTNIKEHLKNIENKDEENGIKILCYRKHVSTGYSLEFRISFCPFKLINIDFTSGKQSNKNDIELNDKNVSNFTQITNKEIDLNEKMEIWILDPYLKDFEKHDIIEWKSKTKNNTFKKKLGYDQLGAIESYLLAPSKNRSILGSLELNQNSLKKQNIIPHSLSLNSTSSLTQKTQISQTYKIKTISKSQSSIPSNSSLIQSTLSTLTQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NU72</accession>
    <name>M7NU72_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00973</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872887.1">
        <property type="nucleotide sequence ID" value="XM_007874696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NU72"/>
    <dbReference type="STRING" id="1069680.M7NU72"/>
    <dbReference type="GeneID" id="19894671"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00973"/>
    <dbReference type="eggNOG" id="KOG0252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_46_12_1"/>
    <dbReference type="OMA" id="IMFTNFQ"/>
    <dbReference type="OrthoDB" id="2261376at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="12"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="496" mass="55554" checksum="945C50D5027485D5" modified="2013-05-29" version="1">MKKLAQQKSLLQAIVGGVGLFSDGYLNGVSGVLTTIMGNIYPVEYTIQKKSLLNSMIFVGNVLGMLVFGYMCDKSGRKISLILASSFLVVFSILSSAAYFKGTNDGIIGSLIVYRFFLGIGIGGEYPAGSTTISESAQEMSIKRKHSIFIFLTDFMICMGFMIAAFVAYILTLIFTEKRQEVIWRILLALGAICPFFLLIARLKMGEPDAYKNYAMKKVNIPYKLVIRKYYKRLIFISLVWFIYNFTAYSFGIYFSPLLQSINRQMSLAQIFGWTTFIYLFYIIGSFIGAFMTDYFEPKNVLAFGVFLQGIFGFLMAGLYLKLKDSVIAFIILYALFMAFGEIGPGDNIGNISAKASPTPIRGQFYGICAASGKIGAFVGSYAFNYIIERFGGSESENGNKGPFFIGSALAIISGIISFFFIPKLSHDCVREENEHFKIWLQEQGYDTSKMGLYFPHSNGDLKEIENSEADIEKIDTEKVDYFESAQDSKDYEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUB1</accession>
    <name>M7NUB1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00847</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Required for proper proteasome assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872756.1">
        <property type="nucleotide sequence ID" value="XM_007874565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUB1"/>
    <dbReference type="STRING" id="1069680.M7NUB1"/>
    <dbReference type="GeneID" id="19894545"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00847"/>
    <dbReference type="eggNOG" id="KOG1498">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033860_2_0_1"/>
    <dbReference type="OMA" id="AENEMFK"/>
    <dbReference type="OrthoDB" id="268763at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000070">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040896">
        <property type="entry name" value="RPN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18098">
        <property type="entry name" value="RPN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="234"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="127"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="443" mass="51938" checksum="52C80826BF92BDC3" modified="2013-05-29" version="1">MSHGPLEGPNFDFKEILDSQIPCIKELAKNHLPNALEKISLLEKKTRKASDLSSTSRLLVLIVELCKDANEWTLMCEQVQLMSKRHGQFKKSLVDMIQEAIKALDFVPNLMIKLECIESLRSITEGKIFLEAERVSLTRDLAKIKEQQNNIKEAAELLCELKIETFGSVDKREKTEFILEQIRLCLAKSDYNLASIISRKISIKYFQEEGVEDLKLKYYELLIRIGLYEDNYLEVCKYYKAVYDTPSIIQDESKWKDVLQNIVYFIIISPYGNEQSNLLHHTLADPKLQSLPVHYELIKYFTKIELMRWPKIKEIYGELFRKTSVFDLNDEKGKKRWADLKKRIIEHNIRVVSKYYLRIRLSRLNMLLDLNERETEEYLSNLVTSGVIYARIDRPAQTVSFMKPKNANVILNEWSWNIGTLLEKIEKVRQMILKEEMQAKLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUP9</accession>
    <name>M7NUP9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reticulon-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Endoplasmic reticulum membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872529.1">
        <property type="nucleotide sequence ID" value="XM_007874338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUP9"/>
    <dbReference type="STRING" id="1069680.M7NUP9"/>
    <dbReference type="GeneID" id="19894328"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00630"/>
    <dbReference type="eggNOG" id="ENOG502SA83">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_927867_0_0_1"/>
    <dbReference type="OMA" id="HYVNILR"/>
    <dbReference type="OrthoDB" id="567788at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003388">
        <property type="entry name" value="Reticulon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02453">
        <property type="entry name" value="Reticulon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50845">
        <property type="entry name" value="RETICULON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Reticulon" evidence="7">
        <location>
            <begin position="42"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR11032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="300" mass="34240" checksum="E8AA06B847FFDB09" modified="2013-05-29" version="1">MTSDKNLKLDLDKESSDTCFLSKKNTSNTYDPQSLSKYYLFFSDLFTWKYPRTSGSVLGGVTLLLLLSNTVDIPRLILRTAWIVFASSTVIEITGRSLFKQHSGFISQFAPTSFYSISRKSLNNFIDKTCDIINFALYGIQELLFARKIKHTAIAFIVSWISFVLVQFLSFIHTLLLGVLLAFTVPLFYIKYQKTIDKYFKSIFIISRKYSCALKKHAGKYTEKMAKKLSSDFIKLSTKINNDMNKFKNGFMKNKILLNLKVKKVKSTVLPKTPVSDISTTQEILTEGIEKHDTNVPITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUV8</accession>
    <name>M7NUV8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01037</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TAF9 family. CENP-S/MHF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872950.1">
        <property type="nucleotide sequence ID" value="XM_007874759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUV8"/>
    <dbReference type="STRING" id="1069680.M7NUV8"/>
    <dbReference type="GeneID" id="19894735"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01037"/>
    <dbReference type="eggNOG" id="ENOG502RS0B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100369_2_2_1"/>
    <dbReference type="OMA" id="VTEMVWE"/>
    <dbReference type="OrthoDB" id="1872155at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071821">
        <property type="term" value="C:FANCM-MHF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22919">
        <property type="entry name" value="HFD_CENP-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029003">
        <property type="entry name" value="CENP-S/Mhf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22980:SF0">
        <property type="entry name" value="CENTROMERE PROTEIN S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22980">
        <property type="entry name" value="CORTISTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15630">
        <property type="entry name" value="CENP-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR10891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15640" checksum="31767D5911604C98" modified="2013-05-29" version="1">MTNKSRHVVESVDDEKALQIQALQSAVWYTTGHITDSESLELGVIPSSHFIASLSTLVYSQINTLGEDIESFAKHRGGKVVNVDDVLLCTRRNEGLHDLMVKYAKQHTTASTSEPKLKRKQKENIREAVKQNVKSPTSHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NV43</accession>
    <name>M7NV43_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00598</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the importin beta family. Importin beta-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR10996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872494.1">
        <property type="nucleotide sequence ID" value="XM_007874303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NV43"/>
    <dbReference type="STRING" id="1069680.M7NV43"/>
    <dbReference type="GeneID" id="19894296"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00598"/>
    <dbReference type="eggNOG" id="KOG2023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008136_1_0_1"/>
    <dbReference type="OMA" id="AQEGAMS"/>
    <dbReference type="OrthoDB" id="951172at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010458">
        <property type="term" value="P:exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000028">
        <property type="entry name" value="Transportin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="33"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR10996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="906" mass="102777" checksum="09EC0F1411107670" modified="2013-05-29" version="1">MSNSWKPQIEIFSQLIEILRNSISEDSICRNEAMMHLEEAQKIPDFNKYLANIFLEANKSDISIRSTAGLLLKNNINMFFSQISNDVLMYLKEASFNGLSDSQQLIRSIAGNLITTIIRKGGIINCPEILPKLMQMLESPDISTQEGAFSAMAKICEDSSRELDQEYNGERPLNFMIPKFLSYTDSKNPKIRADAFFCLNQFILTRSQSLFAHIDMFLTKLFQSATDSTPDVRKNVCQALVMLLDIKSDKILPSFNSIVEYMLYCTSDSDENVALEACEFWLAVAEQPELQIPLEQYLDRIVPTLLKGMVYSELDILALGGDEDDTHIVDKPEDIKPQHAKAKIHENQHIYDESSQKIPRLEDDSFNQSDYDYDESEDETYSQWNLRKCSAAAFDVLSTVYHNKLLEISMPYLRQNIFNEDWKIREAGVLSLGALAEGCFKDMEKFLPELFPYLISLLNDPQPLIRQMTCWTLGRYARWAAFLPSEEGRQKYFVTLLEGLLRMVLDNNKSVQKAGCSALANLEEQAGPILIPYLNPILHALVMAFQKYQQRNLLILYDALQTLTNSVGQALNKKEYIDLLMPPLIKKWDSLTDDDRNLFPLLECLSSVTVALGEGFMPFAPPVFSRCISIIHKTLIQLNSYNQDPRLDIPDKNFLVTSLDLLSGLVEGLGTNFEYLIMQAEPPLVQLLSICITDPSPEVRQSSYALLGDLSIFCFHHIKPYIAPLMSELIGQLDLQHESFGVYSNAAWSAGEISLKMGLEMLPYSNPLLNRLIRLLKEPNSLPSVLENCAIAIGRLSLVCPDSVAPNLRNFAKPWCAALMNVHDNEEKDSAFRGLCASISRNPEAMTDVLPDFMSAIARFQKPSPELNDMFSKILRGYKAMLSNWNNIMSTLLPENQQHLRQRYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVA2</accession>
    <name>M7NVA2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">dual-specificity kinase</fullName>
            <ecNumber evidence="1">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_00658</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="1"/>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872558.1">
        <property type="nucleotide sequence ID" value="XM_007874367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVA2"/>
    <dbReference type="STRING" id="1069680.M7NVA2"/>
    <dbReference type="GeneID" id="19894356"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00658"/>
    <dbReference type="eggNOG" id="KOG0671">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_5_16_1"/>
    <dbReference type="OMA" id="RHHIQSF"/>
    <dbReference type="OrthoDB" id="283111at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14134">
        <property type="entry name" value="PKc_CLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000612">
        <property type="entry name" value="Serine/threonine-protein kinase AFC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="116"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR11061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="447" mass="51744" checksum="58C045D70C7A214E" modified="2013-05-29" version="1">MIGEVPGGYGLTESRVAAYGYPEFFTRPPVLYQPTYPPLAPTKMIRRGLSELAPPWLDEERVSLLSRETMSKKQTLKNKEVYVKLIKDLYPTDGVKFDDDDGHYIVIPNSDLTPRYRIIKVLGQGTFGKVIQCYDRLKKDYCAIKVIRSIQKYRDASMIELRVLRTISENDPENLRKCIHMRDCFDYRNHICIVMGLLGMSVFDFLKNNSFIPFPLSHIQHFAYQLFTSVAFLHDLNLIHTDLKPENILLVHAGFRTVPYTKKLGVKVKRLLNNTEIRLIDFGSATFENEYHSSVVSTRHYRAPEIILGMGWSYPCDIWSIGCILIEFFTGEALFQTHDNLEHLSMMEIICGKLEPKFIRQSSKSAQKYFRHSGKLDYPNKDTSPSSRKFVKTMRSLKEIVPSTSPLKTHFLDLLTKIFIYDPNKRITAKEALSHPYFFTPVREDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVL4</accession>
    <name>M7NVL4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphatidylinositol N-acetylglucosaminyltransferase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00361</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872234.1">
        <property type="nucleotide sequence ID" value="XM_007874043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVL4"/>
    <dbReference type="STRING" id="1069680.M7NVL4"/>
    <dbReference type="GeneID" id="19894059"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00361"/>
    <dbReference type="eggNOG" id="KOG3059">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024002_2_0_1"/>
    <dbReference type="OMA" id="STSYHAF"/>
    <dbReference type="OrthoDB" id="196709at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009450">
        <property type="entry name" value="Plno_GlcNAc_GPI2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06432">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016104">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="36999" checksum="2BC1C16CD78C2496" modified="2013-05-29" version="1">MTYSFTRPFGVVKEDMYYKKSAAHFHSKRKKKWRKLLWVKQDYPDNWVDESFLKELERNVNVKVYDFWPLVADSIVLMQHLCSIAIFICAFISIYYQRVSPGVLIGISTGFTICCYILWDLGITKFDYNRNIHDRKEIAKFSILIILMIFCVSPILESLTKSTTSDSIWALAFCLFLANIFFHDYSTAEWANKKFPGSLSTNAGVMASVVLASQLTSYIHAFSLIVFAVELFALFPMFRRYLRQNFSFTIQLILTAFLLIIASILITLEICFALALLFIFSFFFISFVCPLWLISLQKYKSEIHGPWDIAKPKFGNSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVR5</accession>
    <name>M7NVR5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anti-silencing function protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00815</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ASF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872722.1">
        <property type="nucleotide sequence ID" value="XM_007874531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVR5"/>
    <dbReference type="STRING" id="1069680.M7NVR5"/>
    <dbReference type="GeneID" id="19894513"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00815"/>
    <dbReference type="eggNOG" id="KOG3265">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060354_0_1_1"/>
    <dbReference type="OMA" id="DYADQEM"/>
    <dbReference type="OrthoDB" id="29755at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070775">
        <property type="term" value="C:H3 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010698">
        <property type="term" value="F:acetyltransferase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1490:FF:000001">
        <property type="entry name" value="Histone chaperone ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1490">
        <property type="entry name" value="Histone chaperone ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006818">
        <property type="entry name" value="ASF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036747">
        <property type="entry name" value="ASF1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040">
        <property type="entry name" value="ANTI-SILENCING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040:SF0">
        <property type="entry name" value="HISTONE CHAPERONE ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04729">
        <property type="entry name" value="ASF1_hist_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101546">
        <property type="entry name" value="ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR11226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="213" mass="24303" checksum="FCBCD9D45FB65A34" modified="2013-05-29" version="1">MSIVNILSIDILNNPAPFLSPYEFEITFECLESLKNDLEWKLTYVGSATSTLHDQELDSLLVGPIPIGINKFLFQADPPTAELIPKKDILGVTVILLTCAYDSREFVRVGYYVNNELPGVLLRDDGTPDVEKWTVEDVQRNILAEKPRVTRFNIRWDGEGGEEMPPVQDDVEEDEEIYSMEEQFEDFLEETEYDEEAIEIDLEGEETSESNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVX1</accession>
    <name>M7NVX1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_00478</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872363.1">
        <property type="nucleotide sequence ID" value="XM_007874172.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVX1"/>
    <dbReference type="STRING" id="1069680.M7NVX1"/>
    <dbReference type="GeneID" id="19894176"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00478"/>
    <dbReference type="eggNOG" id="KOG1462">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016743_3_0_1"/>
    <dbReference type="OMA" id="NCVINPK"/>
    <dbReference type="OrthoDB" id="10250549at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04198">
        <property type="entry name" value="eIF-2B_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04652">
        <property type="entry name" value="LbH_eIF2B_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="EIF2B subunit epsilon/gamma LbH" evidence="11">
        <location>
            <begin position="326"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR11462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="430" mass="48510" checksum="8876AFCC89A3601B" modified="2013-05-29" version="1">MTTQIKSRQTTGPCGFQAIILAGFGTGLYPLTEANNLPKALLPIANKPMIWYVLKWCEEAGFLSIMVICQTQVESCLSSYLKNVYDGYIRIQVYALSGVDDVLGTADLIRKVHDKIKNDFIILSCDLIMNLPPHEILDFHRIHTPTVTFLLYDISKDGSFLISKDSDRKMFFGINKPDNSLVFVKSASEMNEEFIVRMSMLWKYPRIYVTSTLRDSHLYIFKRWVLDLIVQNERISSIQEDLIPLLVKFQYQSLLLKRYNIKELSSRSYGYNLVSDTLDEKPVRVISYLLPENRYCLRSNTIQAYTDLNRNLSKISIEPRVCITAKMAQKVIIGADSLVGENTKIDERCNVKKSVIGPNCILGKSVTVVNSIIMNNVKIEDGVRLDGCIVCVNSVIGSKSKLKNCCISGGYEVPSGTCARSDNLIVFDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NW34</accession>
    <name>M7NW34_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872233.1">
        <property type="nucleotide sequence ID" value="XM_007874042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NW34"/>
    <dbReference type="STRING" id="1069680.M7NW34"/>
    <dbReference type="GeneID" id="19894058"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00360"/>
    <dbReference type="eggNOG" id="KOG2490">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003655_1_1_1"/>
    <dbReference type="OMA" id="KTFLFGW"/>
    <dbReference type="OrthoDB" id="5376140at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008010">
        <property type="entry name" value="Tatp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317:SF4">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05346">
        <property type="entry name" value="DUF747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="540"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="637" mass="75301" checksum="5C247D9F761C1E6F" modified="2013-05-29" version="1">MSNILEKKMNIRNLTGVSGSKYSNMSLKCRKCKSYEEILDDNESFEKQINNDSEKKSVSGSFERYQRERGYSQNCYACNSSVSPKSRHLIKFNERFSKKNISDDLQKNNSYLNEDFLKLVKNFQLNFLWDHLLMELDISEIDEIKEEREKLMINYLLVPKELEKVLLFGWFICLDTLMYFFTISPLRFIKVLYKIFKNNFLLVWENKIYRDKICRESNIKSSEKIDFLEGFLILGTCVILQRLDASRIYHNIRGQATIKLYVIYNVLEIGDRLLSAFGQDVIESFFSKVSNREGSTKHYYLNLSLYFILALIANVLHTTMLFYQVMTLNVTVNSYSNALLTLLISNQFVEIKGTIFKKFENENMLQMTLADIVERFQLTLMLSIILFRNLIEIYESRFPFSLFPSSFFHFSSYSVFFMITTPVILVMGSEIFVDWLKHMFIIKFNHIQSSIYSRFADVLSDYYISCMNKKKDTRIRQPYFISRKIGLPILPLACLMIRASFKICRIFYSSKLFTDIKILSNDPSLEKIKLFLSKDKIIPIFYGTFIMIILFFCLIVMKLILSTILMKLSYKYYNKVVQDKEEGKEFKITKSSSIGQQEIDEKTRLYLNNVQNKFKDGTQKHTLYTLERYSMVTKRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWB1</accession>
    <name>M7NWB1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00448</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872327.1">
        <property type="nucleotide sequence ID" value="XM_007874136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWB1"/>
    <dbReference type="STRING" id="1069680.M7NWB1"/>
    <dbReference type="GeneID" id="19894146"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00448"/>
    <dbReference type="eggNOG" id="KOG0989">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042324_1_0_1"/>
    <dbReference type="OMA" id="GCQSGSF"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000011">
        <property type="entry name" value="Replication factor C subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000237">
        <property type="entry name" value="replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF20">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="51"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="363" mass="41090" checksum="F86D03EA7D9AC8C4" modified="2013-05-29" version="1">MSIFKQKHRDKEIDKDKMIPWVEKYRPQTLDEVTSQDHTIKVLKKTLHSMNLPHLLFYGSPGTGKTSTILALAKELFGSELIKSRVLELNASDERGISIIREKVKNFARIAIPDGSSEYPYPPYKIIILDEADSMTQDAQAALRRTMETYSRITRFCLICNYITRIIGPLASRCSKFQFKPLSFDNAKTKLEYIASCENVRYDEGVIEKLIELSNGDLRKAITFLQSATRLVNLDSNTNKSLDKNIESISLELITDISGTVPDHIIDNLLSICFSSKKTELLYNSIDQYVSEIISDGYSANQLLSQLHDSIVSNELISNTQKNAMIQIMGETDMRLIDGGSEHLNLLNLAVQISKIYTKNLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWI2</accession>
    <name>M7NWI2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_00524</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.67" evidence="1"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872412.1">
        <property type="nucleotide sequence ID" value="XM_007874221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWI2"/>
    <dbReference type="STRING" id="1069680.M7NWI2"/>
    <dbReference type="GeneID" id="19894222"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00524"/>
    <dbReference type="eggNOG" id="KOG2283">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020105_4_1_1"/>
    <dbReference type="OrthoDB" id="16692at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016314">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051896">
        <property type="term" value="P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14497">
        <property type="entry name" value="PTP_PTEN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051281">
        <property type="entry name" value="Dual-spec_lipid-protein_phosph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305">
        <property type="entry name" value="PHOSPHATASE WITH HOMOLOGY TO TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305:SF81">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatase tensin-type" evidence="4">
        <location>
            <begin position="23"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="113"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR11511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="331" mass="38998" checksum="167AE1537C6EBC07" modified="2013-05-29" version="1">MIDLFKFVLHSIRSRVSFPRTRFYDERNGVSLDLAYITDRIIVMSAPTLLFPKRIYRNNLKDVLRFLEQRHSENWVIFEFCKEGTGYSDKDFLFKVFHYPFPDHEPPPFRIIPEIVDSISKYMNASDDNVVVFHCKAGKGRSGTIACSYLISEEKLTAESALSKFTEARIQKGHGNGITILSQKRYIFYVEKWVSMGKKYQELDIIISQIEIFTENKKIGCKIYGYNDDNRIDCLYTFLPPEIVINNSTMIFTPTIKFISREDICVEIYHQSRFKKNVLKAHCWFNVFFERDAGQTEGIFSVDFENCDYLKTTCRDKSKLFDKFILKWKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWP9</accession>
    <name>M7NWP9_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L44</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_00025</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871876.1">
        <property type="nucleotide sequence ID" value="XM_007873685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWP9"/>
    <dbReference type="STRING" id="1069680.M7NWP9"/>
    <dbReference type="GeneID" id="19893723"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00025"/>
    <dbReference type="eggNOG" id="KOG3464">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114645_2_1_1"/>
    <dbReference type="OMA" id="DILVMTN"/>
    <dbReference type="OrthoDB" id="2967263at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.80:FF:000001">
        <property type="entry name" value="60S ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36A/L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR11581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="106" mass="12488" checksum="F227A589D844B868" modified="2013-05-29" version="1">MVNIPKLRRTFCEAKQCRKHTQHKVTQYKKGKDSLYAQGKRRYDRKQRGYGGQTKQIFRKKAKTTKKVVLKLECTVCKRKKQIPLKRCKHFELGGDKKTKGAALMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWY1</accession>
    <name>M7NWY1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydrofolate reductase</fullName>
            <ecNumber evidence="2">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00209</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872077.1">
        <property type="nucleotide sequence ID" value="XM_007873886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWY1"/>
    <dbReference type="STRING" id="1069680.M7NWY1"/>
    <dbReference type="GeneID" id="19893907"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00209"/>
    <dbReference type="eggNOG" id="KOG1324">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043966_2_1_1"/>
    <dbReference type="OMA" id="QYEFQMW"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046452">
        <property type="term" value="P:dihydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017925">
        <property type="entry name" value="DHFR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069:SF3">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00070">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00075">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="8">
        <location>
            <begin position="6"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="206" mass="23855" checksum="725B637834A74644" modified="2013-05-29" version="1">MNQQKSLTLIVALTTSYGIGRSNSLPWKLKKEMVYFKRVTSFVPAFDSFEWMNVVLMGRKTWESLPLQFRPLKGRINVVISREESLDLGQGIHCARSLDDALELLSCIYSSENPIQVNRIFVIGGAQLYKAAMEHPRLNRIIATIIYKDVNCDVFFPVKFRDQELSSVWKKEEHSHLESWIGSKVPQGKVNEDGFLYEFEMWTRDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWZ5</accession>
    <name>M7NWZ5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872097.1">
        <property type="nucleotide sequence ID" value="XM_007873906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWZ5"/>
    <dbReference type="STRING" id="1069680.M7NWZ5"/>
    <dbReference type="GeneID" id="19893926"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00228"/>
    <dbReference type="eggNOG" id="KOG1471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014001_0_1_1"/>
    <dbReference type="OMA" id="QVMFNDF"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120019">
        <property type="term" value="F:phosphatidylcholine transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032120">
        <property type="term" value="P:ascospore-type prospore membrane formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031322">
        <property type="term" value="P:ascospore-type prospore-specific spindle pole body remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120010">
        <property type="term" value="P:intermembrane phospholipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="25"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="232" mass="27060" checksum="8FF3E4CE4101D5B8" modified="2013-05-29" version="1">MFVECEQWRKDFGVDDIVKTFCYNEKMDIFRYYPQYYHKEDKYGQPIYIEHLGKINLNEMYKITTEERMLQNLVFEYEKFIHHRLPACSRKSGRLIETSCTIMDLKGVGISSISSVYSYVKKATFIGQARYPERMGKFYMINAPWGFSSAFKVIRLLLDAATVNKIYILGTDYKSVLLEQIPEENLPKILGGTCECDGGCEFSDAGPWNDPKWMQSSSNEIDFQKINNNEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7P2A7</accession>
    <name>M7P2A7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_03457</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875547.1">
        <property type="nucleotide sequence ID" value="XM_007877356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P2A7"/>
    <dbReference type="STRING" id="1069680.M7P2A7"/>
    <dbReference type="GeneID" id="19897144"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03457"/>
    <dbReference type="eggNOG" id="KOG2103">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005034_0_1_1"/>
    <dbReference type="OMA" id="SWAEVYH"/>
    <dbReference type="OrthoDB" id="28092at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058545">
        <property type="entry name" value="Beta-prop_EMC1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026895">
        <property type="entry name" value="EMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011678">
        <property type="entry name" value="EMC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25293">
        <property type="entry name" value="Beta-prop_EMC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07774">
        <property type="entry name" value="EMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082715" description="ER membrane protein complex subunit 1" evidence="12">
        <location>
            <begin position="22"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="934"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="domain" description="EMC1 first beta-propeller" evidence="14">
        <location>
            <begin position="44"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 1 C-terminal" evidence="13">
        <location>
            <begin position="751"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR08015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="966" mass="110952" checksum="102D4387D6A5E481" modified="2013-05-29" version="1" fragment="single">MGMSKFLYLFFIFAFLSSIRATFYENDKITFHIPLIGVPLKESIFFHKPISYQNSLIYLATEKNILAAINSKDGSLVWRQKYAENDPINAIKPLDSKIISLSNSSNVRAWNALTGFLIWEETLQNFFLDNRYVIKIFENNITSNKDIILLTSNTIYFLDSNTGSQIWCYGKNVERLPIFLSISNSFVYVVESRVSSNTYFISVSKLDGKTGNKIASNYLFSISKLDDIIYVGSSPLPIIVWRNSSISSSLSIYDFDRNITHIINIEIPFSSVKLYSSEHSNVISPSILLHFTSNSYQKTWASVFSFKSNSSILKLYEISSISATSCFFATIYAFNIFYIHSYINKFGSITIDTYGDKNNSILNTWNISQNQSHSHLEQIISNFFQKKDNSTMIKSVVVMSDGVIYMVKESSILWHREESLSYSIHAEFFQLPQKHIVLIENDSLKKSNFLPSIYIKRIIRHFNKLKEIIKYIVSSIRKKLSKKYKDTSNIQKTRLRKNVFGLKQIIIVITSKGKILALDPFFSGIIIWSNNLGNKFDYKGLWIIKKSKTLNDIPVIAVLGRSFQDMHFWRINGLTGEIINFKKVDNDIKNSFILDHISTNDSNENIIVGITEDKKVKLLYDTSKALPISMLENLSNIYFSTKNLNTLEGYFLDFKNLYANVTWTIDFPSSESIISLSFRNKNEKIASIGRVLGDRSVLYKYLNSHFLAVATGNEEDSKLNIYLIDMVKGMILHTNHYNSVDISKGVEILLTENWIVYQFWIEKPTKGYQIVISELYESETRNKRNKGENSTSIYNIPLPFVISQAYLYPRRIHAFTSVLTRYGITSRDIISYIDSNQIIIIPKKLLDPQRPILTSNKIPSESIKGLIPYDVNLFIDSKIIISCKNEVYGIKNILSSPTLLESTSLILAYGHDIFFTYVTPSNSFDVLNPSFNKFQLLLTIFLLIVGLFLLRSIIKVKLLKKKWLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M7P2Q8</accession>
    <name>M7P2Q8_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_03339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875418.1">
        <property type="nucleotide sequence ID" value="XM_007877227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P2Q8"/>
    <dbReference type="GeneID" id="19897026"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03339"/>
    <dbReference type="HOGENOM" id="CLU_594622_0_0_1"/>
    <dbReference type="OrthoDB" id="5354745at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="460" mass="53449" checksum="36F72915FF1F5A72" modified="2013-05-29" version="1">MTPFKNISTFKSKFLSENQDCLTFLNQESNISRFHKPQTEKQTNNFLKDHRKNFKEKSLNHEKLSEEELIIRLTTPKSLHSSTYSSSPPFIRELSNDLKRLERACGSASSKIQEKTNNFFPLSYSLYNKSQSPENNNTTTIPSNIHDNEDLKISKKDISVKSPNSSEYFMKLSTNVSPIYPLSGHMESYIPLPDLMSDSRASTSCSEESEIKPIHSTPLYKVTRHSKKTAEEKRDIPCKILKEITPHDQDFRHSISHTQLNVESKNIFNKKSNSTIETDNFHKNNIHKDITFFSEDKKPCNITDPTIDKTIKLFGPGAWTTTPQTRTYIKMLSNLDISGEESKHSHISETQNEDHRLTKMLLLLQEELKSTIINVEELELKIQKFEEDSKNKVSISKEDLLKLQFLYEAKKREIKTYVPLCIRYFFFILCIMFLAINILNWALPMHKTYSELPLYQSWPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7P401</accession>
    <name>M7P401_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_03066</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08590.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613290.1">
        <property type="nucleotide sequence ID" value="XM_019757750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P401"/>
    <dbReference type="STRING" id="1069680.M7P401"/>
    <dbReference type="GeneID" id="19896753"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03066"/>
    <dbReference type="HOGENOM" id="CLU_1147590_0_0_1"/>
    <dbReference type="OrthoDB" id="1306014at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20908">
        <property type="entry name" value="SUF4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215:SF0">
        <property type="entry name" value="BUB3-INTERACTING AND GLEBS MOTIF-CONTAINING PROTEIN ZNF207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215">
        <property type="entry name" value="ZINC FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08590.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="329" mass="37129" checksum="987EAF8FD2954DFD" modified="2016-03-16" version="2">MTKKACKRHNQVDLTRPFCYYCERDFDDLKVLTAHQRAKHFKCARCSRKLNTASGLAIHVVQVHKETISTVENAIPGRDSIEVEIYGMEGIPEDVIHSHYNRLMSGVQHRETVPQLESKRQKIETYVDAADIQARLAAHKAAMQQQKQNSHHNSENMIDIKPSISPSGESSQPTTIDIPHQSVMPSVYGIPPQYQNFYQKNTSISSNTYYPIQNHTVPNMPPAFINTQTLNTTCSENNFEESNALSNSDKSFASMDSLTTNTSIPNVSSIKKTSTPLKSNQILVYDDNEMSPEEKKASLPQYKYEFLDEGVETIDTKNIAPLLVNLSYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7P4I8</accession>
    <name>M7P4I8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD synthase</fullName>
            <ecNumber evidence="2">2.7.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">FAD pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_02919</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>FMN + ATP + H(+) = FAD + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.2" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874960.1">
        <property type="nucleotide sequence ID" value="XM_007876769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P4I8"/>
    <dbReference type="STRING" id="1069680.M7P4I8"/>
    <dbReference type="GeneID" id="19896606"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02919"/>
    <dbReference type="eggNOG" id="KOG2644">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056971_0_1_1"/>
    <dbReference type="OMA" id="EEFVQWS"/>
    <dbReference type="OrthoDB" id="270728at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23948">
        <property type="entry name" value="FAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293:SF9">
        <property type="entry name" value="FAD SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293">
        <property type="entry name" value="FAD SYNTHETASE-RELATED FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="13">
        <location>
            <begin position="123"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR08745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="249" mass="28919" checksum="0503FEC9A371F00B" modified="2013-05-29" version="1">MDNPQEITLNNSIPPCNLVSNMNTIISLLSLDLQKNIQISINILRQALDKYGFSGISISFNGGKDALVMLILYFYTLRQYSGENEIKMKKIPAIYIQNPYPFSEIECFVKKCSENYVLDLVYKKSPMKTALKEYLDEHSEIKAILVGSRRNDPGCSMLKHFNPTDFEWPSCIRVHPIIDWCYSNIWEFLRGLNIEYCSLYDEGYTSIGGIQDTFRNPELQLDHDKFKPAYELIDGHKERLGRKYPLKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M7P4T4</accession>
    <name>M7P4T4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GSKIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874641.1">
        <property type="nucleotide sequence ID" value="XM_007876450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P4T4"/>
    <dbReference type="GeneID" id="19896313"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02622"/>
    <dbReference type="HOGENOM" id="CLU_2185084_0_0_1"/>
    <dbReference type="OrthoDB" id="5804279at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2280.10">
        <property type="entry name" value="Hypothetical protein (hspc210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007967">
        <property type="entry name" value="GSKIP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05303">
        <property type="entry name" value="GSKIP_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSKIP" evidence="1">
        <location>
            <begin position="29"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="109" mass="13012" checksum="66527B358FAF4C29" modified="2013-05-29" version="1">METRLFIKEYNSFYKENKEKLKSLCIHLESYTINIVTLEEKEILVEWSILGWTIISVAGKTNGLKKKTYESLETLLKHVSLAFDEQWIGNLLKKLLKYEKRNRILNYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7P636</accession>
    <name>M7P636_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carboxypeptidase C</fullName>
            <ecNumber evidence="2">3.4.16.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02265</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.5" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874254.1">
        <property type="nucleotide sequence ID" value="XM_007876063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P636"/>
    <dbReference type="STRING" id="1069680.M7P636"/>
    <dbReference type="GeneID" id="19895958"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02265"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008523_10_4_1"/>
    <dbReference type="OMA" id="AIANNMS"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082672" description="carboxypeptidase C" evidence="7">
        <location>
            <begin position="24"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="562" mass="65680" checksum="F37D695EBD3B955B" modified="2013-05-29" version="1">MANNILYTFKLLLTFLYIVFVSSETNKQHKNEDEKYSEESNALLSDIPINKLGKYSNIKMFSLIDMLSGFTTEVNDIQKWAEDYYSSIFYDENVDIRAAAREYIQTKLSESNDWKVIERKSFPNHKFHVRKASLSLDTVVQYSGYISFEDKHLYYYFFESRSSPLKDPLVLWLEGGPGCSSLFGLFFTIGPSKYDQKDNYVYYNPWSWNHRSSLIFLDQPVDVGFSYSDNQKVSSTAHASWNFYIFMILFFTAFPQYSHLDFHMAGQSYAGHYLPIFASEIAQYRKYPLNLTDIPASLERLPEINIKSIMIGNGIVDPYNQMPYVYYVGCDSSPWGRMLSKEQCKAMRHSIPKCRYFLELCGEFSSCECTCFSSITACNTFFLEPFLMRSINLYDRRTKSEGDIDEEYKNFSNFINQNKDFFNATSKYIFCNFNVTDRFHKKGELSESVVFFIKLLLINNIKVLIFSGDQDIICNWYGTASWVHKMKWNGSKEFNNLDFRTWSLKRKLGNKLKGTIAGQVKHHSGLTLLRVRDAGHSVGETQPEYNFEMYLRWMQGDYAFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6R3</accession>
    <name>M7P6R3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Methionine aminopeptidase 2</fullName>
            <shortName evidence="9">MAP 2</shortName>
            <shortName evidence="9">MetAP 2</shortName>
            <ecNumber evidence="9">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_02161</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="9"/>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874142.1">
        <property type="nucleotide sequence ID" value="XM_007875951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P6R3"/>
    <dbReference type="STRING" id="1069680.M7P6R3"/>
    <dbReference type="GeneID" id="19895854"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02161"/>
    <dbReference type="eggNOG" id="KOG2775">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015857_7_1_1"/>
    <dbReference type="OMA" id="PFAKRWL"/>
    <dbReference type="OrthoDB" id="7848262at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="11">
        <location>
            <begin position="122"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR09575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="431" mass="48512" checksum="50AEA84AECF81295" modified="2013-05-29" version="1">MANKDHFETDFSKLYDNSSGDLKILSENTKEIDKKGSLLEDIDGIVTDISKVFVTKKKKKKKIKCNSIKQEDPPSIGLTKLYSSGKYPEGEQMDYNNDNLWRVTSEEKRYLELLSCGEYQDFRRAAEVHRQVRKYAQKTIHPGMTMIEIAEMIENSTRMLVEEDGLKAGIGFPTGLSLNNCAAHYTPNAGDNTCLQKDDVMKVDFGVHVNGRIIDSAFTMTFDHKYDKLLEAVKESTNTGVREAGIDVRLCDIGAAIQEVMESYEIELDGNTYQIKPIRNLNGHNITPYIIHGGKSVPIVRGGDQTKMEENEVFAIETFGSTGKGYVKAYGDCSHYAKKANVGHVPLRLARAKHLLSTIERVFGTLPFCRRYLDRIGETKYLLALNNLVNSGIVEAYPPLVDIKGCQTAQYEHTILLRPTRKEVLSRGDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6S6</accession>
    <name>M7P6S6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chromosome segregation in meiosis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02174</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays an important role in the control of DNA replication and the maintenance of replication fork stability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CSM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874157.1">
        <property type="nucleotide sequence ID" value="XM_007875966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P6S6"/>
    <dbReference type="STRING" id="1069680.M7P6S6"/>
    <dbReference type="GeneID" id="19895867"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02174"/>
    <dbReference type="eggNOG" id="KOG3004">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1360929_0_0_1"/>
    <dbReference type="OrthoDB" id="437078at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012923">
        <property type="entry name" value="Csm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040038">
        <property type="entry name" value="TIPIN/Csm3/Swi3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220">
        <property type="entry name" value="TIMELESS INTERACTING-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220:SF11">
        <property type="entry name" value="TIMELESS-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07962">
        <property type="entry name" value="Swi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0236">DNA replication inhibitor</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation in meiosis protein 3" evidence="8">
        <location>
            <begin position="84"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="201" mass="24141" checksum="BF47393A221FD00A" modified="2013-05-29" version="1">MFDNKMETDLFKIDEKDVHIISRKRNYDEGAPVEERDFSKEDKLNPMKRMNDILDDSGVLSDASFSDLGVDEAVFVRTRRPVAKLDDEKLLSPKGLVWIFHNAPQKICWKGRGHEFYDLRRLLLFYQVWAHELFPKARFREILRMIQKHGHSKRIRVARLQWIRMNREELVRSEDASEIRRDELEINEHMFDKKVKEIEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7P761</accession>
    <name>M7P761_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRELI/MSF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873871.1">
        <property type="nucleotide sequence ID" value="XM_007875680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P761"/>
    <dbReference type="STRING" id="1069680.M7P761"/>
    <dbReference type="GeneID" id="19895591"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01897"/>
    <dbReference type="eggNOG" id="KOG3337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067902_3_1_1"/>
    <dbReference type="OMA" id="GYEFFKC"/>
    <dbReference type="OrthoDB" id="341300at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990050">
        <property type="term" value="F:phosphatidic acid transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032048">
        <property type="term" value="P:cardiolipin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120010">
        <property type="term" value="P:intermembrane phospholipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001247">
        <property type="term" value="P:positive regulation of phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="180" mass="21033" checksum="7711A8BDA5BDE406" modified="2013-05-29" version="1">MVKFYKSSYYYEYSWPIVTLAWFLRYPNPYSKHVVSVDVVDRYVDNQGCLRTTRLILKDGKLPKWGAKLFKISQSYILEDSIVNLESNEMHTFIRNLDHTKVMKVVENQTYSVSHNNSCQTFVNVTAQIKSSFGWGFTNKIEKFGVIKFSKNLINSRAGMTHVLKVLRDNGWAKHNNMFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7P8A7</accession>
    <name>M7P8A7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA stability protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the endosulfine family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873324.1">
        <property type="nucleotide sequence ID" value="XM_007875133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P8A7"/>
    <dbReference type="STRING" id="1069680.M7P8A7"/>
    <dbReference type="GeneID" id="19895086"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01389"/>
    <dbReference type="eggNOG" id="KOG4076">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101493_2_1_1"/>
    <dbReference type="OMA" id="TNSNMTQ"/>
    <dbReference type="OrthoDB" id="5949865at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905287">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle involved in cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900237">
        <property type="term" value="P:positive regulation of induction of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902472">
        <property type="term" value="P:regulation of mitotic cytokinesis, division site positioning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006760">
        <property type="entry name" value="Endosulphine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358">
        <property type="entry name" value="ENDOSULFINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358:SF6">
        <property type="entry name" value="ENDOSULFINE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04667">
        <property type="entry name" value="Endosulfine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="132" mass="14437" checksum="B15567F39EA8D79A" modified="2013-05-29" version="1">MLPSQKNKIDLNTLTEEENKLFRLYGKLPQKTDILNNKLKERKYFDSGDYALSKAGKASDVGIINIGSQIPSLETISHHMNLSSYSNSSGGSSISNFSGSPVKESSLLHCSILSQSSSANDVKHDLDTPFND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M7P906</accession>
    <name>M7P906_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873519.1">
        <property type="nucleotide sequence ID" value="XM_007875328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P906"/>
    <dbReference type="GeneID" id="19895263"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01568"/>
    <dbReference type="eggNOG" id="ENOG502SDJV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093897_2_0_1"/>
    <dbReference type="OMA" id="CMSENAD"/>
    <dbReference type="OrthoDB" id="5544375at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012471">
        <property type="entry name" value="DUF1690"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07956">
        <property type="entry name" value="DUF1690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="69"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="163" mass="19080" checksum="B5CF3BFA0ED53703" modified="2013-05-29" version="1">MGKTQSKSSGDVVFQNESRFPLQFSNALVNHLDSKVESDATRAASLEEHIQERVAVEIERLHSRERDILIEIEKELIRKNAKREKAQEKLNSFSLKNEMSKLEENIKGLFQIRMMDEKLLKKKGEVIDCLKENEQKPLNCDETIKAFRKEVDLLKDEFINKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7P9U4</accession>
    <name>M7P9U4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">KRR1 small subunit processome component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">KRR-R motif-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_01345</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Essential for vegetative growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Interacts with snoRNA U3. Interacts with MPP10, KRI1 and with ribosomal proteins RPS1A, RPS4A, RPS4B, RPS8A, RPS8B, RPS11A, RPS11B, RPS13, RPS24, RPS25, RPL4A, RPL7B, RPL8, RPL23, RPL25 and RPL28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the KRR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873274.1">
        <property type="nucleotide sequence ID" value="XM_007875083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P9U4"/>
    <dbReference type="STRING" id="1069680.M7P9U4"/>
    <dbReference type="GeneID" id="19895042"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01345"/>
    <dbReference type="eggNOG" id="KOG2874">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040185_0_2_1"/>
    <dbReference type="OMA" id="TPDIDKW"/>
    <dbReference type="OrthoDB" id="441223at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22393">
        <property type="entry name" value="KH-I_KRR1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22394">
        <property type="entry name" value="KH-I_KRR1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000011">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000014">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048550">
        <property type="entry name" value="KRR1-like_KH1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048548">
        <property type="entry name" value="KRR1-like_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048549">
        <property type="entry name" value="KRR1-like_KH2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="HIV-1 REV BINDING PROTEIN 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581:SF0">
        <property type="entry name" value="KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21800">
        <property type="entry name" value="KH_KRR1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006515">
        <property type="entry name" value="KRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 11" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="K Homology" evidence="13">
        <location>
            <begin position="134"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="284"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="292"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR10645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="322" mass="38268" checksum="22151AC2A4796C34" modified="2013-05-29" version="1">MEDQDQKNIKNISNKSKKYRREKPWDSEEIDHWKIESFVADKDAPSFTDESSFATLFPKYREKYLQEIWPHVTQNLNKYGISCVLDMIVGSMTVKTTRNTRDPYAILKARDLIKLLARSVPFPQAIKIMDDAMACDIIKIGGFLRNKERFVKRRQRILGPNGSTLKALELLTQCYIMVQGSTVSVMGDYKGLKQVRKIVEDCMKNIHPIYHIKELMIKRELEKDPLLKNESWDRFLPHFKKRNVSRRKPKHIKENEYTPFPPPQNPRKIDLQIESGEYFMSKYAKERKKREERKEKQKQVSEKRRKERESAFKPPEDPVYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M7P9Z0</accession>
    <name>M7P9Z0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872745.1">
        <property type="nucleotide sequence ID" value="XM_007874554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P9Z0"/>
    <dbReference type="GeneID" id="19894534"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00836"/>
    <dbReference type="HOGENOM" id="CLU_1723149_0_0_1"/>
    <dbReference type="OrthoDB" id="5419363at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="152" mass="17758" checksum="70B315EBC6D4A4F0" modified="2013-05-29" version="1">MKFLKDSVIIQLSPIKHLAHSDPSKKLKKIMPYERNRKRKAKEKEAISEELSNSNLVIYESKKKKNEGNIKKKSMKNEDLGLCNEGSYTLNSKTKKNNHIESKQNISFSLQEHDTKDNEYDEFIWDIENNISYNVSSDNYSLISSNLDYYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAT1</accession>
    <name>M7PAT1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">ATP synthase subunit d, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_00583</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ATPase d subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR10980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872478.1">
        <property type="nucleotide sequence ID" value="XM_007874287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PAT1"/>
    <dbReference type="STRING" id="1069680.M7PAT1"/>
    <dbReference type="GeneID" id="19894281"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00583"/>
    <dbReference type="eggNOG" id="KOG3366">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080463_0_0_1"/>
    <dbReference type="OMA" id="INWAGIT"/>
    <dbReference type="OrthoDB" id="35799at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008689">
        <property type="entry name" value="ATP_synth_F0_dsu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036228">
        <property type="entry name" value="ATP_synth_F0_dsu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12700">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05873">
        <property type="entry name" value="Mt_ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005514">
        <property type="entry name" value="ATPase_F0_D_mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161065">
        <property type="entry name" value="ATP synthase D chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0138">CF(0)</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR10980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="171" mass="19618" checksum="C531B0B5A351E43F" modified="2013-05-29" version="1">MAYAAAKINWIKLLSSYGLSSSVISSLSTFHQWSLNTRAKIGILEEQLQNIDFSYYRSILKNKSLVNQIEKELKAFRPVKYQVDPQIKAIQQFETKAIENATKISENAKKELTELEMTLSNIQQARPIDELTVEDVLTACPEIEKRVEDMVKQEKWSVPGYKEKFGNLAIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M7PB44</accession>
    <name>M7PB44_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872602.1">
        <property type="nucleotide sequence ID" value="XM_007874411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PB44"/>
    <dbReference type="GeneID" id="19894401"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00703"/>
    <dbReference type="eggNOG" id="KOG4173">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055660_1_0_1"/>
    <dbReference type="OMA" id="YESRHAN"/>
    <dbReference type="OrthoDB" id="18440at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039258">
        <property type="entry name" value="ZNF511"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21354">
        <property type="entry name" value="ZINC FINGER PROTEIN 511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21354:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="231" mass="27239" checksum="A123FC9EA2084A57" modified="2013-05-29" version="1">MKRGLTISIDNKVFLENQNEEPSDIYEASLASNKLKKLEFNESEETVVERAKPVITCHFPTECMHQPSSFMSFSAYEAHYQKQHCNVCFECRKVFPSLRMMDLHISEVHDPIFCLKKEKGERIFKCFIENCQELFINVKKRKKHLMREHFYPKAFSFLDNNQYEYHFDVIYTGISSKDTSLLVSKKNVKKRLKPENLEKMDQDFEIEKLVNKMTSTRLVPSSIRFGGGRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7PBD6</accession>
    <name>M7PBD6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872696.1">
        <property type="nucleotide sequence ID" value="XM_007874505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PBD6"/>
    <dbReference type="STRING" id="1069680.M7PBD6"/>
    <dbReference type="GeneID" id="19894490"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00792"/>
    <dbReference type="eggNOG" id="KOG1605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020262_4_0_1"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009651">
        <property type="term" value="P:response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000043">
        <property type="entry name" value="General stress response phosphoprotein phosphatase Psr1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="1">
        <location>
            <begin position="160"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="335" mass="38347" checksum="54B7236D2C0B1031" modified="2013-05-29" version="1">MSTESIEQFSRGLTYKEKKKKSRLRFSRNRLSRMFLHLFVCCVVPSEHFLDIEKQGNKKNKEVNTLDLELEEENDTKNAFLENQLDISKVLTNRNSISIDEEKMDILLGNYGTREAEINYSIKKPLFLDTSDNADLSHSITDSLGPSVHSKWLLGPVLEADKGKKCLVLDLDETLVHSSFKVIHQADFIIPVKIDSTYHNVYVIKRPGVDSFMKRMGELFEIVVFTASLSKYADPVLDMLDIHHVVKHRLFRESCFNHQGNYVKNLSQLGRELKNVLIIDNSPASYVFHPTHAVPISSWFNDSHDTELLDLIPFLEDLTTVPDVTTVLDLGLHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7PBU7</accession>
    <name>M7PBU7_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit tim17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_00374</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872247.1">
        <property type="nucleotide sequence ID" value="XM_007874056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PBU7"/>
    <dbReference type="STRING" id="1069680.M7PBU7"/>
    <dbReference type="GeneID" id="19894072"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00374"/>
    <dbReference type="eggNOG" id="KOG1652">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087811_3_0_1"/>
    <dbReference type="OMA" id="IMFTRIS"/>
    <dbReference type="OrthoDB" id="2261329at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485:SF0">
        <property type="entry name" value="AT05822P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR11345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="158" mass="16840" checksum="05C08C28427DE42E" modified="2013-05-29" version="1">MKEMSYYDHSRDPCPYVILSDFGGAFAMGAIGGGLWHSVKGFRNSPSGEKLIGAISAVKARAPVLGGNFGVWGGVFSSFDCAVKSIRKKEDSWNAIIAGFLTGGSLALRGDIRSIRNSAIGCACLLAIFEGIGIAFNRIMAEQNRPIQPQIPETIRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7PC22</accession>
    <name>M7PC22_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_03468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875556.1">
        <property type="nucleotide sequence ID" value="XM_007877365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PC22"/>
    <dbReference type="STRING" id="1069680.M7PC22"/>
    <dbReference type="GeneID" id="19897155"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03468"/>
    <dbReference type="eggNOG" id="KOG1437">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_444182_0_0_1"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF125">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YLR001C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="237"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="380"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="615" mass="71035" checksum="6729E0D1A370ED06" modified="2013-05-29" version="1">MLLLIETFKRLNSIEYTYLRSRYGISDLKMLILNHLQTNNVIYKCDVIDKIASKSDANGLLNIVKNRTGFYVNEYKIVQYDIITKNGVIHKIDNLMFPGYLEFTPIKYLYGTDTTKFADEILVTGLIDLVNNKSIEQVILAPIDSSFYFDIDMKKIRCIQEIKYHFIYNWFDIDTLEGQKLLTTKMKEKLLGGKNQKIKISRKNGEIWLNDRSMILGKSLVIGKTKIYRIDSELVPPFSFPATAAPIFHISISMEYLYNTKMDILLRNKESLTYFVPTNSAWKDLGLVKDYLTLDSSKDILKEVLINTIFNEVLYFDELLLLNKTIFTLGGASATIQKYPTGFSIISKNKSCKFQIEEHDILLENGVAHTVSKVFIPSTLNITPQHLFSTKHVSLFPQTIESSDLFYLLNPQEKFTILAPIDSAWRTIKNMVRDNSTLQEIVKLHLLPPQLNNSDFLKDVYPRPSLHKDGIKIGAVKIDGSLYNINFYSSKNCYQQINILGEGKTTFHGQILIIDRVLDPKCLLSTSYTYIFQIFFLIMVIFIIFCFFIKKIFHKNSFNYIIAALNNRFHFYNRHLLYHSGCNTQDPDEGLPILHFNYLSKRSLFGLTLSRALTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7PC69</accession>
    <name>M7PC69_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Geranylgeranyl transferase type-2 subunit beta</fullName>
            <ecNumber evidence="3 11">2.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_00508</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="3 11"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872396.1">
        <property type="nucleotide sequence ID" value="XM_007874205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PC69"/>
    <dbReference type="STRING" id="1069680.M7PC69"/>
    <dbReference type="GeneID" id="19894206"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00508"/>
    <dbReference type="eggNOG" id="KOG0366">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028946_3_0_1"/>
    <dbReference type="OMA" id="VKRCQCP"/>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170069">
        <property type="term" value="C:geranylgeranyltransferase-III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000012">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="12">
        <location>
            <begin position="4"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR11495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="317" mass="36406" checksum="E25F22539C760C2D" modified="2013-05-29" version="1">MLDFLIDKHIKYILSFNERKLTEYWETESRKLQSINWAVNTLFVLGRKDLIPRDDILDFVMLCKYEDDSIEAFGESSCTDPHLLNTFYAVQVLAVCDALDRINFDKIAKYISSLQDLETGAFKGYFWNEIDTRFSYSAVCCLGIIDRLDAIDIEKVVKWILKCQNLDGGFGQVPGAESHAGHVLSCIGTLSVLKRLDVIDIDLIGLWLSERQVLNGGLNGRPEKLEDVCYSWWVFSSLVMINRSHWINNEYLINFILSCQDFKNGGISERPKMQPDMFHTCFAILSLSILKYPGLLEINPVYFLPVEVVQKLKMNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCA5</accession>
    <name>M7PCA5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_03547</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875640.1">
        <property type="nucleotide sequence ID" value="XM_007877449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCA5"/>
    <dbReference type="STRING" id="1069680.M7PCA5"/>
    <dbReference type="GeneID" id="19897234"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03547"/>
    <dbReference type="eggNOG" id="KOG0652">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_2_4_1"/>
    <dbReference type="OMA" id="NKISHEH"/>
    <dbReference type="OrthoDB" id="9443236at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045899">
        <property type="term" value="P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000009">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000076">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="179"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR08109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="399" mass="44784" checksum="D161E29054198E3E" modified="2013-05-29" version="1">MRNIYYYLINTIQVMRSEYQRLIHEQKTMEEKIKDNEEKIKNNKQLPYLVGNVIEVLDMDPTTETEEGANVDLDATRKGKSAVIKTSTRQTIFLPLIGLIDSENLKPGDLIGVNKDSYLILDTLPPEYDSRVKAMEVDEKPMETYSDIGGLDKQIEELVEAVVLPMKQADKFKSLGIRPPKGALMYGPPGTGKTLLARACAAQTNATFLKLAAPQLVQMFIGDGAKLVRDAFSLAKEKAPAIIFIDELDAIGTKRFDSDKSGDREVQRTMLELLNQLDGFSSDERVKVLAATNRVDTLDPALLRSGRLDRKIEFPLPNEEARAGILQIHSRKMTIDNQINWNELARSTDEYNGAMLKSVCVEAGMIALRQGETKINHEHFADAVNEVMMRKKTISNFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCC8</accession>
    <name>M7PCC8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thymidylate synthase</fullName>
            <ecNumber evidence="2">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_03567</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875660.1">
        <property type="nucleotide sequence ID" value="XM_007877469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCC8"/>
    <dbReference type="STRING" id="1069680.M7PCC8"/>
    <dbReference type="GeneID" id="19897254"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03567"/>
    <dbReference type="eggNOG" id="KOG0673">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021669_0_2_1"/>
    <dbReference type="OMA" id="AYGRFWR"/>
    <dbReference type="OrthoDB" id="766at2759"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.572.10:FF:000002">
        <property type="entry name" value="Possible thymidylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002497">
        <property type="entry name" value="PRK01827.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548:SF2">
        <property type="entry name" value="THYMIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="THYMIDYLATE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate synthase/dCMP hydroxymethylase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="297" mass="34156" checksum="0B26521050096DA8" modified="2013-05-29" version="1">MVNAEEQQYLNLVQHIINHGEDRPDRTGTGTLSIFAPSPLKFSLRNKTLPLLTTKRVFIRGVIEELLWFIRGETDSLKLKEKNIHIWDANGSREYLDSIGLTKRQEGDLGPIYGFQWRHFGAEYIDCKTNYIGQGVDQLANIIQKIRTSPYDRRLILSAWNPSDLEKMALPPCHIFCQFYVHIPSNSHRPELSCQLYQRSCDMGLGVPFNIASYALLTCMIAHVCSLDPGDFIHVMGDCHIYKNHIAALQQQLTRSPRPFPTLSLNRSITNIEDFTLDDFIIQNYHPYETIKMKMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCM5</accession>
    <name>M7PCM5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ran-specific GTPase-activating protein 30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875467.1">
        <property type="nucleotide sequence ID" value="XM_007877276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCM5"/>
    <dbReference type="STRING" id="1069680.M7PCM5"/>
    <dbReference type="GeneID" id="19897070"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03383"/>
    <dbReference type="eggNOG" id="ENOG502R7I3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014536_1_0_1"/>
    <dbReference type="OMA" id="WDPYNES"/>
    <dbReference type="OrthoDB" id="512915at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008812">
        <property type="entry name" value="Ran_GTP-bd-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31010:SF2">
        <property type="entry name" value="RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31010">
        <property type="entry name" value="RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN 30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05508">
        <property type="entry name" value="Ran-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="582" mass="65343" checksum="97E4749C5945E6DC" modified="2013-05-29" version="1">MDDFLAKVSIAAATFAIRSGVSIAGGIALRQVSRYIKDMPSQAQRQMLDSLKKQLEQKIRIVTPAIDLIEIISARGNTSLGSTVHLTNSLRRDINAFAKRVSDAADEQEISKHINKNNMGVIMTDMKNLLSRIEDAVPLISLALTTSGANISSSLPNTVSPSRLLQASSFLISADSLFCKTPYPKFQQVGPVFILKLYTIFSGSARVAHMISTSDITWKEEHAKCLVSIIRVDLNDYSESKSDLARKRANEYAYELQVIEDLNDGRYHEEIEKKRVKKNKDGHIYGSKRNIPIHLISRLFFNASGRLLNIEEAKTPVLVLKLNHALSPPRKLLESIRDDNTEDDGNQGNVDEESFYDKINDPENIEWIAFEIWNDDVDDEDKSQDDTGSNVSDISESSSENDEYDNIYENVNNGESCNNDEKYLKNMSSSDNQKASKETINDKNKTLKSEEQIDEFSAALKALDINVESTNEILELQKNSSTNLATLSLLEYIIRLTALQTSEQTSLLSVTDERISLFLRDDNHNSRTRERTGALEYGETPHSSPSSIKLEKDSIKSQENRRIRKDLLLDSRNSPRSPLSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCP1</accession>
    <name>M7PCP1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoenolpyruvate carboxykinase (ATP)</fullName>
            <ecNumber evidence="3">4.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_03397</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>oxaloacetate + ATP = phosphoenolpyruvate + ADP + CO2</text>
            <dbReference type="Rhea" id="RHEA:18617"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.49" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875482.1">
        <property type="nucleotide sequence ID" value="XM_007877291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCP1"/>
    <dbReference type="STRING" id="1069680.M7PCP1"/>
    <dbReference type="GeneID" id="19897084"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03397"/>
    <dbReference type="eggNOG" id="ENOG502QQI5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018247_2_0_1"/>
    <dbReference type="OMA" id="MRYAGEM"/>
    <dbReference type="OrthoDB" id="184182at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00484">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.8.10:FF:000001">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00453">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015994">
        <property type="entry name" value="PEPCK_ATP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00224">
        <property type="entry name" value="pckA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006820">
        <property type="entry name" value="PRK09344.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006821">
        <property type="entry name" value="PRK09344.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006294">
        <property type="entry name" value="PEP_crbxkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00532">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR08229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="541" mass="61021" checksum="ED90F1D754A538BF" modified="2013-05-29" version="1">MSSIKENLEIQKELMETVNIDYNKVSIQYNPSVASLYEDALIYESSSAITSTGALAAFSGEKTGRSPKDKRIVDHPQSNEKVWWGPVNSKISHTVWLINRERAVDYLNTLKRIYVFDGYAGADKRYRIKVRVICARPYHCLFMKNMLIDQTEDDDFYQKPDFVIYNAGSFPANRYTVGMTSRTSVAINLEDREMIILGTEYAGEMKKGILTVMFYLQPVLYDVLPLHSSANEGKNGDVSVFFGLSGTGKTTLSADSSRYLIGDDEHCWSDTGIFNIEGGCYAKCVDLSQEKEPEIFNAIRFGSVLENVVFDPRTRVVDYTNISITENTRCAYPIEYIPNAKIPGISSGHPKNIILLTCDAHAILPPVSKLTNDQIIYNFISGYTSKISGTEDGIIEPQPAFSACFGEPFLVLHPMEYAIMLSERVKKHNADAWLINTGWVGQSFSKGGERCPLKYTRIILNAIHSGELAKAEYQNFPVFNLQIPKHIEGIPPEILNPFESWRGTKEEFYENLYKLAELFIKNFEKYKDMATQNVLDAGPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M7PD63</accession>
    <name>M7PD63_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mtf2-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875297.1">
        <property type="nucleotide sequence ID" value="XM_007877106.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PD63"/>
    <dbReference type="STRING" id="1069680.M7PD63"/>
    <dbReference type="GeneID" id="19896918"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03231"/>
    <dbReference type="eggNOG" id="ENOG502S7AT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_963519_0_0_1"/>
    <dbReference type="OrthoDB" id="2444174at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043837">
        <property type="entry name" value="Mtf2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040009">
        <property type="entry name" value="Mtf2/C5D6.12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39468">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39468:SF1">
        <property type="entry name" value="MTF2-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19189">
        <property type="entry name" value="Mtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mtf2-like C-terminal" evidence="1">
        <location>
            <begin position="107"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="289" mass="34358" checksum="BCB3C59CEDE5ACCF" modified="2013-05-29" version="1">MKLLNTFGYKAFSMAFYGVLYDFMRMKRKEFERFIIYRTNCSLYDYWLIKSSGNAILCNFIPRTGFFSEKRYLNSILKPLVPSGFQKNSFSDKSQKNINDTELQLCFKKIEETMLNMRTDLELHNFVEKSIFEPFKKQLSEGKINKRLSKSIISRLYSQLLQKAMEIFRLNFLDYVSVATIFERIKELGPESFVLGCSSNVYNEMLLARWEGWNDIIEIENLLTEMKINSVPRTEKTLKIFEKIRSDIENMELQKHLLNDTLLSNNNMAYRERLDAIYDEILHEIFLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7PDP2</accession>
    <name>M7PDP2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor Cactin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_03065</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CACTIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875121.1">
        <property type="nucleotide sequence ID" value="XM_007876930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PDP2"/>
    <dbReference type="STRING" id="1069680.M7PDP2"/>
    <dbReference type="GeneID" id="19896752"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03065"/>
    <dbReference type="eggNOG" id="KOG2370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011759_2_1_1"/>
    <dbReference type="OMA" id="HIDFWND"/>
    <dbReference type="OrthoDB" id="265955at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019134">
        <property type="entry name" value="Cactin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018816">
        <property type="entry name" value="Cactin_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737">
        <property type="entry name" value="POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737:SF4">
        <property type="entry name" value="SPLICING FACTOR CACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10312">
        <property type="entry name" value="Cactin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09732">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Splicing factor cactin central" evidence="4">
        <location>
            <begin position="39"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Splicing factor Cactin C-terminal" evidence="3">
        <location>
            <begin position="392"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="527" mass="62602" checksum="0D6BC5DF9B2A555D" modified="2013-05-29" version="1">MKEHRSRSRSPTTSYSNNKRVKSIGRIRRIPYGPLTEDYKKILVWQSKEGEFILSQAKKRAELRVQYGRETPIDILAVHLRIIDKTEDFCEEQPEHAEVVLKDPVVFLETLNLEALEELEKEINQYLKWETEEENIEFWRSIDVIRRDQILKLKSKGHDNGEFRLSRTIEAQVDSLLKGKTKEELEILGAQIDEKLQGETLIDVDYWEKMKECLIVWKSRVILKELHKKILHQRREALKNQQLHEGRMDREALKNIYNKKILDPNYCFIKDDKTFIAQVTELPDIYQETMDPEPLSILEYEDKKSYRIHESAYQDQLISDRDRILRSGFVPIKMVKNDIPISKNLPNTDDITDDSFSTITNVLYEREASKGENDDEELFNVEEEIIQTTPSWADTYRPRKPKFFNRVQTGYDWNRYNQVHYDANNPPPKVIQGYKFNIFYPDLIDKTKAPTYRIERNKKKNSGQDLFSEDETCLIRFIAGPPYEDIAFRIIDKDWDYSAKRERGFKSSFDKGVLHLSFQFKKVFYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7PEK1</accession>
    <name>M7PEK1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Armadillo-like helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02677</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874700.1">
        <property type="nucleotide sequence ID" value="XM_007876509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PEK1"/>
    <dbReference type="STRING" id="1069680.M7PEK1"/>
    <dbReference type="GeneID" id="19896368"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02677"/>
    <dbReference type="eggNOG" id="KOG4654">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029861_1_1_1"/>
    <dbReference type="OMA" id="YEATHLN"/>
    <dbReference type="OrthoDB" id="2012278at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039868">
        <property type="entry name" value="ARMD3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013636">
        <property type="entry name" value="ARMH3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608:SF3">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08427">
        <property type="entry name" value="ARMH3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01158">
        <property type="entry name" value="DUF1741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Armadillo-like helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="595" mass="69723" checksum="0D11FCEC6FE5A4EE" modified="2013-05-29" version="1">MNNKDKLIKRNFQPKILAQYERIFNKTSDEILEDQFFKDLYILRSDLRELESILEELSPDDLLKLQNNIRNLFKKGVLIMKDMDPLRIENALDTLKVFLRIILQKKYNNFTSDVVHIISGLDNIDKIFMDFVISLETLIQKETSVILRTKALSLSLCTVCHGFNSNIISYFQYRDFFPSIIKYITDPSTFSTAFLAFLFLGVLANNKKFESQNLYQTRLSDFVDNNAMQLIIDIISRICIECKNEYIYLQNNESDNIWNITNLLTYFNDIFFTSNNHKSASLDTTIILSENGFSKLPSCKAAILLPIYDFINVNKAFCYIFITFKSPTNNSETESPFSQFISFTSYLLEYQSQSLRASYYARLALLIIHILIDDDGCFDSLVNDANSSIVYLCRQKHPFLPLIKTKRILLLAIFDALISSLDHNLKRNLDIEKYILQIRILLNIISSLEKRKCRLEYHWQEVWKFFMHFIMFLLANSEILKQNSHIEELVLISFNFISLCITRGENFLLEFKDFEDLIYKLVQNGDIIRNFIKIYKVNAASAKTILLISEYYENLLKKYKSHELSPKKVMAIIKEGYGKYRIYYSLQGNKRTGFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7PFP3</accession>
    <name>M7PFP3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cofilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Actin-depolymerizing factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02593</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874608.1">
        <property type="nucleotide sequence ID" value="XM_007876417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PFP3"/>
    <dbReference type="STRING" id="1069680.M7PFP3"/>
    <dbReference type="GeneID" id="19896285"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02593"/>
    <dbReference type="eggNOG" id="KOG1735">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094004_3_2_1"/>
    <dbReference type="OMA" id="ITFYSWS"/>
    <dbReference type="OrthoDB" id="10249245at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="5"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="141" mass="16218" checksum="F21161248CDF2B5F" modified="2013-05-29" version="1">MSKSGVQVSDECLESFHQLKHGKSIKYIIFSINDGKTHIIVEKTSKDVDYEEFIKDLPENDCRYAVYDFEYELKGEGRRKKICFFVWSPDVSPIKSKMLYASSKDALRRALSGISIEIQATDFSEIVYESVIEKVCRRSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7PG80</accession>
    <name>M7PG80_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02411</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874417.1">
        <property type="nucleotide sequence ID" value="XM_007876226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PG80"/>
    <dbReference type="GeneID" id="19896104"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02411"/>
    <dbReference type="HOGENOM" id="CLU_953512_0_0_1"/>
    <dbReference type="OrthoDB" id="5417496at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="6">
        <location>
            <begin position="180"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="292" mass="33440" checksum="04745FB75EADFF01" modified="2013-05-29" version="1">MKNIIFITFAGYILVFFKFIDTIYAAPNYISDDYKEHKNKIYQINNHFSDASSLYKSNDNLNYQKKSDQKESGLYHPRSQFKDTCKSVTLKAKSEDTKKCVLDKLKKTRCVDTDILCLCDSKASHRVIQDCSEFPKYDLTFGIYFDKLCFSAALELDCISPPDPSFPTVICKDLFEGSGLDENARNCMRKAVKHSMCKNISYISCLCDSRSFSYEISECIKDPSFGKKVGTFLNTLCRTPSLLPGCSHSQFLPQVIENEENTGERLYKIKMKEIIFLMLGITIPISLRLMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7PHJ6</accession>
    <name>M7PHJ6_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isocitrate dehydrogenase, NAD-dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01688</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873651.1">
        <property type="nucleotide sequence ID" value="XM_007875460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PHJ6"/>
    <dbReference type="STRING" id="1069680.M7PHJ6"/>
    <dbReference type="GeneID" id="19895382"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01688"/>
    <dbReference type="eggNOG" id="KOG0785">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_0_1"/>
    <dbReference type="OMA" id="WVFFREN"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF34">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="3">
        <location>
            <begin position="46"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR09929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="273" mass="30306" checksum="095BAC47C9A9E6D2" modified="2013-05-29" version="1">MRILSNFVFSRYNYSSFSIKKARFYSTGNYVKGSYKGKPNSSGLYPVTLISGDGIGPEISTSVQKIFEAAKVPIKWEPVDVTPVFVNGKMTIPEATIESIHRNTVALKGPLATPIGKGHVSLNLTLRRTFSLFANVRPCRSIAGCKTAYDNVDIVLIRENTEGEYSGIEHMLVDGVVQSIKLITRDACEKVLRFAFQYAQSIGRKKVTAVHKASIMKITDGLFVKTAYDISKEYPDIELNTERIDSSCLKIVSNPTPYNDRVLVMPNLYGGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7PHR8</accession>
    <name>M7PHR8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UNC-45/Cro1/She4 central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01761</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873726.1">
        <property type="nucleotide sequence ID" value="XM_007875535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PHR8"/>
    <dbReference type="STRING" id="1069680.M7PHR8"/>
    <dbReference type="GeneID" id="19895455"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01761"/>
    <dbReference type="eggNOG" id="KOG4500">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_513004_0_0_1"/>
    <dbReference type="OMA" id="FIIMESS"/>
    <dbReference type="OrthoDB" id="26149at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040144">
        <property type="entry name" value="RAP1GDS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10957">
        <property type="entry name" value="RAP1 GTPASE-GDP DISSOCIATION STIMULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ARM" evidence="7">
        <location>
            <begin position="317"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="547" mass="63170" checksum="24BC0843EE382BC1" modified="2013-05-29" version="1">MSSPCIIDELISLEELEKLYKKCLESTEKCDIIEDLVKNICSIGDFSRELENREYIGKTYTNFMFSIMKDALNIDKRCVFQSLRVIGNCCIDHVKNRKRVLELCGEDILMDFLEHEDLSIYTVSLTSLLNLCMDSDEATEILNRKNAVSRILKTTNFHTNFDILARIIGWLMSKEEKHYDPNCFIGFLSVVQLCPNNVADIFSIILSFLPQNDIQLLLVQSEKLYDLLQYFYRMVPCQEHFNSENKGLISMLINLFGEIAANSDFSEYILNNELIMDMLLKHLEIDSFYILILCSCVMLGNLARTDKTCIYFVHELKLYEKLINIINFSDDPKVIYSSSGFLKNLSIPKNNKSIIGEAGGIKLCTKLFTFDSVKPILYIAVSILRQLIIDNGKNASFFVDSGIFMQLLELRRRTDDHFIIMESSRIVSTMIRTINLFKLFDIEKKMLLYPDFENIFKDMIVQTQYPVIRTEAIFALALISRFYGSEFKKIVFNLLQDEVILNTLIELGKTGTKDLRDNLRVLLFSINSEFQNESINAAFLLLSQCTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7PHV2</accession>
    <name>M7PHV2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome c oxidase assembly factor 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PET191 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873761.1">
        <property type="nucleotide sequence ID" value="XM_007875570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PHV2"/>
    <dbReference type="STRING" id="1069680.M7PHV2"/>
    <dbReference type="GeneID" id="19895487"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01793"/>
    <dbReference type="eggNOG" id="KOG4114">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138069_3_1_1"/>
    <dbReference type="OMA" id="KKTPKEC"/>
    <dbReference type="OrthoDB" id="282149at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018793">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_Pet191"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10203">
        <property type="entry name" value="Pet191_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8539" checksum="872580E4F31EE875" modified="2013-05-29" version="1">MPSSCNDIRKALALCISNSDCMKNGNSAKECLSNSELLEFVPLQCHLLKRSLYNCKRGMLDMRKRFRGNASIGIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7PIG4</accession>
    <name>M7PIG4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_01513</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873454.1">
        <property type="nucleotide sequence ID" value="XM_007875263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PIG4"/>
    <dbReference type="STRING" id="1069680.M7PIG4"/>
    <dbReference type="GeneID" id="19895208"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01513"/>
    <dbReference type="eggNOG" id="KOG0600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_326545_0_0_1"/>
    <dbReference type="OMA" id="MQHFDQN"/>
    <dbReference type="OrthoDB" id="204883at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008024">
        <property type="term" value="C:cyclin/CDK positive transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07840">
        <property type="entry name" value="STKc_CDK9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000440">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000270">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF546">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="548"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="110"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="277"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="832"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="577"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR10244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="882" mass="103502" checksum="FFA629CCDB3F9107" modified="2013-05-29" version="1">MRFKNMGKIGYEEDGYRKRWKERRLTDIFSKMENYRLKKTMQEETSYKHYFYEKEGIIDKKEIERDSGRNRKRSVSPYHKECSKKISRKSHSINIHDKTYVEKRKETFYKRRSPSENISRGLSPFGLNDKRYNSRSPGPINVSERRYVDNLSRSRSNSLERYSKSPKYISLKQESNYSPEYLKDRHFYHKHKNYFLPSLEDKKSDYQKTSNHINKKGHQYSLSFSASSYSHSSYKSNHETNHHNSRFTSRENYKNNLYASHHRDDSGTSYLSSYMADSHEKHRDANDLKNPRYRYSNSGDPCHNSSFSNEFDKNSKETHVLYESPDSYTESSYATTNTHKYKDISKNSYYLHDTENSGNYTQSSEKSNKKLHDTDELFNRNSSKIMDFKKDVIKKQDDTIDPHFSENIKHSMTPIISFKLSNTKNTLSTSRIYLDNTSSLNETSYSHNNKTQESKTSLTMENTQNEFKLSKRSLDFNDTLENDENLNSSLMKKSRSSENIPIRDLENNINYSNDIHQHSEDFQTQGNISIKMPIAKITIMDSKEGFVYERIGQVGEGTYGKVYKARNRITNELVALKKIRMEYEKNGFPITAMREIKLLQSLKHPNVVCLLEMMVEKSTVYMVFEYMDHDLSGVLSNPNFQFELSHAKHLCKQMLDGLEYLHHRGVLHRDIKGSNILLDNFGQLKLADFGLARYYHKKRDTADYTNRVITLWFRPPELLLGATAYGPAVDIWSAGCIMIELFTRKPLFPGHDEIHQLELIYDMMGTPTHENWPTVDQLPWFELLKPSEKKIGKFYDRYSSILSPAALNLLSNILALDPSKRPTATDALKHTFFTQEEPKPEPPLGLGNMKGDWHEYESKRRRKKLREDKEANENMETENMTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7PIR9</accession>
    <name>M7PIR9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">XPG N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01597</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPG/RAD2 endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873554.1">
        <property type="nucleotide sequence ID" value="XM_007875363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PIR9"/>
    <dbReference type="STRING" id="1069680.M7PIR9"/>
    <dbReference type="GeneID" id="19895292"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01597"/>
    <dbReference type="eggNOG" id="ENOG502QVHA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_378548_0_0_1"/>
    <dbReference type="OMA" id="RFYQTKV"/>
    <dbReference type="OrthoDB" id="17262at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09902">
        <property type="entry name" value="H3TH_MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09858">
        <property type="entry name" value="PIN_MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022039">
        <property type="entry name" value="MKT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037314">
        <property type="entry name" value="MKT1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022040">
        <property type="entry name" value="MKT1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF32">
        <property type="entry name" value="POST-TRANSCRIPTIONAL REGULATOR MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12246">
        <property type="entry name" value="MKT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12247">
        <property type="entry name" value="MKT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Post-transcriptional regulator MKT1 N-terminal" evidence="5">
        <location>
            <begin position="311"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Post-transcriptional regulator MKT1 C-terminal" evidence="4">
        <location>
            <begin position="483"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="722" mass="84105" checksum="55C184BF03B3F9A7" modified="2013-05-29" version="1">MPIKTIDSYTEEYKLFNYQPLSVLKDCRIGIEASYYLKQLVNHLPIKDPLIHATASIPVGLKTRILRDLSILEQNKIEPFFVFDGLRLTCKNKKVPDENYFKVCEEAWKSYSEGKFQQASNEFGQLANIEISSLYKTLINILLEKKMEFLVAPYLSWAQLAYMIETTQSHIDAIFGSSNILLFNVDRLIINFDFDYLIFSWLDKQTILSSLGGITNEQFLDICILLGSDFCPTFPPLEMIFQVNGDVFRFLQDAIKIFKSGINTILNYRHTFLTKYSDYLDSFFKAVCIIKYHIVLMENGKLLPLNESDAPSDIHEFISTRLPEEIYFYLSRGIIGPHVINILISGMLLENTPMDTSDIQEYKDFLDNIFVIQTQSLNLLTQPLHRFYQAKNISAYYWFEPDQEHKISHKMTPSIYELVKTWMIKEDIVNQIKMTIPENKINFLSFFKYLSDPKISKESVSEKTDNNIMQSNEQILSSIYGKFFQLRSFINNDHSLSAWGLALLDSLKICHESQQNSVVLIFELLRLKTFRQGNLFTTYQKESPEKNEEISSFIALISRVACLSVLHQKDVAWTGPLSKELFVFNSFIKILLQTIRNFVEMITASLFMNQDANRERDDWLEFTRLLPFNNEYDITMGVVIKTYLEKIITYENPTSEDSKKKAIEYLKSTFISAENIEEDIVKFRYLWNSIVYGIKVADILGVVDKIESDRFLKANNWLQERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJ17</accession>
    <name>M7PJ17_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873073.1">
        <property type="nucleotide sequence ID" value="XM_007874882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJ17"/>
    <dbReference type="GeneID" id="19894855"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01158"/>
    <dbReference type="HOGENOM" id="CLU_1200272_0_0_1"/>
    <dbReference type="OrthoDB" id="5368638at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="231" mass="27404" checksum="FDF75F99BC8B44B1" modified="2013-05-29" version="1">MQENEAPKPEETDPNSFRKAVEIVFNEVYFSVVPEKSIESQNLVKFEEKFQKAMLQMAAPKVESSPIYESYLQKDMINNDILKDKGDLLRSRGRSGQRRSQNLEGRKQVLGSKQFKLDGRRSKSKTVDGSILARSSIYAPKRRSRWRRNQNKSLINGQSFLCLPIIPDVTEVIVNKHRRYHDTLYRPFRKINLDYLWMMHWKLKSQKKVGKKYSTRDILFRMMSKWRKNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7PK34</accession>
    <name>M7PK34_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00942</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872854.1">
        <property type="nucleotide sequence ID" value="XM_007874663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PK34"/>
    <dbReference type="STRING" id="1069680.M7PK34"/>
    <dbReference type="GeneID" id="19894640"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00942"/>
    <dbReference type="eggNOG" id="KOG2789">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_669246_0_0_1"/>
    <dbReference type="OMA" id="ENHEYSE"/>
    <dbReference type="OrthoDB" id="21471at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24139">
        <property type="entry name" value="SIP5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039301">
        <property type="entry name" value="Sip5/DA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315">
        <property type="entry name" value="PROTEIN SIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315:SF1">
        <property type="entry name" value="PROTEIN SIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="47881" checksum="74E0F8470C999F75" modified="2013-05-29" version="1">MITPLKWSDFIESDNYGACIRTSIPLNLTLDGGFLTTNNFYQIPQDYKYVIVHQLMFEGKMAPFYRGLTEFNPLWSDKKLLEVVRQHLVIPFKDTVPLFTKDFPGGFYMKYISNIESDIYKLFEPHTFRFRSIVSLFRRFISACRFFKCPLEVSLYRKSEECFLCFLYYPKVNYTRCCNKPICSECFVQIRHLDSYPTSDKENGFENTFTLNNELIFCPFCSEKNFGIIYISSVQKHNTKFFTLPSLSNYRKLNNKSQKCFSEPPYVVTSDMIRPHWLYQLINTQQEVNQDALDGDQSNNLTLNNKHETSNSVENERQGMPSPQENDGYESTYFKMQGSILFKSVRLNLKNATYANYVAAIREKELATGQCINRPIITLYDGTILSLTDFVQHKNAFDSIVISSSSLKIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7PK60</accession>
    <name>M7PK60_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Restriction endonuclease type IV Mrr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872889.1">
        <property type="nucleotide sequence ID" value="XM_007874698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PK60"/>
    <dbReference type="GeneID" id="19894673"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00975"/>
    <dbReference type="eggNOG" id="ENOG502S6ZS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060368_0_0_1"/>
    <dbReference type="OMA" id="QGTLFEY"/>
    <dbReference type="OrthoDB" id="20734at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007560">
        <property type="entry name" value="Restrct_endonuc_IV_Mrr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018828">
        <property type="entry name" value="RRG7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133:SF1">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04471">
        <property type="entry name" value="Mrr_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Restriction endonuclease type IV Mrr" evidence="3">
        <location>
            <begin position="37"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="204" mass="24171" checksum="C5003BC1D7BB53E0" modified="2013-05-29" version="1">MFFFFKKRLSHTCLKTFFKYAQRTSLKPKSAYYKGVFYEYIVQNTLKKYNMDLWRVGGRNDQGIDLRGYWYYEREKTKYKLPVIIQCKNEKKKIGSKYIREMNGVLSGENEGILGLISCCGFTEMAQKQLLKASKAMGICIISSKNEDGFLEKFIWNMEASKLIQGFGVQFRYKEIDNIIQKELVLTIDNKPIKYKHYDEKENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7PKM8</accession>
    <name>M7PKM8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_00614</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Cytoplasmic vesicle</location>
            <location evidence="10 11">COPI-coated vesicle membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Golgi apparatus membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872512.1">
        <property type="nucleotide sequence ID" value="XM_007874321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PKM8"/>
    <dbReference type="STRING" id="1069680.M7PKM8"/>
    <dbReference type="GeneID" id="19894312"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00614"/>
    <dbReference type="eggNOG" id="KOG2635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019988_3_0_1"/>
    <dbReference type="OMA" id="CEDNETT"/>
    <dbReference type="OrthoDB" id="10266042at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09254">
        <property type="entry name" value="AP_delta-COPI_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14830">
        <property type="entry name" value="Delta_COP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000003">
        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="13">
        <location>
            <begin position="265"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR11014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="503" mass="58793" checksum="AABA94A276ADB4CC" modified="2013-05-29" version="1">MVILAASICTRGGKVILSRQFRDIPKARIEKLLATFPQLANTGIQHTTIETDYIRYVYQPLEELYMILITNIHSNILQDINTLHLFTETVINICHSYDEREILHNAFELLNAFDEITSYGYRENLSFAQIKSFLEMDSHEEKIQEIIARNKELEAVEERKRRAKQFELQRKESSKKGFNNFQSLSNNQYQLVSQSLHNMNLFHNIQDIEKKQVNKSVTLKGKGMQLNKKSKQIDYYETAKHSKNLKEHLFSNVSMKQSSTKDDTFEDIQIKISEDIHIAKTKDNDIESIEIKGDLHLRILQSNVAFFRVFLCDNDEEKIQYKTHPNIDKSQFLLNKVIAHRNSTKPFPVNNSLSVLKWRIIKKNEDIIFPLSVNLWTYENNKHIEMNIKYELTSNEYEFQNVLISIPMQSYSSILETTNGIIINHEKNSLEWFISEINSFNQSDSKKINLESNNAESFFPVSINFNMKTLLFNIDVIRVELINEEKEISFSKSIISSGEIIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7PL37</accession>
    <name>M7PL37_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein mgr2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00777</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872680.1">
        <property type="nucleotide sequence ID" value="XM_007874489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PL37"/>
    <dbReference type="STRING" id="1069680.M7PL37"/>
    <dbReference type="GeneID" id="19894475"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00777"/>
    <dbReference type="eggNOG" id="KOG4096">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142435_4_0_1"/>
    <dbReference type="OMA" id="SCWDRVK"/>
    <dbReference type="OrthoDB" id="5409308at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018450">
        <property type="entry name" value="Romo1/Mgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525:SF1">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10247">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01378">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8049" checksum="F448423DB0F54DEA" modified="2013-05-29" version="1">MASTFEKLKTGALMGSSVGLCAGLVFGTLHLLRYGSGRQGIIRTLSTSMISSAATFGFFMAIGTVIRTETLRKSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7PMC2</accession>
    <name>M7PMC2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">methylated diphthine methylhydrolase</fullName>
            <ecNumber evidence="6">3.1.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00063</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>diphthine methyl ester-[translation elongation factor 2] + H2O = diphthine-[translation elongation factor 2] + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42656"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="EC" id="3.1.1.97"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DPH7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.97" evidence="6"/>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871919.1">
        <property type="nucleotide sequence ID" value="XM_007873728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PMC2"/>
    <dbReference type="STRING" id="1069680.M7PMC2"/>
    <dbReference type="GeneID" id="19893761"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00063"/>
    <dbReference type="eggNOG" id="KOG0280">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036100_0_0_1"/>
    <dbReference type="OMA" id="LVCCMYD"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061685">
        <property type="term" value="F:diphthine methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052415">
        <property type="entry name" value="Diphthine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042:SF1">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="153"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="317" mass="36744" checksum="D2F57497C40CC477" modified="2013-05-29" version="1">MIAESKYTEYSPYPIDVILFSHIYLNLFVAGSYFLETKNKRKGHLFLYEVDYSGKTIKLIQNLECDAILDMKWISNSQEKLLITNSTGGISIYELLGPCNPILRCIWFKQIFDSNTLILSVSISSIRKSAIVSTSMGDLCIFDLNSLQVLQKWKAHELECWTACYNIDSSAIFSGSDDCTFKIWDIRSSAQPLFTNTKSHEAGVISFISFDKKLITGSFDDHIRLFDSRDFSKNVWKENMSSPWRLVQHSENQFRILGCLMYEGAKLFDLDILENDVYKVRVYKEFVEHESIVYAGDWYNEQEVVTCSFYDKKICLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7PMF0</accession>
    <name>M7PMF0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AMP deaminase</fullName>
            <ecNumber evidence="4">3.5.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Myoadenylate deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_00087</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871944.1">
        <property type="nucleotide sequence ID" value="XM_007873753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PMF0"/>
    <dbReference type="STRING" id="1069680.M7PMF0"/>
    <dbReference type="GeneID" id="19893785"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00087"/>
    <dbReference type="eggNOG" id="KOG1096">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003782_4_2_1"/>
    <dbReference type="OMA" id="SHHEMQE"/>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000001">
        <property type="entry name" value="AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01429">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF0">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR11649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="722" mass="86600" checksum="56D77EF213A2F9F0" modified="2013-05-29" version="1">MKMDQKDKESNRSFLNSYEEAHFFNDFCCIDYLIFKGLSYGKKEKNQENHNYLLSFKKLNSLENKTCIKKCTNSSYKNEIELNINPREVQERFNRCLYFREYYTLYKEAQNLYEDRTICESNLKSMKNLKNTCSSLYKCLILRNQYIKFSLQRHIDNPRHEKVWNIYPKDNEKFEIEKCVIPGKDNQIKYRYESSGIFQTYSSQNDMDIGNPVLTVPTICEFYENLKEIYIVINDESIKKFASERLKNLEDEWEKYIISHEKDEIIRIKQIPHRDFYNIRKVDTHIHHDATATQKHLLEFIKRKLENSPNDIVLYQDGKYHTLKDVFDSLNLTAYDLTIDILDMHAYKDTFQHFEVFNSKFNPFGRPIFKTIFLSTDNYMKGKYFAELTRELINKLEADKYKMAEYRLTIFGISLDEWDKLAEWVIDNNLFSPNVRWIIQVPRIYNVFKKIGTLNNMEEHIKNFFQPLFEITLDPSKNPKLHIFLQRVVGFDSVDDESKPEIELDSEFLTPSWDYLENPPYFYWHYYIYMNTAILNHWRRERGFNTFLFRPHSGEAGDINHLACSFLTSYSINHGILLEKNYAIQYLYYLAQIGISMSPISNNLLFLRFHENPFPLFFKRGLNVTLSTDDPVQFHFTEDPLLEEYAIATQIWNLSAVDMCELARTSVLQSGFEYKLKIKWFGDEFQDEKKTNIPKIRLDFRKKTFFYELFMLIQYITFDSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWT5</accession>
    <name>A0A0W4ZWT5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_04344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="KTW32843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613325.1">
        <property type="nucleotide sequence ID" value="XM_019757855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWT5"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZWT5"/>
    <dbReference type="GeneID" id="30671614"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04344"/>
    <dbReference type="eggNOG" id="KOG2414">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="1">
        <location>
            <begin position="186"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KTW32843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="573" mass="65642" checksum="B83487E0B972D9C4" modified="2016-03-16" version="1">MNISGRLPHVISLFDIRLQTPLPNIIILRGNDTEAEGVTVNGSVVFSLNDSISVESIMFRFYGVNKVKWTEVVMSSARMPVERNQKQMSLVFEKKISFLPFHGTKTIGKGNYEFPFEIHIPGDIPESIEPYEQGESMAFLIYKMKVTIKRPRFLSNIIHRKHVRIIRTMPPFSLNFIHTMYVEDTWINKIEYNINIPTKTYELGTMIPINMRFVPLIKNLKISKISCSLREYITLKITSGYHGIPSKYEIARQISASKIKNLPENENEWKLQKTVNIPSSLSSCIQNCDVKHIKVRHKLKIVITLINPDGHISELRASLPIVLLIPPAMFVSNEHYAYPSAMELQLPSYNSHVYDRIWDGVSSIHTNQSFAHETIAPSHIIDNSTNSTYSHDVNPTRSLSNDLEGQQYVEELQNAIQDQENDHNQANNHSSQYFIPSNTPYIILPTESTNQTSLQESEIYHNFSRPFSVGTNGHSFNAITDTGIQQTHQQGEDIFFNDFSQVPSYYTANHPASITATPISQSLPTYEASVSLPQQNTNQISTRQPQQTLRHRLFPLKLHTNRFFKVLFIRHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWU1</accession>
    <name>A0A0W4ZWU1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_04346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="KTW32845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613326.1">
        <property type="nucleotide sequence ID" value="XM_019757856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWU1"/>
    <dbReference type="GeneID" id="30671615"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04346"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KTW32845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="95" mass="11435" checksum="22FD5524C259BE2D" modified="2016-03-16" version="1">MFKINLFKTKLGNSQIEQSIYIILIFSISNINIFKNDIILRKSRFYLYTFFYLYFFCIFITIIPDDFASFIATIDITIDLILKTFLLYLYKTTSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZX21</accession>
    <name>A0A0W4ZX21_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cysteine proteinase 1, mitochondrial</fullName>
            <ecNumber evidence="8">3.4.22.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_04273</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.</text>
    </comment>
    <comment type="function">
        <text evidence="6">The normal physiological role of the enzyme is unknown, but it is not essential for the viability of yeast cells. Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. Acts as a repressor in the GAL4 regulatory system, but this does not require either the peptidase or nucleic acid-binding activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.</text>
            <dbReference type="EC" id="3.4.22.40"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homohexamer. Binds to nucleic acids. Binds single-stranded DNA and RNA with higher affinity than double-stranded DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.40" evidence="8"/>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="KTW32920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613390.1">
        <property type="nucleotide sequence ID" value="XM_019757795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZX21"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZX21"/>
    <dbReference type="GeneID" id="19893802"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04273"/>
    <dbReference type="eggNOG" id="KOG4128">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QSYTFFW"/>
    <dbReference type="OrthoDB" id="2666448at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070005">
        <property type="term" value="F:cysteine-type aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043418">
        <property type="term" value="P:homocysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00585">
        <property type="entry name" value="Peptidase_C1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000021">
        <property type="entry name" value="Bleomycin hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004134">
        <property type="entry name" value="Peptidase_C1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363:SF2">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03051">
        <property type="entry name" value="Peptidase_C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005700">
        <property type="entry name" value="PepC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0788">Thiol protease</keyword>
    <feature type="active site" evidence="9">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005700-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KTW32920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="482" mass="55585" checksum="8E7B96FCEE64B943" modified="2016-03-16" version="1">MAIEKYDIPINSQESSDELCKKFEKTLNLKTEYLIISAIQTNIFAEWEKKFLFCPKNRLALSAVSNGDLSSIIFQREAAILNNNHVYSDKIELEGSPVTYQRKSGRCWLFAVTNVIRVEFMKKYNLSEFEFSQAYLFFYDKLEKANYFLENILKTSEEALDSRIVSFLLSEPINDGGQYDMVVNLLNKYGLVPKHVYPDAYNAKDSVSLNRIIKMKLREYALILRSLVAKNATTTTISSFRAKMIEEIYVILAISLGIPPKPDDEFTWLYVDKDNKVNSYKTTPKLFYREFSQFKGDEYISLINDPRNEYGKMYTVDMLSNMAGGIGVRYLNTKMETLKEVAIKMIKENRPVFFGADSGKYIDRQSGIFDTALFNYELAFNVKSNLSKADRLRVGESLMTHAMVITAVHIEDGKPVKWRVQNSWGEDVGQKGWFMMTDEWMTEFVYQIVCHHSDLSEELQSVIKQVPIVLPPWDPMGSLARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NHJ5</accession>
    <name>M7NHJ5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal eL28/Mak16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_03480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875570.1">
        <property type="nucleotide sequence ID" value="XM_007877379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NHJ5"/>
    <dbReference type="STRING" id="1069680.M7NHJ5"/>
    <dbReference type="GeneID" id="19897167"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03480"/>
    <dbReference type="eggNOG" id="KOG3412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1652887_0_0_1"/>
    <dbReference type="OrthoDB" id="338850at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002672">
        <property type="entry name" value="Ribosomal_eL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10544">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="4">
        <location>
            <begin position="24"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="160" mass="18328" checksum="D4CBD2B15B3B0356" modified="2013-05-29" version="1">MGNSREKLTLNKPNFYESLSGDFVWACLKKNASFLVKQRVGKSVVFSKERLNPANRHTYSYCGLLNDKGLGLESGKNNKGLVVLMKNCPLESRNKPSSMVQKVYYAPKSYCYTIQRIERLITKKQYPLKLKRAAISRARLLLSSQTPKKPLPERKSRKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NHM7</accession>
    <name>M7NHM7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF2415 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_03513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875605.1">
        <property type="nucleotide sequence ID" value="XM_007877414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NHM7"/>
    <dbReference type="STRING" id="1069680.M7NHM7"/>
    <dbReference type="GeneID" id="19897200"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03513"/>
    <dbReference type="eggNOG" id="KOG2695">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_630235_0_0_1"/>
    <dbReference type="OMA" id="TESKAHM"/>
    <dbReference type="OrthoDB" id="128867at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052254">
        <property type="entry name" value="CUL4-DDB1_E3_ligase_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44472:SF1">
        <property type="entry name" value="DDB1 AND CUL4 ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44472">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="49460" checksum="0AB8EDF3796C2FEA" modified="2013-05-29" version="1">MIYLSNINILSYLYNSFLDEKKRRYFKISEDHVVGVSYPYSLGNIYKNKKKSIESKKQRTFAQTAKKIRTCFFQRNLNRELGKLHGGLFEHSLMYSYDMLWIERLFLFDRKELSLQGGSSITCLNFSPDMNNILFGTSDGLLGVVKVASITKHHEFLQLNISQSTSGLTSLNVSSNGIFICTFMGNEKKPGHFQIGTIRKNTEENLSDYGINVTVIPQGKNTLWASAIAPSGEIAAIGGSKMAMVIKGIDGANYTSYSYNLKSDVFAIKFLNTNTFLAGYRNGWIDLLDTRCLGSTKSCFTNSLIKHKSSISNFDLTSDYHLVVAGLENSLNMYDIRMIHSEKDMFSRPVLFFNGYTNECSFGLGFDISRNRRIVAASGQDQIYFWSTLDGRLLRRIMVKSNRACRAFKFYETSTNSFEELCLADDSYLEWWCSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NIS1</accession>
    <name>M7NIS1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="3 7">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_03324</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="3 7"/>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875400.1">
        <property type="nucleotide sequence ID" value="XM_007877209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NIS1"/>
    <dbReference type="STRING" id="1069680.M7NIS1"/>
    <dbReference type="GeneID" id="19897011"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03324"/>
    <dbReference type="eggNOG" id="KOG0042">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015740_4_1_1"/>
    <dbReference type="OMA" id="PHIVKPM"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.870:FF:000010">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00978">
        <property type="entry name" value="FAD_G3PDH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="8">
        <location>
            <begin position="76"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-glycerophosphate oxidase C-terminal" evidence="9">
        <location>
            <begin position="464"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="624" mass="69935" checksum="D981320F684749F2" modified="2013-05-29" version="1">MAQSQLFKVSGKRFTQILSVTMLVTMSVYCFRKEYISADPLKIGIPNPNMFSKILSREEQIEKLKSHPKNDGNEYDLLVIGGGATGAGCALDAASRGLKVALVEKYDFSSGTSSKSTKLIHGGIRYLEKAFTTLDWDQYALVQEALHERSIFLYNAPHLAFISPIMIPIYKWWKVPYFWVGVKIYDFLAGDKNTKSSYFLTKAKTLENFPMLRTNDLVGALVYYDGQHNDSRMNIGLILTSVLYGANVANYVEVFEFKKNENGKICGAVVRDCLTGDTWTIAAKGVINATGPFADILRNLDSSLTPKMLSLSSGTHIILPGYYSSPNIGFIDPSTSDGRVIFFLPWQGNTLIGTTDSPTKISFDPTPKEEEISWILSEVKKYLSPEFIVRREDVLAAWSGIRPLVHKPGSKDTRSLIRSHIIDVSDSGLLTISGGKWTTYRRMAEDTIDRAIKEFNLKPSSAKCLTQNVQLIGASGWSDTLYVSLIRQFGIDLDISKYLSENYGDRASSVLNMSKLTGKRGHVRGIRLSDKYPFIDGEVRYAVRMEYAQTCSDVLARRTRLAFLDVLASLDALPKVIDIMSEELNWSETRKELEWKNTIEFLCSMGLSETMRNLTRADVENGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>M7NIT8</accession>
    <name>M7NIT8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Polyadenylate-binding protein</fullName>
            <shortName evidence="13">PABP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PNEG_03000</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Binds the poly(A) tail of mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875050.1">
        <property type="nucleotide sequence ID" value="XM_007876859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NIT8"/>
    <dbReference type="STRING" id="1069680.M7NIT8"/>
    <dbReference type="GeneID" id="19896687"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03000"/>
    <dbReference type="eggNOG" id="KOG0123">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_22_4_1"/>
    <dbReference type="OMA" id="QQPGFMP"/>
    <dbReference type="OrthoDB" id="19742at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140693">
        <property type="term" value="F:molecular condensate scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008428">
        <property type="term" value="F:ribonuclease inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060211">
        <property type="term" value="P:regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12378">
        <property type="entry name" value="RRM1_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12379">
        <property type="entry name" value="RRM2_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12380">
        <property type="entry name" value="RRM3_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12381">
        <property type="entry name" value="RRM4_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1900.10:FF:000004">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000003">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000385">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000441">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000520">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006515">
        <property type="entry name" value="PABP_1234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034364">
        <property type="entry name" value="PABP_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045305">
        <property type="entry name" value="RRM2_I_PABPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01628">
        <property type="entry name" value="PABP-1234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00517">
        <property type="entry name" value="PolyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51309">
        <property type="entry name" value="PABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 12 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="71"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="159"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="252"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="355"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="15">
        <location>
            <begin position="590"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMR08518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="680" mass="74900" checksum="6757BF870FD065AF" modified="2013-05-29" version="1">MSLLAVESVSSVSPINISDASNKNVLGKSKLTRSDEVAPSTEAAGSADDSSRLNIGANVLVPVPQNSPNSASLYVGELDPSVTEAMLFELFNNIGAVASIRVCRDAVTRRSLGYAYVNFHNSSDGERALEELNYTLIKGKPCRIMWSQRDPSLRKTGTGNVFIKNLDSSIDNKALHDTFTAFGNILSCKVAVDELGNSKGYGFVHYKTSESAEAAIKHVNGMLLNNKKVYVGHHVSKKDRQSKFDAMKANFTNIYVKNINPEISEAEFEELFRKFGNVTSLSLSVDENGKSRGFGFVNYENHEDAARAVGELHDTEYKDRKLYVSRAQKKHEREEELKKQYEQAKLDKLNKYNGINLFVKNLDDDIDDERLRQEFSIFGTITSAKIMVDDNGKSKGFGFVCFSSPDEATKAITEMNQRMVSGKPLYVALAQRKDVRRSQLESQINARNQLRMQQQAAAAGMPPQYGIAGAPMFYGQGPGFMPAGPVTDRGIPFPQPGIVSSRPRWVPQQAGQPNGQAIPQMYSGMSGYNAYLTMQGRPQRSGQISRSPQGLPSRPIMSMGMRPAPAGARVYRIGSNIRNGTRDGIDVGNDNQLTAAALAAASPENQKQMLGEALYPKVQAQEVNFAGKITGMLLEMDNSELLHLIEDDVALRAKVEEALIVLKEYQKDYSVQDQTIEINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJ55</accession>
    <name>M7NJ55_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-alpha-acetyltransferase 40</fullName>
            <ecNumber evidence="4">2.3.1.257</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_03127</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-seryl-[histone H2A] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H2A] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50600"/>
            <dbReference type="Rhea" id="RHEA-COMP:12742"/>
            <dbReference type="Rhea" id="RHEA-COMP:12744"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-seryl-[histone H4] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H4] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50596"/>
            <dbReference type="Rhea" id="RHEA-COMP:12740"/>
            <dbReference type="Rhea" id="RHEA-COMP:12743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. NAA40 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.257" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875185.1">
        <property type="nucleotide sequence ID" value="XM_007876994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJ55"/>
    <dbReference type="STRING" id="1069680.M7NJ55"/>
    <dbReference type="GeneID" id="19896814"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03127"/>
    <dbReference type="eggNOG" id="KOG2488">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051699_1_2_1"/>
    <dbReference type="OMA" id="ANHINCY"/>
    <dbReference type="OrthoDB" id="424551at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043998">
        <property type="term" value="F:histone H2A acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039949">
        <property type="entry name" value="NAA40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="12">
        <location>
            <begin position="43"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR08653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="174" mass="20721" checksum="6DA2BEC88DA5C2E3" modified="2013-05-29" version="1">MDLKKDNIAKIANSLCLNDLRNLMPYDKIYNYKNDDIYEVELFDMKNIKEKDIYYCFCLVKENLEEMYKRSSFGWSSRRKLKEMKAKNTKYIIIRKEKKQDIIGFLSYQIVTEVGEHVIYCYEIQVLQAYRGFGVGYNLMKIMEILGLKLGLQKVMLTVFNCNISALRFYEKMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJ62</accession>
    <name>M7NJ62_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_03132</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875190.1">
        <property type="nucleotide sequence ID" value="XM_007876999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJ62"/>
    <dbReference type="STRING" id="1069680.M7NJ62"/>
    <dbReference type="GeneID" id="19896819"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03132"/>
    <dbReference type="eggNOG" id="KOG1135">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002227_1_0_1"/>
    <dbReference type="OMA" id="KCIASKV"/>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025069">
        <property type="entry name" value="Cpsf2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13299">
        <property type="entry name" value="CPSF100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Zn-dependent metallo-hydrolase RNA specificity" evidence="2">
        <location>
            <begin position="88"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Cleavage and polyadenylation specificity factor 2 C-terminal" evidence="3">
        <location>
            <begin position="203"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="298" mass="34162" checksum="FC59B2BA196E729D" modified="2013-05-29" version="1">MLPRCKMFPTLEKRRRFDDFGEIIIPERFVRVMEEDLDFNITNETNKSINILTKKRKWGGVSNNVQIRENIDKDIYIPSKIVVNEEKIMIKCSVRYIDMEGLHDGKSLKTIIPMVNPRKLVLIHSNQETRNNMMTIFKALVSFTNDIYSPQQGEILKIGIGLNSYNLKLSDDIINTLRWKKLGDYNVSHVIGKLKLCTSSVPNETDLPTLDVLPMNSNLKNIPQFHPLFVGDVKLAHVKRLLQEQGHVAEFIGEGMLLCDGLVTVKKIVGDKVILEGGISQEFYDVRKIVYDSIVEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJ87</accession>
    <name>M7NJ87_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02861</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PRA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874898.1">
        <property type="nucleotide sequence ID" value="XM_007876707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJ87"/>
    <dbReference type="STRING" id="1069680.M7NJ87"/>
    <dbReference type="GeneID" id="19896548"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02861"/>
    <dbReference type="eggNOG" id="KOG3142">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2039020_0_0_1"/>
    <dbReference type="OrthoDB" id="63113at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317:SF0">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="121" mass="14166" checksum="9D00E965A388C2F2" modified="2013-05-29" version="1">MDFGMNIFRNHIGSLQNFHKERFVNLQSFKEFLDFRRLAWPGSIVDVQQRMRYNLSRFSSNYAICFGLIVLYFLLTNPLLLFVLLFVTGGLFGINRLNGQNLHIGSFHLTPSQLYTGKYHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJ98</accession>
    <name>M7NJ98_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">SWIRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_02871</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes. Part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the RSC complex composed of at least arp9, arp42, rsc1, rsc4, rsc7, rsc9, rsc58, sfh1, snf21, ssr1, ssr2, ssr3 and ssr4. The complex interacts with histone and histone variant components of centromeric chromatin. Component of the SWI/SNF global transcription activator complex composed of at least arp9, arp42, snf5, snf22, snf30, sbf59, sol1, ssr1, ssr2, ssr3, ssr4 and tfg3.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874908.1">
        <property type="nucleotide sequence ID" value="XM_007876717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJ98"/>
    <dbReference type="STRING" id="1069680.M7NJ98"/>
    <dbReference type="GeneID" id="19896558"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02871"/>
    <dbReference type="eggNOG" id="KOG1279">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004447_3_0_1"/>
    <dbReference type="OMA" id="QQFNEME"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:histone binding"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02336">
        <property type="entry name" value="ZZ_RSC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000020">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000014">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041984">
        <property type="entry name" value="Rsc8/Ssr1/Ssr2_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032451">
        <property type="entry name" value="SMARCC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802:SF41">
        <property type="entry name" value="BRAHMA ASSOCIATED PROTEIN 155 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802">
        <property type="entry name" value="SWI/SNF COMPLEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16495">
        <property type="entry name" value="SWIRM-assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIRM" evidence="13">
        <location>
            <begin position="44"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="14">
        <location>
            <begin position="280"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="12">
        <location>
            <begin position="282"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="471"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00058697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR08693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="604" mass="68629" checksum="A95175D995494805" modified="2013-05-29" version="1">MDQLSGVAPSSEPFEIIKTEDPEVERKRLEDAARAFLVEQTHEVIIPSYAAWFDMSVINEIEKKSLPEFFNNRNRSKTPSVYKDYRDFMINIYRLNPIEYLTVTACRRNLAGDVCAIMRVHAFLEQWGLINYQIDLETRPSSMGPPFTGHFRVIADTPRGLQPFQPGPGSMTSHGRSLTEPSSSQTKTSYHLELRKESYDSIYGKSDNILTNGSKQTESGLDLKKQYFCFTCGVECSRLFYHSLKTKKFELCPNCYSEGRFPASFFSGDFVKMEETPIKGSKEDWSDQETLLLLEGLEMYDDDWNLVAEHVGTRTREQCVLRFLQLPIQDPYLESKTEDLGPLQYNRIPFSQADNPIMSVVAFLAGVVNPNIAAAAAQSSLEELTHSLKKHIDKQSDKNVTHDIDFKNDSDKSEIKQESSTHCDINQITKSEEMDIDEHKDLTSTKMLKNANISPSNTIEKAASIALGAAAAKAQILVSQEEREISRLVSEVIKLQLSKLELKLQQFNELEQILEAERQELEKHRQQLYLDRLSMKKQIIMVQEQLNQAISIGGEEGLLIIKKINELGCKGPKLEFISTDQDNLQASTIPLSQEDPSNYTSYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJE9</accession>
    <name>M7NJE9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_02913</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874953.1">
        <property type="nucleotide sequence ID" value="XM_007876762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJE9"/>
    <dbReference type="STRING" id="1069680.M7NJE9"/>
    <dbReference type="GeneID" id="19896600"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02913"/>
    <dbReference type="eggNOG" id="KOG0953">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010647_2_3_1"/>
    <dbReference type="OMA" id="FCEMIIF"/>
    <dbReference type="OrthoDB" id="6692397at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045025">
        <property type="term" value="C:mitochondrial degradosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000965">
        <property type="term" value="P:mitochondrial RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17913">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18805">
        <property type="entry name" value="SF2_C_suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000269">
        <property type="entry name" value="ATP-dependent RNA helicase SUPV3L1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000957">
        <property type="entry name" value="ATP-dependent RNA helicase SUV3L, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055206">
        <property type="entry name" value="DEXQc_SUV3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022192">
        <property type="entry name" value="SUV3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041082">
        <property type="entry name" value="Suv3_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044774">
        <property type="entry name" value="Suv3_DEXQc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22527">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12513">
        <property type="entry name" value="SUV3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18147">
        <property type="entry name" value="Suv3_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="190"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="350"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR08738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="679" mass="77690" checksum="59EED6E32797F58F" modified="2013-05-29" version="1">MVSLCLYKVCPFFCDFLGLQRGFMHVFLKKRDIYGVWRFFSFNSGAYIGKILRFSNNRRKNALKPIKTKRYWNFSKLLRKRIEYFVHIRLFEKLIDGKSEFRGEIHKLPKIFSENLLKQLKNTKKAIGVDSSPIIYDLWLSYVSEGVLGIDRMLKKSFLMFLMVRNLSVGEISRQKLLSDMRYPSEWFPGARALERKWYLHIGPTNSGKTYQALKKLEKARSGWFAGPLRLLAREVYDKMLSKGIVCNLITGEERIIMDRNAAVHVSTVEMVDLNKLMDVIVVDEVQMIADSQRGWAWTQVLLGAQASEIHLCGEESSSELISRIAESVGEELKIYRYERLSPLEPLNHSLYGDLKKIEPGDCIVTFSRKNIFLLKKKIEKATGQRCAVAYGGLPPETRNEQARLFNDPDNEYRVLVASDAIGMGLNLNIRRIVFQTLEKWNGTKFLPVSVSQIKQIAGRAGRYKSISANMLEASMSGYVTSLEQKDIRPLHTALSQPLQTLKKAILFPPLHIQELFASFFRPGTSLALIIRRFQKLSKTTGLYSILDTTQQETILELLESISDLTISERLILSAAPINLKDSEVISAFLAFATIISLGKPRTILEIPEVDLECLDCKVDLDLKQLERLEVLHKMLLIFLWLSNRFPAILLSGPECQEVKKTCENLINKNLSKISYVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJJ7</accession>
    <name>M7NJJ7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDENN FNIP1/2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874983.1">
        <property type="nucleotide sequence ID" value="XM_007876792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJJ7"/>
    <dbReference type="GeneID" id="19896627"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02940"/>
    <dbReference type="eggNOG" id="ENOG502R9AK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_370496_0_0_1"/>
    <dbReference type="OrthoDB" id="10051712at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037545">
        <property type="entry name" value="DENN_FNIP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21634">
        <property type="entry name" value="RE13835P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21634:SF9">
        <property type="entry name" value="RE13835P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51836">
        <property type="entry name" value="DENN_FNIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN FNIP1/2-type" evidence="1">
        <location>
            <begin position="38"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="751" mass="85753" checksum="11D00EAA6D996B4C" modified="2013-05-29" version="1">MLSWLFPKKIDSFLTENINNDTFQLLHPFPNCFGIEKLKSDDIRVIIAQNIDNKAKTILFDSEKICEKEIGCSQYIKACRNEEGIKKNYSNVLLSDLNRNTYFKQTISTEMISDLMFGTVPMTYQGTITKLHPLFSSGTFFHSFLLTKLFTIESDASFSTSNSNNFSASDRYNDSLTDLSLKDSLLPNMTSFEEHKKNVLLRKESESLFTLSRLGSWESSKSIIDQSKKYPFLTNIPKMTGMSRESFKKSKPYVYAIGIIITLNINSGDFQDGYQIINQYWSILNNAANALQRSVFSVISKSLENVNCVFYKDCETLEISRIASDTNRRNFMMNSISLYNDTIICAVLKFKERILTAISAPLVIHIPKRTEQKFKEEFKALFRELDNKPCKFFFSVLLTAILSSHMEITSDFLSRDLTEILSEKKLENIVIISKNSSLARRIIYVLSGLIFHDLRNIQIIDYLWPSEGLLCLSRNHLRPCRSKESLPKQIFGWDIPYCCPLSKVQTYSMSASSIDSKMSSASTSDYAIRQSNGLYGSRLGSWFSSFLTQKNHETIVANNSNLNEDSDLQSHMSGSFHDQCSSLTSDDEDMIKSLTKVSAKLNDKGIIEIDPLNTVTEFENSSQVIDLNFHSTPYITGYLDSIHFDFILQACPPSINLELQIQNQLKQRSIDIRDSLHEFKPSEDIVSILVADLSNCAIKKFTLQRSHTDSLSSNIDENIQQMHNEHRIFNETLTCIDSSLIENIYNYILVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJR1</accession>
    <name>M7NJR1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_02635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874654.1">
        <property type="nucleotide sequence ID" value="XM_007876463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJR1"/>
    <dbReference type="GeneID" id="19896326"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02635"/>
    <dbReference type="HOGENOM" id="CLU_546427_0_0_1"/>
    <dbReference type="OrthoDB" id="5322777at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="499" mass="56145" checksum="D872DA0368D1F8D8" modified="2013-05-29" version="1">MENYDEIYNENYGHEHCDGKQGIRRGTARCESCVKIAQVREKCRASRSRVTHMIHEENAGPMADITKKSFKEYIRLCVRRIKKFAATGFARINAFRKDDISNIVFVMVDRTNSRSRCSFLRIDSNGNTQRIPRDSILGTNLLNSLPNILTSSSDQHSCRQKITHNPVYYPNSHKRLHAPQRLRFNIASPILSIQSTESTRVNISRKCTTPFDDGYDANKFNNSSDEISDTATSQIFSTKAQLSQLSFLSNNQTDLNTPTPCPVKNVSSSSVLKSNFMFNTNSATSTQESCNFDKEMRYMRLQHAISHELRDLVAASHGLENRDNSAFNSTKTINTYPPISRKTSMINSKRYGKIFSSPEKNFLNQSEFFLTPRNLKMKSRSTFATEPIDFQIPTLDSAKSSITTFDKGSDTSPPLRTSTESTVVSSTTASIKCQIFSKIAKGRNALIPPKLSASNNINKRTSLASNTKLNKGNLGTVSKLIELFEGLTWNEEKKQSRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NK84</accession>
    <name>M7NK84_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cell division control protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02815</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC45 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874849.1">
        <property type="nucleotide sequence ID" value="XM_007876658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NK84"/>
    <dbReference type="STRING" id="1069680.M7NK84"/>
    <dbReference type="GeneID" id="19896504"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02815"/>
    <dbReference type="eggNOG" id="KOG2475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005871_3_0_1"/>
    <dbReference type="OMA" id="EDCFMEA"/>
    <dbReference type="OrthoDB" id="10258882at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003874">
        <property type="entry name" value="CDC45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507">
        <property type="entry name" value="CDC45-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507:SF0">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 45 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02724">
        <property type="entry name" value="CDC45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="661" mass="76058" checksum="80EB14EBE1E2E5F3" modified="2013-05-29" version="1">MFIRRSNYVDAYSRIKAASLSGSCTVLIFVALEVDALCACKMLSTIMKHDFISHKIQPVSGYQDIMDINQTVVLNNENLRFLILLNCGALIDLSQYLTPQDYVTIYVIDSHRPWNLDNAFSDNNIFVFDDGDIEEKLSEERRAYEALAEASDSELERDDDYDDSISDEKDFFFEDENFEKSKLEKQNTLVSNNNLEDLVSSGDAKNKEVSSDPAQLSLDCPAKHDSRSAKRKQYYKYQRIISNYYDSGTWFGECISSQVYSLASDIGREDNELLWLAIIGLTSQEIHRRTSYNKYLQLYSLFKDEVNRLNPPVLDTKNIKRANGRTADDSSIKARDEFRFMLVRHWSLYDAMLHSSYLGAKLKIWSEYGKKKLHKLFAKMGISLQQCRQIYTHMDIDLKKNLQEKLDRFAPLYGLNDLIYPSFIRTFGFKCTLSASDASYGLSALLETGKHKCEKYDPNKENERPLKNIEHGNKQEDMVRDLWLTYFYDAFDALDNIDALYSSLSVAMELQRAIVRTGTYLIDKRAIRHLKAFRIAVLKEGPDLGIFTHPFALSKLAIWVADAINEQEREQGRTRHLPFVIASLNERTDTYLLLGTSVSTSSDELEDNASYNRNRFGLIFSQVAQATSARLKMDAFDAYCVEVYKQDLANFLEILSTKIMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NKH0</accession>
    <name>M7NKH0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Nucleoporin Nup133/Nup155-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_02481</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874490.1">
        <property type="nucleotide sequence ID" value="XM_007876299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NKH0"/>
    <dbReference type="STRING" id="1069680.M7NKH0"/>
    <dbReference type="GeneID" id="19896174"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02481"/>
    <dbReference type="eggNOG" id="KOG4121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_274527_0_0_1"/>
    <dbReference type="OMA" id="HVATLLW"/>
    <dbReference type="OrthoDB" id="103454at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="8">
        <location>
            <begin position="501"/>
            <end position="1116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR09138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1135" mass="129628" checksum="B066170F45E03E9D" modified="2013-05-29" version="1">MGSFDSQTGYGLVVTNTAAYVFSYLHSGPDHHPVTLTFPLPQDMAKDRFLNKDVLPLGALVAPCAGSDEPGLVIIMPISGRIAYWESIGGAIAEGLIHKKSIEGRIPLVSGEMCVCLCNAEPANFVLATSSGKLLHLSLVDSSARLHIGLLNMTSSSGIGGLFSSLTGALWSATTRRDICSINAGELKGRGTRDVIVCTKRGTVSKWEVTRSGYAKLILEKNLWNSMVEILISTLNISLSMIEKSLQIYDIMPIPNSTSLVLILASFFVSLDSPNYVLFISDLESTTLKVTSVHLLQYHGLYSDLLFHPRILIPKPGDMTIIVFSDALYLILTPTEATFDSEILFEDIITFNRENRVQILAAGYEDSLIDPSSKKIIRNPSVLVATKNAGILRCETFKITRLHKDLISRKNRRKLDQAVFYGFLEGNPINFCWTSEYDIENIQAVAINLSHDILTSVSKYHSSSFIPLENDLFLKSLNLSRLSEYLLFNFDSINSETRWKLCWDAEKCESAQNLWSKINTRLTKVEDNIINDIIKSLVTKETGKNVIRWWFQKGLQNIACIVSKAYKCCLDVISLVEKDGLRVLKTIVEANEIILAILVSAQKFRKKRAEFLKLNEPLHSNDNSLLPWTSSSDILSVLSNQYNLTNAIMLEFKRDNLLLEDKVQNTLNSVESMKISLKETLVTQLIDLAELICCSFEERILWTKSIQMNSLDDEKKHIEEKYLSSRGNWIKFLAEIDKLDKSFEIAEKYRDFRTLVELCYETDDKNMDYNWNDQVTRRINWYLYTFKEEFADVLYRYFIEKGHLFNLLEDFSDYHYYLSRFFDSGNYGRISWMHEISTDRFKDAGNTLYNIAKNDEIFVFNKRVELSISKLCFLEYLESHNMEKINCLPLINIEYQLEALQIQASLLDEIRSFIENAIDIDAAVDLVVEKIGHSLKKRPATKIVFKRALKNLILEKILDPEDLIDLLTLKDKKTTSYGISANEYYSALKVLNSSQLPLIRHQSVEKTIWRRIFIANDWTKILDTRNKADTSVEADTKYTALYETINLCVISQFFENSNIYPISPKNAYFDPKLDDLRSRFSKNTHDSEINAFSNELLKENQLLDKYEVKATLDSWFIAIMEALKLQIPPDNQKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NKQ3</accession>
    <name>M7NKQ3_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02559</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874572.1">
        <property type="nucleotide sequence ID" value="XM_007876381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NKQ3"/>
    <dbReference type="STRING" id="1069680.M7NKQ3"/>
    <dbReference type="GeneID" id="19896251"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02559"/>
    <dbReference type="eggNOG" id="KOG0308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002197_0_0_1"/>
    <dbReference type="OMA" id="NAYSMLR"/>
    <dbReference type="OrthoDB" id="2421129at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17041">
        <property type="entry name" value="Ubl_WDR48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051246">
        <property type="entry name" value="WDR48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021772">
        <property type="entry name" value="WDR48/Bun107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862:SF14">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11816">
        <property type="entry name" value="DUF3337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="129"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="172"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="259"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="986" mass="112919" checksum="A6A199ED5082255F" modified="2013-05-29" version="1">MSKYNIQYVLPLDESKKGHRLGLNAVTIDPLKDGGRLYTAGRDGIIFSWNLNLHFRNKRDFREYKYKNEAYGEESSDILESEDIMNNFNTHIIRKKEHTTHILDESRTNNTGIDVCVFKDKGPSYHSEVQAHMHWINDLALVDLSRFIVSCSSDHTIKMWKTDNFELEALTIGKHEDYVKCLATPKNCSTWIASGGLDRKIIIWDLHSQNKVLDIDTSIDGPKGGVYALGAKQELITSGCPSGVVHVWDKRSGQSIASFTGHKDAIRTILISDDGQTILSGSSDTTIKAWSLGERRCLLTFTIHGSSVWSLFSQDPRLNTFYSGDRSGYLMRTRTMLLSEEENVSYIICREQSGINRIVTVDSLIWTSTSSPNIHCWLDAPLDFTAQKSFNTSKLQNIPTFSEKAFVEPSLVAESLISPYDTNMFESNYTENSISNECHFFSSCCVYNENPLECKKNIIPLRKLPQYTIQSQIGLVKHILLNDRRHVLTVDTQDEVSLWNIITCTHVKNYGKCDINELEKKLNTLDYVANWCHVDTRIGALTVSLNENSCFDAEVYADQIDICKDCEYNEDHKINLGKWVLRCLFNNFIEVQIKNDNQYRHSILDISLDDLKADKTLLPLYNFPDLFQNGSQSIPDLLETSKKISSDENISIIDSILTRSSKEASSIHDNGNIEKKSSSLDILNKENNLFNKQDSQTKMTKLEESLFASIDPNDHSTNSFTFIDRLKFFRTKKVLKTIPKDSKAQGDLQNIEKKDTLSTDLKNFQSLLNPEIQKTNVLHTHHFVSDIINSLRNDYRLSRLSHPDILIATKIYPICSDEAPILQLPHNTILIISKEKSITDNTINVYKGKIGCIIQHVDILENVLPAWLGNMLLFNKIPNEEIQKINFILQPYQNCHLPKIYDENKECTASGMLRVRKILIYILKHLNKMELLDTNPENYLQLICNKEILSIKTTLITIKTRIWKSKGSIILHYRPLNKEIYETYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLL7</accession>
    <name>M7NLL7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein HIR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_02145</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874125.1">
        <property type="nucleotide sequence ID" value="XM_007875934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLL7"/>
    <dbReference type="STRING" id="1069680.M7NLL7"/>
    <dbReference type="GeneID" id="19895838"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02145"/>
    <dbReference type="eggNOG" id="KOG0973">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004372_3_0_1"/>
    <dbReference type="OMA" id="RGSWDGD"/>
    <dbReference type="OrthoDB" id="1741719at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031120">
        <property type="entry name" value="HIR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011494">
        <property type="entry name" value="HIRA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019015">
        <property type="entry name" value="HIRA_B_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831">
        <property type="entry name" value="MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831:SF0">
        <property type="entry name" value="PROTEIN HIRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07569">
        <property type="entry name" value="Hira"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09453">
        <property type="entry name" value="HIRA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="14"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="14">
        <location>
            <begin position="29"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="64"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="124"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="166"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HIRA-like C-terminal" evidence="13">
        <location>
            <begin position="669"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="537"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="507"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="544"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR09558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="947" mass="105329" checksum="0F3839BF9E18DD93" modified="2013-05-29" version="1">MLFIKPSWLGHFDERNEAKAIFSVHISPDGSRLASGGFDSKVKIWSTKAILEEDSNEPKQLCSMSIHTGVVTTVRFSPNGKYLASGSDDRIIIIWQIDLLGHNFGKMFGSNETNVENWRSFRRLIGHDNDIQDLAWIHDNSILVSVGLDSAIIVWHGSTFEKLKKIDAHQSHVKGITFDPVGKYFATESDDRTIKIWRTSDYCLEKTVSKPFKNSPSTTYFRRPSWSPDGLHIAGANAMNGPVSSVAVIERGTWTSLINLIGHEGAVEVTSFNPIIFRLPNTNKEDNKIMTIIACAGQDRTLSIWNTMNPRPILVTQEIAEKSIGDLCWSPDGLCLFLCSYDGSIVACLFDKDEFGEPLTAAETEKLLSKYGHGRHGTVLPESTAQLELEAKTNEAEANAHVKRMEDLMGGIEPVKIDCTSNETKSEILNKEMESTAYTEKCQTTLISKEPQINTTLSSIPSNNIHKSVQQKVSITKDGKKRVTPQLLSNLSDAPIENPLSGSLLQTSSEEQKPAQTLDLSEPSYALPKGGIRSLIIGNKRKNRPEENEEQHTFQKKGKMKQTNDQTKIDVPEFIRPAVICPSTSVSQIRLGVPKVITFLSMYVNITNNTLDVRNGTGEHKPTRITVTKKGNILWTEFLPKAVLLLAGNTLFWAVGCEDGTIIIWSPHGRRLFPSIVLESSPCFLECQGPFLMCITSIGLLHVWNIVLESSPHPPVSLAPILDASVFQSSELKSAPSIVSASINSLGQVIITLSDGDGFTYNAAMYSWLKISESWWAVGSQYWDSSGFKGTAGKSGIIAMLERRTDDEIMKLGRGRFLQKIVKSAMLLEGYESFETSVSISHLENRLSSAAILHSPDEYKTILNVYTRKIAEENMKDKLEELCMYLLGPILDDPYITWKPKVAGLDKRELLKEILITIGKQREVQRITTKYIEALQELNKSTDISTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M7NM43</accession>
    <name>M7NM43_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873899.1">
        <property type="nucleotide sequence ID" value="XM_007875708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NM43"/>
    <dbReference type="STRING" id="1069680.M7NM43"/>
    <dbReference type="GeneID" id="19895617"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01923"/>
    <dbReference type="eggNOG" id="ENOG502QZS0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_435528_0_0_1"/>
    <dbReference type="OMA" id="NDAIHAY"/>
    <dbReference type="OrthoDB" id="2245455at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37327">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37327:SF1">
        <property type="entry name" value="MICROTUBULE INTERACTING AND TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIT" evidence="1">
        <location>
            <begin position="14"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="628" mass="71825" checksum="3798CB5EE8832C2C" modified="2013-05-29" version="1" fragment="single">MDSSNLEEHLKAMLTDAFNKAQTAVLLDSSNNINDAIHAYTQACSLLKEVITQLPEGKYQERLQVIYRTYLERVQLLDGLHHSDLDDADESVFADAQTTASSPVGFFPESSHSESYDKSNSCTSDLSKKSFTMNYIKQISFSDINLLSPIKYLLKPIKEIISPPPSFSASPIQAESVIPSDSKSLELVKNTDDIETDDKTVEEKKSVPSEKVPVENDSDLVSKQIFSLNSTFANWSPLLDASCIFSQADDSKKPIFQYDSADSLIFEETHIAPFLKVCSDHELQKENQHTDIFQENTSNEKKDTFMYQDDRSFSETKRKLYSLYNNSCVSLNYSDKLSTNFSDILTNSSAQISTTTLIPSSSSNKTRHSDIYMSFLHDNILPKTALLEVDPIHMQKPKDSIEKTYWLMKILQKLLIPFIIKSEGSYITPRLFIPKDIWYVKNVKLKGEEEKIKVCESLIFTLNKIKSLKQDDLQSLIRELVYLDNMVDIFRFWLLKKFGTEVVNPKKRYGIIKFISKSKFLIKTPPPNEFNTHKFGIVQFDGPRKSYLTSIYRLFGSAQIIGQVLNIFDFHELPLKAQDSIHQILINISDFFENVVCHFVLIDINVLLDHFIKQLLYGNDYNPIIGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMG0</accession>
    <name>M7NMG0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PNEG_03144</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875204.1">
        <property type="nucleotide sequence ID" value="XM_007877013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMG0"/>
    <dbReference type="STRING" id="1069680.M7NMG0"/>
    <dbReference type="GeneID" id="19896831"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03144"/>
    <dbReference type="eggNOG" id="KOG1720">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017787_1_2_1"/>
    <dbReference type="OMA" id="RIMRPGM"/>
    <dbReference type="OrthoDB" id="5632at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120105">
        <property type="term" value="C:mitotic actomyosin contractile ring, intermediate layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071958">
        <property type="term" value="C:new mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140602">
        <property type="term" value="C:nucleolar peripheral inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030869">
        <property type="term" value="C:RENT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071470">
        <property type="term" value="P:cellular response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140013">
        <property type="term" value="P:meiotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051229">
        <property type="term" value="P:meiotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044878">
        <property type="term" value="P:mitotic cytokinesis checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016479">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031536">
        <property type="term" value="P:positive regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903501">
        <property type="term" value="P:positive regulation of mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140429">
        <property type="term" value="P:positive regulation of mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902846">
        <property type="term" value="P:positive regulation of mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031031">
        <property type="term" value="P:positive regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070550">
        <property type="term" value="P:rDNA chromatin condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14499">
        <property type="entry name" value="CDC14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17657">
        <property type="entry name" value="CDC14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000038">
        <property type="entry name" value="Tyrosine-protein phosphatase CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044506">
        <property type="entry name" value="CDC14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029260">
        <property type="entry name" value="DSPn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14671">
        <property type="entry name" value="DSPn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0469">Meiosis</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="15">
        <location>
            <begin position="189"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="16">
        <location>
            <begin position="263"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="352"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="365"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMR08301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="496" mass="56506" checksum="F1A892149A713995" modified="2013-05-29" version="1">MKRLLSGHMLEFLEDRIYLMTLDEKPSGEILSQFHFFTIDDSLVYNPFHHDFGPLNIAHLYRFALTMHEMLSNPVIREKPLILYSKNDNRNRTCAACLIACYMVLIQNWPPHLALAPLIEADPPYTPFRDAGYAPADYGISIQDCVYGLWKAKEAGILNIKNLDLEEYETYERVEYGDFNWITPHFIAFASPVQPGYIVNGKQKNVITPTFMSILKYFSSHRVGLVIRLNKPLYDKRQFEKLGVEHVDMFFEDGTCPDLEVVRKFCGLVEEILEKDLVVAVHCKAGLGRTGCLIGAYLIYKYSFTANEVIAYMRVMRPGMVVGPQQHWLHINQHHFKTWTLKSLPRWTKATKFSTPPRSPLGNIDKNNSVENTSLPVPTSGQPRKNISSPRRSRVISLGGNLREALIEVAEQKSAKITEGLLNKYREGYLIDSTNLLEHTHKEILKQNNPFTTASKKIGNHGERKTSINANSNSTLNMMSISSGRIVKNRSSKGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M7NML7</accession>
    <name>M7NML7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_03295</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875370.1">
        <property type="nucleotide sequence ID" value="XM_007877179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NML7"/>
    <dbReference type="STRING" id="1069680.M7NML7"/>
    <dbReference type="GeneID" id="19896982"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03295"/>
    <dbReference type="eggNOG" id="KOG0018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001042_0_1_1"/>
    <dbReference type="OMA" id="KHMDFQR"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03275">
        <property type="entry name" value="ABC_SMC1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028468">
        <property type="entry name" value="Smc1_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF12">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="12">
        <location>
            <begin position="480"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="347"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="639"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="816"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="994"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR08467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1191" mass="138832" checksum="B8BD224B8714DB33" modified="2013-05-29" version="1">MDAISFVLGLKSSQLRSSHFTDLIYHEQLAPNKENSHKNLENRIKDAWVMLVYEDDSGNHIQYKRTISSSGTTEYIINNKIVTAATYNKALEGHNILIKAKNFLVFQGDVETIASQSPKDLTRLIEQISGSLEYKCEYERLKIEQERAIDNSTYAFHRKRGINAEIKQYKEQKAEAENYATKLDQRDNAITLHLTWKLFHLECKINNNKEIISHNISKSKELDIEKKKYQENLNETKKIQAKITKEILKQEKSIKEKEKALEEQLPILIAAKEKIDSANISISKCNSRINEIERDKSRQSNHLLSFEKDLSIVKKAFQRFEEEQTKLAKQKGVIFSDADFEEYKKLKDEVNSKMSIQKQELENLHRQHKVDSESANVLQENYNQLKRQKDILEEEVYLLSIQKSEVTSKVNQLIQDLDKERNNLEVIRSSRIRIAQQEIELNEKLQECLNKLLQINADKRESERELKTKDIINTLKRIFPGVRGRIIDLYRPTQRKYEIAIATVCGKNINSIVVNNQKIAKECIEYLRDQRLGILTFIPLDTCQIKSIDQKLRNIHPQARLAVDVISYESSIERAIQFATGNALICDDFNIAKSIRYNKNIETKIVTLDGTVLHKAGLITGGQNHNFKQEYNRWDEQEIEALKQLRDNLISQLQDIQKDKRKDMTEEVASSNISGLEPQLQFSREDLNMIQRNLNGKKEEIEHIKKQSEEISQKLEKDQNLLVQHAKKISKLQSEINNIEDKIFQDFCSKIKIKNIRQYENKHETWTQEAAEKRMKFLTQESKLNNQLTFEKQKFNETSERIKKLQMFITRDSSLILQLEEEKKETQETIDILKAQLAQKREIHTIKKKEHSEKTQIANELHQKINKWTKQIDSLSKINSEIESEIERISFERYTIFKRCKLEEINIPLISGSLNDIPIDESIMQNHINTENEETNRIKTKICDWKIEVDYSLLDKNLKEDGSIDMENLLSEKISDLTSEIEKIAPNMKAIERLEGVENKLHDTEKYFDKARKETKQARDNFNAIKQKRYALFHKAYTHISEQIDQIYKDLTKSKSFPLGGTAYLSLEDTEEPYLNGVKYHAMPPMKRFRDMEQLSGGEKTIAALALLFAIHSYHPSPFFVLDEIDAALDNTNVTKIANYIRQHAGNGFQFIVISLKNALFHQSEALVGIYREHTSNSSRSLTLNLQDYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMT4</accession>
    <name>M7NMT4_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873715.1">
        <property type="nucleotide sequence ID" value="XM_007875524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMT4"/>
    <dbReference type="STRING" id="1069680.M7NMT4"/>
    <dbReference type="GeneID" id="19895445"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01751"/>
    <dbReference type="eggNOG" id="ENOG502SGAD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_451357_0_0_1"/>
    <dbReference type="OMA" id="LRTWQQK"/>
    <dbReference type="OrthoDB" id="3260408at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="605" mass="71824" checksum="B230F6A1783F6C4C" modified="2013-05-29" version="1">MMYKRQNISGLFFGMTLKLFILFTVYKLFFVCPLESPSKTKMLLCRNYHYLKSSMDPYLKSIYYKYALEQVEMVEPYLKNVQKNVGKYSKPAIKHIKDQYENYIYPYFVYGKESIYKFVKKHIGPVKIKYIKEYDRFYRNRFKDYLVYSKKVYWTHIYPGIYSTRQTVIYIYQSKLIPFYQQTKPHVIHFLKTMLQFLIREVYPRIVEGLIWLKDFFFTYAVPKFNDFWITHVNPQLERIYDRIFQYKNSDYNIASETQSSRYESPEENILDQKKNTHISYDQTENQLFSEILSLWTDRLNKIGKEIEEALIEDLVDVFLPVIYKKEKAVIQNLLNELNLLVNSEISKIKNKIIPKDNVLKGAKKDIFYNIDDIKEAGKTIHAKALEIRKYLKSIENDCKKKIIKKSKLYFNQVIIFQSEITSLFEVFIKLSTKDENYKKVYNKYFDFKNLIDTIEKQFFDSILNSTLSSVKQIRNLSIKAELAVNNITGLAAKQLKDFKSINASNNITQKLYDDPTDENNALSKLSEKSKDQSIVLDNSKQETEQENEKMESEHPVLNQDSDSYMEKQVNSNSNPSDNKDSMENINYDSSQTDPLHLQKETIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMU5</accession>
    <name>M7NMU5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_03281</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. MAK3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875354.1">
        <property type="nucleotide sequence ID" value="XM_007877163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMU5"/>
    <dbReference type="STRING" id="1069680.M7NMU5"/>
    <dbReference type="GeneID" id="19896968"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03281"/>
    <dbReference type="eggNOG" id="KOG3139">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_0_3_1"/>
    <dbReference type="OMA" id="IMNLITH"/>
    <dbReference type="OrthoDB" id="249099at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044542">
        <property type="entry name" value="NAA30-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="133" mass="15685" checksum="4F205568D3073E76" modified="2013-05-29" version="1">MKIKIENYKDESQLPSIMNLITHDLSEPYSIYAKEEDIIVGAIICKLENHKKCLRGYIAMIAVKKEYRRKGIASKMVEKVLSIMKEKNTDEVILETEVTNKEAIILYENFGFIRDKRLHKYYLNTSDAYRYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN17</accession>
    <name>M7NN17_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">General negative regulator of transcription subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_01829</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873800.1">
        <property type="nucleotide sequence ID" value="XM_007875609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN17"/>
    <dbReference type="STRING" id="1069680.M7NN17"/>
    <dbReference type="GeneID" id="19895523"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01829"/>
    <dbReference type="eggNOG" id="KOG2150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013819_3_0_1"/>
    <dbReference type="OMA" id="YKPQTPY"/>
    <dbReference type="OrthoDB" id="293823at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000006">
        <property type="entry name" value="CCR4-NOT transcription complex, subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012270">
        <property type="entry name" value="CCR4-NOT_su3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04065">
        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005290">
        <property type="entry name" value="NOT_su_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-Not complex component Not N-terminal" evidence="13">
        <location>
            <begin position="3"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="14">
        <location>
            <begin position="460"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="247"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="329"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="124"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR10078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="589" mass="68143" checksum="DB5B7660B1612E61" modified="2013-05-29" version="1">MTARKLQAEVDKTLKKVTEGVAAFESIYEKMQSASNQSQKDKLESDLKKEIKKLQRMRDHIKTWASSNDIKDKKPLQENRKLIEMQMERFKACEKEIKTKAFSKEGLLSGLKLDPKEKERLEVSHWLSSMVDELERQIEQLEIESEILQGSLKKKNKDYVKSERLERVEHLLERHKWHQDKLELILRLLENGNLQTEQVLSIQEDIKYYVESNQDTDFTEDENIYDDLNLSEIFGRTLDNEIDSSLETQSLADETSPCSQKDKDERTKSTESLNIIASHKAKSKSPILVDTSTHQNTNETTKASQSKTQIDALKQLSTIYPLNTNAAFPSPSSDAKASTAASSTSQEASPVTSFSNPQHELIKSSDIQETTDEYREKNISEPLENTDSSLETLSHEIAIDTSPVEKSSMESQTHTSNLTDLSRFPHYLKDLVSSLKTIKQKTLNPPPISIIHRLLEVSFTTAPEPVNSESPKYYTPSEPCSVPPYYPQVPPAIFDSPELFEKIDIDALFFVFYYQQGTYQQYLAAKELKKQAWRFHKKYLTWFQRHEEPKIITDEYESGTYRYFDFEGAWVQRKKPDFKFQYVYLEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNJ9</accession>
    <name>M7NNJ9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major surface glycoprotein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02989</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08822.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875037.2">
        <property type="nucleotide sequence ID" value="XM_007876846.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNJ9"/>
    <dbReference type="STRING" id="1069680.M7NNJ9"/>
    <dbReference type="GeneID" id="19896676"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02989"/>
    <dbReference type="HOGENOM" id="CLU_010455_0_0_1"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021041">
        <property type="entry name" value="Maj_surf_glycoprot_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003330">
        <property type="entry name" value="MSG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02349">
        <property type="entry name" value="MSG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12373">
        <property type="entry name" value="Msg2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Major surface glycoprotein 2 C-terminal" evidence="3">
        <location>
            <begin position="935"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="779"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1022"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1100"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="61"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="779"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="828"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="872"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1022"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1108"/>
            <end position="1128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08822.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1151" mass="128745" checksum="268C6222466DCE7D" modified="2016-03-16" version="2">MPLRDKRWVEEVAQKEAAMAQPVKRQAAGQAAGNDEIKEEQVLGLIVKKEYEDNAKCKKKLEEYCAELKKIDGKLENVDAKVKGLCEDGKQGEKCKNLKDKVKKELDDFKTELEKTLNDITDENCRKCEEKCVLLEEADPSNLEEKCVKLRDRCYGQRRQEVTKEILLRALKEKVNDTNECKKRMKEICQGLSEYSDELVLICFNSDKTCKYLKNTHVDSCKPLETELEDKELVEKCQEYLEKCYFYGSSCKNTKCDKVKNKCKGKGIEYEGPKLDFSPVKEKPRFPEKIEVENLYKRLGAKGIIVGKPKYKTLQDLTLLLIKGRNGKDEGEKCKEALKDCESFKHLDYELEQLCEDKDKDNKCKELVEVEDRCTNLKLELYLKGLSTEFEESNESKYVSWEYVPKSVTKEDCRKFESECFHLEGVCTNEIGKACENVRVACYKKGQDRMLNRYFQEGLKGLIGDLELATENLEKCQKSVVGNYTKLKKDRRYFAKCHRPTKLCYELLDDVILQSEELEVVLNLRRDFPSKEDCVELKKKCEDLESDSYLNHEKCDTLNRRCEYLKVTEELKKRLLKRGDDALRTQGNCTAVLKKECEELSRRGKEDFSVSCALREETCSFMVEQTENECLFLKNNMDIGKIIEKIENGKRNETLVEELCTLFDPYCHQYIENCPDRLKKTNNAGRKGVCLELEEKCKPFFEKLKLENELTHKLKGSLSDETKCKETLGKHCTEWKKEGNQTLNSLCEDAKKEELCKKLVKKVKEKCPTLKNKLDNEKDELEKKKDEYEKAKQESEKFAKEAKLVLSRPEQDGQGGGSKAQDGSVPKPVGPPVQPPAPAQPTPGGVPAPTLAPPAQPTSGGAPLPVPPAAPAAPGAPSTPGTPAAPAGPAAPGTPSTPSTPPAGPAGPSGGTPGAPAGPPAPGGSTPSGTTNTSNVILVRRTFVSGEVSEPEKKAFVATARALELYLELKEKCKGLKGDCEFRKDCPKCETVCKEIDELCEGIEGLKVTPHHTVTSTATQTTTTTATTTTTTTTTTTTTTTTTTTATTTESVDGGKVTEECTLVQTTDTWVTSTSLHTSTLTSTSTVTSTVTLTSMRKCKPTRCTSDSSKETETQKEEEKEEEVKPNEGMKIRVPEMIKIMLLGVIVMGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNP4</accession>
    <name>M7NNP4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL23m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02915</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874956.1">
        <property type="nucleotide sequence ID" value="XM_007876765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNP4"/>
    <dbReference type="STRING" id="1069680.M7NNP4"/>
    <dbReference type="GeneID" id="19896602"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02915"/>
    <dbReference type="eggNOG" id="KOG4089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086423_2_0_1"/>
    <dbReference type="OMA" id="PFILYRG"/>
    <dbReference type="OrthoDB" id="275582at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL23M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059">
        <property type="entry name" value="RIBOSOMAL PROTEIN L23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="147" mass="18005" checksum="E1CFDBAAF8EFC5AD" modified="2013-05-29" version="1">MKPPFKLGKKPVYLPNIVFTLLRSPYLLPTQAAFKVPITVNKFDVKDYLFHIYRIEVTRVRSMICYRKRIRRKDYTKMLERTPSFKKVIVDMKEPFIYPKEPENLDPWNKRYTDGLQLWTQSKIFRRRRREPKIWKELRKVKNAIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP26</accession>
    <name>M7NP26_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein BIG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_02638</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BIG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874657.1">
        <property type="nucleotide sequence ID" value="XM_007876466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP26"/>
    <dbReference type="STRING" id="1069680.M7NP26"/>
    <dbReference type="GeneID" id="19896329"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02638"/>
    <dbReference type="eggNOG" id="ENOG502S6TD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062461_0_0_1"/>
    <dbReference type="OMA" id="QISYHAF"/>
    <dbReference type="OrthoDB" id="9985059at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037654">
        <property type="entry name" value="Big1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046756">
        <property type="entry name" value="VAS1/VOA1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28285">
        <property type="entry name" value="PROTEIN BIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28285:SF1">
        <property type="entry name" value="PROTEIN BIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20520">
        <property type="entry name" value="Ac45-VOA1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082238" description="Protein BIG1" evidence="11">
        <location>
            <begin position="27"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="V-type proton ATPase subunit S1/VOA1 transmembrane" evidence="12">
        <location>
            <begin position="234"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR08851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="282" mass="32522" checksum="BCD8EAAE84EDEC41" modified="2013-05-29" version="1">MARQCFTLYNILYFLVLLINIHKISCFEDTSPFIFYRSYSSYQSVFSDHVSTTLSGHAFQSLVRASIDCESTYYVFVLQPGLHADDLKHTVMPWIKKSIDIAPERLVVPYGYGDVDVENIIKYVEDKCYIYSIVIDSQSGEYPLLYNETEKILVVQFPPIVGTLEERRDLLTNHDLFLHYLLTSLPHGSKYSMIYISTPGPVIIQHRDASVYSTPMIPVKYNSNNPKGLFSRYSFFSEGIYMIWIILFILFPIFIIALTAISSIKISYGSFELKKDVIKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP32</accession>
    <name>M7NP32_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sel1 repeat family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_02800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874833.1">
        <property type="nucleotide sequence ID" value="XM_007876642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP32"/>
    <dbReference type="STRING" id="1069680.M7NP32"/>
    <dbReference type="GeneID" id="19896489"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02800"/>
    <dbReference type="eggNOG" id="ENOG502R8TG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_729818_0_0_1"/>
    <dbReference type="OrthoDB" id="5379420at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF160">
        <property type="entry name" value="ERAD-ASSOCIATED E3 UBIQUITIN-PROTEIN LIGASE COMPONENT HRD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR09027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="44270" checksum="065E0E415755D848" modified="2013-05-29" version="1">MYMFPKTLRKDLIQNYINEYRRKHKNIVFFEPFFRNISIFQVKYNQRNSESFLYKNNEIDYIKDIIGEKDLYIFEKKRKNIKKSYSEILNIFKHMNQLKNKFNRDILTAENIELVESVGKIIPFLVTADELFLITKIMLKTPVSKSILQEKLDLCKFSIQIASLKESDLATLYIAEKKMQLGTPDQIYQALRIYKTLSKKGNAKALLILGDFAIKLKDTQQAEKNYLKSIEKGNSDAMVAMAGLKRHLGKDAEAKFWFIRASELNNPKGHFGRSLYTTHEESLYYLLQAASNGIVEAAHNLADIYRREGNTIFSKEWFEVAAFSGFQASQINLARLYEQEGLFNKSLFWIREAQKQGGTIAEEARQYENILLKKYPYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPF1</accession>
    <name>M7NPF1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ELMO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873217.1">
        <property type="nucleotide sequence ID" value="XM_007875026.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPF1"/>
    <dbReference type="GeneID" id="19894990"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01293"/>
    <dbReference type="eggNOG" id="KOG2998">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_752519_0_0_1"/>
    <dbReference type="OrthoDB" id="67155at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF51">
        <property type="entry name" value="LD01482P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELMO" evidence="1">
        <location>
            <begin position="193"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="368" mass="44469" checksum="09F5688F81FACA4D" modified="2013-05-29" version="1">MILNDIIIHNIIRKRILNNSLKKKNKKDIFWVFLKDSICETIWRIRRIYKRIYRIVSHKTSICRILDSYISLEESSLKWGEERRKIWNIEENKKLESLVWNIYVELCLSVSVYSEWKDLLYRAGSLDSFEEIKFIDTVITSILLKKKIEYSYREDMCSKQCLCLRYSVMSIFFIQKEKKSIMQKCLTEVEYYQNQKMFEEIWDALIVSGKGIQNNKKNWVMLGFQGDDPSTDFRSMGIFGLQLLHHFVLTQNEYTKIMISESRSNHTDINLPWYSFALAAINILAYIIDLMNENRLERIFIQCYNYSVYVEETIKHLFCYTFISFHHFWRHQVSTKNVRTVFDFERCLKRFKKETRDDITMGNNMFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPM9</accession>
    <name>M7NPM9_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01363</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873292.1">
        <property type="nucleotide sequence ID" value="XM_007875101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPM9"/>
    <dbReference type="STRING" id="1069680.M7NPM9"/>
    <dbReference type="GeneID" id="19895060"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01363"/>
    <dbReference type="eggNOG" id="KOG4466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_970175_0_0_1"/>
    <dbReference type="OrthoDB" id="70376at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21964">
        <property type="entry name" value="BREAST CANCER METASTASIS-SUPPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01401">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="287" mass="33682" checksum="EBD403EC91992D40" modified="2013-05-29" version="1">MDLLAAVLRENDEWSDDSTEQLYPYSLNISASESKKDKRRRLLIEKLDHISRDFIMNRESYFHNQLLSLQNEMQQLHDGTHEEYLDSLRDLEEIREKELKSIQLMKDFLLKRAESEFEHDVELLEEEFTMSKATLKSRLLSHLFSRKRRLHEDKELLDIVNDSSFVLHSHSTTNPSLSPISITSTDKRKLRHRKGYVNNKSGLAEDISLFSSTIYNCKKNSENISSFLNSIEEQITKDRSREKQERERDKSSNDILGAKESEIMEDLIAIKQLTNPAKSERKRNTTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPZ8</accession>
    <name>M7NPZ8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ASX DEUBAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874535.1">
        <property type="nucleotide sequence ID" value="XM_007876344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPZ8"/>
    <dbReference type="STRING" id="1069680.M7NPZ8"/>
    <dbReference type="GeneID" id="19896217"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02525"/>
    <dbReference type="eggNOG" id="ENOG502S8M1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_774156_0_0_1"/>
    <dbReference type="OMA" id="EQDHINI"/>
    <dbReference type="OrthoDB" id="2289918at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028020">
        <property type="entry name" value="ASX_DEUBAD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13919">
        <property type="entry name" value="ASXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASX DEUBAD" evidence="1">
        <location>
            <begin position="90"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="358" mass="41656" checksum="B20F1243D2F17D4D" modified="2013-05-29" version="1">MLTLPPTENKNMIKIDNSSLEKLKEQDHINIDNEAINNTIVLENDKEIDKKANSLIDQKRKLNIDELENDSPVETTQLSANTLKRRRIDLWDIKQLLEYPKNKTISTNLDIFDSYDSPDYKQKQTEYLSILPTIDKIMKTEEEIEHAITNGFFENNLFLQDFIREFQDNFNGRYDERGTKNTFESRRYRSDSRIDSYREGQYEHHYNQKQQKVSAELRAGEATTLKLPQMAEMGLFVLGDIWKYSRTLGFKQRGKGREKIEIRKDLQLTGIDESTHSLTFLCPSSTNIYFIKGDPGISISNITTPTMLETQILDIDGRTAHSERPNGNAWKSIRVQRCGRDMGTLFEVRMKAFDLYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ13</accession>
    <name>M7NQ13_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_02538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874550.1">
        <property type="nucleotide sequence ID" value="XM_007876359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ13"/>
    <dbReference type="STRING" id="1069680.M7NQ13"/>
    <dbReference type="GeneID" id="19896230"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02538"/>
    <dbReference type="eggNOG" id="KOG1674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_860845_0_0_1"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF118">
        <property type="entry name" value="CYCLIN, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR09201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="37083" checksum="20ED5D8DA5A2009E" modified="2013-05-29" version="1">MMHCVHPVVIPRPEEEWRRLIVSSGIRKPRQISLYRHHPYLLAKLVSKSKQDILEDRDGPFAQYVVSPFLSSILESHAPEFIAQIVCLIWFETDLTLFSIISNVQSLNLLSPNSFPKEEFLSWNRGVLSSINISKNVIFLALLFIYRLKERNPMIRGKSGSEYRLLTIALILGNKFLDDNTYTNKTWAEITGISVKEIHVMEAEFLVNIHYSLLVSKTQWEDWQIILERLWTYSAGLMKIRFLRSLPCLSVPSDIALSCTNSLHLSQFMPIVSTQSVPLVPSWGYLKEYSVELKHKDCILGTSAVSLVKRTLLSRINMPCCKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ83</accession>
    <name>M7NQ83_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyl phosphorylinositol ceramide synthase SUR1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01015</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872928.1">
        <property type="nucleotide sequence ID" value="XM_007874737.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ83"/>
    <dbReference type="STRING" id="1069680.M7NQ83"/>
    <dbReference type="GeneID" id="19894713"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01015"/>
    <dbReference type="eggNOG" id="ENOG502QS3D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036369_3_0_1"/>
    <dbReference type="OMA" id="NRHSWSF"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF20">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE CSH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="37346" checksum="1CCFB64AF291CF9E" modified="2013-05-29" version="1">MKRLTLITVIVGLFLVVVLLNRSWFLITLLFENFELERISEWAVLYSDSYKVDTKKEAIPRIIHQTWKNETIPEKWEEAYDSCKKKHPNYEYIFWTDEKARDFIAQEYSWFLDQYDKYPYNIQRVDSFRYFVLVHYGGIYIDLDIECLKPLDPLLSYGAWLRITDPTGISNDVMGSVPYHPFFVFVINHLKSSSGNWIFPYLTVMATTGPLFLSVMLEKYMFFLSSDAFALEHVRIVTPDISNKIFKNFHGSTWHQKDAWFFFWLQRYWVFLFIGSIGITCFYSFYLFKRKLHQNFRYKKWIRFSDELPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQD0</accession>
    <name>M7NQD0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2433 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02064</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874045.1">
        <property type="nucleotide sequence ID" value="XM_007875854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQD0"/>
    <dbReference type="STRING" id="1069680.M7NQD0"/>
    <dbReference type="GeneID" id="19895758"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02064"/>
    <dbReference type="eggNOG" id="ENOG502QSJS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016583_1_0_1"/>
    <dbReference type="OrthoDB" id="3918848at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018829">
        <property type="entry name" value="DUF2433"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF11">
        <property type="entry name" value="DUF2433 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10360">
        <property type="entry name" value="DUF2433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2433" evidence="2">
        <location>
            <begin position="290"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="681" mass="77220" checksum="D059653695E817A1" modified="2013-05-29" version="1">MAIATRTLPQFLNVVNKPRQIRQKAEIESLQKPNGNFGVSSDKHVLISENCTRILCIADIRGNISFFNELCKKANAQYIIHTGDFGFYDNTSLDRINERTLRHIIQYSPLIKPYYRSKFTANSSIEFIRNTISHSELVISELPSFLSGEKELDVPVYTIWGSCEDVCVLEKFRSGEYKIKNLYIIDEHSSKCLNVGDIKLRLFGLGGAVIMHKLFDNGEGKTTIAGGQGTMWSTVLQMGELLHTANKVWDNSEVRVFVTYHSPGREGLLKQISLALKADFTISAGLHFRYGSSYNDFSVTPSTEYFLQKLATSRAQFMDVWETVKDEVELLIKDTQRSHLQSMINLVESMPQEDSLKNDILSQNREKIDAAFKNMWNFNLPDAAYGSVTLSISEGRISAETKAQGFNFSYRKNISQTNIDKQIFHRSIQTSDHSSAALQTQKSNVNTTQEKLKEHSQSQTKEPTHLSLTDTLSKNSTSLNSHNVQKTENMLSETSKTLNNQRKKENVDKETSDKSQLSKYALFISPCSTKEEAYSIFEKDIVDSITNISIRNCKGSSSKYAFVYFISKDNMNIAKKKTISRPGLRIAEADLGNNKSPKNNQGLRSNFQKSIISEINEVSRGIRTRGPRLKLSKSRRHNNLSKDSTNKSEELIKDKNNKRNNEVKNVIKDSIKNEKTLYTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQJ7</accession>
    <name>M7NQJ7_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00599</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DIF1/spd1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR10998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872496.1">
        <property type="nucleotide sequence ID" value="XM_007874305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQJ7"/>
    <dbReference type="GeneID" id="19894297"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00599"/>
    <dbReference type="HOGENOM" id="CLU_2455667_0_0_1"/>
    <dbReference type="OrthoDB" id="5399527at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013900">
        <property type="entry name" value="RNR_inhibitor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08591">
        <property type="entry name" value="RNR_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="89" mass="10109" checksum="E54DCB3D65F4FFF3" modified="2013-05-29" version="1">MNKDILPKGSKKQIILDETQLYNQLNNKSTLSEDLQTSLLNVGMRIRKAIASGYKTKQTDSPISKSNIDIIHPTYPSKNLSIKHKRRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQN5</accession>
    <name>M7NQN5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">DNA topoisomerase 2</fullName>
            <ecNumber evidence="5 16">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PNEG_00635</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 16">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15 16">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the type II topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="5 16"/>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872535.1">
        <property type="nucleotide sequence ID" value="XM_007874344.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NQN5"/>
    <dbReference type="GeneID" id="19894333"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00635"/>
    <dbReference type="eggNOG" id="KOG0355">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001935_1_1_1"/>
    <dbReference type="OMA" id="DVKPHMI"/>
    <dbReference type="OrthoDB" id="276498at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034506">
        <property type="term" value="C:chromosome, centromeric core domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16930">
        <property type="entry name" value="HATPase_TopII-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03481">
        <property type="entry name" value="TopoIIA_Trans_ScTopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03365">
        <property type="entry name" value="TOPRIM_TopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000003">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.30:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000008">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000004">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.670:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.199.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001154">
        <property type="entry name" value="TopoII_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031660">
        <property type="entry name" value="TOPRIM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034157">
        <property type="entry name" value="TOPRIM_TopoII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16898">
        <property type="entry name" value="TOPRIM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52040">
        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12 15 16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13 15 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15 16" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="19">
        <location>
            <begin position="553"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="20">
        <location>
            <begin position="799"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1502"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="1113"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1511"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="15">
        <location>
            <position position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00053943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EMR11038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1522" mass="173155" checksum="D19774B66A25BA99" modified="2013-05-29" version="1">MRHICCLKGLESVYKFCFLFKSIHCLGFGNLITVKGLNKVGMVIETSSDELDESFVLKRKYSVAAKNNKNKGFETTWSFKNDISSDKGIDKIVVEKRSYLKGEDAFNSRNMDISEKSGLVVNSDTKTASEIYQKLSQLEHILKRPDTYIGSVESTLQQIWVYDNNTNSMKYAQVSIVPGLYKIFDEILVNAADNKIRDPNMDTIKVEFSREKGVISIYNNGRGIPIQIHDKEKIWIPELIFGHLLTSSNYDDEQKKVTGGRNGYGAKLCNIFSTEFIVEPADKTTKKTYKQVFSNNMTKKNDPIIKENKKDEEYTRITFKPDLEKFGMNEIDSDLESVFKRRVYDLAGCLKNVKVFLNGERIKIKSFKQYIEMYLNSNGSEDNTKPLIIHDIVNDRWEVAFTVSDGQFNQVSFVNSIATTRGGTHVNYIVDQIVSKLIEAVKKKNKSAPIKPFQIKNHIWIFINCLIENPAFDSQTKETLTLKQSSFGSKCLLNDDFIKKVLKTSIMESILDTAQKKADQLMKKTDGSKKIRIIGLPKLEDANKAGTKEGHKCTLILTEGDSAKSLAMSGIGVVGRDYFGVYPLRGKLLNVREASHEQITKNAEINAIKQIMGLQHKKVYTSTSDLRYGHLMIMTDQDHDGSHIKGLIINYLESSFPSLLEIPGFLIEFITPIVKATKGSQEKTFFTIPEYEYWKESTDNAKGWKIKYYKGLGTSYGNDVKKYFSDLDTHLKEFHSIQEGDKELIDMAFSKKKADERKEWLRHFKPGTYMDHTLDKIPISDFINKELILFSMADNIRSIPSVVDGLKPGQRKVIYGCFKRKLKSEIKVAQLSGYISEHTAYHHGEQSLTQTIIGLAQTFVGSNNINLMKPNGQFGTRLQGGKDAASPRYIFTELSPLTRKIFIESDDALLDYLNDDGQSIEPVWYVPIIPLILVNGSEGIGTGWSSYIPNFNPIDLVDNIRRMMNGEELRPMHPWYRGFNGIIEKHGDKYKISGCIRQIDDTTVEITELPIRLWTQDMKEFLESSIVGSDKIQPFIKDYSEYHTDTVVHFVIKLTEKGMAESLSQGLEEKFKLTKIQNMTNMVAFDASGRIKKYDSVEEILLEFYTIRLQFYQRRKEYLVNELEKQYNKLSNQLRFVQMVINKEQEFLNKKRKDLLEDLKLKGFTPFPKNRQNFVDNTVETTLDTIENDDDISGYDYLLGMPLWSLTAEKVEKLLKDKLDKENELESLLKLTAKDLWNKDLDIFVEEWKESLTHDENLSSKVTNLKKNRGSQKLGMAVQKSSGKKAANIHTLSNIDNKKIVKKNSVSVKQTILPFTAINIKETESDPSKTSRHFSTKSTVSESVIAMKNDSADIQTHETTGKRPRTSVIVPSLKGNLLDDSDTDYMDDLVKKYTLNLPGSKGIASYIKPVSSSPKKMRIIPSTKSKARIKMPTLLDSSPESAIFSEKPAVKVHKKSKKNITKNFDSNDSSEADIVIKNEIMQRPRRQVAASARERVVAIADLEGDVETSDKSSSSEFNDLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQR3</accession>
    <name>M7NQR3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_02388</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874394.1">
        <property type="nucleotide sequence ID" value="XM_007876203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQR3"/>
    <dbReference type="STRING" id="1069680.M7NQR3"/>
    <dbReference type="GeneID" id="19896081"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02388"/>
    <dbReference type="eggNOG" id="KOG0173">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_3_0_1"/>
    <dbReference type="OMA" id="KQHLFRH"/>
    <dbReference type="OrthoDB" id="429533at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03763">
        <property type="entry name" value="proteasome_beta_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000005">
        <property type="entry name" value="Proteasome subunit beta type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024689">
        <property type="entry name" value="Proteasome_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF4">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12465">
        <property type="entry name" value="Pr_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <feature type="domain" description="Proteasome beta subunit C-terminal" evidence="11">
        <location>
            <begin position="230"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR09446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="271" mass="30031" checksum="5757EF9D249EB1EC" modified="2013-05-29" version="1">MIGSKTYIPRKGFNFDNYQRNLYLLSKDIALPPTISTGTTIVGVIYENGVCIAADTRATMGPIVADKNCKKLHKISSRIWAAGAGIAGDIDFVTSYISSQIELHALYTKRQPRVITALTMMRQYLFKYQGYVGAYLIVAGADPTGLHLFTVSAHGSTDKLPFVTMGSGSLAAMSVLETKYKPNMSRQEAIDLCKDAILAGIFNDLGSGSNVDIVVIEKEKTQYLRNYLKPNERAPKERSYKFERGTTAVIKKDIKKYVTTVDINDEMEIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQT9</accession>
    <name>M7NQT9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02211</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874194.1">
        <property type="nucleotide sequence ID" value="XM_007876003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQT9"/>
    <dbReference type="STRING" id="1069680.M7NQT9"/>
    <dbReference type="GeneID" id="19895904"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02211"/>
    <dbReference type="eggNOG" id="KOG0372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_0_5_1"/>
    <dbReference type="OMA" id="LCEIICD"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000002">
        <property type="term" value="P:negative regulation of DNA damage checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902660">
        <property type="term" value="P:negative regulation of glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001034">
        <property type="term" value="P:positive regulation of double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903432">
        <property type="term" value="P:regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="69"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="316" mass="36269" checksum="1E83483A470163A2" modified="2013-05-29" version="1">MILWSYLRLEGCAQILIIYLWVNYDIYIYYIGLYLRLKGDFVDRGFNSIETFLLLLSFKVRYPDRITLIRGNHESRQITQVYGFYDECIRKYGNANVWRYCTEVFDYLSLAAIVDGKIFCVHGGLSPTITAIDQIRLIDRKQEVPHEGPMCDLLWSDPDDISGWAFSPRGAGFLFGADVVKSFCRINQIEMIARAHQLVMEGYKIMFDGPLQKLNIDKNDENDENNGNNENNENIENGLNIVSSISECVLTPDDELDSGSIVTIWSAPNYCYRCGNVAAILELDENLEKSYKIFEAAKHDPTVMPPTKKPIVEYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQU6</accession>
    <name>M7NQU6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">mRNA cap guanine-N(7) methyltransferase</fullName>
            <ecNumber evidence="3 15">2.1.1.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 15">mRNA (guanine-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 15">mRNA cap methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PNEG_02068</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for methylating the 5'-cap structure of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:67008"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.1.1.56"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.56" evidence="3 15"/>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874049.1">
        <property type="nucleotide sequence ID" value="XM_007875858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQU6"/>
    <dbReference type="STRING" id="1069680.M7NQU6"/>
    <dbReference type="GeneID" id="19895762"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02068"/>
    <dbReference type="eggNOG" id="KOG1975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020346_2_2_1"/>
    <dbReference type="OMA" id="LITGDCF"/>
    <dbReference type="OrthoDB" id="10248867at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070693">
        <property type="term" value="C:P-TEFb-cap methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004971">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016899">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039753">
        <property type="entry name" value="RG7MT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189:SF2">
        <property type="entry name" value="MRNA CAP GUANINE-N7 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189">
        <property type="entry name" value="MRNA GUANINE-7- METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03291">
        <property type="entry name" value="mRNA_G-N7_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028762">
        <property type="entry name" value="ABD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51562">
        <property type="entry name" value="RNA_CAP0_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9 15 17" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="5 15" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRNA cap 0 methyltransferase" evidence="18">
        <location>
            <begin position="162"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="171"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>mRNA</name>
            <dbReference type="ChEBI" id="CHEBI:33699"/>
        </ligand>
        <ligandPart>
            <name>mRNA cap</name>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="17">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="17">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="17">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="17">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="17">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="17">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR028762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR028762-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR028762-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMR09481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="441" mass="51717" checksum="9E7D3E63197F0CCA" modified="2013-05-29" version="1">MTDKYLLKHPKDRSLENDSENCLLETNIKTKNQGLLEISCENASLDCQEKSFNTKKRPLHVDKELYLSEIIKDASEKALDFRKDLEPLDNAKSLVDKQEESHRKYKTPSIVKEQTSVDRKYERERIRMNQIKTCIQNQNVSDVVRRYYNERPEVGKKRRESSPIIGLRNFNNWVKSALIRRFTKEFPKNIPLIVLDIGCGKGGDLLKWSKAGVAGYIGIDSAEVSIMQARERFRKIKNLNFAAKFYVLDCYMNSLETVLPPDERKFDIVSMQFCMHYAFETEEKCHQMLSNVSKSLIRGGKFIGTIPNSDFIIEKIKKLKNGKKDWGNSIYRVQFINLPSSEFRPPFGHRYSFYLEDAVTNVPEYVVPFEAFRALALDYDLEMLYCKRFHDIFFEEQKDYEIKMLLERMNLVDNQGKRLISDDEWDTAGFYLAFAFEKRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQY4</accession>
    <name>M7NQY4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_00729</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872630.1">
        <property type="nucleotide sequence ID" value="XM_007874439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQY4"/>
    <dbReference type="STRING" id="1069680.M7NQY4"/>
    <dbReference type="GeneID" id="19894427"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00729"/>
    <dbReference type="eggNOG" id="KOG0106">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_34_2_1"/>
    <dbReference type="OMA" id="PREPAYP"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12339">
        <property type="entry name" value="RRM2_SRSF1_4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF51">
        <property type="entry name" value="SERINE-ARGININE PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="8"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="134"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="206"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="269"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="225"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR11133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="321" mass="38052" checksum="4BFDF0E2389844DA" modified="2013-05-29" version="1">MSRPASETRVYLGNLPRNINRRDIENFFYGYGDIAEIKLMSGFAFVEFKNSRDAKDAVQGMFCLFCLNTMTNMIKILVEIMEIVYVGVKVLLDGKRMLGERINIEFARGGRERRDDFRGRDMEVRYPRPRRTAYRVIVENLSQNVSWQDLKDFMRTAGEVTYADCSRDGSGKGIVEFETEEDLRAAIRKLDGVEFKGSEVVLREDLDASRPRSRSPRRNRSPRYRAYDRGYDRGYDRGYDRYDRRSPRYRRDDRDNYYRRDDYSSRRAFKDDRYSRAGSYDRSPLRDRSQTRSPVRSSKDFSPRESSSRIPMDDSVRDREY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQZ1</accession>
    <name>M7NQZ1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NEDD8-conjugating enzyme UBC12</fullName>
            <ecNumber evidence="7">2.3.2.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NEDD8-conjugating enzyme Ubc12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">RUB1-conjugating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin carrier protein 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_01862</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.34" evidence="7"/>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873833.1">
        <property type="nucleotide sequence ID" value="XM_007875642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQZ1"/>
    <dbReference type="STRING" id="1069680.M7NQZ1"/>
    <dbReference type="GeneID" id="19895556"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01862"/>
    <dbReference type="eggNOG" id="KOG0420">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_6_0_1"/>
    <dbReference type="OMA" id="CQVDFPD"/>
    <dbReference type="OrthoDB" id="10249039at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061654">
        <property type="term" value="F:NEDD8 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000005">
        <property type="entry name" value="NEDD8-conjugating enzyme Ubc12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="14">
        <location>
            <begin position="24"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="12">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR09672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="178" mass="20728" checksum="313DA65F9711F60D" modified="2013-05-29" version="1">MSMLKIHNIKELSDTEKKKHKISAAQIRVQKDITELLMPETMKIEFPDLDDFLNFYLIIRPDEGFYKGGSFCFKFNINENYPHDPPKVKCTQKIYHPNIDLNGNVCLNILREDWKPVLSLSAIMFGLQYLFLDPNTEDPLNKVAADDLRNNQESFQQNVQISMRGGYVLSEMFENVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRC1</accession>
    <name>M7NRC1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872160.1">
        <property type="nucleotide sequence ID" value="XM_007873969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRC1"/>
    <dbReference type="GeneID" id="19893987"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00289"/>
    <dbReference type="HOGENOM" id="CLU_562739_0_0_1"/>
    <dbReference type="OrthoDB" id="5386538at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="485" mass="56532" checksum="D86DA934CC831C47" modified="2013-05-29" version="1">MLPLFFFSRFSKNYKHYKKKLSQDKYSENSSSNYKKNIFESDQWLRSLRSLSVYSKNWRSSILKFKKRSFSFSSRSYLYSPEPSEQNNKDFFVDDIFRTNTATSFISGLSTNTYCSSRTYKIDGFKIFKSRPSVYLKGSIISTERPFPIEAELRRNSQDSYISSLADEMNTAEIRILLERDQRRRKRNKTSRKSQSMGFERVPDLTANTLLNRKISDDVVLNQLPMEHQHFNLISESRRNPIELSSKFNNNMPSVQNSNHSQNYHHKNINRNSTFNFISNNYNNEQKNKETALFSGKNTSLETINELDEQKDHSLVVNQDMIVYLDNNNNQETQFDSTHQDLSLFNDSIQNKFQNKKDHVFHPLFSSQSHVSQQTAHPVELSRHSQILEKNSIREGFAQTTDINLKTDNMGNCSLPTVFDSPFTTISSQESDESSLQTLTSKNLSHILNNYESSKNVYSYITDNFSELFALYNEVDFTPANTFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRC2</accession>
    <name>M7NRC2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01979</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873958.1">
        <property type="nucleotide sequence ID" value="XM_007875767.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRC2"/>
    <dbReference type="STRING" id="1069680.M7NRC2"/>
    <dbReference type="GeneID" id="19895673"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01979"/>
    <dbReference type="eggNOG" id="KOG1844">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_354153_0_0_1"/>
    <dbReference type="OMA" id="PRIHECA"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15550">
        <property type="entry name" value="PHD_MLL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19183">
        <property type="entry name" value="SET_SpSET3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044435">
        <property type="entry name" value="Set3/4_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462:SF3">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="6">
        <location>
            <begin position="209"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="521"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="793" mass="90049" checksum="55C6D241B05DBE5E" modified="2013-05-29" version="1">MGLESVGYDLDAGIIRCICGLEDDDGFTIQCERCYVWQHAVCVGIDQHHVPDEYLCDLCFPRTLDVKKAIEKQRRRREQELVHVKTNSSHSRKRRQFQYGLVKSKVHSLGSVKEKSLNATVKHDGSRKSRSGGRTFFSKDMESRFQIMEGSNGLNMNSDLLFDCNTEYSVIEHNLISSVDAEMYISLLLQDKSGMHVVLDDYFTSKQLPKTSIQPISDTDISSFLRFSLYSNQFIASGQIIKEFKGEIYLQDEYKVNSINHYSFLLAPKPFVYFVSDSKLCIDTRKYGTDSRFIRRSCKPNAKLITVASSSNFLIHIALCSLTEIQSGSEITIGWDWDMDHPAYYIENRERVPENDVKYSQELIYYINGLECACEIGKDCILFRLKQAFSSISKSSIKSNKKKAIFPLNNINHDIDNYDPDKSISQLKNDTNVVNKLRNVNEISESFVKNPSSCTDSNSNDLLSAREERKIKDILARIEKLEQEETQVIKKRKRGNGKSNENHKTYGHQHRTSLAVAIKQVCQQSGSSTTPSSSPKNDVSNTKSFPRRHGRIPSRIVRMQKHGKITNGILKDYSDDNDILPCKKMWMRRWIQENFKFDVEKVIKKDKQRLENGVVGFQDSVCSKTFKDMGINSVKCESRSSLSDMVLLEQLLPDMESSDKLSLSFTSPEPAISVPISEPSQLSDKLSTPSLFKPDLGFSSASESHMSSFTTIASPLTSELEPIQSTVLLTSPTSILGSFPKKISLSEYKKRRTANEELVVNDKSDDTFNIPEISVLPNNNSDFKIENSENTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRE7</accession>
    <name>M7NRE7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02018</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873998.1">
        <property type="nucleotide sequence ID" value="XM_007875807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRE7"/>
    <dbReference type="STRING" id="1069680.M7NRE7"/>
    <dbReference type="GeneID" id="19895712"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02018"/>
    <dbReference type="eggNOG" id="KOG1646">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046346_2_0_1"/>
    <dbReference type="OMA" id="KPRYKAP"/>
    <dbReference type="OrthoDB" id="10260596at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="212" mass="24319" checksum="634E5B3D91046E89" modified="2013-05-29" version="1">MEKRMGQEVPGDSVDDQFKGYVFKITGGNDKQGFPMKQGVLLSSRARLLLSKGHSCYRPRRDGERVRKSVRGCIVANDLSVMSLVIVKQGEKDIPGLTDVANPKRLGPKRASKIRRFFNLSKEDDVRRFVIRREVFPKGEGKKSYTKAPKIQRLVTPKVLQRKRLRLRLKREASEKQKQAAAEYALLLNRRIAEQKAKRAEIKKKRSCSLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRF5</accession>
    <name>M7NRF5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00337</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872210.1">
        <property type="nucleotide sequence ID" value="XM_007874019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRF5"/>
    <dbReference type="STRING" id="1069680.M7NRF5"/>
    <dbReference type="GeneID" id="19894035"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00337"/>
    <dbReference type="HOGENOM" id="CLU_2961853_0_0_1"/>
    <dbReference type="OrthoDB" id="4822at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47251">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47251:SF1">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="59" mass="6920" checksum="15A465602E3A1A9D" modified="2013-05-29" version="1">MTQFREERPSRSLPNPTAKTASAREALQSFFCELCDKGYQRISEYENHLSSYEHNHKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSC5</accession>
    <name>M7NSC5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SWI/SNF chromatin-remodeling complex subunit snf5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01775</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873743.1">
        <property type="nucleotide sequence ID" value="XM_007875552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSC5"/>
    <dbReference type="STRING" id="1069680.M7NSC5"/>
    <dbReference type="GeneID" id="19895469"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01775"/>
    <dbReference type="eggNOG" id="KOG1649">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018784_0_0_1"/>
    <dbReference type="OMA" id="IDADRYK"/>
    <dbReference type="OrthoDB" id="515064at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120262">
        <property type="term" value="P:negative regulation of heterochromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="325"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="325"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="64826" checksum="6B782EFEE190F974" modified="2013-05-29" version="1">MEAKCIRNTNEILNEFERRDEAYQQILLEQQERQLELIHQKKEELYRLSRIQKLRLSGIEGSIQVFGPGYSGYGNGWTGIKPRMLYPREQRAMKNKARRFKIPRETMLHQSECPELLVPVRIDVDSDRYRLRDTFTWNMYEMSISPEQFAEVLCEDFSLPPHPHFATSIAKCITDQVNEYQHHVLNDAFHATEMSEEFLEPNLPYTAYKDDDMRIQVKLDIIIAQYNLVDTFEWDINNPYNDPEVFAERMCLDLALTGEFKTAIAHSIREQAQMYTKSLFLVGYTFDGRPVEDEDIKTMILPTVSCIFRPLEMLNEYSPVLHELSESEVEKQNKENERDARRKRRQIRARRGIQLPEFNERPRTQRTPVVHSVLVPENFYIDQYGINKTPIPGLNDDDDFDSLLNERQRSPLLSRDIRTRTPVQQNAYSPSMSPSLPQRLILKFKIPRLKDFLVNMLDNKSHLSPSIGSSSLPQWLVIALDILRQRYPNDLFEGFVRQGNDPSDVVVRIRCNDCPGKLYIPGPSLTVENFEIHLKNRYHRTRVEQRLRNTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSE0</accession>
    <name>M7NSE0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00106</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uS19 is involved in the nuclear export of the small ribosomal subunit precursor. Has a role in the late stage of the assembly of pre-40S particles within the nucleus and controls their export to the cytoplasm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871963.1">
        <property type="nucleotide sequence ID" value="XM_007873772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSE0"/>
    <dbReference type="STRING" id="1069680.M7NSE0"/>
    <dbReference type="GeneID" id="19893804"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00106"/>
    <dbReference type="eggNOG" id="KOG0898">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097347_1_0_1"/>
    <dbReference type="OMA" id="KTHCRDM"/>
    <dbReference type="OrthoDB" id="10258210at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.860.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_uS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_uS19_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003121">
        <property type="entry name" value="PRK04038.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00059087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR11668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="145" mass="16718" checksum="AF3EA2B7C6A3F893" modified="2013-05-29" version="1">MDSTGEKKKRTFRRFTYRGVDLETLLDMSSEQLMELVHARARRRFQRGLKRRPMGLIKKLRKAKKEAPPGEKPETVKTHLRNMIVVPEMIGSVIGIYNGKVFNQVEIRPEMVGHYLGEFSLTYKPTKHGRPGIGATHSSRFIPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSI4</accession>
    <name>M7NSI4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Queuine tRNA-ribosyltransferase accessory subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuine tRNA-ribosyltransferase domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01494</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of a catalytic subunit and an accessory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873434.1">
        <property type="nucleotide sequence ID" value="XM_007875243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSI4"/>
    <dbReference type="STRING" id="1069680.M7NSI4"/>
    <dbReference type="GeneID" id="19895190"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01494"/>
    <dbReference type="eggNOG" id="KOG3909">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037350_1_0_1"/>
    <dbReference type="OMA" id="VPHIAHD"/>
    <dbReference type="OrthoDB" id="27601at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:tRNA-guanosine(34) queuine transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03043">
        <property type="entry name" value="QTRT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028592">
        <property type="entry name" value="QTRTD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050852">
        <property type="entry name" value="Queuine_tRNA-ribosyltrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="6">
        <location>
            <begin position="4"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="363" mass="42179" checksum="883957E1D5E2B41E" modified="2013-05-29" version="1">MKNLEIQTPNFIISSSRGSVPHITPDHLKSSEITGIYMALEDFIEYPAFNVKKEEKKDYSPSLRCISSLREFVPLSMNHYIVLGARRCPFNIIKPNSWKTMYIEASGGNKLINIKDIIDFYERLKPDMVISPVDIQPDNVTENKRFRRMIERSESWLIELLEKKLNSFIFASIPPVSKELYLLYFSILESNVSGIHGLALYNMEQSKFIPNSLLHLPLLLMEPIYSPHSILNSIENSIDLFTIDFISQSSDSGIAFTFQFPPSLSIEKNKRPLGINVLSEEYKAELLPLLQDCECYTCKYHHRAYIRHLLFTKELLGYVLLQLHNIHVINLFFSKIRTSILEGTFLDYSKLFKSYYQFFFPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSM3</accession>
    <name>M7NSM3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynein light intermediate chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00181</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872043.1">
        <property type="nucleotide sequence ID" value="XM_007873852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSM3"/>
    <dbReference type="STRING" id="1069680.M7NSM3"/>
    <dbReference type="GeneID" id="19893879"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00181"/>
    <dbReference type="eggNOG" id="KOG3905">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024211_1_0_1"/>
    <dbReference type="OMA" id="FKHNVID"/>
    <dbReference type="OrthoDB" id="27603at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035974">
        <property type="term" value="C:meiotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008467">
        <property type="entry name" value="Dynein1_light_intermed_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022780">
        <property type="entry name" value="Dynein_light_int_chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688:SF0">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05783">
        <property type="entry name" value="DLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="56508" checksum="9FBE74AE61719FB9" modified="2013-05-29" version="1">MNKSVLAQSTTEINTDDHLWSNLLNGVSRIKKAPSKYILLLGGGNRNAREWISSLKQAAIGVHTGRSFKENKEEIDSTYLMDYTYIEWMDQDQGERLAVIEVYLISERHVSCESLLLELFTQEFLKNCLICILLDWRNPWKWLEELYSWINLIRKSIENFKSLEAGNRVISDIIATWEHKIRTYSENAPWVSHDTNRNDQVAVPLEIGQYDQPLGLPFICVCNHSEHMLSIEKDELLKDEHFDFIQQFLRTILMKHGGALYYTSDLYPNTLNNLLYSILDCFSFSPQIYMDVNSPPKANVIDGNQIFVPPGWDSWGKIRIIRDGFDVERVAKAWDADLNFNTDKNKTLNSKKIFEEMIADCRKNDIFDISETNDFVTTIPYQEFLLNHLNIIETKLEAQENVPEDRINIANAYVASPQLNVGGIKLNAEEVDEKLKKLRDTRSESNSPVLTPEKCYKSPLKAISPLPAKEQNEVLANFFQSLLNRKKAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSV4</accession>
    <name>M7NSV4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00261</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872133.1">
        <property type="nucleotide sequence ID" value="XM_007873942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSV4"/>
    <dbReference type="STRING" id="1069680.M7NSV4"/>
    <dbReference type="GeneID" id="19893959"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00261"/>
    <dbReference type="eggNOG" id="KOG1533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037460_0_2_1"/>
    <dbReference type="OMA" id="ATHNYFL"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17871">
        <property type="entry name" value="GPN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000338">
        <property type="entry name" value="GPN-loop GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030231">
        <property type="entry name" value="Gpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF3">
        <property type="entry name" value="GPN-LOOP GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR11838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="317" mass="35953" checksum="3F725AD58D540F03" modified="2013-05-29" version="1">MPFAQLVIGPPGSGKTTYCHGMHLFLAALGRKSSVVNLDPANDHVLYPCALDIRHLISVNEIMEKTGLGPNGAVIYALETLENNFDWLKEGLESLGDDYILFDCPGQVELFTHHGSLREIVSKLEKMKYRLVVVHLVDAHYCTDPSKYISVLMLSLRSMLQMDLPHVNVLSKIDLIGMYGELLFNLDFYTEVQDLSHLLPYLENDSRLSSFTSLNASICDMIESFGLVAFETLCIEDKISMTKLLSVIDRANGYVYGTSEVAHDSLFSVAVRQGWNYEGNVHDVQERWITNKKQYDEHETKQWMEEATSINIHERIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSV9</accession>
    <name>M7NSV9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamate--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_01614</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873572.1">
        <property type="nucleotide sequence ID" value="XM_007875381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSV9"/>
    <dbReference type="STRING" id="1069680.M7NSV9"/>
    <dbReference type="GeneID" id="19895309"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01614"/>
    <dbReference type="eggNOG" id="KOG1149">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015768_6_3_1"/>
    <dbReference type="OMA" id="QAPRYDN"/>
    <dbReference type="OrthoDB" id="428822at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049940">
        <property type="entry name" value="GluQ/Sye"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311:SF2">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="An anticodon-binding domain of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="11">
        <location>
            <begin position="2"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class I anticodon-binding" evidence="12">
        <location>
            <begin position="327"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR10362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="471" mass="55036" checksum="88E7331B27EFCD49" modified="2013-05-29" version="1">MKGDFVLRIEDTDKTRIVKNSEKNIYKILRYTGIHWDEGPIVGGKHYPYKQSQRINIYLKYANILLESGNAYRCFCSIDRLEKLKKMSKIQGLSGTYDRNCMSIHMHESNERALKGDKFVLRFKIPEKYPVVHDIVYGDIDFSGPINIQRKIYDDPIIIKSDTFPTYHFANVVDDYLMNITHVIRGEEWLPSTSKHLAIYQAFGWIPPRFAHVSLLVNPDGSKISKRCNDTHIQNYIDEGYSSDALLNYVALIGWSPKTSNDVFTMQELIDRFSLDNLTKGTAIVMPEKLNFLNKQHFLRSTENEDGIKKIIKKIKPKIVSLYKKKILEDNDTERLEDEYIYKIILALRRKVQNINHLIESSKYFFVEPDYNEHILNEFKLTSKDLELTLKIIQELNKINIWISDEIISTITKIATTENIKIKKIKMILRFCCTASIVGADIIQIIYILGKKSVILRINKTMEWNKSFYHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSW4</accession>
    <name>M7NSW4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5745 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873576.1">
        <property type="nucleotide sequence ID" value="XM_007875385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSW4"/>
    <dbReference type="GeneID" id="19895313"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01619"/>
    <dbReference type="HOGENOM" id="CLU_513003_0_0_1"/>
    <dbReference type="OrthoDB" id="5407400at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044039">
        <property type="entry name" value="DUF5745"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19016">
        <property type="entry name" value="DUF5745"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5745" evidence="1">
        <location>
            <begin position="60"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="531" mass="61575" checksum="8FBC2D94FE1FCAF7" modified="2013-05-29" version="1">MRKNCLGHFENKKKYKKLLRELNKLLSKYSISDPIRLEEFSIDHMIRLYEALYDTEFPFTNKKNDSKKTQIKYLKFLLGTISHESLRIDLSYIDPVLVIKHDIKSIMNIVEVLVIIGHLQRLKEKITTRQEVNVEKESEEGSDSFVSDEILKCEEEADYLENNEASICSSLKDSQDIVHTPNSLVSSESVSVMSYFTNRANKVFNRIRSLNLDATQPTCVNEASKKNLVENKNIKDERKQAVIKNTNLCGKNKIDKISKHCRSIGTQTLLPYFSETPNSQISPLSSSPNASYQCSSKIRTCSIKKMMQKVSLNTWESQSSEDESLESDLFRKENIKTSINKKIEDIADFQSNFQQESLKRNDYYDQTLKDKIKIMPNNGENAHYHLLHTSHKVTPLRFRQNISQESSPNSDTTNIEFFKQKFRNGILGTDSPYTLYLRKRRKNALNALYAQRSHLEQNLKLSIKENRKIPAKHSKIKAKNIPYQKLYNRPLSDISFYSPSELKSQTSFFSNYENSITGLEKQLLSTKKLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSZ6</accession>
    <name>M7NSZ6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01498</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873438.1">
        <property type="nucleotide sequence ID" value="XM_007875247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSZ6"/>
    <dbReference type="STRING" id="1069680.M7NSZ6"/>
    <dbReference type="GeneID" id="19895194"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01498"/>
    <dbReference type="eggNOG" id="KOG2636">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027160_1_0_1"/>
    <dbReference type="OMA" id="GPKAFQK"/>
    <dbReference type="OrthoDB" id="2160351at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031774">
        <property type="entry name" value="SF3A3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021966">
        <property type="entry name" value="SF3a60_bindingd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF2">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16837">
        <property type="entry name" value="SF3A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12108">
        <property type="entry name" value="SF3a60_bindingd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="10">
        <location>
            <begin position="386"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="256"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="326"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR10226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="481" mass="57146" checksum="73340A0BF92046AB" modified="2013-05-29" version="1">MESLLERQRALHEDIERLEQAIADRLAQDNKKIKDRLSQEHDVAKFLDRIAEQSKKLLDIYTNEDKTQLLNETLTTSGSEFEEFYRQLREIKDFHRRYPNEKVENFEELYKKSPEEDEISKIFSGEENYGRFFDLNVLHEQWLNLKGVKYISYTKYLDFYDKFSSIHPRIKNENYFKYLVNLESYLESFYKRINPLEDHNKIISGIEADFEKEWNSGKLLELIVPMVNTGLISEDIFCDACNKNYSKKTVYDAHLTSKKHKKAEQAKKNKDKNDEKINNDTNEHHPLPKIDLLKKRILVKKEYFIQRLSSLLNSEREATKRNVVRKQTLTDRERQAELEAAENEETIIEEIKEDDRIWNPLKLPLGWDGKPIPYWLWKLHGLGVEYPCEICGNFIYMGRKAFDKHFMEWRHVHGLRCLGIQNSILFKEITGIEDALALWEKLKSDKKNSDRLLESTIEMEDDQGNVMSEKVYNDLKNQGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NT04</accession>
    <name>M7NT04_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit ASK1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PNEG_01127</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex ASK1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873042.1">
        <property type="nucleotide sequence ID" value="XM_007874851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NT04"/>
    <dbReference type="STRING" id="1069680.M7NT04"/>
    <dbReference type="GeneID" id="19894824"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01127"/>
    <dbReference type="eggNOG" id="ENOG502RZQN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_797277_0_0_1"/>
    <dbReference type="OMA" id="ARFWKQF"/>
    <dbReference type="OrthoDB" id="5573898at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990941">
        <property type="term" value="C:mitotic spindle kinetochore microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990537">
        <property type="term" value="C:mitotic spindle polar microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043622">
        <property type="term" value="P:cortical microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013964">
        <property type="entry name" value="DASH_Ask1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28200">
        <property type="entry name" value="DASH COMPLEX SUBUNIT ASK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28200:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT ASK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08655">
        <property type="entry name" value="DASH_Ask1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMR10412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="291" mass="32036" checksum="1FA6BA183D0C05F6" modified="2013-05-29" version="1">MDELSELERLEQKITLALYEIDANFNRCHRIVTTKILPIIEGYAEHSRRIWENSKFWKQFFETSANVSLSGYEELSQEISGLEETSIDAGDIGGITEGIIGGTSEANVIGDTPWTSTPLDISTPHATLPMTTSDAITSSPVGGSLTPLMSPATRIKKENPLLHRVLDSTWRLQVTPHIPFVQSSISSSSPAFTSWFTKANLETREEEDDLDASLPIGLSPPVTMQFSLPPSKLLKTPAREAARYVVDDILQTVGAEKSSTRPDIFARVDEESPLALVDQSGVNRVHTLIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTB8</accession>
    <name>M7NTB8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01577</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873531.1">
        <property type="nucleotide sequence ID" value="XM_007875340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTB8"/>
    <dbReference type="STRING" id="1069680.M7NTB8"/>
    <dbReference type="GeneID" id="19895272"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01577"/>
    <dbReference type="eggNOG" id="ENOG502SDJU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043321_1_0_1"/>
    <dbReference type="OrthoDB" id="2398441at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="36081" checksum="8C705298FB3B53E1" modified="2013-05-29" version="1">MEASSTLTVLNNGNNGKKTRVNDIVFQDMRLELPPYRPRLGSECLTQGGIPVIDLTVDTPSQSDHDPVENYGSNDLWNGRVIDVDSLPDRHSSSRHLDVYQTFPFESIDLDDILLLNHSISQSSRNCHIHSFPPTRRVTRQTTNQMRLWENQFFQTNDSFLHALINHMTPLNTRRANTSVRYSRTYPYYLSSRQNFSTTPIEYNLFTDHSNINAFSKKDTSITPHLLKGAPDAMKGFTRSLNKSQKLVCPNCIDELGVSDDFVKRSIWMGKCGHIYCGDCAKLFKSMKSKGPHSAICPVKHCNKVITGNHNLREIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTK7</accession>
    <name>M7NTK7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bms1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873246.1">
        <property type="nucleotide sequence ID" value="XM_007875055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTK7"/>
    <dbReference type="STRING" id="1069680.M7NTK7"/>
    <dbReference type="GeneID" id="19895017"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01320"/>
    <dbReference type="eggNOG" id="KOG1980">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009858_1_0_1"/>
    <dbReference type="OMA" id="MNLPRFK"/>
    <dbReference type="OrthoDB" id="119302at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000461">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF1">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22298">
        <property type="entry name" value="Tsr1_G-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="6">
        <location>
            <begin position="111"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="430"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="442"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="455"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="803" mass="93327" checksum="C5DF15F1DEDF5762" modified="2013-05-29" version="1">MTLNSPKIISKRYQPHKNLEKKKIKNQYLRVMVHKEVQNSHHHRSSMKKIHKKFKSKKKSKKRIERVFLGISPKKHTTLKADRKNTKKQIRDNKKEKIVGKNNVYTGSFGVSKLVVIVSLCTNVNPLKVVENLNKSIDIDTEDFVGVSDVFNIERFKQKLQYIIPKRDFLDIIDYCKVSDFVILLMSAKEDVDMFGEICLRSIQAQGISTVIPVVQHLDDLSSSKKKVDVKKSLLSFINHFFPEEQKIFTIDGLQDALNVIRMICVQIPSGIQWRDDRSYVLAENVTWKDLDDSTKGVLIIKGIVRSKPLNIDRLVCIPGWGDYQIDRIIILGLNEFNNKKKNNSMIEDVEETIIFPTENQDSLEELAPVIEDMEDMNGNANQEKKKRKSVHIDDYCYFSDDSDTIKRPRRLPYGTSDYQAAWILDSDSDASEDTSNMDVDNSSSNEHSNSESFEYNDEEDDSDNDQIDDDQSKMSIESLPEDENINDRQKEREEDRDFPDEVIVSSDVSLKKRFKKYRGLKNFRTSPWDPNEYNSDTPYYWRRIYKFGNYKTTKKRVIKQALNDGIKPGTCIIIEIRNCEKEIFSTYSSTSPFIIFSLLQYEHFLTASNFLITQNSGYELPVKSKDELILQYGPRRILVKPLFSQSSNTRSVNNVHKFERYLQKGRSSIASVVCPIFFGNIPILLLKSTLSGFSLVATGSFFNVDHSRIISKRVILTGYPFRIYKKIVIVRYMFFNSDDVEWFKPIQLFTKYGRVGYIKESLGTHGYFKAIFDRRINQQDTVAMNLYKRIYPSLGKIWRPQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUN8</accession>
    <name>M7NUN8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PNEG_00621</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872519.1">
        <property type="nucleotide sequence ID" value="XM_007874328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUN8"/>
    <dbReference type="STRING" id="1069680.M7NUN8"/>
    <dbReference type="GeneID" id="19894319"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00621"/>
    <dbReference type="eggNOG" id="KOG0600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_21_1"/>
    <dbReference type="OMA" id="ENMPGWK"/>
    <dbReference type="OrthoDB" id="28397at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070691">
        <property type="term" value="C:P-TEFb complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070693">
        <property type="term" value="C:P-TEFb-cap methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000562">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000514">
        <property type="entry name" value="Serine/threonine-protein kinase BUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF233">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="23"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMR11022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="479" mass="56525" checksum="4FDBEC314052B310" modified="2013-05-29" version="1">MSKMDTMNYKLRRFEGCSKPKDYERLEKLGEGTFGEVHKGRRKSTHDLVAMKRILMHNEKEGFPITALREIKILKTLSHVNIIPLMDIIVDRGDRKERKHGSIYMVTPYMDHDLSGLLENPKVNFSEAQIKCYMKQLLEGISYLHQNNIMHRDMKAANLLINNRGILKIADFGLARTFEEPFPNKDNSIIAREYTNCVVTRWYRPPELLLGEKKYTAAIDMWGVGCVFGEMYKQKPILQGKSDIDQLAIIFEICGSPTEFTMPGWQNLPRSESIKAFRTYFRTLEDKFSEYGSRMVSLLGHLLTLDPHKRFSALDALNHSYFHTSPLPADPSMLDTYDPSHELDRRKYREEKGYGNYLHPESKEKSMDTRNKWEGKIYERNPPSWIMNNQKLKNTKFKLKDNYTRENLNSYMHHKSSHPLYSHDQDKQSNFEYDTQKNANFYHEESQKRYYELYPPQFNQERNINDNTESSNYEFRSHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NW53</accession>
    <name>M7NW53_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_00384</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29535"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19518"/>
            <dbReference type="Rhea" id="RHEA-COMP:19519"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132517"/>
            <dbReference type="ChEBI" id="CHEBI:132519"/>
            <dbReference type="EC" id="2.4.1.260"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:29536"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872258.1">
        <property type="nucleotide sequence ID" value="XM_007874067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NW53"/>
    <dbReference type="STRING" id="1069680.M7NW53"/>
    <dbReference type="GeneID" id="19894082"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00384"/>
    <dbReference type="eggNOG" id="KOG2516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008917_4_1_1"/>
    <dbReference type="OMA" id="WWVEVRM"/>
    <dbReference type="OrthoDB" id="19039at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052917">
        <property type="term" value="F:dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF1">
        <property type="entry name" value="DOL-P-MAN:MAN(7)GLCNAC(2)-PP-DOL ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="359"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR11356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="513" mass="59854" checksum="F10B87D6954788E0" modified="2013-05-29" version="1">MLLNSLKNSYTLMKRQYIFIDIIIILLVLTHLFISPYTKVEESMNLQAIHDILFFGITREGLKNYDCFKFPGPVPRTFIGAVLTASIVSPLVFIKKLFFKKVSKSKIQYLVRGTLGIYNSLAIIIFRHKIIRHYGINTGLWYGIFQASQFHIMYYASRTLPNMFAFGIYTIAIKYFIEYKKKDILKGLFILTFTAVVFRFEIIILVITHAIYFWFSNKTTIKEMIKVFSFGGILGLFFSIIVDSWFWKKYFLWPEGMAFYFNIIEKKSSKWGVSAWHTYFSKYIPKLLLNPLFLILWGIALFKRPKDTINLLVPNISYVIIYSLQPHKEWRFIVYIIPSLTLVAAIGATWIYNRKYKSLVFTIAFLILIIAVLMTFSASLVMSLISSLNYPGAWSLKAFHNLDLSEKEKVHLDVYTCMTGVSLFLHDNEKIIYDKTEDITKLNSYDFLKTINWAISDASNFKLKGNWTIKDVISGYCGLEKVYFNNSIGILAKLWYPRVKMENKILILKNNEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWT6</accession>
    <name>M7NWT6_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872037.1">
        <property type="nucleotide sequence ID" value="XM_007873846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWT6"/>
    <dbReference type="GeneID" id="19893874"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00176"/>
    <dbReference type="HOGENOM" id="CLU_2292879_0_0_1"/>
    <dbReference type="OrthoDB" id="5377630at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="101" mass="11663" checksum="74B76F89A00DE828" modified="2013-05-29" version="1">MVNTAFDVFLLELDTLKESASSILFPSINSSLTSENGSGDEYTNEIFWCNKAEKLATLEQEIHEYQSNKTLKNIEKTLDKLQYQIDQILQIHFSETRNTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWV2</accession>
    <name>M7NWV2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ML-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00074</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871931.1">
        <property type="nucleotide sequence ID" value="XM_007873740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWV2"/>
    <dbReference type="STRING" id="1069680.M7NWV2"/>
    <dbReference type="GeneID" id="19893772"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00074"/>
    <dbReference type="eggNOG" id="ENOG502QSVZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010226_1_0_1"/>
    <dbReference type="OMA" id="FQAQAFI"/>
    <dbReference type="OrthoDB" id="5212126at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF2">
        <property type="entry name" value="FLAVIN CARRIER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082733" description="ML-like domain-containing protein" evidence="8">
        <location>
            <begin position="24"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="541"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="9">
        <location>
            <begin position="25"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="767" mass="87462" checksum="393CC180AD7E681B" modified="2013-05-29" version="1">MKFFIFGFILIFFWNGLISCVNAKRGIGTRSMSTCMENSGLIATVFRITYYPDLEKMVYRVDGMTSIEGEVIVNLIIMAYGIQVLNKTIDPCILKMPQLCYLQPGPLTQIEGESDVPVDITSHIPGVVYAIPDIDVYVKVMIYSKHSGDLKACVQVTMTNMMTVNVKTVGWISGLIALSALIVSAIAWENGNSNTAHHIATNAFALFSYFQGQAMFGMMSAKMPPIVRAWTQNFQWTMGIINLGFMQKIFTWYIKSTGGLPSYLHSSSLEHSIILEKRDFHLEKRASNNFNDPKYVFRGIHRVAYSEQIETTNLFMTSFSFFLIMVFIMLLGFALFRILIHYSPKIQWIRNDRFFGFKNEWKDLLKGTMYRLLLIGYPQLSLLCIWELISRDSIGAMIYAIISLIVVTGLLSYAAYWVIVLARRSLKFHKTAAYILYSDSGILTKWGSLYIQFSASAYYFIVPLLLFILLRSFFIALCQSNSLVQAIGYFVIELVYFFLIVYIRPFLDRKTNIFSITVASIDLLNSIFILIFANESRIYSIVVAVFGIIFFIINCIFALILLVLLIIVSIYALVSENPDILHEQMQDDRSEFIKSKTNFSNLELNLSNENNGSNFKEMSTKNHALSSYDRSYSLAGKVNNTNSNQSGNFLSSYDLIANYISQNPSITAPQPPFKSSMRSSNDSLFKDLQGNKDNMDVEYVPYRELNIDSSMANDRQFSNIHRSRYIPDQNSHAISFSDLQSRQYIPGAPKKTRNYGLYYNTYTSRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NX17</accession>
    <name>M7NX17_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872001.1">
        <property type="nucleotide sequence ID" value="XM_007873810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NX17"/>
    <dbReference type="STRING" id="1069680.M7NX17"/>
    <dbReference type="GeneID" id="19893838"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00140"/>
    <dbReference type="eggNOG" id="KOG0191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021868_1_1_1"/>
    <dbReference type="OMA" id="IFVYFYD"/>
    <dbReference type="OrthoDB" id="72053at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052250">
        <property type="entry name" value="PDI_TMX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426:SF1">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082739" description="Thioredoxin domain-containing protein" evidence="6">
        <location>
            <begin position="18"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="561"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="42"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR11706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="607" mass="71943" checksum="958020963F94334B" modified="2013-05-29" version="1">MLLKEFFLLILFLYTSARIKAYNSIGDRARFSSHNLSGEEFSVFFSKLPYLSSKYSVDLKPESFYSRTSSLWLIRFYSSKCSHSKLFEPYWIEATKKAFDYAENSNFYFGNVDCFLYEKLCSEFGIKCYPKILLFEDGQLKEEFKLSDISEENIHEIISYMKKKTEKISLSQTSKRILERSVNDLKLRSESKRFFVNPNGKSIDLTPEMFSQLIHTGKSGWFIKYILPYCPYCKEMEGDWIRFASYMKGLLNIGEIDCSKYPSFCKKMGISGVPMMFYYKGNYNIKYIGPRKTNSFRKFAQKVFLSRSALVQNFDTYSKYSSRFLIFFIYFYHQLTPENIDILDWMSIVLIGKAPLLRIPNSASFIKESSINTPSLLVFREGITFSYPFRDLKDLRNKTQIFNWMRSSWLLLFPELTRHNFNDIMRHDFVILVILYNTEEYKAKKQEIKDTIYTWKTNYSSNFTNKRSKQPYYSIQYAWVNAKLMRTWLHKAFGIKYGKTKVIILKNDVFWDKNIDGLYIQSNKKDILRTLNAIMQDTDKIKPSNLTKQIALEKPRPKKSYYYVLIIVFIITTILLMISLGLILKKIREKRQKENGKNEEPLESRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7P2P0</accession>
    <name>M7P2P0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_03587</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875681.1">
        <property type="nucleotide sequence ID" value="XM_007877490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P2P0"/>
    <dbReference type="STRING" id="1069680.M7P2P0"/>
    <dbReference type="GeneID" id="19897274"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03587"/>
    <dbReference type="eggNOG" id="ENOG502QQMM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_298613_0_0_1"/>
    <dbReference type="OrthoDB" id="207120at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057402">
        <property type="entry name" value="AIM3_BBC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25459">
        <property type="entry name" value="AIM3_BBC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="3"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="238"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="327"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="477"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1006" mass="114480" checksum="E7EE4C6586F30557" modified="2013-05-29" version="1">MKLNNMQCQALYDYTSEYPEDLKFNAGQVIDILGVENTDWYIGQYIDATGYRSIGIFPKNYVQLSEETEGNEINMKDIVNNTEDISKNNKDEHTKSDRGEKSDTLSSKESESKKSVKKSFREILDSFNTPKEEDIPSTTNRHSYIQKPRMCLSNIYINNTRQTETHNTENLQKDISSNVPEQNILQLGSLKNRILALKNIKFDNQESLEANASNNNLTLEPILEENTKKHNIAPKNISSEISSNSSHSFKPNKNAPSHEPRDPKQEKNEKDNLINDEKKTSETISSKNNDSSIEEELARRAAIRERMAKMSYAGMNMHMVLGISKQESTYTGPKSSPKRTSFSHNEDKSQITTPVFSVPIVPSSPTKQPNRNYQLDNFSKSDIQNTNKEITIQNNSSEFVKHSLSHLHLSTPLKYHDTVSVSENDISLKDDNEDLEKSAIYYTPVPIVEPFSVFLSKNSKNNSPILSNKTISPILIGQSPENFEPSKLPQRPLKDPPSIPEHPYSTHSSELFNNIDLSTQKQSTPCRPAKPLFISKSSLTSKCTSPILSQHDNRLSHTSNISSELGFISEEASKSQLSCSDFKDKLEYTYILEEKQFCIDEDKLEENKNSRNDVYRNDISSSVVYEKNANDDISPISLTSSYVIQNIADNNKVKKDINNNMFAQTDERPASNLQYRYSKYPGSPLQQNYSEEYFSFCSPASDISETDKKSNKYQVSAEKPYIHNQLSINQLRGAHYLIDQRNINYDPFNQVEYIAHNIDLEKDTLWWTLPNALPSIFQNRKDILLKFFESSHLLKDGNTIITKEIRILFHDYSETHILVTFNKKNPENANLKQIHQPSPIKPNQNQLEIAYEKFGTQIANLASLHFGITVGDGSPFAFVQDIISNIPDALPSTGVRAYGALIYRNRANASTEQRDEIKTGDIVSFRNAKFQGHKGSLYTKYNISVGNPDHAAVIMEWDGTKRKIKVWEQGRISKKVIQSSFKIGDLKSGEICIWRVMSKSWVSWDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7P4H6</accession>
    <name>M7P4H6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA exonuclease 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02910</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874950.1">
        <property type="nucleotide sequence ID" value="XM_007876759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P4H6"/>
    <dbReference type="STRING" id="1069680.M7P4H6"/>
    <dbReference type="GeneID" id="19896597"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02910"/>
    <dbReference type="eggNOG" id="KOG2249">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022453_2_0_1"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06144">
        <property type="entry name" value="REX4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000007">
        <property type="entry name" value="Interferon-stimulated exonuclease gene 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037431">
        <property type="entry name" value="REX4_DEDDh_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="10">
        <location>
            <begin position="106"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR08735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="261" mass="30188" checksum="5FE773AE22A19062" modified="2013-05-29" version="1">MQLDHYTPSCNWRSLQKSLGDSKKIQKKTKKTPSIKPNKNKALKNNVKIKESSEAFFSFLKPGFCRQKSLSDEHIIQSEKETNNTQKTRFMNEVIFIYTYKSSIGRYIALDCEMVQVGPCDRKDRVLARISIVNYHGNIILDTFVKPKERVVDYKTWISGVTHSDLEKAPSFEEVQRKVSDLLKNRILIGHAIKNDLDVLFLSHPRKDIRDTSRFKPFKAYSKGRTPSLKRLAKEILNISIQDKTHSSVANIHHFFLTTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7P504</accession>
    <name>M7P504_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02711</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874736.1">
        <property type="nucleotide sequence ID" value="XM_007876545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P504"/>
    <dbReference type="GeneID" id="19896402"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02711"/>
    <dbReference type="eggNOG" id="KOG3053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045297_0_0_1"/>
    <dbReference type="OMA" id="CLQSWRH"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347">
        <property type="entry name" value="RING/FYVE/PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347:SF1">
        <property type="entry name" value="RING_FYVE_PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="5">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="238" mass="28025" checksum="3221B7829F3052B0" modified="2013-05-29" version="1">METASREEDEKDIPICRICYGGVEDQSTLGRLISPCRCQGTIKWVHVNCLLQWRIKSKSSKSYYRCDQCHYEYLFLRPQLSAILVSYPSLLLCTVLVFIGLSFIAGFIVKLIFYFGFEYIVDFLFYEPIPIPESFVRPRTLWQIFSVIDTTHFILGFISLGAIGTIQLLGPIRNYRTLFRGQRRRHLRHFQDGIMIFYFTGMLKIAWNLYKKIQTWSRYWLEQLGNRILEVGEQPSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7P5H1</accession>
    <name>M7P5H1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="17">2.7.7.1</ecNumber>
            <ecNumber evidence="17">2.7.7.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PNEG_02473</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury. May be involved in the maintenance of axonal integrity. Also functions as a stress-response chaperone protein that prevents toxic aggregation of proteins; this function may be independent of its NAD(+) synthesis activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 17">
            <text>nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the eukaryotic NMN adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="17"/>
    <dbReference type="EC" id="2.7.7.18" evidence="17"/>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874482.1">
        <property type="nucleotide sequence ID" value="XM_007876291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P5H1"/>
    <dbReference type="STRING" id="1069680.M7P5H1"/>
    <dbReference type="GeneID" id="19896166"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02473"/>
    <dbReference type="eggNOG" id="KOG3199">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033366_0_1_1"/>
    <dbReference type="OMA" id="HFDYELN"/>
    <dbReference type="OrthoDB" id="422187at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09286">
        <property type="entry name" value="NMNAT_Eukarya"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000221">
        <property type="entry name" value="Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051182">
        <property type="entry name" value="Euk_NMN_adenylyltrnsfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045094">
        <property type="entry name" value="NMNAT_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00482">
        <property type="entry name" value="nicotinate (nicotinamide) nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039:SF0">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 17" id="KW-0520">NAD</keyword>
    <keyword evidence="10 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 17 19" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7 17" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="18">
        <location>
            <begin position="51"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00093425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMR09130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="270" mass="31718" checksum="831FADFEEFBD8BD8" modified="2013-05-29" version="1">MEKQCLDYRDTIDIFDEKNSIYFPSIDGYEFCDRKLRLEMQDDTKIPLVLIACGSFSPITYLHLRMFEMASDVACKKWGMEVLGGYYSPVADDYKKEGLLESKDRLQMCKLACEETSSWLMIDAWEALQKRHTRTAIVLDHFNYEINKIRGGVFIKTGEKKKVKIMLLIGSDLLQSMMTQPVWEERDLHHIFKYYGCFVIERGEIDVLSEISKHNILSMYQNNIIVVKQWIYNDISSTKIRFCIRNGLSIKYLLPDSVLQYIYQNKLYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6B6</accession>
    <name>M7P6B6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sfi1 spindle body domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09405.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613299.1">
        <property type="nucleotide sequence ID" value="XM_019757741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P6B6"/>
    <dbReference type="STRING" id="1069680.M7P6B6"/>
    <dbReference type="GeneID" id="19896043"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02350"/>
    <dbReference type="HOGENOM" id="CLU_370925_0_0_1"/>
    <dbReference type="OMA" id="WDRATVR"/>
    <dbReference type="OrthoDB" id="5360338at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013665">
        <property type="entry name" value="Sfi1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08457">
        <property type="entry name" value="Sfi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sfi1 spindle body" evidence="1">
        <location>
            <begin position="218"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09405.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="826" mass="100826" checksum="BD6375837C87A577" modified="2016-03-16" version="2">MHKFTADLNLLYEIVVVADTSKQRGSFLAIFEAYDTVLKRKNIDSTNDRVYYKYILKLVQIQGEGWEYKFKSLIKNMGIDFRSIKKTTPENSILDHKNRDTDHTFTPNYEESSKSLKDFFYSSDETSNSSLASQITKSSPVTTKSLQKENVKISTYNNNIVKNAKHAEYIYNERCILIKQKYFKIWVRRTEDIFNYFQSMYSKAILHDSYILSFQALKIWHQKSLYLKKTKRNAENAGNYVLMEKSFIKWLKMLYIKKKKHQQLYNFILMKIFLNAWRKIWIMQYKIAALHLLSFPFSIWKKKLLIQKNIMYKAIEWQRQHLLKHIFISWFTKTYLDKLILNKSSKKKYDTFLLWKSQLQLIYTKNETAIKNYSKKIINYYYKLWFQKSKKIYKNMIKAIALSNNMNIIKIFHTWDIKYKIEISKKEFLSFKNKSLCKKYFLNWKKKTENMQLASNFFNYTLLRLTFINWRQVLYLNILLIKLENKLRRRIIYKWILKERLILLLRVRGRRLYYLTFYLWKKYFRTLDDRNILLISILKNKIDRRIKIVTFLEWIEKLTLLNKNKKNAKGIYSANIKRNIINIWRKKNINIQENNLTAKYKSNYFYTKHSILHWKGKFHKRIKSREQHVNLFIYNHNLKLCHRTIMHWQYYFKSIILNYDIALKFRASKYQCLIIQFFSIWTNKYKNLDIILIQTRKEKNLKNIKLYFIKWKKKQNIILSMSNNALVILIKKNHTLIKKYIRKWELHILQLRGPEIQAHLFKKKQNELFMKKTFYFWKHQLKKKNVPEKESTKNDNFSLFGNSSNIISYNNFALSPFLNKLRFTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6K0</accession>
    <name>M7P6K0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TATA element modulatory factor 1 TATA binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02098</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874078.1">
        <property type="nucleotide sequence ID" value="XM_007875887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P6K0"/>
    <dbReference type="STRING" id="1069680.M7P6K0"/>
    <dbReference type="GeneID" id="19895792"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02098"/>
    <dbReference type="eggNOG" id="KOG4673">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_378166_0_0_1"/>
    <dbReference type="OMA" id="NWESIEF"/>
    <dbReference type="OrthoDB" id="74178at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052602">
        <property type="entry name" value="Growth_transcription_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022092">
        <property type="entry name" value="TMF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022091">
        <property type="entry name" value="TMF_TATA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515:SF1">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR TMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12329">
        <property type="entry name" value="TMF_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12325">
        <property type="entry name" value="TMF_TATA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA element modulatory factor 1 TATA binding" evidence="6">
        <location>
            <begin position="610"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="195"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="291"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="423"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="628"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="733" mass="85669" checksum="B8BEAA7E65E34B1A" modified="2013-05-29" version="1">MWSDFLKKAINNVEQFKYDTKGLSNSLSTTLEKSPTKSHQQSPRKPMQERLSEIVTSVQNSGRFLESQSLIQEKLDVMSAYLHSIRLNQKKKGKKTEWCPVYETDEITENRCSLVFPASMPNTIKKEEINDADLKKAKKKSHIDTGESSVLPNQFVDLDIISLKHAIDEKDRKIHILLEEGEELSKKELKHLSIIKNLRSKIERDGKDINEMKNKTKKLESEVTDLKKKLKNVSENNKLLSNRLKEMSDLEKEFNLLKIEQSRFEIEKNNELKNLEDETIAIKETMSLQHLEELEIEKSKSHSLLDKLNEANINLSLLEEKSKSEINSLYSLLENERKDFFIKEKSYIEEISVLERKVEALRYELEEVSHNANSNFHANLLQQNEALQAQYFTAFQHWKEKESDILIKNALLQEENEKYLKIINKETLKSKNINEKMEKLKMTLFDNENILKETRLLNESLTKKVSKLEETIVKINSAHKNELKELKLLFETQCKVGKKPKLTDNEIPLTNNSFDLQYKDYDILKHNEAKSSIFSDSMDDICYQKRHSGDLFVQNILPCLPTTSKNYTNNNKNDDVNDSNTDVYFDNESVQSVSALPILHSFNFSDHDISMSKIRPNINIILQLSLSIQRLKGQLSMKHDEINQITRQRDEARNECVQLMIEAEKNKELNNKICILEDKLKELNERYEQCLELYGEKSEKEKELKQDIADMKEIYTQQIEELIAKFNHSQELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6W9</accession>
    <name>M7P6W9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL34m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02219</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874202.1">
        <property type="nucleotide sequence ID" value="XM_007876011.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P6W9"/>
    <dbReference type="STRING" id="1069680.M7P6W9"/>
    <dbReference type="GeneID" id="19895912"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02219"/>
    <dbReference type="eggNOG" id="KOG4612">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2307211_0_0_1"/>
    <dbReference type="OrthoDB" id="431691at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3980:FF:000001">
        <property type="entry name" value="Mitochondrial ribosomal protein L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_bL34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_bL34"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL34M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN 34 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="100" mass="12196" checksum="5FA3AB406E32BB21" modified="2013-05-29" version="1">MTPNMILMKNLYRKTIKKHETVLNEKNSRFQFEKSSPSLFSSPTKLWILNIKRFRTYGREYQPSNRVRKRRHGFLSRKRSASGRRILARRITKKRKYLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7P7A6</accession>
    <name>M7P7A6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873906.1">
        <property type="nucleotide sequence ID" value="XM_007875715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P7A6"/>
    <dbReference type="STRING" id="1069680.M7P7A6"/>
    <dbReference type="GeneID" id="19895624"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01930"/>
    <dbReference type="eggNOG" id="KOG2049">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004133_0_0_1"/>
    <dbReference type="OMA" id="THALEMK"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21372">
        <property type="entry name" value="cwf21_CWC21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000237">
        <property type="entry name" value="Pumilio homolog 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF13">
        <property type="entry name" value="PUMILIO HOMOLOGY DOMAIN FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="515"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="537"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="573"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="609"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="646"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="682"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="718"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="754"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="790"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="502"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="906" mass="102674" checksum="0F3BE0E58509493E" modified="2013-05-29" version="1">MSISSGSPDNKFRKNSIENGNDINKKSELSFLNAYIPTKHLSVSSPFKHNISVSTFSTTDHEKIYKNHNLSDSSKNRNEGVDNYMRKDYTSELSLSSINKTHALEMKRQQYELQRIEHRRRFEKEMKLLELRQKRDEQALLGYDDDTIGSISVNSAPNTPPNLQIPSDTRMYFTSVPRLTSPLQFYEQFHNGGQLATPPSDDNSRSSQFSESHKELGESEILMKNLNINSYNSNNKSLSVLQGNNENYNIFHDEFSNNRQSYLHQTSTFENNMKNKEKTSPFVKKYLEMETINDNFPILIKRNNFPEMFTSSNTTLNLTRSTHQDSHEKFIKCESQNTQKDTNLVYSSLDASCGHPSFSLKDENLVSPKFHSIKEKDSSNQNLQSSMNINYTSFTSKNQPSLSTSSASTAFNYLKPKSENYSESNKQSNSNSNNVSQSQYSIGFLLPNAKSPLNVPILPSTVSSLHSSNIYGKYGIMNLPSSYQSATYGSYPLYSASNQPSTETSQTSFTYANNRGTNHKKNANSDGNRFTGAALEAFVGEIYSLCKDQHGCRYLQKKLEERDPRRTSIIFMETYPHAVELMTDPFGNYLCQKLLEHCNDEERTTIVRSVASDLIPISLNMHGTRAVQKMIEYLSTPEQIQIIINALNSNVVTLIKDLNGNHVIQKCLNKLSTNDIQFIFDAICSNCVEVATHRHGCCVLQRCIDHASDSQKIQIAKEITNNALNLVQDPFGNYVVQYILDLGDARFSEPLIHRFIGNVCLLSVQKFSSNVIEKCIRMAEPPTRSLLIQELPRKIASLIRDSYANYVIQTSLDYADSIQRKQLEDCILPLLPSIRSTAVGRKIAMRIEKNNSLCGNNVTGVLDNSSRENSNPHHTNGLVSTSKNIHMYLPTLHHCSNYNKQEYSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7P8R7</accession>
    <name>M7P8R7_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_01506</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Forms a heterodimer with SLX4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the SLX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873445.1">
        <property type="nucleotide sequence ID" value="XM_007875254.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P8R7"/>
    <dbReference type="STRING" id="1069680.M7P8R7"/>
    <dbReference type="GeneID" id="19895201"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01506"/>
    <dbReference type="eggNOG" id="KOG3005">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030739_1_1_1"/>
    <dbReference type="OMA" id="CASHIVC"/>
    <dbReference type="OrthoDB" id="24645at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10455">
        <property type="entry name" value="GIY-YIG_SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03100">
        <property type="entry name" value="Endonuc_su_Slx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027520">
        <property type="entry name" value="Slx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048749">
        <property type="entry name" value="SLX1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050381">
        <property type="entry name" value="SLX1_endonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208:SF10">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21202">
        <property type="entry name" value="SLX1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GIY-YIG" evidence="11">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="237"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR10235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="330" mass="38751" checksum="2D946948DD3F2DA2" modified="2013-05-29" version="1">MHFFPPFYGCYLLKSETTKRTYIGSTSNPFNRLRQHNGEIVSGAQKTVKGRPWNIICLVYGFPSVVSALQFEWAWQNPYKTIKIQKEEKNRLQTDLNHNCDEEVKFPKQGSYVSIKRRLFILYNMLTMNAWKRWPLKIRIFDERAKKLWETLDDTINTKIMPCMTLEYDIILDSTKRKKKININNSSNIENNDLLNPEEMGNKGYHALKKINIIIDEMSQIAFRIFEKIKEKNNNICIICRNICEFPELDSDDAALIYSQLIICPIEDCLHVFHLLCLAKSIQTSETENDVLISRYNCPSCQKSIIWGDCIRLQYCILRKINANLEEIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7P9I4</accession>
    <name>M7P9I4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2'-phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.160</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01239</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:23324"/>
            <dbReference type="Rhea" id="RHEA-COMP:11106"/>
            <dbReference type="Rhea" id="RHEA-COMP:11107"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:76596"/>
            <dbReference type="ChEBI" id="CHEBI:82883"/>
            <dbReference type="ChEBI" id="CHEBI:85027"/>
            <dbReference type="EC" id="2.7.1.160"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.160" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873160.1">
        <property type="nucleotide sequence ID" value="XM_007874969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P9I4"/>
    <dbReference type="STRING" id="1069680.M7P9I4"/>
    <dbReference type="GeneID" id="19894936"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01239"/>
    <dbReference type="eggNOG" id="KOG2278">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RHGASQM"/>
    <dbReference type="OrthoDB" id="419694at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="entry name" value="RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="223" mass="24905" checksum="50B57182C55D906A" modified="2013-05-29" version="1">MSIHDENWSRKLCKVLRHCALDYGFHMSSDGFVSVNALLAHNSFKGLTVERLKKIVDENEKSRFTLRMDSETGELLIRAAQGHSIPLHDDLLLKRVTCRELLPKITVHATTRKKCIEIFKSGGLCAMKRNHIHLVSYPECLGNGSSSQIRASSDTLILVDVQTAFDHGISFFWSTNNVLLTPGAPDMPGWLSTRYLKGAITRSGKPIELSLYSSIFDSSEKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAA4</accession>
    <name>M7PAA4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_00909</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872820.1">
        <property type="nucleotide sequence ID" value="XM_007874629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PAA4"/>
    <dbReference type="STRING" id="1069680.M7PAA4"/>
    <dbReference type="GeneID" id="19894607"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00909"/>
    <dbReference type="eggNOG" id="KOG0331">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_16_9_1"/>
    <dbReference type="OMA" id="STMPKFE"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002151">
        <property type="term" value="F:G-quadruplex RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071042">
        <property type="term" value="P:nuclear polyadenylation-dependent mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17966">
        <property type="entry name" value="DEADc_DDX5_DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="153"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="356"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR10760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="536" mass="60198" checksum="3CA45C4D707F0755" modified="2013-05-29" version="1">MEYNSYDTFHKKARLNGFNSVNHGIGSKNTDNFDSSSLDKGKGAVCNNIYGKQEEYMSSNKSSKYDIKSVKRQWDSNCLPRFEKNFYKPHPNIEGMTDQEVEAFRKKGGITVQGINVPRPVPSFDEAGFPSYVINEVKRMGFSSPTPIQSQGWPMALSGRDVVGISATGSGKTLAFCLPAIVHINAQPLLSRGDGPIVLVLAPTRELAVQIQTECAKYGKSSRIRSACIYGGVPRGPQIRELASGIEICIATPGRLLDMLESGKTNLRRVTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKDVQKLAHDYLKDFLQVNVGSLDLNVNLDIKQIVEICSEYDKRGKLIKHLESAMEDNENRILIFVSTKRIADDITKYLRQDGWPALAIHGDKQQSERDWVLNEFRTGKSPIMVATDVASRGIDIKDVKYVINYDYPNSSEDYIHRIGRTGRAGAKGTAVTLFTIDNARQARDLLTVLRDSKQEIPPALIEMSKINYGNNKYIGNNRGRNVWTGSNNAPLNPIRKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAE5</accession>
    <name>M7PAE5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="12">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_00952</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="12"/>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872865.1">
        <property type="nucleotide sequence ID" value="XM_007874674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PAE5"/>
    <dbReference type="STRING" id="1069680.M7PAE5"/>
    <dbReference type="GeneID" id="19894650"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00952"/>
    <dbReference type="eggNOG" id="KOG0202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_3_3_1"/>
    <dbReference type="OMA" id="KMHACET"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140613">
        <property type="term" value="F:P-type manganese transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006413">
        <property type="entry name" value="P-type_ATPase_IIA_PMR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01522">
        <property type="entry name" value="ATPase-IIA2_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 12" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="10 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="829"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="891"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="926"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="13">
        <location>
            <begin position="67"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR10805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="964" mass="107485" checksum="20E12A3584B1EF7E" modified="2013-05-29" version="1">MISVFYNSFYFIFFSISILDFLQKKNLSIYYGLEIYQMSRKTPKKSLDKPRRLPYSVLPSKIQLKNDFWSIGIEECCAYLHTCHKTGLSSQEDIIYRKSVYGSNFLGPEKIGFPFFRFLKQLLGNFLMILLFVSALMSILVGNISDALSIIVAIIMVVSVGFIQEYRSEKSLKELNKMLPHYCHVIRNGQEQYVEAIELVPGDLIRLSTGDRIPADLRISEAIDLGIDESNLTGETNVVYKNADAISKSVYDIPITERKCIAFMGTFVRHGNGLGIVIGTGKDTEFGAAILDMQHIKSPETPMQKSMNHLGKQLSMFSFIIILIIYLVGLIQGRSWLEMSTISISLAVAAVPEGLPIIISITLALGVYRMSNKKVIVKNLPSVETLASVNVICCDKTGTLTENHMTVQKIFTLGRNGLIDLSSNFKKSLFMEDKTLNCLLNIANLCNNAQKISNKKFVGQSVDVAIMELIEKYGYPDNRMIYTRLQEIPFSSDRKWMSVTAYPSSMTPSSSVVYAKGSFEEICIKSASILEKDAVEIPLTKDVIDKVDKVASEMAHEGLKVIALASLFGSSINDKGFTIAGLIGLLDPLRKNVKKSIQHLIQNSIRIVMITGDSEAAALSTAYKLGIPIQYSKSYYINENSKDFVTIMSGSNLEKMTIKELSEVLPNISIFSRVTPRQKMKIIEALQIRGDVVAMVGDGVNDAPALKLADIGIAMGKQGTDVAREAADMILTDDSFSTILDAIDEGKGIYYNISNFIAFQLSTCIASLSLIAISIIFGFGNPLTATQILWINILMDGPPAQSLGCESINSNIIPNCPRKKDISLLTKPLLKKVIISSFLIVLGTILIYISQTRKNTERRSITMAFTCFVFFDLFNALTCRSNIKSIFNIGFFSNNIFNLAILGSFLGQISVIYLPFFQKVFYTEPLSFFELLFLIVVASTVFWIDEIRKFRTRKNIPKELIIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7PB09</accession>
    <name>M7PB09_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-demethoxyubiquinone hydroxylase, mitochondrial</fullName>
            <shortName evidence="8">DMQ hydroxylase</shortName>
            <ecNumber evidence="8">1.14.99.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ubiquinone biosynthesis monooxygenase COQ7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">COQ7</name>
        <name evidence="9" type="ORF">PNEG_00662</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + AH2 + O2 = a 3-demethylubiquinol + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:50908"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="1.14.99.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="8">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the COQ7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.60" evidence="8"/>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872562.1">
        <property type="nucleotide sequence ID" value="XM_007874371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PB09"/>
    <dbReference type="STRING" id="1069680.M7PB09"/>
    <dbReference type="GeneID" id="19894360"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00662"/>
    <dbReference type="eggNOG" id="KOG4061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071892_2_0_1"/>
    <dbReference type="OMA" id="NPLWYGG"/>
    <dbReference type="OrthoDB" id="275371at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008682">
        <property type="term" value="F:3-demethoxyubiquinol 3-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160224">
        <property type="term" value="F:3-demethoxyubiquinone 3-hydroxylase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01042">
        <property type="entry name" value="DMQH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01658">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011566">
        <property type="entry name" value="Ubq_synth_Coq7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237:SF4">
        <property type="entry name" value="5-DEMETHOXYUBIQUINONE HYDROXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237">
        <property type="entry name" value="COENZYME Q10 BIOSYNTHESIS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03232">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="237" mass="27393" checksum="8497CC3AED1C8BD4" modified="2013-05-29" version="1">MILRSLKENNKILNKRLKFSYNLIKFNRNVLYFCSNSSKFIKEETKKVYFPVRRLTKDENEIISKWVVLILDLGELGANYIYEGQYFVLSKTRPDVAPIIMDMWNQEKKHLETFNELLIKHKVRATELKYLCKTLGFALGVGSALLGTKSAMACTEAVETVIGEHYNDQLRETMCLKGYSSEIDDLREKIKKFRDEELEHLDIAVNSWDSKGSFAYGLITNIVKAGCIAAIWVCKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7PBW0</accession>
    <name>M7PBW0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="8 10">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_00387</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="8 10"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872261.1">
        <property type="nucleotide sequence ID" value="XM_007874070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PBW0"/>
    <dbReference type="STRING" id="1069680.M7PBW0"/>
    <dbReference type="GeneID" id="19894085"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00387"/>
    <dbReference type="eggNOG" id="KOG2015">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_13_1_1"/>
    <dbReference type="OMA" id="PYLENYM"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01488">
        <property type="entry name" value="Uba3_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000002">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.20:FF:000003">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014929">
        <property type="entry name" value="E2-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030468">
        <property type="entry name" value="Uba3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08825">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01181">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="E2 binding" evidence="11">
        <location>
            <begin position="351"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR11360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="434" mass="49449" checksum="86719F15EFF037B0" modified="2013-05-29" version="1">MPINKEIHKNESKLLNYGKSNRWLYISRILNRSGPFVDIKFIPGKQVHNFLNTCKVLVIGAGGLGCEILKNLALSGFKNITIIDMDTIELSNLNRQFLFKYSDIGKPKAICAAKYIMKRIKGVDITPFHCKIQDKDESFYMQFDIIISGLDSIEARRWINSTLVNLVDPKCPKSLKPFIDGGTEGLRGQVRVILPTISSCYECSLDMHIKNKTYPICTITNTPRLPEHCIEWALIIEWPKVFPDKTIDNDNSDHIKWIYETAKNRANQFNITGITPFFTESVVKNIIPTVASSNAIIAASCCNEAFKIATTCNPYINNYMMYTGTDSVYIYTFQLQKKPDCLICGYLAIVYEVDPKITLNEFIEKLIESPNTNVKRPSLRTGSKNLYLQTPPQLEKATRPNLNKSLEELIHNDEEILITDPNIPFNLNLKLKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7PC12</accession>
    <name>M7PC12_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase epsilon subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DNA polymerase II subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_03456</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875546.1">
        <property type="nucleotide sequence ID" value="XM_007877355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PC12"/>
    <dbReference type="STRING" id="1069680.M7PC12"/>
    <dbReference type="GeneID" id="19897143"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03456"/>
    <dbReference type="eggNOG" id="KOG0870">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043417_1_1_1"/>
    <dbReference type="OMA" id="MPRKETY"/>
    <dbReference type="OrthoDB" id="1707486at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22928">
        <property type="entry name" value="HFD_POLE3_DPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051377">
        <property type="entry name" value="DNA_Pol-Epsilon_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172:SF1">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="6">
        <location>
            <begin position="33"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="189" mass="21559" checksum="307ED879A90DB884" modified="2013-05-29" version="1">MTNEHDSSNELHLSPASISSKKKSVTVSIDDLNLPRSVVLRLAKKVLPEHTSIQKDAITALIRGSSVFINYLSAAAFDLSKLSSRKVILPSDVLKAMENIEFSSFIPRMTEELELYEEILKEKKNIIELHKNSSIFMESKDEHIIKKIKIDDNEILEKTIRSDVNKNNEYDNHTIDGEDYSKVEEIDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7PC60</accession>
    <name>M7PC60_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Phosphomevalonate kinase</fullName>
            <ecNumber evidence="3 13">2.7.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_03504</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP</text>
            <dbReference type="Rhea" id="RHEA:16341"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:16342"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.2" evidence="3 13"/>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875596.1">
        <property type="nucleotide sequence ID" value="XM_007877405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PC60"/>
    <dbReference type="STRING" id="1069680.M7PC60"/>
    <dbReference type="GeneID" id="19897191"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03504"/>
    <dbReference type="eggNOG" id="KOG4519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022059_1_0_1"/>
    <dbReference type="OMA" id="LVIHRTM"/>
    <dbReference type="OrthoDB" id="10262935at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016005">
        <property type="entry name" value="Erg8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035102">
        <property type="entry name" value="Phosphomevalonate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814:SF2">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017288">
        <property type="entry name" value="PMK_GHMP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="14">
        <location>
            <begin position="359"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR017288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR08064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="457" mass="51924" checksum="8030CDCCD511986F" modified="2013-05-29" version="1">MKRNKTVVSAPGKVLLAGGYLILEQENEGFVLTLSARMVCIVEDQEKKGEFPEIRVCCKQFKQPDYFFRVIFGENEEVSEIQEINRARNLHIYYALIYSLFYCNPSKMQDLYITILADNDYYSQNGPRSTLSKYKKFEFPIEMVHKTGIGSSSALMTSMIAALVVHLSDGKFDIQQTQNKWIIHNLSQIAHCSVQEKIGSGFDIAAACFGSCLYRRFDPAIIDSVGEYTSSQFKKQLTKVVESLWDISIEELDFPPGLGVVLIDRNKGTTTSNMARNVMAWKNKDTEANLIWEELKKANNLFYKTLSEMTNASHQFVSDYYEVLKISGQVSWDKDKIKFEDKTKQFIYDILYNLYSQLKLIREQLKIIGVKSNVPIEPPSQTLLLDKCIKIPGVLGVGIPGAGGYDAIFCIIIQQSNAKKDISSIELDDTDLSILLSKEEHAGLKVENNHEFDFFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCH2</accession>
    <name>M7PCH2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCDC174 alpha/beta GRSR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_03343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875422.1">
        <property type="nucleotide sequence ID" value="XM_007877231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCH2"/>
    <dbReference type="STRING" id="1069680.M7PCH2"/>
    <dbReference type="GeneID" id="19897030"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03343"/>
    <dbReference type="eggNOG" id="ENOG502S3J6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_990857_0_0_1"/>
    <dbReference type="OMA" id="QQAVHYD"/>
    <dbReference type="OrthoDB" id="333551at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180035">
        <property type="term" value="P:lncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071030">
        <property type="term" value="P:nuclear mRNA surveillance of spliceosomal pre-mRNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025066">
        <property type="entry name" value="CCDC174-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057464">
        <property type="entry name" value="CCDC174_GRSR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25449">
        <property type="entry name" value="CCDC174_GRSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13300">
        <property type="entry name" value="DUF4078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC174 alpha/beta GRSR" evidence="2">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="281" mass="33186" checksum="B55B3F0FA04B2C3F" modified="2013-05-29" version="1">MTLSGKNNETIAVSSASSIGLLAELSRVRDKFEREKSKKLDKSSNIYEKKKTLLTKSNVGVEYRAAKDRYEQENILEHEIKASRIALKRKAIQYQMMKRGAHDMNIKGVAAENLLVDFDRKWAEHQELETSSSSESEVDEENNPWVEYIDEFGRTRKVRKIDLPREITPEQEIPKNIIYGDFIQPFNPDEEQVRKILDEPEESAETFYDSTKEIRTKGVGFYQFSKDAQKREEERKALQEEHRLTELMKQNLEWAYDKRQKKLNERKKEIEKRRHKNIGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCW5</accession>
    <name>M7PCW5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vezatin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PNEG_00174</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the vezatin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872035.1">
        <property type="nucleotide sequence ID" value="XM_007873844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCW5"/>
    <dbReference type="STRING" id="1069680.M7PCW5"/>
    <dbReference type="GeneID" id="19893872"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00174"/>
    <dbReference type="eggNOG" id="ENOG502QSNT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005766_2_0_1"/>
    <dbReference type="OMA" id="RIEANSQ"/>
    <dbReference type="OrthoDB" id="21151at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017022">
        <property type="term" value="F:myosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026859">
        <property type="entry name" value="Myosin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026858">
        <property type="entry name" value="Vezatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15989">
        <property type="entry name" value="VEZATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15989:SF5">
        <property type="entry name" value="VEZATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12632">
        <property type="entry name" value="Vezatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin-binding" evidence="15">
        <location>
            <begin position="146"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMR11740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="622" mass="72768" checksum="0109764C864654E9" modified="2013-05-29" version="1">MMAETVIFKNTPLGDYLEDVKQGDDVESKIKTIFQSYYTSQARQLSRKRRCISSEVEYFSNKSYALLVKVYSLFSEFLSIYLSETEKSQFIERFRYIICTSQLLNENISPSLYHPQQSSINNKKKKSILFGIVTCDALYWSISGICIVVLALIINWNFKSNIHGIDKRVRYFFVFIISIVVALFLYTYHFRIYSKYIQKRAIFFMKRFVDTSQHFDITINKTLSLIQEVELISRGYLLSSPLPPITRIEANSQSRRCKMLRLLLSTLLSQAFLSYNRTFSLLQTFYSKREFDTLQIMYNLPNSQDFDFLPSYFKEDHSDGLPYLKALFYTIHEKRRQCLVSLLSMSTSSLKNISSWRCIIDQLKSLSDLMSNFDNEIEESLENNERISELSASKIKTNGKNVRWNDYTRNIGLLFQVLRRFQAKLYILKEETNCLIQGDFDENIRDEFLCYYDSLKDDLKVLMEKWESGRNCLLKICVESNTQTSKSLHSNLQKMEDSNPTFRKTLKLDSDNSIDESKNNKALSEITNDWEISSSYSQCPQSSEGMPSSTNEKEVVFETVSNNSELDIQLQKPTRAERIERIKKEREKHLKIKKDREIGMKVVSELKDVLGKRKIKSLNGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7PD10</accession>
    <name>M7PD10_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TIP41-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIP41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872060.1">
        <property type="nucleotide sequence ID" value="XM_007873869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PD10"/>
    <dbReference type="STRING" id="1069680.M7PD10"/>
    <dbReference type="GeneID" id="19893894"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00196"/>
    <dbReference type="eggNOG" id="KOG3224">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DMILFED"/>
    <dbReference type="OrthoDB" id="10253878at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007303">
        <property type="entry name" value="TIP41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF16">
        <property type="entry name" value="TIP41-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04176">
        <property type="entry name" value="TIP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="36237" checksum="9BA54D8FBC0AAA49" modified="2013-05-29" version="1">MIEKEDIVIQHLLPVPHTIVTSGTARSIHLQDWSVVSTKDSILTSQEIHQYSFRLSIPIPEMTFGKNSVEIKHSSGWKMIFTAYDALEGVDKTGKEVIQVSYAKEWVKNRDKSCESIEPSKSYDWTFTTAYRGTICYENGNDIADNEIMLIRAVKNKTLATKAEKDQDKNIDDVDKVVVPVFVLSDEVIPLDKLKRQDPILFFEEVVLYEDELSDNGMSLLSIKVRVMPERLLLLQRFFMRLDNVMFRIRDTRVYIEFSTGKVLREYIEKEAPYHEVLEKISSQQNDFGIFLTDPAWVASVLPTCEKTLEALKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7PD15</accession>
    <name>M7PD15_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleolar complex-associated protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00198</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872065.1">
        <property type="nucleotide sequence ID" value="XM_007873874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PD15"/>
    <dbReference type="STRING" id="1069680.M7PD15"/>
    <dbReference type="GeneID" id="19893896"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00198"/>
    <dbReference type="eggNOG" id="KOG2153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012441_5_0_1"/>
    <dbReference type="OMA" id="HYCPQVR"/>
    <dbReference type="OrthoDB" id="10263597at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011501">
        <property type="entry name" value="Noc3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016903">
        <property type="entry name" value="Nucleolar_cplx-assoc_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428:SF5">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07540">
        <property type="entry name" value="NOC3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar complex-associated protein 3 N-terminal" evidence="7">
        <location>
            <begin position="138"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="CCAAT-binding factor" evidence="6">
        <location>
            <begin position="473"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="365"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR11770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="659" mass="76912" checksum="3A37FD222743281B" modified="2013-05-29" version="1">MNEKMNGKIDLISKDKISKKAGILTSNLPLKKFNKKMKKKEIERKKRKKDNTYIYYERDHQGDELPYEKMGRSFNLVEDLSNTFTLPIKTRDGQVRLKREKNTGKKVSIEPEIIKAKNETKDIEIKDKKEKDIKEKDIKEKLASIAQIIIENPEENIGQLKILYNMTICNTISIQRLGLLTQLAVYRDIIPGYSIRPLTEIEKASSVSKEIKKRRLFEELLVSNYHEYVSLLSRTIKAGYKFPKKSPQQFLSDISFSCICYLLLSAPHFNYRDMLLDIISTKLTHKKTDVSFNECKKTIEELFKNDKEGEISLEIVKKLTNAMKKKNYNINDKVLNIFLKLEFLSQSNIPSEKKINNPRKRKHEKQFMSKKMRKLEKEKKEIENEMDSIKRNNQEKAKIQGKILKLIFTTYFQILRNGLINHIYASLEGLEKFSHLINVDFFEDLLKLLKELLENTFSVNLNISIKNNTKGGLLCIVVAFKLLSQQAQMKETINLDLSAFIFYLYSIMIPMSLNSYIEADIVYKSKKQDDNISNNDNSFTKLSEIEILEECFDYIFFQDKNLNLLRAAAFIKRLFTVLLGFPEKSVIKSLNLIQKLIKKHPKLNYFLSSNEKHGEGIYNGEIDNPDLSNPYLSTCWELILLKKHYSPTISNIVDTLFHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7PDB5</accession>
    <name>M7PDB5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_03279</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875352.1">
        <property type="nucleotide sequence ID" value="XM_007877161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PDB5"/>
    <dbReference type="STRING" id="1069680.M7PDB5"/>
    <dbReference type="GeneID" id="19896966"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03279"/>
    <dbReference type="eggNOG" id="KOG1167">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_118_2_1"/>
    <dbReference type="OMA" id="QGFTMEK"/>
    <dbReference type="OrthoDB" id="10020333at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031431">
        <property type="term" value="C:Dbf4-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001100">
        <property type="term" value="P:negative regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045739">
        <property type="term" value="P:positive regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903468">
        <property type="term" value="P:positive regulation of DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060903">
        <property type="term" value="P:positive regulation of meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905263">
        <property type="term" value="P:positive regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905342">
        <property type="term" value="P:positive regulation of protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904968">
        <property type="term" value="P:positive regulation of spindle attachment to meiosis I kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031503">
        <property type="term" value="P:protein-containing complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14019">
        <property type="entry name" value="STKc_Cdc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF23">
        <property type="entry name" value="CDC7 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="102"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="487" mass="57889" checksum="46AE9476E44B0522" modified="2013-05-29" version="1">MEIKNNKETKKTLTKEDKWQSDIYENSLFLENLNNSQKEDIDDDVTEIQSLEDRTSDYQSPKSSYNSKEEDNCYEELEKISENVRNEIKNLYETFHHLRKHYRLINKIGEGTFSSVYMAEDCNYDKYINEWQYKEQKTFSWNTPLLKRRKMLSKYDSYKKRYVALKKIYVTSSPARIINELKILKDLKGNDSIVPIITAMRVRDQIIIVLPYFKHIDFRDYYRTLSLEDIRFYFKKLFQALYHVHKNGIIHRDIKPSNFLYDVKRRTGVLVDFGLAERENYDETSCLCSNKNKSERFRNKKMLLSTAILNEIEEQPGYLKNDPRPSKRANRAGTRGFRAPEVLFKCMAQSTKIDIWAAGVILLSFLTRRFPFFNSSDDVDALTEITCIFGKNEMRKCAELHNCLFDTNISTLNEKRITFQKLIRWSTNFSTNYNIPLTWQEELAIDFLEQCLQLNPSERFSAEKALQHDFLKFIDEDEFTEEVNFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7PDL3</accession>
    <name>M7PDL3_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_03035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875086.1">
        <property type="nucleotide sequence ID" value="XM_007876895.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PDL3"/>
    <dbReference type="STRING" id="1069680.M7PDL3"/>
    <dbReference type="GeneID" id="19896722"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03035"/>
    <dbReference type="eggNOG" id="KOG0901">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095071_3_0_1"/>
    <dbReference type="OMA" id="IRQSKPW"/>
    <dbReference type="OrthoDB" id="407959at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="140" mass="15069" checksum="B992359DF2BA14C7" modified="2013-05-29" version="1">MSSKRARGTSGNKLRMTLGLPVGAIINCADNSGAKNLYIISVKGTGARLNRLPASSIGDMVLATVKKGKPELRKKALQVIIVRQRKPWRRRDGTHLYFEDNAGVIVNPKGEMKGSAITGPVGKECADLWPRIASNSGMVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>M7PDT9</accession>
    <name>M7PDT9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_03110</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family. PP-Z subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875166.1">
        <property type="nucleotide sequence ID" value="XM_007876975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PDT9"/>
    <dbReference type="STRING" id="1069680.M7PDT9"/>
    <dbReference type="GeneID" id="19896797"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03110"/>
    <dbReference type="eggNOG" id="KOG0374">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_3_0_1"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF484">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PP-Z1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="323"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="508"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="508"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR08634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="533" mass="60439" checksum="ECF4E8450B95FC21" modified="2013-05-29" version="1">MGQIQSRKEEEKIDTIGFSSRFDSKGVEGLCKGGQGINRVQKSLSLRSYEGGKKDKMKNTEGIVEAVEKTMENLKLKETSLDEQIFEKGSEHELSERAATIGASATDALPFKNHAHTRGSIPFSFFENIKTKKNNGQDKENQVNHQLLETSITQPSLSILQPKDTILIKRERDSISDTITPVNSLNLNMETSSTFMFFPSSYLSFKNLDVDDMIQRLLDAGYSGKVTKAICLKNAEVFAICQAAREIFLSQPSLLELTPPVKIVGDVHGQYADLIRLFEMSGFPPSANYLFLGDYVDRGKQSLETILLLLCYKIKYPDNFFLLRGNHECANVTRVYGFYDECKRRCNIKIWKTFIDVFNTLPIASIVASKIFCVHGGLSPSLSYMDEIRQLERPTDVPDYGLLNDLLWSDPTETTSGWEDNERGVSYCFGKNVIQQFLQKHDFDLICRAHMVVEDGYEFFNERTLVTIFSAPNYCGEFDNFGAVMSVSEELLCSFELLKPLDSHQLKRKMKKSRRNGSHIHLSPPAHQYPQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7PE19</accession>
    <name>M7PE19_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02892</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874929.1">
        <property type="nucleotide sequence ID" value="XM_007876738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PE19"/>
    <dbReference type="STRING" id="1069680.M7PE19"/>
    <dbReference type="GeneID" id="19896579"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02892"/>
    <dbReference type="eggNOG" id="KOG1725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028431_2_1_1"/>
    <dbReference type="OMA" id="DTQYWVV"/>
    <dbReference type="OrthoDB" id="10009287at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="198" mass="23042" checksum="5F75DE24406E20BA" modified="2013-05-29" version="1">MSFQDKLQAHVSRLDKELSQYSCLNQFERQWGIKKVYAVGGIIGIYFFLIFVNVGGRFLSNVLGCLIPMYYSVLAIESSNKANNTQCLSYWVIYGFLILIEHYEQSLLYWFPFYYFFKSIFILYLSLPQFNGAQTIYWTFFHPFFIKYCSKTTLVPTQDVSKVKDVSKVKDVSEVKDVSEVKEDIAAISESDLHSHSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7PEM6</accession>
    <name>M7PEM6_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02701</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CYC8/SSN6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874725.1">
        <property type="nucleotide sequence ID" value="XM_007876534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PEM6"/>
    <dbReference type="STRING" id="1069680.M7PEM6"/>
    <dbReference type="GeneID" id="19896392"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02701"/>
    <dbReference type="eggNOG" id="KOG1124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006762_2_1_1"/>
    <dbReference type="OrthoDB" id="418911at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000403">
        <property type="entry name" value="General transcriptional repressor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000078">
        <property type="entry name" value="Transcriptional corepressor Cyc8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051630">
        <property type="entry name" value="Corepressor-Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017:SF1">
        <property type="entry name" value="LD02225P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4 9" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="92"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="129"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="166"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="238"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="272"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="445"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="514"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="590"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="686"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="551"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="590"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="612"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="704"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR08919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="734" mass="84236" checksum="A69DD55662668FA2" modified="2013-05-29" version="1">MNEYERALTSYECVLRHNPYSVAAMTQIASILHANEQYQRAAEYFQSILNIDQSNGEIWGSLGHCYLMMDDLQKTYTAYQQALYHLQNPKDPKLWYGIGIFYDRYGSLEHAEEAFSHTIQIDPFFEKANEIYFRLGIIYRQQHKYPQSLECFRYILQNPPKSLTKTDIWFQIGQVYEQQKEYKLAKDVYEHILSENPDHAKVLQQLGWLCHQPNTSFTNQDHAVQYLTKSLEIDSHDVQSWYFLGRCYMAQQKYNKAYEAYQQAVYRDGRNPTFWCSIGVLYYQINQYRDALDAYSRAIRLNPYISEVWYDLGTLYESCNNQIGDALNAYQRAAELDPGNPHIKSRLQYLRNGKATGSHHTTTLPHPQDINPSNCQNSNLPAEISAQWSKSPHSSALVSSTVNDDIGKLPLLRPRSNEVDSPLPAQTSDISKKSFIHVTSNERHGQHTLSPTSYHHHIPSNPYDHERSNHSNHPHHTSIYPLQPSLESHNGSHPVYHLACPGNVTEESSLTPIHSNTFNTNHDMKHLNNQPNSHSSHTNHSKSSKQSVESIIHHDAKETWETTKRQKKWDEKSEIYEQKKTSSLKFGTKEMSYEKTSEKKESYTHNSFSRKVSKESLKVKELESKESPKSSKYGSSGTQKNLSSTFSSISSASKSLESLESDNSSQLINNSTKSNSDLVKSNNITEISNDGNIDTDGIKDSISKNELSSSENTQKIELTVRKININENYDNDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7PGS0</accession>
    <name>M7PGS0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[RNA-polymerase]-subunit kinase</fullName>
            <ecNumber evidence="2">2.7.11.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_02236</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.23" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874221.1">
        <property type="nucleotide sequence ID" value="XM_007876030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PGS0"/>
    <dbReference type="STRING" id="1069680.M7PGS0"/>
    <dbReference type="GeneID" id="19895929"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02236"/>
    <dbReference type="eggNOG" id="KOG0659">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="OMA" id="GIHHCHR"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140836">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat S5 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905866">
        <property type="term" value="P:positive regulation of Atg1/ULK1 kinase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07841">
        <property type="entry name" value="STKc_CDK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000097">
        <property type="entry name" value="Putative cyclin-dependent kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037770">
        <property type="entry name" value="CDK7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF0">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="10"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="16"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR09654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="340" mass="39195" checksum="115D00809A38389F" modified="2013-05-29" version="1">MDTDNKTKLYIKDRKVGEGTYAIVYLGRQLCTNRKVAIKKIKIGQLKEGLDISAIREVKFLREIKHENIIELIDVFLSKRNLNLILEFLTSDLELIIKDKSLIFSSSDIKSWLLMTLRGLHYLHSYFILHRDLKPNNLLIDANGVLKIADFGLARDYGNPYVNMTSQVVTRWYRSPELLFGAKSYGTSVDIWSIGCIFAELMLRTPYLPGNTDVDQLDTIFRALGTPTDEDWPGMRQLPDFVEFKQYPKPVNHRVLFTAASDDELRLLEWLLLFDPLKRPSAKQALKSKYFSSYPRPTPPSQLPKRNIEENEASSINLIWDDNISGTKFDTKSIARKLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M7PGY1</accession>
    <name>M7PGY1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873875.1">
        <property type="nucleotide sequence ID" value="XM_007875684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PGY1"/>
    <dbReference type="STRING" id="1069680.M7PGY1"/>
    <dbReference type="GeneID" id="19895594"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01900"/>
    <dbReference type="eggNOG" id="KOG1737">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007105_4_0_1"/>
    <dbReference type="OMA" id="SYFVRWV"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035621">
        <property type="term" value="P:ER to Golgi ceramide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000742">
        <property type="term" value="P:karyogamy involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000001">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041680">
        <property type="entry name" value="PH_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF203">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15409">
        <property type="entry name" value="PH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="169"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="815"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="890" mass="101376" checksum="9E5D46E61835B9DB" modified="2013-05-29" version="1">MTELETIEVQARDLLLRWIYIPDNETLSWQLKPHKKSIRYGICKRTKELNVSMRGETELCLLGASSYTSHCRLSKHRKCCKNRTLKERLEKAGLTEVVSFMRCKANVLEKGTYHVGPNNGGHFALVFDNTFSKQTSKIITYVLNACLMPLQVLSFQNTSLQSIVEVDPSTIYSGVLLKKKRSRLQGWARRYFTLNIATAVLSYTGSSSQSILRGIIPLSIAAVSVNPKLRCINIDSGAEIWHLRVLSDKDWIGWCRAIEKAAKNCNSKHIEQQSILDTDTILSSSQHESLNRQLWSKVENLVNKIGILKVEIDKMMQQRNDDTMGFFDTKVQHDSSNINDINQNSTSLVSLKRKKIILPSSIDGLSFDMKLSPFQIELISSELGNISNQFKSLLSEHNVLSQHASYISALKTPEISIDFISSRTSMDTTFTGESWFDAEEIPDNIKPYLLINSDSEGAITDELTADEDDNKMSNISQVSSIRRLSHNKNIERNKSKRVLYPLTYSVQVNRRDNIPPITVSPPSLFSFLRKNVGKDLSSITMPVIANEPLNLLQRAAEDLEYSELIDQAINKPKKDGERILYIAAFAISSFSNMRCKERLIRKPFSPLLGETFELVREDKGFRFLAEKVSHRPVVIACHAESTSWTFSHSPKPKQRFWGKSAELITDGSVLIKLITGDIYIYRKPAVFLRNVAFGEKYVEPSGHMTILNISTGEKAVISFKPGKMFSGRSEELFVQAYSGSGTLQPLSITGFWTHSLVLKRTGTNFKEVIWNVGSLVEDPSSHCGFTKFAASLNEITSMEEGLIPNTDTRLRKDQRNREDGNIEEAEKIKSHLEEKQRQRRKKMESENIEWKPRWFDQAKNQDPCWIIKTGNDSYWIQREKQTWTKIPELW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7PHV6</accession>
    <name>M7PHV6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THO complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01798</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873766.1">
        <property type="nucleotide sequence ID" value="XM_007875575.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7PHV6"/>
    <dbReference type="GeneID" id="19895492"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01798"/>
    <dbReference type="eggNOG" id="KOG1874">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000511_5_1_1"/>
    <dbReference type="OrthoDB" id="29024at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040007">
        <property type="entry name" value="Tho2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021418">
        <property type="entry name" value="THO_THOC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021726">
        <property type="entry name" value="THO_THOC2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032302">
        <property type="entry name" value="THOC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597">
        <property type="entry name" value="THO2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11262">
        <property type="entry name" value="Tho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11732">
        <property type="entry name" value="Thoc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16134">
        <property type="entry name" value="THOC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THO complex subunit 2 N-terminal" evidence="8">
        <location>
            <begin position="42"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 N-terminal" evidence="7">
        <location>
            <begin position="677"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 C-terminal" evidence="6">
        <location>
            <begin position="1046"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1788"/>
            <end position="1809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1789"/>
            <end position="1804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1974" mass="229414" checksum="2BD114C0244D725F" modified="2013-05-29" version="1">MENKNIDDKFIEKKSNFRETDSVKDYILNCVKIAEVAIANNCLQELEHIIFDIFDSFIVKHNISEKIVSTILLDIKKLNISFNMEDICLDNIWLFQNDGHCSEISPDNILSSLTVLLKELLAVGLVSMEIARERLESNLLVLVSAILSHVNFTKKVIRINTSLLYKQTKFNLIREENEGYSKLIVEINSFLESDILNKDKDMISLGIKQIFNNITSLIGFFDLDSNKVLDILLTIASQNLIYHWKIFIELFSISSWWGFAESYYNLKDITSLEKRKKLDNILQKGIQTFFDDIHCHSGSKVASQLLGFKLKNYNSENIQENPESLFMLIALLVKYELVDIGDILPYLSSNDNMIWTEWKNFNSNLEEKAYRARGNALSMAGALTDDSISKDKGDKENSSKIESSEPYFSTSQNFYNQKVLFLKALLSVGALPQAVYMFSEFPFLSGPYPELADLLHKIVHHMISDIYNKISPLSGLSKNLRQSLFQEKKRPLDMRFRDSLVFTHFPRVKLTLDPLPVHITNDLLKKFFYEDDAMNLIPVCETYDDFHKIVIPLLRFSSLRIYRDIKLLCKICRIGRAQIKEECSSQKVKEAWKNVLRGFLLPALSMIQVNPGVVNEIYDLIRFYSYSERYAFYGEWNNVIYKIYPELKVKVVEVEKETKGILRRISKTNVRQFGRVLAKVSHSNPCIVFSVALNQIESYDNLVDVVVDAARYITIFGYDVLTFILLISLSNENKKRLKDDGTSIAHWLQGLASFCGRLFKRYSNMDPITVIFYIVNQLKISNTFDLIVLKELIAQMGGILPPTNLSESQLQSLAGGEYLKQIAMSLIYDSKIISSKSSSRLLRALVESNLAGPLLILIAQQRLVCIYRLKDSNAPLKLLANLLDECQNVLVQYVEFLTTNLDFSNFSKLVPTIPDMCLKYGIEPVVAFYIARTKINEEIKRYYANEDFKKNKERLIEEKENYEKKNYANIENSINPPPNQIVTNNDTNISNISEDLEEGEEIEDNTKILLQSRHNENLNISNKSLSNSVLVSLAESITEILPKTTWCYISPWFYVTFWQLQLYDIYVPINQYEIEMNKMKTVIHNIDQDRSDVNGSLKKKKEKDLIVQKIEKCQAELSFQMSSYENTRKRIFLEKDTWFPFASVSIESNGPGSLGSHRRIEVSNHLIQYCFLPRCLFSPNDSIYCAKFIRLIHSFGTPNFSTLTLYDRLFGDYLPSLLFICTQQEAENFGRFLEEILTDLSIWYKDEIVYNKEAKGIKNLPGFQKRWSFSFRDKPQEHINDEDMLQYEEFKRLMYKWHRKLNQVFKICLDSQEYMHIRNAIIVLEKISQCFPVVAWMGRALKDKVSFIIEQEKREDLKVRALGYRAKLIKGESKWMSINQFQKIDNFSGQNNLFNDSWTQVSTSSTSLTTPSENNYLINSDSFAKYNQNSKKSVDNNFKDFDSKNSVLSDKSSDKSKQYNRLYEDQDLIMNVKSNNEIKGDSVINASVNKLRIESIIDSGYINNGSLKKDDFDTKISNISQFNRDEQIKKNISIDKTENVEVHQIDDKMLLNYNVSAQSKTLNSNLKIHEILNNDDSNFDSEDLSVKNSFETKKIKAIEPIEWLHSDDKISEYKDIRNNVTPDFQKHSILEKDLSSITETSLKKIEKTDIEEKLSLSSENLIQRIIANDAESTNLSMTKTEHATRTYRKVPTESTDSVIYQNKIKASQDKIDSLTVHSRRRQVMITNELKEQSQSNNSLLFSKFKDIPKGPSLSRDKFSDSKTFSSREILHDETSDPFNRKISPIKTSEMGKSRDVSEQRKSYDYEPSSMRRSRMRFDMEKPFIKRNVDESFRTYSSGLESDSRRESFLKESLKETNLKSNREDRRIVTLINKDVYNREKDYVHEVGNSGYNREKIRDNDNFNERNRFFTNKDVNFMERNIGKTRSLRESKDNFEYREHTRESAMFRKHSRVSSIRQIGNRELNDTFKRRRTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7PI22</accession>
    <name>M7PI22_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">U3 small nucleolar RNA-associated protein 25</fullName>
            <shortName evidence="9">U3 snoRNA-associated protein 25</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_01393</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
            <location evidence="2 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the UTP25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873328.1">
        <property type="nucleotide sequence ID" value="XM_007875137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PI22"/>
    <dbReference type="STRING" id="1069680.M7PI22"/>
    <dbReference type="GeneID" id="19895090"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01393"/>
    <dbReference type="eggNOG" id="KOG2340">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018705_0_1_1"/>
    <dbReference type="OMA" id="QDRGDTF"/>
    <dbReference type="OrthoDB" id="10264378at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010678">
        <property type="entry name" value="UTP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053939">
        <property type="entry name" value="UTP25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053940">
        <property type="entry name" value="UTP25_NTPase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933">
        <property type="entry name" value="ORF PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06862">
        <property type="entry name" value="Utp25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22916">
        <property type="entry name" value="UTP25_NTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 9" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP25 NTP hydrolase-like" evidence="11">
        <location>
            <begin position="207"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="UTP25 C-terminal" evidence="10">
        <location>
            <begin position="472"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR10114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="657" mass="77646" checksum="05735234CAF03901" modified="2013-05-29" version="1">MKTNKKIKIVNISKHTCINKKSQNLEHIKTKKKIKAKDDSTIFQTVKITELQKPKKQKQKSAEKTENLKIYENIKESNKNVELNNEITSCSDSENYNFNNKENNIDPFYHHYQFPDEIKLKSFIEKANENKWITKKTKIAEFEELIQYKLSETSNFGIELKIINSNISNLKLKKKLKESFFKHQAIYHTLNSLTNIQHILAAPIFSYQDFLFTYLNYNNKKEIRALYILHVLNHIYKTRHYVLKNNEKIQRFQNSQIEYRDQGFTRPKILILLSTKNSCLEVVQTIIDISGTEQQENKKRFINEYSIDIDNINMSKPADYKNLFIGNTDDMFRIGIKITRKTLKIFSDFYNSDIILASPLGLRLLIDEKGKKKNRDYLSSIEITIVDNANALQMQNWEHVSYIFDNLNLLPNEIHECDFSRVRNWYLDENSRFLRQTLIFSEYMTPEINSLFMNSLFNISGKNKIKQTYKGSIEDVKYKIQQIFLRLHPSDPCADPDIKFLYFKTSILPNIIRSKENGFIIFISSYFDFVRIRNYLSKEETSFTFISEYSSNSDVSKARSYFNTKNKKILLYTERAHYYRRYNIKGANTIIFYSLPENPLFYPELIGFINDTNENGNCNKQSKALFSKWDALKLERIVGSKRVSLMCHGTNDIFEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M7PIA1</accession>
    <name>M7PIA1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873401.1">
        <property type="nucleotide sequence ID" value="XM_007875210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PIA1"/>
    <dbReference type="GeneID" id="19895158"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01462"/>
    <dbReference type="HOGENOM" id="CLU_1714080_0_0_1"/>
    <dbReference type="OrthoDB" id="5340119at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="153" mass="18360" checksum="E08D3818FEA7F710" modified="2013-05-29" version="1">MEKRKQKNDILVLQKDIEFNETFLEKDENGNFINGDKASDFIKKLTKHNVSITSLDFMFIWAYVEEESFLHEIASILEVKKPYTLREWFANDKKFLSLDIRNYKFVNDIKRCVGWDDVSGCSIKNWTKYWLPSYIKNQKTSEETRKNKKKKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M7PIL7</accession>
    <name>M7PIL7_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873489.1">
        <property type="nucleotide sequence ID" value="XM_007875298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PIL7"/>
    <dbReference type="GeneID" id="19895237"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01542"/>
    <dbReference type="HOGENOM" id="CLU_491852_0_0_1"/>
    <dbReference type="OrthoDB" id="5405345at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="554" mass="65274" checksum="29AD857C1B35F6B5" modified="2013-05-29" version="1">MSMNKWKSSVFLIIKAQRMTLKHSLLSIFSGLCLFIPFTIIFCRKFKFLSYLYFLIKIWKNILEKDSDSSENDLKGGSNIDDCLKVNILANYLDIIQKTFKTESKFCTIEYKTKDQEKKILSRNRYFQYLRNNNFSPKYFFYFIEKGHLIQYPNIKKSNLYPFYRTNSLIHNIFRLSTFEKGELIPSIRFDSFLKLEIHNTFENLTSIDLFNKEIGKLKKIEDLFEDRKKNSENYSKIEVFSKNNQKRFIETSESNSTNQIASKISYKNTNPDISNSKGDVFEFQFISYLSEELIYISPIILKYNSIQDFDTVPDYKQKLYISLYSKKKNNYWPLSDIQNSSLKNTSTRLLCDSSPHVKKTSFKDKTSERNNILKENMSPNSKQNNIESLKKKNHKKITSDISNSHQDNPMHFIHLNYKIDEIILEKYNNKEVSKHKNNFSLKTEELSGSKINSIETNNTDSSLPETKHLTFNTIHINYSANYSNITPLSLNSLIPSPTSKYKNFKDRASSSIKINDIYKDSLRLLKEVYDDNRRRGIPPTPPPIRKRWEFVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7PIZ2</accession>
    <name>M7PIZ2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leo1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873049.1">
        <property type="nucleotide sequence ID" value="XM_007874858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PIZ2"/>
    <dbReference type="STRING" id="1069680.M7PIZ2"/>
    <dbReference type="GeneID" id="19894831"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01134"/>
    <dbReference type="eggNOG" id="KOG2428">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_604279_0_0_1"/>
    <dbReference type="OMA" id="TNIYRWS"/>
    <dbReference type="OrthoDB" id="20844at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007149">
        <property type="entry name" value="Leo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146">
        <property type="entry name" value="LEO1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146:SF0">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN LEO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04004">
        <property type="entry name" value="Leo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="53189" checksum="EB2DA77690D93FC9" modified="2013-05-29" version="1">MEGHSDEKIKVNESIIEETKKEAEKEEINEEKPLYFERLIADLEDFPEEELKEGLGNESDDLFGDDTSESEKEAKEGFEGKIKKIEETQEKLEDFEYQEARRVLESTLSNYAAPESTDGELYYIKMPNFLTVVEKPFDSNSYLEEACSEYEETTVNSYDNYQRIRLRIENTIRWRYVKNSDGTYSKESNARFLKWSDGSLSLLLGSELFSVVIKNSISDYMYLSISHETQSLLMSRKRFTKNMTFLPIDTRSSTHKRLTEAILRGNMKKSSIIEFINIEDPEKVKREAERIEEEKIRFRRRLESKRRARNARYNESPILTIEGLEAEETNDRFSGIYTKDDNYDDDDDGFIVDDESDEAERAERLRRVKEEGIKMYKRQQTSLTNENDQNEKKDTNVHWLLNEQDRNLDDTDYMKEIDLDDNIIGKAGKRRRIVDELSGDELTPVAKEIKNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJU7</accession>
    <name>M7PJU7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Biogenesis of lysosome-related organelles complex 1 subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872784.1">
        <property type="nucleotide sequence ID" value="XM_007874593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJU7"/>
    <dbReference type="GeneID" id="19894572"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00874"/>
    <dbReference type="HOGENOM" id="CLU_2074156_0_0_1"/>
    <dbReference type="OrthoDB" id="10337653at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="13890" checksum="6BF27E9F3AB4FD22" modified="2013-05-29" version="1">MKSEEFSKSCYTCVNTSNDLEKDHETFYSLYDLLDPLTRIMFSNIKDVYNTKNKLKEQLDCLIEKLKICLDLVNIQVLEGVYSDCIQLKERMNLIHKTFGEIESRIEKCCSILNQYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7PKD6</accession>
    <name>M7PKD6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_03605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873018.1">
        <property type="nucleotide sequence ID" value="XM_007874827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PKD6"/>
    <dbReference type="STRING" id="1069680.M7PKD6"/>
    <dbReference type="GeneID" id="19897292"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03605"/>
    <dbReference type="eggNOG" id="KOG0110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008479_0_0_1"/>
    <dbReference type="OMA" id="THFMGRR"/>
    <dbReference type="OrthoDB" id="439639at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12565">
        <property type="entry name" value="RRM1_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12317">
        <property type="entry name" value="RRM4_RBM19_RRM3_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12320">
        <property type="entry name" value="RRM6_RBM19_RRM5_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="2"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="275"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="457"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="571"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="669"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="762" mass="87228" checksum="90C6811A1AADAAF4" modified="2013-05-29" version="1">MSRIIVKNLPKYLNEDRFKDHFSACGKQITDIRLVRSKNGKFRGFGFIGYKTKEDALNSIKYYHNTFIDTSRISVEYAKEVDFVTLGLRNTFKNDKFSFKDCIHSENNKLAFDELMEQKRENKKPCISLEHVQIGSSGDFFGKNDDVFSKNKLDCLDDSIDVNNNSLYSHSVSDEKANNMHSYNNFLHCKEQTYGCSNLHNFKKSFDVSYVKTMTNDDWVKSKLKQIKELGDENCNDCNSDDELDNQNSFLHEKNVSGLNNDNVLSLKEQILLSGRLFVRNLPYSISESELRIVFENFGKLIDVHVPYDSVLNMTKGFAYILFENPSCALNAYELMDGRALYGRLIHILPARVKRASDRSESYNGTNFKNERAKRRKIDALDKRFSWNSLYMNPDAVISSVADKLGVSKTDILDPTSSNSSVRQALAETYVIQETKKYFEKSGVNLESFSGFELDDYVLLAKNFPYGTTLDELSKLFGKYGTLGRVLLPPSGTIAIVEFLESKSADNAFKCLSYRRFKDSILYLEKAPLNIFKEKFDSTIDLQTANSQKSKAIYDIDINIENDNVNDSERAILFIKNLNFSTTLDSLNNAFSPFDGFVNVVIKTKSDPKRPGNRLSMGFGFVEFKSRYHALLAMHVMKGYVLDGHVLQIKESQKNNNFSLKDKISQNKCKIVIKNLPFETTKKDIRELFGSYGYLKSVRVPKKIDNSIRGFAFVEYVTSRDAKNAFNILKNTHLLGRHLILEWADDSVVNDSDNRQKLVEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7PKW5</accession>
    <name>M7PKW5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein FYV10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00711</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FYV10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872611.1">
        <property type="nucleotide sequence ID" value="XM_007874420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PKW5"/>
    <dbReference type="STRING" id="1069680.M7PKW5"/>
    <dbReference type="GeneID" id="19894409"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00711"/>
    <dbReference type="eggNOG" id="KOG0396">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027445_2_0_1"/>
    <dbReference type="OMA" id="ANHETAR"/>
    <dbReference type="OrthoDB" id="1933455at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16659">
        <property type="entry name" value="RING-Ubox_Emp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN TRANSFERASE MAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CTLH" evidence="8">
        <location>
            <begin position="157"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="RING-Gid-type" evidence="9">
        <location>
            <begin position="318"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="7">
        <location>
            <begin position="318"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="47608" checksum="D08AC3012ABBD753" modified="2013-05-29" version="1">METTKVNLENHLMLEQSMIRLPYEILRMNFKISQKYVEKHSSFLLSEIEKLNFNTEDEMQASMEKLNNILYKTQELKEKLFMLNQKDVQCFERLKARIDHLRELHDIENIEDEGYESWNQIRLDRLLIDYMLRKGMSETAKQLAKEKNIENLVDIDVFVRCKKIEEALRNKDTTKCLAWCAENKAFLRKNKVNLEFELKLQEYVELIRKGERFQAIAYSRKYLTQFSEAHIDEFKRSMALLIFPPDTECEPYKRLYSPDRWELLADLFVLTHHNLYNLSIPPLLYITLSAGLSSLKTPSCYSSESKKANTTLFHSTLCPICSSELNSIASLVPYAHTARSSLIDSLTGEKIQSDNELIALPNGRVYNQRSLFEKNEKFGIPKDVIWDPATTEKFPREKIRKVFIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7PLF3</accession>
    <name>M7PLF3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Clathrin/coatomer adaptor adaptin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00294</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872166.1">
        <property type="nucleotide sequence ID" value="XM_007873975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PLF3"/>
    <dbReference type="STRING" id="1069680.M7PLF3"/>
    <dbReference type="GeneID" id="19893992"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00294"/>
    <dbReference type="eggNOG" id="KOG1060">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006320_3_2_1"/>
    <dbReference type="OMA" id="HFLVRST"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="10"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="725"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="728"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="743"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR11264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="775" mass="89759" checksum="1767D87E2BFA5E6D" modified="2013-05-29" version="1">MSQEINFRNQSISTEINRLLNSGSEKDKLYGLKKVIYSMSYGMDMSEYFMSVVKNISSSNFEIQKLVYMYIIRYSEYDPNLSLLSINTIQRKLNDKNQIFRGTAIRMLSGIRVPAISKIILSEIKRCIMDMSFYVRKAAAISMVKCYRLDSSSLPILIEYLLILFNDQSHIVFGSALFVFQELCPEKLDLIHPYYRKICKVLHKLSEWDQVTALNILLVYARKCFLKPDDKTSYNSEDLNKKESFFNEESYFNEESNEKAEESINNILNKDLNLLLTSIIPLLRSRNSSVIMAACKILYHVGPLTKQSELAKPLIYLLKESSDIQYIVLTNIIAIAIKHPTFFSPFYKHFFIYPSDSQSIWELKFEILSLIARKENIKDILEELKWHTKSSNPNIIFKAIKSIGYCAVNHCSISELCLQNLIGNINSANDTLIVESIFIISQLIQLNPKDNLHYIEQLVLYYDSIKVASAKACIIYLMSKNIFNLPKLSLDMLRILAKSFSQQEEIVKSQILIFAVKLYIIYSSNCFEEKLEDSPLDIFLKNSKISNISDENNIPSSLILEKNKMPENEVIYNNPSNKLIVTKLYDYIMLLARYDLSYDLRDRARLYKFLALNSTSLFTQKVVFSFSPNIKMTTDSIGRETFTLGTLSLMLFKQIKGYENLPNWSDDITQLPHPNLREEKHNNIFEDTNDNFLKTSTSKKDKKDNSILLNINSVEILDLDDFYRSNTDTEDEDSETEIESKFNSNYEENTNSESTKKETSFENEEADNKQIIPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7PLH0</accession>
    <name>M7PLH0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA-splicing endonuclease subunit Sen34</fullName>
            <ecNumber evidence="5">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00312</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="5"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872186.1">
        <property type="nucleotide sequence ID" value="XM_007873995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PLH0"/>
    <dbReference type="STRING" id="1069680.M7PLH0"/>
    <dbReference type="GeneID" id="19894010"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00312"/>
    <dbReference type="eggNOG" id="KOG4133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049366_0_0_1"/>
    <dbReference type="OMA" id="RTFSLEW"/>
    <dbReference type="OrthoDB" id="48041at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032473">
        <property type="term" value="C:cytoplasmic side of mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000008">
        <property type="entry name" value="tRNA-splicing endonuclease subunit Sen34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016690">
        <property type="entry name" value="TSEN34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059049">
        <property type="entry name" value="TSEN34_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00324">
        <property type="entry name" value="endA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26577">
        <property type="entry name" value="TSEN34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017250">
        <property type="entry name" value="tRNA_splic_SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TSEN34 N-terminal" evidence="9">
        <location>
            <begin position="14"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="8">
        <location>
            <begin position="183"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00059865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR017250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="275" mass="31675" checksum="AC8A388832F1FB38" modified="2013-05-29" version="1">MSNSIFEIKKDRVIIYFVASNYFIYDYKTVMQLRLKYHICGFFVGTLPQAPQQNVFLGLPLELIPEEVAWLVDQGHAYIVDDKLRHQLYIENVTLEDVLSIKEKRIADIKRQNVEYKRNLREKSAINLLKDTSSSNLDSIISSLDNYDAEDDIPRNIVVPTKSKKSLYAMSIELSPKVKVDLSRYSVWKYLHDKGYYMTPGLKFGAHYLAYPGDPLKYHSHFLVNVMEWEQEFSIINIVGGGRLGTNVKKAWVIGANNPNTNIAHIFTVEWTGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M7PLT9</accession>
    <name>M7PLT9_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872330.1">
        <property type="nucleotide sequence ID" value="XM_007874139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PLT9"/>
    <dbReference type="STRING" id="1069680.M7PLT9"/>
    <dbReference type="GeneID" id="19894148"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00450"/>
    <dbReference type="HOGENOM" id="CLU_1603692_0_0_1"/>
    <dbReference type="OMA" id="KFHDEHF"/>
    <dbReference type="OrthoDB" id="5335351at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024526">
        <property type="entry name" value="DUF3807"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12720">
        <property type="entry name" value="DUF3807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="173" mass="20542" checksum="9284527A07D02003" modified="2013-05-29" version="1">MINQNKFPEISEKDLISFHENHFNSESLGIFSSFLEKDEKNIFNNANSLGFHTYADGNIRTLNEEDIAYFKWSESFKSKAEHTTYFVSNKNKTESLENEEMKEELKAHVPSYSKLVRNDDELFLRYGEKYELIKKAEDALDTYYYELSRKNTNYETDENKIKVNYWPATPIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7PM56</accession>
    <name>M7PM56_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ferrochelatase</fullName>
            <ecNumber evidence="7">4.98.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00562</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>heme b + 2 H(+) = protoporphyrin IX + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.98.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ferrochelatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.98.1.1" evidence="7"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872455.1">
        <property type="nucleotide sequence ID" value="XM_007874264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PM56"/>
    <dbReference type="STRING" id="1069680.M7PM56"/>
    <dbReference type="GeneID" id="19894260"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00562"/>
    <dbReference type="eggNOG" id="KOG1321">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018884_1_0_1"/>
    <dbReference type="OMA" id="DPYHCEC"/>
    <dbReference type="OrthoDB" id="1323at2759"/>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1400:FF:000001">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0408">Iron</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR11554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="398" mass="45055" checksum="66AF30B2949F7203" modified="2013-05-29" version="1">MINSPKIIRNTLKNLPYNQRLFSNFLLSSMNLTTETKKSNGPTGIVFLNMGGPSELSEVKNFLFRIFTDSDLIPLGSMQKWLGSLIAKLRTPKVSNHYKKIGGKSPIYRWSKLQAEEVCKILDKTCPKTAPHKPYIAFRYSAPLTESVLLEMLNNNITNAVAFTLYPQYSCSTTGSSLNELYNQIQRLNIHDQINWSVVDRWPTHDGLINAFKNNIIETLKTYPENDRNNVIILFTAHSLPMSIVNRGDPYPLEVAATVYAVMEKLNFSNPYRLVWQSQVGPSTWLGPQTDHVITSFTRMGKQNIILVPISFVSDHIETLFELDLKYIANAKKSGFNGVKRVESLNNNLTFIKGMADILKNHLTNGRKSSTQLELPCSSCMSLKCHSTKSFFNNFNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZB32</accession>
    <name>A0A0W4ZB32_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major surface glycoprotein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_04014</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000020">
        <property type="protein sequence ID" value="KTW25438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873818.2">
        <property type="nucleotide sequence ID" value="XM_007875627.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZB32"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZB32"/>
    <dbReference type="GeneID" id="19895541"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04014"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021041">
        <property type="entry name" value="Maj_surf_glycoprot_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003330">
        <property type="entry name" value="MSG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46345:SF8">
        <property type="entry name" value="FORMIN 3, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46345">
        <property type="entry name" value="INVERTED FORMIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02349">
        <property type="entry name" value="MSG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12373">
        <property type="entry name" value="Msg2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Major surface glycoprotein 2 C-terminal" evidence="3">
        <location>
            <begin position="911"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="776"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="998"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1076"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="776"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="813"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="998"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1084"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KTW25438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1127" mass="126079" checksum="3A154BD048E77493" modified="2016-03-16" version="1" fragment="single">EVAQKEAAMAQPVKRQAAGQAAGNDEIKEEQVLGLIVKSGYNNDNKCKADLKQYCEELKKIDGKLESVDVKVKGLCENIDKKCGDLKDKVKTELDAFKTELEKELNNLTDEKCRKYEEKCLLLEEADPSNLEEKCVKLRDRCYRQRRQGVAKEILLRALEGKVNDTNECKKKMKEICQGLSEYSDELVFSCFNSDKTCEYLQKNHGDSCKPLEKELEDKELVEKCQEYLEKCYFYGSSCKDTKCDKVKNKCKGKGIEYEGPKLDFSPVREKPRFPEKIEVENLYKKEEAKGIIVGKPKYKTLRDLALLLIKERNGKDEGEKCKKALEDCESFKHLDYGLEELCGDKDKEDRCKELVEVEDRCTNFKLELYLKGLSTEFEKDKESDYFSWGQVSKLVSREDCIKFESECFHLEGVCTNKIGKACENVRVACYKKGQDRVLNRYFQEGLKGLIGDLELVTENLEKCQKSVVGNYTKLKEDRRYFTKCHLPTKLCYELLDDVILQSEELEVVLNLRRDFPRKEDCVELKKKCKDLESDSYLNHEKCDTLNRRCEYLKVTEELRKRLLKRGDDALRTQGNCTAVLKKECEELSRRGKEDFSVSCALQEETCSFMVEQTENECLFLKNNMENGKIIDKIEKGKGNETLVEELCTLFDPYCHQYIENCPDRLKKTNNAGRKGVCLELEEKCKPFFEKLKLENELTHELKGSLSDETECKKALGKHCTEQKDLANKKFNSFCNTDKNKDVEEKVCKKLVEKVKRKCPTLEDKLDKEKDELKKKKDEYEKVKQESEKFTKEAKLVLSKPEQDGQDGNAPKPGGPPVQPPVPGGTPGGVPVPAPTLAPPAPVPGGTPGSVPVPAPTLAPPAPGAPGAPGTPGAPAGPAGPAGPSGGTPAAPAGPPAPGGSTPSGTTNTSNVILVRRTFVSGEVSEPEKKAFVATARALELYLELKEKCKSLKGDCEFRKDCPKCEAVCTEIDKLCEGIEGLKVTPHHTVISTATQTTTTTATTTTTTTTTTTTTTTTTTTATTTESVDGGKVTEECTLVQTTDTWVTSTSLHTSTLTSTSTVTSTVTLTSMRKCKPTRCTSDSSKETETQKEEEKEEEVKPNEGMKIRVPEMIKIMLLGVIVMGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWY4</accession>
    <name>A0A0W4ZWY4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major surface glycoprotein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_04308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="KTW32877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613353.1">
        <property type="nucleotide sequence ID" value="XM_019757826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWY4"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZWY4"/>
    <dbReference type="GeneID" id="30671590"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04308"/>
    <dbReference type="OrthoDB" id="5477726at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003330">
        <property type="entry name" value="MSG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02349">
        <property type="entry name" value="MSG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KTW32877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="594" mass="68793" checksum="5A20244853075595" modified="2016-03-16" version="1" fragment="single">MAQPVKRQAAGQAAGNDEIKEEQVLGLIVKSDYSDDNKCKANLKQYCEELKKIDGKLESVDVKVKGLCENIDKKCGDLKDKVKTELDAFKTELEKELNNLTDEKCRKYEEKCLLLEEADPSNLEEKCVKLRDRCYGRRRQGVTKEILFRALEGKVNDTDECKKRMKEICQGLSEYSDELIFSCFNSDKTCNGLKGSHQDSCKSLETELKDNELMEKCQEYLEKCYFYGSSCKDTKCDKVKNKCKGKGIEYEGPKLDFSPVKEKPRFPEKIEVENLYKKEEAKGIIVGKPKYKTLRDLALLLIKERNGKDEGEKCKKALEDCESFKHLDYGLEELCGDKDKEDRCKELVEVEDRCTNFKLELYLKGLSTEFEKDKESDYFSWGQVSKLVSREDCIKFESECFHLEGVCTNKIGKACENVRVACYKKGQDRVLNRYFQEGLKGLIGDLELVTENLEKCQKSVVGNYTKLKEDRRYFTKCHLPTKLCYELLDDVILQSEELEVVLNLRRDFPRKEDCVELKKKCKDLESDSYLNHEKCDTLNRRCEYLKVTEELRKRLLKRGDDALRTQGNCTAVLKKECEELSRRGKEDFSVSCAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWY6</accession>
    <name>A0A0W4ZWY6_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_04311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="KTW32880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613355.1">
        <property type="nucleotide sequence ID" value="XM_019757828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWY6"/>
    <dbReference type="GeneID" id="30671591"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04311"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KTW32880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="74" mass="8668" checksum="9ECA77CA921C93CE" modified="2016-03-16" version="1">MCLGFIPTTFQNCKIYVNIESNHFEQCLNNICLGKALEEVFVSNLAHNILIIFKLIIKIFEKKNIYIFLVKRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWZ0</accession>
    <name>A0A0W4ZWZ0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_04011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="KTW32883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613357.1">
        <property type="nucleotide sequence ID" value="XM_019757770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWZ0"/>
    <dbReference type="GeneID" id="30671547"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04011"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KTW32883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="75" mass="8773" checksum="18B169EF4DB4FC7B" modified="2016-03-16" version="1" fragment="single">MYAYHKKIKMYGYFERIISRFRFDSPSHMLLRDKRWVEEVAQKEAAMAQPVKRQAAGQAAGNDEIKEEQVLGLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7NIF9</accession>
    <name>M7NIF9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_03198</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875261.1">
        <property type="nucleotide sequence ID" value="XM_007877070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NIF9"/>
    <dbReference type="STRING" id="1069680.M7NIF9"/>
    <dbReference type="GeneID" id="19896885"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03198"/>
    <dbReference type="eggNOG" id="KOG0219">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_10_2_1"/>
    <dbReference type="OMA" id="LVRFPQK"/>
    <dbReference type="OrthoDB" id="295033at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032302">
        <property type="term" value="C:MutSbeta complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000406">
        <property type="term" value="F:double-strand/single-strand DNA junction binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032137">
        <property type="term" value="F:guanine/thymine mispair binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000404">
        <property type="term" value="F:heteroduplex DNA loop binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032138">
        <property type="term" value="F:single base insertion or deletion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007534">
        <property type="term" value="P:gene conversion at mating-type locus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043570">
        <property type="term" value="P:maintenance of DNA repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006311">
        <property type="term" value="P:meiotic gene conversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000710">
        <property type="term" value="P:meiotic mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000735">
        <property type="term" value="P:removal of nonhomologous ends"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000017">
        <property type="entry name" value="DNA mismatch repair protein Msh2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001115">
        <property type="entry name" value="DNA mismatch repair protein MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF35">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="9">
        <location>
            <begin position="590"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="775" mass="89209" checksum="5A0DE52B2C2D035D" modified="2013-05-29" version="1">MTLLAVKVLVKENQRSIGIAFTDFLTKKIGISEFTDNELYNNYEFLLVQLNVKEVLMCFNERENFELSKIKGITENAGIKITEMNSKDFKINNIEHELDQILDENSLKMLSHIDDKICKDSMSAIIKYLLVTNDLIETEKFGIYKYNLSQYMKLDIPALKALSLFPCANSESNTCLYNLLNRCKTPIGSLLLTQWIKQPLVDQNEIEKRHTLVEAFCKNLETMRIIQDFLKSFPNIYKLSRKFEKKDATLEEVVRVYQTVVKIPNIINAFEKIEDDNYLSLIEESYLSKLRELYETFKKYIELVETTIDFEAMNNHEWVVKSEFDESLCRFSDELNELKNKIQEEYIRVSEDLEQDTLKKLKLEQSEIYGWCLRLTRSQSHCIKNKNYIELSVLKSGIYFTTSIMRRLSNEYNDIMTQYKNQQKQLIKEIVEIAASFCPVMEKLGLVISQLDVIISFSDISISSIIPYVRPIISKKNKIMLKDSRHPCLEIQSDITFISNDVNLERGVSEFLIITGPNMGGKSTYIRQIGLIVLMAQIGCFVPCAEAEISIFDSILARIGSNDSQLKGISTFMAEMLETATILQTASSNSLIIIDELGRGTSTTDGFGLAWAISEYIISKINAFSLFATHFHELTELSKKYSIVKNLNVIVHLENNNKNKDVTLLYKVKPGICDQSFGIHVAKMINFPESVVKLAKRKADELENSISIINDKKYNTGDIKTGTNILLQIMNDWKEKIKESDMSGLEMLSIFRNLVQEKYIFDIENNTWIQKIIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NIJ4</accession>
    <name>M7NIJ4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tetrapyrrole biosynthesis uroporphyrinogen III synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875306.1">
        <property type="nucleotide sequence ID" value="XM_007877115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NIJ4"/>
    <dbReference type="STRING" id="1069680.M7NIJ4"/>
    <dbReference type="GeneID" id="19896927"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03240"/>
    <dbReference type="eggNOG" id="KOG4132">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051874_0_1_1"/>
    <dbReference type="OMA" id="IHGADTG"/>
    <dbReference type="OrthoDB" id="5595751at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390">
        <property type="entry name" value="UROPORPHYRINOGEN III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390:SF0">
        <property type="entry name" value="UROPORPHYRINOGEN-III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="HemD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrapyrrole biosynthesis uroporphyrinogen III synthase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="255" mass="29849" checksum="EA81725BC8B7ECCD" modified="2013-05-29" version="1">MKTILFLRKRSTSEDNYESVFKEYNFYTIFIPVLTCSYINQEHLIHVLKNCPYTMYSGLIFTSRNAILAFRESLMSIDKQEHKKILCMTVYIVGPACYKEAISLGFFEVYGKESGNAENLSNFIISYHKDKNPILFLTGERRIDTLKEKLSSSSIILKELVIYKMNETIEFENDFNKAIYNKSLNVEWIVFFSPYGSDIVMKYMKNEDLSKFKIATIGFTTLRYLNDKWNIKTNVVSQCPEARSLLKGILDYERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJK1</accession>
    <name>M7NJK1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02943</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874988.1">
        <property type="nucleotide sequence ID" value="XM_007876797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJK1"/>
    <dbReference type="STRING" id="1069680.M7NJK1"/>
    <dbReference type="GeneID" id="19896630"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02943"/>
    <dbReference type="eggNOG" id="KOG4431">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2513599_0_0_1"/>
    <dbReference type="OMA" id="KSREEPF"/>
    <dbReference type="OrthoDB" id="6604018at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF3">
        <property type="entry name" value="HIG1 DOMAIN FAMILY MEMBER 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="7">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="85" mass="9743" checksum="95CE0142C22552D7" modified="2013-05-29" version="1">MSTASQNTEKNNWKKIIEKFKKEPLVPIGMVATCLALFSAAIAIQQNNKRLANRMFRYRVYAQGFTIISMIVGSIYYRHLNSSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJP5</accession>
    <name>M7NJP5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thiamine pyrophosphokinase</fullName>
            <ecNumber evidence="7">2.7.6.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02615</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>thiamine + ATP = thiamine diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11576"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18385"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the thiamine pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.2" evidence="7"/>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874634.1">
        <property type="nucleotide sequence ID" value="XM_007876443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJP5"/>
    <dbReference type="STRING" id="1069680.M7NJP5"/>
    <dbReference type="GeneID" id="19896306"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02615"/>
    <dbReference type="eggNOG" id="KOG3153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044237_0_2_1"/>
    <dbReference type="OMA" id="HHLYMMT"/>
    <dbReference type="OrthoDB" id="25149at2759"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.320:FF:000001">
        <property type="entry name" value="Thiamine pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.320">
        <property type="entry name" value="Thiamin pyrophosphokinase, thiamin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016966">
        <property type="entry name" value="Thiamin_pyrophosphokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031057">
        <property type="entry name" value="Thiamin_pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="Thiamin pyrophosphokinase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamin pyrophosphokinase thiamin-binding" evidence="8">
        <location>
            <begin position="171"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="249" mass="27901" checksum="1CFAD1065DC1F443" modified="2013-05-29" version="1">MNEYCWFPSEFLSGKATSIFKKYAIIILNQPLSLEYDKFLVLWKKASLKICADGGANQLHMLYKDNLDILPDFIIGDMDSLSSCALEAYSSKGVKIIKNFDKNSSDFGKSMDLINSINLSVTDVIALGTFSGRVDQSLESINQAYLASLLTPPINLYLFSVYNITFLLLQGINKIHLDLSILGPHCGLVPIGKKCIVTTEGMKWNMKNQVMEYGGLISTSNMVFENIIIVKTNEKVLFTIEIRSHDKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJR4</accession>
    <name>M7NJR4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tropomyosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874659.1">
        <property type="nucleotide sequence ID" value="XM_007876468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJR4"/>
    <dbReference type="STRING" id="1069680.M7NJR4"/>
    <dbReference type="GeneID" id="19896331"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02640"/>
    <dbReference type="eggNOG" id="KOG1003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104738_0_1_1"/>
    <dbReference type="OMA" id="EQWETKY"/>
    <dbReference type="OrthoDB" id="128924at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070648">
        <property type="term" value="C:formin-nucleated actin cable"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990819">
        <property type="term" value="C:mating projection actin fusion focus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003786">
        <property type="term" value="F:actin lateral binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902404">
        <property type="term" value="P:mitotic actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032220">
        <property type="term" value="P:plasma membrane fusion involved in cytogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="18889" checksum="522E1F863995AE0F" modified="2013-05-29" version="1">MEKLKEKISLLRMEAEEANGRADEAAARIKQLEYELALKEQECVSLMHKNELLEGEIERLEAQLLEVKTAVEDESGSRNISECLQKKIQILEEELELNDSNLRKTTDALRLMDVKTEHFERRVSVLEKERDEIEAKYEEMTRKYEHVKAELDEVNQQLESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7NK46</accession>
    <name>M7NK46_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02778</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874809.1">
        <property type="nucleotide sequence ID" value="XM_007876618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NK46"/>
    <dbReference type="STRING" id="1069680.M7NK46"/>
    <dbReference type="GeneID" id="19896467"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02778"/>
    <dbReference type="eggNOG" id="KOG2669">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042070_0_0_1"/>
    <dbReference type="OMA" id="HYELDIE"/>
    <dbReference type="OrthoDB" id="10069473at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099122">
        <property type="term" value="F:RNA polymerase II C-terminal domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17003">
        <property type="entry name" value="CID_Rtt103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047883">
        <property type="entry name" value="Rtt103-like_CID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460:SF0">
        <property type="entry name" value="CID DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="3">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="225"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR09003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="335" mass="37718" checksum="99C76A17F86206E2" modified="2013-05-29" version="1">MATPDLIRSKFAALNSGSQEEITSVSSWVLFHRRSAKQIVETWMQSLRDASGLRKLNLIYLANDVTQQSKARKREEFVNAFSTVIAEAMENAYRHGTQDVQNRLKHVANVWEQRNVFSENVIMDVNKRLEIAEKSVKKSLSGGKMGGLLKLSLAPELSKINLLYHSLIESISSSSLAIGSSFGFYSQLIEAEATPASPLYVSKLFQLLESLKLSYSTSKAAILVREDIIKQLEALLQENNSMLSKENEQLNEIQKKIDHVNDMKQQVEKMITDMLETSEDENPSSSTAIKEEFSSKDQQTLLYEESSELPVINDGTKIDSEVLDLKKVSNNLTYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NKL7</accession>
    <name>M7NKL7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_02527</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874537.1">
        <property type="nucleotide sequence ID" value="XM_007876346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NKL7"/>
    <dbReference type="STRING" id="1069680.M7NKL7"/>
    <dbReference type="GeneID" id="19896219"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02527"/>
    <dbReference type="eggNOG" id="ENOG502QQIZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050414_0_0_1"/>
    <dbReference type="OMA" id="WEPESTF"/>
    <dbReference type="OrthoDB" id="166907at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19496">
        <property type="entry name" value="Elp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019519">
        <property type="entry name" value="Elp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10483">
        <property type="entry name" value="Elong_Iki1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR09188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="263" mass="30145" checksum="4B8957A88C0F3F30" modified="2013-05-29" version="1">MHHAASDYSIPLFYKDNKNLMKKELSTLIYNIKEITSKYEISQRFIILVDSIDAFNLTNKINLSDIISSILSLNVSKTLILIYHSSIPLLKSYPVYYPLPSEFLSYISTTIISVHSLSHKIATKNAKDKALITPLENDSCIEGIIVPLDSNDTSGIFIDTEHRRKNGKYIHEESVLMIKTNVIKSIVDIDHFKKKTYIIEKQIEDLNINFNLTLTDKQKKQKESVILPHFKSQTIYQPESSIFYSPGSEDDLDEEDPDNDLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLJ2</accession>
    <name>M7NLJ2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA replication complex GINS protein PSF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02119</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GINS1/PSF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874100.1">
        <property type="nucleotide sequence ID" value="XM_007875909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLJ2"/>
    <dbReference type="STRING" id="1069680.M7NLJ2"/>
    <dbReference type="GeneID" id="19895812"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02119"/>
    <dbReference type="eggNOG" id="KOG3303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079191_0_0_1"/>
    <dbReference type="OMA" id="MFCEKAT"/>
    <dbReference type="OrthoDB" id="10252587at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11710">
        <property type="entry name" value="GINS_A_psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21696">
        <property type="entry name" value="GINS_B_Psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005339">
        <property type="entry name" value="GINS_Psf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056783">
        <property type="entry name" value="PSF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914:SF2">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914">
        <property type="entry name" value="PARTNER OF SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24997">
        <property type="entry name" value="PSF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="7">
        <location>
            <begin position="68"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein PSF1 C-terminal" evidence="8">
        <location>
            <begin position="148"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="197" mass="22905" checksum="29892247C5694C1F" modified="2013-05-29" version="1">MFGDLATKLILDAKRTQHLNQLPHYQTDLIQSIFKETDALNEASKELLTIHGGPEFSHSKNPGIATHLLIQHLCQLRNKRCLMAYHHTRLNRLNHISWFEINPFNIPWIATSLSPDEHLYLRKYITLLTHFKSQWMGIDFNGDLEPPKDLYINIRVLQDVGEIQTEYGAITLNKNSQFFLRQSDVEGLIQQGYLQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLV3</accession>
    <name>M7NLV3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CAAX prenyl protease</fullName>
            <ecNumber evidence="15">3.4.24.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PNEG_02231</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Proteolytically removes the C-terminal three residues of farnesylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.24.84"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 15">Belongs to the peptidase M48A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.84" evidence="15"/>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874215.1">
        <property type="nucleotide sequence ID" value="XM_007876024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLV3"/>
    <dbReference type="STRING" id="1069680.M7NLV3"/>
    <dbReference type="GeneID" id="19895924"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02231"/>
    <dbReference type="eggNOG" id="KOG2719">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025947_3_3_1"/>
    <dbReference type="OMA" id="FVIEEKF"/>
    <dbReference type="OrthoDB" id="360839at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120236">
        <property type="term" value="P:negative regulation of post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007323">
        <property type="term" value="P:peptide pheromone maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.10:FF:000002">
        <property type="entry name" value="CAAX prenyl protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 14 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 1 N-terminal" evidence="17">
        <location>
            <begin position="40"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="16">
        <location>
            <begin position="228"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMR09648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="439" mass="51324" checksum="398BE1309851CF6C" modified="2013-05-29" version="1">MDFLKDLGDDLDIPGFPWKKLIVSFILAQYVFEQFLVLRQYKKLKEKKPSPALENIVDLETYNKSQEYGRAKAKFGLVTELYELVQKLLIINYDFLPKLYDFVQLRVNQFFPEKFSGEIFYSLLFFFILNLQSLIFNLPVSIYSTFVLEEKFGFNKQTFSLFVTDLIKSQILIVIIGGPTLFIFLKIIAYFGQAFFFYLWLFIFIFQIILIVIYPTLIQPLFNKLTPLPEGELKLKVEELASNLKFPLKKLYVIDGSKRSAHSNAYFFGLPWNKHIVIYDTLIEKSETIEIIAVLAHELGHWALSHIAKMLAITQIHIFFIFMLFSVFIQNTSLYESFGFHSDKPILIGFVLYNDILTPINSLLTFLMNIYSRKNEFEADAFAAKLNYTKELSRALIKLHIQNLSTMDADKLYSSYHYSHPLLGERLHALGYKHESKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMB2</accession>
    <name>M7NMB2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL2m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_03423</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875509.1">
        <property type="nucleotide sequence ID" value="XM_007877318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMB2"/>
    <dbReference type="STRING" id="1069680.M7NMB2"/>
    <dbReference type="GeneID" id="19897110"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03423"/>
    <dbReference type="eggNOG" id="KOG0438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036235_3_0_1"/>
    <dbReference type="OMA" id="TAQRGNC"/>
    <dbReference type="OrthoDB" id="268576at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000128">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_uL2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 11" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="10">
        <location>
            <begin position="109"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="9">
        <location>
            <begin position="211"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="310"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR08256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="360" mass="40774" checksum="3DC42174130DFAF3" modified="2013-05-29" version="1">MFFNIFPKIRHKTLFHLKHYSDSYNRFKYIGYFFFLENNKLHNITIFFQDYKTTVEAPEQKIQGKQLPFLKKYKPVTPGRRGLCRPLNNHLWKGRPIRFLTIAKRKTGGRNNQGRITTRHQGGGHKQRIRIVDFVRKTPGPHLVLRIEYDPGRSGHIALIKDLKTEKLSYILAADGLRAGHVVESYRMGFNSYGEEQHEKIDSGTFITKAIQPGNCLPLSMIPVGTIVFALTTNMHGPAKFCRSAGTYAQILSTGNEGYATIKLQSGELRKISVHAAATIGIASNINWKHRKLGKAGRSRWLGIRPTVRGMAMNPRDHPHGGGRGKSKGNRHPCSPWGKLAKGKKTRKKLNPLVIKGRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMF3</accession>
    <name>M7NMF3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02029</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874009.1">
        <property type="nucleotide sequence ID" value="XM_007875818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMF3"/>
    <dbReference type="STRING" id="1069680.M7NMF3"/>
    <dbReference type="GeneID" id="19895723"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02029"/>
    <dbReference type="eggNOG" id="ENOG502R17J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_654024_0_0_1"/>
    <dbReference type="OrthoDB" id="196165at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000035">
        <property type="entry name" value="SH3 domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053039">
        <property type="entry name" value="Polarity_Bud-Selection_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="34"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR09848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="420" mass="48924" checksum="0B6D02B99B063DC4" modified="2013-05-29" version="1">MLLYKDHKEPFSDCNDYFDDNELSSSPSISDEDIDFNFVYALHTFVATVEGQANVIKGDTLILLDDSNSYWWLVRLAKDQTVGYLPAEHIETPLERLARLNKYRNAEISSITAEERVDNSILYNNTHVCNKDNKLVVFSVPTYIEYVEEEWDDNSKCADHDSEISEECEIHDYINENSDNYGDTYTDLNTRDVNIIQGRSCEMVLYDNSQNVSIASDLGDVIGNSCYKECNDITDRMYINKCKKKSKGKFSGISERNDKNEKEICKSLGKSCDSLENLRLENNSQVHNVFKNDDIKCNVTSLSYDINKGIYEIYDNDSDNIYTKSHDRDNFHLLNDIKYDTVLETSEVYNKNIYLSKGALRVYFDERKDLELYFFVNSMFSFDKNENIIYPEIHELYVNIEFELEKISQQLDTMLIKFKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMH7</accession>
    <name>M7NMH7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_03258</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875325.1">
        <property type="nucleotide sequence ID" value="XM_007877134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMH7"/>
    <dbReference type="STRING" id="1069680.M7NMH7"/>
    <dbReference type="GeneID" id="19896945"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03258"/>
    <dbReference type="eggNOG" id="KOG0740">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_378601_0_0_1"/>
    <dbReference type="OrthoDB" id="10251136at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036391">
        <property type="term" value="C:medial cortex septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035841">
        <property type="term" value="C:new growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035840">
        <property type="term" value="C:old growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19509">
        <property type="entry name" value="RecA-like_VPS4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000022">
        <property type="entry name" value="Fidgetin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000093">
        <property type="entry name" value="Fidgetin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF17">
        <property type="entry name" value="FIDGETIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="482"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="732" mass="83335" checksum="BCD215B069FB2F25" modified="2013-05-29" version="1">MNHRENIKNEILNLKELYKQIYIDRITAIESEKRGNIYQAILSYQSILKVVEKNSHIFKKPPIWSYKKSEKQIIEVVKMYVSQAELKISILSVFTKMDPNLFLSVNNNNHINKNVSSDFYPSKSMNHVSKEINECYSFSERNQRLSNFQKEDDIFRQSLRISNPNRNLFLENIFKSKNPKKELSKDDFSHVRKASQLKQFPQTLRQTKSRSSLIHNDAGKAAFCAWNSGTNSAIRPQKKYETNTNFSQRFIDSTIQLCSSLFSTSCRSSLRESYASETFPVQNDLKLNDLFNSQYIDNDNITDELSNSIFKQSLSSKTLASIPPRPSCFKDSNLDAKGQSDIQRNISSIAIQKSLQENASLVSLSQNKHKERHINFDTVKNQKCQNEITFISNSLKNTSLELENTKKLDIDKKETREQRAINNLKGIIDENLLQIIVNDIVIKGDKVSWDDIAGLEDAKKTLKETVIYPLLRPDLFSGLREPATGVLLFGPPGTGKTMLAKAAATEAKSTFFSISASSLTSKFLGESEKLVRALFSLAKELSPSIIFVDEIDALLSSRREDGNEHEASRRLKTEFLIQWSSLAKAVISNDESEPISRVLVLAATNIPWAIDEAARRRFARRQYIPLPERDTRMQQILHLLKYQTHTLSDEDIKNLVDITEGYSGSDITALTKDAAMGPLRCLGEALLTAKQDLIRPINLDDFKASLRLIRPSVSQKGLIEFERFNREFGIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMK6</accession>
    <name>M7NMK6_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873630.1">
        <property type="nucleotide sequence ID" value="XM_007875439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMK6"/>
    <dbReference type="STRING" id="1069680.M7NMK6"/>
    <dbReference type="GeneID" id="19895362"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01668"/>
    <dbReference type="eggNOG" id="ENOG502S74S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1797278_0_0_1"/>
    <dbReference type="OrthoDB" id="2014058at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="144" mass="16936" checksum="EF8EE8AB546502A8" modified="2013-05-29" version="1">MIGKMFFRQLLLQRFVFPIQRHNSIYSCYNRIKSISIHSKNDNSITGNYPSNIPFVNRQTRTPYDPEYFDVTERRKFGEILHEQDEILSMFSPDIHSHVTSSKAILHLFTFGFIVVTISSIAYIFRPKPLAAPRENILKKLERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMM9</accession>
    <name>M7NMM9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Required for respiratory growth protein 8, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_03308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875384.1">
        <property type="nucleotide sequence ID" value="XM_007877193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMM9"/>
    <dbReference type="STRING" id="1069680.M7NMM9"/>
    <dbReference type="GeneID" id="19896995"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03308"/>
    <dbReference type="eggNOG" id="ENOG502SG59">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_947043_0_0_1"/>
    <dbReference type="OrthoDB" id="3363286at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="35030" checksum="B2267546810C05F6" modified="2013-05-29" version="1">MKISRISTFSGYNVCLKLKVYEYIDKLVPLLKEPALNNCQKSFILNKNLRIKKPKIKKKRLQDEILDKDSDRWNRILRENPYVKLLISPIRRDILTDVRLPSAFFLSFLACKDPQTNKIWILPNGLKHKVVRKVGQSRWMICNKRHINFVGKKYWRRILPDFAPEDAIWRSDMDDFVLTELRKRVIMELKNVQNSFLNMLLINGTFVQDIKKGKLEKKIGCIIHKFDDDRIWYLENICNQEFKVPVINVSILFDPDNNENEWVKTLVFEKSTAIPLEINTVNAIFWIWKLRAYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMN8</accession>
    <name>M7NMN8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01706</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873670.1">
        <property type="nucleotide sequence ID" value="XM_007875479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMN8"/>
    <dbReference type="STRING" id="1069680.M7NMN8"/>
    <dbReference type="GeneID" id="19895400"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01706"/>
    <dbReference type="eggNOG" id="KOG4463">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057574_2_1_1"/>
    <dbReference type="OMA" id="RYRQFWR"/>
    <dbReference type="OrthoDB" id="272778at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF21">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="6">
        <location>
            <begin position="261"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="301" mass="34446" checksum="5C1364C55920AC07" modified="2013-05-29" version="1">MLSLTPSGLQNTPITQYLLYGTVLNATLASIFNIKHYFPIQLIPHFMNYHQYWRILGWQMIYINAGEVLFGTLTFYNLRIVERHFGARKYASFIILSFLYTSILTPLILCFIIKPLSQGRYQYLPAGPTALIFSILAQYHTIIPESYKFKVLNMPSAKKGFFLSNKIYLYILSFQLLFAESPGSILEAVTGWIIGRLYVFQYLPGVKWRIPKRIFEKIINNAPSIFTPRQTNNNEPERAIPTGTSILNAISGISERPELSGAREHEIESIVAMGFTRHQVVNALIRANNDVEMAIQILLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMS5</accession>
    <name>M7NMS5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_03264</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875334.1">
        <property type="nucleotide sequence ID" value="XM_007877143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMS5"/>
    <dbReference type="STRING" id="1069680.M7NMS5"/>
    <dbReference type="GeneID" id="19896951"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03264"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026447_0_0_1"/>
    <dbReference type="OMA" id="TNAADAW"/>
    <dbReference type="OrthoDB" id="1049195at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000145">
        <property type="entry name" value="Putative RNP domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000232">
        <property type="entry name" value="RNA-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000280">
        <property type="entry name" value="RNA-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF3">
        <property type="entry name" value="FI21236P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="97"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="208"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="337"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="436" mass="49426" checksum="64EA399C8F9DFC76" modified="2013-05-29" version="1">MGEENLSSISNPRWNEQMQDYRRRNRGSPYYHNRSRSWTPRRSYSPRNHSPSYHRPSRRRRSRSPLVTQGHRRHYDGRQAARNAMVNHIREASQQDRRVYIGNLSYDVKWHHLKDFMKQAGEVIFADVLMLPNGMSKGCGVAEYATRDQAQNAINTLSNQTLMGRMVYVREDREQEPQFGGPSQSGFRSFNNFHGDSRNTTYNSLNNRQLFIQNLPFNVGWQDVKDLFRSAGNVVRADIHLTPDGRPKGTGIVLFETAEEARNAQATFNRYDWQGRIIEVREDRFAGPPNFANRGFRGGYGGGFRTGHGNFNKNGYGNSIPPNEFTDGATANGDPSETIFVKNLPWSTSNDDLVELFITIGKVDRAEIQYEPSGRSKGTGIVRFDTVATAQTAISKFQGYEYGGRPLGLSYVKYLSGSNYEKSASGNDTIPTNTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN16</accession>
    <name>M7NN16_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytoplasmic tRNA 2-thiolation protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02998</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875048.1">
        <property type="nucleotide sequence ID" value="XM_007876857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN16"/>
    <dbReference type="STRING" id="1069680.M7NN16"/>
    <dbReference type="GeneID" id="19896685"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02998"/>
    <dbReference type="eggNOG" id="KOG2840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026481_1_3_1"/>
    <dbReference type="OMA" id="KPVRGIC"/>
    <dbReference type="OrthoDB" id="198857at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002144">
        <property type="term" value="C:cytosolic tRNA wobble base thiouridylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103016">
        <property type="term" value="F:tRNA-uridine 2-sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032442">
        <property type="entry name" value="CTU1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00269">
        <property type="entry name" value="TIGR00269 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807">
        <property type="entry name" value="ATPASES OF THE PP SUPERFAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807:SF12">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16503">
        <property type="entry name" value="zn-ribbon_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="2">
        <location>
            <begin position="7"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Cytoplasmic tRNA 2-thiolation protein 1 C-terminal" evidence="3">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="277" mass="32073" checksum="199F3FC75EF5B003" modified="2013-05-29" version="1">MKTLNDKYDYGLDLYMISVDEGIQGYRDDSLETVKRIQIQYSIPLKILSYEEIYGWSMDEIVKHVGRKNNCTFCGVFRRQALDRCATMLNIDHIVTGHNADDIAETIIMNLLRGDISRLGRCTEILTGEFKIKRSKPFKYTYEKEIVMYAHFKKLDYFSTECIYSSEAFRGFARTLIKELESLRPSSIIDIIHSGEAFLLSDAVKKNLPTQKNCKKCGYMSSNDYCKACILLEGLNSRISRSGIEEIKKSMIIEIMRNSIKMINNQKYEENQKGLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNC6</accession>
    <name>M7NNC6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Nucleolar GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_03098</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875153.1">
        <property type="nucleotide sequence ID" value="XM_007876962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNC6"/>
    <dbReference type="STRING" id="1069680.M7NNC6"/>
    <dbReference type="GeneID" id="19896785"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03098"/>
    <dbReference type="eggNOG" id="KOG2423">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011106_4_0_1"/>
    <dbReference type="OMA" id="KNPEDHI"/>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000200">
        <property type="term" value="P:regulation of ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01858">
        <property type="entry name" value="NGP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000559">
        <property type="entry name" value="Nuclear/nucleolar GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024929">
        <property type="entry name" value="GNL2_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012971">
        <property type="entry name" value="NOG2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08153">
        <property type="entry name" value="NGP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="200"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="478" mass="55549" checksum="56429832FD57028C" modified="2013-05-29" version="1">MKKEKNKKEDKARPKIEKRVSQHIKGENFYRDAKKVKWVRLLKSGKAKRNKKGKIIKPGEFQSKDIPDARIQPDRRWFNNTRVISQDVLNMFRESFTEKLNDPYKVLLRQNKLPVSLLREPTKTRKANIIDVEPFDDTFGPKSKRKRTKLYTSSMENLSNFASESYENYIKKNCEYENVNKNIQKSYDKIFSKGTSKRIWNELYKVIDSSDVIIQLLDARNPLGTRCKHIEEYLKKEKPHKHMIFLLNKCDLIPTWCTREWIKQLSKEYPTLAFHASINNPFGKGSLIQLLRQFSKLHSNRRQISVGFIGYPNTGKSSVINTLKSKKVCNTAPIPGETKVWQYVRMTSKIFMIDCPGIVPPNSNDSETEIIIKGVLRIEKVSNPEQYIRAILNLCETKHLERTYQISGWENDSTKFLELLAQKTGKLLKGGETDESSIAKMVINDFIRGKIPWFIAPVQESKLSNIELSNNTLVEKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNG5</accession>
    <name>M7NNG5_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_03596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873600.1">
        <property type="nucleotide sequence ID" value="XM_007875409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNG5"/>
    <dbReference type="STRING" id="1069680.M7NNG5"/>
    <dbReference type="GeneID" id="19897283"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03596"/>
    <dbReference type="eggNOG" id="KOG2226">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007392_0_0_1"/>
    <dbReference type="OMA" id="TANSGWM"/>
    <dbReference type="OrthoDB" id="432953at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026705">
        <property type="entry name" value="Hid-1/Ecm30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575:SF12">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12722">
        <property type="entry name" value="Hid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="878" mass="102515" checksum="CC953FEDA5FAD091" modified="2013-05-29" version="1">MGAQESKFLFRRGIFRLFEESISVDNEYWRQFWTLPESVKDVFTLFSTQDIIRIRDYSETNIRTLVYVVASKLVFIKDEIDKPEKMKEALNCLRIITRVMPFIYEKESMEEWENETFWNYRCRKKKFKYYKNSNLTLEESNLSKDEIDFKSHLKYTKIIVNDIYEKENDPEYEILKPLAEELLDTLNDMLFFAGFTISAKENVIRKISYSVWEPGIGCITSTKATTEYELNRIEVLRCILSIISKSIYFYPNKQKPNLYIIYLVTNPDKRFILTFLCSLLNTVINYNPAKWQIFYNHIISLDSKQLLVSYCLQILLIFLDYQIPSLLDIEKSQTSEIPVNKYCMYFGKLHHKDDIEFLYNGINRILTQFLHNDSYFPTIEKPMKYSPEVIILLWKVFQINNSFKEYLIDDKNSLDYLVLLLCYSVNYRKELSKFGLIRICISILQTLSTKPSFCKKLNTTFEHYKILPINIKIISKDNYMDFIIISIYMLIMTSKGALNSLLPYMLSILINIAPYAQNLSILSCTKLMQLFYSFSSFNFLLASENNHILLGNLLEVFNRIIEHQMKKNLHLIYAILRSSERFELLKNFTLEKALMELGKDSEFKKNELNNLKNDTKKFHKDNTYFSEKIQMPETPFQNDNSSSIIENEELNNEEENSENTIVNDKLSKGKSSLSLIGTSTSASEFHKINNSFISEKARGKLPERLNSPSDYTETDPFHFNTYASKNILKTKKKFIPTEDWVKSWHSSLELDTILTIIKQLKPKINDIAFSTPNPNIILEALSSLSIDFDITDTEPIPFIRNDHTLTTVEGLLWGHIYVAETKFSTGAIGIWTGTSIKLFRIQETKHSPSLLSPKGAVDAVAKSVIDKVGNLNFYTKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNN9</accession>
    <name>M7NNN9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">E2 ubiquitin-conjugating enzyme 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ubiquitin-protein ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_01554</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873503.1">
        <property type="nucleotide sequence ID" value="XM_007875312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNN9"/>
    <dbReference type="STRING" id="1069680.M7NNN9"/>
    <dbReference type="GeneID" id="19895249"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01554"/>
    <dbReference type="eggNOG" id="KOG0426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_10_1_1"/>
    <dbReference type="OMA" id="APDGMFT"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990389">
        <property type="term" value="C:CUE1-UBC7 ubiquitin-conjugating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000837">
        <property type="term" value="C:Doa10p ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000839">
        <property type="term" value="C:Hrd1p ubiquitin ligase ERAD-L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180027">
        <property type="term" value="P:inner nuclear membrane-associated protein degradation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23796">
        <property type="entry name" value="UBCc_UBE2G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000008">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0882">Thioester bond</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="13">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR10293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="165" mass="18772" checksum="0CC325BD2BB4C744" modified="2013-05-29" version="1">MTSTALRRLFTEYKELISNAPHGIMAGPMNENNFFEWECLLEGPQDTPFEGGLFPAVLKFPRDYPLNPPVMKFTCEMFHPNVYPDGTVCISILHAPGDDPNMYESSSERWSPVQSVEKILLSVMSMLAEPNDESGANIDACKIWRTNRSEYDRIVRQNVRKILGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNS6</accession>
    <name>M7NNS6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peripheral subunit-binding (PSBD) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874718.1">
        <property type="nucleotide sequence ID" value="XM_007876527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNS6"/>
    <dbReference type="STRING" id="1069680.M7NNS6"/>
    <dbReference type="GeneID" id="19896385"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02694"/>
    <dbReference type="eggNOG" id="KOG0557">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_839693_0_0_1"/>
    <dbReference type="OrthoDB" id="202158at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="2">
        <location>
            <begin position="147"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="331" mass="39039" checksum="BC4A52EC82CF29C0" modified="2013-05-29" version="1">MFSNFSSFFLRFIDKDSLKIIQTKGNNISFERWYHKYLFSPEKRYKSSKNSLNTFFKNVLIRNFNSDKSIFRKGFFRIKLSKTLMYFNTLNHGILPIISMPEYMYIKNGMDKFQFQKKRSIFTDRINRNDILVKDIMEDRLKNPVTISSPAVLSLIKHYNITNPFEIKTTGPRGRLLKGDILAHVGAINKDFPLKLVKIIEEKEKLDLSNLKIKPKQPIENSFISIIIPVCLKSLLSMKESINEKLNIKIELSDLINKAIYKGSQKVPSIFLKKPSRQEILFSNVLEEIPKYYNCINVNINNEDFQIDYIKDKKTNVLWASPKIIRWFYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNV6</accession>
    <name>M7NNV6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar membrane-associated protein IML1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Vacuolar membrane-associated protein iml1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02942</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IML1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874987.1">
        <property type="nucleotide sequence ID" value="XM_007876796.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NNV6"/>
    <dbReference type="GeneID" id="19896629"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02942"/>
    <dbReference type="eggNOG" id="KOG3572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SWMNATP"/>
    <dbReference type="OrthoDB" id="39497at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04449">
        <property type="entry name" value="DEP_DEPDC5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045838">
        <property type="entry name" value="DEPDC5_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048255">
        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057068">
        <property type="entry name" value="IML1_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19418">
        <property type="entry name" value="DEPDC5_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24438">
        <property type="entry name" value="IML1_N_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="DEP" evidence="7">
        <location>
            <begin position="1092"/>
            <end position="1167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1465" mass="170115" checksum="ACBE5B71448132D7" modified="2013-05-29" version="1">MQGAVLTLWVHDRSFSNHDVIINEDLVPGLSASSAIEIRQTGYESSPKLLGLGGKQMGISRNSRRLFAIPTFLEGDLKKKQSNLQISISTTLSAAFGLRNRIYVKVTIVEDKMSISADYIVIYFKDQYISRSDMWNLSQDLQGKCIWKREKMIFSGSLRADIREIWINGKKKHSAYVSTKTKPIFRSESAKCFLFLQMSKEMWEFEEDGELFFDKAIDGFLPELFKRWKNMGTRHSVTIILFTRVYYDGIGPFCLSQSQENYCSSQAQKIIRNYKDYYETCSKYSQDFFKIVFDNVFSGECMTTISELKQELQKFKKDVLMYERINELSHESMGLVSASMSYALQGNVLEAINIVTKQFCYDYIDHDLIRTGASIVIVTPGTGHFEVDEKMLEITAKNLISTGIEIDFICLSKPPLHIVPLFRYKKKSSNEINNSQDADNISVYPSSSLNLNMSNKNLFSSLHQHESWVYAVPYFCQVSYWNYKTKKNTSFVTSCKMHELQMMGIMENEASKIAIEYLPEFDLLDDGKISSYCEEYDENVFRINRKDNNSLNNEHLDEKEKILKNRSFSQKTDLENISTLNDDVKKQAKYKESDKEPFSVHKKVDKVASKAHTLSKRYFVQNILSMGELFSSQYLKALPSITSVSFLATQKKPTTKKLTTKSNQLESNETDFLISQNNPQYPYIFQSRLDSKKDSIKNKINTIMSKQPEKIMDIRKSLSLEKFQKLKPEKDSFWQIIQYPSNPLSNPPPSDVYYKKWKDAHPKQRNIEEVNWSSICSPASLPLSTDLFPSAEELRELYQDYTYTITIDPEKVSFDQHSLLIELINLRLNQGFQIVIGDSVLADDPKSIILSQHSPVCKLNKKNTLQGPLDNFYKTIYLALDNYQFHKITGDFSGYNIQVKRFIRKYSPIGPINYKYHTWFLSNSGYQPRSITFSSHPFENQNWNYVDQLIAGQEDNLSDSIKYWRSRFVLIPVDIKTMPVHQILTYFNANSTDVLTDEEIRILGILKIYELIKKGQYLNSFERDRIKHTSWKDGNNMDLIFITSNIPAFIIQEIESFDSEYNFQNKENSNTGNEKLKTLDAKLNSIAQEIQGPRGIKFQDRRWHLKLYENCFIGMDMVTWLLENFSDISTREEAVYYGNELLSKGLFEHVNNDHQFLDGYFFYRLKPEYSSSKTPKCWFGTRKITPINAVSGNLSRSDSIASNYQISTSTKKIQKVILSKYLIYDVDTQKQSYRPECIRLHYDRIYNPKSCYHIRLEWVSVTSRFVENTIQSWKRIAEKYGLKLVEVPIDEACKINDKNPLQSTISIKLVLPPPPVPHLIKSDEILGEDPDFWCILLLRKFDFVLDFESASKFPKSIDITYSWGKPSYKYSQYIHRSGAAIAQIADDNTILWLTNQLYLSRIGFMVHAPNQYNIESQRNIKDLTLESNKLCADFIKFCSDKVSLEKFYEEILAKYTLKQETNESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP21</accession>
    <name>M7NP21_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02633</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874652.1">
        <property type="nucleotide sequence ID" value="XM_007876461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP21"/>
    <dbReference type="STRING" id="1069680.M7NP21"/>
    <dbReference type="GeneID" id="19896324"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02633"/>
    <dbReference type="eggNOG" id="KOG2713">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029244_1_3_1"/>
    <dbReference type="OMA" id="GWGQFKP"/>
    <dbReference type="OrthoDB" id="15808at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070183">
        <property type="term" value="P:mitochondrial tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000002">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050203">
        <property type="entry name" value="Trp-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR08846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="373" mass="42353" checksum="F6DBC9891C213872" modified="2013-05-29" version="1">MSIIHFFGKRPHACLNFFFLMQQYRFNIQRLFTKDALERRIFSGIQPTGVPHIGNYLGALKQWVDIQNSAESSTILLFCIADLHAITMLKKSVVLKKYKREMFASLEAIGIDMKRSIVYEQSSVSCHSELAWILNCVLPVSHLQRITQWKTKSLLKNRNSVLNLGLFAYPVLQAADILLYRTTEVPVGEDQIQHLELACTISRLFNNAFSKNIFIPPKVTLTPSKRIMSLRNPYKKMSKSDPDLNSRILITDPLDVIESKISQATTDSYYGITYDPDKRPGIANLLQIIASLSHPSSDPIEIAKDNANISHKAFKNLVVSSINTFFSPIREHYQSIMARDIFSYIEQNKIGAQKAQKLALHTMDQVKICTGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPD7</accession>
    <name>M7NPD7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">V-type proton ATPase subunit e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_01278</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase e1/e2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873202.1">
        <property type="nucleotide sequence ID" value="XM_007875011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPD7"/>
    <dbReference type="GeneID" id="19894975"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01278"/>
    <dbReference type="HOGENOM" id="CLU_170555_1_0_1"/>
    <dbReference type="OrthoDB" id="1508846at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008389">
        <property type="entry name" value="ATPase_V0-cplx_e1/e2_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05493">
        <property type="entry name" value="ATP_synt_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR10573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="64" mass="7099" checksum="EF0851F40A589656" modified="2013-05-29" version="1">MSSSVIVVGLILGLISWFAYKQTLDESQRIGRVVLILSLVVCYLIWAITYLAQLHPLLVPQKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPI8</accession>
    <name>M7NPI8_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873252.1">
        <property type="nucleotide sequence ID" value="XM_007875061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPI8"/>
    <dbReference type="STRING" id="1069680.M7NPI8"/>
    <dbReference type="GeneID" id="19895023"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01326"/>
    <dbReference type="eggNOG" id="KOG4843">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_531126_0_0_1"/>
    <dbReference type="OrthoDB" id="3596986at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013951">
        <property type="entry name" value="Rxt3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08642">
        <property type="entry name" value="Rxt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="513" mass="59010" checksum="D63DFE79FC1A250D" modified="2013-05-29" version="1">MQKQEKNQNEFLESKSHICCSETRKNDEQSENETIKDNIKTFNTLNTCQLNQKASDVSLFQSTDSYEKNPASSRNTSIFNKSSKESPTKSNQSLPSISSLSFHHPMMSIQSVLGEEPISWNTNTESSNKNFSTETINNEIDNRGAVSSLIHPYSNEFFHPNINMSSTRPINQHHSFNNILIHEDEAYQKKQSCVGYQHFHSFNQSSQLPFPLFSNNVIIPSTLPSLFQGHQPLNQNIDRGKLYPMNHMEENYNSPTSKVKFSNKSNTSPKAQKNTRFRSNLGTKSADYHENEYKVRPLTRHKSHETNQSSYKTNALNTPVKTSQETSQKKSQKDTKKQLQPKEPLPRPKLIVKNDAVMNFIKDMEEKDLGEYIYTPSSPIPCLDGKLNGILTIRIARQYFHKSENDKIKKRALWGTDIYTDDSDIVAILLHTGRLGRKKPSSDAIVKVRVLPRLIKYSGSLRYNIMSRGWKTRHDGESIMIEDLKWVEDKTKRKGRKDMKERIAARYQLQLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPK4</accession>
    <name>M7NPK4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein transport protein SEC22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PNEG_02526</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874536.1">
        <property type="nucleotide sequence ID" value="XM_007876345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPK4"/>
    <dbReference type="STRING" id="1069680.M7NPK4"/>
    <dbReference type="GeneID" id="19896218"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02526"/>
    <dbReference type="eggNOG" id="KOG0862">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054453_4_1_1"/>
    <dbReference type="OMA" id="FIYWRFF"/>
    <dbReference type="OrthoDB" id="1719357at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15866">
        <property type="entry name" value="R-SNARE_SEC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000007">
        <property type="entry name" value="SNARE complex subunit SEC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044565">
        <property type="entry name" value="Sec22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45837">
        <property type="entry name" value="VESICLE-TRAFFICKING PROTEIN SEC22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="17">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="18">
        <location>
            <begin position="134"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMR09187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="215" mass="25221" checksum="1928C3A5896BC81F" modified="2013-05-29" version="1">MVKSTIIVRVTDGLPLCASVDDKHSEIELLEQKQQCKVIFRKLTINSEIRASIESGQYFLHYFIDNNVCYLCICDKSYPRKLAFSYLDEISKEFWNVYGNDVTKLSLRPYAFVQFDTFIQRTTRLYLAPRASSNLDKLNNELQDVTRAMTKNIEDLIYRGHSLDRMSNLSSDLRSESIKYKKAAKNINFHAFLRHYGAICTIVFIIVLVIWWRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ70</accession>
    <name>M7NQ70_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH-ubiquinone oxidoreductase 12 kDa subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874595.1">
        <property type="nucleotide sequence ID" value="XM_007876404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ70"/>
    <dbReference type="STRING" id="1069680.M7NQ70"/>
    <dbReference type="GeneID" id="19896272"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02580"/>
    <dbReference type="eggNOG" id="ENOG502SBS6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142967_1_0_1"/>
    <dbReference type="OMA" id="GYQKNDP"/>
    <dbReference type="OrthoDB" id="10252718at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039993">
        <property type="entry name" value="NDUFB10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE PDSW SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="10859" checksum="2EE3F36E0234ABAA" modified="2013-05-29" version="1">MKKHEQVLFDEIDYDDKEALQAAKLYAVRESWIQAMELRLVRDKLDKCYKIEGVNHYENCKELSERYWNMLRQGHKVKGYMSKERMIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQC4</accession>
    <name>M7NQC4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874230.1">
        <property type="nucleotide sequence ID" value="XM_007876039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQC4"/>
    <dbReference type="STRING" id="1069680.M7NQC4"/>
    <dbReference type="GeneID" id="19895937"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02244"/>
    <dbReference type="eggNOG" id="ENOG502S8YW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015602_2_0_1"/>
    <dbReference type="OMA" id="MTWECLA"/>
    <dbReference type="OrthoDB" id="303107at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031213">
        <property type="term" value="C:RSF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028938">
        <property type="entry name" value="Rsf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296:SF3">
        <property type="entry name" value="DIKAR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296">
        <property type="entry name" value="REMODELING AND SPACING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="265"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="589" mass="70288" checksum="49EB5C1217C15FDC" modified="2013-05-29" version="1">MNYRKDSNTDSIIHALRNMLEFAVLGQFLCLFYKILKLDDFDIEFFEQELLGFHEPRTLTIIRYGLVRYLSSNRHINAENVDFYTRKQFLLRKPEDNPYGNEEIPYSWDSFDIFTKVQVLLQLCEWQLLNPEKFRERVGARESDEISWRIDPIGRDSVGYTYYLLDDNRLYRCLHTFPHSSNEELRENDKRYKRKRKRIVVDDDVDSLEDSAINNEKPQKPQIGHWENVCVTFNDWKNFVDSISHSRNKNEYILHNYLQKNILPYLQENEDKKEKERQLKERERLKAEALIHRKKSTRIEQKKLMKLQEEKRLKQKQLAMLIEERGREEKHSTEYNRGSRIETRDRKQKEKFLKEFLQKEDNQKNDISSFNYSYSNSLKNYQILRKSTKKIKRKAIENKKTENSDWIFDCICGIFGKNYSDDELMISCDKCMVWEHVKCQHNAHEIFLDLQKQTNEDNCIPFICNKCDRKLKNAQQNPKNIVEENKITVPETLLSDIPNKMIVSSSTEKIPSNNDINTINEYISKIHSNVHDISESFDVGNYPQTQISYSQITNLSTLQRNEIKAFKSFYSLESTLHIQNISSSLEDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQS3</accession>
    <name>M7NQS3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="13">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PNEG_02400</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="13"/>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874404.1">
        <property type="nucleotide sequence ID" value="XM_007876213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQS3"/>
    <dbReference type="STRING" id="1069680.M7NQS3"/>
    <dbReference type="GeneID" id="19896093"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02400"/>
    <dbReference type="eggNOG" id="KOG0216">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_5_1_1"/>
    <dbReference type="OMA" id="FFGVVHY"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000016">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000007">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009674">
        <property type="entry name" value="Rpa2_dom_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06883">
        <property type="entry name" value="RNA_pol_Rpa2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="17">
        <location>
            <begin position="31"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="200"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="459"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase I subunit RPA2" evidence="19">
        <location>
            <begin position="563"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="14">
        <location>
            <begin position="671"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="15">
        <location>
            <begin position="1037"/>
            <end position="1158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF06883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMR09456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1163" mass="131970" checksum="733038D1C39E59B9" modified="2013-05-29" version="1">MGIQSFHTLEREKLFQNPRREPAYPDLLAITAPHIESFNALTDDQLLNLAVQDIGKKSVFDRKNGGLGNKLSFRVEEVQIAKPTLPTRERTSINRKILPSECRERFCTYKARLLLKLAWSVNDEEETTEVREFGQIPIMVKSNRCHIEKLSPADLIASREESEELGGYFIINGNEKIIRMLIVPRRNYVMGLIRSSFTNRGAHYTHFGTQIRCVRPDETSQTNTLHYLSDGNCIFRFSWRKNEYLVPVIMILKALINTNDKEIFDSIIGSDRENTVLIDQVEILLRTYKNYELYTQEQTLQYLGEKFRIILNLDEDLTHVSIGEKLLKKVVLVHLENNYDKFRMLIFMIQKLYSLVSGDCCQDDPDSLQHQEILLGGFLYGMIIKEKIEDYLYSLKNTILQDLRKPNNSVNFFEKKYISKLFQRVPNDIGSKLQYFLSTGNLVSSSGLDLQQTTGFTIVAEKLNFYRYLSHFRMVHRGAFFADIKTTTVRKLLPEAWGFLCPVHTPDGAPCGLLNHLTSKCKIVTSNINIDSIPCLLVSLGVNPTSNIVSTEYSCVQLNGKIIGYCTNKLASHIAQLLRHWKVENSHNVPLQLELGLIPKSSGGQYKGLYIFSSRSRMTRPVKYLALNKEDIIGSFEQVYLNIDIDSHFSGKIDSQYSHSELNTSNIFSIIASLTPFSDFNQSPRNMYQCQMAKQTMGTPASSLRYRTDDRLYLLQTGQAPIVRSKTYDLYGLDNFPNGTNAVVAVISYTGYDMEDAIVINKSSYERGFAYSTIYKSEKVNLTQKRQKGEKIIYHFGFGNDKLHPKWIEKLDADGLPIIGIKLEDGDPLAAYFDETTGKTMIHEYHGIEDVFVEEVRLLGNDSGDMECQCIHIKLRISRPATIGDKFSSRHGQKGVCSQKWPAADMPFSESGIQPDIIINPHAFPTRMTIGMFIESMAGKAGALHGLVEDSTPFTFNEKNTAVDYFGKQLIKAGYGYNGNETFYSGITGDIMEAEIFTGIVYYQRLRHMVSDKFQVRSTGPVHSLTHQPVKGRKRAGGIRFGEMERDSIIAHGTAYILQDRLMNCSDYTRTWICRPCGSILSLTPTMTMAGTGNSFSSNIRCRLCASEVTGFENDCDIWQDSTGKKFRGGDNIAIIALPYVFKYLATELASMNIRLKLNINKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NR12</accession>
    <name>M7NR12_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01879</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873853.1">
        <property type="nucleotide sequence ID" value="XM_007875662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NR12"/>
    <dbReference type="STRING" id="1069680.M7NR12"/>
    <dbReference type="GeneID" id="19895573"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01879"/>
    <dbReference type="eggNOG" id="KOG4400">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_765299_0_0_1"/>
    <dbReference type="OrthoDB" id="7608935at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051644">
        <property type="entry name" value="TRAMP_AT-DNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="362" mass="42643" checksum="D81373685D560B07" modified="2013-05-29" version="1">MSNCFKTSKIEQDELRDNKGDLSKLSFDNCDWKFNGDLLNAFEGKKSEEKEKNEAFVHDEEPVCKNELNLGSLGLKNQEITENENLEDLKSDIYEESENTDTIEDWAQLSKGRYFGLAQDEIICHKCAEPGHIARDCFQEMCTNCGTVNDHLASRCPMLQKCHNCNELGHILIDCKKPRKINICSTCSSKYHPDDMCPKIWRCYTFNPDAPKEFTPKRYCYNCAEYGHYGDDCRLPQYSRYLESSAFCIDNEPIPASEYEYIKHREIIKKKKLLKTYREYEKEDWFARKMKKKCLDHKSPKLDTFRSNKSYNKINYLNGVHNRRDELLYNNSDKQQNNKYDKKRLKRNLNKGKSIFIDLIPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRC5</accession>
    <name>M7NRC5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00293</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872165.1">
        <property type="nucleotide sequence ID" value="XM_007873974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRC5"/>
    <dbReference type="STRING" id="1069680.M7NRC5"/>
    <dbReference type="GeneID" id="19893991"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00293"/>
    <dbReference type="eggNOG" id="KOG3949">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040685_0_0_1"/>
    <dbReference type="OMA" id="QGMLKVH"/>
    <dbReference type="OrthoDB" id="289162at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140018">
        <property type="term" value="P:regulation of cytoplasmic translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19494">
        <property type="entry name" value="Elp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008728">
        <property type="entry name" value="Elongator_complex_protein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896">
        <property type="entry name" value="PAX6 NEIGHBOR PROTEIN PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05625">
        <property type="entry name" value="PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="353" mass="39509" checksum="048D7D0EC78A3508" modified="2013-05-29" version="1">MSFKKRITPKSQNTEKTCKTFSLYTEKSLKNGVCPSPLNGIHITSSGCSSFDSITGLGGLPLGTSFLIEETGTTDFSSSLLRYFVAEGILHGHGIWVGGVPRTWLQNLPGESTMHFEKNRQSNDAMKIAWRYCHLGGFEGNIGLSRGPGIYKFENVPYCHTFDLAKQLEIPENTTIICSKCIATSSKPYSEFISDILKLLSSKSPEIIRLIIPNILSPAFYPSEALKQKNILEFFHTLRALLRIYSNRLVAIISIPTQLYSRETGIVRYLELLSDGVLELIPFSNFDSTNGFQGLLKLHKLPFSQNSINYNNDLAFKVTRKQFSIEPWVLPPANEKESYTGEKTINTSVPVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2024-01-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRQ7</accession>
    <name>M7NRQ7_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872334.1">
        <property type="nucleotide sequence ID" value="XM_007874143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRQ7"/>
    <dbReference type="STRING" id="1069680.M7NRQ7"/>
    <dbReference type="GeneID" id="19894151"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00453"/>
    <dbReference type="HOGENOM" id="CLU_2185085_0_0_1"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="109" mass="12761" checksum="1428E314722B8C00" modified="2013-05-29" version="1">MSIDEAGLLRVQELIEESYKNLEDTSIQQKAFQESLKYLGGLGEDEHWFCTNKLDALIKESLQLFMFSKSDALLWLKTKIRVQLGRCYSCIKHYHILKDEIETSYEGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRX1</accession>
    <name>M7NRX1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874007.1">
        <property type="nucleotide sequence ID" value="XM_007875816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRX1"/>
    <dbReference type="GeneID" id="19895721"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02027"/>
    <dbReference type="HOGENOM" id="CLU_754636_0_0_1"/>
    <dbReference type="OrthoDB" id="5386950at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="367" mass="42715" checksum="64C3B94AEC874DC4" modified="2013-05-29" version="1">MEEKDIEDLNRYILITKQRHEYELLKSATTKIQMQEENRRARLEIVILTNEKNEMLQSEIIHRQTIKELTEDFQKLQNQYFITEQKNDELNSKVKEYEKKLSHLQNNTLKNNTFVSQDNVLLQRIEFLEKELMNEKSRQNVQNVITEDFESNNFSKTPELNLKNSEKANSIIKTVNKDNESNISTIKNNKLKSVKHLKMKKSNKVKIKENIDIDKYSFNNHSETLKKKDGSMSNIFQVKNNTQVYDPIKSPVVPIKSKKDELKPESAISTFSITPFLDRTNINTKNLLFSPLESNKLETRMILTGDKLKTKKQSISKKKRKLGAIGKTLFDETPKGLINSVFLQNVSPLKHGKKITIQPFATITAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NS04</accession>
    <name>M7NS04_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial resolvase Ydc2 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873609.1">
        <property type="nucleotide sequence ID" value="XM_007875418.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NS04"/>
    <dbReference type="STRING" id="1069680.M7NS04"/>
    <dbReference type="GeneID" id="19895343"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01649"/>
    <dbReference type="eggNOG" id="ENOG502S4DK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042191_0_0_1"/>
    <dbReference type="OMA" id="GITWLEW"/>
    <dbReference type="OrthoDB" id="5552842at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000402">
        <property type="term" value="F:crossed form four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16963">
        <property type="entry name" value="CCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039197">
        <property type="entry name" value="Mrs1/Cce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015242">
        <property type="entry name" value="Ydc2_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28072">
        <property type="entry name" value="CRUCIFORM CUTTING ENDONUCLEASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28072:SF1">
        <property type="entry name" value="CRUCIFORM CUTTING ENDONUCLEASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09159">
        <property type="entry name" value="Ydc2-catalyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondrial resolvase Ydc2 catalytic" evidence="1">
        <location>
            <begin position="59"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="320" mass="37559" checksum="B8450D0560743431" modified="2013-05-29" version="1">MLSHKLVSDLQQLTLPQLRIIAIKCGILNKGNKLELAQRILQEISKTRLINNNFTPHRILSIDVGIRNLAFSSIIAPSIIIEDFNLIHHKPFVVDGWDKLSIESKKIDNKIIKKAYNPSKFSFLAYQLAKSLLKKFKPQTILIERQRCRTRGKNVVQEWIIKINIFENMLHSIFRCFKEEMIWNDQEADILSIDPAKISSFWFEKNNILMKNFPINHNLPMPIDSKDKKPSYLSKTSTLRSKKEKIEIINSWLKAGSIFDFRNTQITAKDFISKKKEKDKLKIDDLADSLLQGISWIIWEQNKWILKQKLQHNKPLYDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M7NS81</accession>
    <name>M7NS81_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873698.1">
        <property type="nucleotide sequence ID" value="XM_007875507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NS81"/>
    <dbReference type="GeneID" id="19895429"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01735"/>
    <dbReference type="HOGENOM" id="CLU_2085792_0_0_1"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="117" mass="13839" checksum="CE7AE0C007EF2C6D" modified="2013-05-29" version="1">MLLESFSVSPTLNVISFARLNISNSITFLSEYLQTSRRINIDNPAENNVNESLETQLTFRNANINAQLYKIQEYLKKAYEDKKLLKRKKTQTLKKVNKEKKQMKGKKEKSYRNKKEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSL1</accession>
    <name>M7NSL1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01516</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873457.1">
        <property type="nucleotide sequence ID" value="XM_007875266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSL1"/>
    <dbReference type="STRING" id="1069680.M7NSL1"/>
    <dbReference type="GeneID" id="19895211"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01516"/>
    <dbReference type="eggNOG" id="KOG0183">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_4_0_1"/>
    <dbReference type="OMA" id="ICMLDHH"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03755">
        <property type="entry name" value="proteasome_alpha_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000004">
        <property type="entry name" value="Proteasome subunit alpha type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 3 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="5">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="247" mass="27278" checksum="22D644977E2D797A" modified="2013-05-29" version="1">MSGSYDRAISVFSPDGRLLQVEYGQEAVKKGATCVAVKGKDSVVLGVEKKTALKLQDTRTAKKIGIIDHHVCLAFAGLNADARILLDKARVEAQSHRLTIEDPVTIEYITKYIAGVKQKYTQSGGVRPFGVSTLIVGFDPNDVVPKLYQTEPAGIYTSWKANSIGKSSKTVREFLEKNYKENMDRNEAIKLAIKSLLEVIQTGSKNIEIAVMSYGKKIEFLTCDDIDAVIKEISAEKEQESNRKKTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSQ7</accession>
    <name>M7NSQ7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-type lectin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872068.1">
        <property type="nucleotide sequence ID" value="XM_007873877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSQ7"/>
    <dbReference type="STRING" id="1069680.M7NSQ7"/>
    <dbReference type="GeneID" id="19893898"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00200"/>
    <dbReference type="eggNOG" id="KOG3839">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053733_0_0_1"/>
    <dbReference type="OMA" id="WYTSERG"/>
    <dbReference type="OrthoDB" id="10265193at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07308">
        <property type="entry name" value="lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF28">
        <property type="entry name" value="LECTIN, MANNOSE BINDING 1 LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012226653" description="L-type lectin-like domain-containing protein" evidence="7">
        <location>
            <begin position="16"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="8">
        <location>
            <begin position="10"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="386" mass="44979" checksum="DDC391342E37C14C" modified="2013-05-29" version="1">MIFILILYFLNVINCYDSRMSLFSPFEESLSENWDMYGSVKIQENRIVFISPEYELNTGSIWQKHRNIHEEWYAKISLSLTHIESENFGFALWYTSERGKTGIVFGSKDRWDGLGIFLNIGLNKKPSIRGHLNDGSMEYSKFKNPLIQAFGACSIIYQNPNETLTFKLSYSRGIIQIELNDTICFKTTQINLPSDYYFGISTQSENGTESLEIYSFEVDEMKNNYVDSNEYIYTDIHKEDKNIKNDSNSNSAKILNDLPTLLNQLLNITNEQLIIKNTVKNINESLNSLSKAISNSESKLYRNEEEIINIFSDKMSRSISYLLEYKQRNETFLMLNLLSESIAEKITSINSNIKFFIIINIIIQIILLLTYIIYKRRTDEYPRKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSR8</accession>
    <name>M7NSR8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14 15">Diphosphomevalonate decarboxylase</fullName>
            <ecNumber evidence="3 14 15">4.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PNEG_01566</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(R)-5-diphosphomevalonate + ATP = isopentenyl diphosphate + ADP + phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:23732"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.33"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:23733"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 15">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 15">Belongs to the diphosphomevalonate decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.33" evidence="3 14 15"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873517.1">
        <property type="nucleotide sequence ID" value="XM_007875326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSR8"/>
    <dbReference type="STRING" id="1069680.M7NSR8"/>
    <dbReference type="GeneID" id="19895261"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01566"/>
    <dbReference type="eggNOG" id="KOG2833">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040369_4_2_1"/>
    <dbReference type="OMA" id="LTLHAMM"/>
    <dbReference type="OrthoDB" id="10253702at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000018">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029765">
        <property type="entry name" value="Mev_diP_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053859">
        <property type="entry name" value="MVD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01240">
        <property type="entry name" value="mevDPdecarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977:SF3">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22700">
        <property type="entry name" value="MVD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8 15" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Diphosphomevalonate decarboxylase-like N-terminal" evidence="17">
        <location>
            <begin position="8"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Mvd1 C-terminal" evidence="16">
        <location>
            <begin position="192"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR015950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMR10307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="382" mass="43018" checksum="29F350FEF479D566" modified="2013-05-29" version="1">MHKKSVKAPVNIAVIKYWGKRDKELNLPMNGSLSVTLSISKLYTLTSVACCREFEKDRFWLNGKEEKDLSERMKTCLSLLRSLRYSKESKDSKLERLSEQYLHIVSENNFPTAAGLASSASGYAALIKGIAELYELDQSSEELSCIARQGSGSACRSLMGGFVLWKMGVLKDGSDSFAEQIASKSQWEDLRILIIIVSSSSKKVSSTKGMQATVLTSNLFQYRIKHVDFYIKKMENAIKHKDFESFAQLTMKDSNQFHATCLDTFPPVFYLNDISTSLIQLVHEINRLSKKTIAAYTFDAGPNAVIYFLKENEDLLLGTLHDCLSTVDGWSYKYNDIKLNISNDYFFPIYGKVNKVIITEIGDGTVQTSESLIDSNGYPIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSV7</accession>
    <name>M7NSV7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_00265</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872138.1">
        <property type="nucleotide sequence ID" value="XM_007873947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSV7"/>
    <dbReference type="STRING" id="1069680.M7NSV7"/>
    <dbReference type="GeneID" id="19893963"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00265"/>
    <dbReference type="eggNOG" id="KOG1134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002458_2_1_1"/>
    <dbReference type="OMA" id="FVQFNHQ"/>
    <dbReference type="OrthoDB" id="1076608at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF20">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="508"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="554"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="621"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="667"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="700"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="17"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="198"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="8">
        <location>
            <begin position="413"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="9">
        <location>
            <begin position="776"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR11843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="852" mass="97810" checksum="14170EDE4B0B2FFB" modified="2013-05-29" version="1">MGETGGIHNSEGTSLPAFITSLSVNFVMFTIQVVAFFILRNFLHRVYEPRSVIKILPSDKKVRSPPRSFLKLFLLLYQTCPEHIIKKSGLDAYFFLRFLRMCILLFSFSLLIIWPILLPINSVDGIDKTYKGKPRGLDKFSFGNVSPKHINKYWAHLVLAYLFVCVTCYLIYYELKHFIEIRQAYLTSPQHRNTTSATTVLITTVPDEYLDVGKLKELFSIYPGGVKNVWINRDFSPLLEQIEKRDIIAQQLEEAETCLIRNALKCSKKKKNKEKEKKVLDSKNAQYLDSIESSKGLVYKYVSFKKRPKHRLPLFSWFISLPLIGKKVDTINWCISELKRLNPEILEQQKHPEKFKQMNSVFIQFNEQISAHLACQNILHHNALHMTPKYLHISPKDIIWDNLQLKWWDRLIRAIIVVICIASLVIFFAFPVAFVGSLSNVISLSKKFSWLEFLGNLSKSVTGLITGLLPSVLLAIIMASVPIIMRFAAELKGLPTQTDVELTVQNMYFSFLVVQVFLVVTISSGITAVIASIINNPQNTPKLLAQNLPRASNFFFSYILLQGLSIASGELLQIITLILYYSFGKLMDNTPRKLWSRFTTLRVLEWGTTFPRFTNLSVIGITYSIIAPLIMVFVIIAFMLFYVVYLYNFLYVFDFPVDTGGLAFPRSLYQMMTGIYLLEACLTGLFFLARDDQNHFATKVQGILMIILIIFTVFYQILLQKSFDPLIKFLPLTSQNQNNNRNYIHYESSMQDMTSEGSKSPSHSADFNINCENLSIQERESIIFSSFQHKALQIKTPVIWLPQDELGIAKDEIERMPNEVLVSMEYAKIDNKGKLTFQSNPPDWDPYSSLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M7NT13</accession>
    <name>M7NT13_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_01507</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873446.1">
        <property type="nucleotide sequence ID" value="XM_007875255.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NT13"/>
    <dbReference type="GeneID" id="19895202"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01507"/>
    <dbReference type="eggNOG" id="KOG1246">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000991_0_0_1"/>
    <dbReference type="OMA" id="GFDQVCK"/>
    <dbReference type="OrthoDB" id="1678912at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034647">
        <property type="term" value="F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15518">
        <property type="entry name" value="PHD_Ecm5p_Lid2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013637">
        <property type="entry name" value="Lys_sp_deMease-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004198">
        <property type="entry name" value="Znf_C5HC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF33">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08429">
        <property type="entry name" value="PLU-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02928">
        <property type="entry name" value="zf-C5HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="13">
        <location>
            <begin position="50"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="ARID" evidence="12">
        <location>
            <begin position="115"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="326"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="14">
        <location>
            <begin position="464"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="1167"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="249"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="670"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR10236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1580" mass="182480" checksum="A2689058BEAF68D9" modified="2013-05-29" version="1">MTPNTSKLDQNPSCLYRKVKMEPIDLSTVEMNYQGPEKPRYPRPMGLHVAPTFFPTEEEFKKPLKYIESISEEGKKYGIIKIVPPKSWKPTFSIDSETFLFRTRKQVLNSMEGGFRANVSYLDKLFKFHKQQGSPIKVLPTIDKQPIDLYRLKRAVESRGGYHKAYERRRWEEIGREFGYTNDGRHFSNAVTSLKTIYQKYILPYDIYSEKIRNASKGYHNQKKEQNEKTSPASSNNFPLSEVYKNDLSNNLNNKLKNTKESHINIKNEEIHEDNKILSNSVNREKNESRSSRYIRKDLNGITKNNERLPNNGLVEASFANKDKIGDVCEGCHKGLDKSSMLLCHGCGVRYHIQCLEYPLTQIPKREWYCDACFLGTSDFGFEDGSTYSLKQFQEKANSFKKKYFSKKQFNKKQNSPSEADVEEEFWKLVGNVNITTEVEYGADIHSTTHGSGFPTLEKNPLDSYSSDPWNLNILPLSPDSLLRHIKTNISGMTTPWLYVGMCFSAFCWHNEDHYTYSINYQHLGETKTWYGIPSSDADLFEQIMRNTIPELFEQQPDLLFQLVTMISPAKLVDEGVRVYAVDQHANQFVVTFPQAYHAGFNHGFNFNEAVNFAIPNWMNEGYSLESVKRYKEFRKIPVFSHDELLLTISFHENGIKTSMWLNDIINEMKDRELKSRKFLREEITNLTEELDETDIHEDQYQCRICKSYTYLSQIKCKCTLEIVCADHYLELCACEKNTRILRLRYSDEHLNEIAGKISERSNLPVIWTKKFYKAMSENERPSLKLMRSLLSEVEKIQYPIEEVSSLRSFVAKVNEWVENANNFITRKQQNRRKNEKVWRKGKIAELGERDKIFRNPKYLESLLKEAESLPFDTPEIQMLREKADAIASFQNHARDVISQATVSSEQCLKIIELGKSFNVDIPEIEQFEQYYKQLLWIETVRDAENKYISLKEVNDLISEGKEIKIPENNPYFLKLKIRKENGEAWEAHAISLMEQETIPMDELVRLADQASSLSISQGILAKVNSIINKMHEVHNSVQNIQQRILNPDFWQRPTATELKKIMDIVNALPNPPEGVSFLQKEQQKLHEWIRRGKRLFGKANAPLETLGQHMEYVVKRNNLCLSLEDKPRALVVEPSSREQSPDPSTSLVINKADGYGISSGQIPHHDLFCLCRQPESGLMVECEICHEWYHGRCLKVSRKKLRDDDKWTCPICDYRVEIPRLSNRPKLEDMQQLLSDALFLPFIPSELDKLKEIVDTGVAFRNHIRSYIYSPLGLTSAEVPIMRFYLRKMEGSELLFAEETNFFKAKLHELVPIAPIPPQAIEISKSTRKPRPTKRQRELIALGLDPSSESLSEKFSPVTSKKSKTLNVSQPSNPKTNITPSPIPLICICRRPWIPNDSPKINCFDCGNWFHHSCVGLNEAISQTLNQYLCPNCCKRRNQPYLFHINNYNNDSTLSSSLNEIHSSNTYHYGRPLYHQDIKVNHSIGDYTSQSISSTNNISNIFEAFANQGLSDKTLLGNIRNDSDIENSVQSSQTDRELLYALVDLAQGIQGHQGTGHQEYSANLMDEDSNFADKYFNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NT31</accession>
    <name>M7NT31_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01153</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873067.1">
        <property type="nucleotide sequence ID" value="XM_007874876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NT31"/>
    <dbReference type="STRING" id="1069680.M7NT31"/>
    <dbReference type="GeneID" id="19894850"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01153"/>
    <dbReference type="eggNOG" id="KOG0131">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_21_2_1"/>
    <dbReference type="OMA" id="IVWELMI"/>
    <dbReference type="OrthoDB" id="10259687at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048026">
        <property type="term" value="P:positive regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12334">
        <property type="entry name" value="RRM1_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12335">
        <property type="entry name" value="RRM2_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000895">
        <property type="entry name" value="Hsh49p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000121">
        <property type="entry name" value="Splicing factor 3b subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034158">
        <property type="entry name" value="SF3B4_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034159">
        <property type="entry name" value="SF3B4_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052084">
        <property type="entry name" value="SF3B4_spliceosome_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030:SF3">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="13"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="101"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="287" mass="31587" checksum="D35F58ED15889E85" modified="2013-05-29" version="1">MATNKTDERNQEATIYVGNLDERTTDAILWELFLQCGPVVNVHLPKDRVSQTHQGFGFCEFLTIEDADYACRIMNQIKLYGKPIRVNKASADKKNTIEIGAELFVGNLDPLVNEKILYDTFSIFGMLVAPPKIARDDNGQSKCFGFISFDSFEAADAAIEGMNNQFLMNKSITVSYAFKKDGKGERHGDQAERLLASQARKNNVNLQSTGIPALPSGFTGQVPIGYPGQIPQNPAGFSQPPMGYLYQNYPGTIPQGYVQQPPATGVLPMMNSYPVIPPPPPLSNFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTP2</accession>
    <name>M7NTP2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec39 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01189</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873105.1">
        <property type="nucleotide sequence ID" value="XM_007874914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTP2"/>
    <dbReference type="GeneID" id="19894886"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01189"/>
    <dbReference type="eggNOG" id="ENOG502RS09">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_355693_0_0_1"/>
    <dbReference type="OMA" id="GMKRAYD"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013244">
        <property type="entry name" value="Sec39_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40787:SF3">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40787">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08314">
        <property type="entry name" value="Sec39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec39" evidence="5">
        <location>
            <begin position="12"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="789" mass="91455" checksum="A96EE42195AA0FD7" modified="2013-05-29" version="1">MLTDVSIPWLLYIAVQYASAPSLQTLSELILKFPYIFSKRVILSILNFVPECIDPDEYLSLIFDEKYEGEDDMDSSQISKTQNINNAALSQKLKKLHIYQDETKTNNCISDEELYAWFISRALQIEEETGLISFSRKLVLTSKYPIPPKVQEWGRGIVSTLESVINRQYNNPLLEFNVPTLREFETLNHKEVIDILLQHLENEEILEEIKSSIIPYISYCQKSSKTNIWDSLWSWLLNFSFKQKNLNLIKLISFNNVISSEKYSEFSKYAIASCYCLQSTEEENIHSMKIILQNLKQNLNIETNSNTSVLNDIKISSLNVFTPENIQDYSELITPNSDSLSLLEIMIKTVLIINSTKEICKITLSEAVCYRNKDKKSQISLLHKMIPQNPHFLSKLNDSEWIKLRNNIKWLHDVSLIYKNIPEIEYESFLLYNILRTTKFNLAENIYIKRNKGNMPLKDVMVEKICIEIFLEFFDSSSNGNITKGNMKNAYNLLQTIKQYYNSEQLESFSYLVKVTNTLYHYSHKFKPVQIRLHNNPFEILEDFLSSNPGIYKSIDEVMEICNDLLLSTNKNYLYQKEIQAKILCIIAETALSQNEFDFAYDICINHLFSLFEAVDIKTREALSNIIWKSCLQISKNYETEESLENIKKKMFLLSKVINICPKEYLVEVLNVWKRFEKEQLSIRSKKLSEFNDNLSVNPNTANSLRISKLLFSSASKAARALGTTLSSTSFPFNKQKILHIEKKVKKNLVSTNQELRSSNNKLDNLADVVTQKFTSGLGWVLGISDNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTS7</accession>
    <name>M7NTS7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01375</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873307.1">
        <property type="nucleotide sequence ID" value="XM_007875116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTS7"/>
    <dbReference type="STRING" id="1069680.M7NTS7"/>
    <dbReference type="GeneID" id="19895072"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01375"/>
    <dbReference type="eggNOG" id="KOG4561">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MPVYYSH"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF0">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="65"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="221" mass="25577" checksum="D0C66F7B741696D2" modified="2013-05-29" version="1">MSIFPSPPTSIETWISPYLDSLNLYTLSKHFHVVLGASLFYQFLFIISPFISKKLSRSYLTLNKSTRIKWDVHFVSMIQSILISCLILGCYQDDELKQDRLFGYNAYKGDIYSLACGYFLWDTITSFRYISLFGIAICLHGTAALSVFLFSYKPFLMYYGLAFLAFEFSTPFLNIHWFFNKTRMIGGICQLINGIILLLVFFLVRIVWGLYAAFNLTYISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUP0</accession>
    <name>M7NUP0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 14">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="10 14">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PNEG_00953</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10 14">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10 14">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 14">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="10 14"/>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872866.1">
        <property type="nucleotide sequence ID" value="XM_007874675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUP0"/>
    <dbReference type="STRING" id="1069680.M7NUP0"/>
    <dbReference type="GeneID" id="19894651"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00953"/>
    <dbReference type="eggNOG" id="KOG2653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024540_4_2_1"/>
    <dbReference type="OMA" id="CVTHVGP"/>
    <dbReference type="OrthoDB" id="434986at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.320:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000007">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006765">
        <property type="entry name" value="PRK09287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="5 10 14" id="KW-0521">NADP</keyword>
    <keyword evidence="6 10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 10 14" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="15">
        <location>
            <begin position="185"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="39"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="135"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="192"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMR10806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="494" mass="55091" checksum="C2F99AEF4E6C115C" modified="2013-05-29" version="1">MNSKGLKNIADFGLIGLAVMGQNLVLNSADKGFIVAVFNRTVSKVDCFLEKEAMGKSILGAHSIEEFCSLLKKPRRIMLLVKAGSPVDEFIELLLPYLEKGDIIIDCGNSYFIDTNNRYESLKSKGILFVGAGISGGEDGARYGPSIMPGGNFDAWEYIKDIFQSISAKSNGKPCCDWIGESGSGHFVKMVHNGIEYGDMQLICEAYDLMKRGLSMSNREIGDVFSEWNKGFLNSFLIEITCDIFYYTDENGEYVIDKILDSAGQKGTGKWSAMSALDLGVPTTLIGEAVFSRCLSNIREERIKASKRFQNMSFKYTGDKKEFISHLEQALYASKIISYTQGFMLLKQASIKYGWKLNNSSISHMWQGGCIIRSIFLNEISKVYLASPDLENLLFEPFFHNAIITAEPSWRKIVSTAIEIGIPTPAFSTALSFFDGYRSQWLPSNLIQAQRDYFGAHTFQFLPEVITDKFKDVKNVHIDWTGHGGHVASSVYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUT7</accession>
    <name>M7NUT7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01012</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10866.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613309.1">
        <property type="nucleotide sequence ID" value="XM_019757730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUT7"/>
    <dbReference type="STRING" id="1069680.M7NUT7"/>
    <dbReference type="GeneID" id="19894710"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01012"/>
    <dbReference type="eggNOG" id="KOG2861">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141771_0_0_1"/>
    <dbReference type="OMA" id="IFHFYEK"/>
    <dbReference type="OrthoDB" id="242766at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF1">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="3">
        <location>
            <begin position="111"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10866.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="348" mass="40902" checksum="D742167B5A4F10EB" modified="2016-03-16" version="2">MIQSVFLQRYRISYIKGFSKIHNKTFVFILHEFLRYFQNLSSKHISQHFELRPNLAKKVNKSLSEVIAFSTAESYDFLHLKSILPENAIYLPRNRVFYIPKSSFDIDIRDIFIFSSGSFVIWGSSIEKCEYFLNTVIRGKFSGIEISPYHKYKKEVFYYEKNKNKDLITIGNDFDHSKISDFESIASDNIIMAQLSFSESMARSSKLSVLEDELENYLNQLKTIPDSLVLGKVPLSRSEIIKKTGTLLRFRSHFNLYPENFLDLPEFYWENVKLEECYLKANEALDMNLRLDIVNTKLNYATELQFTLRQVLSENTTHRLELIIIWLIFIETVFAVGGYFDTIHKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUV5</accession>
    <name>M7NUV5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00686</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872584.1">
        <property type="nucleotide sequence ID" value="XM_007874393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUV5"/>
    <dbReference type="STRING" id="1069680.M7NUV5"/>
    <dbReference type="GeneID" id="19894384"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00686"/>
    <dbReference type="eggNOG" id="KOG1083">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_664145_0_0_1"/>
    <dbReference type="OrthoDB" id="422362at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17907">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00570">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AWS" evidence="9">
        <location>
            <begin position="227"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="281"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="48243" checksum="031605343B1D011C" modified="2013-05-29" version="1">MRYLRERKVFSGSDCVSKEDKSLLTKNMNSQENENKSAQKVYITQSRMNMSDKNFSVSSERLRGLRKKKYCSEKNCHNRERVKYVDILRDFFTRSQIPTEKKGSLILFEAVEAARCSLNRDDMEKKNKNAASGDKDRNKSFERKGKTYLTQGLYAFSFNYTRESDSNNLKKKEIFPLPIHYGITLIDHLRDFKLPWNLFATSKKSYRPGGWRYIKQNIYGKEKFKKIFRPKCNCKQGSDCGDGCLNRELFYECDDATCALDNSQECSNRAFQDYTKKRMEGRLSSLNTEIIWTGKCGFGLRSLRDFEANSLIVEYCGEVIEKNELFRRMNSIYKDARNYYFLNFESGLVLDAGIKGNEARFINHSCKPNCKIEKWYVKGIPRIGVFVGEAGLFAGEDITYDYNFRKAKAHCIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7NV24</accession>
    <name>M7NV24_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00579</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR10976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872474.1">
        <property type="nucleotide sequence ID" value="XM_007874283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NV24"/>
    <dbReference type="STRING" id="1069680.M7NV24"/>
    <dbReference type="GeneID" id="19894277"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00579"/>
    <dbReference type="eggNOG" id="ENOG502S99K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090404_1_0_1"/>
    <dbReference type="OrthoDB" id="73901at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF27">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN CTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="157" mass="18958" checksum="4F8B54D43D779689" modified="2013-05-29" version="1">MLMDCGSMTFNIDMKTPLFIKEWVPKNNIQYFFTLIFIIIISIFYRAISTYKLQWKCKQKIVCMNCSKLKEIDIYYRPEIMRSENNKYLQTMPSFRLSVDFYWAFLQFVTYFFSYLLMILVMSMNIGYFFAVLVGIFIGEVVFSRYNYAFIRPCEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M7NV84</accession>
    <name>M7NV84_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872538.1">
        <property type="nucleotide sequence ID" value="XM_007874347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NV84"/>
    <dbReference type="STRING" id="1069680.M7NV84"/>
    <dbReference type="GeneID" id="19894336"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00638"/>
    <dbReference type="eggNOG" id="ENOG502QSBU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_839695_0_0_1"/>
    <dbReference type="OMA" id="CFERSNT"/>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="331" mass="36689" checksum="878C1F8FDA0AFE40" modified="2013-05-29" version="1">MTNPSTQQKELNYSCDHNINQFCFERSNTNTTSNKEFTLSDILERWTGSEETLRTIMIAKAEEDRLKQEIVRLNIKKVENEILINAVRSGVQLNAIPIIFSGQQNNSILTLSQNNPLTSTSSIQYQLQNSGLCEASVPGCCPGTQGSDSISNQSILHPFQTNVSNISLESFSTQSSLQKNAKSPFMIPKNTTESTSNQSSVLNPNSSPLPSLFFHYWIPPGESINSMSTTNNEGTELAVSSQSNILGSHEKEILSFSPSKKKRLSQLQQPLPPSFGNSILPPLSRRSPRRHSRHLSETSISQSNFFDIQGNKRAISPISNEINLSKSKNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVJ4</accession>
    <name>M7NVJ4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Lariat debranching enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_03603</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lariat debranching enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872739.1">
        <property type="nucleotide sequence ID" value="XM_007874548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVJ4"/>
    <dbReference type="STRING" id="1069680.M7NVJ4"/>
    <dbReference type="GeneID" id="19897290"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03603"/>
    <dbReference type="eggNOG" id="KOG2863">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005893_1_0_1"/>
    <dbReference type="OMA" id="KWWFSAH"/>
    <dbReference type="OrthoDB" id="407609at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008419">
        <property type="term" value="F:RNA lariat debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032197">
        <property type="term" value="P:retrotransposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016074">
        <property type="term" value="P:sno(s)RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00844">
        <property type="entry name" value="MPP_Dbr1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000035">
        <property type="entry name" value="Lariat debranching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007708">
        <property type="entry name" value="DBR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041816">
        <property type="entry name" value="Dbr1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849:SF0">
        <property type="entry name" value="LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849">
        <property type="entry name" value="RNA LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05011">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01124">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lariat debranching enzyme C-terminal" evidence="13">
        <location>
            <begin position="267"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR11166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="412" mass="47715" checksum="907DEE9E7D9C4B0F" modified="2013-05-29" version="1">MKIAIEGCCHSELDAIYRELKRQEEKTQSQVDVLLIAGDFQAVRNEADLACLSVPEKYRKLGDFSSYYSGEKKAPVLTIFVGGNHEASNYLWELYYGGWVCPNIYYMGAANIINIGGLRVGGISGIYKEKNYTKGHFEKVPYNMESLKSVYHVREFEVCKLLNTGRTKPIDIFLSHDWPRGIEKHGDLKRLLSIKPYFFNDIQNNCLGSAANERLMNELQPAYWFSAHLHVKFEAIKIHNVYENWKENMVEMVKENPDEIDLNDEDDKVITKIEASHKITRFLALDKCLPGRHFLEILDIPTPHEVNEKPILSYDVDWLAICRVFHPYFSIEYQQPSLPWDNAYLAREIEKEKEWVYDHIVQLHGLEIPQHFEHTAPVVGNAFSAYPPPLYNNPQTEAFCKMLGIDNKIYQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVK2</accession>
    <name>M7NVK2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00346</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872219.1">
        <property type="nucleotide sequence ID" value="XM_007874028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVK2"/>
    <dbReference type="STRING" id="1069680.M7NVK2"/>
    <dbReference type="GeneID" id="19894044"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00346"/>
    <dbReference type="eggNOG" id="KOG0153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027112_0_0_1"/>
    <dbReference type="OMA" id="CPLRVQW"/>
    <dbReference type="OrthoDB" id="10259600at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12265">
        <property type="entry name" value="RRM_SLT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000396">
        <property type="entry name" value="Putative Pre-mRNA-splicing factor slt11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034356">
        <property type="entry name" value="Slt11_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048995">
        <property type="entry name" value="STL11/RBM22-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF6">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21369">
        <property type="entry name" value="STL11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="200"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="343" mass="38718" checksum="C93712C7AC2C8B59" modified="2013-05-29" version="1">MPPKLDINKSGWESAEFPAICESCLGPNPYVRMTKREYGKECKICTRPFTVFSWHPGKESRYKKTEICLTCSRIKNCCQNCLLDLQFGLPIQVRDAALKLVNQGPQSDINREYYAQNNEGKWKDGNTPCEFGKVDSAARELLKKLARSEPYYKKQIHMAKNPELSNISNHSTDSSAPVFGRSISHITSNQLVPPQDKKITSLFIIGIEDDLPEHAIRVYFEKYGPIKSLVCSHRSRCAFVNFTTRVAAETAAKACRNGDILINGCPLKVQWGRPRPLGGYNQEQQNAKMSRFVMSQSQFATQNPGEESHATSEIKKPEDTVLELPPGQDGDIAYQSMHPYYQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWZ7</accession>
    <name>M7NWZ7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_00122</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871981.1">
        <property type="nucleotide sequence ID" value="XM_007873790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWZ7"/>
    <dbReference type="STRING" id="1069680.M7NWZ7"/>
    <dbReference type="GeneID" id="19893820"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00122"/>
    <dbReference type="eggNOG" id="KOG2575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008110_2_1_1"/>
    <dbReference type="OMA" id="RVYMRAT"/>
    <dbReference type="OrthoDB" id="5589195at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042281">
        <property type="term" value="F:dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF1">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="340"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR11686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="478" mass="56637" checksum="681CFD8EE638A6CD" modified="2013-05-29" version="1">MDHKKTLKKYDTQTNIKKESNDVWEPICWMIYVVKWRGNSGGKYGDFEAQRHWMEITLHLPIKEWYFYDLQWWGLDYPPLSAYLSYIYGKIGNLIEPSWFALDTSRGLQIQDLKFYMRMTVIVSDFIIYFPAVIRFSRYWKRLEKGNALNTYSSIALILLQPALILIDHGHFQYNNVMLGLVLLSLCYFINDRYILGSIFFVCSICFKQMSLYYSPLIFFYLLGLCTKPQFNIRRFIYISITTVSTFAIIFFPFYIYSGYNGVLQCIYRIFPFERGLWEDKVANVWCVLNIFINSIATLISILPPCLIIFLKPRVCLLPWGLTCSAFGFFLFSYQVHEKSILLPLMPATILLLIPNKNMKAWIGWINIIATFSMWPLLKKDGLELQYAVLQIYWLWLGGFMFFPLNKFEKFIHKTSYAFLIIIHILDAFITPPLHLPDLWILLNMKLSFICFGIFWLWSFWKLWLKSGICMSIKTKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M7NX86</accession>
    <name>M7NX86_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872056.1">
        <property type="nucleotide sequence ID" value="XM_007873865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NX86"/>
    <dbReference type="STRING" id="1069680.M7NX86"/>
    <dbReference type="GeneID" id="19893891"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00193"/>
    <dbReference type="eggNOG" id="ENOG502SCRM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_877505_0_0_1"/>
    <dbReference type="OrthoDB" id="2555634at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018800">
        <property type="entry name" value="PRCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621:SF2">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10253">
        <property type="entry name" value="PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="317" mass="36292" checksum="52D729B386EA5FE8" modified="2013-05-29" version="1">MAGLVNYSDSEDTEECSEEDARKSVKRKELDGVSDSSFFPILTKENILKLPKIDKEYELEDTKKSLFLNNDVMGEHVSLSSLLPAPKNDLKMARSSRNNGTKKLNIKIENKHNSVIKNTISKDGNMKNDSTQSDIPLFSLDIEKSNVNEYEQTMLNSSSYIPMLVKKQTLLDKKRNDSIEDVKLSEKKQQNVHCSEIYRVDKDIDVSEYTYSLTEEKNQISRKEKDVESMRIYGKRRSEQGPVKFLEVNAEEEYNTNEIMKRKGILVEAPQPIRAIGAGRHQITTLLNSAISQREVFEETFAANKESKRQSGKKYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7P2N3</accession>
    <name>M7P2N3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_03582</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875676.1">
        <property type="nucleotide sequence ID" value="XM_007877485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P2N3"/>
    <dbReference type="STRING" id="1069680.M7P2N3"/>
    <dbReference type="GeneID" id="19897269"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03582"/>
    <dbReference type="eggNOG" id="KOG1061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006320_4_4_1"/>
    <dbReference type="OMA" id="FIQRPTR"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="17"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="608" mass="70215" checksum="BDF8BCAA4251E8DD" modified="2013-05-29" version="1">MNRDKKLFIKEKVQELRLELSDEKKDKKHTRKKMVLKKIIANMTMSNDMSSLFPDIIQCMDIPVLEIKKMCFLFLINYSKLKPNMALQALPILIKDLNDKNPLIRSLALRTMSYINIKEFTNSIIIPLYQLLSDSDPYVRKTAAICVAKLYCINKSIVEENNLINELKKKLHDTNSIVVSSSLLSLSQISEHSDSIKLDISTSYANKLANMLDGCAEWNQIYILEALINYIPQEENDAEILAEKITPRLQHSNTCIIFTTIKIILYLMNYMHNENTIKVLSRKLFSSLIILLSKDYEIEYITLKNVQIILQKIPNIFENNIDIFFCKYNDPLYIKLAKLEIITKIANKENIDSIISELKDYTAEIDKNFVKKSIQSVGILAIKFESITERCINILLALIETKIPYIIQESILVIKNIFRKYPNKYESIISIICSNLNNFNDPEAKAAVIWIIGQYSNMIENSHQLLNNFFSTFSDETLEVQFALLTASAKLYIQQSHDNQNFILSLLKKVIEDTGNPDLRDRAYMYWKLLLGDNYTAKKIIMENIPSITLPLQNFDQKTLDELCLNLGSLSNIYYKTPSQLIAGSKVKEIQSSKVLRNRFNLKKSLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7P426</accession>
    <name>M7P426_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_03097</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="1"/>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875152.1">
        <property type="nucleotide sequence ID" value="XM_007876961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P426"/>
    <dbReference type="STRING" id="1069680.M7P426"/>
    <dbReference type="GeneID" id="19896784"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03097"/>
    <dbReference type="eggNOG" id="KOG0433">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_7_2_1"/>
    <dbReference type="OMA" id="PVYWGTE"/>
    <dbReference type="OrthoDB" id="10264412at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07960">
        <property type="entry name" value="Anticodon_Ia_Ile_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.830">
        <property type="entry name" value="Ile-tRNA synthetase CP2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033708">
        <property type="entry name" value="Anticodon_Ile_BEm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050081">
        <property type="entry name" value="Ile-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="8">
        <location>
            <begin position="1"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="9">
        <location>
            <begin position="624"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="874" mass="102244" checksum="CC3570C6268C3AAE" modified="2013-05-29" version="1">MKGRRVSYIPGWDCHGLPIELKVLEDNEQLSFYKSPMMIRKKAREYVLETIKHQKESFKSFGIMADWEKSYHTLDVSYIIQQLDIFKKMVEKDLIYRRYKPVYWSPSSKTALADAELIYKNDHISQAIFVRFPLINLGKLSAIINIKNKKPLYVLIWTTTPWTLPANKAILIDKDMEYTIVNTTQYGNLIVSRNRVPHLLKFINISETSLHFFGEALLGATYYNPLEENFKEMPFFHTKYITSDSGTGLVHAAPGHGMEDYEVCIQHNIPIFSPVDDHGCFTKEALNGKLEFLFVLEHGNKKVIELLENQKMLVSLEKYIHKYPYDWRTKKPVIQRATAQWFVDIEKIKYQTIKALKNVKMIPENGRERLISFLRSRSEWCISRQRAWGVPIPVLYSLENEKPLLTVKNINHIINMVKKYGMDTWWQDSESDIWVAPEYKKDGIRYKKGMETMDVWFDSGVSWNVIFNNRDYDNLNSEKDKPLIDLVLEGSDQHRGWFQSLLLTFVASQNDHSNIAPYGTVITHGHVLDQYNQKMSKSIGNVINPENIIFGEKDIKKGPAYGVDVLRLWAVGNNFTNDINISSLVLKNVAEIQRKFRATLRFLLGNLHDWNGDKVEYKDLKKIDQYALAQTYEFNRKTIELYDKFLFFQVVHAITNYTNNQLSSFYFDIIKDRLYADHRTSKSRTSCQTVLFHIFRNYISIISPIAPSLALEAWKFSRKEIIGEIETPFHSGWYKCEEEWLNLELQKEFQNIKTIRSASNLILEKARKNKYIRSSLECEIIIKAPLKTQAFNFLKKIEHELSQILIVSDISVISMDSELLNQKWDDYQEITLFGSTCHLIAKLSEKKKCLRCWMYTATMNADICHRCKEVMLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M7P4S7</accession>
    <name>M7P4S7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major surface glycoprotein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874631.1">
        <property type="nucleotide sequence ID" value="XM_007876440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P4S7"/>
    <dbReference type="STRING" id="1069680.M7P4S7"/>
    <dbReference type="GeneID" id="19896304"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02613"/>
    <dbReference type="eggNOG" id="KOG3544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010455_0_0_1"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003330">
        <property type="entry name" value="MSG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02349">
        <property type="entry name" value="MSG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="675"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="629"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="682"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="697"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="920" mass="106983" checksum="C8956DA31F333150" modified="2013-05-29" version="1">MTAQLVKRQAAGQAEGNDEIKEEQVLGLIVKKEYNNDAKCKKKLEEYCAELKKINGKLENVDAKVKGLFEKESKDLKKELLEAFKNIKDENCRKYEDKCIFLEEADPINLKENCVKLINKCSKRKRQDFVYGIFYNTFVFKSSVEDVCTRLDRILNENELKEKCQEYFENCYFYKSNCRSTKYFDPLEIKATLDRIILEKIYEKAEVKEIITGKLQEKSLENTILLWSRENNSKNLQEICKNILNDCNFLYMNYNLKALCKEASKNIDSRCKELVKVETRCTNLKLELYIKGFSTEFEKNKDSKYFSWEQVPKLPSKEDCIKLESECFYLENVCTNKIDKACENLRIAYYRKGQNLAFNKLIRNQFIRLMVKNCIKFKEDKRYLLKCLQPTKLCYEFLEDIIDQSKEFEALLDSKKEFPKEILNTNCGYLETRKKFKKIFLEKKDNSLKTRENCIKAVKEECERLSRRKKNPFVTFCALPEETCNFIVKEVIDECYNLAYNMNDRNIINKIEKTNKALTKEICMFWDPYCHQYIENCPEILKQENINTKRAHCLKLQRYCTPLWENLRLEGELIHELKSSLINDTICKETLEKYYTKWKSEKNQTFDNASEDKNGSSEHLRRNVCKKLIEKVKRKCSTLKNELDKEKDELKEKNEYEKVKKEAENFMKVTNLLLSKPKKNENGQSATLSVQNNSVLAPVAPSTAPPTAAESASSQGGTEHTTEQRLILRRFVDEGVSKTETNAFDLMTRALKLYLGMKEDCKTLQVNCGFRENCLNFGTVCEDIDKLCNVKPLEVIPHHTLILTTISTTTRTATMPNNSDIDDNVTTSIKEAATEQCTLIRTINTSVIDTSLHTSTMTSTSAVTSTVTLTSMQECKPTRCTTDSSRKTKMRGKLISGQGMKMRVPKMIKIMLGVIVMRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7P4X3</accession>
    <name>M7P4X3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Adenylyl cyclase-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02673</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The N-terminal domain binds to adenylyl cyclase, thereby enabling adenylyl cyclase to be activated by upstream regulatory signals, such as Ras. The C-terminal domain is required for normal cellular morphology and growth control.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874696.1">
        <property type="nucleotide sequence ID" value="XM_007876505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P4X3"/>
    <dbReference type="STRING" id="1069680.M7P4X3"/>
    <dbReference type="GeneID" id="19896364"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02673"/>
    <dbReference type="eggNOG" id="KOG2675">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015780_1_0_1"/>
    <dbReference type="OMA" id="PISDHIH"/>
    <dbReference type="OrthoDB" id="77251at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008179">
        <property type="term" value="F:adenylate cyclase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010619">
        <property type="term" value="P:adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019933">
        <property type="term" value="P:cAMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030308">
        <property type="term" value="P:negative regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031138">
        <property type="term" value="P:negative regulation of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030836">
        <property type="term" value="P:positive regulation of actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090141">
        <property type="term" value="P:positive regulation of mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046579">
        <property type="term" value="P:positive regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.330:FF:000001">
        <property type="entry name" value="Adenylyl cyclase-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.330">
        <property type="entry name" value="Adenylate cyclase-associated CAP, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001837">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013912">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053950">
        <property type="entry name" value="CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036222">
        <property type="entry name" value="CAP_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652:SF0">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08603">
        <property type="entry name" value="CAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21938">
        <property type="entry name" value="CAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101278">
        <property type="entry name" value="N-terminal domain of adenylylcyclase associated protein, CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="5">
        <location>
            <begin position="317"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="280"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00072052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="474" mass="54199" checksum="6F0A3A5E1FE0327A" modified="2013-05-29" version="1">MISNIYATREKNIEANLHFLVKRFESVAERLEKLSGLSVESLEVSKDEEKKPETVFKSFFFSIMKEYQCFSEKLDKEVMEQAQYVLEAFEMLGEFIEKGSCMEKPDFSSSEFQTLIQPLQDKIDKVINIRNKNRGSEMFNHLSMVSEGIVALGWITVEPTPVLYIGDMKDSAQFYANRILKEKGSLDTKWVYSFINLLTELQSYVKLYYNAGFLWNSNKTNLENDKKIHNSTDIEDKTEADAVLQPRISESRTKRSNNIESVFSELNMGESITEKLRKVNKNQTTHKSPSHSAQSSAPSDYRLSQVSTTEEKKTKLPCKKELAGSRWNIENFEDNHNIVINQLETNQTIYIFNCKRCTISLKGKANTVYIDQSFNCGLIIDTLISGIESTRSASLEIQISGYTPTITLDQCDNSQIYLSPKCLSTEIITSKFSSINVHVLEEKNGDYIEHHIPEMLKSTIINGKLVTNFVEHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7P4Y5</accession>
    <name>M7P4Y5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02687</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874711.1">
        <property type="nucleotide sequence ID" value="XM_007876520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P4Y5"/>
    <dbReference type="STRING" id="1069680.M7P4Y5"/>
    <dbReference type="GeneID" id="19896378"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02687"/>
    <dbReference type="eggNOG" id="KOG0181">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_4_1_1"/>
    <dbReference type="OMA" id="ATCIGKD"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03750">
        <property type="entry name" value="proteasome_alpha_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="4">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="251" mass="27611" checksum="8AFB93A70B560229" modified="2013-05-29" version="1">MVDRYSFSLTTFSPNGKLVQIEYALAAVNQGVTSIGIKAKNGVVLVTEKKSQSSLVEQDTIDKVSCITPSIGMVYSGIGPDFRVLVDKARKLAHSAYKLIYREYPPTRILVQDLAKVMQDATQSGGIRPFGVSILVAGWDKHNGPSLYQIDPSGTYFPWKATAIGKSAISAKTFLEKRYNDQLELEDAIHIALLTLKEGFEGELSEDTIEIGAVGPSVTYNLGTEDTNEPLCPQFRKLTKIEILDYLEQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7P551</accession>
    <name>M7P551_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874805.1">
        <property type="nucleotide sequence ID" value="XM_007876614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P551"/>
    <dbReference type="STRING" id="1069680.M7P551"/>
    <dbReference type="GeneID" id="19896464"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02775"/>
    <dbReference type="eggNOG" id="KOG1659">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045277_9_0_1"/>
    <dbReference type="OMA" id="YANIKTH"/>
    <dbReference type="OrthoDB" id="653904at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22906">
        <property type="entry name" value="HFD_DRAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF5">
        <property type="entry name" value="DR1-ASSOCIATED COREPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="14"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="132" mass="14851" checksum="4E740EB846C38043" modified="2013-05-29" version="1">MSSSQPNKPSYKPKFPIARIKKIMQADEEVGKVAQITPVVVSKALELFMQSIVDETVKQARIKQAKKVTITHMKNAIQSADQFDFLIDIIDKYTNTGSFEKDTGHSSEKIQENKNDITFLESNSSSKKKNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7P5G2</accession>
    <name>M7P5G2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinetochore protein SPC25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_02463</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Chromosome</location>
            <location evidence="9">Centromere</location>
            <location evidence="9">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the SPC25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874472.1">
        <property type="nucleotide sequence ID" value="XM_007876281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P5G2"/>
    <dbReference type="STRING" id="1069680.M7P5G2"/>
    <dbReference type="GeneID" id="19896156"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02463"/>
    <dbReference type="eggNOG" id="KOG4657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065188_0_0_1"/>
    <dbReference type="OMA" id="HEDQRMK"/>
    <dbReference type="OrthoDB" id="4056921at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23784">
        <property type="entry name" value="RWD_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.457.50:FF:000001">
        <property type="entry name" value="Probable kinetochore protein spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.50">
        <property type="entry name" value="Chromosome segregation protein Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045143">
        <property type="entry name" value="Spc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013255">
        <property type="entry name" value="Spc25_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281:SF0">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08234">
        <property type="entry name" value="Spindle_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 9" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation protein Spc25 C-terminal" evidence="11">
        <location>
            <begin position="173"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="67"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR09120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="248" mass="29711" checksum="8E057623F1867900" modified="2013-05-29" version="1">MSSSESVFFPANCESSLLSTLPSINLSFDEMKHKMAQFTLKFDKFIMNMREKKLEERNRYMKSIGEDREIQKNLQKQINDCKEIEKNSIEAVEKEKQEVIEAERSIAEFKEKKAMMTEKREYLLQQIQEISQAIQKKREFRTNMRHMFIKQAAKNQPELRFWEEHLAMKIKGVKDDFLKIIFTHIDENDWMKEFYFIINLSKREYEVTECSPALATVHEIVSKLNSSRDFFEFLKNMRKAFKKSIQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6X9</accession>
    <name>M7P6X9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-rRNA-processing protein PNO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-rRNA-processing protein pno1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_02228</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874212.1">
        <property type="nucleotide sequence ID" value="XM_007876021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P6X9"/>
    <dbReference type="STRING" id="1069680.M7P6X9"/>
    <dbReference type="GeneID" id="19895921"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02228"/>
    <dbReference type="eggNOG" id="KOG3273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064992_2_0_1"/>
    <dbReference type="OMA" id="TPLRNNW"/>
    <dbReference type="OrthoDB" id="1932641at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042255">
        <property type="term" value="P:ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22391">
        <property type="entry name" value="KH-I_PNO1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22392">
        <property type="entry name" value="KH-I_PNO1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000009">
        <property type="entry name" value="RNA-binding protein PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055212">
        <property type="entry name" value="KH-I_PNO1_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="9">
        <location>
            <begin position="139"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR09645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="234" mass="26580" checksum="9799BF4560145703" modified="2013-05-29" version="1">MQDLQQNQASNEELLINVDSVPLAFQGGDNERHLDEANQPHFSASTKKIKIFKQPEMISVRIPYHRIAPLKENWSKIYSPLVEHLKLQVRMNLKNKTIDLRTSIYTERPESLQKGSEFVKAFSMGFDVNDAIAMIRLDDIYIDTFEIKDVKTLQGQHLSRAIGRIVGKDGKTKFAIENATRTRLVIADTKIHILGAFLNINMARNSVVSLILGSPTGKVYTNLRNVSARLKNMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7P7F6</accession>
    <name>M7P7F6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL29m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">54S ribosomal protein L4, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01959</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873936.1">
        <property type="nucleotide sequence ID" value="XM_007875745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P7F6"/>
    <dbReference type="STRING" id="1069680.M7P7F6"/>
    <dbReference type="GeneID" id="19895653"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01959"/>
    <dbReference type="eggNOG" id="KOG3331">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063281_2_1_1"/>
    <dbReference type="OMA" id="KFVLWER"/>
    <dbReference type="OrthoDB" id="270763at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038340">
        <property type="entry name" value="MRP-L47_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010729">
        <property type="entry name" value="Ribosomal_uL29_mit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183:SF18">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183">
        <property type="entry name" value="RIBOSOMAL PROTEIN L47, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06984">
        <property type="entry name" value="MRP-L47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="161" mass="19396" checksum="23773A9BFA1BF970" modified="2013-05-29" version="1">MRNIISLKNFIYKRFTQSLSKVKPYQIKYQPNQSNSLEINPKHGLWDFFRDSEDKSLKKEVLSTPKNDMKHGRAWMASELRLKSFDDLHRLWYICLKERNIIATQRHERRRLRIFTGIEEAIKRDKQVRLTMARLKFVLNERIRAWNSAKKLAEKDGHPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7P7L0</accession>
    <name>M7P7L0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CDC20/Fizzy WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02021</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874001.1">
        <property type="nucleotide sequence ID" value="XM_007875810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P7L0"/>
    <dbReference type="STRING" id="1069680.M7P7L0"/>
    <dbReference type="GeneID" id="19895715"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02021"/>
    <dbReference type="eggNOG" id="KOG0305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014831_3_0_1"/>
    <dbReference type="OMA" id="RDDFYTT"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF5">
        <property type="entry name" value="MEIOSIS-SPECIFIC APC_C ACTIVATOR PROTEIN AMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="6">
        <location>
            <begin position="120"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="261"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="17"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="482" mass="53346" checksum="700AA54132DB01BD" modified="2013-05-29" version="1">MSSIQTTPSKIIKSLRSSPDRFIPTGHSVSTFRMRSPGPKKISTDNDNGSPRSSKVISETHESRIAEALGFDRSSNVFIYQKPPCLTRCKPCDDQLDLLNFSTSKAIPKRPVSMQPIKVLDAPNLRDDFYTTLLAWSSKGDLAVGLADNVYLWNNTDGTTQVPEDFSDQFVSSLAFSYHGDILAIGRVDGMVQFWSKGEYAPRLELAHAGDIGCMTWRPKHPLRSKSKNDLLVGAHNGKIYYYEIEWTNSSANARLLKIISNAHQEQICGLAWNIDGTQFATGGNDNFVCLFDALRLDKPKIVWQHFAAVKALAFCPWQKSLLATGGGSHDKRIRFYHTYTGALINMIDCGGQVTSLTWSPTYREICATFGYSFSDISHRIAVYAWPTLKLLVSIPAGHPELRAIYAVNTVAKNENGENVGGGTIVVAASDETVRFYKMWEDERGSIASGGGGRAVRWEGVFGSDIVELVEGIDREGNEKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7P7S6</accession>
    <name>M7P7S6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01675</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873637.1">
        <property type="nucleotide sequence ID" value="XM_007875446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P7S6"/>
    <dbReference type="STRING" id="1069680.M7P7S6"/>
    <dbReference type="GeneID" id="19895369"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01675"/>
    <dbReference type="eggNOG" id="ENOG502QT9Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_787826_0_0_1"/>
    <dbReference type="OrthoDB" id="5394557at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="352" mass="39111" checksum="7001B9599F300F57" modified="2013-05-29" version="1">MTFHSTCETLVSQNITPGFLSINKKMEIDNTLFKTRALDTIKFPYRSRSLPLKSSDSPRQRIDVACQRCRRRKIRCSGDQGRPDGKCTHCIKANYPCEFVSRIHPPIQISPILMSPSPQSPSTVESPQPYLNSVVQFPSALSPGLTSNMNHHDTSWSNNVSTVLTNKHVSNLPIYNQDLYGTSETLSGLSCTSYSRTTPSLMGLHSYLMANEPSIDLWTSENLYTQIHDSSSILETTTELATSDQYLTMPQSSGSSSEHPLSFDHQASQFWSSNPLSQFTWTLDCNKESFDSVPILSSSYDASSDSAWDSQSPITDLFPNNNIDGSTLDGMFCFIKDLSPTPVLQDDSSTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7P837</accession>
    <name>M7P837_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor spt8 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01794</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873762.1">
        <property type="nucleotide sequence ID" value="XM_007875571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P837"/>
    <dbReference type="STRING" id="1069680.M7P837"/>
    <dbReference type="GeneID" id="19895488"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01794"/>
    <dbReference type="eggNOG" id="ENOG502QS8F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010934_1_0_1"/>
    <dbReference type="OMA" id="WDRRQPN"/>
    <dbReference type="OrthoDB" id="10260946at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900237">
        <property type="term" value="P:positive regulation of induction of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057544">
        <property type="entry name" value="Beta-prop_SPT8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23798">
        <property type="entry name" value="Beta-prop_SPT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="5">
        <location>
            <begin position="83"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="215"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="508" mass="56732" checksum="27A6667B8010DB11" modified="2013-05-29" version="1">MINIDIDSEDDKIDDKDTLSSINGNGSSEFLQNQDLNYEDDEIDRFSENLISSESDSKCTSNKSLSTKKNHTDNSHAIQANSYDIIPTFTAPHSTSINIITATSCMRWIFTGGNDGYIRKFDFFSSINGKIPLTVAQRHPFVDSVVNAGVLLSYWENNDSQNSLTSISTNSYHKLSPVYCLAVNKQALWMLSGIDTGVINLQSVRHDEGRILATMKKHISPVSVLELSSCETKVLSGGWDKNVYEWDLNTGVVSRSYDNHTGQISTIAYRPIFPITITSTSNSIKNEPEIDLKSELNKTNNLLKDFSDSIFDNKRVKKKNISNSFKNINDYTNDSNLNNELIQNKNEFIVSGIDGSITIWDERQLKHIAKLGIPNGTPPWCMNACWSADGKYIYAGRRNGTVDEFSMYSALDKPLRSIKLPLNSGPVSAVHSMPNGKHLICASYDNIRIYDLNGSSKIPFLIIPGHYGGVISSIYIDNTYKYMLTASGNRGWDGNYTETLLGYEIECL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7P871</accession>
    <name>M7P871_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01826</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873797.1">
        <property type="nucleotide sequence ID" value="XM_007875606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P871"/>
    <dbReference type="STRING" id="1069680.M7P871"/>
    <dbReference type="MEROPS" id="M20.005"/>
    <dbReference type="GeneID" id="19895520"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01826"/>
    <dbReference type="eggNOG" id="KOG2276">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029469_3_0_1"/>
    <dbReference type="OMA" id="PMNAIPG"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF4">
        <property type="entry name" value="CARNOSINE DIPEPTIDASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="5">
        <location>
            <begin position="84"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="349" mass="38263" checksum="26A65D488F07ECAF" modified="2013-05-29" version="1">MYGRGATDDKGPLIGWLNAVEAFQKAGIEIPVNLVFCFEGMEESGSVGLYELIQEEADKYFADVDCICISDNYWLGTKKPCLSYGLRGIVCYIITVTGPPADLHSGIFGGITYEPMTDLIYLLSSLVKSDGTILIPGIMDKVKPLTSEEEALYEGISISTEDIEHSLGSKTLVYDNIKCTLMHRWRYPSLSIHGIEGAYSSSGIKTVIPSKVLGKVSIRLVPDMDYDEVSVLVKKHLESVFATLGSKNVLTIESNHGAKAWLSSVKHWNYQAASKAVEKIYGVTPDFTREGGSIPVVLTMESCLKKNVLLLPMGRGDDGPHSVNEKLNRSNYIQGIKLFGTYLCELAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M7P8I0</accession>
    <name>M7P8I0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01449</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873389.1">
        <property type="nucleotide sequence ID" value="XM_007875198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P8I0"/>
    <dbReference type="STRING" id="1069680.M7P8I0"/>
    <dbReference type="GeneID" id="19895146"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01449"/>
    <dbReference type="eggNOG" id="ENOG502RZVD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1272757_0_0_1"/>
    <dbReference type="OMA" id="WETSHTR"/>
    <dbReference type="OrthoDB" id="5378975at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031355">
        <property type="entry name" value="YBL010C/LAA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17104">
        <property type="entry name" value="YBL010C_LAA2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="217" mass="25225" checksum="1095DADEC6AC16FA" modified="2013-05-29" version="1">MSKVPEIVNAILGPEIDSSGSYLEQDVASEHDIYVPDNSKHFLESGCRLWEKYSALKDLPPLSWETSHTRQMFLMSLDIPLNLDDTRPPNQKTKNSHVPWIKISSDTSFKDTLLKDESLTNNDIISHDFNTQMIRLIYLKSDEALLNLSSVLLKSHLLDLEIIHKQSSKYLSYWTEKKNEIESDKLVFEKVIESLVQHTKRQRIEHIKKTYNLKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7P8J4</accession>
    <name>M7P8J4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01459</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873399.1">
        <property type="nucleotide sequence ID" value="XM_007875208.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P8J4"/>
    <dbReference type="STRING" id="1069680.M7P8J4"/>
    <dbReference type="GeneID" id="19895156"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01459"/>
    <dbReference type="eggNOG" id="ENOG502RS1S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_476606_0_0_1"/>
    <dbReference type="OrthoDB" id="5382703at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17716">
        <property type="entry name" value="BRCT_microcephalin_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="433"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="572" mass="64781" checksum="F165F81F394F98E0" modified="2013-05-29" version="1">MQTQEIVEDSIKAAKTPLKATGNPSKTSFRTSSTVSSCSNTPRRLTTPARRSATRVPFQNMSLNEEPERGGCDAQKRLLSTPALRIARPLRHRTTRSSGTSETKNPKNNGNLDVLCEKRKQEKREKQNKIVSVTSSPSKNQTTLRLKRSSMITSAGHSTEEKVSFQINSNKEKGKEDLNDGRENYLKTKSCINPQTKTQLKTYLPQTNLQKKSVNKGKKEIDNKTSNMKEGFSMPVKPKKQTSNDMKLEDFLCSNKKTNIINESSFKYQETYSLDNSDPHALHTPESYKNTYHVDDKTYIYQPMVLTAKLSNMRITTPSHCRDILVPITSHYSSSDSESEYELMDKDANKLFQSIPNSSLNSSALIKESKPLGHVIAYLDIKAMDNNDASLSFKCILTELGAMIKEKWNWSVPSADMLIRMDDAYGFQSIGITHVIWRSGSTKILEKVKAANDYLEKINEPRKIHCVGINWIMKCEEEDRHVDETNYLINLDLDTFSYNKRRSMEPRALTPTLSNSIMSPSEKKPSIPKTALPKPFTELERCSLIAAKKKIDFHKPIVSSPLARKCWTISSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAF7</accession>
    <name>M7PAF7_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872880.1">
        <property type="nucleotide sequence ID" value="XM_007874689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PAF7"/>
    <dbReference type="GeneID" id="19894665"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00967"/>
    <dbReference type="eggNOG" id="ENOG502QUE3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029041_0_0_1"/>
    <dbReference type="OMA" id="GKFYHVG"/>
    <dbReference type="OrthoDB" id="10268014at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="485" mass="54815" checksum="AB1E784D772B168B" modified="2013-05-29" version="1">MNSLPCRYALLKKPGDFEPQECFYPRCLNAQIHPLVSSFFNLGNDRIILRYCHLNPVVNETKLRDCLRYTPSHFRWAGTDLFNVTNAHGQRQMIIVETNSCPSGQKSMPLLSDIDEHGGYHTVLSTAFQSSLSHSDPELGGLAVIYDKNEMEATGYATVMADLTHESVWMAEFYDSDPNPPVKWENGILYVRDKENVWHSIRACFRYVTKAPWNRIPLKTRTLVLNNIISCLAGGRNKMMAARAYELFNAEMAGTGLMIRTPETLNNISKSEIPLIISSWGGHAVVKVPYSNAGQGVYIITNQKELQDFMHTEHRYDKFIVQSLIGNASWSSVTREGMQYHIGNIPDKKGKTFVSDLRCMVTVGDVGGFQPVAIYARRARKPLLRKLDDDPLTTSWEMLGTNLSVKLPDGSFSTESKRLVLMDRKDFNTLGISLDDLIEGYVQTVLSVIAIDKLAKRLINVDTGEFDMELFRALNPDDRLLEEIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAR2</accession>
    <name>M7PAR2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_01100</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase delta/II small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873012.1">
        <property type="nucleotide sequence ID" value="XM_007874821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PAR2"/>
    <dbReference type="STRING" id="1069680.M7PAR2"/>
    <dbReference type="GeneID" id="19894797"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01100"/>
    <dbReference type="eggNOG" id="KOG2732">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021763_1_0_1"/>
    <dbReference type="OMA" id="HCILIGT"/>
    <dbReference type="OrthoDB" id="3763at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904161">
        <property type="term" value="P:DNA synthesis involved in UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07387">
        <property type="entry name" value="MPP_PolD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.50:FF:000002">
        <property type="entry name" value="DNA polymerase delta small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.430:FF:000002">
        <property type="entry name" value="DNA polymerase delta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040663">
        <property type="entry name" value="DNA_pol_D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041863">
        <property type="entry name" value="PolD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18018">
        <property type="entry name" value="DNA_pol_D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA polymerase delta subunit OB-fold" evidence="11">
        <location>
            <begin position="45"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="10">
        <location>
            <begin position="203"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR10955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="466" mass="53380" checksum="AA8272FAC9A04B68" modified="2013-05-29" version="1">MSFQDNYSSGNSNNINKPYLIRENPPFSFLHQDDYIIKKRTYQQQYANIYFLRLVHIRPKIVHKAQEKWDGIFVKKKKVKRASRLLDIVHGEVCWIIGTIYIDVPLKPNILKDIRKDYWMISSTNEKYIDSTNNDVILEDEYGRIRLIGPKVLEEFLVTGCVIGVLGFEIRDGNFQVIDICLPELPHQSLIPKKIDTKTNKYVAFVSGLNITDKTYNSLALFLLSEYLSGEIGSWKDQIASSQIVQLIIAGNSIGLSKNDNESDKRKTYNTFTYNAIPTKMLDTFLSNICITTSIILMPGESDPSNVLLPQQPIHFSMFPNAKHHFGSTLTICTNPAWMEIDGIKFFGSSGQTINDIHKYTNKIDKLTIMEYTLRWQHCAPTAPDTLWCYPFSEKDPFIMSEAPHVYFLGNQEKFDTKFIEGENGQKIRLITLPVFSETGSIVLLNLSTLECEQVKFGIHNIMSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7PBB4</accession>
    <name>M7PBB4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_00773</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872676.1">
        <property type="nucleotide sequence ID" value="XM_007874485.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7PBB4"/>
    <dbReference type="GeneID" id="19894471"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00773"/>
    <dbReference type="eggNOG" id="KOG1240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001696_0_1_1"/>
    <dbReference type="OMA" id="ATNTCRI"/>
    <dbReference type="OrthoDB" id="242910at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13980">
        <property type="entry name" value="STKc_Vps15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000497">
        <property type="entry name" value="Phosphoinositide 3-kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045162">
        <property type="entry name" value="Vps15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583:SF0">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="27"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="594"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="1148"/>
            <end position="1189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR11180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1578" mass="181239" checksum="9A2389F3CC887454" modified="2013-05-29" version="1">MGANLSSFHIFGAPLSIDSYISELSDIQYRKSLSSARFMKTVRCQHLEGPVVVKLFVKPSSSYTLKSYIEQVESVREKLLNIPNAIPYRRVFETEKAGYLVREFFFSSLYDRISTRPFLQMIEKKWIVFQLLSGLRDCHSKGVYHGDIKIENVMVTSWNWVYLVDFSFFKPNFLPEDNPADFSYFYDSSSRRVCYIAPERFLCSSELRHGELTDKMDIFSLGCVIAELFLEGIPLFTLSQLLKYKQGRYNPISTLLNKIEDLEIKSLICHMINLDPEKRLSAQEYLEKWRNSVFPDYFFTFLYQYINSIMQHSQKEHVEFKKKMFYMDDYIERIYHDLDKIAYSLGFEDYENVKKVSFSKNLYGNSITQFEVYEHSIPLAKPVSSDNGVLIFLSLIMSSIRNLLKPISRIIACHILLIFSYRITDETKHDLCLPYLAVLLNDDVPSVRMSSLYTITKLLASIIIITPINIHVFLEYILPMLNPLVTDPKSCVRILYASCISSIVNTAQRFLNIAEAFRLDGILEFAGNDIERFNGSTSSMAMTYDSSLNDLQDAFKQHVMILLTDTNSDVRRALMGSIASLLKFFYKQNIGDAILSHLITYLNDKDWMLRYSFFEHIASIALYVGSQSLEEYIMPLIIQALIDIEEFVVEKVISSLTSIMELGLFQKPRIWDLLVTLLKYTLHPNVWIRTESIKFIVASIKWLEKVDIHCILYSLLRPFLRCDIINITETALLENLHTQIPRFVFDTAIAWAARNEKSLFWKSAKSKELFVSTQYVDENDIQILFPSAKCVPLSEDEIEKTMYSHERMNISKDDEEWIIKLRDLGMTISDEWKLNLLKEYIWKVAHLSSSYRRHDNSSIVETQDGFVSLKTLDIHPKIVFSDNLSSKSKIKISQLTNTLAFEDKSEDFNKFTDKQSEDALTPSFSKNNLSVIFSNEELIPHVISDNSNIDLVTTNSSFHEERSFSTDDKQVEIGFCESSSDTKEVSNNLINIKPFLDSRISESEENRIFSSKNDESCLDNKQHNSNLIYTKTVLLNKTVPETSTNTENVLGILESFLNRYLTSNIAKDASDGEIDLDLSLFSKSVYSSDENDKDIFNFLNKIFVDNSSEEIKDFDSIVSSQKINIKKNSGKLSINTLWRPVGTLIAHFSEHSKGINRVIVSADNVFFATGSDDGTVKIWDISRLKKNVTNRSRLTYQHSMFSRIISLCFISNTHCIASGANDGSLHIIKVECITNIGPFPKYRRIKILRKYEIGKDEYAVWMEHFETDHESILMIATNMSRVIALDIRTMKELYNLLNPPQHGMPTCFCIDQQKTWLLLAGTHGILDLWDLRFQIRLKSWGLHGASKIHRLLLHPTKGHGKWVCIAGGNSQHEVTVWDIEKAQCREIYRVVKGKDTGKGYELWEIDSESSEKILRKYIENINNLSFDNKISGDNRGVCAMIVGISGMSHGITSNIINHGFIIFSGTDQKIRFWNLDSNETEKGFIISGLEPGEKMPIYTTTNLTSTLVLNTEQPISVFSADEPVSLKSFSKISRSALIQQQNCFLKNHIDLIQDIAFIDDPYKMIISVDRSGTINVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7PC13</accession>
    <name>M7PC13_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Pre-mRNA-splicing factor clf1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_00447</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872326.1">
        <property type="nucleotide sequence ID" value="XM_007874135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PC13"/>
    <dbReference type="STRING" id="1069680.M7PC13"/>
    <dbReference type="GeneID" id="19894145"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00447"/>
    <dbReference type="eggNOG" id="KOG1915">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011554_0_0_1"/>
    <dbReference type="OMA" id="AKFEMEH"/>
    <dbReference type="OrthoDB" id="541719at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000354">
        <property type="term" value="P:cis assembly of pre-catalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000048">
        <property type="entry name" value="Cell cycle control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000306">
        <property type="entry name" value="Cell cycle control protein cwf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000269">
        <property type="entry name" value="Crooked neck pre-mRNA-splicing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059164">
        <property type="entry name" value="HAT_PRP39_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF3">
        <property type="entry name" value="CROOKED NECK-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02184">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23241">
        <property type="entry name" value="HAT_PRP39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="9">
        <location>
            <begin position="84"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="10">
        <location>
            <begin position="173"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR11425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="537" mass="65566" checksum="1106FA55814769D8" modified="2013-05-29" version="1">MPRVDKFWFKYLYMEETLGNISGTRQIFERWMSWEPDEAAWHAYIRLEERYNEIPRARAIFERFIALYPEPKNWIKWAHFEQEYGTPDQVREVFTTAIDTLGEEFMDEKVFIAYGKFETKLKEYERARVIYRYALDRLPRSKSEALYNAYSSFEKQFGDKEGIEDTILAKRRVLYEEQIKENPKNYDAWFDYINLEESSGDSEKIRNIYERAIAHVPPSYQKKHWRRYIYIWIFYALYEELETKDYERSRQVYKECLKLIPHKIFTFSKIWVLYAKFEIRQLNLSVARKYLGMAIGMCPKNKLFKEYIELELQLREFDRCRTLYEKFIEYDPYNCYAWIKYAELEHMLEDYARVRAIFELAIEEQHNLDMPELLWKAYIDFEFEEGEYDRTRILYERLLEKTQHVKVWISFAHFEFSVPDDSDDNSEYSKERARNVFRRAYKSLKEQNLKEERVILLEAWKQFEISNGDEKSLKIVEDQMPQVAKSRRKLDDGSYEEYYDYIFPTDEDKRNFKLLAMAQKWAAENKKKQNSTLENST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCF6</accession>
    <name>M7PCF6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875685.1">
        <property type="nucleotide sequence ID" value="XM_007877494.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCF6"/>
    <dbReference type="GeneID" id="19897278"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03591"/>
    <dbReference type="HOGENOM" id="CLU_467008_0_0_1"/>
    <dbReference type="OMA" id="CTNTILW"/>
    <dbReference type="OrthoDB" id="5332256at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="584" mass="66956" checksum="5B1123A438F42B67" modified="2013-05-29" version="1">MLSDDVYNVSTKVISIIVSPWIIILISSMFIFSLYVFYYRPRLYYSYPSYPSSPAIYFLPPWKRIRDFNRNPIQYLLTAVSKTPHSGIIWIDVVKPYTCLSIILSLEPFMGSQFLSIGESVLSWDAALRRNWSHIFKDSKDLNNMDSFGRHSRFSKASNFCLSQAFSPCRTNIGGYYYSCIASETLVALSQNTSDSVDLKGFIDNIVIRALISIFFGSYESDYEHILRLTCTIHKSLEKSHSYDSNALKAKNEFVKVISRLLVKRTNDPETYSNGSDYVQWLLTYRSESELSIDSTMFHASLFDFSDNNDINIENQKSQSFSKILKVDIPIHLLVSLLSTWIICTNTILWVIVNQYRISEKEVPFDPNPLFLVRRAQKDILIGKFLVPKNTYLSVCSSVSSLSSFFMNRYVSQRFSVNSSEIDLRCQSLDKLKMINSINQSQGNISLFSQNNGDSVPESSSSSTNFFQSRETTISNSASESNLSVSNLRYISAPLKYHQNFNRGIKNRIYPHQHLIRLIITTVLNHVASAVVIKDKITNEKLNVYYTARHLWFPIPSRPIFVSILPATFVTSDINQKHDTFFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCQ4</accession>
    <name>M7PCQ4_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875492.1">
        <property type="nucleotide sequence ID" value="XM_007877301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCQ4"/>
    <dbReference type="STRING" id="1069680.M7PCQ4"/>
    <dbReference type="GeneID" id="19897094"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03407"/>
    <dbReference type="HOGENOM" id="CLU_750312_0_0_1"/>
    <dbReference type="OrthoDB" id="5388307at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004354">
        <property type="entry name" value="Meiotic_Rec114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03525">
        <property type="entry name" value="Meiotic_rec114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="369" mass="42540" checksum="DD461638F1B6215D" modified="2013-05-29" version="1">MKQEPFTSLSFPLERYSYATQKDEASQRHCLSNIEWFHYPHRDLEIQFEMNNVSGHDEVTMKITRGAILFEQLNITRLSRLKIPLFQSENGPPQSGIIVITRAPCIGIKWYNDVSRKISRFQMKFSTEDIFHSVRGILEQHVGKIRNAIDSYSSNERVSLKVQKYDKSSDHVKPWIEGEMEEPQAKKIYGGQGSIEPFFPLNSIGSMEKEPISSLADLRFPTPSNTNRFLYLNPSYNKNQNEWVSSIDELSKMTKENNHYDPSLSTELIKKKKLKKSSKTKKNLNDLKKEPSADNNSLLIKTDVGKKKTSTVKKLPTPPRTASYESSLSLSQENTDTLEEMIVSYINDHHFLQLIKKVDTIWKKLGFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7PD69</accession>
    <name>M7PD69_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Threonine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_00254</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872125.1">
        <property type="nucleotide sequence ID" value="XM_007873934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PD69"/>
    <dbReference type="STRING" id="1069680.M7PD69"/>
    <dbReference type="GeneID" id="19893952"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00254"/>
    <dbReference type="eggNOG" id="KOG1637">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008554_0_2_1"/>
    <dbReference type="OMA" id="WYADGMY"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000009">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000006">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000005">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="14">
        <location>
            <begin position="37"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="267"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR11830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="682" mass="80282" checksum="B67B3A09826694AA" modified="2013-05-29" version="1">MNDRYLLEKPVFIDHRISMFERLYDEFKREIQDKERLEIEITLPDGSSLKGVSWETTPLEISKRISKSLSERVVIAQVNDVLWDLERPFEKSSTLKLLDFNTPEGKKVFWHSSAHILGEAAERYYGCYLCIGPPTDDGFFYEMAISNRTVLKQDYSDLENLIKFIISEKQPFQRLTVTKENLLEMFKHNNYKQTIISSKVPDGESSTVYRCGTLVDFCMGPHVPHTGKIKALSILKNSSSYFMGDVTKDSLQRIYGISFPDNKQMLDYMNFLADAEKRDHRRIGREQELFFFHELSPGSCFFLPHGTRIYNRLLEFIKSEYRRRGFNEVITPNIYNSKLWKISGHWQNYSENMFSFDIEKERYALKPMNCPGHCLMFAMHDRSYRDLPLRYADFGVLHRNEFSGALAGLMRVRRFQQDDAHIFCTFDQVKEEIMNCFEFLKYVYEIFGFSFRLKLSTRPEKFIGDIETWNRAEKSLETALNNFGLPWEINPGDGAFYGPKVDIEISDALRRHHQCATIQLDFFLPECFNLEYRLASDEKKKSIYARPVIIHRAILGSIERMIAILIEHYGGKWPFWLSPRQVMIIPISKAFKDYSKHVYDKLYDNGFYVDIDLSDNTLNKMVRNAQIAQYNFIFVIGQEELDSNTVMIRNRDDQSKHIRILLDDVIIKLRYLQLCRKNENSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M7PDE8</accession>
    <name>M7PDE8_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_03310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875386.1">
        <property type="nucleotide sequence ID" value="XM_007877195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PDE8"/>
    <dbReference type="STRING" id="1069680.M7PDE8"/>
    <dbReference type="GeneID" id="19896997"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03310"/>
    <dbReference type="eggNOG" id="ENOG502RZ6E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2292882_0_0_1"/>
    <dbReference type="OrthoDB" id="5587740at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="Ribosomal_bL28/bL31-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034600">
        <property type="entry name" value="Ribosomal_bL31m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048874">
        <property type="entry name" value="Ribosomal_bL31m_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL31M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21492">
        <property type="entry name" value="bL31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="L28p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein bL31m N-terminal" evidence="4">
        <location>
            <begin position="30"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="101" mass="12176" checksum="0A5AAEB168AD84DC" modified="2013-05-29" version="1">MNISRYKYFKYKEIQQINKYGARNIAQRLARPRQFQQIVVLSDKSTFTIPTTSPKPVIWITKDQRNHPLWNPNKKQQIDENDNESRLSKFKQRFGTKYNIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7PE54</accession>
    <name>M7PE54_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">m7GpppX diphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Decapping scavenger enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Scavenger mRNA-decapping enzyme DcpS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_02922</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65388"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58285"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="EC" id="3.6.1.59"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.59" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874964.1">
        <property type="nucleotide sequence ID" value="XM_007876773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PE54"/>
    <dbReference type="STRING" id="1069680.M7PE54"/>
    <dbReference type="GeneID" id="19896609"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02922"/>
    <dbReference type="eggNOG" id="KOG3969">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041045_1_0_1"/>
    <dbReference type="OMA" id="HVHINPI"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140932">
        <property type="term" value="F:5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000006">
        <property type="entry name" value="m7GpppX diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.40">
        <property type="entry name" value="Scavenger mRNA decapping enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008594">
        <property type="entry name" value="DcpS/DCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011145">
        <property type="entry name" value="Scavenger_mRNA_decap_enz_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978:SF0">
        <property type="entry name" value="M7GPPPX DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05652">
        <property type="entry name" value="DcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028973">
        <property type="entry name" value="Scavenger_mRNA_decap_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102860">
        <property type="entry name" value="mRNA decapping enzyme DcpS N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR028973-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR028973-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR08749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="306" mass="36303" checksum="75CD7EF5B28C13FE" modified="2013-05-29" version="1">MNDEYVKNIKNFVFESVLNEDSRLKYITLLGHIFDTKAILIIEKTTLELKDAMLFIEENGLFFELIEKNDIYHLFLGGIPFYDKKSPYAKITLIYPASEIHIKKYSRQSKCRVQETPEIYELYVKPYIETMKGPRIKWVYNILDHLAEKEHILYEYPDKENGFIIIPDLKWDQKTVSTLYYVAIVHRRDISSLRDLKKEHIPLLLHIKQAALDIIPKKFQEISQDQLKFFIHYHPSYYHFHVHISHIDFDSGDGMDVGRAYLLEDIINQLETMSDNFSFIQRTLTFFLGKKSDLWLNVFSSIMNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7PEB6</accession>
    <name>M7PEB6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Programmed cell death protein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875009.1">
        <property type="nucleotide sequence ID" value="XM_007876818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PEB6"/>
    <dbReference type="STRING" id="1069680.M7PEB6"/>
    <dbReference type="GeneID" id="19896651"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02964"/>
    <dbReference type="eggNOG" id="KOG2061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031771_1_1_1"/>
    <dbReference type="OrthoDB" id="443682at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524:SF1">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Programmed cell death protein 2 C-terminal" evidence="2">
        <location>
            <begin position="254"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="373" mass="43373" checksum="8870017DEEE272A1" modified="2013-05-29" version="1">MNTKPVLLAFPDEYTRAEDLASDPLITRLGGLPIGLDRLTKPPLKFSKCRNCNQIMPLILQSYAHIDNIDYDRVIYVWACCHRRCQYKEGSVRVIRGILYQKTKNTKTKHSLDDKFHHNSLKSLGNTLFNSPFPMSSYPSNPFRMNFSAKTEQNSSARSNLPELSNIKNSQIGSFSYQNVYQSKINEIEKEEWPPDNEILQYHIKILRIVEENEQNLEELTEKLKIENFKEKFVKDNEKDQWSGEIFEKSTLEKGFRMFIKKIRANPQQCVRYNRKGQPLYYSLKDLLAKKIEFSESENPLGKCQLCNSQNVFELQIMPNTINILEENVSIGDMLWGTIIIGTCSNDCIPNLNDKGIGYTEEWVGVQWEEMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7PES7</accession>
    <name>M7PES7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1753 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874775.1">
        <property type="nucleotide sequence ID" value="XM_007876584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PES7"/>
    <dbReference type="STRING" id="1069680.M7PES7"/>
    <dbReference type="GeneID" id="19896436"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02745"/>
    <dbReference type="eggNOG" id="ENOG502S8B2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1205202_0_0_1"/>
    <dbReference type="OrthoDB" id="3338076at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070917">
        <property type="term" value="F:inositol phosphoceramide synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006673">
        <property type="term" value="P:inositol phosphoceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013862">
        <property type="entry name" value="Kei1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077:SF1">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08552">
        <property type="entry name" value="Kei1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="29206" checksum="1150E9553264A9A5" modified="2013-05-29" version="1">MLRVKHFEIPKPTSFLYFLDLQIGTELIIFFSILNKASGIYGFFVTLINYSSLSMSLWKMFMYFYSLLVLLGFTMMIKYIRIESPFHILICAYFYFIDTFISSLYSAIFTIVWFMNIFKHAIISSGVGKLVSSQKSEIIELWSSNNSEYAHDNSIMFFSIENLFTVFILCFFLCLKIYFCLVVFSYARYLFLRTGNMYKYLHNERIKKLVSLLTYGKYWEKADNTSRKIKCSLDLKVFNARLLDGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7PFT5</accession>
    <name>M7PFT5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome maturation protein SDO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_02264</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874253.1">
        <property type="nucleotide sequence ID" value="XM_007876062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PFT5"/>
    <dbReference type="STRING" id="1069680.M7PFT5"/>
    <dbReference type="GeneID" id="19895957"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02264"/>
    <dbReference type="eggNOG" id="KOG2917">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043216_1_1_1"/>
    <dbReference type="OMA" id="TIISAKC"/>
    <dbReference type="OrthoDB" id="10253092at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990932">
        <property type="term" value="F:5.8S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1250.10:FF:000001">
        <property type="entry name" value="SBDS, ribosome maturation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018023">
        <property type="entry name" value="Ribosome_mat_SBDS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046928">
        <property type="entry name" value="SDO1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF1">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20268">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01267">
        <property type="entry name" value="UPF0023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="9">
        <location>
            <begin position="14"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS central" evidence="10">
        <location>
            <begin position="109"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS C-terminal" evidence="11">
        <location>
            <begin position="174"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR09304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="247" mass="28739" checksum="EC2B27280207936F" modified="2013-05-29" version="1">MVINQPSNLIKLTNVSIVRLKKEGKRFEIACYKNKVVEWRNGVEKDIDEVLQINSVFTNVSKGQIACMEDLKRIFKTEDINEILYEILKKGEMQVGEKERLYQIENVYKDIVRTIVDKCVDPTTKKAYTTYMIEKALKNIGFSVNLNKNVKSQALDAIKQLKKRNVIPIERARMRIRIVVPLKKNNGLKEELKQLMTVVTEEERSDELHAIAYIDPGDYRRIIDIVRQGNHDKGYVEVLDLKEIIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7PGH8</accession>
    <name>M7PGH8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guanylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_02150</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874131.1">
        <property type="nucleotide sequence ID" value="XM_007875940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PGH8"/>
    <dbReference type="STRING" id="1069680.M7PGH8"/>
    <dbReference type="GeneID" id="19895843"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02150"/>
    <dbReference type="eggNOG" id="KOG0707">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001715_0_4_1"/>
    <dbReference type="OMA" id="EWAVVHG"/>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.10:FF:000002">
        <property type="entry name" value="Guanylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000776">
        <property type="entry name" value="Guanylate kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.10">
        <property type="entry name" value="Guanylate Kinase phosphate binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR09564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="178" mass="20374" checksum="BE57AE335482AA7C" modified="2013-05-29" version="1">MRSGKSTLIRRLFANHPGRFGFSVSHTTRPPRTTEKDGVHYHFTTNENFLKLISEGAFIEYANFSGNMYGTTAKAVEEVMAKGYTCIMDIDMQGVLSIKKAPIRAKYVFIAPPDLDVLEERLRKRGTDAEDSIRERLKRAAFEIEYANRPGSHDLVLVNDDLDETYEKLEKFCLENEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7PGR0</accession>
    <name>M7PGR0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial distribution and morphology protein 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_02226</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MDM31/MDM32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874210.1">
        <property type="nucleotide sequence ID" value="XM_007876019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PGR0"/>
    <dbReference type="STRING" id="1069680.M7PGR0"/>
    <dbReference type="GeneID" id="19895919"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02226"/>
    <dbReference type="eggNOG" id="ENOG502QQJG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016236_2_1_1"/>
    <dbReference type="OMA" id="DFLCAEN"/>
    <dbReference type="OrthoDB" id="17678at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012571">
        <property type="entry name" value="Mdm31/Mdm32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068:SF0">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08118">
        <property type="entry name" value="MDM31_MDM32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR09644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="677" mass="78880" checksum="DE84F2FD463934F6" modified="2013-05-29" version="1">MYLKTRLICFHGRQSFSSEMEKNLWRTMKYRFFFLKGIDPVWRGRRYCFLSLNQEKRLDFDDKNEKKRRWNYFLKNIIRRHYSRTIFSQKYSYSVSKVFETGLFKIKGIFGNFGLFFKSRNLVANYSELSSYKFPLRAPSITETYRPTKEVLLSSTSGFFGRLKIRMKYRLMRQIRPFNIDDISAMFTWLIACNILWIIVGTTTFFSLVLAAANSVFAQEYLATKIGEYLTKETGITVLFESAIVPKWKDGTISFRNVFISRSPYNQNLKNNVRKGIISEISGVITENTTNSFDFYPEKESNYTQFHLIIENIDVVFSFVKWFSGTGIIKDIDIKGVRGVIDSSNINLDNDASPLSPKFLRKNRQSSSFEIENFRLKNVLVTVFQSKNFRPFTVSIYNCELPRLRKQWLLYDILNANTISGSYDNSLFTLHPHQTFLSNIDEKKDKEAKKTRLRIDNVNIDHINKGIEGPIGWITYGYVDFILDFVFPNENENINFMKAMHNIIDNIETIFIKQENEGEKGAFILQDTINETSPELLRELVQIRDFKNSQIVSTKDIIIDIKVALHGVKANVPLFKKQLSYVSNALIRPIVAYINSHNTYISVACKVIKNLDDFNGSWTIYDSELINELSKEIYNAFANIVMNQDVKRHYIRTISAWSLEMAIHAFLTSLIGIIHPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>M7PGR5</accession>
    <name>M7PGR5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="3">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_02232</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874217.1">
        <property type="nucleotide sequence ID" value="XM_007876026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7PGR5"/>
    <dbReference type="GeneID" id="19895925"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02232"/>
    <dbReference type="eggNOG" id="KOG0902">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TIEVWQS"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061909">
        <property type="term" value="P:autophagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140504">
        <property type="term" value="P:microlipophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05167">
        <property type="entry name" value="PI4Kc_III_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000011">
        <property type="entry name" value="Phosphatidylinositol 4-kinase alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000012">
        <property type="entry name" value="Phosphatidylinositol 4-kinase alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000014">
        <property type="entry name" value="Phosphatidylinositol 4-kinase STT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045495">
        <property type="entry name" value="PI4K_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF15">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19274">
        <property type="entry name" value="PI4K_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="9">
        <location>
            <begin position="1336"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="8">
        <location>
            <begin position="1621"/>
            <end position="1889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR09649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1905" mass="218920" checksum="C1313702E28B3A03" modified="2013-05-29" version="1">MDCIFTDIRRTALRRLLILSFDKDGNEILAKSKQTWEILVKNKLKSQKGGILNAIGYKSQKKDIIQMTPREFHATITICEAIIDSKHLNCTKEFIYEIAAILKSSYGSFTLSSFLDVDKVFYLKDLANKSTLSLLRFMDMFPGCKTEILNIFTEYIEEVLVELKNSLDSSIISEIHVPFTSLCGFLKGLKTSKFFQSDFKITVILEPLKYLLSEDFLSKILNLIIKFENENINQNNITFLTKKHSNDLVLGKCLILTKNLIFIIQKYIFKQIVGNDIFDWEEILTDNTLNFDHVHLEFSTITSIVQCLKDTIKYLSAFSRSNIVESNTFQKVFSYSLRTTCLCCMIIKDFSLMSKWFEKLLEFSHEGFSTIYTIAIQDVFAAIALCFPDNASVIIQYFRMHILHFSDSITNLQHNDELTALVSKRLTYVLKHSSQDAIITTIYSLANSISSNIPKTPSADLLIPLDQRTVRSSISLIFKTDSQRRIIHYKIVDAITQIAIMIPDEKIAALSISILIQKYGKIDIEVDKIILEKLANVTKAKSEKNVMSIIKFYSRVAEGLYGYGLDTVSDVFQSSLAKISSNMEQKSGLLTFYLNNLLNIIIRFDKVPEKQNESEKKSKNRDLKNIQDNILNILHPLAILLQKFDIEHSFDSETILLFCNMWFTFVLCGFTKGSSLVNQNIESLKIIATYSPPLVLDNVTTHFESDLELNTVLRRGGSQKDLNFLRETLSKALPSCAYEIRSASYSKTVYLSSVFLLETLRSSAGICSYTFAYLKNTNIKESDIATCISVIAHSATNVFISSFVFSSKEPETSLLLSKEMKRLLLSCSHRMKQPRELALKCCDKVISSMPSVLCSQSVLYTLLESLSLLWYSCANEYLSEYTPQYIFSSSRGHLSLEFSDSYIERKIILRDLLTYAKRWLSLALQISPLDLKSLLHTYLSDFDDSSSTCNISLGKTVALDIGGSLSYIDKKMFGDLLTNVSSEFISEYTIRQLNKFPASILHPMRNGNNSYTIQNDFSDNGFITSVLQNISQIENDLKQKKRLEIKELKDSLQKVATCIITGTEYEKILARYIVRIPFMILNVPSIKLGISLWTWIMTERPSLHIQLLTEISRNFQWSIRRRQGLFSNSIDPLNAFAKPMEYLPTDRTIYDKEIQRASKLFTPHLLLTNFLSSHLQAFHKDYNVFNVISSFFRFIGIAILNKKSSKHILSRELHLHLFNLGFKILKFKDIDPIIFIKTRKVLYSAIFAWFSRTPKWAFGGNKIQLETELNLLTVIQSAIEGDNIIMTSTFYDELFDNSIHEKQQKLLYLLVSHEKYRISTWLNVREIGLSTYNITTLWENISDEQWKTFVNTAWNHDPILAINLVHRFKSKDLHKKLRDLILENPFNVIDCPCALSILFDNFSDVTAFQLKYLQFWSPVVPLTAITYFLPIYNNDGFILQYAVKILEHYSLDVIFFYVPELVQALRYDTLGYIEQFIVETSILSELFAHQIIWNIKANSYKDENALEPDSIKPVLDRVVERITSCFTGEKKEFYEREFNFFNKITSISGKLKPYIKKSKLEKKEKIDLEISKIEIDSGVYLPSNPDDIVIGIDRKSGKPLQSHAKAPFIATFRVKKKKEAYTNMERKISEENLNNDLNTEFNQESWKSSIFKVGDDCRQDVLALQLISMFRNIFNDIGLSLYVFPYRVTATSPGCGIIDVLPDSISRDMLGREAVNGLYEYFITKFGNENSIEFQKARNNFVQSMAAYSVITYLLQIKDRHNGNIMIDREGHIVHIDFGFLLDIAPGGIAFESSPFKLTREMIAVMGGNQKIQPFIWFQELCIKAFFACRPYAENIIECVILMLDSGLPCFKGTTTINNLRSRFHLDQEDHEAARTMIKLINNSYENKRTVIYDQFQSITNGIPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7PIP6</accession>
    <name>M7PIP6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thioredoxin peroxidase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01571</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873524.1">
        <property type="nucleotide sequence ID" value="XM_007875333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PIP6"/>
    <dbReference type="STRING" id="1069680.M7PIP6"/>
    <dbReference type="GeneID" id="19895266"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01571"/>
    <dbReference type="eggNOG" id="KOG0541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072440_3_1_1"/>
    <dbReference type="OMA" id="FIRTKDQ"/>
    <dbReference type="OrthoDB" id="195498at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000020">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF16">
        <property type="entry name" value="PEROXIREDOXIN-5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="6"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="8">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR10314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="173" mass="18921" checksum="2C83EF8F6DA5A759" modified="2013-05-29" version="1">MALSILKKGSKLPFGTFTYIPYDGNKCSFNGEGVPVEVTTDDWKNLKVVLFSVPGAFTPTCSSRHLPDVINHYEELKAKNVDLVAFVAANDPFVMAAWGDAFQARDKIHFLTDTDANFSHSIGYSIDLKTQGFGIRTGRYAIVVDRGVVIYAEVEKDPNIVTTSGVKAVLANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7PIW2</accession>
    <name>M7PIW2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protection of telomeres protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_01636</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the telombin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873593.1">
        <property type="nucleotide sequence ID" value="XM_007875402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PIW2"/>
    <dbReference type="STRING" id="1069680.M7PIW2"/>
    <dbReference type="GeneID" id="19895330"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01636"/>
    <dbReference type="eggNOG" id="KOG4757">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016663_1_0_1"/>
    <dbReference type="OMA" id="PWMECCV"/>
    <dbReference type="OrthoDB" id="2186770at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000783">
        <property type="term" value="C:nuclear telomere cap complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098505">
        <property type="term" value="F:G-rich strand telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010521">
        <property type="term" value="F:telomerase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032210">
        <property type="term" value="P:regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000303">
        <property type="entry name" value="Protection of telomeres protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028389">
        <property type="entry name" value="POT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032042">
        <property type="entry name" value="POT1PC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011564">
        <property type="entry name" value="Telomer_end-bd_POT1/Cdc13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513">
        <property type="entry name" value="PROTECTION OF TELOMERES 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513:SF0">
        <property type="entry name" value="PROTECTION OF TELOMERES PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02765">
        <property type="entry name" value="POT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16686">
        <property type="entry name" value="POT1PC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00976">
        <property type="entry name" value="Telo_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Telomeric single stranded DNA binding POT1/Cdc13" evidence="9">
        <location>
            <begin position="21"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR10384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="521" mass="60316" checksum="A08756D83537AA25" modified="2013-05-29" version="1">MSIESFPSNAVYYFRTQYNEYQYISNLQTGSIVNLTGIVASFKDSRKSRGTDFTNSCIIFDKSCAIPGGGLLINFFRPLKKDLPLFNDDTGAILLRNLRINPYNINMQGISRIDTEWILFDKKGNMQSKSNNKISLLFEEETFIKDLCFWWKDKSGLAHGIISKKRPILIRDIIPNSFYEIIGEIVKTFPINSNGYTIYLTDYTSNSLLHSYEWGMSSKWNGPYGKMTIQCSLWDSTAMFARNKLYEGEIVQVSNLLGRLNRDGILEGVVHGDKQYPDKIFITKPSKDNFYVKELIARKSLYNKKFLNDKKILKEISKENQYKEKTTVLTSSANINLNIVCAHQHIPITQIGDILSSLNPKPLYVAQKFRIRARVIDFLPVNLEDFARPFCKSCQETYIKKCRCYSVYPLDEVFIWQFAFLFEGQDSACIPVIFFGDDAQMLLNNESIMPTNLRKDKKTLALLRQKLSLIYGDLEETLLSGQHYNHIQTPWFELCIMEYIVHESKTGKEQRRWRAFGIKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7PIW9</accession>
    <name>M7PIW9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01109</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873024.1">
        <property type="nucleotide sequence ID" value="XM_007874833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PIW9"/>
    <dbReference type="STRING" id="1069680.M7PIW9"/>
    <dbReference type="GeneID" id="19894806"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01109"/>
    <dbReference type="eggNOG" id="KOG1601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1649">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014421_3_0_1"/>
    <dbReference type="OMA" id="VEVQGIW"/>
    <dbReference type="OrthoDB" id="10258327at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033696">
        <property type="term" value="P:heterochromatin boundary formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GATA-type" evidence="7">
        <location>
            <begin position="376"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="333"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="428" mass="47650" checksum="F91E4A48A57E4779" modified="2013-05-29" version="1">MLKPSLPVFGVITTYASRIRTGNTSLIIPVQGQPGARSTGRLSSRGSVISYAEKEDDDWDQIAENGHETYIADIDDNGDNKGLMNGPPPDSVVKRKPAVKTRHMYRSDDQMKFAAENEEVLIPIRLDLELDNYRLKDVFTWNMNEELITPDLFAQVMCADLDIPASVFAPQISSAIRTQIEEYAPVAEISLPENNDLRVIVNLSLHLSRHLLTDKFEWDLTGSLTPEVFASQVCADLGLGGEFYPAIAHAIHEHLFRLKKEACEGGLPFELDNDAAYGAEAGIRVEQETLGASWAPHIEILSREEIEKRDGDRERQVRRTRREASRFNIGTISSFGERKGGRDKRGRSISPTGRGTSIEHGIPAGVSGAQTLSDYERTRWRCSYCHCSGTGTWAVRRGPSGNKTLCNPCGVAYAKTNELPMWRKGLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7PIX4</accession>
    <name>M7PIX4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED19</name>
        <name evidence="11" type="ORF">PNEG_01114</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873029.1">
        <property type="nucleotide sequence ID" value="XM_007874838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PIX4"/>
    <dbReference type="STRING" id="1069680.M7PIX4"/>
    <dbReference type="GeneID" id="19894811"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01114"/>
    <dbReference type="eggNOG" id="ENOG502R765">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1525805_0_0_1"/>
    <dbReference type="OrthoDB" id="2160599at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013942">
        <property type="entry name" value="Mediator_Med19_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28270">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28270:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08633">
        <property type="entry name" value="Rox3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="145"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR10399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="176" mass="20456" checksum="6D4B65B93EC72763" modified="2013-05-29" version="1">MDEQKEEIQTFHFVNYSSHSITLPSVTDDLQKMYGLSSLASRVARVDEFGNKKKMRQSYKGHIQQFPGKNVILKDRFIRDLIFGPKEEKLDKFIENLDSELIEAAFSLQPGPVPGFDSSVFGSSNTEKKNELYNEKDTMLSVSLENFKRHSKKKKRKHEDYEQSIGLEQKKYRKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJ26</accession>
    <name>M7PJ26_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dolichyl-diphosphooligosaccharide--protein glycotransferase</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PNEG_01168</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endomembrane system</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873083.1">
        <property type="nucleotide sequence ID" value="XM_007874892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJ26"/>
    <dbReference type="STRING" id="1069680.M7PJ26"/>
    <dbReference type="GeneID" id="19894865"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01168"/>
    <dbReference type="eggNOG" id="KOG2292">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009279_1_0_1"/>
    <dbReference type="OMA" id="TWYAIGT"/>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="203"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="17">
        <location>
            <begin position="22"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="STT3/PglB/AglB core" evidence="18">
        <location>
            <begin position="561"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMR10454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="760" mass="87863" checksum="1C2C7B50E3D00736" modified="2013-05-29" version="1">MNQVYKTSSSSKETIRNVRGILKILIFITISASSILPRLFSVIKYESIIHEFDPWFNFRATKYIISSSLDEFWNWFDDRTWYPLGRVTGGTLYPGLMVTSYIIHSIFHFFNYPIDIRNVCVFFAPAFSSLTTIATYFFTKDLKDESSGLLAAALIAIVPGYISRSVSGSYDNEAIAITLLMTTFCLWNKAIKTGSSFFGSLTAFFYFYMAAAWGGYAFIINMIPLHCFCLILMGRYSSKIYVAYSSFYTLGTLMSMQIPFIGFQPIRSNEHMAALGIFGLIQLIAFTNFIRSHISDKKFHDLLKYSVFFIFLLSFLLLIVLTITGTISPWTGRFYSLWNADYARIHIPIIVSVSEHQPTSWSYFYFDFSLLIWLFPVGVFFYFQKLENEHIFAIIYSIMASYFSGVMVRLILVLAPIVCVSSALGLSLLLDKYLVFPEIWFKIISSSSKAKSDVSTSKAIYQKAQRSIEKRKYYISSTFKTSKGMSNEFVKSRIPKVILIATFFYYLVMFVNHCTWITSNVYSSPSVVLSGSTSQGRDYIIDDFREAYYWLRQNTPYDTKIMSWWDYGYQITGMADRITLVDNNTWNNTHIATVGKVMASPEEISYPILRKHDVDYILIIFGGLLGYSGDDINKFLWMIKIAEGIWPNEIKESDFYSYYHGYRVDEYATPVMRNSLLYKMSYYNFNKVYGKGHSYDLVRQQNIPSDDISLNILEEAFTTENWLVRIYKVKSPDNLGRDTFTKKIQSNQNTDEIHKILRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJQ5</accession>
    <name>M7PJQ5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosducin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872749.1">
        <property type="nucleotide sequence ID" value="XM_007874558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJQ5"/>
    <dbReference type="STRING" id="1069680.M7PJQ5"/>
    <dbReference type="GeneID" id="19894538"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00840"/>
    <dbReference type="eggNOG" id="KOG3170">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072604_1_1_1"/>
    <dbReference type="OMA" id="FCEIRAN"/>
    <dbReference type="OrthoDB" id="45518at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051498">
        <property type="entry name" value="Phosducin-like_chap/apop_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809:SF3">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="2">
        <location>
            <begin position="20"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="189" mass="21919" checksum="69E252F95F3495A2" modified="2013-05-29" version="1">MEDTEWNDLLRAYGIVSARIQEKEADSSKEIQEPYVEELKSSEHSELDDLDDPVVKAYSERRLQELQAYAACAKYGEIRMIEYKEWITEVTEASYNTCVLVFLYKDTISASQRLAEKLKQIAMKYPYIKMVKIQGNKAIQGYPDKNLPTLLIYKLGNLIGQKIVNLGNIEEVENWLKELNVLNEEEIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7PKA6</accession>
    <name>M7PKA6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RecQ-mediated genome instability protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872943.1">
        <property type="nucleotide sequence ID" value="XM_007874752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PKA6"/>
    <dbReference type="STRING" id="1069680.M7PKA6"/>
    <dbReference type="GeneID" id="19894728"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01030"/>
    <dbReference type="eggNOG" id="KOG3683">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1240588_0_0_1"/>
    <dbReference type="OMA" id="MTSPDQI"/>
    <dbReference type="OrthoDB" id="341511at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049363">
        <property type="entry name" value="RMI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790:SF15">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1 RMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21000">
        <property type="entry name" value="RMI1_N_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01161">
        <property type="entry name" value="DUF1767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RMI1 N-terminal" evidence="4">
        <location>
            <begin position="12"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="3">
        <location>
            <begin position="63"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR10884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="223" mass="25640" checksum="D70CE19DB600805C" modified="2013-05-29" version="1">MNLRAEKVLKFLESKFLYVHLNWVEETLHQIDVSLNDKQLEQQIIQYLLNSDIKKSLTFQSCLPADIFDKHNQVLPGPYCLQIIHVQDIGISIFNQLEYLEQFDESGTIKSYNVIWNNLSDIDDDEILDTDKPASKKFCKLLLEDSSGLCVWAIEHKPIKHIHIGINLGTKILLKNILVLRGVLILNPSNITFLGGQIFELNKNYFPSGLKNQLKSALYNMNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M7PKH6</accession>
    <name>M7PKH6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major surface glycoprotein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01104</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873016.1">
        <property type="nucleotide sequence ID" value="XM_007874825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PKH6"/>
    <dbReference type="STRING" id="1069680.M7PKH6"/>
    <dbReference type="GeneID" id="19894801"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01104"/>
    <dbReference type="eggNOG" id="KOG3544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010455_0_0_1"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021041">
        <property type="entry name" value="Maj_surf_glycoprot_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003330">
        <property type="entry name" value="MSG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053121">
        <property type="entry name" value="Spore_Coat_Assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35365">
        <property type="entry name" value="LP04239P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35365:SF18">
        <property type="entry name" value="MUCIN-19-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02349">
        <property type="entry name" value="MSG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12373">
        <property type="entry name" value="Msg2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004083005" description="Major surface glycoprotein 2 C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="domain" description="Major surface glycoprotein 2 C-terminal" evidence="3">
        <location>
            <begin position="948"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="144"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="667"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="855"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1193" mass="137869" checksum="C14C55930BFD9FA1" modified="2013-05-29" version="1">MKSISFAFFAYLGCILVAALENVMISDINEQEHQVVELFENERPLRLRKIRGSKGTWNSRFNKDSNMDYFENYPGVDYFRKDDYETFLPEDYPQDNQWVEEITQKRAVTVQLVKRQAAGQAVGNDEIKEEHILSLIVKSDYSNNDKCKEKLEEYCAELKKIDEKLENVDAKVKELCKDGKQGEKCKELKKKLETESGTFKTEVEEALNGLTDENYRKCEKKCLLLENLDKDFIEKCSQLKNKFYKKKRQEVAEEILSRALEVVGERGGVNDTNKCEERIKGICQRLSEYSDELMFSCLNPNETCKRLKDRLENVCHLIKKSLQNNELIEKCPEYLEKCHFYSKNCNETKCKEVKEHCKSKKITYKTQESDFNPIKAKASFLEKIGLEDLYKKMESKGIIIRKLQKKTLQDVIILLSKENNGKDREEKCKEELKNCDKFKYLGINLELLCKESKNKDKKCKELLDLKIRCRKLKFKLFFEKLSTEFEEDKDSSLFSWQELPSFFTIEVCIELVSECFYLENLCTNKIDKACENARLACYKKGQHRILDKAFDNYIKKEYDDGVFGNMCSKTLLINHHKFNYDIRYVIKFLRLREYCLELFFDVSHNLEELKKALNDARKHLQEKDCIELKKRCNYLRIYSNVIDRKCYMLDTRCRYSKLIREFRTNLLKKKSNILENQNNCKKALKEECDRLIRRGENAFNILCVLLEETCEFMVKLTKGDCASLSINLSEDVINKIKNANETLIEEMCKLWDPYCDQYMENCPEILKNDPTSNGQGVCLQLKKKCDPFWKKLQLEEELIYKLKSSLHSLIKCKETLKEYCTKWEEEKNQTFDSACNDKNDPSNYFKKTEVCDELIKKVIKKCPALKNNLDKLKIDLKKKKDNYEKMKQEAENSIKKANLLLLRPKKNENGQSAVSILQNINAFTPATPSAAPAESASSQDRTTNTTKLRFLQRTFADERISESEVKAFDATVIALELYLELKEECKAQQPDCDFRKVCQNFGTVCEDIEKLCEIKPLEVAPYHTMTSTMISISTTAAISTITTTLTTPTAAILTIAATTTTTTTTTTTTTTTTTMTMTMTTIKGGKVIEQCTLIRTINTSVTSTSLHTSTVTSTSLHTSTVTSTSLHTSTMTSTSTLTSTVTLKEKCNPTRYATDSSKETKMREEVIPGGGMKIRVPEMIKIMLLGVIVMGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7PKN8</accession>
    <name>M7PKN8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00623</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872521.1">
        <property type="nucleotide sequence ID" value="XM_007874330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PKN8"/>
    <dbReference type="STRING" id="1069680.M7PKN8"/>
    <dbReference type="GeneID" id="19894321"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00623"/>
    <dbReference type="eggNOG" id="KOG2294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_510088_0_0_1"/>
    <dbReference type="OMA" id="DICAWIR"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000260">
        <property type="entry name" value="Forkhead transcription factor (Sep1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF343">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="8">
        <location>
            <begin position="163"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="163"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="534" mass="60219" checksum="D370D2DEEFFE8E1D" modified="2013-05-29" version="1">MTTHLSYMTSISTPESQYTIASPAPLYSVSPSKIFRQDIPRSPCKSNISFKSTSSLLPPPMKSITNQHYKAPSKTSIKTSLASQYPPLPTFSKDNFGIHSPTSLLDDKENIAPNSFSIPNAKLSKGSSRQDSHESSKNISIPLENLVIPEPHEMPLIEDDGQKPPYSYATLIGMAILRAPQRKLTLSAIYHWISHTFEYYCNNDSGWQNSIRHNLSLNKAFVKQERPKDEPGKGNYWTIEPGYEFQFMKGRTRKNTSISKRPTLIPSITIPQIEKKRSLIENIIESDRETQSCIKRSKIENHMNNTLPSSSYQRCDTTPSSVHEETDMHPNKNEYFNNFSQCQTALSKQIPLQNHLESHSTTTMLDFISPPVSPRHESIFNPAPYSPLTPVLTAQTTSVLPNSSPTTCLRKHRDHIIKLLGTSEDNQAFTEEDLWENGSTNNSPNPHIPIFEDDDIVSKACFGSPDKREAKRREIRRSLISGLHSKELYAMEGVSEIIDIFGIDIVSIVRREIERIKQNENSTSGNTALEECLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7PLH4</accession>
    <name>M7PLH4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00317</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872191.1">
        <property type="nucleotide sequence ID" value="XM_007874000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PLH4"/>
    <dbReference type="STRING" id="1069680.M7PLH4"/>
    <dbReference type="GeneID" id="19894015"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00317"/>
    <dbReference type="eggNOG" id="KOG1657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045277_11_1_1"/>
    <dbReference type="OMA" id="EDIHSCS"/>
    <dbReference type="OrthoDB" id="636685at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23645">
        <property type="entry name" value="HFD_Dpb3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF54">
        <property type="entry name" value="CHROMATIN ACCESSIBILITY COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="3">
        <location>
            <begin position="16"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR11289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="115" mass="12981" checksum="399FC5DF995C3E7E" modified="2013-05-29" version="1">MTSAIIDQDITGTSVLPISKVKKIIRIDDDIVQCSSNSAFLIAIATEMFIQYMVQQGLLMCLNENKKTIQYRHLANAVSRIDNLEFLSDTIPKTIAFKDIPSKKNIKSTDQKYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7PLJ9</accession>
    <name>M7PLJ9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit C</fullName>
            <shortName evidence="4">eIF3c</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 93 kDa subunit homolog</fullName>
            <shortName evidence="4">eIF3 p93</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Translation initiation factor eIF3, p93 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NIP1</name>
        <name evidence="7" type="ORF">PNEG_00348</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872221.1">
        <property type="nucleotide sequence ID" value="XM_007874030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PLJ9"/>
    <dbReference type="STRING" id="1069680.M7PLJ9"/>
    <dbReference type="GeneID" id="19894046"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00348"/>
    <dbReference type="eggNOG" id="KOG1076">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004304_0_2_1"/>
    <dbReference type="OMA" id="FRCGLIK"/>
    <dbReference type="OrthoDB" id="29647at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000300">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03002">
        <property type="entry name" value="eIF3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027516">
        <property type="entry name" value="EIF3C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008905">
        <property type="entry name" value="EIF3C_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITATION FACTOR 3, SUBUNIT 8 EIF3S8 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05470">
        <property type="entry name" value="eIF-3c_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="586"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="840" mass="96844" checksum="ECDAADBACEB51E23" modified="2013-05-29" version="1">MSRFYKGGSSNSDSSSSSDNENIYSSGSGLDSDDQGGRDDRSSSDKEIQKKRRTGFQFLKGEDAEDSEEEDSKRVVKSAKDKRTEEFKTSLRNIENAQKINDWVTISSEFEKINKLIERLKVLGKPPRLYIRAIVNLDSFLNETIKKEKEVKKKMNSTNARALNSVKQRIRKSNKLYEGEIKQFLQNPKDNLDEFVEQETLLIDEEFVKDDVVKNKDIQESKDGFSTIGKSNRSLQFTTESILKHLRTVSDSRGKKNTDHAEQIRILEKLLEISVTPYHKIRVLLAMISSKFDYSFGTASYMSIDHWKSAEGDLRSLLELLENDFSYVVLEDAEEYDDDVVPIAKSGEVIKIRGSIVSFVDKLDDELIRSLQNIDPHTTDYIDRLKDETELYSIIYRTQLYLERINAGDSISRIIMRRLEHIYYKPEQVINILEETTWKTIQKSISSKITPYSEKPDAAALIHNLCLYLYKNGTSLPRTRAMLHHIYHHALHDKFYKARDMLFMSHLQDNIFTADIVTQILYNRTMVQIGLSAFRIGMISEAHSALHEICGTGRMKELLAQGLQIQRYNQVSPEQERLERQRQFPFHMHINLELLECVYLTCSMLLEIPSIASSGFSLDTKKVISRSFRRMLDYNERQLFTGPPENSRDCIMQASRALATGDWKKCCELIKSIKIWDLMPESQKIKDILTTKIQEEAVRTYLFTYSPFYETISIPRLSEMFDLPKSNITALVSKMISHEEISAALDQIHNAIIIRKVELSRLQGLALVLIDKIQTFIDQNEKLLEQKSMTIGNEVSKKQNLKGNIQTQTNKDKSTGHVKTNRNLRNDFKNGLGRVIKSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M7PLS6</accession>
    <name>M7PLS6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonucleases P/MRP subunit Pop8-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872315.1">
        <property type="nucleotide sequence ID" value="XM_007874124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PLS6"/>
    <dbReference type="GeneID" id="19894135"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00437"/>
    <dbReference type="HOGENOM" id="CLU_2085790_0_0_1"/>
    <dbReference type="OrthoDB" id="5530243at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034965">
        <property type="term" value="P:intronic box C/D snoRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000294">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, RNase MRP-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020347">
        <property type="entry name" value="Pop8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049128">
        <property type="entry name" value="Pop8-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28173">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28173:SF1">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20976">
        <property type="entry name" value="Pop8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonucleases P/MRP subunit Pop8-like" evidence="1">
        <location>
            <begin position="11"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="117" mass="13995" checksum="66EA5B633960AA19" modified="2013-05-29" version="1">MRPIRMRIFSDFVYFHMKLNESYDDKEIDRKKWQIMIKQALSQGFGLEGESIMIDILHLTKDKCVYIRVPSREESRFWVAMTGYCEKNIQILGVSDHLMGLINRSRLEKNLHEKKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M7PM75</accession>
    <name>M7PM75_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871869.1">
        <property type="nucleotide sequence ID" value="XM_007873678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PM75"/>
    <dbReference type="GeneID" id="19893716"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00018"/>
    <dbReference type="HOGENOM" id="CLU_790153_0_0_1"/>
    <dbReference type="OrthoDB" id="4092340at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="351" mass="39045" checksum="59612D386FC2C3D7" modified="2013-05-29" version="1">MTNNTVTNSDVSNTSEREYASYKGFHNVKNSSFISDATIDASSPNLTPLNTPRSYLLAGLRTAPCLDKQAEHELRSQKNEETYAPFQNVYRKDVYDARQLGVSTYPHMLALSPRTAQGLGLSTYQKASFPVNSVSEPSTPYQHNFDEFRGMTRQKYSPLLFSDSSFTQPILSQQYSCQSRKVKPAPPTASGAFFKGFSPNHISEQHASPYSPMVHESHYGLPSYSSPLELHSLAFSGSASPYFSQNSNLKKNKYFPVFHTNTNGSAVNVNSETGFHGNSAPLNKEGVPYRQPRGPPPMEELLSPNESENKNFSLRLRRQAINKILHAGVQRQNIIFSTESTQDGADDLLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7PMY1</accession>
    <name>M7PMY1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ras-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872104.1">
        <property type="nucleotide sequence ID" value="XM_007873913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PMY1"/>
    <dbReference type="STRING" id="1069680.M7PMY1"/>
    <dbReference type="GeneID" id="19893933"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00235"/>
    <dbReference type="eggNOG" id="KOG2128">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009455_0_0_1"/>
    <dbReference type="OMA" id="AYMITLN"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05132">
        <property type="entry name" value="RasGAP_GAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF17">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="2">
        <location>
            <begin position="149"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR11809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="757" mass="87486" checksum="032FCA3B851972D9" modified="2013-05-29" version="1">MERVSKRYSTVTLYLSMASHENENVDDELSQAQKYLRQLKLRISEQSKKNFILERDVRYIDSRIALLIQNRMALDEQNEMVRHLDDSSELQKGVFPDDRKLQKYGNLFFLLQTEPRHIATLCRLVTLSEIDALLQTVMFTIYGNQYESREEHLLLTMFQSVLSSQFDHTTEFVSLLRSNTPISRMMTTYTRRGPGQSYLKSILSERIKYLYEHNEFNLEINSLKVYDQMIQKIESETGHLPGNLERNVSYETAAANEAVIAIIEPRIAMLMEIADSFLNVIIGSIDIVPYGIRWICKQIRNLTKRKYPDASDYSICSLIGGFFFLRYINPAIVTPHAYMIIDGSPGEHLRRTLTLVAKMLQSLSNKSSYSKEPYMAFLSSFIDLNKPRVNKFLNDLCEVSDFYETLEMDQYVALSKGLFLHITVNEMYGTHSLLEKHLDILAPEPDSHLRILINKLGSAPPLLSRSENRTIELPLYSKWGNFITNLNESLDINRTDILFIEAKSVFVQIIRSFPQNSKIIKLPLNLLLIASTAATFKDALLVRKGIKAIEYLKELSELKLIDPNDFYNPLAEEVEHEIAHLGSLYEEVLRETESLESVYKTIEDHNEYLRGQLEQYKSYLHNVRIHSGRNESKIGVMGGVGVVSLGGKEKKQKKQQVLGPYKYTHFQLEKELVIAESNVPDDRRANIYFTIMSPLPGTFVISLHYKGRDRGLLELNLKLDDLLEMQQSNVQYLDLEYVQFNVSKILQLVNRQFSRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M1FKB3</accession>
    <name>M1FKB3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Cytochrome c oxidase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">cox2</name>
    </gene>
    <organism>
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="19"/>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2013" name="FASEB J." volume="27" first="1962" last="1972">
            <title>Sequencing and characterization of the complete mitochondrial genomes of three Pneumocystis species provide new insights into divergence between human and rodent Pneumocystis.</title>
            <authorList>
                <person name="Ma L"/>
                <person name="Huang DW"/>
                <person name="Cuomo CA"/>
                <person name="Sykes S"/>
                <person name="Fantoni G"/>
                <person name="Das B"/>
                <person name="Sherman BT"/>
                <person name="Yang J"/>
                <person name="Huber C"/>
                <person name="Xia Y"/>
                <person name="Davey E"/>
                <person name="Kutty G"/>
                <person name="Bishop L"/>
                <person name="Sassi M"/>
                <person name="Lempicki RA Kovacs.JA."/>
            </authorList>
            <dbReference type="PubMed" id="23392351"/>
            <dbReference type="DOI" id="10.1096/fj.12-224444"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:11437"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="15">Binds a copper A center.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the cytochrome c oxidase subunit 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JX499144">
        <property type="protein sequence ID" value="AFR90418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_007475008.1">
        <property type="nucleotide sequence ID" value="NC_020332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M1FKB3"/>
    <dbReference type="STRING" id="1069680.M1FKB3"/>
    <dbReference type="GeneID" id="14657957"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13912">
        <property type="entry name" value="CcO_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.90:FF:000004">
        <property type="entry name" value="Cytochrome c oxidase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045187">
        <property type="entry name" value="CcO_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034210">
        <property type="entry name" value="CcO_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001505">
        <property type="entry name" value="Copper_CuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014222">
        <property type="entry name" value="Cyt_c_oxidase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011759">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036257">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02866">
        <property type="entry name" value="CoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 2"/>
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        <property type="entry name" value="CYTOCHROME C OXIDASE, SUBUNIT II"/>
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        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COX2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01166">
        <property type="entry name" value="CYCOXIDASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81464">
        <property type="entry name" value="Cytochrome c oxidase subunit II-like, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50999">
        <property type="entry name" value="COX2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0186">Copper</keyword>
    <keyword evidence="9 15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15 19" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit II transmembrane region profile" evidence="18">
        <location>
            <begin position="11"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit II copper A binding" evidence="17">
        <location>
            <begin position="106"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049512"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AFR90418.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
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    </evidence>
    <sequence length="245" mass="27897" checksum="1EEA3DE716C983DF" modified="2013-05-01" version="1">MINNNIIHNDAPTPWGMTFQDGASPVFDGIVELHDQVLFYLLIILVGVSWILLSTILRFKDSPIIHKYHNHSTTIELIWTVSPAFLLIAIAFPSFKLLYLMDEVIDPAMTIKAIGHQWYWSYEYSDYVDKEGHSIEFDSYMLPAEDLEEGQLRQLEVDSRVIVPVNTHLRWIITATDVLHDFAVPSLGIKVDASPGRLNQISTFIQREGVYYGQCSELCGVLHSSMPIVIEAVSLEKFLSWLDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M1FNZ7</accession>
    <name>M1FNZ7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Cytochrome c oxidase subunit 1</fullName>
            <ecNumber evidence="5 18">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">cox1</name>
    </gene>
    <organism>
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="21"/>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2013" name="FASEB J." volume="27" first="1962" last="1972">
            <title>Sequencing and characterization of the complete mitochondrial genomes of three Pneumocystis species provide new insights into divergence between human and rodent Pneumocystis.</title>
            <authorList>
                <person name="Ma L"/>
                <person name="Huang DW"/>
                <person name="Cuomo CA"/>
                <person name="Sykes S"/>
                <person name="Fantoni G"/>
                <person name="Das B"/>
                <person name="Sherman BT"/>
                <person name="Yang J"/>
                <person name="Huber C"/>
                <person name="Xia Y"/>
                <person name="Davey E"/>
                <person name="Kutty G"/>
                <person name="Bishop L"/>
                <person name="Sassi M"/>
                <person name="Lempicki RA Kovacs.JA."/>
            </authorList>
            <dbReference type="PubMed" id="23392351"/>
            <dbReference type="DOI" id="10.1096/fj.12-224444"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Mitochondrion inner membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="5 18"/>
    <dbReference type="EMBL" id="JX499144">
        <property type="protein sequence ID" value="AFR90422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_007475012.1">
        <property type="nucleotide sequence ID" value="NC_020332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M1FNZ7"/>
    <dbReference type="STRING" id="1069680.M1FNZ7"/>
    <dbReference type="GeneID" id="14657961"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01663">
        <property type="entry name" value="Cyt_c_Oxidase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.210.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="entry name" value="Cytochrome c oxidase-like, subunit I domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033944">
        <property type="entry name" value="Cyt_c_oxase_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014241">
        <property type="entry name" value="Cyt_c_oxidase_su1_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02891">
        <property type="entry name" value="CtaD_CoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422:SF18">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="Cytochrome c oxidase subunit I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 18" id="KW-0186">Copper</keyword>
    <keyword evidence="13 18" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 18" id="KW-0349">Heme</keyword>
    <keyword evidence="15 18" id="KW-0408">Iron</keyword>
    <keyword evidence="17 18 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18 21" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 18" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="10 18 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="182"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit I profile" evidence="20">
        <location>
            <begin position="1"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012949"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00015947"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="AFR90422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="527" mass="58443" checksum="E2FA82FBA2D507E3" modified="2013-05-01" version="1">MISRWLFSTNAKDIGVLYLMFALFSGMLGTAYSVLIRMELASPGIQYLQGDNQLYNVLVTSHALLMIFFMVMPGMVGGFGNWLVPIMIGSPDMAFPRLNNISFWLLPPSLILLIFSSLVEGGSGTGWTFYPPLSGIGSHSSGAVDLSIFSLHLAGISSMLGAINFITTILNTRAPGMTMHKLPLFVWSIFVTAILLLLSLPVLAGAITMLLTDRNFNTSFYEVSGGGDPLLYQHLFWFFGHPEVYILIIPGFGIISHIISTFSGKPIFGYLGMVYAMLSIGVLGFLVWSHHMYTVGLDVDTRAYFTAATMIIGIPTGIKIFSWIATMYGGSLRFTTPMLFAVGFLFLFTIGGLTGIVLSNASLDIAFHDTYYVVAHFHYVLSMGAVFALIAGWYFWSPKILGLSYKEELGHIHFWTLFIGVNLTFMPMHFLGLQGMPRRIPDYPDAFAGWNFVSSFGSFVSILATVLFIYSIYHQLVFGQPVAPNPWYSPPFFISHSHPVEDRNTSLEWAIQSPPAFHHFTILPKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NI32</accession>
    <name>M7NI32_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_03387</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875471.1">
        <property type="nucleotide sequence ID" value="XM_007877280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NI32"/>
    <dbReference type="STRING" id="1069680.M7NI32"/>
    <dbReference type="GeneID" id="19897074"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03387"/>
    <dbReference type="eggNOG" id="KOG2394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016971_1_1_1"/>
    <dbReference type="OMA" id="MCVCWSP"/>
    <dbReference type="OrthoDB" id="3367at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045013">
        <property type="term" value="P:carbon catabolite repression of transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051362">
        <property type="entry name" value="WD_repeat_creC_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107:SF16">
        <property type="entry name" value="AT02583P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="405"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="573" mass="65647" checksum="88470C9CDCF7F3F9" modified="2013-05-29" version="1">MDTAESLSGQEHQFSLEEGVYDLRKQFFLNSIPYSLENVNTDPLSIDIKPITNKMEISIVDIRQDKYPSQMKPLFEDKNLSIKDELSLDQTNDSMSSVSPNGTDLIKDISLESKNMNEYGPFPTNLFSNRISFAGNVPETSKENNTMKSHYPLHLKNTNVPVKKLKPKNSILKASSSFISRIILHDDMTKCLASKTSDIIYIFSNVEKVFNWIGIFSEVKEEFISKIIFSKAYITCHDANQYTRSINQIDTVFGFSTSDIIWFDPISTKYTHLNKQGVINSSPINCIKWIPGTEDLFMAAHNDGSLIIYNKEKEKCFFVQNESFIEKSDSYEFKVLKSLSDTENQRYNPISYWQLYKHSPTSLSFSPVSCHVAVAFSNGTLKLIDYKNEKHIDTYHSWYGGLICVCWSPDGQYILTGGEDDLVTIWSFLDRRIVYRCQGHQSWVTGVAFDPWRCNKNHYRFGSVGEDGRLLLWEFNADTFNKSKDFNQTNGYFPLKNNYKSIKTPQDTETQKKSLHISSEPFDHAPMSQASVSILSPIMSKILSDQSLTGLIFCQNFIAISGKKNFIQIWDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NIH9</accession>
    <name>M7NIH9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_03223</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875286.1">
        <property type="nucleotide sequence ID" value="XM_007877095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NIH9"/>
    <dbReference type="STRING" id="1069680.M7NIH9"/>
    <dbReference type="GeneID" id="19896910"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03223"/>
    <dbReference type="eggNOG" id="KOG0292">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007565_1_0_1"/>
    <dbReference type="OMA" id="EMTYQKQ"/>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22948">
        <property type="entry name" value="Coatomer_WDAD_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000002">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000010">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047312">
        <property type="entry name" value="Coatomer_alpha_WD-assoc_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016391">
        <property type="entry name" value="Coatomer_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010714">
        <property type="entry name" value="Coatomer_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF1">
        <property type="entry name" value="COATOMER SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06957">
        <property type="entry name" value="COPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003354">
        <property type="entry name" value="Coatomer_alpha_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="7"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="49"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="91"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="133"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="204"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="248"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="12">
        <location>
            <begin position="343"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="14">
        <location>
            <begin position="643"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer alpha subunit C-terminal" evidence="13">
        <location>
            <begin position="859"/>
            <end position="1214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR003354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR08383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1220" mass="139732" checksum="CCAB8B77F8588F4D" modified="2013-05-29" version="1">MQIFTKFESKSSRVKGVAFHPKRPWILTSLHNGTIQLWDYRMGTLIDRFDEHDGPVRGISFHSTQPLFVSGGDDYKIRVWNYKSRKLFFTLNGHLDYVRTVFFHHEYPWILSSSDDQTVRIWNWQSRNSIAILTGHNHYVMCAQFHPKEDFVVSASLDQTIRVWDISGLHKKNTIINFENQSNKSHNQSSDIFGNNAVVVKYVLEGHDRGVNWVCFHPTLPLIVSAGDDRLIKLWRMSDTKAWEVDTCRGHFNNVSSVIFHPHQDLILSVGEDKSIRIWDLNKRTSLHSFRRDNDRFWIIAAHPEINLFVAGHDNGVMIFKLERERPAYTIYQNTLFFINKEKYICSYDLKQNAGESSIISFQKLGSRWKKPRTISYNPAQRMILACSPVDNGSYEIFHLKSNETNSLNFTGTKKDSSFTSEDENSEKLSGSASSAIFISRNRFAIFDKSRQTIEIKDLLNTTIKTIQLLVIIDDIFPAGNRNIIISSSSSVILYDIQQKSIITQLSIPQVKYVVWSSDGEHVALLGKHTITIATKLLKQVCSLHETMRIKSACWNDSSVLIYSTLNHIKYALLNGDNGIIRTINHPIYLVQVKDKTVCSLDCDSKLDFVNIDTTEYHFKLSLINKSYNEMLHIIRTSNLVGQSIINYVQEKGYPEIALQFVQDPQTRFELSLKCTNIKLALNIAKKIDKPEVWTSLATEALLQGNHQIAEISYQKLKNFSKLSMLYLITGNTAKMEKMLKIAKNRGDYTNRFHNTLFLGDVESRIQMFKEIDQYALAYATAKTYGLMDHCSSILKEAGVLESDIKIPSGIALLPPKPLYNTFEANWPLKPMTQTWIEKALFNQLDLMTIEDEYSQYDNVDTATNLNKSNVEQNQKNTVTEDLDEGWNIDDDIVSNADIQISEDIKTEIDISSGIKETDLWIRNSPLAADHIAAGSFETAIQLLNRQIAAVNLKPLKPKFMMIFQVSRVFLLASPSLPSLYYYLRRTKETDSKKPLPYIPLNLNMTRKLLENAYQFVKANKLPEAINIFRDILYNLLLTVISTESEEEEITQLIEMSQQYIVGLSMELKRRELPAESVELNLELAVYFTHIALQPSHKQLALRQAMNLLYKNKNLYSASHFATRLLELNPSSQIVEQAQKILAIGDRSPKDAIKINYDPFTDFDICAKSYTPIYKGNLKEICPFCGAKYLLKYKKTLCVICKISSIGASATGRRNRISTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NIZ5</accession>
    <name>M7NIZ5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar import and degradation protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_03054</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875110.1">
        <property type="nucleotide sequence ID" value="XM_007876919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NIZ5"/>
    <dbReference type="STRING" id="1069680.M7NIZ5"/>
    <dbReference type="GeneID" id="19896741"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03054"/>
    <dbReference type="eggNOG" id="KOG2395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007002_0_0_1"/>
    <dbReference type="OMA" id="RLNETKW"/>
    <dbReference type="OrthoDB" id="10251113at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040458">
        <property type="entry name" value="Vid27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013863">
        <property type="entry name" value="VID27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040979">
        <property type="entry name" value="Vid27_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040768">
        <property type="entry name" value="Vid27_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913:SF0">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08553">
        <property type="entry name" value="VID27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17748">
        <property type="entry name" value="VID27_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17747">
        <property type="entry name" value="VID27_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vid27 N-terminal" evidence="4">
        <location>
            <begin position="9"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Vid27 PH-like" evidence="3">
        <location>
            <begin position="198"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar import/degradation Vid27 C-terminal" evidence="2">
        <location>
            <begin position="372"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="735" mass="84942" checksum="222260B848C458D0" modified="2013-05-29" version="1">MSHLFFMNYIPVGQLYLVRPSSPKGRRECIYKDAAANIKRTFTEFHYQLVIQRAYEEGEEQILNEDEQEDEKSFLLDESLKFHSFVRENCVVYAWSDLSGDEQDLYEFVCDSTIQSNILHMFEEVALRCMFERKYRRSHEEATNEDLSQFLTSKSTFSSFRNPSLVQSPLVSSKVKGDQETCHLKDKTQEPVDNSIKIMVQVSAELHLFDAADNVFILQDSNVVATVSEIDTWEYWLEIKSSERTWLGQPIHPDINPVFNYEHLSFIWNYCDDRSQIYSWLLRFSNIEVEERFQEGFMIALWEMLNQQKWIKIKDDDKEYIIDVFHQDVKMEDVNNDNTEEDDEEDIDSDTNDIPEDQENEFSSMSEDNKGENSQLAVGYKHDRSFVVRGDKIGVFRHMDDDRLEFVAAINKVQTPKGKQFQPSRIMLHNEDSEIILQNPNEPHNLYQMDLEYGKVVDEWKIDDDISVLNFTPESKFAQMTTEKTLIGISHNSLFRIDPRLPKNKIVKSEHKQYATKNDFTVAATTEKGYIAVASNKGDIRLFDRIGVNAKTALPALGEPIIGIDISADGKWVLATCKSYILLIDCTIKEGKNQGKLGFEKSFEKETKPKPKRLQLNPVHVAMMQGQINFTPAKFNTGMGVEEKTIVTSSGPYVISWELSKVVKGETGKYKIRQYTDEVKADNFKFGTDQNVIVALPHDVSMVNKYTFKKPSRKSLLRTPIKDLQSRSSIVNSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJ66</accession>
    <name>M7NJ66_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleoporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02844</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874879.1">
        <property type="nucleotide sequence ID" value="XM_007876688.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NJ66"/>
    <dbReference type="GeneID" id="19896531"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02844"/>
    <dbReference type="eggNOG" id="KOG1835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002778_0_0_1"/>
    <dbReference type="OMA" id="WSQMFAE"/>
    <dbReference type="OrthoDB" id="2019644at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1674" mass="195099" checksum="A52ED6A2EB5434F8" modified="2013-05-29" version="1">MLLETWDPDNYKLLYDTLLNLSEGTVIPESFLEHLLKPFHQDFKNLLQTPKKSEQSLEKLKSGIIYIDGTKYKLNDTFISEALHVSNKLNLDEVLSAKLVHYGIKNSKNLDRSILQTSLFLFYSRRKFLLNSLSMILLYAKNDLGNREILKYFKQTVQFIFQKNSENPKENLPTYPMKCLQAMEDLRTQISNIFYQKKNKNFNEYSQNDEYIEEIKLRKESMLQEHEIYGVLLYRLSNLNMVNIDDFEKIIHRISLFDEYDLLITHFFPVIINFIALGGEISSQNENELENFTYYDIEILRKINKIINSDYQNEKKWGIGPLKSIIQLWWTTKLNRVCKKELDISVPFKYSSDIYNPSKEAISSGAFETMIKKIIDVLRFETKNLLRLEDYKLLLNYPKFKEGMDFPELTFSKAFQEIMLYEIEKFIYSFISDMPDLLKNMKLVEEDLIMTQKSLDFDADDKIESSLEAFFYLIALVYENRKDSALSFWLDRESDLYGFILWSSQCQTPLMITAFSTMLASLGNGPQCSTYAYDFLTETKGTETMKAQNNMTTWEYIFDTLKYYVSQLKITHFDSSLSSSRMLTVAIDFLEIDHDSRSILRSYFHLITCILSSCPYVSNMVYKKYNPIPILFDLLNCQLSSDMYCGILLTLTSFLSGKELEIRDTVWNLLDQWIYQQNNEIYLAHTSYTVPNKFNESLKSYTKIDQTLRVFVSNSLSLAIAFVLLLNHLIISIDDLNNILPFPESIGLNRKDPGIQPFIDLVMDLFLTSNSLILDNKLGGLQLFSECLKFIQLGLKTFNLDIAEIASLNSIEMNKFIKTSSFSSYLNLHPGNRIMQHMYRNNIYICLFDFIHIALEVLQNTESDPLWLLCLDTSLNILDLVLHLQLPFLEWFSSIATYQSTYISSNNHNKPNFEAFEDIMLFHLNVIVYICLCIGFDSLDISKTAVSILKKLSDSPQLTDTKNYKHFNNFKRNRLLGILETVDESKRIRFGAINLIQTEQNRFLNTSHLDQDTSGRIFLKFLAWDLQKNQNIPTVSHFFLGFQMLNDGTSDIGTEKGEIGSEISILHCLLSFIQNSSSMEETLLDSPKNNLSNTIMETVMHIIFLLSKSELTSDIMYDILKKRDDILLKLLFPGPLTWILPKLDSSNLNTFSLKPVKILLYRSWLLHTIAIKLRKMIIYNATTLQQCYTKALTFYDEGNKNDQNDYLQSLNKGIRILKYLDILELDIITDDQEFILEKTQQMFSNIPRSSNSLYDIKKIKTYMKLKACEFQNKDFGSKRKTFTIVEKDIISQIEISNILIEINNAKLLCFQGWNNLLGILLEDCTVHLTQSQKDSLIIESLRILTSKLTNFSKKDENIIEICSSSVLILIRHITKNTVFEEKYFLFLKNILLGIQNPNTNETIRQNLYVAVIFYLNIISGLKFQSNQSHKLFESYTNIFKEKKNSQIIKPYYNQLIHVICRDAIYGSGMSKMLSYLILNLTGKIDTIIFFGPLWDTLIHQNYLHIFITSLWECEELNALIFTEFDNSLEGTIIEAKLNFILRVSQTKIGAQEILKNELFDYLIDKKDFIQNNLNNIRSIFHPTKKDHQNILNRRMHLICILLRILISCMISLGLKNAIAHNVGEKFYTAYREIIVFFKENYSKHQIENSEMTEILKITNTLEIILENYKPLIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJB0</accession>
    <name>M7NJB0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Association with the SNF1 complex (ASC) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02881</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874918.1">
        <property type="nucleotide sequence ID" value="XM_007876727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJB0"/>
    <dbReference type="STRING" id="1069680.M7NJB0"/>
    <dbReference type="GeneID" id="19896568"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02881"/>
    <dbReference type="eggNOG" id="KOG1616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070949_2_1_1"/>
    <dbReference type="OMA" id="HEYKFMV"/>
    <dbReference type="OrthoDB" id="531008at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900735">
        <property type="term" value="P:positive regulation of flocculation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000562">
        <property type="entry name" value="Snf1 kinase complex beta-subunit Gal83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006828">
        <property type="entry name" value="ASC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF84">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04739">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01010">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160219">
        <property type="entry name" value="AMPKBI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Association with the SNF1 complex (ASC)" evidence="5">
        <location>
            <begin position="209"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="311" mass="35023" checksum="ABB61DF038BB73EF" modified="2013-05-29" version="1">MGNSYSQENLNDAKDPLLYSLSDKNEGLGDGLFKKDIIPQKNPSSDVEDDFSSVNSETDKEPLNLDSLNDLNKTTIEDERHNVQDSSIISPTCENIEHDVKQQNREKSVPVFLHWKGNHQNVYVTGTFTGWGKKIPLNKSVNDFTALIHLPKGTHRFKFLVDNEWKCSDELATATDSSGNLVNYIEVNDASLSSMFQADKQASLTEHRVSKPVETYTNRIPTLYDEALENNTYRNFQESSVPPSLPPHLEKVILNSNSTMKDDQSVLPNPNHVVLNHLAASSIRNGVFAVSVTTRFRHKYVTTILYKSINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJE1</accession>
    <name>M7NJE1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lysophospholipid acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02903</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874943.1">
        <property type="nucleotide sequence ID" value="XM_007876752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJE1"/>
    <dbReference type="STRING" id="1069680.M7NJE1"/>
    <dbReference type="GeneID" id="19896590"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02903"/>
    <dbReference type="eggNOG" id="KOG2704">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011340_5_0_1"/>
    <dbReference type="OMA" id="WHGTRPG"/>
    <dbReference type="OrthoDB" id="286734at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071618">
        <property type="term" value="F:lysophosphatidylethanolamine acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036151">
        <property type="term" value="P:phosphatidylcholine acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090640">
        <property type="term" value="P:phosphatidylcholine biosynthesis from sn-glycero-3-phosphocholine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF4">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="58092" checksum="097027BBA397EE64" modified="2013-05-29" version="1">MAMDTGLLTAITLGVVLIRYPVDLPLWIDWLIGTIAEVIGISIDNFKLLGCLIFSYPSACFLRKLPSKKPYFKNIFNIIISVFFLIVFNFWYALQTVLISATGTYIIVKYIKGKYMPLIAFIFLIGHLSVNHFCRQFFNLDPGMDVTSIQMVLCMKLTAFAWNVYDGRQDLLTLTQKQRKYCLKELPSLLDYLGYIFFFPSFIVGPSFDMADYYHWLTNGTSTYVPKKKHADKLKKRLLRKDRYYALKKFVSGLFYLCLFQLMSLYFSTAFVLNDEFLETTRIYRFLYLIPLSITHRLKYYGVWSIAEGACILSGIGDVTRNHNGDIIHNSLENINPYDVEMAQNTKQLFEAWNKSANRWLKYYVYLRVISYNDNAKFKGSFVTFMVSALWHGFYPGYYLSFITGAFVQILGKYFRKHIRPLFLTKDMKPTRYKIFYDVLSLLTMQLTWGYIAQPFVILGLWDSLRFWQRYDFFVHFGILVLFLLFLSPLKALVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7NKT0</accession>
    <name>M7NKT0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Early meiotic induction protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_02582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874597.1">
        <property type="nucleotide sequence ID" value="XM_007876406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NKT0"/>
    <dbReference type="STRING" id="1069680.M7NKT0"/>
    <dbReference type="GeneID" id="19896274"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02582"/>
    <dbReference type="eggNOG" id="ENOG502S9DM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2147325_0_0_1"/>
    <dbReference type="OMA" id="QMAMCLT"/>
    <dbReference type="OrthoDB" id="2017405at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021475">
        <property type="entry name" value="Pants/Emi1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052:SF1">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11326">
        <property type="entry name" value="PANTS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR09248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="14166" checksum="9256596A93F2504E" modified="2013-05-29" version="1">MFDENVINKENNKYFDNNSLNLNENLNEKLEEPCSLQYYFDSFFMCYTLKNQFVHYYRYGQRPDCSSKWRDFLWCLRSKSQSKELEQKMLLEKRLEKLEMLKKGRNSEEIWSSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NL97</accession>
    <name>M7NL97_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription initiation factor TFIID subunit 1 histone acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874386.1">
        <property type="nucleotide sequence ID" value="XM_007876195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NL97"/>
    <dbReference type="STRING" id="1069680.M7NL97"/>
    <dbReference type="GeneID" id="19896073"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02380"/>
    <dbReference type="eggNOG" id="KOG0008">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000572_1_1_1"/>
    <dbReference type="OMA" id="KEFMKYQ"/>
    <dbReference type="OrthoDB" id="5752at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 1 histone acetyltransferase" evidence="4">
        <location>
            <begin position="326"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="979" mass="112986" checksum="9A8AB0FB7564A443" modified="2013-05-29" version="1">MGRPPKSKNIRSSLSSDDDQRVSIEPCFTEELETEAFEERWMDDLDLLDNDLPEDVVTSESKKDDSNELESILREGYVPSGCGEGEAEMIPIQLLRLGWGSLQEFDPSLSGSKTIEKHSREAILKKYFPEFQENEVLKFCELFISKKAFFVPVKHKMTRTCFPSWVRLDVEQDDSQAFASFDRSIRPRWDDEVIFISSFSEEVNEEIKLDKESSDVFHSSSSNEMNHDLHLTCFDWYRKVFSDEFSPSKNVTLVRSNSKIKFMGEGFLSQLQIDDRIFNGNVELASPVQLNFNDPFLLLDIQRANSDCYKHLTNDHFLYNDLSRRYNISNDEAYDLLRQNQQSRVRQTLGHLSIEHGLVADRLQSPYYKTRLSKTECRLFHRPVITFKIDHEIKFSKIGLRKKKKDRIKDPKILLNTTKDITLSDNSTYVLMEYSEEYPSVISNPGMASKVVVFYRKKSNEDYTRPKMTIGETHILEPQDRSPFWNFGTVDPGETVLTLYNKMIRAPIFAHEPQSTDFLVIRNTCSQGSRYYLRNIKYLYVIGQTFPVVDVPGPHSRKITMVSKNRLKMICFRLLRREESGKILIKQMAHHFPDQNEMQLRQRLKEFMDFQRKGDDQGYWRLKSSEVLPSEVVIRNMVSPEMVCLIESMQVGLQNLEDAGYGRAVEDENMDETCLSIDQQLVPWILTRNFINATQGRAMLKLHGEGDPTGCGQGFSFIRTSMKGGFKSLDETMDEKTDGDKSKTSHGYNIAKQSKAYEDEIARIWKSQRIGLSMTGDSTTSDSEYVDSQKESFNDNKMDGGWYVSTPQSADLIENDNYVSMNSQMGSGQINKVLRIQRFTRNSSGQLERKVEIVHNINVIRAYIRHRQLIDDEATMMEKMGPTDDDDVNRRRKKLLEEQLTRLKHNHERRQARKAAKAAQKAEASVLYETSLPNIKKNTSSTNRRCGNCGQVGHMKTWRGCSMHGNAVYNTSGLSDDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLC0</accession>
    <name>M7NLC0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PNEG_02405</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. COT1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874411.1">
        <property type="nucleotide sequence ID" value="XM_007876220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLC0"/>
    <dbReference type="STRING" id="1069680.M7NLC0"/>
    <dbReference type="GeneID" id="19896098"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02405"/>
    <dbReference type="eggNOG" id="KOG0605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_67_4_1"/>
    <dbReference type="OMA" id="FKGYTYR"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21742">
        <property type="entry name" value="MobB_NDR_LATS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05573">
        <property type="entry name" value="STKc_ROCK_NDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000192">
        <property type="entry name" value="Serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059233">
        <property type="entry name" value="MobB_NdrA/B/Cbk1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF400">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="14">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="225"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="15">
        <location>
            <begin position="568"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMR09463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="658" mass="76540" checksum="077091AC6E06A389" modified="2013-05-29" version="1">MKNLKKKTIRTHKPGTKKDGLFGTFFLELISFFFPKHNGSNKNVCISSPVDFRHLAHANNKKEAIAIYEKFSFNVFDESKKNTTMSILLDSENKSVQENELLPPLKMGQTPFIHSTSETLIVPSESTVIYRNNKKKALYLRNILFQQPSLSTIEKSAATKIFFETYFHNIFKKPNPREERRKNLEIQLKNPKLSDRERESLRLKFNREETEYLRSLRQRVDASSFVILKTIGHGAFGVVKLVRKKDNGMIYAMKILKKADMLKKGQEGHVRAERDLLAIASDNGSWTVKLCYSFQDLAHLYLVMEYMPGGDLLNLLIVKDVFPEEFARFYIAEMVLCIEEIHKLGYIHRDIKPDNFLFDRHGHIKISDFGLSTDLSWLHDSAYFEHQRVYLLKKSGINIGNSISKRKGLNILTMLELHEDKDTGDGILSWNDENRREFAYSLVGTNSYMAPEIIRGEGYTKSCDWWSLGVILFECLYGFPPFVSKTKHATRMKILNWRQALHFPTTPSVSKEAQDLIKKLICDHKDRLGSNLCKIYPNSLNTISEYSASKTYHYCSDADEIKTHSWFRNIDWNSLHKQIPPFIPKIKNLEDTKYFEELNKDEVLQSTLDISHDKIRDSLLRDKIYGEQILQIRKKLAFKGYTYRRKHIPINTQSITCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLI1</accession>
    <name>M7NLI1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02109</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874091.1">
        <property type="nucleotide sequence ID" value="XM_007875900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLI1"/>
    <dbReference type="STRING" id="1069680.M7NLI1"/>
    <dbReference type="GeneID" id="19895803"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02109"/>
    <dbReference type="eggNOG" id="KOG2620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024949_1_0_1"/>
    <dbReference type="OMA" id="YLQMLPK"/>
    <dbReference type="OrthoDB" id="434619at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08829">
        <property type="entry name" value="SPFH_paraslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000008">
        <property type="entry name" value="Stomatin-like protein 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050710">
        <property type="entry name" value="Band7/mec-2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032435">
        <property type="entry name" value="STML2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF10">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16200">
        <property type="entry name" value="Band_7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="31"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="322"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="350" mass="39012" checksum="DEFC024B0E432003" modified="2013-05-29" version="1">MNIRGYSDIPKRKFNQTSLNLFKRQKLPKNTIIKFVPQQEAWIIERMGKFYRILDPGLAILVPFLDKIKYVKSLKEIAMEIPSQSAITLDNVTLELDGVLYVKILDPYKACYGVEDAEYAVAQLAQTTMRSEIGQLALDHVLKERQMLNINITEAINEAAEDWGIKCLRYEIRDIHPPQNVLLAMHRQVSAERSKRAEILESEGQRQSCINIAEGQKQSQILNSEAIKQESINKATGEAEAILLKAEATAKGISAIASVLSENPMGTDAINLRIAEKYLTAFGNIAKESTSIVVPANLNDINGMVAQALTIINKLNQNIPQKKEIKSPISKTTHSLKSPTSSNELKEKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NM08</accession>
    <name>M7NM08_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PNEG_03400</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Microsome membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 14">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875485.1">
        <property type="nucleotide sequence ID" value="XM_007877294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NM08"/>
    <dbReference type="STRING" id="1069680.M7NM08"/>
    <dbReference type="GeneID" id="19897087"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03400"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102602_3_2_1"/>
    <dbReference type="OMA" id="YRDQFFI"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF150">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 14" id="KW-0349">Heme</keyword>
    <keyword evidence="9 14" id="KW-0408">Iron</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="15">
        <location>
            <begin position="10"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMR08232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="130" mass="14741" checksum="A325F789EC9520BB" modified="2013-05-29" version="1">MVENIEINTLRKIEASEVAKHVTRDDIYMVIDKMVYNVSPFINEHPGGEEVLLDVAGKDATDAFEDVGHSDEARDILKKLVVGKLEGKMEESELRVKPDLSVSRNNFNLKLCIITVSVSVFSFLMYMFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M7NM30</accession>
    <name>M7NM30_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01908</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873884.1">
        <property type="nucleotide sequence ID" value="XM_007875693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NM30"/>
    <dbReference type="STRING" id="1069680.M7NM30"/>
    <dbReference type="GeneID" id="19895602"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01908"/>
    <dbReference type="eggNOG" id="KOG0175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_7_1_1"/>
    <dbReference type="OMA" id="NLGMAMQ"/>
    <dbReference type="OrthoDB" id="37597at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080129">
        <property type="term" value="P:proteasome core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03761">
        <property type="entry name" value="proteasome_beta_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF3">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="265" mass="29614" checksum="E008604443F043BA" modified="2013-05-29" version="1">MEKILKSFSKDEIETYDSKESVYKKRIPYNILKEKYLSVSEVTSKITHGTTTLSFRFSEGIIVAVDSRATAGSWIASQTVHKVIHINNHLLGTMAGGAADCQFWETVLSMECRLYELRNKTQISAEVSSKILANILYSYKGMGLSVGTMICGLDSKRGTSIFYLDSEGTRLKGNLFCVGSGQTFAYSILDAEYHWNLQKDQAIYLAKRAILASTHRDSYSGGFINIYYINADGYEFCGGFDVGKLFYDTIKTDNSFQHVIQASTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMC3</accession>
    <name>M7NMC3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase II subunit 1</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">ATP-dependent DNA helicase II subunit Ku70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PNEG_03202</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ku70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875265.1">
        <property type="nucleotide sequence ID" value="XM_007877074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMC3"/>
    <dbReference type="STRING" id="1069680.M7NMC3"/>
    <dbReference type="GeneID" id="19896889"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03202"/>
    <dbReference type="eggNOG" id="KOG2327">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014815_3_0_1"/>
    <dbReference type="OMA" id="FWANVKH"/>
    <dbReference type="OrthoDB" id="3249161at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00788">
        <property type="entry name" value="KU70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.970.10">
        <property type="entry name" value="Ku70, bridge and pillars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006165">
        <property type="entry name" value="Ku70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027388">
        <property type="entry name" value="Ku70_bridge/pillars_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047087">
        <property type="entry name" value="KU70_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005160">
        <property type="entry name" value="Ku_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF2">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03730">
        <property type="entry name" value="Ku_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003033">
        <property type="entry name" value="Ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Ku" evidence="18">
        <location>
            <begin position="303"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMR08362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="548" mass="63879" checksum="E151C188B490D1C3" modified="2013-05-29" version="1">MDFEDNLRKDDNIEKPEKKNHEDYYIDEALLFLIDVSLLPESDEEVSIIAKTALIAAYKMLIYRVISKPTISFGILLYGTKDTNIQEFPLYSNLYLILNLDVQSGSSIRNFKILLSDDTKVSKIIIPTTKHIKLFNALEYANNMFSQLNSSYKLKRIFLITHNDDPSLGSQEYKDATIASFKNLSNSGITIEPFFINGKKMFNFDKFYKDVLYISKNADKIEHHLTYEMLDLDQMVNTILRRQSPKRFLFECSLQIAPNLDIDVRGYILFRKRAPLKTYNVYIKTEEPQIVKTVVNYVCQETSAPLKNEDIKMAYDFGGKKILFSEEQMTILRFYEDPIIRILGFKSLDQLNFWENVLPSYFLYPIDKKNPDSSNLFASLARTLYKLNKIAIAWFRPYKNSNPRICALVSNFNFDKKYDNYEFPKGLFAIILPFLDDIRQNPEQDSVKAPDALIDKMSEIIEHLMIHSYNPLHYENPGMQWTYKKLSSIVLGEDPSADIIDKTIPNYHLINKKAGSFILQWNQLLANLNESHETTSYPFKRQRIETDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMD0</accession>
    <name>M7NMD0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Outer kinetochore protein DAD4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PNEG_02004</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873984.1">
        <property type="nucleotide sequence ID" value="XM_007875793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMD0"/>
    <dbReference type="STRING" id="1069680.M7NMD0"/>
    <dbReference type="GeneID" id="19895698"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02004"/>
    <dbReference type="eggNOG" id="ENOG502S890">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177920_1_1_1"/>
    <dbReference type="OMA" id="SQMWANY"/>
    <dbReference type="OrthoDB" id="5516652at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013959">
        <property type="entry name" value="DASH_Dad4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08650">
        <property type="entry name" value="DASH_Dad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMR09823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="72" mass="8489" checksum="DC6C1A1AE73B510C" modified="2013-05-29" version="1">MENPHEEQQNALMARIVTNVEKLNEAIMEFNRCIQEINMANMNLELISQMWANYGRNVRFHLEGTNNLEKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMM1</accession>
    <name>M7NMM1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">60S ribosomal protein L12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_03300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="function">
        <text evidence="5">This protein binds directly to 26S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875375.1">
        <property type="nucleotide sequence ID" value="XM_007877184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMM1"/>
    <dbReference type="STRING" id="1069680.M7NMM1"/>
    <dbReference type="GeneID" id="19896987"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03300"/>
    <dbReference type="eggNOG" id="KOG0886">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074237_5_0_1"/>
    <dbReference type="OMA" id="QPPHDVI"/>
    <dbReference type="OrthoDB" id="1478556at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="8">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="7">
        <location>
            <begin position="74"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00058826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="165" mass="17884" checksum="3AB23ED5DFFFAB46" modified="2013-05-29" version="1">MAPKFDPNEIKIIYLRVAGGEVGASSTLAPKIGPLGLSPKKVGEDIAKATGGWKGLRVTVKLTIQNRQAQVEIVPSASALIIKALREPPRDRKKEKNIKHSGNITLDDVVNIARQMRFKSLAKELSGTVKEILGTAYTIGCHVDGRNPKEIIDEIISGDIQIPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMM7</accession>
    <name>M7NMM7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_01692</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873655.1">
        <property type="nucleotide sequence ID" value="XM_007875464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMM7"/>
    <dbReference type="STRING" id="1069680.M7NMM7"/>
    <dbReference type="GeneID" id="19895386"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01692"/>
    <dbReference type="eggNOG" id="KOG0469">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_11_2_1"/>
    <dbReference type="OMA" id="ASWNTEN"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03700">
        <property type="entry name" value="EF2_snRNP_like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000010">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000006">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000003">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000058">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF10">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="17"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR09933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="842" mass="93598" checksum="6F31AC64B8BC9C7A" modified="2013-05-29" version="1">MVNFTIDQIRMLMNRPCNIRNMSVIAHVDHGKSTLTDSLVQKAGIISAASAGNARFTDTRPDEQERGVTIKSTAISLYAELDHESVKDVPYKTDSNEFLVNLIDSPGHVDFSSEVTAALRVTDGALVVVDCVEGVCVQTETVLRQALAERIKPVVIINKVDRALLELQISKEDLYQSFSRTIESVNVIISTYFDKAIGDVQVYPDKGTVAFGSGLHGWAFTVRQFAVRYSKKFGVDKSRMMERLWGDNFFNPKTKKWTKCATDADGKPLERAFNQFVLDPIFRIFSAVMNFKKDEVISLLQKLDITLNSEEREQEGKALLKTVMRKFLPAADALLEMIVIHLPSPEIAQKYRCETLYEGPQDDECAVGIKACDPKAPLMIYVSKMVPTSDKGRFYAFGRVFSGTVRAGLKVRIQGPNYIHGKKDDLFVKNIQRTVLMMGRYVEAIEDCPAGNIVGLVGVDQFLLKSGTLTTSETAYNLKVMKFSVSPVVQVAVDVKNANDLPKLVEGLKRLSKSDPCVVCYTSESGEHIVAGAGELHLEICLKDLEEDHACIPLKKMPPVVSYRETVTSVSSMIALSKSPNKHNRIFMTAEPITEDLSLAIESGKVSARDDFKVRARIMVDEYGWDLTDARKIWCFGPETVGPNMIVDQTKSIAYLSEIKDSVVGAFQWATKEGPLAEENMRSCRFNILDVVLHADAIHRGGGQIIPTARRVVYASALLASPCLQEPVFLTEIQCPEQAMGGIYGVLNRRRGHVFSEEQRPGTPLFNIKAYLPVLESFGFTAELRQATGGQAFPQTVFDHWDTMSGSPLDATSKVGLIVSDIRKRKGLKETVPSYEEYYDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMT5</accession>
    <name>M7NMT5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_03023</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875074.1">
        <property type="nucleotide sequence ID" value="XM_007876883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMT5"/>
    <dbReference type="STRING" id="1069680.M7NMT5"/>
    <dbReference type="GeneID" id="19896710"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03023"/>
    <dbReference type="eggNOG" id="KOG0637">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018303_1_1_1"/>
    <dbReference type="OMA" id="SITQWAP"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005364">
        <property type="term" value="F:maltose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106081">
        <property type="term" value="P:maltose import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106082">
        <property type="term" value="P:sucrose import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004896">
        <property type="entry name" value="PucC-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF35">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 45 MEMBER 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03209">
        <property type="entry name" value="PUCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="548" mass="62555" checksum="73C3A582528048B2" modified="2013-05-29" version="1" fragment="single">MHQTYYHSTVTIVVISISMIGLYAHVNTSKDHFDETPQGLSSCEELREPPLRGTLYLLFLTLVLGGLQLTWSIELGYGTPYLLSLGLTKHYTSFVWIAAPLTGTIMQPLIGFFSDRSRSRFGRRRPFLVIGTLCVVISLIGLAYFKDVAFFFFSGHEKVARTVTIIISIAIVYLLDFSINIVQASSRALIIDMVPIIQQDLANAWASRMIGIFNVVGYLNGYLNLPKIAPVLGNTEFKALSLIGSIILVICTAVTFFTAKEKRYFIERGCDFEKIPWWMGLFNFLKMIFSTIISLPSEILWICIIQFFAWIGWFPILFYGTTYVAEIYAGKYCNKYSKYPDSLYSLEKEYLLIEEATRYGSFAFLLFSIISLFGTFFFPLFISEKKLFKYIFNAKCFSILEKINIHFLWTFGHFIFSLCMLSTILVRTTTQAVVIIALCGLSWAITLWAPFSLIAIELSSNNELHRSGTILGVHNIFITIPQVLSIIMVGIIFKLTGYKKFEDIIRCKDNMDYSFIWIFQISGISALIAMYLTFKLYTNDSSYERHGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMT9</accession>
    <name>M7NMT9_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873720.1">
        <property type="nucleotide sequence ID" value="XM_007875529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMT9"/>
    <dbReference type="STRING" id="1069680.M7NMT9"/>
    <dbReference type="GeneID" id="19895450"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01756"/>
    <dbReference type="eggNOG" id="ENOG502SGB5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_739921_0_0_1"/>
    <dbReference type="OMA" id="AWINECE"/>
    <dbReference type="OrthoDB" id="4160836at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027801">
        <property type="entry name" value="CENP-P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13096">
        <property type="entry name" value="CENP-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="67"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="374" mass="44294" checksum="45488D499C5B95AE" modified="2013-05-29" version="1">MYSNFQTKENPGYLSRFHEKSGQNHHFLRRSFSQISDKVEHEEQSRDTDSKILHLISSHKQIHMDEEDDIEKEKIFLMKQLQKTKDEIEKYRKEIYALERDKSEKKRRSHKNMNDLVESLLNSNNYFLENQPEPKIMANDTIISVLPISVENPIPQLRIFNQLNFHDTSNRIVSSEEHGHLIREHCLKGDCYNGHVFFDIKMLVDEGTLTVTFLDVKVSPWTYPELHDFLLLMMEEKNINNVFYGISSYSKLSTIRCDLFSRLSTKYPQLLSYDDYTFKMNKRLPEEFFGVQYLHFVHENGFELTLHWKIKMDNITADASSDISANPRYPETWELFDESKVLKKINDMFQKMIKYKGAYIASILLLSTLFQVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMW0</accession>
    <name>M7NMW0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear cap-binding protein subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_03294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875369.1">
        <property type="nucleotide sequence ID" value="XM_007877178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMW0"/>
    <dbReference type="STRING" id="1069680.M7NMW0"/>
    <dbReference type="GeneID" id="19896981"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03294"/>
    <dbReference type="eggNOG" id="ENOG502S34X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_819200_0_0_1"/>
    <dbReference type="OrthoDB" id="422106at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019416">
        <property type="entry name" value="NCBP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10309">
        <property type="entry name" value="NCBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="39191" checksum="FF7AC3DAF380B212" modified="2013-05-29" version="1">MILDENEEMELGIDDVEMDHEGENECKELDISLDEPRNVTKNKNGVAYNFKELGIQKNEFLNEVRPEALYLKGVDQMSTDDVKKYCITYYPTVSPSIEWIDDSSCNLVYSDASTALSVLSSISCFKVDTLYTSSLVPAKTCLKYNNAQLFIRHSSTSDKKTPGARERSRWYLFHPHPSEKRYISYRRKQNTSRRFSPYKYSRDQSNLEVNFLSKKDRPVLSSTLHDSSFLHSDCDRQTSENSLSLTSTSLKSNIELFPEKLANLTSNELFPKKLMKLNHRKISSEESNEVSHKELFPEKLNFQRHVSYFSSNNTTIEKTPFILNIKGSSKRRNKATDMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMW6</accession>
    <name>M7NMW6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane fusion protein PRM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_03049</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PRM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875104.1">
        <property type="nucleotide sequence ID" value="XM_007876913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMW6"/>
    <dbReference type="STRING" id="1069680.M7NMW6"/>
    <dbReference type="GeneID" id="19896736"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03049"/>
    <dbReference type="eggNOG" id="ENOG502QRP5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010191_1_0_1"/>
    <dbReference type="OMA" id="NVFGWVN"/>
    <dbReference type="OrthoDB" id="5356111at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032220">
        <property type="term" value="P:plasma membrane fusion involved in cytogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026777">
        <property type="entry name" value="PRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030:SF1">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0184">Conjugation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="639"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR08572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="756" mass="85538" checksum="1323301750AC7E17" modified="2013-05-29" version="1">MSQATHTFVHSLNCRDNNCKGSCRSPAQYSSQSFPKAPPLVYEKTGYESWEKNHNDNMNYHTYQMNYVPPDKNVPYLLLPARLSLIWVNKWTIALIILFVRLLFFLISFKKDMVNAEEKMHDAYTIIQYTANSLVLMPRSTAIGTNKVIALGIENSVRALNKTLILIILGVQHIILFFIEMIIHTWTCLLELSIQGGIKIIADVVEKISKFVNKVLKSIEKDILAGIQEINKGIASILNTIEKTAKILGKNIKVPTLSIPIEEKISNFSIPNNYDDELRKLGDRISLEPLKNTVKSSIAIPFYELRKLINNTLSNYSFDSSLLPVPSVDEFAIYSDNGDIDKVFKRLSNDIYTAVHSILLVLVILAILAIVPFAIKEWWNWKRLQSKAAMVWSIFSITKTFDPTEFILTVAYPWSTLLGLKFSSAFRNQHHKILIRWFISYIFHPSSLFVLFLGILGFISCGLQMILLSIMKKSLLSSPEENVPLNVSEKLQAASLKWSNDVNNVLNQTAVDLNSHIFGWVYASTQSINNTLNVFMETTTDSFKKIFGGTVLYQPILGVLDCMLFIKLRGIEKGLTWIHQNARISSPIIPNNILTSFVENSTSHTDFVSAAKSLNQKFYSILNTLIAGYEKSIIFEAKISFVLVSAWILIFVLGLLRIIFARKPVVRGLGGGPYSEFPSRAISNPIFKNKDEYDYIPSSAPRYTADPAKNAKIPPEFSKGPFIVDDNISDFAKYEPSGAVVEQYKSKNDKYRNRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMY2</accession>
    <name>M7NMY2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial phosphate carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_03312</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875388.1">
        <property type="nucleotide sequence ID" value="XM_007877197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMY2"/>
    <dbReference type="STRING" id="1069680.M7NMY2"/>
    <dbReference type="GeneID" id="19896999"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03312"/>
    <dbReference type="eggNOG" id="KOG0767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039456_1_0_1"/>
    <dbReference type="OMA" id="TCCAITH"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000024">
        <property type="entry name" value="MIR1p Mitochondrial phosphate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF12">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="18"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="115"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="215"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR08486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="33584" checksum="5302E23B5EB6209B" modified="2013-05-29" version="1">MGESQRRVSMLEKPQGVNLYARYAFSGAVCCAITHGALTPVDVVKTRIQLEPTVYKNMFDGFRQIVRNEGAGALLTGFGPTATGYFLQGGFKFGGYEFWKQYAINFFGIETATKNRTAIYLGSSAIAEFFADVALCPLEATRIRLVSQPKFATGLVSGFLKILKNEGVSAFYSGFGPILFKQIPYTMAKFVVYERAAEMIYSCIPTPKNLLSSGSNTSINLASGLAAGIAAAIISQPADTLLSKINKVQALPGETTVSRLFKYAKELGIRGSFTGLGARVVMVGILTSGQFAIYGDIKKAIGATGGVEIYPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN01</accession>
    <name>M7NN01_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA mismatch repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_03083</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875139.1">
        <property type="nucleotide sequence ID" value="XM_007876948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN01"/>
    <dbReference type="STRING" id="1069680.M7NN01"/>
    <dbReference type="GeneID" id="19896770"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03083"/>
    <dbReference type="eggNOG" id="KOG0217">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_1_0_1"/>
    <dbReference type="OMA" id="TPMMAQY"/>
    <dbReference type="OrthoDB" id="10252754at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032137">
        <property type="term" value="F:guanine/thymine mispair binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032138">
        <property type="term" value="F:single base insertion or deletion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043570">
        <property type="term" value="P:maintenance of DNA repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000710">
        <property type="term" value="P:meiotic mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000019">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="12">
        <location>
            <begin position="1000"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="139"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR08607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1166" mass="133752" checksum="5F4564638624BAA8" modified="2013-05-29" version="1">MEMKKKAEKMTQQTLLGFIKKSEKKKETNSLDFPYTPSKSSDLSSSTENCQDISFELETELLNLGETSFNGIFTPITLNIDKSKREESGEKENSSSFHVSPSFNRSRKKLNYKEDSEDEDDIGYISVKRKKSKVIHHSDDEFEMTVSENENGKNDESDSCSTVSSNQEENHLNTRKPRKLTNKDKKRNIEGKSIEMGKNMVVEDRYLSIDSPDKKLPFTSLFNTQKKSSEISNHDNEENYKFLLPEYRRDADGNSPSSPNYDERTLYIPPSTYKSFKPFEKQYWDIKSKFMDTLVFFQKGKFYELYQIDADIGHQLFNLKMTDRVGTMRMVGVPEANYEYWASKFIAKGFKIARVDQLESALGKEMRDKISKVKDEKVVRRELVHVLTSGTLVNEGIIASDMSTYCMAIKEEYEINSSVISYGICFVDAAAGNFKITYFKDDLSRTKLYTLITQIKPKELILEKANVTPKTIKLLKNSGINETIWNFIKPGIEFWDEHTTESQFLMNNYFKDNDFNNWPPALKKARNYPIAMSSVGGLVWYLKTLKMDKSLCSLGNFEWYDLIQKTSSLILDGQTLKNLEIFSNSHNGGLDGTLIKLLNRCTTPFGKRLFRLWLCHPLRSVNEINERLDVVELLSDLSIRKFIIDSFKTLPDLERMISRIHAKHCKSKDFIRVLEGFNTIYEILDYLSKNLKQDNGLLWKIINDIPNLVDVLNDWQKMFDWKKCKDEDILIPNPGTEKDFDNSQNKIKAIEDELYQMERDYRKQLKSPQITFRDIGKEIYQIEIPKSIEVPSSWVKLSSTKSVNRYWSPELKVKVRQLQEAREAHKTVIKNVQDSFFSKFDENYFQWLKVVKSIAYLDCLTSLSISSMEFAEPSCRPQIIDSEYSILEFDELRHPCIIPSVSSSFIPNNIKLGGSKDDPTIALLTGPNMAGKSTLLRQTCIAVILAQLGCWVPARRAVLTPMDSIRSRLGANDNIFGSQSTFMVELSETKRIIEESTSKSLVILDELGRGTSTYDGLAIAYSTLHKLSTYVGCLGFFSTHYHSLVKDFENHPKIAACYMAAHVDEDERKITFLYELRPGVSSKSYGMNVAAMAGIPEEIIKNAEIAAKKFEISSQSTQSNKTNYKSCISLASQSDFSWLMKLSISKDPIPSTPDLKRQLYVIANTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN20</accession>
    <name>M7NN20_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_03103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875159.1">
        <property type="nucleotide sequence ID" value="XM_007876968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN20"/>
    <dbReference type="STRING" id="1069680.M7NN20"/>
    <dbReference type="GeneID" id="19896790"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03103"/>
    <dbReference type="eggNOG" id="KOG1601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_541963_0_0_1"/>
    <dbReference type="OMA" id="ENIEGTR"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140849">
        <property type="term" value="F:ATP-dependent H2AZ histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037651">
        <property type="entry name" value="Swc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058986">
        <property type="entry name" value="Swc3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28108">
        <property type="entry name" value="SWR1-COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28108:SF1">
        <property type="entry name" value="SWR1-COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26242">
        <property type="entry name" value="Swc3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="2">
        <location>
            <begin position="468"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="503" mass="58271" checksum="B3CAED6DFFEEDCDB" modified="2013-05-29" version="1">MHENSSNTQDLTGCDFLSKKNNSLRQKILNGFGLPIFNKPQVISEENNDKYKTIEESGVLASCISQSRQALLQGLIFEKFSKNYCSKKQDDEIEKTNIKQKISKIGNFTLHIELFSFPETVFYLVKYVTKTDNNLSCENIEGTRQLENTDTLFSCKNKDTFNSANNDINVIKSENIANYSTFTPEIKYLDFFEKYFLEIFKNDPLKLEKTDKAIERLKIVPLNPDFKEILHLIMTGKATIEQKKIFNLYMTSPQSSQIPSNYNEKITISSVFQNKCLENKNNNKKVTKTKQKKNNNYKDAEIIFEFKENPGEKWILPKDIIIEKLDTKEPFEVLISFIYIEDSLSQFQPITLKISSCSQKLWDFISKYSNDKEKVCEAMSKILIGKRSEKLYFQYRITITDTKTFKNESEEKINIISRNKKSVLPQKRKTIDENDITTLSSTNNKSTSPIISKKIEKKHIVFPKDWNCNICNTTETPLRRRGPDGPGTLCNACGMRWKGGKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN64</accession>
    <name>M7NN64_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_01406</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Dephosphorylating regulator for many key proteins. Has an important role in osmotic stability and cell shape control. It may negatively regulate the osmosensing signal transmitted through wis1 map kinase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:20630"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873342.1">
        <property type="nucleotide sequence ID" value="XM_007875151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN64"/>
    <dbReference type="STRING" id="1069680.M7NN64"/>
    <dbReference type="GeneID" id="19895103"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01406"/>
    <dbReference type="eggNOG" id="KOG0698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013173_4_3_1"/>
    <dbReference type="OMA" id="GPGIRNQ"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990439">
        <property type="term" value="F:MAP kinase serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071470">
        <property type="term" value="P:cellular response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903753">
        <property type="term" value="P:negative regulation of p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000016">
        <property type="entry name" value="Protein phosphatase 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF565">
        <property type="entry name" value="AT28366P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR10128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="372" mass="41076" checksum="C05EF08E4819B6DA" modified="2013-05-29" version="1">MGQTLSEPIVEKRSQKGGDDTLLFGVSDMQGWRISMEDSHAAVLQLNSGSGKDKVSFFGVYDGHGGDAVAQFSGEHVHRIISQDTSFIAGDYEKALKNGFLNTDKAIREEPRFKEDPSGCTASVVLITGDGRVFCANAGDSRSVLCVRGEAKPLSFDHKPQNEVEKARICAAGGFVDFGRVNGNLALSRAIGDFEFKKNADLPPEQQIVTAYPDVTEHQLDEDDEFLVLACDGIWDCQTSQAVVEFVRRGISAKQELHKICENLMDNCLASSSETGGLGCDNMTVIIVGFLQGKTKEEWYDMIAKRVENQDGPCAPPEYAEFRGSGYEYGHWNHNQVENSYEENEEDETNNETSVPFEKSWIWSSQSDFSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNB6</accession>
    <name>M7NNB6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="9">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_03087</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 16">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="9"/>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875143.1">
        <property type="nucleotide sequence ID" value="XM_007876952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNB6"/>
    <dbReference type="STRING" id="1069680.M7NNB6"/>
    <dbReference type="GeneID" id="19896774"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03087"/>
    <dbReference type="eggNOG" id="KOG2108">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004585_4_2_1"/>
    <dbReference type="OMA" id="DYPDATT"/>
    <dbReference type="OrthoDB" id="1470711at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990426">
        <property type="term" value="P:mitotic recombination-dependent replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17932">
        <property type="entry name" value="DEXQc_UvrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18807">
        <property type="entry name" value="SF1_C_UvrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.486.10">
        <property type="entry name" value="PCRA, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF2">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE SRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="12">
        <location>
            <begin position="9"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="13">
        <location>
            <begin position="300"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR08611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="872" mass="100882" checksum="A020D265CA6C29AE" modified="2013-05-29" version="1">MATFMSLMDSLTTQQRLAVTSSQRFLQILAGPGSGKTLVLISRIIHILLEQNVFPQEIVVVTFTNKAAKEIKNRIGTIIGEDIGNRIVSGTFHSFARQYLVKYGYLIGLGIFGIADRSDSIFLIKKYLKEKNIIELEISINNTTIKLSANSITNLISSLKSKGITVFAYSDLGRFTNSSKFLYHQEILNIYSYYQQSLLENNLLDFDDLLLHCLQLFKEYPFCVKDIKYVFVDEYQDTNLIQYDIIKSLIHEKSSLTIVGDPDQSIYGFRFADITNFERMKQDFPDSGTLFLEHNFRSSGAILQTALALIEQGKYITIYSLKDGFTPVLKVLEDNVKEAQWIAKEIKKYVENTSGFLTYKDFSILVRSSVLTQPIENAFQKFGINYKMVGAYKFYDRQEIRDIIAYLRLICFNDELALSRIINIPNRGIGKNRWDFIVNKSKMDKKSILVILEEITKGKHNTGKIIDKNVENSIISFINTINKIKNYMNTQINSPISNVLLYVCELLDYEKYLLKKYPDNFHERWNNVLQFINNFNNINSEDDDMYSHMSETNNIYQKLLIKFLDNISLFSDTIENEDNSCLKVTISTIHAAKGLEWPIVFLPGLYNGSVPHSRAEDISEERRLLYVAVTRAQAMLYLSYPTKNSFQDKLELSSFLKKISFVSSFEKQNPKLDIPFIKTLSELLKRSTPILNFSTINIYNNNIFIDSRFCNFYKEKNKNTAEIKHFEYSSNDMDMSEGQLDPKYTGFINLKTILHNQLNDYNQTQLSEQKAYNFKKNKTHQSVESTLNNETKHLNISLKSRPKCLNKYINIQKLDIQENTSDNNDISLESQTILSKIQPIQPLRTNKIIEKPIVKRLGIRRSMPKRTLFYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNQ4</accession>
    <name>M7NNQ4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vacuolar import and degradation protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_02667</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874688.1">
        <property type="nucleotide sequence ID" value="XM_007876497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNQ4"/>
    <dbReference type="STRING" id="1069680.M7NNQ4"/>
    <dbReference type="GeneID" id="19896358"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02667"/>
    <dbReference type="eggNOG" id="ENOG502QSEY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018197_0_0_1"/>
    <dbReference type="OMA" id="HENHINQ"/>
    <dbReference type="OrthoDB" id="5364245at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459:SF1">
        <property type="entry name" value="E1A-BINDING PROTEIN P400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459">
        <property type="entry name" value="E1A-BINDING PROTEIN P400-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00573">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSA" evidence="11">
        <location>
            <begin position="242"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="487"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="618"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="794"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR08882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="820" mass="94430" checksum="38124C9C08A9C3F6" modified="2013-05-29" version="1">MSIDSSKNEKKVELDTSKEILEKKIKLKNEIELRQKELLIELFILSSLEKYFPDIDVGICEKISSSDELKTFLLKNSLQNGLKFDESILQSYISSQENLTSLKENETSEVTETLFVDSLSENPEKVEICDSSSVFKDKAIEEQLKPTTPHTYIEPSVQNSDCFSLHVSRHSPSCKQNKTSHTDLLSWLIQTSSMPIYKLMQSSNKIIATKDWNTAIIETKFIKVLERINKLKENNLWSFRQMIKQKTPSRLKAHWDFMLDEMRWLQADFKEERKWKIVLAKQIANWIMDWHRLKTRSDVCFQPNSNKSYISFSKNEKYNIIDFNQDKKNNKNKSFSDTESEMKNDSSENIFTLHSSPLFIIENAVQLLEIPPDKIIATFSNILLASNTVLPDLPVYRPPVPEDTLYYDPLDEMKIIPLSKYTQSHIKISHSDKFFKKRKREASIDTDDIADKQRIVINEFPLSNSISTTRKKSTYPSQLRPPNIPLNLENHKPIWSPDEDNLLMTYLPKYQFNWEFVAQTLTPSIKWISSAEKKTAWDCFERWVQLDPHASNVIFVGPYAKTAYAKLEPLLKNSRSNSYGGIFHSKKDIGKNSLSSRFKRQRQFNMFDAIRKTMKKREVSQKLNVAPSKKVNTSAHDTHGLSHKPSIAAPTPLDLSRLKHERDQVITQAYIRQRNAVVALALQNQARSSGRSNFPEINSTSQQMAQVQSVNSQINIQNRVQSASRTIPGMVNGLRFNRSVHPSTPSQTLVNPTGVAPILRLPPGVHLSQEQMQQLVIQRQQLLQAQRTQVQNVQQTAHCSDSEQNENPVESRHLASLNQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNT3</accession>
    <name>M7NNT3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NAD+ kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01606</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873563.1">
        <property type="nucleotide sequence ID" value="XM_007875372.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNT3"/>
    <dbReference type="STRING" id="1069680.M7NNT3"/>
    <dbReference type="GeneID" id="19895301"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01606"/>
    <dbReference type="eggNOG" id="KOG2178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008831_1_1_1"/>
    <dbReference type="OMA" id="LFQKHVP"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000009">
        <property type="entry name" value="Poly(P)/ATP NAD kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="50964" checksum="201DEB17C3454953" modified="2013-05-29" version="1">MPEKKVLRQRSRSFNTNSLETREFRKKHISSDNFFDCYLEKQENKNQDKEISLNYQIKDLKTRFIESHSKKKLSDMVFNIGELYKSLDEVRIILEIKNILIITKAHDKSLVLLTRKLVIWLLSYESNPEKKYNVYVESTFKNSCDFDSKNIIKSNPSFGNYLKYWTFELCTEYSSLFDFVITLGGDGTVLYSSWLFQKTVPPVLSFSLGSLGFLAMFDFSTFDTTLGNLFSNGVIISLRMRFQCTIMRVKVDDNGEPIDKTRNLDRSILNDKKSEISLTHEPKESFSILNDLVVDRGPNPFLSSIQLYGDYEYFTSVQADGICISTPTGSTAYSLSAGGSLCHPDIPAILISPICPHTLSFRPLLVHDSMILHVAIPYNSRSTSWVSFDGRNRVEIKQGDYVTISASKFPFPIVLRSKQNSEWFTGLATRLGWNERTIKLKPLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPI1</accession>
    <name>M7NPI1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hsp90 chaperone protein kinase-targeting subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02781</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874812.1">
        <property type="nucleotide sequence ID" value="XM_007876621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPI1"/>
    <dbReference type="STRING" id="1069680.M7NPI1"/>
    <dbReference type="GeneID" id="19896470"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02781"/>
    <dbReference type="eggNOG" id="KOG2260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033261_0_0_1"/>
    <dbReference type="OMA" id="NYSKWDQ"/>
    <dbReference type="OrthoDB" id="440202at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.610:FF:000002">
        <property type="entry name" value="Hsp90 co-chaperone Cdc37, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.610">
        <property type="entry name" value="Cdc37, Hsp90 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004918">
        <property type="entry name" value="Cdc37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013873">
        <property type="entry name" value="Cdc37_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013874">
        <property type="entry name" value="Cdc37_Hsp90-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038189">
        <property type="entry name" value="Cdc37_Hsp90-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800">
        <property type="entry name" value="CDC37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800:SF4">
        <property type="entry name" value="HSP90 CO-CHAPERONE CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08564">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08565">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03234">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01069">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01070">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01071">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101391">
        <property type="entry name" value="Hsp90 co-chaperone CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc37 N-terminal" evidence="10">
        <location>
            <begin position="2"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 Hsp90 binding" evidence="9">
        <location>
            <begin position="176"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 C-terminal" evidence="8">
        <location>
            <begin position="365"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="451" mass="51769" checksum="ECE151E871B0974C" modified="2013-05-29" version="1">MVLDYSKWDKLELSDDSDIEVHPNVDKRSFIRWKQRDIHEKRQARKQAIYDISSNLQMNKDLKEQVLRLIYALKTSNQEPDKVVMNILQEISLENIPHIEGAVKYNVSIGRLIEKVKEKLGETEGEKRRQGFIKNFEENIEKLEELINKANQDLEKLEEEGRGKITSEDIRVGFESSSITKLPTTKKKEKVQTIEILNKKTLEDKTTEDVCLTENDSNMDDNTEHIEPSETGREFSKVNSQDYHALLNFISLHPDIVLDERETDGLLIDAFNYQMQGNEKLAKQCVHQGLLLQYCRQLGKDGVSLFFQRVTSANHAAYKLFNDDVEQTYSRIKVRAAEIMEERETSSGVEQIQLHAVDPNAKISINIPPKDSEDPNVQEARKIFESFSLDLQDALESGQLENINKVLANIPLQEAEKIVGDLNRGGMLSIENEMIDATKGDFCINKDKENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPK8</accession>
    <name>M7NPK8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin-like protein ARP9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873272.1">
        <property type="nucleotide sequence ID" value="XM_007875081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPK8"/>
    <dbReference type="STRING" id="1069680.M7NPK8"/>
    <dbReference type="GeneID" id="19895040"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01343"/>
    <dbReference type="eggNOG" id="KOG0676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_531127_0_0_1"/>
    <dbReference type="OMA" id="RYIFEKT"/>
    <dbReference type="OrthoDB" id="74201at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10208">
        <property type="entry name" value="ASKHA_NBD_ScArp9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="57994" checksum="7EDD78EE54317C87" modified="2013-05-29" version="1">MPLTTFRDENIIVIHVGSYKTRAILGLSESLTPPTVKILTRVGIRKGLNNEIREKNCQENYLVGADLDEALISDKDIEIIWPIKQGVVKNWKALEAIWNYILYKIMNRPYPPQPRTFVNPVYLIVPPQWNFRDKELATRIFFEEHLVAGFAIGNSSVLPLYAMGHLSGLVIHIGHEKTDITPVLDAQAVVPARVTIPIGGKSITEYLHSLLLSSPPILKETNTPLLPEEITFELSEKIKCSNIVEVIVENAQESFQKLLNRENDNLPFPDSSMDGVEDVASIVASGKTREYLAQKEAEKNQSKKGQKAENVILDNKQMIYNQFTMDNNQIILVGKERFRMCDFFFNDVKDGRLDILNAVYIATNNPSIESNRRAELWENIAIVGEGSRIAGFKERIFSDLTQKYVSVIENSSQKHHNLPISTYTTSNTSSNLNSSYLVYHNPPIIFPSTIRLAKIPDFFPEWKSDRNSNAVLEEACFLGGEIVAKLSFNDPSSKNYMGRGEYNENGPPYINEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ01</accession>
    <name>M7NQ01_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874286.1">
        <property type="nucleotide sequence ID" value="XM_007876095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ01"/>
    <dbReference type="STRING" id="1069680.M7NQ01"/>
    <dbReference type="GeneID" id="19895985"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02292"/>
    <dbReference type="eggNOG" id="KOG2689">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034966_0_0_1"/>
    <dbReference type="OMA" id="MCILARI"/>
    <dbReference type="OrthoDB" id="2445133at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23187">
        <property type="entry name" value="UBX7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="211"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="385" mass="44419" checksum="CCDB2887B927345E" modified="2013-05-29" version="1">MKNDIWSQKSIEESIRLCLDKRLIFLVYIQGDDEKWIDNLLTPQVCKEIKEKTVSLRLFNGTIEAMSFKQMVVVNSVPSIFLIKDGLVKKSFYGNATAENLIEGIQSLSREKSMSNISEYEGACRNLLNIQEKDGISSIKSAKMNSKDGGKRKKYVEELKKMKKKDLEERMCILARINADKEERKVKEQYRISARSNEVSIFTEDTSFQQSAKNICLLNIRLLNGSSIQAKHFTINNTLQDVRQWIDENRTDNKIPYDLIQVYPKRLFSISEEVKTLEVLNLYPSATLVLKPIKNAISAYVNLDKGYFSKLFGAFGYFKSNIYSIFGWISAVINKNKTIKKMEQNKKVHSLNDQQISTSDNRNRDKNVWYNGNTLNQEPPVEKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQD5</accession>
    <name>M7NQD5_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat NOL10/ENP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874050.1">
        <property type="nucleotide sequence ID" value="XM_007875859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQD5"/>
    <dbReference type="STRING" id="1069680.M7NQD5"/>
    <dbReference type="GeneID" id="19895764"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02070"/>
    <dbReference type="eggNOG" id="KOG2321">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009923_0_0_1"/>
    <dbReference type="OMA" id="GYFMDVR"/>
    <dbReference type="OrthoDB" id="273340at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056551">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040382">
        <property type="entry name" value="NOL10/Enp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056550">
        <property type="entry name" value="NOL10_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23098">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23097">
        <property type="entry name" value="NOL10_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nucleolar protein 10-like N-terminal" evidence="8">
        <location>
            <begin position="5"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar protein 10-like second" evidence="7">
        <location>
            <begin position="386"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="6">
        <location>
            <begin position="497"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="682" mass="79434" checksum="E5322CCA4AA306B6" modified="2013-05-29" version="1">MVLKVQNPNNIKVYTVCGEGTSRSLPEWFIRKKKKALKKDPEWSSRIELLQDFEFPEASNKIKVTPDKKYAIATGTYKPHMKIYEFSEMSMKFSRYTNAENVNFEILSNDWTKTVHLQQDRSIEFHTQGGMHYRLRIPKFGRDMGYHFPTCDLLIAATGDEVYRLNLYQGRFLRPFKIDSLADNEEGTNKMGVNTVNINPVHQLFAFGTDNGTVEFWDPRYRSRITILDISRSLNPMFHKKTAEISATSFRHDGLNFSAGTSTGIVLLYDLRSPQVLLQKDQGYDSPIKSIKWLKSNDSVSQLILTSDKKIIKIWDKNSGNPFTSIEPSVDINDVCPLDFTGMIFVANEGVPMHIYYIPALGPAPAWCSFLDNLTEEMEENPIENIYENYKFLTKNELKSLGLDHLIGSNVIRSYMHGFFIDFRLYETAKSIMNPFAYVEYREKAIKDKIEKERQSRIRSSTKITKINHNLAQHLLHKEEKDRMKKKGNRGPSVLEDERFKDVFNDPDYEIDENTVEFMQLNPIRSKKNYENSKTISSSESEKKSIAYSFSGTDDDNDESEEADFYQKPKNMELKAEDKEIRMKVIEYYQPSLNTMQNESFETLIKMQEQNKETEKKQDLMINDIKRNINGKGNMEMTFLMPKKKNNINNNMKNTHCTLETEKNDLKQVSRRRASKNTFRKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQV3</accession>
    <name>M7NQV3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874059.1">
        <property type="nucleotide sequence ID" value="XM_007875868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQV3"/>
    <dbReference type="STRING" id="1069680.M7NQV3"/>
    <dbReference type="GeneID" id="19895774"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02080"/>
    <dbReference type="eggNOG" id="KOG2684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021544_1_2_1"/>
    <dbReference type="OMA" id="QLHGSIN"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099115">
        <property type="term" value="C:chromosome, subtelomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140765">
        <property type="term" value="F:histone H3K56 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140861">
        <property type="term" value="P:DNA repair-dependent chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009299">
        <property type="term" value="P:mRNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046459">
        <property type="term" value="P:short-chain fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF15">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="5">
        <location>
            <begin position="29"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="394" mass="44984" checksum="D58CF33F5F4A1079" modified="2013-05-29" version="1">MNHVFKYKEDGKKTVKISFEEPLMIDLFENKNNDLYIELVKHVMTKSKKVVVFVGAGISTGAGIPDFRSENGLFATLRSNFKLKTSGQDLFDISVYKNENDMKRFHKMISDLYRISASAKPTLFHEYLAALARSSQLIRLYTQNIDFLETRMPYLESQAPLPMLPPWPKTIQLHGGLQNMICSKCYWTGPYDPDIFKDDSLSVCHQCIEMENIRTIAGKRNIGVGKLRPRIVLYNEYNLDSEAIGKVTEYDLKEKPDALIVAGTSLKIAGARKIVREMIEAVKASHGVTIWINTSDFPKPKEFEKKFDIVIKGDCQKVADLVLLKNDIANIHSKEPSYVLDPSSIKQTFTDDLFIDQHTNTIYFSKRKRILKEQPEISKIFKSVKLTKGIKVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRA0</accession>
    <name>M7NRA0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Histone deacetylase</fullName>
            <ecNumber evidence="3 11">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_01946</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3 11"/>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873923.1">
        <property type="nucleotide sequence ID" value="XM_007875732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRA0"/>
    <dbReference type="STRING" id="1069680.M7NRA0"/>
    <dbReference type="ESTHER" id="pnemu-m7nra0">
        <property type="family name" value="Arb2_domain"/>
    </dbReference>
    <dbReference type="GeneID" id="19895640"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01946"/>
    <dbReference type="eggNOG" id="KOG1343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007727_4_0_1"/>
    <dbReference type="OMA" id="CFVSPAC"/>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070823">
        <property type="term" value="C:HDA1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990342">
        <property type="term" value="C:heterochromatin island"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070824">
        <property type="term" value="C:SHREC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140720">
        <property type="term" value="C:subtelomeric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031078">
        <property type="term" value="F:histone H3K14 deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902794">
        <property type="term" value="P:siRNA-independent facultative heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000005">
        <property type="entry name" value="histone deacetylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019154">
        <property type="entry name" value="Arb2-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017321">
        <property type="entry name" value="Hist_deAcase_II_yeast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF5">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09757">
        <property type="entry name" value="Arb2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037919">
        <property type="entry name" value="HDAC_II_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="12">
        <location>
            <begin position="122"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Arb2-like" evidence="13">
        <location>
            <begin position="484"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR09762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="735" mass="84033" checksum="3B909BB373F607D4" modified="2013-05-29" version="1">MRTLHRSRKEDVIVDEKISIIGISNLNGVSMVKTDNSLKDKNETQNMDNNSTLNDEKEVKMKEFEVFKESFGKKEGFVVSNDTRSVNESTLSKKKYKFKLKTGICYDVRMRFHATINPVDFHPEDPRRIYRIYKEIADAGLINYDGWSWSNMNEQEIMERISARELTREEALLVHTENHWDRLLQTADMSVNELLYFESIYNSVYFNNESAFCARLSAGGTIETCIAVAEERVRNAIALVRPPGHHAESDCPMGFCLFSNVAIAAKCILQKFSNIQRILILDWDVHHGNGTQRIFYDDSSVLYISLHRYEDGRFYPGSKYGNYDKVGVGKGRGKTVNIPWPCKGMGDDDYIYAFQKVVLPIAYEYNPNMVIISSGFDAAMGDEIGECFVTPVGYAHMTHMLMGLAQGKLVTVLEGGYNLDSISSSALAVTKTLIGEPPPELKITKVSDACIEIIQKVMLEHSKYWNCMRPKSLELNMGSHCIERLDNIIRSYQTKKLFEKWKMIVLPIIKESISFFENQIICTRDFYKAETLVVIVHDAPDVVGYSYASINKINICNSFLIDSLNLYIEWAIKNQYGLMDVNIVSCLDTLNNESYNVASASQELCIYIWDNHLEMADAKNIIFIGVGQGCQGFIHLMEYRDIYDRVDAIVQFYGDNSLKAISSNDEIADWYFKHSLVLTSNRHPIWNLPKRIKRKFGRVIRSDSNEINEILENSFNKVSAFFQDILESNTAIVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRB8</accession>
    <name>M7NRB8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873948.1">
        <property type="nucleotide sequence ID" value="XM_007875757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRB8"/>
    <dbReference type="STRING" id="1069680.M7NRB8"/>
    <dbReference type="GeneID" id="19895664"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01970"/>
    <dbReference type="eggNOG" id="KOG1180">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_45_2_1"/>
    <dbReference type="OMA" id="RWEPVFH"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="94"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="676" mass="76251" checksum="3723327177CDDBAB" modified="2013-05-29" version="1">MKALFSKEYSTEDIKGESRIRRSVLSMNELVVRPSPDINTIYDILIRSYKLYGSRNAFGFRKILQVHTKNKELTKIIGGKEIKVQKDWMYYELSDFEYITYKEFYEKVHNIGSGLRSLGFLKNDRISIYAATSVEWLTMAFSCISQALTIVAAYDTLKDGLLSCFLETEIKGIFCDATLLSNIVIFLKSITTLKLIIYHGKPQEDVLECFKEYKDLKVLSIEEVESFGKNNPADPDPPLPDDLICIMYTSGSTNVPKGVLMTHKNVVAAVSGITFVFESYIDSNDSVLSYLPLAHIYEFVFEIFAFYSGLLIGYGTVKTLSDANCLNCKGDIQAFRPTIITGVPAVWESVRKGIIEKLNSSSKIKQKLFWAAYNIKSRLLLRSVPGIGILNALVFKHIRVAMGGRLRVIFNGGSSISIETQKFLSTVLCPMLIGYGLTETCATCTIMAPNEFSLGTVGSISTTLEAKLVDVPDAGYFTDSTPQQGEIWFRGAPISKGYFNRDEEDKEVYTDDFWFKTGDIGEWTENGQLRIIDRKKNLVKTLNGEYIALEKLESVYRSCNIISNICIYADPYHLKPIAIATPSEALKKNLLDNGVSFEDDISLICKNKEVRYFVLNELLKIAKKNNFATIEYLENIILIDEEFSSQNGLLTAAQKFQRKKIYAKYKEEIDAAFQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRI3</accession>
    <name>M7NRI3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872245.1">
        <property type="nucleotide sequence ID" value="XM_007874054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRI3"/>
    <dbReference type="STRING" id="1069680.M7NRI3"/>
    <dbReference type="GeneID" id="19894070"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00372"/>
    <dbReference type="eggNOG" id="KOG4107">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141118_0_0_1"/>
    <dbReference type="OMA" id="ASSIWND"/>
    <dbReference type="OrthoDB" id="271745at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037587">
        <property type="entry name" value="LAMTOR2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13323">
        <property type="entry name" value="LATE ENDOSOMAL/LYSOSOMAL MP1 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="16407" checksum="12C451D2A93699AF" modified="2013-05-29" version="1">MIKTKALMSLLSQSLDSSITSSILLTSSGQLLSQASESQKKARIYAAFAAHIWSCYEKIGLDGKIGSLTGENRKIFGCNWLGIECLTGNLLILCIRFPQLEKSLHVSVLSEPILLCLVGNESSKLGFMHMKAESIEKYLLKELEGIRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRS2</accession>
    <name>M7NRS2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00467</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872349.1">
        <property type="nucleotide sequence ID" value="XM_007874158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRS2"/>
    <dbReference type="STRING" id="1069680.M7NRS2"/>
    <dbReference type="GeneID" id="19894165"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00467"/>
    <dbReference type="eggNOG" id="ENOG502RY8V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026932_0_0_1"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="209"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="339"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR11448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="665" mass="75376" checksum="A6C398F39E3EC79F" modified="2013-05-29" version="1">MGPSGYSHDSSLCPDAKKEISGDFLRAYKVLESSNEIDKENFVFTELYKHDALSSRFSGFDNVGISRSVLQPKSNYVVQSANIPKSMNILVKPVPETDDCKLMDGCDEVLSPDSCFYSQPIIKPPKTANTKQFKSSTSVKPACWILEECSPKDLSEHLDALNIKNEATIKSFETFPYTQESSSSLKAEKSIFGNSSYMSNMTIPYKKSCNECNTDNAEFVLTPCGHKICQRCLSSLISNVPINLYICFICHKEITNFTRKSSLESTLLSSKLQSVSEFGFPKASSLLNSFEVKQSRHTVFSDKSSESLNSTVDCLLKDSLVLENPFSDISTLVTPQDWTCLKISNIPWDLSIESIHEFLGKNARIAPYNVHSQSIHFIMDRMSAKTQSECYVELSSRNDAQRLAERRSGKLLGSRNVILEIATQEELMNRIFPKWKGEWKGVNPYVDENLKSIRQFSVPKAEIVTREELNSLINHVKTYRSPYSRKCPQRPFEDFISILAKFPWHKGDFYTVSQRDLLHSSLITLIEILKGHFKKGRLIELNFRLLERLVHAGTTNTCFTEKQKFEIFKMAGLSCNFETNRISLMNLDLKAVSCFKVDHLHTTEILSFLMYNGFKIDDLQLSGKDTCSLSDIAKIEMSYINSKLLEYQSSVLSTTLHSAFVSSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRX6</accession>
    <name>M7NRX6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02032</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="5">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GcvH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874012.1">
        <property type="nucleotide sequence ID" value="XM_007875821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRX6"/>
    <dbReference type="STRING" id="1069680.M7NRX6"/>
    <dbReference type="GeneID" id="19895726"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02032"/>
    <dbReference type="eggNOG" id="KOG3373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097408_1_2_1"/>
    <dbReference type="OMA" id="EHEWLSG"/>
    <dbReference type="OrthoDB" id="10264154at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="55"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="4">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="159" mass="17973" checksum="949D936D7ED3AEA5" modified="2013-05-29" version="1">MFFFSKILPYTVASKVFIHPVSFRQFRNFHFSKVYYAIKKYTKEHEWISLDDNGIGVVGITDYAQKALGDVVFLELPEPGLIFSKGDSIGVVESVKSASDIYAPLSGKIIESNNSLLGNPGLINKDAESDGWICKIKIDDIHEFNVLMDVDDYKMYCDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSB4</accession>
    <name>M7NSB4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Checkpoint protein RAD24-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00082</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad17/RAD24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871938.1">
        <property type="nucleotide sequence ID" value="XM_007873747.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSB4"/>
    <dbReference type="STRING" id="1069680.M7NSB4"/>
    <dbReference type="GeneID" id="19893780"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00082"/>
    <dbReference type="eggNOG" id="KOG1970">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_445579_0_0_1"/>
    <dbReference type="OMA" id="ECDALMD"/>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004582">
        <property type="entry name" value="Checkpoint_prot_Rad17_Rad24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057927">
        <property type="entry name" value="RAD24-like_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03215">
        <property type="entry name" value="Rad17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25812">
        <property type="entry name" value="RAD24_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Checkpoint protein RAD24-like helical bundle" evidence="8">
        <location>
            <begin position="390"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="613" mass="71137" checksum="03BC6295AC12D408" modified="2013-05-29" version="1">MRKKMPLKKLKIEETDERLSKHFLRSSKERVSCKKEKKCFGLKDSLFESENKYLECDSICIESDSEEENYCSRFVRSVGKRSRNIMAIFDRIEKNKIEKKSKYDDILMWNEKYKPLTVNDLAVNKKKVAEIRNWLSIALKQDLEKKLIILTGPPGSGKTATINVLSQEMGFEILEWQNPMTILSEDMELDHLSLFSKFENFLLISKQYSSLDFDGTSNVFSDSKIILIEDLPNIYTSSPGTPDKEHDFQLAILRYISSSRNKYPLVLIITEMDFKEFDETDNKRVKGLSLYSLLGRTIIESEKTVQISFNPITKISLQKTINKIIDIECRYSQKPSLELIESIIESSCGDIRSALNSLQFIVGIILENSSKGFSKEKGLLINSIINRDITLGFFHAVGKVIYNKRIGDSPEDKFEHFFPKNSLPFHLKVYERRISKVNPDNILDTIPVSYDIYILALHHNYLESCNDIKHVDFILSFLSYSDTMLSAKVWHYSLQQRMSSLVAIMGLLIGLPSPVKRSFTSKIVYPVYQKILQEMKLKNDYFIDSIYKSYCNCYNLYYNTMKSSISMITEIFPYQSLILKKKTSFFDIPALIDKDESHKFLLYDINDDIESFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSD2</accession>
    <name>M7NSD2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01451</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873391.1">
        <property type="nucleotide sequence ID" value="XM_007875200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSD2"/>
    <dbReference type="STRING" id="1069680.M7NSD2"/>
    <dbReference type="GeneID" id="19895148"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01451"/>
    <dbReference type="eggNOG" id="KOG0108">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028601_0_1_1"/>
    <dbReference type="OMA" id="NEYEIMG"/>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12398">
        <property type="entry name" value="RRM_CSTF2_RNA15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.70">
        <property type="entry name" value="Transcription termination and cleavage factor, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025742">
        <property type="entry name" value="CSTF2_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026896">
        <property type="entry name" value="CSTF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038192">
        <property type="entry name" value="CSTF_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14327">
        <property type="entry name" value="CSTF2_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14304">
        <property type="entry name" value="CSTF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="8"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="263" mass="29167" checksum="96E6032BC439081E" modified="2013-05-29" version="1">MSTKAPSKVVFVGNIPYDVSEEQLKDIFRQIGPIHRFRLVFDKETNKPKGYGFCEYPDIATASAAVRNLNNHDINGRQLRVDFAESDPAQDNNRRQQQVTQHEEISSQTKSDILPMLPQGTAPPPGVSAVDAISRTLSTLPPLQLLDIISQLKALVHINPEQAHALLLQSPQLSYAVFQAMLMMNLVEANVLHKVIASTGHPQVSPPVNTVSYTQPQQNTQDLQRAAIYAQVMSLTDAQINTLPYDTRNQILLLKQQIAMGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSS7</accession>
    <name>M7NSS7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Neurochondrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872093.1">
        <property type="nucleotide sequence ID" value="XM_007873902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSS7"/>
    <dbReference type="GeneID" id="19893922"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00224"/>
    <dbReference type="eggNOG" id="ENOG502S540">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_608476_0_0_1"/>
    <dbReference type="OrthoDB" id="8962942at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008709">
        <property type="entry name" value="Neurochondrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13109">
        <property type="entry name" value="NEUROCHONDRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13109:SF7">
        <property type="entry name" value="NEUROCHONDRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05536">
        <property type="entry name" value="Neurochondrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="53016" checksum="58D6D7F59E2A1639" modified="2013-05-29" version="1">MNSFIETLDEVLFEKMINLMKHACIKSVSDMEEINFKLSLKKCINDLINILENSKGKKRLIMFSFFNDVFSNINTGICNSLIKNMEIKKALYNILHTLIKEDQSDSTRKMTSNLLCLMLRLQNLEFILSCASNEEEARTFCVLFTNLASVDIRSILPTVMKKLISEEINEESHRLSTDYEILESMIIYLSNSETVVFQFSELLLLQRSFKEAFEESIDFLKDRWDNFNKNKNSLKNDPEIFNDLIVISSIRSLCLWLKEDDSLRKYAISIMDMFMYLWNKKNAFDIDYRIWICDGLQGIITTEEGWNSFHSLGFWDAISTNLIKNELEEPDHSCIYTKLSECDLLLQAIERYQNPQKNWINIIKYPKKINKNDPLKAEFFIKIIILSLIIFQKLGKDFSKQNEQLFSEHLEISLTWIHFLDSKRLNCSWTIPIELKDKMLIHLQNLHPFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTC6</accession>
    <name>M7NTC6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial distribution and morphology protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mitochondrial inheritance component MDM10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MDM10</name>
        <name evidence="7" type="ORF">PNEG_01587</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins. Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. Associates with the mitochondrial outer membrane sorting assembly machinery SAM(core) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion outer membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="6">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MDM10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873541.1">
        <property type="nucleotide sequence ID" value="XM_007875350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTC6"/>
    <dbReference type="STRING" id="1069680.M7NTC6"/>
    <dbReference type="GeneID" id="19895282"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01587"/>
    <dbReference type="eggNOG" id="ENOG502QUN5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026505_0_0_1"/>
    <dbReference type="OMA" id="VPGYRQI"/>
    <dbReference type="OrthoDB" id="2103793at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051654">
        <property type="term" value="P:establishment of mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03102">
        <property type="entry name" value="Mdm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027539">
        <property type="entry name" value="Mdm10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12519">
        <property type="entry name" value="MDM10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1 6" id="KW-1134">Transmembrane beta strand</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="385" mass="44057" checksum="B205CEAEE85392C5" modified="2013-05-29" version="1">MIEYKEYIIRLFFENTCWNSDNLYSFLCESSKNILDFHVSKGLSFNISSSPSENFASSYCLSLSPDLNGSIGYIVSSFPLYGSKNSHTIPINKISEVYHQVQEFKDLKKCWNQTFNSRRKDYLFYGRMYFPELLLEGLYARKISPTKQFILSYFNNPEKSDGISLTAQFQHNTSKWSTEYTYSTDDAMFGFRGLWNFGEVPKRVSINEKQNDDSASLSNNGQLSIGTEVYYGIFHKIGGLSTALRFTTLPSYIKNPLTMTLTLNPVMGHISAAYSIKAGNDFSLSSRFNFNIFSYESTLDLGFELWRRSQLPESSLSQIPLSSDLAVPLNPRTSIIKLSTGSRKNIRILWEWRYKGLLCSFGAIFDLNSHLSILKSFGFEFQCFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTL2</accession>
    <name>M7NTL2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol-phosphate mannosyltransferase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873251.1">
        <property type="nucleotide sequence ID" value="XM_007875060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTL2"/>
    <dbReference type="GeneID" id="19895022"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01325"/>
    <dbReference type="HOGENOM" id="CLU_2292884_0_0_1"/>
    <dbReference type="OrthoDB" id="2014333at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013174">
        <property type="entry name" value="DPM3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433:SF0">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08285">
        <property type="entry name" value="DPM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="101" mass="11802" checksum="A6355049AFB6EBD6" modified="2013-05-29" version="1">MANLSKPLNSLKHGKLNKIYWGLAFFIISLASWATGRISELITWFFIILFWLLVSIVSFLFGYLGFQLMLFNDKQEAYEIILKDIKEATDWLRQHGIDVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTN7</accession>
    <name>M7NTN7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NudC domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01342</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873271.1">
        <property type="nucleotide sequence ID" value="XM_007875080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTN7"/>
    <dbReference type="STRING" id="1069680.M7NTN7"/>
    <dbReference type="GeneID" id="19895039"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01342"/>
    <dbReference type="eggNOG" id="KOG4379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_467009_0_0_1"/>
    <dbReference type="OMA" id="DTRFVHH"/>
    <dbReference type="OrthoDB" id="428655at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06463">
        <property type="entry name" value="p23_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037895">
        <property type="entry name" value="NUDCD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664">
        <property type="entry name" value="CHRONIC MYELOGENOUS LEUKEMIA TUMOR ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664:SF1">
        <property type="entry name" value="NUDC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="6">
        <location>
            <begin position="279"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="584" mass="67416" checksum="B7AAC8DD070E32E2" modified="2013-05-29" version="1">MNSQVNTARITLKLARNTTLLHPKFESYKLRNDKEILSFYRLEISHKLSKLQIPSYAKIGYYEWKARLGRNHLRPSVKPFCALYISEDGVFVELFMEKIKNEVILKERIIATIHIPKFECRGTGYDDIYPYFPDLKSLTETLILATDGAGKFYFIDSSSDPVQVDMAVFSTEDLESHPFIILDAVYHSNIKIQVLIAHLNGRKEKTNTKSRRYLIKNIMCEKTSTSWELSILNVFFSKEIPIFSQFLGKTLIDQTIVLGVQNRIEDNLQKGYETLREYNEQLHYTWIQTSEDIRLFLTMSPTITKQDISIKFSRNQLEGFNEDNGLKYVLNSKLYHTILPSESTWTLSTTPLFPEQILEICMKKENVGLKWPHIFENNDNILELENLSDRTMVLKNLLSLKSEPISKIKSSDNYIIDYENAETYFLQQFKEDVCIAEISGITIVGSQFTNEKNKTSCLAIKYDVDALIYNIESSNETSLMNLVHSYTFPALSYISSSKISKKYLKYSYTGKFAIIVESGVYRKGHCNSQNLYLYWNVFNNQVNSYQSVIKIQMEALGLCQIGDHEIIILGENEGKPVALLITNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M7NU95</accession>
    <name>M7NU95_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01003</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYC/HAP5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872917.1">
        <property type="nucleotide sequence ID" value="XM_007874726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NU95"/>
    <dbReference type="STRING" id="1069680.M7NU95"/>
    <dbReference type="GeneID" id="19894701"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01003"/>
    <dbReference type="eggNOG" id="KOG1657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1023495_0_0_1"/>
    <dbReference type="OrthoDB" id="1272441at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22908">
        <property type="entry name" value="HFD_NFYC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000017">
        <property type="entry name" value="Ccaat-binding factor complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF8">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="8">
        <location>
            <begin position="81"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="272" mass="31742" checksum="5A05196DED028563" modified="2013-05-29" version="1">MASKEHTCENNKKTRSKNTDFIKKYNPNISFCDTSPITKSDPFSNVYKGLTGHYKNILINYWQNAIKEIENKDYDFKVHPLPLARIKKVMKIDENVKMISTEVPILFAKGCDIFIKELTLRAWIHAKENKRRILQKSDIANAISKSDMFDFLLDIVSKEDDESLKNEKAYMTNISKLNFISKIQNPFINNTDDNFSKTYVTDQISSNNSNIKNERNKLENQSHISNQEIYTNHIYDTQLLYNTMDSSKNKINDQRPVNIIQEYKSTFNINAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUG6</accession>
    <name>M7NUG6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Presequence protease, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Pitrilysin metalloproteinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PNEG_01092</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Degrades mitochondrial transit peptides after their cleavage in the intermembrane space or in the matrix, and presequence peptides; clearance of these peptides is required to keep the presequence processing machinery running. Preferentially cleaves the N-terminal side of paired basic amino acid residues. Also degrades other unstructured peptides. May function as an ATP-dependent peptidase as opposed to a metalloendopeptidase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer and homodimer; homodimerization is induced by binding of the substrate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M16 family. PreP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873004.1">
        <property type="nucleotide sequence ID" value="XM_007874813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUG6"/>
    <dbReference type="STRING" id="1069680.M7NUG6"/>
    <dbReference type="MEROPS" id="M16.013"/>
    <dbReference type="GeneID" id="19894789"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01092"/>
    <dbReference type="eggNOG" id="KOG2019">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009165_0_0_1"/>
    <dbReference type="OMA" id="FPFQVHY"/>
    <dbReference type="OrthoDB" id="10250783at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000013">
        <property type="entry name" value="Mitochondrial presequence protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000009">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000011">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055130">
        <property type="entry name" value="PreP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF13">
        <property type="entry name" value="PRESEQUENCE PROTEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08367">
        <property type="entry name" value="M16C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22516">
        <property type="entry name" value="PreP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16C associated" evidence="16">
        <location>
            <begin position="495"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMR10947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1009" mass="116144" checksum="A3100B43570A5118" modified="2013-05-29" version="1">MDIKRKIIQPFYRNTYVSLFRRKKYGISKGKELPAAGDQLHGYLVERKKHIKELDLTAVLLKHEKTGAEHLHIMKNDRNNVFAIGFHTPPPNSAGIPHILEHTTLCGSAKYPVRDPFFKMLNRSLANFMNAFTCSDHTMYPFATMNPIDYVNLRDIYLDATLFPKLRKIDFLQEGWRLENEDPKDPQSPIVYKGVVYNEMKGQMSNSSYLFYIRYQQQMFKNTIYQNESGGDPAVITDLTHEDLVNYHKKYYHPTNSKFFTYGDFPLDEHLQAINSKISSFDRTIIENVQKSIEPFESPRRIYDIFPFDPLSDPNSQIKMSISFSANDIVNVFETFSFRVLSSLLLDGHSSPLYKRLIETGLGSDWSPNSGYDTSFKTGIFSIGLQGVAKDNIKKVELEIRNVLEEVAEKGFEQHKIDAILHQIELTLKHKSANFGISLMQSLQSGWFNNSDPFLMISINEIITKFREYTRDGQYLKSLICKYMLNNKNSLSFIMMPSKTLMQDLSENETKSLMTKINSLSLQEKKEIQIQALELLKNQETKEDISCLPTLSIDDIAKNVSKVELFHEKIGKLSVQWRIVPTEITYFRAINPLNKLPEHLKPYLPLFAEVLTNLGTHSQTMSDLEDEIKLKTGGLNVSTYISTKYNDLNAIEQGLLFSSHCLSHNIQSMYNLFRKLLLETNFDNVKKLRSLISINNSNIMSSLAESGHSYARAFSASSLTLGGKFSETMSGITQAKLVSKLSMKEDLLSVVDKLKEISKYTFFQESLKVFITCNDKHINLNKKELNKFFLSLPTNLGDDKPEDVFSQFIPSFGRKAFFPLPYSVNFVSLCLLGTPYIHQDGPVMQILSKLLTQQYLHKEIREKGGAYGSGVSYNSLEGIFGFYSYRDPTPQRTLSIFTNSGQWAMEHNWTQKELNEAKLNVFQSLDAPISIDQEGLPYFMNSLSNEMRQQHRERLLQVNVSDLYRVLEKYIFEPISRQHLSVTVLGEKKKWIEQEKQWRIFDLNEDIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7NV30</accession>
    <name>M7NV30_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sm protein F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_00748</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872649.1">
        <property type="nucleotide sequence ID" value="XM_007874458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NV30"/>
    <dbReference type="STRING" id="1069680.M7NV30"/>
    <dbReference type="GeneID" id="19894446"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00748"/>
    <dbReference type="eggNOG" id="KOG3482">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_12_3_1"/>
    <dbReference type="OMA" id="GYMNVQL"/>
    <dbReference type="OrthoDB" id="409625at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990935">
        <property type="term" value="F:splicing factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036261">
        <property type="term" value="P:7-methylguanosine cap hypermethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01722">
        <property type="entry name" value="Sm_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000011">
        <property type="entry name" value="small nuclear ribonucleoprotein F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034100">
        <property type="entry name" value="Sm_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="8"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR11152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="86" mass="9667" checksum="39C32E545E453837" modified="2013-05-29" version="1">MSGFVPINPKPFLQELTGKSVLVKLKWGQEYRGFLQSVDSYMNIQLANTEEFVDGKNTGQLGEVMIRCNNVLWITGNVDCIDLKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7NV38</accession>
    <name>M7NV38_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00593</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR10991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872489.1">
        <property type="nucleotide sequence ID" value="XM_007874298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NV38"/>
    <dbReference type="STRING" id="1069680.M7NV38"/>
    <dbReference type="GeneID" id="19894291"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00593"/>
    <dbReference type="eggNOG" id="KOG2002">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003008_0_1_1"/>
    <dbReference type="OMA" id="EHWLTIA"/>
    <dbReference type="OrthoDB" id="343875at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031101">
        <property type="entry name" value="Ctr9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027:SF2">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13428">
        <property type="entry name" value="TPR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="548"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="672"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="739"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="782"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="905"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="965"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="547"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="910"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="965"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="982"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="994"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1044"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1065"/>
            <end position="1076"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1131" mass="131887" checksum="3AF81ED821E484C6" modified="2013-05-29" version="1">MNAVPTSQDINRQAKIQGKEQRIIEVPLKEQGQLVEIDCTTLPEDAEELCEILECESASKEFWIQFSYEYRRQGYIDQAIHILIRGLKVDMQKENKLPLYSMLAALYLEKARRAPRTEDQKEFSSEAHTKDYYHQMATQALNEANRIDFSFLPNILTRAVWNIMRSSGEKSLIDQAGKYFDDILIADPRNLFAMLGKARILFSRKNYVGSLKLYQTILSSKPDFVLDPRIGIGLCFWKLNMKENAKASWLRSLELNEKNVSANTLLSLYYLDSASSKTGTSEFLEEYEKSLKYAQNAYKQSQTDPYSANILASYFFSKRNMDMTIKLSEKALKYADTNYLINNSLFLMARAYHYMENYEKASELYQHSYSIKDSRVISEIGMGQMKLIQDDIVGAKLIFEKITEQHPKCIEALTILGSIYTHEILSSNSRNDKSLERQKAKSLLERAIHLISNSEQREFSGSGIFITLAALCEEEDNNVSLESYERALDLERNFPTNILPQLLNNIGVLHHIKENFANARQFYQDALNQCVSMGQQENNTINIDALVTTLTYNLARCEEQAKNYEKAKKFYEELLQRHPDYVEARVRLCHMEIIKEGTENLSKKIKNLIEANPGNLDVRAYFGWYLSRQKWNKTSGDNPEQKHYTHTLKYFDKHDRYSLTAMGNIHLRIAQEFRPTTDAEKEKKHKMYEKAVEFFDKALQLDPKNAYAAQGIAIALAENKQHTKALLILSKIRETLKNETVYINMGHCLTEMKQYPRAIEAYELALNEYQNGSDLMTFSALGKVWLQKGKEERNLSALKEALKFTEKALKLQPSNTAIIFNIAFIQFKFAEIARTLPENKRSIEDLKYALENLDNAIKTFSNLANSKYPPYPKEDIQQRANMGRNTTLRQLERAIQQQKEFESNNLAKLDSARQKRKEEQEKRNAEAEALRVSEEKRQKELTEERRLMQEQVKEWAMKKKEEYEMAEHDIERNKDPNDQGKSKKRNKLKKNRQKKIENKESEPFNPETNEHDTHDDEKQEKTISEQPKKRRKLSKINSKREIIDSDDQVENEEKEVPDIYNNKSNTEEHKENTMIEHETSYTVEDKKNNVLEYRTLNTIEHKTDNSMEYEPSEIVEYDTFDLYGTEDNDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVT3</accession>
    <name>M7NVT3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major surface glycoprotein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_00830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11241.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872737.2">
        <property type="nucleotide sequence ID" value="XM_007874546.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVT3"/>
    <dbReference type="STRING" id="1069680.M7NVT3"/>
    <dbReference type="GeneID" id="19894528"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00830"/>
    <dbReference type="eggNOG" id="KOG3544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010455_0_0_1"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021041">
        <property type="entry name" value="Maj_surf_glycoprot_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003330">
        <property type="entry name" value="MSG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02349">
        <property type="entry name" value="MSG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12373">
        <property type="entry name" value="Msg2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006963423" description="Major surface glycoprotein 2 C-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="domain" description="Major surface glycoprotein 2 C-terminal" evidence="4">
        <location>
            <begin position="859"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="817"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1025"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="765"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="834"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="845"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1033"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR11241.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1076" mass="122888" checksum="C1590AAD1B85EDC8" modified="2016-03-16" version="2">MINKIILIAILNLIALIYGNQNVDLSIRSSQKNAVNPSFKDFIIKEDIYTFILKKDYNDENKCKAKLEEYCEELKDIDPELNKVDTNIKEICNSNDKGQKCKDLKPNIQKNLDQLSDDLYIQSQRYVDNINIDKTFLKCLFLSDLNKNILEYCYFLGDYYQRTEHLKLMHEVIFHVVGDSIANYDDFKEKMKEICPILIQQGINFIFGCFQIERSFKELNKYINYSCNSLNINLNDNELQEQCYEKLKSCYFLKNKCEKKCNELKVLCEKKNITYKLPGKDYNPIKPEKTLLKIELEDFYKKMKDKGIYIENLETTLDNILIYMSNIHPGFSESKCKNVFNKSCDFFKFLSPELKELCQDNIEKRCKDASEITYKCRKLKMTLYLAGFSTHFQDDIFGNEIPRDRLSTSFSSREFSDFNTNCFYIAGTCKNRFFEGCKNVNQANSKKLQEQSFIKLIESKLVEEQYNLKSKDEKLKICQKIVMEKCVALANSNIKNFLICLRPKEICLRLEEIIFTLSKDLEQALDQARDFPKEEDCVELKKECEGILKDLGSNNVKCVTLKKRCKYLEVTKELKYDFLKDKSDSLTNIQNCMKALKEKCDRLFKRGTNAFGVSCALPEETCKFMVSEVENHCNAFKNNIEKHDILNKSKNGNETLVEEICILWDPYCDELMENCPDKLKKGDNGNEKGVCLQLKENCRPFFEKLKLEDELTHELKGSLGKDDECKKALGKHCSERKNSGNQKFNSFCNTDKDKDVEEKVCKKLVEKVKEKCPTLESELGKEKDELKKKKDEYEKVKQESEKFSEEVKLLLSRLGKDGQDAGSKVQNTSATEPAAPPGGAPAPAVPGGSAPSGGANTSNVILVRRTFVSGEVSEAEKKAFDETAKALELYLGLKEKCKGLKGECGFRKDCPKCDAVCTEIDKLCEGIEGLKVTPYRTVSLIMREIMTTTMITAATTTTTTTTTTTTTTTTTTATKSIHGGKVTEQCAFPQTTDIWMTSTSLHTSTMTSTSTVTSTVTLTSMRKCKPTRCTSDSSKETETQKEEEKEGKAKQNEGMKMRVPEIVKIILLGVMVIGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWC2</accession>
    <name>M7NWC2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871892.1">
        <property type="nucleotide sequence ID" value="XM_007873701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWC2"/>
    <dbReference type="STRING" id="1069680.M7NWC2"/>
    <dbReference type="GeneID" id="19893738"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00040"/>
    <dbReference type="eggNOG" id="KOG0677">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027965_0_2_1"/>
    <dbReference type="OMA" id="WEDMQHL"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030476">
        <property type="term" value="P:ascospore wall assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051654">
        <property type="term" value="P:establishment of mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10220">
        <property type="entry name" value="ASKHA_NBD_Arp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000148">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000005">
        <property type="entry name" value="Actin-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="390" mass="44777" checksum="E3A1C7756DCAECE4" modified="2013-05-29" version="1">MNEIPIGTVFPFFWQEIMKLTLIVADNGTGFVKVGYAGSNFPDYVFPSIVGRPILRVEEQMIDTPIRDIMVGDEAAAVRNMLQISYPMENGIIRNWEDMQYIWDYTFNEKLKVDTRDRKILLTEPPMNPLANREKMCEVMIEKYDFYGLTTGVVVDSGDGVTHIVPVYENVVLNHLTRRLDVAGRSVTRQLIDLLLRRGYAFNRTADFETVRQIKEKLCYVSCDLTLDHKLSQETSILVESYTLPDGRVIKLSSERFEAPECLFQPHLIGLEQPGIAECLYNTIQSADMDIRSSLFKSIVLSGGTSMYPGFPTRLEKELKQLWLTRALNGDPSRFNKFKVRIEDPPRRRHMVFLGGAVLANIIKDNDNMWITRNDWSEYGTRALEKLGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWC8</accession>
    <name>M7NWC8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">13 kDa ribonucleoprotein-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_00044</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the U3 snoRNP particle. Binds to the C'/D and B/C motifs in U3 snoRNA. Component of the 25S U4/U6.U5 tri-snRNP particle, a subcomplex of the spliceosome. Binds to the 5' stem-loop of U4 snRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871897.1">
        <property type="nucleotide sequence ID" value="XM_007873706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWC8"/>
    <dbReference type="STRING" id="1069680.M7NWC8"/>
    <dbReference type="GeneID" id="19893742"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00044"/>
    <dbReference type="eggNOG" id="KOG3387">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084513_4_1_1"/>
    <dbReference type="OMA" id="IKNQIYA"/>
    <dbReference type="OrthoDB" id="1924699at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21104">
        <property type="entry name" value="SNU13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000002">
        <property type="entry name" value="NHP2-like protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="12">
        <location>
            <begin position="19"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR11602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="126" mass="13801" checksum="5AA5E116000F4428" modified="2013-05-29" version="1">MSCINPKAFPLADTSLTQQILDLVQQASHYKQLKKGANEATKTLNRGISEFIVMAADTEPIEILLHLPLLCEDKNVPYVFISSKAALGRACGVSRPVISASITTNEASDLKQQIQTIKNHIEKLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWG8</accession>
    <name>M7NWG8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP synthase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PNEG_00081</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871937.1">
        <property type="nucleotide sequence ID" value="XM_007873746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWG8"/>
    <dbReference type="STRING" id="1069680.M7NWG8"/>
    <dbReference type="GeneID" id="19893779"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00081"/>
    <dbReference type="eggNOG" id="KOG1353">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010091_2_1_1"/>
    <dbReference type="OMA" id="INQRDNW"/>
    <dbReference type="OrthoDB" id="9805536at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18116">
        <property type="entry name" value="ATP-synt_F1_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1-ATPase_alpha_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.150.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004039">
        <property type="entry name" value="ATP synthase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="entry name" value="ATP synthase alpha/beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a_nt-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009884">
        <property type="entry name" value="PRK13343.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="67"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="13">
        <location>
            <begin position="189"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="419"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMR11642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="549" mass="60156" checksum="56A33EF38948D71E" modified="2013-05-29" version="1">MIASSARMASFFFSGFFKRSALRTISAEYPIIRINTRGFSEKVSPTEISSILEEKIRGISADASLTETGRVLSVGDGIARVYGLNNVQAEELVEFSSGIKGMALNLEPDQVGVVLFGNDRLVKEGEIVKRTGDIVDVAVGPSLLGRVVDALGNPIDGRGPIKATERRRVQMKAPGILPRQSVREPMQTGLKCVDSMVPIGRGQRELIIGNRQTGKTAVALDTILNQKRLNNGNDESKKLYCVYVAVGQKRSTVAQLVQTLEENDALKYSIVVAATASEAAPLQYIAPFSGCAMGEWFRDNGRHALIVYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMNEKYGSGSLTALPIIETQGGDVSAYIPTNVISITDGQIFLESELFFKGIRPAINVGLSVSRVGSSAQVKAMKQVSGSLKLFLAQYREVAAFAQFGSDLDTSTKLTLNRGERLVELLKQNQYSPMPVEEQVPLIFAGVNGLLDKLPVEKIGPFEQAFLAHLRQNFSGLLTKIREEGSLSKETNEEIRTVIEEFLKTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWI1</accession>
    <name>M7NWI1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871947.1">
        <property type="nucleotide sequence ID" value="XM_007873756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWI1"/>
    <dbReference type="STRING" id="1069680.M7NWI1"/>
    <dbReference type="GeneID" id="19893788"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00090"/>
    <dbReference type="eggNOG" id="KOG1587">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012999_2_0_1"/>
    <dbReference type="OMA" id="MHDRPEY"/>
    <dbReference type="OrthoDB" id="366230at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="445"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR11652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="632" mass="72416" checksum="A1536B3C348A4B90" modified="2013-05-29" version="1">MERRKAEIEEKRNKLAAFRRHIQERRGQFELSKASDETMSQVEKKNMFDNKKEIDDLVTRLMADTKIEEKEDLKGEMPLKVEKRETKEKISIQNAYTLSVTPPIHLFNIPPLQQELKPITYNKEIQTSFELNTPPKKEIDIEAQVEIRLKQALDEELQKEEIRRKEEQNIDIKIEILKDEKRNDIFNSTLFQNFIEKSSKIIERVLDEEYQPTIDYSEDYSLSKDKHTEKKIKEVMQFQCEKWTSKKVITDLDWSNHFKELSLASYSKNKGIFSNSDGHVMIWNLHLHDRPEYIFNSQSDILSAKFSPFHSNLIIGGSYNGQILLWDTRANSLPVLMTPLACTGHSHPVYSVKIVGTSNANNIISMSTDGIVCAWTVDMLTQPQEILELTAPSSFKYDDICSRCIEFPESDPTTFLVGTDEGNIYFVNRYNRAGVKAGINPGLIYKGHMGPITSISFHSSKGPLDFGNLVLSSSLDWSIKLWKIKPSTVLNTNHLDKDHNLNSNIPIMEFDCGEMIYDIKWSPIRPGIWASVNGGGSLEIWNLDANTEMPVAQIFPSTTSSTNKALNKLSWESYEGKRIAIGGLDGVVSIIDIGDFGGTEFKQEEWIKMKKLVDKNNNHDRTGSEINEIRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWW3</accession>
    <name>M7NWW3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871946.1">
        <property type="nucleotide sequence ID" value="XM_007873755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWW3"/>
    <dbReference type="STRING" id="1069680.M7NWW3"/>
    <dbReference type="GeneID" id="19893787"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00089"/>
    <dbReference type="eggNOG" id="KOG1379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029404_7_0_1"/>
    <dbReference type="OMA" id="ANTIAWM"/>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="61"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR11651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="338" mass="38197" checksum="D0603B2168398AFA" modified="2013-05-29" version="1">MPFFISFRKPLLNIVKAFSTRSFINQYLPVISVACSPGKKSQTSKIILSSLDNSWETLKKRIRNTSQIDWRFKNIQDSFFVSELKEIGGKKEIAVGIFDGVGGWETSNIDVKCFSWGISEKTENIFKEQTKKEDTIVEALKKGFEEVLMDKNIVGGGATVCLGQFYYEKGNIKIINLGDSGYSIYRNGILLFKSNIQTHFFNAPFQLSKIPLDLLKQSKEGGKTYLKNEVDDADIYNHDLKHGDVIVFATDGVLDNLFFENMEMIITKTLVNAGIWLKSGQNVLPYEGNISKDQLLVATQVSKHLVVSAKKIAQNTKIDTPFAQEARKHHFFYKGGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWY4</accession>
    <name>M7NWY4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL46</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00214</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL46 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872082.1">
        <property type="nucleotide sequence ID" value="XM_007873891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWY4"/>
    <dbReference type="STRING" id="1069680.M7NWY4"/>
    <dbReference type="GeneID" id="19893912"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00214"/>
    <dbReference type="eggNOG" id="KOG4548">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040204_0_0_1"/>
    <dbReference type="OMA" id="HPFENAF"/>
    <dbReference type="OrthoDB" id="414075at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04661">
        <property type="entry name" value="NUDIX_MRP_L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000018">
        <property type="entry name" value="39S ribosomal protein L46, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040008">
        <property type="entry name" value="Ribosomal_mL46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021757">
        <property type="entry name" value="Ribosomal_mL46_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033650">
        <property type="entry name" value="Ribosomal_mL46_NUDIX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L46, MITOCHONDRIAL PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11788">
        <property type="entry name" value="MRP-L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL46 N-terminal" evidence="8">
        <location>
            <begin position="44"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="271" mass="31859" checksum="7568A4E40B5051FD" modified="2013-05-29" version="1">MILFSKLRNGRFFSNFSRISREIDIDEITYHFVPELDQEPPRLYRILAATVLLRSPVITEEKTPFEKAYYAYQRQLNERLAAPFPVDFYFKKGSLAEKKWFDNEANKAKAEFLSDNIYSELQDEKADIALPRETEADRRGDLRSLERKLDKTLYLLVKKPREEHCWQFPQGVVTDDDFLHTAAERSLYEVCGNNMNVWYVGHVPIGNGKYKYPKGYSDKFYGAKIFFMKARVMAGQVKPDGKTVVDWLWVTKDEIKQYVSKPYWNSIQAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7P2J0</accession>
    <name>M7P2J0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NOT2/NOT3/NOT5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_03615</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875688.1">
        <property type="nucleotide sequence ID" value="XM_007877497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P2J0"/>
    <dbReference type="STRING" id="1069680.M7P2J0"/>
    <dbReference type="GeneID" id="19897302"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03615"/>
    <dbReference type="eggNOG" id="KOG2151">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_531125_0_0_1"/>
    <dbReference type="OrthoDB" id="25391at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="366"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="513" mass="57340" checksum="011AE0BE7DDC7E81" modified="2013-05-29" version="1">MNRNGISQQIRPSIGYPSNPNISRKITPISVNNSGRISKGRIQSGSSWTLNPAATFQVLQPHSSSPKFVDTTHLAHSPTVISHSMSSENLTNQMSPLDPSDFPALGTSSNTSLAHASNQYSEYAYSTINEHQKSQALLTRSLLTNTNGFSNNQDDFSSITSGIDMMKLGQKMNNVNAENPYTDAYSSILSPILKQQNTNQAMLSPHRSSLLSTMTSGSASLQKTRKNLSRTNVSSLDMIKDNFISILKPGVQSYNIIGDQEKMNTSKVNPDLLPSVERHSSNSLANLLFSSFPHDASPNTSVMDVKESSAGQTLASLTPVERFSLKGLLSIFKMENPDLNAMVLGSDLTVLGLNLNHSDDRPLYMSFLSPWMDLNTTKAYSVPKFNLPACYNVQLAPPALSKIRNFSDETLFYIFYSMPRDAMQEAAAQELTNRNWRYHKELKLWLTKEPGVEPIQRTPQYERGQYIFFDYILWEKLKKEFLLIYDALEDRFTPFTSNITGEMGFCQRMLNGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3X1</accession>
    <name>M7P3X1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Superkiller protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_03040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875092.1">
        <property type="nucleotide sequence ID" value="XM_007876901.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7P3X1"/>
    <dbReference type="GeneID" id="19896727"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03040"/>
    <dbReference type="eggNOG" id="KOG1127">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001688_2_0_1"/>
    <dbReference type="OMA" id="CQWELDP"/>
    <dbReference type="OrthoDB" id="421075at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039226">
        <property type="entry name" value="Ski3/TTC37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040962">
        <property type="entry name" value="TPR_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704">
        <property type="entry name" value="SUPERKILLER 3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704:SF7">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18833">
        <property type="entry name" value="TPR_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="670"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="951"/>
            <end position="984"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1363" mass="157472" checksum="A623FDF45120A81E" modified="2013-05-29" version="1">MAKPALKASKEFITAKDYKNAIIYAKKALDFDPFNYNAYVFLGIGYFNVSEFDECENAYKKALEIDKEAYLAWKERIYTGFSCLYASQNRVDEYIYASVKLASIFMKSDEKDKCLESLKKLLEFVEERGSLNQILKTLKFYLPSGPFYKYIENCIITAEIAYIKMIKIAEDLEREKINKSMAKQRGRLGFTAEEISRNVKKEVFKDSTLEKIYEEAMNWIDDDKLRREIEVKLLNHCYEHLKIVDANEKNYKREKVLKLASGMVIVKSYDILPWMIVLEWKDFEEIDELDIMFIQDFISLFPKHPMGLCLRGVLSLYLKYSKRTFVNGGSENNSDYILKNISCELFDDPLDVFIEATENLPNSVFCYRFLVRSYLSIKEYENAVIVSQEGLKALSKFSEETGLSLPFAQRDLKFHLALSYVHYKFPKFHDKALELFDQILELSCNNVMSLYGKAIILEEKKDFSSSIDLLLKAKDMDPNNILILSEIAWCEINTKNYEDGLNKLDICIEKMNSDISLSGYDKAEICWKKGVGLFEQNVESKKSESYSFFITSLKYDPTYSHSYVNLGIFYADILKDESRSMKCFQKAFELNAGEVDAAERLVVAYAKKGEWNLVEAIAKIVLSADKIYRRYSRDLSWPQRSLGIVEMNYKRYNSAIVYFQSALKICANDSHSWSGLGEAYAKSGKYIAALKALKKSRSLDEDNWFVQYLIGDVQKTLGLYKDASESYYSILELHPDEFVVTLALSENYVFWASSWKEKGFYKKSEEYAINCFKIIELSKSNSKKNSYTLWIILSRACFLLSSFFVVDSESLISILNILYEEYDFVGEKLVPIIDDLPLDKKDLFDNNNSRYLLLWAFLFMKRAVRVSVKNRAAHSMSWYSLGQILFLIYLRNVDADGDWIHCSIYCLKRAIKMDSKNSTFWRAFGVVNSTLNSKISQHALIKSLKLDDQNPITWADLATLYMINEDFDLAYEAYMKSQTVDPDYWVSRIGLGFISKIMGDTLEAKEQFEISFINSSQNIPIVNYLFVTSSYDYLKKTSLSELTGNLTTYVFAIQKYLEQRPTDCNVLILMSLLLEMSYDWTKCILFSSKACDILEKEYEGNENSEIIVQFLHAKSSLSRAFLANKQYEMALENAQIVLNLTEGSEASSNRLSCYLVASISLFYLNRIMDALEMFQNSLTEFNEHPDIIVLLCKILWATGGQEERDIARQQLFECISQNSNHISSLLLLGSIGILNQDIEVEATTLKCLHALDWDERKKHDIDHNVERYLELSAYLKGNDPKYIYLSALNIYPSSPIIWSRLALLENSPDVSLMALQITLKNPCSPEILASAYHQMLTIFDCLKALHLAPWLPKHWRTLEKLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7P4B6</accession>
    <name>M7P4B6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">60S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02868</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 33 different proteins. The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and at least 46 different proteins. eL20 forms multiple interactions with RNA and proteins in the central protuberance, connecting components of core functional centers that are located far apart.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874905.1">
        <property type="nucleotide sequence ID" value="XM_007876714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P4B6"/>
    <dbReference type="STRING" id="1069680.M7P4B6"/>
    <dbReference type="GeneID" id="19896555"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02868"/>
    <dbReference type="eggNOG" id="KOG0829">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080773_1_1_1"/>
    <dbReference type="OMA" id="CIFAKND"/>
    <dbReference type="OrthoDB" id="1294322at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_eL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="Ribosomal_eL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_eL20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021138">
        <property type="entry name" value="Ribosomal_eL20_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10052">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002190">
        <property type="entry name" value="Ribosomal_L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160374">
        <property type="entry name" value="RplX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL20" evidence="6">
        <location>
            <begin position="8"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00063225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="178" mass="21441" checksum="F8E8B7F2D877BC96" modified="2013-05-29" version="1">MTIKPHFTEYQVIGRRLPTEKEPVPKLYRMRIFAPNTVVAKSRFWYFLKKLRKIKKSAGEIVSLNVIYEKRPCKVKNYGIWLRFDSRSGTHNMYKEYREVSRTAAVDALYQDMASRHRLRFRSIQIIRVVELKKTCDVKRSYIRQFLDTKIKFPLPHRYPKSFTKRTVFLAKRPSTIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7P594</accession>
    <name>M7P594_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02822</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874856.1">
        <property type="nucleotide sequence ID" value="XM_007876665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P594"/>
    <dbReference type="STRING" id="1069680.M7P594"/>
    <dbReference type="GeneID" id="19896511"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02822"/>
    <dbReference type="eggNOG" id="KOG2884">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033293_1_0_1"/>
    <dbReference type="OMA" id="QMSMQDQ"/>
    <dbReference type="OrthoDB" id="1731724at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01452">
        <property type="entry name" value="VWA_26S_proteasome_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="5"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="234"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="274" mass="30597" checksum="0FADA10B90415572" modified="2013-05-29" version="1">MTLEATMIVMDNSEFARNGDYLPTRFGSQKDAINLIFSAKMRAHPENMIGLMSMGGKGPEILVTLTQDYGKFLAAMHESKIGGNSNICTSIQVAHLALKHRPEKRQRQRIIVFVGSPVTEDEKTLVKLAKKMKKNNVSVDFVYFGEICEENTAKLNAFIEAINSDNNSHLTTIPPGPRLLSDQLLYSPIIATDRASMHSTSNIQGGFPSEHFDFGVDPNLDPELALALQMSLQEEQARQEVQEGRSRENNTELSNHTIQKDSTQENTEKMDVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7P680</accession>
    <name>M7P680_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874309.1">
        <property type="nucleotide sequence ID" value="XM_007876118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P680"/>
    <dbReference type="STRING" id="1069680.M7P680"/>
    <dbReference type="GeneID" id="19896003"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02310"/>
    <dbReference type="eggNOG" id="KOG2444">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035848_0_0_1"/>
    <dbReference type="OMA" id="QAIHPTE"/>
    <dbReference type="OrthoDB" id="2288928at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22652">
        <property type="entry name" value="NUCLEOPORIN NUP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22652:SF0">
        <property type="entry name" value="NUCLEOPORIN NUP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24796">
        <property type="entry name" value="WDR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="335" mass="38336" checksum="19B12CE294104459" modified="2013-05-29" version="1">MCLILDSELFALRTHPFQPLLTVGTLNGRISSYHFNLNEKTYDQVWHTYRHRIACRDLRYSMNGEEIISVGADGMIKYAKSDTGRVIWKVKNAHMNAINVVCYLSEMSFVTGDDYGLIKLWDKRSKECIKEVNAHKDYISSFLRLDEMVLLSTSGDAFFSILDFRIVKCLPVFSYDFGEDLLSSCLVKSETIKPKICIGTASGMIKIFNKGEWDNHTSQILLSKKKHMLSVDIMMAWNDDIIVASGNDGVIRVLNIHPNIPLGILGYQDSSIDVLAKTYDNDWILSGGDKKIIAWKANWNDNFKKHNKFNQDTSDQARKKKLMLDKDMSFFKDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7P696</accession>
    <name>M7P696_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mannosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_02327</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 22 family. PIGZ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874329.1">
        <property type="nucleotide sequence ID" value="XM_007876138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P696"/>
    <dbReference type="STRING" id="1069680.M7P696"/>
    <dbReference type="GeneID" id="19896020"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02327"/>
    <dbReference type="eggNOG" id="KOG4123">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022957_2_0_1"/>
    <dbReference type="OMA" id="GIMHQNG"/>
    <dbReference type="OrthoDB" id="10066429at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF3">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="304"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR09380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="514" mass="60489" checksum="8E03D22866F55244" modified="2013-05-29" version="1">MKFLIFCGIYICLVLIRLGFSISESYIHPDEHLQGIQVVAGNILNIKVEYPWEFKGQFPIRSIGPLLIIYGLPLKISQWISGDTPVNPLFIFFLLRVFFFGLSFFIGRKFFKWRELFYNDEDWFIYTSTPLKYRRKALLIYASSFVTWTYQTHTFSNSIETIMVSICLFLIQKIKMNIRPWKCVLLAIFSSFGFFSRITFPIVLLPFVASFSKSLIKRPKIIFSIIKSFMLMFFIFILIDSFYYANGYRVIITPLNNFKYNSKYINLQKHGIHSYWTHFLINVPILLGPAIILPIIVKNIKFNLYLISSVLYILILSLFPHQELRFLLPVFPLLIIYLSSLGNIRKKKIRYLFIFSWIIYNIFFGIFLGFFHQHDVISIIFFLKKYLVNDSSANVVFWKTYPPPTWLFLDPPDSKIIFSHLIGYSVNNVLDYLSIKKQNGVKSIFIFPTLLIEKLPCVFEELRNSSCKTNVTLRQIFKTSYYIGLDDSDFINNNIFFVLMDLIRKKGLVVCEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6N9</accession>
    <name>M7P6N9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PNEG_02136</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874117.1">
        <property type="nucleotide sequence ID" value="XM_007875926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P6N9"/>
    <dbReference type="STRING" id="1069680.M7P6N9"/>
    <dbReference type="GeneID" id="19895829"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02136"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002664_0_2_1"/>
    <dbReference type="OMA" id="NSADYRP"/>
    <dbReference type="OrthoDB" id="1928777at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902716">
        <property type="term" value="C:cell cortex of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140472">
        <property type="term" value="C:cell cortex of non-growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035841">
        <property type="term" value="C:new growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035842">
        <property type="term" value="C:old cell tip after activation of bipolar cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051523">
        <property type="term" value="P:cell growth mode switching, monopolar to bipolar"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902408">
        <property type="term" value="P:mitotic cytokinesis, division site positioning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903500">
        <property type="term" value="P:negative regulation of mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12121">
        <property type="entry name" value="MARK_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14077">
        <property type="entry name" value="STKc_Kin1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001222">
        <property type="entry name" value="Serine/threonine-protein kinase ppk25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="77"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="15">
        <location>
            <begin position="869"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="713"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="716"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMR09550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="918" mass="104336" checksum="0A698409EC416BC5" modified="2013-05-29" version="1">MISVERVSRNMKEPEKIVTSMVSSPSNASTSNQKTQEPEAGITQKRSPKVGGSRSGSKEDHILSKERAYIRKTIGDWQLGKTLGSGSMGKVKVVTHMTTNEIAAVKIIPRPFSQGISITSQNVDYGKEIRTIREIAISSLLQHPYICTLRDVKIQPNHYYVFFEYINGGQMLDYIISHGKLKEKQARKFARQIGSALDYCHRNSIVHRDLKIENILISKEGDIKMIDFGLSNLYSPHSQLSTFCGSLYFAAPELLNAKAYTGPEIDIWSFGVVLYVLVCGKVPFDDQNMPALHAKIKRGHVEYPSWLTIECKQLLSRMLVTSPSQRATLSEILNHPWMTRGYDCPPNNYLPPRFPITFPLDMEIIRRMTGFEFGNEQTILAKLTNILESEGYRKLVKAYYSQPQDTHVLSLLMDKKKNFFDFYKRKISSSPSSSSFTPDVNQHPPKTKPIYIDAYHPLISIYYLVKEKIEREKKCNYQDSYIHGNDHYETSNSCTPINTNLSLLDYKNYHSTIPPIRKQSFAPRARARTYDEKEVAKAIKNISPISPNTVDNHRLIKESKEKNFKIFRRFSSKRIKKHFSSPTSILPSLIPVELLTSPPKSLSNKYSHDLEFLQETDAKIQLNNHFSNGTNLKRSISVNDNAYLSKHISPPPPIHNPSISKIYLKDLKKNTAMENGIQPSPRSSNIASTFSFKGSRTKSLGHTNSEVLRKEKKCQRQSSVLVKRNSPTTPVNSNKYISNHACQPLNSTQPSHEVTVKSGFLKGIFSVSTTTSKPPHIIKSDLIRILNCLNISFRDIKGGVFCIYQPSINLKDLINNTVEPNHHVFTPITHLKRSISLHKMNFEKKKTGIDIHSYTVASESDDSFDNGKNKHTNFTIQFEIYIVKVPLFALHGLQFKRVGGNAWQYRSLASRIIAEMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6S3</accession>
    <name>M7P6S3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874152.1">
        <property type="nucleotide sequence ID" value="XM_007875961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P6S3"/>
    <dbReference type="STRING" id="1069680.M7P6S3"/>
    <dbReference type="GeneID" id="19895863"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02170"/>
    <dbReference type="eggNOG" id="KOG0724">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019916_1_0_1"/>
    <dbReference type="OrthoDB" id="1690618at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006452">
        <property type="term" value="P:translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.840">
        <property type="entry name" value="Ribosome-associated complex head domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032003">
        <property type="entry name" value="RAC_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042569">
        <property type="entry name" value="RAC_head_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044634">
        <property type="entry name" value="Zuotin/DnaJC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16717">
        <property type="entry name" value="RAC_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="98"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="293"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="435" mass="51533" checksum="0EE2636EF2C6D51C" modified="2013-05-29" version="1">MGTCREVIDAIEEKNEEDLYELGIFKAIEGINKWEIREIEGAGSHFLKYAEKKLNKELLNKNFVEKKEEKIKFINEEEEEEEDLELLRSDPKEWKQQDHYAILGLSKSRYKATLEEIKQAYRQKVLKHHPDKKAAQGNLNDDSFFKCIQKAMEILSDPIKRRQYDSVDEKANICLPSKKDTTCFYKQWNEVFESEARFSNQHPVPSLGNEYSTKEEVEKFYNFWYNFDSWRSFEYLDKDIPDDSYNRNNKRYQERKNKADRTKRKTEDTARLRALIDTCLSLDPRIKKFKQEEKAAKAAKKQESRTNAQETHEKLIKEEEERKKKEMEEQLRKEEKKAKEIQKKAIKKNKKIIKQSLKTANYFYTGENVPLDVIDNVLADAELILQKIPLEQMTFTKALEETTQAENIHAIFKACIKKLIEEKVIEVSDLKVLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6U5</accession>
    <name>M7P6U5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">5'-3' exoribonuclease</fullName>
            <ecNumber evidence="15">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PNEG_02193</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Possesses 5'-&gt;3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Possesses 5'-&gt;3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote the termination of transcription by RNA polymerase II. Essential for vegetative cell growth and chromosome segregation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with RAI1; the interaction is direct, stabilizes RAT1 protein structure and may stimulate its exoribonuclease activity. The interaction also stimulates RAI1 pyrophosphohydrolase activity, probably by recruiting it to mRNA substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="15"/>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874177.1">
        <property type="nucleotide sequence ID" value="XM_007875986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P6U5"/>
    <dbReference type="STRING" id="1069680.M7P6U5"/>
    <dbReference type="GeneID" id="19895886"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02193"/>
    <dbReference type="eggNOG" id="KOG2044">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006038_1_1_1"/>
    <dbReference type="OMA" id="ITHDMVV"/>
    <dbReference type="OrthoDB" id="28245at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051984">
        <property type="term" value="P:positive regulation of chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180037">
        <property type="term" value="P:rapid tRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1050:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000003">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000005">
        <property type="entry name" value="5'-3' exoribonuclease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017151">
        <property type="entry name" value="Xrn2/3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF41">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037239">
        <property type="entry name" value="Exonuclease_Xrn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 15" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 15" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="16" id="KW-0862">Zinc</keyword>
    <keyword evidence="16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="18">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMR09610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="964" mass="112042" checksum="6C073A51A9EF2FE7" modified="2013-05-29" version="1">MGVPALFRHLSRKYPKIITQVIEEKPIDIDGTLIYPSFSHPNPNGTEFDNLYLDMNGIVHPCTHPEDKPAPKNEDEMMIEIFKYTERIINIVRPRKLMMMAIDGVAPRAKMNQQRSRRFRAAQDAEKKAADIEEFIKLLKASGKPIDEISKKKEIWDSNVITPGTPFMDTLARSLRYWIIYKINVDPAWKDLKVILSDATVPGEGEHKIMEFIRSQRCNPGYDPNTQHVIYGLDADLIMLGLATHEPHFRVLREDVFFQDSNSKGCHICGQNGHFARECTGIRENNEIVNEKQNNPLPKPFIWLRIDVLREYLEAELNIPNISFQFDLERAIDDWVCLCFFVGNDFLPHLPSLDIYEGAIEILGNIWKDKLHEMKGYLTMDGHIDLKRAEIILQALGQQESHIFYKRHEAEKRLNESNKRRKIDKNSPQDYKKSVSQEKTPLYDNNLKNIGKRTSNSRYIPYLPNDLIIPSNKEDVKMITVTNRNAVLNRKNLKMTNDINKCAAKLLKEKMNDNDFEKNQNIDLYDDLNKSYNRNCTIDSESSILGKRKAIVLDDTLKQDSMIHDDNSDDIEDTIRLWEPGFQERYYDQKFHISESDIESRKRIVEHYIKGTCWVLLYYYQGCPSWNWYYPYHYAPFASDFKDISLLNIKFELGKPFQPYEQLLGVLPASSKASLPKPLQSLMTDEDSEVIDFYPKEFPIDMNGKKFSWQGVALLPFIDEKRLLNAIEKVYPQLSDEEKSRNTVGNDILFISEDNSLYNDLVLSLYTKKKGPEEFIKLNTKLSNGLSGIVLPDKNWIPNSTLFSPLTYVSFPDIENDKSMSLIYKISKSSNIHKSMLLRGVKLNKKFLDINDIRLVRLGLSAQKNYNSLHYSGYIDVNNIPLKQYTKTSKININSSANTISFYNQSDKNEYHNNFNICNYKKYHNNISQFPLPYPNNFNKIDQNKSLWLKEYSAKSDNYKSYPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6W1</accession>
    <name>M7P6W1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-splicing factor SYF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Pre-mRNA-splicing factor syf1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_02209</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle progression.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874192.1">
        <property type="nucleotide sequence ID" value="XM_007876001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P6W1"/>
    <dbReference type="STRING" id="1069680.M7P6W1"/>
    <dbReference type="GeneID" id="19895902"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02209"/>
    <dbReference type="eggNOG" id="KOG2047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007736_0_0_1"/>
    <dbReference type="OMA" id="IWYNYLR"/>
    <dbReference type="OrthoDB" id="10067343at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000023">
        <property type="entry name" value="Pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000137">
        <property type="entry name" value="Pre-mRNA-splicing factor syf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000038">
        <property type="entry name" value="Putative pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056350">
        <property type="entry name" value="HAT_Syf1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23220">
        <property type="entry name" value="HAT_Syf1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="14">
        <location>
            <begin position="26"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor SYF1 central HAT repeats" evidence="12">
        <location>
            <begin position="187"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="13">
        <location>
            <begin position="398"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR09625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="813" mass="96342" checksum="C1443780F8CBFBB1" modified="2013-05-29" version="1">MAQALLNNNKKKILSSNIDSCLISEEDFEYEKELLRNPFSIKSWLRYIEHKEGDPIHQQVFVCERACMDLPRSYKLWRLYLNLRKCHVEGLNPAKYEEEYEKVNVCYEKALVLLNKMPRIWMDYLEFLMKQCKITKTRRTFDRALQTLPVTQHERIWKLYKEFSRSVSGETAVKVWKRYIMIFPEMIEEFIQLLLDMEYYTEAAFQYMALLNNPKFQSLEGKSNFHYWVEFSKLITTHGDKIDGILVEKIMRSAIRRFTDQQGSFFTSLATYFITIGDFEKARDIFEEGMTTVVTVRDFTQIFDAYAEFEESIISQTLEEMEEGHKSKDTNSNDDLDLDIKMIRFEQLMDRRPFLVNDVLLRQNPYNVIEWEKRVGLWGNNNEKIIETYTNAIKTIEPKKAVGKLSSLFINFAKFYEQNNDLNTARLIMEKGVMVPFKSVNELSEVWCEWAELELRSNNFDQAIKIMKKATNCPERSNVDYFDETLTPQQRIHKSSKLWMFYVDLEESVGTIDSTRAVYDKILSLKIATPQTIVNYANFLEENKYFEESFKIFERGVELFSYPVAFELWNLYLTKFLKRYNGTKVERTRDLFEQSLKGCPPNLSKPIFLMYGDFEEKYGLMRHAMRIYDQATETVSTEDRADMYKYYITKLAINYGLTSTRPIYEKAITYLPDKEAKDMCLKFAEMERSIGEIDRARAIYAHASQFCDPRIEPSFWKIWHEFEVKHGNEETYAEMLRIKRSVQAEYNMNISYIPNQTTTHFTSETLESNNDPMASLEKSGILSGFVREVEIYYLYIYSYKNTAHLQVLLEIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7P716</accession>
    <name>M7P716_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA methyltransferase 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01868</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873841.1">
        <property type="nucleotide sequence ID" value="XM_007875650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P716"/>
    <dbReference type="STRING" id="1069680.M7P716"/>
    <dbReference type="GeneID" id="19895562"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01868"/>
    <dbReference type="eggNOG" id="KOG0838">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021322_5_1_1"/>
    <dbReference type="OMA" id="YSNDIES"/>
    <dbReference type="OrthoDB" id="270651at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18105">
        <property type="entry name" value="SpoU-like_MRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047182">
        <property type="entry name" value="MRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047261">
        <property type="entry name" value="MRM1_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00186">
        <property type="entry name" value="rRNA_methyl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103:SF1">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="RNA 2-O ribose methyltransferase substrate binding" evidence="10">
        <location>
            <begin position="68"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="348" mass="40044" checksum="06DC0B63A1C6FC2F" modified="2013-05-29" version="1">MNIRYGFRTIRNSFKTKKKTYFDIKKIYLNKNLIYEYSSNKKYSINQLITGSIREKHRKDEKKVPKEYIYGRSPVFSALIAKNREKFYKLYIYGDDKKNDDILKISTSMSIPIEFVKSKSILDNYSLNRPHNGFVLETSPIRCISLTTRKELLDFQINYSNDIESKISNNLYSKNDLNLWLFLDEITDPMNMGAILRNAYYFGLNGVVLSEKNSASLSPIVNKASSGACEFLKIFKTANPLSFLQLLKSNNWKVIGTTSLSDKVKNDLVIPYNELDTYLSNSPVLLIMGNEHRGMRTLVKNKCDFLVTIPPSQFTFSLIDSLNVSVASGILISELSKILRIKKYDKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7P7Q6</accession>
    <name>M7P7Q6_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GET1</name>
        <name evidence="10" type="ORF">PNEG_01651</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the WRB/GET1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873612.1">
        <property type="nucleotide sequence ID" value="XM_007875421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P7Q6"/>
    <dbReference type="STRING" id="1069680.M7P7Q6"/>
    <dbReference type="GeneID" id="19895345"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01651"/>
    <dbReference type="eggNOG" id="KOG4253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089418_0_1_1"/>
    <dbReference type="OMA" id="CGMFTAF"/>
    <dbReference type="OrthoDB" id="69461at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03113">
        <property type="entry name" value="Get1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028945">
        <property type="entry name" value="Get1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027538">
        <property type="entry name" value="Get1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650:SF1">
        <property type="entry name" value="GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650">
        <property type="entry name" value="TAIL-ANCHORED PROTEIN INSERTION RECEPTOR WRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04420">
        <property type="entry name" value="CHD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="topological domain" description="Lumenal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="3"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="173"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR09890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="203" mass="24127" checksum="A7A0BEB85D74A651" modified="2013-05-29" version="1">MSLLFVCFVIVVVVNFISFLGIDVISSLIFTIYSNFSPYELSSIIRRYRLLQRSALQTKKELSNTSSVDEFAKWAKLKRKYDKEISELEKSTAEMNNQKYYFNIRMRIIIWLCTNGLQYIIQWYYRKIPVFWLAKGWFPHYIEWILCFPMAPIGSVSVSIWFFVANHVVSETFCIIKNCFFENQVKRNINSKIHSSIMSEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7P7W0</accession>
    <name>M7P7W0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01713</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TFP11/STIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873677.1">
        <property type="nucleotide sequence ID" value="XM_007875486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P7W0"/>
    <dbReference type="STRING" id="1069680.M7P7W0"/>
    <dbReference type="GeneID" id="19895407"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01713"/>
    <dbReference type="eggNOG" id="KOG2184">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007977_2_0_1"/>
    <dbReference type="OMA" id="CEQDIIQ"/>
    <dbReference type="OrthoDB" id="4822at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022783">
        <property type="entry name" value="GCFC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022159">
        <property type="entry name" value="STIP/TFIP11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024933">
        <property type="entry name" value="TFP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045211">
        <property type="entry name" value="TFP11/STIP/Ntr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329:SF1">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07842">
        <property type="entry name" value="GCFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12457">
        <property type="entry name" value="TIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017706">
        <property type="entry name" value="TFIP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="G-patch" evidence="10">
        <location>
            <begin position="178"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="78"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="132"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="848" mass="99055" checksum="3139752F93323F19" modified="2013-05-29" version="1">MASYSSSSDENSEENIEDLDLEDQEEFGLFLKHRKRNYKGNTKEDRMLGVFMDDSDEDYNGIGEKQLRYKHVRFTTPKHIDNIYQENKGYSDKKSTEESEKDSSSKYGHFSYVYKPRTEALNDQQAFYSSKQYKTVKVEEESNPQRPFKSTIDLSSSSSASKNKPKLVNSETSKYFKNSGFGAKMLEKMGYVAGQGLGSQGQGILNPVETKVRPTRAGLGLIKEKTQQAIEESRRRGEISEDEEDLPIKKPVHERKSEKVHKEKIKYKTASEIAGGMEVPPVLQQIIDMTEKEVKLIENVSGTMSIPMTLSRNDEMYQISLMARRDLEMYATEWKQLQDRKVYIEMEELRINEDAKKESVKIEKLEKIIKEIEDIYLFCKNNSEDSLELLNNISGMLEEIQHKFFEEIKIYNLDEVIISILFPIVKSLFLSWDPLEKPSPVLNFFHKWKQIIGVKNISEIDQEDDSFSLKQTIMTPFESMLQYLWVPKVRSAINNTWNPYNYSSALLLFESWKNLLSPFIQDFVLNQLILPKLQKSIFNWNPRNFIKKKSSRLPHVWLFPWLPLLKENTETLIDVVKRKFRMILSSWDIKDGPIEELNLWKEIFGDAQFEKLMLNYILPKLSACLRLDFFIDPSDQKLEPLEWILPWRSFFKPSVFDQLFATEFFPKWMDILYLWLTDPECNYTQVSEWYQWWQQVFPPEMLEMPMIRESFINGLDMMHQALNLGNDVSEKLLPPVTNLTQPIEIETKETPLPKTYSKKLQDEDVVFKDVVEDFCLEHDLVLIPLRKAHEDTGNPLFRITASASGTGGIIVYIKGDVVWVQNVKNKNEFSPESLNYILTLAQKSSCRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7P8D0</accession>
    <name>M7P8D0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TatD family hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01413</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873349.1">
        <property type="nucleotide sequence ID" value="XM_007875158.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P8D0"/>
    <dbReference type="STRING" id="1069680.M7P8D0"/>
    <dbReference type="GeneID" id="19895110"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01413"/>
    <dbReference type="eggNOG" id="KOG3020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YGGSQKH"/>
    <dbReference type="OrthoDB" id="6079689at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01090">
        <property type="entry name" value="TATD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005902-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="36112" checksum="16749E41A8C519E5" modified="2013-05-29" version="1">MLKPANLSRSLKSMQRYFDIAFNATDPVFKGIYRGKRAHPNDFNEILLRAKDIGCCQMMITGGCLKDSKEAFELAQQYPNFTSTVGCHPTRVTEFEKYPEGPEEYLKEIHKLALFGKKLRKVVSFGEIGLDYDRLEYASKELQTIYFEKQLSIASKLDLPLFLHSRSAADDFIAILSPYLLQLPRKGCVHSFTGTLEEMRHYISLGLSIGINGCSLKTQENLKVAKEIPLEYLMLETDAPWCSISPTHASYPYIEDTPYIFSAQKKDKFILGKMVKGRNEPCTIIQVACVISRLKGLSIEKVSEAAYLNSIKMFGNQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7P988</accession>
    <name>M7P988_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine desulfurase</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_01130</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. Plays a role in both tRNA-processing and mitochondrial metabolism. Involved in the 2-thio-modification of both 5-carboxymethylaminomethyl-2-thiouridine in mitochondrial tRNAs and 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) in cytoplasmic tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(sulfur carrier)-H + L-cysteine = (sulfur carrier)-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873045.1">
        <property type="nucleotide sequence ID" value="XM_007874854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P988"/>
    <dbReference type="STRING" id="1069680.M7P988"/>
    <dbReference type="GeneID" id="19894827"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01130"/>
    <dbReference type="eggNOG" id="KOG1549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_0_2_1"/>
    <dbReference type="OMA" id="KGLYWAR"/>
    <dbReference type="OrthoDB" id="10250117at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070903">
        <property type="term" value="P:mitochondrial tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000003">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000002">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00331">
        <property type="entry name" value="Cys_desulf_IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02006">
        <property type="entry name" value="IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010611">
        <property type="entry name" value="PRK14012.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="12">
        <location>
            <begin position="55"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR10415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="452" mass="50938" checksum="81990E58B2DCE43A" modified="2013-05-29" version="1">MHWHSFFSRPSKCILKQKLWNKLIRRLSGELIRNEGKTCRIGDSISRRSVGTRPIYLDAQATTPVDPRVLDAMLPYFTYLYGNSHSRTHAYGWETDKAVQKAREHVADLIGADPKEIFFTSGATESNNMIIKGVTHFYRSTKRHIITAQTEHKCVLDSCRVLQNEGFDVTYLPVNKYGLISLEDLERAIRPDTVLVSIMMVNNEIGVIQPIEEIGKICRDKKVFFHSDAAQAVGKIPVNVDKCKIDLMSISGHKMYGPKGIGASYVRRRPRVRIEPLINGGGQERGLRSGTLASPLIIGMGEACRIAKEELEYDYAHVSRLSKRLISHLTQLEYVYFNGDPLRRYPGCINASFAYIEGESLLMALKDIALSSGSACTSASLEPSYVIRSLGVPDDISHSSLRFGIGRFTTDAEIDYICNIIKDKVKFLRELSPLWEMVQEGIDPSTIKWSYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7P9G5</accession>
    <name>M7P9G5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873139.1">
        <property type="nucleotide sequence ID" value="XM_007874948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P9G5"/>
    <dbReference type="STRING" id="1069680.M7P9G5"/>
    <dbReference type="GeneID" id="19894918"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01221"/>
    <dbReference type="eggNOG" id="KOG2940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046586_0_0_1"/>
    <dbReference type="OMA" id="ITRPMDN"/>
    <dbReference type="OrthoDB" id="16816at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050602">
        <property type="entry name" value="Malonyl-ACP_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090:SF1">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="40927" checksum="E42528A8FC6EA45A" modified="2013-05-29" version="1">MFGFSAFKKNSMFFFSPCFHLHKKNHYFRFSLNQICRLKICLRNYLPFTVKSSKKFLVFDQNAKKKQRLRAAFDKIEAKKADYLKKEVAKRLVERLMFIKKKTKVIFDFGSGAGYIASCLSQEKNKDQFLGKIERLIMADVSEDVFDDDNLSNICDFIVEKVYINNEIPSFSENSMDIVITNLYIHWINDLLGLLKQIKYILVPDGVFLGSMFGGDTLFELRTSLQFAEQERKGGIGARVSPMADIQDIGSLLSKVGFKLITIDVEDIIVDYPDIFSLMKDLQKMGENNAIITRPHIISRDVLFAAEAIYREFYGNENGTLPCTFRVIYMIAWKPSPNQSLPLERGTGKINLKDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAF2</accession>
    <name>M7PAF2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00962</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872875.1">
        <property type="nucleotide sequence ID" value="XM_007874684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PAF2"/>
    <dbReference type="STRING" id="1069680.M7PAF2"/>
    <dbReference type="GeneID" id="19894660"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00962"/>
    <dbReference type="eggNOG" id="KOG0601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_412266_0_0_1"/>
    <dbReference type="OMA" id="EQPHTPC"/>
    <dbReference type="OrthoDB" id="5337378at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110031">
        <property type="term" value="P:negative regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14052">
        <property type="entry name" value="PTKc_Wee1_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000536">
        <property type="entry name" value="Cyclin-dependent kinase WEE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF196">
        <property type="entry name" value="MITOSIS INHIBITOR PROTEIN KINASE SWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="354"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="666" mass="74969" checksum="186843B0E00243FC" modified="2013-05-29" version="1">MYASEQTRKRPSLGRSSNRLGSTFRVPFLRTRKHIETDGEVERSTVVSHSVKTPLATESTELNLQFGRSPLKRSERVLIDSTFVSPIAKRNARFVSSVTTPKHLTNSILNHSKGFELTTPNPTNKLRKHVSVENFIAPILKESPFISNKQSSAFYSAFFSNGKQPHPLSHTEMAEEIPGIKGGMSISTRQTFCTPQDYRLVKPLQTVFMSTGLLSKRNRPHSGTSILPPETPCKRSVTFDVLQTPVTPVAGPTDTSFSSQEESFEGIDLSFLYNSSSSEFDCPLTPTKGIFLDSERFGKRWKIDSNPTDLSFFHLSKVPEHGILSDTQSLTIPSNCMSLKKLDPPSPSLLTSRFRNVELVGSGEFSQVYEVQERDGSSKFAVKKTKFAYSGLKERHRRLEEVNILRKLGTHEHIVKLLDSWEQSRYLYIQMELCDNGSLDIFLQEYGRLAKLDEFRVWKVMTELLLGLSHIHDSGYIHLDLKPANIFISFEGILKIGDFGMASEWPVPEGTEREGDREYIAPEVLSSQQYDKPADIFSLGLVILEVAANIVLPQNGVSWQKLRSGDFSDAPCLSSKIYSIVQKDISVPQEQSEHRYIGQGGLDRIVKQMLAPKPSDRPTAKQILETEEVTWVNKVRKAGAIIYEGDYGPIIYSTNDDKNQNWHPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M7PB84</accession>
    <name>M7PB84_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_00746</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872647.1">
        <property type="nucleotide sequence ID" value="XM_007874456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PB84"/>
    <dbReference type="STRING" id="1069680.M7PB84"/>
    <dbReference type="GeneID" id="19894444"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00746"/>
    <dbReference type="eggNOG" id="KOG0925">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_5_11_1"/>
    <dbReference type="OMA" id="MKVYPLY"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17973">
        <property type="entry name" value="DEXHc_DHX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000324">
        <property type="entry name" value="pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000003">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044756">
        <property type="entry name" value="DHX15_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF109">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="95"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="285"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR11150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="749" mass="85532" checksum="6C5D165C1C56DB4B" modified="2013-05-29" version="1">MEEKRVNKRLKQDEKNPYISNLEKDMSQSKSCINSGNFNFLWTSFKKHRTTAEQAEKLENGPINPFNGASFSEKYFNILKKRRQLPVHSQRDEFLKMFHSTKILVFVGETGSGKTTQIPQFVLFDDLPHLNGKQVACTQPRRVAAMSVAKRVADEMDVVLGEQVGYSIRFEDCTSYKTVLKYMTDGMLLREAMNDHLLSRYSCIILDEAHERTLSTDILMGLMKEMSKKRPDLKIIIMSATLDAQKFQHYFFDAPLLAVPGRTHPVEVYYTQEPERDYLEAALRTVLQIHIEEDPGDILLFLTGEEEIEDACRKLAMESEELSRETELAPMKVYPLYGTLPPQQQQKIFEPAPSPRKEGGKPGRKVIVSTNIAETSLTIDGIVYVVDPGFSKQKVYNPRIRVESLLVSPISKASADQRAGRAGRTRPGKCFRLYTEQAYKKELQEQTYPEILRSNLGNTVLELKKLGIDDLVHFDFMDPPAPETMMRALEELNYLACLNDNGDLTALGRMASEFPLDPSLAVMLIGSPEFYCSNEILSLTALLSVPNVFTRPNTAKKRADEMRQVFAHPDGDHLTLLNVYHAYKGVNGDVNWCYEHFLSHRSLQSADNIRAQLKRTMEKNDIDLVSTPFGDKKYYDNIRRALVSGFFMQVAKKSSSDKNYLTVKDNQPVGLHPSTVLNYTPEWVLYNEFVLTSKNYIRTVTSIKPEWLLEIAPIYYDIDEFPSGDMKTALQRVQQKRLRAATIARRTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M7PBY3</accession>
    <name>M7PBY3_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872291.1">
        <property type="nucleotide sequence ID" value="XM_007874100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PBY3"/>
    <dbReference type="GeneID" id="19894112"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00414"/>
    <dbReference type="HOGENOM" id="CLU_990858_0_0_1"/>
    <dbReference type="OrthoDB" id="5330253at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018809">
        <property type="entry name" value="DUF2406"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28186">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28186:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10295">
        <property type="entry name" value="DUF2406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="281" mass="32963" checksum="547AF627CF3CB63A" modified="2013-05-29" version="1">MLFLKKKQLEKSPSLKSKEPLLEIKPLPDKKDFWKQSYRSYEDSMKMLMFESEEEPWQLSQNYYSTYAPIDTRGYIISDPDRSNPTRSRTERPLQTIMGFEEAIYKNKFGDQRTNSITSQSSYIYPIMKFEYSGANAYLPTCTSGSYDESYDKETEYEYSTPNNSSNLSRQYNSNKISSQYPDNSDEFYSSTSSSNHTYGCDNNSEGNYHPSIKYNPSPLERLPEYQSSRYKSLYEEYDQNQYGDFRLAITDNPTDIKTYRSPSNEIQRFRLSKANPKSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCX3</accession>
    <name>M7PCX3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PWI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00179</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872040.1">
        <property type="nucleotide sequence ID" value="XM_007873849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCX3"/>
    <dbReference type="STRING" id="1069680.M7PCX3"/>
    <dbReference type="GeneID" id="19893877"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00179"/>
    <dbReference type="eggNOG" id="KOG2146">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032410_5_2_1"/>
    <dbReference type="OMA" id="QFVKELW"/>
    <dbReference type="OrthoDB" id="163257at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052225">
        <property type="entry name" value="Ser/Arg_repetitive_matrix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148">
        <property type="entry name" value="SERINE/ARGININE REGULATED NUCLEAR MATRIX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148:SF0">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWI" evidence="3">
        <location>
            <begin position="27"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR11745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="360" mass="43047" checksum="1B83715EECAAC4E0" modified="2013-05-29" version="1">MSAGFYKGISSEQDTRFTNAEKKLLRNTKFPDEFSVKVDMDKVNLSVMKPWITQKVIDLLGFEDDVVINYAFQMIESTRFPDPKRIQINLTGFLEKKASVFTKELWALLQSAQQSTGGIPSKFFEEKKAEIHAKKLEEKRIHENTKKQKDDQKHNERVDSSKEKESWRYNSERNGSRYHGKDGNEHDYKNSRSRSRDRKVYNSRRHSHRGNRSSSRDMHVHNDRYYRGNRSHSRNRSHSRNRSHSRNRSSYDRRHRSDRNRSRERDRYSVRRHRHKRDRSYSSDRHTHSQKYRRTSSRHNSPQARYKYRSRSNSSSSSASRSNEDSYGSTSSYYRQRRFSSSETSSSKRSPMHNRELSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7PD45</accession>
    <name>M7PD45_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_00226</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31307"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19521"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132521"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="EC" id="2.4.1.265"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:31308"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872095.1">
        <property type="nucleotide sequence ID" value="XM_007873904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PD45"/>
    <dbReference type="STRING" id="1069680.M7PD45"/>
    <dbReference type="GeneID" id="19893924"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00226"/>
    <dbReference type="eggNOG" id="KOG2576">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022045_1_1_1"/>
    <dbReference type="OMA" id="YHSTDFD"/>
    <dbReference type="OrthoDB" id="1689333at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042283">
        <property type="term" value="F:dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF2">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE GLC1MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR11800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="500" mass="58299" checksum="AD6EDD4C6C2462B1" modified="2013-05-29" version="1">MSCSSFEKYFITSIFIKILLFPAYRSTDFEVHRNWMALTYSLPLSKWYYENTSQWMLDYPPFFPWMEYLFSLFGQWIDPEMLKITNVNYASNKTIYFQRSTVIITDFMLIYSLRKYIQLSSSEKKLTKIIAISIVFSPGFFIVDHIHFQYNGFLYGLLLLSICYAKNSDKILKSSVIFSVLLCFKHLFLYLAPAYLVYVLRVYCLRLDMRGINVKNTIKLIVSNLFVITLAFGPFVYYNQLSQIKSRLFPFSRGLTHAYWAPNIWALYSFIDRVLIALAPHLNIVVKQEAAASLTRGLIGDTFFGILPNITPTTTFIVTFFFQMIYLAKLFIRPTYNVFLGAIVLCGFSSFIFGWHVHEKAILMVIIPFSLLALKDRRYFTAFCPLVVAGYVSLFPLIFTPLESFIKFVYTIAWLLVFLVPSDIMVPASTKRIFLLNRASTFYISMFIPLFIYTTFFHNLIFGSTGKYEYFPLMLISIYCSWGILCSWFGFSLLYLTDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>M7PDK4</accession>
    <name>M7PDK4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_03025</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875076.1">
        <property type="nucleotide sequence ID" value="XM_007876885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PDK4"/>
    <dbReference type="STRING" id="1069680.M7PDK4"/>
    <dbReference type="GeneID" id="19896712"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03025"/>
    <dbReference type="eggNOG" id="KOG0726">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_2_3_1"/>
    <dbReference type="OMA" id="QDDTDPM"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036402">
        <property type="term" value="F:proteasome-activating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031503">
        <property type="term" value="P:protein-containing complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000007">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000039">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="225"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR08544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="447" mass="50419" checksum="02F16FCBBA85AAC2" modified="2013-05-29" version="1">MGNVQSGNNGKPSKQEDQEKKKESKYEPPIMSTRVGRRYNRNKGPDASYKFPMVYPTTRCRLKLLKMERIKDYLLLEQEFVSNQELMKLDSEKKDQKEEEEDDDKLQSLIGSPMGVGTLEEMIDDDHAIVSSATGPEYYVSIMSFVNKDLLEPGCSVLLHHKAVSIVGVLSDDIDPMVSVMKLDKAPTESYADIGGLESQIQEIKETVELPLTHPELYEEIGIRPPKGVILYGEPGTGKTLLAKAVANQTSATFLRIVGSELIQKYLGDGPKFVRELFQTAHDNSPSIVFIDEIDAIGTKRYDSTSSGEREIQRTMLELLNQLDGFDDRGDVKVIMATNRINDLDPALIRPGRMDRKILFETPDQNTKRKIFQIHTSKMNLGDDVLIEEFITAKDEMSGADVKAICTEAGLLALRERRMRVIADDFRKAKEHVLKTKQKNIQGELYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7PEE3</accession>
    <name>M7PEE3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial intermembrane space import and assembly protein 40</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Mitochondrial import inner membrane translocase TIM40</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_02616</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874635.1">
        <property type="nucleotide sequence ID" value="XM_007876444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PEE3"/>
    <dbReference type="STRING" id="1069680.M7PEE3"/>
    <dbReference type="GeneID" id="19896307"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02616"/>
    <dbReference type="eggNOG" id="KOG4149">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1807018_0_0_1"/>
    <dbReference type="OrthoDB" id="7481291at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039289">
        <property type="entry name" value="CHCHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622:SF0">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CHCH" evidence="12">
        <location>
            <begin position="69"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR08829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="143" mass="16484" checksum="A03331F38B325AA6" modified="2013-05-29" version="1">MPLIAYSISPFIKADTDRGTLKNTNNYNEEISTFSNSENNGEKYAFNPETGEINWEDYQTNSIVAHGPCGKEFKDAFSCFVYSKEEPKGMECIKKFQAMQECFKKYPEIYNNGNLSFHYCFFLNAIKEISNEDDIEITESNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7PEH8</accession>
    <name>M7PEH8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="4">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_02654</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874675.1">
        <property type="nucleotide sequence ID" value="XM_007876484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PEH8"/>
    <dbReference type="STRING" id="1069680.M7PEH8"/>
    <dbReference type="GeneID" id="19896345"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02654"/>
    <dbReference type="eggNOG" id="KOG2457">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_0_0_1"/>
    <dbReference type="OMA" id="QQTRMET"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035485">
        <property type="term" value="F:adenine/guanine mispair binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032357">
        <property type="term" value="F:oxidized purine DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029119">
        <property type="entry name" value="MutY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="ADENINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944:SF1">
        <property type="entry name" value="ADENINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14815">
        <property type="entry name" value="NUDIX_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="14">
        <location>
            <begin position="68"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR08869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="453" mass="52553" checksum="B8D0D701CE7A1062" modified="2013-05-29" version="1">MIGAHKASCHAFEDLKHIRKSLLAWYRSNARVLPWRKPYVNPPTISMSNKERTLSLQRAYEVLVSEMMLQQTQVATVVPYFERWMKKFPTWDVLETADLEEVQNIWAGLGYYARARRMKEAAMYFMELERRSETIPIDVATWIKNVPGCGEYTAGAVLSVAWNIRCPVVDGNIIRVLTRLRAVGVECHKGIGKKWVWDSADQLVDNEYPGDFNQALMELGATVCTPVNPSCDICPLNKDCLALKEAKNVLKQNIIDNNYEEHDCDLCPIEELGQFTSIKTYISSKYPRKVVKKKPKLKKNIVFVILREKNMLKEYYLEKRPPKGLLAGLWDFRTLPVDIEQKYEIQDAENYAKTIISGEIIGVWKKGDTLHQFTHIRQISYVYLVIIDINAEIYGKGSWMPEEIMKNQSIPELTWKNFRQATNNEKKILNKTKNTNKKLKVDNNKWKQTTLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7PET2</accession>
    <name>M7PET2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02749</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMD3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874780.1">
        <property type="nucleotide sequence ID" value="XM_007876589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PET2"/>
    <dbReference type="STRING" id="1069680.M7PET2"/>
    <dbReference type="GeneID" id="19896440"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02749"/>
    <dbReference type="eggNOG" id="KOG2613">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027444_2_0_1"/>
    <dbReference type="OMA" id="VILVRKH"/>
    <dbReference type="OrthoDB" id="203821at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="8">
        <location>
            <begin position="36"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="10">
        <location>
            <begin position="267"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="9">
        <location>
            <begin position="331"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR08974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="525" mass="60812" checksum="C7B8F6DA73C64E35" modified="2013-05-29" version="1">MSYVQENIVHKMTSELMQGTCLSSFAFENQAHEIFCCQCGVPISPNLSTMCIDCIKTGIDITEGISKESILYSCRECGKFLHLQNQWLSVQMESKEFLSLCLKKIRGLNKVRLIDAFFIWTESHSRRVRIKVTIQKEVMVSTILQQTFEIKYTVMYQQCPDCFRMYSAHTWKALVQVRQKVNHKRTFLYLEQLILKHSAHKDASSIKEIKDGLDFYYLNRNHAIKLVEFLSTVVPVKIKKSEELISTDVKSNISSYKFTYSVEIVPICKDDLICLPKELAKSLGNLEQLVLCYKVGNSIHVIDPRNLQIGNIIPAIYWKFPFFSLCDVKDLVEFVVLDVELVGPVSGKFVLAEVLVIRSSDLGLNNSYFVHSHLGSILKAGDTVLGYYLENLNFNNLTFEAYQETCAYVPEVILVKKSYQSKRKKSRTRNWKLKSFFGKERSEINEKKHDHTCSEEDYERFLQDLEEDIELRQNVNLYKTKTNCKKISMNVDIEDETESSDEFPEIDVNELIDEIEEMNISSEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>M7PFA7</accession>
    <name>M7PFA7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="8">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_02487</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="8"/>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874496.1">
        <property type="nucleotide sequence ID" value="XM_007876305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PFA7"/>
    <dbReference type="STRING" id="1069680.M7PFA7"/>
    <dbReference type="GeneID" id="19896180"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02487"/>
    <dbReference type="eggNOG" id="KOG0940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002173_0_0_1"/>
    <dbReference type="OMA" id="WKRPTLD"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120113">
        <property type="term" value="P:cytoplasm to vacuole targeting by the NVT pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08382">
        <property type="entry name" value="C2_Smurf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000011">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000156">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000005">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024928">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001569">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 8 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="13">
        <location>
            <begin position="212"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="13">
        <location>
            <begin position="300"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="13">
        <location>
            <begin position="359"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="14">
        <location>
            <begin position="448"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="241"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="9 10">
        <location>
            <position position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001569-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR09144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="781" mass="89309" checksum="769F978AE4391E78" modified="2013-05-29" version="1">MASNSPVQKIKLTVIAVDGLYKRDLIRTPDPFAVITVDGEQTQTTSVIKKTLNPYWNESFEISVKESSILAVQIFDQKKFKKKDQGFLGVVNLRISDVIDLSLGGDEMLIRDLKKSNDNMMVHGKLIISLSTFVSVPGRNQSSHNGAAQINGLASGSATVSMSMNPSPSRIGIVSNSAAENTETGHSASQSSRHMASYQGSGNYSSFEDQYGRLPSGWERRTDNLGRTYYVDHNTRTTTWTRPFTGRIDSDGLSQARPSARESVSSHMATSSSAHHGSSSTNEQNRVPLVSGITTNPGTGDLPSGWEQRYTPEGRCYFVDHNTRTTTWVDPRRQQYIRMYSGANMGNTTIQQQPISQLGPLPSGWEMRLTSSARVYFVDHNTKITTWDDPRLPSSLDQNVPQYKRDFRRKLIYFRSQPALRPLSGQCQIKIRRNHIFEDSYAEIMRQTPSDLKKRFMVKFDGEDGLDYGGLSREFFFLLSHEMFNPFYCLFEYSSVDNYTLQINPHSGINPEHLNYFKFIGRVLGLAIFHRRFLDAFFIVSFYKMILKKKVTLADMESVDAEFFRSLTWILENDIANVLELTFSTEDDRFGEVMTIDLKPNGRNIEVTNDNKKEYVELVAYWRVFKRVEEQFNAFQDGFNELIPQELISVFDERELELLIGGITEMDMDDWKKHTDYRGYTESDEIIQWFWKCVRSWDSERKSRLLQFITGTSRVPVNGFKDLQGSDGPRRFTIEKAGEITQLPKSHTCFNRVDLPQYPTYEMLVQKLTLAVEETVGFGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M7PG09</accession>
    <name>M7PG09_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_02339</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874343.1">
        <property type="nucleotide sequence ID" value="XM_007876152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PG09"/>
    <dbReference type="STRING" id="1069680.M7PG09"/>
    <dbReference type="GeneID" id="19896032"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02339"/>
    <dbReference type="eggNOG" id="KOG0240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_3_1_1"/>
    <dbReference type="OMA" id="DSKSREC"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23649">
        <property type="entry name" value="Khc_CBD_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01369">
        <property type="entry name" value="KISc_KHC_KIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000031">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059182">
        <property type="entry name" value="Khc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 9 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="12">
        <location>
            <begin position="5"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="442"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="595"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="86"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR09394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="864" mass="99439" checksum="28048172D1C11CFB" modified="2013-05-29" version="1">MASNHVQVVCRFRPLNKFERSLGNGSLIVCCDTSTVEINTKELIGRFVFDRVFDGSARQSEVFEGTIRSTVDDVLKGYNGTIFAYGHTGSGKTYTMMGPNIDSELRGVIPRIVEYIFESIMKSQSFIEYMVKVSYMEIYMERIRDLLCPQQDHLPIHEEKNRGVYVKGLKEVYVSSLDEVYQIIKKGNQVRVAAATNINPESSRSHAIFCITIMQKNLETENTKSGQLFLVDLAGSEKVAKTGASGQTLEEAKKINKSLSTLGLVINSLTDGKSTHIPYRDSKLTRILQESLGGNSRTTLIINCSPSAFDEQETLSTIRFGIRAKNIRNKARINQELSLNELKFQLKKARTQLLASSEYIVALENELDIWRSGERVHEEKWTPKMIIDIIPKSKIVLDNEKDNITESIMLEKKSVPFIQNVIMEKDERDSFLKREIELQDMVIEKEMLLNNQEKVLKDAKEEILYLKEQNNETVKINEELTTKVNDLQLELERITFENKEAYITLDSLKYTNESLVSELNNMRQSLFEAKAAMESIVDHESLKKKTKQIMKESDFSVNKISSSKQFLDDLNNFSEITTNSTKVLKDRLTEMQSVISSLEIALNDRMNEADNLKKNNSKLEYRLKYVEDEYQFLIDKLLFKENEQYIKVHEILFNQSCNLQVCNGLFQVNNSEEVPSKLSKEASSKSFNERFSIKNEFDVSDNDNLVNSSALKTEEFSLVKKSLMKEFQERRDKVVDLEISLNEIRQQYTNILRNNNVKNQRKKMLCLEKNLEQLIVIQKQLVEQNTSLKRDISIAERKLVVRNERISSLETLLCDAQGKLISQNRAFEKQIQILKERLERIRAKEYSSELSFGKIAKPLRGGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7PG65</accession>
    <name>M7PG65_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_02398</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>glycerol(in) = glycerol(out)</text>
            <dbReference type="Rhea" id="RHEA:29675"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874402.1">
        <property type="nucleotide sequence ID" value="XM_007876211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PG65"/>
    <dbReference type="STRING" id="1069680.M7PG65"/>
    <dbReference type="GeneID" id="19896091"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02398"/>
    <dbReference type="eggNOG" id="KOG0224">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020019_9_0_1"/>
    <dbReference type="OMA" id="CALGRMP"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000027">
        <property type="entry name" value="MIP aquaporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF9">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02019">
        <property type="entry name" value="AQUAPORIN7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="207"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR09454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="28453" checksum="652D9854AA1A728F" modified="2013-05-29" version="1">MILFGDGVVAQVVLSGSTKGNYQSINWGWGIGVMFGVYISGGISGGHLNPCVTLANCVFRGFPFWKFPIYALSQTAGCFFGALIVYLNYYSAFDAYEGAGKRTVVGPTATAFVFSTYPASFLSTGRQFLSEVVGSAALMVCIFAICDQYNTPANDKGPLIILFLIFGIGACLGWQTGYAINMARDLGTRLLSYVIGYGNEVWSAGHYYFWVPIIAPFIGCLLGGFLYDLFIYIGVESPLNSPYFGIKRLSRMMFHSSLPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M7PGI3</accession>
    <name>M7PGI3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tag1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874136.1">
        <property type="nucleotide sequence ID" value="XM_007875945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PGI3"/>
    <dbReference type="GeneID" id="19895848"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02155"/>
    <dbReference type="HOGENOM" id="CLU_501639_0_0_1"/>
    <dbReference type="OrthoDB" id="5596576at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046368">
        <property type="entry name" value="Tag1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055011">
        <property type="entry name" value="Tag1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895:SF3">
        <property type="entry name" value="PRE-RRNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26174">
        <property type="entry name" value="LEA-2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22786">
        <property type="entry name" value="Tag1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Tag1 C-terminal" evidence="2">
        <location>
            <begin position="434"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="543" mass="63114" checksum="DAF37702D0D09EB0" modified="2013-05-29" version="1">MSFLKNINNDGENRVGEETPLLCNKRKFGRLKSVFERASLKIILSILKKMVIFYLIFFVIVFLISLILYIGKKNISEAYKVSFNEIDVKNVTKEGLNIQVSGCVDVDYSNIKPMIIKNLWKGFTGIVGNLRVYGFNLNIYLPDYLEKKIATVILSKIQIDIRDQHYTNFNETTFLKFDDSMVLIELFKRFCEKIFYDIKISREASFRLHFLYFLIFPVSIGRMTTIYNFPETSLDKVFDMNSLVIKDSSSDFLNAEIQLSTKIDFSISTYLPYLTWNVLVSSCDETKHVKIAKIKSYFFYIKSSKRLNITLLSRITSPNNELIDICNDTGISPLNRIVSGYFSKKHLYIYMIGDISETSMESYVPSWLLRTLTTTEIPVPLHGFPNTKFIKSIKIDKFVMKNNKEDFIYNSFWFPPSFYGIVIVKIGFPGAFDFYINITHIRLNIELSSDGIPFLKISQNDWISSTSLRPMPSILLLKTKIYDKYFKILNITVFKKILRENILHRTNNIVFYIKGNVSLKLDSRLGSFYFQKVPISGDVLVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M7PGL7</accession>
    <name>M7PGL7_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874171.1">
        <property type="nucleotide sequence ID" value="XM_007875980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PGL7"/>
    <dbReference type="STRING" id="1069680.M7PGL7"/>
    <dbReference type="GeneID" id="19895880"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02187"/>
    <dbReference type="HOGENOM" id="CLU_467010_0_0_1"/>
    <dbReference type="OrthoDB" id="5378105at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="553"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="584" mass="68289" checksum="76FA502DF62D8963" modified="2013-05-29" version="1">MFYWDTKKYNNKDNTEENHSYESNKSLSHSKLLSQTPKTPSATNWVLQAFRDHFFYVIYSGKKTYLKENNNTLCKDQFNSSIKTDFITKTRPIDTLKTIDNKKSDIEKIEHTSVDKKECKENIQISDIKTPKRQNSILRPPGTNGTRKTVSFYDVYEHDNGTYDSEENKTYFFRKFPGKFPSPYLSKSKNFEADKTCANTIFSSDFKAIASNSKKSPTNILYQQINSITQNNQKLRLLISEISEETSIFHDHLENNTSKFNITDNIKDHLSSGKYWKTKFETLNILKKNLENENQFWKSKCFHLEKQLQKLSKIDLMHSKKNDVGNDLFIKESRRESLSGNSFPENILENIKNDLIDDIGDIKIQTIEKPNIHLVTQNSDKNIQIENSEKEFCNLKTSLNNACYLFKNNDNKHPKVNINMNHREINKNKKSMKELNTKNDFSNYQKKCKDPDTIIFNCDTSDKKIKNKKTINQNFTELSTKKGDSRNDNSDTFKKDILDKNSNFSKSITNNTYHFKNSQQLQEIINEIPENLQYPTKPFSNVLDPISRKAAAAKRLEERRKNKDKVDKIKQNNLEKENINHFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7PGN5</accession>
    <name>M7PGN5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">A1 cistron-splicing factor AAR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02203</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874186.1">
        <property type="nucleotide sequence ID" value="XM_007875995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PGN5"/>
    <dbReference type="STRING" id="1069680.M7PGN5"/>
    <dbReference type="GeneID" id="19895896"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02203"/>
    <dbReference type="eggNOG" id="KOG3937">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024943_2_0_1"/>
    <dbReference type="OMA" id="NWIDILM"/>
    <dbReference type="OrthoDB" id="201752at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13778">
        <property type="entry name" value="Aar2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13777">
        <property type="entry name" value="Aar2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.550">
        <property type="entry name" value="Aar2, C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007946">
        <property type="entry name" value="AAR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033648">
        <property type="entry name" value="AAR2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038514">
        <property type="entry name" value="AAR2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033647">
        <property type="entry name" value="Aar2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038516">
        <property type="entry name" value="AAR2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689">
        <property type="entry name" value="A1 CISTRON SPLICING FACTOR AAR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689:SF4">
        <property type="entry name" value="PROTEIN AAR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05282">
        <property type="entry name" value="AAR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20981">
        <property type="entry name" value="AAR2_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAR2 N-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="AAR2 C-terminal" evidence="2">
        <location>
            <begin position="189"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR09619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="44645" checksum="44FD77B356E5BBE7" modified="2013-05-29" version="1">MTSIFVLDVPPGSTFGIDGHSWITGHRFCGVRGLSNGLHWAYYNISGAKKDVGNNIENTQLKGLESFSQGFFFYVDCSVLIFQYNHYKEMILETDVTASELDIIEPWLIPFPDENGILKGFDEDHIDKTRDGRYIDDGHCFYHLIAWVTRNMLNCLFPSGWHVTSITSSNLDEVLSGLPAIETEPEIVFLAINSRRTWRPGAFGREVTEGFLDKSWELERILQHVCLGDSGRFLGEFQLCFIIFLFVSNGSCLEQWMRMLTLVSSCCRAISVFPDFYVNWIDILMIQLLYCPEEIYQDIFQERNFLKISLKNLRRNLFDAQVGSASISAVKDAFTRLSSAVKQKFCLNIETQPEVSIRSSLVYGIENDELIDTSESNSMADDSDDDPVIVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7PHA4</accession>
    <name>M7PHA4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Actin-related protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02005</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873985.1">
        <property type="nucleotide sequence ID" value="XM_007875794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PHA4"/>
    <dbReference type="STRING" id="1069680.M7PHA4"/>
    <dbReference type="GeneID" id="19895699"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02005"/>
    <dbReference type="eggNOG" id="KOG0681">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008246_1_0_1"/>
    <dbReference type="OMA" id="YPFTEHV"/>
    <dbReference type="OrthoDB" id="7340501at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10211">
        <property type="entry name" value="ASKHA_NBD_Arp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000122">
        <property type="entry name" value="ARP5 actin-related protein 5 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="714" mass="82842" checksum="F9E53862D6F9A54F" modified="2013-05-29" version="1">MVGVAPMIYDVRDIVFEGECISSSSGPGNPLILIDNGSWQCRAGYATELSPRIVFDSFVSKYRDRRLMRTYTLVGNDTLVEPMARHIAKSPFDFNIVANWDVMELLLDYVFLKLGVKGNERVEHPLVMTEPVCNPNYSRGVMSELLFECYCVPSVCYGIDSLFSFYYNGGTDGVIVSVGNNTTHVIPVLKVSGHLGASKRISWGGVQSTEYLLKLFQLKYPNFPQKMTFTQAQCLLHDHTYVSLSYKDEIKTFLDPEVLAVQDRIIQFPCTETVSNLKTEEEIARLAEKRKEAGRRLQQQAQKTRLEKLMQKEKDMEYYVKLQEAIKFKDKRYVMEKLESEGFADETELLTTIKRLDTAIRRAKNKDSCQDTEIPSFPLLDIPDSELDEAGLKQKKHQRLMKSNYEARMRSKAEKQVKKARNEEMERLDEEKRLNDLEKWLEEKRNARNCLLEKIKEKKKLKADLNDRKSMASQMRMKSIANLASEQYSRRKRRRATEIEDTFGANDEDWAIYRNIVNTSESDEDNNNLQHLESQLMLYDPAFAKDDLLDFNEDPTKSWIHKFYRGVYPPFDPNDVQQLHQLHLNVERIRVPEIYFEPNIVGLDQASIIEVISDILSRFDLNDSQKMANDIFCTGGASLLKNFSLRVEKDFRALWPADKSICVRQAKDPLIDPWRGMQQWSHTDQYKNSYITKQEYLEMGSEYIKEHGMGNVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7PHH2</accession>
    <name>M7PHH2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LisH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01664</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873626.1">
        <property type="nucleotide sequence ID" value="XM_007875435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PHH2"/>
    <dbReference type="STRING" id="1069680.M7PHH2"/>
    <dbReference type="GeneID" id="19895358"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01664"/>
    <dbReference type="eggNOG" id="ENOG502R28W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_336819_0_0_1"/>
    <dbReference type="OMA" id="VEWFNIF"/>
    <dbReference type="OrthoDB" id="5600002at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45093:SF2">
        <property type="entry name" value="LISH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45093">
        <property type="entry name" value="TRANSCRIPTION ACTIVATOR MSS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="254"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="502"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="642"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="503"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="645"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="696"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="747"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="761"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="788"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR09904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="846" mass="93566" checksum="91114FEBD0A2CCF4" modified="2013-05-29" version="1">MSEKWGEERGAQILLNSYIYDYMLKNAWSTAARAFMEVAEVPLSSENRSGNKEERIQLDMMDGLRGNDKEGCLGGGDSKGDNFALSSVKQEPAHSGESETGGAYSGLLQPAVIPVDTPGGFLLEWWTVFWDIFNAKSGKGGSDAATAYFAHAQKMKHEQQRAIASMGQPHIVMINPQSNSTTFNPAFMRTFDIPNGMVNISGQSDTATQAVDTQIIGTIPLNEKTRQILMRQAMNNNIRRFSPSAAQIQQLKNQQFLQNQQQSSTSQAQRNQRDLETDVNGQTQSSRSPALSNQVLSPSKRQKLSPDGSYTSVQGTIQARPQMIQNNLVAASTTLQTQQAKQMLLNSGINPVGLTQQQFTAFQSQTPSIQQRQLQEYTQGFANQQQRVINIAKGQVSNQCVPSSIITGDGNEIGPNDFYGNILSSQQNCPTNPNNHVLEDYQMQLMFLEQQNKKRLMMTHQDQERLQSQDSSAFQILSPQGVRNALSPKNNHNDAKRGISKVAHQNSPNSPTDVSLSQQNNTSRNTSPSVAGYNGQIQSDTHSQIMFFNQAKTMGDMQSDGMMISHNGHIIRSQMTDQPIYTNNPQMQIAMINGRPEHLINSRVVRTNQPSAIWQQQQIMQHLVNQNQNRNIQMQNINHTQGHLNQHSPQNQISQQSQQQSQQSSQSHQQQSQQQPQHPQQQQIQTSQNILQSTSANQTSQGHIQSSPIVQNSVSPTPQINKLNLIREKKGKDARKSKKTLSGAPVTPISESSSSTPITSHNGGNFLQTNSSASQENSLLQTPGSIVPSSDQAQAQADPPSSSSFANIDNGDPSSFLNDFNAGNDLDLGIMNDFDFDSFLEDIRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7PHI1</accession>
    <name>M7PHI1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_01674</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873636.1">
        <property type="nucleotide sequence ID" value="XM_007875445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PHI1"/>
    <dbReference type="STRING" id="1069680.M7PHI1"/>
    <dbReference type="GeneID" id="19895368"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01674"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_2_0_1"/>
    <dbReference type="OMA" id="FGECGHI"/>
    <dbReference type="OrthoDB" id="423559at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF16">
        <property type="entry name" value="ATP-DEPENDENT HELICASE ULS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="280"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="621"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="778"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR09914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="949" mass="110528" checksum="73C6DC28F372178B" modified="2013-05-29" version="1">MIQNESKPNKFNEGAPIESYEIFDDEYENSAQSVDSDDSLIIFTKEAPPTSLLSRKTLENGQFVEEINQEKKQSQKKSKENIKYQLFSKDEREKPLRVSDDICILTPYSIEEIPDSEDDNSEIFLENEEIEFSKAYVDNNTPIRSNLKYFVNSEDNAIMKDQTTTKNESLIQYPDRPLPWKKPEALGTLNNPIDLSKDLSGHFPPPMPLPYSKYEYQNSIFQETNISSSYPRILDTNKEIMALFDNIYSMNESKIREGTPKRLLPTLMEHQKIGLSWMKEKEEGTNKGGILADDMGLGKTIQALALIVSEDENKMGTTLICTPVSLLQQWAREIRTKTKPPLKLYIHHGNSKRIIQPSELNKYEIVLTTYGTVVRDHKTLIKLQKDPDHSTYMLYKPAFTLLEHHWHRIILDEAQVIKNRHTLSAQSCYKLQATYRWCLSGTPMQNSIDELYSLICFLRIKPYDDWSTFSNHFSKHFNRYSCSNYIMKSMKRLQVLLKATLLRRTKTSTINGKPLLTLLPINIELVYTIFSDEEHAFYKKLEAQTQLQVSHYVNENVLGSHYTNLLVLLLRLRQACDHPWLVKIKESTEISENDLENQEKLAREIFAQQVQNIQRLKDFECHVCYEVILSPNFIVPCGHYYCRDCIIRVIDQSQKTSIMNGNVTLDARCPECRCIFNMKKVIDFSVFKKVYNWNYEPNFIKEDKVSDEETDDEDLTVIKDKGKQRAVIDNKFAVNDLDVKLAWKRIFNHKFIKQTKNKFHQHLEKNNDQFKSSAKIDKCIEILDKIKHNNSLEKTIVFSQFVEFLDLLEISLLLKGYKILRYDGRMSAIHRDQSLFMFDQDPTHTVMLISLKAGNSGLNLVSASQCILLDPFWNPFVEEQAINRIHRIGQTKPVQIYKLVIKGTVEQRVLDLQKRKRDLIENALEENACMQISRLNKQELSFLFGLQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M7PHJ1</accession>
    <name>M7PHJ1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873646.1">
        <property type="nucleotide sequence ID" value="XM_007875455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PHJ1"/>
    <dbReference type="STRING" id="1069680.M7PHJ1"/>
    <dbReference type="GeneID" id="19895377"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01683"/>
    <dbReference type="HOGENOM" id="CLU_737929_0_0_1"/>
    <dbReference type="OrthoDB" id="4088568at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR09924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="375" mass="43676" checksum="6CD2474BCE1D085B" modified="2013-05-29" version="1">MNADSIKSFPFIEKPHLILFIKELISKNSFLKKICTELYDILSITQNETIYLQQILSRNNNYGSLFNNSYNLYNLKNMLHFNVNNYLFLEKELNEISSNQIFNENINANILQKSDKENREGYSSKSINEIKIKSKYDFIDSLFIPIKFKKLYLNNSKITRSFSAPDILSLFSSSSKFQNTQNNLHEKTRYLSLTDMFNSPKLISMNNKRRNSCLNLSKELRHSQYNKFNSDLSIYLDTPNTSFFKHILYKKPLHGVKSEDLRDSFLLRKPWTTPRNFSPPTQFISPVISTFSTSPSESSVLLNNDTKTMLSNSLLKSTIINRFFLSGTSKKEKADTKSSGKDIHDNRNKSMWDSFFNKWPKLIHTKHSLTSTSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJ30</accession>
    <name>M7PJ30_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01173</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873088.1">
        <property type="nucleotide sequence ID" value="XM_007874897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJ30"/>
    <dbReference type="STRING" id="1069680.M7PJ30"/>
    <dbReference type="GeneID" id="19894870"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01173"/>
    <dbReference type="eggNOG" id="KOG3996">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048602_0_1_1"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF3">
        <property type="entry name" value="HOLOCYTOCHROME-C SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00821">
        <property type="entry name" value="CYTO_HEME_LYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR10459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="250" mass="29131" checksum="3A77534275CB5585" modified="2013-05-29" version="1">MGFFWAGYDAKVESTNCSNNISKKSNENCPIFKLESKNVCPSRKDEEINPLNKMPKELPQTMGYNQKNILSTRRTMSSIPRNDINENWEYPSPQQMYHAILRKGKKDVSEEAVEPMVEIHNFLNESAWNEIKKWEERRGCYNPKLSHFKGRASDYTPKSLLFYYIGKIYPSKFGSSLPFDRHDWYVSRNGKIVRYVIDYYDAPPEPSGEVAFYLDVRPAIDTPVAAYDRISVWTSKIWARLFENSGNLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJG3</accession>
    <name>M7PJG3_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01307</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the MSS1-MTO1 complex that catalyzes the 5-carboxymethylaminomethyluridine (cmnm(5)U) modification at the 34th wobble position (U34) of mitochondrial tRNAs.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873233.1">
        <property type="nucleotide sequence ID" value="XM_007875042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJG3"/>
    <dbReference type="STRING" id="1069680.M7PJG3"/>
    <dbReference type="GeneID" id="19895004"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01307"/>
    <dbReference type="eggNOG" id="KOG2311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007831_2_2_1"/>
    <dbReference type="OMA" id="CNPAMGG"/>
    <dbReference type="OrthoDB" id="3329at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070899">
        <property type="term" value="P:mitochondrial tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000082">
        <property type="entry name" value="protein MTO1 homolog, mitochondrial isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.570:FF:000001">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000002">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="entry name" value="GidA associated domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00129">
        <property type="entry name" value="MnmG_GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049312">
        <property type="entry name" value="GIDA_C_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047001">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00136">
        <property type="entry name" value="mnmG_gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="GLUCOSE INHIBITED DIVISION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PROTEIN MTO1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21680">
        <property type="entry name" value="GIDA_C_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="SAM_GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01228">
        <property type="entry name" value="GIDA_assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain" evidence="6">
        <location>
            <begin position="582"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="671" mass="76224" checksum="3A2A96EF0823217B" modified="2013-05-29" version="1">MKSLFSFNIIINRRNFILFNRIFFEKRLFTSFKDIEKFQIVVIGGGHAGCEAAAVASRSGLKTVLVSQDINKIGETSCNPAFGGIGKGTLVREIDSLDGLCGVISDRAGIQFKILNRAKGPAVWGPRVQIDRLLYKKYMLETLSSYKNLTLLKGIAIDILTEPLSEYEDIYKTRKFKVSGVVLESGEKILAEHIIITTGTFLNGEVHIGSKTFPAGRIGESATFGISTFLKKKGFKLGRLKTGTPPRLDIRTINYRYLHPQLGDEPPVPFSYLHSEDTIKNKILCYSTYTTEETHKIVRDNLKESIHVQKNIKGPRYCPSIETKVIRFPSRNHHIWLEPEGIDSNVVYPNGISVTLPEEIQLKMLRSIPGLENVTMLRPGYGVEYDYVDPRELYPTLETKRIKGLWLAGQINGTTGYEEASSQGLLAGINASLSKKGQSQATISRGLAYIGVLIDDLVTKGVEEPYRMFTSRCEYRLSIRADNADLRLTEFGHKLGIISKERWDQFNKDQKLFMDAKKALESLVLSPQEWKSHNISVNMDGIRRSAMQLLAYPNITADTFLNIIPMLHDIPTKIRLRLNIESIYSEFITRQEFENRYLLQKNEEFIFPPDIDYNKLNNLSIEEKELLNSIRPQSLAQAKRIQGITPSAQLVLLRYIMQNKKRHKTLDNIYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7PK57</accession>
    <name>M7PK57_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">IPT/TIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872884.1">
        <property type="nucleotide sequence ID" value="XM_007874693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PK57"/>
    <dbReference type="STRING" id="1069680.M7PK57"/>
    <dbReference type="GeneID" id="19894668"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00970"/>
    <dbReference type="eggNOG" id="KOG3836">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_278114_0_0_1"/>
    <dbReference type="OrthoDB" id="71307at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00102">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057962">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25603">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1098"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="3">
        <location>
            <begin position="531"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1138" mass="132065" checksum="2994EED7DD6D322B" modified="2013-05-29" version="1">MFPQEVSLAFSSSNDIDLSFESYRDLYGNYVHPSLKERNEKDSSSEERLDYDPSDDDAVIDREGFSPSFNNNYSSLMDINGLGYKKDFCFCKTLSVYDISMQNTDFDNVPLDVYSNFNSYEVNGMKKDYNEIEEVPSLIPDLEEINIPAPYILNIFGIPEKSRVETQVKLGIKLTPSSSVEEHFNNDFFWLKLPSWSITKEKLKLPNLKNHPKYIDPEKILTLEPSVVCASDITKNVLICSGCIIRERKRAIRKKKTKFQKEFGQNQDSLSPIKDEEKKIILFNYPEIFRFKDNYINIPTRITCYCRHHKENIGFRILINIKDNKGQLIASTLSKPFMITDDHKTISKIKKINGLHLTPNSLPIPVNDNNSNQKKNILFNEELKLAVNPENFSCSTLDNMTNKNIIQPAYNSMIYLQDDISNKNKSFLVDDKFMGSESYESLLLPANVQQDELETIPQTSSLVLSQVSSPETVSKMPFSIDSNLFDLSLETQWSNKELHMNIDQTDFSNQVNLPVPNNYTPIELSENPIEIPIIDRLIPSEGPMHGGIEVTILGSGFYSGLTCIFGHNPVTSIHYWSPTVIVCTLPPSPIPGPVLVDFKEHNLAQSDIENAKYFLYKDDNDRTLMELALQVVGIKMTGKLENALTIAMKICGLMPSDCNESNLKQQQSNLNSYKPTLMNYLHSSSTFNIYKAYYCFETMFFQHDNLLNIKANPNTFYLLYQDRPNQTLLNHIYVQELQRHIIELFSKNYYLRSIKQCRYNHVDYLNMKKMNFIVKMLENTEENRFIYRSLYRKVFKLTYPNSYIEISNFLRLNREHMDYIIVSLVFSWLNQNNFILKKRSNALLRTATEGFDDNDFFDIFFSSKKNNRPFKNRLNKTKKYSEVENLHHSDSLVGSYNTDNESKEISSHFSQSQHIFDIQENQTTESNIKDEKNDDGIFTIQGFSEFLTMTSAKAKLASLSIPSILRTSSLPQFSEFGQFHPISAFNSFIQQYPFISKKANNSKSSSIMENDIQYNWWQHLIFGPPPPYSELSTNENVFETPSDASEDFVFSQEKSQRYSFKWQPKVLTRSRTAELILEQQQFIREHAKIIQKLEKDKMLYLFWLPILIILSSYIILNWTQKDVSIRIYDLRRAITFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M7PLL5</accession>
    <name>M7PLL5_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872241.1">
        <property type="nucleotide sequence ID" value="XM_007874050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PLL5"/>
    <dbReference type="GeneID" id="19894066"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00368"/>
    <dbReference type="eggNOG" id="ENOG502S8X6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_839694_0_0_1"/>
    <dbReference type="OrthoDB" id="5397183at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="331" mass="39168" checksum="7D43E9A74B9FC303" modified="2013-05-29" version="1">MTDLNIYIPVTNKNFEEKVNLKKKKESDTLLKIPETWNFNRDLSNVSSIFKEKIKWDSLSLKKIEFHWKNYPYYLKYDAYKSKQEKNQEKYQKIEYIKSFPEYISDNSKTNITILNEDNQIIKNNELTDNNLTKKPNFHSKALDNSQKITYKNHSTISIQKNNEKSLLFKTNCNISTHEFVSKKESFNYPISPIARNPFPLTILGKSVISGLSSNDTLLRTCFRVGEALKVSNLQKNSMIIYLIEFFGIIKEFNKEKSLFTYVIADLFHPLRGPYIYASYHDYHITITFQNNDIVRILGVFKKNRTRNEINVIKMYPCTWEKIQHIKETMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M7PLM8</accession>
    <name>M7PLM8_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872256.1">
        <property type="nucleotide sequence ID" value="XM_007874065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PLM8"/>
    <dbReference type="GeneID" id="19894080"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00382"/>
    <dbReference type="HOGENOM" id="CLU_1518505_0_0_1"/>
    <dbReference type="OrthoDB" id="5424477at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="177" mass="20725" checksum="0F0162C73A2AFE1B" modified="2013-05-29" version="1">MKWIEYSFICLIIFSNCIFSMDLERHIFYRGSEFRPRNHLIYKSLKKDFYNEISEEYLLESSSSEWNSLKGCQDMIVCKVHVEGTEVVVLRVIGKESLDDTHIENTSENSGEKEFTEFPTMEDFNSDETQEGNLIDHFIDNCEECEECQECGECEGYEGCDDNEFYIEESNSLSNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7PLP0</accession>
    <name>M7PLP0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SWIRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00396</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872270.1">
        <property type="nucleotide sequence ID" value="XM_007874079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PLP0"/>
    <dbReference type="STRING" id="1069680.M7PLP0"/>
    <dbReference type="GeneID" id="19894094"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00396"/>
    <dbReference type="eggNOG" id="KOG0029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004498_1_2_1"/>
    <dbReference type="OMA" id="WCAENPF"/>
    <dbReference type="OrthoDB" id="9982100at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF386">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWIRM" evidence="6">
        <location>
            <begin position="245"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="983"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="983"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1113"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1120"/>
            <end position="1134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1152" mass="130646" checksum="C4093B90DBA9802F" modified="2013-05-29" version="1">MEDESNIRANAFQHIQHPSHQKGFYQRTNEQSLTQESVHSQLGNSLAEQEALWTLLQQQQSQSLQNHQGYYSTPNLGWSNQGYSQFRAYPQQIAPSSQGYSQYAQYPHQKQQPYAPYAPQHPYYSQSLDYGYTHHHTLQHSSPHLQHYLGGRMNAHAHSLSSIRMNIPKNIINPSPGFQSTIPTVASSSNTMDIINVPEEKNEGPNEAVSEVRYIISESFDRTVVPSLKSSIPPGINHQEYTRDCVNAAIASRLSPYHLSESEHLLLRTHLTHLQITSYLNIRNAILRLWVRNPLLYVDQYEALGIAHEERHFNLVKVCWELLVREGYINFGCINIPKSLVTPSVGIKTIVVIGAGISGLASARQLESLFQIFSNRFDYQIPKVVLLEARGRLGGRVYSHKLTSLPTEEDFPKDKCSTVDLGAQIITGFAKGNPLSTLLVKQLGLPMHFLSVHNITLYDSNGEMVLPDTDSRAELLFNYILEIASKFKSKETSINTKRVLEGDKNMVDAGVEPKSEGGRVIAKIEDNEATIPMMEDYSEINSKDLNKLDQSSSEDNKKKSDYDLVSVLRKIGFQIKENVSIHVNFDDIVSEQNPTLGYAMSKILSQYQSLIDLTDLDMRLLNWHYANLEYANGTNLSNLSLYHWDQDDGNEFKGAHAMVKGGYSTLAYALAYMPTPLEIHYKTVVSGISYNDKKAVVYCEDGTVIDADKVIITVPLGVLKESSIQFSPPLPVWKMQSIERLSFGLLNKIILVYENSFWDVNIDVFGSLSEPDDQGIYDKNRGRFYIFWNCIKTSGQPVLLALMAGDSAIQMENETDNELIQEATRILQNIYPNQMIPYPKETIITRWGKDKFCHGSYSYVGPEASGKDYDIMAMPVENTLFFAGEATCRTHPATVHGAYLSGLKAAQLVLDSLIGPLEIPANELLIPLKQKGVIDPSSRTKRKAQDDYKAQLAEFKDAQLEKHNKEVERVILERLGPRPSAPQRSTGNPFLVFQKSQWNYCKNIADKNKQKETGNPEAKATKNEIRATLGKTWRNLTDDEKKPFFDIVAENRLNFSNLIEEYNTIINEYNIKTEEIRAEMKARLDAIPISQEELELKRLAKEQDIQEKKIKAERKREQDLFEDDSSDSFDDDYQDNLRNDPSYRAATYLKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7PMQ0</accession>
    <name>M7PMQ0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAP-25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872034.1">
        <property type="nucleotide sequence ID" value="XM_007873843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PMQ0"/>
    <dbReference type="STRING" id="1069680.M7PMQ0"/>
    <dbReference type="GeneID" id="19893871"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00173"/>
    <dbReference type="eggNOG" id="KOG3065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020823_0_0_1"/>
    <dbReference type="OMA" id="TNQRMER"/>
    <dbReference type="OrthoDB" id="18679at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032120">
        <property type="term" value="P:ascospore-type prospore membrane formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15857">
        <property type="entry name" value="SNARE_SEC9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15886">
        <property type="entry name" value="SNARE_SEC9N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF9">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="2">
        <location>
            <begin position="252"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR11739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="315" mass="36941" checksum="41CBD34BA0165946" modified="2013-05-29" version="1">MENNKSESNISEKSTFGSRNPTFSGNSYNFLRNAGLFETNDTYEQSRSKLFETLPPKYEQHAFNSKYTSNLNNSHKFSSNDEYTPYNLEDSDNEDVDAIKQEMRFIKQNSLSSTRNAIRTAIHAEEIGRQTLERLGTQSEKIGNTEKHLDLANVTAKMAEEKNKMLNQLNRSVFIPHFSNPWKKQTRLKEREQYIRDQYELEQMERERTKRSDNESNRRIKEVLCKQKAKSFEKQTLNDSMRYRFEPDEEDNELENEIDQNLTQLGNITAQLKAIATATQEEILSQNNRLDRISDKGHKLNAEIHVNAERLRRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7PMQ4</accession>
    <name>M7PMQ4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA sliding clamp PCNA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_00178</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Involved in DNA repair.</text>
    </comment>
    <comment type="function">
        <text evidence="7">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processivity during elongation of the leading strand.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PCNA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872039.1">
        <property type="nucleotide sequence ID" value="XM_007873848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PMQ4"/>
    <dbReference type="STRING" id="1069680.M7PMQ4"/>
    <dbReference type="GeneID" id="19893876"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00178"/>
    <dbReference type="eggNOG" id="KOG1636">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043978_3_0_1"/>
    <dbReference type="OMA" id="EMKLINM"/>
    <dbReference type="OrthoDB" id="534348at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043626">
        <property type="term" value="C:PCNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035753">
        <property type="term" value="P:maintenance of DNA trinucleotide repeats"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000710">
        <property type="term" value="P:meiotic mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903459">
        <property type="term" value="P:mitotic DNA replication lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045739">
        <property type="term" value="P:positive regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045740">
        <property type="term" value="P:positive regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000006">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000008">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.70.10.10:FF:000001">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.150.10">
        <property type="entry name" value="DNA Polymerase III, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022659">
        <property type="entry name" value="Pr_cel_nuc_antig_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01251">
        <property type="entry name" value="PCNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00293">
        <property type="entry name" value="PCNA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="10">
        <location>
            <begin position="127"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR11744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="250" mass="27841" checksum="DD9C8F4DD5956D32" modified="2013-05-29" version="1">MLEARLQQASILKKTLDATKELVSDANLDCNESGIALQAMDNSHVALVAMLLRADGFEPYRCDRNISLGINLNSLSKVLKCAQNEDIITLKAEDTPDTLNMVFESPTNDRISEYDIKLMDIDQEHLGIPDTEYSVVAKLLSIEFQRICRDLLALSESVHIEANKEGIKFSCAGDIGNGSITLIQNQDTKIDLNEPVSLTFSLKYLVNFTKATPLADTVILSMSNEVPLMVEYKMEGGYLRFYLAPKINEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7PMZ2</accession>
    <name>M7PMZ2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00248</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872119.1">
        <property type="nucleotide sequence ID" value="XM_007873928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PMZ2"/>
    <dbReference type="STRING" id="1069680.M7PMZ2"/>
    <dbReference type="GeneID" id="19893946"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00248"/>
    <dbReference type="eggNOG" id="KOG2908">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042989_0_0_1"/>
    <dbReference type="OMA" id="SFEDYWE"/>
    <dbReference type="OrthoDB" id="1093at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054179">
        <property type="entry name" value="PSD13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035298">
        <property type="entry name" value="PSMD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22037">
        <property type="entry name" value="PSD13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="178"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR11824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="389" mass="45082" checksum="B2DF6C0F026FB8F1" modified="2013-05-29" version="1">MEIDTGIDISAFLGSQKVLMKDDLQKMISTMEDLWERRLWKQLTDILIEFFENPESASFRMDMFKFFVVSFSQHINKLKLVVLGLSASRQCKNNIESLEFLSFLLEKVNAPATKDAYVYASIETAHMKLLCGDLDGSFELLNKSSKILDELDSVDPIIYASFYRVNADYYKFKADYGLFYRNSLLFLACIELSSLSIHEQRQRAYDLSIAALLGDTIYNFGELLLHPILDTLSGTEHEWLRQLLFALNSGNILKFESLMEHFLKQPLLRSSIPFLRQKICLTALIEAVFRRSPHDCILKFSTIASETCLPEHEIEYLVMKALSLDLIRGFIDQVDEIVRITWVHPRVLDRNQICVMKKRLEDWYKSTHQLETFITNVGSNIIENEVIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWW3</accession>
    <name>A0A0W4ZWW3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_04328</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="KTW32868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613346.1">
        <property type="nucleotide sequence ID" value="XM_019757840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWW3"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZWW3"/>
    <dbReference type="GeneID" id="19896060"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04328"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="33"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KTW32868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="289" mass="32611" checksum="85A34F05B83EE265" modified="2016-03-16" version="1">MVLNKLFKLNTGGYIPALGLGTWQSKPDEVSIADTAFMYLNEEGVGQGIKNSGIPREEIFVTTKLACTFHSRAEECLDQSLNKMKLDYVDLYLMHWPLSLNPNGNHIFFPKKQDGTYDIEKGWDFLKTWKSLEKLLSTGKVKAIGVSNFSTVNLEKLLETAEIIPAVNQCELHPYLSQEKLLKFCIEKGIHLTSYSPFGSTNTPLLKEPMVTEIANKNGMTEAQVILAWCIQRGTSVIPKSVTPSRIISNLQVSELPEDDFLRLNELGKTHKVRYISLNKDITIFHDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWY0</accession>
    <name>A0A0W4ZWY0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_04303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="KTW32884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613358.1">
        <property type="nucleotide sequence ID" value="XM_019757821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWY0"/>
    <dbReference type="GeneID" id="30671587"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04303"/>
    <dbReference type="OrthoDB" id="3983163at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KTW32884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="63" mass="7454" checksum="07AB5583A1E8F91E" modified="2016-03-16" version="1">MIKIQSFSAQDIRKLLNKSHKSEEVPLMELIQYTCYVKEQKIICKSVRRFNKKNIIEVTGLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWY9</accession>
    <name>A0A0W4ZWY9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">26S proteasome regulatory subunit 8 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_04304</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="KTW32885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613359.1">
        <property type="nucleotide sequence ID" value="XM_019757822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWY9"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZWY9"/>
    <dbReference type="GeneID" id="19895692"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04304"/>
    <dbReference type="eggNOG" id="KOG0728">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="REPAVIF"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000006">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000068">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="173"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="12"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KTW32885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="376" mass="41952" checksum="90397A260559A57F" modified="2016-03-16" version="1">MGLASIYEEDITSFYTRKIEEAELQINEKTQNLRRLEAQRNELNAKVRLLREELQLLQEPASYVGEVIKTMGKKKVLVKCQPEGKYVVDIADGIDIKKLTAGLRVSLLSSSYTLNSILPSKVDPLVSLMMVEKVPDSTYEMIGGLDQQIKEIKEVIELPVKHPELFESLGIAQPKGVLLYGPPGTGKTLLARAVAHHTDSKFIRVSGSELVQKYIGEGSRMVRELFLMAREHAPSIIFMDEIDSIGSTRSEGGNRGSDSEVIMATNRIDILDPALLRPGRIDRKIEFPPPTLKARADILRIHSRSMNLTRGINLQKIAEKMNGFSGAEVKGVCTEAGLYALRERRIFVREEDFELAVSKVMNKAGISDVSLSKLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZX44</accession>
    <name>A0A0W4ZX44_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sensitive to high expression protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_04251</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SHE9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="KTW32945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613412.1">
        <property type="nucleotide sequence ID" value="XM_019757775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZX44"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZX44"/>
    <dbReference type="GeneID" id="30671551"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04251"/>
    <dbReference type="eggNOG" id="KOG1671">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HREEMKC"/>
    <dbReference type="OrthoDB" id="5595506at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008839">
        <property type="entry name" value="MDM33_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961:SF3">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05546">
        <property type="entry name" value="She9_MDM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KTW32945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="317" mass="37951" checksum="3D2BC7D0F1C3BE72" modified="2016-03-16" version="1">MRYSLFFISRDSKLFFFPKNRNITFFKPFISGSISLKDIIIKKNVSKHIQNYVSWIKTYFTSVEEKINQLTGYAKIEQLKCLISEQETNLKKARIETKEAKYKHTLAIQERLKLQREVNELLQRKHLWTPSDLERFTSLYRYDHVNEQEEQKAYADLIECESRLDELQVQLLHFMLRRYHEEQIWSDKIRRMSTWGTWSLIGFNIMLFLIIQLGLEPRKRNKLMNDLKQHFELLSEKNQVKSDMKEIAIQDSKNLENTYSLLSVESDRFQKKIALQYFHDVKKMFYGEPIEPKTVSILCISTAFLGATLCYIIQQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>M7NIF5</accession>
    <name>M7NIF5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cation-transporting ATPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_03193</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875256.1">
        <property type="nucleotide sequence ID" value="XM_007877065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NIF5"/>
    <dbReference type="STRING" id="1069680.M7NIF5"/>
    <dbReference type="GeneID" id="19896880"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03193"/>
    <dbReference type="eggNOG" id="KOG0209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001828_4_1_1"/>
    <dbReference type="OMA" id="WYYSLFN"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07543">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000071">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057255">
        <property type="entry name" value="2TM_P5A-ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047820">
        <property type="entry name" value="P5A-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23143">
        <property type="entry name" value="2TM_P5A-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1039"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1118"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1158"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="domain" description="P5A-ATPase transmembrane helical hairpin" evidence="14">
        <location>
            <begin position="2"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="13">
        <location>
            <begin position="239"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR08353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1206" mass="137839" checksum="76FFF722E1B8AB3F" modified="2013-05-29" version="1">MFHLYVFPFIFLYSFWIYIYKFKYDKYIKSEEWTFITLGTLFSVQGILWLSKHWNVHIKTLLTAKLCYRVEEAQLIRITPVSNQGLSEICVLNRKKFENEAFPEIYFFFQKKKFVYSYEKKKFQELSFRIDSNPLIEDLQAMRGLTSDTLINYAKDHYGYNRFDIPVLTFVELFKEHAVAPFFVFQVFCVALWCLDEYWYYSLFTLLMLILFESTVVWQRQKTLTEFRTMSIKSYQIYVYRKYCWTQVMTDELFPDDIVSIAPFKEEHDVPCDMILLSGTCIINEAMLSGESTPLLKENISLRDPKSSFDIQDVDRNSLLFGGTKILQISPSTNSAIPLAPDNGALAVVIKTGFETQQGNLVRTMIYSTERVSANNLESLFFILFLLVFAIAASCYVWTKGIQSNRNKYKLLLDCILIITSVVPPELPMELSLAVNSSLATLSKLAIFCTEPFRIPFAGRIDVCCFDKTGTLTEEDLVVKGVAGLSENPEELVDVNSVSKETMLVLGTAHSLIKLDDGKVIGDPMEKATLDALKWKLEKNNVVLSSQKELQESKIEIVRRFQFSLVLKRQSSIVTISDQIKKSRKTFVAVKGAPEVLEKISIVPKNYESIYRYFTKNGCRVLALGYKFLKDQINTSEINLLSREEIESNLIFSGFLVFSCSLKRDAASTIKMLNESSHRVIMITGDNPLTACHVAREVQIIERDVLILDSFNNGLDLCWKNIDNEIIASINVNSPLDKTIFQKYDICVTGYALSKYYNSNHINDLLRHTWIYARVSPAQKERILISLKEAGYITLMCGDGTNDVGALKQAHIGVALLNGSEEVLKRIEEHARNEKLKQIYEKQVKILAKFNKPPLPVPFPIAYLYSEGPFNPHREASILARSKNIEASKNNNKPNSNKTSQNKLQVSNITKKDENFTETLLSKFASFEDDTEPPVLKLGDASCAAPFTSKLSNVVAIANIIRQGRCTLVATIQMYKILALNCLISAYSLSVLYLDGIKFGDGQITISGMLMSACFLYISKAKPVQTLSKERPQSNIFNIYIIGSILGQFLIHILTLIYIKYYVSLFETPIKNVDLESEFSPSLLNSAIYLLQFMQQISTFTINYQGQPFRESIQENKIMFYGMLGVTGLAFSCSTEFIPEINEKLKLVKFETSFKITLTIIMILDYIGCYIVEYIFKKLFFDNRPKDIVKRISYHDVKKNNKNIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NIQ9</accession>
    <name>M7NIQ9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_03309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875385.1">
        <property type="nucleotide sequence ID" value="XM_007877194.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NIQ9"/>
    <dbReference type="STRING" id="1069680.M7NIQ9"/>
    <dbReference type="GeneID" id="19896996"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03309"/>
    <dbReference type="eggNOG" id="ENOG502SB89">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059021_1_2_1"/>
    <dbReference type="OMA" id="GDHEIWV"/>
    <dbReference type="OrthoDB" id="5587740at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050268">
        <property type="entry name" value="NADH-dep_flavin_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466">
        <property type="entry name" value="FLAVIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466:SF1">
        <property type="entry name" value="FMN REDUCTASE (NADH) RUTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="162" mass="18316" checksum="78E5555C19D81BE2" modified="2013-05-29" version="1">MKCLVQPVVIITTCDPKMNGLGRAITVSSFSSISLNPMPIVSFSIKLPSRMALLLRKSRKFAVHILKSHCDQIKLAQKYAQSDIFNKNKMSNISESHYQISLNKLPILSGALGILYCNTNKTIKIGDHKIWFGTVEYVENKDVFQKMSLSYCQGDFRIIKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJ81</accession>
    <name>M7NJ81_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02855</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874893.1">
        <property type="nucleotide sequence ID" value="XM_007876702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJ81"/>
    <dbReference type="STRING" id="1069680.M7NJ81"/>
    <dbReference type="GeneID" id="19896542"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02855"/>
    <dbReference type="eggNOG" id="KOG0880">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_4_2_1"/>
    <dbReference type="OMA" id="ENHEITH"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000001">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006528097" description="Peptidyl-prolyl cis-trans isomerase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="30"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="198" mass="22284" checksum="AB82ED3275413454" modified="2013-05-29" version="1">MKCLIFITLIGMFIFQCFAAKGPLITNIVFFDVEYGGKYLGRIEFGLYGKTVPRTVENFRVLSTGEKGYGYQGSKFHRVIKNFMIQGGDFTRGDGTGGKSIYGDKFSDENFKLRHRKPGILSMANAGKDTNGSQFFITTVETPWLDGKHVVFGEVINGFDIVKKIEGCKTTYNDRPEVDIVIIKSGELHVNEPFHREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJJ3</accession>
    <name>M7NJJ3_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_02933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874978.1">
        <property type="nucleotide sequence ID" value="XM_007876787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJJ3"/>
    <dbReference type="STRING" id="1069680.M7NJJ3"/>
    <dbReference type="GeneID" id="19896620"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02933"/>
    <dbReference type="eggNOG" id="KOG1938">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014185_0_0_1"/>
    <dbReference type="OMA" id="KLADWSM"/>
    <dbReference type="OrthoDB" id="203724at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12739">
        <property type="entry name" value="TRAPPC-Trs85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="593" mass="68150" checksum="AABB1E9675095A43" modified="2013-05-29" version="1">MNRYFMGNFSEKRASEDGYITHLSEKYQKNSFLPLFLRGFSPNIAVLASGDANELASAKGFGCVHEMLSIFEENKGETVLIRHSEGNVLCEVFGVHFVPLQRLLNDKKIHEEIKSMEEEIDWMEGKVSEYMNVFSYGMKDMKEEKILKENERDLEKTYENPENMEQSLEISSAFHFYCRLLASFPPSVHESFSHPIACVFAISSHSSKPLESLQHLQLHPPMLPYIDFSYLPACLFLHDDSHDLEKSLQVFETIKQTFGIHSYLIRLSPSDQSLDKSQEAYIRVPKDPWNLSFDTTKDEFYALSQKDVSAIRTFVKELISRSIIPAMEQSIDLWNEQVAASRRGIAGKLLNVSKRYFSTGTARNQSSFYNNSNYNIKTLSYDLSSPEARLRKLADYAFMLRDWKFAQSIYELLKKDFLNDKAWKYYAGVQEMLALCSLFPSYTTKIKVETIDSMLNASLYSYLSESSSPFFALRSVIFASELMFLQSNEAKNNAAKWLIKILETGILGNTINALLIERISYCFGTIRSYGLLSYGSRRKKAALWKILATEAWLTLGKKKLAQQSFLQAMSVYQDTQWNEINAFTATLHDQIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJU6</accession>
    <name>M7NJU6_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874699.1">
        <property type="nucleotide sequence ID" value="XM_007876508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJU6"/>
    <dbReference type="STRING" id="1069680.M7NJU6"/>
    <dbReference type="GeneID" id="19896367"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02676"/>
    <dbReference type="eggNOG" id="KOG0941">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052729_0_0_1"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052830">
        <property type="entry name" value="RCC1_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46849">
        <property type="entry name" value="RCC1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46849:SF1">
        <property type="entry name" value="RCC1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="168"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="331" mass="36861" checksum="6D47F85D78143217" modified="2013-05-29" version="1">MEIWGSGCNIFGQLAKHEQPYLFELKLIQQVDKGNIDIIFNGWSEILYSINGCLKLLGFRADDIDIYFPDSILCVFGTIEISGIVDSEFNLRDLKGNILQKGIGIVVEAGNGQFVGTDYSYKNLIFFDTKDRRFDICNIFPLKLKDENSKILQISAGASHFALLLSDGEVYTWGDNIYGQLGRETSDDLESNIIPTIVSALQGLKIQKIAAGGWMTGAQSADNDLYICGWLKLGKIVNTSDNKSEFNLVDLGENVDILDFGIGSEHIVVLTTNGIYSLGKEGENCLSYSNLIWIQIPQFSNKKITHVFCSQWNTLLIAHDESTIEKDNLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NKA6</accession>
    <name>M7NKA6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02838</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874874.1">
        <property type="nucleotide sequence ID" value="XM_007876683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NKA6"/>
    <dbReference type="STRING" id="1069680.M7NKA6"/>
    <dbReference type="GeneID" id="19896527"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02838"/>
    <dbReference type="eggNOG" id="KOG4210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_366423_0_0_1"/>
    <dbReference type="OMA" id="GGFKKHN"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12447">
        <property type="entry name" value="RRM1_gar2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12448">
        <property type="entry name" value="RRM2_gar2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034276">
        <property type="entry name" value="Gar2_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="530"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="632"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="725"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="341"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="409"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="435"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="457"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="491"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="741"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="761" mass="83399" checksum="4BDF471A21121301" modified="2013-05-29" version="1">MAKSSIKKENKNTNEEKRVHKIPAKKGGVSKPGVSKEQTKSTIKSIKKELEKKKKNEDYSVMKEPRKNYSSSSLGGLEKKSKIASEAPSKLRSEELHLKKFKEKKNSSESSSENLSESSSKSSSKESLVKVPSSRNSSEDSDSEDSSESSSSENLSENLKLSGNILKKTDISGSSNDSSSSDSSNSSNESCLSDESSSDDSSSDLDSNSDSNSSSDDSNSENSLKSSTSIDSTVKKMQETKEKVNSGVGPKKRKTETKVENLTKKSGQNPIENKTERINIQKYNENQDDELSDVEKLNSNESYNNRLIDNKKMKDDEDSSDSDSDSHSTSNNNDDSDDNKNSTSTDGFHTINDSNNNSAGDSDDSTSSSTSSSSGDSSDLTSNSSGDSANNVVTDSTSDSETQSDTNKNAKHSTKNTFSKKKNKETKIPLENVSKNKNINDNFSKSKNISKKNKHVSKTENFDNIDDKLEKEISDFSPHDSAKKLSDNKNIKHKDNKNTSKKRKDAPIEIDKKETKKNKTNTGQDAEGSKTIFVGGLSWNVDDNWLAKEFESVGTVLSSRVITNKNSGKSKGFGYVEFSTPEEAQAALTYSGKEIDGRVINVDISTGLSANLKNNASTRANKYGDIRSPKSDTLFIGNLSFKANEEAVRTAFSRIGGIVEIRLPTNRKTGQLKGFGYIQFSSIEDAEKAIEMNGHFISGRPIRLDFSTKKNNNTAHATFNNSLNNYKKKDHKAPQRANFGGKTNSTNRSGFNEFSGKKTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NKJ8</accession>
    <name>M7NKJ8_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02508</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874518.1">
        <property type="nucleotide sequence ID" value="XM_007876327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NKJ8"/>
    <dbReference type="STRING" id="1069680.M7NKJ8"/>
    <dbReference type="GeneID" id="19896200"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02508"/>
    <dbReference type="eggNOG" id="KOG1953">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002231_0_0_1"/>
    <dbReference type="OMA" id="EHSRDRM"/>
    <dbReference type="OrthoDB" id="27962at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058565">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058567">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058568">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058564">
        <property type="entry name" value="TPR_TRAPPC9_Trs120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058563">
        <property type="entry name" value="Trs120_TRAPPC9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26254">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26280">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26282">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26283">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26251">
        <property type="entry name" value="TPR_TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08626">
        <property type="entry name" value="TRAPPC9-Trs120"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 N-terminal" evidence="3">
        <location>
            <begin position="12"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 N-terminal" evidence="3">
        <location>
            <begin position="149"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 TPR region" evidence="4">
        <location>
            <begin position="250"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 first Ig-like" evidence="5">
        <location>
            <begin position="534"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 third Ig-like" evidence="6">
        <location>
            <begin position="883"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 fourth Ig-like" evidence="7">
        <location>
            <begin position="1075"/>
            <end position="1185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF26282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF26283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1192" mass="136717" checksum="629B2D90D1B029E8" modified="2013-05-29" version="1">MYEFMVKNEVCYEWLETFEISRKIWVILSVFDAKKEGWKEGIEREIKWIGKKYKSVSVIRFLVKNLPLEEKMDGIEVIGLSDKGEMEEKSWRDLVYNITYSLLKEFEIFARKIQEKMWIESPYVSKFGEKAEEMNEYEEKMEKIGGTLLKGRKIKILGDLYLLSGCTLDALKKYTESAMLAKASKDYIWHGSALEGIGVCLVVLSFLQIEYQIPITALPSSPPQLDKIGSTKMMTFKEIDLNVSKPHVLDFLLDLHMNIIDLYQKSYNCSNERVPTLCFSESVLRFGKLLSLVHLAGGWNHIALRSIIYDEFYLIPKTRVSGYPPKADIASWSMRAHSPYVNELDVVDKCRIYGGLASILGMVGFRRARAMFLREIISTLTPVLINSKVDWITDDSVRLIAQIALTNYSISPKHSNMQNSSFLIHNLLDDLCDCYGILRMDERCKSRSEVELLEKYGWPSLKITILKECISFCEALPDFSGVLNFTTKILSIASIYLSRDNQIRFASNIPRIILAVRSLGLDELEADYWDRDIVQSIEFIPGSSKFTPILYSGSELDSVDKDNNYPRDPFIYNPFIKKSNIPVKHLLVEGDVAEFKIVLHNPLSFELECVGISLFTEGVEFESQSTSVVIGPQRIHIVRLFGCPKEPGEFVVKGCRIHLSGCKDDIFLVNRGLSSVEHEKLFLNVFYEGKIKSMGLNVYSVIKSSIMSLKNGEIPLKNTLSSIPMTIEESFEVLPAQPILIVTRTSLVNGSIMLLEGERSTFTITIKNVSHITINFLLLSFTDSTINPLKDALASKNISREEIYELELFLYKRQAFVWNKKVSHFSLKPDCEEVLEIEIFGKRGLTDGKIQIDYGNVENDSSHGRFYTRRVVVPVIVTVNASLELVNCDVINIVNDIKERENIPDISEEMGSLFQYAGTHEHEGVEYCLGLLDFRNIWPKPLCVYLNVQNEGDELFKIEKLIYPGETNRLIFPLKRIYISREDSQKPIPIVSTRQFVVSNTKKDSEVDDYQQRESFWLREALFRIIDGTWVQPGADRKGVVELRGLRMTPKMVYSLKVEDISVVLEISGVVKKIQRLTWLVKLYEFVTFTLKIINRKEYPIKTLVRIQPSLRYQNQTLVDLSRCVTFNGIMQTVLPLIESQQSHEEKYTAVFMNRGEYEIMASIQELYGPDKGRMHVSRNHLIVKCVDDIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7NKY3</accession>
    <name>M7NKY3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Poly(A) polymerase</fullName>
            <ecNumber evidence="13">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PNEG_02263</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Polymerase that creates the 3'-poly(A) tail of mRNA's.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium ions. Also active with manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="13"/>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874252.1">
        <property type="nucleotide sequence ID" value="XM_007876061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NKY3"/>
    <dbReference type="STRING" id="1069680.M7NKY3"/>
    <dbReference type="GeneID" id="19895956"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02263"/>
    <dbReference type="eggNOG" id="KOG2245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011511_4_1_1"/>
    <dbReference type="OMA" id="PAYPAMC"/>
    <dbReference type="OrthoDB" id="412748at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071920">
        <property type="term" value="C:cleavage body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033620">
        <property type="term" value="C:Mei2 nuclear dot complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990251">
        <property type="term" value="C:nuclear exosome focus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033621">
        <property type="term" value="P:nuclear mRNA surveillance of meiosis-specific transcripts"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031126">
        <property type="term" value="P:sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.590:FF:000003">
        <property type="entry name" value="Poly(A) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000002">
        <property type="entry name" value="Poly(A) polymerase alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014492">
        <property type="entry name" value="PolyA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018425">
        <property type="entry name" value="PolyA_polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="18">
        <location>
            <begin position="14"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="17">
        <location>
            <begin position="213"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="16">
        <location>
            <begin position="359"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="106"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR018425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMR09303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="576" mass="65867" checksum="7C6FD448F12020E9" modified="2013-05-29" version="1">MNTTGLSLNGRQWGVTPPVSMAGPTEQEIMINGALIDELKRRKNFESPEESDKRARVLGELQKITLEFVQKVSLDKHMTENMARDAGGKIFTYGSYRLGVYSPGSDIDTLMVVPKHVTRENFFTDFEQILRNRPEATEITAVPDAYVPIIKFKFCGIPIDLIFARLALSQVPMDLTLEDNNLLKNVEERCVLSLNGTRVTDEILRLVPNPTIFKHALRAIKLWAQERAIYSNVMGFPGGVAWAMLVARICQLYPNAVSAVVVAKFFRILSQWKWPQPVLLKPIEDGPLQVRVWNPKIYKGDQAHRMPIITPAYPSMCSTHNITESTQKVIINEMNRAGDIADKILIGSLPWSKLFTKHTFFHQYKYYLVIIAASKNAETQLKWSGLVESKVRQLVLRLEYVDEIKLAHPFNKSTDLVHYCKTEEEANGVARGELTATKMENINMQQTAKEMESISNRDIENAQNNLILVYTTTWYIGLEVDKKDGSKKLDISWPSQEFYEMCRKWDKYNIETMNVVIKHIRNFDLPDNVFVEGEQRPVRTLKKIKKRKLQSDEKKDNISESPDKAVKIESAVSIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLF3</accession>
    <name>M7NLF3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trafficking protein particle complex subunit 6B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875559.1">
        <property type="nucleotide sequence ID" value="XM_007877368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLF3"/>
    <dbReference type="STRING" id="1069680.M7NLF3"/>
    <dbReference type="GeneID" id="19897158"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03471"/>
    <dbReference type="eggNOG" id="KOG3316">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076409_0_1_1"/>
    <dbReference type="OMA" id="CKEFWTA"/>
    <dbReference type="OrthoDB" id="941624at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14944">
        <property type="entry name" value="TRAPPC6A_Trs33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817:SF0">
        <property type="entry name" value="GEO08327P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="22114" checksum="2EFF99856A2A380A" modified="2013-05-29" version="1">MQVDPHAIFVSSSCMDLLLIEMIPIMKRLTLTTMSSPQVRRDLSFEASSLVAIQHEDDEREAIYGRLELLGFKVGQRLVERFSQNKSRFMEPLDMIKFICKDIWMLLFKKQIDNLKTNHKGVYVLTDYSFSWFLRMSTKIGGQDAINKAQIFLWFPCGMLRGILTNLGEQCTVIADTTNFPGCTFQIKLINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLF7</accession>
    <name>M7NLF7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Replication factor C subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_03475</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875564.1">
        <property type="nucleotide sequence ID" value="XM_007877373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLF7"/>
    <dbReference type="STRING" id="1069680.M7NLF7"/>
    <dbReference type="GeneID" id="19897162"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03475"/>
    <dbReference type="eggNOG" id="KOG0991">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042324_0_2_1"/>
    <dbReference type="OMA" id="SCNYSSQ"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000012">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000015">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF5">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25361">
        <property type="entry name" value="AAA_lid_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="6">
        <location>
            <begin position="2"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Replication factor C C-terminal" evidence="7">
        <location>
            <begin position="182"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="282" mass="31622" checksum="CCA5338C6CB5077E" modified="2013-05-29" version="1">MPGIGKTTSVICLAQKMLGDSFNEAVLELNASDERGIDVVRNRIKGFAQKKVNLPLGKHKIIILDEADSMTPGAQQALRRIMEIYSNTTRFAFICNQSNKIIEPIQSRCAILRYSKLSDQQILKRLLEICKSENVKYSDDGLSALIFSAEGDMRQAINNLQSTVTGFGFVKGENVFKVVDLPSPGAIKSIINNCKKGDINVALETLKDLWNMGYSALDIITTFFKVVKMMDELPEYTRLEYIKEIGTTHMIILEGVQTPLQLYGLVARLTKKNMDPKYFIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLF8</accession>
    <name>M7NLF8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bud22 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02086</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874066.1">
        <property type="nucleotide sequence ID" value="XM_007875875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLF8"/>
    <dbReference type="STRING" id="1069680.M7NLF8"/>
    <dbReference type="GeneID" id="19895780"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02086"/>
    <dbReference type="eggNOG" id="ENOG502S6Z4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029647_1_0_1"/>
    <dbReference type="OMA" id="ALWEKKF"/>
    <dbReference type="OrthoDB" id="3364872at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037393">
        <property type="entry name" value="Bud22/SRFB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015158">
        <property type="entry name" value="Bud22_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325:SF1">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09073">
        <property type="entry name" value="BUD22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bud22" evidence="3">
        <location>
            <begin position="31"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Bud22" evidence="3">
        <location>
            <begin position="203"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR09498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="350" mass="41059" checksum="DA8767D9EFED82E0" modified="2013-05-29" version="1">MNLQYGINQVSNIENLDILRKKINPKLFFFKKEVLRALKKARRFEFQKISKRIRNERPTNNITILDRLKEELLVVKNLNLEAIRDFLLYINCLKEPLLFQIIHLEPVNSPLKNVSESVKNVITRLFNSNSIKKCIKRVIFSLKKIAKIQDETMKPKNPQKNKKNSFEDPSILNNKLRGTEKGNSKSLNVKNKEKNIDILEEKVELKIKNHIQLKPKKKRINLEEKLKNLSGSTFLPSLSTGYISGSDDNNNIDPEYKVIDKPKKNRRGQRARRKIWEIKYGKNARHLQIKRKKLNSNKNIKLSYNNKNSALVSKNNKETKPLHPSWEAARRLKKKESSNIKFEGTKIKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLV6</accession>
    <name>M7NLV6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_03350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875431.1">
        <property type="nucleotide sequence ID" value="XM_007877240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLV6"/>
    <dbReference type="STRING" id="1069680.M7NLV6"/>
    <dbReference type="GeneID" id="19897037"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03350"/>
    <dbReference type="eggNOG" id="KOG0834">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022000_4_0_1"/>
    <dbReference type="OMA" id="MYDMMKY"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070691">
        <property type="term" value="C:P-TEFb complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20545">
        <property type="entry name" value="CYCLIN_SpCG1C-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20546">
        <property type="entry name" value="CYCLIN_SpCG1C_ScCTK2-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000072">
        <property type="entry name" value="Cyclin Pch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036580">
        <property type="entry name" value="Cyclin_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="41"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="154"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="324" mass="37760" checksum="F83A457088C2DDB5" modified="2013-05-29" version="1">MGYSSYKGKWYFDKEDFKYTPSVNDGWSLEKEQIDRGKGVNFIIQVGARLKLPQLTLSTAAVFLHRFYMRFSLAKYHYYEIAATCILLATKVEESCRKLRNIIIACAKVGQKNPDLVIDEQSKEYWRWRDVIIYNEEILLEALCFDLTIDHPYKDLLKYIKHFGSKQDTAKSAWAFINDSIRTAIPIIYKPHIIAAAAFYFGTKHTSTVINSIGNRSWWEVIDVDINEIKEVCKIMTNLYESIPMRGLYPALQSDTTKVPLQNDFPKTSDQTKELFHDQSKGVKRKNEDSFILNTSKDQNKVVFKKKLDELKNNDHQNIKKQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLY1</accession>
    <name>M7NLY1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UDP-N-acetylglucosamine transferase subunit ALG13</fullName>
            <ecNumber evidence="2 7">2.4.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Asparagine-linked glycosylation protein 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ALG13</name>
        <name evidence="9" type="ORF">PNEG_01866</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 7">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UDP-N-acetyl-alpha-D-glucosamine = an N,N'-diacetylchitobiosyl-diphospho-di-trans,poly-cis-dolichol + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23380"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19510"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57269"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.4.1.141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1 7">Heterodimer with ALG14 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.141" evidence="2 7"/>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873839.1">
        <property type="nucleotide sequence ID" value="XM_007875648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLY1"/>
    <dbReference type="STRING" id="1069680.M7NLY1"/>
    <dbReference type="GeneID" id="19895560"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01866"/>
    <dbReference type="eggNOG" id="KOG3349">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085408_2_2_1"/>
    <dbReference type="OMA" id="QYKFRPN"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052474">
        <property type="entry name" value="UDP-GlcNAc_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47043">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47043:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 28 C-terminal" evidence="8">
        <location>
            <begin position="6"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="168" mass="19066" checksum="4E15E7619E9BA12B" modified="2013-05-29" version="1">MVENKTVLVTVGSTRFDALILNIQKKSVQNALISQGFSKIVVQYGKSEDIFNQWEPINGMEVSGFSYSKDIEEEFQKSSLIISHAGSGSIIEALELKKQLIVVVNETLMDNHQKELTQIMTDQKYLISSTPENLLYAIQDLNKKELQPFLFSNEPTFQKILDNQMGFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMM2</accession>
    <name>M7NMM2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isopropylmalate dehydrogenase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01687</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873650.1">
        <property type="nucleotide sequence ID" value="XM_007875459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMM2"/>
    <dbReference type="STRING" id="1069680.M7NMM2"/>
    <dbReference type="GeneID" id="19895381"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01687"/>
    <dbReference type="eggNOG" id="KOG0785">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_4_1"/>
    <dbReference type="OMA" id="SHACWEM"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF34">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR09928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="100" mass="10385" checksum="400C8C445C535339" modified="2013-05-29" version="1">MCSGLVGGLGLTPSANIGIDASIFEAVHGSAPDIAGHNKANPTALLLSSIMMLRHMSLYKYADKIESAIFNVLSLGKTTTCDLGGQASTQQYTQAIVDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMN3</accession>
    <name>M7NMN3_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_03313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875389.1">
        <property type="nucleotide sequence ID" value="XM_007877198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMN3"/>
    <dbReference type="GeneID" id="19897000"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03313"/>
    <dbReference type="HOGENOM" id="CLU_2110018_0_0_1"/>
    <dbReference type="OMA" id="PQKETEW"/>
    <dbReference type="OrthoDB" id="2253354at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035213">
        <property type="entry name" value="DUF5321"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17254">
        <property type="entry name" value="DUF5321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="115" mass="13456" checksum="42205C40FB1FCDF1" modified="2013-05-29" version="1">MTTRSTISKKETKLIKKSFNSNIIFIVLLIILGSQANNILSIKQEFNEFETQIDAKISHLRDLIDRIQRGENLDISKELGTGIEEKEKEWSKVIEQVINEDDQWEQIKIRKREKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMQ4</accession>
    <name>M7NMQ4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proteasome activator Blm10 mid region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02995</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875044.1">
        <property type="nucleotide sequence ID" value="XM_007876853.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NMQ4"/>
    <dbReference type="GeneID" id="19896682"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02995"/>
    <dbReference type="eggNOG" id="KOG1851">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000772_3_0_1"/>
    <dbReference type="OMA" id="ECTQLVP"/>
    <dbReference type="OrthoDB" id="17907at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032372">
        <property type="entry name" value="Blm10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055455">
        <property type="entry name" value="HEAT_PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16547">
        <property type="entry name" value="BLM10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23096">
        <property type="entry name" value="HEAT_PSME4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome activator Blm10 N-terminal" evidence="3">
        <location>
            <begin position="24"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="2">
        <location>
            <begin position="350"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4-like HEAT repeat-like" evidence="4">
        <location>
            <begin position="1310"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1721" mass="201635" checksum="1409C4475DC19A2E" modified="2013-05-29" version="1">MHTCTQFSKSKPPNNRDPIFEPKNEHKKTFLYREILPYNIENKEKQLENLEKITKNIYISLAANDFSKAAIFSKEINNWLNLKFDLPRQIRIKLVNVYYELCTTEGISPNNQRRFESLFLSLTKRHHYLSIHDISLDWKPAFLILKRIMFPNDEAFIESRAISNSNNISIIPIIKKARLYFLPKEIPNILNELLPLFNTSIISDAFIVIGMLNLFLPCHPSPNDDPKLDPQYWLPAIFHLWFLISNSNQCSSIFLDLLGRLAKESHPAPTRAPCLFTDNQLSYIFTTILRLFNIPIGNIKNPILNNIDLHEGIPFIQQKSFTKQAAKLIIYSISPLCLIKKKETKVLSKLKTLIKSIETYFHPSNHGPWTKNLSKFIYYLSNYFVDRWNKENDKELDILPEKKLNIGIRKEFVLTLRKVTFMIIYSQDYEVMEQSQITLQNLSYLEPSFILPCILRRIYPSMKGLIETHRTISSLQSLCILAPIISGTKIFKNHITSLLNLVLPYIDANDLDKAAYSLTFISRVAQNVPFHDLTENANYEIALNWIENELNKFENVINDDDDLLLESYNYNDTEVNNVDDNLIAKSSTAFFHEFIIIFLDRIFTLLKNLSDQTSTKTKSSENHIIEILPSTLTHFFASLSDNFFKLALEKIIHFISNNVLYQSIHSVNFLCSSCISKNPKLFFEKLFPILKTNILFEIENNEAASTRSTGNDIHPRDRALLWNLQILSTSINGTGNILISYGTDLEEILNILIEKSKGNIITHVGNFFSVILSNFTTIYPIDKEMFEDNTEKYQNIQPDYWAHKTDPKKLNIKWHIPSEDEITFSVNLFIYQSNKILKDLSYLMQTCTKSTFKTRKEWSDNVTKCVFYLKKGLFGIAFLFDSDFNEIKDENSQEDEGTGIMHKYPSGYFFEKRKDDPRYVQILQIKKEIGNTLHNLHAFLTKYHNDDIQCFKSLISTLKTWLLDVLYCRTANVLDNLIRSYTHDIQPYKISGLRKKYPRILLIKRAEIYHITRLKFNSRYRNMTSLDILLLEDLVCSCLNFYSEIRRCAQNTLNIALKIMTNSKNIIIPPLLNAMLSSDIEVLKGAIYSLSMLKHFKRVIMDNWDFILKYIHGLIYIMKFDILSLKKICNKAYVDFIITFKSHSKVTLYKKNFLNLIKPTDDVNIKVITLIKKVNEKHKYICNEIKKLRHKLIDIIKDTHWRTSAMIGTGLIKILVSVENPPDDKLVSSIIRESISEHPLLRLLYIESLTFFLSILWQHGLTNGNLKAILLEEVHLPTRILHHVSLNQQNVKIYTKKFLSDFSNPAKDHFIDTLQYGWLIWPKAYPIYLTKKESQFLQLNSFTKKTFDKTIHLFSETWFEQFFNHLKQESRQESPKFRVIIATFMKFLFQIIKNVPCHITLNNLKGKIEQLCIPENEKHEIRAGCEILSGLVSSLKCESLEYCNEVWEWMLPIVKKNFENITPETLIFWLNFVKFSFSKRDPRRSWPFLKMLISFRLDKKSDLAFKETAKIALLRKAITHCGWHFQFANLIIENLLFHLDHPYKRVRDEIGKTLYIITSSEYHESFCNAESFIEYQYQNQNSYMTIPYISSNHFKNVIKKIFSQLKDRKSEYILNSNSVSYISCSKTILSWLQYSLNKTEYTLIVPYIPETILPEIVFMLNIKEDHDLLSSTHQILQQIGDIYFPTHLLHSMTNSIIEIMISSENWHHKLNIFPLLQTFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMU8</accession>
    <name>M7NMU8_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01764</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873730.1">
        <property type="nucleotide sequence ID" value="XM_007875539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMU8"/>
    <dbReference type="STRING" id="1069680.M7NMU8"/>
    <dbReference type="GeneID" id="19895458"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01764"/>
    <dbReference type="eggNOG" id="KOG2175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004909_0_1_1"/>
    <dbReference type="OMA" id="ALMTHNN"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055236">
        <property type="entry name" value="EVH1_PP4R3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006887">
        <property type="entry name" value="P4R3-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051137">
        <property type="entry name" value="PP4R3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318">
        <property type="entry name" value="ATP SYNTHASE GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22972">
        <property type="entry name" value="EVH1_PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04802">
        <property type="entry name" value="PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PP4R3 EVH1-like" evidence="4">
        <location>
            <begin position="24"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central" evidence="3">
        <location>
            <begin position="168"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR10008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="802" mass="92686" checksum="749EF2728504F99A" modified="2013-05-29" version="1">MSDLEANKGDEKALKDVKVPQNPHRVKVYEMRDENWHDCGTGYCTAMIDNETDGYFVVKSETNEEEVLLKSKIVREDLYQIQQKTLIVWKELDGTDIALSFQEIEGCDEIWNFLSDVRRALSLAYVLKPSSTELLNDQVDQFFSDDVVEQNTSSPIYLPVPELRNLAEIEALILKANQTVLGKESLAKFVLNENYIMQLVLLLDVCEDLEILNDLHLLCSIMKNIILIDDAAVIEYILRDDIILGVVGILEYDPDFSNHKANYREYLSDTSKFKQVVDIKNPEIRNKIHQTFRLQYLKDVVLARIIDDLTFSILNTLIFFNQVDIIQHIQHNNEFLEELFGLFKDDSIELSRKLDAVVFIQQVCNVAKTLQNPSRISLYMTFVENGLFDVVLFALRSQPLICIAGAEILMAIIEHDPGYLRSFILNQIDKDDKSLLDVLINLLHDETDLGIKAQISEAIRILMDPTSVSSNTFLKLNESAQKSNDSDTDKFLQLFYDKSAKFLFEPISNINSSIKEFSLISSALLVHLCELLCFFVKVHSFRSKFFILSSNISCKIAFLFTFPQKYIRLASLRYFRTCIGLNDEFYSRHFIKNNLFSHVLTVYMETNRYDNLLSSACLEFFDVIRKENMKSIINHLIESSYEKIKSLNDIPVFDQLIKKYEQYHDKSYEFESVKNEDTKHGPTGRWVRTETVDIEEENYFNTSDDEDNVDLEKGEGSIRKLVNYPDDDIEVYEKTDLNIYYDRNIDSSISFDKITEKRYRDDDDLGLLTRVKRNSVSDINSTSQSSLKKISISIGNLGKTNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMW4</accession>
    <name>M7NMW4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Palmitoyltransferase</fullName>
            <ecNumber evidence="12">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_01777</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="12"/>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873745.1">
        <property type="nucleotide sequence ID" value="XM_007875554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMW4"/>
    <dbReference type="STRING" id="1069680.M7NMW4"/>
    <dbReference type="GeneID" id="19895471"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01777"/>
    <dbReference type="eggNOG" id="KOG0509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012510_1_0_1"/>
    <dbReference type="OMA" id="FWVGFRY"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="15"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="82"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="13">
        <location>
            <begin position="378"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR10023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="653" mass="75700" checksum="A2381897C50DB0BB" modified="2013-05-29" version="1">MCKSGEVMPNISDDQGVTALHWASISDQLNVGRYLLLNGVDVNVQGGELCATPVHWAAKKGHVYMVDMLYQSGASLHLTDLQGFTALHLATHRSSVMLVLYLLHQNVQIDCLDYRGHTPLMWAAYNGDISIVDILLRWGANVKLQDKQGMTALHWAIVKGKYFCIFTSILMVFLGDKLCIKKLVEFGSDLLVQEHNGKTAEKIAEEMNRTALWKSVLKEVGRDASGKLKRRLLGFKSSNVVLFFAPFFVFGFLFWIFTIFPVFLSIPLAFSLSIGFHLFFVKVISIEYDTFLTIHKTKYFSGIFFGTLVWVILRWIFVLLQNTWKNSPFFNILFFIVACFSIIFFFYVMFSNPGYIPKPQGIKEQREVIEDLIKERAFDRQHFCIFCYLRKPLRSKHCKVCSRCVARFDHHCPWTGNCIGLRNHRLFIVYIIMVQIGIVFFLRLLLIHFEVLYSPELSKNCFVFLKLLCEPFLLDPFTFVLALWTFLQLIWVTLLLVVQLFQISFSITTSEARNLDKYGFMGEIEKDFYRKDAAYILRSTFSNDDAPHHHYCSHKKGYRMFSMLSKFLGIHHFLKIISIFSSKSVSLMNKTKNPFNNGILSNCRDFWNCGTGKISVLGFMNKTKHSYIEGSGYIDGQLINYYYLYDYLRFHKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN39</accession>
    <name>M7NN39_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">6-phosphogluconolactonase</fullName>
            <shortName evidence="6">6PGL</shortName>
            <ecNumber evidence="4 6">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01382</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="4 6"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873317.1">
        <property type="nucleotide sequence ID" value="XM_007875126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN39"/>
    <dbReference type="STRING" id="1069680.M7NN39"/>
    <dbReference type="GeneID" id="19895079"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01382"/>
    <dbReference type="eggNOG" id="KOG3147">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053947_0_1_1"/>
    <dbReference type="OMA" id="IAMSQST"/>
    <dbReference type="OrthoDB" id="432544at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000005">
        <property type="entry name" value="6-phosphogluconolactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="7">
        <location>
            <begin position="9"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="252" mass="29167" checksum="9B0B30D096BAA512" modified="2013-05-29" version="1">MATLYSFQTKDDLRNALYQYIKKAYNESIIKHNKFNVAISGGSLPKILGENIENLNGIDWNKWEIFFADERVVPLYSQDSNYKLCYDEFFMKLPIPMENIHTIDVSLLNNPEKLSKAYESVLMRKFPIKNTKKFPEFDLLLLGCGEDGHTCSLFPNHKSLQENTSWVISITNSPKPPSTRITFSLPVITNAQRIAFIVLGEKKREIMKRIWNYIEELPCSLINIKAGCKVLWFSDISATELVDEKIKKQFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN51</accession>
    <name>M7NN51_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit F</fullName>
            <shortName evidence="4">eIF3f</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01392</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit F family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873327.1">
        <property type="nucleotide sequence ID" value="XM_007875136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN51"/>
    <dbReference type="STRING" id="1069680.M7NN51"/>
    <dbReference type="GeneID" id="19895089"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01392"/>
    <dbReference type="eggNOG" id="KOG2975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027018_0_2_1"/>
    <dbReference type="OMA" id="EYFVHFH"/>
    <dbReference type="OrthoDB" id="25498at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08064">
        <property type="entry name" value="MPN_eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03005">
        <property type="entry name" value="eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027531">
        <property type="entry name" value="eIF3f"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF6">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="28"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="302" mass="34400" checksum="B74467052C13EC10" modified="2013-05-29" version="1">MVSEMGILLYPEKLTGSYISPIFNTVNVVLDPIVLFLILDHSLRRNHGQDRVIGTLLGIRSEDGSEIEIRNCFVVPHNENQDQVEVDMEYHKTMYDLHRKTNPHEVVVGWFATISQLNTFSALIQNFYSSSSDGTYPFPAVHLTVSFDFKAGINCKTYISSAVGVTSERTVDSCLFLPIPHEIRYYDFERNGFDSILKAKNEESRKTSILADMDNLEQSIEKILSILKKVKKYVENVMDGKNRSNPAVIRFLMDNVNVSPNIDMLDVEKMFNNHLQDVLMLVCLVNIIHIQLDIANRLVALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNT0</accession>
    <name>M7NNT0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01602</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873559.1">
        <property type="nucleotide sequence ID" value="XM_007875368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNT0"/>
    <dbReference type="STRING" id="1069680.M7NNT0"/>
    <dbReference type="GeneID" id="19895297"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01602"/>
    <dbReference type="eggNOG" id="KOG0028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061288_18_2_1"/>
    <dbReference type="OMA" id="YMDVDEL"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF59">
        <property type="entry name" value="EF-HAND SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="82"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="151" mass="17806" checksum="F507CF6D95F5B4E4" modified="2013-05-29" version="1">MEENSIEDYQLKKIKDKFDIFDKKHIEKIRTKDLPLIMQELDIKVNRNELNELKDILDHERTGWIEYEPFKEIMILKIKDKDPNLNIIKAFSLFDKDSKGKITLEDLRRVANDIGENVSDKELMEMIDEASPSGYVGIVEFENIMKRAGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNT2</accession>
    <name>M7NNT2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874723.1">
        <property type="nucleotide sequence ID" value="XM_007876532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNT2"/>
    <dbReference type="STRING" id="1069680.M7NNT2"/>
    <dbReference type="GeneID" id="19896390"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02699"/>
    <dbReference type="eggNOG" id="ENOG502S146">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1245830_0_0_1"/>
    <dbReference type="OrthoDB" id="6159137at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="46"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="222" mass="26636" checksum="0A337997035579E0" modified="2013-05-29" version="1">MIESSNSKVQGDEEKVDLEVNVEKTNTSGSLIRENMNDERIQNQGLNLFVTGIAERLKESELKEMFSVYGKVEKCQIMIDPHTKESRGFGFVQMSTIEGANAAREGLTGEERYGQVLSVDRARRNRPRTPTPGKYYGPPKKYYIQENRQLPPLLYHRYNRYNRYDYDRGMHDRFNFYYNERNFRINYAERYDGRYDDYYGYGRGYGRKKNEYFRRYYKNDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP03</accession>
    <name>M7NP03_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873063.1">
        <property type="nucleotide sequence ID" value="XM_007874872.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP03"/>
    <dbReference type="GeneID" id="19894846"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01149"/>
    <dbReference type="HOGENOM" id="CLU_2923677_0_0_1"/>
    <dbReference type="OrthoDB" id="10338489at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="61" mass="7354" checksum="B2CC441A44C81C3A" modified="2013-05-29" version="1">MDGYDRSSTFTTRKRYRDDWSYEESYKHIQYGTTEIQLNRMKKYILTLGDPVSILLEVKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP16</accession>
    <name>M7NP16_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02782</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09007.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613294.1">
        <property type="nucleotide sequence ID" value="XM_019757745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP16"/>
    <dbReference type="STRING" id="1069680.M7NP16"/>
    <dbReference type="GeneID" id="19896471"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02782"/>
    <dbReference type="HOGENOM" id="CLU_061288_2_0_1"/>
    <dbReference type="OMA" id="ARKMKEC"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000527">
        <property type="entry name" value="Calmodulin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="10"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="46"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="83"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR09007.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="171" mass="19269" checksum="27FE82EBA3B461D4" modified="2016-03-16" version="2">MNNEQNLTEEQISEFKEAFSLFDKDGDGSITTKELGIVMRSLGQNPTEAELQDMVNEVDADGNGTIDFPEFLAMMARKMKDTDSEEEIREAFKVFDKDGNGIISAAELRHVMTNLGEKLTDEEVDEMIREADVDGNVELLPFEYGIYLEKTNNTGDGVIDYSEFVKMMLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP74</accession>
    <name>M7NP74_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Proteasome assembly chaperone 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02688</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in 20S proteasome assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the 20S proteasome chaperone.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the PSMG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874712.1">
        <property type="nucleotide sequence ID" value="XM_007876521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP74"/>
    <dbReference type="STRING" id="1069680.M7NP74"/>
    <dbReference type="GeneID" id="19896379"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02688"/>
    <dbReference type="eggNOG" id="KOG3112">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062640_2_1_1"/>
    <dbReference type="OMA" id="PISWKGV"/>
    <dbReference type="OrthoDB" id="10260712at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="entry name" value="PAC-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016562">
        <property type="entry name" value="Proteasome_assmbl_chp_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12970">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12970:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010044">
        <property type="entry name" value="UCP010044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="246" mass="26864" checksum="90391416A3F73F70" modified="2013-05-29" version="1">MGEIESLVFSGTILIIPVVSIGNVPQLAVDLLVHSAGLSRKAMLDHSLLYPFAGSREDAGAPCCGGIATALDVFGDDKITVIQQRSPILPGEKKKFVEKVLLPFIKKGQFREVLVLGSTDASRRNDAEIKGPKEFILSTFQTISGLSEYFSTLKLISGSKKVFPKLFSSGALIPLLEHALCQNVSMTALVMYVMEGDNTEDAKRMARITAKACKLDDLSENLKSPKSWDYLFGKKLKIGFEGGMFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPC9</accession>
    <name>M7NPC9_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874469.1">
        <property type="nucleotide sequence ID" value="XM_007876278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPC9"/>
    <dbReference type="GeneID" id="19896153"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02460"/>
    <dbReference type="HOGENOM" id="CLU_2050621_0_0_1"/>
    <dbReference type="OrthoDB" id="5405779at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="120" mass="14025" checksum="9AE44CE1406D3F79" modified="2013-05-29" version="1">MVAPVIFIIFVPIFVAIIVLFFIHQLRTRKILEEDHDIDKSRFSVVQLYKSIFFCFRKKSPKKNIDRQDFEGSSLNDIIPDIYLPPIIFSSQDLNLFARTFHSDTNDTRYHTGVSVLSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPH6</accession>
    <name>M7NPH6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02776</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NOSIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874807.1">
        <property type="nucleotide sequence ID" value="XM_007876616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPH6"/>
    <dbReference type="STRING" id="1069680.M7NPH6"/>
    <dbReference type="GeneID" id="19896465"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02776"/>
    <dbReference type="eggNOG" id="KOG3039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053742_1_0_1"/>
    <dbReference type="OMA" id="PCVTKFM"/>
    <dbReference type="OrthoDB" id="116827at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016818">
        <property type="entry name" value="NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063">
        <property type="entry name" value="ENOS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063:SF10">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023577">
        <property type="entry name" value="ENOS_interacting"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="238"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="68"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR023577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="327" mass="37593" checksum="2FE97E1CFA61CEF5" modified="2013-05-29" version="1">MSRHSKRNTSLSFFTNYERSMLDYGTKKQRLESDSFRLFDACHLCLSQTRDTVSCEENGDIFCKVCIMENLLTQRKEIKKIEEEIEKKKRQNEIEEKRIEEIARMRTIKEFEVLQMGFNSRYNDDKHDDEVLQKKEVKDVFKLDKKELLMIAKNDRDREKLKYIKEQEAESKPKIGSFWIPSLTPSANNKDILKKQKRVPICPASSSDKPHKISLKSLISVNFTENKLSGGKELLRICPACKKKLSNISGAYIMKLCGHVICTICLDQFVRESGVCYVCESSLYVQNNGAMKNESKLLIVQLSNEGTGFSAKKDAIAKKVDVAFQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPI2</accession>
    <name>M7NPI2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aminodeoxychorismate synthase</fullName>
            <ecNumber evidence="4">2.6.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Para-aminobenzoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">p-aminobenzoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_02507</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11672"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58406"/>
            <dbReference type="EC" id="2.6.1.85"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4-aminobenzoate from chorismate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the anthranilate synthase component I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.85" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874517.1">
        <property type="nucleotide sequence ID" value="XM_007876326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPI2"/>
    <dbReference type="STRING" id="1069680.M7NPI2"/>
    <dbReference type="GeneID" id="19896199"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02507"/>
    <dbReference type="eggNOG" id="KOG1224">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006493_0_0_1"/>
    <dbReference type="OMA" id="DWSVNIR"/>
    <dbReference type="OrthoDB" id="64220at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046820">
        <property type="term" value="F:4-amino-4-deoxychorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008153">
        <property type="term" value="P:4-aminobenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010117">
        <property type="entry name" value="PabB_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01823">
        <property type="entry name" value="PabB-fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF18">
        <property type="entry name" value="AMINODEOXYCHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="12">
        <location>
            <begin position="320"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="11">
        <location>
            <begin position="501"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR09167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="767" mass="88688" checksum="47D22BB825D02A83" modified="2013-05-29" version="1">MNPECCLFVDKISAIDWEGKILLIDAYDSYFYNVCSLIETVLPSAELFIIRHDQFDSVTLYEYIDGFDCCILGPGPGNPGNKKDIGLFSVVWSLKEEHVLPVFGICLGMQTLCLEWGGSLSRLKYVAHGIISEIQHTQQDLFEGFPEIFKVVRYHSFCVNINKSTVLEALAWTEDQNGKILMGVKHKNKPFYGVQYHPESFLSEHGEKIIYNFWKIVCEFNKKERRPRIVLNKRWNNLHQTIEPLGTIIEWDKTKNQEFDQKFNQKFNKKSDKKFNKKLDRHNESIPIFEDANKHETVFFEVLNIKISAVQLVEELYLEKKELCAILESTSEPGRYSIIGVPSEGHYTLTHTFPDMHLIKTYSDRQEKIPLDRPHIWTWLINNIHKLHVNNSSEVPFQGGFIGYFNYEYTIYTSNIYEKSKFKHPDVNLLFFERSIVIDVIKNQVVIQSLIENDPWVTKTAAIIRSFNNKYSNNSAFSQNSFNQNNHFQNILQTRIVLPDKNQYLKKIKIAKNYIKQGESYELCLTSTTRIFSSKKYTPIDDWNLYKHLRTLNPAPFSGYLRLNGVTLLLSSPERFLSWSSSGLCELRPIKGTLRKDPSIDLKKATDLLKNPKDYAENLMILDLIRNDLCQIAKNVHIPALMQVEEYQTVYQLVSVIRGTVQPPYTGIDVLAHTLPPGSMTGAPKKRSIELLRELEKKERDIYSGVFGYFSVCGGGDWSVIIRSTFRYHDEDHWNIGAGGAITSLSNPQNEWDEMILKLQSVLSLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ43</accession>
    <name>M7NQ43_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1,4-alpha-glucan-branching enzyme</fullName>
            <ecNumber evidence="4">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glycogen-branching enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_00965</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Glycogen-branching enzyme participates in the glycogen biosynthetic process along with glycogenin and glycogen synthase. Generates alpha-1,6-glucosidic branches from alpha-1,4-linked glucose chains, to increase solubility of the glycogen polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872878.1">
        <property type="nucleotide sequence ID" value="XM_007874687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ43"/>
    <dbReference type="STRING" id="1069680.M7NQ43"/>
    <dbReference type="GeneID" id="19894663"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00965"/>
    <dbReference type="eggNOG" id="KOG0470">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011131_2_2_1"/>
    <dbReference type="OMA" id="YEMHLGS"/>
    <dbReference type="OrthoDB" id="196493at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11321">
        <property type="entry name" value="AmyAc_bac_euk_BE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02854">
        <property type="entry name" value="E_set_GBE_euk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000001">
        <property type="entry name" value="1,4-alpha-glucan branching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000250">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000003">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="12">
        <location>
            <begin position="152"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR10818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="670" mass="77959" checksum="22A563380194141D" modified="2013-05-29" version="1">MALEILHIDPYLKPYESILRRRYDISQKFLRHFEESEGLDMFTRSYERMGLNVQPNGDIIYREWAPNAIFASLVGDFNSWDTQLHPMSKNSYGVFEIIVPAVDGKAAILHGSRVKIFMITTKGERIYRIPAWIRRATQDLSVSSIYDGIFWNPSPYIFRNSRPPPPNALRIYEVHIGISTNESRIGTYSEFIQNVLPRIRYLGYNTLQLMAIMEHPYYASFGYQVTNFFSVSSRYGTPEELKELIDAAHGMGITVLLDIVHSHACKNVEDGINMFDGTDHLYFHGGKKGIHELWDSRLFNYGNYEVLRFLLSNLRFYMEEFCFDGFRFDGVTSIMYTHHGIGVSFSGNYDEYFGPDADDEGIVYLILANEILHRFYPSCITIAEDVSGMPGLCIPMSMGGIGFDYRLAMALPDMWIDLLKNKKDEDWDMGNICYTLTNRRYMEKSISYAESHDQSLVGDKTLAFWLMDKEMYTHMSHLCEMTPIIERGISLHKMIRLITHSLGGEGYLCFEGNEFGHPEWLDFPRAGNNNSFHYARRQWHLVDDDLLRYKCLNEFDRALQHLEEKYRWLNSPQAYISLKNEYDKVIVYERAGLLFIFNFHPYKSFPDYLIGVDVAGTYHIILYTDTKEFGGVKHINQTVHYKTNDFPWNNRKNSIKCYIPTRTAIVMALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ62</accession>
    <name>M7NQ62_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_02347</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874351.1">
        <property type="nucleotide sequence ID" value="XM_007876160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ62"/>
    <dbReference type="STRING" id="1069680.M7NQ62"/>
    <dbReference type="GeneID" id="19896040"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02347"/>
    <dbReference type="eggNOG" id="KOG2515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018152_0_0_1"/>
    <dbReference type="OMA" id="PRDMHAK"/>
    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF2">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE ALG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082549" description="Mannosyltransferase" evidence="11">
        <location>
            <begin position="28"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="268"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR09402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="567" mass="66936" checksum="706B8972522B1B94" modified="2013-05-29" version="1">MRDKISLRWALFSTLFLINLIPRFLAARYSIIHDCDEVYNYWEPLHYILHDYGFQTWEYSGEYCIRSWFYILLHSIIMIVPKSLGFKRITEFFFIRFVFAILCALSETKLCLSIIGVLGKDIGFFYFLFTITSVGMFNASTAFLPSTFTMYTSMLGLSAFFESALSKRTIEIIFWFFLGGIVGWPFSLILAIPIISYEFLISIYNIPLKQVFLKYLKAIFVCIIILAFVCLVDSLAYRKFQIVPLNIIKYNVLSGKGKGPEIFGVEPWWFYFLNLLLNFNVVFILCFLSLPIMFSYFSRFSLNIAKKGFLLSIISPFYLWFFIFTIQPHKEERFFFAIYPFICLNASIAISQSLSLIKSYNNFRYISCIVRYIYVFISTSVLVISFLRVLLIIDAYSAHMSVYTKIPSASNNFRSILCIGKEWHRFPSSFFVPDNISVKFIKSRFTGLLPGEFISNKDEWRSGMWLIPSNMNDLNMEEWEKYTDISQCDYLVDTDFFARYSFENSTEDIIEPRYVKNEEMWKKIFCMNFLDASSTRIYSRILWMPSKFSRRIYGDYCLLKRKKFHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ93</accession>
    <name>M7NQ93_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_02590</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874605.1">
        <property type="nucleotide sequence ID" value="XM_007876414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ93"/>
    <dbReference type="STRING" id="1069680.M7NQ93"/>
    <dbReference type="GeneID" id="19896282"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02590"/>
    <dbReference type="eggNOG" id="KOG1757">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062828_2_2_1"/>
    <dbReference type="OMA" id="MNKKGAP"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140898">
        <property type="term" value="P:CENP-A eviction from euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000021">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="20"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="12">
        <location>
            <begin position="102"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR09256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="137" mass="14583" checksum="EDEADD79EAB6C5A3" modified="2013-05-29" version="1">MSGKGKSHGGKGKSGGKSGEGRIQVSHSARAGLQFPVGRVRRFMKACTQNNVRVGATASVYIAAVLEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIRATIAGGGVLPHINKTLLQTPKNKKVSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ96</accession>
    <name>M7NQ96_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">valine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_02384</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09442.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874390.2">
        <property type="nucleotide sequence ID" value="XM_007876199.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ96"/>
    <dbReference type="STRING" id="1069680.M7NQ96"/>
    <dbReference type="GeneID" id="19896077"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02384"/>
    <dbReference type="eggNOG" id="KOG0432">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3860">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_247055_0_0_1"/>
    <dbReference type="OMA" id="PKYSCRQ"/>
    <dbReference type="OrthoDB" id="629407at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000020">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004349">
        <property type="entry name" value="PRK05729.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF109">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="39"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="689"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR09442.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="964" mass="112629" checksum="C0E471C8359DBF46" modified="2016-03-16" version="2">MVFLRRCKIRQIFFTKNYSHIPSHSLDGPYDPTLIEQDWYKWWQENGFFSPKHPFNECSSCNRVVTILPPPNITGILHLGHALTISIQDALIRWERMRGKSVIWIPGTDHAGIATQSIMEQFLMKTQKLKRKDMTRSMFEDIIWKWKGLNVAYIYNQIAFMGASLDWSKEFFTLDSSLSKVVTNCFIQLFNEGLIYRDMKMVNWSCSLETVISDIEVDHKVINKPTEIMIRGEPIEFGVLHKIAYPLVDPCNITEVVVSTSRVETIPGDRAISVNPNDIRFLNLHGKYCYHPLDPHIKIPIIPDEMVDPNFGTGAVKITPAHDPNDYMFSVRHKIPVVNVFDFDGRMNASCLLPELQHIDRLKCRKYILSKLKDKGLYRGSQNYQTSISFCSRSGDIIEYFLKSQWYLKTRSLASKVYDNMAGKFSVLPQHYSNKWIKWLENIEDWCISRQLWWGHRIPAWYVDCENGYWIAAESEQAALKISGGKDVKQDLDVLDTWFSSALLPLSVFRWDNKNIPIEYPLTFIESGSDLLFFWILRMALLCTHFTGKFPFNEIILHPLIRDSQGRKMSKSLGNIIDPLQIIKGVSLEISEDNAFNGNDLEQDMKHHLKTAKQQFSNGVKAMGTDSLRFSLIDYTKQTHQINMDIANVSSAKYIFSKLWNATKFFLCQIKYYNLKIIDENFKSEHIFDKYIISRLKETINLCNMGFELRRLFDVTKCLRRFIVYDLCSVYLEFIKQELKQNDNKRAECALSILYSTLYTVVKLLHPIAPFITEELYQKLLVFDPYSKISIMISNYPHKNGSFYLDYDSIKRIENIMMLVHEFRSMISNVGRLNYEHEGIIEINDRNKIFKEDVVKFKNIIRNMIGMKSLSLNDLNSGLLNVHSKFVNSELVLHLRVEKLCLNSFKQMNRIKWLQKQEEIISRRLKSEKYVQNASKCVQVKDIERLMDIQNELKLVRNLQKNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQF5</accession>
    <name>M7NQF5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TATA-binding protein interacting (TIP20) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01098</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873010.1">
        <property type="nucleotide sequence ID" value="XM_007874819.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NQF5"/>
    <dbReference type="GeneID" id="19894795"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01098"/>
    <dbReference type="eggNOG" id="KOG0915">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000880_2_1_1"/>
    <dbReference type="OMA" id="CRIKDIE"/>
    <dbReference type="OrthoDB" id="16066at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024372">
        <property type="entry name" value="Ecm29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055443">
        <property type="entry name" value="HEAT_ECM29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF19">
        <property type="entry name" value="PROTEASOME ADAPTER AND SCAFFOLD PROTEIN ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23731">
        <property type="entry name" value="ARM_ECM29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13001">
        <property type="entry name" value="ECM29_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24492">
        <property type="entry name" value="HEAT_ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome component Ecm29 N-terminal" evidence="5">
        <location>
            <begin position="9"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome adapter and scaffold protein ECM29 HEAT-repeat" evidence="6">
        <location>
            <begin position="1303"/>
            <end position="1464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1835" mass="213818" checksum="3644A032EC32DD21" modified="2013-05-29" version="1">MADKELKLLNKVEFHLGLANTDIELENTLKTYLCPTLLKLASPYESVRKKVLQICSHIRLRIKSNEDIKLPIDMLLEQFHSETVENFVKNFTLLFLEMAFFRSNEEKKKKMLSKLIPRLSTYFIEHKKKITYLIFHILEIYGDPHKVKICEFEDDQFLKSVFDAFSEDFAFLANVFKDLSLFSLSYFHSLSKKLSKEKIQELSSLNYLNNTNLSLDDANFSLQISILKKTCPGLSFNSFKFLTPKGLDTFNIDVLNRIKIGVIQFLSTSYFSLDQKFVTFIIFKFDADYNISSFAEACLKKLSIDLENEKIINRIYSLLIGNNNELETAKRNPVSAQIYIHLIYLLTKSYFAAKNVENMLKLLTYGLQNNVQKIVQATIAFVNWIARISPDDILKPIIQPILTLIINYIQNDEDKNEHLKEQLFTSFGLIARRETNYIDISVLKFLFDSLKRETKSVRFSIEQSLFLIMPCFQNIQEKFLEELNSLLFQIITSDHTDAHFSALRYCLAIFPFHESRARMLCLICLRENCIPKVKEEAKKGLNPYWFSVINQMKDIKQNPNTVFSENNYNFFSFPVFEDLIETLENQRLNGDGDNFFSHYFESLSPSIKNYMIKFIRQTLIMNLLQNDEHIQNFSPLNKTWEEQLDIAISDNEVFRTTYKKKIDIAWNNNTKFKKYLINYFQYVLKNFYETPLEFAYDVLELISLGPDDLTVMLTDKFDLFQTFLLFSNENLEYNIPHILGIVGSHFNISIEKITELLMFFTRSEISQTNRQFLSSHSSLLSLGYLLSRLKLRGRLTTVNIDLLYKCYSFIIEKVSSSNKLENISALVALGELCIFDTLSDFKSSNEEKFNFLIMTILDLYKKSKTDIKLREIITITLGKIATTMDPKQPEIDSILNCIFENYQTEYVYSYFIDGEALSCIAIGWKSKFLYKFVDMSISGIPETSRPEHMDFILKKILQEYIISSKPSLRKASIIWLLSLIRYCGESLSIQDNILIMQNAFILLLSDKDSFIQELASKGLKLLYEKCSEEVKSSLVHDLILCLTNKKKIKRTITSETELFDHEIHHENNTSISTYGDVCSLATELGNPELVYQFLNISLNSTIWQTRKGVAFSINEIISTNTKIDIIKNNPELFKKMISCLFLYKFHPISDVKKVMENVFSIFVNNSEKISEFNKDIMDRLLKGLGDQSWYIREASCNAIAHFLRTQTVENIEFYLEDIIIMSFRAVDDIKETVRLAASVLCRYITSFIIKNIDYRNNKKSNQSIILEKSIPILLKSVISDIQEVKGYALDTLIKICDTAKLSLKPFIPELIDNLLNFLTELEPQVMNYLELNTERFDITQEQLNDARVSLLRTSPILNAIESCIDQFDEEIARKTIPLLLNITQKAVGLPTKLACSKVIISIILRKNDCVSLYAKDVFRVFQECLFDRNHTVRISFSISLGYIARIALIEDLILLDSNLKKIYFEEKDEKKLITVASVYKHISIYANEKFVSLFYLFLPIVFLGKHDQFESVSFQFNEIWNENAGGSGFIALYLNKILNFIFLGLENNHWRLKMISAIALIEVIKFSKMDEYLDKLIPILMDILEGKLWDGKEVVLDAFITLLLYNENYLLDKAYLIQKIFNILVRETKRNNINYQRHVLCNFNRYVERYLTPESFENIYSVIEKNISNDSEKKEIYENNEISMPMGLVLREHSLNIIASAFHPKSDRTYACYVELVRIWRENIRLTWNIQTVICKSIQKIFKKNFLNTFLFDQLKNGNTLLDNWNIIYYALGNKKYESVRNEAVKAAKIFIESLKDCNDFELKSRILKDFNEFKSTEKSSMIKAELNHICFSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQG7</accession>
    <name>M7NQG7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCAAT-binding factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874080.1">
        <property type="nucleotide sequence ID" value="XM_007875889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQG7"/>
    <dbReference type="STRING" id="1069680.M7NQG7"/>
    <dbReference type="GeneID" id="19895794"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02100"/>
    <dbReference type="eggNOG" id="KOG2038">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003417_0_0_1"/>
    <dbReference type="OMA" id="NKLGHPN"/>
    <dbReference type="OrthoDB" id="28947at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040155">
        <property type="entry name" value="CEBPZ/Mak21-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048">
        <property type="entry name" value="CCAAT-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048:SF0">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="3">
        <location>
            <begin position="512"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="792"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="796"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="807"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR09512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="902" mass="105937" checksum="DCD393EE941A6B8D" modified="2013-05-29" version="1">MYKQDLDKDERLRQEKVFFSKKEVNKKNLNLMDQIISNEMQTGNKFNADKKRIKRHYLHKKNNISIMKDQNKVEKFKKKSKAEKILNKKVKKGYGFCEKEEDGVSKNNEKKNKQKDFIEKLETDLTVSTATDKEVFCYQKKLTFEPKIEWHLEELPIISSVKIGDSLAEKLYIQAKKYHEIEEEKYVRFSHKSSSNKHFFDNIMKFGTLSDRISALTLSIQESPLHSSKKMRMLLNMTKKKSRTESLQSVEALKDLFISTVLPNRKLKYFKQQESLGSKDVTKKHLILWAFEDFLKYYYFEYLQVIESLLKNSLSFLRERMVVCVFELIREKPEQEQNLLKLLVNKLGDPEKKVASKTSYCILKLTIVHPAMKEVIISEIEQFLFCPSTSRHAQYYAIITLNQMVLSKKTNIATYLINIYFLFFTKLTKLLQNENATKKVKSYKIPWKTKDILKKNKSDNDIYEKEINSKLVLAIISGINRAFPFSKIDDGVFESHVNSLFVIVHGINFNTSIQALILIFQISRFKQTILDRFYKTLYESIQDFRLFNSSKQIMYLNLLFKAIKADTDKTRVKSFVKRLIQYSNMHQITFICGIMILLNELEKIHPEIKSLYNRYEKVYNKKRNSLINILNGDKNVLSVKNNNVSILQDSLNKYDGYKRDPRYSNADNSYLWELIPFLNHFHPTISSFAKSLLYGYRISSKPNLSLFTLSHFLNKFVYKNPKTKIIFRGNSIMQPISKQNRNMFFLTKSDTFSHSPLNKESFVKQKIDQVSPDEIFYFRYFSQKQIINDRKKSTKAKVTSSDNESNVFEDSESIEDISDENLSEDTYDQSDIGDEGYDENDIDFNESENDLVDDEFIDKELSTISIGSKRKLNEKSNYVKGKKLKQLPVFASVNEYSAMLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQL1</accession>
    <name>M7NQL1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translation machinery-associated protein 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02144</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMA20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874124.1">
        <property type="nucleotide sequence ID" value="XM_007875933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQL1"/>
    <dbReference type="STRING" id="1069680.M7NQL1"/>
    <dbReference type="GeneID" id="19895837"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02144"/>
    <dbReference type="eggNOG" id="KOG2523">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090468_0_1_1"/>
    <dbReference type="OMA" id="GVENIHY"/>
    <dbReference type="OrthoDB" id="10249667at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11609">
        <property type="entry name" value="MCT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21155">
        <property type="entry name" value="PUA_MCTS-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016437">
        <property type="entry name" value="MCT-1/Tma20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048248">
        <property type="entry name" value="PUA_eIF2d-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798:SF0">
        <property type="entry name" value="MALIGNANT T-CELL-AMPLIFIED SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798">
        <property type="entry name" value="MCT-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26292">
        <property type="entry name" value="PUA_elF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005067">
        <property type="entry name" value="Tma_RNA-bind_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="92"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="180" mass="20299" checksum="C5A922E07C534BF9" modified="2013-05-29" version="1">MFKRFKGKEHIKGITQLKSSTQKALKAKIIEIYPDLEPFMSEIFPKKSQLTLIKCEERISLYSLNNEILFFQYFDNIYPHLKLLHKYPDGFLKVQADQGVIKSILSGANLMCPGLTSKGAYCPNNIDAEKTVSIMVYGKEHAVAVGLTKLSSSDIKTINKGIGIENIHYIGDSLWNLVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQL7</accession>
    <name>M7NQL7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit TIM54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_02148</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874129.1">
        <property type="nucleotide sequence ID" value="XM_007875938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQL7"/>
    <dbReference type="STRING" id="1069680.M7NQL7"/>
    <dbReference type="GeneID" id="19895841"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02148"/>
    <dbReference type="eggNOG" id="ENOG502QPMQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039097_0_0_1"/>
    <dbReference type="OrthoDB" id="5598305at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021056">
        <property type="entry name" value="Mt_import_IM_translocase_Tim54"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11711">
        <property type="entry name" value="Tim54"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR09562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="327" mass="37979" checksum="C48C2AA137CC5FE5" modified="2013-05-29" version="1">MNNLSRVISDFPWISRVKALKCPSKPWIVFFLSFFPFSGLIIYDKKEKKKIIEKYCNKVRFLSEKPMDPLELPRKVKIYMSLPPGNDIWMIQNHFQEYIRPILQAGAVDYEIIQGNKEGDLQRQVSEEILQYRRGESGLSPEMSKVMTNVRPSTEESSAIIIGRHSLKEYLAGVHDGWLEPLENSSSSLNSSKISVNILKKNVSSVLSKKDSQSHFPVDVTIPTLQFIPYPYVLGFLNMPVRIYRFLNRRFLAQSIASKTVNIILSNHTRLWTDDDQHLGEEECRGWPKQYRTRTTAGVWTDDFVLDKRIMNHVLVKNWFSILFSCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NR17</accession>
    <name>M7NR17_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Casein kinase II subunit beta</fullName>
            <shortName evidence="3">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02143</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874123.1">
        <property type="nucleotide sequence ID" value="XM_007875932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NR17"/>
    <dbReference type="STRING" id="1069680.M7NR17"/>
    <dbReference type="GeneID" id="19895836"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02143"/>
    <dbReference type="eggNOG" id="KOG3092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034027_3_2_1"/>
    <dbReference type="OMA" id="FGFSVYH"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000003">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000002">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF39">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR09556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="231" mass="27325" checksum="185D1893CC59A80F" modified="2013-05-29" version="1">MEDLLSKSYSDCSKYWIDWFLGIKGNEFFCEIDEEYIQDKFNLTGINTEVQHYNYAIEMVTDVFDHDVNDDLRNQIEKSAQHLYGLIHARFILTTRGLQKMLEKYKKYDFGRCPRVLCNSQAVLPVGLSDIPYSSSVKLYCPKCEDIYTPKSSRHVTIDGAYFGTTFPHIMLQVYPYLIPHKSQERYVPRIFGFKVREYSIIHQHQDIYKKEQDIKLDTIRENENSKNNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRT1</accession>
    <name>M7NRT1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cenp-O kinetochore centromere component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00475</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-O/MCM21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872359.1">
        <property type="nucleotide sequence ID" value="XM_007874168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRT1"/>
    <dbReference type="GeneID" id="19894173"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00475"/>
    <dbReference type="eggNOG" id="ENOG502SCC4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1175852_0_0_1"/>
    <dbReference type="OMA" id="HPENIGA"/>
    <dbReference type="OrthoDB" id="10050372at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031511">
        <property type="term" value="C:Mis6-Sim4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018464">
        <property type="entry name" value="CENP-O"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14582:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14582">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT MAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09496">
        <property type="entry name" value="CENP-O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR11458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="27950" checksum="4A13D4077FFDEF4D" modified="2013-05-29" version="1">MTSILAQYQTDISSLHEELKKLKSKRNDLLLKMLEERPVHEYTSAKAPQDLKPIESQWNIEKIYRLSGITFFIPSNPEKYFHLKKKLLYKLIGARIDIFHKGVFLEPHYLIFRVNTILSLYKHTIPNFINIDLLVKKWLNKDINIFLALIRKQLLYHTIRSSHIRELETIFSDFTILCDPSATLVQIKNQKYTINIKYGDTNIEKTIIINSKGDREIELEKKIFDNNLITIHHFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7NS43</accession>
    <name>M7NS43_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquinone biosynthesis O-methyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinol 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.64</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinone 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Polyprenyldihydroxybenzoate methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.114</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">COQ3</name>
        <name evidence="6" type="ORF">PNEG_01695</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine = a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="2.1.1.114"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="2.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinone + S-adenosyl-L-methionine = a ubiquinone + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:81215"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:19654"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:231825"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.64" evidence="5"/>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EC" id="2.1.1.114" evidence="5"/>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873658.1">
        <property type="nucleotide sequence ID" value="XM_007875467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NS43"/>
    <dbReference type="STRING" id="1069680.M7NS43"/>
    <dbReference type="GeneID" id="19895389"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01695"/>
    <dbReference type="eggNOG" id="KOG1270">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042432_1_0_1"/>
    <dbReference type="OMA" id="LASRWWD"/>
    <dbReference type="OrthoDB" id="3265906at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120537">
        <property type="term" value="F:3-demethylubiquinone 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00472">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01983">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="301" mass="35153" checksum="98A84AB30CF24040" modified="2013-05-29" version="1">MRKIKKKIQNPFKHLIKRYSSASFIETQHFDNLSEDWWNLQGRLKLLHKMNNVRIEYIKQCLMREEQKNSYNDEMTNDVFKRKFSTGKWLSNKCVLDVGCGGGILSELLSRLGALSVLGIDISSKAIEVAQMHRKKDPSLTNLIYQKTTAEALLNEKKQYDLITAMEIIEHVNHPKAFISTLFDLLKPGGFLILSTIEKTLLSFFLTIIIAERLFQLVPNSTHTWSKFIKRSEIKTWVSQYPDVSIIDCRGVIFLPWKNQWKIMDQNAIWAQQCNYFMAIQKKKNQGIIKKNYQKSKENQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSA9</accession>
    <name>M7NSA9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01431</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873371.1">
        <property type="nucleotide sequence ID" value="XM_007875180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSA9"/>
    <dbReference type="STRING" id="1069680.M7NSA9"/>
    <dbReference type="GeneID" id="19895128"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01431"/>
    <dbReference type="eggNOG" id="KOG0585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_484935_0_0_1"/>
    <dbReference type="OMA" id="WMSELIC"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902716">
        <property type="term" value="C:cell cortex of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051523">
        <property type="term" value="P:cell growth mode switching, monopolar to bipolar"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000206">
        <property type="entry name" value="Serine/threonine-protein kinase Ssp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF152">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE TOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="100"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR10157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="562" mass="64780" checksum="78607A9AE7CB4E5C" modified="2013-05-29" version="1">MNEHNMISYHHKERSLSSIFPSIFQKNTSDVIEECHKKPKKESSFFSLESLNSCMKKQYSSKVFNYSKWRETQNWQDVKETNHILKTTNLVSGRKVINKYEIIREIGRGVHGKVKLALDLSSNEYVALKIIERNSRKRLGRNETSSQEQKIRREIAILKKCIHPHVVRLREVMDDPMSRKIYLVLEYMDGGEVIWRTSDDKPALTIWQARSTFRDVVLGLEYLHYQGIIHRDIKPANLLWTKNHVVKISDFGVSYSNTCYGLSAEENELELAKTAGTPAFFAPELCYCDPSKRCTITKAIDIWALGITLYCLLFGSCPFTADGEYELMNVIPTKPLEIPSTPPIGDKAKNLLKRLLEKDPNARITLEEIKRHPWLLEDISDPENWIKETDPRNYQLLEVTQQEVDGAVSIVDKLKRKLTKLTSKFSRLAIITGLKKHNQNISSSKMQSERYKDVGKESSNQNFNNSNVKPSVCITKAKSVPTSAHMKKLIYEQYNNTNLSSSEPSITPYSETNMKFPKMTRSRAYSNLSAQTFPSFSKFENYNTYYIMDDNCLIEKCNVSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSG3</accession>
    <name>M7NSG3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peroxin/Ferlin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873783.1">
        <property type="nucleotide sequence ID" value="XM_007875592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSG3"/>
    <dbReference type="STRING" id="1069680.M7NSG3"/>
    <dbReference type="GeneID" id="19895506"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01812"/>
    <dbReference type="eggNOG" id="ENOG502S2MG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028361_0_0_1"/>
    <dbReference type="OMA" id="KDENNEC"/>
    <dbReference type="OrthoDB" id="72441at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051513">
        <property type="entry name" value="Tectonin_beta-prop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23250">
        <property type="entry name" value="DYSFERLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23250:SF1">
        <property type="entry name" value="TECTONIN BETA-PROPELLER REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="41128" checksum="DD885F6F8949422C" modified="2013-05-29" version="1">MIIKKKKSFLKIPKEQVLSNGNLHQIELKDQRYDYERIQEIIRPCGDNMQFKGLNKVDIVVFEYDKDENNECKNGKKNTVVDVLYENQRGISLCGTLIFSANSLFFFDPSPWTDKNFRYSPVNIFTATCPDPSWRWTWDKWRIDMYGNVDPDGWSYSFSFKSKRWYGTSIWFHSFVRRRKWVRQRQCCFDDPRSEDDGNYFTISSSYDPSRSLISTISPNKDVLSVSDNSEDDISVHDLLKRLRESRIDRERLHILKNFIIYNNKRIDSLKDLIKDILDCFIFQESRRQLLAFLIKMAKGVQTENYTLSDFSEETKKETNKDNIFELIDLIKKEIHKYEFWEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSU8</accession>
    <name>M7NSU8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1748-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873598.1">
        <property type="nucleotide sequence ID" value="XM_007875407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSU8"/>
    <dbReference type="STRING" id="1069680.M7NSU8"/>
    <dbReference type="GeneID" id="19897281"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03594"/>
    <dbReference type="eggNOG" id="ENOG502S6Z8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151392_1_0_1"/>
    <dbReference type="OMA" id="NKEVGKW"/>
    <dbReference type="OrthoDB" id="16824at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013726">
        <property type="entry name" value="Mitofissin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075:SF1">
        <property type="entry name" value="DUF1748-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08520">
        <property type="entry name" value="Mitofissin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082399" description="DUF1748-domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="8473" checksum="CA999E0D7F339227" modified="2013-05-29" version="1">MSFGKIVHISFDLILVSSVLAGIRRSTGLTIKTNMFDKDTEMFIDKYLSLGNWVMDQSIAFMTTSKYFERRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSV8</accession>
    <name>M7NSV8_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01469</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873408.1">
        <property type="nucleotide sequence ID" value="XM_007875217.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSV8"/>
    <dbReference type="STRING" id="1069680.M7NSV8"/>
    <dbReference type="GeneID" id="19895165"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01469"/>
    <dbReference type="eggNOG" id="ENOG502S43V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1321371_0_0_1"/>
    <dbReference type="OMA" id="ESALVFM"/>
    <dbReference type="OrthoDB" id="19714at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039924">
        <property type="entry name" value="ICln/Lot5/Saf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399">
        <property type="entry name" value="CHLORIDE CONDUCTANCE REGULATORY PROTEIN ICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399:SF0">
        <property type="entry name" value="METHYLOSOME SUBUNIT PICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03517">
        <property type="entry name" value="Voldacs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR10196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="208" mass="23822" checksum="01EEFDE91FB51349" modified="2013-05-29" version="1">MAFVYIREPPADLIELSEHQESTPRTFSSNVLYFLSKEAAFKAFPAIGLSEYIDAYITSQSFIIFSPSISKGLEIPYPKIVLHAIHRTPHNAFDTPCIYMQIEDLNNLALKENGMNGSVPESDTNMVELYISPTDSSTLRDFYTALSDCSSLHPCREQNLGEDINEFSQNHEWITETNNESETLQSFADRIHEREDKEENEAKWRCIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSZ3</accession>
    <name>M7NSZ3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873032.1">
        <property type="nucleotide sequence ID" value="XM_007874841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSZ3"/>
    <dbReference type="STRING" id="1069680.M7NSZ3"/>
    <dbReference type="GeneID" id="19894814"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01117"/>
    <dbReference type="eggNOG" id="KOG1110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042860_3_2_1"/>
    <dbReference type="OMA" id="PGGSYCM"/>
    <dbReference type="OrthoDB" id="899at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF115">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="2">
        <location>
            <begin position="21"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="118" mass="13120" checksum="C4B0D6B9856F2122" modified="2013-05-29" version="1">MTEHNFEMHLKSTLPPKDNPISLAYLSQCDGSNENFPIYVAIKGTVFDVTSNRASYGPGGGYHIFAGKDASRGLGKSSLKEEDAVADYSNLNESELETLEKWFDFFSKKYNIVGKVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7NT79</accession>
    <name>M7NT79_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial import protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873482.1">
        <property type="nucleotide sequence ID" value="XM_007875291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NT79"/>
    <dbReference type="STRING" id="1069680.M7NT79"/>
    <dbReference type="GeneID" id="19895232"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01537"/>
    <dbReference type="eggNOG" id="ENOG502SBHA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124524_0_0_1"/>
    <dbReference type="OrthoDB" id="5529571at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013262">
        <property type="entry name" value="OMP_MIM1/TOM13_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28241">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28241:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08219">
        <property type="entry name" value="TOM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="13924" checksum="C1C2213F9C83D4F1" modified="2013-05-29" version="1">MNENQLIHDSDIFSYELSEDNSASEGSEKDDVIDVLHVYPTHDDIENSLKKNNMSKLIPYVNSESYKKIWSLIRSSLINMFLPFINGVFLGFGEIFAHEISIRWNILGARQRPHRLNKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7NT98</accession>
    <name>M7NT98_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01557</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873506.1">
        <property type="nucleotide sequence ID" value="XM_007875315.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NT98"/>
    <dbReference type="STRING" id="1069680.M7NT98"/>
    <dbReference type="GeneID" id="19895252"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01557"/>
    <dbReference type="eggNOG" id="KOG0937">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026996_0_0_1"/>
    <dbReference type="OMA" id="KPLIWCD"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09250">
        <property type="entry name" value="AP-1_Mu1_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14835">
        <property type="entry name" value="AP1_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000006">
        <property type="entry name" value="AP-1 complex subunit mu-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="8">
        <location>
            <begin position="166"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="424" mass="49135" checksum="93E3C87E644997CC" modified="2013-05-29" version="1">MASSIYFLDLKGKILISRDYRGDIPLIYVERFLSLISESDDTIPATPCFTYDGVHHLYVRHNNLYILMLTRKNSNAAELLLFLHKIIEVFTEYFKVLEEESIRDNFVIIYELLDEMMDFGYPQITETKILQEYITQESHKLEVMTLPPIAITNPISWRSQGIKYRKNEIFLDVVESLNLLINSNGNIVMNEIVGVIKMKCYLSGMPELRLGLNDKVMFENTGRISRGKAVEIEDIKFHQCVQLSRFNNDRIISFIPPDGEFELMNYRMNTQVKPLIWIESMFENHSGSRIEIAIKLKSQFKRKSSSNNVEIIIPVPDDADSPRFCTSIGNVVYAPEKSAIIWKIKQLSGGQEYLMRAELGLPSVKRVEINTKKKPITVKFEIPYFTVSGIQVRYLKVVEPKLQYTALPWVRYITQNGDVNFRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTC3</accession>
    <name>M7NTC3_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873536.1">
        <property type="nucleotide sequence ID" value="XM_007875345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTC3"/>
    <dbReference type="STRING" id="1069680.M7NTC3"/>
    <dbReference type="GeneID" id="19895277"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01582"/>
    <dbReference type="eggNOG" id="ENOG502S178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067862_3_1_1"/>
    <dbReference type="OMA" id="DMLYRAH"/>
    <dbReference type="OrthoDB" id="2103474at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025187">
        <property type="entry name" value="DUF4112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519">
        <property type="entry name" value="MEMBRANE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519:SF2">
        <property type="entry name" value="PH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13430">
        <property type="entry name" value="DUF4112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="165" mass="19895" checksum="25474FD43D3E66BB" modified="2013-05-29" version="1">MNYTRIIKYVIRSKNLNSVFERLDPYDKEIKEYFAKYLEKNEKELGEFSKKELKILKKTRSYVYRLDYSAKCFCCEMRFGWSAIIGMIPVIGDIINLYLSMRIIKIYMKTEISKTIIIQMYINIFIAFSMGLIPIIGDMLFAYYKCNIRNYIMFEKTLKERKKIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTR0</accession>
    <name>M7NTR0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873126.1">
        <property type="nucleotide sequence ID" value="XM_007874935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTR0"/>
    <dbReference type="GeneID" id="19894905"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01208"/>
    <dbReference type="HOGENOM" id="CLU_299587_0_0_1"/>
    <dbReference type="OrthoDB" id="5368036at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1001" mass="117393" checksum="4619454A589B71BF" modified="2013-05-29" version="1">MSINLIVSRINSLCKEFGLNDKQYEIDEQDILQLDIVDEVYIKILKESVTKILALSSATITNFEKFTDVFHDLLKYFKKVESHSLDSSISFYDFVACSITRHYSHNVISKISLFSGTEFQKKRLANHIHNLLLCVYEVLNGIIRVILEMDKVFDRCYFNNIDNLNNCIINICTLVSQIILILFQTYFSRENSDILNTFLDIKNDSITYIKCIELMLFLYDNSYLKNNIRNIVKKAMLRCFDFKGFDIFLQILFKTKDSSDYDDIVKAVQQIYDGISKIIFRRSASIFKDQKFVVWGLLEYIELEKSGWTQIQYNLWLPPLFISSWLVPNERNDCEIIKYCYKLNNQISREIIDNIQFKIISSSPELSFQMSMSFIFSFQLDEVTSDQNFIIKRIITLLDNVRRSEIVEQMNLLMVSKYQCLHFFTWLWESSLKCPSNYILAFSDDLTLLWLLRRNFLLKYNSSIVSEFEHLVIFVLTGGKIDSDQKSPVYERGCCKDELDRSIIILKRQINFESWLLYLTAQDVKSMFVIVLTELLRLFKELCSLSILVPIQEKNIIEFVLFIFLDYDRQWIEFQCWNNLIYFLHSVSKEILMSVFTNETLTLNFNDNYIVKKDLYYNSMDNTSFSNSFETKTLKLFSRIMHLVSSLIREFEVLGTSIASGEYESVILNNLRKIIGINQFLIIILIYLPPDHLVNQYACSQYEFISLLSSSIIDVKYISWFQTTGKFLDHLLTIFVSTNLQLFAILSRQGIDNIDMPNNLKFSHFIEIMIYSSCRLDVIAGVILDLIKIYKNKWTTDSTDVICLAMTVIRSIRFFDKCETFLINKINDTILLFKQTNDSKIWEYVSSDIQNMEFLFYVLKEILHGYLCVECFAGISSENLSNDKKYPCKKCILIPNGLQLEFLHLAKLCIPQNAAWIVELKTHLLIAYLQKIYDIAFESKIEGYEVLYQVLKKIIPTLEIKKKPFICDDVKCDSQNEIVSSELFKLLELDHKEQILAIIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTZ0</accession>
    <name>M7NTZ0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872792.1">
        <property type="nucleotide sequence ID" value="XM_007874601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTZ0"/>
    <dbReference type="GeneID" id="19894579"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00881"/>
    <dbReference type="HOGENOM" id="CLU_2074157_0_0_1"/>
    <dbReference type="OrthoDB" id="3366546at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="13595" checksum="91E835271C9A6CC9" modified="2013-05-29" version="1">MPLKFLEKRTCNKDSISKSFNTSTKFHAETYLKKFGWKGYGHGLRDGSLVIPYQLPLIKKSIGYMDAWWIDLFNKKVASLNVGLSKHKNKSDKPKKSLLYTHFVLSKENNVLKKGSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUQ5</accession>
    <name>M7NUQ5_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872886.1">
        <property type="nucleotide sequence ID" value="XM_007874695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUQ5"/>
    <dbReference type="STRING" id="1069680.M7NUQ5"/>
    <dbReference type="GeneID" id="19894670"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00972"/>
    <dbReference type="eggNOG" id="ENOG502QTWB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1475743_0_0_1"/>
    <dbReference type="OMA" id="WIAISCF"/>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021100">
        <property type="entry name" value="N-glycosylation_EOS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28147">
        <property type="entry name" value="N-GLYCOSYLATION PROTEIN EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28147:SF1">
        <property type="entry name" value="N-GLYCOSYLATION PROTEIN EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12326">
        <property type="entry name" value="EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02070">
        <property type="entry name" value="NGLYCOSEOS1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="183" mass="21379" checksum="60250267FC075DA5" modified="2013-05-29" version="1">MMLHQDDLIEDIPLRICHILSILPACYWAIHFVFGKTQVKRILYVHIEYAWEIWMASIWFIVCAFLFYKLTSGLLLRWHMKYSYPAILIRLMSLNLMNGCLTRLFVSFSSNKIQQLFCAILMTCILACIYIIQNYVTSNFSQLGITKAPKRLNLINIAIYVMVPIGFASFITMLCALFHIKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUS5</accession>
    <name>M7NUS5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_00997</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872911.1">
        <property type="nucleotide sequence ID" value="XM_007874720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUS5"/>
    <dbReference type="STRING" id="1069680.M7NUS5"/>
    <dbReference type="GeneID" id="19894695"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00997"/>
    <dbReference type="eggNOG" id="KOG4839">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_371348_0_0_1"/>
    <dbReference type="OMA" id="CKYETTG"/>
    <dbReference type="OrthoDB" id="1922977at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019607">
        <property type="entry name" value="Putative_zinc-finger_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10650">
        <property type="entry name" value="zf-C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="652"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="652"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="378"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR10851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="749" mass="85189" checksum="B6F7E232CAF98A5B" modified="2013-05-29" version="1">MKLDELSLSSLLNEKKGDFEGLDEISKDSNGSSESFGNQQDRNEKEEGEISDNSVSDKSCGFVSGGGKTFLKKKGFLNRIPYRKNYRMRSNPILYPHLYQSIFLQNNSNLKLEGKLALEFLSSQGISFEYLVHLGINRDFLCKIFLEAGLSLPETENIQSKNVVKEKRDMGVGLKDDKELTKISSLKPQKADIVDHIKGFSDTSVSQKSSNKNLGQHVDSDTFLQNIRNSIKNKIQISENIQKNVSISHKRKHVSTLDSKNEDSFTPRKKFGSESLASVVIELSDDDNDENSGDNNNNCDNISKIKKPLESENIKNDAITKLKQKEEEIKRMMEIIAKLESSKKMKKKPIEDANHIPGFNATNINEENSIIFNTNQERKEASKDSEDKSNEIALHEKEQVLQEKLHKINMQLFQEELLIQKLKNELAEAESLFQKSFQIKSDIQIQLKDFRKSHDSIDKVKGDSKVSSIKNLENSHSISENLITVADSKNEIFISSNNISLSNQNNHEKVESVDFSDDNDKIKTFKKASGTQKKAVTTCFVHEEISSSKNDEISSKIKNHDKLFASTNMDELSETFKHDKNDLSESILTSHSQKNVIISLQSKDVIANKGCFVFYKEYSSPLRIFHAFRYHPHFLSWVKGGFLSRTYSTRSDPNKKVCVFETAGGVCNDDSCKFLHFKEIGQTDDQFLVEMSSFPVGETEEERQSYFSGLRALIQTLRASYPHDTIKIAQSIIDYRKQFLNDSSRVILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUZ2</accession>
    <name>M7NUZ2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01081</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872993.1">
        <property type="nucleotide sequence ID" value="XM_007874802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUZ2"/>
    <dbReference type="STRING" id="1069680.M7NUZ2"/>
    <dbReference type="GeneID" id="19894778"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01081"/>
    <dbReference type="eggNOG" id="KOG2177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_719857_0_0_1"/>
    <dbReference type="OMA" id="ICEICVG"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042755">
        <property type="entry name" value="COP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44080">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44080:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="17"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="384" mass="44652" checksum="0D188BC2E6D85113" modified="2013-05-29" version="1">MEELELDIAKLKRSLICEICVGLFGSPFMLSCGHVFCYGCILDWLFHKRTCPTCRHPLSQSPSFAYLVQEMVDVFVHRMEASDPEGEGKHVKKHQEDQRKRMEENRDNLFFDLFVETKFTSVLCDREDGVMRCMRCYWEIEGTVCAHCGFQFSDEEVSSLNDFSYSDLHVASELHDQDSLYQDSICSEPDDYDYDDPFIDDRPTDEIERDLSIEEINDSKDLLEQSFSTLYSDTAEDKGFDEISYDSLIEKHERRSKKSKKRGKNVSLGTQRSISQLILLDSDENVNIHENSSTLSNSRSDLVSFPEKRNEKLRYIDLSSNSSKYQETYPSNSNHDIINEYLSDDFSISSLQKYQFPRKQCSKTRNRCRIINIPSSVNDSDYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NV23</accession>
    <name>M7NV23_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00743</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872644.1">
        <property type="nucleotide sequence ID" value="XM_007874453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NV23"/>
    <dbReference type="STRING" id="1069680.M7NV23"/>
    <dbReference type="GeneID" id="19894441"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00743"/>
    <dbReference type="eggNOG" id="KOG0531">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_291889_0_0_1"/>
    <dbReference type="OMA" id="QPMIHLR"/>
    <dbReference type="OrthoDB" id="7451790at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061499">
        <property type="term" value="C:outer plaque of mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031028">
        <property type="term" value="P:septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052574">
        <property type="entry name" value="CDIRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566:SF1">
        <property type="entry name" value="PROTEIN NUD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR11147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1108" mass="126778" checksum="7479900B94789F54" modified="2013-05-29" version="1">MANAPVLESNNTFFNVERGDESIEWVTPSSGGTLPTVQSLNYEDTVRILTERDPSLIVNEMLPEWKKENANMMKDMFNDILSAKSSVNKIDENFKSSCKKEEERGSVFEFWDIKNLNKKNYKTVNFSSKDSSDSLHKLNAFTCKNKESVGLKVDNSVLASNVFENDLKSFQKESQDRETNNQFAFNCNLEDKKNEIESSIYENNKSKNMMPVTKSPLKLFHDNFDTFTNNKLAAAVFELANQETDEDAKTSSSGPERKRARICHERTNSITTQNFFNEAQEVMERIRNRRNPVEKSILESVREEEIAYDSKNTALNVQKERDPSLKSKRSSMNSCAAVTNETPTRSMFSDWSSEHTSSKNTLISLSDSVKCHKEMEDLNTMESTKHQQGEKEEALNYAKQTWGKEPTIFQKTKISKPTSFVNKESNANRLNHKLFSSENLKVITPQDVSQFLSDKIGSMTLDKTKNTWVQDYHDKTEDVFEGIQDFPVSPESLDEIHKKDPNIFKDDAQNINEKPKVSFTKEIYIKKLEDKMKESLKKKVDKNIPETSTYPKNINFNQESVEDSSNEIIADDNLIGVNLDSEVAENHSSKSFMKGIKPVLQPSIDEKSLINENSVDIYKDLSDSKFLGDHPDLSSTTLNCSFSMAIQNLVVVLTDIEPYEPFWEKFQHLNLSNKNIESLIGLSDFCPKLNNLDVSYNKLTFLTGCPKTIRNMNLQNNNLSSLTGFSHLINIQYLNLSNNQIQSLKGLNVLVHLRQLDVSNNKISSLDGIEKLDGLLDLSLSHNLLCDIDLSDCDLPKLEQLNLCCNKIKRFKGVDNLQNLTILNLDKNSLSSFYAEKKMLRLRVLKLSKNFLKKFDPKNFPNLRILSLDNNSLQDINEIRSLGKLEKLSIRNQKLSKLNLELNSLMNIKKICISLNPICSLNFSSRLLTLQYLELVNVQMTALPQSFAEMALNIRMLNLSHNHLKDIGPLKGMPLLKRLFINGNQISKITDVIEVLSSLKALRDFDMRLNPCVINLYPPFFSLDPNNSSIFFGLQMKLYDNTWVEKDKEFVKTLPKKIQLRRKLYQDLILSSCPPLKWLNGKNITEIHIKNAIKFVSYISFDTNSKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NV51</accession>
    <name>M7NV51_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anaphase-promoting complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00607</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the APC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872504.1">
        <property type="nucleotide sequence ID" value="XM_007874313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NV51"/>
    <dbReference type="STRING" id="1069680.M7NV51"/>
    <dbReference type="GeneID" id="19894305"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00607"/>
    <dbReference type="eggNOG" id="KOG3437">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039415_3_0_1"/>
    <dbReference type="OMA" id="FITIEFP"/>
    <dbReference type="OrthoDB" id="24948at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08366">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000122">
        <property type="entry name" value="Anaphase-promoting complex subunit 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016901">
        <property type="entry name" value="APC10/Doc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028841">
        <property type="entry name" value="APC10_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 6" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DOC" evidence="7">
        <location>
            <begin position="12"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR028841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR11006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="198" mass="22559" checksum="C8FD0CEA3480F718" modified="2013-05-29" version="1">MDLEMPDMQDFEGNNEIDSVLDLDSDIENKNDKREIGNLATWTVSSSKPGFGVEQLRNDNVDTFWQSDGPQPHYINIHFIKKVSIKLLSFYTQYRQDESYTPSKISVRAGTGFHDLQEVIALDLNEPSGWVHISLGDCGKDGLLRTHLLQLCVQANHQNGKDTHIRLVKVFAPRIYAADETDILPYTSIIFSKHLKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVB9</accession>
    <name>M7NVB9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL15/eL18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00821</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 33 different proteins. The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and at least 46 different proteins. eL18 interacts with NAP1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872728.1">
        <property type="nucleotide sequence ID" value="XM_007874537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVB9"/>
    <dbReference type="STRING" id="1069680.M7NVB9"/>
    <dbReference type="GeneID" id="19894519"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00821"/>
    <dbReference type="eggNOG" id="KOG1714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080024_0_1_1"/>
    <dbReference type="OMA" id="IDICHKN"/>
    <dbReference type="OrthoDB" id="6353017at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021132">
        <property type="entry name" value="Ribosomal_eL18/eL18-A/B/_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01106">
        <property type="entry name" value="RIBOSOMAL_L18E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="2"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00062522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR11232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="186" mass="21095" checksum="F1159EE487E7CE38" modified="2013-05-29" version="1">MGVDKVSRSIKKKSRTAPKSENIYIKLLVRLYRFLARRTGSSFNRTILKRLFQSRVNRPPLSISRIIRALKGIECTDSKIVVVVGTVTDDNRTLEIPKLSIAALRVTASARARILKSGGEILTLDQLAIRVPLGNNVILLRGKKNTREAVKHFGMGPHKHKKPYVRSKGRKFERARGRRRSRGFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVE9</accession>
    <name>M7NVE9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">E3 ubiquitin protein ligase</fullName>
            <ecNumber evidence="15">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PNEG_00713</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the BRE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="15"/>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872613.1">
        <property type="nucleotide sequence ID" value="XM_007874422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVE9"/>
    <dbReference type="STRING" id="1069680.M7NVE9"/>
    <dbReference type="GeneID" id="19894411"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00713"/>
    <dbReference type="eggNOG" id="KOG0978">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019713_2_0_1"/>
    <dbReference type="OMA" id="YRQMQEY"/>
    <dbReference type="OrthoDB" id="654191at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033503">
        <property type="term" value="C:HULC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16499">
        <property type="entry name" value="RING-HC_Bre1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058643">
        <property type="entry name" value="BRE1-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013956">
        <property type="entry name" value="E3_ubiquit_lig_Bre1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163">
        <property type="entry name" value="RING FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08647">
        <property type="entry name" value="BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26095">
        <property type="entry name" value="CC_Bre1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11 15 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="646"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="21"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="169"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="317"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="565"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMR11116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="698" mass="81709" checksum="D62BECFEE790E7A0" modified="2013-05-29" version="1">MEDKKRQKDMVEILSYEPPLKKQVFENVLGVEEEVEDFQKEAIWRRMQEYKREAIRAKERVEELEKRIKYQDEHLVTIDAWFDEFLNEIYIYSGAKGTLEAGIMNEGNFPGLLFESDTKFKCHLSEKKSKIMNIAGSILNMVKSSCIEDTEIERIKNYAAKLSSDLTIARSYIEQLKLERENNEKKMEEMFYEIMSLEKKIDREKSMTLSKMKLNAMKKPQEEGSNIKLVEVTKTSKLEENKSNENIEAIEIKLKEMNVINEKRLSEISKLNNQNSKLREQLLNLELKLKNPSEEEIINSDLYYSLKSKYELCAAKIKEIEPAYESLNKEVEKLRLERLEFKEELLNEQRNIITDMRDQLSKVEQDLARVRTVRDELLSQLNIKKATEFENSTAKKELLELLETRNTRITALEEQLQRLNNQIKQDCELGNDVNLEKSKEELLKQIERLEKQNKSLSSELLALEQAFNKAHHQSSLKVNEIIAKEDKFYRLNADKAKADQKYFDAMKAKDKLTIENKTLKQQNSKAGDIIIKLQEAEKITMQKLIILEKQIAILRPANETLISKVHELQLKIEEKDHNIKNIGQQISMLKQRLIEQENITSTEIDSKRIAEEKIEKLKIQIQRNKNQNTVNGDIDELKIYKSMAKCSVCETKWKNTAISLCGHIFCKECINKRIETRQRRCPSCNRGFGSGDILQVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVG2</accession>
    <name>M7NVG2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation machinery-associated protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872628.1">
        <property type="nucleotide sequence ID" value="XM_007874437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVG2"/>
    <dbReference type="STRING" id="1069680.M7NVG2"/>
    <dbReference type="GeneID" id="19894425"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00727"/>
    <dbReference type="HOGENOM" id="CLU_184661_2_1_1"/>
    <dbReference type="OMA" id="HDLEFQE"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015157">
        <property type="entry name" value="TMA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28632">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09072">
        <property type="entry name" value="TMA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="52" mass="6107" checksum="DE55F8151947447E" modified="2013-05-29" version="1">MSGRQGGKLKPLKEPKKKKKELDEEDLAFKKKQNDNLKKEQEARKLLLSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M7NW46</accession>
    <name>M7NW46_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIX23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872248.1">
        <property type="nucleotide sequence ID" value="XM_007874057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NW46"/>
    <dbReference type="STRING" id="1069680.M7NW46"/>
    <dbReference type="GeneID" id="19894073"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00375"/>
    <dbReference type="eggNOG" id="KOG4613">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081050_1_0_1"/>
    <dbReference type="OMA" id="AKWESPG"/>
    <dbReference type="OrthoDB" id="5593818at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019171">
        <property type="entry name" value="MIX23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905:SF2">
        <property type="entry name" value="PROTEIN MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09774">
        <property type="entry name" value="MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="192" mass="22473" checksum="B188972127E439AE" modified="2013-05-29" version="1">MEKSTFPLNPSICFDISYIKNFLRFSRAQLDDTITFHLNSLSIEKPFISESLKTKPLQLDVNLQPDTKTCLSFIHQVFNVWETRSSLISYCQSVAVKMEDSSTSNTSFISSSVDTRKDPYSGRTCIHETKQRMLQNILNMEERVEHVVRNHSWERIVRRCGFLQLPETYQTAMDNWHEKYIKDKPLDTSHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWG0</accession>
    <name>M7NWG0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872387.1">
        <property type="nucleotide sequence ID" value="XM_007874196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWG0"/>
    <dbReference type="STRING" id="1069680.M7NWG0"/>
    <dbReference type="GeneID" id="19894198"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00500"/>
    <dbReference type="eggNOG" id="KOG0882">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_31_2_1"/>
    <dbReference type="OMA" id="GMVEYWR"/>
    <dbReference type="OrthoDB" id="10264753at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000003">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD repeat-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000450">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD-repeat protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="105"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="9">
        <location>
            <begin position="472"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="623" mass="70581" checksum="C2365A7B048701B4" modified="2013-05-29" version="1">MATDSYVSPNNILEDQISNAENDVGPAPIIIHTSLGKRKRAMDYQEKYLSTLPESKKYTKSFMHRDNIHSICVSSKYDFIITTSIDGHLKFWKKQISGIEFVKHYKAHLGPVISTSVSTDGSLFSSVSSDKSLKIFDIANFDMINEITLGYTPLTLCWVYSKKHAIAFLAVSDSSSSIINIYDGKGDSSCIYVINSLHTKPVSIISFNSVYNCAISVDESGMIEYWEPDSQYKKPKNIFEFKSDTDLYEFKRLKSMPTSITISPDGQKFSTISFPDQQIIIFNFKTGKIIRKYDESLDMFNKLQQSDKNIYKLDDIEFGRRVSIERELINDKFYRSTLNTVFDESSNFIIYPTLLGIKFVNIYTNCCVRLIGKDESLRFINLSLYQGAPRKTKRTTLAMIASENPLVAESKNIDPILFCSAYKKPRFFMFTKSYESDLTSERDIFNEKPIKGDNVSTEMRLSTSTGTSAVIHTTLGDICIRLFPEIAPKAVENFVTHSKNGYYDNTIFHRIIKKFMIQCGDPLGDGTGGKSIWGVEFEDEISLELKHDHPYTVSMANAGPNTNGSQFFITTECTPWLDSKHTIFGRAYSGLDVVHAIESIKVDRHNRPTPIDTAPKILNITVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWK2</accession>
    <name>M7NWK2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase II subunit RPB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00542</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872432.1">
        <property type="nucleotide sequence ID" value="XM_007874241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWK2"/>
    <dbReference type="STRING" id="1069680.M7NWK2"/>
    <dbReference type="GeneID" id="19894240"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00542"/>
    <dbReference type="eggNOG" id="KOG1522">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038421_1_1_1"/>
    <dbReference type="OMA" id="FYFEVES"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07031">
        <property type="entry name" value="RNAP_II_RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="8">
        <location>
            <begin position="18"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="295" mass="33253" checksum="AD089C4F1C73FBA2" modified="2013-05-29" version="1">MDTREGPQITIRSLGKHSVDFVLSNVDLAFANSLRRIILAEVPTIAIDLVEIEMNTSVLADEFITHRLGMIPLHSSNVDDKLVYTRDCDCDQYCRKCSVQLTLYAKCTGDGTMDVYSRDLVVENNATIGTPVIDDPEGKGILICKLRKAQELKLKCIAKKGIAKEHAKWSPVSAIAFEYDPWNKLRHTDYWFEESSEAEWPKSRNTDWEEAPRDKTFDYTAEPNKFYFGVETVGSLPPNEVISQGIKYLQVKLATIVRDLQRGGVENMGIGAVGFGDDIHLSNKTLNGWEKTTWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWV9</accession>
    <name>M7NWV9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein bL21m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871941.1">
        <property type="nucleotide sequence ID" value="XM_007873750.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWV9"/>
    <dbReference type="STRING" id="1069680.M7NWV9"/>
    <dbReference type="GeneID" id="19893782"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00084"/>
    <dbReference type="eggNOG" id="KOG0453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1454991_0_0_1"/>
    <dbReference type="OMA" id="ITIHDIH"/>
    <dbReference type="OrthoDB" id="5994at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="bL21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="bL21-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="L21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR11646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="186" mass="21790" checksum="6052F4B7E515C71D" modified="2013-05-29" version="1">MKKWNIFSSSRRCLLLFFRKNGVFIERKLFFSKNKGLLPPFFARFISLSPKIKSSVESTSLITTPFKKFLSEPSFYAVIHIYGRSFIVTEGDVVTLPQRLCDVKPGDIIRLNSISKLGSRNYTLKGQPYIDEKLYTCRARVLELTKAPMSYFIKKKRRQRRIKVVKSKQDYTVLRICEITIHDIHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWW7</accession>
    <name>M7NWW7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_00194</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872057.1">
        <property type="nucleotide sequence ID" value="XM_007873866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWW7"/>
    <dbReference type="STRING" id="1069680.M7NWW7"/>
    <dbReference type="GeneID" id="19893892"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00194"/>
    <dbReference type="eggNOG" id="KOG0475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003181_2_2_1"/>
    <dbReference type="OMA" id="CLDWTPW"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000011">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF6">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="568"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="711"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR11762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="763" mass="86989" checksum="3757F665663BF5D9" modified="2013-05-29" version="1">MYSRKFLENPELDQEFKKSVNNVNEKKKGDLLIIEDEEKDDFLKEPEDIYTDKSFFLKKNKQNEDISLTPSTNKISLESLKKKESEYNVNDFYTIDWVDENTKERYRKEKLRELKGIRGKAIRFWEFNQVWFIIVATGISIGVISGFIDIVSGWLSDIREGYCKSGFYLNHIFCCWIPDDEKTCSDWISWGDLISSSRRKSYIISYIFYVIIVTLFGGISSFLVINYAHYAKESGISEIKTILSGFVMHNFFGKWILLIKSLSVCFSIASGLWIGKEGPLIHIACCFADLFFKIFSTSKENQAKRREILSAAAAAGTSVAFGAPIGGVLFTLEQLSYYFPDKTMWKSFVCAMIGAMSLKFVNPFRDGRLVIYQAFFKIEWYSFELIPISLLGIIGGLYGHAFIKLNEKILKFKYKYQISRFPIQEVLIVVFITGLVNYSNIFMKSHHYKLLAKLFQKCNENDALGFCLTDNILSSALMLLLATIFGTFLCVITFGLQVPSGIILPSMVIGALYGRLIGIIIQYIQHKVPSARIFSACKPGVECVAPEIYSIIGAVSALAGVTRMTVSLVIIMFELTGALTYLLPIIIAVVISKWVGDAFGKYGIYENWIYINNYPYLSKELDIKHDTIENYITKTNNLVTITAKGHTIKTLELLLKNYAYRGFPVINNSNDAILIGYISQKFNNYFKNSYCYFTDTQFLDPSTYINLGPWMNKSPFTLSPKSTIHLTTNLFQKLGIRLILFTTNGQLQGLITKKDLIKRIFNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWY8</accession>
    <name>M7NWY8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCA7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872087.1">
        <property type="nucleotide sequence ID" value="XM_007873896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWY8"/>
    <dbReference type="STRING" id="1069680.M7NWY8"/>
    <dbReference type="GeneID" id="19893916"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00218"/>
    <dbReference type="eggNOG" id="KOG4140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044734_0_0_1"/>
    <dbReference type="OrthoDB" id="21678at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904802">
        <property type="term" value="P:RITS complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013243">
        <property type="entry name" value="SCA7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037804">
        <property type="entry name" value="SGF73"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805:SF1">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08313">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51505">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCA7" evidence="2">
        <location>
            <begin position="196"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR11792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="360" mass="41108" checksum="3A99C9210EE408D9" modified="2013-05-29" version="1">MEDKETDGLWSPVISLLFCEKSLSLFNEKEKERCVKLDDKNKKLEIEDAGWITVAEELDRKEPLILPERLNKPGSPITTMLDLDDFEKYGYNPLSETMKYIHCKNCGRVVLQNVFYKHAKLCNQLQDDPSSTSREAFEKTMIELQNVSMKRSKKRHHSDGDSDTSTVNDTNKASKAGKYDYKDKNELKKLKSKNILIKQKVSIDLEKQCGVLLPNGNLCSRSLTCKSHSMSAKRSVPGRSRPYDILLVHYQKKNKIKQQKAATMASSVFEDYTSDARQVDSDEEVTLVMESILCSAACPLERKVMVPVRRKRRSFRFQEMLSVALCQGQWPGKIQGSVSGILGRVIPFHVNSDWKTDENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7P2B5</accession>
    <name>M7P2B5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I and III subunit RPAC2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_03469</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875557.1">
        <property type="nucleotide sequence ID" value="XM_007877366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P2B5"/>
    <dbReference type="STRING" id="1069680.M7P2B5"/>
    <dbReference type="GeneID" id="19897156"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03469"/>
    <dbReference type="eggNOG" id="KOG3438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090381_3_0_1"/>
    <dbReference type="OMA" id="MRIQMYD"/>
    <dbReference type="OrthoDB" id="510325at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07029">
        <property type="entry name" value="RNAP_I_III_AC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerases I and III subunit RPAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033898">
        <property type="entry name" value="RNAP_AC19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF28">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="7">
        <location>
            <begin position="31"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="121" mass="14047" checksum="52FD60216260C423" modified="2013-05-29" version="1">MDLEKSTILFPHEIKKKIYILPDASNDLTSVTFQIIKEDHTLANALRYIIMKNPDVEFCGYSIPHPSEPKLNFRIQTYRKVSAVDVFLKGLDDLIALCDHVADTFQKEIRFSNSKEYKRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7P2Q2</accession>
    <name>M7P2Q2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Centromere protein H C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_03335</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CENP-H/MCM16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875413.1">
        <property type="nucleotide sequence ID" value="XM_007877222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P2Q2"/>
    <dbReference type="GeneID" id="19897022"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03335"/>
    <dbReference type="HOGENOM" id="CLU_1078294_0_0_1"/>
    <dbReference type="OMA" id="VEWANDE"/>
    <dbReference type="OrthoDB" id="2274804at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043515">
        <property type="term" value="F:kinetochore binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040034">
        <property type="entry name" value="CENP-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008426">
        <property type="entry name" value="CENP-H_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48122">
        <property type="entry name" value="CENTROMERE PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48122:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05837">
        <property type="entry name" value="CENP-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centromere protein H C-terminal" evidence="8">
        <location>
            <begin position="42"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="251" mass="29442" checksum="1E043716007F4CBF" modified="2013-05-29" version="1">MNSLKELSSFCELLILNITEDRNQFHRLKLCPSEVFNEKERNVLLLYKKLEELRNKRKMLLFEEEISVDNNILDQELSEKIKEAEFELLIANATNTTKDLIIENFIETNPILQAAYSTQDSTKQDKIIGLCLENCDNIISNLLNLHNILLKNEKKIVPLQKEVLNLFLKNKEKVNKIMEIITNIKDREEKILSVLEKQQKEKLIKEMNDIKNRAIIVKNCLQGIILESGIDWYGNEHWRNIMLKAGEVDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7P2W7</accession>
    <name>M7P2W7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">2-oxoglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.2.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">2-oxoglutarate dehydrogenase complex component E1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PNEG_03370</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoglutarate + H(+) = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:20092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="5"/>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875453.1">
        <property type="nucleotide sequence ID" value="XM_007877262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P2W7"/>
    <dbReference type="STRING" id="1069680.M7P2W7"/>
    <dbReference type="GeneID" id="19897057"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03370"/>
    <dbReference type="eggNOG" id="KOG0450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004709_1_1_1"/>
    <dbReference type="OMA" id="RDSYCRT"/>
    <dbReference type="OrthoDB" id="413077at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1150:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11610:FF:000009">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12470:FF:000003">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase, E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008907">
        <property type="entry name" value="PRK12270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="17">
        <location>
            <begin position="655"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMR08200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1025" mass="117816" checksum="8C82E375F97FFF1C" modified="2013-05-29" version="1">MGRNIYFFQKKILNITKNPFFTKKKDTWKCINTAGRSIKRIHSIAFLKKAPEWSDSFLHGTSANYIDAMYEVWKKNPEDVHVSWQIYFKNMSNKNIKPIYAFQPPTTIIPASIGEIPTLPTGMDDSASIIQHLKVQLLVRAYQVRGHLCADIDPLGIKAKDDLIKEIPKELTLEYYGFTEKDLNTEFNLGPGILPAFSTKEESKMTLFSIVENLKRLYSGSYGVEYVHIPDRYQCNWLRERLEIPIPYQYNNEEKQRILDRLIWSDSFEKFLATKYPNDKRFGLEGCESLIPGMKALIDHSVDLGIESIVIGMAHRGRLNVLSNVVKKPNESIFSEFLGSLDPDSEGSGDVKYHLGMNYERPTPSGKRVYLSLVANPSHLEAKDPVVLGQTRAIQFYANDEQEHSKSMSILLHGDAAFAAQGVVYETMGFHSLPKYSTGGTIHLIINNQIGFTTDPRFARSTPYCSDIAKSIDAPIFHVNGDDVEALVFICKIASEWRATFKKDVVIDIVCYRRHGHNETDQPSFTQPLMYRKIIEQTSTLEKYAKQLIKEGSFSEKDINEHKKCVWDILESSFKKAKNYKPTSREWLTSAWNGFASPRDLTVKNFPHLPTSVDKETLKNLGRKIFLYPKDFNIHPNLKRIIRNRALSIEEEKNIDWATGEALAFATLLMEGCHVRLSGQDVERGTFSQRHAVLHDQENEDTYIPLNFIDPKQAKFVISNSSLSEFGVLGFEYGYSLISPNSLVVWEAQFGDFANNAQCIIDQFIASAEVKWRQRSGIILSLPHGYDGQGPEHSSGRIERYLQLVNDDYRVFPSKERLQRQHQECNIQIAYPTTPANLFHLLRRQIHREFRKPLIMFFSKSLLRHPLACSNLSEFSQNSHFQRILDDPGHENGFLKPRELCNKLILCTGQIYVSLYKERQERKINDTAIVRCEQIHPFHFQGLKECLDSYPNLKELIWCQEEPLNAGAWQYIQPRLKTVLRETQVHKNKKIKYVGRLPSASVATGNKIQHKQEHEELIRNAFESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7P4W2</accession>
    <name>M7P4W2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ADP-ribosylation factor GTPase-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase-activating protein for the ADP ribosylation factor family.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874681.1">
        <property type="nucleotide sequence ID" value="XM_007876490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P4W2"/>
    <dbReference type="STRING" id="1069680.M7P4W2"/>
    <dbReference type="GeneID" id="19896351"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02660"/>
    <dbReference type="eggNOG" id="KOG0521">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002728_0_0_1"/>
    <dbReference type="OMA" id="ITPNAFP"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000252">
        <property type="entry name" value="ARF GTPase activator (Csx2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000017">
        <property type="entry name" value="ARF GTPase activator (Csx2), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045258">
        <property type="entry name" value="ACAP1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180:SF160">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN EFFECTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180">
        <property type="entry name" value="CENTAURIN/ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="566"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="725"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1018" mass="117535" checksum="4AAD14DB5B3064AF" modified="2013-05-29" version="1">MGHVGSRMHEKPAIYIDTDKLKFFFKSIVITNSKDQAPIYITVETYPKTFINISSDREWPIEFIFDPEASTHSFLPFLLKLYADQEIHVKFNISIRLQTPEEIETMCFKGLFFVYGSNIFELDNILASELKDFENIQNCQNVSFLDNISTDGLLEKEFEWSWTWKPHSSKNKYLDGWRNTCYFVQHENNDFSILAKFNFWILQNDLKVLLNEDHSSEKKNALFNSLLCNLNSVVNFNNFDDAFKNEPNDGPLFRAIITALEKKTTVFRYRIKKLIKRAVDLYDSQITKNDANRRFMNTLKKVSESNPIAMKPVLKLYLEAANQQLQSFEYNNALQLQRLIIKPLKCIYEADIKAAERKKKNFEDDSHDYYQFVSRYLSKSDSSKDKKIYKADAKYFAKKRDFELKCFDYYSFMQDLSGGKKEQEILHLFTLYVENQYSTLHRVINVILDLKPGLDSLTQGVQEINKNLRHVSTKREELRRVLEKSKIFVQSNNFFSSTTHQKKSKDSGYKNHCLTSNNYCSSQDNSFDSNVNKLLTTENAEISLYSNEDSKRLEDTNENDSDSISQRRKEGLLWALSRPRGYTDPKVVQKLNWHKYWIVLAGGKLCEYQNWKQAIDLHNIPIDLRMASVKKVCSLDRRFCFEVITPKIRRIYQATSEEDVSSWIKSISKAIESLLEGTSSVSDLSHYKNVDKTPMSKSNGEIFYRNTLPSNLTIEDDRNSIKNAYKLLKIIHDADPIYNVICADCNSSSKAEWCSINIPAILCIECSGVHRSLGSHISKVRSLMLDTTSFTNNLIDFICQTGNKMTNLIYEATYDSVKNLKNIIKPFPTSSREEKYKFIYAKYVDKAFVLYDSDPMKSLLFGIYNKHIESVVQALASGADPNTIDAESGDSALILSLSLSSYELGKNDLNNSYKSQQETFPIAEYLLQNGANLPEYSLSISHEKLSIQARAYLQSKYPKKYLNNEHVSENMNSSVSNNGLLITTDNSLNNFSFFYNEHKNSGKLQKKINSSGKLPKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6A7</accession>
    <name>M7P6A7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED4</name>
        <name evidence="9" type="ORF">PNEG_02340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874344.1">
        <property type="nucleotide sequence ID" value="XM_007876153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P6A7"/>
    <dbReference type="STRING" id="1069680.M7P6A7"/>
    <dbReference type="GeneID" id="19896033"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02340"/>
    <dbReference type="eggNOG" id="ENOG502REXJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1125090_0_0_1"/>
    <dbReference type="OMA" id="THSAFEA"/>
    <dbReference type="OrthoDB" id="1929813at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019258">
        <property type="entry name" value="Mediator_Med4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10018">
        <property type="entry name" value="Med4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="214" mass="24007" checksum="70074ADAB57C886A" modified="2013-05-29" version="1">MNCSAFDTLATTATAFCNLFINPPNPTSILTQTIKLLEANAAFQQLLDQLAIHQRNIIRIKALIDETSALNQQIDKCLQYLLNSRQRLHQTNLSDKTFLSAEKIPHTMLLDYAAKISKYSSAPDGYNPAKGFYGTTPAYFPWPPEDAMRKGVLMAPQVESNLFKKTKSSPIKNDIHVNDSDLITQITPPLKKPKTNVFIGLDLYDPKDQNESNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6Z3</accession>
    <name>M7P6Z3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_01850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873821.1">
        <property type="nucleotide sequence ID" value="XM_007875630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P6Z3"/>
    <dbReference type="STRING" id="1069680.M7P6Z3"/>
    <dbReference type="GeneID" id="19895544"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01850"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="OMA" id="DRCKVTA"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF7">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="10"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR09660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="507" mass="57202" checksum="1AC39CE588C455BA" modified="2013-05-29" version="1">MYTIYHPVAVAAAATIGAMLFGFDISSMSAFVTAPQYLEYFNHPSSLLQGIITSSMPAGSAIASFFSGYFTNKLGHRSINQLGAWVWIVGSIVQATSLNAVHLIIGRFISSIAIGLCSGQIPVWISELSPKRYRGSLVSIFQWSITWGICIMFYLSYGCTKIDGPLSFRIAWGLQMVPGFIFSFLVLFLPQSPRWLASHDRWEEAQFIISKVNRASSSNSPEVIAEIEDIKEAVESDKNGIGYLALFSKGSRTRTFVGFFTQVWQQFTGMNVIMYYVTNVFQMAGYSGVSNLLISSIQYVLNVIMTVPALLFIDRWGRRPTFIYGAILMAILLFAESIFMALGGHYVPNYKGSEYIRWSMEGHKNFANAVIACSYLFVCVFAPTWGPCAWIYVSEIFPHNQRAKANGFCAFANWTFNFILAIFVPTAFKNIQWKTFLIFATFSVTMAIHVYLMFPETCGRSLEEIEHIWKNKIPAWKTKVYKPPKPRCIEKNDEIAIDNKSENKYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7P767</accession>
    <name>M7P767_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873876.1">
        <property type="nucleotide sequence ID" value="XM_007875685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P767"/>
    <dbReference type="STRING" id="1069680.M7P767"/>
    <dbReference type="GeneID" id="19895595"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01901"/>
    <dbReference type="eggNOG" id="KOG2046">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055232_1_1_1"/>
    <dbReference type="OMA" id="WIKTITG"/>
    <dbReference type="OrthoDB" id="21595at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051764">
        <property type="term" value="P:actin crosslink formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21210">
        <property type="entry name" value="CH_SCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF14">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="1">
        <location>
            <begin position="19"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="170" mass="19623" checksum="539365794C27EC4C" modified="2013-05-29" version="1">MSLDRSLRKKMEEKARSNPTFELEARNWIEEVINEKLDPNKDLIDNLHDGVILCKVANAIGPCQIRYKVSSMPFVKMENIAAFLEFVQKLGVPNYDLFQTIDLYERKNTYQVLQCIHSLSRYAVQNLSFHVPALGPKLATSRKIHFTEEQLNKAKNMTNTRQYGYVAGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7P841</accession>
    <name>M7P841_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">26S proteasome non-ATPase regulatory subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873767.1">
        <property type="nucleotide sequence ID" value="XM_007875576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P841"/>
    <dbReference type="STRING" id="1069680.M7P841"/>
    <dbReference type="GeneID" id="19895493"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01799"/>
    <dbReference type="eggNOG" id="KOG4413">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_555632_0_0_1"/>
    <dbReference type="OrthoDB" id="10250600at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019538">
        <property type="entry name" value="PSMD5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13554:SF10">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13554">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10508">
        <property type="entry name" value="Proteasom_PSMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="56243" checksum="66A7599C439D9561" modified="2013-05-29" version="1">MNHLHFEAKRLKDLLYDIEINSESFKLLPLAFEEFALSISDSTRNSCLSFLPELIRALYLPIDPLPNIRVIEKLISTLSWKDICELDLVPHILTGIMCGNEDIELFCLKMLSKSTKAITPNDINENIISCIISCISSKHCSSANKAIEIICDLNLSSDMFRERLLSSFLALSTQFFSSDDSFSSSSMIISRFLTLILKLSSQSFEMFKFLASSSLIDNVMNLCNSNDLLMKLCKFDFLSSLLTLNYTLEWLENHGYFKEAISPFLMSQSSNIDVDTELLIIQSCKFIESMKYISFKDFKRIDSSNNLVSRLVENLSFRSLSSSLYKANLFTIAGMFCFSDDFSEYIYFKLNDMSNLTKTDNGLSALQLIFSSPSDKYTQLFFQQKLSSKAMFDIMMSAKSPFESTRHSALLILKEIVKHPWGILKCVELTPLMEFILSRTTEEYFDRMVKYDIVKIMEKTGRHLLGPWEEEVLRYVMKGVFGTSYQPGVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7P8K1</accession>
    <name>M7P8K1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873402.1">
        <property type="nucleotide sequence ID" value="XM_007875211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P8K1"/>
    <dbReference type="STRING" id="1069680.M7P8K1"/>
    <dbReference type="GeneID" id="19895159"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01463"/>
    <dbReference type="HOGENOM" id="CLU_652312_0_0_1"/>
    <dbReference type="OMA" id="NYQGQWP"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323:SF0">
        <property type="entry name" value="CALCIUM HOMEOSTASIS ENDOPLASMIC RETICULUM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323">
        <property type="entry name" value="SR-RELATED CTD ASSOCIATED FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="29"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="421" mass="49140" checksum="1FA310186787DB91" modified="2013-05-29" version="1">MNTEDREKLEKIKFQLLSELDKHKYSKDSLRFNKNDIIDLIERVKTGRYKAIQSARRWQEEYIVTKELMMYFFKYLVAFSTTMTTFSQRLYILYLINDILSHSFKNNNMDIALEMKSSLLSLLRLGYYAPEAEKDKIEDLLNLWNEKKYFTEITMKATHAGLMVPLAQTSSKPNFSNTPKNHDYIKPFQHGRQGASYWELPAACMIPLLPDASVIKESIHSYISIPPHLCQPITLPSHTSPELLEALNTFYKEESMDLWGFKENSDTENQDIDYEGWSKKFWEKRKEKEKKTSFSCEQEYDANSSGLSSFESSRSKERSESNSSWSYLSPSRSKTLSRSHSRSPSPSQSQKDIFLSNFQDVKKKNYEEQYDSKMYSVSTEISTVPPQPSSTAHFSEKPQTIDNSKSQRTKEIAIKRGWRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7P951</accession>
    <name>M7P951_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01622</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873579.1">
        <property type="nucleotide sequence ID" value="XM_007875388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P951"/>
    <dbReference type="STRING" id="1069680.M7P951"/>
    <dbReference type="GeneID" id="19895316"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01622"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_650727_0_0_1"/>
    <dbReference type="OMA" id="EFFGCIN"/>
    <dbReference type="OrthoDB" id="48651at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF11">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="81"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="166"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="228"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="276"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="315"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="386"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR10370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="422" mass="48669" checksum="2C30AF18DC30292D" modified="2013-05-29" version="1">MGPKRNKGEKLSLSDFLSGSNWADEMEDMPIAPLIEGKETKASFYERDYNDGGYRKDIEISYKHDRSSNKEEIQLPKEPPYTAHLGNLSFNITESEISNFFGEPFITNIRLMRDRIDDRPKGFGYVEFTDLQALVNAISLNGKTLSGRAIKISVAEPPRKGYIDREPVEDRTAGEWRRTSSLPLSESSYEKRSTYERRGHFGNNDRTHNFNDNPRDFSNWECKGPLQDLPELDSFTKKRSHLSSNRRNGDKYRNFGFGDRSYGNSFNSTGTTNIGERPKLVLKPRGEKLEEPPQTLKPSTKPNPFGDARPVDSGARIREIEEKEQKRKEERQASEEQKGFGREKILKDPSYKSDKTDKKERNRRNHSLDFKYDKTEKNKDHKAQNYKIQSVNSSKSTNSTITLETEINIDGWSTVNKLSRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7P9C8</accession>
    <name>M7P9C8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01179</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873094.1">
        <property type="nucleotide sequence ID" value="XM_007874903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P9C8"/>
    <dbReference type="STRING" id="1069680.M7P9C8"/>
    <dbReference type="GeneID" id="19894876"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01179"/>
    <dbReference type="eggNOG" id="KOG0752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_10_3_1"/>
    <dbReference type="OMA" id="MYVCYGA"/>
    <dbReference type="OrthoDB" id="18574at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="15"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="122"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="215"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR10465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="35923" checksum="9235DCE5D0DA04D6" modified="2013-05-29" version="1">MKEKSLENTSTKKISPSIKSAISGGISGFTTRFIISPFDVIKIRMQLQILPVFPLKEHNSTNYPFQRIIRLVKQIIHQEGILALWKGNCFSQILYMSYGSCQFFTYAKCKFFLDRIFPEKTYNSGKTFVSGAIAGAVATTASYPFDLLRTRFAAQGVSKVYLSIPHSIKSVYISEGIKGFYRGINASILQIVPYMGTVFGLYESSKTYLSNIGYSSSWTDALAGLVSGTVGKTIVFPLDLIRKRLQVQGPTRKKYFYKDIPVYNKVIKTGIIIFKSEGFLGLYKGWWISVLRAAPSTAITLWVYQRSLNFINKLEEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M7P9N9</accession>
    <name>M7P9N9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="19">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PNEG_01290</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">NADH-dependent reductase for DPH3 and cytochrome b5. Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. By reducing DPH3, also involved in the formation of the tRNA wobble base modification mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), mediated by the elongator complex. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>2 Fe(3+)-[Dph3] + NADH = 2 Fe(2+)-[Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71231"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:71232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 19">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer. Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="19"/>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873214.1">
        <property type="nucleotide sequence ID" value="XM_007875023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P9N9"/>
    <dbReference type="STRING" id="1069680.M7P9N9"/>
    <dbReference type="GeneID" id="19894987"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01290"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_9_0_1"/>
    <dbReference type="OMA" id="VQIFMCG"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000019">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF184">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 18 19" id="KW-0274">FAD</keyword>
    <keyword evidence="5 18 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="11 19" id="KW-0520">NAD</keyword>
    <keyword evidence="10 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="20">
        <location>
            <begin position="52"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EMR10585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="294" mass="32951" checksum="201A3832EF17BD36" modified="2013-05-29" version="1">MTQKQNTLFHGICIPGVVIINKKYLFHGIVLAFTLSLLKIYRGRSCISLHPDKFQEFELIEKTIINYNSAIYRFALAKANDILGLPIGQHIMVSVTIDGKKVSRPYTPCSSDDERGYFDLLIKSYPTGKVSKYIGEMKIGQTISVKGPRGKMRYYSGLVKEFGMIAGGTGITPMLQIIRAILKNPEDKTKISLIFANVTEADILLKDEFDILANKYSNFRIYYVLNNPPFNWTGGVGYVTKDIIKEYCPPPGPDMKLLLCGPPPMIVAMKKEIALLGYDTPSLVSKLTDQVFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAH5</accession>
    <name>M7PAH5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DASH complex subunit DUO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Outer kinetochore protein DUO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PNEG_00991</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DUO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872905.1">
        <property type="nucleotide sequence ID" value="XM_007874714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PAH5"/>
    <dbReference type="STRING" id="1069680.M7PAH5"/>
    <dbReference type="GeneID" id="19894689"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00991"/>
    <dbReference type="eggNOG" id="ENOG502SCC0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1496848_0_0_1"/>
    <dbReference type="OrthoDB" id="5599235at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013960">
        <property type="entry name" value="DASH_Duo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08651">
        <property type="entry name" value="DASH_Duo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="151"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMR10845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="180" mass="20958" checksum="882BF3896459F876" modified="2013-05-29" version="1">MEFQERLLGSSSETQMTGQSGSFSDCNMSERDSMLLQELNGVKNLNKVIEKVICGLLKVQEDMEHVDKTVKDVDKLLEKWIKILNQTEHTQRLILNKKWHGATKDILDAENELLKMKEQAQETKSFEVSEKKIKETKRELSNISYISNSDKMDDKRKVKQKETTKTYTHNRKLFSTTNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>M7PBT5</accession>
    <name>M7PBT5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cyclin-dependent kinase 1</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PNEG_00359</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Plays a key role in the control of the eukaryotic cell cycle. Required for entry into S-phase and mitosis. Acts as a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II. May function in concert with npp-16 to arrest prophase blastomeres in response to anoxia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Interacts with cks-1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872232.1">
        <property type="nucleotide sequence ID" value="XM_007874041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PBT5"/>
    <dbReference type="STRING" id="1069680.M7PBT5"/>
    <dbReference type="GeneID" id="19894057"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00359"/>
    <dbReference type="eggNOG" id="KOG0594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="OMA" id="YLYQITR"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07835">
        <property type="entry name" value="STKc_CDK1_CdkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000706">
        <property type="entry name" value="Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000027">
        <property type="entry name" value="Putative Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF254">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="4"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMR11330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="300" mass="34404" checksum="E591CD1FC88457A6" modified="2013-05-29" version="1">MEQYQRLEKIGEGTYGVVYKAKDLESGTIVALKKIRLEAEDEGVPSTAIREISLLKEMHNDNVVRLLNIIHQESRLYLVFEFLDLDLKKYMNSIPKDMMLGAEMIKKFMSQLVSGVKYCHSHRILHRDLKPQNLLIDREGNLKLADFGLARAFGVPLRGYTHEVVTLWYRAPEVLLGGRQYATALDIWSIGCIFAEMATKKPLFPGDSEIDEIFRIFRILGTPDENSWPGITSYPDFKATFPKWSPKNLGELITELDGDGIDLLQKCLRYYPAERISAKKALDHPYFDDFINLDRSNVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7PC50</accession>
    <name>M7PC50_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875586.1">
        <property type="nucleotide sequence ID" value="XM_007877395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PC50"/>
    <dbReference type="STRING" id="1069680.M7PC50"/>
    <dbReference type="GeneID" id="19897183"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03496"/>
    <dbReference type="eggNOG" id="KOG4689">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046583_0_0_1"/>
    <dbReference type="OMA" id="YIHWYTC"/>
    <dbReference type="OrthoDB" id="2017974at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18727">
        <property type="entry name" value="PIN_Swt1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052626">
        <property type="entry name" value="SWT1_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161:SF0">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="1">
        <location>
            <begin position="54"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="432" mass="50834" checksum="25F158DCB1CFF9EF" modified="2013-05-29" version="1">MGSEKQRKKKDEWMIIEENIDMTNPFVFNDEKREEFYKKLFIERDEEYVLDDKVILVVDTNFVISHLSLISDLSKQCESYKYIIVFPWATIQELNGLKSSRNMYVSHTGEDIAFSVRKATDFIYKSLLQKENSIRGQKMTEVIDATLTGDDSILDCCRYWHEKRLLKTILLSNDKNLSIKVMIHGIYSISYEPGMTLELLLDEISKKLDHYLKHKNFDELQNIDMEIDDIQGDSFQSSESIDDCSFLRNTKQNLEFKEDLMYVDCIPLKDTPLSDECRTFLTELLQDITIIIIEASKILLKKHMVRVLGNDFSAEYLLKGCAFPPKRIDDLFHIIQKHWNTIFKELFKTHAYKERIIEMTKAYQLWSKWALSGIGIGPSPIQLLNWVEEIITFWKTLATVSTTDIVQDKEMQYKITLWRQQVKNLNEKIFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCA3</accession>
    <name>M7PCA3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c oxidase subunit 12, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cytochrome c oxidase polypeptide VIb</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00545</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872436.1">
        <property type="nucleotide sequence ID" value="XM_007874245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCA3"/>
    <dbReference type="STRING" id="1069680.M7PCA3"/>
    <dbReference type="GeneID" id="19894243"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00545"/>
    <dbReference type="eggNOG" id="KOG3057">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133964_2_0_1"/>
    <dbReference type="OMA" id="NEWIAKW"/>
    <dbReference type="OrthoDB" id="1107506at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00926">
        <property type="entry name" value="Cyt_c_Oxidase_VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.140:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003213">
        <property type="entry name" value="Cyt_c_oxidase_su6B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46281:SF8">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 12, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46281">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00074891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00082359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR11535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="82" mass="9943" checksum="589B3B90BFF92396" modified="2013-05-29" version="1">MSEELNLKQLKTAGFDSNFPNMNQTKRCYQNYINYYKCINIHSDNFILCRDFWSTYQSLCPNEWKQQWDTQREEGKFPGTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7PD84</accession>
    <name>M7PD84_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ELYS-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_03250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875317.1">
        <property type="nucleotide sequence ID" value="XM_007877126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PD84"/>
    <dbReference type="STRING" id="1069680.M7PD84"/>
    <dbReference type="GeneID" id="19896937"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03250"/>
    <dbReference type="eggNOG" id="ENOG502S4G4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070360_0_0_1"/>
    <dbReference type="OMA" id="EGLWHLD"/>
    <dbReference type="OrthoDB" id="20729at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025151">
        <property type="entry name" value="ELYS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13934">
        <property type="entry name" value="ELYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELYS-like" evidence="3">
        <location>
            <begin position="41"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="307" mass="35771" checksum="78FFF47951D07C95" modified="2013-05-29" version="1">MEIKAPKNSFEKIYCQKSKDFPYNIQLLNLIKNCRKIHGGKLFFDLLLADIARISDSEKLYPPKSLVELKKLYFSIENSQIDELKKNCYHYYLLKDSNMGEKFSNDVFIPIIYRKLMDSYWYLDRMKFEEAFSSLCTPNLVPNFPEKILSSFYLLSGEQGAHMTITYADVMSLPLDTDEKLDVYMSALIKVDVLSAYSFLKSCPNLKATFFRKIIEHCLSVQQSTKWILELPFTKDEEEQLISYLKEASYASSKNILFVYLINKGKRIEAIELSKSIGNDFFRNIEIADFVNGLNKSLLPIERKMIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7PD86</accession>
    <name>M7PD86_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation initiation factor eIF2B subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">eIF2B GDP-GTP exchange factor subunit epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_03255</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875322.1">
        <property type="nucleotide sequence ID" value="XM_007877131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PD86"/>
    <dbReference type="STRING" id="1069680.M7PD86"/>
    <dbReference type="GeneID" id="19896942"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03255"/>
    <dbReference type="eggNOG" id="KOG1461">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012507_1_0_1"/>
    <dbReference type="OMA" id="LAQSCKI"/>
    <dbReference type="OrthoDB" id="424572at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04197">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05787">
        <property type="entry name" value="LbH_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11558">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000066">
        <property type="entry name" value="Translation initiation factor eIF-2B subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035543">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051956">
        <property type="entry name" value="eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044123">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="8">
        <location>
            <begin position="502"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="673" mass="76636" checksum="BDD4BB7B7B696DF8" modified="2013-05-29" version="1">MLFEETIVLTDSFDGRFKPLTLEKPRCLLLLANMPLIEYTFEFLALGGVQEVYVFCHTHAHEIKEYIEKSKWNHIASPFSVQTIISSENLSAGDALRELDTRKSIESDFVLVNGDVVSNICLKEVIAEHNKRRQADKNAIMSILVRKVSPLHRIRIGSEASIFVINSDTSECLHHELIKMKPRTKTISINGEIFDKHQKVEIRNDLIDCQIDICSPEVPALFTENFDYQDIRKDFVHGILTSDLLGKTIYCHVIEDNYAACVQNLQAYNVITKDVLSRWSYPFVPDSNLLSNQSFKYMRGHIYKEDDVILSRSVNLKSKVVIGSETKILENTVIMTATIGKNCLIGNNVTIENSFIWNNVIIGDGCRISNSIIADNVILGKNCIIQEGTIISFGVQISDGIIISGNIRLTNFLPEKNIKNNTFELTDTMVVGVNGKGYIYQDLELSDVEDAETESVDCSFLVYNLKEISISDTSLSSISSKESNTPRRCSSTTVTIMSDESDTTNEYFYREALAGLEQAFDENHMVDSVILEMHSLRMSTNVSYSEVRSTIIMAFLNYILKLISEEGKSIANIIEQNIKKWIILLRKMTFANEDKEEIILTLQELCSKRIEYMRFFPPLLKLFYNEDIVEEDDIYSWFDNPKSQTGSSEKKRLYNIGSKFVIWLKNAEEDSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7PDD5</accession>
    <name>M7PDD5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_03297</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875372.1">
        <property type="nucleotide sequence ID" value="XM_007877181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PDD5"/>
    <dbReference type="STRING" id="1069680.M7PDD5"/>
    <dbReference type="GeneID" id="19896984"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03297"/>
    <dbReference type="eggNOG" id="KOG3504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169255_0_0_1"/>
    <dbReference type="OrthoDB" id="996720at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002673">
        <property type="entry name" value="Ribosomal_eL29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01779">
        <property type="entry name" value="Ribosomal_L29e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="94" mass="10955" checksum="24F9BD6696E4E55F" modified="2013-05-29" version="1">MAKSKNHTNHNQNKKAHRNGIRRPKIGCFLSLKYVDPKFRLNRKYAVRGTCRALRKTHVVCTAMEHTFSRLLKDIAVQKRVSCSTILHKYCCVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M7PE07</accession>
    <name>M7PE07_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0538 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874914.1">
        <property type="nucleotide sequence ID" value="XM_007876723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PE07"/>
    <dbReference type="GeneID" id="19896564"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02877"/>
    <dbReference type="eggNOG" id="KOG4147">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117792_0_0_1"/>
    <dbReference type="OMA" id="YRNVKNH"/>
    <dbReference type="OrthoDB" id="937at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018794">
        <property type="entry name" value="UPF0538"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18444">
        <property type="entry name" value="UPF0538 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18444:SF9">
        <property type="entry name" value="UPF0538 PROTEIN C2ORF76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10209">
        <property type="entry name" value="DUF2340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="121" mass="14333" checksum="44340B45DEAE09AD" modified="2013-05-29" version="1">MAILTIRLIRSFTYRVIKYLVLCEINLEKTTVKDLQTLIFNEIYKNPEYKAYQLPKFDTLKIYVHSQSAKTSNRIINLDHDEWILDPCMTLERCGRMKQNYLSLIDQNMNSLKQIPKKSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7PER1</accession>
    <name>M7PER1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP citrate synthase</fullName>
            <ecNumber evidence="4">2.3.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PNEG_02733</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA</text>
            <dbReference type="Rhea" id="RHEA:21160"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.3.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874760.1">
        <property type="nucleotide sequence ID" value="XM_007876569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PER1"/>
    <dbReference type="STRING" id="1069680.M7PER1"/>
    <dbReference type="GeneID" id="19896424"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02733"/>
    <dbReference type="eggNOG" id="KOG1254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006587_3_1_1"/>
    <dbReference type="OMA" id="DMHVSGI"/>
    <dbReference type="OrthoDB" id="5295093at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000004">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.110:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032263">
        <property type="entry name" value="Citrate-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056749">
        <property type="entry name" value="Citrate_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF1">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16114">
        <property type="entry name" value="Citrate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24948">
        <property type="entry name" value="Citrate_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-citrate synthase ATP-grasp" evidence="16">
        <location>
            <begin position="2"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase citrate-binding" evidence="15">
        <location>
            <begin position="302"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF24948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMR08954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="500" mass="55898" checksum="2956B9A7E4F84FC4" modified="2013-05-29" version="1">MSTKAIREYDGKAILGYWLKHAAPIVAYEQVSDTPVAQSTSLAQIIFDSPHTYSSDAYTAHVAHVLDKTESIYPWLLNTEYLVAKPDQLIKRRGKLGLICLKNNWKDTRCWIERFAGKEQRVENVSGILNTFLCEPFVPHADDSEYYLSIMSAREGDLIMFTHQGGIDVGNVEAKAQKILIPINLKEFPTQKILEETLLQEVPTYVRESLIRFIIRLYTVFVTCHFTYLEINPLVVEKKGKNVEIYYLDLAAKLDQTAEFEASEKWAISRAPHVLNISHCEASSKVNVDQGPPIVFPAPFGREMTKEEKYIAELDSKTGASLKLTILNPNGRIWTLVAGGGASVVYADAIAVVGYADQLANYGEYSGAPTETQTYEYSRTIFDLMTRGPLHPEGKYLFIGGGIANFTNVISTFKGVIRAMKDYASAFHAHKVQIWVRRAGPNYQEGLKAIKAAGEELSLPLKVFGPETHVSEIVYFALLGKKPAEPIIGINSKNDMYINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7PEU1</accession>
    <name>M7PEU1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cell morphogenesis protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02759</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874790.1">
        <property type="nucleotide sequence ID" value="XM_007876599.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7PEU1"/>
    <dbReference type="GeneID" id="19896450"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02759"/>
    <dbReference type="eggNOG" id="KOG1825">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000325_1_0_1"/>
    <dbReference type="OMA" id="MRADTMK"/>
    <dbReference type="OrthoDB" id="6287725at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005933">
        <property type="term" value="C:cellular bud"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007118">
        <property type="term" value="P:budding cell apical bud growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025614">
        <property type="entry name" value="Cell_morpho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025481">
        <property type="entry name" value="Cell_Morphogen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029473">
        <property type="entry name" value="MOR2-PAG1_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295:SF30">
        <property type="entry name" value="PROTEIN FURRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14225">
        <property type="entry name" value="MOR2-PAG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14228">
        <property type="entry name" value="MOR2-PAG1_mid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14222">
        <property type="entry name" value="MOR2-PAG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell morphogenesis protein N-terminal" evidence="1">
        <location>
            <begin position="233"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="3">
        <location>
            <begin position="1312"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="3">
        <location>
            <begin position="1617"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis protein C-terminal" evidence="2">
        <location>
            <begin position="1826"/>
            <end position="2076"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2305" mass="265068" checksum="66D2A082C4039AB8" modified="2013-05-29" version="1">MASNAFLFSEHHSPINKGSLEVLSKNSISYVPNSHILLSSGIQCGLNDTSCMEKSLVQNLSKEPLLYSQVSASDQEAFSPSNHTVLSSHNNVFSSRFSCHIPYNSSKHEFKTPNEYVFYILFAQFVCVSEKKINTILEYPLDWEPNIAKIVGEGVDPIFDKILKSLGYIARHKPKPIIDSFMYWRKSKLEASIASILNKEYLFSEGKIKDGSQIQNSNSSTIQFNRRVSVIKDRRSLVSIYILCRALIEIIKQVSADTLGDELGNKLEEIVFNQLRSTNPRVLSNSIIRLANWNLFAELLGWMSKIRFSSVSDRFIADLEKFKGNITKEKELKVEMVIHGMKYLKIKLCPEDALEESSDFIASLARFFQETSCYRIKYAYATLFHRSMLSMVDSATAELNFPSWAGTVEMLYPKVIKMSMKVRLWNMAFSLATTLLCVSPKDMFLANWLNLIGSNILKLKDKTTRIFLVTCIARMTWVYMFRYSESLNTTTKKLDNLILMLFPPGKRYLGFSESCILALVAFIRFIGLKHPDYCFKNIIFPLMSADTSKFSQDFLVVDDLSPERMIIAMKAVLAIVYDLSCFGNRPSFPVIIEEIPAYSDDQLNLLYDVINKSIIKDYYELFSKMVFKIAYVCDQSYGYKIEEIDLSLLKVSSLSNESYLSGDLKDNRIYHELLIVSFEALSKCLFKEVSLVKVVDMICKNLLHFDLGVSKAASNALELIAKQNKAQIVLSAVSKLVIKYDELFLKEYNVSATANQNIFSCTESILRLFVNLLKIWIKQIEDKVNEKKKLSNCLNQITSDVDSEGRVEMTSILILVEEIESNGLFFLFSQSRIIRCYAFEMLHLVVKIDEVIGKCGKNSVENLSLSQSIRHEDFTYSRIINIFYHDGLRLLSFPVDSLSVVEYNRLQKVHDGKRNDILIKISESESTIDTAIWFRVFPKFVKLCFEKFPINVIFCRNIACLRLMRMQKFIMKTIEISRKNNSLDILSKYSNRHSNFSDIVLEQWKLYLIVACSTLTSTDDEALKYIQKYEQKKNVMSIFFEKTISAHSVFQEILLLLETNCIAIKDSIVSALEFINVNVYRVLLEDLQLVLKKSTENSHLFHFRISEKFPQTTLYDLLTEVTHILQLTSHFLMEDSIIQDEWILNTLVSYIKDVRIFIGELNLQREWEYLKLKRYFCGLLENVYGGICRTSDPLRWMSFDDRISYFCMIEEWCGYGSCETLAQKHEEYIKQLVLDQYKDVRDFNPIIASLEIEKKNLQMAALNCMTSLCSGRIIPVIEDNTNKKDVVSFDIDSFFRWTDALFLSQNERVSDLGCKALFNLLRYNLDYPVLLEKSMQKCYGSHMESKSTQCYFSVLVDVLINATMFPYSIHQVLVLCFFRIGDKNLNVRINALRLLKYSEELVFGKSLVSGFEAAIFNNTVSIYRRGQYLLLSRYSKEYSDLAFIVFSECLKCFYLVSEKLQKDIIIILLPWVQVIELQFDTCNEDLGLSSYMVLVNLLEISVKYGDRFQNEIEELWTALVSGPYVGNIKIILDFFVSKCIERKDPAFVIFAKHVIIYLNRSPLGFKIMDTLFNCLQNPRSMVPQLRELTHYSNTNATYSYMAILDDFFPLPKKPIIFSHGQIALIFVVDLITETDFSIAAILPLALHLAFIHLDHYIDLVKDQAKEMLITLLNCINFYSLKESELLKIKVNFVSILRFKDSELFWTYDDLNHSKKNPKIPEQMKKMVDDVLKICSVEYNDLRQIWGKVAITWATLCPVRHLACRSFEIFRCLLLPLDQNILANMLARLSNTICDNSLDIQGFAMEILVTLKVLTEKLNESEFKNYPQLFWGVVASLNTIHEQEFVQCILILEEIMKKIDLGFPSNVNFLLSVFPLKWSGDFDGLQSLILKGLRSSTSYDITLRVLDFIVGLPNNDIIGNNERLLFAVLANLPRFLDALENSTLSENVINCAKNLEAMASSQGLLELEKIISSFSKSRIRVKEDFIKQIIFIIHDIYFPEWETSALLFMLRMLSNKRKWIKIKIMEILKVMLLYIDTSKPKFSGFGADLIFPLLRLLKTEYVQLAIEVLEKINIISGGSIDKHVLRMILSNKTILKEFGKIEELFGIPDENGWAVPMASFTATITRSNVHSVFCTCTVASSNTSLITSDIQFHVDDYHGTDNHSGTAFSKNSDDCEGDSLDDMVSTLHSLDVFFTEDALNTSCDYESFIVDTGFDSMEKSQNVYENRVDSILVNFNEKKLKETLNSSLVGLFDSTKINDNILNKNMDIVTNSQSKPSITTGCLFSETDRSYSFSEHCIMKNDDKWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7PF57</accession>
    <name>M7PF57_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ras-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874451.1">
        <property type="nucleotide sequence ID" value="XM_007876260.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7PF57"/>
    <dbReference type="GeneID" id="19896136"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02443"/>
    <dbReference type="eggNOG" id="KOG2128">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000972_1_0_1"/>
    <dbReference type="OMA" id="KGVLVHW"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903479">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21206">
        <property type="entry name" value="CH_IQGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="129"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="1">
        <location>
            <begin position="686"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1332" mass="156572" checksum="12535928552D2762" modified="2013-05-29" version="1">MTGSLPSTPSKGLTEVPTNCFTYREGPLSRLSLSPRKLQISNDLIQKPSLDDLKKLNKSTVSHLRTLCKLSLLNNCEEICIPGVTKGAEDVTGLHGRIRLQKGIENRVYSWHKTWMDKQRANIQAYEYLCHIGEAKEWIELCIGEDIHPILELEESLRDGVVLAKLARVFFPELVPKIFEATKLQFRHSDNINRFFQFIERINLPDVFRFELTDLYEKKNIPKVIYCIHALSFMLSHIGLAASMSNLVGKLEFTDEEIKNTQRDLDIAGVSLPNFKNIGNTLAGELNIPQEKRINKCDESPFEKEAFGLKCQSVCRGYLLRKRLIEAFRILLDQEDVISLLQAYIRGFFVRKLFLEKMNEYHKFKKWIKNIQTVSRGYIIRKFYIGWKDSIDYYKEDIVKIQAIIRGYLLRKKISSLFNDFMKKEGLIVKMQSYSRGLLFRRAFESHIMHFHSMNRYSIFLQAQSRGVLLRKRLHYILGSLLFEGDMIVILQSYIRGILVRNKFNRKMKYYKENIQKIIKIQSFVRGKLQGQAYKNLTSGKNPPVATIKNFIHLLSDSNYDFQEEIEMESLRKMIVQRVRANQNAEEHIYQLDLKIALLVKNMVTLDEVICHQKRFSSKILLHSNSQGLLKDPFDLKALNKSSREKLELYQDFFFLLQTCPEYFARLFCSYCERRASEDNIKQLENFLACIFGYAQKRREEYFLLKLLRRSIIEELIKVENIQEFFERDSLWIRIIVSYNRSVKERKYLKELFEPLIEKIIKNDDLDLESDPAMIYHSIISKEERITGQKSKRRLNLEKTDAIQDPETRDLFIKHLQDLRDWTESFINAIEINIHKMPFGLRYIAREVYRTLLTRFPDGNPLEILKFIGYIIYYRYFDPVINAPDVFNIIDGPITTLQRRNLAEISKMLSQITTGELFDENDVFLCPLNLYLETAIQKMMKIFKTVINVQDAEQYFEMDEFDDLTCTQKPILYIKISDIFAIHSLVYNEIEIMAPNQDDQLRDIIKQLGLLSNNEEFMKISDTEIDLTLNPRLVHIENPDSEIRALFIETKYYIFYIIRIQTGLNLMEILIQPVHPNDEIKWEQILIEESKNNKHSNIYTRNNIYNIKEMTFSQIKAAALDNILKLESKGIISRSNYYQDLLNAIATDIRTKHRRRIQRQMELESARQTLAHLDNKALYLKSQLESYNNYIEKSLISLQTKKGKKKQVVPFTKQYFHLRNLKRSGQVPKFGSHKYSGRQLFDKGVIVSINNHEEKDYGKFYFTLSSNDVGVFIIEVTSGSLHFPDSILKLKLDDLLEAQYNNIEVLPLFEGLVKINVNLMLHMIFKKFYSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M7PFZ5</accession>
    <name>M7PFZ5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02326</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874328.1">
        <property type="nucleotide sequence ID" value="XM_007876137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PFZ5"/>
    <dbReference type="STRING" id="1069680.M7PFZ5"/>
    <dbReference type="GeneID" id="19896019"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02326"/>
    <dbReference type="eggNOG" id="KOG0425">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_10_1_1"/>
    <dbReference type="OMA" id="MFEWEVM"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23795">
        <property type="entry name" value="UBCc_UBE2G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000025">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="5"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="168" mass="19471" checksum="B5BE69D551097EB3" modified="2013-05-29" version="1">MVNYASETILKRQLKEIQKHPIQGFSAGLVDDNNVYEWEVLIIGPEDTLYEGGFFKCHLSFPREYPHLPPKMRFITELYHPNVYEDGHVCISILHPPGEDKFGYEDASERWRAVHTPETILLSVISMLSSPNFDSPANVEAAKHWRDDPRGFEKKVRKLVRQSAENFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M7PH92</accession>
    <name>M7PH92_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873970.1">
        <property type="nucleotide sequence ID" value="XM_007875779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PH92"/>
    <dbReference type="GeneID" id="19895684"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01990"/>
    <dbReference type="HOGENOM" id="CLU_2655541_0_0_1"/>
    <dbReference type="OrthoDB" id="5374117at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031833">
        <property type="entry name" value="DUF4748"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15932">
        <property type="entry name" value="DUF4748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="76" mass="8789" checksum="B9CF8D3BFF222E64" modified="2013-05-29" version="1">MNKPWSIAVGWVSLTIAAGIGYYFAKKDIKARHRDRILESQKIQEKAKLEEIKTRNVDMNSDELSKFHVSKEQGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7PHU7</accession>
    <name>M7PHU7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01788</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873756.1">
        <property type="nucleotide sequence ID" value="XM_007875565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PHU7"/>
    <dbReference type="STRING" id="1069680.M7PHU7"/>
    <dbReference type="GeneID" id="19895482"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01788"/>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_9_3_1"/>
    <dbReference type="OMA" id="NAGHECI"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017064">
        <property type="term" value="F:fatty acid amide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1300.10:FF:000003">
        <property type="entry name" value="Amidase signature enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052096">
        <property type="entry name" value="Endocannabinoid_amidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45847">
        <property type="entry name" value="FATTY ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45847:SF6">
        <property type="entry name" value="FATTY ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="62"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="213"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="558" mass="62666" checksum="3458A764AD6E3C71" modified="2013-05-29" version="1">MVSFQNVKRIKQKERQAAIRKAMVLVGSSFPEDGDEEFLTASAEMIAKKIAAREPRWTSENVVKAYIRSSIRNNEKINFITEVFFVEAIEQAILLDKELELGKSPRGPLHGVPVSFKDTYNISGYDSSLGISTFVCKPSLDDSALVKMIKDMGGVILFKTNVPQTLFTFECSNPIFGRTLNPFSCKYTCGGSSGGEAASLSSNSSALGFGSDIGGSLRIPAHYCGVCSLKPSSDRFPLKGHFGIVEGFEGIRVVAGPMTRSVSDLKFITKAILLSRPELYDFSCIPLPWREPLQPENNLKVFGYYFEDEFTLTSPACRRAVRMVVDSLKAAGHKVVEIRPPSSFDAVEIFIGLSSSDGYKSIYDVIKKDPLEKNLRLFVLSSWIPYFIKSIIGYIIENIICDLKLSLVFKAVRKKKFTEYCHLVHRRNLYRNEWFKIWNYYKLDGIIAPINPLPALPHNGTTNVAPIAASTFIYNLLNYSVGCLPVTFVDSSIDILSDEYKKWDGIMHQKLYQSTQPLYDPDKMHGLPVGVQVIGQQWQEEKVIEMMFDVENALRAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M7PI50</accession>
    <name>M7PI50_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-ketoglutarate dehydrogenase component 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873353.1">
        <property type="nucleotide sequence ID" value="XM_007875162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PI50"/>
    <dbReference type="GeneID" id="19895112"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01415"/>
    <dbReference type="HOGENOM" id="CLU_2795017_0_0_1"/>
    <dbReference type="OrthoDB" id="2116030at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020373">
        <property type="entry name" value="Kgd4/YMR-31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10937">
        <property type="entry name" value="Kgd4-YMR31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="68" mass="7892" checksum="FA414FD3C2E7922B" modified="2013-05-29" version="1">MHIHRPLIRFLGKNRFIKPQTPKNHIPDTSKELSINISSLPIHFHRRLLTPEEIEAITSGGATTRHYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7PI66</accession>
    <name>M7PI66_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01428</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873368.1">
        <property type="nucleotide sequence ID" value="XM_007875177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PI66"/>
    <dbReference type="STRING" id="1069680.M7PI66"/>
    <dbReference type="GeneID" id="19895125"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01428"/>
    <dbReference type="eggNOG" id="KOG1996">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025002_1_0_1"/>
    <dbReference type="OMA" id="GPMSEVI"/>
    <dbReference type="OrthoDB" id="5411533at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12374">
        <property type="entry name" value="RRM_UHM_SPF45_PUF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000382">
        <property type="entry name" value="G-patch domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040052">
        <property type="entry name" value="RBM17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288:SF8">
        <property type="entry name" value="SPLICING FACTOR 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288">
        <property type="entry name" value="SPLICING FACTOR 45 SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="G-patch" evidence="8">
        <location>
            <begin position="345"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="406"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="57017" checksum="34416874009E1387" modified="2013-05-29" version="1">MSLYGKINVNLSSKEDINKGSIEREPVTYVVQQTEVKKGTISQEIDEHRRMTSAALQFQPIRRPLQAKKNVKKPLSSVSLPFEPLKSHPVFHNVSSLDYWSHKDEDLNESYDITESRKIAKNRGKKKKTKSFETVSLSWDDSYDPFKPNDYEEYKMSDESVQEMIDWKNKQEGKAKADDIEKYKNMEQFAPPANYSPSHSSTVIGFSQATEPVSAISLDETAEEAYARRVAMSQNRNVEVDYRSSYSTEPTYEIDLPKQSFPPLSSSEDPVSVELSHEVLDNPLAISDDKQHLQTFSKTTIIREPQMYDIKTTNSSEFMSSSMDSENLKIPESLGFQTNSNMPGQKKFAERLMKKYGWEKGKGLGASNDGIVNPLIVKQSKDRKNTGSIINKNHPEKTGKFGKLSKVILLTNVSELETVDDELSQEIGDECNKSYGKVERCFIYKNMNSTLASDIVRVFVLFTDTISALRAVNALNGRLFGGKEIKVRFYDFDKFENGEYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7PKC0</accession>
    <name>M7PKC0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-catenin-like protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01045</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872958.1">
        <property type="nucleotide sequence ID" value="XM_007874767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PKC0"/>
    <dbReference type="STRING" id="1069680.M7PKC0"/>
    <dbReference type="GeneID" id="19894743"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01045"/>
    <dbReference type="eggNOG" id="KOG2734">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017098_0_0_1"/>
    <dbReference type="OMA" id="TDWREQE"/>
    <dbReference type="OrthoDB" id="1898821at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001136">
        <property type="entry name" value="Beta-catenin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039678">
        <property type="entry name" value="CTNNBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013180">
        <property type="entry name" value="CTNNBL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978:SF0">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1 NUCLEAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08216">
        <property type="entry name" value="CTNNBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01156">
        <property type="entry name" value="DUF1716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta-catenin-like protein 1 N-terminal" evidence="7">
        <location>
            <begin position="70"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="90"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="576" mass="66287" checksum="3D354B14AEC6CB55" modified="2013-05-29" version="1">MEIDDLFKKPEPVLKKRKIVPINPTETFKNIQNTYVEKNGRNNTGFGNTLDNSVSYGVGEEDERFFGGGLTKGQEDILDFIDENDKNEAIEQEKIDASSLKKMVLKLERAITKNQELRMKYSENPEKFLSSEADLDSEIKALSVLSGYPELYSEILRLGCYKSLIGLLSHENADIAISVLELLDELIDDDIDHNENQMKLLINSLIEAQLFNALTDNMTRFNEFNESDRRGVFLVLSILENISSFSHTFSENAVSSTNILEWLLQRLQIKEFPISQNKQYVAELLAIYTSSSSFIRKKIIDLNGVDIFLHILSPYRKRDPVKDIEEEFVENIFDCLCSLLEEQEGKEKFIDAEGVELCLIMLRHGKISKYRSLKVLDHALGGFHSISCCERLVEAAGLKIIFSIFMKKPPFKVIEYLLGIFLSLLRLLPIDSISRIRTLAKFVEKDYEKILRLMELRKFYKFRVDSANKKMMEQLKGLSQDERIEKESEIYFDLVDAGLYSLQVIDLILAWLCIEDVGIKKKVQELLEIEGQDLLSIKAVLQEYLNNMQVEDSESDKSDNVMKEIEMVKTLLTLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7PKK1</accession>
    <name>M7PKK1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Squalene synthase</fullName>
            <shortName evidence="15">SQS</shortName>
            <shortName evidence="15">SS</shortName>
            <ecNumber evidence="4 15">2.5.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PNEG_00587</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 (2E,6E)-farnesyl diphosphate + NADH + H(+) = squalene + 2 diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:32299"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 (2E,6E)-farnesyl diphosphate + NADPH + H(+) = squalene + 2 diphosphate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:32295"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.21" evidence="4 15"/>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR10984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872482.1">
        <property type="nucleotide sequence ID" value="XM_007874291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PKK1"/>
    <dbReference type="STRING" id="1069680.M7PKK1"/>
    <dbReference type="GeneID" id="19894285"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00587"/>
    <dbReference type="eggNOG" id="KOG1459">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031981_2_1_1"/>
    <dbReference type="OMA" id="GEACQLM"/>
    <dbReference type="OrthoDB" id="431150at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045338">
        <property type="term" value="P:farnesyl diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902767">
        <property type="term" value="P:isoprenoid biosynthetic process via mevalonate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000003">
        <property type="entry name" value="Farnesyl-diphosphate farnesyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006449">
        <property type="entry name" value="Squal_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044844">
        <property type="entry name" value="Trans_IPPS_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01559">
        <property type="entry name" value="squal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626">
        <property type="entry name" value="FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626:SF2">
        <property type="entry name" value="SQUALENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMR10984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="465" mass="54622" checksum="D5F16F4036CA16D4" modified="2013-05-29" version="1">MAIWTDYLRHPREFKEFCQYKLFYTPLYQRLPDQETHNCRQCYELLIQTSRSFGRVIQELRPELRESVMVFYLVLRGLDTIEDDMNFDSKKKIQLLRTFYTHIDEKGWKFSESSLSAKDGMLLKSFDKVIEEFLVLKKEYQDIIRSITYEMGNGMADFIKSAHFKTQGIQSIRDYNLYCFYVAGLVGEGLNRLFLVSKVEHDLEGLTELSHTMGLFLQKTNIIRDYREDLHHQRVFWPKEIWSKYVDNFIDFLAPENQEKGLHCLSEMILDALTHVPDCLYYLCNLHDQSVFNFCAIPQTMAIATLALVFRNPNVFRKNLKIRKGEACSLIMRTTNRRNLCGIFLKYIRIIHLKNTPSDPNFFKISVACGKVEQWVESVFPSDKPGLSLCSQKPLHESSTEFLIDKEAFYIFLISSIFLAIIASLMIYLAHLFGARWDFTQVCKIFDFLKSIFSDTLSIVKRDEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>M7PM27</accession>
    <name>M7PM27_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">RuvB-like helicase</fullName>
            <ecNumber evidence="15">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PNEG_00535</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="15"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872425.1">
        <property type="nucleotide sequence ID" value="XM_007874234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PM27"/>
    <dbReference type="STRING" id="1069680.M7PM27"/>
    <dbReference type="GeneID" id="19894233"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00535"/>
    <dbReference type="eggNOG" id="KOG1942">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028311_1_1_1"/>
    <dbReference type="OMA" id="RTLPYNK"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097255">
        <property type="term" value="C:R2TP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000001">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 15" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="59"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMR11524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="453" mass="50316" checksum="389B83048A7FF7D6" modified="2013-05-29" version="1">MTIKASTRENRIAAHSHIRNLGLKEDGSAEQVSSGWVGQQQARQACGLVVDLIKLRKMAGRGVLLAGGSGTGKTALALAIAQELGSRVPFCPMVASEVYSNEIKKTEVLMENIRRSIGLRVKETKEVYEGEVLEITPEEAENPLGGYGKTIAHVIITLKTFKGTKQLKLDPSIYESIQKERVTVGDVIYIEANTGAVKRVGRSDTYATEFDLEAEEYVPIPKGEVHKKKEIVQDVTLHDLDIANVRPQGGQDIMSMMGQIMKQKRTEITDKLRKEINKVVNKYIDQGIAELIPGVLFIDEVHMLDIECFTYLNRALESTIAPIVIFASNRGMCVIKGTEDIVSPHGIPIDLLDRLLIIRTLPYTSEEIKIIIRLRAKTEELQITDAALEKLTEKGVTSSLRYAIQLLTPSSILAKVNGRQEIDVHDIEESVVLFLDGKESAKVVHTHDKRFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7PM62</accession>
    <name>M7PM62_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Splicing factor 3B subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_00004</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871854.1">
        <property type="nucleotide sequence ID" value="XM_007873663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PM62"/>
    <dbReference type="STRING" id="1069680.M7PM62"/>
    <dbReference type="GeneID" id="19893702"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00004"/>
    <dbReference type="eggNOG" id="KOG0213">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002242_0_1_1"/>
    <dbReference type="OMA" id="LVMNYVW"/>
    <dbReference type="OrthoDB" id="438939at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000066">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000069">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000810">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015016">
        <property type="entry name" value="SF3b_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08920">
        <property type="entry name" value="SF3b1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Splicing factor 3B subunit 1" evidence="9">
        <location>
            <begin position="224"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="10">
        <location>
            <begin position="988"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="133"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="157"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR11559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1206" mass="136740" checksum="30B9AA64F58709C9" modified="2013-05-29" version="1">MSDPEFEEICLLQSGRDCKKKNDSFSSKDSSFDKIKTEELKINFDKEYDENLYSNDRDSIEYNTTIPINIDDEEQNSKNETHKLVGQYTVPAHLLNEFSNEDSELITKVRSKRQIVSRESDYQKRRFDQILTPARYDAFSEDRKDKDSDSGRSFADIMRERDLEREEERVHRAIAKKKEVQSNDDKEDKESKPRKRRWDTSEPSSDDMSNKSNWNDVQDTPVIKKRSRWDQTPAPVALGSATDAPTPKQSRWDQTPVIGITPIGLQGLQTPLPNMIPQMPISFGTDVSQRFYDFSDEELDEILPVKGFKVLDPPPGYASIRTPVRKLVATPVFSNDCGFTMQEIDNAANKQLNAGLPTDIPGVGDLAFFKQEDMKYFGKLMDSTDESELSVEELKERKIMRLLLKIKNGTPSMRKSALRQITDKAREFGAGSLFNQILPLLMERTLEDQERHLLVKVIDRILYKLDDLVRPYVHKILVVIEPLLIDEDYYARVEGREIISNLSKAAGLAHMISTMRPDIDHVDEYVRNTTARAFSVVASALGIPALLPFLKAVCRSKKSWQARHTGVKIVQQIAILMGCAILPHLTSLVDAIGGGLEDEQQKVRIITALAIAALAEAAAPYGFESFDIVLRPLWKGVQKHRGKGLAAFLKATGYIIPLMDAEYANHYTTQIMKILIREFQSPDEEMKKIVLKVVSQSAATDGVDSAYLRVEVMPEFFKNFWVRRMALDRRNYRQVVETTVELAQKVGVTEIIEKIVDHLKDESEPYRKMAVETIEKIIAGLGAVDINKRLEERLIDGVLYAFQEQSMEDIVMLNGFGTVVNALGMRCKPYLPQIVSTILWRLNNKSAKVRQQSADLISRIAVVMKTCGEEQLMGKLGVVLYEYLGEEYPEVLGSILGALKSIVNVVGMTSMTPPIKDLLPRLTPILRNRHEKVQENTIDLVGRIADRGSEFVSAREWMRICFELLDMLKAHKKGIRRAAVNTFGFIAKAIGPQDVLATLLNNLKVQERQNRVCTTVAIAIVAETCAPFTVLPAVMNEYRVPELNVQNGVLKSLSFLFEYIGEMGKDYIYAVVPLLCDALTDRDQVHRQTAATTVSHLSLGVVGLGCEDAMIHLLNTVWPNIFEQSPHLINAVINAIDGIRTAIGPGILMMYILQGLFHPSRKVRDVYWRLYNNMYVQQADSMVPYYPNIEDDECSHFFRHEIQVWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7PMV2</accession>
    <name>M7PMV2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00201</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872069.1">
        <property type="nucleotide sequence ID" value="XM_007873878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PMV2"/>
    <dbReference type="STRING" id="1069680.M7PMV2"/>
    <dbReference type="GeneID" id="19893899"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00201"/>
    <dbReference type="eggNOG" id="ENOG502REBM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_302875_0_0_1"/>
    <dbReference type="OrthoDB" id="2123378at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052007">
        <property type="entry name" value="Bud4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36100">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36100:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="829"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR11774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="984" mass="111931" checksum="536056F478602C49" modified="2013-05-29" version="1">MSEISVVSVKEQAGSGLNLKSEQNLSHDESELANSPLCAFFYEVNRIRQGNDRKKSRDSKNSSQSLLSSSYNLSKKDLSGIKTAAFFNRRYGGLHSTESLKENTGLYLRRNAMLSRATVDSGNTFDDCLSIKTSSDYEMYNGNNVCKVIDSPLKAPTVHNVEYREYYDKNPCVKEPEKPVNIFKDEVSEKIPEKKSFFLKGSRKSSGGKNVEKKSTLRSISLNIKNLITSIVSNSDDHTKQSQIENNGESLQKENEFSGSSVSQTENAFGANLSNEKSNITKSTFSEFYNRNLRKDIRNANENEAPKMKEDVLKCSVEDEEKNKNNDVTASAFEDLSNGYHITRKNYQTYVSNDSQEMFLDDFKYKYDSDDVPCDDRIENNIQKSKSNVEESLTYESEPGVSQRLPSFCKLDAIEIGNFGLDDFMIRKSSNISTKEINEFKSKFHEDMALSEEKINDSDTTLEKKTHVKPNDFSNTLTKAYSSFEIADSDDGKYKSDIQSLNNNKNTNIGQSTADENSGVSITLPLLGDPLLLDFDVSLNDVSDAIDRVIEVQKRGYIMRQNINIVHASSNDICEKNIKRERYESPKVDDIYEKNEKNPVLKFDKTKDLAINKVPQDNSIGKKPDSGLLFIRVIEIENLDLPLPEDKTLRFCCTLDNGQHYITTPWISFTKNAKINEEFELIANDDLEFTLTLRLDYQPLVDNKKKDFIFSRIFSTSKKKGALNLSNPLNCCLSNNGSIGRSYLSLKMFKDHAFGCLYTTTVTCMNEWTKKAVVKGKKQQVLKVKSYIICQLKINAFYVPFVPGQAKETLPKSLSACVKDIKNAEWVSKLHYEGLLIQHGGDCLYRKKRYFRLSGLKLTSYHESSKSIRSNINLAKVKMVLNDQQLSINSKKMTQVMHSENSKQSTILEGDNDYMFAQNGFCIKFFNGEIINFYADSEDEKVRWVRVLDAVIKKAGQVKPWSLYVLQKQKVMKRFPLKSVLKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWV2</accession>
    <name>A0A0W4ZWV2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_04340</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I 75 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="KTW32849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875614.2">
        <property type="nucleotide sequence ID" value="XM_007877423.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWV2"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZWV2"/>
    <dbReference type="GeneID" id="19897209"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04340"/>
    <dbReference type="eggNOG" id="KOG2282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3306">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QAMAYGV"/>
    <dbReference type="OrthoDB" id="10249365at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02773">
        <property type="entry name" value="MopB_Res-Cmplx1_Nad11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.740:FF:000012">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] iron-sulfur protein 1 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.740:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.210:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054351">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010228">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015405">
        <property type="entry name" value="NDUFS1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050123">
        <property type="entry name" value="Prok_molybdopt-oxidoreductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01973">
        <property type="entry name" value="NuoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF13">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105">
        <property type="entry name" value="RESPIRATORY NITRATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13510">
        <property type="entry name" value="Fer2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22151">
        <property type="entry name" value="Fer4_NDSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22117">
        <property type="entry name" value="Fer4_Nqo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09326">
        <property type="entry name" value="NADH_dhqG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53706">
        <property type="entry name" value="Formate dehydrogenase/DMSO reductase, domains 1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00642">
        <property type="entry name" value="COMPLEX1_75K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00643">
        <property type="entry name" value="COMPLEX1_75K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="12">
        <location>
            <begin position="33"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="14">
        <location>
            <begin position="111"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="13">
        <location>
            <begin position="250"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KTW32849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="732" mass="82023" checksum="3E951E96FFAEBDC3" modified="2016-03-16" version="1">MFFITRHWNKCVRNDISLSIFSRTFFTSRIIREEVEIEIDGKPVMIEQGSALIQACEKAGVQIPRFCYHERLQIAGNCRMCLVEVEKTPKPVASCAIPVLPGMKVKTNSPMVYKAREGVMEFLLANHPLDCPICDQGGECDLQDQSMRYGADRGRFYEYTGKRAVEDKDLGPLIKTAMTRCIHCTRCVRFINELAGATELGTTGRGSDMQIGTYLENHLNSELSGNIIDLCPVGALTSKPYAFRARPWELKRTDSIDIHDAVGSSISINSRGLEIMRILPRLNDDVNEEWINDKTRFANDGLKVQRLQVPLIRRNDKFVPATWDQALSEISSAYKRISPIGDEFKAISGHLADAESLICLKDLANRLGSENLALDQPEGNKPLPHGVDIRTNYLFNSTIRGIEQAGFILLVGTNPRHEAAVLNSRIRKSWLRSNNIEIAMVGENSSTTYDYKYIGHNAIALKNALNGDIGKKLKEAERPMIIIGSAVSEQPDARFIYETIGKFVIENKNKFLTPEWNGYNVLQRAASRNAAYDIGFVTFSPKTAKVKPKFIYLLGADELTDNDIPKDSFVVYQGHHGDLGAQYADVILPSSAYTEQSGTYVNVEGRAQVTRAAINSLGVARENWKIIRALSEYLNVTLPYDDIRGVRNRLNEIAPSLTRYNVIEFCSMPDLGMKIQIHDHNKGSEASGHRLVNPITDFYLTDVISRNSKTMAKCSLHFSKKISQEKSIQKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWZ1</accession>
    <name>A0A0W4ZWZ1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_04307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="KTW32888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613362.1">
        <property type="nucleotide sequence ID" value="XM_019757825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWZ1"/>
    <dbReference type="GeneID" id="30671589"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04307"/>
    <dbReference type="OrthoDB" id="5323049at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KTW32888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="83" mass="9779" checksum="E931FD04AD88B685" modified="2016-03-16" version="1">MNILDKVISKLLKPKNKTLSKDCEISDLMHFNEKSPEINIKHTKYMRFIENKKNIFMLTLDTLININFPLKGINPSNHLYKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M1FNZ3</accession>
    <name>M1FNZ3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">NADH-ubiquinone oxidoreductase chain 3</fullName>
            <ecNumber evidence="9">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">nad3</name>
    </gene>
    <organism>
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="10"/>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="FASEB J." volume="27" first="1962" last="1972">
            <title>Sequencing and characterization of the complete mitochondrial genomes of three Pneumocystis species provide new insights into divergence between human and rodent Pneumocystis.</title>
            <authorList>
                <person name="Ma L"/>
                <person name="Huang DW"/>
                <person name="Cuomo CA"/>
                <person name="Sykes S"/>
                <person name="Fantoni G"/>
                <person name="Das B"/>
                <person name="Sherman BT"/>
                <person name="Yang J"/>
                <person name="Huber C"/>
                <person name="Xia Y"/>
                <person name="Davey E"/>
                <person name="Kutty G"/>
                <person name="Bishop L"/>
                <person name="Sassi M"/>
                <person name="Lempicki RA Kovacs.JA."/>
            </authorList>
            <dbReference type="PubMed" id="23392351"/>
            <dbReference type="DOI" id="10.1096/fj.12-224444"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the complex I subunit 3 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="JX499144">
        <property type="protein sequence ID" value="AFR90417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_007475007.1">
        <property type="nucleotide sequence ID" value="NC_020332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M1FNZ3"/>
    <dbReference type="STRING" id="1069680.M1FNZ3"/>
    <dbReference type="GeneID" id="14657956"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030964">
        <property type="term" value="C:NADH dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1610">
        <property type="entry name" value="NADH:ubiquinone/plastoquinone oxidoreductase, chain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000440">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038430">
        <property type="entry name" value="NDAH_ubi_oxred_su3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11058">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11058:SF9">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00507">
        <property type="entry name" value="Oxidored_q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFR90417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="112" mass="13014" checksum="2C080232225864F5" modified="2013-05-01" version="1">MTTLVIVALGISLSLVFLNRIFSPTRPSLEKVSPFECGFSSFHQTRNPFNIYYYLIGLLFLVFDLEILLIYPFALSTTSYGFYIFNLFLFFLTIGFIYEYGKGVLKFKNDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7NID7</accession>
    <name>M7NID7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MED9</name>
        <name evidence="8" type="ORF">PNEG_03168</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875231.1">
        <property type="nucleotide sequence ID" value="XM_007877040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NID7"/>
    <dbReference type="GeneID" id="19896855"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03168"/>
    <dbReference type="HOGENOM" id="CLU_2543523_0_0_1"/>
    <dbReference type="OrthoDB" id="2563275at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011425">
        <property type="entry name" value="Med9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07544">
        <property type="entry name" value="Med9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="83" mass="9675" checksum="C07EDF318C0C0B74" modified="2013-05-29" version="1">MDISDTDLIPQIVQILKTTKKDDLKEFNKEVTKLYQKVSNIRKMIESLPGKDLSILDQEGVIKRLEKQISMQKKLLSEINMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NIN5</accession>
    <name>M7NIN5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dihydrolipoyllysine-residue succinyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_03283</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="5"/>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875356.1">
        <property type="nucleotide sequence ID" value="XM_007877165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NIN5"/>
    <dbReference type="STRING" id="1069680.M7NIN5"/>
    <dbReference type="GeneID" id="19896970"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03283"/>
    <dbReference type="eggNOG" id="KOG0559">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_0_1_1"/>
    <dbReference type="OMA" id="NMPQTAV"/>
    <dbReference type="OrthoDB" id="5391403at2759"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000006">
        <property type="entry name" value="Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004309">
        <property type="entry name" value="PRK05704.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="13">
        <location>
            <begin position="46"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR08453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="436" mass="49295" checksum="EEC7AF742D01324E" modified="2013-05-29" version="1">MPKLYNFYNFSITNNIFKILCIRNFSNIRCTPHKIWRLHEIQTYATKTIQVPQMAESITEGTLKQWNKRIGDFVNQDEEIATIETDKIDVSINTPVSGILKEILKHEEDIVQTGQDICIIELSNESPKNTIDSKLFESTKNKETIEESKLSESNKNNIFSETDSKKNITNKRKNETENLSQTIPISENSEFDSSNISKVFNNRQEYSVKMNRMRLRIASRLKESQNAAAFLTTFNEVDMSSVIEMRSLYKEEILKKTGIKLGFMSAFIKASVTALKEIPVINSSITGPNGGDTIIYRNYVDISVAVATPKGLVTPVIRNVETLNFLEIEKTISELSSKARNNKLALEDMAGGTFTISNGGVFGSMLSTPIINLPQTAILGLHAIKDRPVVVNGQIVIRPMMYLALTYDHRIVDGRESVTFLHLIKEFIEDPRKLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7NIW1</accession>
    <name>M7NIW1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_03024</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875075.1">
        <property type="nucleotide sequence ID" value="XM_007876884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NIW1"/>
    <dbReference type="STRING" id="1069680.M7NIW1"/>
    <dbReference type="GeneID" id="19896711"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03024"/>
    <dbReference type="eggNOG" id="KOG1965">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005912_5_1_1"/>
    <dbReference type="OMA" id="FTYVRRF"/>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF187">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="11">
        <location>
            <begin position="30"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR08543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="591" mass="67858" checksum="702E49C4C02B4722" modified="2013-05-29" version="1">MEIGFYDLKTNEQLTSWGLLILMVLLIMALWTSYYLQAKKIKSIHETVISIFLGMIVGLLIEEFQNTDIQKIVTFNYGYFFNLLLPPIILNSGYELHQELFFKNLGAIVTFAFVGTFVSAVITGLLTYIWALTGLEQVKISWIEALKFGATISATDPVTILSIFRTYGVDPTLYTIIFGESLLNDSVSIVMFETLQRFYNKEINIIDVFIGIGQFFITFIISLAIGILAGIFIALLLKYSHLRRFPYIESCIITLIAYASYLFSNGCHMSGIVSLLFCAIALKHYAFYNMSTQTQFSTKFLFKILSQLSENFIFVYLGISLFTQTNLVYKPLLILVTMFFVCIARYISIFSISKFINMVMQSYNIIFCEKLPASYQIMLFWSGLRGAVGVALIQAVEGEAANTLKATILVLVVLTVIIFGGTTPQMLEIVGIHMGIINHEDDYHIEDFYNENPSLEENISDRFIFKRTGSLSNSQKINQYIYESDQHSKQLDSLDLLYHSDNSSERKKDQDNIYKKSFDSDIFFPTVMEYTKLEDISYTSYEMTRENIFQDNEQLYASDNHIKWFKDFDSKILMPLVIEKDIMSKKNNYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NK10</accession>
    <name>M7NK10_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TAP42-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_02741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874769.1">
        <property type="nucleotide sequence ID" value="XM_007876578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NK10"/>
    <dbReference type="STRING" id="1069680.M7NK10"/>
    <dbReference type="GeneID" id="19896432"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02741"/>
    <dbReference type="eggNOG" id="KOG2830">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041824_2_0_1"/>
    <dbReference type="OMA" id="EYELCEA"/>
    <dbReference type="OrthoDB" id="10261753at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.540">
        <property type="entry name" value="TAP42-like family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038511">
        <property type="entry name" value="TAP42/TAP46-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007304">
        <property type="entry name" value="TAP46-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933:SF9">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04177">
        <property type="entry name" value="TAP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="40289" checksum="257336E6E56CCB63" modified="2013-05-29" version="1">MDIENQPQENRSLRELFDSAENFRRKIEEGSTELLAECISLYEKCHYLARKLSLFSNNEGIDEISTSEIRFFLIDYYIAELLDKNTTSNRSSTILSSRNLFVSFLTLCENYTLLTSSDKALFNYLNSNETYNEGYINRISNVSRREEKIQRYKREKELNKNISTFLKNPSKDENDLRKHFLEVVQLAIFKSLQSIEQLDLELKMIEISKDKDQDSINDYHRTETENNIHSTLKTKNNFQKDNPLLDKHGKPLRPFTIIAKREQLKNNVFGPDHNLPTMTIDEYLKEEAKKGNILSNKEIPQNKKEIDQDNMEEIDIEMYKARKWDEFKEENPKGWGNRANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NK73</accession>
    <name>M7NK73_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02806</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09033.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613295.1">
        <property type="nucleotide sequence ID" value="XM_019757746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NK73"/>
    <dbReference type="STRING" id="1069680.M7NK73"/>
    <dbReference type="GeneID" id="19896495"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02806"/>
    <dbReference type="eggNOG" id="KOG2661">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029002_3_1_1"/>
    <dbReference type="OMA" id="RFNCYSE"/>
    <dbReference type="OrthoDB" id="7464992at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF1">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="8">
        <location>
            <begin position="106"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09033.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="306" mass="36234" checksum="A900B7F6872EBC8E" modified="2016-03-16" version="2">MIKFRYILIKKQAFYQNWVSKRYIHYQRFRRTSFGLENRSFWCISGVISLIAGVYYFSHIEYVPISNRRRFNDVSPQFEKKISQETYRQIIHQYRGRILPSNHPLTRRVQQVMIRLIRASKLKDIDWEIHVIDDPQRNAFILPGGKVFVFSGILPICKNEDGLAVVLAHETAHQIARHSAEKLSFTKLVLFGYFIISLFYDPSILGRAIIDICLLKPNSRKLETEADYIGLMLMSEACYDPNEAPRLWKRMSISETKTPPKWFSTHPTHDNRITKINEWMPEAYSKYTENDCSKYSRGFFRSFSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7NM62</accession>
    <name>M7NM62_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_03442</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875529.1">
        <property type="nucleotide sequence ID" value="XM_007877338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NM62"/>
    <dbReference type="STRING" id="1069680.M7NM62"/>
    <dbReference type="GeneID" id="19897129"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03442"/>
    <dbReference type="eggNOG" id="ENOG502S752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1180638_0_0_1"/>
    <dbReference type="OrthoDB" id="1654884at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="26955" checksum="16A5A592C66B76FA" modified="2013-05-29" version="1">MLILRYIIDYKQLHVYFLNKSNIFCLNLPLRIAFFSHLSLIYKDKFKIGNLADLDKFLIKANDTDSSRKEDINESVFDEDSSISLDLNPKSSLLSNTFTEIINKPFHYNSSQTKEKIYHLHAYCSDNNTIITLTNSHYNPVICISSGMVGFKKAQRGGYEAGYQVCMSLFKKMMQKDIYPTQFEIILRGFGKGREAIFKCVNGIEGLPFKSSVSRITDATRINFGGVRGRKVRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMD8</accession>
    <name>M7NMD8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_03441</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875528.1">
        <property type="nucleotide sequence ID" value="XM_007877337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMD8"/>
    <dbReference type="STRING" id="1069680.M7NMD8"/>
    <dbReference type="GeneID" id="19897128"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03441"/>
    <dbReference type="eggNOG" id="KOG1318">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_891737_0_0_1"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11387">
        <property type="entry name" value="bHLHzip_USF_MITF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45776">
        <property type="entry name" value="MIP04163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45776:SF2">
        <property type="entry name" value="MIP04163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="173"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="312" mass="36172" checksum="F13527D860057A6C" modified="2013-05-29" version="1">MMDINRTMHMENREQNGYCIQQIPSFRQNLVHNHQYCSYLKGNSIISIDELAELNLNSSVNTVIHDIGIASDSQFPASRNLNLSYTGDFYSIDVMPIAIENSKAIQSMSMPIRMDDCQSSQIYPKDSFKSFFDSNSENMIYKKIKNESTVFIEDPFMSFNVFDDKRLLEKYRKRRESHNAVERRRRDNINEKIQELASLVSKNPFKDKIKLNMDSGDKGYSDFKLNKGEILQQSVNYIQCLQNYINELNSRSKLLENEVIRLGGDINFVNKIKPISYIPLNIKGMSSNDCDNDSFSSIHSKNDFCDELDVDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMJ2</accession>
    <name>M7NMJ2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Survival Motor Neuron Gemin2-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873615.1">
        <property type="nucleotide sequence ID" value="XM_007875424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMJ2"/>
    <dbReference type="STRING" id="1069680.M7NMJ2"/>
    <dbReference type="GeneID" id="19895348"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01654"/>
    <dbReference type="eggNOG" id="KOG4327">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093937_1_0_1"/>
    <dbReference type="OMA" id="MMSWYFA"/>
    <dbReference type="OrthoDB" id="197400at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22851">
        <property type="entry name" value="SMN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040424">
        <property type="entry name" value="Smn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049481">
        <property type="entry name" value="SMN_G2-BD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267:SF1">
        <property type="entry name" value="SURVIVAL MOTOR NEURON PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267">
        <property type="entry name" value="SURVIVAL MOTOR NEURON-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20636">
        <property type="entry name" value="SMN_G2-BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20635">
        <property type="entry name" value="SMN_YG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival Motor Neuron Gemin2-binding" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="152" mass="17529" checksum="4393A677B8763F0C" modified="2013-05-29" version="1">MTLDGDNASEEKLSYEEIWDDSMLIAAWDAAVHEYKTYHSNVNQDDNKNLEAQSLCVLDSDFQNNCINNESPKESINEIDSDEIFKICQNNDSEKDSEKIKDTFIKSTSITPPLQIFNNDHILKNLLMSWYYAGYYTGYYAGQNSIKNEKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NML9</accession>
    <name>M7NML9_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_03211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875274.1">
        <property type="nucleotide sequence ID" value="XM_007877083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NML9"/>
    <dbReference type="STRING" id="1069680.M7NML9"/>
    <dbReference type="GeneID" id="19896898"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03211"/>
    <dbReference type="eggNOG" id="KOG3419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100590_5_0_1"/>
    <dbReference type="OMA" id="GFYNPIA"/>
    <dbReference type="OrthoDB" id="407221at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_bS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_bS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_bS16_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919:SF20">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="Ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="82" mass="9603" checksum="04EFAFA015090942" modified="2013-05-29" version="1">MTMVVKIRLQRFGIKKYPFYHIVVCNARTARQSKPIEKLGTYDPIPREDGTKNMEINFLRTKYWLGVGAQPTDVVYKLLEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN82</accession>
    <name>M7NN82_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_03057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875113.1">
        <property type="nucleotide sequence ID" value="XM_007876922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN82"/>
    <dbReference type="STRING" id="1069680.M7NN82"/>
    <dbReference type="GeneID" id="19896744"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03057"/>
    <dbReference type="HOGENOM" id="CLU_084655_0_0_1"/>
    <dbReference type="OrthoDB" id="774557at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029005">
        <property type="entry name" value="LIM-bd/SEUSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10378">
        <property type="entry name" value="LIM DOMAIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01803">
        <property type="entry name" value="LIM_bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="243" mass="27387" checksum="A507BFAD23E9D4E1" modified="2013-05-29" version="1">MSRSHNNYPTENSVIGCSETAQPGVAILLLLQFIDGLSSTQKRYDLAGWKAFVHSYFTDYAMMRLSFVSPQTTYPTPYAAQNAQMEHTSRVFELSTLVLPIFLWTNHENGVTQMQFVLGAVKEQITVAHGYVVACPQAKLIYWYSNGSQVVAEGHLCVQFTPAILKMEWFEFITLRSDEYVLRDMARSNLPLSPVNDLGITRKALRCLEMGESLTDMYALMVASQVNRLGPLKTLSHFVSLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN88</accession>
    <name>M7NN88_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ima1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01427</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873367.1">
        <property type="nucleotide sequence ID" value="XM_007875176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN88"/>
    <dbReference type="STRING" id="1069680.M7NN88"/>
    <dbReference type="GeneID" id="19895124"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01427"/>
    <dbReference type="eggNOG" id="KOG4623">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_418624_0_0_1"/>
    <dbReference type="OMA" id="ICEMCAP"/>
    <dbReference type="OrthoDB" id="5966927at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034506">
        <property type="term" value="C:chromosome, centromeric core domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034992">
        <property type="term" value="C:microtubule organizing center attachment site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071765">
        <property type="term" value="P:nuclear inner membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042321">
        <property type="entry name" value="Ima1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018617">
        <property type="entry name" value="Ima1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28538">
        <property type="entry name" value="INTEGRAL INNER NUCLEAR MEMBRANE PROTEIN IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28538:SF1">
        <property type="entry name" value="INTEGRAL INNER NUCLEAR MEMBRANE PROTEIN IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09779">
        <property type="entry name" value="Ima1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="540"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="569"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="606"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Ima1 N-terminal" evidence="7">
        <location>
            <begin position="15"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="655" mass="77015" checksum="79EDBEE5D970266B" modified="2013-05-29" version="1">MGFLPFNTKETANKIRCFYCNSSFSKKQVKNMREWVCFVCQARNYMDSKGNTEDVPFYAANKNDHLNIRYTALSSNQTELSPFCQTCMKNHLFIVNALASYLPSEEDPDYDVYLSALPSYREFLEERYPMVCDLCFPHIQKHLAKKNYIAKSMTLGGWLLSSKKMHGSRHSQSRLFLWVQLFIWSFRGLGWWVFTVFVILYYILGFFIPSVFLKNTYEIIPFWSTRSFSKCVAILFDKSVSFGTCLFLYKLFIRKLIFWGIFVILWDYTWISQISKSYHRVSGKKYYYICQIFIHIIRAIAEFILSERISDASIYSEISLVLFFISIIHLVLIFKCIYFIPPALISLYDSNSRGFSVDSKQKLNTEFKMVEKKSSDNDKNLSVPLSNNCRLEECRHNVDLCDDFMQLDPPEVVPFKMDIGNSSLHNNPSFGFSKGIKLPLPPKTSMYSNVQQSNRSFNSQKENYFLRSKSNIFKTNQKDDDDDDEIASQRFFAPEETTNWIGNYFFSCLNRHKLTWNEVISVLWALEIMIINILNLGKFSYYSSILGSFGIACSIATGSWFLRKTYIKLIFIGTVVSFFYYLFIYINHYDEDFEVFLKTSKTFFIYNTLITAFYSCFSLRILWIIRFLWSYRPLKAKQGCSQKKSKIWGKYAYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNH7</accession>
    <name>M7NNH7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleolar protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Pumilio domain-containing protein NOP9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02957</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875002.1">
        <property type="nucleotide sequence ID" value="XM_007876811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNH7"/>
    <dbReference type="STRING" id="1069680.M7NNH7"/>
    <dbReference type="GeneID" id="19896644"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02957"/>
    <dbReference type="eggNOG" id="KOG2188">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008720_1_1_1"/>
    <dbReference type="OMA" id="HHLVRNF"/>
    <dbReference type="OrthoDB" id="392571at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040000">
        <property type="entry name" value="NOP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Pumilio" evidence="6">
        <location>
            <begin position="341"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="678" mass="79469" checksum="216C0A5DF918417C" modified="2013-05-29" version="1">MSVKKRRNRKTNIFIEKTNENSVHKEEPFFFGTLSLEDEKYFKGVEETLMTHHFSQEDYKLFIDNTFAEIEGKELKLAIHPLYSKTLESLLQILSPIQLKKYFQSLIGNFKRLIFDCFGSHVCETLLIRSAYIVSTENIYSVFQDNNEILVTMENLILFMCNEISDMLMKFADHKYASYVFRQLLLVLHGSIFQDNLSSKRTTKNKRKTRLLSQTISTKQLTMPASFFEKKKSILDNIDTKYSVTQIRNLAFNQYGSQIISTLLLIEKSLVDNDKERKQNLLEKLIFGDFKDISFRSNSSEKIESDSFMETLLRDQVGSHIFESIIEFSSKEILSKLYVIYFKDKILRVSKHPIGNYVLQKFIEKNNNYKILNEITEEIVMHFKELIDIGHIGILVSLINVCSQITLISTKLLNVLKECFGGSETHIKNNIFPLILNLDPRNENNSMKNFEKELNNDNRIVDQIKVQGAHLIKSLFSLPYEMYYFLIESFLLQNKKVILYYATNKIGSCIVETILKLPPLLASDRRKLLNNFFESYAYLSCDPFGSHIVDACLYTSIGLNSYRERIANELLKSREIIEDNYYGKRVWKNWHINLFENKYSEWKKNINSFVKKGLSESKEDKITNIHISDIDFLNDANKYTSSLLTLCNNKQKEKLEDRFNNDLEEIGMLFRKYKKKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNL6</accession>
    <name>M7NNL6_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874648.1">
        <property type="nucleotide sequence ID" value="XM_007876457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNL6"/>
    <dbReference type="GeneID" id="19896320"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02629"/>
    <dbReference type="HOGENOM" id="CLU_458634_0_0_1"/>
    <dbReference type="OrthoDB" id="5364963at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="595" mass="69610" checksum="17167CD5558B6004" modified="2013-05-29" version="1">MEHETKSFDEKEEYKKLFKIRDEIFMNMQATMQSSGMEFFNSNMKIKPPLIKSKSLGPQRYPQTLSKTFLKYKQLPSPSADVSLEDDRSRLERMLRARIEKRKADAKLLMEQGPSKKHIEQKTFSSQIHYKKNIKTWDEIKQNKEASNCDMIFSPSDIQKDSSPDLKHTQKLSVSKSFAYHNEESKYNETYNENNEQAIDFSSSSMAIPGLRVSAHICEENIGKSTMPTITQNVKENTRNNKVISGNSSIKSPSLSLESKLTSHDFQTYESNIQNTSRSSSFEYKPRSPTSRPHLSLLSSPKVAENIDESEKLTETKSVSESKLHYSHITKENSKIEDEAKNLKENKRIDCYTEQGDTSNSTKQHPYEPYKQITSPRPMHWKRDFYPYYQRRSTPTWHGPQNYSGHFLPRDDPSTYYQDRSYFSAHPPPSIGLHNLYTGPYDYDPYYISEFPPIRPSLSPRMTHLYPSHSIHFPHASPFHQSPSLHRYAHDKYFTPAYLPHPYLLHHSPRYDDSMTFSHDSGHFYQPSRNTCEWENLRNCDLSIEHSTSYPLSFREQYETILPYETYLHTEQSSLDTKHSINDRNNESTNWNRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNN0</accession>
    <name>M7NNN0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873493.1">
        <property type="nucleotide sequence ID" value="XM_007875302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNN0"/>
    <dbReference type="STRING" id="1069680.M7NNN0"/>
    <dbReference type="GeneID" id="19895241"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01546"/>
    <dbReference type="eggNOG" id="ENOG502RXWY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1603437_0_0_1"/>
    <dbReference type="OMA" id="PRRAIWH"/>
    <dbReference type="OrthoDB" id="2281895at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040030">
        <property type="entry name" value="Ribosomal_mL57"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L15, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="1">
        <location>
            <begin position="4"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="166" mass="19533" checksum="E4BEE6CD3651D713" modified="2013-05-29" version="1">MNSFENILKFYSRLFNMDEKEIELFLPRDLLWQTLTHKTYFHGKYPYNEKLAFQGRFVLKFHISLKIVESISIDKNNDIFTLEKIEEFISPETLGPLALEYGILEVLRWKPAYKDIMKSGLLKVASESLCAIVGAIFLHRGGAVTKKFIEEKIFIKNNRLEFNNYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNT6</accession>
    <name>M7NNT6_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_02703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874728.1">
        <property type="nucleotide sequence ID" value="XM_007876537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNT6"/>
    <dbReference type="GeneID" id="19896394"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02703"/>
    <dbReference type="HOGENOM" id="CLU_2655540_0_0_1"/>
    <dbReference type="OrthoDB" id="5406332at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="76" mass="8865" checksum="10A2DFCE7B18DD5B" modified="2013-05-29" version="1">MEHSKKQRISLKNKNFYVAEETIDLEELNRRQSALNVLESWDKQAMHAISSNTSTGHIRERMRAIITGINLIKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNU0</accession>
    <name>M7NNU0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chaperone DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01615</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873573.1">
        <property type="nucleotide sequence ID" value="XM_007875382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNU0"/>
    <dbReference type="STRING" id="1069680.M7NNU0"/>
    <dbReference type="GeneID" id="19895310"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01615"/>
    <dbReference type="eggNOG" id="KOG0712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_10_0_1"/>
    <dbReference type="OMA" id="IVFHIVE"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000003">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="6"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="132"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="132"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="44267" checksum="1A82AD52A8472553" modified="2013-05-29" version="1">MVLDTRFYDILGVNPEASQVEIKKAFHKLALHNHPDKVRESEREEASIRFREAQNAYDVLRDPETRIIYDTYGLDGVEDCNNVMIDDLYSEMFEEMGINGLGRESMHKESFKNTKKDVYYDYEITLEELYRGKNVKMAGTRNIICPTCKGSGRKAYSGTKKCVFCDGKGIMTALKQIRPGMIIQQEFECQKCDGTGEAVQEKDRCKKCKGIKTVTEKNFYQIKINKGTQDGEKIVFYGEADQEPGMETGDLIIIIKQRKHDRFERSGCNLKSNLNITLSEALCGFSRVVLKTLDGRGLYMTHPPGKIMYPGQILVIQGEGMPKSSDSDENGDLYLEVVVEFPPNDFFKETQLKSLLALLPPNPTEITDLKIVSDVEYKSGNIENYKIDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP06</accession>
    <name>M7NP06_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA replication complex GINS protein PSF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_02768</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GINS2/PSF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874798.1">
        <property type="nucleotide sequence ID" value="XM_007876607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP06"/>
    <dbReference type="STRING" id="1069680.M7NP06"/>
    <dbReference type="GeneID" id="19896457"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02768"/>
    <dbReference type="eggNOG" id="KOG4071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078274_1_0_1"/>
    <dbReference type="OMA" id="DSLNCMY"/>
    <dbReference type="OrthoDB" id="1938138at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11712">
        <property type="entry name" value="GINS_A_psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21694">
        <property type="entry name" value="GINS_B_Psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1020:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.5.50:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007257">
        <property type="entry name" value="GINS_Psf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056784">
        <property type="entry name" value="PSF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25005">
        <property type="entry name" value="PSF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028998">
        <property type="entry name" value="GINS_Psf2_subgr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF2 N-terminal" evidence="9">
        <location>
            <begin position="12"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="8">
        <location>
            <begin position="75"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR028998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="195" mass="22219" checksum="75F14B4F70946062" modified="2013-05-29" version="1">MALRPCQIFAFTPSEIAFIAESSPIEIIPRQTMDALPLIGGIIPQFKPPSRVTVPLWMAIFLKRQKRANILPPSWLSQEALEGFLEAEHKVENGFSALPLRWFEISSILLEVASDDLDQPELIRRLLRDLRETRQGKTRDGLASLNETHLQMDNLGSMEINEIRSFFAKSMDQIRRLSALSADNEDLNEMEDQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP64</accession>
    <name>M7NP64_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02679</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874702.1">
        <property type="nucleotide sequence ID" value="XM_007876511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP64"/>
    <dbReference type="STRING" id="1069680.M7NP64"/>
    <dbReference type="GeneID" id="19896370"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02679"/>
    <dbReference type="eggNOG" id="KOG1248">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003753_1_0_1"/>
    <dbReference type="OMA" id="PDQMKHR"/>
    <dbReference type="OrthoDB" id="2192888at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012978">
        <property type="entry name" value="HEAT_RRP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057860">
        <property type="entry name" value="HEAT_RRP12_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052087">
        <property type="entry name" value="RRP12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287:SF1">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25772">
        <property type="entry name" value="HEAT_RRP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08161">
        <property type="entry name" value="RRP12_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRP12 N-terminal HEAT" evidence="6">
        <location>
            <begin position="18"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="RRP12 HEAT" evidence="5">
        <location>
            <begin position="342"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1104"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1128"/>
            <end position="1154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1154" mass="133705" checksum="896998CF25C88528" modified="2013-05-29" version="1">MINKNVLFEEKISRIRSQNGSKNRHQKLIANLLLAIEDTLRNENSQGNITAYFVSLLVLLEQTLPNTNNSELVYSIFYLLDLVIPFISKPLIRSKYAQISSLLSSALRYSGISTSTLRFIISCIQNILIVQENSTWTSPNNNIKSIFSCLLILGLDSRPKIRKRAREAISKILTHPPLSPLIIHPILEFSLRETFNILKKSILELKEGVECKNKKKINYSKAIYSFQLLKTIVDAGGCPASKNEQLCCVLTEILETKNVYLIMIAFDIFLVIFKKCSFTPEKLRGILELMLRKRPSEKDVILLPLWFFVLAAGLESYYQFEPYATFKLLPQLFMDIFPFLRSDSFEIRISCSEILVKLIASCIPNDIGQDNEIVVELTKITMQGFTLNYRVAWKEIFKILIAFFQHLPFYIDPYFMEAIKLIGDMRARDEFNEKIEADKVIGFAVKAIGPKAILEILPLNLDEESKKVPKREWMLAVLRSSIYNTELQHFISEFIPLSEKLYQKLLENNDSEGDKNFKIYIEQIWSLFPSYCNFPLDLEIAFDQDFVQLLLAVFSNQADLRSIICQGLQILINKNKDLIDNDYFDQELKCKFPITKLDAERNLAHLQKFISDILSTLFNVYSQTQSQFREHILLCIKSWLSITNKEEIRNIFNRIIELLSQTLKENSLPNSNKDLASMSYTMLDLLAVMIVYLPDDTSLQLYNIINSQISNETDHILQKKAYNLFSKMTENLSIKVFLENNIEELQKLFLESATKAESSVKKYRFYALYHIINMLPPKDLHFISSILPEVIMGTKETNKKARTMAYNLLILMGNRVLKECTIENNEVLEMNDNVSDIKANIEGFFTMVSSGLLGNSPYMISATIVSITRLLYEFKDVLNLNFISRLLDTVYMFITSNNHEIAKSALGFVKMTIISLPAIIIEERLSMLVSNLMVWVHEHKVHFKVKVKNIIERMIRRYGYETIEKEVPNEDKKLIINIKKTKERHKRKKIAAENISRNPMLNNKHNNFNHKYETYKNEDTDSDISFLINNSDSKNKEISKKETLIKKVDDELIDLLDKNSLINIINMNSKDQKKTEKKKPISMQFKVDNNGKIIIEDLDKNLQKQSNKIQSKRKKESDDDSTDTGNIVKKKSFLNKQKAKSTRNSKRVKRKFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP72</accession>
    <name>M7NP72_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02833</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874868.1">
        <property type="nucleotide sequence ID" value="XM_007876677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP72"/>
    <dbReference type="STRING" id="1069680.M7NP72"/>
    <dbReference type="GeneID" id="19896522"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02833"/>
    <dbReference type="eggNOG" id="KOG3435">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144297_2_0_1"/>
    <dbReference type="OMA" id="FMKWRRK"/>
    <dbReference type="OrthoDB" id="10252718at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013870">
        <property type="entry name" value="Ribosomal_mL54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L54, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08561">
        <property type="entry name" value="Ribosomal_L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="100" mass="11816" checksum="97224A3C94C88537" modified="2013-05-29" version="1">MDLHNKIASKLLIKYKLVIKNISRNFSFKSLAPEGTILKGINIYKKGMDPMALKESEYPDWLWKILDDSKISDEKIEKKKKFKKDNKEKIKSNNFLRSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPC5</accession>
    <name>M7NPC5_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="24">Carbamoyl-phosphate synthase, large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PNEG_02726</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the 2nd section; belongs to the CarB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the 3rd section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the C-terminal section; belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the N-terminal section; belongs to the CarA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874752.1">
        <property type="nucleotide sequence ID" value="XM_007876561.2"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NPC5"/>
    <dbReference type="GeneID" id="19896417"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02726"/>
    <dbReference type="eggNOG" id="KOG0370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000513_2_1_1"/>
    <dbReference type="OMA" id="WSPFNGK"/>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005951">
        <property type="term" value="C:carbamoyl-phosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
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        </source>
    </evidence>
    <sequence length="2213" mass="247776" checksum="DC74C4D0AB404A48" modified="2013-05-29" version="1">MLIRPSSSETPISFDNNPKEVVLELEDGTAYQGYSFGAEKSVSGELVFQTGMVGYPESITDPSYRGQILVLTFPLVGNYGVPSREKVDPLFPDIPLYFESKEIHVSALVVSSYSRTYSHYLSQSSLGDWLQEKGIPAIYGVDTRALTKKIRNQGSMLGRILKIKQDCALYDFSNNDDSWKDKFESVEWVDPNIRNLVKEVSTTSVHIYKPLPEVSQKLSSGEQLRVLCLDVGIKANQIRCFLNRGVELKVVPWNYDFFLENDYHGLFISNGPGDPSILTTVIERLKKCIDAEMTPIFGICLGHQLLARAIGAETMKMKFGNRGQNIPCTNMINGCCYVTSQNHGYAVDASTLPNNWKELYVNINDGSNEGIYHETLPFFSVQFHPESAPGPNDTEFMFDVFIDVIKRSFSEKRLVSFKIPGKILPDNISGFRSCIKKVLILGSGGLSIGQAGEFDYSGSQAIKALKEEGIYTVLINPNIATVQTSKGLADKVYFLPVNPEFVLKVIKYEIPDAIYVTFGGQTSLNVGIRLKDEFEKLGVKVLGTPISTIIMTEDRELFARSMKEINEKCAISASASNIKDAMKVANDIGYPVIVRAAYALGGLGSGFADNATQLYELCSKAFVVSPQVLIEKSMKGWKEIEYEILRDCRDNCIAICNMENFDPLGIHTGDSVVVAPSQTLSNEDYNMLRTTAINVVRHLGVIGECNIQYALNPFLKEYYIVEVNARLSRSSALASKATGFPLAFIAAKLGLGITLDELKNTVTKKTSTCFEPSLDYIVVKIPRWDLKKFTRVNTQLSSSMKSVGEVMSIGRTFEETIQKAIRAIDYNNLGFNETDALMSLDMELQTPSDQRLFAIANAMYAGYSVERIWELTKIDKWFLDRLMGLINFEKKIREYNQYNIPISLLSLAKRFGYSDRQLAKFLGSTELAIRKKRIDASIIPFVKQIDTVSAEFPAYTNYLYMTYNSSEHDISFGDHGVMVLGSGVYRIGSSVEFDWCAVRAIRTVRERGVKTIMVNYNPETVSTDYDEADRLYFENISLERVLDIYDIENSSGVIISMGGQTPNNIALSLHRRNVKILGTSPEMIDSAENRYKFSRMLDRIGIDQPLWKELTSIDEASDFCESVTYPVLVRPSYVLSGAAMNTVYSKDDLANYLKQAVDVSKEHPVVITKYIEGAKEIELDAVAKDGKLIIHFISEHVENAGVHSGDATLILPPQDLDPETVYRIEQATIQIANALNVTGPFNIQFIAKDNEIKVIECNVRAARSWPFVSKVMGVDLVQIATDVILGFSVDPYPIVDISKNYVGVKVPQFSFSRLYGADPVLGVEMASTGEVASFGKDKYEAYLKALVSTGIQLPKKNILLSIGSFKEKTEMLESVIKLHKLGFKLFATAGTADFIYEHGIPVKYLEALPEDEEHQKSEYSLTQHLSKNLIDMYINLPSNNRFRRPANYTSIGYRTRRMAVDYSIPLITNVKCAKLMIEALSRISSIDISPVDFQTSHKSITLPGFIDIAAFIPQITEIDSSTFENITKQYVTSGFTTICIMPIGLNNSVMDARSIPTVILNLKNSTHCDFTFLVVVVPENLNYLDQISGNITSLFIPSSFLSKNISKLASVISNFNTWPNTKVMITDAKGTDLASILLLTSLYDKPIHISNVTTKDDILLISLSKKKGLKVTCDVSIYSLFLSQSDIHESKALPTEVDQKSLWENMQIIDCFSVGCLPYQVAYELNQAHCFHVGISESLSLLFTAITDKRLTLDDILLRLYYNPKHIFGIPDQADTFIEVEIDRSYVLNLVDGWSPFIGQKMVGSIHRVVFNGQTSYLDGKFFPNYKGKDISMTFNSSSLSLTDVSLISLKKDTDLKPFVSSSRSLNERNSPLIYSEQFKKTSLSFVSQISDAGTLFSLIRNTNFFRKNIISVQQFNRRDMHLLFSIAHEMRIAVERQGILNLLASKVLCMIFFEPSTRTSASFNAAMQRLGGRVISINVSTSSVKKGESLADTIRTLGCYGDAIVLRHPSEDSASIASKFSPVPIINGGNGSYEHPTQAFLDLYTIREELGTVNGLNITFLGDLKYGRTVHSLVRLLRFYQVEINLVSPPQLALPKDIKRSILDQDQIVNEYFALTEEIISTTDVLYCTRVQGERFSDPEEYERLKNSFTINNDVLHKAKPQMIIMHPLPRNKEISEEVDFDQRAAYFREVKYGMFIRMALLVAVLGINERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPP7</accession>
    <name>M7NPP7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874576.1">
        <property type="nucleotide sequence ID" value="XM_007876385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPP7"/>
    <dbReference type="STRING" id="1069680.M7NPP7"/>
    <dbReference type="GeneID" id="19896255"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02563"/>
    <dbReference type="eggNOG" id="ENOG502R7J1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_283307_0_0_1"/>
    <dbReference type="OrthoDB" id="4066896at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057454">
        <property type="entry name" value="Bud3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032634">
        <property type="entry name" value="Gef2/Nod1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF159">
        <property type="entry name" value="LD03170P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17114">
        <property type="entry name" value="Nod1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25351">
        <property type="entry name" value="PH_BUD3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="1">
        <location>
            <begin position="251"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1171" mass="134506" checksum="B3E07D9E2F293C17" modified="2013-05-29" version="1">MKNNSKETRENDEKTLIRENENIMYDFSGGDSTIFWRNMTYEDMLDVDSFFKKNQIHYITDDPVVGLVLISVAVDKFNMIHAHVFTCCGPLSLPLISPKNQEALSIVISHLPHTSRSQSFQVIAMVILQYFIFIPLHIKKEVLRQYNYLRSNEDQERRIAFDEMHAGDIAGHCKLLKLSDISSILCSILKRRKIVSFNIDIILPDNSKSTPLFSKLQEMTSNEEKSGELPFENKKIVPGPMTDNYKEHDKKRLSILNEILQTEQNYIERLRHLVLDYVLPLRTQAKSSKNPPLGLYDINRIFPVSLNDIISLNSAFLQDFIQAKTEIEKANSFVTHFYRFKKTYAKYLELSVDFESLLRHNLRNPKFRNFVDNQKYKAEKNISIRELIMEPVQRIPRYSLFLENVISYTHPKSPALALFQKALTIIKEIAQMKVMEAEKRSKLFQKLMSYISGFPAELISNSRYFITAVDVIEILPPFLNSSGRLFYTLLLFSDCLAMLKKTSHIPVAKDLISNEDNSSFHRFRSRQNSFGFTTSVSRKDILFQCWANLDDLEIDIDENDDTNMWITVQAPVNSCTDKELWGSFSEHKMSIMSESKHCVIGFVEKFYRTKAKNKTSKNFIAEIEKSNINIICNVFEASEYKKERKKSEIAIQYVQQSLINAFERKFPKINISGLFLIEESSGIYRLDFHSPLSWKLSPQKFQYLDMLLENIFQKAILFHNFLKSWDSPKNVPFFISKYRFLLSCLFKLNSTSSSTKTIFPSITYFNSSNNHTSSILENSQLPPRDLAASLSHSNSLPKTFIKKSFLSFSLTKLNSENCISKFKNNGSSSLEIIKDRHIFHGAETFVHTLCSIEDFDSISTLTYSNSELKNAIELSNEIAKNPEKNYAILGSPLKIGYAAFKHYMKTHVNKKIGPILPQEFIKSCLNIIGEPDSIDEKISKIHDITLVLPQGNYVILYLVIYLTLHILNKTHGEVLKVLLSIVSEGIVPKNDVSVLIPILKFMTQNFSQVFYEFAKNNSASTLTTNNMPSTFFRNSNQSETTSSSFTNSLYDELFILPDTYTSAFSNVNNKDIAPLPLKNSLSLNCVQKKTSKKVLRKNTTSELSVGTTIPQTKSSNMTDSNIYQEYGKAYFSNSNKKYIKTCDNIEKKDDFLIVPSNFKISSTQCVNNQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPP9</accession>
    <name>M7NPP9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_00834</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872743.1">
        <property type="nucleotide sequence ID" value="XM_007874552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPP9"/>
    <dbReference type="STRING" id="1069680.M7NPP9"/>
    <dbReference type="GeneID" id="19894532"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00834"/>
    <dbReference type="eggNOG" id="KOG1164">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019279_2_0_1"/>
    <dbReference type="OMA" id="IFDWTFL"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14125">
        <property type="entry name" value="STKc_CK1_delta_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000159">
        <property type="entry name" value="Casein kinase I hhp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="11"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="345"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR10683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="431" mass="49222" checksum="9F13B7F3E9ED841C" modified="2013-05-29" version="1">MAMDLRVGNKYRIGRKIGSGSFGDIYLGTNIISGEEIAIKLESSKVKHPQLEYEARVYKALAGGVGIPFVRWFGTECDYNAMVMDLLGPSLEDLFNFCNRKFSLKTVLLLADQLISRIEYIHAKSFIHRDIKPDNFLMGIGKRGNQVNVIDFGLAKKFRDPKTHLHIPYRENKNLTGTARYASINTHLGVEQSRRDDLESLGYVMMYFCRGSLPWQGLKAATKKQKYDRIMEKKMTTPTEVLTRGFPNEFAIYLNYTRSLRFDDKPDYSYLRKLFRDLFVREGFHYDYVFDWTIFKYNQTKQTQTITQTQQEEGGVHVLDDQNTNFQKTRNANTIAQTSATNGMQSSVFPSRLGGNSGSMNTSRRKIQPQTNEATLSIAPIDFSRTTNVSGSDRMLRSQAKNGSSGYTINNSCKIKREEGQHVSTSQTGWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPW6</accession>
    <name>M7NPW6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PH-response regulator protein palI/RIM9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00897</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872808.1">
        <property type="nucleotide sequence ID" value="XM_007874617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPW6"/>
    <dbReference type="STRING" id="1069680.M7NPW6"/>
    <dbReference type="GeneID" id="19894595"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00897"/>
    <dbReference type="eggNOG" id="ENOG502QVGD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_412840_0_0_1"/>
    <dbReference type="OrthoDB" id="2354757at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF3">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="334"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="583"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="351"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="599"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="665" mass="76945" checksum="5ECEA10BF2A960D0" modified="2013-05-29" version="1">MSRTITFATLSLIPAWILLLLSCLSVPITRFISLGSLNDLHFGVFGYCFAKGKCNVAQLGYRMDIAISSKSKHTSDFYFSFYKVQGLTYIFIVHIVSASLTFCAFVFTLIAHLEGPSKSDFFLVIILIITFFTVFFSIVSFIVDVLFFIPHLEWGTWGILASSILNIIVFGLIHLSRKYLIACRSEKVKTAFSYHSQRRHPNLSYPYANNLPFPKHTVYQTKKDGKDRTEKDKSTLDSIKYPKNDNDIKHTSKLKKLELPPINTHLDDHNMLSKSFLDSTYCNSSTYDSTIPNKNVNITYNEAYKDDNRVHESYLKQEGSIHERMGYPEDYSKDYLRHHPREHPRNHLRYHSADIPRDPPKNHPRDPLKDIPKDYPRGHARYHSSYVSRHHLREQPMDVPREYLRNPPREYMRNPRDIPKEHLRNYPREQITMQPHFRQGADNRNMQYPVCKPPVGLGIEYRRNPKRPVDLVEKGKPNNNYNNSYGDYAPPRQTWKDYPLQQNGRAFSQDSNDGVHNFSSCKPCVSDKLYENKFAEHGPVSQNYAYNSHPYSEDVEHRFSNNADCSSHTTDQYSRMHLPYRSNNSAQTQESLSPRFKSPASTSSEFTSISQRGINPKWVPPSKEQMPRVGKFKQNNLDATLVNNLNYDLPKNPYKEIGVVGSAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ39</accession>
    <name>M7NQ39_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872873.1">
        <property type="nucleotide sequence ID" value="XM_007874682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ39"/>
    <dbReference type="STRING" id="1069680.M7NQ39"/>
    <dbReference type="GeneID" id="19894658"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00960"/>
    <dbReference type="eggNOG" id="KOG1092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018687_6_0_1"/>
    <dbReference type="OMA" id="SCYNIFN"/>
    <dbReference type="OrthoDB" id="26371at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000007">
        <property type="entry name" value="TBC1 domain family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000037">
        <property type="entry name" value="TBC1 domain family member 22A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000001">
        <property type="entry name" value="TBC1 domain family member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF26">
        <property type="entry name" value="LD44506P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="199"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="493" mass="57838" checksum="DFB3BF8BF2AE9489" modified="2013-05-29" version="1">MGFVFLRDEKGSSNENLRSEKNGKKHSNTKEESYPHIGISKTQKSLLSSKSLYNFQSKGIMPLASLYKGNSSSFSDYVSQTDDDWGINIEDEKEFLQLFKTKNELSQLSIYDKISNTYEKPFNLNEEKKELESKLPKNKEITDIHNFLSFKGQYPPLEKKCDIGNKNTDFYIVKVERFSQILQETSIDLNTLRKYAWNGIPDEFRPIVWKLLMGYLPCNASRREATLSRKRNEYLKSVSQTYEKGIKELDQAIWHQIHIDVLRTNPTIKLYQYETTQKCLEKILYVWVIRHPASGYVQGINDLVTPFFQVFLSEYIDGDPEIYDPSDLPKDTLDIIEADTFWCISKLLDSIQDNYVFAQPGIHRQIINLKELITRIDHQLSNHLEKEGVEYIQFSFRWMNCMLMREMSVKNTIRMWDTYMAEGQSGFSDFHVYVCAAFLVKWSPQLLKMDFQEIIIFLQSLPTQHWTYKDIEILLSEAFLWKSLFSGAKAHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQB2</accession>
    <name>M7NQB2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01049</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872962.1">
        <property type="nucleotide sequence ID" value="XM_007874771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQB2"/>
    <dbReference type="STRING" id="1069680.M7NQB2"/>
    <dbReference type="GeneID" id="19894747"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01049"/>
    <dbReference type="eggNOG" id="ENOG502QRI8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029881_1_1_1"/>
    <dbReference type="OMA" id="WAPIREP"/>
    <dbReference type="OrthoDB" id="5584247at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052246">
        <property type="entry name" value="Cell_Polariz_PKAAnc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155:SF1">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155">
        <property type="entry name" value="A-KINASE ANCHOR PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="152"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="351" mass="40411" checksum="3500BF6C96CE7D16" modified="2013-05-29" version="1">MSFKDSRDRLPTLHEVLSRRAEPPVDLFNFYIYMRDQAQSVDYLDLWLDIMQHTSLCRLYVRELRKSILVSTPEKFDKEAKEKLKNFKDGEEGDYLRSTMYSEKDIDVHIVTSNLHNFGPLGSELNNNRTSGNKGRKRESYLSSEESRNSSEVTQTINRKDIRASAERVLYAYLIQGAEREVALPSHILRGIATAIEADGRDDPEVFDEARDYVFQAMERDAYPGFLRAKALGNIIPLSSLLRLLIGLLSLFAGLWTGFTLIFLGATKSERSWIFLPFLIGIYCIYAHQYFLDPILVIIGLSETTFLSYMRIREPYVKKLLLKRALWVLLLIGITVITISLLMSLVPTYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQK6</accession>
    <name>M7NQK6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trafficking protein particle complex II-specific subunit 65 IgD3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874119.1">
        <property type="nucleotide sequence ID" value="XM_007875928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQK6"/>
    <dbReference type="STRING" id="1069680.M7NQK6"/>
    <dbReference type="GeneID" id="19895831"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02138"/>
    <dbReference type="eggNOG" id="ENOG502RYDF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_497922_0_0_1"/>
    <dbReference type="OMA" id="NPRITEC"/>
    <dbReference type="OrthoDB" id="5345392at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055420">
        <property type="entry name" value="IgD3_Trs65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024662">
        <property type="entry name" value="Trs65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159:SF1">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12735">
        <property type="entry name" value="IgD3_Trs65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex II-specific subunit 65 IgD3" evidence="1">
        <location>
            <begin position="398"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="547" mass="62466" checksum="2291D5EFBC9AF4A4" modified="2013-05-29" version="1">MIEEIGFFFTKTMLDIIIVAQDLSLDNGVEAILSAPRRRLLFHDEITKVFIVLTCQNDFLKLQHMKLASYLSCTVNGWIGDVQKYGSHVSSKEEENSGKEHPNEGVNFFFSVLNSQKMIFEWNDGHAVIIWGTEIQIPFPRIRTSIPKVQLIVSITVKPEALVMFNEEEGIKRDYMSINVLESLSSETMVYGVTPFLSMSRVSNISIASNTDLSSSTQILRKVIRRVFSCRSAISLRTRSSMTMIPNFQRILLGIDIESCFLKQLSVLIEDIEIKVKGQIAQKIENETKFPITLSFQEQFFMLYYIPFDPSIDQGITDLLTLPVTIFVKMRPRLLDTNYTLLLMSQWHTTIHISKDQTQVSLYRSVIHTEAKTLNSSLFLQKSLINTNNNLSKSRSPSLSNTKSPFLNISFTFTAPKYVRIWKIFEVKIALVNQSTVSKDIFLSVLSKAHDIDYNNLPFISEKDSCFLLEENAIYTLHKHISVNPVHVLPLVNNIHIGPLDSYGCYFCSISFIAIREGLFSFDGIRIHDIKTGSYIDCYSLPNIFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQY6</accession>
    <name>M7NQY6_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873828.1">
        <property type="nucleotide sequence ID" value="XM_007875637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQY6"/>
    <dbReference type="STRING" id="1069680.M7NQY6"/>
    <dbReference type="GeneID" id="19895551"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01857"/>
    <dbReference type="HOGENOM" id="CLU_2400619_0_0_1"/>
    <dbReference type="OrthoDB" id="5555533at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037652">
        <property type="entry name" value="Mim2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28230">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28230:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19117">
        <property type="entry name" value="Mim2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="93" mass="10831" checksum="21BAE33EE11795E1" modified="2013-05-29" version="1">MVKNAELYPLNIPSDISDSLSTISSDTDKEWQESISQLNIFLFWIIIPFIGKWAGRQFAYFLWERCIKMKTPIELSIKSQGVLGLRKLLTPFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M7NR16</accession>
    <name>M7NR16_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873858.1">
        <property type="nucleotide sequence ID" value="XM_007875667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NR16"/>
    <dbReference type="GeneID" id="19895578"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01884"/>
    <dbReference type="eggNOG" id="ENOG502S6F0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1482599_0_0_1"/>
    <dbReference type="OMA" id="EWCIARR"/>
    <dbReference type="OrthoDB" id="21418at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029196">
        <property type="entry name" value="HAPSTR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645:SF1">
        <property type="entry name" value="YALI0F12243P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15251">
        <property type="entry name" value="TAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="182" mass="20926" checksum="8D1AEAB1C3B446E3" modified="2013-05-29" version="1">MDMSSLHNHLPDKRKETKNEQDDLLSTFKAAALSVTNLYRQALTTAGQERQEGFQDAVEEMLMLLNDGITDIESLREWCIARRRNEENSYSSSDLSEESNHNTSRTNSLDLNFSKSTLSSSPTPQYFQNNLTERAETLYSSNNPSNDENLSFQFIDSPRLSTKHRIIFNDSKSVFSKKCRHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NR21</accession>
    <name>M7NR21_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA recombination and repair protein Rad51-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01889</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873863.1">
        <property type="nucleotide sequence ID" value="XM_007875672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NR21"/>
    <dbReference type="STRING" id="1069680.M7NR21"/>
    <dbReference type="GeneID" id="19895583"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01889"/>
    <dbReference type="eggNOG" id="KOG2859">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060999_1_0_1"/>
    <dbReference type="OrthoDB" id="420422at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19490">
        <property type="entry name" value="XRCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030547">
        <property type="entry name" value="XRCC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46644">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46644:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR09702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="42804" checksum="E382BF0A6C1C8173" modified="2013-05-29" version="1">METIVSVKEIFNTFEYESCTDLLETIRSHLCYKKGGVKFCINLLDDLIASKNDKGLQYGDILEFQGPYGSGKRHLLYFIASTTLLPKVYESNDKKEVIGGLEEGIVLLDCSRKWQTFRLEEIMYEKIKNIFKKNQNNTINEKDDAESKNKIIKNIIKESLSRLYIFRPENSISLIATLKYLPHYFKSYANDLKIRYVFLDSISAFYWKDRYSDLLSNSSLQEQINIIYKRITQLLKKFCYTWCSLAISTNWVLQVSQNFNPYTTDIRYFTISEDSFQIYHHHLPLSYTSQVSHRICFLRKAVAQFSPGIDLENLLIYSQQRNNILQLGLYLAVLQRLSNKDLAPSKRTGFIFRITKDNVQIEKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M7NR33</accession>
    <name>M7NR33_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_02157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874138.1">
        <property type="nucleotide sequence ID" value="XM_007875947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NR33"/>
    <dbReference type="GeneID" id="19895850"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02157"/>
    <dbReference type="HOGENOM" id="CLU_1865971_0_0_1"/>
    <dbReference type="OrthoDB" id="5385626at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR09571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="137" mass="16950" checksum="D839483DCA1A5260" modified="2013-05-29" version="1">MNCECSKKFTSILFMKGYEQCKIYNGQMFYCFSCGSKDSFRSLHNQRLQMYLDRVRHCREEYWLKNRKKDQIMQSFFLAEENERRKFLEQEAIFHQITFDEIDDDEHIFIDQIEALEDEQNNYLIDRYVKDTFEERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NR97</accession>
    <name>M7NR97_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01941</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat LST8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873918.1">
        <property type="nucleotide sequence ID" value="XM_007875727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NR97"/>
    <dbReference type="STRING" id="1069680.M7NR97"/>
    <dbReference type="GeneID" id="19895635"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01941"/>
    <dbReference type="eggNOG" id="ENOG502RZG9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_429036_0_0_1"/>
    <dbReference type="OMA" id="TKMIHFD"/>
    <dbReference type="OrthoDB" id="10248252at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF2">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G04300)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="297"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="552"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="627" mass="71518" checksum="9AA1658C55705150" modified="2013-05-29" version="1">MDNKVYFKHNDSTSFPEEMYFYDFFDEYYYNNILIPTQQKIITNEKDYIGNGSLNEETTSEYEKEAYDIHLELVIPCKNDQNLCRPYLSKKARQFLRHTGQWEELTKLENHIIHVDFTGYEAFMLSRLLFFLNDEQITERINSFLPGRTFDDCKRFLSDNPNCKAHNCPIAIKVLMKGPEKSVQDDRVVKSNWITLFLQRQCGGWIHPRYSKNISNHINSKIIQLLKPYKFFDRTSGDVVDLTFDPLGKKFAFGCSTTQDDYNREGNLVICDIDSEIATVLTDHKIIVNENVFYPTVSNVKFSADGLFLFSGAFDSTIKVWSRSGHLLNSFKDLNGKIDVMVSHPLNPKILSASSHDGNIHLYRLNENGLCASYAKLGTINHNLYGSAMAFGNHLLNHLLLVGYENIDESKYLGTAVVFDIMTETFLKELKTENTSHTSIFAHNFSDYFVTGSNTCKDGKVRVYTAKDWSIIIECYSSQKDINQVTLSPCLRYLTSSATDRSTYVWDTRKSDIPLHILHHDQTKMFYSDDENIEDLDSGTTVSLWGSYAHEFITGGSDGYLKLWDLGNNQPFVQNLIEVNSAITSACISPDHDLFIIGESIGHVTVLSTKGTGLPSCFNINIQSSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRH4</accession>
    <name>M7NRH4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="5">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00362</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="5"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872235.1">
        <property type="nucleotide sequence ID" value="XM_007874044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRH4"/>
    <dbReference type="STRING" id="1069680.M7NRH4"/>
    <dbReference type="GeneID" id="19894060"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00362"/>
    <dbReference type="eggNOG" id="KOG0856">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_8_1_1"/>
    <dbReference type="OMA" id="YDETTDW"/>
    <dbReference type="OrthoDB" id="44061at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00357">
        <property type="entry name" value="peptide-methionine (R)-S-oxide reductase MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081:SF8">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="6">
        <location>
            <begin position="9"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="135" mass="15401" checksum="7A4E1CA35594D2DB" modified="2013-05-29" version="1">MAFPIKKSPEEWKRILCPDRYKILRKKNTEPPGSGEYDSHYPLYGFYICAGCKFPLYKAETKFKSGCGWPSFYQSIENSVKRIPDLSGGRIRTEIVCSQCGGHLGHVFKGEGFNVPTDERHCVNSLSILYKNIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRI7</accession>
    <name>M7NRI7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">OPA3-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00377</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872250.1">
        <property type="nucleotide sequence ID" value="XM_007874059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRI7"/>
    <dbReference type="STRING" id="1069680.M7NRI7"/>
    <dbReference type="GeneID" id="19894075"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00377"/>
    <dbReference type="eggNOG" id="KOG3335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074707_3_2_1"/>
    <dbReference type="OMA" id="WAEFEGT"/>
    <dbReference type="OrthoDB" id="2129069at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010754">
        <property type="entry name" value="OPA3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499:SF0">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07047">
        <property type="entry name" value="OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="102"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR11348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="16038" checksum="E429906887A5F286" modified="2013-05-29" version="1">MSLALKIGFLVIKTLSKPIATNLKRQAKQYPYFRKICVDLAQVMHRTESHMKANLLGKRKKTKHTQCLNEENAIERGADFLSESFLFLTAGSLIFYESWKTRKKEQTRRDKVADDIEELQKQLASLKKYIEETVLSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRJ1</accession>
    <name>M7NRJ1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01916</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 33 different proteins. The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and at least 46 different proteins. eL19 lies in close proximity to the binding site for eukaryotic initiation factor eIF4G.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873892.1">
        <property type="nucleotide sequence ID" value="XM_007875701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRJ1"/>
    <dbReference type="STRING" id="1069680.M7NRJ1"/>
    <dbReference type="GeneID" id="19895610"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01916"/>
    <dbReference type="eggNOG" id="KOG1696">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083919_0_1_1"/>
    <dbReference type="OMA" id="NRVWIDP"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01417">
        <property type="entry name" value="Ribosomal_L19e_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.240:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1650.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01475">
        <property type="entry name" value="Ribosomal_eL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_eL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="Ribosomal_eL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023638">
        <property type="entry name" value="Ribosomal_eL19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_eL19_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_eL19_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033935">
        <property type="entry name" value="Ribosomal_eL19_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057259">
        <property type="entry name" value="Ribosomal_L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057260">
        <property type="entry name" value="Ribosomal_L19e_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006343">
        <property type="entry name" value="PRK08570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25476">
        <property type="entry name" value="Ribosomal_L19e_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="Ribosomal protein L19 (L19e)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00526">
        <property type="entry name" value="RIBOSOMAL_L19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL19" evidence="7">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="144"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00063679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="190" mass="22301" checksum="91D3ABA6049B75A7" modified="2013-05-29" version="1">MVNLKSQKRLAAAVLGCGKRKIWIDPNEISEISNANSRQNIRRLIKDGLIIRKPPVIHSRFRVRLLHASKSKGRHMGPGKRKGTANARCSSKFQWQCRLRVLRRLLRRYRDDGKIDKCLYHTLYAKAKGNQFKHKRALVEYIHREKAEAARSNLIQQQMEARRAKAKAARERRTLRIIEKRNEFLKADEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRS6</accession>
    <name>M7NRS6_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873952.1">
        <property type="nucleotide sequence ID" value="XM_007875761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRS6"/>
    <dbReference type="GeneID" id="19895668"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01974"/>
    <dbReference type="HOGENOM" id="CLU_1415709_0_0_1"/>
    <dbReference type="OrthoDB" id="5399341at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR09791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="192" mass="23325" checksum="05DD1350F76CA3DB" modified="2013-05-29" version="1">MKIVLWKESEKSCDLQDKSNKKKWIKNMIWHKQNRDIRNENTISSDRIGLYRHSFFGFSRKFLKKTFFLRNKIIDPFFDDISEDIIVSDSFKRKDMSLWSRKISPDFLFYLLTLKQKDFGRILLNLYYLNENIKKNPLFLSKEAYCNSMESIKISQRSKLYILKQLFYTFNYYSKLWLTVYIPKTELILGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRZ0</accession>
    <name>M7NRZ0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit I</fullName>
            <shortName evidence="7">eIF3i</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 39 kDa subunit homolog</fullName>
            <shortName evidence="7">eIF-3 39 kDa subunit homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TIF34</name>
        <name evidence="9" type="ORF">PNEG_01801</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873769.1">
        <property type="nucleotide sequence ID" value="XM_007875578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRZ0"/>
    <dbReference type="STRING" id="1069680.M7NRZ0"/>
    <dbReference type="GeneID" id="19895495"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01801"/>
    <dbReference type="eggNOG" id="KOG0643">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043845_0_1_1"/>
    <dbReference type="OMA" id="VWFSHNG"/>
    <dbReference type="OrthoDB" id="24966at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000127">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03008">
        <property type="entry name" value="eIF3i"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027525">
        <property type="entry name" value="eIF3i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF1">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24805">
        <property type="entry name" value="EIF3I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="6"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="48"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="187"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="328" mass="36658" checksum="24851038F02F2DA4" modified="2013-05-29" version="1">MRPILLQGHERPLTQVKFNDDGDLLFSVSKDHIINVWFSHNGERLGTYHGHQGAIWSVDVNSTSTLMASGSADNTIMLWDVKTGKSLKVWKFPTAVKRVEFNEDNSLLLGVTEQRMGHIGSLVVFSIINDVDAEQANAPIYTILTQDSKATVAGWSYLSNYIITGHENGSVSCYDAKAGKHIRTEQIHEKGQPVTDLQFSPDRTYFITSSKDKTAKICDVESLKVLKTYITDTPLNTAAITPIKNFVILGGGQEARDVTTTSQRQGKFEAKFFHKIFEEEIGRIKGHFGPLNTIAVHPKGIAYASGSEDGYTRIHHFPQNYFDFEYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NS01</accession>
    <name>M7NS01_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00543</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872434.1">
        <property type="nucleotide sequence ID" value="XM_007874243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NS01"/>
    <dbReference type="STRING" id="1069680.M7NS01"/>
    <dbReference type="GeneID" id="19894241"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00543"/>
    <dbReference type="eggNOG" id="KOG0759">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2455666_0_0_1"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="89" mass="10300" checksum="BAB71D3C8CA31A08" modified="2013-05-29" version="1">MYNGLTTNILRQETYSTVHFGIYYELKSTVSERIWKSLTFSTLICIATISEAIGGVISNPMDIINIRMQNDNSSLYKEEIKRTYSMDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NS29</accession>
    <name>M7NS29_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA replication factor Cdt1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01836</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cdt1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873809.1">
        <property type="nucleotide sequence ID" value="XM_007875618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NS29"/>
    <dbReference type="STRING" id="1069680.M7NS29"/>
    <dbReference type="GeneID" id="19895530"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01836"/>
    <dbReference type="eggNOG" id="ENOG502T0YJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_826728_0_0_1"/>
    <dbReference type="OMA" id="CIDMVQL"/>
    <dbReference type="OrthoDB" id="341730at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1420">
        <property type="entry name" value="DNA replication factor Cdt1, C-terminal WH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032054">
        <property type="entry name" value="Cdt1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038090">
        <property type="entry name" value="Cdt1_C_WH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16679">
        <property type="entry name" value="CDT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Cdt1 C-terminal" evidence="3">
        <location>
            <begin position="215"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="336" mass="38563" checksum="2C773757D6EE8851" modified="2013-05-29" version="1">MSRPIYAFLPSRKSTSIKRKRLLEPELANKRINVDQNHKIRVPIKNQNENVHQQDTSIIKIFSALDQALVYHHAISYGEGTASFHYLQHSLETQAKKSFTLESLERIVSIWPESFKISPTIILFNGKRIGSLSIDFPTKEFNLAARLKQFRSRLELSQSITTDLKKIIPKNVSSNTIICLPEKKKQAIQELEKKTTSTSDTSIDSNKSLKYRQTSLLERIRFKHTRNTHTSPAFEQLNSLQKLSNIVECLFVLLATYPRKSAFSMSEVVTVLTSSLKHPLSITEIHKLLAVLVNTLPKFCQIIKISDTLSAIKFYRNYKLAEIKKIIELKQIELQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NS49</accession>
    <name>M7NS49_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UBR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00027</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871878.1">
        <property type="nucleotide sequence ID" value="XM_007873687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NS49"/>
    <dbReference type="STRING" id="1069680.M7NS49"/>
    <dbReference type="GeneID" id="19893725"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00027"/>
    <dbReference type="eggNOG" id="KOG2752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025221_1_0_1"/>
    <dbReference type="OMA" id="GAMVYNH"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15542">
        <property type="entry name" value="PHD_UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19677">
        <property type="entry name" value="UBR-box_UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040204">
        <property type="entry name" value="UBR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047506">
        <property type="entry name" value="UBR7-like_UBR-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="7">
        <location>
            <begin position="45"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="133"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="5">
        <location>
            <begin position="45"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR11583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="46444" checksum="5C1DA33F51239F3C" modified="2013-05-29" version="1">MVGKEIDRKTDQESHVGSEMSLIDYIEEQSHLEEEARESLPYNFDHCTYDRRLRQPLYVCKTCFPVNGERQKGGICYSCSIQCHGDHELIELFCKRDFRCDCGTDRLGTEICKIRKEHSPVDPDNQYNHNFEGKFCWCDADYDPATDERTMFQCLLCEDWFHDQCIGMENIKNSDDYDFFICRSCVKKESWLKRYLHVKGFVCNKKNEPSYQNERKNILNTASTANEEIPVLNSDKNMKRKLNDDEFLELSPKRLKTENNIQQSCSWAILPMGPKEDVSLFLSNDFRLGICHCVQCLALMAKNPVLLAEEETYEPPEDSDDESLIDAGVRALNSLPRVQAIEGIIAYNYMKDALSKFLRPYAEEGKVVTEDAIREFFDKQMEEKKMSNMLSKTYKDTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSR1</accession>
    <name>M7NSR1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01558</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fmt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873507.1">
        <property type="nucleotide sequence ID" value="XM_007875316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSR1"/>
    <dbReference type="STRING" id="1069680.M7NSR1"/>
    <dbReference type="GeneID" id="19895253"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01558"/>
    <dbReference type="eggNOG" id="KOG3082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033347_0_0_1"/>
    <dbReference type="OMA" id="KEWWNGV"/>
    <dbReference type="OrthoDB" id="10268103at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138:SF5">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="5">
        <location>
            <begin position="31"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl transferase C-terminal" evidence="6">
        <location>
            <begin position="243"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="352" mass="41081" checksum="4B2E8894702FCEBF" modified="2013-05-29" version="1">MLFYAFLKILKKTYQRRYFTESIYLKREPLRILFFGNDNFSTFSLLSLISLFQSNKTILEKLEVATLSDMKIGRRHKILYKTPVKLLALEHDLKIHEIENGNMEKINNIIYDDREMFNLAITASFGHLIPSSFLKNLKFGGINIHPSLLPRYKGPAPLHHTLLNRDKYTGVTIQTLYPDKFDEGRIISISELYEIEKHETLESLSEKLSKIGANLLIQVLLKQEYLNINMNIQNLYEPSYAKKMNKENQVIKWNIWDSDEIELRSRIFGKLKCKFKSSNKTVILSNIQIINDTEERIYGCPGLYTYSKDGLFVRCLDGRNLKIGKIKIEGKNWIDGKEWSKTCLKGKNGYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NST2</accession>
    <name>M7NST2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kinetochore protein Mis14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872098.1">
        <property type="nucleotide sequence ID" value="XM_007873907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NST2"/>
    <dbReference type="STRING" id="1069680.M7NST2"/>
    <dbReference type="GeneID" id="19893927"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00229"/>
    <dbReference type="eggNOG" id="ENOG502SA1D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1240755_0_0_1"/>
    <dbReference type="OMA" id="EVQRNWE"/>
    <dbReference type="OrthoDB" id="2135762at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013950">
        <property type="entry name" value="Mis14/Nsl1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31749">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN NSL1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31749:SF3">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN NSL1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08641">
        <property type="entry name" value="Mis14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="24289" checksum="7EE5CCD737B880BF" modified="2013-05-29" version="1">MSFEYDKSLSKISLDSAADLKYLSINFAKTIEEKLQKHMPKNVSNNSKDILREKVENLLENFITRTFELAKPNIIINGIEAQETIIEDSSTILEPFNYDLNNKLQSLHNEIEETILKTTQLRREIPRKIFEYKNSQNIAEIKINFPEEPLMKTIKTEHIIEPELPRENEIKQEYSDAISAMKQLKTSIPTTCAKLEKSIEIIKHFYEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTA2</accession>
    <name>M7NTA2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RRN6 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873511.1">
        <property type="nucleotide sequence ID" value="XM_007875320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTA2"/>
    <dbReference type="STRING" id="1069680.M7NTA2"/>
    <dbReference type="GeneID" id="19895256"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01561"/>
    <dbReference type="eggNOG" id="ENOG502RS0C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_353773_0_0_1"/>
    <dbReference type="OMA" id="GRYRTIE"/>
    <dbReference type="OrthoDB" id="4090074at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001179">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001163">
        <property type="term" value="F:RNA polymerase I transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019350">
        <property type="entry name" value="RNA_pol_I-sp_TIF_RRN6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048535">
        <property type="entry name" value="RRN6_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221:SF2">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10214">
        <property type="entry name" value="Rrn6_beta-prop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRN6 beta-propeller" evidence="1">
        <location>
            <begin position="129"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="794" mass="92809" checksum="6E33A888DB19AABC" modified="2013-05-29" version="1">MSNWPLSASETHISLSYGSLGAALYSPENIKSKWSFVKNKLGPHLKALGENMLEYDGSMFFLEESLIQPSRTMQEKYLRANYPDIWVPQDILKPWIKESNIITSTYILHDPLRGKCLTECQFWNPESRNISSKMLGFVSGVNSMNLSLATIKNHNTTIYCRDDIKKSLKVPKISEIIDSVFTSQTPIRQISGNSINNSRHLLIRNHTSSTLFELIHNPSEQTSIKNTYINSIPLVIIENNDTGNCEHSDVIFDFFNKRELVVINRKGQWSLWDIEGRYRTIEQSSSNILTNIKETDGWWKIDWASSPRSIIVSGRYEVKLFDLRIPSNQNSLYSLQSSQNILDFCKISQNSNDFFILSTSEIYWLDERQPEKPLLSWKHYRSYDPSLKFIIDDSIRNFNLILYSNINPIKSCYQFELKGSLAFSSTLPYELPNSRSTSMTSIICPLNKHDNKFRKKDLDDHFFLKLYSLVSKKNIISQIYYYADDDINYTFCNHKSLHSVKKSNKYIDNSSENESIEENKEMERSIFERDFRLVDFSNLYNQITHINDFVFRKFLLESQNKKGKPSENCEILILRDIYAPSKETNFDEIFLYLKKIFQDYIENGWEIYSLIPKSQKLLGIIDFDLESDNWNFKNIYDTLIKHWLDTYDQNNSPKYHREHIYKLFKDISIELGISSIGLKPPESFIKSKRKSLNNCLFDDNFEIIQNDIISEDISSLLDEWKIGINPNLYEWQPFNKTSINTEFLYEQISSAPPKLMSTPSLLTIQTSEKNDLTDQKSLSQPFKKIKTKQRRAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTU6</accession>
    <name>M7NTU6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01244</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873165.1">
        <property type="nucleotide sequence ID" value="XM_007874974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTU6"/>
    <dbReference type="STRING" id="1069680.M7NTU6"/>
    <dbReference type="GeneID" id="19894941"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01244"/>
    <dbReference type="eggNOG" id="KOG1973">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074406_1_0_1"/>
    <dbReference type="OMA" id="MIACDAF"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="10">
        <location>
            <begin position="125"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="72"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR10536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="182" mass="21088" checksum="081D0D6A342AE844" modified="2013-05-29" version="1">MIVTQHLPVDLLRSLQLIRQLDDESSICINQLDELALTVSTAEPEKYVQMARLLKISTQNRSIALTETCRLHKTVERHLDAIEQTLQSLQEALVENQQVKELEIINKEKLKTKKKHRNISKEPRYCFCNQISYGRMIACDNDKCKREWFHWDCVSITSVPKGKWTCSDECASSIGLKKKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTX4</accession>
    <name>M7NTX4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 8">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="1 8">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 8">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00867</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="1 8"/>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872777.1">
        <property type="nucleotide sequence ID" value="XM_007874586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTX4"/>
    <dbReference type="STRING" id="1069680.M7NTX4"/>
    <dbReference type="GeneID" id="19894565"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00867"/>
    <dbReference type="eggNOG" id="KOG1885">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008255_6_0_1"/>
    <dbReference type="OMA" id="MQERHVD"/>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070154">
        <property type="term" value="P:mitochondrial lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF5">
        <property type="entry name" value="LYSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="9">
        <location>
            <begin position="216"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR10717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="554" mass="63800" checksum="947DC13E662D1C06" modified="2013-05-29" version="1">MLNFLYKKVLRRIFFQNKCNFRRLLLSCDHIFFIRTLSIARKQENKEIDGRLKNFFKEKIEPYPRIEYDEKYIEICSAINTWKDKLKNGERVLNGKEVTIRGRIFSIRSASSKLFFYDIYAFGAKIQSVCSLQTYKDDASIFLKMNKNLRRGDIVEMTGILGKTNLGEFSIFTSKIQLLAPCLHSLPSKVKNVEKHIKNRFVDFLVHPEISNSIILRSKILTYIREFLLNRNFLEVETPILSGSTGGANARPFYTHANSLDGRRILLRIAPELWLKKLVIGGFDKVFEIGKCFRNEGLDSSHNPEFTICEFYQTYISLNDLIEITKSLLSGLIKELTNNNLLKGNILSLVNNSFFDTYKILDFIPSLENRLGTSLPNLDLPSAVDDLLNIASEKNIPLLKPYTVNRILDQFSTQLLVSECNQPTFIIHHPQVMSPLSKSSTRHNQNIAYRGELYILKKEICNFYEEENAPLQQNLKFLRQQQDRDHHGDSDIQLIDSTYIDALEWGLPPTGGWGMGIDRLCMLLSNQQQINEILTFGNLRMTCSTAKSLSQSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTX9</accession>
    <name>M7NTX9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_00872</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872782.1">
        <property type="nucleotide sequence ID" value="XM_007874591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTX9"/>
    <dbReference type="STRING" id="1069680.M7NTX9"/>
    <dbReference type="GeneID" id="19894570"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00872"/>
    <dbReference type="eggNOG" id="KOG0381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1023494_0_0_1"/>
    <dbReference type="OMA" id="NDNERKP"/>
    <dbReference type="OrthoDB" id="5550281at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09011">
        <property type="entry name" value="HMG_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="106"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="106"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="173"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="205"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR10722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="272" mass="31225" checksum="79C12AE3F7CEF4B9" modified="2013-05-29" version="1">MLSSKNNQFDMSYIEAWRKKQAALASAFRLLSEACSAAARELQDFPLPPFSSFSSEPAKNMTGTQVTVEKSVVSSPEIQMTQENSQELQIDSTEIKKRKVRDPNQPKRPLSAYLSFQLKTRQAVKDSLGENATQKEILSEIAERWSKLNDNERKPFEEEARKAREQYDKEMTAYKCSSESKGQENLHSTKESTIVAHTKVLSIQKDIEENKESLEVVSTPKKEKTMDSAETRESSKEKKRKHKKKSDGQRSQEDTSSTKEKKERKKHKKKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTY7</accession>
    <name>M7NTY7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 10">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 10">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01286</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 10"/>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873210.1">
        <property type="nucleotide sequence ID" value="XM_007875019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTY7"/>
    <dbReference type="STRING" id="1069680.M7NTY7"/>
    <dbReference type="GeneID" id="19894983"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01286"/>
    <dbReference type="eggNOG" id="KOG3754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010467_0_0_1"/>
    <dbReference type="OMA" id="IAHMFIR"/>
    <dbReference type="OrthoDB" id="7939818at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098849">
        <property type="term" value="P:cellular detoxification of cadmium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046938">
        <property type="term" value="P:phytochelatin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000002">
        <property type="entry name" value="Glutamate--cysteine ligase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR10581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="662" mass="76823" checksum="BDC0FBA4381E638A" modified="2013-05-29" version="1">MGLLISGTPLSWEETQQQADYVRKQGIEQFLHIWKEAKKKKKKQLLWGDEIEYMLISYDDKNKIASLSLQQDNILKSIENYKEANKDSEFLDDRKTKYDIFPSFHSEYGNYMIEGIPGIPYGEEIEALLDIEENMKNRRVIIKKYIKPNEIILTLTSFPRLGAPGVFTDPYHPPKGRISCSLFLPDEIISPHIRFLTLTKNIRLRRGKKVVINVPIFIDENTPLPFIDEAASLLNTTCPESVESLHEIIKPNHIYMDSMCFGMGCCCLQVTFQTTDISQAKILYDQLIPMGPIMLSLTAASPAYKGYLSDQDCRWNVISRCVDDRTAEEMGEEPLKNHKFVISKSRYDSVDCYIANDTKNHPKYNDTKLIVDEEIKEKLISNGVDELLANHISHLFIRDPLIIFSNMLIQNKEESGHFENIQSTNWQALRFKPPPPGTDIGWRVEFRTMEIQLSDFENAAYSIFINLLTRIILFYDLNFYIPISKVDENMNTAHHRSSVLTEKFWFRKNIFSVNSCFVKQKSSLKNEQLNKTSKNITMLQVNDEYDEYEKMTIHEIINGQGNIHNGFPGLIPLIQDYFDSINLSQKIRQVLEKYLELIKKRASGEWQTTASWIRSFVRNHPAYRKDSVISQEINYDLIKKAEKISNEFGKNQKLTNYFLGIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7NU56</accession>
    <name>M7NU56_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873280.1">
        <property type="nucleotide sequence ID" value="XM_007875089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NU56"/>
    <dbReference type="STRING" id="1069680.M7NU56"/>
    <dbReference type="GeneID" id="19895047"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01350"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="OMA" id="HKHLGYV"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030998">
        <property type="term" value="C:linear element"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904514">
        <property type="term" value="P:positive regulation of initiation of premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010845">
        <property type="term" value="P:positive regulation of reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22670">
        <property type="entry name" value="FHA_MEK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="5">
        <location>
            <begin position="62"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="171"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="559" mass="64578" checksum="F91655AC2A0636A4" modified="2013-05-29" version="1">MNELYNMKNFCAYPTQLLGCTERISQHASIGEQRSRKGRCAMLLFQGIERDQVVSIYANKEVWVGRHEQCDLVVNQKMASNHHFRIYTVSVEHGFDQTQEIEQLCYCEDLSLNGTYHNGRKIGKHHIVLLSNGDKLDIRHCASFIFQQEHTVTNILKKIDQDIEVFQDKYEITPRLLGLGGFSEIYMAIDKTTGRQVACKVISKISSKFNSSKCLREAQILKNLSHPNIIQVFYEIETEKNYFIFEELIHGGDLYGLCVKYGQLKETDCMFIVLQILKAIQYLQSKNVIHRDLKPENILVTSTSISSGFRVVLTDFGVAQRLGASSRMKTFVGTPSYLAPEIHSCAIRNNNCENIKGYGKEIDLWSLGVIMFALLGGYNPFDNGEVTEKEIMRKVQKGEFDFSGDSWSDVSLEAKDFISGLLRKKPSDRFTVDDAFNHIWISRHRAILEKVYDEKVLFNWNKKLDYSLQKNCYSFLTKNNLSEIQSNILSTNCFSNILKEQEINVNFNIIQKQDDLLKKKDKRKATFQTRCKKRILLENTTAINLPKEILEWKSNKYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NU60</accession>
    <name>M7NU60_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00959</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872872.1">
        <property type="nucleotide sequence ID" value="XM_007874681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NU60"/>
    <dbReference type="STRING" id="1069680.M7NU60"/>
    <dbReference type="GeneID" id="19894657"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00959"/>
    <dbReference type="eggNOG" id="KOG4205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_0_3_1"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12577">
        <property type="entry name" value="RRM1_Hrp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12330">
        <property type="entry name" value="RRM2_Hrp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000025">
        <property type="entry name" value="RNA-binding protein Musashi homolog 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034156">
        <property type="entry name" value="Hrp1_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF6">
        <property type="entry name" value="RNA-BINDING (RRM_RBD_RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="138"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="222"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="445"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="451"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="467"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="525" mass="59478" checksum="2555D23A80FFA011" modified="2013-05-29" version="1">MTMESYEEDDLFRDLYGDDEAEVSLSKLKKDGKIEEKPKNKDLEEIKKEFDSEISKVGLKSDDLSCNIEEEGSGSLFEDEKDISRSFSVKNEDIPKRDEERVDLKEEEEVLCIENEDISKSVEQTVSEVTGSTIREDGKMFIGGLNWETTDESLRAYFEQFGEVTECSVMRDSSTFRSRGFGFLTFKDPKCVNTVMVKEHYLDGKIIDPKRAIPREEQEKTAKMFVGGVSQDCTEEEFKEFFSAFGRVIDATLMIDKDTGRPRGFGFVTFESEAAVENAMAQPYLVIHDKQVEVKRATPKGNLKERTNMTKEKDMNGYDYQRNYFGKDNSGFNFPMDFQSMQQFYGGMSPAIVAQYYQRMQAYIAAMQNMGRGMQIPGGMGRGMMPGIPGFPMGMNMGPMNPMMMNQMNNMMSNMVNFNNTNLPSQSTPQITVPTSNQEIYQVSDDGNINTKKDIQEKDIVQKTDIKTSTTNTTVTPSIQPSRPTPPPNAPTGPSKSASSSRNHRTGYSRNGRGHSFHPYQRRNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUP8</accession>
    <name>M7NUP8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00963</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872876.1">
        <property type="nucleotide sequence ID" value="XM_007874685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUP8"/>
    <dbReference type="STRING" id="1069680.M7NUP8"/>
    <dbReference type="GeneID" id="19894661"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00963"/>
    <dbReference type="eggNOG" id="KOG0412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014853_3_1_1"/>
    <dbReference type="OMA" id="RASECQQ"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048680">
        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="COG4 transport protein middle alpha-helical bundle" evidence="9">
        <location>
            <begin position="161"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR10816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="755" mass="88380" checksum="899E95D4FB6E06C5" modified="2013-05-29" version="1">MNLSCIETVDEVEEYLRDISEECSNIDQRMHDLSLCSNDLDILFAQLNILKFDLEIVHVDIKDFLEILGEVAIRIREISKNIREKKIQQIRLESSIKYIKDVKMLKEWIQNLYYAIDQCNWDVAAKYVSEIRGIEAQVIEGKFAATVIPTENIPMEPKVALQDACDALNTICLKGFHQAAEIKDEKAMTRFFRLFPIIGKSKEGLNVYSEFISNMVIQNKHKLMSAMGILDEKSIDTKISMSYALIMQDMFEYVANIMNHHLPVIKKHYNCEDTLFVIEKIHEKCIEQCSIIIDSFWEERQVEKKLSFIQMYSFEFLIKSFSSTLFQEPNSSLLSQENKAIDIKNIDLLVEEISSILNHWSLYHRFISVKCMEQKQNKLEEIAIKPDSMILATLKMPCYTRLCSIYERMELFFMRHSVEKAFQLDEQDTMSKPLMSSFVDDIMYILKKIVQRVLNTGNLVLLQDVLTGVKRIMEMDYTGIIQRRIIVFQGKLNNQAFSKNQNYKNLKIDNDFISFIILLNNLDISRNYIERIVSESINKDAIKKKFPFESDLIIIFQPIQALLLLQDRLNELLKDGLNTLFLVYIKIRLKKILTDYFNKSTYIINNTIFNDLEKKQPIQLHFSQGWNLIMTNFKHQLTHENMNYLVKMSSNLIANWLEKAILNIKMNELGAIRLDKDISFISSHIISYGSYQSHESFAKVYEMIRILNWDFVQDPLSSDLLETLRFLSIYDVEMLLKRCKSPISNSATRPLFDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUU8</accession>
    <name>M7NUU8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 19">tRNA-dihydrouridine(47) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="2 19">1.3.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">tRNA-dihydrouridine synthase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PNEG_01027</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>5,6-dihydrouridine(47) in tRNA + NAD(+) = uridine(47) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53364"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:53366"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>5,6-dihydrouridine(47) in tRNA + NADP(+) = uridine(47) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53360"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:53362"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the dus family. Dus3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.89" evidence="2 19"/>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872940.1">
        <property type="nucleotide sequence ID" value="XM_007874749.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUU8"/>
    <dbReference type="STRING" id="1069680.M7NUU8"/>
    <dbReference type="GeneID" id="19894725"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01027"/>
    <dbReference type="eggNOG" id="KOG2333">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013299_7_0_1"/>
    <dbReference type="OMA" id="WSYIAEC"/>
    <dbReference type="OrthoDB" id="259935at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106414">
        <property type="term" value="F:mRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102265">
        <property type="term" value="F:tRNA-dihydrouridine47 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25585">
        <property type="entry name" value="zf-CCCH_DUS3L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 19" id="KW-0288">FMN</keyword>
    <keyword evidence="8 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="13 19" id="KW-0520">NAD</keyword>
    <keyword evidence="11 19" id="KW-0521">NADP</keyword>
    <keyword evidence="12 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 19" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10 18 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 18 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="20">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="18">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU291113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EMR10881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="588" mass="67507" checksum="8EDA1CD9DC924901" modified="2013-05-29" version="1">MNEMFNKSEEHGENGDLNANTVDFSLEKTVKNRKRLRGQNKNRKIVIEKELKQLCPRISIDKPCEYGDTCKFMHSIEDYLNEKPQDIGNICCVFNSRGWCRSGWKCRWLGGHLLKPTSDVKTWSLITDNNKMEMHKNDDINYVSADIRKLLSRKLYLTPKSDSYLAFLDGNPYINRFNNKEFENIEKDFPMRIMEKKKICWKGRKILAPLTTVGNVPFRRICSSFGADVTFSEMIVSLPLLQGLKSEWALPRAHISERSNLRNGRRGLFGLQICGSKLWQSVKTAEVLADVCNGIDFIDLNCGCPIDLIYKQGAGSALLDSQTKMIKMLEGMAYVSNSIPITTKIRIGTKDSKPVALKLIARLRNELNLSAVILHGRSRQQRYTKKADWQYIRQCASMINAMRDYDAYNEDSKKNAETGDVCSMAFIGNGDIYSWEDWHAAMMSGVDTAMVARGALIKPWIFEEIDSKQYIDKSSTERLDILKDFCEYGLDYWGSDELGVNTTRRFLCELLSFFHRYVPITMLEVLPPNIQDRPPLWKGRNEMETLLASGNSKDWVKISEMFLGKVKDNTFNFIPKHKSNSYEIETEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NV75</accession>
    <name>M7NV75_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PRKR-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872528.1">
        <property type="nucleotide sequence ID" value="XM_007874337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NV75"/>
    <dbReference type="STRING" id="1069680.M7NV75"/>
    <dbReference type="GeneID" id="19894327"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00629"/>
    <dbReference type="eggNOG" id="KOG4055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079129_2_1_1"/>
    <dbReference type="OMA" id="YERIQLM"/>
    <dbReference type="OrthoDB" id="10067079at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009548">
        <property type="entry name" value="Prkrip1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507:SF0">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06658">
        <property type="entry name" value="DUF1168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="17462" checksum="5578FB0512E1359D" modified="2013-05-29" version="1">MPENLNIEIQEKRKRKRNHLSSIQARELEKLMRRPDREIDLSAPLKPPLPPPPDIVNNVQGSSAGASSGEFHIYKVSRRREYERMKILEEETRHEINEREFNMAREAIIKKDQEKTAKNRARRQKRKQNRANKTKNIAENATLNNDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVA5</accession>
    <name>M7NVA5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00663</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872563.1">
        <property type="nucleotide sequence ID" value="XM_007874372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVA5"/>
    <dbReference type="STRING" id="1069680.M7NVA5"/>
    <dbReference type="GeneID" id="19894361"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00663"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012970_2_0_1"/>
    <dbReference type="OMA" id="LMREPTI"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF87">
        <property type="entry name" value="SIDEROPHORE IRON TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR11066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="65634" checksum="2CB351497C9E61F6" modified="2013-05-29" version="1">MISDGLSEESYLLRQKTQRDVEGVEDISVIWTKQSLIIIYISVFVVMYCISLESQTTSNFILPATSSFGKNSLIPLINTINGILYTAVKQQMLRLSGLIGIMEVFCISLLLYDIGCLMYMISKNIITFIISSIFHTIGTTGFHVLEQFVITDTSELLNRGLLNTILNIPLLINVWVGPNLAQSIYMPKSDSEQWRWGYGIWAIVLSVVSLPMVSILYLNRLKAKEMGLLSIEDNHSRTICAFIKRLFVELDLVGIIILSLGFSLFFFQLIHEFPVLYDAKSVYISSILIILIVLCVVFPLWEFHYAKFPIFSKGLFKMEEITIGYFSSFFYFMGFYLYNNYFTTYLYVTKSNSIKRIGYLNNVFSFTSTIVAIFVGIFVKYNKIYRIFVYIGSPIYIIGIIFMIYNLRTDESVMEMVISQAIIGISGGFYNMSTLVGIQISSTRQQVAINTAVFLTLASVGGAIGSAISGIVWSNLLPKMLNFYSKYLNLFLTPSDYLLIIGSPFMLDQHVKFAKGTVGRMVIVLAYNDVMRTLYICSVICAVPMLLCVMFTENIHIDKTAQDSFKVIDMYRDSDELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVU0</accession>
    <name>M7NVU0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Protein phosphatase methylesterase 1</fullName>
            <shortName evidence="6">PME-1</shortName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00445</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Demethylates proteins that have been reversibly carboxymethylated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48548"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="3.1.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872323.1">
        <property type="nucleotide sequence ID" value="XM_007874132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVU0"/>
    <dbReference type="STRING" id="1069680.M7NVU0"/>
    <dbReference type="GeneID" id="19894143"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00445"/>
    <dbReference type="eggNOG" id="KOG2564">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024818_3_1_1"/>
    <dbReference type="OMA" id="VMVCHHG"/>
    <dbReference type="OrthoDB" id="194865at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051723">
        <property type="term" value="F:protein methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016812">
        <property type="entry name" value="PPase_methylesterase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022950">
        <property type="entry name" value="PPase_methylesterase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="8">
        <location>
            <begin position="114"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR022950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR022950-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="386" mass="43774" checksum="3FEEEB9211E76089" modified="2013-05-29" version="1">MSALHRQVIKEKLISPTLFVKTEFEDVDLNESKTDIDSESVCKLYNENMRMRRFDVKDLESEGNEFVDKMGCEDFNTLWSGYFEKSLKIGPFQVYLTVPKLSETKEGTGMSFFIMHHGAGSCGLSFACLAKEITKITNGACGVLSFDVRGHGISDEVLQNGLLDLRLEELSKDFVKMVELVCQNFGWDDISEIVLVGHSIGGAVLTHVAKNQLLPNILGCAVLDIVEGSAINSFSTMMYHLLKRPKFFSSIREGIDWHLKNKILKNEQSAKVSIPLLFKRQISLNTGKNKWIWRVDLNETEPFWHGWLNGLSDCFLAIPSAKLLILSSKDRLDKTLMIAQMQGKFQLLTFQNTGHFIHEDLPELTAKALVSFWKRNQKSLELSKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWM8</accession>
    <name>M7NWM8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_00128</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871987.1">
        <property type="nucleotide sequence ID" value="XM_007873796.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWM8"/>
    <dbReference type="STRING" id="1069680.M7NWM8"/>
    <dbReference type="GeneID" id="19893826"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00128"/>
    <dbReference type="eggNOG" id="KOG1430">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="STAHWFD"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102175">
        <property type="term" value="F:3-beta-hydroxysteroid dehydrogenase (NAD+)/C4-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="4">
        <location>
            <begin position="5"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR11692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="343" mass="38853" checksum="9721F90443B8AEF8" modified="2013-05-29" version="1">MEYPLIIGGSGFVGESLVSQLVKEKTCKKITVFDINIKDKGFTSVNYYKGDICDIERLREVIRQNHSDVIFHMASPIHGLGKKIYEKVNVEGTKQVIRAALYENVKVIIYTSSAGVVFNGKDLINVDETMPIPKGTMDAYNETKAEAERLILEANGKNGLMTVAIRPSGIFGPGDAQLIPGMISVLKNRQTRFRIGNNMNLFDFTYVDNVVHAHLLASQKLFSPEATNISGQAFFITNGEPIYFWDFPSTVWAYLGHVPSNIIHFPRYLGIIIAFIFEFFSFITRKEPDFTRFRVKLSCANRYYNINKARRLLDYSPIVNLDEGIKRSLKWIESKKNGLGLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWR0</accession>
    <name>M7NWR0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="5">5.3.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphohexomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phosphomannose isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PNEG_00035</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="5"/>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871886.1">
        <property type="nucleotide sequence ID" value="XM_007873695.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWR0"/>
    <dbReference type="STRING" id="1069680.M7NWR0"/>
    <dbReference type="GeneID" id="19893733"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00035"/>
    <dbReference type="eggNOG" id="KOG2757">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026967_0_0_1"/>
    <dbReference type="OMA" id="DIGLFCG"/>
    <dbReference type="OrthoDB" id="6605218at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07011">
        <property type="entry name" value="cupin_PMI_type_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.441.10">
        <property type="entry name" value="Phosphomannose Isomerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018050">
        <property type="entry name" value="Pmannose_isomerase-type1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046456">
        <property type="entry name" value="PMI_typeI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046457">
        <property type="entry name" value="PMI_typeI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046458">
        <property type="entry name" value="PMI_typeI_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF0">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20511">
        <property type="entry name" value="PMI_typeI_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20512">
        <property type="entry name" value="PMI_typeI_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001480">
        <property type="entry name" value="Mannose-6-phosphate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00965">
        <property type="entry name" value="PMI_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphomannose isomerase type I catalytic" evidence="16">
        <location>
            <begin position="5"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I helical insertion" evidence="17">
        <location>
            <begin position="165"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I C-terminal" evidence="15">
        <location>
            <begin position="331"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMR11591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="413" mass="47304" checksum="DFFAA32B1D5B873B" modified="2013-05-29" version="1">MTDFFRLECGFKTYEWGQIGFSSCIARFLASAQPEVTLHCDEPYAELWMGVHPSAPSIVQYSRQFLQNHLEMNQVLLTKSIIDAYGPTLPFLFKILSINKALSIQAHPDKMLAQILHNKDPKNYPDANHKPEMAIAITPFEALCGFRPLEEICEFLESVKAFNELVGDEVTFDFIKHVKIGQNMESNRLILSKLFKTFIQQPRTHVEICAKKLIQFILKNKKTEWGDLILRLNEQFPSDIGLFCVFLLNHIQLKPGEGLFLEANTPHAYLSGEIVECMASSDNVVRVGFTPKYKDVNTLISMLSYKYGLESVKKMEGKVFERSKGEGDVRLFKPPIDEFEVMKIFIKKDQKHWIEGLKGPSIMICIQGEGEVKVNGNIYKMNLGFVYFVGAFVETEMIGKSQEWIIYRAFLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M7P2I6</accession>
    <name>M7P2I6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_03535</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875627.1">
        <property type="nucleotide sequence ID" value="XM_007877436.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P2I6"/>
    <dbReference type="STRING" id="1069680.M7P2I6"/>
    <dbReference type="GeneID" id="19897222"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03535"/>
    <dbReference type="eggNOG" id="KOG1871">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008279_7_2_1"/>
    <dbReference type="OMA" id="TATKQMY"/>
    <dbReference type="OrthoDB" id="429671at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="7">
        <location>
            <begin position="159"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="538" mass="61769" checksum="61E294E6D61BA933" modified="2013-05-29" version="1">MVEQDLDKSGDNHRPPNGYIQRHFPMLPWYSAPDKPFPRRKYKCLKCLEMMKRSSNAQVETALSEKKSQVECLVMSREKISLNEVSEDKEVNKDDMSVQDNCITSKSWSDLLKGPESSYSNGSSKLVITREMPSNNLKEVFDYVKLKSGRNHNVLIQPRGLINIGNVCFMNVILQVLVFCPPFYNLLDEIGKKMTHSLVNNTSLISALISFIREFPIIDKPVLNGGTTVKKDDFEEFGEPFIPEYVYMAMRGNKLFDSMRRGHQEDAEEFLGLLLDALHEEFVQEMKPNADVFPNNTIRYINCVDFVSTNSFDYSQDKNENEWVEVGPKQKTSIMRSATVSESPLTPIFTGNFRSILRVSGMKPSITLEPYRSLQLDIEPLHIGSIEEALQNITQPEVLNGDWHSSLGEKLKATKQVFIETFPQVLILHLKRFIYDNVGGAQKSYKNVHYPLQFEIPPTVMSPHRRIEKNIKFILFAVVYHHGMSASGGHYTVDLLRQDLHSWIRIDDTHISHILPEHVIPSSDSPNRFAYLLFYLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3A8</accession>
    <name>M7P3A8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosomal protein mS38 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_03143</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875203.1">
        <property type="nucleotide sequence ID" value="XM_007877012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P3A8"/>
    <dbReference type="STRING" id="1069680.M7P3A8"/>
    <dbReference type="GeneID" id="19896830"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03143"/>
    <dbReference type="eggNOG" id="ENOG502SE4R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1579195_0_0_1"/>
    <dbReference type="OrthoDB" id="5379635at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23699">
        <property type="entry name" value="At5g63150_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="Ribosomal_mS38_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="COX24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01155">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal protein mS38 C-terminal" evidence="3">
        <location>
            <begin position="136"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="169" mass="20368" checksum="C2A98CCFBED37988" modified="2013-05-29" version="1">MRHNILHHLFRRSQIPLKLPWSSCPVTVNPLDLTISLIWSQHRPLALFHQNQKIQGDEPLVMPKISANPNKTSFVWPEKIRHRLNFFKTNLSNELLFETSLSHFQPSCSERKIFFYPTLSTSFFSPILYNFYEKRQATSVKRKRRLKMNKHKFRKRRDRQRALRKRLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3Z2</accession>
    <name>M7P3Z2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_03056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875112.1">
        <property type="nucleotide sequence ID" value="XM_007876921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P3Z2"/>
    <dbReference type="STRING" id="1069680.M7P3Z2"/>
    <dbReference type="GeneID" id="19896743"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03056"/>
    <dbReference type="eggNOG" id="KOG0154">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_604278_0_0_1"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02325">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051189">
        <property type="entry name" value="Splicing_assoc_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14195">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="2">
        <location>
            <begin position="281"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="1">
        <location>
            <begin position="410"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="52525" checksum="2E6948C899D44F0E" modified="2013-05-29" version="1">MKKTVLSDTNVIHGLYPCLFESSVLTLNDTKNKPYKLSSKSLGALKPDDFPEEILFVGKRCKELKKELSGIYKNKYKSSGNDEATEEDKCERDLIKNFGFINFKSSQKPSLSGSRKVKGLKNKVKYTKEDDAELDYIENITASGYLNYDELLKEYELSSVFLDEEDVVIHDDGNLSEKNKYDIYNRFEFDTCSIPRSDRRVWKNNRISLSYLNKRFKKNYDLEDDNYFSFYNNNLENLENSGKNVGRKKHQKPYGKVSVLENLKKDERENKKDKMVGRTFRELLLHVNDIILCFLSDCDLMDLDLVPMDSHARKWVHILADAYGIVSKSSGKKELRHVVLYKTTRVHDNYSKRHVARILQILNYKQYNFKVSRMKGSESEDNYRKISKNRHKYKYHDGDIVGKDAPEIDKDNKGRMMLEKLGWIAGNGLGAADNKGIEVPVMAVIKTTKLGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M7P432</accession>
    <name>M7P432_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875157.1">
        <property type="nucleotide sequence ID" value="XM_007876966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P432"/>
    <dbReference type="GeneID" id="19896789"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03102"/>
    <dbReference type="eggNOG" id="ENOG502SD6F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_625721_0_0_1"/>
    <dbReference type="OrthoDB" id="5341823at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="452" mass="53005" checksum="2BF4F847B3B3AC0D" modified="2013-05-29" version="1">MIDIVENKDLNLGENRDFLASENLTVNSQNEEEKVDENENKSIYFEKKSEEDNGYVPFFAKKPRRSNNPLHILIQECSRQYIVNFLSKKSESCQRQLISDFDKLKDDLKLFCNYDVLENAKESIISQNEKFQYEDINLDSEIINLRFDEKDAVIKSFSDAIDELYYENSKKSKDVTEELDLDSIDKSLRIWYELAASNHIKDDTKCFLKNVPREPKNMEQKRNMSRNRQRSRYRDKKYSKNVENSHSIHYSDSRRGRGRKEMREKFRSLQKDHSNTSNCSLSIQKNSNENSLNNSANLIPGYIHPNFHHPGLPYNNYVQQNYIDYNHIQMSANHTSYPVQYNNAYYNYINPQNVQYGAPLMNNQYQKLKNYSEINQSNIPITWNSQENISFTSDQQGRHQHLPLPSDFMLGPIDGARIVMPEPHYVLGVIKGMVIRDGQGNFGISKYSFIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7P4A2</accession>
    <name>M7P4A2_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02857</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874895.1">
        <property type="nucleotide sequence ID" value="XM_007876704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P4A2"/>
    <dbReference type="STRING" id="1069680.M7P4A2"/>
    <dbReference type="GeneID" id="19896544"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02857"/>
    <dbReference type="eggNOG" id="KOG0299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014017_1_1_1"/>
    <dbReference type="OMA" id="MPEQARM"/>
    <dbReference type="OrthoDB" id="189968at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000509">
        <property type="entry name" value="U3 small nucleolar RNA-interacting protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039241">
        <property type="entry name" value="Rrp9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="129"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="224"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="266"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="387"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="489" mass="56541" checksum="9157FBDD0C26E576" modified="2013-05-29" version="1">MESLNIWQKLHLKKKETINKKRYFNKNYDSDENKKKNENTNLENNIEHNINKYLSSDDESITRKRLKLAKQYIQKIQTEVGDYDFDAKNIDKDLISERLNENIIEHKRKIYLYIADDLEIYEQPSSNFIQGHKLSVTSVDTYENYIYSVSKDGLLQKWDISDINNPKKLAYALGGKRNDESFEGHISEITDVKVSGDGNCVVTCGKDKRIVVRNSSTLNIICTFKHHRGSVLALAFRKGTNQLYSCSSDRTIKFWSLDEMAYIQTLFGHQEAIPDIASLSLERCVSVGSRDRTARLWKIAEESQMIFKREDKKNNESQEGSIDCVTMIDENHFLTGSDNGNICLWSIYKRKPIFTIYCAHGYDSLKSSQYSAELDTSFLPFHKPRWITSLTSLPYSDIFLSGSWDGYIKLWKLSSDLKSFSLITENILPINGIINRLCVTERGKKAENGIRVIAAIGKENRLGRWFKNENAKNGIKFFEIKRLRQKTQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7P4Y1</accession>
    <name>M7P4Y1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874706.1">
        <property type="nucleotide sequence ID" value="XM_007876515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P4Y1"/>
    <dbReference type="STRING" id="1069680.M7P4Y1"/>
    <dbReference type="GeneID" id="19896374"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02683"/>
    <dbReference type="eggNOG" id="KOG1408">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005113_1_0_1"/>
    <dbReference type="OMA" id="WEISEAP"/>
    <dbReference type="OrthoDB" id="6252103at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052779">
        <property type="entry name" value="WDR62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45589">
        <property type="entry name" value="WD REPEAT DOMAIN 62, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45589:SF1">
        <property type="entry name" value="WD REPEAT DOMAIN 62, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="836"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="836"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1008" mass="113583" checksum="D6F4CBBD20DF0481" modified="2013-05-29" version="1">MDLIHKSLSATNFSSKSSDISRSISLFKDNRKISTQPVEGVSLSLVSVPSGSSTTSPTSLSIHRPSSLVLYPAGAVAVLHNIKCSVENKRFFCIPQNLVTDGGFITGNSPFLSSKSNSPLRDSIDTFSNQESSGCQSRLLYDKYCGSIMREELETQNKVREKIKALSCTTISQDKKYIAVGESGKSPRILIYSISSDESLPIAISGHTFGIKCLSFSSDSRYLASVGFLHDATINVWLIIDKTNTIKRIASNRVTSLVRDLSWMGITIVTCGLRHVKLWKWEEEEVSKTSNIGKTSVLEGKNIILGTMSDEDFMSIRSLGKESVILCSSKGEICIVFEGDRSVKRIFNVGYEISCIDINNIDNLLWVAGKRSEIEAYKIYELLDKNNFQEEFKKEMVKSLKPLKPNSGILAIACDYSGNLVVVDGDHSICIIDTNDESKNQIIGGSSTKMMGVKNLHKNFLNAILMTWSISGTVSFWDENEACILTINIAIEQPENISEETIKNELKVVQYNHHDEELIIGDCYGMIKTINLRDQKELWRQMAHDGEITDIDSGVINEKYIMVSSSRDRTIQVWSRDKNSHNWDLEQTLDDHNSCINKARFHKNYQMLISCSADRTIVIRQLHEESGSTQLRYLTKKIISLRSAALDFTFISEDSLRFFVSTLDRQLLQCDTQGQIIGTYKTSEDPKEMVSLDNIAISNVKLSLDTDNTKKTTLEKKFIAALGNDKAIRIYDLLTCSLLAKKYIHTDGATGIAWIESSQLNNKARLVSSGMDVLAIWELSIDDIQKFAPTHGIYTNLKTPIRKIIPKRIIGTFSPIVAKDVSCIQSKKLWKSVSPTRSNFDLSKSDSDSPTSKRISRLSKKIVDQMEDSKRRASSPIRYCSQKQDICLPKKFSDNKDTNDSTIVFNEKNETNINNTKEIQIFNDEDTLTNEINLLIDKLKEIHHDIKAIKNKDTQKRSMLFYNLQNQLISILNDLREQVSPIEIENPNKELLEKYSTQLIALIKDKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7P5X2</accession>
    <name>M7P5X2_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hsp60-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02584</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874599.1">
        <property type="nucleotide sequence ID" value="XM_007876408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P5X2"/>
    <dbReference type="STRING" id="1069680.M7P5X2"/>
    <dbReference type="GeneID" id="19896276"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02584"/>
    <dbReference type="eggNOG" id="KOG0356">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016503_3_0_1"/>
    <dbReference type="OMA" id="TDTDKME"/>
    <dbReference type="OrthoDB" id="1733909at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006458">
        <property type="term" value="P:'de novo' protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000031">
        <property type="entry name" value="60 kDa heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000592">
        <property type="entry name" value="PRK00013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009487">
        <property type="entry name" value="PRK12849.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009488">
        <property type="entry name" value="PRK12850.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009489">
        <property type="entry name" value="PRK12851.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45633">
        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="588" mass="63015" checksum="436786A8BD7040E2" modified="2013-05-29" version="1">MSRLQYLLGLHGGKLLFFIRNQRLNQQRLYSTKELKFGQDIRSSILNGVEVLAKAVSVTLGPKGRNVLIEQSFGSPKITKDGVTVAKSIVLKDKFENLGARLVQDVANKTNETAGDGTTTATVLARAILSESVKNVAAGCNPMDLRRGAQKAVDEVVKFLQKNKRDITTSEEIAQVATISANGDKHIGRLISNAMEKVGKEGVITVKEGKTIDDELEITEGMRFDRGYISPYFITDVKTQKCEFEKPLILLSEKKISALQDILPSLEIAVNQRRPLVIIAEDVEGEALAACILNKLRGQLQIAAVKAPGFGDNRKSILGDIGILTGGQVFTDELDMKLERVTPELLGSTGSVTITKEDIILLNGDGQKDMISQRCEQIRLAINDPSTSEYEKEKLQERLAKLSGGVAVIRVGGASEVEVGEKKDRFVDALNATRAAVEEGILPGGGTAILKAVSVLNVVAEKMDSFDEKLGVKTIQNAIQQPTRLIVQNTGVEDGSVIINRLTQEYGDQFLMGYDAVTGKICNMVSAGVVDPLKVVKTALVDAFSVASLMATSECAIVDAPEPPSPPGGPGNMGGMGGMGNMGGMGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7P629</accession>
    <name>M7P629_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein mago nashi</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mago nashi family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874244.1">
        <property type="nucleotide sequence ID" value="XM_007876053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P629"/>
    <dbReference type="STRING" id="1069680.M7P629"/>
    <dbReference type="GeneID" id="19895948"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02255"/>
    <dbReference type="eggNOG" id="KOG3392">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109497_1_1_1"/>
    <dbReference type="OMA" id="IRKEMWI"/>
    <dbReference type="OrthoDB" id="6495301at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11295">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1560.10:FF:000001">
        <property type="entry name" value="Protein mago nashi homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1560.10">
        <property type="entry name" value="Mago nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004023">
        <property type="entry name" value="Mago_nashi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036605">
        <property type="entry name" value="Mago_nashi_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638:SF0">
        <property type="entry name" value="MAGO HOMOLOG, EXON JUNCTION COMPLEX SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638">
        <property type="entry name" value="PROTEIN MAGO NASHI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02792">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89817">
        <property type="entry name" value="Mago nashi protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR09295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="17498" checksum="0B9E9126867D9141" modified="2013-05-29" version="1">MVSDKESFYLRYYSGHTGRFGHEFLEFDFRADGMSRYANNSNYRNDSLIRKEMCVSQSVISELKRIIKESEIMKENDSKWPKKDKDGRQELEIRLGNNHISFETAKIGSLVDVQESEDPEGLRVFYYLVQDLKALSFSLISLHFKIRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6F7</accession>
    <name>M7P6F7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sphingolipid long chain base-responsive protein LSP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02399</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Negative regulator of cell wall integrity (CWI) in unstressed cells, probably by inhibiting protein kinase ksg1/ppk21 activity and regulating their downstream CWI pathways pck2-MAP kinase pathway and protein kinase gad8 pathway. Activity may be regulated by the transient increase of sphingolipid long chain bases (LCBs) during heat stress.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874403.1">
        <property type="nucleotide sequence ID" value="XM_007876212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P6F7"/>
    <dbReference type="STRING" id="1069680.M7P6F7"/>
    <dbReference type="GeneID" id="19896092"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02399"/>
    <dbReference type="eggNOG" id="ENOG502RCV0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046464_2_1_1"/>
    <dbReference type="OMA" id="MTRQKFK"/>
    <dbReference type="OrthoDB" id="5599269at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036286">
        <property type="term" value="C:eisosome filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000005">
        <property type="entry name" value="Sphingolipid long chain base-responsive pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028245">
        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962:SF4">
        <property type="entry name" value="PRIMARY COMPONENT OF EISOSOMES (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13805">
        <property type="entry name" value="Pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00053166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="33458" checksum="5E8118A8C70EFA81" modified="2013-05-29" version="1">MNRSHSLRHGRPTSGSSRTNGHRFTFLSLRGHATHTSLPKLIKMENNLVSAYETAGREQQTVASQLSQWGEETGDDAIGDLSDKVAVILSEIGDIEENHASQIDDSRRVLKTIRNIENSVQPLRDAKQKLIDQIVILKHKDPESIKLIEQEQKLVRLEAENLVAEAQLTHVSRQKLKEAYNMYFLSVQERAEKQCLLSHYGRKLLDLLDDNPVIPGDTRIAYESEKEAKELLLEAEEALHSWRPGQLSYEREYTSNNNLVTDQSHNNFRKPDLSTVAIIKRETNEETEKSISLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6M9</accession>
    <name>M7P6M9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribosomal RNA-processing protein 44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_02126</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874107.1">
        <property type="nucleotide sequence ID" value="XM_007875916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P6M9"/>
    <dbReference type="STRING" id="1069680.M7P6M9"/>
    <dbReference type="GeneID" id="19895819"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02126"/>
    <dbReference type="eggNOG" id="KOG2102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002333_5_0_1"/>
    <dbReference type="OMA" id="GQVMRNN"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990251">
        <property type="term" value="C:nuclear exosome focus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033621">
        <property type="term" value="P:nuclear mRNA surveillance of meiosis-specific transcripts"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030847">
        <property type="term" value="P:termination of RNA polymerase II transcription, exosome-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09862">
        <property type="entry name" value="PIN_Rrp44-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000001">
        <property type="entry name" value="Exosome complex exonuclease exoribonuclease (Rrp44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033771">
        <property type="entry name" value="Rrp44_CSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033770">
        <property type="entry name" value="RRP44_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF35">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RRP44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17216">
        <property type="entry name" value="Rrp44_CSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17215">
        <property type="entry name" value="Rrp44_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="12">
        <location>
            <begin position="68"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="RNB" evidence="13">
        <location>
            <begin position="504"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR09540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="985" mass="113144" checksum="EDCCDF4A0D3BCBFE" modified="2013-05-29" version="1">MFHQNIFIQCHGKKILKIGREQYLRRNISCGSQICIPCAFFPPFSECSAKISALSSTPKAINGLENGCYVVPDTNVFYHCMNLIEKESVFNDIIVLQTVLEELKKLSLSAYTFLRQYVASLDKRFYVFYNEFHLETYVERMDDETINDRNDRGKVLAIRTACKWYISHLKEVTRGTKTVVPEILLLTDDKENRSKAKDEGIHAYSVEEYLSEFPNSDELLDMISSVSEADSLSKKGISLYPEYYSCSFISNGIKTGKLYQGEFNVNPYNFLEANVSISNFEKPVIILGKENINRAIQGDIVAIELFQKEHWRTLTSKIIEQETLSINENAEVEKSEEVITQKDQQEIINEQCTLKDRREKENNIFPTGKVVGIIKRNWKTYVGQIDPKSVVVSNNTRIQQTVFFIPTDKRIPKIRIKTRQGPVLLDQKILVNIDAWDRDSRYPRGHFVRSLGKLQANETEMEALLIEYDIQHSPFPKSVLDCLPSEGDKWEVSSVMTPSDWEKRRDFRHLPVCSIDPPGCVDIDDALHASPLANGNFEVGVHIADVSYFVKPGTAIDIEASERGTTVYLVDKRIDMLPLLLGTNLCSLKPGVERFAFSVIWEMTFEAEIVKTEFVKSVIKSRSAFTYERAQLEIDNKIQNNELSFSIKTLLMLSRKLRQKRYDNGALNLTSPELKLEIGTETSDKITLESKKLYETNFLVEEFMLLANISVAHKIYEVYPESAILRRHVAPPKENFETLRDILKVRRNMILNTDSSKSLALSLDKCVDPNEPYFNTLLRIMVTRCMSSAEYFFAGNYNYSELKHYGLAVDIYTHWTSPIRRYADIITHRQLAVAIGYESFQPVLQDKSKLEKICKNINYKHRMGQIVGRSSLEYYVSRTLEKEIYEDAFVMKVFKNGFLVFVSSLGIEGLVYTRDICKSESAVLFDPESYSLVISQLKSDIFNIDNEFSQGILNIGVFDKCRVKICVIKESTGRKKINIQFIKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6U2</accession>
    <name>M7P6U2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="16">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PNEG_02188</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Protein phosphatase that specifically binds to and dephosphorylates the molecular chaperone Hsp90. Dephosphorylation positively regulates the Hsp90 chaperone machinery.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:20630"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="16"/>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874172.1">
        <property type="nucleotide sequence ID" value="XM_007875981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P6U2"/>
    <dbReference type="STRING" id="1069680.M7P6U2"/>
    <dbReference type="GeneID" id="19895881"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02188"/>
    <dbReference type="eggNOG" id="KOG0376">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_5_2_1"/>
    <dbReference type="OMA" id="IHKKYAF"/>
    <dbReference type="OrthoDB" id="445564at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07417">
        <property type="entry name" value="MPP_PP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000039">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041753">
        <property type="entry name" value="PP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 15" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="19"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="17">
        <location>
            <begin position="289"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMR09605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="487" mass="55537" checksum="35B78DD3EC0AC7A9" modified="2013-05-29" version="1">MSNLSSIFSQIPLEDTKRAMQLKNQGNKLLLEKSFSEAIKLYSQAIELDPTKAVYFTNRAYAYINLESYRLAIEDASKAISIDPSYLKAYYRRAIAYTATLRHSDALKDYHTIIKHIPNDFETRRKAIECEKIIRRIKFEKAIDVGEESSATEGIDFDAIVIKDDYDGERLGESMTLEFINDMISRFSNGKKIHLKYVYQIILSIKKILSLEPTMIEVDIKSDHILTICGDIHGQYFDLLEIFRLNGKPSETNRYLFNGDFVDRGSWSTEVVLLLYAYKWLYPTGIFLNRGNHETDDMNKIYGFEGECKAKYTERTFKLFSESFNCLPLATLIGRTYLVIHGGLFSNDNVTLNDIKNIDRISKKQPGNTGLMMEILWTDPQPSLGRGPSKRGVGLQFGPDVTKKFVEANNLKAIIRSHEVKPNGYEVEHNGYCITVFSAPNYCDTQGNKGAYIRIGPNLELEFKTFDAVPHPNIPPMKYATGLISIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6V0</accession>
    <name>M7P6V0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874182.1">
        <property type="nucleotide sequence ID" value="XM_007875991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P6V0"/>
    <dbReference type="GeneID" id="19895891"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02198"/>
    <dbReference type="eggNOG" id="ENOG502QV47">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012743_2_0_1"/>
    <dbReference type="OMA" id="WWSRYGL"/>
    <dbReference type="OrthoDB" id="5541877at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039966">
        <property type="entry name" value="C553.12c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40467">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40467:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="497" mass="57949" checksum="D0177E76D6EC051F" modified="2013-05-29" version="1">MISGRYRVLPRRKSLLFWTSPSREHSNSISTLWFEEGTYEGEFNENSTLLEGLVIAPQKKIIKRILYGFWRRLFILNILPSVIVLIWCAIPFPLSESTNNALSPLRKKCLNFWFFLFIYYGFYNAIGLLWITKLFNLFSLNWWPASLGGAISYTFFWTFSVFLGSLIYLFSEKAEYTLTWILLTFCTMAGPIVVAFAVLRASHRHMNCHSSSYTEETFFNRTFDTHFPSSYIRFLWFCLILVIGLAAFAAGEAYARLYLKTLPHSSTDALLYVYSWITTVYILDMITVWILSYKIKSESLAWVFKLYYAMTLQIYVRNLYARLHSPQQFAVIQGASSFTVIIIVPALMTKWAYKGYLFFTKSQIDYQEYKKNSGRSFYIKTLAQNITMISFLGWVCILHFGPNKSVYPYFTFSTDVPSNDDVYSFKLTFFATLVVWASELISSFITRLIMKLFFKFEVTNEALKDMMEFPDILPAALSVCIHVLQNMLFSIIHLEFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7P7Q9</accession>
    <name>M7P7Q9_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01656</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873617.1">
        <property type="nucleotide sequence ID" value="XM_007875426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P7Q9"/>
    <dbReference type="STRING" id="1069680.M7P7Q9"/>
    <dbReference type="GeneID" id="19895350"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01656"/>
    <dbReference type="eggNOG" id="KOG0010">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024293_0_1_1"/>
    <dbReference type="OMA" id="PGMDMFG"/>
    <dbReference type="OrthoDB" id="267397at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072665">
        <property type="term" value="P:protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030474">
        <property type="term" value="P:spindle pole body duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14324">
        <property type="entry name" value="UBA_Dsk2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16106">
        <property type="entry name" value="Ubl_Dsk2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000205">
        <property type="entry name" value="2'-5'-oligoadenylate synthase-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23195">
        <property type="entry name" value="UBQLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="324"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR09895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="370" mass="40940" checksum="110CAD2EB859A11B" modified="2013-05-29" version="1">MKITINVKASNDKKYAIEVDTDATIEEFKQLISSKTDITPERQRLIYSGRVLKDEEKIETYKISDGHTVHLVRGAGPLQSERDVASSAMPASQQIPRTILAGTGINNPFSALISAHYAGQIHLPPVSTFGPDGGMTSFPPTPEQFSQLMGQQGMQEVIREMFSNSQLMDYIINSNPQLRNVPSGIQEIIRSEEFIRIMSNPETIRQIMEMQRVFGNLGMGVGNLFLTSNEPRTETASTYQQHLPSVDTQNRTDSLGPLLNPAENEPTQQNPDPTALNNSFATMVSLLSNLGAHQQNTDTSVFDPVVFQSFLSGLIPQQPQHLLPPEERFQEQLRQLNELGFTNFDRNIRALGRSGGSVQGAIEAMLDGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7P7Z8</accession>
    <name>M7P7Z8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_01758</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873722.1">
        <property type="nucleotide sequence ID" value="XM_007875531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P7Z8"/>
    <dbReference type="STRING" id="1069680.M7P7Z8"/>
    <dbReference type="GeneID" id="19895452"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01758"/>
    <dbReference type="eggNOG" id="KOG0663">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="OMA" id="WVARATN"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07843">
        <property type="entry name" value="STKc_CDC2L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000054">
        <property type="entry name" value="Cyclin-dependent kinase 11B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000211">
        <property type="entry name" value="Cyclin-dependent kinase G-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045267">
        <property type="entry name" value="CDK11/PITSLRE_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="123"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="437"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR10000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="476" mass="55163" checksum="D9678670C5FC6EC4" modified="2013-05-29" version="1">MLPAKSKWDKEDDDPLDTQWYLSEKERRKKTKQERHSEKTSYKENLEKKEGRNETKRVNIEEEESDDPTKYEKNEYLSDPRVINQVEKSEKSFKKMKYESSLKMSPNIEKNTGIGHCRSVENYTCLNHIEEGSYGIVYRAKNNQTGEIVALKKLKLDQEKNGFPITSLREIRTLFALDHPNIVNIREIVVGDSLTQIYIVMDFVDHDLKSLMEDMTQNFLQSEVKTLMQQLLSATAHMHSKWILHRDLKTSNLLMTNRGMIKIADFGLSRYHGDPAPPMTQLIVTLWYRSPEILLGTHKYGTAVDMWSIGCIFAELLTREPLIRGKGEIDQLSKIFDLIGVPTEETWPGFMNLPNSKNMHFPKKKSSTGSRLRTKFPFLTNAGVDLLANLLTLDPNKRISAHDALQHRYFTEDPKPKDPALFPTFPSKASEERCRRYQSPDAPHAQQYDSISSFDSPKLFDTQSTTRPNYFQLRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7P8I8</accession>
    <name>M7P8I8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01454</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873394.1">
        <property type="nucleotide sequence ID" value="XM_007875203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P8I8"/>
    <dbReference type="STRING" id="1069680.M7P8I8"/>
    <dbReference type="GeneID" id="19895151"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01454"/>
    <dbReference type="eggNOG" id="KOG1516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_8_1_1"/>
    <dbReference type="OMA" id="PTMFTTV"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007317847" description="Carboxylesterase type B domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="141"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR10180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="706" mass="79274" checksum="33DD013DB054F4F5" modified="2013-05-29" version="1">MQLKLLRLFIGLGFLSSIKAVYLLAEDILGSEGNLNSFLVSNPCISCDKYNEGLYNYKEAPKSTKDAILRRLRCYNHSLSGNKDYYFIKTLNEHKCNALNIKNGKVYIVDCDLPFSSICTNSGKERDVKTPPSTDKKLSYTVNSAFGKVTGTRTDLTFTFLGIPYALPPVGNLRFDDPVRISKLKKTWNATYYRSYCPQDNTLIPSPVISEDCLYLNVYTPYIPEDGDCDSQLLPVMLWIHGGAYIHGNLQDIYNDPSHLVAHENVVVVTINYRLGAFGFWGCGNQGIKDQIVALQWVREFISFFGGDPLRVTIAGQSAGASSVRTLLSAKTKTEGLFHAAIMVSDPISMGFASKKDSVTHISKELARYVGCIQNDTSIADPELMKCMRGVSAEEILMYQALIVNTAFLYAETITLGETYKPCIDGDLLTEDFYDSIETGNFVKVPLMLGFVKDEATFFTDTFPKYLETEYLVNLTLSSYFNEEQIDKILAYEYYSKGLNFSDIKSSKDFISNVFTDAVWVCPSLLVAAKTSKFIDSYLYYYIYPYIWEHPSSSLCYGLVCHADDIPAFLGSVAMKGIQTTYGSNGTIVDSDFIFSNLVLSRVGSFLRTHNPNPNVDKLCYNKEFFKVGDCNRRTVKWKSFQPNLSLQDVPSFSSNVSNEKVYGPVHILNLTESTSGNYIIPKDVCDFWFKLGIHAQVYSSKKRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7P8T6</accession>
    <name>M7P8T6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01518</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873460.1">
        <property type="nucleotide sequence ID" value="XM_007875269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P8T6"/>
    <dbReference type="STRING" id="1069680.M7P8T6"/>
    <dbReference type="GeneID" id="19895213"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01518"/>
    <dbReference type="eggNOG" id="KOG2655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017718_0_0_1"/>
    <dbReference type="OMA" id="EASHAEI"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032161">
        <property type="term" value="C:cleavage apparatus septin structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000238">
        <property type="entry name" value="Cell division control 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="27"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="317"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="384" mass="44773" checksum="E9F7D205CE4C323B" modified="2013-05-29" version="1">MVLDKESRNGIGISNLPNQRHKIVARRGATFTLMLAGESGLGKTTWINTLFSTTIKGYSNNKKRFRKQTDQTVEIEITKAEIEERFFRVNLTIVDTPGFGDYVNNNEAWQPIIEFIDDQHESYMRQEQQPRRSEKIDLRVHACLYFIRPTGHTLKPLDVEAMKRLGTRVNLIPVIAKADSLTQTDLAKFKRRIRDVIAAQEINIFTPIVEEDDPAAAEHARNLIAAMPFALIGSDRDVQTPDGRVVKGRQYSWGVAEVENDEHCDFKKLRSLLIRTHMLDLIQTTEEVHYEAYRAQQMEIRKFGEAKTRKLDNPKFREEEEALRKRFTEQVKIEEARFRQWEQRLISERDRLNKDLETAHTSIKQLEAELEHMQTIQNNSGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7P917</accession>
    <name>M7P917_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NCS2</name>
        <name evidence="3" type="synonym">CTU2</name>
        <name evidence="4" type="ORF">PNEG_01581</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTU2/NCS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873535.1">
        <property type="nucleotide sequence ID" value="XM_007875344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P917"/>
    <dbReference type="STRING" id="1069680.M7P917"/>
    <dbReference type="GeneID" id="19895276"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01581"/>
    <dbReference type="eggNOG" id="KOG2594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024534_3_0_1"/>
    <dbReference type="OMA" id="KQRKQMM"/>
    <dbReference type="OrthoDB" id="25129at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03054">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10288">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="427" mass="49642" checksum="D725F2A221DAD764" modified="2013-05-29" version="1">MGCENGCNKVKKYTEDTYCELSNICGRCKEKESSFFSKSEAFCSQCFIIYIKRKFHKTLESFFKEDISFKNNKALIAVSEGTSLALIKFFSENSDKFKFKRYFNILDFIHIEEDGSVKEVSNSSYISEKINEMLPESLFFLINLKNYILNSDENIKLFWDKMSDALLGSQISKESVGSLNDLLSPLSSTTSRMDILKCIRNNIIYNFAEKNGYNVIIFGDTISSIASKIISETAKGRGYSIPWETRGKIKQHLYDIWLLRPMKDILRQEAYYFLEINGIQNIKKFYHKATTIDELVDRYFDDLEKNNPSFLFTVAKTSAKLQVPEIKDTKEYSNSEFCFICQMPKENNVNDWLKKIALDKNDLSNVTNTEINENYENYLNRTKDVCYGCFIMLRGSKSEFILPYFEKGNINSIRNPKDEVLSEYLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7PA39</accession>
    <name>M7PA39_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872780.1">
        <property type="nucleotide sequence ID" value="XM_007874589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PA39"/>
    <dbReference type="STRING" id="1069680.M7PA39"/>
    <dbReference type="GeneID" id="19894568"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00870"/>
    <dbReference type="eggNOG" id="KOG1273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032142_0_0_1"/>
    <dbReference type="OMA" id="DYEDDIM"/>
    <dbReference type="OrthoDB" id="196858at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037850">
        <property type="entry name" value="RBBP5/Swd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040:SF1">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="447" mass="51044" checksum="AC8074F0B21DB085" modified="2013-05-29" version="1">MNLELLNPFSQEYPENLTSSLSYGHAMLIRFDKKGDHLAAGLFDGVIIIWDLLTNGVSRVLKGHTRPIQSVCWSIENRYLLSAARDWRCVLWDLKDGSRIKMIRFNAPIWGAELHPFDREIFVASLLEDVPILTNISGGGIQKRVLPTAPKRPLKEGTEEGEIDEKVISQDTKQLTLVCTFDSTGKYIYTGTTKGWLNIISSTSLEILYSFRLTNSNIKQIRLSPTGKTLAINSTDRIIRTLPIFDNPENLNDDSIKVEHKFQDVINRFQWNACAFSSSGEYVMASTYRSAHVIYIWDRNTGSLVKILEGPKEEFIDIDWHPVFPFIAAAGLETGTIYIWSIPRTEGWSAFAPDFTELEENILYEEREDEFDIVPEETKKSKIEEDADVDIITIDNIQYTAGSFHTEGFLLPVLFDSDYTSSSETDQEKKYIKKLENSKNNIKRKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAW6</accession>
    <name>M7PAW6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Wings apart-like protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00619</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WAPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872517.1">
        <property type="nucleotide sequence ID" value="XM_007874326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PAW6"/>
    <dbReference type="STRING" id="1069680.M7PAW6"/>
    <dbReference type="GeneID" id="19894317"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00619"/>
    <dbReference type="eggNOG" id="ENOG502RS0D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_403903_0_0_1"/>
    <dbReference type="OrthoDB" id="78088at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039874">
        <property type="entry name" value="WAPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022771">
        <property type="entry name" value="WAPL_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100:SF13">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07814">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wings apart-like protein C-terminal" evidence="3">
        <location>
            <begin position="291"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR11020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="681" mass="78376" checksum="C17F0CFEFB6EAC0F" modified="2013-05-29" version="1">MQISTEFHEDDQFYINNYSSSKCEKLESQLSNISSTKRYINQDNKDNLLLSQTNMENANIIEKNIGKETENLKLMSSAHIKINSPKKSKKSINTKNKHYLDTKEITSEKNLNKKATFDTKHSQLLFEPKKSPNKISTKSPKTPNKNSNNASPFSENICQQNNTWNFLDDFDNSPLRTPKSQRIIDSLEHDKLKSPSQIGTPKSKEISIKMFSPILTNEDYKLPKTPQNLYIYNNLVDTFSDIQNTYAKQRSFIAEPANNTKKDIFSSYNADPKNYLNDELNVEDTESYSLNIKSVHELRESGINKKSLDEIQYLMDGLNKYNSLKLRQSCYIELAKKINETEFSRNFRSGNFIHQLLEISKKDTDMIILYCTLFILYLLLQDKKSAYALVSDDTTFEIIFLGLSYDENIQLYNSKNHKSDNSMQDSLIDLIKTVKFSTVHPEYTNKSSCCILSINAIKSIAFLPTWETLNYLEKMESFGFISCLYDIIDKISNNNNSEEFYLIETIIGSIEQCALIMCSNTHIKRISSITTLLTSSLFHNFKKKYKYDIFQSCLRLLINLTNNSSSICDEVTQPKFIQTLTNVIISKKDSLDLDQSSDNTLLTLGLLINIIEKGSKMNYISEQYDTENTLISLLTIDELVDTFTKWRKYSYNTETNVAAGYLAILLAHLSLKNILTRIRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M7PBE1</accession>
    <name>M7PBE1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872701.1">
        <property type="nucleotide sequence ID" value="XM_007874510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PBE1"/>
    <dbReference type="STRING" id="1069680.M7PBE1"/>
    <dbReference type="GeneID" id="19894494"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00796"/>
    <dbReference type="HOGENOM" id="CLU_631798_0_0_1"/>
    <dbReference type="OrthoDB" id="2368680at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="434" mass="50318" checksum="8303AC5AF9C5C359" modified="2013-05-29" version="1">MDAIVKDTQESVLTQQIMHTVHDSDILALSIGKPPPLALRGKINIYSPIFARLAFSLPSSERYGFLCTLALVSKLWNFSVKFAWYHLILLEFPGKRTETWISSLDPTIQTFRLWYIHRQKEKQHVLELFKKSWIERLFRIYGQTFSYNFPTSQKELWFFGICYGLLSDPDERGQWEVSLRFWISHFILRLMSGESWESWPIFFSQMHDNIIIDAKRIGNSDIWRIECSGNKAWYISGQSGEAIGWDFSSGFRSVINMENITWKDLRFDWKKYISTIINESFPSELFDRIFFHGDSSLYPHGIHKSIKDPLRFSLAKRFVLSHVISYGISGSYESRPFSYCSNSKFILDLEKTYSVESVRLSGETAVYNQVLCQGLSYIQTTEVGMFVLDEIGLEVGDDVCGVRDIWALLLGCNTWGNAHDSITAEKMILTLFQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7PBH3</accession>
    <name>M7PBH3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kynurenine 3-monooxygenase</fullName>
            <ecNumber evidence="11">1.14.13.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Biosynthesis of nicotinic acid protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Kynurenine 3-hydroxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BNA4</name>
        <name evidence="14" type="ORF">PNEG_00819</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:20545"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the aromatic-ring hydroxylase family. KMO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.9" evidence="11"/>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872726.1">
        <property type="nucleotide sequence ID" value="XM_007874535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PBH3"/>
    <dbReference type="STRING" id="1069680.M7PBH3"/>
    <dbReference type="GeneID" id="19894517"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00819"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023210_0_1_1"/>
    <dbReference type="OMA" id="REFMFIA"/>
    <dbReference type="OrthoDB" id="10053569at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004502">
        <property type="term" value="F:kynurenine 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070189">
        <property type="term" value="P:kynurenine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000129">
        <property type="entry name" value="Kynurenine 3-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01971">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027545">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028:SF2">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0274">FAD</keyword>
    <keyword evidence="2 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 11" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 11" id="KW-0521">NADP</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 11" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="13">
        <location>
            <begin position="7"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR11230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="459" mass="53160" checksum="64D99F7EFF264EA6" modified="2013-05-29" version="1">MTNIKKIAIVGGGPVGALSALFFGKDGWEVELYERRCDIRNSVNDSLSVRKSINLALSERGIESLRHIGLDKVILENTIPMYGRMIHSTEGKQMSRRYDVYGRYINSIDRKWLTAKLLDEAEKLSNVKLFFDCKVVDCDFDTGTVWFRRNHDVNNLIKTNVDLIIGCDGVYSTVRQSLEKKIMVDFEKKYIDSMWCEFSIPALIKDEAMHYAIEPNYLHIWPRKTFMFIALPNTNKTFTCTLFMPKTMFEKIETEYDLLELFSQNFPDLINLIGHNELVKQFFMNPKSPLLTIKCKPHFYKSKCVIIGDASHCMVPFYGQGMNCGFEDVRLLYQLINLNSTNLEKALINYSSTRYVDVVAMCDLALHNWEDMRSSISQGYAIKKIIEDFLYLRFPLLGIVPLYTMISFSNIRYSLALEKWKRQRKILDFLIYTGGIGTFGGIMYLVTRIIFKGMKFLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7PC33</accession>
    <name>M7PC33_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="6">PPIase</shortName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00468</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872351.1">
        <property type="nucleotide sequence ID" value="XM_007874160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PC33"/>
    <dbReference type="STRING" id="1069680.M7PC33"/>
    <dbReference type="GeneID" id="19894166"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00468"/>
    <dbReference type="eggNOG" id="KOG0881">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_16_3_1"/>
    <dbReference type="OMA" id="ELYNDHA"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000008">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR11450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="158" mass="17473" checksum="5A9207FA94DFAE71" modified="2013-05-29" version="1">MTGNVVLETSMGPITIELYYNHAPKTCKNFYELSRRGYYNNIIFHRVIPDFIIQGGDPTGTGRGGSSIYGDKFEDEIHPDLKHTGAGVISMANSGPGTNGSQFFITLAATPWLDGKHTIFGRVKQGMKVVQRIGLVKTDSNDRPEEDIKIRRAIVTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7PC42</accession>
    <name>M7PC42_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_03486</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875576.1">
        <property type="nucleotide sequence ID" value="XM_007877385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PC42"/>
    <dbReference type="STRING" id="1069680.M7PC42"/>
    <dbReference type="GeneID" id="19897173"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03486"/>
    <dbReference type="eggNOG" id="KOG1510">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094271_1_1_1"/>
    <dbReference type="OMA" id="CEIRNEQ"/>
    <dbReference type="OrthoDB" id="526653at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.10">
        <property type="entry name" value="Mediator complex, subunit Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021384">
        <property type="entry name" value="Mediator_Med21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381">
        <property type="entry name" value="RNA POLYMERASE II HOLOENZYME COMPONENT SRB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11221">
        <property type="entry name" value="Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="83"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="138" mass="16000" checksum="598E860405E692F1" modified="2013-05-29" version="1">MACPCTQLQDAINELATQFYTILEYLNTAHDFVPLDGQTKASDPGVHPEDADKFTEIQHKLSMNLIEKVKQIDLLIDTLPSLYETEQQQLTQLTNLQEQLKEIGQKKHSLRIEKDNLQQQLDKIIFNFTIKRNQIFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7PC95</accession>
    <name>M7PC95_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein ROT1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Protein rot1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_03539</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ROT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875631.1">
        <property type="nucleotide sequence ID" value="XM_007877440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PC95"/>
    <dbReference type="STRING" id="1069680.M7PC95"/>
    <dbReference type="GeneID" id="19897226"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03539"/>
    <dbReference type="eggNOG" id="ENOG502QQTG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071622_0_0_1"/>
    <dbReference type="OMA" id="YKPPQML"/>
    <dbReference type="OrthoDB" id="5327821at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006458">
        <property type="term" value="P:'de novo' protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019623">
        <property type="entry name" value="Rot1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090:SF1">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10681">
        <property type="entry name" value="Rot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082753" description="Protein ROT1" evidence="11">
        <location>
            <begin position="22"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR08099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="228" mass="26328" checksum="99A99CBF573BAC94" modified="2013-05-29" version="1">MNTPIYLLFIALTLFMAGCHSYERGLAGTWTSKSKSVFTGPEFYDPIRDVMFPPRLTGISYSFTDDGYFEESLYRVSSNPTAPECSVAVMQWQHGLYQKLDNGSLLLNPIPSDGRQIFSDPCAGLTSRYTRFSVKELIIKYEVILDPYYKEYKLLLYQFDGTPVQPLYFVHFPPKMLPTVTLTPLSTRILQKRSFESHFFSFLTFNTNYICWIGILMILLGTFGYYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCL5</accession>
    <name>M7PCL5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ribosome biogenesis protein RPF2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00088</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
            <location evidence="1 4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RPF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871945.1">
        <property type="nucleotide sequence ID" value="XM_007873754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCL5"/>
    <dbReference type="STRING" id="1069680.M7PCL5"/>
    <dbReference type="GeneID" id="19893786"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00088"/>
    <dbReference type="eggNOG" id="KOG3031">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049783_0_0_1"/>
    <dbReference type="OMA" id="VGLKPMF"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039770">
        <property type="entry name" value="Rpf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728">
        <property type="entry name" value="BRIX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728:SF0">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="28"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="321" mass="37717" checksum="E81AFB891DE094F7" modified="2013-05-29" version="1">MLRAVKPRNARSKREIEKREPKIQESGRTVLFLRGSTTNRVIQTALLDLYLLKKPNAINFSRKNKIYPFEDTSSLNFLSEKNDASFLVIGSYGKKRQNTLIFVRMFDYQVLDMLELRIENAVSMIEFKNEKCFIGLKPMILFAGSLFESSPKYQLCKSMFLDFFHGQTTDRLNIEGIQYAVCLLTEEPTDENPFPPIFFRVYMIKYLKEKQVGSKIELEEMGPRYDFSIKRTHEANEKMMKEAMKKPKKHLPKIKKNIDIDKMGDKIGQIHLEKQNINQLQTRKFKGLKRKIEDSIEDESFNKNGKKHHRVTFKDDLTLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7PD16</accession>
    <name>M7PD16_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_03184</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MOG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875247.1">
        <property type="nucleotide sequence ID" value="XM_007877056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PD16"/>
    <dbReference type="STRING" id="1069680.M7PD16"/>
    <dbReference type="GeneID" id="19896871"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03184"/>
    <dbReference type="eggNOG" id="KOG3329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081345_1_2_1"/>
    <dbReference type="OMA" id="ECSSAWM"/>
    <dbReference type="OrthoDB" id="10255285at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.10">
        <property type="entry name" value="Mog1/PsbP, alpha/beta/alpha sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007681">
        <property type="entry name" value="Mog1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016123">
        <property type="entry name" value="Mog1/PsbP_a/b/a-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837:SF0">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04603">
        <property type="entry name" value="Mog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55724">
        <property type="entry name" value="Mog1p/PsbP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="220" mass="25334" checksum="C24941E90281224F" modified="2013-05-29" version="1">MLLTSLRYFFGGAITADLPQDFIDASQFREIPDHQEVLVNINDERSIMIELLEFAPVDDIDVSKFHFDLLAQDNEAEESLILNVSCVTLEKSGYTVYLLEGLQKIFKYNKQSADYVNKEVVNPLLVPYVAIFLSVLRLHEKSTDIIISINIPFLEIQYLSSFFKDSSFKISELVSSSDLNHLNILKNIFDMQEVQFSTRETLLNILNTLQIHDWSLFVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7PDA5</accession>
    <name>M7PDA5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_03271</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875342.1">
        <property type="nucleotide sequence ID" value="XM_007877151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PDA5"/>
    <dbReference type="STRING" id="1069680.M7PDA5"/>
    <dbReference type="GeneID" id="19896958"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03271"/>
    <dbReference type="eggNOG" id="KOG2581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019858_1_2_1"/>
    <dbReference type="OMA" id="AKVYFYF"/>
    <dbReference type="OrthoDB" id="1713558at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013586">
        <property type="entry name" value="PSMD3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057985">
        <property type="entry name" value="TPR_PSMD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08375">
        <property type="entry name" value="Rpn3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25573">
        <property type="entry name" value="TPR_PSMD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="225"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="468" mass="54573" checksum="E7820A01A3903496" modified="2013-05-29" version="1">MTDSTKNKVYDESSTISEIKSNIYLLEQAVEQYEPYLISKVLRTTFFLRKHLNGEILKETIRNIYKGKEKTKDYLLNIIKMKTNEMDSNNSREKNKEIAPEIDIYIHLIIQIYLLDTKEYEKGAIFSQELVEKLQTVNRRSLDRISAKIYFYYSYFWEMQGKLSEIRPTILKAQRTATLRHDNETTSMIIILLLRNYLHYNLYNQADRLVSKINFPEFATNNLIARYLYYLGRIRAIQLDYTSAHSHLTNAIRKAPQGAKAAGFLQAAHKLNIIVDLLMGGIPERSIFRQPMLEKALVPYLQIVQAVRKGDITLFTDAFNKHGNKFRLDGTSSLILRLRQNVLRTGIRMMSISYSRISLRDICLKLHLDSEESAEYMVAKSIRDGVVEASLEHEKGYMQSKEVPDIYSTHEPQIAFHDRILFCLNLHASNIKAMRFPMNIHKHEIENAESARKRIENQIVEAEDDFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7PDU4</accession>
    <name>M7PDU4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_03115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875171.1">
        <property type="nucleotide sequence ID" value="XM_007876980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PDU4"/>
    <dbReference type="STRING" id="1069680.M7PDU4"/>
    <dbReference type="GeneID" id="19896802"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03115"/>
    <dbReference type="eggNOG" id="KOG1889">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003016_7_4_1"/>
    <dbReference type="OMA" id="ITKAQPV"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072517">
        <property type="term" value="C:host cell viral assembly compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052629">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061909">
        <property type="term" value="P:autophagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="557"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="114"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="597" mass="70738" checksum="EC81A56732417656" modified="2013-05-29" version="1">MLHQTLYLYTSKDEFVLVPESKSGSLLVIDRLNGKLNLHQRDTYPIPINHEILRIYGILGIIRLKYDKYLIIITEREIVGKIDQNDIFRIKSVRLMSLKNKYKDHEEVEYLNLIKKHLKTGTFYFSYTFDITNTIQRQIVLNTKSPSWEIADERFFWNKFIQSDLIGLRESSHSDIDNYILPVIYGFVKITRIAIKNHFLTILLISRRSRFRAGTRYFSRGIDEDGNVSNFNETEQIVLFENTNKLSGVTKQLKLSFVQIRGSVPIFWAEINNLKYKPKLRVFNINDSVNSARLHFDKQIRIYGDQIIVNLVNQHGREYNIKAAYEEIIKILSDPKIKYFYFDFHQECKKTRWHRVRILIDQLIPYLKQNYCYIDCSDQIFPIYFQTSIVRTNCIDCLDRTNVIQSALARWVLTKQLNDIGIFNDYENIEDYPDFDHLFRNMWADNGDFISISYSGTGALKTDFTRTGKRTKRGEFRDLINSIIRYFQNNFTDGSRQDSFDLFLGNYLPYQAGKISLPYHRSLFIKYIPYVLFFSIFMILAKIILPGLENIIISPHIFLTFWFFVLICSAYFIISNGLYYVNWPKLVPPEFLKYKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M7PE10</accession>
    <name>M7PE10_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FUN14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08704.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613292.1">
        <property type="nucleotide sequence ID" value="XM_019757748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PE10"/>
    <dbReference type="GeneID" id="19896569"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02882"/>
    <dbReference type="HOGENOM" id="CLU_2307210_0_0_1"/>
    <dbReference type="OrthoDB" id="5417857at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08704.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17762" checksum="A58D3D8BDBCDB3B8" modified="2016-03-16" version="2">MSYKITNCICTYLTYTLLNWKSNIGILKINPISCQNRIEKNINHSKITHTSSSCKKNISHAQQLSAGCLVGFLSGVLAKHIGKFAIILFIGIYLVSWTGSFRRFTKPWNMFLYFSQKIWHKKNKSIKEIANELLFKNIVFKSSFAATFGFGFLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7PE42</accession>
    <name>M7PE42_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874955.1">
        <property type="nucleotide sequence ID" value="XM_007876764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PE42"/>
    <dbReference type="STRING" id="1069680.M7PE42"/>
    <dbReference type="GeneID" id="19896601"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02914"/>
    <dbReference type="eggNOG" id="KOG1300">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009210_1_0_1"/>
    <dbReference type="OMA" id="PFTRPHT"/>
    <dbReference type="OrthoDB" id="2228at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="620"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="629"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="682" mass="78558" checksum="AFD86B3141BAC44B" modified="2013-05-29" version="1">MSLIDIVREHFIVSLRSIQPKIKWKIVIVDNESSEIINNVMNLNDFLEENVTSVEFIEQKRQANATLEAIYFVSPKYDTIKHILNDTSKEEKMYSAIHLFFISGLSGKLAKKLTESSKTTPIKTTNEMYLDFYPFESKVVTFRNSFSFLTLYNPFCTELINMETHNLAKKLASVCITLGELPTIRYYSQPSTNSSNPHFCTKIAELLQEQLDNYKKSNNNFPRESSRPKSVLFIIDRTFDICAPIVHEFTYQAMANDLLPIKNGKQYKYQINNSEKAETKEAVLTETDSIWAEIRHQHIRDAIDKLMGDFNKFYAENSDFNDNKKNTSLSDMKNMLYSLPHFQEMRDKYSLHISIVYECMKIFEEHKLFSVGVIEQNCATGLTSEGKVPKTVLEEMIPLLDDSSLSKTDKIRLIMLYIIYKNGIFEGDLDKLSKHSNLSPKDVSVLKNLECLGVRVIKPLNDTKPRRKPILETKNNDENSYELSRFTPLCKTLIEKYINGNLSYALFPSTKDVCEKTQNISLIHGSLRTGKPTWAKKNDLVSESAQRILIFIVGGATYSESRICYELSKTHDRDIILITTNMITTKKWLQNLSMLKLPRESLGLPIDQLPSRIPSLRIHSRSSFRSKRIPKDSNHSNHNRVENSNNTSFKKTLDNSTHENTKNSPAKGKKDRKRYLGLFNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7PE88</accession>
    <name>M7PE88_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Charged multivesicular body protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_02934</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874979.1">
        <property type="nucleotide sequence ID" value="XM_007876788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PE88"/>
    <dbReference type="STRING" id="1069680.M7PE88"/>
    <dbReference type="GeneID" id="19896621"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02934"/>
    <dbReference type="eggNOG" id="KOG2911">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021165_2_0_1"/>
    <dbReference type="OMA" id="NEQMATT"/>
    <dbReference type="OrthoDB" id="10250120at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF18">
        <property type="entry name" value="SORTING PROTEIN SNF7 FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16692)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="52648" checksum="A389AD83983D3921" modified="2013-05-29" version="1">MSDSFYQEKKCQEEDKRTGLLLKYILDHTEFTSSRLPSLYSDFFPLKNSNFEGYQANTNAWKSALEDAVWAGKIEWTCDYLVIHCDNRLSISLYSPKYGIPLGIKETMEYSLEKGEWIRLCDFFKKKDCIYSYALSYMSNFVAWSLGRIGKYILKKAELDTSCIILEHVERAENAFLTVVQDKIMYSEHIYSFDGLVRCFSNKIFSSRILSELDMKIMIYHLSRNKKEATISEDGQIIKLRRKSDARVLNITETDHLISNLKTIFYRLKRLTQTLTQNIIHLDESIKTAIQSKNKTLAMFQLRSKKASELTLNKRLQSLEQVKEILSKIDEAVIHLDILNSMKAGVEVLENLVKEIADIENVKDIMEKFKELSYEVDCIGDTLGTANLNNISDIEIEQEFEKLCDALKNEVIEKPKEDAEIEIINNMFADMDLEVPSLIPHITSKRIEETQLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7PFQ4</accession>
    <name>M7PFQ4_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L43-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02604</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874618.1">
        <property type="nucleotide sequence ID" value="XM_007876427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PFQ4"/>
    <dbReference type="STRING" id="1069680.M7PFQ4"/>
    <dbReference type="GeneID" id="19896296"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02604"/>
    <dbReference type="eggNOG" id="KOG0402">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141199_1_0_1"/>
    <dbReference type="OMA" id="GPRYGRK"/>
    <dbReference type="OrthoDB" id="10258345at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000002">
        <property type="entry name" value="60S ribosomal protein L37a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_eL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050522">
        <property type="entry name" value="Ribosomal_protein_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00280">
        <property type="entry name" value="eL43_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003058">
        <property type="entry name" value="PRK03976.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="92" mass="10343" checksum="92B4B09AB98E786C" modified="2013-05-29" version="1">MTKRTKKVGVTGKYGPRYGSSLRKDIKKMEIQQHSKYVCTFCGKKSVKRKCVGIWRCLRCSKVVAGGAWTVSTTAAASVRSTIRRLREMAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7PG97</accession>
    <name>M7PG97_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Golgi apparatus membrane protein tvp38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02061</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874042.1">
        <property type="nucleotide sequence ID" value="XM_007875851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PG97"/>
    <dbReference type="STRING" id="1069680.M7PG97"/>
    <dbReference type="GeneID" id="19895755"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02061"/>
    <dbReference type="eggNOG" id="KOG3140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021545_0_1_1"/>
    <dbReference type="OMA" id="FWHFVVA"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF2">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="29372" checksum="8B2E88BE3E9938E6" modified="2013-05-29" version="1">MKFHKKYAVFGGTLFLTGPIAMIMMSIHHQKIVDLLAPTADRIQKINGGFLIFASILILCSFPPMFGREIAAILIGFVYGYIGFIIVSISFIIGETLVFLSFRHFCHKQAIQFRNNYKNSYGIFVRIIEEKQITMMFLISLSAIPSHFSTPLFATIDSISYYSWLLVAIPCSVKHVIPVYVGILFRRNQTSLASTVLLIFSIFITIIFFTLICLRYQEIKKNMIFLNSISEEQELGQNKYFDISNSFESANSDLEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7PGN0</accession>
    <name>M7PGN0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02197</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874181.1">
        <property type="nucleotide sequence ID" value="XM_007875990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PGN0"/>
    <dbReference type="STRING" id="1069680.M7PGN0"/>
    <dbReference type="GeneID" id="19895890"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02197"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_7_1_1"/>
    <dbReference type="OMA" id="AFMSTYN"/>
    <dbReference type="OrthoDB" id="10054429at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF13">
        <property type="entry name" value="THIAMINE TRANSPORTER THI9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="58680" checksum="57137D28F37037B8" modified="2013-05-29" version="1">MSLDSGVKEGLKYGVYEEQLSNEDEKQLVSFALPLELELGHTSLSLGYIQSLHRTYQFFDNFSIGFVALYFVGGIRIVYTTGILAGGPQAYWISYLISCFGMCITAAVMAETCSALPVSGSIYLWASKYASPKYRRLIGFVVAWWSISAWVSFVAGNTQSAVNFLLSELPIFGVDFPTFTNVFKFRVVQWFFSEILLALSVSLNYFKPQLFKYVLRMSSMIIILDFLLNVIWLPIGVSKTFGFQDITFLMKTYNSTNAVPIWNWCLSFLSTSGILVGFDAPGHIAEETKNASLAAARSIFISAFVTGLFGLPIVFLFIFCSPKLDVLFSLDVPQPFVYLYSLALGKKAHVFLNLIVVLGHLLNTTVAVLSSSRLVYAVARDSAFSMFDWLSKVDSWRQPRNSVTLVWIVSSIILCTILVSQVAFTSLISAMSLPTVCAYGLIAFLRLLHKPEDCLQAKWSLGRFSRPFQFITFIWCIFIVSVLASPYQFPVSALTFNYAPVMLVLVTLGSLIVYWMAPHNNWLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7PHX4</accession>
    <name>M7PHX4_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PNEG_01815</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>(6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20221"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873786.1">
        <property type="nucleotide sequence ID" value="XM_007875595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PHX4"/>
    <dbReference type="STRING" id="1069680.M7PHX4"/>
    <dbReference type="GeneID" id="19895509"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01815"/>
    <dbReference type="eggNOG" id="KOG4230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003601_2_0_1"/>
    <dbReference type="OMA" id="QPIMFRR"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009257">
        <property type="term" value="P:10-formyltetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000006">
        <property type="entry name" value="Bifunctional protein FolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000245">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000005">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.770:FF:000001">
        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001522">
        <property type="entry name" value="Probable MIS1-C1-tetrahydrofolate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.410.10:FF:000001">
        <property type="entry name" value="Putative formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.410.10">
        <property type="entry name" value="Formyltetrahydrofolate synthetase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF5">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="17" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="14" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="21">
        <location>
            <begin position="14"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="22">
        <location>
            <begin position="151"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00052194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EMR10064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="948" mass="103812" checksum="E4026D13D530E11D" modified="2013-05-29" version="1">MTINNIKNEIAKKINGTAIAKSFYEKIKTEIIEKQSKYPEFRPTLAIIQVGSIEESNTYIRMKRKASEEANIQFQHITFPESIQQSELLNEIFRLNKDFCVHGIIVQFPIPSHLSESAITSAISPLKDVDGLNVLNIGELSKRNGKPFFIPCTPKAVMSIFDSIGIELEGRNAVVIGRSNIVGNPMSCLLRNANATVTVCHSKTRNIKEVCRQADILVVAIGQPEYINADWVKPGAVVIDVGINYKEDPSRKSGKRLIGDLHYESVSKVASYITPVPGGVGPITVSMLLQNVLESAKRFQSLSHSKIISPLPLKPLNPVPNDFIISKSQTPKNIQTLAKEIGIFDNELEIYGNYKAKVSLDILDRLKYRKDGYYVCVTGITPTAFGEGKTTVSVGLAQALGAHCKKLTFVCIRQPSQGPTFGIKGGAAGGGYSQVIPMDELNLHLTGDIHAVTAANNLLAAAIDTRFFHEETQSIKALYSRLVSKKDGKCNFSPIMKKRLQKLGIDKTDPNDLTNEEIEKFARLNIDPKTITWQRVLDVNDRFLRKITIGKNPTEKGLERTSGFDISVASECMAVLALANDIKDLRKRLGDMIVATSQSGDFITADDIGVGGAMAVLMKDAIKPNLMQTIEGTPVFVHAGPFANIAHGNSSILADRIALKLTGIENDETREKDAGYVITEAGFGADAGLEKFFDIKTRTSGLQPDAVVLVTTVRALKLHGGGPEIVSGKPLDNVYFTENLELVRKGCCNMIRHIRNIEKYGVPIIVAINKFHMDTQSEITIIQEEALKAGAVDAVVSNQWALGGAGSIELANAVQYACQKVPKNFKFLYDLNTSIIEKIEIVAKEIYGADGIELSELSKEKIKQYTEKGFGNLPVCIAKTQYSFSHDPKLKGAPTGFIIPIRDIRLNAGAGFIVPLLAEITTIPGLPTRPAYYDVDINTETHQVEGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7PI27</accession>
    <name>M7PI27_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_01398</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873333.1">
        <property type="nucleotide sequence ID" value="XM_007875142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PI27"/>
    <dbReference type="STRING" id="1069680.M7PI27"/>
    <dbReference type="GeneID" id="19895095"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01398"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001872_1_1_1"/>
    <dbReference type="OMA" id="VKQIKLV"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06627">
        <property type="entry name" value="STKc_Cdc7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000583">
        <property type="entry name" value="MAP3K epsilon protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000946">
        <property type="entry name" value="Probable serine/threonine-protein kinase DDB_G0284251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361:SF433">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="11"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR10119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1218" mass="138317" checksum="47A7F5927550D8FD" modified="2013-05-29" version="1">MTTDNKKLSVYHLGDCLGKGAFGAVYRGLNPNTGETVAVKQIKLHNIPKTELKVIMMEIDLLKNLNHPNIVKYHGFFKTADALNIVLEYCENGSLQSICKTFGKFPENLVAVYITQVLHGLLYLHDQGVIHRDIKGANILTTKEGFVKLADFGVATRTSSLSDFTVVGSPYWMAPEVIELSGATTASDIWSVGCTVIELLEGKPPYHKLDQMPALFRIVNDEHPPLPEGSSPATRDFLMQCFQKDPNLRVSAKKLLKHPWLVKQGRLYDKIVPQSAAKYDDVIKSVQQWNAALKSPDIGTIRKSSIYSTQPFKPTDFYFSANETKELTLKHVSEINRLKTEAFRSPDDSITSNWDNDFITDISPSKLLLSDSYCRATGLNNKVSYKNISEIPYRFKEISSKSLDNWNKDFEGGLTLGSFQKLKISVNEDIEDNMKTIRPLKNVKYNDSTNVSSSNTELQLSDECSKDIPSFHYEITEDYSDLVPENEYSFAQKVDQYKRDNLTNLRLFHPNDIKMLSQSSHPLKKSRFCQNSSILTTENNSFSAANCSTEISQYIEHDDDETDYSNIFSHLSRRDEQGDLSYSDTLMLNTKLSYNSWFCDDASDEDDLFLQINEGFEEMDLDANIAREQQARTAERVISIVDSLKVDQDESSLITRCSDLMSILSESSDFKANVIAASGLLPILEILDVCQRRDLILQLLKIVNLVMEGNIEAQENLCFIGGIPVITKFASKKYSYDIRIEAAFFVKMLCHSSGIVLQMFLSCRGLNVLVEFLEEDYEVQKDFVWIGINGVWSIFEAQGSSPKSDFCRIFAKSGIMDPLSLVLHHVLNEEQTELNRMCSERIVKIFLLFSQADNTVKELITTRGVIKRILKDLFKMPLSLLINMLKFVKNLSTVPATLDTLQNANTIEILTEILASHEGVSNSKDIYNQVLNTMYNLCRLSKSRQEEAALSGVVPLLQNIVQKVPILKEFALPILCDLAHASKVCRKVLWQNGSLEFYLSLLSDPYWQANALDAILVWFQDDSGKLEEYLLRPSSILAIMEAFSTAMANSFENLLECLHKLLRLSQRIACALAQPKFFEKLVRRLQHQKPIVRLNLLRVLRSICNAHPSKQALITQYGLYDIIEKLSRQDTAVLVRELAKDILNQTWMDNSESSKLSNSYNSECSNQQVSTVWFDANDRLIYDRLDELSSSRGIFDNDIVCKTPKTEVHRRHNIQKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7PIF2</accession>
    <name>M7PIF2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucosidase II subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_03597</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873601.1">
        <property type="nucleotide sequence ID" value="XM_007875410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PIF2"/>
    <dbReference type="STRING" id="1069680.M7PIF2"/>
    <dbReference type="GeneID" id="19897284"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03597"/>
    <dbReference type="eggNOG" id="KOG1066">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000631_7_0_1"/>
    <dbReference type="OMA" id="TVHQPLW"/>
    <dbReference type="OrthoDB" id="3237269at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106407">
        <property type="term" value="F:Glc2Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033919">
        <property type="term" value="F:glucan 1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070880">
        <property type="term" value="P:fungal-type cell wall beta-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06603">
        <property type="entry name" value="GH31_GANC_GANAB_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000023">
        <property type="entry name" value="neutral alpha-glucosidase AB isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF54">
        <property type="entry name" value="BCDNA.GH04962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004083199" description="Glucosidase II subunit alpha" evidence="11">
        <location>
            <begin position="23"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="13">
        <location>
            <begin position="85"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="12">
        <location>
            <begin position="370"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="14">
        <location>
            <begin position="704"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR10234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="939" mass="109556" checksum="2291A1E65F101355" modified="2013-05-29" version="1">MKYSKALTFIFNCCLFFISSLAVDHKSFKTCDQSSFCKRNRYLADEGTPKDKYIFDNSKLVLKDGILEAVVLKILEINKQTIHLPISISFLKTGVIRVKIDELQRQTGNIDITNDAKVRKERYNETEKWTIISSLEYDKTIQNYVEEPGMTIVNYGPDNIYEMRITHDPFKISFYKDKNLEILFNEYGYLNFEHWRPKPLVNEKSENSHEFNMWEESFNGIHDTKPLGPESVALDITFVDYKHVYGIPEHSSSFSLKETRGENKSYNEPYRLYNTDVFEYEFDSPASLYGSIPFMYAHKKNSSVSIFWMNPADTWIDIEKKKYNAQDSINMSTKTHWISETGLIDIFVFLGPDHNSIFKHYGELVGYTILPNIFSLGYHQSRWNYLGEEDVFYIDNRFDEYDIPYDALWLDIEYTDGKAYFIWDKDYFPSPTKILKKLDSKKRQLIIIVNPHIKKDEEYYAYKEMKDRELFVKTSKGDVYEGNCWPGSSIWIDVISEKGAEWWSDKFQYEVLNFSFSNLHIWNDMNEPSVFNGPEYTIHKDAIHSGGWENRALHNLYGFVVQYYTYSGLLRKSNKKVRPFILSRSFWASTPRIGAIWIGDNDSSWEHLRASIPEVLSLNIAGLSFSGADVGGFFGNPSNELLTRWYQAGIFYPFFRGHSHIDTRRREPWTIPSSYTSIIRNSILIRYQLLPTWYTAFFLASTTGLPVLRPQFLKFPDDEDGFSIDDQFFLGDSGILVKPVTSEGATEIDVYFGDDEPYYDYFDFSVHNGKGYKTFSCPLEKIPMFIQGGNIVVRRDRIRRSSLSMMNDPFTIIVALDNKGNAKGSLYLDDGVSFDNLDGFYIYKEFIFSSDNLTFVSYDLYNSKNSQEYSKRIKNLRIEKLIILKSDNTIKEISTAKVIQGKDTWEVEVTVTRTNCEKTQIIFIRDPKLSITENWQLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJ12</accession>
    <name>M7PJ12_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">6-phosphofructo-2-kinase</fullName>
            <ecNumber evidence="1">2.7.1.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_03608</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Synthesis of fructose 2,6-bisphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15653"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.105"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.105" evidence="1"/>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873310.1">
        <property type="nucleotide sequence ID" value="XM_007875119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJ12"/>
    <dbReference type="STRING" id="1069680.M7PJ12"/>
    <dbReference type="GeneID" id="19897295"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03608"/>
    <dbReference type="eggNOG" id="KOG0234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006383_0_2_1"/>
    <dbReference type="OMA" id="VKTHVFH"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000644">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF39">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE_FRUCTOSE-2,6-BISPHOSPHATASE YLR345W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00052669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="447" mass="52359" checksum="410075FC42819C3A" modified="2013-05-29" version="1">MNKNTEFSTSEQPYIAQTEKFFHGGKIAIIMVGLPARGKTHLSVSICRYLRWLGVKTHVFHLGDYRRKNLKKGEVLPEDYFYANPSEKTKEFRNSVLSCCKIDIIKFFDSEEGQVAIYDAVNPRISDRQGLATFFAEKNIQPLFIESLCDDPDIIEENVRNLKISSPDYAGWKPEDAVKDYFLRIKNRIPIYETIVEHDLSYIKIININQKLIINNANIGYLHSRIIFYLMNLHIKPRVIYFARACNSLHDSNFKKEDDFSDRKKYEYATALVNTLLKHRETLQNQLTSDKNKEIKDLMIWTPISDKICYIADLLRNNGYIIYQRPQLRQINLGMVEDMTLEEIKEKYPLEIRCFQENPNTHRFPRGESMHDLRHRLEPVIFEIEKESNDILIVAHISVIKLLYAYFMNTPTDKIPFLNLPKNQIIKIIPGAYICTETRIHIPITLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJ57</accession>
    <name>M7PJ57_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01201</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873118.1">
        <property type="nucleotide sequence ID" value="XM_007874927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJ57"/>
    <dbReference type="STRING" id="1069680.M7PJ57"/>
    <dbReference type="GeneID" id="19894898"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01201"/>
    <dbReference type="eggNOG" id="ENOG502RS0A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_419265_0_0_1"/>
    <dbReference type="OMA" id="KFSPSPW"/>
    <dbReference type="OrthoDB" id="10069295at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048401">
        <property type="entry name" value="SLS1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032741">
        <property type="entry name" value="Sls1_KH-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048400">
        <property type="entry name" value="SLS1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14611">
        <property type="entry name" value="KH_SLS1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20778">
        <property type="entry name" value="SLS1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20776">
        <property type="entry name" value="SLS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLS1 N-terminal" evidence="3">
        <location>
            <begin position="76"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="SLS1 first KH" evidence="2">
        <location>
            <begin position="160"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="SLS1 C-terminal" evidence="4">
        <location>
            <begin position="314"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR10489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="654" mass="77991" checksum="8D50B73056A70E31" modified="2013-05-29" version="1">MYFLFNLVDIILNIMSKFHKNDIFSDFFPKEKSIIVLRKQKSKIQFNSDPLIQPLEEKSLELLSRKLIYDCPDGMDDTSINEIDSMKPSHVFVSLDLFNQIIRNMKFSFNKKQIQKYAKLNGLKNLSRCNRDQLIEAILKEIWGLKISDNICSDILMVKEIYVNKRDLFFMTRSNKYVLQQWARNYQAKIYIDFDKLFLRVEALKSNIERIKERIAQMAKDIKIEDIDIKCFSMPEYFNDRHISEISFLSGAFIEKIDINRIRITTLRNELEPLDNAKILICMSLISNDCKNYSLIYNNSPNNNSFYYFGEKFSLPWFLRRQKWARWKTIIYRNENKFFSKDENVKKLLENEYYIMIENGFLKLNSNVILMLYDIRKFLDIHMVYSNNFSKVKVQYDIIFGYVLHDYSLENIYKQFSIFQLRQYFEKNVKNDEIRRIFCSNISRASSFIHKLKSGYKDEFLDKFYKKILRLKFVPSPWVHSNLDNSYIEIDLELDNKGNICNTMVKYISCESILDVLLPECGSDLRISRKTFSFLDPNNKLLMAYLNMIQIGITSNKLRISSTLSVEIPSESEDVSKAKEYILIRMEYINQFDFKFNKFLLRFLIIEENMKTRRAELKLLSSEFNIMNSTITKLNDQDWKDFINDALIILNELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJS9</accession>
    <name>M7PJS9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDCD5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872769.1">
        <property type="nucleotide sequence ID" value="XM_007874578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJS9"/>
    <dbReference type="STRING" id="1069680.M7PJS9"/>
    <dbReference type="GeneID" id="19894557"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00859"/>
    <dbReference type="eggNOG" id="KOG3431">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122978_2_1_1"/>
    <dbReference type="OMA" id="YISESKH"/>
    <dbReference type="OrthoDB" id="10252486at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.140">
        <property type="entry name" value="PDCD5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002836">
        <property type="entry name" value="PDCD5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036883">
        <property type="entry name" value="PDCD5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840:SF0">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01984">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015730">
        <property type="entry name" value="TFAR19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46950">
        <property type="entry name" value="Double-stranded DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="10743" checksum="2D6672EAA2254DCB" modified="2013-05-29" version="1">MHSSTQESSEDQSSRYATLSRLMEPAARDRLTRIALVHSDRARDVENILLRKAQEGLLQQKVSESNLISLLNQLKDEKKETKIIFNRQAFDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7PK55</accession>
    <name>M7PK55_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit beta</fullName>
            <ecNumber evidence="13">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_00966</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="13"/>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872879.1">
        <property type="nucleotide sequence ID" value="XM_007874688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PK55"/>
    <dbReference type="STRING" id="1069680.M7PK55"/>
    <dbReference type="GeneID" id="19894664"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00966"/>
    <dbReference type="eggNOG" id="KOG1350">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022398_0_2_1"/>
    <dbReference type="OMA" id="SMEEGGW"/>
    <dbReference type="OrthoDB" id="14523at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF71">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039072">
        <property type="entry name" value="ATPase_subunit_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="198"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR10819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="528" mass="57837" checksum="B5B0EF38D048ED67" modified="2013-05-29" version="1">MFFARKIRPFFHRRFLALRIKNENIRQLIQLKAQKIECLSFLNARFITTDTTAQNLPVGRVKAVIGAVVDVQFDTEELPKVLDALHLDLPDGKRLVLEVSQHLGERTVRTIAMDGTEGLVRGQKAKATGGPIKVPVGPGTLGRIMNVIGEPIDERGPIKAVKYNPIHTEPPTFSDQETTPSLLVTGIKVVDLLAPYARGGKIGLFGGAGVGKTVFIQELINNIAKAYGGYSVFVGVGERTREGNDLYHEMIQTGVIKLDGESKAALVFGQMNEPPGARARVALTGLTVAEYFRDEEGQDVLLFVDNIFRFTQAGSEVSALLGRIPSAVGYQPTLSTDMGGMQERITTTKKGSITSIQAVYVPADDLTDPAPATTFAHLDATTTLSRSISELGIYPAVDPLDSNSRLMNPRIVGEEHYRIASEVQLILQSYKSLQDIIAILGMDELSEADKLIVERARKLQRFMSQPFTVAEVFTGLEGRLVDLKDTLRSFKEIIEGRADDLPENAFYMVGDIDEARAKGKKILQEIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7PK92</accession>
    <name>M7PK92_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YjeF N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872929.1">
        <property type="nucleotide sequence ID" value="XM_007874738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PK92"/>
    <dbReference type="STRING" id="1069680.M7PK92"/>
    <dbReference type="GeneID" id="19894714"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01016"/>
    <dbReference type="eggNOG" id="KOG2585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026194_0_0_1"/>
    <dbReference type="OMA" id="YISTGRH"/>
    <dbReference type="OrthoDB" id="10030313at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612:SF0">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="2">
        <location>
            <begin position="320"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="570" mass="64019" checksum="2034B3A85DEB35D6" modified="2013-05-29" version="1">MEKQFIGLKVEVILRDNTIVQGQMTDIDAVNRCLFLKNVYCKTTGKFVPEMQIEGVNIKDLNFITSFDVKKKKSFTFIDPAIISISNNLSNMTTKESSKKSKKDTTLPSLSSRLHKNSKSYGLCNYRSRDSSNIHAYNMKNMHKRDRSYMNALQKESPQFKHTNHDNWVNEDVNRYRDEEFDFQGNLGRFDKHKVFSEIRKSNLISSTSLSASSNCLSKVELSSDVAATNLVINKKNASLNESNCFLKMNGNENTPSSGFPSSSHLSSDSYDEKGVYQQKLKNQRSNNQHTLSNLDKISRRNKKIRNTKNNLECPCIKSSKMIEAEYISTFDTGVSNDAIVENAARGISFLVSQLLDFSRFSQKKSISPAIIILAGNNQTGIYAIASGRQLCNHGVKVMIVVLEENPSKRILSYLKGFSNAGGKIVSSEELFRAIKSFSVLPGLIIDAIFGCHCSFTDIMDDNLRNRICTLIDWANQYQSDILSLDLPSGLDIVTGAPLASSHFIQSKWILSLGIPKTGLLFALKSKRVPKELFLADIGIPQKVWKKVGISKRARSLWAGQDWVIKLDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWV1</accession>
    <name>A0A0W4ZWV1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ER membrane protein complex subunit 7 beta-sandwich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_04339</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="KTW32848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613329.1">
        <property type="nucleotide sequence ID" value="XM_019757851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWV1"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZWV1"/>
    <dbReference type="GeneID" id="30671610"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04339"/>
    <dbReference type="OMA" id="FTFGMPK"/>
    <dbReference type="OrthoDB" id="27095at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019008">
        <property type="entry name" value="Beta_sandwich_EMC7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039163">
        <property type="entry name" value="EMC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605:SF4">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09430">
        <property type="entry name" value="EMC7_beta-sandw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006933919" description="ER membrane protein complex subunit 7 beta-sandwich domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 7 beta-sandwich" evidence="7">
        <location>
            <begin position="40"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KTW32848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="235" mass="26785" checksum="2A93C764B110C294" modified="2016-03-16" version="1">MKFQIFYIFLVFVGLVLSIELKGSIVPNTYLSSPRFLPSSTIILLSSANILKKTHPTSKGNFSIKNVTEGSYLLEVVCSTHLFDPLRVDISLIKKTQTDELNLSSEKDSETSSLERIQVYKVYRGNKWDDFGPKMPYPIQFSPIGVQSYDVKKDSSKIQLLKNPIVQLSIITVTILFIFPRLISTLDTEQLMEYQRTHAQKKGKDYPNKAQSFDMASWLSNQTLKSSESQKDKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWX8</accession>
    <name>A0A0W4ZWX8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RecA family profile 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_04317</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="KTW32874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613351.1">
        <property type="nucleotide sequence ID" value="XM_019757832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWX8"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZWX8"/>
    <dbReference type="GeneID" id="30671595"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04317"/>
    <dbReference type="eggNOG" id="KOG1564">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2971">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PCLGLQW"/>
    <dbReference type="OrthoDB" id="1861185at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042275">
        <property type="term" value="P:error-free postreplication DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030491">
        <property type="term" value="P:heteroduplex formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007533">
        <property type="term" value="P:mating type switching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000707">
        <property type="term" value="P:meiotic DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903112">
        <property type="term" value="P:positive regulation of single-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071140">
        <property type="term" value="P:resolution of mitotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090656">
        <property type="term" value="P:t-circle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19491">
        <property type="entry name" value="XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047348">
        <property type="entry name" value="XRCC3-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46487">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46487:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="7">
        <location>
            <begin position="71"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KTW32874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="368" mass="42299" checksum="C2A19C1945268058" modified="2016-03-16" version="1">MDLWQTCPKIKCNEKTYIALEKAKLSTLDLLTLDPLDICKKTSIRMAEIEELIDKIIHECIPKKKEYDWDRIEFFTTGDKIIDEILSGGIPLGHVLEIVGESGTGKSQFCMQLCLTVQLPQELGGLEKNAIYISTESGLSTKRFFEMAKSFEKRLKIHYPSINININELGNRVYCITCVDLEEQNHILQFQLPIAMERYNIGLVVLDNIATHFRAEYDVSNIYYQTDKMSNPTIKSGLIDLVNRSRDLVRLGAHLRLLAEKHQCAIIVINQVSDKIKKDTMTLFDYNYQGAWFQGWKHHEYSCKVPSLGFVWSNNIHARILLLRSILCQETCTQNRALRVVFSPFCAPTQIDIDLTHEGVFSTQTTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZX13</accession>
    <name>A0A0W4ZX13_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_04282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="KTW32913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613384.1">
        <property type="nucleotide sequence ID" value="XM_019757802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZX13"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZX13"/>
    <dbReference type="GeneID" id="30671573"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04282"/>
    <dbReference type="OMA" id="SCYIKKN"/>
    <dbReference type="OrthoDB" id="5374349at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KTW32913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21871" checksum="12BBF95858E6FAD0" modified="2016-03-16" version="1">MKDRVRSAPLSRVYFEKTGFERIKKNVNLSLKKRPFDVHKKWVHDLYNEKNESIALNEEIHKKLASNPLFQRLNCKKDLEKDDSLAKNPLYSRLNGSQTVIKGSAQGKNSWTIKGISGATTVIICNLVEGTSAEDVKTSLASLGHIQACSVYKVNHGALVQAEVTFSLRSEANTVVEKLNQAIADGNVLTVYIKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZX22</accession>
    <name>A0A0W4ZX22_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_04285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="KTW32916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613387.1">
        <property type="nucleotide sequence ID" value="XM_019757805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZX22"/>
    <dbReference type="GeneID" id="30671576"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04285"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KTW32916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="75" mass="8987" checksum="6F413C09B07692FA" modified="2016-03-16" version="1">MINGIDFFLFNYDVLESYCNFISNDCKNEILNSSAFSINKLFMIYGNINHILKLYFRLRTTFLKIYKIINIILIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZX38</accession>
    <name>A0A0W4ZX38_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">DNA repair protein RAD5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PNEG_04255</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="KTW32933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613402.1">
        <property type="nucleotide sequence ID" value="XM_019757779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZX38"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZX38"/>
    <dbReference type="GeneID" id="19894283"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04255"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KVEPWSN"/>
    <dbReference type="OrthoDB" id="2801544at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16572">
        <property type="entry name" value="RING-HC_SpRad8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="365"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="739"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="826"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KTW32933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="993" mass="114130" checksum="B7A3A957FC10CF13" modified="2016-03-16" version="1">MMNRPEKRPKVNSFYDHEDRVNERGKMEAIIDELKVIIGHNVEIEILEYLAQTSKGNIELALNMYFDKTWEKKNQKEQKYINQESLSTKSWYLKYIGSFGMEGWANVSGTGFLSAGEVVLLKKQDKINEKTKSRQFFPESVSRKRNSRQNLSRIIRFCTEKGIEIGRIPQESAIHISTLLEFKTCSFTASCIYAPDKIKIGDKILLQIACFIHRQAFTSMKEPLFSREDNIYKVSMTEEIREQHRQAILWLLTKVGLEPDDSKTPDSKTIFKEVIKASKNTGPILSKMGYLDPFGENSSDLEEESKELEKEQINFIYKNTKSYDPNMKEMLPSSSFNLELKLDFGNSDNRFYVNPYSGKLTLEFPRADQGFCGGILADEMGLGKTIEILSLIHSNKPVASLNSTPFIINSNASIQSCRTTLVIAPLSLLDQWRSEAEIASKPNSLKIQIYYGTDKSIDALVQCQTSNQPDLLITSYGVVLSEWSQMTTNNKAFFNLFSIDFYRVVLDEAHYIKNRLSKTAKACSSLNAKRRWVLTGTPIVNKLEDLFSLIHFLKIEPWGNFVFWKTFITIPFESKDIPRALNTLRMIFENLILRRTKTTKDIHGNLIIALPSKEIMTKEIILSLKEREIYDFIYTKAKQAFIENSAAGTIFKNYITILTMLLRLRQSCCHPSLIKHGDKSDFLDLPFDKDIKNSINTDDIIDLKDLIEPFCNQDIKKQNTDAYRTCVIKSILEKTQNECSICSASPIVEEAITSCWHMACKSCLKKHIEFQKSHNKKPLCHICRSPIDEQNIYEIIRKGTQGVADNNSRIELRKFTSISSSKLDALIKQLFALKMSDPYAKSIIFSQFTAFLDLVEVFIKRDNFEFLRLDGGMSMKERSIVLEKFRTEKKGLILLVSIKSGSVGLNLTAASWVFILDPWWNFGMENQAIDRVHRIGQTLPVKVVRFIVKDSIEEKMIEICKRKLMLADISVMEYQSRDDVTKQRLEELQALFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M7NHR5</accession>
    <name>M7NHR5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_03551</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875644.1">
        <property type="nucleotide sequence ID" value="XM_007877453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NHR5"/>
    <dbReference type="STRING" id="1069680.M7NHR5"/>
    <dbReference type="GeneID" id="19897238"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03551"/>
    <dbReference type="eggNOG" id="KOG0598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_52_2_1"/>
    <dbReference type="OMA" id="SYAMGTT"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031138">
        <property type="term" value="P:negative regulation of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904828">
        <property type="term" value="P:positive regulation of hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060963">
        <property type="term" value="P:positive regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045945">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901494">
        <property type="term" value="P:regulation of cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047484">
        <property type="term" value="P:regulation of response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090153">
        <property type="term" value="P:regulation of sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11651">
        <property type="entry name" value="YPK1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000116">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2" evidence="11">
        <location>
            <begin position="86"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="273"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="535"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR08113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="670" mass="77276" checksum="4EC8203CD8BAEACA" modified="2013-05-29" version="1">MPEFTKSLFFLSKFNNKICNINQFKSNQLIHESSNSQLSSEASNDFAFKESEKQSSSNSAKVSESVFYNNDNSSLKNTQSSLNLSTLCNTQESPSALSVESPKGRLIIRIIQARNLKVKSIDAEPYVICTFENNEFISRGPVMDHNEPMRGIAIPKSHHSSTYLHNTYENGLVTRKNSFSNVIYTANNPFWMYQVIFDVIDLKSNIDINVYDRKNHGSFLGHVQIKPIFIHKKETKHWYKLETLEKEDENIAEIHLEMIYEQINKRHYGPDDFEILKLIGKGTFGQVYQVRKIDNNRIYAMKVLSKKTIVQKKEIKHTIGERDILVRTTISDSPFIIDLKFSFQTPTDLYLVTSYMSGGELFWHLQKEGRFPEPRAKFYIAELILALEHLHNHDIVYRDLKPENILLDANGHIALCDFGLSKANLSSNSTTNTFCGTTEYLAPEILLDDSGYTKLVDFWSLGVLVFEMCCGWSPFYAEDTQQMYKNIAFGKVRFPKNILSLEGRNFVKELLNRNPKHRLGATRDALELREHSFFHDIDWDALLKKKIPPPFKPVISGESDVSNFDLEFTSAPIQKPENNIHASTPLSSTMQAIFKGFTFVDESSFDDRFEKSFFKQSIFMDQDQNLNYCNIDDSENYHTDNNYKNDSQINDDRTMSIVQTEDEIFQGNFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NIE8</accession>
    <name>M7NIE8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_03183</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875246.1">
        <property type="nucleotide sequence ID" value="XM_007877055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NIE8"/>
    <dbReference type="STRING" id="1069680.M7NIE8"/>
    <dbReference type="GeneID" id="19896870"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03183"/>
    <dbReference type="eggNOG" id="KOG2171">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003794_0_1_1"/>
    <dbReference type="OMA" id="PKRFVQE"/>
    <dbReference type="OrthoDB" id="543373at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007088">
        <property type="term" value="P:regulation of mitotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060188">
        <property type="term" value="P:regulation of protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041653">
        <property type="entry name" value="Importin_rep_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040928">
        <property type="entry name" value="Importin_rep_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041389">
        <property type="entry name" value="Importin_rep_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18808">
        <property type="entry name" value="Importin_rep_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18816">
        <property type="entry name" value="Importin_rep_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18829">
        <property type="entry name" value="Importin_rep_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TOG" evidence="8">
        <location>
            <begin position="361"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1096" mass="123930" checksum="D45183D8858D78CA" modified="2013-05-29" version="1">MSFIEQETALALKSLLSSLKHTDNEIRMKAEASLHEQWIAHEPEILLVGLAEQVNMSEDSSLRSFAVILLRRISFRPISLGNDAKETMVWNMLSQDGAKKVQSLLLESFTKENDENVRHKIADTISEVAHTLYEENVAWPELLYILSQCTKSMNPGQRESTFRIFASIPEILKKEDTNMIKQVFQLSLQDDDIKVRLSSLKALSSLFTSSNSDSHELVSLLPLMLNVFPPLLQSHDGDSFTSALTSLIELAEIYPKIFKPYFGTVVQFFVESLKNRDLGNSARQSSLEFLVTFSEGAPGMCRKDENYAKSVIYECLSFMTEVGMEEGDKLDEWLETDDLDFAESELNHIVGEQAMDRLARKLGGKILLPIAFQWLPSLISSQNWHQRHASLMAISAIAEGCEKIMKAELGRVLDMVLPLLKDTHPRVRWAACNAIGQMSTDFAKTMQKNFHKQVLSALIPVLEAPEPRVQAHAAAALVNFCEEADNKVLEPYLDDILNRLLYLLKNQKRYVQEQAITTIATVADAAEKKFIKYYDSIMPLLINILNQAKQKEYKLLRGKAIECVTLIAIAVGKEKFSSNSNEIIQTLGSIQSTITEPDDLQSSYLIAAWGRICKVMGKDFIPYMGAIMPPLLHSAKLKPDFTVLDDDDNHEKYLEEDGWEFISVQGQQIGIKTSALEEKCIAIEMLLCYAIELKAAFEPYVEEILTDIVIPGLRFYFHDGVRSASIKAVPQLLSCIKEAHSENNSKLISIWDTLLDKIINLINTESAIDVLTELYQCLYESIDVVGNNCLSPEKMDTFITSSESQLQDYISRVQKRYHDHQTDEANLEDEDVASAIVLDDDLLSEMSKTFHIIFKRHRLSFLPHWERLLPYLDEFANNQHDANARQWAICVMDDLIEFTGPDAWKYKDHFLKPLSNGIIDDSPGVRQAAAYGIGVAGQYGGEPFSMICSASLPHLFRCFERPDSRSEDHIYATENICCAIAKILRFNSSKISEIDKAIELWVKTLPVTHDEEDAPYAYAFLVELIERNHVAVVSQPALVIDAIAQALESEILQGHILDRILNSSKIFCRKLSQEQINMIISNMPLERQQVMASYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NIL2</accession>
    <name>M7NIL2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trehalose-6-phosphate synthase</fullName>
            <ecNumber evidence="6">2.4.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">UDP-glucose-glucosephosphate glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_03259</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="2.4.1.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.15" evidence="6"/>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875326.1">
        <property type="nucleotide sequence ID" value="XM_007877135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NIL2"/>
    <dbReference type="STRING" id="1069680.M7NIL2"/>
    <dbReference type="GeneID" id="19896946"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03259"/>
    <dbReference type="eggNOG" id="KOG1050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002351_7_1_1"/>
    <dbReference type="OMA" id="NRTIWPL"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000007">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000035">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012766">
        <property type="entry name" value="Trehalose_OtsA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02400">
        <property type="entry name" value="trehalose_OtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF106">
        <property type="entry name" value="BCDNA.GH08860"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="495" mass="56840" checksum="001FD85F734B0DB5" modified="2013-05-29" version="1">MLKECEKSEINHEDTRLLIISNRLPITIKRKGKGEYEFSMSSGGLVSALSGLKKSIYFSWIGWPGVEIPESEQKYVISKLQKEYNAVPVFMDNELADRHYNGFSNSILWPLFHYHPDEIRFDEPTWEAYREANGKFAKLICSIVQEGDLIWVQDYHLMLLPAMLREEIDEKYNIKIGFFLHTPFPSSEIYRILPVRNEILHGVLHCDLIGFHTYDYARHFLSSCSRILNLHTLPNGVEFNGKLVNVGAFPIGIDPDKFTEGLKQPKVIERIQALEKKFENIKIIVGVDRLDYIKGVPQKLHALEFFLTEHPEWIGKVVLVQVAVPSRQDVEEYQNLRAVVNELVGRINGKFGTIEFMPIHFMHKSISFDELIALYAVSDICLVSSTRDGMNLVSYEYICTQQKRHGVMILSEFAGAAQSLNGSLIVNPWNVTELAGAIYDAITMPEDLRKSNHEKLYRYVNKYTSSFWGQSFVNELKRISLLPKNTMDSVLNPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJF9</accession>
    <name>M7NJF9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sister chromatid cohesion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02921</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SCC2/Nipped-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874963.1">
        <property type="nucleotide sequence ID" value="XM_007876772.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NJF9"/>
    <dbReference type="GeneID" id="19896608"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02921"/>
    <dbReference type="eggNOG" id="KOG1020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000901_0_0_1"/>
    <dbReference type="OMA" id="SANFKDR"/>
    <dbReference type="OrthoDB" id="418242at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090694">
        <property type="term" value="C:Scc2-Scc4 cohesin loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061775">
        <property type="term" value="F:cohesin loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140588">
        <property type="term" value="P:chromatin looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071169">
        <property type="term" value="P:establishment of protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23958">
        <property type="entry name" value="SCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026003">
        <property type="entry name" value="Cohesin_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024986">
        <property type="entry name" value="Nipped-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033031">
        <property type="entry name" value="Scc2/Nipped-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704:SF18">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12765">
        <property type="entry name" value="Cohesin_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12830">
        <property type="entry name" value="Nipped-B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Sister chromatid cohesion C-terminal" evidence="8">
        <location>
            <begin position="1358"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1655"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1664"/>
            <end position="1677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1682"/>
            <end position="1706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1714" mass="196508" checksum="0C54417BE62663AF" modified="2013-05-29" version="1">MELSSNQKPDISGRKHRCPGIPSEITEAFQYSPLASLVSLEPLLQTIPQLKVKSCVESLLKLSDREKQMLDMQLESCNGLGPDKDSKMPSSVLQEILEPLKGIQISKWSFKAPGKIERYMTENQAEPSRLDVFSRVLVDKCTVDIIYPSPVTPTAHTGRLKEEFISDKEGFFEKTTVGFDSEEIVEENVQKESISVQPLTPQSNIIPCTPTSKNNTRKMQLSGGCTNKSKRFVDISEKDVYPIAVDDQLKEESAVDQLQKLIRFIFEAEDAMESDGSHLEVEESYISCWCNGTVSFDGLCLNMEMLSKLDLCIRKVCTMGLINTLPIDLLLRFQKICARSIDETQIITLTKQSFETNSYEENLSIITKIGISVYSMTILMRILTSEQLSKQLYSEEILIDMAYFLKSTLDNVIYVLIDFDVSKKSDALKFKKSLNMIFYNVINIIEYFCHLISLIEIPDGVITRLEFLSIPAIFVENSVSIKDQLFNSQGIEALKVASMGMIQLIHTKYPDQRTFILDEILTGLVKLPINKHQARRYKLIDGKSIQLISALIMKLVQSCASSYKSDKGMNIYEFLEKDANDMRNNIDYAMNSKSSASELLEMIFDASSQFMDSVTANANHVVSFLLSKAMKISKITNDFSHKILLDIFIEDLLLVLPLPSWPSSELLLKLIVTKLLNYLENDKESSHIKGLSLDFLGIIASKIRLFFKNSTDFSNHLFKSDILSRISSILQAGNFFLEKLDDLKDLFKLHLLIIESLNLRNIEESKDQNILQYLWLRWIYFIRSLRQKYTLNNSTVSDDFASEILKLVYYIDFSDNKMIEDDSLSDQIYRLYLLNLSIYSIYQLFDAILSRILRCLDSNQISIRTKALRSLGLIVNNDSSILSNIGVRQHVAARIADISSQVRDVAIDLVGKYAIFQKEIGQQYYSVLSERIADTGLSVRKRVIRFLKDFYTISDTQEIQIDIGRRLIQRLCDDEDSIKDLSAKTIEDIWFSVSDDQNEGNIALIKFKKIQTEKILVLQSIIETLRDEDRFSFKVFLQKISKSKNMDSSNFILTSSISLMFDILLEYHQNQDMKMLEKCLNTIVIFAEACPKLFSTDQLISIQPYLNGLNSPQEQVIFFYTVIIYRNVLPYIPSISKKFLNDLQKMLLSQLTRLPAKILNEVVPCLSVLANLFGDYERVGKIISSCIKAIEPYKIILQNKKQISDDKKLILLLLLLGLFGRHCDLDNHFQDLNVFLKLKPDTSIAKFLIKTISIFCSLSSNIHISVQKVALHSIGIICISHSKFFLCDQNLEIMSNVFEGTSIELQNTLLLVFYDFLSLEEKEFRVFEKNNHSIKNKIADVNILTGEMKKFENDGTSISLIQRYLPQILEMSMNEDTALSITAVKILEIITNNGIANPRTCIPTIIALQASPNKFIKDMAMKIHLGMHEKYESLIEGCYIDGIKMAFQYQVRMKCFTSNDSNLLFVFPYNIIKQNRQSRKKFLISLTKMLDIDMTQISLHENIIFSRFLVQNMASFEYSTIEEIQYIIYIADRILSTTGISLHQRIEIEEFKFQDHDIIKIAIASVQMLALVLLKKYLKESYALTEQKCRSFDPNKTGNSKDTKLSSKLRDVPLNLDSIPNITDSMITRDVAEKIIQNFYDVISNDDTSYTEFIETNEHKQTEENETETYNDDDEIDELVKTKKKHKKKLKRKGKSFRNGISKKKYKQDISDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJN5</accession>
    <name>M7NJN5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PROP1-like PPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02981</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875028.1">
        <property type="nucleotide sequence ID" value="XM_007876837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJN5"/>
    <dbReference type="STRING" id="1069680.M7NJN5"/>
    <dbReference type="GeneID" id="19896668"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02981"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_416844_0_0_1"/>
    <dbReference type="OMA" id="ESSAIWA"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140053">
        <property type="term" value="P:mitochondrial gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033443">
        <property type="entry name" value="PROP1-like_PPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938:SF35">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938">
        <property type="entry name" value="RESPIRATORY COMPLEX I CHAPERONE (CIA84), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17177">
        <property type="entry name" value="PPR_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="176"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="PROP1-like PPR" evidence="3">
        <location>
            <begin position="179"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="211"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="246"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="283"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="658" mass="77163" checksum="0AE1C4FA91B7C806" modified="2013-05-29" version="1">MFESKFVQKVLLRRRISLENAFACFFSTKNLKSHSKKSTLLNIRTLEKCIAKLRTRLENEEKWRKSDDISFSKKLSENEYELLYKFICKPEHQLPIAIGNDTLSPILVERIKISLEKTASNLTWTEKLSIISSNGGLEGLTTSQVNKMIYSIPSKERCFLTENIFDMMRKASIQPDRLTYDFIMDGYAQVGDVKGALRTFSQMKQYGFAPSVYSYAHLIKAYSKIGDIDNVMLLFKDMKKYLINPNLVIYTTLISLCVQNQLFDEAWKVFDLLKYRSKDVFPDVKTYSLMIYTCALTGEAERANELFREMLSHPEGSLTPTLETYNALISAYASRKDYFYETWRIAKILLDNNTSMDKKTFIALLKGCGKMGDLKKARILVKHIFQKSESLEKVDIYAFQGLFRAYANYIPKKPIRNSENNYTNSKIEEDILALKLDTNMQNDTRNAFFEDILKSVFLKIDLQTSKDVLDESTALMKYIQKNKYPFLDAQLMNSYLSVLINHGSYSIFKNVYENMYYSITIKEEKISDLYLKKFERGPYTYQLGLEAAYKFNDINFARSVWNERNHWRFLIKNQEKNLEEMNIKYNKLHLSELDFNICRMMINNLAKNNLLQEAKYFLISYQNIFSWKTNHLKLLWNKAKQIKDESLMSLILKTTKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NK89</accession>
    <name>M7NK89_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcriptional activator HAP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874854.1">
        <property type="nucleotide sequence ID" value="XM_007876663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NK89"/>
    <dbReference type="STRING" id="1069680.M7NK89"/>
    <dbReference type="GeneID" id="19896509"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02820"/>
    <dbReference type="eggNOG" id="KOG1561">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1390765_0_0_1"/>
    <dbReference type="OrthoDB" id="1097733at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00616">
        <property type="entry name" value="CCAATSUBUNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="158"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="196" mass="23269" checksum="FB2F0366F86D92D2" modified="2013-05-29" version="1">MFKINSKPFNSESLVLLNPECSKQVAIKRSEPYSEEQLIHGNYWNNEMKFYNNEAYFSVKKDERESDNRELQELYPYLPSILLKDVPITSFIEEKDEINLTGKTDISKSSYYDQGSGEPIQINMKQYHRILKRRIARARIQEILGKRDHMKPYLHESRHRHAMKRPRGPGGQFIKNKQSSEEEIMNELQKNNEKMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NKW1</accession>
    <name>M7NKW1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inorganic phosphate transporter Pho88</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874622.1">
        <property type="nucleotide sequence ID" value="XM_007876431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NKW1"/>
    <dbReference type="STRING" id="1069680.M7NKW1"/>
    <dbReference type="GeneID" id="19896300"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02608"/>
    <dbReference type="eggNOG" id="KOG4554">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099163_0_0_1"/>
    <dbReference type="OMA" id="NMDYDKG"/>
    <dbReference type="OrthoDB" id="18139at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012098">
        <property type="entry name" value="SND3_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112:SF1">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10032">
        <property type="entry name" value="Pho88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008756">
        <property type="entry name" value="P_tr_PHO88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="21300" checksum="1A83E6C0C4601A16" modified="2013-05-29" version="1">MSPQITNLIIILGAMQISKKINFDDPEVLFYIRCLCIASNVIIALTYYLCYISIRRKNDLTTLKYIKSSTSMSGQSEQQLVVTTVREYDTIELKKAIKQSFIGACMIAVMHLYFKFSQPLLVQSILPLKTVLEGKIVQLHLWKKSASGELKRPFKKPQGFFGVSLGDDIKTDKKSIEQAEKAGVGAKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NL11</accession>
    <name>M7NL11_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02293</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SHQ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874287.1">
        <property type="nucleotide sequence ID" value="XM_007876096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NL11"/>
    <dbReference type="STRING" id="1069680.M7NL11"/>
    <dbReference type="GeneID" id="19895986"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02293"/>
    <dbReference type="eggNOG" id="KOG3247">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030217_1_0_1"/>
    <dbReference type="OMA" id="HNIESAW"/>
    <dbReference type="OrthoDB" id="73639at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039742">
        <property type="entry name" value="Shq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048696">
        <property type="entry name" value="SHQ1-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007009">
        <property type="entry name" value="Shq1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12967">
        <property type="entry name" value="PROTEIN SHQ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12967:SF0">
        <property type="entry name" value="PROTEIN SHQ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04925">
        <property type="entry name" value="SHQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21413">
        <property type="entry name" value="SHQ1-like_CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR09338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="470" mass="54950" checksum="94FEC06FBA9F2D1C" modified="2013-05-29" version="1">MITPTFSVEQDTDFIYINIHAVFIRTQNVEIYVEENVFIFSATPYYLRLHLPGNVVEDKFSKMSYDISSETVKIKLSKETSGMVFHDLDLISTLLSRSKTSCDKKTTAPIIEIINEKNTQENIQNNSKMTLENGLVSSIDYCTKDTIQDDSTNSLYTEGLIFDWELPQKAPEQNLHLYASYGFNGQYSNYIKSPSDSGNDINEINDPEHSTSTSRSEERILKEDLKFNDEHYMADYIEDDEIQKCLKWKSQEYIILRSLQKNTSLEEKKKKLDTIILTKEEQLEILKLPRKEYIIDNLKSTYLCILSLLFSYAYDARTTQGEPTSESPWTIGKLSPILSCLDMSFSTIRQIVIACTRRALAYPLYRHWGLIQKCWEDVYCSLKLGKRWILKIFLQIRRIFEQGDTYYLYNKLFLDDYSVWIQTASDSVIWSLAHELHHLEIKKDEINWKLEELETTANNIYIEQKKSETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLE1</accession>
    <name>M7NLE1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH:ubiquinone oxidoreductase 30kDa subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02071</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874051.1">
        <property type="nucleotide sequence ID" value="XM_007875860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLE1"/>
    <dbReference type="STRING" id="1069680.M7NLE1"/>
    <dbReference type="GeneID" id="19895765"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02071"/>
    <dbReference type="eggNOG" id="KOG1713">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042628_0_1_1"/>
    <dbReference type="OMA" id="PCRKNRF"/>
    <dbReference type="OrthoDB" id="37721at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.80:FF:000002">
        <property type="entry name" value="NADH dehydrogenase iron-sulfur protein 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase, 30kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004733">
        <property type="entry name" value="PRK06074.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="Nqo5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase 30kDa subunit" evidence="10">
        <location>
            <begin position="94"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="238"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="268" mass="31509" checksum="73AF0D20725DB1EC" modified="2013-05-29" version="1">MYLQRFKSSFSSLKCSNIYLRQGLLRFNFHTINSTLWISKEMGNKNEEKKTLGPNKETKERLYSYGGYIMSCLPKFVQQFSVWKDELVIYTSIKGLLPIMYFLRDHTSCQFKSVMDIAGVDYPERENRFEIVYNMLSVRYNARIRVKVYADETTHVPSIVELFQGANWYEREAYDMYGIFFVNHPDLRRILTDYGFEGHPLRKDFPLTGYTEIRYDEDKKRIVVEPLEMTQAYRDFSGGTSAWDQVGDGVDDRPDKFKVSTSKSENSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLG3</accession>
    <name>M7NLG3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02091</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874071.1">
        <property type="nucleotide sequence ID" value="XM_007875880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLG3"/>
    <dbReference type="GeneID" id="19895785"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02091"/>
    <dbReference type="eggNOG" id="ENOG502QUCF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_509123_0_0_1"/>
    <dbReference type="OMA" id="PEVNTWV"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06251">
        <property type="entry name" value="M14_ASTE_ASPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14447">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055438">
        <property type="entry name" value="AstE_AspA_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053138">
        <property type="entry name" value="N-alpha-Ac-DABA_deacetylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37326">
        <property type="entry name" value="BLL3975 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37326:SF1">
        <property type="entry name" value="BLL3975 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24827">
        <property type="entry name" value="AstE_AspA_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SPX" evidence="5">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="535" mass="60207" checksum="E9A4D905E27A991D" modified="2013-05-29" version="1">MNYSHEILKNIDNEFYKRLTHELEKIDNRYCYIEKNSADLLERLDESWNDEMPVIELNEWRKSLLQVITTLEELQEYIQINMVAIVKIKKKYDKNFKFLSNNLPAKASLNLLKTVGGSNELNINYSPMASKIDKYITPNLHFGTCKHDIGFDNKEILSLTSKFKFSMVDMNEYLLNKARELWRKHTPPPEVPEGCPNIKLLTLDDSEIPTTTSLDLESLPRGRISKLWISLIEDALKPLSVPVLVARGVKHGPVVGLTCALHGNEVNGIRVVHRLYQSELNPESLHGTIVAVIVANIQGFLSSSRGFESQDLNRLMPGRKNGSTSQQYAYNLIERIVKKFDYLIDLHTASKGRVNSLYVRANMLDDRTRKMAVLQNPQIIVHNTGPDGSLRSAAMAVSIPSITVEIGNPSIFQKRFVKNALLGVSNIISHLAMIPDEHQQAEFKPVICDKSYWIFTTKGGILSVIPEVNTWVRKGEVIATIHSIFGQLIETYTAPEDCIIVGKEIDPVASSGSRIAHIGVCRGFYGTGKVDDGHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLT1</accession>
    <name>M7NLT1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_03589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875683.1">
        <property type="nucleotide sequence ID" value="XM_007877492.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NLT1"/>
    <dbReference type="GeneID" id="19897276"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03589"/>
    <dbReference type="eggNOG" id="ENOG502QRVV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_258421_0_0_1"/>
    <dbReference type="OrthoDB" id="6288785at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22673">
        <property type="entry name" value="FHA_Ki67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="29"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1293"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1329"/>
            <end position="1340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1340" mass="152278" checksum="97699D4502DAAB77" modified="2013-05-29" version="1">MACLFGTLYVLRKGTEEEYAHFPITKRLNTFGRHLSCDVRLYDEVISRQHARLEIDDNGNAFLENLSVNGTFVNNNELDISENKKFRLNTGDIISLSGHKFRWEYPTNEKKDNQVVIHTPELKTYTPIKSIKQSSFLFANDKDVFDTYLMNEKPLQPILKENLVNEHVSIKIKTPKNNIVKSKILDVVDSGLRSKESPLGDVKNLKILASSIENSPEKQIISNDIFVLGPKDFTSKDKYDTSLPFSEKNIEIIKKENFNHNDSIKNKVFSPAKNSILDQDFQMPDLSPASNIKINVSPAIDKSMDDLILNRYFESKGSDVSLDSLLVEKKNMFSEKENDAIDLNSSLKIKRTESEQDDGILLHPVISLSKILPEKKISTSGICNNFYNSRGFKLEEDVIVSPPKEKSFSIFPDAQPSPLKFGSPVLHLVKKYYVDTRDLPRQLRDIKTKRHVYKKRPSFPPFIASKVLNNPALTNLRSRHSISDPSLPLSAYINKVEFVSEKQEKINLPTTPLEFLEILDDSEKKLLGWVPLCSSDNNFKENNLELLEASKYGISLKNNVICGASLLNSGKKKRHHENNLCSNNKLEIIYPEFKTFSPGKWVATYNGKKQKLYQSPVSSVTKNILKNNLSIANVSCLNPCSSANSLKDIDKMCSPGKWVLTAPGKKMKLYCSPDISTKSSNKLIYDFKLKSSTNSSQENDFFLKDGLVRFNSGVNGFYDSCIDYTDKNESFCVTDISFDSAIEKKVRFNDFTSLNSQEDSSCLENLHVDASESTKNNTGFLENIIDNTSYKSSLVNNTDNMQEFSINNKEDMNDSKISFMDQFMMNFNTEVMDGELFNFAKLSSSTIGLESLTGNIQESISNEFSFKSNDNFSELSKCPVFKEEHMEINQSIQKDIPEFQSIDDEKSTRNYDNQDVFMTEHFFRNHKKFNIMNKNICSIKSNDIGNNNFTDIHVCNQQPETADFMKLLNNSLDLRNRYIDVKEDKDVSYKNTHLIKDDICSLTYEEYKDLGDTKKVTNFFEDFETKKILNHSFSDKVSSKLDTDFLSIEKNNTSFETIEVLELDSNISQADKCFQSTDTNSSFVKIKCDTTYEGISVELLQEQCVGGSSSSPIKGSAGSIVPGKSKQGFIIEKSSKKTRELKPIRVSSRIREKAIKAINDKSKSESCEAVIFHENLCHNKYRITRNSRKAGDGNNNNIIGSAGQMKPSEEASGKKLIDNSIIPISKEIKLSSLKECTRMTRSRFLNEKLEQSKAQSNFKDLTNIKNLQHQVIDSRKDDIIADKIITKTLTKHNKENPKKRSVSQTISNIEKPSKRRSVLPMNDKNVKSSIKRVSLRNRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLV4</accession>
    <name>M7NLV4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875652.1">
        <property type="nucleotide sequence ID" value="XM_007877461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLV4"/>
    <dbReference type="STRING" id="1069680.M7NLV4"/>
    <dbReference type="GeneID" id="19897246"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03559"/>
    <dbReference type="eggNOG" id="KOG1861">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015513_0_0_1"/>
    <dbReference type="OMA" id="WPPQLKE"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF4">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="1">
        <location>
            <begin position="261"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="443" mass="52090" checksum="857F7E6C02B61E17" modified="2013-05-29" version="1">MLNGTQRYAAVNIKKPSNKLKPGNVFVSTEEASSSQVPARKKTQWPDSLKEFVGRCFENCSDKDRPSIEKELKEIITKAFEDDTVFSIDWDKIELKTLKKQRKYSKENLQSNRMNKVKTELSDLNTFRISEDEHQKNKRIKRFEKTNTVKSSDEILNVDTSFNRLDVIDWDEHTIVGRSQQLEKKYLRLTSAPDPETVRPLSVLKKTLEFLKAKWKEENNYIYICDQFKSLRQDLTVQRIKNDFTVMVYEIHARIALEKGDLGEYNQCQTQLFSLYNYNLPGHPDEFLAYRIFYLLHTRNKSDIHEVLLKLTEEEKKNKAIKHALDVRAALVMSNYHSLFKLYLDAPNMGGYLMDCFVERERVIASCRMFKAYRPSLSLKFLCQELSFESESECFEFLMARSSKDIFIQDEKSKSLHINTKDAFEYFEQARLKDKVIDIKGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NM38</accession>
    <name>M7NM38_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein MON2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_03419</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MON2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875505.1">
        <property type="nucleotide sequence ID" value="XM_007877314.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NM38"/>
    <dbReference type="GeneID" id="19897106"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03419"/>
    <dbReference type="eggNOG" id="KOG1848">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001169_1_0_1"/>
    <dbReference type="OMA" id="AWRLCLN"/>
    <dbReference type="OrthoDB" id="294853at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032817">
        <property type="entry name" value="Mon2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF333">
        <property type="entry name" value="PROTEIN MON2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16206">
        <property type="entry name" value="Mon2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HUS" evidence="4">
        <location>
            <begin position="189"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="5">
        <location>
            <begin position="961"/>
            <end position="1188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1682" mass="193062" checksum="6618447AED479488" modified="2013-05-29" version="1">MRWIASLTSELTHLVSETKRKHPELKAAAEQSLNEIKNFTDEATTVKRIRQNPAFLIPFLLGCNTQSAKCCAIAIGSLQKLIAVSAIPNLSLPSVLEAFREATLLGVEIQLKILQVLPMFLTNYTEDLSGNLLAEAFNICFILQNNKSTVVQNTASATLRQLVILVFDRTVCEVDVKHSKKESEINQALLDAHHLMEDLCLLINEDRPRMLNVQNLSKTFGLELIESILTNHPKVFQKHDKQIKLLRNLMFLVLRPFSNKSDFPVTVRSARIIYLLLRQHLKNLIVEGEIAFNLFCHILIDQDDNNWRRILVMEIFRGICTDNALISAIYEYYDADVSRKNILYEMIFSFNKLAGENPGLIGLGANILFSNQLSSSDSYDNMYEILGDAIDMFGTISGTIIDQCPPGLDSKASSVRISCIDQLDKSEVPILPPTYIYYLVFTCLNSVVDGIAKIIIPFFKRNLSRKLGDFKEKSQSISNILSESCLGNQEIFTCSKIIENMWPAFLAAFSTFLSASMSIDLFHNLVRSYRHFVQVSGYLGYNISRNAFLTTISKFSLPPVFIIPFNVLHSNLTGDSQNIPQLDTNNCTSGTTNATNFPLLHDSDNTMILTQKNLICLQAILLLSIHLGNNLGNSWAIVLETLRKVELIIHEMAKKNPVKFPHNILGVDIIYDTIQKEVCALPKKNNFIVDISSILLLINTVFENTKTFSDNSLLEMLKTICELNRFSEIFENKLPSEIKGLDIKKSVSTTNFYNYQGGAIFHKSDELAFTFHKINLICKINIERLFFGTSEENGWDIVISYLYSFIHSRKVDNLIRKQATKIFLDITKTVIISHSWKNLENSDKALRKILSIINFLSMKNIMGDINVQLYPNDRTIELEIISMALDTLNLLLNSLGHLISESWDIVFEIINSIFENELPSFASFKQDHSDILLFRKKELRSSLKIPKIVKDAFFSLQLICTDFLSELSSKHFLTLINILTKFCLQKDDLNISLAAIGLFWNISDNLRLKKSFQKSIQTFDSSNELNFLCPLEDDISVQDLLWIVLLFRLIEVILDDRFEVRNGAIQTIFRNFEIHGENIKSNLWKCCFRVIIYRIFFLFKKDILKNINNNECYEFLNNTNNRSFEDSLVLVISGLVILFSRNLNSLLSLEIFLEIWEKLLDFFTHSIELNSNDVFMNCCKAIDNILDRMEYDKLGSNYDDLYKKVWSVWEIFSNTVSITPNNLFKNQKLSQESLDTFVKFSRSLYKFIVSKNEISVINKLITSIFDALIYTRSPVYYLDVDYMTPLQSSILEVIDLLKDHNEQTCVLSLKLLAKISTLAFKDLSESTATIQNLSKIDKIFPTYIAISKTSFERMEEYFSKYSENTLIYKENAFFEMIKALSVPIKLKHKCPLTSRIGNGELFWKFATLKMLSILEKCDSEMIIPDSNIELWEAITDCLHGTLLFDYSGNNSIFFKESDEDFDISTYTKLTAVIFPLITNNIEISRNIAEIISKSSFVYNCPEQSLIFDHLSSITKIPNLEIKNYKFQKIVPYREKLGFICLNDLFELCSLKSKNQFSNKKCLAMITGTYLLKRCAMVLQQFILNQSMRGCIPISRIEHTEIIFILNNLVNREFYSDLFDFPDISDDNIDKFYCSDSLIVQLFPLFCAVLPHCYQDVELLKLISLYFQKVGNFIHIYEASVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMF4</accession>
    <name>M7NMF4_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_03234</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875300.1">
        <property type="nucleotide sequence ID" value="XM_007877109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMF4"/>
    <dbReference type="STRING" id="1069680.M7NMF4"/>
    <dbReference type="GeneID" id="19896921"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03234"/>
    <dbReference type="eggNOG" id="ENOG502S81D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088319_0_0_1"/>
    <dbReference type="OMA" id="TMMNLRE"/>
    <dbReference type="OrthoDB" id="1913277at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039205">
        <property type="entry name" value="NDUFA11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21382:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21382">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="170" mass="18427" checksum="770DD04624B70968" modified="2013-05-29" version="1">MASIFQERSYSEKDAVFSGLKSMMISGSVGLMVSAAENAITKNSSDIRSVLVRSRSIIMTYAVMGGLFSFTEAFVSNLRRKDDPFNAFLGGVVSGSVGAIRVRSLPAVVGYGMGLGCFMGLFDWCGGTLTGLYHDFYGENSKKLKETLFKVQYRRPRSEIVDAIGSGRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMG7</accession>
    <name>M7NMG7_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_03248</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875315.1">
        <property type="nucleotide sequence ID" value="XM_007877124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMG7"/>
    <dbReference type="STRING" id="1069680.M7NMG7"/>
    <dbReference type="GeneID" id="19896935"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03248"/>
    <dbReference type="eggNOG" id="KOG0900">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122625_0_0_1"/>
    <dbReference type="OrthoDB" id="10248551at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000002">
        <property type="entry name" value="40S ribosomal protein S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_uS10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_uS10_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="4">
        <location>
            <begin position="18"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="123" mass="14055" checksum="5A3AAA8FA9FE8AD2" modified="2013-05-29" version="1">MSYPSKGEEIEKRLHRIRITLTSRNVKNLEKVCSDLTQRAKDKNLRVKGPVRLPTCVLKITTRKTPCGEGSKTWDRFEMRIHKRIIDLHSPTETVKQITSITMEPGVEVEVTIQQSSQLSLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMI1</accession>
    <name>M7NMI1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Mevalonate kinase</fullName>
            <shortName evidence="14">MK</shortName>
            <ecNumber evidence="3 14">2.7.1.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PNEG_02058</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Mevalonate kinase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway. The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17065"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.36"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:17066"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="13 14">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="3 14"/>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874039.1">
        <property type="nucleotide sequence ID" value="XM_007875848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMI1"/>
    <dbReference type="STRING" id="1069680.M7NMI1"/>
    <dbReference type="GeneID" id="19895752"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02058"/>
    <dbReference type="eggNOG" id="KOG1511">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017814_0_1_1"/>
    <dbReference type="OMA" id="LMDFNHG"/>
    <dbReference type="OrthoDB" id="1652964at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290:SF2">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="14" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="14" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="15">
        <location>
            <begin position="120"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="16">
        <location>
            <begin position="292"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMR09878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="416" mass="47184" checksum="49E3B6DFA936F48D" modified="2013-05-29" version="1">MKTVFVSSPGKVILFGEHAVVYGKAAIAASVSLKSYLMIFSDESEESIVRIEFPDIDLKKSWKQDNFPWKDFSLNDPLLPPPRIDEVHISFLTYFSKDEPLLYSKIIQAFLYLYLSLSRYDKKKSVAFILRSAIPIGSGLGSSASISVCLAAGLLLFNDHITPPNGTLLDKRSLSIINSWAFNGEMCIHGNPSGIDNTVSSEGGIVFFRKTNSDPPFIFEIFHDFPALPLLLVNTLQLRSTSTLVNSVKNLYQNYKDIISPIFDSIDHISMNFKILYEKSRKSEHCYLDRLQVGTLMRINHDLLCALGVGHQKFDEIIKIANDYNIGWTKLTGAGGGGCVIILLREELNAEIIHEFELQLVSNGFEVYKVSLGDKGLGMLNNCDDDFYKKFINIRNKEQFEDFLEFEKTKYWKYWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMI6</accession>
    <name>M7NMI6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_03265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875335.1">
        <property type="nucleotide sequence ID" value="XM_007877144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMI6"/>
    <dbReference type="STRING" id="1069680.M7NMI6"/>
    <dbReference type="GeneID" id="19896952"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03265"/>
    <dbReference type="eggNOG" id="KOG2885">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018300_0_0_1"/>
    <dbReference type="OMA" id="QKKRTDN"/>
    <dbReference type="OrthoDB" id="444809at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029190">
        <property type="entry name" value="Rrp14/SURF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029188">
        <property type="entry name" value="Rrp14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007019">
        <property type="entry name" value="SURF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369:SF0">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15459">
        <property type="entry name" value="RRP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04935">
        <property type="entry name" value="SURF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA-processing protein 14 N-terminal" evidence="6">
        <location>
            <begin position="8"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal" evidence="5">
        <location>
            <begin position="203"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="191"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="47756" checksum="AD33A7DBD73D2047" modified="2013-05-29" version="1">MFNSREERIKSNNKEFEAFISLIPQKYYYNETLKNSLKGRKKTKEESRYLKKLKLDPDSYKNIDNMNKELNNEKKQPLNMINCIGNEKGEFSNILEEKKSKKKEKKVNENKVLEVNSKVSKKDENEVNKKGLEDKVETVIMENGKNENKKEETCKKEISEKSKEKSPDIFDLRLKLASRIEQLRANRKISKNGIDSSAKNRDSILETRKKKKNHDQKMISTKIKQKKALDDANEHRNFSGESLENNNISNKSEETDLMYGKITFESDIEDKHELSRKKHNSMDLVGAIRHLEAKKQRLSRLSDEKKKEIMVSDAWKEAFLRSQGEKVKDNEALLKKSLKWQKRKKRKSAKAWNERHMQLLKTKQLRQKKREENIELHRTLQKKKQSGKMQRRPGFEGSLCIKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMM4</accession>
    <name>M7NMM4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CDC20/Fizzy WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_03304</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875380.1">
        <property type="nucleotide sequence ID" value="XM_007877189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMM4"/>
    <dbReference type="STRING" id="1069680.M7NMM4"/>
    <dbReference type="GeneID" id="19896991"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03304"/>
    <dbReference type="eggNOG" id="KOG0305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014831_4_1_1"/>
    <dbReference type="OMA" id="WSKNTDE"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000025">
        <property type="entry name" value="FIZZY-related 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF1">
        <property type="entry name" value="FIZZY-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="10">
        <location>
            <begin position="206"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="334"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="376"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="464"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="117"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR08477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="518" mass="57832" checksum="970CB5F91D794CAF" modified="2013-05-29" version="1">MFEVEFDKRLRSASQGNRLNEDGQEGLRGSPSRRRIKVGYGDRFIPSRDGIDLQASFNLADNSSEISKAKRKTGNEVDAQRLEESNKIFLHLLRFELFGSTILNSFSNLPSSDLFVGSRTPPPQKTPINRPVTPSTPPRNLFSYISPQNRTPTSGTRTSGSGGRNCIDDPTREIYSLSPVRFDSQRLLLSPRKQPRAIPKVPFKVLDAPELHDDFYLNLVDWGCNNILGVGLGTCVYLWSAHSGKVTKLCDLGPNDSVTSVCWIQRGSHVALGTNKGLVHIWDAEQCKRTRTMLGHTSRVGSLAWNEHILTSGGRDHQIFHRDVRVPEHHIKQLSAHKQEVCGLKWNCEDGQLASGGNDNKLIVWDRLNETPLYKFSEHTAAVKAIAWNPHQHGILASGGGTADRTIKFWNTLNGQQISEIDTGSQVCNLAWSKNSNEIVSTHGYSENQVIVWKYPSMSQVAALTGHTYRVLYLAMSPDGQTIVTGAGDETLRFWNVFSKNKNDSDRDSLLDPFTKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMR6</accession>
    <name>M7NMR6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875054.1">
        <property type="nucleotide sequence ID" value="XM_007876863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMR6"/>
    <dbReference type="STRING" id="1069680.M7NMR6"/>
    <dbReference type="GeneID" id="19896691"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03004"/>
    <dbReference type="eggNOG" id="ENOG502QRPI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_687205_0_0_1"/>
    <dbReference type="OrthoDB" id="992776at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100">
        <property type="entry name" value="IMP2'P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100:SF4">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="1">
        <location>
            <begin position="261"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="439" mass="50264" checksum="6F5BB6DE4A872611" modified="2013-05-29" version="1">MVFDAAKPIKKNKSFSSMELVLDEERKEILKFLETREMRLSTGLKNKCFLENNLEVGFRSDINLSNTLNVSSLPEGSRFLNESNSIFTKSSSIENVMQKSLDDVFLEKFDRNDVIESNSHDGECFDNYIRSASPYLNSTVNELESLSLSNGFEIQGKKNPVNPLKDSYHSSMLPSRVSKIITNKIHTSKNASKSKDSNIFSQTNMNFSLEQEIDADEDRRSQNMKIDMGTIIFTEDRTIRTIKRGEYPSSFSESRRIRSYLVSIDLSSESLYALEWAIGTIVRDYDIMMIVEAIDKDDKDDKGILELEKERLAAMEEICQITQKLLKKTKLILQIEIEIIHHKTPKHLLTEMIDYLEPTLVILGSRGCSSLKGFFFFFCICINCYLRVILGSFSNYIVNKSSVPVMVARKKPRKSKSKYAVFGTNIRMANNLFTKTIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMW5</accession>
    <name>M7NMW5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit delta, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">F-ATPase delta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PNEG_03299</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875374.1">
        <property type="nucleotide sequence ID" value="XM_007877183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMW5"/>
    <dbReference type="STRING" id="1069680.M7NMW5"/>
    <dbReference type="GeneID" id="19896986"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03299"/>
    <dbReference type="eggNOG" id="KOG1758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084338_0_0_1"/>
    <dbReference type="OMA" id="HQTLYSE"/>
    <dbReference type="OrthoDB" id="270171at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048938">
        <property type="entry name" value="ATPD_C_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21334">
        <property type="entry name" value="ATPD_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="14">
        <location>
            <begin position="34"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="F1F0-ATP synthase subunit delta C-terminal" evidence="15">
        <location>
            <begin position="121"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMR08471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="164" mass="18114" checksum="912DA7F237D174C1" modified="2013-05-29" version="1">MNLIQTSAKHLSCRNKIYGFFCRRYAKEALTDKLRLTFLLPHSILYKAQDVFQVNIPATSGSMGILALHVPTIEQLHPGVVEVIEENGVSNKFFVSGGFATMQPGSDLFINAIEAYPLDDFSLEAVNENLQKAQKVASGNGSEEEIAEAKIQIEVLENLQTSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMY3</accession>
    <name>M7NMY3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_01797</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873765.1">
        <property type="nucleotide sequence ID" value="XM_007875574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMY3"/>
    <dbReference type="STRING" id="1069680.M7NMY3"/>
    <dbReference type="GeneID" id="19895491"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01797"/>
    <dbReference type="eggNOG" id="KOG1315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034009_0_0_1"/>
    <dbReference type="OMA" id="PGTWIFV"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="122"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR10043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="375" mass="43069" checksum="238587DF4F9B5878" modified="2013-05-29" version="1">MQMVCDPSSIKVNRAFGWVIPPLLVGVMGFTTWVYIVLICINHLVNRGRSLGIALLVVFSILLSMVAFSFARIIFTSPGYVPRFKDLKICSSNDIELRNHITDQMRTFCLYDAYVCENDGFPRWCAICEVYKPDRAHHCSEVQRCVLKLDHYCPWVGGVIGFTRYKFFVLFIFYVTLICVFVICSCAPLIREYYMMNGHVPGPWIGILAMASFFTLFLGPFTSIHVFYIFRNSTTIESINFYARFYLLNVLYDTDKSGFKRANITTNPGDHPWDLGWKENWCSVMGKKWWEWFFPIKGSPGNGYHFNYNPDKLDEWKIIAKQVGIVPTYLNSSKSMTSNLQSEYSSTLSQPGFWTDSGAPTSSVNSVKMLNEQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP92</accession>
    <name>M7NP92_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01237</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873157.1">
        <property type="nucleotide sequence ID" value="XM_007874966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP92"/>
    <dbReference type="STRING" id="1069680.M7NP92"/>
    <dbReference type="GeneID" id="19894934"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01237"/>
    <dbReference type="eggNOG" id="KOG0581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="OMA" id="VGTMYFM"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050850">
        <property type="term" value="P:positive regulation of calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000263">
        <property type="entry name" value="MAP kinase skh1/pek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF5">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINAE MKK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="111"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="399" mass="45198" checksum="B7A068F9D2583684" modified="2013-05-29" version="1">MQPEAYQTNLQCSEEIKNKLRIDESKSSSETSLINQIPILTLSIPSKRSTSHIFDATRITDNSDISHNEDHDFKGISETNRSPDAFSYNGSYFTKILLDEVWQHSAHSDEIIELEKLGEGISGSVSKCILKHTGTLFALKTILVDTSPKIQQQILRELSINRTCSSEYIVQYYGAFVDEVSSNISMAMEYCAGGSLDRLYKKARANGARIGEYPILKIAENTLKGLNYLHTRKIIHRDIKPSNILMTLEGQAKLCDFGVSGELVSSMAKTFTGTSYYMAPERIKGETYSITSDIWSLGLTLMEISQNRFPFPPEGEPPLVPIELLNYIVNISNLELVDEPNNKIKWSDDFKHFLKTCLERDGAKRPNSQQMLEHPWIIKHSIIKIDMAKWIKQILELPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPE2</accession>
    <name>M7NPE2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein LST8 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat LST8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874479.1">
        <property type="nucleotide sequence ID" value="XM_007876288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPE2"/>
    <dbReference type="STRING" id="1069680.M7NPE2"/>
    <dbReference type="GeneID" id="19896163"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02470"/>
    <dbReference type="eggNOG" id="KOG0315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_5_1"/>
    <dbReference type="OMA" id="VQRNYKH"/>
    <dbReference type="OrthoDB" id="400at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032535">
        <property type="term" value="P:regulation of cellular component size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000505">
        <property type="entry name" value="Blast:Protein LST8 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF0">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="74"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="115"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="205"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="249"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00074814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="309" mass="34309" checksum="ED624E12DD2F0F0D" modified="2013-05-29" version="1">MHAHSIILVTSGYDKTIRFWEALSGICLKTIQHADSQVNRLCISPDKRLLAAAGNRHIRLYDIQTIAPNPILTLDGHATNVTGVAFHGEGKWVVTSGEDGSVKLWDPRTTSVQRHFKHGAAVNDVVVHPNQGDLISCDQTGCVKLWDLKENLCTGMWANEDEIAIHTISVASDGSMLVAGNNEGTCFVWHTESNDLQLQEPDHKFQAHKRYITRCLLSPDANHLATCSADATIKLWSTEKLEFSIERQLVGHQRWVWDCAFSADSAYLVSASSDHVARLWELSSGETIRQYNGHHKAAVCVALNDRHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPT1</accession>
    <name>M7NPT1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02459</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874468.1">
        <property type="nucleotide sequence ID" value="XM_007876277.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPT1"/>
    <dbReference type="STRING" id="1069680.M7NPT1"/>
    <dbReference type="GeneID" id="19896152"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02459"/>
    <dbReference type="eggNOG" id="KOG2020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011906_0_0_1"/>
    <dbReference type="OMA" id="WAFKHNN"/>
    <dbReference type="OrthoDB" id="27218at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000022">
        <property type="entry name" value="protein EXPORTIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="34"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1057"/>
            <end position="1083"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1083" mass="123996" checksum="049EB5F7CADE8234" modified="2013-05-29" version="1">MDDILNFEQDFNVELLDRIVHTFYQGSGVEQQQAQRILTQFQEHPDAWMRVDTILEKSNVVQTKHIALSILDKLISTRWKILPREHCQGIRNFVVAIMIKTSSDETTLHKEKQYLNKLNLTLVQILKQEWPKNWPTFITEIVNASKTNLSLCENNMAVLKLLSEEIFDYSAEQMTQVKTKNLRNQMSGEFSEVFQLCSEILEKAQKTSLILATLETVLRFLNWIPLGFIFETNIIHTLCTRFLEVSEFRNVTLKCLTEIAGLSVMPQYDEKFVSLLNLTMSSINNIIPLNTDFRVAYDSSNSQEQDFIQNLALFLSTFLGTHVKLVENQENRDLLLNAHFYLIKISQVDEREIFKICLEYWSKLVAELYEEIQQLPITDMNPLLSLNLSASLASGGATPASMYANIPLRKHIYSEVLSNLRVVMVEKMVKPEEVLIVENDEGEIVREFVKESDTIVLYKSMRECLVYLTHLDVVDTEIIMSDKLARQIDGSEWSWANLNTLCWAIGSISGAMNEETEKRFLVMVIKDLLGLTEMKRGKDNKAVVASNIMYIVGQYPRFLKAHWKFLKTVVNKLFEFMHETHEGVQDMACDTFIKIAQKCRRHFVAQQAGEHEPFIDEIVRNLHKITEDLSPQQVHTFYEACGYMISAQPSKTIQERLISELMKLPNAVWDNIIQQAGQNVDVLDNNETIKIIGNVLKTNVSACSSIGGHFYRQIGNIYMDLLGLYRAVSTIISNTVASQGNIATRTPRIRSLRTVKKEILKLVEVFVSKADDLEAINNALIPPLLEAVLGDYNRNVPDARDSEVLNMMTTIISRLGSLMTEAIPIVLQSVFECTLAMINKEFTEFPEHRVGFFKLLHVINLNCFPALLRLPAPQFKLIIDSIMWAIKHTTRDIAEIGLNICLELINNIANTETSVANFFFQQYFLSILQDIFFVLTDTDHKSGFKLQSVILARMFHLVESGAIQASLYTSQQVRDENTPNSVFLKEYVVSLLHSAFPHLQLGQVQSFVLGLFSLNMDIPKFKLNLRDFLIQLKEFSGDDNAELFQEDRDMELEAKQKADRERALNVPGMIKPSELPTIDEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPT4</accession>
    <name>M7NPT4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00868</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872778.1">
        <property type="nucleotide sequence ID" value="XM_007874587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPT4"/>
    <dbReference type="STRING" id="1069680.M7NPT4"/>
    <dbReference type="GeneID" id="19894566"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00868"/>
    <dbReference type="eggNOG" id="KOG3250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054426_2_1_1"/>
    <dbReference type="OMA" id="GTYKQFR"/>
    <dbReference type="OrthoDB" id="10265275at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF5">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="256" mass="30386" checksum="0393921DA9CA7CD7" modified="2013-05-29" version="1">MKQSSISLEYFLKKAYLLEGKEVVKVIEEVLEASNIFFFSELLKIPSIQKLKGTENEPYLDILYIFCYGSYKDYQERKLFLPYLSENQVYKLKKLSLISLSKNFKNLMYSDLLLYFDLSDYKELEKLLIDCIYSSLLSGKFDSKNKCFCVEYTCGRDISFSNIDELINKLSLWSENCTDVLNKLEYRVKIIKDEIFSKKSLEDYQKFIHQKMENIETQEKGTYKGKGVDTTHYNPMEMDEMHIDDNISLWKNIFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPU1</accession>
    <name>M7NPU1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">R3H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02591</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874606.1">
        <property type="nucleotide sequence ID" value="XM_007876415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPU1"/>
    <dbReference type="STRING" id="1069680.M7NPU1"/>
    <dbReference type="GeneID" id="19896283"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02591"/>
    <dbReference type="eggNOG" id="KOG0108">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_465479_0_0_1"/>
    <dbReference type="OrthoDB" id="434258at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12253">
        <property type="entry name" value="RRM_PIN4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034186">
        <property type="entry name" value="PIN4-like_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF17">
        <property type="entry name" value="RNA-BINDING PROTEIN PIN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="256"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="R3H" evidence="5">
        <location>
            <begin position="379"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="199"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="342"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="586" mass="66772" checksum="0B7923E2FEE95CF1" modified="2013-05-29" version="1">MAVTDESSQLEAYDEAEHHKKMNYYQGVKNFSTKRDDISQSRLFNGYSLNHEKDIKELPLLRSFSSPLLWTNNLGKTQASATESLTQASTPMSIQSPDNIFSRRFPFQYTQTSSQQTALHNDAAHFERLKDSHYAFCPQTAPFISVNTMGSSNFQSSTISPSYPYYYSTTQSIPYDNYGYASWRSIPEGKERVTNKWVNNSDTNNSSQNPNVSTTFMPSGTSKANTSDNLQENSFQESTITNLKNTARTEDGVLPSAIVVKNIPFQIKKEQLLELFDTLDIPKPYAFNYHFDNGNFRGLAFANFYTPEETTRVILSLNGHDIMGRKLRVEYKRILPIADREKANREKKEKRNQYEEQHNSSNPGFFKGKRKSKDIDLNDEATLKIYSRLLLFRNDQSPNAPNELIFPLDTSLQQRRIIHYIAEKLGLEYTSCGENDAKYIVINRLNSNNTDNIPMNFWNKPNFGISDQSVSPVASLSATNLTSNGLPLTSNFSEKSDMNSRIRSMKPLNDIRTMNTQILSKTNFHQVQPLNAVTNTSFDLGVSNLQNDINVMMQNLNFNVTNKQSKNGEWGSKKGFKNMIMKTNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPY1</accession>
    <name>M7NPY1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vps72/YL1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02511</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874521.1">
        <property type="nucleotide sequence ID" value="XM_007876330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPY1"/>
    <dbReference type="STRING" id="1069680.M7NPY1"/>
    <dbReference type="GeneID" id="19896203"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02511"/>
    <dbReference type="eggNOG" id="KOG4137">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071116_2_1_1"/>
    <dbReference type="OMA" id="VIKPMAP"/>
    <dbReference type="OrthoDB" id="49520at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029525">
        <property type="entry name" value="INO80C/Ies6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200:SF1">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="5">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="125" mass="14258" checksum="F42429F5F8A80A83" modified="2013-05-29" version="1">MVSSSHSLLDTVDIGVLEKPFKNPHFKRNPRRNKTLRQVLMYEAQLHTSTSPLSPDVPTYSNIEASPSLFPCSKWCDITGLQGLYTDPKTGLRFHNKEVFSIIKNMTQGVEQQFLQLRGSHVMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPY6</accession>
    <name>M7NPY6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GTPase-activating protein GYP7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">GAP for YPT7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02516</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874526.1">
        <property type="nucleotide sequence ID" value="XM_007876335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPY6"/>
    <dbReference type="STRING" id="1069680.M7NPY6"/>
    <dbReference type="GeneID" id="19896208"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02516"/>
    <dbReference type="eggNOG" id="KOG2197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004457_0_1_1"/>
    <dbReference type="OMA" id="WWREQRG"/>
    <dbReference type="OrthoDB" id="10264062at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000005">
        <property type="entry name" value="TBC1 domain family member 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF502">
        <property type="entry name" value="SMALL G PROTEIN SIGNALING MODULATOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="402"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00072091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00082648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="727" mass="87081" checksum="89332FB2437DC86F" modified="2013-05-29" version="1">MCLDIPTNMKNNISQLFNSYEQTKLIFSKSKVHIYKEPFSRKNDFGYVILVEKISKHQLTKPINIENIFLFWIPESFIISSDDYETYRSVEENNYNNNDENEYIISLPLNSHEDIHFISLLKIHSLLIKPPINESIGSITINTHEKSNYLTLFFNDNEYINKNLYNKISLEENIKPFDEEKKILWGGEYLLIRLKSIINIKHLSTEENVYIVNHDSIDTVNIQSIDNNNQEKIQDIKEDTKIETLKKAYKKARWNILERFSLITRFSHEKTKDILNTSFAKNMLLSNFPPQLQKFLNSEQTINIMEEYDAARLYLARWAARIAEDSEKDRHNKIIWSCKDTNTWNKKTLPNNFEMLELNTFENNMKITNDPILEKQWKSWFNNTGKLWKTEKSIKKNIFYKGIHSNIRKEVWCFLLKIYPWDSSEEERKIIFLEKSNRYMQLKQGWQNNKEKQADEVFKDQKHRIEKDVHRTDRKTKSSAETNYHLETMTNILLTYNEYNRDLGYVQGMCDLLSPLYIVIENEVLSFWAFVDFMKRMQYNFSENQSGMRKQLMILDQLIQLIDPKFYTHLENTSSTNFFFFFRMLLVWFKREFEWDDVLRLWEILWTDHITSQFHIFVALAILDKHKEIIIDHLKEFDEVLKYINDLSMTIDLESTLQRAITLFYKFKQIVETIDANFSKDVLSTDHSEKQEHNNAKNNSNYLQNQNEKSPLISNYLRELLNTDSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ52</accession>
    <name>M7NQ52_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_02566</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NUF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874580.1">
        <property type="nucleotide sequence ID" value="XM_007876389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ52"/>
    <dbReference type="STRING" id="1069680.M7NQ52"/>
    <dbReference type="GeneID" id="19896258"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02566"/>
    <dbReference type="eggNOG" id="KOG4438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025461_1_1_1"/>
    <dbReference type="OMA" id="YLKMEAH"/>
    <dbReference type="OrthoDB" id="8194677at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035974">
        <property type="term" value="C:meiotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140483">
        <property type="term" value="F:kinetochore adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140456">
        <property type="term" value="P:initial meiotic spindle pole body separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000073">
        <property type="term" value="P:initial mitotic spindle pole body separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051383">
        <property type="term" value="P:kinetochore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990571">
        <property type="term" value="P:meiotic centromere clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.60">
        <property type="entry name" value="Ncd80 complex, Nuf2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005549">
        <property type="entry name" value="Kinetochore_Nuf2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041112">
        <property type="entry name" value="Nuf2_DHR10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038275">
        <property type="entry name" value="Nuf2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650">
        <property type="entry name" value="MEMBRALIN/KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03800">
        <property type="entry name" value="Nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18595">
        <property type="entry name" value="Nuf2_DHR10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Nuf2 N-terminal" evidence="13">
        <location>
            <begin position="4"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Nuf2 DHR10-like" evidence="14">
        <location>
            <begin position="255"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="148"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="305"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR09231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="442" mass="51111" checksum="DE57248596811D10" modified="2013-05-29" version="1">MTSNYIFPTLKPPEILQCMTELGIPFSEEDLIKPTCQRMKLVYEAFSDILMGITWENYDNFVCACHNELEYSGIYTDSLSIIIFHQKLIKLMTEVGIDDFSIRDLIKPEAARVKKILSAVINFAKFREERMPVFETHAQKAESYVSRHQDLVFQNQDLSEKLKNLKIKQADEVLLVKKSKEINVALTNDLRELKKIQTALTNEIDVLKTEKAEIAERLTNNQFITVNTKQECMKLRSRIVHSPEKLKQLISDMGSSLASEKSSIASLEKKSRELQNKIDAIGVVEQDILNCIKLMEECEIEIAKVEEASRKVAKHQEMVDQKELEVREVEVKDQQLNRQLANAEDKLARIQRSAEAKREAAQKKMAEIRKEYNIITVERAERAHEMDRKRTIIESTEKKISELRSHIESEVLAIQNEFSKLKSHVELYMDEMNRCMEIAATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQA3</accession>
    <name>M7NQA3_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872952.1">
        <property type="nucleotide sequence ID" value="XM_007874761.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQA3"/>
    <dbReference type="GeneID" id="19894737"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01039"/>
    <dbReference type="HOGENOM" id="CLU_2498795_0_0_1"/>
    <dbReference type="OrthoDB" id="4227028at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011431">
        <property type="entry name" value="Trafficking_Pga2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07543">
        <property type="entry name" value="PGA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="86" mass="10339" checksum="4732AA7BC5A71161" modified="2013-05-29" version="1">MNWQIDYNLKDLLRIVTIVCGYLLIRVYLQKWIKSKQARDYETKDNDKSLEKATLHLNTVIENDLEEETLVWGAVRRKEQKMKLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQH7</accession>
    <name>M7NQH7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874295.1">
        <property type="nucleotide sequence ID" value="XM_007876104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQH7"/>
    <dbReference type="STRING" id="1069680.M7NQH7"/>
    <dbReference type="GeneID" id="19895993"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02300"/>
    <dbReference type="eggNOG" id="KOG0536">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046313_2_3_1"/>
    <dbReference type="OMA" id="CHLNDAW"/>
    <dbReference type="OrthoDB" id="432299at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000001">
        <property type="entry name" value="Cytochrome b5 reductase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051872">
        <property type="entry name" value="Cytochrome_b5/Flavoprotein_Rdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237:SF1">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="5">
        <location>
            <begin position="28"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="105" mass="12153" checksum="4CC1B32CA5885C2A" modified="2013-05-29" version="1">MFANIPNILDWEQLKRSSNFPRRITAPYLSITQAELKKHCHLNDAWIVLNGKVYDITPYIPFHPGGNEIMKGAGKDGTKLLMSIHPWVNYEYLLDACWIGLFTYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NR02</accession>
    <name>M7NR02_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation initiation factor RLI1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-binding cassette sub-family E member RLI1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02127</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the multifactor complex (MFC) involved in translation initiation. Required for the binding of MFC to the 40S ribosome. Required for the processing and nuclear export of the 60S and 40S ribosomal subunits.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874108.1">
        <property type="nucleotide sequence ID" value="XM_007875917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NR02"/>
    <dbReference type="STRING" id="1069680.M7NR02"/>
    <dbReference type="GeneID" id="19895820"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02127"/>
    <dbReference type="eggNOG" id="KOG0063">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017344_4_1_1"/>
    <dbReference type="OMA" id="MVCIQNG"/>
    <dbReference type="OrthoDB" id="6593433at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03236">
        <property type="entry name" value="ABC_RNaseL_inhibitor_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000144">
        <property type="entry name" value="ATP-binding cassette sub-family E member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000152">
        <property type="entry name" value="ATP-binding cassette, sub-family E, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034348">
        <property type="entry name" value="RLI_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009945">
        <property type="entry name" value="PRK13409.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="78"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="353"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00067238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00082546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="608" mass="68596" checksum="7352CAACC3C04D2E" modified="2013-05-29" version="1">MSKKTQTGSSEKLTRVAIVNSDKCKPRKCHQECKKSCPVVRGGKLCIEVTPESKISWISESLCIGCGICVKRCPFGAIHIINLPTNLESKVTHRFSENSFKLHRLPTPRPGQILGLVGANGIGKSTALKILAGKLKPNLGQHNNPPDWEEILRYFRGSELQNYFTKVLEDSLKAIVKPQYVDHIPRTIQGPAKTVNELLDFKLEKNNKDEIIDILSLRDLLRREVDQLSGGELQRFAIAIICIQKADIYMFDEPSSYLDVKQRLNAAKTIRWSLNPDNYIIVVEHDLSILDYLSDYICVLYGMPSVYGVVTLPFSVREGINIFLDGNIPTENLRFRSESLQFKISDSSDIFSLERNKAYVYPSMTKKLGDFTLEISAGEFTNSEIIVMLGENGTGKTTFIKLLAGILKPDGKEEVLGLSVSLKPQKITPKFQGTVRMLFLKKIKTSWLNSSFQSDVCKPLNIENIVDHEVQDLSGGELQRVAIVLCLGLSADVYLIDEPSAYLDSEQRIIVSKVIKRFILHSKKTAFVVEHDFIMATYLADRVIVYEGQPSVKVYTNPPQSLIDGMNSFLSNLDVTLRRDPNTFRPRINKQDSQMHQEQKNSKNFFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>M7NR50</accession>
    <name>M7NR50_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Antiviral helicase SKI2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_02175</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874158.1">
        <property type="nucleotide sequence ID" value="XM_007875967.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NR50"/>
    <dbReference type="STRING" id="1069680.M7NR50"/>
    <dbReference type="GeneID" id="19895868"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02175"/>
    <dbReference type="eggNOG" id="KOG0947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002902_1_4_1"/>
    <dbReference type="OMA" id="DHVNIIM"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990074">
        <property type="term" value="P:polyuridylation-dependent mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000354">
        <property type="entry name" value="ATP-dependent RNA helicase SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000987">
        <property type="entry name" value="DEAD/DEAH box RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000001">
        <property type="entry name" value="Ski2 ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040801">
        <property type="entry name" value="Ski2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17911">
        <property type="entry name" value="Ski2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="297"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="567"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="507"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="507"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR09591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1239" mass="143255" checksum="1FB015EFB53C484A" modified="2013-05-29" version="1">MQHSDLFEAFEAIKTSLGKKKDDVFYFGEVSRQNFESVFSRDEVFAQLEQFMVPPLEFSMEWLNELHGYVGKEVEYKELFQVVPFICQMSVEFIREGLEGRIVGYKEEAVSMEINSRNSTTFERNPAPRGDFIRGRSTFLPFVSERLKVLKLDEDKNNEKDMDLFLVAPGLSRTGILKKYEQPNKFRFELDENVDPNHWRFDSIDSFPLDNEEKLNDRISDHSKIDRSSDPVDNFLSSEFSLSFSNIGVSKYSTKQKIKEWAHVVNIKADFSNFHELVPNMAYNFPFELDSFQKFAIYHLERTESVFVSAHTSAGKTVVAEYAIALALKHMTKAIYTSPIKALSNQKFRDFYDTFEDVGILTGDIQIRPEASCLIMTTEILRSMLYKGSDLIRDVEFVIFDEVHYVNDFERGVVWEEVIIMLPEYVTLILLSATVPNTKEFAEWIGRTRQKDIYVISTARRPIPLEHFLWVNKKMFKIVDEKEKFLMQSYKDAAMVLKKDKNIVSTQLNKGGSHDSNSLRNQGRGNLNRTANSQNISKKGEKNTSIRGSDRAIFKDNEKQDRSIWIYLVNHLRKINLLPVVVFVFSKKKCQDNANSLANLDLLNHTAKSEVHVIIEKSIARLRAEDTKLPQIIRMRDLLSRGIGVHHGGLLPIVKEIVEILFTRSLVKILFATETFAMGINMPAKSVVFSGIRKHDGQEFRYLLSGEYTQMAGRAGRRGLDTIGTVIIMCNDDIPDINTLTRILLGNSTKLRSQFRLTYNMILNILRVKTLKVEEMIKRSFSENTSQALLPEHQKEIMLYEKNLSLLKHEPCSFCDIDLILFYNENTEYNQLTKICYQLALSSSYGKKIFSPGRVVIYKENNLYRSLAILLSEASVSFNGEKCFHVLYVKQKDSKNQVNKLPFIPVFWNYDFGLDSLKAEQFKEKILSVSSIELITQIVVKVDVSAVRSRIKESFYNICEQIKKARLVKDLEFLECSWVNVRDLKFKELFMKRKLCKSNMYNKKCLECPDFVLHFLKAHERNMLVEKIEVLEHLISDQNLELLPDYEQRIGVLKELDYIDDNLNVLLKGRVACEINSAHELVLTELIFENTLAEFESEEIVALLSVFVFEEKTESLPSISPHLEKGKEMIINVVKKINSVQDKYQVLSLCDTLDFENKSCFGLVEVVYEWARGMSFERIMDLTDVLEGSIVRVMTRLDQVLRECASAARIIGDISMYSKMEDCQEKIRRDIIFSPSLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NR93</accession>
    <name>M7NR93_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutaminase</fullName>
            <ecNumber evidence="2">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00274</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872145.1">
        <property type="nucleotide sequence ID" value="XM_007873954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NR93"/>
    <dbReference type="STRING" id="1069680.M7NR93"/>
    <dbReference type="GeneID" id="19893972"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00274"/>
    <dbReference type="eggNOG" id="KOG3210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069674_0_0_1"/>
    <dbReference type="OMA" id="GMIMLAD"/>
    <dbReference type="OrthoDB" id="2039at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903600">
        <property type="term" value="C:glutaminase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008614">
        <property type="term" value="P:pyridoxine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01749">
        <property type="entry name" value="GATase1_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000010">
        <property type="entry name" value="uncharacterized protein LOC100176842 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01615">
        <property type="entry name" value="PdxT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021196">
        <property type="entry name" value="PdxT/SNO_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03800">
        <property type="entry name" value="PLP_synth_Pdx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005639">
        <property type="entry name" value="Glut_amidoT_SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01236">
        <property type="entry name" value="PDXT_SNO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="55"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="146"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="218" mass="24131" checksum="0E0C0B13B530B095" modified="2013-05-29" version="1">MSVNENKNINVGVLALQGAFYEHYKLLKSFCFVNASLVRNVADLSSLHGLIIPGGESTTIGYLLSIDGLGEEIKARVKNKSLSIWGTCAGMILLAKKVEGMKKGGQYILGCLDIVIKRNYFGRQINSFSSILSSKVIKKEFLAVFIRAPVVLSIISPNVSVLATINKAGEDNKILESGAIVAVQQDNILATSFHPELSNDNQWHEWWLNNLKERYKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRB1</accession>
    <name>M7NRB1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01961</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873938.1">
        <property type="nucleotide sequence ID" value="XM_007875747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRB1"/>
    <dbReference type="STRING" id="1069680.M7NRB1"/>
    <dbReference type="GeneID" id="19895655"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01961"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_378604_0_0_1"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16461">
        <property type="entry name" value="RING-H2_EL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF69">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="659"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="22"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="543"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="703"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="543"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="713"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="732" mass="80642" checksum="3FE482E680269C03" modified="2013-05-29" version="1">MGQASSFQNRRQENILERTETANATHTGHHHNTTIADTLSSSVDNTEQNDTEGLSSNGNASRASRFRRHLTAFSRLGGLSPNRHHTSSSVSRIPYSIGNRRRSMFGSSIPRRNTVFELPQTHFSISSNQLTTTEYLDLHTLNRGDYTFTVRDLPLVDMSGIENYIPERPVSESSVNNDHQLFRGIIRRSQRNTLSRNTRRALEISGRIRTNNDAIMQHSFNGSGLNAISLRPGEDQAAVLSRLLSVAAAATAASLVGNNEQAIAEAQDIAMSQNPTNDRDSHVVDGSFEGFLRALQNGRLAAALRNGGSENGGGIPNENEENSSIQPLNFFRMFRFGNSQGSTQEGEDDPQNPRLVPIIIVGIRSVPPRDITSPGTQHTSPFFDTLANLSVNMPLNYETSYQRDTEEREANEQGVFSSNSPIHSISMSERPISSSMNIVDENLSNNEGIVNNLEPSRPSSISASIFQNLGSTDQISRYDTNIHSSMPSGESSIQHHNSFHIGSSFTQRHSNLNEHVSENANLNNNNTSELNINSIERVDNNNASRINSNINGTSRNDNSRSDRSSTTRSGSSNIDNRHNSTRSWIIYVLGGSYPEDHPILTTPSLFTDSPTYEDMLLLSSLIGPAKSPVATKDEIESAGGLHVLSVNSSSADIYLEERCVICLNNYEIGEECRQLNKCKHFFHKACIDEWLMTGRNTCPTCRAEGVNSRKNKSPTSNITSEQSSTNIPMTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRI0</accession>
    <name>M7NRI0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha</fullName>
            <ecNumber evidence="4">2.5.1.58</ecNumber>
            <ecNumber evidence="3">2.5.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">CAAX farnesyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FTase-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ras proteins prenyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Type I protein geranyl-geranyltransferase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_02057</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="4"/>
    <dbReference type="EC" id="2.5.1.59" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874038.1">
        <property type="nucleotide sequence ID" value="XM_007875847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRI0"/>
    <dbReference type="STRING" id="1069680.M7NRI0"/>
    <dbReference type="GeneID" id="19895751"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02057"/>
    <dbReference type="eggNOG" id="KOG0530">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026582_1_1_1"/>
    <dbReference type="OMA" id="HRHTIID"/>
    <dbReference type="OrthoDB" id="272289at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007323">
        <property type="term" value="P:peptide pheromone maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF1">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE_GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR09877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="316" mass="37979" checksum="78435C026F194BCF" modified="2013-05-29" version="1">MDASNSWKLELHEILDFDNEGALEPVFQDEGVDPIAPIAYPPYYSEAMAYLKAVMIKEEMSERAMRLTAYIINMNPAHYTIWLAYRMKVLINLKKDLLQELLWVEQLSKLHPKSYQLWHYRQFLMDMYGDPSMELNFLAEVLQKDSKNYHAWSYRQWLTERFNLWDVELPYIDLFLKQDIRNNSAWNYRFYIVFRDHHYVSDDTMKKEIEYCKDAIAFSPQNSSPWLYLRGILEKYNQNFSFLEPFCLQYASLNPNENQQMSSEALEFLADIYSLNDTSIKDAKKALQLLIDKYDTIRKKYWEYKILLLDRKDDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRK8</accession>
    <name>M7NRK8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00399</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the CKS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872274.1">
        <property type="nucleotide sequence ID" value="XM_007874083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRK8"/>
    <dbReference type="STRING" id="1069680.M7NRK8"/>
    <dbReference type="GeneID" id="19894097"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00399"/>
    <dbReference type="eggNOG" id="KOG3484">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140546_0_0_1"/>
    <dbReference type="OMA" id="RPINYGQ"/>
    <dbReference type="OrthoDB" id="440676at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.170.10:FF:000002">
        <property type="entry name" value="Cyclin-dependent kinases regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.170.10">
        <property type="entry name" value="Cyclin-dependent kinase, regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036858">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00296">
        <property type="entry name" value="CYCLINKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55637">
        <property type="entry name" value="Cell cycle regulatory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00945">
        <property type="entry name" value="CKS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR11373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="115" mass="13923" checksum="303D37DC635C9E54" modified="2013-05-29" version="1">MHESLKKRPIRYLTEAERSRLEEFIENIHYSTRYSDDTHEYRHVILPKPMLKAIPKDYFNQETGTLKILHEEEWRGLGITQSLGWQHYEIHVPEPHILLFKRKYDQQGKHAQQVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRU2</accession>
    <name>M7NRU2_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873972.1">
        <property type="nucleotide sequence ID" value="XM_007875781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRU2"/>
    <dbReference type="STRING" id="1069680.M7NRU2"/>
    <dbReference type="GeneID" id="19895686"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01992"/>
    <dbReference type="HOGENOM" id="CLU_1321373_0_0_1"/>
    <dbReference type="OMA" id="THENDLY"/>
    <dbReference type="OrthoDB" id="1894652at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22209">
        <property type="entry name" value="EMC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39219">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39219:SF1">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21203">
        <property type="entry name" value="ECM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082321" evidence="1">
        <location>
            <begin position="20"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="208" mass="25099" checksum="13F21F26E531F820" modified="2013-05-29" version="1">MEIYIFLWFFLYLFGRTLTHENDLYTKDLNFEIFHELTPETTPVLRGYVKYDFEKEKAVYYHNETLFSFAATWNYMEKGFYRVGAFNSKKKFKNGFIPWIHLKKLLEQDKDIHEEIIIYLDNSNEIWHVDYILSILEKRKNQIPEITTSVRIVFPSSENGVMPIFNKPITLDPDGKPIENKEKTFFQKYWMYIVPLILILLVKNRNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRW9</accession>
    <name>M7NRW9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCT-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00511</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872399.1">
        <property type="nucleotide sequence ID" value="XM_007874208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRW9"/>
    <dbReference type="STRING" id="1069680.M7NRW9"/>
    <dbReference type="GeneID" id="19894209"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00511"/>
    <dbReference type="eggNOG" id="KOG0363">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_6_2_1"/>
    <dbReference type="OMA" id="CAEMVMS"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03336">
        <property type="entry name" value="TCP1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000002">
        <property type="entry name" value="T-complex protein 1 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012716">
        <property type="entry name" value="Chap_CCT_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02341">
        <property type="entry name" value="chap_CCT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="521" mass="56798" checksum="1F506A836DBF38E9" modified="2013-05-29" version="1">MSRIFSEHATEERGENARMSSFVGAIAVGDLVKSTLGPKGMDKILQSASTGEIIVTNDGATILKSIELDNAAAKALVNVSMTQDNEVGDGTTSVTVLAAELLREAERLIDSKIHPQIIIDGYRIAATTALSALCESAVDHKENYELFRRDLEDIARTTLSSKILAQDRDHFSKLAVDAVLRLKSTNLESIQIIKKSGGRLRDSYLDDGFILEKKIGVNQPKRLENAKILVSNTPMDTDKVKVFGARVRVDATSKLAELERAEREKMKAKVEKIKAHGVNCFVNRQLIYNWPEQLFADAGMMSIEHADFDGIERLALVTGGEIASTFDHPEYVKLGRCDLIEEIIIGEDRMIKFSGVAVGEACTIVLRGATSQLLDEAERSLHDALAVLSQTMGDSKVVLGGGCSEILMAKAVDAAASKESGKKAFALEAFGRALRMIPTILASNAGLDSSELISKLRSVHYKGMTSYGLDLINGEIADMRDAGVVESYKLKRSIVSNASEVVEMLLRVDTILRSTPRPRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M7NST4</accession>
    <name>M7NST4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1764 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872103.1">
        <property type="nucleotide sequence ID" value="XM_007873912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NST4"/>
    <dbReference type="GeneID" id="19893932"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00234"/>
    <dbReference type="eggNOG" id="ENOG502SCT1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1768882_0_0_1"/>
    <dbReference type="OMA" id="FTIYNEE"/>
    <dbReference type="OrthoDB" id="20835at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013885">
        <property type="entry name" value="DUF1764_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34066:SF1">
        <property type="entry name" value="DUF1764 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34066">
        <property type="entry name" value="GROWTH FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08576">
        <property type="entry name" value="DUF1764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="17209" checksum="58397B5A2658C30D" modified="2013-05-29" version="1">MKKKKRKNKTYSTELEKSTLLNTNSSSGIYLEILIFKLTIFIDRLKNEINDILKPLKSKKNIESEDKQESIKLNTYKLFGSKSQIKLKRKNEDIDFINLKESAKHKKTEEGFTIYNEEELNIGKGKNTLICPFDCKCCNTTEKSYHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NST9</accession>
    <name>M7NST9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cation efflux protein cytoplasmic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873542.1">
        <property type="nucleotide sequence ID" value="XM_007875351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NST9"/>
    <dbReference type="STRING" id="1069680.M7NST9"/>
    <dbReference type="GeneID" id="19895283"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01588"/>
    <dbReference type="eggNOG" id="ENOG502QV77">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_676389_0_0_1"/>
    <dbReference type="OrthoDB" id="5382797at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="47673" checksum="3B7AC75B6BCF53C0" modified="2013-05-29" version="1">MNINQYSFNCNKNQVSKNSTERNQNAMEALESYVYNYDNIKKFPSNFENKHTSDLINNKSKDGNQYDFLYSLSHKIFNFQSISLFIPTITNILKNTSKNQKNYLILCCSHFIIAFLMWNFKYAPFSSTTLGSIIIYDAVNMLFMFLLNIYEKCEIWHENTIKNPFGLKRVEVLGKFSIAIFSLYITINSFKNIIEESILDSFSEKNILKKSEFSQITLIFSFITIVISIIMTTISTIYFNNRFHLSKGIFSSSTVFPTLLNPFYLKSLLPLFIFLFMILVSPSTINTLDKYISLLFEIPMCILRYIIIKKLGGILILSFSEENVQTCIKELEKETLIHSIKLAYIWQPYFSFYIASFNISTKSDESMNFKIQEFINNILYRNFKKVINNHENENVWEINVSIERISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NT18</accession>
    <name>M7NT18_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PLD phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01143</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873057.1">
        <property type="nucleotide sequence ID" value="XM_007874866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NT18"/>
    <dbReference type="STRING" id="1069680.M7NT18"/>
    <dbReference type="GeneID" id="19894840"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01143"/>
    <dbReference type="eggNOG" id="KOG2031">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007773_2_0_1"/>
    <dbReference type="OMA" id="FPPMDGQ"/>
    <dbReference type="OrthoDB" id="47785at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09122">
        <property type="entry name" value="PLDc_Tdp1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF4">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="4">
        <location>
            <begin position="375"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="3">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR10427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="462" mass="52744" checksum="3E352070847DB2E6" modified="2013-05-29" version="1">MISENSKKDCYYFASLEEDITNENFTESSNRFSKKLCLENSNIQAKSFEETKELVNIQNIPFPNGTVKITAVKGYKRTEHDITIEDVFQKESLKAAVLSAFVIDPLWVLTKIQLFNTIIIFVHQAKSDEEEVINRLYLHIPNVSAIFPPMEGANCMHCKLQLLFYTTYLRVVIPSANLVDYDWGETGTMENSMYIQDFPRRITVFTGFSTDFERDIFHYCKIKNYPQHVLEKMKNYDFSLSKNLQFIHSIPLKAQKNSDLKDTGYVSLAKAIQQLGKRHENDIKIDIMTSSLGLLNSTFLSNMYLALKGSKVVASRNTDIQAWKTSMKIHFPSMNTVLSSNGGEESAGTICFQKRFWEYLKFPKSILYDSTAVHVGCLMHHKIILVRNQTSTSDFFYIGSANFSSSAWGVLTRLNSKNPVILCRNWECGVILSLNDHYSCIIEAILSETSSLPNSTPWISNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M7NT55</accession>
    <name>M7NT55_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01176</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873091.1">
        <property type="nucleotide sequence ID" value="XM_007874900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NT55"/>
    <dbReference type="GeneID" id="19894873"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01176"/>
    <dbReference type="HOGENOM" id="CLU_1434981_0_0_1"/>
    <dbReference type="OrthoDB" id="5355726at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018305">
        <property type="entry name" value="Ribosomal_m50"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10501">
        <property type="entry name" value="Ribosomal_L50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="189" mass="21943" checksum="AA8645FBCED369DD" modified="2013-05-29" version="1">MTPYKVIFNGYLYFIDIGLLNKSKLLSINHCIRHLNMSSKQVQQTDQEEGKEIFKVPKELQFSERKRYRCSFESLNGFKISPYGRKKPIKNIERLEKAVRTAISRSTGGTYDGSSPIILTEDLSFKLRMIQALYKETGHRLPDNVVTKAKNVSTILKYYKKAIDELKRKKNEPPVNKQLFKGTNVYIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NT77</accession>
    <name>M7NT77_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein EFR3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873117.1">
        <property type="nucleotide sequence ID" value="XM_007874926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NT77"/>
    <dbReference type="STRING" id="1069680.M7NT77"/>
    <dbReference type="GeneID" id="19894897"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01200"/>
    <dbReference type="eggNOG" id="KOG1877">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RHSIFFC"/>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039786">
        <property type="entry name" value="EFR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049150">
        <property type="entry name" value="EFR3_HEAT-like_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766:SF1">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21072">
        <property type="entry name" value="EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="843" mass="96308" checksum="2430510FF51EC6FA" modified="2013-05-29" version="1">MNIFFKTKHTKLVLRCYPKSQVSEHKPNSSELSYLCYYGFTRPSKLQKVGLFLERKLSKDVYRRKQGDIIVSLYICKALIERCHKDLNLYAANVVNILNSVLRSGDVEAIEHSIDCFTSFISHHNGLILSSDENYAKQFNILITAFVDFAMAQSGPKMTRYRLVGMQAAQAITSSEAIQNSNLLYLTAKIIPGILHNLQHKNEEFLLRFQSKTENFHKTENHIDPVSYTSKTINEDDQLEDELNEILALENLKRIYEINDGAHIKNATLALISHIRSLTKNKSIINWAVTLITMITRWTHVQHRYIILIITVEILESLPDKDIPSKEYFLLTSLIHALLSSNVNLIGLSVMDIIHALTGKIIGQIKELDTPNTARLSKVILSKRSYLLEGNTIGHKFNSEQREFFISELIHCLGALATHIYYRDQITDMTASFLNCLKPFSNASSASANEVRIGKLLALAAVREIFVIVNLKCNQSGVSRSRVSLDIWNYTAVVLKDSDPILRLEYISVLTTFLNIEFNSPDEESLYSFDTSKTSFSNYLQSLRSYIYIYFLLSNNTETDYQAIQYLLFILTEKFGPKETIRLIPVILRLQQSIDEENINLSLQQKSTILSIVIWYMIIVSKKINNQKLFEKVNEEMNKRKLDKSWPDFITLHPSFIPSSICSPQPLSKTIAPSKPFLNKEEIISILILYTPKFPENAKKYITETWTPESSLILEDFSRSDSLVGMNSVNYKKHLSPSNSLSQITLNQEEILQNNIHSSLKTSSLKRTLTEPNINNIKTSFNISKNKLNKFKSSDKFTQKDTDKFNQNAIQKIDMNKLLDNISLKALSNSKKHSKISASAPYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTR8</accession>
    <name>M7NTR8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MAGE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873135.1">
        <property type="nucleotide sequence ID" value="XM_007874944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTR8"/>
    <dbReference type="STRING" id="1069680.M7NTR8"/>
    <dbReference type="GeneID" id="19894915"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01218"/>
    <dbReference type="eggNOG" id="KOG4562">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048908_1_0_1"/>
    <dbReference type="OMA" id="KITYSWG"/>
    <dbReference type="OrthoDB" id="205198at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1200">
        <property type="entry name" value="MAGE homology domain, winged helix WH1 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1210">
        <property type="entry name" value="MAGE homology domain, winged helix WH2 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037445">
        <property type="entry name" value="MAGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041898">
        <property type="entry name" value="MAGE_WH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041899">
        <property type="entry name" value="MAGE_WH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002190">
        <property type="entry name" value="MHD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736">
        <property type="entry name" value="MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736:SF14">
        <property type="entry name" value="NSE3 HOMOLOG, SMC5-SMC6 COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01454">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01373">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50838">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAGE" evidence="2">
        <location>
            <begin position="63"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="304" mass="34732" checksum="E7057FCEA9898922" modified="2013-05-29" version="1">MKTRQKHVTESKIKRNKNIFEKGSKSMLQSSSQNKESNISTGETSRQMENNLSVKNTINDEDLNLMVKNFIRLALALEHNRTPIKKEDISKKVLLPSHSRSFAIVFEKTQEKLRNVFGMELVELPYKNNCKHISTSHLRKNQNFQTHNPFSIAHLNKSWILCSILDPKYSDLIFEVPTIKEGIFSGIVMTILSILIMNGGEISNELLIRYLSQLQMDNDTSIGNLDKTLKEMVKKGYLERIKDDITSANEGEKNYTYLLGPRGKTEIDPESLTTFIKKIQGDAAPQNLKEIVKKLFNKSISSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7NU75</accession>
    <name>M7NU75_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873295.1">
        <property type="nucleotide sequence ID" value="XM_007875104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NU75"/>
    <dbReference type="STRING" id="1069680.M7NU75"/>
    <dbReference type="GeneID" id="19895063"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01366"/>
    <dbReference type="eggNOG" id="KOG0676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025520_0_0_1"/>
    <dbReference type="OMA" id="WERDNDN"/>
    <dbReference type="OrthoDB" id="337660at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10207">
        <property type="entry name" value="ASKHA_NBD_Arp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="418" mass="47537" checksum="36B47F8DA182333D" modified="2013-05-29" version="1">MSLPHSFILQLSSEDPLQHSSYSNRLKTLYELEPYIVLDIGSHYLKAGFSGESFPRCTIEYDERSFLGYRCTLAENITRFPVNFEYLLWDEPNLELIGDRLEIYLREVYNKWLNIGSKFRKVSIVEYILLPIKFKVIIAKTLFTYFQVPSITFLSSHVLVLVSLGLNSGIVIDIGSKETSVLPIYDLRPMTSFIVTSSLASNICFSRLKYLLIHYSTPRLESLTFYDVQDFLQRAVFSLPLSPLTSSKSTIIFPENLENIYKPNVECSDVIWEPPSQKGLEVTIPGWVRVCITEALFEASDKYADTDEISIPQMIKKCLSHLPIDIRSIVSTSLVISGGFSLIPGLQNRINNEIKASGKVIRNEFGVNAAWVGASLLGDLKIEGLYEITRENFIKKMRVPDWSISFEDESHTSKVYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUC0</accession>
    <name>M7NUC0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U4/U6 snRNA-associated-splicing factor PRP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_01034</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a recycling factor of the spliceosome, a machinery that forms on each precursor-messenger RNA (pre-mRNA) and catalyzes the removal of introns. Chaperones the re-annealing of U4 and U6 snRNAs (small nuclear RNAs) released from previous rounds of splicing, an initial step in reforming the U4/U6-U5 tri-snRNP (small nuclear ribonucleoprotein) that can reassemble into another spliceosome complex; this step involves binding U6 and facilitating the unwinding of the U6 internal stem loop, followed by base-pairing of U6 to U4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872947.1">
        <property type="nucleotide sequence ID" value="XM_007874756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUC0"/>
    <dbReference type="STRING" id="1069680.M7NUC0"/>
    <dbReference type="GeneID" id="19894732"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01034"/>
    <dbReference type="eggNOG" id="KOG0128">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003925_0_0_1"/>
    <dbReference type="OMA" id="LWARYIL"/>
    <dbReference type="OrthoDB" id="360390at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12299">
        <property type="entry name" value="RRM4_Prp24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000365">
        <property type="entry name" value="U4/U6 snRNA-associated-splicing factor PRP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031766">
        <property type="entry name" value="RRM_occluded"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204">
        <property type="entry name" value="PRE-MRNA PROCESSING PROTEIN PRP39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204:SF25">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16842">
        <property type="entry name" value="RRM_occluded"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="579"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="655"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="746"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="863"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="512"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR10887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1011" mass="119389" checksum="BF661D9E03E543B1" modified="2013-05-29" version="1">MNINSEENFIKDEEMSVDNDFDISKDLEEINTLLDKLMKQPFDYDSHIKYINLLKKHKMTDELRSAREAMQVYFPLTEEMWIEWLDDQEELALTSDDKISLLELYSKSVEDYLSINLWKKYITYVRTQVEMASSNEKSDLKELFNQNFLENIYLQAYSATKYHILQSNEIWSIYRDYKVQMLKENPSLENIQDVKQIYIERLKIPHFGMETCFSDFSSFITNYDNTNYEEIMVSTNKIYSPALVKYQERDFHEMELSKYNYAYDQYVKYLEWELHQKPQEIGLICTLFERFLKSYPLSADIWEDYTQFMFEKSSINKINDFFLQRSVKNYPWSGMLWAHYIYVLEHNNSSLSEICSLKNRSIELGTLFHDVEEFVKVLEAWCGYCKRRVIVWDNNDEKVQYVIKELQTSIKLLKNVFKTSDRQKRLEKMLISINTKLGNMNEARKIWKNILKNHNTETKYWLQYFIWERHYGEINIAMNILKNASLKHLDFPELIFDIYRDFVIEEGTLESLEKAETIIHKGTRNIRKIKEKEINIQNKNNQLFEESKEKLEEIPTDDNINNQKKTKIENKIKRNRENTTVRVTGLPKPVSVEQLHHFFCGCGDIIDTKIMEESSKDSSTAFVEFATLEDTKCALTKNYKKLNQKEILVELATETTLWVTNFPPSADEKFIYQLFQEYGDVVEVRFPSLRYNSRRRFCYVQMKYPEQALASLSLHGQTFEKKYKLVVSISDSSKKENRKEATSEGRKIIVSNISPESTEDNLINLFSKYGTIERIRLIYDRNSEYHKGFCYIVYATAEQAYSALDADKQELHSKPISVKFVGVKNKDHLKKNRKNEEDISLHESTVSEEKTKPALSFHEIKDKSLGILYLPDTVNQTRIEDVFKTYGSINKIELRPDHQGAIVQYKHASDAGRAAMALDGYVFSDRKIRIVTVETLLQHNPKKISLQNPDLVLPKITDPKPRRQRLSINENPISLPKKRLKISTQNNDSSYIQSLSTYNNDDFRSMFLNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUX4</accession>
    <name>M7NUX4_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01058</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872970.1">
        <property type="nucleotide sequence ID" value="XM_007874779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUX4"/>
    <dbReference type="STRING" id="1069680.M7NUX4"/>
    <dbReference type="GeneID" id="19894756"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01058"/>
    <dbReference type="eggNOG" id="ENOG502S9K4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_676387_0_0_1"/>
    <dbReference type="OMA" id="HANAPIL"/>
    <dbReference type="OrthoDB" id="312015at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021622">
        <property type="entry name" value="Afadin/alpha-actinin-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11559">
        <property type="entry name" value="ADIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="67"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="407" mass="47011" checksum="4014155F7224F2E8" modified="2013-05-29" version="1">MNISEDLPSGILYINNALASRGLLPDENQRILHFNSSDSHEVIKIIYNLLNKGDKDIAIHEDSLRKLKEIQAQNEKYSYQLNNTKSKLEEAEREINSLKKKLNYLNKELSAALIEKKSTKDYISKIKNSIVYMKSQYANDLRKRDQQLLRLKEYLLGSELSKRNKNLSTMQIQKNSTLHKGPIYTPSLAIEDTTITEKLSEEAFSNLLLFSQKVSNVNIQLNNIIFQVLSDLDYLIGTKEDSEPLFSSSSSPTILEAQLQVRLKLLSDIVFRSNNAPLVETEAKDQEIYFLKQEIQKLNDNWEETKEFLGNFQKSLFGNKDNYVKEWEDQIDKNISDENISPILQEQKKGLINNYKLLSLEDNKMESFFNDSKNVTNTNILSFQKENALQQELEEVLGLLPKTPMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NV05</accession>
    <name>M7NV05_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable methionine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="2">6.1.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_01101</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873013.1">
        <property type="nucleotide sequence ID" value="XM_007874822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NV05"/>
    <dbReference type="STRING" id="1069680.M7NV05"/>
    <dbReference type="GeneID" id="19894798"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01101"/>
    <dbReference type="eggNOG" id="KOG0436">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009710_9_0_1"/>
    <dbReference type="OMA" id="MDTQAFC"/>
    <dbReference type="OrthoDB" id="24670at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.220.10:FF:000001">
        <property type="entry name" value="methionine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="METHIONYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="11">
        <location>
            <begin position="44"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="436"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR10956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="562" mass="65759" checksum="063135C569DE87E7" modified="2013-05-29" version="1">MLIFRKKIIKNYMKLIYMDPYLYMLLQCRLIFSRKNSSLAGKTYYITTPIFYVNSDPHIGHLYTLVLADVIQRYIQLKDRSVILRIGTDEHGIKVERAALKSGLNPPLFCEKMSERFKYLAKLANIDHKGFTRTTDPKHCQSVRCFWKVLKDKGYIYESKHEGWYASRDETFYPSIAVKKIQNSDGTMSTISIETGAHVEWTSENNYHFRLSKFTNQLLDHYRKNPCFIIPRSEQNNLYHIIEQGLSDISISRPSSRYSWGIRVPEDESQTIYVWFDALLSYITSAGYPWSNSMLGEWPANIHLIGKDILRFHCVLWPALLLAADLPLPYQIVSHSHWTMNNIKMSKSLGNIVDPFTKIQTFGADPVRYFLIKEGRLESDKNYDLSDFIRNYNVDLRGKLGNLLLRVCSPHFDLKRALLCSKEYVDKNTLFQEFDTNINTIAEKVDDHMSKFQLHAALQSIFHFIAIINKFFQDFEPWKYCNHPDKVDPVIYRTLEAIRLSAILLKPFIPEKASEILDQLDVQPSRRSFKFCKLGLDKTYLQTQCKRNMLLFPKLSSMYLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVH8</accession>
    <name>M7NVH8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_00310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872184.1">
        <property type="nucleotide sequence ID" value="XM_007873993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVH8"/>
    <dbReference type="STRING" id="1069680.M7NVH8"/>
    <dbReference type="GeneID" id="19894008"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00310"/>
    <dbReference type="eggNOG" id="KOG1620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042569_3_0_1"/>
    <dbReference type="OMA" id="FRICGMK"/>
    <dbReference type="OrthoDB" id="338650at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000827">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000825">
        <property type="term" value="F:inositol-1,3,4,5-tetrakisphosphate 6-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000823">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 6-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000821">
        <property type="term" value="P:regulation of arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF103">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE MULTIKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR11282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="301" mass="33701" checksum="98694DB033D43388" modified="2013-05-29" version="1">MASSFIPYVHQTAGHEGVLSDKSGIIICKPCIPAEVAFYTMAQAFPAFQRWMPTYMGNLTLQSSSESANKSSLGSDAIVLENLCYPFVRPCTIDVKLGSRLWDDDVSPEKRKRLEEVSKHTTSGCLGFRVSAMRIWNVNEATYQSYSKEWGKSLTASTISEGLNKFLSAVEAKEQRLRIVSEWINSLTQIQEVLSKVEVRMYSSSLLFIYEGDPEVLMQRIKQLDVAKQNIEELDIETQSSNNSTDSINSEKNCNIPHISVCRLIDFAHAHWVVGQGSDENVLHGIASLKTILMKISSEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVQ2</accession>
    <name>M7NVQ2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00805</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872712.1">
        <property type="nucleotide sequence ID" value="XM_007874521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVQ2"/>
    <dbReference type="STRING" id="1069680.M7NVQ2"/>
    <dbReference type="GeneID" id="19894503"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00805"/>
    <dbReference type="eggNOG" id="ENOG502S4TA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1078166_0_0_1"/>
    <dbReference type="OMA" id="ERTYTSH"/>
    <dbReference type="OrthoDB" id="5970at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12467">
        <property type="entry name" value="RRM_Srp1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034403">
        <property type="entry name" value="Srp1p_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="5"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR11216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="258" mass="30323" checksum="68998621002A4351" modified="2013-05-29" version="1">MTRRQTLYVTGFSSDIRAKDLAYKFEKFGRLVRCDIPVPRKVGARPFAFVEYEDSRDADEAYHDLHGLRMGRDTLSIEWAKKSPSASWRFDERTYTSHRRGRSSSRRRHRSYSRSYSDSRSRSRSRSRYNHHRRHRCSHYSRSRSRARGRRHTRSRTRSRTRSHTRSHSRTRSRTRTRSRCRSRSYSRTRSCSRPSPQCPFEAVKQDNKAELPIQNVPSPVDNTVELSASTLKNDDSQQTTNGMSIQTNNISETVTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NW23</accession>
    <name>M7NW23_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S ribosomal protein S28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872408.1">
        <property type="nucleotide sequence ID" value="XM_007874217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NW23"/>
    <dbReference type="STRING" id="1069680.M7NW23"/>
    <dbReference type="GeneID" id="19894218"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00520"/>
    <dbReference type="eggNOG" id="KOG3502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_178987_1_0_1"/>
    <dbReference type="OMA" id="NTGMHGE"/>
    <dbReference type="OrthoDB" id="10258930at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04457">
        <property type="entry name" value="S1_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000025">
        <property type="entry name" value="40S ribosomal protein S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00292">
        <property type="entry name" value="Ribosomal_eS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_eS28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028626">
        <property type="entry name" value="Ribosomal_eS28_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00961">
        <property type="entry name" value="RIBOSOMAL_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR11507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="67" mass="7624" checksum="42F27758CE0F051D" modified="2013-05-29" version="1">MDAKQPVKLARVTKVIGRTGSRGGVTQVRVEFMDDTTRSIIRNVKGPVREDDILCLLESEREARRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7P2V1</accession>
    <name>M7P2V1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WHIM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_03361</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875443.1">
        <property type="nucleotide sequence ID" value="XM_007877252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P2V1"/>
    <dbReference type="STRING" id="1069680.M7P2V1"/>
    <dbReference type="GeneID" id="19897048"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03361"/>
    <dbReference type="eggNOG" id="ENOG502QSZU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_608477_0_0_1"/>
    <dbReference type="OrthoDB" id="349045at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028942">
        <property type="entry name" value="WHIM1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107:SF1">
        <property type="entry name" value="WHIM1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107">
        <property type="entry name" value="YALI0D24453P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15612">
        <property type="entry name" value="WHIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WHIM1" evidence="4">
        <location>
            <begin position="137"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="450" mass="50866" checksum="58F038E13C8A0DC3" modified="2013-05-29" version="1">MSDSSELSSPPSSLHSVILKESDNDLSPVKSESVSMASSTSSPDESDINESFISSLDIAYIVAFRNRFSQLFEGIPDLGPQDIERGIFGEPEALDKIVELLCRLVTLCLNRKRAVESKHFSRALSESVDVHIKHLDPSWCGYNPLHKEKGFYSLCASDKLKLLCCLVDWCLMSSEVVRSFIDENYKNRASDDKKNALLVHPLGKDGKNRKLWLIEGNDTPFRVYRESKSRSGFVKWKSIAGTADELRQYALSLSNDSSLNAIALVPKILEQVCPRVEKAQIRRDKLEANRARLASLNIESTLLGMRTRGKRIKYTFSDNDDSDNDIRTSSFKHKDCFDSNKSIQYTASGRMIKRPKRGDCGIYEEIDMAESSNFRKIENIELSKNSFQDDNYVEFESGYHTTSTSSESESGTFSLKVLLKYNPKKLVTGLSDFSETFIEHDHLLNKNPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7P395</accession>
    <name>M7P395_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c oxidase assembly protein COX19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_03449</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the assembly of mitochondrial cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the COX19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875537.1">
        <property type="nucleotide sequence ID" value="XM_007877346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P395"/>
    <dbReference type="STRING" id="1069680.M7P395"/>
    <dbReference type="GeneID" id="19897136"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03449"/>
    <dbReference type="eggNOG" id="KOG3477">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141947_5_1_1"/>
    <dbReference type="OrthoDB" id="268594at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051383">
        <property type="entry name" value="COX19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHCH" evidence="7">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="67" mass="7743" checksum="F16D013117ABF39E" modified="2013-05-29" version="1">MGFIQISKTLLTPPLYGSFPLDHDGECTSLMKAYLHCLQTHHYEQSQCKNMAKVYLQCRMDRFAKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7P4A9</accession>
    <name>M7P4A9_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02863</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PurH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874900.1">
        <property type="nucleotide sequence ID" value="XM_007876709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P4A9"/>
    <dbReference type="STRING" id="1069680.M7P4A9"/>
    <dbReference type="GeneID" id="19896550"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02863"/>
    <dbReference type="eggNOG" id="KOG2555">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016316_3_2_1"/>
    <dbReference type="OMA" id="IKHNNPC"/>
    <dbReference type="OrthoDB" id="6017153at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01421">
        <property type="entry name" value="IMPCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.20:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000001">
        <property type="entry name" value="Bifunctional purine biosynthesis protein PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024050">
        <property type="entry name" value="AICAR_Tfase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005492">
        <property type="entry name" value="PRK07106.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692:SF0">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="10">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR08685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="589" mass="66251" checksum="84364C765355FF6F" modified="2013-05-29" version="1">MEKKKIAILSVYDKTGLFDLVKGLTQHNIKLLGTGGTSKMIRDAGYDISEVSSVTNYPEILGGRVKTLHPLIFGAILARDLESDEKELELFNIDKIDYVICNLYPFKETILKQNITVAEAIEKIDIGGVTLLRAAAKNHIRVTVLSDPNDYSSFLEELRRGGISQESRNRFALKAFSYTSEYDIDITNYFRKQYTSNQMQLSLRYGINPYQTSSKAFVHSGNIPFKVLCGSPGYINLLDALNSWPLVKELSEALNLPAAASFKHVSPAGVSIGISLSEIEKKVYFVEDISDLSPLACAYARARGADRMSSFGDWIALSAKVDLPTARIISREVSDGVIAPAYEEDALEILKKKKNGKYCILQMNYDYEPPLIETRQVYGISLQQRRNDVKINEETFRNIVSNNKTLPNDALIDLIVATITLKYTQSNSVSYAKNGMIIGLGAGQQSRIHCTRLAGAKTKNWWLRHHPKILKFNFHSYIKRPEKSNAIDLYIQNKIPNSGPEKKQWESVFVTIPEPLSDKEISEFMEKLNDVACASDAFFPFPDNINELSKYNVKYISAPGGSIKDKEIFETADQFGMVFVNTNLRLFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7P4G9</accession>
    <name>M7P4G9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS10m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">37S ribosomal protein S10, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02905</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874945.1">
        <property type="nucleotide sequence ID" value="XM_007876754.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P4G9"/>
    <dbReference type="STRING" id="1069680.M7P4G9"/>
    <dbReference type="GeneID" id="19896592"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02905"/>
    <dbReference type="eggNOG" id="KOG3321">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051208_2_1_1"/>
    <dbReference type="OMA" id="YHAPLRV"/>
    <dbReference type="OrthoDB" id="366214at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000003">
        <property type="entry name" value="30S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="6">
        <location>
            <begin position="100"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="208" mass="23964" checksum="D34007226CC65052" modified="2013-05-29" version="1">MHILNKIHISSLLSSSIYTCNISEITDIVRKKYTDKTTNLLGILHSIRTIHLVKNNETLQTKSFKASLSIEDISKLPQNVQAAYLEPLRHPARYGIITCSLQMRSFEVPRLAFFADFSMRVAYYLGLPASGPVPLPKRIERWTVPRGPFIHTKSKENFERITHKRLITIKDGHPRVVEIWLAYLKKHAMSGVGMKANVFHWEPMEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7P4N7</accession>
    <name>M7P4N7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin-activating enzyme E1 1</fullName>
            <ecNumber evidence="4">6.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_02945</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.45" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874990.1">
        <property type="nucleotide sequence ID" value="XM_007876799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P4N7"/>
    <dbReference type="STRING" id="1069680.M7P4N7"/>
    <dbReference type="GeneID" id="19896632"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02945"/>
    <dbReference type="eggNOG" id="KOG2012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002556_0_0_1"/>
    <dbReference type="OMA" id="GANLHAF"/>
    <dbReference type="OrthoDB" id="10252231at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004839">
        <property type="term" value="F:ubiquitin activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01491">
        <property type="entry name" value="Ube1_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01490">
        <property type="entry name" value="Ube1_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2660:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12550:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000015">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.180:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.60:FF:000002">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.180">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, FCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.60">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, UFD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042302">
        <property type="entry name" value="E1_FCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018965">
        <property type="entry name" value="Ub-activating_enz_E1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038252">
        <property type="entry name" value="UBA_E1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018075">
        <property type="entry name" value="UBQ-activ_enz_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01408">
        <property type="entry name" value="Ube1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF4">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09358">
        <property type="entry name" value="E1_UFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00985">
        <property type="entry name" value="UBA_e1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-activating enzyme E1 C-terminal" evidence="12">
        <location>
            <begin position="887"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR08775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1019" mass="115812" checksum="4C2A33018D671D0B" modified="2013-05-29" version="1">MSKMQIDEQKPLDVVDHLIDEGLYSRQLYVLGHEAMKRMSISNVLIVGLKGLGCEIAKNICLAGVKNITLYDPTPIQIEDMSSQFFFKHRDIGKPRDQVSVPYLSELNRYVLVNFLKEEFNYHVLDKFQIVILTETSLKRQIEINDYTHEHGIYFISTDVRGLFGYIFCDFGKDFYIFDTNGENPIMGIISSISQDGIVTVLDETRHGLEDGDYVTFKEIKGMEALNMSSPRKIQVKGPYSFSIGNIDNIGEYKGGGIFVQVKMSKKIQFKSLRESIVSPSFLTNDYSKLDRPLLLHIAFQALYSFLEDYRRLPKSRNEEDAEIVYTIAKIISSKYSKELKLDERVIKEVAYQARGDLNPMAAVFGGLAAQEALKAISGKFTPIQQYMYFDSLESLPTSCRLTEESCSPINSRYDGQIAVFGKDFQQKISNFREFLVGTGAIGCEMLKNWAMLGLSTGPKGKIYITDMDTIEKSNLNRQFLFKSKDVGKLKSECAAAAVIQMNPEITEKIVTYTERVCPETENLFDADFFESLDGVTNALDNVNTRIYVDQKCVFYRKPLLESGTLGTKGNTQVIYPYLTESYSSSRDPSEKSFPICTIKNFPNQIEHTISWARNLFEGYFRQPAENVNLYLSQPNFIQELLKQSGSQKDILEIIQSYLVTSKPLTFEECIVWARLEFEKKFNNDIQQLLFNFPRDSITSNGVPFWSGPKRVPTPLIFDINDEQHLAFIIAGANLHAFNYGLKGEVDRGIYKRVLDNIIVPDFSPKAGIKIQENDSDPNIEIGTKADSSELNNLISCLPLPSTLAGYRLNPVIFEKDDDTNYHIDFITAASNLRALNYGIETTTRYNTKLIAGKIIPAIATTTALVSGLVCLELYKIIDKKNKLEDYRNSFLNLALPFITFSEPIASPKLKYNNKEVSQIWERFDIYGDITLQELLLHFKNNEGLTITMLSSGVSLLYASFFPEKKHQERRPMRLTQLIELVSKKPVLENKKTILLEICADDEQGEDVEVPYICVHLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7P500</accession>
    <name>M7P500_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U6 snRNA-associated Sm-like protein LSm1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LSM1</name>
        <name evidence="8" type="ORF">PNEG_02706</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the heptameric LSM1-LSM7 complex that forms a seven-membered ring structure with a donut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874731.1">
        <property type="nucleotide sequence ID" value="XM_007876540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P500"/>
    <dbReference type="STRING" id="1069680.M7P500"/>
    <dbReference type="GeneID" id="19896397"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02706"/>
    <dbReference type="eggNOG" id="KOG1782">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_0_1_1"/>
    <dbReference type="OMA" id="DQFANLM"/>
    <dbReference type="OrthoDB" id="10263346at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01728">
        <property type="entry name" value="LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034104">
        <property type="entry name" value="Lsm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF8">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="7">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="114" mass="13271" checksum="829DF3DA2C9F05BA" modified="2013-05-29" version="1">MVILRDGRKLIGILRSFDQYANLVLQETIERIYVDQVYGDIPRGVFIVRGENVVLVGEIDQNKKNDLNLKEVSAIEAFNKQKIQNDLRKAKEKVQCRALYQLGFSVDHYHDDMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7P5M5</accession>
    <name>M7P5M5_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">tRNA modification GTPase TrmE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_02520</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874530.1">
        <property type="nucleotide sequence ID" value="XM_007876339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P5M5"/>
    <dbReference type="STRING" id="1069680.M7P5M5"/>
    <dbReference type="GeneID" id="19896212"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02520"/>
    <dbReference type="eggNOG" id="KOG1191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019624_3_1_1"/>
    <dbReference type="OMA" id="EFHCHGG"/>
    <dbReference type="OrthoDB" id="188276at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070899">
        <property type="term" value="P:mitochondrial tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14858">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.120:FF:000007">
        <property type="entry name" value="tRNA modification GTPase GTPBP3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="entry name" value="tRNA modification GTPase MnmE domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00450">
        <property type="entry name" value="mnmE_trmE_thdF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003661">
        <property type="entry name" value="PRK05291.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714:SF2">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116878">
        <property type="entry name" value="TrmE connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="GTP-binding protein TrmE N-terminal" evidence="8">
        <location>
            <begin position="21"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="MnmE helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="7">
        <location>
            <begin position="238"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR09180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="484" mass="54607" checksum="F7579DBD94C5CD46" modified="2013-05-29" version="1">MFFLPLLKDIPLYHSSYVFKTIYALSTPLGKSAVALIRISGPESFRVVQALCPSRKLPKLRYMSLREIRHPKTNELLDKACVLLFKGPFSFTGEDMAELHVHGGPAVIRAVLDAISSSDCNVQYAEAGDFSRRSYENGKLDLTQAEGLYDIINAETEEQRKLAVRQVEGFLKSLYDGWRDELIDYRSHLEAIIDFGEDDDINDNIYFQIYKKVEKFVIRVQDHLKESVRCELLRHGIKVSIFGLPNVGKSSLLNIIAKRSVSIVSSEPGTTRDIIDVVVDIGGFPVIFSDTAGLREENSLGFVEKEGIKRAYENIEKSFMRICVLDITDIEANVSSLRYLLIHQNTSNQQIILVLNKIDLLDSEKYMDLKKIEFLTGISSSFIFPVSCNTNAGIRDLIFSINNQLRKLILFENSQEVVGANARHREHLEKCLGHLQIFLNGNIKDIVIGADNLRYASDELGKICGRIDIEEVLGAIFSKFCIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7P5W0</accession>
    <name>M7P5W0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874589.1">
        <property type="nucleotide sequence ID" value="XM_007876398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P5W0"/>
    <dbReference type="STRING" id="1069680.M7P5W0"/>
    <dbReference type="GeneID" id="19896266"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02574"/>
    <dbReference type="eggNOG" id="KOG2950">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024456_1_0_1"/>
    <dbReference type="OMA" id="GENTNFY"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039905">
        <property type="entry name" value="CD2BP2/Lin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138:SF3">
        <property type="entry name" value="CD2 ANTIGEN CYTOPLASMIC TAIL-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138">
        <property type="entry name" value="PROTEIN LIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="307"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="365" mass="43808" checksum="8986F9CE24CC061E" modified="2013-05-29" version="1">MNHIRVGTALNLEEDKLLEADLNTKKQNKKRVWTEGYDSDSSQDDRIREERDEIDIFEENERIQSEGNEKEYKNGRIYTEKRGKKTRFVELEEIEGQDFDSRREFVDILDEDDEEDDEDYDSELGASGRKKNPPKIEAFNMKADFEEGRFDEEGNYIRNAPDLNAKHDIWLEGIRREDILRARKAMEKKEEEDRLLLEKKEELSLENMYETLLSLLEVGETILEALQRLGEGLEQKKRWTNKNKKDLQQLKNEETQKKYRDIERITELADKLMQYGHNEIYDLTREAIARKYQKETGKVWKNPRKEELKYEYKWEGKDEIYGPYERLQIKEWHDRGFFTEQKIEIRKIGDQVFQTLEDLGFSFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7P643</accession>
    <name>M7P643_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02273</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874264.1">
        <property type="nucleotide sequence ID" value="XM_007876073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P643"/>
    <dbReference type="STRING" id="1069680.M7P643"/>
    <dbReference type="GeneID" id="19895966"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02273"/>
    <dbReference type="eggNOG" id="KOG0773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1205201_0_0_1"/>
    <dbReference type="OMA" id="NQLNMWF"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="5">
        <location>
            <begin position="146"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="148"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="230" mass="27083" checksum="4DF166A7830C8C65" modified="2013-05-29" version="1">MSREPYEVFFEEIMDDETFYKSETKIERLMFRRQMLLKLINQVIDIRDDLLYSCHGQNNKELSETINRLKEVLKLVGDLKTEKKFDSSESILVSGIYHLSIQIAYLSDLCRNVFSEISLASQRYQYDLVSNISKTNKLPLSTISNSSRPKHSTHHPENRTRLLKDWFLEHISYPYPNKDEKRLLCRLTGLKINQLNMWFINARRRSNGGLKFKEQVVSDNLVPLVFANSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6Y7</accession>
    <name>M7P6Y7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="16">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PNEG_02238</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16 18">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the dus family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="16"/>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874222.1">
        <property type="nucleotide sequence ID" value="XM_007876031.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P6Y7"/>
    <dbReference type="STRING" id="1069680.M7P6Y7"/>
    <dbReference type="GeneID" id="19895931"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02238"/>
    <dbReference type="eggNOG" id="KOG2335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013299_5_1_1"/>
    <dbReference type="OMA" id="NPCLFAN"/>
    <dbReference type="OrthoDB" id="272303at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106414">
        <property type="term" value="F:mRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102262">
        <property type="term" value="F:tRNA-dihydrouridine16 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102263">
        <property type="term" value="F:tRNA-dihydrouridine17 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 16 18" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="19">
        <location>
            <begin position="19"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="21"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMR09655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="326" mass="37479" checksum="1BDBEBDF242DD76D" modified="2013-05-29" version="1">MGLRCREFWNSIGSPSRIVAPMVDQSELAWRILSRRYGADLCYTPMFHAKKFWSSPQYRKNVWSTLDNGEDRPLIVQFCANDPEDFLKASRIVIGKCDAVDLNLGCPQKIAKRGYYGAYLQENWDLISKIIKHVNESLDIPITAKIRIFSDKEKTLAYAQMIIEAGVSILAVHGRTREQKGNLTGLSDWNQILYLRENLPSDIVIFSNGNILWPHDVDKCLKETKVDGVMSAEGNLYNPSIFNRSDTRSIITEIAKEYLDIIVNYGLENDKSCINAVKPHLFKILRTGLSKYAHFRNELREVKSNELKKCFKIVEELDILVKVFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M7P7J6</accession>
    <name>M7P7J6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Brl1/Brr6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873986.1">
        <property type="nucleotide sequence ID" value="XM_007875795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P7J6"/>
    <dbReference type="STRING" id="1069680.M7P7J6"/>
    <dbReference type="GeneID" id="19895700"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02006"/>
    <dbReference type="eggNOG" id="KOG4503">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040960_0_0_1"/>
    <dbReference type="OrthoDB" id="5961at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040202">
        <property type="entry name" value="Brl1/Brr6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018767">
        <property type="entry name" value="Brl1/Brr6_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136:SF1">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10104">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01042">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Brl1/Brr6" evidence="2">
        <location>
            <begin position="191"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="370" mass="42164" checksum="7EC808B7A61DCF3A" modified="2013-05-29" version="1">MMRSEESPMDFTYENPRLGDDINSPFSLSSISKCLGNSDFSKKRTFIETLEKNVPSAAASFRSTADGSQFLFSTPKTVSNSKKISVSSQFINEVPTDSSGLDNTPDPEVIMDSHNVSKKNHFSLLNIKNNKISQGVIKKVKKKRASKKNGERGFWDGNSVDSDDETTMSLQTNNYFTNWSLSAHRDIPYIASGYLQLFFNIFLVGVLLYFVIAFVRTIQRDVDQKVDEYSAEILQEMSLCSKEYTENRCSPDHRVPAMERACTAWERCMNRDPTVVGRAKVSAETFAEIINSFIEPISYKTMIFCILIIFGSVFVSNFAFGFFRAKSINHPHPYMAAAAPYFTDNMYNYKQYRKQLGNNLRNSRRMIYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M7P7V0</accession>
    <name>M7P7V0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873667.1">
        <property type="nucleotide sequence ID" value="XM_007875476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P7V0"/>
    <dbReference type="STRING" id="1069680.M7P7V0"/>
    <dbReference type="GeneID" id="19895397"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01703"/>
    <dbReference type="HOGENOM" id="CLU_361346_0_0_1"/>
    <dbReference type="OrthoDB" id="5356584at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="774" mass="88814" checksum="EBC7CE6B27924F94" modified="2013-05-29" version="1">MIQNIQDILEILSIHGKTVPDSEWATFFLYTKIMSRPGRRIPLLYLSQDVTYLPQSTRVCVLNSDGTASEETAMTTMLGIPVFDSYEGMSSESSPFQLLDRHKQVERNVESKYERSSPSGLSVMARSSPTFYGRTGLSSLPIQEVIDNEDRADFSRPYSGSSFSSHNLTLHKSRCESFQKTLLNTELPLKKNQKTQPSTLSPKNKSGMDDFLRNFCLLSSEKKENKKELDEQKKRTIDTNSPLENIYRTPKTRKNFRKKNNSAGKPTLDIFSNEPDFSAENSDRSLKTNDTDELTTNYAEYVPEIATIDLEDTILYVYFPTNQIKEILIEIEFISIISEATNLGADGRCYCLNLQCLPRCQNLANIRFDLQKIDNKNIHLPNTHIATENLEEGIDKSIIDVIDLTDESLEKRSWQCFWQVHLDASVYNYPGTLDIQTKVDIKSIGDAVVVGFSSNITFNQQDYDLSNILNMGLIQSFHIYGPPELQFISVKSMGILHWKCDKVSIKDNESNLKKVSSKQSDIYDYLIRITRKKEYGLSDLLIESEVIILEPFSISTLGLSLHVPYFKTKLETIQFIKTPLPLLFYVDSETQTDWKLARDKDNSLERFSILEYQCISDESTPLNIRIEKLLPLGMFKETVYLNSENYIENVDVDIFPLSFSQWCLLYKVSIMDTCIFDDILLHLKHDSNPSFITVNGKRLFSGVYSKFDGDIYILAEDWIYKDSRFKFEIGWIKDTSKSSVNKINLPIFPDNGIKKITINVDSDFGKYLKVLFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7P7W2</accession>
    <name>M7P7W2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CST complex subunit Stn1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01718</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873682.1">
        <property type="nucleotide sequence ID" value="XM_007875491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P7W2"/>
    <dbReference type="STRING" id="1069680.M7P7W2"/>
    <dbReference type="GeneID" id="19895412"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01718"/>
    <dbReference type="eggNOG" id="ENOG502RY83">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_727852_0_0_1"/>
    <dbReference type="OMA" id="EYREFTI"/>
    <dbReference type="OrthoDB" id="77828at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03524">
        <property type="entry name" value="RPA2_OBF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018856">
        <property type="entry name" value="Stn1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10451">
        <property type="entry name" value="Stn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="CST complex subunit Stn1 N-terminal" evidence="4">
        <location>
            <begin position="9"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="380" mass="44285" checksum="9D21364FBD537241" modified="2013-05-29" version="1">MFCEGNSEFYPPILFQYSPVYHTWVKLFVKDVYTLKVVEGFEDSPALFWLNHPIRWVHLFGVVVGLEKREKGDFVSLDDSSGRIIELILKERHHRHLIPAFPEENGLLDIGMRIKVRGTLSRLHGSRRISVIKLDVIHDPNIEILGWEERIRLKQEVLSKVWIIDSDLKTATIKAYLKMYNRSITQGVSKYSDYSFKILKSGEHTMQNLKRLVLNQLKENEYREFTISILRTDTEIEFAANCLATKIRIEMGELENTIVWSQSTEVCRLLMNCISELVNQGLIICVNGNQGVYVTIGEWNLSRTIRKCCRESLHKWRLAKHSSDNEKAIITTREVWQKVRRIGDEWKAVDKRLVTNIMAKVMPTLSGWRLLGKGKWILDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>M7P886</accession>
    <name>M7P886_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATPase GET3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_01840</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the arsA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873812.1">
        <property type="nucleotide sequence ID" value="XM_007875621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P886"/>
    <dbReference type="STRING" id="1069680.M7P886"/>
    <dbReference type="GeneID" id="19895534"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01840"/>
    <dbReference type="eggNOG" id="KOG2825">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040761_0_0_1"/>
    <dbReference type="OMA" id="MDAPYEF"/>
    <dbReference type="OrthoDB" id="1770at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000235">
        <property type="entry name" value="ATPase ASNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03112">
        <property type="entry name" value="Asna1_Get3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027542">
        <property type="entry name" value="ATPase_ArsA/GET3_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="9">
        <location>
            <begin position="22"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="29"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR10090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="326" mass="36645" checksum="594C4B91049B8764" modified="2013-05-29" version="1">MSLLEEPLPPTLQNILDQRSLKWIFVGGKGGVGKTTTSCSLAIQLSRVRESVLLISTDPAHNLSDAFGQKFGKDACKVNGFHNLSAMEIDPSSSIQEMIEQSELQPNNPISGMMQDLAFSIPGVDEAMGFAEIMKQVKSMEYSVCVFDTAPTGHTLRFLSFPTVLEKALTKISGLGSRFGPMFNQMSSIMGLNANQDEMFKKLDQMRTTIVEVNNQFRDSELTTFVSVCISEFLSLYEMERMIQELTSYEIDTHNIVVNQLLLNIEGSDCKQCLSRHKIQQKYLDQIIELYEDFHIVKLPQISTEVRGVEALKNFSEMLIKPYQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7P8C1</accession>
    <name>M7P8C1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01403</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873339.1">
        <property type="nucleotide sequence ID" value="XM_007875148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P8C1"/>
    <dbReference type="STRING" id="1069680.M7P8C1"/>
    <dbReference type="GeneID" id="19895100"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01403"/>
    <dbReference type="eggNOG" id="KOG3417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002116_1_0_1"/>
    <dbReference type="OMA" id="SATICHR"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF354">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="45"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="8">
        <location>
            <begin position="634"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="7">
        <location>
            <begin position="822"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="600"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1122" mass="127839" checksum="98F21098A57049C1" modified="2013-05-29" version="1">MTIEPLRIVKKQQNNSSPPQLPQPIGNMLQDLALNEQKVEDSAIHEPTYCCVIHSFSIEQSDASYLRMEQDQIIHVHFQHFSGWADGTLIETNTRGWFPLKYTEPYTLIAVRPVVTASNGLYTLFLASKTEEYITGVTGLISGVRELLMRTNTLTYDSLVINNNPAACHKRKLLLSGLNRLISFAKNISEESSVHPINKDISKELVFQLDKIVLWSKQLAHLIGPEKRAYNESILLPTSTLTKEFPSDVYAHHKVTSAESFIVSLEDQMDKLYNVDSNIPQLSNSSFHSQTCYNPASAFHNLITINDEFLSNLASLIGHLHLHSHASSQLLDTIKQCIYAARKLLSVIEQILTKYPNTQLYIAKEGFNSKTTSFIATAKKVITAHYSTSNDSNKGSVVDELECKQLMDSAASCVHDAGQCVTKAKFILRTTGDFNIPVFFPKQKSSVQLLPISAFSSRNSQISDENKLRRETYKPYNIFSTSQSEKPSLNILRKHQNEHLPSYPEISSRESINHENHSYISNDTEFDVRQEPDKCFRENLVLPRLLSAKSSPILSHSYSSALECNEKTALDNRLKTLQDLPSGTASSFASSERFSITSSYTEHISSPATSPEPIELDNTSREKEKNSKHILFNQEGQVIGASLYALVERMTLHDTTPDAIFSCTFYLTFRLFTTPRDLAIALVERFPTNKPINADHNWDQYYAIPIRLRVYNVFKTWIESYWHKDSDEDALDIIKDFISQCLIKYLPQVSTRLEELINKVLSKTASNNHFLNISRRLYNSSNRSLCSDLSMPSAIISKNLLTQLRTTSLNDNPDAFSITDFDPLEIARQLTLKESKLFCLILPEELIKLRASRKTDTYTTVKAMAALSTDIAGWVAESILSQNDIKKRAHVLKQWIKIGNKCLELNNYNTLMAILSALNLSTISRLKKTWNTLSTKSKNIFENLRSITDYSRNYALYRSRLKEHIPPCLPFLGLILTDITFIEEGNPSYRPFKNSTTAKHSIQLINYDKYIKIYSIISKLQHFQEPYKLEFVEALQTWIESQISRIRTKGQNNVTELWRRSLALEPKTHSQSLQQNDQIKNDTGSGIFIAEKIYRNSDAKKSYYNIKFPIDWTVNPLVRQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7P902</accession>
    <name>M7P902_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Nucleoporin NDC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_01564</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NDC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873515.1">
        <property type="nucleotide sequence ID" value="XM_007875324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P902"/>
    <dbReference type="STRING" id="1069680.M7P902"/>
    <dbReference type="GeneID" id="19895259"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01564"/>
    <dbReference type="eggNOG" id="ENOG502S1MG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_448494_0_0_1"/>
    <dbReference type="OMA" id="ILCQQHL"/>
    <dbReference type="OrthoDB" id="67850at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106166">
        <property type="term" value="F:spindle pole body-nuclear membrane anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070631">
        <property type="term" value="P:spindle pole body localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019049">
        <property type="entry name" value="Nucleoporin_prot_Ndc1/Nup"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269:SF6">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09531">
        <property type="entry name" value="Ndc1_Nup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR10305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="615" mass="72231" checksum="90CC1EDC9F432812" modified="2013-05-29" version="1">MVSIKDTFSKVSIRSEPVDYHAIASSILQRRFVQAVFLTYLISYVISIMIDNTFNIFKPLSWLYIGFRALILLFSVFPLFISKKANLHVDYHTKPSFISEFYLRLFSFKALRLTFIYLISSFFVTMINMTTKNTASFNQFIVSYGVYSPQLNEKTIYFVFHGLSLGLVVSIVHNLNDWDKMELPIFVQILPVRVKSEIVKIIIYSALVSLTFSFFSPLVYLFLRGWIRSFTLQFFRLLLYKIPKSSIPYWPFSIKLLLFSTFNSFIMLLLWNSVHSLFRIYLSHGPMSYGKLASERSPDPNGTLLTGLVAEFKPLTRIMAFEELYYILHHDIRRCEQIFNDIDRDPPMWQQIVEICLRIISDIPLTLRRVYQLPENKTSFSYINSEFTHKFYNQINDDTELKNPNSVPLLRIKDQNIFLEKQVHKRTPHIDHSKHRNNVNEFLSHSNKASKKNDKNIYKLQLKNIIIFYLKIFYKSWLGVPFRQTLRRKHQILFPNTRLQILAIFDLCQLVVRSIDQDLFGMVQREVALILECLNVTLEDIKQFIIFPQAHFSDIFCYQNNPDLTFEEPTALLKTLEFGMLNIISKFGPYLSGMHLQPSTAIKCQTLADFNLLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7P9A9</accession>
    <name>M7P9A9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial import receptor subunit TOM40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_01155</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873069.1">
        <property type="nucleotide sequence ID" value="XM_007874878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P9A9"/>
    <dbReference type="STRING" id="1069680.M7P9A9"/>
    <dbReference type="GeneID" id="19894852"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01155"/>
    <dbReference type="eggNOG" id="KOG3296">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042174_0_0_1"/>
    <dbReference type="OMA" id="TRFNYRW"/>
    <dbReference type="OrthoDB" id="19656at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07305">
        <property type="entry name" value="Porin3_Tom40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR10440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="37355" checksum="B042B118B62C5B24" modified="2013-05-29" version="1">MDEKSWYTPFLPIGEYIKSNFKMFRDTRASLGLSSPGTVEYLSKEVQQDVLLTRMMFSGARADLGKVFSCKDNCTFQITHSFFLGTQMFPPYSFGTVFGTKKFTATGNMDSDGQLSMRLNCQWTPSMASKIQMQLTPISGQSVAQFEHDYQGSDTSINVKYMNPSFLDNGLTGIIVANFLQTITPKLALGIEGVLQKPPSAAGPEDTMLSYVGRYVEKDWIATAQIATQGIYSFTYWRRLSPKVQVGTECQLVTASPDMTPLGVVKREGITAIGAKYEFMNSVFRGQIDTTGKVSCLLERRLANTLMFTFSGELDHSKSSINVGVGITLENNNSRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7P9N4</accession>
    <name>M7P9N4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.256</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_01285</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = a alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29543"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19512"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="ChEBI" id="CHEBI:132523"/>
            <dbReference type="EC" id="2.4.1.256"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:29544"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the ALG10 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.256" evidence="4 14"/>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873209.1">
        <property type="nucleotide sequence ID" value="XM_007875018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P9N4"/>
    <dbReference type="STRING" id="1069680.M7P9N4"/>
    <dbReference type="GeneID" id="19894982"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01285"/>
    <dbReference type="eggNOG" id="KOG2642">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017053_1_0_1"/>
    <dbReference type="OMA" id="VWDSKIT"/>
    <dbReference type="OrthoDB" id="4769at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106073">
        <property type="term" value="F:dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016900">
        <property type="entry name" value="Alg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989">
        <property type="entry name" value="ALPHA-1,2-GLUCOSYLTRANSFERASE ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989:SF10">
        <property type="entry name" value="DOL-P-GLC:GLC(2)MAN(9)GLCNAC(2)-PP-DOL ALPHA-1,2-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04922">
        <property type="entry name" value="DIE2_ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028810">
        <property type="entry name" value="Alpha1_2_glucosyltferase_Alg10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="387"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR028810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR10580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="465" mass="55695" checksum="A6F4BA1141E44B92" modified="2013-05-29" version="1">MVLKSLALQIETLRYQYAFAVQKHVLVPYMDEIFHVNQMQEYCKGNYLKWNDKITTPPGMYWIHLIILCAIPDIINRCDLSIFRMLNTITGSFCGLCFAKVITYFRENESTEMDEVEGIILAQFPLLYFHSFLYYTDVLSIFVVFLSLFLALRKQYKTSAIVSFFSLTIRQTNIIWVLFLIGISIFPLNRSIRSSEQELMVYDVPALYLRERVINIKDYVCFIKSLYRFLFQQYKQIIEVIWPYIIVVFLFAVFLLYNRGVVLGDKTNHTIKIHFPQLFYFSIFTAFWGSPHLLTNGIITHFFKWSLGSKWACFRTCVIIIIMELIIHYNTKEHPFLMSDNRHYTFYIWRRLIKVHPVAKYIAAPFYYASMWAVLNKLMFYHKISYILLFTIATTLVLGFVSLLEFRYFITPYLLWRFSIRTSHKLRLYAEAFLFLYINYITTNIFLYKPFIWESEPGSFQRFMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7PB04</accession>
    <name>M7PB04_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00657</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-X/MHF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872557.1">
        <property type="nucleotide sequence ID" value="XM_007874366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PB04"/>
    <dbReference type="STRING" id="1069680.M7PB04"/>
    <dbReference type="GeneID" id="19894355"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00657"/>
    <dbReference type="eggNOG" id="ENOG502S98G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113787_0_0_1"/>
    <dbReference type="OMA" id="YTKEAVC"/>
    <dbReference type="OrthoDB" id="2500381at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071821">
        <property type="term" value="C:FANCM-MHF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22921">
        <property type="entry name" value="HFD_CENP-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018552">
        <property type="entry name" value="CENP-X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28680">
        <property type="entry name" value="CENTROMERE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28680:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09415">
        <property type="entry name" value="CENP-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="10185" checksum="ED21230EA6DBA38C" modified="2013-05-29" version="1">MDQRDMDAKKTYPPQTIAKIFSLAFTDPTTKISASALTLCSEYIRIFCKEAIWRAAASKREHENKDENTQISLGVEDLERIAGQLTLDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7PC40</accession>
    <name>M7PC40_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endoribonuclease YSH1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Endoribonuclease ysh1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">mRNA 3'-end-processing protein YSH1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_00477</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872361.1">
        <property type="nucleotide sequence ID" value="XM_007874170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PC40"/>
    <dbReference type="STRING" id="1069680.M7PC40"/>
    <dbReference type="GeneID" id="19894175"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00477"/>
    <dbReference type="eggNOG" id="KOG1137">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009673_2_3_1"/>
    <dbReference type="OMA" id="CKQHITL"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031126">
        <property type="term" value="P:sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16292">
        <property type="entry name" value="CPSF3-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000001">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000001">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021718">
        <property type="entry name" value="CPSF73-100_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF11">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11718">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01098">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="12">
        <location>
            <begin position="32"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="13">
        <location>
            <begin position="254"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term" evidence="14">
        <location>
            <begin position="484"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00075008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR11460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="692" mass="78509" checksum="58B6433C6DF2CFE4" modified="2013-05-29" version="1">MSLKRTGEKDGIFMDSASIFEFTNLGAGNEVGRSCHIIQFRGKTIMLDAGVHPAYNGLSALPFYDEIDLSTVDILLISHFHVDHIASLPYVITKTNFKGRVFMTHPTKAIYKWLLTDFLRVSNTTSEEHLYEEKDLIKSFEKIEVVDYHSTIDVNGVKFTPYHAGHVLGAAMFFIEIAGIKILFTGDYSREEDRHLIPAELPPIQPDILITESTYGTASHQPVSEKESRLTNIIHSIIRRGGRVLIPVFALGRTQELMLIIDEYWHNHPELHSIPVYYACSLAKKCMTVYQTYINTMNNKIRKAFEERNPFIFRYISSLKSLDRFEDIGPCVMLASPGMLQNGVSRTLLEKWCPDPKNGLIIAGYCVEGTMAKHILNEPSEIISLTGQKIPRRMTVEEISFEAHVDYIQNSQFIDLVNANHIILVHGEQNNMGRLKSALLSKYSHRKNEVHVYNPKNCETLKLTFKGDKIARTIGHIAETPPENNRVISGIMVQKDFQINIMSSEDLKEFGGLTTSIIMQRQTLSFHANIDVLHYHLEQMFGTIEEEIDDNNNRVFKIMNIISIKCLQKNILSLEWIGNALNDTIADTVLAIILSAESNPSSIKTTSDSNNHCLHSNFDYKEKKNRIEMFLKSQFGQALVISNDIFEIHIDNHIAKINLETFNVECTYEPLRSRVSHVLGGAIATITPFSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCA0</accession>
    <name>M7PCA0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">DNA-binding protein creA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_03542</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the creA/MIG C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875635.1">
        <property type="nucleotide sequence ID" value="XM_007877444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCA0"/>
    <dbReference type="STRING" id="1069680.M7PCA0"/>
    <dbReference type="GeneID" id="19897229"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03542"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1256500_0_0_1"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000433">
        <property type="term" value="P:carbon catabolite repression of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000089">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000152">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051007">
        <property type="entry name" value="creA/MIG_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428:SF1">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR08104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="220" mass="24631" checksum="6897F9171B6563D4" modified="2013-05-29" version="1">MKTVTYKNSHGRNTSKAMSKENASRTLRPYECPFCPKAFYRLEHQTRHIRTHTGEKPHACTFPGCVKRFSRSDELTRHSRIHNNTRTKRGHVQFLYNNIGVFGIQTPVASTAGTFQPHTLQGLPVANVTSSVHVSPCSAECMHGSNNSQKVSTLYPQILPVPLDDMHVLAAAAFQQLEKRNISEVRTSKQNSSARTCLRHSCLDEMRAGSLPSLPISNEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCF7</accession>
    <name>M7PCF7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleolar protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00034</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOP16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871885.1">
        <property type="nucleotide sequence ID" value="XM_007873694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCF7"/>
    <dbReference type="STRING" id="1069680.M7PCF7"/>
    <dbReference type="GeneID" id="19893732"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00034"/>
    <dbReference type="eggNOG" id="KOG4771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078857_0_0_1"/>
    <dbReference type="OMA" id="MQQTEAD"/>
    <dbReference type="OrthoDB" id="285729at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019002">
        <property type="entry name" value="Ribosome_biogenesis_Nop16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243">
        <property type="entry name" value="HSPC111 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09420">
        <property type="entry name" value="Nop16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="194" mass="22856" checksum="1538F9CA12BD654F" modified="2013-05-29" version="1">MTNPRQHKKRKKIKLKKRKKTSNKSSSVSICLGPILSEKWKKEKTLEQNYRELGIVLKQNKEKESPRKAEESNGFFSNKKNLLKLKPNEAQILRDDQGNIIKVIYEKQYDFDDELNEIAMENTKAKTQVIEELKNKIKNNIKFNRRPSQNEINFLNRLIELYGDNVDAMAKDIKLNPMQQTAADLRRRISKLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M7PDH2</accession>
    <name>M7PDH2_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875041.1">
        <property type="nucleotide sequence ID" value="XM_007876850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PDH2"/>
    <dbReference type="GeneID" id="19896679"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02992"/>
    <dbReference type="HOGENOM" id="CLU_683565_0_0_1"/>
    <dbReference type="OrthoDB" id="5421270at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004083095" evidence="2">
        <location>
            <begin position="18"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="403" mass="45014" checksum="092073411C4C7A8C" modified="2013-05-29" version="1">MKILLYIYIFGLAHVFSKNIENIDEKSDLTDIKSKNFDSSHPYGFIEGIEDVLVNDKFYTLLKRLGAFASAEENSKDTLKPEIQTLARKNLNITKDEEFLLEELSGFLKNQLTLSACSKTLVLICPFVSSYPGITQSLKELLEEKCKDPNATCEYALEKLKQYCDDVKKNVESITDKTKCVYYKKKCSNLVACKNGLNVSCKKMSEKCILLQNATKGETDSSTKGETDSSTKGGTYNATKGEKDNATKGGTDNATKYNESQKKPYGSQIVIDKTTLDVETALYTHKKILYGTKCCKDKSRYTKCVSTNFLVTSACSPTIRKTYSIDSSSEVDEISPQTQCSVTLTLTNKLGETFMKTITQTFISGDMHDKGRDRGHGIQTEKHQKLILFYMVIGIITGLLIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7PDI5</accession>
    <name>M7PDI5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_03005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875056.1">
        <property type="nucleotide sequence ID" value="XM_007876865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PDI5"/>
    <dbReference type="STRING" id="1069680.M7PDI5"/>
    <dbReference type="GeneID" id="19896692"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03005"/>
    <dbReference type="eggNOG" id="KOG3291">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1262001_0_0_1"/>
    <dbReference type="OrthoDB" id="9972728at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="4">
        <location>
            <begin position="108"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="219" mass="25840" checksum="8D015AEB7CC0C9A1" modified="2013-05-29" version="1">MTYLLSNKNIIFIRFFNPITNKIIKFHNFNSSIIFLYKKEISTYEKIHKKKITLPIKTEAYEDLTLKESIKSKSKTKITENINQQTSNLNDRNNLFFSEKNYESQNLNEQFNKFDKLFNHTVGIIMKNGKKTKAQKQLQNALIYIKQKINADPYFVLSKAIKTVSPLMKLVFIKKGTKSIKVPVPLNEHQRHRKAIIWILEASNKQHILFSKKKNNYIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7PDK9</accession>
    <name>M7PDK9_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_03030</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB3 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875081.1">
        <property type="nucleotide sequence ID" value="XM_007876890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PDK9"/>
    <dbReference type="GeneID" id="19896717"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03030"/>
    <dbReference type="HOGENOM" id="CLU_145518_2_1_1"/>
    <dbReference type="OMA" id="MFRNIFP"/>
    <dbReference type="OrthoDB" id="521512at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012576">
        <property type="entry name" value="NDUFB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B12 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08122">
        <property type="entry name" value="NDUF_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR08549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="57" mass="6738" checksum="F972DE5232BB156F" modified="2013-05-29" version="1">MNDPWRKREAWRSQYPFTTIMKINKIFPGLGLGIGAFVIYCCVEKIFEKKSVLEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7PDM0</accession>
    <name>M7PDM0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA primase</fullName>
            <ecNumber evidence="9">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_03042</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="9"/>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875096.1">
        <property type="nucleotide sequence ID" value="XM_007876905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PDM0"/>
    <dbReference type="STRING" id="1069680.M7PDM0"/>
    <dbReference type="GeneID" id="19896729"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03042"/>
    <dbReference type="eggNOG" id="KOG2851">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028288_1_0_1"/>
    <dbReference type="OMA" id="NVTRGFN"/>
    <dbReference type="OrthoDB" id="19606at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04860">
        <property type="entry name" value="AE_Prim_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.920.10:FF:000002">
        <property type="entry name" value="DNA primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.920.10">
        <property type="entry name" value="DNA primase, PRIM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014052">
        <property type="entry name" value="DNA_primase_ssu_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00335">
        <property type="entry name" value="primase_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="DNA PRIMASE SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56747">
        <property type="entry name" value="Prim-pol domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="430" mass="50573" checksum="5535AD3690532A65" modified="2013-05-29" version="1">MKYDEIPEDTNEFSDPGVFFAFYQRIFPFKYVFQWLNRSPVPSKSFLNREIAFTLQNDAYLRYNSFPTYEAFRKEVLRLNPSRFEIGPIYNANPRDRKTLRKFMFKPLEKELVFDIDLTDYDDVRTCCSKTDICLKCWGFITASIKVIDSTLRDDFGFEYILWVYSGRRGVHAWVCDKKARELNDQKRKAIAAYLEVSRGGIGYGKKVEFKRPLHPSISRSLHILKESFRSNILISQNPWESDEGSEKLLEFITDHDLKETLREKWKSQPMRSSYNKWHDIDVVAESGVSKNLDTKALLTAKQDIILEYMYPRLDTEVSKHLNHLLKSPFCIHPGTGRICVPIDSSCFEKFNPFEVPTVTQLLNEIDAWDKEHKESLEISEKQEQIQDYEKTSLKPYIEYFKKFTSLIMKDEAINKKELDKSEGSVMLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7PDZ0</accession>
    <name>M7PDZ0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02862</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874899.1">
        <property type="nucleotide sequence ID" value="XM_007876708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PDZ0"/>
    <dbReference type="STRING" id="1069680.M7PDZ0"/>
    <dbReference type="GeneID" id="19896549"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02862"/>
    <dbReference type="eggNOG" id="KOG0724">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037236_2_0_1"/>
    <dbReference type="OMA" id="WKGTAYL"/>
    <dbReference type="OrthoDB" id="413400at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052606">
        <property type="entry name" value="DnaJ_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082780" description="J domain-containing protein" evidence="7">
        <location>
            <begin position="22"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="46"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="264" mass="31387" checksum="8EB41C37383F1905" modified="2013-05-29" version="1">MKFHIYMVFLIHSIYIFKINAQWSNIDYEIFNIVSSLEETEGKGTTFYSFLDLKKGPNSKIDEINKAYRQKALELHPDKIKDKKSYKISQERFSKLGLIANILRNDESKKRYDFFYKNGFPKWKGSGYYYSRYRPGFSFVLLILLIIFSSFQYIASKLNATRNRNRIKYYISSARYAARGRNMTYKSNSGRRKVINQKTGQTFIVEPDNSVYFINADGTKWLLDINDIPQARLTDTFIFVFLRFLWKHSIKRVYNFAKTKTYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7PE98</accession>
    <name>M7PE98_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Exoribonuclease phosphorolytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_02944</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874989.1">
        <property type="nucleotide sequence ID" value="XM_007876798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PE98"/>
    <dbReference type="STRING" id="1069680.M7PE98"/>
    <dbReference type="GeneID" id="19896631"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02944"/>
    <dbReference type="eggNOG" id="KOG1068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063514_1_2_1"/>
    <dbReference type="OMA" id="NIKEDPY"/>
    <dbReference type="OrthoDB" id="2504340at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF2">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="9">
        <location>
            <begin position="38"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="269" mass="30483" checksum="AECFA8DACB008FA1" modified="2013-05-29" version="1">MSERRKTTGTVISDVPVFFEDLNGEKRTKIERIRPLHESRKIYLKMGLITKADGSAYLEQERIKMVSAVYGPQQFKKATSFHSTARLNCEVKYASFALKQRYYHNREIIEKNMSMHLEAAISPSIQLDIFPKSIIHVYVFVLEADGESSTFAAAITCASAAIADASIECIDLVTGSAAVINKKNCLVMDPTDDDEIEKMFSIVIGYMAVRDELTELWSYGLGLNSTDECKIDYIINKCISMASDYRFVLNNAIMQKLEEQLRLNELMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>M7PEX6</accession>
    <name>M7PEX6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02792</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874825.1">
        <property type="nucleotide sequence ID" value="XM_007876634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PEX6"/>
    <dbReference type="STRING" id="1069680.M7PEX6"/>
    <dbReference type="GeneID" id="19896481"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02792"/>
    <dbReference type="eggNOG" id="KOG0964">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001042_5_0_1"/>
    <dbReference type="OMA" id="GQKTVCA"/>
    <dbReference type="OrthoDB" id="431497at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03272">
        <property type="entry name" value="ABC_SMC3_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000370">
        <property type="entry name" value="Structural maintenance of chromosomes 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000424">
        <property type="entry name" value="Structural maintenance of chromosomes 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041741">
        <property type="entry name" value="SMC3_ABC_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="10">
        <location>
            <begin position="522"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="186"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="399"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="476"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="694"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="757"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1197" mass="139161" checksum="1AD23D2C7953AD8B" modified="2013-05-29" version="1">MYIKQITIQGFKSYKDQTITEIFSPKYNVIVGKNGSGKSNFFSAIRFVLSDAYTHMGREERQALLHEGAGPSVMSAYVEIVFDNTDNRFPTGKEEVVLRRTIGLKKDEYSLDKRSVNKSDVMNLLESAGFSRSNPYYIVPQGRITALTNAKDSGRLALLKEIAGTQVYEQRRAESLKIIEETMVKKTKIDELLKYIDERLNELEQEKNELKEFQKKNRERRCLEYTIYAREQEEINKALTNIDEERIKNINLSEDKCDTFIEREHQIQEINKNISIIKQQLHLLNIEKSQAEEDKHCKIKEKAQLEFIARNLTESDDELKNSKNIHEKKLESLENEIKEKETHLQSLLLEFQEAKNNEMQTKNKLENAQNQQNLLYAKRGRNSQFKNKNERDAWLQQEISDLKESIKKRNQTKIELEQELETLKEKINDISKRTKSIREEIENRSQILNNISVEHSSARIVRDQLMDERKELWRQEAKLSLTIEHIKEELNQAEKKLINTISRDINYGLTNAKKIAERLDLTGYYGPLYELFEVDDRYKTAVEVTAGNSLFHVVVDNDVTASKIIDILNKEKGGRITCMPLNRLSPRQGNFPDAPDAIPILKKITYDTKYQKAFEQVFGKTIICPTLDIAAQYSRSHNITAITLNGDRSDKKGAFTGGFHDIRKSRLEAVKSVKKFQQTYEENNFSIVQIRKILEEMDQKVTQQLSKIQTLEAKKRQIEENYNPLRIELSATLKEEGILEQTLLKKKSLLNDVDFSINSLNSQLSSLQDEMKIEFKKTLTQSEEDTLENLNKTIDSIKNTYVNHHVKRTELEQQKIKLENELHENLYLRRDQLKTQGFINDEDIDVNMDETKQNLSHIQDIIDTITKKLNDIEFSIDHLSTELHEKNEEKALLQNKQNDEARTIEKYQKTLERNMAKRALLLQNKEECNKNIRDLGVLPEEAFEKFSTTESNAIVKRLHKVNEALKKFSHVNKKAFEQYNSFIKQRDALLARRKELDESQVSIENLILVLDQRKDEAIERNFKQVSKSFSEVFEKLVPMGKGRLIMQRRIDHAEDRNHDEYNKEEAHYKSPVENYVGVAISVSFNNKKDEQRIQQLSGGQKSLCALALIFAIQRCDPAPFYLLDEVDAALDAQYRTAVATMLHEMSDNGQFICTTFRPEMIQTGDKFYGIVFKNKVSSIQSIEKEEALAFVKSEAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7PFE4</accession>
    <name>M7PFE4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein MAK16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02519</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the MAK16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874529.1">
        <property type="nucleotide sequence ID" value="XM_007876338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PFE4"/>
    <dbReference type="STRING" id="1069680.M7PFE4"/>
    <dbReference type="GeneID" id="19896211"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02519"/>
    <dbReference type="eggNOG" id="KOG3064">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050888_0_1_1"/>
    <dbReference type="OMA" id="DKGQNFC"/>
    <dbReference type="OrthoDB" id="10251342at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.110:FF:000001">
        <property type="entry name" value="Protein MAK16 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006958">
        <property type="entry name" value="Mak16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405">
        <property type="entry name" value="MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405:SF4">
        <property type="entry name" value="PROTEIN MAK16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04874">
        <property type="entry name" value="Mak16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003352">
        <property type="entry name" value="MAK16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="6">
        <location>
            <begin position="4"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR003352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="304" mass="36491" checksum="6628AC6D138B3158" modified="2013-05-29" version="1">MDDVIWQVINQNFCSYKVKTNTQNFCKNEYNITGICNRQSCPLANSQYATIKEKKGILYLYMKTIERSHMPSKMWEKVKLSKNYIKALKQIDEKLLYWPNFLIYKNKARLTRLTQYLIKSKRLLLKKHPELIAIKPKEVRRETTRERKALQIAKLEKFIEKKLIERLKSGIYGKNPLNVSEDIWKKVLSSQKNQQENESELEYEDIEEQTEFFSDNEESDLEESYRKYKFEDNYDLTDDSDMSDSDISEKNHTSIKDSNIEKKEIEKIFQKRKHKGEQSRKNKKAKTYIEIEYEQENQLTDEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7PFK7</accession>
    <name>M7PFK7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GTP-binding protein ypt1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02573</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Preautophagosomal structure membrane</location>
            <topology evidence="9">Lipid-anchor</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874588.1">
        <property type="nucleotide sequence ID" value="XM_007876397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PFK7"/>
    <dbReference type="STRING" id="1069680.M7PFK7"/>
    <dbReference type="GeneID" id="19896265"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02573"/>
    <dbReference type="eggNOG" id="KOG0084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_10_1_1"/>
    <dbReference type="OMA" id="PDYHYLF"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01869">
        <property type="entry name" value="Rab1_Ypt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000069">
        <property type="entry name" value="Ras GTP-binding protein YPT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057289">
        <property type="entry name" value="Rab1/Ypt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="204" mass="22877" checksum="9921A9BF112CD03C" modified="2013-05-29" version="1">MNPEYDYLFKLLLIGDSGVGKSCLLLRFSDDTYTESYISTIGVDFKIRTIELEGKTVKLQIWDTAGQERFRTITSSYYRGAHGIIIVYDVTDQDTFNNVKQWLQEIDRYASESVNKLLIGNKSDMVDKKVVDPSQAKELANGLNIPFLETSAKSSTNVEQAFVTMAQEIKKRIGSDSAYAINGKSHIRITQGSNVQQNTSFGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7PFU2</accession>
    <name>M7PFU2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prefoldin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02272</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874263.1">
        <property type="nucleotide sequence ID" value="XM_007876072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PFU2"/>
    <dbReference type="STRING" id="1069680.M7PFU2"/>
    <dbReference type="GeneID" id="19895965"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02272"/>
    <dbReference type="eggNOG" id="KOG1760">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130032_0_0_1"/>
    <dbReference type="OMA" id="KFGRAIN"/>
    <dbReference type="OrthoDB" id="10250441at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071629">
        <property type="term" value="P:cytoplasm protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23165">
        <property type="entry name" value="Prefoldin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016661">
        <property type="entry name" value="PFDN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100:SF9">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016477">
        <property type="entry name" value="Prefoldin_subunit_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="43"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR016477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="129" mass="15682" checksum="313FE641180BAECB" modified="2013-05-29" version="1">MNRMLDRKDETDAEVNWDDQCKINTFSRLNQRLQYRKGYLKEKKLEKESIEDITEELELIDEERFFYKIGDIFIMLPIEEVKERLEKNQNEVDKNVDELEKEISKLDCYMEELKSDLYKKFGKAINLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7PGC9</accession>
    <name>M7PGC9_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02097</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874077.1">
        <property type="nucleotide sequence ID" value="XM_007875886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PGC9"/>
    <dbReference type="STRING" id="1069680.M7PGC9"/>
    <dbReference type="GeneID" id="19895791"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02097"/>
    <dbReference type="eggNOG" id="KOG4412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000134_18_2_1"/>
    <dbReference type="OMA" id="WAVAYNR"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904855">
        <property type="term" value="F:proteasome regulatory particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="135"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="168"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR09509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="231" mass="25538" checksum="F9F2D864BC6964AE" modified="2013-05-29" version="1">MEKNIHIACLNGNQDLINTLLFDDPSCINSRDQDQRTPLHWACVGSHTDIVFWLLERPDIDINAKDESWTALHISASLGNEAIVTKLLSLERCNVSIKNRGGQTALHYAVSKNHIKITERILKKAPFLVNEKDNQHQIALHRASAIGSVALICLLLSKGSSINALDIGGNTPLHHAFEECHPDAVIELLKQGADTSQKNNDNKTPIEVCGDIDVKKKVLINCKHEGIKLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7PHL9</accession>
    <name>M7PHL9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA replication complex GINS protein PSF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01712</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GINS3/PSF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873676.1">
        <property type="nucleotide sequence ID" value="XM_007875485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PHL9"/>
    <dbReference type="STRING" id="1069680.M7PHL9"/>
    <dbReference type="GeneID" id="19895406"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01712"/>
    <dbReference type="eggNOG" id="KOG1106">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081646_0_1_1"/>
    <dbReference type="OMA" id="IYKEGWR"/>
    <dbReference type="OrthoDB" id="10251744at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11713">
        <property type="entry name" value="GINS_A_psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21693">
        <property type="entry name" value="GINS_B_Psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010492">
        <property type="entry name" value="GINS_Psf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055221">
        <property type="entry name" value="PSF3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22466">
        <property type="entry name" value="PSF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF3 N-terminal" evidence="8">
        <location>
            <begin position="5"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="7">
        <location>
            <begin position="69"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="173" mass="20031" checksum="2BB73910A0CDC5D5" modified="2013-05-29" version="1">MFNYYDLDDILCENTKISSIFQHIVPGLGYLDGNNEPDIKEGANVDLPFWLAEMLVINNFIDIEFPSAFSAKVRNALKACPQNVDLRMFSTHYYLFGEKILNLLSDNELVNILIETFKSRICFIADHAHNPHGALEEGVEFLRNLEDSEKMFFRIGHDSTKDMRNWLEKSKIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7PI11</accession>
    <name>M7PI11_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FACT complex subunit POB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_01383</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SSRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873318.1">
        <property type="nucleotide sequence ID" value="XM_007875127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PI11"/>
    <dbReference type="STRING" id="1069680.M7PI11"/>
    <dbReference type="GeneID" id="19895080"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01383"/>
    <dbReference type="eggNOG" id="KOG0526">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017374_3_0_1"/>
    <dbReference type="OMA" id="QVVTKIF"/>
    <dbReference type="OrthoDB" id="498543at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045899">
        <property type="term" value="P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13230">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13231">
        <property type="entry name" value="PH2_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13229">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.220:FF:000003">
        <property type="entry name" value="FACT complex subunit POB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000001">
        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.220">
        <property type="entry name" value="Structure-specific recognition protein (SSRP1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048993">
        <property type="entry name" value="SSRP1-like_PH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000969">
        <property type="entry name" value="SSRP1/POB3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035417">
        <property type="entry name" value="SSRP1/POB3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024954">
        <property type="entry name" value="SSRP1_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038167">
        <property type="entry name" value="SSRP1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF1">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21103">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17292">
        <property type="entry name" value="POB3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03531">
        <property type="entry name" value="SSrecog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00887">
        <property type="entry name" value="SSRCOGNITION"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="12">
        <location>
            <begin position="361"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="469"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="484"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR10104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="531" mass="60862" checksum="1010FCF626F79EC1" modified="2013-05-29" version="1">MPEVIQYDDIYLNQGKIAGRLRLASSGLGWKESNSDELYTVPASDIRKAQWSRAARGYELKLTLRNGGFVQLDGFDDEDLDTLRKTIKKYFNITLEQREHSLKGWNWGKTEFSGSELLFNVSNKPAFEIPLSNISNTNLSGKNEVSLEFLLPRYDNDTEKLESQLVKGVAVQEDQLVEMRFYIPGTTITGNQENSESVNNANLFYETLKDKADIGQVSGESIVSFSDVLFLTPRGRYDVDMYSSFLRLRGKTYDYKIYYSSFVKLFLLPKPDDMHIVFVMGLDLPLRQGQTEYPFLVIQFMREEEMEVELNIEDSEFQEKYSEKLKKKYDQPAYEVVSQIFYGLTGKKVITPSTFRSYRGHAAVKCSMKASEGNLFCLDKSFLFIPKPSIWIPISEISYVTLFRINTSVSASRTFDLTFSLKGGAYYQFSNINREEQKLLEDFMKSKNIKIENDLNEDSQAILDALDDELSDDDNSSIPIRSNDDDESPDDDFQIESDSDVAEEYDENAESSKESDNENDNGPKLKKMKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7PIU8</accession>
    <name>M7PIU8_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01625</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873583.1">
        <property type="nucleotide sequence ID" value="XM_007875392.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7PIU8"/>
    <dbReference type="GeneID" id="19895319"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01625"/>
    <dbReference type="eggNOG" id="ENOG502S2X2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_260174_0_0_1"/>
    <dbReference type="OMA" id="MSSMIQR"/>
    <dbReference type="OrthoDB" id="68020at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042791">
        <property type="term" value="P:5S class rRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056020">
        <property type="entry name" value="DUF7599"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046488">
        <property type="entry name" value="Sfc3/Tfc3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044210">
        <property type="entry name" value="Tfc3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007309">
        <property type="entry name" value="TFIIIC_Bblock-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04182">
        <property type="entry name" value="B-block_TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20222">
        <property type="entry name" value="DUF6581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24538">
        <property type="entry name" value="DUF7599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="B-block binding subunit of TFIIIC" evidence="6">
        <location>
            <begin position="53"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7599" evidence="8">
        <location>
            <begin position="147"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor tau subunit sfc3/Tfc3 C-terminal" evidence="7">
        <location>
            <begin position="863"/>
            <end position="1258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1300" mass="150536" checksum="D8CB38B02F38001B" modified="2013-05-29" version="1">MILKIIKTKEVDLKLLKKRYNDNLRISVILEKQFLVLTGKELDEENKYVARYFDLLSIISKHKGKGINQIDLAKQLNIDSRSLPSRINPLIEKGLIIRLPIIISKAQTFLLIHSHYANDSLKRNQNNSQGSEDIDNIVDINYLRICITDLLSKAENNVMRYVDLKRLCKINNKLFRRGFSKQIRSMEQLGFLERCRVANNKGYSKCVKLIKPYNIDIVKEESQVNIDSDDDSNSSSDNDDNKEEIFFDLIKPVITISRDLTIEFLLFQEIKNSGKSGISGPDLKKRIVGDQWSRPLQLILDKLSLVPEKSLNLNNIQPKHLSYFTIYREQEFVGRINQYRYLSSLSYQTFCLENNITNRTKLNDLNVIFPIYDEFKLYSYDENPNISDRNIKNKHIKLEKTKKYSDDIIKSFEEGKSFKNFHIKNDMSQNSLHVDSIEKETEDKLVDSDFAGSKIRSKRTNSEEKTQEIFPHKRLKKISIKCPTNTPTNSSPVLNTSDTLDDSKTPRFAFIMKNHDSPTPTPISTFLHETSTDPLEKLTFQKHIDKNDFNGSLDYGINKIDVSIPKENSISNNNTANNKKSELAFSKYDSRISLAYVRRQNLILEILHKNGGILQGGKYLNDQYNLAFRSKTRSSSDHEIDRKTMEKTLESLKRTGKIHHICVAYTNAKGTNNMFWIVADAKYDIDGIEINNFKNRILKERSIKTKTYRPLPLKIENLVVDFPAKLKRKGLSFTDSSKSAESNHIQYKHASENHVSQEHELISQSASIINNQSLSSIVSETKTSFVSTFINDNKLVLQKPDTKAKTKSEPDRKLQLRKKLLNYNTADIFPFIGKHRFLSKNNLDDRFNEINDYQRICKNAPIRRKNNFTLNDDDILVRAIFLSKWAYGGNSGFIDWELIKKVLPHYSEAEIKSRFSTLRSKNYIKEIGNFFASFWESHYQNAIENEILSPISPVSNYSDILTLVEYSKTLDILENYDNIELPDTIEEITANYIIKNVNKTNDIRHNFFDASLSLNAREIILYETAFSYSDTDNFFQNQDEIKSIIKSILITPEENYDSEVAKKLLESYEEDHIESVLQELIQEKLIVRSKSELNRILPGRNYRFSDKFLLTFKTCFPDFLFSQAVEFYTQITQEFQKNNTVTLSEFINSGSMACVLDLVAHNYVTLSIENVLDVFSSHIHHYNTQNWEDYIIDFSVVAQLKDISYISLDKSIKYESSLKNYVWVDISGNILKSVYDQYLQTILSLIIQRPGINLSELACILHPAVDIQEIKIIISSLMPKIINNNEGALYVKQLYYKCII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJ39</accession>
    <name>M7PJ39_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873098.1">
        <property type="nucleotide sequence ID" value="XM_007874907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJ39"/>
    <dbReference type="STRING" id="1069680.M7PJ39"/>
    <dbReference type="GeneID" id="19894880"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01183"/>
    <dbReference type="eggNOG" id="ENOG502QVA4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_756750_0_0_1"/>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF6">
        <property type="entry name" value="MGS207 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="366" mass="42461" checksum="EC7C7EC9E9F44498" modified="2013-05-29" version="1">MGLIISIFKTVRFMPTTLPTYPDSARHTLEYLIRANHTNVAVIHESGRPNMFLQHIPVLYLLNTSSKYLLTVYDQIIPDDCPWKPSPSVVTQADWQMFFGNLSYAEAYKHYFDDELIHMNRDQLKTVQFYAQNILIPSLLEGDMYSTIHLGLSFILKSREMMSEALVSMCLNIHKSSLLDQEINTHEWKHGTYTLQDLLSKVAEKERIKKQTNHADSFTEKRSVYISHYVSKWDVQDSYKSLKEIQKTTLLLAIATSESILLPFLSFFNASQTLFVLSQNKVISESQIRISLQAILFHLLLNYISLNTPCIQSNKVDHYPSVDMNTIRNDPKLIFFNTEKLLAIYYLDKIKDNFEKKAISAIYYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJ62</accession>
    <name>M7PJ62_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01206</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873123.1">
        <property type="nucleotide sequence ID" value="XM_007874932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJ62"/>
    <dbReference type="STRING" id="1069680.M7PJ62"/>
    <dbReference type="GeneID" id="19894903"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01206"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_845006_0_0_1"/>
    <dbReference type="OrthoDB" id="426001at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14521">
        <property type="entry name" value="DSP_fungal_SDP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="120"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="217"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="329" mass="37755" checksum="B950E2A0F5DCB41A" modified="2013-05-29" version="1">MQNQLFKQETQESSNSLNFKDKTHFLKQPISSKKIRNTKNLSLKNVDQANQCVKGISTIISPLSKPYSTEQNRENKGFTSTNNHTLLNIIFANRIYPQNTQILFENDYNYKKNSNTYENKPVCIIEPNLWLFAEPETHIAKKFNVVINVAKEVKNPFLSQTSLEENCPKETENISSERRIFQKNLLPIESSILPPVIINNIEYLHVLWDHNVSTLSIDLPPLIDYITKKSIQENKKVLIHCQCGISRSASLIIAYVMKSLGLNIDSAYSYVKDKSPWIGPNMSLIYQLYDFNNFLYGKKKSSSNKKQTGPNIEISSSNNSRKTIIDKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJZ4</accession>
    <name>M7PJZ4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 242</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872814.1">
        <property type="nucleotide sequence ID" value="XM_007874623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJZ4"/>
    <dbReference type="GeneID" id="19894601"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00903"/>
    <dbReference type="HOGENOM" id="CLU_2074158_0_0_1"/>
    <dbReference type="OrthoDB" id="5346979at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="13191" checksum="A925E567431ECF3E" modified="2013-05-29" version="1">MSKNDSQNQWRYLLIASTVSLAQGLCLSYKYMKAKQGSFPANSVLFALKALGIGTLICFGTFGLGVATISKVLKVKNIEEFSYVMKDYAKKYFSSLKLSSEKADYEDIDEKLLSKKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7PKC5</accession>
    <name>M7PKC5_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872963.1">
        <property type="nucleotide sequence ID" value="XM_007874772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PKC5"/>
    <dbReference type="STRING" id="1069680.M7PKC5"/>
    <dbReference type="GeneID" id="19894748"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01050"/>
    <dbReference type="eggNOG" id="KOG3194">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035332_0_0_1"/>
    <dbReference type="OMA" id="WSQAYKF"/>
    <dbReference type="OrthoDB" id="337581at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033315">
        <property type="term" value="P:meiotic G2/MI DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003011">
        <property type="entry name" value="Cell_cycle_checkpoint_Rad1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003021">
        <property type="entry name" value="Rad1_Rec1_Rad17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02144">
        <property type="entry name" value="Rad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01245">
        <property type="entry name" value="RAD1REC1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01246">
        <property type="entry name" value="RAD1REPAIR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="301" mass="34226" checksum="520B8B8A661697C0" modified="2013-05-29" version="1">MEEPIFTAVTDNVIPIITLLKCIAFKPRCVVKISSEGLKLTVEDGFSLQAHAFLDKDMFSFYRFNSSNKDSMNNNDSSTPIFFTVSLLAMLECFNIMNNDLKEKNFVFNRKLQQQNILRVGGNCHLSYVGYGHPFVFIIQESGLITTCELTTFEKENLIDIFLQNNKLNQKIIIKSESLYDAIQELEFSSSELLTIRSSPQHPHLRLSSIGTMGSVIIDYTNERDVIETFSCSSVIENSYKFSMIQHSIHAMSSAIKASIRTDENGVLSIQFMIETGEGKYNFVDFRILSSTKAENHFHNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7PKY8</accession>
    <name>M7PKY8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Stress response protein NST1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00730</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May act as a negative regulator of salt tolerance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NST1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872631.1">
        <property type="nucleotide sequence ID" value="XM_007874440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PKY8"/>
    <dbReference type="STRING" id="1069680.M7PKY8"/>
    <dbReference type="GeneID" id="19894428"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00730"/>
    <dbReference type="eggNOG" id="ENOG502QSSK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002935_0_0_1"/>
    <dbReference type="OrthoDB" id="21629at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051195">
        <property type="entry name" value="Fungal_stress_NST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025279">
        <property type="entry name" value="NST1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31780:SF10">
        <property type="entry name" value="LD36051P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31780">
        <property type="entry name" value="STRESS RESPONSE PROTEIN NST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13945">
        <property type="entry name" value="NST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="418"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="690"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1070"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="445"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="693"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1070"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1080"/>
            <end position="1091"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU049441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1091" mass="126088" checksum="029FF3B54E072558" modified="2013-05-29" version="1">MSIMMHSLCERVEKEEIEKEGGERVSEMLQMNGIVSRNKKKKKKRTKQKKTEGEGSSIVKCESCSGGGNFLQSECKQNHDRRFLEDSEYDPASPSISFPIHREQTLGPSFSHADNHIGPLERKTLNRKKKKKKGVVNDTYHSSNVSDMMTQPTLQCRVTSRKSKDQIWNISTHEERERIKEFWLQLGEEERRGLVKIEKEAVLRKMKEQQKHSCSCSVCDRKRIAIEEELEMLYDAYYEELEQYANQQQKFSSLSLLHKNSMTGRSEDLDDSEGVLDSDGDYESILSENVDSRFDFFNFGNSLAVKGGIFTVADDLLKNDGKKFIEMMEQLAERRIQREEEAVMEIETTEFDSDDEEYDDESDDDEMNTLDEEQRIEEGRRMFQIFAARMFEQRVLTAYREKVAEERQQRLLEELEEENRLKEERELKKAKEKERKKDKKKLQKQLKDQEKARKVAERLAEENALRIEEEKRLEEAKKKKEELRLKREAEKKALEEEKRRQPQNKETEKERKRKEAEKDSQKKELKKEKDLKETKEVKDIKESKEPKEPKEPKELKELKEPKELKEPKELKEPKELKEPKELKEPKEPKDVKEIKEIKEIKENENKIRNDKKDNQKQKTIEVMASVSSSNRSPQIENQETFYGMAESMKETRSSVSSPLNSSFLSLKTEQESDNSLSSSSIIFPQSHSSFSIQNTSQKSPHMSSNLNSTLQHPPGLDTTFSQNLSSTHSTYQSLTSHPIINNVSGGIFSLSSTPSNQQYDYSLSPLRLPKVSSNMYKNESSPLSGNLNSYHSLPITPTSFSRPFHHHMEDKNPNGILGLHENRTKVLDDNTARIVPSSIAKPIKRPSPIQRPSGTTAYKDELRKTPTINELSEVMGSKALLDDDDNDSIILNHVNDTSRGFSNRSKPIYRRDSPFIETMNLNRHVSNSQESRHRNISDQVWLPSLSNSRFPNIWPSNTNRNSQYHVTQNVLRQRCKLICLRLDEQYGSKTRLFLIDQVLSLYNDLFSDTPVQSKQLLDACAISGNSQNGGGFFTCKIEKQHIMIRYDDVLDQTHCKSGLSGFPTMVYSSPNSPSTGSQSRWSINSSITGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7PL18</accession>
    <name>M7PL18_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Outer kinetochore protein DAD1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PNEG_00759</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872661.1">
        <property type="nucleotide sequence ID" value="XM_007874470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PL18"/>
    <dbReference type="GeneID" id="19894457"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00759"/>
    <dbReference type="eggNOG" id="ENOG502SBWQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142427_3_2_1"/>
    <dbReference type="OMA" id="RLWSTFY"/>
    <dbReference type="OrthoDB" id="5566853at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013958">
        <property type="entry name" value="DASH_Dad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28025">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28025:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08649">
        <property type="entry name" value="DASH_Dad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMR11164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="97" mass="11016" checksum="2AD8CA671AD9470E" modified="2013-05-29" version="1">MSSNVPINTETNGSSINSRSIFEKQRDVLIGQVAQSMEQIITNLNILNRNIESFITVGKEFESVSTLWKMFHDVLSKEHYPMPEETQETEQNGEGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7PMB1</accession>
    <name>M7PMB1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Indoleamine 2,3-dioxygenase</fullName>
            <ecNumber evidence="5">1.13.11.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00055</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Produces N-formyl-kynurenine through the oxidation of tryptophan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.52" evidence="5"/>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871909.1">
        <property type="nucleotide sequence ID" value="XM_007873718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PMB1"/>
    <dbReference type="STRING" id="1069680.M7PMB1"/>
    <dbReference type="GeneID" id="19893753"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00055"/>
    <dbReference type="eggNOG" id="ENOG502QV6W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010089_0_0_1"/>
    <dbReference type="OMA" id="SNKIMEP"/>
    <dbReference type="OrthoDB" id="540174at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF5">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR11614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="471" mass="55157" checksum="FDA3257D515038D0" modified="2013-05-29" version="1">MEIRIPRLEEYGLSEKMGFLPDKEPLARLTKKYYEPWEKIMDHYNDYILMGRFRRVIDELPILSVEYLDSLKEKQRSYLILSFMAHSYVWIEKKPSDRLPASIAKPWVQVSEILEIRPVISYAAVCLWNWRHPFPNEPIDLSNLTTLHTFSGTKDESWFYLISTFIEIEGAPCLQIILDTISAAYARDKNTYVYNMKRLSFYIEKITEIFCRIYEKCDPYIFYWKIRPYLSGWKNMADTGLPKGVIYEGCSEDYRQYSGGSNGQSALIHLLDIALGVDHRPTGILFYRTNACNTPVQKKCNFFQEMREYMPGSHRRFLEHLEKIMNIRQFSLDNSNDLDVVSAYNACVTSLKTLRDKHLQVVSRYIIIQSKIENFENKDYKKNSMNIGLAQHVNEKENLKGTGGTNLISFLKQFRDETTSCIIKSTIKPMSLLESSSNNRAIKMNLRNIFCLAEWNDNEWGCIGGLCYRFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZX18</accession>
    <name>A0A0W4ZX18_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_04271</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="KTW32918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871881.2">
        <property type="nucleotide sequence ID" value="XM_007873690.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZX18"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZX18"/>
    <dbReference type="GeneID" id="19893728"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04271"/>
    <dbReference type="eggNOG" id="KOG0934">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1493">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KAYHILD"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14831">
        <property type="entry name" value="AP1_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000007">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044733">
        <property type="entry name" value="AP1_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="10">
        <location>
            <begin position="3"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KTW32918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="159" mass="18836" checksum="DBEABEE2A4A7F953" modified="2016-03-16" version="1">MGISYIFLVSRQGKIRLVKWFISLNLKDKSRILKEVSQAVIQRRSKACNFLEYKDTKVCYRRYASLFFIIGIEQTDNELITLEIIHRYVETLDRYFGNVCELDIIFNFQKAYFILDELIMAGEMQESSKKNILKIVSQQDMYEEQEQAEESFSILSRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZX27</accession>
    <name>A0A0W4ZX27_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_04275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="KTW32922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871964.2">
        <property type="nucleotide sequence ID" value="XM_007873773.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZX27"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZX27"/>
    <dbReference type="GeneID" id="19893805"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04275"/>
    <dbReference type="eggNOG" id="KOG3449">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6259853at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013256">
        <property type="entry name" value="Chromatin_SPT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22691:SF8">
        <property type="entry name" value="PROTEIN SPT2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22691">
        <property type="entry name" value="YEAST SPT2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08243">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00784">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="267"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="343"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KTW32922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="392" mass="45192" checksum="7B48CCDC045E9C82" modified="2016-03-16" version="1">MNSRSQYNSLLAIASSNDRKQQICLEELEKTKTLREADNRIKESQNCEKERKERAQRIYECGLDKKKRNEENSLSNSLKMKNESQGIEKDSIKKRSRSISFKEFISQTSNMNPEILKMNLIAKINSKTNVNSPLSSTTNKKDESDSKFLVKSGANFLLKHETSSKPFQTHKQPVSFTKVPLVKKNDSLSNYKGSSSLSSKFSINKGKKNHFSTPIRSKNLTKSKIITEFHPNDLILLHTGPKRDSRTIEEIQNSIWRKKGKNFPFLYKDTSETNKNTPETNNSSKIPSNNCVSGNISSQNSFSDYKKAKLDSSEKNKTLDYNISSEIWKIFGKRKEDYISNNYDSDSDMETNAAQLQKEEEFSSRIGKIEDKEEERKEIERKIKKKRKFNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M1FPU1</accession>
    <name>M1FPU1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">ATP synthase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">atp6</name>
    </gene>
    <organism>
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="14"/>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="FASEB J." volume="27" first="1962" last="1972">
            <title>Sequencing and characterization of the complete mitochondrial genomes of three Pneumocystis species provide new insights into divergence between human and rodent Pneumocystis.</title>
            <authorList>
                <person name="Ma L"/>
                <person name="Huang DW"/>
                <person name="Cuomo CA"/>
                <person name="Sykes S"/>
                <person name="Fantoni G"/>
                <person name="Das B"/>
                <person name="Sherman BT"/>
                <person name="Yang J"/>
                <person name="Huber C"/>
                <person name="Xia Y"/>
                <person name="Davey E"/>
                <person name="Kutty G"/>
                <person name="Bishop L"/>
                <person name="Sassi M"/>
                <person name="Lempicki RA Kovacs.JA."/>
            </authorList>
            <dbReference type="PubMed" id="23392351"/>
            <dbReference type="DOI" id="10.1096/fj.12-224444"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase A chain family.</text>
    </comment>
    <dbReference type="EMBL" id="JX499144">
        <property type="protein sequence ID" value="AFR90424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_007475014.1">
        <property type="nucleotide sequence ID" value="NC_020332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M1FPU1"/>
    <dbReference type="STRING" id="1069680.M1FPU1"/>
    <dbReference type="GeneID" id="14657963"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00310">
        <property type="entry name" value="ATP-synt_Fo_a_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.220:FF:000003">
        <property type="entry name" value="ATP synthase subunit a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="entry name" value="ATP synthase, F0 complex, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01393">
        <property type="entry name" value="ATP_synth_a_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023011">
        <property type="entry name" value="ATP_synth_F0_asu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045083">
        <property type="entry name" value="ATP_synth_F0_asu_bact/mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004482">
        <property type="entry name" value="PRK05815.2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11410">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11410:SF0">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="F1F0 ATP synthase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00449">
        <property type="entry name" value="ATPASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0138">CF(0)</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFR90424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="255" mass="28859" checksum="1E1F03677027DF47" modified="2013-05-01" version="1">MLTTVFQSPLEQFEIYTIFSILLPFLGYREISITNIGIYFSIIVLILLLWNILTFSNTKIIGNGWKGSQESLYMTVLNTIENQIGSKGYRYFPLIYSIFIFILLSNFIGMIPYSFAVTSHLIFTVSLSMTLLLGTTIIGLQRHGWNFFSFFIPSGVPIILIPFLTIIEFILYISRGFSLGIRLGANVLAGHMLMKIIAGFIYQMMISGVLFFILGFIPLLLLIAISGLELAISFIQAYVFIVLTSSYIKDSIYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NIC0</accession>
    <name>M7NIC0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_03146</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875206.1">
        <property type="nucleotide sequence ID" value="XM_007877015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NIC0"/>
    <dbReference type="STRING" id="1069680.M7NIC0"/>
    <dbReference type="GeneID" id="19896833"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03146"/>
    <dbReference type="eggNOG" id="KOG0490">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_767511_0_0_1"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="156"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="158"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="361" mass="41630" checksum="33A20BE584DB60C5" modified="2013-05-29" version="1">MRTIGNEWLAIGCILYISEILNTQVYLSAYHVILNTLEIKVEHSIFEPLKEERLVFVVGFPVLQTKKNRSLTMRSPLNISKKDFSFISEQMGGSSKDGVLKTFTLDDRKLFETEKTDDFSKSTVLQTPQTFQNSEQQESTLSVSAFDTPIGIREPLRQKRRRRRTTPQELAILEDEYLKDEKPNLLNRERIAAKINSIVSGEDKMGSREIQIWFQNKRQAMRRQTLHFVSSNDHAETVSGSQAIKKPCQWDMDNVRLRQHIEHKISSFKKIPSLRLCTNEGGKAQVMFNVLCDNKNTFSLYKKDDGRDSRCMSYYMGKENVPPDYEKSIKRDVGENEIEACARSLVGLAQGWARDTYDSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NID4</accession>
    <name>M7NID4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle subunit SRP14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Signal recognition particle 14 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_03163</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of a fungal signal recognition particle (SRP) complex that consists of a 7SL RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SRP14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875226.1">
        <property type="nucleotide sequence ID" value="XM_007877035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NID4"/>
    <dbReference type="STRING" id="1069680.M7NID4"/>
    <dbReference type="GeneID" id="19896850"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03163"/>
    <dbReference type="eggNOG" id="KOG1761">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094309_1_0_1"/>
    <dbReference type="OMA" id="RFNGHNK"/>
    <dbReference type="OrthoDB" id="19209at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003210">
        <property type="entry name" value="Signal_recog_particle_SRP14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12013">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02290">
        <property type="entry name" value="SRP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="116" mass="13410" checksum="DD6CE2D882AFDEFC" modified="2013-05-29" version="1">MLLSNEEYLNSLSLLFSSEKGKGTVFLTQKRYSYKDERDPSPVEGESCDISCLTYKLLFRATDGKKTKISTLVDTSFLIPFFSRYMEICKSGMRCLKKRDRKKQKAKKNKVVDSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJW4</accession>
    <name>M7NJW4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mediator complex subunit 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MED11</name>
        <name evidence="5" type="ORF">PNEG_02695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the Mediator complex subunit 11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874719.1">
        <property type="nucleotide sequence ID" value="XM_007876528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJW4"/>
    <dbReference type="GeneID" id="19896386"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02695"/>
    <dbReference type="HOGENOM" id="CLU_2097847_0_0_1"/>
    <dbReference type="OrthoDB" id="5418434at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019404">
        <property type="entry name" value="Mediator_Med11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22890">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10280">
        <property type="entry name" value="Med11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="116" mass="13628" checksum="437820B05545A5E3" modified="2013-05-29" version="1">MDKVQNRLKQLNEIEKKISSLLKEGGLAIEIIVKKSTTKEDESLLKDAFQSHVRKYMELLEDVSVQLRNQVKALEEARVPINTIPKLQDFAKEKNIEHWKKVEMFLKKLQVKQKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7NK68</accession>
    <name>M7NK68_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_02801</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874834.1">
        <property type="nucleotide sequence ID" value="XM_007876643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NK68"/>
    <dbReference type="STRING" id="1069680.M7NK68"/>
    <dbReference type="GeneID" id="19896490"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02801"/>
    <dbReference type="eggNOG" id="KOG2387">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011675_5_0_1"/>
    <dbReference type="OMA" id="EFNNAYR"/>
    <dbReference type="OrthoDB" id="1739076at2759"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000207">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000005">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003792">
        <property type="entry name" value="PRK05380.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF0">
        <property type="entry name" value="CTP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP synthase N-terminal" evidence="11">
        <location>
            <begin position="2"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="10">
        <location>
            <begin position="318"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU810713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR09028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="567" mass="63568" checksum="E433F60FD8D06FBD" modified="2013-05-29" version="1">MKYVLVSGGVISGIGKGVIASSTGLLLKTAGFKICILLFFPFDPYMNIDAGTMSPLEHGEVYVLDDGGEVDLDLGNYERYLNITLKRENNITTGKIYSQVIENERKGDYLGKTVQVVPHVTNAIQDWIERVAKVPVDETNEEPDICVIELGGTVGDIESSAFVEAMRQFQFRVGYDNFAVIHVSLVPTINGEQKTKPTQAAIRDMRGLGLYPDFIACRSVKPLEKCAIDKIGMFCHVGPDQVLVIHDVSSTYHVPLLLEQQGIIKSLSKRLKLNDIIVSKKLIEAGIQLWTQWRMLTQLYDHLFTDISVAIVGKYTDLQDSYISVVKSLEHAALKCNRKLNILWVESSDLDDEKKILNPIIYHKAWHSVCSANAILVPGGFGVRGTEGMIAAVKWARENKVPFLGVCLGFQISVIEFSRNVCNLKDAQSTELQEDAKIPVIIGMSKTNGNYGGTMCVGLKKIFFQDYCWSKIKKLYNKELINERHRHRYQVNIQYVRQLEDAGLSFVGKDESGTKMEVFELKDHPYFIGTQYHPEYLTRPLFPSPPYLGLIAASCGILNDILEKQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NKY6</accession>
    <name>M7NKY6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit</fullName>
            <ecNumber evidence="3">2.4.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GlcNAc-PI synthesis protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_02268</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.198" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874258.1">
        <property type="nucleotide sequence ID" value="XM_007876067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NKY6"/>
    <dbReference type="STRING" id="1069680.M7NKY6"/>
    <dbReference type="GeneID" id="19895961"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02268"/>
    <dbReference type="eggNOG" id="KOG1111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_19_0_1"/>
    <dbReference type="OMA" id="SHFWMSG"/>
    <dbReference type="OrthoDB" id="734129at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03796">
        <property type="entry name" value="GT4_PIG-A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000053">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000026">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039507">
        <property type="entry name" value="PIG-A/GPI3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013234">
        <property type="entry name" value="PIGA_GPI_anchor_biosynthesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08288">
        <property type="entry name" value="PIGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="PIGA GPI anchor biosynthesis" evidence="11">
        <location>
            <begin position="42"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="10">
        <location>
            <begin position="190"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR09308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="440" mass="50062" checksum="157EF1740DB169CA" modified="2013-05-29" version="1">MPYNIAMVSDFFFPQPGGIESHIYQLSQKLLDRGHKVIIITHAYNDRMGIRYSGNGVKVYYVPFFVIFRESTFPLIYSFFPLFRNIVIREEIDVIHGHASLSSFCHEAILHARTMGIRTCFTDHSLFGFADAVSIFTNKLLKFTLSDIDHVICVSHTCKENTVLRAALDPHMVSVIPNAIVAENFSPDPSKASQDTITIVVVSRLFYNKGVDLLIATIPRICSLYSDVKFIIAGSGPKAIDIEQMREKYMLQDRVEMLGSIRHEDVRDVMVRGHIYLHPSLTEAFGTVLVEAASCGLYVVCTRVGGVPEVLPPHMTIFSEPEEDDLVSATSRAIDALKERRIRTDTFHNEIKTMYSWTDVAERTERVYDCICSTDVHPLIDRLKKYYGCGMWAGKLFCFLVAIDYLLFVILCWILPDTNIDRVEPLLLKKKQKSLDKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLT9</accession>
    <name>M7NLT9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_03544</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875637.1">
        <property type="nucleotide sequence ID" value="XM_007877446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLT9"/>
    <dbReference type="STRING" id="1069680.M7NLT9"/>
    <dbReference type="GeneID" id="19897231"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03544"/>
    <dbReference type="eggNOG" id="KOG3894">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038403_0_0_1"/>
    <dbReference type="OMA" id="YRIRTHI"/>
    <dbReference type="OrthoDB" id="342981at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019529">
        <property type="entry name" value="Syntaxin-18_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959:SF0">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10496">
        <property type="entry name" value="Syntaxin-18_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="234"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR08106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="325" mass="38381" checksum="FDBBEE6BFF5BB2D6" modified="2013-05-29" version="1">MPDLTKIFFEYSNKYSISISEINKKTDIQKKCSEDPYIKEAYQIFKHISELKKFLDSIRHAYLNIESRESIDFQSFNRQHTSILSCRSLKTLSDKQREEIDVKIRTIIKKCRERILKLEDFEKNRKAMLKKTGFFTLFLQDSAKKIEELISEHRNSITWFLNKKLKDVSRIHEEQQHIKLLRQIEKNKRIVDSANIISIEANKQTTENSMIFNLNTDLSKEQVQILETENNEMLEYFESTLDQVRSVQKSLSEISKIQTELASHIEEQSFITNRLCEEALSASQLIKNGSTQLIKTKKRNRISAKLITWFLLISSSILLLLDWYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLU8</accession>
    <name>M7NLU8_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874211.1">
        <property type="nucleotide sequence ID" value="XM_007876020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLU8"/>
    <dbReference type="STRING" id="1069680.M7NLU8"/>
    <dbReference type="GeneID" id="19895920"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02227"/>
    <dbReference type="HOGENOM" id="CLU_1696260_0_0_1"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012479">
        <property type="entry name" value="SAP30BP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13464:SF0">
        <property type="entry name" value="SAP30-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13464">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR PROTEIN HCNGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07818">
        <property type="entry name" value="HCNGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="155" mass="18240" checksum="1E3477BA665077B7" modified="2013-05-29" version="1">MTQTHINEPTTSRKSFEIPDQMFSEREAIRQYTAPKFWNLPASPPGNPSPILEKKFEHFRMLKERNIHLNENLDNSTSSQNPYLLDKLINYVGIKDYYGSNLPEELQTWKELETLKMTRNEEKNTSSSEIQDKPSEKCLQRDIHFVSKEYSSKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLZ3</accession>
    <name>M7NLZ3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_03336</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875415.1">
        <property type="nucleotide sequence ID" value="XM_007877224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLZ3"/>
    <dbReference type="STRING" id="1069680.M7NLZ3"/>
    <dbReference type="GeneID" id="19897023"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03336"/>
    <dbReference type="eggNOG" id="KOG0056">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WRANMRR"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044604">
        <property type="term" value="F:ABC-type phytochelatin transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036249">
        <property type="term" value="P:cadmium ion import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098849">
        <property type="term" value="P:cellular detoxification of cadmium ion"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071996">
        <property type="term" value="P:glutathione transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036246">
        <property type="term" value="P:phytochelatin 2 import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18583">
        <property type="entry name" value="ABC_6TM_HMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000218">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF651">
        <property type="entry name" value="HEAVY METAL TOLERANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="232"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="552"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR08161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="795" mass="91795" checksum="F3DACEE8EB15FC22" modified="2013-05-29" version="1">MEINTITDTIHYTFPWLIFMLYIVSSMIPEKHNKQKSDISSLLQTISTFLILLTFIGNSMLILVYILVKQDWWIAQSSVFYTLTSIFSWGIIFINTIEIKHRISIKLNSLIIYIFQILADTILVFSILSKPFISKWEISYSIISSSRILISMFFFTLCFLIKQKKSLTNLEDEPLLEQNQIYKDDELLDIKRKGILNDKKLENTWWNYIKKFYLFFPYLWPKDVLFLQIMIFFCFILLIVSRYINILVPQQLGIVTDKLNAYVDKKENIWISIFLFMFYRFLQGNMGLLGSIRSYLWIPINQHAYQTLSEKAFEHIHTLSLDFHLSKKTGEIISALDHGSSINTFFEMIIFQVLPVIIDIFVAIIYFFINFDAYFALNVVIMAISYIYATIKITEWRTEYRRDMVNKHRDEYSIKSDSITNYETVKYFNAEPFEFNRHKNAIRTYQKAEFKVLSSLNLLNVVQNVIYTAGLLSITSLSAYKIIKNLTSVGNFVSLLTYMTQLQGPLNYFGSLYRSIQSSLVNAERMLELFSEESAVSDNPDAIDIKITQGEVIFDNVSFSYDKRKNALNALSFHAKPGTSIALVGESGSGKTTIFRCLFKFFNIDSGTITIDGQNIHNIKLNSLRKNIGIVPQDTVLFNDTIMFNIRYAKPNASDEEVFQAAQKYNTKVGERGLRLSGGEKQRIAIARTILKNPKIILLDEATSALDTHTERQVQLALKKLTEGRTTICIAHRLSTITSCDLILCMRDGHIVESGTHNELLAKVEEAGEKGLYYSMWQKQIHANKNSNNNNNDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMD9</accession>
    <name>M7NMD9_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Calcium/proton exchanger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_02014</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873994.1">
        <property type="nucleotide sequence ID" value="XM_007875803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMD9"/>
    <dbReference type="STRING" id="1069680.M7NMD9"/>
    <dbReference type="GeneID" id="19895708"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02014"/>
    <dbReference type="eggNOG" id="KOG1397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001583_0_0_1"/>
    <dbReference type="OMA" id="PQWDMIT"/>
    <dbReference type="OrthoDB" id="16982at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990816">
        <property type="term" value="C:vacuole-mitochondrion membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000014">
        <property type="entry name" value="Cation/H+ exchanger protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF10">
        <property type="entry name" value="VNX1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="526"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="592"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="624"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="690"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="952"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="990"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1013"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="domain" description="Inner membrane component" evidence="12">
        <location>
            <begin position="267"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="526"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="880"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="46"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR09833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1053" mass="119594" checksum="4821305B3ABF3080" modified="2013-05-29" version="1">MEKKDIVLSSYASKGSFRTANSQISENECNTDESPLDISNTCAENARHSNQPSFDSTSTIRCSSSNISHQQNRNTRNFTSSSTYPCRSGYNQRAVSVTSTTSSSKQVNSRNPRYKRHIVRVISHPQRGYFSAEDDENEIEADEEAFFSEFESEFRNKTLKKKGLKRDYGKNKTIIDEIDEDTIGEEYESFGKLMCDNHNDNESISHSIDSEGSFTLKERQDAINKTHPFGIRLWKPALYKKTRSVQKTAEGDIHSTPGEPIFSRDLIGNILWTVCFGWWLALIALITSFICYILIIGQPDKDYSRVLRGLSCYVFYPFGQYVELKSEEAYAEEDEGEGHSINEYTDLEIAKHNNLPIQRIIGRRRDSIDSISDTESLLGCFHRSNNAIRRKGRRRLFGRGQWSFGRIVFFLLFYSIIAPLLLLVSAFCWLIVFAMPMAKVTYLLFDHMRRHPLSIVFHSDFRQGEFSNPTILVCTYRAFGLKYYQYTVDGVNIFFINLMFIVLFTISDEYLLGSIFGHNYFITSSATIFVLSLLSIVSLSYLVGMAVASISAQSSIGMGAAINAFFGSVVEVYLYCIALNQGKARLVEGSIVGSVLAGVLLMPGLSMCAGAIRRKTQRFNAKSAGVTSTMLLFAVIGAFAPTLFYQIYGTYELKCLPCSKSKYIYNCQRCKFDQSYAPDDPFYQNSVKPFTYICALTLILSYLIGLWFTLRTHAAMIWQTPITVSALDTPKESITSRLIKTPIRESQIFKKIIPKSFLEHQFNKRLNSTFPSCDNNNICHQNIASRNHPQDSIISYMQDSYKPEDTIHNETNAFINSMGLAMDVQESMIQNQSNHEYEQTQNNKFRKNLIHSQSYIHELEGNEHENNTGHGAPSWSLKKSTLILLTSTLLYSVVAEMLVNTVDVVLQNFHIDEKFLGFTLFALVPNTTEFMNAISFATNGNIALSMEIGSAYALQVCLLQIPCLVAYSAFRNIGKQELLSYTFSLVFPRWDLICVILCVFLLAYVYSEGKSNYFKGSILILSYTVLLMGYYFTPINIQNFSTFIIQNKYIIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMF1</accession>
    <name>M7NMF1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_03136</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875194.1">
        <property type="nucleotide sequence ID" value="XM_007877003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMF1"/>
    <dbReference type="STRING" id="1069680.M7NMF1"/>
    <dbReference type="GeneID" id="19896823"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03136"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_1_1"/>
    <dbReference type="OMA" id="LNRVRCR"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF252">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="17"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="415" mass="46500" checksum="C17A8471E0EB78A5" modified="2013-05-29" version="1">MNPSNEKPIIRDRGLECWLQALKAHLLIFVSWGIVNSFGIFQTYYKSTLLKDSSLSNIAWIGTVQGFSIILVSLLIGPVYDRGYTRPLIIFGSFLIIFGMIMMSISKKYYQFFIYEALCIGIGSGCIFIPSLGIITRYFDKKLSLAAGLITSGASVGGLIFPILFEFLIHKIGFTWTIRVFALVSFILIIISIIITEVYTFSNRSPYLFNFSSLKDYTFMIFNISAFFIFTGIYFPYFYLPMYAKALGSHFSTYFISIINLTSIFGRVITGVIADYKGPLNTFILSSLALVILTYAWIGIRNIPGLFIFSVLYGLFAGAVMSLPSAIIIKLSSNLNFVGTQMSICLLFTGIGFLIGTPIDGIILKHSNRAFFWAQIFSATIMLVGVFTLFLIVYLKRNRVLIPKTSSGASFYRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMG2</accession>
    <name>M7NMG2_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trehalose-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_03243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875310.1">
        <property type="nucleotide sequence ID" value="XM_007877119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMG2"/>
    <dbReference type="STRING" id="1069680.M7NMG2"/>
    <dbReference type="GeneID" id="19896930"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03243"/>
    <dbReference type="eggNOG" id="KOG1050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002351_3_0_1"/>
    <dbReference type="OMA" id="VHPMPIE"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01627">
        <property type="entry name" value="HAD_TPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000052">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1020:FF:000002">
        <property type="entry name" value="Trehalose-6-phosphate synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF123">
        <property type="entry name" value="TREHALOSE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="853" mass="98749" checksum="812726919ABC7DE8" modified="2013-05-29" version="1">MNLHNTLFKDEDEKAFNKDEKFEENIKNVEDSSLLSDSFINNKWKNEKKENHGICSPKNLPWPLKCSERVIFACTSIPYKCFFNPQNGEWKFRPRRGGSSLFASISWLSQETGWETKLVGWTGEITVDRQEILSSSNDMDTLNNTNTVLLTSEDKERFLESFSKTYKDQIVPIWMLSDSNHKFGETIEQQSRWRKYPNTVLLPLFHYRLWNNTTDEWNEQTCWKDYVEFNKAYLDAIVKIYKPADIIIIHDYYLLLLPQLIRQKLPNAYLGFFLHEPFPSSEIFRCLPKRKEILMGMLGANMIGFQSYSFSRHFVSTCTRVLGFDSIGKGIDVNGAYVAIEVLPMGIDAQRVEKESQTPKIQKKMQFIRELYSNKKILIGRAKIYEIQGVLQGLKAFESFLKQFSKWRNQVVFIQVTSPVNDDTSKFEKQIQDLIAEINGTYGSLEFTPVHHYHQHLEKDEYFALLRSGDVGIITAIRDSINTTSLEYVICQKGNNGPLLLSEFSGTKDALQDAIQVNPWDVTDTAKKINEALCISESEKEARQLKLYNYVIMNTVQTWISSFISKLLTNLATFNYNQITPIIDTTLLTNAYHKANKRLFMFDYDGTLTPIVKDPLFAIPSQQLLQVLRALAENPKNQVWIISGRDQNFLSKWLDIIPQLGLSAEHGCYMRFPNTSNWLDLTKNMDVSWQEEVYKIFEYYTERTQGSFIEQKKCTLTWHYRRADPDYGLFQALECQNHLESLITSNYKVEVLNGKANIEVRPFSINKGEVVNKLLSLFKDEKPDFVFSAGDDKTDEDMFRVLKKREDLKTYFTVTIGASNKITTADWHIQGPSEVLSLLESLISIKSSNDSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMS4</accession>
    <name>M7NMS4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Pheromone a factor receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_03013</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875064.1">
        <property type="nucleotide sequence ID" value="XM_007876873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMS4"/>
    <dbReference type="STRING" id="1069680.M7NMS4"/>
    <dbReference type="GeneID" id="19896700"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03013"/>
    <dbReference type="eggNOG" id="ENOG502S44N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027592_4_0_1"/>
    <dbReference type="OMA" id="IPPLIWH"/>
    <dbReference type="OrthoDB" id="2874149at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004932">
        <property type="term" value="F:mating-type factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14966">
        <property type="entry name" value="7tmD_STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001499">
        <property type="entry name" value="GPCR_STE3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097:SF1">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02076">
        <property type="entry name" value="STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00899">
        <property type="entry name" value="GPCRSTE3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR08532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="46151" checksum="B6C159AC48FFDFB6" modified="2013-05-29" version="1">MGEVFYIFFCLIGFLCSIIPSIWHWKYRNVAPLCLIFWISSTNLIYFINSIIWFNGSKSTYRGDLYCDIVTKLILGSVTGELGATVAITHYLSKIMKSSYSSIQSKITRRNQAIEDILFSFTCPIIIMSLHYIVQPARYVIDGISGCMPWTDRSWLAVIIVLLWPPVFGSISAYYSVKVIISYFKKRNEFQTILKDSKSSMTLSRFIRLIGLSSLIIAIYLPLNIYLLAINIAQIIKSNIKYSWSDVHNWNSSIFYLPKSNMPFNRWLSPSNGIIVFIFFGMGNDAILMYKEIARKLYITQFFHFVQKKIFKKKTEDNKNSQDYYNSYSFEKSLNSCPPLFYNQTRDVRILENGSLNDYSSPPIYTDHDKYNLDLSIYNQYYRDNSNINNKYGPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMV3</accession>
    <name>M7NMV3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">W2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01768</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873735.1">
        <property type="nucleotide sequence ID" value="XM_007875544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMV3"/>
    <dbReference type="STRING" id="1069680.M7NMV3"/>
    <dbReference type="GeneID" id="19895462"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01768"/>
    <dbReference type="eggNOG" id="KOG2767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026663_1_0_1"/>
    <dbReference type="OMA" id="YRYKMEK"/>
    <dbReference type="OrthoDB" id="10250831at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071074">
        <property type="term" value="F:eukaryotic initiation factor eIF2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11561">
        <property type="entry name" value="W2_eIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000031">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.350:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF7">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="7">
        <location>
            <begin position="232"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="392" mass="45104" checksum="14F8AC10952DA182" modified="2013-05-29" version="1" fragment="single">MTTINIRRDVNDSFYRYKMPRLQSKIEGRGNGIKTVIPNMSEIARALSRSPLYVTKFFGFELGAQTTTNTNADRYIVNGAHDADRLQDLLDVFIQRYVLCKSCKNPETDIIILKNDKIVRDCKACGRQSDVPQNTKLASVILKNPPKNSKNKKNKIKNNTSSEHVNIEKEVEFNDDFIHAMTASEQSLSEEHKIDDYWTMDTSEAAVKARMHELEENVKANLILYDEEEDDEPDGSNPYDEFGTWVSENFSASNIEIYRKAQELKIESKHKTVAVLAQTVFDKHILSQIKNRACLFRKIIKGQEKHEKSLLGGTERFIAINHTELLPLIPKILMQYYQSDILSEEAIKKWASKISRRYVDKDTDKKIKKVAEPFLRWLEEADDSGSESEESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN44</accession>
    <name>M7NN44_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-rRNA-processing protein RIX1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_03027</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RIX1/PELP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875078.1">
        <property type="nucleotide sequence ID" value="XM_007876887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN44"/>
    <dbReference type="STRING" id="1069680.M7NN44"/>
    <dbReference type="GeneID" id="19896714"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03027"/>
    <dbReference type="eggNOG" id="ENOG502QSEW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_379518_0_0_1"/>
    <dbReference type="OMA" id="GGWEILR"/>
    <dbReference type="OrthoDB" id="20900at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012583">
        <property type="entry name" value="RIX1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105:SF1">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08167">
        <property type="entry name" value="RIX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein RIX1 N-terminal" evidence="6">
        <location>
            <begin position="23"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="730" mass="83893" checksum="3D62EE84CE0A214D" modified="2013-05-29" version="1">MSSNIVYMEGLSVTQEALLQEILAKITTNEAHILHVFSFLLDDLHYYRPICALSPEDALWNPWHTLIYTLLQGKKAEQRWIGACLVKISAYQNGESLIQYGTTWCQRLLSLISEKEKDIVVRRACLSFLYIMLFSKGKPTYVRSFVTPFLGTFLNNLITLPRKNIELTSISIQCIQEIIEVYPSICRPFISNIRCMSIRAIKEPSINGPDIQKGLFSILSRLHLCEAKESGWEKWNFEVLSCISELHIIIDHFFEDSVDGPHTCLKPSEWGLEAFPDNFYEAIELGLQRFEKCVQIIQQYLNQSTPYCVKIPCGQLFFFIFKVFSINTTSNIKLILDNKEKLVLFMKIPYFHLITIELLTVMIQILGSNILPHLSGLVFQLNSIFSKEKELIPLKISIYNVFSTLFQNVGPSFSSCKLIDMVIQEALNDLNQLLTISQPVPILNHKNEPKKNKTSNATPSNSRFQKEYPENVTKASLNLISSVISYLSPGILSSVQRSLIDKTIISIALFPSLREKLRKQIYNSLINNVLSPGNTQAIILPHVIRIFEEAGKETDIFTHQMKNFNHIKFLTLDAILHPRFPPLQRRLKEETLKEDNDKSEILQKTNEIYFKHLKYDNISNTTNIYHIQDNCNIWKSSEKEPLNITQDITSHPTFESEEKLEFSNEHIFKTFLNNDTQNSHLSENILQPLIKTTEKESNLDTIPIGIENESDNLSDTEIPIIIMEDSSSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN56</accession>
    <name>M7NN56_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873332.1">
        <property type="nucleotide sequence ID" value="XM_007875141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN56"/>
    <dbReference type="STRING" id="1069680.M7NN56"/>
    <dbReference type="GeneID" id="19895094"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01397"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_442867_0_0_1"/>
    <dbReference type="OMA" id="NDENEWQ"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019487">
        <property type="entry name" value="RAM_signalling_pathway_SOG2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10428">
        <property type="entry name" value="SOG2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="617" mass="69490" checksum="701E9DA7542FD25E" modified="2013-05-29" version="1">MFLKVLSISRNKLKVLPIYISKMSNLKILKIDHNPITFPPKEIIHFKGGEKEMLPWLNNIKSFLSSHEEYFNDHGEEQYLTSEGEKDNFFNIYQKEKKINMSSKIQHPILTNKTTSISLSSSEKGSQKSIKDTQEKEDTLFSFSTLSTRKSSNNSESKDHQNPIKKIENKINTYNPKKISHDLETINSSINNHATFKFSKNNVQKNTEAYFKRFSTLPEAKRILLKSIEVIETSKGILFSLSQVYQGIRQYIVFCTDPSIKRTINLFLYTANIHIGALTNALEEHETKDHCMEPSFVISTCCTCIEAFKQVIGAFHKHIKKITMKADIRYTRTLLLILYGATIEIRNSWMVLVSALPPTSFNVNIFSFKNHSSGNFASSHHPTFKSLSNISITNSAAPTTNTSNINQNSIPVLSNLNQVELPNTHTSSIITQYLELADLSKTDTDEHLFEKILTATTAALSVLTLLENAATRNTITESEKNHSTTTNSEITAKLKELATMSINARGVTQKLKSQLKNIRENSSLNHKRKFWEDINAFVKSIIAIAALAKFISTEFSFSKLILSGLSTVTRSTKELTILLSISSFRSTAESQTATVPLTTFSDMPQETTTPISTNPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN69</accession>
    <name>M7NN69_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01411</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873347.1">
        <property type="nucleotide sequence ID" value="XM_007875156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN69"/>
    <dbReference type="STRING" id="1069680.M7NN69"/>
    <dbReference type="GeneID" id="19895108"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01411"/>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043579_2_0_1"/>
    <dbReference type="OMA" id="ARSREHN"/>
    <dbReference type="OrthoDB" id="1507364at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000070">
        <property type="entry name" value="Endoplasmic reticulum protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015399">
        <property type="entry name" value="DUF1977_DnaJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09320">
        <property type="entry name" value="DUF1977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="119"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="51"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="410" mass="45874" checksum="3ECDC4376A80F3B3" modified="2013-05-29" version="1">MEVNKDEAERCFEIAKKKWSEGDREGAIKFAKKSCSLFSTSEVKDFIRSLERLSDNSGPQSSKVDSSGAKTGPNGSEDLFKKSSFPKTSKGSESLSGSRDFTPKQKAVVDRVRKCKHTAYYEILDIKKDANDLEIKKSYRKLALLLHPDKNGAPGADEAFKLVSKAFQVLSDPQKRMVYDQYGDDLNSRASGAGCSGFSRAGGGLFGEEIDPQDLFNMFFGGGGNFPFSGGNPFATSFGGPQIRVHHFGGPGWRTGTNRQHGQSGQGLFGISTWIQLLPFIIVILFSILSSFANFFNSAFSLFGSGMPSYSFTPSPPFIEPRYTYYHHIPYFVDPLKVSSLSQVKLSQLDKKVEVNYINALRVNCEYEMEERKRRMEEAYGFFRVDKEAYERAKNMVQVSCNRLRELGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNC0</accession>
    <name>M7NNC0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF410 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GET4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874942.1">
        <property type="nucleotide sequence ID" value="XM_007876751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNC0"/>
    <dbReference type="STRING" id="1069680.M7NNC0"/>
    <dbReference type="GeneID" id="19896589"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02902"/>
    <dbReference type="eggNOG" id="KOG3024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046061_0_2_1"/>
    <dbReference type="OMA" id="LMDMMGM"/>
    <dbReference type="OrthoDB" id="10252405at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007317">
        <property type="entry name" value="GET4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875:SF0">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04190">
        <property type="entry name" value="GET4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="36663" checksum="CBF0994638D27713" modified="2013-05-29" version="1">MSLTQDKNIIKFQKVLDDKQYYEAHQLLRTIVNRYVKACQYVSSIDLLYNASKQFFKEGQFASGSDLALYMIKIYNIMELRPNTTSKSRLLDILYLYGSSEPTRKRFINEILAWSSKWGETPVGDADLHHNIGVLLAQEGNLFEAEKHLVLGTNESVKPLLNLLCDYFCEDNLYMAPFYASRIVFPYLILHNIACAIRGYRGIVDYLVEERKVMTHALSSSVADVILFPSLPLMNFLCFLILTCQRGAVDLFHTLKTHYADILKEAPSWQPSLEKIGNLYFNIPAQHSSKSIWSDLMSQLFSNEPESPGELPEILHETLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNL1</accession>
    <name>M7NNL1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSM4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM4</name>
        <name evidence="12" type="ORF">PNEG_02624</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874643.1">
        <property type="nucleotide sequence ID" value="XM_007876452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNL1"/>
    <dbReference type="STRING" id="1069680.M7NNL1"/>
    <dbReference type="GeneID" id="19896315"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02624"/>
    <dbReference type="eggNOG" id="KOG3293">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099537_2_2_1"/>
    <dbReference type="OMA" id="RGAFGNR"/>
    <dbReference type="OrthoDB" id="747253at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01723">
        <property type="entry name" value="LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000024">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034101">
        <property type="entry name" value="Lsm4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="82"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR08837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="129" mass="14657" checksum="74579071853DD2C7" modified="2013-05-29" version="1">MLPLSLLTATQGHPMLVELKNGETYNGHMVKCDTWMNLILKEVVQTNADGDRFFRLPECYIRGSNIKYLRIPDEIINIVKMQNERNRDNRNQRGISRGGRGIISGRGRGMQNTQGRGGRSDRGRSRNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP01</accession>
    <name>M7NP01_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02761</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874793.1">
        <property type="nucleotide sequence ID" value="XM_007876602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP01"/>
    <dbReference type="STRING" id="1069680.M7NP01"/>
    <dbReference type="GeneID" id="19896452"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02761"/>
    <dbReference type="eggNOG" id="KOG4733">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_438804_0_0_1"/>
    <dbReference type="OrthoDB" id="271725at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12243">
        <property type="entry name" value="RRM1_MSSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12244">
        <property type="entry name" value="RRM2_MSSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002343">
        <property type="entry name" value="Hud_Sxl_RNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00961">
        <property type="entry name" value="HUDSXLRNA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="289"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="377"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="572"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="623" mass="68593" checksum="C9640AA056515495" modified="2013-05-29" version="1">MSTSDTTHISVPSNKESPLTSAMASLSISAANNITTLASEESIFDGLSKHINIPLTPASNEVSPVKSQELLTSHQPDTKANLLSPPSSPLLSVQDQKLPTSNSFSIKQQKSIQNSDIVSHTQLEPSSFSGHQYIHNNNILYNNKGRYIRRINLNTINKYPADHQHTYAMSSFLRNHPAQVRPSWFTAHNHHPASLYHSIPSANIISNPTINTGTFTTPGTYRYPTHVQHPSISSIYSSSSSQPPTPLSPQIAGMIASGPPVPAPVPSIFSGPAYYDTLESSLQNPNKTTNVYIRGLPPDTTDESLYILASRFGKIHSSKAILDTQSGTCKGFGFAWFEQEEEAKACIAGLMHFGYQVSFAKESFSTRLKNLADPGSTNLYLSNLPLNMHEKDLEEQFAPYKVISNRILRDSNNVSRGVGFARMSDREAADAIIENFDGKKLPGATMPLQVRYADSPSQKRLKGQTVSRRLWRAREYNVLTGRSIIDDSLGFSSLGLGIDHYGIQHSGTGITDVHNDPSNSSTFSNLQMYFPISPGITGYPSNCETHIQSYIWNINHPHASYFKHLQQKSSINSKPKSLPETSSLNSTSVPCETNSETNNEKSTVIKEKDIAYHLVDNNIQVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP37</accession>
    <name>M7NP37_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="5">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02805</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 5">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="5"/>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874838.1">
        <property type="nucleotide sequence ID" value="XM_007876647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP37"/>
    <dbReference type="STRING" id="1069680.M7NP37"/>
    <dbReference type="GeneID" id="19896494"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02805"/>
    <dbReference type="eggNOG" id="KOG0225">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029393_5_2_1"/>
    <dbReference type="OMA" id="LGYEMPC"/>
    <dbReference type="OrthoDB" id="10256198at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000013">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5 7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="6">
        <location>
            <begin position="79"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="406" mass="45712" checksum="D12533740EB771E1" modified="2013-05-29" version="1">MIKFQSKTLRTKTFFSSYLRGKRTIFTGLSSSEKIKGNSEYDELYHIKLPESVFETYNLDPLPLDITVSKKELIKMYSDMVTIRRMELASDLLYKSKKIRGFCHLYIGQEAVAVGIEQAITPEDQVITAYRCHGFAYVRGSSIKSIIAELLGRVDGVSRGKGGSMHMFSKNFYGGNGIVGAQVPVGAGIAFAMKYLNRPNTTFTLYGDGASNQGQVFEAYNMAKLWKIPVVFGCENNKYGMGTSAERSSAMTDYYKRGHYIPGIQVDGMNVLAVKHASAFSKQYSLKNGPLVMEFVTYRYGGHSMSDPGTSYRTREEIQHVRNTNDCISLLKKIMLDYNVITESEFKTIDKSIRSHVDKEVKEAEESDFPTPDPKTLFSDIYVPGSNPEFFRGRWSGEIYTSKSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP43</accession>
    <name>M7NP43_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear speckle splicing regulatory protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02809</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NSRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874843.1">
        <property type="nucleotide sequence ID" value="XM_007876652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP43"/>
    <dbReference type="STRING" id="1069680.M7NP43"/>
    <dbReference type="GeneID" id="19896498"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02809"/>
    <dbReference type="eggNOG" id="KOG2117">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042321_1_0_1"/>
    <dbReference type="OMA" id="DEYYDSM"/>
    <dbReference type="OrthoDB" id="446635at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053246">
        <property type="entry name" value="NS_splicing_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018612">
        <property type="entry name" value="NSRP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47845">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47845:SF1">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09745">
        <property type="entry name" value="NSRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear speckle splicing regulatory protein 1 N-terminal" evidence="4">
        <location>
            <begin position="60"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="142"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="282"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="345" mass="41486" checksum="AAB1B9A27CDC6EB0" modified="2013-05-29" version="1">MNIHFGLNLSKNKNISHKNLRRNVNAFVSEENEENNDKSFENSTKMVNKELSLYYINSSKNEKNEEEIDSSIYAYDEIYDEMKEAQKKRRTETDEDKEQRKPKYMDKFFELASVRERDRLRAQEKMLQIERQAEGDMYKDKEKFVTEAYKKQQEELSRLEEEENRKEALMRKKSKGIESFYLNMLNQEEEYHNQVIEAISKSHKVLKTDDVSKEKTLEEIAKELNEKGINVTMNDDGEVVDKRQLLSAGLNIVKKSTKVSQEYLKMRKNTQNPKFVSKAHEREKREKEIFLIQEQIKQMEKEREEEERRKYEELVIKSQKKRSAEEINKIKERYLKRKAESLQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPF2</accession>
    <name>M7NPF2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874489.1">
        <property type="nucleotide sequence ID" value="XM_007876298.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPF2"/>
    <dbReference type="STRING" id="1069680.M7NPF2"/>
    <dbReference type="GeneID" id="19896173"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02480"/>
    <dbReference type="eggNOG" id="KOG1243">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010392_1_0_1"/>
    <dbReference type="OMA" id="NDTSWAG"/>
    <dbReference type="OrthoDB" id="447103at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF3">
        <property type="entry name" value="N-TERMINAL KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="1">
        <location>
            <begin position="392"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="696" mass="80034" checksum="5594AB9BF4A175BC" modified="2013-05-29" version="1">MELLRSAAALISKVTSDFGFGFGEKVELPYDSFWELYDGIRKEDGLRCSIFVFNKGSVEEKWAMAQNALSKIRTLHHPYIIRYLNGKEIEGRSITIVTERVIPLNLNRNKIDKETSILGLYQISTALQFIHENALSVHGNVRISSIFVNESGEWKIFGLELFSLIKEKECILYTHGGRIPDSFKYMPPEIQCKSWGSLNETPLETAIDAYSLGCLIYEIFNGTFRASSDLTQRGKIPQTLFNTYKKLLNPKPTLRLSVSSFINYGRSDGGFFRTELIECSEFLEQFSLKDKEQRNAFLRQISDFIDKFPKLFLKFKVLPGLIRLFEFNEGGNKAFSLILKIGNLLENDYQSLISPFIAHMFLNQNKSIRLCLLENLSDYANHISNKVINDEIFPKMLSGFNDTSPLVREETVKAVLFIVSKLSEHNINNELLKYLLKTQRDQQPEIRTNTTICLGKIAKHIKPNNRQRILISAFTGSLQDSFVPARIAALMALRATYNLFDESVCCIKLIPTISPMLIDNEKSVRIQAKKTIDLYFQKVTKLISALDNTSESANSDISNIDKSKIIVDSNSSLFSKNKIEVKQKSYNNSIEKKKVSEMNVHAFKTKNTMKQVKENDLNEWNNTNSDNTTDLLTFDDVNEDKNYINNNSNEENIHQLDRLSTIDFKINNNISFEWKQNIWDNDWDSDDDDNWKLNEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPL2</accession>
    <name>M7NPL2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02813</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09041.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613296.1">
        <property type="nucleotide sequence ID" value="XM_019757747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPL2"/>
    <dbReference type="STRING" id="1069680.M7NPL2"/>
    <dbReference type="GeneID" id="19896502"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02813"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_615563_0_0_1"/>
    <dbReference type="OMA" id="MYMCFAA"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF132">
        <property type="entry name" value="POLYAMINE TRANSPORTER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09041.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="55535" checksum="FFAAF4604C371B3D" modified="2016-03-16" version="2">MEEQVICQGCIQKLIARVEKDSTTNNEKQISSEDPYKLKLDHDDPEHPFMWNSKKKFFHLIIMLIMVFTMFLSLTFYVSHVLTKPELHTHLFLLTSMFSGFALGPFIGAPLSKHFGNRKIFLIFVFIFTIFHIFFIMISNKISLIIFRFLNGLFGGIIFSSCRLSIFDIFSNGGSFSKMLLQSSVLLGIHMGPVVGLALEENGRTVWWFWTSLILSAIIFVSSILILKEASPEIILNKRIKRLRRVTGSSRFIACIEDKKPLRYVFLALLKMSWNILGKDFMLLFVIISKVIIWNTIFLILFIHPFSLTKIYKGTLLNFFLLLLFHVLGILLATICYKIYNELYIKRQKQNKIKTKLLPSVIIYPLYISSLFWMGFTTHTLFHYIIPVLSHIVMGFSETLILDSLNQYIETSYSDDPYPVNINLAFSKLIASTIIHAIIKKSLVQKITILVTIIASINVFSYIISLVLFILGSSLRSKIQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQM9</accession>
    <name>M7NQM9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BIR-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00631</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872530.1">
        <property type="nucleotide sequence ID" value="XM_007874339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQM9"/>
    <dbReference type="STRING" id="1069680.M7NQM9"/>
    <dbReference type="GeneID" id="19894329"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00631"/>
    <dbReference type="eggNOG" id="KOG1101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_402850_0_0_1"/>
    <dbReference type="OrthoDB" id="2196114at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051190">
        <property type="entry name" value="Baculoviral_IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771:SF5">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="211"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR11033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="683" mass="78592" checksum="564B7DDAB87B7C25" modified="2013-05-29" version="1">MEVYASRLASFQLSSRKKLKWPHIRPTPKDLAEAGFYYDPSSSSHDNVVCFLCKKALDGWNANDNPVKEHIEHSRQCGWAILKYIKLCDKERNFFSEKELQDAREATFGHWWPHEQKRGWFSKVKKMSNAGFYYSPTLDSNDMVSCIYCGLGLDGWEPKDDPMEEHKKRAPSCFFFHQSTTTRLKVSEFKASSDKVKQNLDVQNDDSLDGDDSILISKSKTNSSKTKRRSIVKRSSKKSKDNNVQPRLKKPLSVSHKDDYDSSHEAFLLSAIDDKLVLDKSNLIEEKNDENNSNNIDNFCSYKETCSSFSHTNSPFGNSEFPFAGKEIIKTSKLKNTRQSQQIKKENDLNKLSFDNKHKYNTNINTNATKIQKNASIIENNKQNDLSMRSNKRLTRLGVKNDIFESYDSEGSQNGCILAKTTSNKFHRKTSFVKSAKSGEKMSLRGMKLSYDNEEKLVSESENQKIKKSFLRPRKLSRVNTQTDELEDQIISTKDSDIKKKTRLNRKTNEIVNFKELKNASKLTSKLSEVIPLQSVNKGNNYEENGDSFNRNEIFNNFVVKDSFDDSLQQKSKRIFDFDILESETKKAKDISISEIFNNNTDKKTCNWIPIDVEALVFNSSSDILANSHELTVAELDMTIEEWMKSIIQKQVEKLEIECQRMISILKKEGERAKQAILSIQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQP8</accession>
    <name>M7NQP8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED17</name>
        <name evidence="9" type="ORF">PNEG_02172</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874155.1">
        <property type="nucleotide sequence ID" value="XM_007875964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQP8"/>
    <dbReference type="STRING" id="1069680.M7NQP8"/>
    <dbReference type="GeneID" id="19895865"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02172"/>
    <dbReference type="eggNOG" id="ENOG502QS9H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015164_1_0_1"/>
    <dbReference type="OMA" id="FHNIRIN"/>
    <dbReference type="OrthoDB" id="5319830at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019313">
        <property type="entry name" value="Mediator_Med17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114:SF7">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10156">
        <property type="entry name" value="Med17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="580" mass="67227" checksum="6BD18D18761BCA6D" modified="2013-05-29" version="1">MDSVDILLVPFPREYSYGYNYDYFLENIVSRIVARYGAFRKLKISSFLDMKDDLDDNDDLKQKQDFNFSDIFDLKCDVQQIKEKLINMISNAQNECSLVLDFVSLLVSSVKPVLGNSSMSTFLKERIPVGSFGCERVRGDIFSEDFVVSKGWKLQALSKVTSDLLDASVKIDKEITLEAKFWDQVNILRQNGWNLMHSRIGRDKNFVINYGIMDVSRIFGRGFAILKRSIDGDIKFDGVDMFETFKITRLRFLENNVIKGEAVWDNSSFSEFFDKNTQILSQRRDSFFEEELLEEIIREINFFDDLNAVILDNGISVEIMESKRLLLLDIVDASTKANEFNKEYDVLCEIVLLALHLFFSYYECQKLKWTDNFPFLSKIQNKKQTRILFPIVSQLSHYFILDEVSKELKSCINVILAEGWTVDYKIKKYVDMDFGISEDSIIQSIVNGPRSVIEMYLPGSSQIVIDIRTVDYKTSFEVDFHNIRINGLMTSKTVCGSILEVLECIIWSINKDFVNVLQEAVTPNWEIKNGELVNINNTMKIKIEVFIQRNEDGIWKIFLYKNGTFVNIQDKISDVLNKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>M7NR46</accession>
    <name>M7NR46_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PNEG_02171</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874153.1">
        <property type="nucleotide sequence ID" value="XM_007875962.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NR46"/>
    <dbReference type="GeneID" id="19895864"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02171"/>
    <dbReference type="eggNOG" id="KOG0890">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000178_4_0_1"/>
    <dbReference type="OMA" id="SMYIGWC"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070310">
        <property type="term" value="C:ATR-ATRIP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033315">
        <property type="term" value="P:meiotic G2/MI DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904514">
        <property type="term" value="P:positive regulation of initiation of premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00892">
        <property type="entry name" value="PIKKc_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056802">
        <property type="entry name" value="ATR-like_M-HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012993">
        <property type="entry name" value="UME"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF125">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MEC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25030">
        <property type="entry name" value="M-HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08064">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00802">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="15">
        <location>
            <begin position="1423"/>
            <end position="1999"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="14">
        <location>
            <begin position="2107"/>
            <end position="2414"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="16">
        <location>
            <begin position="2415"/>
            <end position="2447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMR09586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="2447" mass="282423" checksum="6E3B736DCA5B138F" modified="2013-05-29" version="1">MTSESDGFRIHLNKEVSYLNEDGFERVLEQALALSNEESSSHEVTEKEIMMNAELIEIIVRMGLIGRMNEMRIRRSFFISDFEEVCIEDESVRVCVLQSLRLIEKTISRIPKVLEVVVESSKDRLIKWLIWRMMLLLRYDKMDLLRRNIYEIYLLITCTSGFFAREALDTVKNFVNVLVCDMKIGSNETYDSEIVMKFDDVPGFNQLSVFDRLDIVAHVFEMMVYWIQDQRVVGMIPGIWSSIWIGCHMDTLWEFSECFLSKTLPMKYLIWVQVLFLKILGILLFHGYENPLVDDLHVCFRVTVTLVLSGFESLYSSEINNTLNITLQEALGAGLIGISRISKRFPEYLSMIVTRLIPALERFQKSPIRFMATISDFKICYLYSILMLSNMEYLFTEIFDRVNCLAKFLFQCLKDLEIRFRSGYLKERYNSIIDYIKPIWSGYIEANNDNLIIEQLYPSLDPIFYISRYMSKAFPQFFGKIDNIFEKIQRFLFDTNLNIVQYRVIFECIGLLSCGASGCLTVFRLDCNEDFSLLCNICDCPKSSAKILDSSEIVIFSELIESCLNLEWFANCGVLRIIAMKTLGRIIRHSTIDSEIRLSTSVLGNWCIQSLQSSLRRLRIESGYTLCCYYNKKKSDDPNNEITLENRRYIFDVLKGMTVNNEKIYMESVILFWAELAKISEDEELNLILILLIEYLGQGNLFIQALIFQEIHSISDAHSLTPLQLFSPYWNTVGIAIVKQMQSRPQIVQIFSTILGISLSDFLSRTESYTLPYLIISKRKDIIEQIASSLQKDVSTLCLDNMPYILATLLTQDVACVESATMLLLSLASSDFKKVDLSGLVRSEPILIAVQLLQMFSDEFYKKRARVLRALEIVSAIVCKIPLDHVYSNTFDSKDVLAQFFSRYTLGIVAQFTDLINDVKGKNSVREKLRYLVGIEELVKLAGSFITSAIPQLSACLQSALLDPFLRKASLCSWSTLVNNLNDFDLSGLLGQTFSLFLSYWNECLTAEKQLIRDLFWSLINNRKNVIEESITSIPSLKAIKELDDIEMKLSEFRKSLSFSDYLKNITQRCVDDSEIVCYQGLLELRKCLYENQLSLHSLIVKERTEQVIEYIIRALLDVCQKYREINKDIVILSAECLGAVGAVDPLRVDAKKKKKELVVLYNFENMDENIVFVSSFIQEQLVGAFRFATDTRAQGFLAYVMQELLKFCGFTASNITNTDQSSFETFKRWSYFSIGSKQTLIPLLNSKYFVNQTQLNTVLAYPIYSSAKTYKIWLQNFSLEIFKSVEGDNAKKIFSICSYIIKNQDLNITNFLLPFALLNVILTGTECLKNMVANELLDVLKDGESEKTDHVQVEKAQLACQTVFSIIDYFNIWLRRKRSFNSNCKAAVVRKANRYMIVDDDVDNDPLIKKVESLLLVIPSDLIGRASYNCGSYARAVFHWEQYIRQERNNGLDNKGLRPLYKKLQQMYINLDDPDTIEGISSKFHTFDLDQQILIHESAGRWAAAQTCYELSLDRKNPKFELLNGLLNCLKRQGHYETLLTEIDGLISCDLNFTNKLINVGAEVAWQFEKWDILEKYLSIADTKLFDIGLGKALLLLKSKKYLDYHNCIVELRTQLAMSLGSSNIDSTWQCYDILFKLHMLFELEYLYNFFKGDSNDISLFMDGIDQRLQIMAASFEYKCSVLSLRRIILDILSSSKGIDVSDEVAKIWLKIAKLARKSDYSQQSYNSILIAESKGFPLASVEHARWWWKQGEHRKAVESLENAFAAGIFDFPENCVSDMKESDKYFDKYSSMKSKAYITGKASLLLAKWKDTGGQSNARILIQKYQEVVKKHNRWEKGHYYLGRYYNRLYDEEAKRPPNMQSANFLEGEWTRLICVNYGRALHYGSKYIYQTMPRFLTLWLDFGNNVDKIFFDFGTKEFQQNLLEARHTRLKLINDCVKKYAKRLPAYLFLTCFSQLISRITHSNPSVFSILEMIIVSVISTYPKQSLWYIFSVSKSRSKIRSERGNIILQKLMTDVKNSSVNMKKLVNQTQLLVSQLIRLCNTEITSKRTIQSLSKDFRFSFSVVPIDIVVPIQSLLVITLPSSPAAVKHHIPFPDDQPCLHGFLDEVDIMNSLQKPRKITVIGSDGRYYSFLCKPKDDLRKDARLMEFNTMINRFLRIDNESRKRQLRIRTYSVIPFNEECGLIEWVSHMRPLRDIVLKAYKQKNILINYSEVRSILDMASSSSNPGVIFTEKLLSKFPSVFHEWFLETFPSPITWRTSRLNYARTLAVMSMVGYVLGLGDRHGENILFDENNGDSFHVDFNCLFEKGLTFEKPERVPFRLTHNMVDALGVIGYNGVFRKSCEVTMRILRSNQESLTSVLETFIHDPLLEWDKKKRNISSDSNINTENVEAKKVLDSIKRKLDGYMTAEVTPLSIEGQVDELILQAVNPELLALMYIGWASYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NR79</accession>
    <name>M7NR79_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIF subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TFIIF medium subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">TFIIF-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_00817</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872724.1">
        <property type="nucleotide sequence ID" value="XM_007874533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NR79"/>
    <dbReference type="STRING" id="1069680.M7NR79"/>
    <dbReference type="GeneID" id="19894515"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00817"/>
    <dbReference type="eggNOG" id="KOG2905">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047858_0_0_1"/>
    <dbReference type="OMA" id="PIADNCY"/>
    <dbReference type="OrthoDB" id="26094at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07980">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000035">
        <property type="entry name" value="General transcription factor IIF subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003196">
        <property type="entry name" value="TFIIF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040504">
        <property type="entry name" value="TFIIF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17683">
        <property type="entry name" value="TFIIF_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF beta subunit N-terminal" evidence="12">
        <location>
            <begin position="39"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="11">
        <location>
            <begin position="227"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR11228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="339" mass="39467" checksum="DAA59665877DE849" modified="2013-05-29" version="1">MNNEGVFIKKEESIKGDIDIDYEGYEDDSGDLDMSRMRSKVWLVKVPKFLLDRWELIKEDGVDLGVIRIENNKLDNIKLIIPNIEGNKDLPLEYNVFVMNRHTRNTYVFAEKDLKSVQNTSDQTFLSERYSEKYHNPCKSLQKHIALVGTIAHECNISPIINEQYRKVMQTRSRIASQPKRKIQMLNNYNALTGNFMTLGIPETNTLRFSNFIKNTKKNSQDQKASRLPRNELLDILFKCFDDYDYYSMKTLKEITKQPETYLKEVLESIAVLLKKGPYIMKWTLKTEFKNKNHMAINEIKQSNPNKSTSTLHNSYLTHEGVSNNEGTDSNDKIMQDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRT3</accession>
    <name>M7NRT3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">54S ribosomal protein L31, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873714.1">
        <property type="nucleotide sequence ID" value="XM_007875523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRT3"/>
    <dbReference type="STRING" id="1069680.M7NRT3"/>
    <dbReference type="GeneID" id="19895444"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01750"/>
    <dbReference type="eggNOG" id="ENOG502S81F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141719_0_0_1"/>
    <dbReference type="OMA" id="KYTVFDR"/>
    <dbReference type="OrthoDB" id="2332379at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016340">
        <property type="entry name" value="Ribosomal_mL60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L31, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09784">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR09992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="13268" checksum="0CDF70E8EF0A149F" modified="2013-05-29" version="1">MFGVFKPNLPAFSGLLWKIPWRLSKTRKLRHRRRLRKVDLVLSTLHTSLSKAGLSCHALERQIREITPESKMLPKNKYTVFNKKSKNFRKSIHFVPKFTRVTVMNRMFPPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRU1</accession>
    <name>M7NRU1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GAMAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872369.1">
        <property type="nucleotide sequence ID" value="XM_007874178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRU1"/>
    <dbReference type="GeneID" id="19894181"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00483"/>
    <dbReference type="HOGENOM" id="CLU_2484259_0_0_1"/>
    <dbReference type="OrthoDB" id="9985637at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10779">
        <property type="entry name" value="DYNEIN LIGHT CHAIN ROADBLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Roadblock/LAMTOR2" evidence="2">
        <location>
            <begin position="6"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR11468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="87" mass="9763" checksum="DB5646E41D4656E6" modified="2013-05-29" version="1">MFGTCEELLARILAKHQVQGILILERASDNIIHTTFNDEISTSYAKSIKSMFLSAETLTNSTKSNNTLQFIRIKTQINEFMIVPGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRV2</accession>
    <name>M7NRV2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_02007</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873987.1">
        <property type="nucleotide sequence ID" value="XM_007875796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRV2"/>
    <dbReference type="STRING" id="1069680.M7NRV2"/>
    <dbReference type="GeneID" id="19895701"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02007"/>
    <dbReference type="eggNOG" id="KOG1290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_81_12_1"/>
    <dbReference type="OMA" id="NHKGPNG"/>
    <dbReference type="OrthoDB" id="2649at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14136">
        <property type="entry name" value="STKc_SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000409">
        <property type="entry name" value="CMGC/SRPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000076">
        <property type="entry name" value="CMGC/SRPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="86"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="290"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR09826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="539" mass="61481" checksum="CF1C99A7E1D9A323" modified="2013-05-29" version="1">MHHKKSETKKHRKDVSHSFILENNSTLEYQHPYDLQTNSSVEEGKKDRKYFLKSDEKLLGEEDLEDYCKGGYHPVQIGEKYKDGRYVIIRKLGWGHFSTVWLAKDNMKNCYVALKIVRSASHYTETALDEIKLLKRINTANPSHPGAAHIVSLLDEFEHQGPNGTHICMIFEVLGENLLNLIRRYDYRGIPIPLVKQITKQVLLGLDYLHRDCGIIHTDLKPENVLICINNEEAIAQVADTSQLTQSISPNIQNPGHNPVITNSQPLINSDILSYKNNVRIHNSKEETCDEQILKKKKSNSNENNTSMSDNDDEALEKDISGISLETNIDKQSIASSSSPDNTSYINVKIADLGNACWTHHHFTDDIQTRQYRSPEVLLGAKWGASTDCWSMSCMVFELLTGDYLFDPKNGQDYTKNDDHIAQIMELLGKFPRFLASRGKYSHEIFNKRCELRHISKLNYWGLPEVLHDKYHLSWSESDLLSDFLLPMLEIIPEKRANAGGMTNHPWLKDTPGMSKKYLNIPIGSRGEGIKGWACEENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRZ3</accession>
    <name>M7NRZ3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00534</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872424.1">
        <property type="nucleotide sequence ID" value="XM_007874233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRZ3"/>
    <dbReference type="STRING" id="1069680.M7NRZ3"/>
    <dbReference type="GeneID" id="19894232"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00534"/>
    <dbReference type="eggNOG" id="KOG1474">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001499_4_2_1"/>
    <dbReference type="OMA" id="PITYEMQ"/>
    <dbReference type="OrthoDB" id="784962at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05500">
        <property type="entry name" value="Bromo_BDF1_2_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05498">
        <property type="entry name" value="Bromo_Brdt_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043509">
        <property type="entry name" value="Bromo_Brdt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51525">
        <property type="entry name" value="NET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Bromo" evidence="5">
        <location>
            <begin position="183"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="5">
        <location>
            <begin position="355"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="NET" evidence="6">
        <location>
            <begin position="510"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="72"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="280"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="620"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="96"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="620"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="636"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="655" mass="74424" checksum="F85C48C7496E3F03" modified="2013-05-29" version="1">MPEGLICAQTATVDLKILDTTGQDLSDTKWPVKELSISTTNNEENTKQASGALLGINFEKSDSQSTWQVLNSEKSISSKEKTVESQDVEETALTPPYSNNVSPQVKSDLSPSGDSSKELVQSTETQAEAVKPESLEPCQAHFGASEALSKRIHPEDTFYEKVEQVEMTKEQYKYALSMLRQLRRNKDARPFNQPVDPIKLNIPSYPTIITHPMDFGTIDKKLSSKQYETVEEFKKDVELVFTNCFTFNGEESPISIMAKNLKNIFGKQILQMPSVDYVPTPKPSKVRKKSLSSDTGLGGNSAIHRNSMVTDRPRREIHPPPPRDLPYNETKPHRRKNAAQLQFCRNVIRELQKKTHESYAFPFYRPVDPVALNIPDYYKIVKHPMDMSTIQGKLNNVYNTADEFESDIRQMFRNCYKFNPVGTPVYNMGKRLEAVFDKKWQEKPTEHHSYSSDESDTESDDVDDNEGIALLEKQLAMMSDQLNAMRNKRASLKTKNKSGKSKKGNSRKSGYRNEERLRILSFDQRSELAQKINLLTGSKLDTVLRIMKESMPELEDQTDEIELDIDSMTPRTQSRLWNFVILNQLPNTPIGPAKAKPIAPKKNRTVLSEAEQLRQIRHLERQLSRFEDKGNGKYISSNSGTEESSSETESSSAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7NS06</accession>
    <name>M7NS06_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small EDRK-rich factor-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873613.1">
        <property type="nucleotide sequence ID" value="XM_007875422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NS06"/>
    <dbReference type="STRING" id="1069680.M7NS06"/>
    <dbReference type="GeneID" id="19895346"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01652"/>
    <dbReference type="eggNOG" id="KOG4488">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165034_4_1_1"/>
    <dbReference type="OrthoDB" id="18018at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007513">
        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04419">
        <property type="entry name" value="SERF-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small EDRK-rich factor-like N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="64" mass="7582" checksum="B67F299D90CD2A0F" modified="2013-05-29" version="1">MTRGNQRENDRIRAQKKQETAKKKKKCNTNFRNALELQAEIMRQKQKLSDEKKVTQSTNNSKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NS72</accession>
    <name>M7NS72_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase S59 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_01724</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873688.1">
        <property type="nucleotide sequence ID" value="XM_007875497.1"/>
    </dbReference>
    <dbReference type="SMR" id="M7NS72"/>
    <dbReference type="STRING" id="1069680.M7NS72"/>
    <dbReference type="GeneID" id="19895418"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01724"/>
    <dbReference type="eggNOG" id="KOG0845">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002330_0_0_1"/>
    <dbReference type="OMA" id="PMGKGLN"/>
    <dbReference type="OrthoDB" id="3797628at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2360:FF:000001">
        <property type="entry name" value="Nuclear pore complex protein Nup98-Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1610.10:FF:000003">
        <property type="entry name" value="Nucleoporin SONB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="entry name" value="Peptidase S59, nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021967">
        <property type="entry name" value="Nup98_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12110">
        <property type="entry name" value="Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase S59" evidence="12">
        <location>
            <begin position="767"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="330"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="397"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="707"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="918"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="343"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="714"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="741"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="922"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR09966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1821" mass="203751" checksum="34C96EEA3C55D19F" modified="2013-05-29" version="1">MFGQNTNNTFSRFGQQNLGTQGSQQTSTGSGTLFGSGTGVFGGSGFGQGTTFGSGNSVFGQGTQLSSTSNFSFGGSKDTTGFNTQTTNEFNSQAVSTPSRGGIFGQNSTPTGFGNTYGSNTFTGNSLNSRIPTQGTSNPPYQVTQEKETSTGGMQYFQSITCMPAYQAASFEELRLQDYTQNRRFGQQQGLFGSFSSGQTTGNIFGSGNQTYTSQPFGLSSGINMFSNTQNISSPFGQTQQNQSKPFGFGTSNTFDTTKNQTTGVFSFGNSGNSTQSAFGSSSLFRTGFNNTQNEDNKTTTFGTANMGFGQNTTNTFGSGFGTNNTGTNIFGSNQQQSTSTPFGQTSTTQNTNSFTFGGNTNTTNNPSTGGMLFGNQVQQPSTSFGQSLTQNTSSFNFGTPNTTNTTTNSVGFSFGQQDNQQNKPALSFSSNLFGQNNQNQNQNKPTFSFGNNAGFGQSTVGTGLFGTNNTNTNSSTGLFGSNTTPASNTNTSFFGNQQSSGNLFGAKPVTNTGTSLFGNNPTLQSNTNAGGGLFGNTSGQSLFKNNNQQLGNSLLGNTQQQQQPLLHASIDKNPFGNNPLFQSSSISFPTNSPGPIATPLVTNLQKKKPAMLPHFKLTPGSSSSGKFQDIKGVSFSNINSPTIISATSHSLHLFDNLNDETMLNANAFSPRSNIKKLVINRKTSQTNILTGGADLGSFEKNLLKDTDCDKQNNKSSTKQSNGMVERVPDQESPTLIAAKHQNNTKTDATSNVLHDSTEEDKRESNSLFYWTSPSISKLLDYTTDELKHVSNFKVGRKGFGQISFQSPVDLTTFEALEDIPGTIIIFDEKVCTVYPDESLKPPLGCGINVPAIITLERCWPFSKEKREPITDPNHSRFQQHLDRLKRMKETEFIDYIADTGAWIFKVNHFSRWGLLEDDDSSSEKKDQDELPKSQEIKDQYTNAPFYQKTLSSNKELKSLTKQTYVEQKKGKLEQHCELSTNNESFQENMDLNKKYADLKNKFAFQHPTSKIPGSFILENSSEIMNYTIENNTEVDISRDETESCDYLSFDDTDNYSNLQTINDIVDTSSIDLKNKESELYFEDDSKGITSSKKRDNSDDESLEILSLSSKLPFLQDIKTWPDLLNLSIERFNLLHAPQTRTKKYRDPSSLQFDSPFDNFEPVEKYELQDLDRDLYDVQQTLHLPVHTSKSNSVTTIIPGKFHWGLNNILIIPLNNKNAQPKILLKKIDNQESILDNTQLALEMQLKHTNIQIDEYGCPEANPNSTLTSKLFIPFFDNYEANILQLCGILFDKIDVYSHNLQSESQKAQILRMQRKQNLSDWLKDIVATNVENDLYKSVDPSSKMFLLLTGYQIEECCLEALKSRNFFLASLIPLIGGDELIREDCKKQIADWKDSNCLPSIGKYYRAIYELMSGNTETSQGSGMKDSEEYAPDIHISEELDWKRAFGLKLWYELTDEMPIEVAVLSYQRAFNESSTVSSPEITYSKNTNNSDTQEFDILYHLLLLFSKDDYPLENIIDSLTLNFPLNFKIPWLLYIILSRTYNIRHFQDYTSFSSKKLQENKTTIRGNQLTLNFASQLESSGLWHWAIFVLQHLQYAHIRERAIREILARNIADYYNNKKNDLDTFLMQNLKIPKIWILESCALYSRYMNYYQSEEKYLLDAKLWNEAHKTLLTFIAPQAVIYSQHDVLYAFLQRFQNTSVITDWKIGGQIYLDYIELLKFNEKSKSLSFIKNNDFEITQTQKDLVLRLLQTLPIMDAKIFEQSVAIKIMSSFSASFILSNNIMVNEHSRILQMNLTEDEYFNKIKQLSLEYYRCINTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NS80</accession>
    <name>M7NS80_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873346.1">
        <property type="nucleotide sequence ID" value="XM_007875155.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NS80"/>
    <dbReference type="STRING" id="1069680.M7NS80"/>
    <dbReference type="GeneID" id="19895107"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01410"/>
    <dbReference type="eggNOG" id="ENOG502QVRZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_714015_0_0_1"/>
    <dbReference type="OMA" id="HPASLRW"/>
    <dbReference type="OrthoDB" id="6585699at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007902">
        <property type="entry name" value="Chl4/mis15/CENP-N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05238">
        <property type="entry name" value="CENP-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="374" mass="42759" checksum="C16489361584105A" modified="2013-05-29" version="1">MKAHRLSDSHLFSYSKAIYRLLFRLSKPSLLRLVFLWLDDPFCSTFKGSVQSVRDVSVYKEWVGSNSVSRRDIVERIVSVDWKTGLSAKQIAMLDMQYLFDHPTALRWTARKIGNLETDIRLTPFDVESIVTALRNALDSIFFNYIYSEKHPALPLFLIRIQIQDAFVRVLPPPRRIFYMALPFGSPFVFHTMVRDSLHDMLLQAMEISLSSKHQPVQLFHTNLTIRNIEAMMKRKGVSRHPSALGAWSVYAKNEVDTSPIDPQEKMREPVPEDVLERRKYIAGVRFGKDLDKIEDVLDRLAFRLEEACLDDDGRSGIFRPSVTLVFEGGNVLGGLKEMCEKAIANAEQIPSWLTGEDGVTEGMTYDGLLQTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSA5</accession>
    <name>M7NSA5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01759</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873723.1">
        <property type="nucleotide sequence ID" value="XM_007875532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSA5"/>
    <dbReference type="STRING" id="1069680.M7NSA5"/>
    <dbReference type="GeneID" id="19895453"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01759"/>
    <dbReference type="eggNOG" id="KOG2901">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024840_0_0_1"/>
    <dbReference type="OMA" id="YYHPQRN"/>
    <dbReference type="OrthoDB" id="5595109at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF7">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="426" mass="49175" checksum="37BED69C27062E55" modified="2013-05-29" version="1">MSRFRTGEILEKMIRTVGPISVASFMKYCLTNPTEGYYRNRYPFGVDGDFITSPEISQIFGELIGIWMIYEWILKKKPSKITWVELGPGRGTLTDDYLRTAMMFEDYFRTIESLRLIEISPVLREFQRQLLCGSNAMENIDIDVWKCLSKYGMPVYWYERFDQLPRELSTPFIAVHEFFDSMPIHKFEVIVICLNIWNIDFDFKKKTVHGWREFLVDFVSQDAFYMKDSIEKSSAPLQFRLILSKRPTYHSLTLPNISQRYSLLPIGSCIEISPESLVLVEEISKILLNNSNTAYGSALIIDYGPSDTIPIHTLRGIRSHRIVSPFEKPGEVDLSSDVDFQALKEVVLKHDELEVYGPIEQGTWLKTMGIEVRAKALIDASKNISSKKRIESSYKRLIERGGGAMGKVYKFMAIISKRKEFPAGFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSK9</accession>
    <name>M7NSK9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Chromatin modification-related protein EAF6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_00167</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EAF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872028.1">
        <property type="nucleotide sequence ID" value="XM_007873837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSK9"/>
    <dbReference type="STRING" id="1069680.M7NSK9"/>
    <dbReference type="GeneID" id="19893865"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00167"/>
    <dbReference type="eggNOG" id="KOG3856">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1741639_0_0_1"/>
    <dbReference type="OMA" id="LKAHEGM"/>
    <dbReference type="OrthoDB" id="440324at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015418">
        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13476">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN MEAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="115"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR11733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="163" mass="18722" checksum="FE6D4A3A9E6FE2BD" modified="2013-05-29" version="1">MTGIEEIKDNELEKTPLNNGYNKGEWPTMEYYEDKKKELRDLISKKQSVDRALAALEEKIYKLEGAYLEDTSQGGNIIRGFDGFLKGSNYKKRTDYTDNDRLFSFSSGTFLKFLHKNDSGDDSDTSTSQKKKKRRKLDGDSSGSSKDLPYVSKRVRISFRTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSN4</accession>
    <name>M7NSN4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872048.1">
        <property type="nucleotide sequence ID" value="XM_007873857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSN4"/>
    <dbReference type="STRING" id="1069680.M7NSN4"/>
    <dbReference type="GeneID" id="19893883"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00185"/>
    <dbReference type="eggNOG" id="ENOG502QQNH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015737_1_2_1"/>
    <dbReference type="OMA" id="FLQVHYW"/>
    <dbReference type="OrthoDB" id="5592486at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="40877" checksum="E623A5771261CDE1" modified="2013-05-29" version="1">MTSSFKSWMITFSALFSKSVPFLTFSDVNIKQTILDIWPKQGLKDLFPATKIVEKEHPDKWRFLLPLQYPYHSPQYPIVLCHGLGFFEKTPSSLPKFQLHYWGSIVESLKKLGCQVYVTKVPSTGTIAQRARELTKQLSSMVNGRRVNLVAHSMGGLDCRYLLSKRLYKDFYPVSLTTLSCPHRGSPFMDWCRDYLGLGRVFPRVSGTLKEEVFYNSCKKYENSSSISSTILSSIMFSQTMDTPAYANLTTTYLKESFNPFILDSLEVKYYSFAAVSSVPIWHPLYFPNHIVSQAEGMDNDGLVSVKSATWGKLLGILECDHWELRGRGLGAGTGFIKQNFDVDDFYCALATHLWNENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSS6</accession>
    <name>M7NSS6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YEATS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01574</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873527.1">
        <property type="nucleotide sequence ID" value="XM_007875336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSS6"/>
    <dbReference type="STRING" id="1069680.M7NSS6"/>
    <dbReference type="GeneID" id="19895269"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01574"/>
    <dbReference type="eggNOG" id="KOG3149">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078004_0_0_1"/>
    <dbReference type="OMA" id="GEFDMTI"/>
    <dbReference type="OrthoDB" id="1741717at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16905">
        <property type="entry name" value="YEATS_Taf14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016665">
        <property type="entry name" value="Sas5/TAF14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23195">
        <property type="entry name" value="YEATS DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016551">
        <property type="entry name" value="SAS5/TFIID_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YEATS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="237" mass="27408" checksum="BA00032FF1C8A7F4" modified="2013-05-29" version="1">MVEVKRTIKFITTQNIMKDVPPAGEGFPIRRWSVRLVALSEDGQELPATFIDKVTYKLHPTFQSPNRSFKKPPFRIEEQGWGEFEMDVVIFYAEKGGETTLKHDLNFQQTKYENEHILTIVNPRPALQRLLAESGPVPGYVGLEDKKKDKRKFDGTDKNKKKGKFSKPVDMDRLADGLQKLEEDDLLQVVQMVNENKTPEMYVKNDVEEGEFHLDLYTLSDNLLTMLWNFTAKRVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSW3</accession>
    <name>M7NSW3_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873413.1">
        <property type="nucleotide sequence ID" value="XM_007875222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSW3"/>
    <dbReference type="STRING" id="1069680.M7NSW3"/>
    <dbReference type="GeneID" id="19895170"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01474"/>
    <dbReference type="eggNOG" id="ENOG502T0ZM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_676388_0_0_1"/>
    <dbReference type="OrthoDB" id="5345069at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="407" mass="47014" checksum="C48478153721E8B2" modified="2013-05-29" version="1">MYTSENIQRNRFLYSPRQFSINSKSSESKGTCSLATINQDLYPWGGEKSQNYRKAVSPIFDQVRSNCIGSDKVYMTEKVSQNTFRESYVNRLRRASATVWCEHGTQLPVDVKMAKSKSFGTKKGFAIKSFVFPHTSIAPFFKPMAQHARSTNDAAPQHTMLIPRLSATETFLDEEQDNDDVYSTHVPIDKYYPSEKPFRFIHESLEPLEPLKEDLEEHLEQYMGEQMEEHLEEHMEGCMEEHIEGCMEEHMEEHMEEHIGESIGEHMGEHMGEHMGEHMEEHMEEQIEEQMEQYIDPLEPLGTDIQYETSIKNPHFRPSSIRSTTESSRYSHAAFPSSPGVSKNSIFSKHVNEFTDNTMHTSLPSHNSLYTHVAESYSSLKSLYPVPTRKLYIVNLTKQDIFSDDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTR5</accession>
    <name>M7NTR5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01212</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873130.1">
        <property type="nucleotide sequence ID" value="XM_007874939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTR5"/>
    <dbReference type="STRING" id="1069680.M7NTR5"/>
    <dbReference type="GeneID" id="19894909"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01212"/>
    <dbReference type="eggNOG" id="ENOG502RWPB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_446973_0_0_1"/>
    <dbReference type="OMA" id="ASINDNH"/>
    <dbReference type="OrthoDB" id="298939at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="258"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="611" mass="68630" checksum="B636476CC6A3B1D8" modified="2013-05-29" version="1">MYELTNRRALRSIDNHLMNNINKLQNNYIPQHNKQLQSQLSNNDVSRFVPEDNYESLYPVINSGTFVRERPPLDLLSNSRFKGPKVGIDMSLNAAVHVGGGFIRGNLQIEIESSKVQLGSIALDCLGVESVGNNKSHILFSVAKEMMEFEDSPLNQLVYTDIGQCPEDGFWPSQKCRTSIPFDLHLPLNVGPGTFECKEGQVKYYIFATLRYKLKDKIFLSRVCKNLLLFTALHPDRALVPSEHPITCIEEGPLFCGGKGSLKVEAKLHRPVWISGQLAFVEVCTTNHSTRTVRKIKLELVRQVIIYNSPPANTKEQTLAHERVPDYIKTKILSSSILYANDPEDTRAWKGVKPDTNDSVICQLLIPSAQLTVNAGRHLAVKYFINISVGTAFTSKVVVQVPILVANLLSLDIVSHNATDVAHTMAKYQDLKAPVNNISSRAFKSSCRDAGSVSHGVDCGSSEESEDILSVVLRRKLKPLDIEKINDEDSSRFVIREASINDNHHYPRRSKSLFHPKKKYSNYNGHYEHQKAVSRDSDDVRQALSHEYRAPNMDISTTAFGFSNEPSPISSARFSQKQLRSKNSRGRSNSDPNSDPTNRRTDRPETVQEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTU4</accession>
    <name>M7NTU4_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00843</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872752.1">
        <property type="nucleotide sequence ID" value="XM_007874561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTU4"/>
    <dbReference type="GeneID" id="19894541"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00843"/>
    <dbReference type="eggNOG" id="KOG3631">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1603436_0_0_1"/>
    <dbReference type="OrthoDB" id="416729at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014612">
        <property type="entry name" value="Pop7/Rpp20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12328">
        <property type="entry name" value="Rpp20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="166" mass="18804" checksum="364505A080D09B6B" modified="2013-05-29" version="1">MSLKDKLRMTLITSKRKRSSEIQISKPIKKTFVKSTIDVPIKRAVLKGPDAFIHKRSIPHPVDVSNKIFISRKTLLMNVIKKIKQKLMSFNSKSKPIILYAQSAAIERALEIALVLSLQIPLDIQIQTGTIEIVDDVLPYDMDKMITSQIRLNSTVQVIISLLDQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUG2</accession>
    <name>M7NUG2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872999.1">
        <property type="nucleotide sequence ID" value="XM_007874808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUG2"/>
    <dbReference type="STRING" id="1069680.M7NUG2"/>
    <dbReference type="GeneID" id="19894784"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01087"/>
    <dbReference type="eggNOG" id="KOG1364">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021255_2_1_1"/>
    <dbReference type="OMA" id="IFMNTYK"/>
    <dbReference type="OrthoDB" id="270602at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02958">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14348">
        <property type="entry name" value="UBA_p47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF6">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13899">
        <property type="entry name" value="Thioredoxin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="1">
        <location>
            <begin position="361"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="438" mass="50771" checksum="65878A484E5CDB54" modified="2013-05-29" version="1">MDEAICQFCSVTYASLKEAKYYLYSSCMDLEQAIALYYESKNIKEGIEMPGEQNIFYDNLVQEAIEKNTKKDIFKGSDVSKNDDVNDLVVEKRNNISESNTSESMSKYTQLYLNRIRKSVFDQSFSTAWEDDEFSAASKERSKKSRPVYLFTPPFDIIKNIDFETAKEQAKNKMLWVMVNLQDNTDFLCQKLNRDLWKDQRVKDAILKNFIFLQYISTSSDGILYQQFYPIKEYPHISIIDPRTGERVKVWDSSVIEPDSFLMELHDFLEQYSLNPSFKNPITRKLSTKKVEDMSESEQINAALIASLNEKNKISNYKRVSSKDEVIVISDDSNINHNDTQNSLSLFEKIPAVTPPEPNAMSTDITNIQFRFSDGSKKVRLFNLSDKVSRLFEYIKSELSANSKEFELVFNRIKLINELDQTLEALKLKNVSITVEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUK4</accession>
    <name>M7NUK4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872821.1">
        <property type="nucleotide sequence ID" value="XM_007874630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUK4"/>
    <dbReference type="STRING" id="1069680.M7NUK4"/>
    <dbReference type="GeneID" id="19894608"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00910"/>
    <dbReference type="eggNOG" id="ENOG502S48N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_560347_0_0_1"/>
    <dbReference type="OrthoDB" id="1939603at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039327">
        <property type="entry name" value="CON7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167:SF3">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="311"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="357"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="416"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="487" mass="54281" checksum="6ADD470FE55B505B" modified="2013-05-29" version="1">MDASTPSEEYYNDPLSGHVLHGRTGSITGSSGDQRWPSYSRTNLEHKHGPIFEHEAECMTFSGLPPLSQAFNAYPHYPRMGSNYLDTPYSPHTQNAIHLGQSHTVAVAPRGSQGPYTYNSSSNDLHGYFGHNRSNDELFPSNSHYVNHPPSTPSGSLGSTAIGTTPPLGSSLNSNSNATLSSVPSNTTYPQSNLDSRLPINGQPHRLSPAYSSNLVHPSITPLAAEPSTQHFWPNYTMHGHTVADRTTSNNGFKSSSPINVLRQPMTIPAGVHLPYKAQNKVKQIYSFVPLPGAQTQKRPRRRYDEIERIYQCGWNGCEKAYGTLNHLNAHVFMQGHGEKRTPDEFKEIRAVWRAKKKEKIKEKQAEDQLRQEEQKRHALPSPQLSQQLSSIPESQSHPPNLSHVVYAHLPQPLPNIYPYPSQQTSLSESSHQHPYPASTYHPSLLPHLNQFIAQPQSYTSNNRDYKSHADEEDRDAEGEPDPETSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUZ0</accession>
    <name>M7NUZ0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00719</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872619.1">
        <property type="nucleotide sequence ID" value="XM_007874428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUZ0"/>
    <dbReference type="STRING" id="1069680.M7NUZ0"/>
    <dbReference type="GeneID" id="19894417"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00719"/>
    <dbReference type="eggNOG" id="ENOG502QWTH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="INWRTHP"/>
    <dbReference type="OrthoDB" id="6287070at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF722">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="102"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="515" mass="60222" checksum="7CE5D454023ED390" modified="2013-05-29" version="1">MRLKKFNQIIKHKKKNALRPTFHLLEDRYSDIYDWEVSESQILEVMSELEKYGYNLDYLTIMNVLKGNYARGNVKLAVEFLIYLSEANELIVHEIEPSIELLGSENLNGVTCYLDALLFAMFAKTNCFEAMLFQEGKDPVSTKLCTFIRLWVNMLRDGRLITKDIVSQLCDVLIECGWKSASKTQQDASEVYVFITEKLNFPLLTFKVVIAHGGKFNSEEDNKYIHERLLCVPIPGDFLSYETPISLEDCLSEYFNNKIKVKRCVEQSFSAESSKKGSQKYLYNRNIIDNDKNYYEQLDEFYDNDIATLYPQRDLSLVSAWQFFQLLPFYVYKQPDNLNQHFLEKLPIVTICLKRYTWTVTGEAYCNNRRVLIPLVLDLPYFISHEEVSSNNSIEIKKYRLVLQSVVCHRNAGFTIDSGHYIAFSRDSFSKKWFLFDDLAYQKVSVFCDPSEVLNSEMPYMLFYQLESYIPNLSQEIPKIDAFKSSDDIQDFSTFSKPSKRFNETKYSEKNCLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVC4</accession>
    <name>M7NVC4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxycytidylate deaminase</fullName>
            <ecNumber evidence="7">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_00826</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="7"/>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872733.1">
        <property type="nucleotide sequence ID" value="XM_007874542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVC4"/>
    <dbReference type="STRING" id="1069680.M7NVC4"/>
    <dbReference type="GeneID" id="19894524"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00826"/>
    <dbReference type="eggNOG" id="KOG3127">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047993_0_1_1"/>
    <dbReference type="OMA" id="YFMRLAD"/>
    <dbReference type="OrthoDB" id="6710946at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000035">
        <property type="entry name" value="dCMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="10">
        <location>
            <begin position="188"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR11237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="338" mass="39036" checksum="6D8F85EB7EA858DB" modified="2013-05-29" version="1">MPFIGICGDICSGKQTIANYLVEKMNFSILKLQNKNNDSFKLSSFSPLSNNSKCLCKEEGKTFENAIQMLNYVTSHWRERFVTIDIFTEEVLNIFTKRPFFLFISVSSPIMLRWDRYKKCYKYRNSHLLTLEQFIQQSDDFFFNSERGIVHLFNKAQIKIINNYNSIPEFYKVLHRIDLINENRFRPSWDSYFMYLASLAALRSNCMKRRVGCVLVRNKRVISTGYNGTPRGFINCNQGGCKRCNEDGGSGQDLETCLCLHAEENALLEAGKERIANDSVLYCNTCPCLTCSIKITQLGVREVIFNCSYSMDNQSSKIFSQSGVILRQHIVSQEITFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVE0</accession>
    <name>M7NVE0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00704</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872603.1">
        <property type="nucleotide sequence ID" value="XM_007874412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVE0"/>
    <dbReference type="STRING" id="1069680.M7NVE0"/>
    <dbReference type="GeneID" id="19894402"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00704"/>
    <dbReference type="eggNOG" id="ENOG502QY9M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026175_1_0_1"/>
    <dbReference type="OMA" id="PENPWID"/>
    <dbReference type="OrthoDB" id="5567124at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005358524" description="Phospholipid/glycerol acyltransferase domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="3">
        <location>
            <begin position="39"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR11106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="480" mass="56514" checksum="5B6EA7D8DAABCCAB" modified="2013-05-29" version="1">MGFSWLYLIFRYLSKLLLRGFYRSITVIHHEMIDFKKPIIIFCTHTNMGNIAIVAATFPRPVRFWAKSSIFKINPIVTKVLNSLGVIPVDRETKNNRVLFEITFNAMKELETLVIYPEGTSHTSPHLLDLKDGGSWVALQYKYNIFNHKENPSRMFDKLNDVTLLPVGITYFEKSKYRSNVIVTYGTPIHIGMYKDDFLIEPKNTVKKLTKVIQERLWKITINAENWDILRISEFSRTILFGDNKNINAKDYISITQSFINIYELQRLDPSHNDISDLYNILEKELKALKLSCIEAVDIINLHTISRRWFLFQIIRTTIFLMIHILLVLPIILIHIPAYIICYLVEKMQKFDESKAQNKILIGFLVFITIDIYIFFAIRKVFAFHSLSETISLSIIIITVNYYNKIVDGFYDRWKHYKKTWNLGWVIFSPYGKSYILERLHELQKAKKKLINMIQSGQGKDIDIIREAFESIYIKHFHIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVZ0</accession>
    <name>M7NVZ0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_00492</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic/archaeal RNase P protein component 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872378.1">
        <property type="nucleotide sequence ID" value="XM_007874187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVZ0"/>
    <dbReference type="STRING" id="1069680.M7NVZ0"/>
    <dbReference type="GeneID" id="19894190"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00492"/>
    <dbReference type="eggNOG" id="KOG4394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079140_4_0_1"/>
    <dbReference type="OMA" id="DPKHLLW"/>
    <dbReference type="OrthoDB" id="128536at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR11477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="137" mass="15933" checksum="D3C2B8F07BB4A961" modified="2013-05-29" version="1">MTKKRKSSKESKIVPQQELYARISFLYQAANVYTSHSILNQNTYVDKDIQSKLALSRFYINTAKKIARKAVLKINSSIKRTLCRRCDTILLPAITSSIRIENLSKNNKEEADTMIITCNFCNTQKRYPTLKDNYRFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWE9</accession>
    <name>M7NWE9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MICOS complex subunit MIC10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00061</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Mitochondrion inner membrane</location>
            <topology evidence="2 9">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the MICOS complex subunit Mic10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871917.1">
        <property type="nucleotide sequence ID" value="XM_007873726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWE9"/>
    <dbReference type="STRING" id="1069680.M7NWE9"/>
    <dbReference type="GeneID" id="19893759"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00061"/>
    <dbReference type="eggNOG" id="KOG4604">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068905_4_0_1"/>
    <dbReference type="OMA" id="SNCRHDL"/>
    <dbReference type="OrthoDB" id="1916310at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007512">
        <property type="entry name" value="Mic10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304:SF0">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04418">
        <property type="entry name" value="DUF543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="84" mass="9248" checksum="B6EB3E8D6C4EB7ED" modified="2013-05-29" version="1">MVQTKTSYSEDIFGEKWDLCLSNAIVNAGIGLGSGIIASVCLFKRKMWPAMLGFGFGLGKAYSDCDRQFNPYSIPGFQIQKSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWI9</accession>
    <name>M7NWI9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_00095</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871952.1">
        <property type="nucleotide sequence ID" value="XM_007873761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWI9"/>
    <dbReference type="STRING" id="1069680.M7NWI9"/>
    <dbReference type="GeneID" id="19893793"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00095"/>
    <dbReference type="eggNOG" id="KOG0358">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_9_1_1"/>
    <dbReference type="OMA" id="HPAANMI"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03338">
        <property type="entry name" value="TCP1_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000010">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012717">
        <property type="entry name" value="Chap_CCT_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02342">
        <property type="entry name" value="chap_CCT_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR11657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="526" mass="57223" checksum="7661E4B117C273E0" modified="2013-05-29" version="1">MVDSKLTKQFQDKEKSNSVRLSNITAAKAVADTIRTSLGPKGMDKMIQTSKGDVILTNDGATILKHLSVVHPAAKMLVDVSFSQDIEAGDGTTTVVVITGSLLSAAEKLLAKGIHPTIIAESFQRAAAHAVNALEACSKEIDLSDRNTLIRVASTSLNSKIVSQYSVLLAPIAVDAITKVISSFSANNVDIYDIRIVKKVGGTIDDTELIDGLVLSQSVIKTTGGPIRIEKAKIGLIQFQLSPPKPDLENQIIVNDYRQMDRILKEERQYILNICKKIKKTGCNVLLIQKSILRDAVNDLSLHFLSKLKILVIKDIERDEIEFICKSTGCKPIADIDSFTEDKLGSADLVEEVQSYGEHIVKITGVKGSVKTVSILCRGANQLVLEEAERSLHDALCVIRCLVKKRALIAGGGAPEIEASQHLMKLARTLSGTEAFCFQAFAEALEVIPITLAENAGLDSIKIITELRNRHEKGEITAGINVRKGMVTNILEENIFQPLLVSTSALELSAETCKMILKVDDLTFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWN9</accession>
    <name>M7NWN9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00136</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871997.1">
        <property type="nucleotide sequence ID" value="XM_007873806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWN9"/>
    <dbReference type="STRING" id="1069680.M7NWN9"/>
    <dbReference type="GeneID" id="19893834"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00136"/>
    <dbReference type="eggNOG" id="KOG1601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_886008_0_0_1"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF335">
        <property type="entry name" value="IRON-SENSING TRANSCRIPTIONAL REPRESSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="9">
        <location>
            <begin position="200"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="9">
        <location>
            <begin position="257"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="314" mass="36318" checksum="FFCDDF19CC0F8173" modified="2013-05-29" version="1">MAKSYFIFLEYPIHMKESDKTLGVDVKFSRENHTSVNKNNVHNPYMDIKGRSSLSSRDNNMYINYDYVSEVKNEEYFDHVLSSASASECSLVDSLATPFLKYSESNSFFVDINQIFRQGEHFFPSNSTFNIADTLDIPGVVNLGEDIYNERSNNDSYGPNKIIVGDSNNLNDVLEISSLDNASTIEKNDSIPPNTRKNVCFNCGVNETPLWRRSPDKKYLLCNACGLYLKQYKYMRPLGFHRKKSSSSQRSSIKLVCVNCEVTETSLWRKNELGKPICNACRLYEKIHNTQRPVTMRKEQVIRRRRYKNLFEHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWQ1</accession>
    <name>M7NWQ1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sorting nexin-4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Autophagy-related protein 24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_00146</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872007.1">
        <property type="nucleotide sequence ID" value="XM_007873816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWQ1"/>
    <dbReference type="STRING" id="1069680.M7NWQ1"/>
    <dbReference type="GeneID" id="19893844"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00146"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027221_0_0_1"/>
    <dbReference type="OMA" id="LQKSGHY"/>
    <dbReference type="OrthoDB" id="205639at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949:SF2">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="11">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR11712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="374" mass="44282" checksum="1187D08B3322AD70" modified="2013-05-29" version="1">MSFTQKPKSAVRRRFSDFIYLYETLTVEFPTCCIPPLPDKHRIKYIKGDRFSTEFTMKRANSLERFLQRLSMHPVLQKSLHLSHFFESQDWSSYVHNVILHDKTHYINIGGVFEGLSDAFLNSFTKINNPNMLFIDMKEKIDKLDYGLVHIEKLISKMIKQKIDLEMDYSGMAFLFKQLAVLEPSLSRELTMFSEVIENTETNLKILREYIDSVYLTFIHDLISYTNTQKQLLKQRDQKQMDIEGLTEYLMKVDLEKERVIQSSGLLYLREKVENLTGIDHEQAKQDRLKKLEKKKDKLQKEIEISKIAGDTFDEETIRENNIFDKIKTKEIQESFSTFANENINFYKQVIENWTKIIPELEHAKQKNIINQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWW8</accession>
    <name>M7NWW8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">26S proteasome regulatory subunit 7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_00094</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871951.1">
        <property type="nucleotide sequence ID" value="XM_007873760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWW8"/>
    <dbReference type="STRING" id="1069680.M7NWW8"/>
    <dbReference type="GeneID" id="19893792"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00094"/>
    <dbReference type="eggNOG" id="KOG0729">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_6_1_1"/>
    <dbReference type="OMA" id="RSKYHIE"/>
    <dbReference type="OrthoDB" id="1937997at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045899">
        <property type="term" value="P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000005">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048723">
        <property type="entry name" value="OB_PRS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21236">
        <property type="entry name" value="OB_PRS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="211"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR11656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="436" mass="49517" checksum="33A1D69B0D574597" modified="2013-05-29" version="1">MPPKENWEEYKKVVDDDKEEEKIVPLDDGDILLLKTYGTGPYHDLLSKIDTDIKELQKKVNEVLGVKEAETGVLDRRFWDLAKDRQRMSEEQPLQVARCTKIIQNKDDLEANKYVINVKQIAKFVVKLGDRVSPTDIEEGMRVGVERQKYAIQLPLPPKIDPSVTMMQVEDKPDVTYNDIGGCKEQIEKLREVVELPLLLPERFVNLGIDPPKGIMLYGPPGTGKTLCARAVANRTDATFIRVIGSELVQKYVGEGARMVRELFEMARTKRACIIFFDEVDAIGGTRFDDGAGGDNEVQRTMLELITQLDGFDPRGNIKVMFATNRPDTLDPALLRPGRIDRKVEFNLPDLEGRTNILKIHTRSMSVDRDIRWELISRLCPNTTGAELRSVCTEAGMFAIRARRKVVTEKDFLESVNKVIKGNQKFSSTSQYLQFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NX79</accession>
    <name>M7NX79_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL14m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00188</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872051.1">
        <property type="nucleotide sequence ID" value="XM_007873860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NX79"/>
    <dbReference type="STRING" id="1069680.M7NX79"/>
    <dbReference type="GeneID" id="19893886"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00188"/>
    <dbReference type="eggNOG" id="KOG0901">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095071_2_0_1"/>
    <dbReference type="OMA" id="IVCVVQK"/>
    <dbReference type="OrthoDB" id="274765at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000005">
        <property type="entry name" value="50S ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_uL14_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="128" mass="14289" checksum="DBFA3D217EC92231" modified="2013-05-29" version="1">MINLKTMLYVADNSGAQMAECINILKSGKYARIGDEIVVVIQKIRSSSMSTGSLNANRIRRGDIKHALVIRTKKETRRKDGRSIRFDDNACILINKKEPIGTRILGVVSAELKYKGWSKILSLAQKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M7NXC7</accession>
    <name>M7NXC7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00242</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Clp1 family. NOL9/GRC3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872111.1">
        <property type="nucleotide sequence ID" value="XM_007873920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NXC7"/>
    <dbReference type="STRING" id="1069680.M7NXC7"/>
    <dbReference type="GeneID" id="19893940"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00242"/>
    <dbReference type="eggNOG" id="KOG2750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010345_1_1_1"/>
    <dbReference type="OMA" id="EHVWKVR"/>
    <dbReference type="OrthoDB" id="4054781at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000448">
        <property type="term" value="P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF3">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Clp1 P-loop" evidence="8">
        <location>
            <begin position="221"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="611" mass="69384" checksum="08FAC1EBDAA9BA6F" modified="2013-05-29" version="1">MTLSALEAHKKYKSINTEDKRTNSNYERVQAITKTEQNNNDHNTTNNFDFSNTDIVLKNINEISIKKNLQIISKPSINKQFLDKNGCTVEIFGFYTEEKLILQGFYEFKVIKGIISIMSSEFDSSNTSQWYRIFSLTTDSIPVISSVLSNKNSIETSCFIHSKEICSFIRMLDSFLESIICIIDDFSNHPLLNIPESWLSAIDIIHSSNFDNKTARIIICGPKSSGKSTFAKNLINKFLTGKYNKHKTIEGINYIETDLGQPEFSPHGIISSHYIKKPVINPSFTHCTLPSLTKAHFLGNISPQNNPKHFLLCINDIFNTNKRNIPTIINTPGWTKGMGLELLNEIINLSNCTYLVYIGPKTNVEIFDTELILPSSVELLTLPSAREFINTCGTVKTNTADLRELSIISYFHSINISEDNCHTNWEFDSYLLDMKPWIVKYDGDLNGIDAISVLNTTLDIEEFYYAINGTIMAFVVADDITKNNENTWKSIITKSKDCLPILNMEKNPIDPKISQCIGLCILRGISRKSKELQILTPIDTLTLNKYLNSNKKIILVRGNLELPISLMINCKKNKDAKIDWNKAPYLSLENEGLGSKVWHPRKNIERPAMRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>M7P2H8</accession>
    <name>M7P2H8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate kinase</fullName>
            <ecNumber evidence="6">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate kinase cytosolic and mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ADK1</name>
        <name evidence="9" type="ORF">PNEG_03525</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <text evidence="6">Predominantly mitochondrial.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the adenylate kinase family. AK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6"/>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875617.1">
        <property type="nucleotide sequence ID" value="XM_007877426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P2H8"/>
    <dbReference type="STRING" id="1069680.M7P2H8"/>
    <dbReference type="GeneID" id="19897212"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03525"/>
    <dbReference type="eggNOG" id="KOG3078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032354_1_0_1"/>
    <dbReference type="OMA" id="VYHEQTA"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03168">
        <property type="entry name" value="Adenylate_kinase_AK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028587">
        <property type="entry name" value="AK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001381">
        <property type="entry name" value="PRK00279.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011100">
        <property type="entry name" value="PRK14527.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="8">
        <location>
            <begin position="162"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="6">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="6">
        <location>
            <begin position="161"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="44"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="120"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="171"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="258" mass="29980" checksum="41299EAF6F62D36E" modified="2013-05-29" version="1">MELIQREIDRIQEGFFHFQEYLGFQKKTDKKHQELRMILIGPPGSGKGTQAPKIKKEFCICHLATGDMLRSHVVRKTSLGQKAKTIMDKGELINDEIMINMIKNELSENKECKNGFILDGFPRTILQAKKLDKMLEENGKRIDYVFEFQIHDELLIHRITGRLIHLPSGRTYHKDLYPPKQPMKDDITGEPLIQRSDDNIETLKSRLKAYREQTSPVVNYYKSRGIWIGLDATQNPTKVWQSIQSIFANPYQKEAFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3I5</accession>
    <name>M7P3I5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Asparagine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="2">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Asparaginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_03237</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875303.1">
        <property type="nucleotide sequence ID" value="XM_007877112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P3I5"/>
    <dbReference type="STRING" id="1069680.M7P3I5"/>
    <dbReference type="GeneID" id="19896924"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03237"/>
    <dbReference type="eggNOG" id="KOG0554">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_0_1"/>
    <dbReference type="OMA" id="PEMAFYD"/>
    <dbReference type="OrthoDB" id="43906at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070145">
        <property type="term" value="P:mitochondrial asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04318">
        <property type="entry name" value="EcAsnRS_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000016">
        <property type="entry name" value="Asparagine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003037">
        <property type="entry name" value="PRK03932.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF34">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="148"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR08400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="475" mass="55241" checksum="2877FDFCC4C04A34" modified="2013-05-29" version="1">MISRYFKKKIHNLRISKTCSVKDAIEKQVNPNQIITVYGWIRSLRKMKNVTFALINDGTTGKNMQAVLKPDQGKGLSTGCSVKLTGLYRTTQGGSKEKQEYELHVNDLQICGYSDPSSYPLQKKHHDLEYLREKAHLRLRTESMSRLLRLRSFLISIISSFFSNKDYIQTHPPILTSSDCEGSGKIFKVESSNESDNFFKKNTYLTVSTQLHLEALSHSLSKVWSLSPTFRAEKSRTSKHLAEFYMLEAEISFINDIEDLMSIVEQMIHDLVENLKNSSIGNEMITENYKTNKRDQINLENRWNFFLKEHWTRITYAEAINALKNSSVHFKFPPKYGHDLQTEHEKWLTEKYTHSPLFIINYPKELKPFYMRLNNDSLKYEDHNTVSCFDLLIPQIGELAGGSLREERIDILKQSISTRKTHLSNLSWYIDLRRWGTAKHGGFGLGFDRFIAYLAGIKNIKDVMAFPRWHQHCNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3S2</accession>
    <name>M7P3S2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02993</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875042.1">
        <property type="nucleotide sequence ID" value="XM_007876851.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P3S2"/>
    <dbReference type="STRING" id="1069680.M7P3S2"/>
    <dbReference type="GeneID" id="19896680"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02993"/>
    <dbReference type="eggNOG" id="KOG1820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008401_1_0_1"/>
    <dbReference type="OMA" id="ACLNTIM"/>
    <dbReference type="OrthoDB" id="205662at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990498">
        <property type="term" value="C:mitotic spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099070">
        <property type="term" value="C:static microtubule bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061863">
        <property type="term" value="F:microtubule plus end polymerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990571">
        <property type="term" value="P:meiotic centromere clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000019">
        <property type="entry name" value="Cytoskeleton-associated protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000063">
        <property type="entry name" value="Putative cytoskeleton-associated protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045110">
        <property type="entry name" value="XMAP215"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048491">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12609">
        <property type="entry name" value="MICROTUBULE ASSOCIATED PROTEIN XMAP215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21041">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="6">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="6">
        <location>
            <begin position="265"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="713"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="628"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="827" mass="93486" checksum="FF789B6C73AB4CBF" modified="2013-05-29" version="1">MAEQEDYSSLSLLERAIHKLWKVRLEAYEEMSKLFSISTSEQDPIFRSFLLDIGLWKRICTDSNVFAQEAGIKALKDFLEFCGKEACIRTRSTVIPCIVEKCLTSTRVGTRKKSIDIVLLYVELDSPDPVLDDLLPGLNAKFPKLVAATANAIKEIYRLFGLKTVDPKLALKILPKLFAHSDNNVRKEATELAVILYSWLGDAVKSSLFSELKHVQIKELESSFEGVKVGKVAQERYLRSQQILSENSSQVPLQNNESENIDFFDSLEPINILSKIPKDFNDQLASTKWKDRKDALDSLYSICKVPRIMEDDYNDVIRLLARSIKDVNISVVIVASNCVEAFARGLRKGFIKYKSIVFGPIIEKLKERKATVIDALTNAMDAIFDATSLSDVLDDILEFSKHKNPQIRSEILVFLVRCLKCTCIYPKASEIKLIAESSKILLNDTFEPVRNSSAEIIGILMKIAGERQMGFILDGVDDLRRVKIREYFESAEVKIKHESLKHSVLFDDSKSNKFNSLENPNSMVVPSNDAKKTLLRPSSFKRKDSQSLKVSFLGSRLPSTVDHIGIKSGLKVSSRRPVSLQNIKSDNDVVNSSFRAVKNTGSVLQTSAKSIEQTIELGNLSISDKRELEELRKENLKLDERLQKEVSEKENLLNEINSLQLKNAQLINDHTRDILKIKATETQLSRARNEIEMMKSQLLSLRKELDQSRLNVSNRSANFQNPTSSDDKIGNSSLNVNESDNNSPKQNQHISISGVDSSFDIEKENSHSNFSIFSKYCNGFSSSSSLEYFNTSFSKSDNISSWDNAADLTARLKERIEQMKRADMRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3V1</accession>
    <name>M7P3V1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_03021</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DCP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875072.1">
        <property type="nucleotide sequence ID" value="XM_007876881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P3V1"/>
    <dbReference type="STRING" id="1069680.M7P3V1"/>
    <dbReference type="GeneID" id="19896708"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03021"/>
    <dbReference type="eggNOG" id="KOG2868">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152856_0_0_1"/>
    <dbReference type="OMA" id="QVLKFHY"/>
    <dbReference type="OrthoDB" id="440673at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13182">
        <property type="entry name" value="EVH1-like_Dcp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010334">
        <property type="entry name" value="Dcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290:SF0">
        <property type="entry name" value="DECAPPING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290">
        <property type="entry name" value="TRANSCRIPTION FACTOR SMIF DECAPPING ENZYME DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06058">
        <property type="entry name" value="DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14985" checksum="6E597322B5A9C1FB" modified="2013-05-29" version="1">MQQTTLYDLNLRVLHKHYPSIISILASSPYVVLYSFSDSKKTWTKEHCEGTLFIFSTNKGYSYTILNRLSLESFSANLIYPDDLEYSDPYIIHKINNNEIYGLWIWEAFDRQKISSVMINCAKRNVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7P443</accession>
    <name>M7P443_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_03111</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Cd(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48775"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875167.1">
        <property type="nucleotide sequence ID" value="XM_007876976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P443"/>
    <dbReference type="STRING" id="1069680.M7P443"/>
    <dbReference type="GeneID" id="19896798"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03111"/>
    <dbReference type="eggNOG" id="ENOG502QPP7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026885_0_0_1"/>
    <dbReference type="OMA" id="DECTEKH"/>
    <dbReference type="OrthoDB" id="2338at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337:SF0">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0104">Cadmium</keyword>
    <keyword evidence="5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="366" mass="42187" checksum="A339FB304EAAE076" modified="2013-05-29" version="1">MSIILILNINIPVVNIARIAGQFSKPRSKSTEIINGKEVLCFRGECINGYSSDERKPDPERMLKAYFHSSTTLNYIRLLSSSREDGLYTLLESDYSFLLDNNLGKECFTNIKSFDLSNLKKINGLDSNFLLKKPYIFTSHEGLLLEYEECMTRKIRDPETNEEKWWNLGAHFLWIGDRTRDIDGAHVEYFRGIENPIGIKIGPTLKPDELVRLLDIVDPNKELGKVTLIFRYGYDKIKTYFPQHIKAIQSSDHKVIFVCDPMHGNTLFSTEYPSYKTRKFSHILLELKLCFNICKAYGSHLDGVHFELTGEEVTECLGGSMQLEDKDLPKTYKTLCDPRLNYKQSLEIAFLIAKYWKKYQDPASSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7P4P8</accession>
    <name>M7P4P8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02960</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875005.1">
        <property type="nucleotide sequence ID" value="XM_007876814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P4P8"/>
    <dbReference type="STRING" id="1069680.M7P4P8"/>
    <dbReference type="GeneID" id="19896647"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02960"/>
    <dbReference type="eggNOG" id="KOG1650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_10_0_1"/>
    <dbReference type="OMA" id="QVKVERW"/>
    <dbReference type="OrthoDB" id="2687058at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050794">
        <property type="entry name" value="CPA2_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468">
        <property type="entry name" value="CATION/H + ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468:SF0">
        <property type="entry name" value="K(+)_H(+) ANTIPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="8">
        <location>
            <begin position="42"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="936" mass="103618" checksum="E48B00F59C233037" modified="2013-05-29" version="1">MGTSKEAIHSGVGVFNGESPSAYNPENPITLFIIQCIIIIGFCRLLHLPLSRLKQPRVIAEIIAGILLGPSALGKIPYFNNHIFPKDSLVILNLASNIGLVFFLFVVGMEVDIRVIRRHFKVALSVGLGSLLLPFAGGVAVAYGLNKEFNDNKEINLAVFFIFIGTAFSITAFPVLARILTELKLLQENVGIVVLSAGVGNDMIGWVLLALTIALVHAGSGLISLYVLLLGISWVLILIYIIRPIFIALVRKTKSLENGPTEFIIAITFFLVLGSAFVTDIIGVHPIFGGFLAGLIIPHISDFAVKVTEKVEDLITILFLPLYFASSGLKTDITLLNDKISWAWTICIIFTVIITKVIGSSLAARINGLLWRESFTIGILMSCRGLIELIVLNVGLTANIINPKIFTMFVVNAVLTTSLTTPSVLLLYPLWYREKVKRWRAGKIDWKNISTKFNSKDENTFNNSIVPITINKLMVVLNRVEHLPPLMAFIRLLSPVSSVKADHSPNTCLDALDITEEIEVPLSIHGLRLIELTQRTSAIIKVSDNGESNKLDPLMNVFRTFVRLNRLRVSGSLKFASEEEFSSSVIEQAKEIGAEFLIIPWSTDGSISDESEKSFKRISSSFVQKYTTARHNEYVESIFDSVHCGIGVLIDRGLAGNIVHENFDPQLSDLDRKVSSSFLTQYDTISYTNTMFENSTPSDGRYHIFFPFFGGEDDRAALNIVFQLVTNPAISVTIFRIKAIEKSISNSPHCLSMTNTKESHSFEAPKKNYSAHLQHFNMQFRSDLPRQVSMSQMPLEYDETKCAIISDSQNSVQSELDDRFIETCMNSILQKHSSRVSLEIVNSTVPLQHALSLAKREISKHKYYGGGSLIILGRSCRNPNSYIRKDLINMLKASDYPTGGGSGLRRCLGDSAEAFLIAKIRASILIIQAPSSSKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7P515</accession>
    <name>M7P515_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADH-ubiquinone oxidoreductase 19.3 kDa subunit, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02725</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874751.1">
        <property type="nucleotide sequence ID" value="XM_007876560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P515"/>
    <dbReference type="STRING" id="1069680.M7P515"/>
    <dbReference type="GeneID" id="19896416"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02725"/>
    <dbReference type="eggNOG" id="KOG1687">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055737_7_3_1"/>
    <dbReference type="OMA" id="GCGGIEM"/>
    <dbReference type="OrthoDB" id="268400at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12280:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit B 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005012">
        <property type="entry name" value="PRK06411.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56770">
        <property type="entry name" value="HydA/Nqo6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase-like 20kDa subunit" evidence="4">
        <location>
            <begin position="83"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="208" mass="23903" checksum="0E639D9A191F7BBE" modified="2013-05-29" version="1">MIYLSRLTVFSRGFDDKIRRMFISSWRPFNLLKKKEILGESNGDLIPWKKEKSSLDYVLTSVDAIVNWARQGSIWPMTFGLACCAVEMMHASAPRYDQDRLGIIFRASPRQSDVMIVAGTLTNKMAPALRQVYDQMPEPRWVISMGSCANGGGYYHYSYSVVRGCDRIIPVDIYVPGCPPTSEALLYGIFLLQKKQRNQKITRLWYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7P543</accession>
    <name>M7P543_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="20 21">NADPH--cytochrome P450 reductase</fullName>
            <shortName evidence="20">CPR</shortName>
            <shortName evidence="20">P450R</shortName>
            <ecNumber evidence="20 21">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PNEG_02760</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 20 21">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="20">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="20">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20">Endoplasmic reticulum membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Mitochondrion outer membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Cell membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the NADPH--cytochrome P450 reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20 21">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="20 21"/>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874791.1">
        <property type="nucleotide sequence ID" value="XM_007876600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P543"/>
    <dbReference type="STRING" id="1069680.M7P543"/>
    <dbReference type="GeneID" id="19896451"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02760"/>
    <dbReference type="eggNOG" id="KOG1158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QKRYQRD"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06204">
        <property type="entry name" value="CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000009">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000024">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000018">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03212">
        <property type="entry name" value="NCPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 20" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 20 21" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 20" id="KW-0274">FAD</keyword>
    <keyword evidence="3 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 20" id="KW-0288">FMN</keyword>
    <keyword evidence="2 20" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 20 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="15 20" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 20" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9 20 21" id="KW-0521">NADP</keyword>
    <keyword evidence="12 20 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 20" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="18 20" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 20" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="17 20" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="22">
        <location>
            <begin position="72"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="23">
        <location>
            <begin position="282"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="78"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="456"/>
            <end position="459"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="474"/>
            <end position="476"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="491"/>
            <end position="494"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="557"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="619"/>
            <end position="620"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="625"/>
            <end position="629"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="661"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="699"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRNR" id="PIRNR000208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EMR08985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="700" mass="80860" checksum="409ADCD11F0F4E85" modified="2013-05-29" version="1">MFKEKQELTLDAFDIIFIFAILTTIIYIFRGKLWTKKGSMLSIFNNSTNDTLIIPKNTRNIIQKMHDSQKSVVIFYGSQTGTAEDLAFRLAKEGHARYGLSTMTANFEDYDYENLNDFPAEKMAIFVVATYGEGEPTDNAIEFFKFLQSKNLTFSNGDTINNRPLSNLNYIIFGLGNSTYEYYNHMARTLDTLLIKLGANKISKRGEGDDSNATLEEDFLSWKDKMWADVAKKMNLREKEAIYIPEFEIIEDLRLSSSLETVFLGELNKEYLIGKIKPFNSYNPFIAPVIESHELFFSGKRNCLHMEFSIKDSGMKYQTGDHLAIWPSNSNQEVDRLLTILNLAHKRNTVIRVKNIDPIAKVPIPQPSTYDSIVRYYLEICAPVSRQSLTTLAQFAPSKEAKKETLRLGSDKNYFHKIISSRCFNLAQTMQFITSELWTKVPFSFIIECFTRLKPRYYSISSSSLIYPTKVHITAVVESKFFPENDNILNGVTTNYLLALKQKQNGDIDTRSFEINYELDGPRNKYRNFHLPVYIRRSNFHLPHNPTIPIIMVGPGTGVAPFRAFVMERAEQMKRGKKIGKTILFYGCRYKNVDFLYKNEWEEYKNIMGDLFEMYIAFSRETNKKVYVQDLLEQNSSKINKILESGGIFYICGNAARMAREVNITLHKIISEERGIGKIKGNEVIRKMRNENKLFEDIWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7P544</accession>
    <name>M7P544_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U3 small nucleolar RNA-associated protein 6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02766</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874796.1">
        <property type="nucleotide sequence ID" value="XM_007876605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P544"/>
    <dbReference type="STRING" id="1069680.M7P544"/>
    <dbReference type="GeneID" id="19896455"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02766"/>
    <dbReference type="eggNOG" id="KOG2396">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026025_3_0_1"/>
    <dbReference type="OMA" id="KTANEYM"/>
    <dbReference type="OrthoDB" id="28112at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013949">
        <property type="entry name" value="Utp6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055347">
        <property type="entry name" value="UTP6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08640">
        <property type="entry name" value="U3_assoc_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 N-terminal" evidence="6">
        <location>
            <begin position="9"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="427" mass="50451" checksum="19EE1063536DE4C9" modified="2013-05-29" version="1">MSEKAEYFLEQSFPEIIDLQRRSIFTPTEIKSIIKRRTEFEYALARRIVKKEDFLKYVEYEMNLEALRKKRIKRLNIKGKPTISDWGGVRRIFFIFERATQKFHGDIDLWLQYIRYAQHEKSTKLLGKVISKALQFHPTKPKLWIFAGYHELNWNGNISAARVLMQRGIRLNMYSSELWLEYCKMELIYIIKLYMRHKILGISELSDDKNVNKAAKEKDMIMIPEITYEEYKKDNLIFKNMETSLSDSKNVSLIDFQDSPVMKGEIVSIIIKTANEYMPKNIDLLESFYYMIESLENLICRDRLLNEIVSLIEYQESNIELAKILLLILPLNKFLKNVLDISFPGVLKSSILGFNTLIENNNCSIISYEKFCLFLGKFLKKKKLDENLRIVIHSFLYSILKKLEIQHLMSPKLKILLDSICLQCIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>M7P576</accession>
    <name>M7P576_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02803</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874836.1">
        <property type="nucleotide sequence ID" value="XM_007876645.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7P576"/>
    <dbReference type="GeneID" id="19896492"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02803"/>
    <dbReference type="eggNOG" id="KOG1450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4407">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_235153_0_0_1"/>
    <dbReference type="OMA" id="ELYPREW"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF96">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN BEM2_IPL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="3">
        <location>
            <begin position="567"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="4">
        <location>
            <begin position="1020"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="1726"/>
            <end position="1918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1933" mass="224891" checksum="22D63FA7180563BC" modified="2013-05-29" version="1">MKSNKKEKRKSDSKYLYKDIENLCVDNNKSKNKQRFNHIFFYSRKIQKISNSHKHEGMMKQEHGGMDLDKSCEQDCLDGSMDQSFSDQISQYLHAPASQSLNNLNMPSNYMSSLDSSKVIFKKRNVLTKNTPSISWKKKKSTQKHRIDCQEHSVSLLSDSIIHKGWLNRMDETDHKFSGFSNSCNNWKLCMTILSGSKLYFYTPQEISNSSYNVMYSYDLQNTSDSMEYKFSSSEFDLNVRSILYDTNNLQRFFFGVILTEFEGFIQDFEKDMNSIFFIENILVLCYRGSFIFNKDQDLHPNSNAHNIDLKKLWKLDVVYNVFDVNIVFNLLKNVNLVSSELFGEDLYLMTINNEEIIRRFILSKESAICFLKKYSLFQKLTKSVEFSILKNTALTEFNSMSISNDVQDILLNYDKTLKATTTRILLEIMLGINNTTTNFDIFELFSTLIGFWDSSETILGTIISIVSESLVDFSSSIEKMINIWCDKCYGMFQDSNIIDNIEKLIKNGIDPNNSILSQKLRNKIKNKELTLKSDLFDLIAIDFSIYKIYDNNLEFGLSVEAILEIPPEVFSRELYYFHQRFLNTWDPSLDLSLFFNKVSFNLIRNPLIFGHRHIHFITRLVLEQLLKTNDKMSSQLRANICAYWISVSICLKNFGDMAGWFSIIIALCSPSIIRLRETWTLVDLNLRNFVQNSASIMNDLHEFDFYMTDKTIYMPDTLISDKLSKIEISKQTIPYYGEILNYIENFISFYGSNNKLINIELFNDIFILVKKKLERWRCIVLANKSFICIGDENRSIILQELFKQLNCVRSNPQSIFSDVFFKKSLKCEPLKRSLSLQFDFSQNINTKSGICAFLIFNYIYNSCSLHDFMDLSEIYKDQNVYTDIETYSITEDSSLYNPLVQVSDLEKLNKHLKRSSFPFNRYSMLITDFDFDSKIRYKTVNLRDKSSLISKNSQDVFGENESLFYYVDGELVLRSIRNISEKKGSNCVKLSSKDNNILKVFENEKTCDNVNPLRTILSYQVIVKAGSLERLIDVLVLGIDDFSERLIHESKNIQLDLYMNTGDFRLIFFSIFRSFCAPFTLLEHFKKRLAGSKAIASRIGVNMKVSEYAKNNRMFPDWTSSDSSNYSLFNYDFYLKIHVGVLECVILWLTHYFDDFVDDLSMLDGFYSFLKLANDQLQNWKEIVSTKNELQYYMSQYLDLFENLRKLFAKLSYQPQIELSHVISIKILQEIDISSEYSDEDLFNLAYTLDRLTASIFKKLTLEDWIYCFELFQVQFRDLESFFEYHESISLQNDNYVLQDTYSLLSQIRGSQSHDLLINMFPHSIRELFRLRHNIIKWVISQITDINIDCCTRVNRILLYLRLLGVYKLTMTHLDFFSGPFDGNDLIKDKSMLPSFVGNAIAAALVRPESRLFIYAWSMVASARGLNGQVEDLASIIPLVTVKNSFSFTPCIGWIFQRMLKIVFCIPDVIGNSQLINFIKYTFLYDFILRVIGFGNHENFEVNQQTDKCDNTNDIIVNIRTHDLRTLEMVSENENYPLQFSNIRKPFESLIQKKIITIQKNQKHCGSIKKHLEGLNKDIKRENVNVSKICEEDHKKVALKHKGNNSFWSSHSSSMFMNNSTKDKVLALESEPLDVIDLVDSSVSTLKNSKHECVFRIKSRNGIKILLRAPSVDEYKIWYKKLKDLSAITFNKKKNILMKDTHAASVNIAVKIPSVGLDSTTCYGVDLETLCCREKSNIPKIVNDLIIEIEARGLQEVGIYRVPGSVSKVNSLKTLFDAGENVDFKDGRWADINIIAGALKLWLRELPEPLMTYKLYPKFIGLVDISDYHKRIILLKTLIRSLPFYNYFLVKRLVEHFEKIINYETVNQMYAHNLAIIFGPNFLQPFPSNYSFSQTVTHLGKAQEVIKELIIHRNSIFYDRNSSQMSFHLQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7P725</accession>
    <name>M7P725_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01872</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873846.1">
        <property type="nucleotide sequence ID" value="XM_007875655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P725"/>
    <dbReference type="STRING" id="1069680.M7P725"/>
    <dbReference type="GeneID" id="19895566"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01872"/>
    <dbReference type="eggNOG" id="ENOG502RYK5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_602903_0_0_1"/>
    <dbReference type="OMA" id="QQSCFQY"/>
    <dbReference type="OrthoDB" id="5310959at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019680">
        <property type="entry name" value="Mediator_Med1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041:SF4">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10744">
        <property type="entry name" value="Med1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med1" evidence="8">
        <location>
            <begin position="39"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="490" mass="56959" checksum="D571B57CB0BF58A4" modified="2013-05-29" version="1">MFLNFKNSSLNKILSDLNDYVKNNNFTSVESVDVAIHALEEGKIDDFISAEALETLGKKEGLECFQDKYENKVTISLGGKIIVIDIDLEKFSIYWKVIRVTTTWADCKGGQYFSPSTDAILLANFSESYRLNLFKSNFQRLLRFDRLSSPPIWDAFSAIRSLYVAFEQIYGYELEIYKDPEKILCEKFGKPEFDVANIVGLTLWYWKQRRYCSTEEKLWRVIIEVEEQDTTASSISPAVNIQWIDQKITLLNGDYNWMEPSSSFSSSCQFVMILDPPVIVCTEDIKQISRIIKSYDFISQNDLEKNNYQVYETILTSQSLPIQTERILYLPFSVTQHQLYTLEKSTLSPACHLNRIPFSHPKQIHSILKLLRKYILFQTLTESYINNNVSSNSLLHKTNYKSYIKNKTNFNISTFYETNIQISIFSSTIDDLKIILSITENGHIHLQDLHTNKSLPEDIKLEIEHVFQISEDIGITCEYIRQILNRNDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7P739</accession>
    <name>M7P739_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Signal recognition particle receptor subunit alpha homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Docking protein alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_01882</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endomembrane system</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873856.1">
        <property type="nucleotide sequence ID" value="XM_007875665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P739"/>
    <dbReference type="STRING" id="1069680.M7P739"/>
    <dbReference type="GeneID" id="19895576"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01882"/>
    <dbReference type="eggNOG" id="KOG0781">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_8_1_1"/>
    <dbReference type="OMA" id="HLGWIDK"/>
    <dbReference type="OrthoDB" id="1727884at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005785">
        <property type="term" value="C:signal recognition particle receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14826">
        <property type="entry name" value="SR_alpha_SRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000566">
        <property type="entry name" value="Signal recognition particle receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007222">
        <property type="entry name" value="Sig_recog_particle_rcpt_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF1">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04086">
        <property type="entry name" value="SRP-alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="12">
        <location>
            <begin position="567"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00081194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR09695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="594" mass="67767" checksum="89341BD3BA0CF4B0" modified="2013-05-29" version="1">MLVLFTIFNRGGIVLWERSFDVLPFNIINDFINDIFIEEQMSKTIYIKEDFAVKWTVSNDFGLVFAVVYLSLSELVYVEEFLENIKKLFCQLYNEDLKKKDFFSKNFSFDSYFDVKIDEFNALNTKKLPSFASKKDIITDNYSFSKDSEENNDIAHQHVQMSNVFETMKTRFPLKKDLHKRNISKNTKKNNPKISNLSNKEYVKKNKKVMRKWEDDYIIDSNCEADTLDYSIEPEKSSVSIQNDILDLSKENLSSKNGKVFFIKEIDDDNDGINGKNDKKEPNTWVLNIFTNLVKKRVLSLDEINPALTKMKELLLKKNIAKGVVDNICESVQNNLIGKNVGTFQSIHTIIKTTMESTLKQILTPSASIDLLKEIDDSKAQKRPYTISFVGFNGVGKSTTLSKIAFWLLKNHLKILVAACDTFRSGAIEQLQVHVRNLQQLSEREKCGKIELFEKGYGKDANIIANNSILYAKKKEFDVVLIDTSGRRHNDTRLMSPLEKLVTTENIDKVFQVAEALAGADVVSQAKNFNNALGYKRKLDGFIISKMDTVGNVIGTIVSITWATGIPIIFIGNGQTYTDIRVLSVSWAVKMLMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7P7D1</accession>
    <name>M7P7D1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873916.1">
        <property type="nucleotide sequence ID" value="XM_007875725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P7D1"/>
    <dbReference type="STRING" id="1069680.M7P7D1"/>
    <dbReference type="GeneID" id="19895634"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01940"/>
    <dbReference type="eggNOG" id="KOG1274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RYAHTNG"/>
    <dbReference type="OrthoDB" id="427368at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903461">
        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057646">
        <property type="entry name" value="WD40_WDHD1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022100">
        <property type="entry name" value="WDHD1/CFT4_beta-prop_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048591">
        <property type="entry name" value="WDHD1/CFT4_hel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932:SF10">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20946">
        <property type="entry name" value="Ctf4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12341">
        <property type="entry name" value="Mcl1_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24817">
        <property type="entry name" value="WD40_WDHD1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDHD1 first WD40" evidence="8">
        <location>
            <begin position="9"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="226"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 second beta-propeller" evidence="6">
        <location>
            <begin position="406"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 helical bundle" evidence="7">
        <location>
            <begin position="707"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="804" mass="92402" checksum="DCDA6A98CD2139FE" modified="2013-05-29" version="1">MTTQRLIPRYAHTSGLTRLMYSKDGYFLITVGSNQVIRKFTVESDDEPLTIEHHQDAITGIAISKHQFATCSEDATVSLFSLETNECLTMLTRCSLPVREIAFSPDGEWLAVCSDEIRVKVVHTTNYLCSIYLPGFSKPMKHVSFDPNGKFITTSCTDGIIYIFSFSSEEPELVHTIDHIIPIYESESEGCSRVTWHPDARSFAVPTRINDIAVFSKSWEKRITFKSGHLEMITDISWSPNGAYLCSAGKDGKLLVWETKTQTIIVRQEYKNVISLAWHPKTNVLSFTTNQGQLYTFSNIIPSNYQEPYGRIAHLGPLLDETSIKDSITKKRYTNEFNKRELSDEDLIDIDNDMSWIEDDDGAGYVPKYKYNESRYEKSFDDLSDDDFYYTTKRVLDNHIKIKIHKPLQPGSTPWREKRRYLVLNLVGFIWTVDQDTHNTVTVEFFDKEAHRQYHFTDIFFYDKACLDDNGALFASSTKKGSPSVMFFRPHENWTIHTDWKIEFFEDEDILSIALSSSNIIACTSKGYLRSYTLNGIPLRIYRQKYFPVVACISWKNYVMVVSNGSLNSDGSVSLTYTLEHVLQDKVLQSNDLLALPPKGHLRSLFFSDEGDPMIFDSDGILLVLMHWRIHGQAKWVPLLDTNLMKRRKGKDESYWPVAVANQKFYCIILKGNEQHPYFPRPMFSEFEFLIPCVLLPESEEINNIYALEERHVRESILLTLLEDTIASSADNESDKLEISKKEISIDKILLQLLQIACKEDHQAKALEFATLLRRSTSLDAARKIAAHYMKTSLIERITALTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7P8G8</accession>
    <name>M7P8G8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01439</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873379.1">
        <property type="nucleotide sequence ID" value="XM_007875188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P8G8"/>
    <dbReference type="STRING" id="1069680.M7P8G8"/>
    <dbReference type="GeneID" id="19895136"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01439"/>
    <dbReference type="eggNOG" id="ENOG502RS1U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_533302_0_0_1"/>
    <dbReference type="OMA" id="NIEERDW"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="382"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="59939" checksum="21E73CFF70F179F2" modified="2013-05-29" version="1">MKPTCQFVVQRYPLFLYFLPYFHGFLANLGNKYRKVFGTRLYNGSLIHFCKKTRKNMMIPDSIIKESFNDKKISFQYKVSTGNLTAALNCYFELSKTGCLTKFDITKLVMLMYTHIRKVSPISIEDDDKRKLLFYLENILDDVRCNFVSDHPMIWVNAIYIYTVLGLYETGKKIWESLRSKYVSEPTSFDSRVYGAAIKLYSAMGSSLTECEALFEEAIHIININKMRKSLILYEGIIIARIENQDKKRALEGLQECLKEFKNIIKPIFFDSLIYNAVNKKDPQSVVDIVFYGLNSHYIPSPEALSKLFKELWIRDRNLLTILKIFRKYNEISCSIHIEHLNFILNALFKSTNRENQADVANTIEKVNNLLQVIYEANISPSISTFNTLISGYTYLKKFDYVEKTIEQMKQSNIPENEITLRVLLKKCGEKRDSLEKINAIWEKIVELASKNRKYIEEKDWITLLKILPHYKEKGIDLMTTFLQKYKSKTQNSTLKKIWHEFIKIQHSFND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M7P956</accession>
    <name>M7P956_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873584.1">
        <property type="nucleotide sequence ID" value="XM_007875393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P956"/>
    <dbReference type="STRING" id="1069680.M7P956"/>
    <dbReference type="GeneID" id="19895320"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01626"/>
    <dbReference type="eggNOG" id="ENOG502S35M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_561534_0_0_1"/>
    <dbReference type="OrthoDB" id="5396786at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013877">
        <property type="entry name" value="YAP-bd/ALF4/Glomulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040347">
        <property type="entry name" value="YBP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28020">
        <property type="entry name" value="YAP1-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28020:SF1">
        <property type="entry name" value="YAP1-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08568">
        <property type="entry name" value="Kinetochor_Ybp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="486" mass="57559" checksum="88949D62678ADC2E" modified="2013-05-29" version="1">MILNSVQIENGFLEWDTWFKETEDQCIDEKIQRLNNLENILIELGKKQIVENIVWEIVPRMLSFLKKESTLTEAQRILKICTEIGNAKELFLMYIEGLRSIKNDINLKNDERVANIKRYQKDGHITQIIILYKCLETVLLKIKTKHLSKFILDYSRTFISSVSVLHKYKANDKKLYDIIIKFAKQRVVGLSQLPNDYEEEKDKQRKILHSFIIQIFELFFKEKSNQWSLRYYRLINPYKISFQKNEHDIHLDSMVNSLKNVAVDTNFDFTISWKLGEILEIKDNSKEYQSYNLFSNNSIPSYGFLFLLGAYVFEDLYVIQDNTISKFLDHMKMTIISLNHGPITLSLIDTNLFLGLCILNNLQNISTINQEYFLEYTKTLSLISSSLEDSSLRFLSYTLIYQSLIRHSEDTTIIYINNILDTSPFKNLKTVVINILKDEIQRHWDVNYKHFLYNNYNNLGFFVTFYIFCLQFFTYKNISSKFIQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7P9U0</accession>
    <name>M7P9U0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ribose-phosphate pyrophosphokinase 1</fullName>
            <ecNumber evidence="4">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Phosphoribosyl pyrophosphate synthase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PNEG_01340</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873269.1">
        <property type="nucleotide sequence ID" value="XM_007875078.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P9U0"/>
    <dbReference type="STRING" id="1069680.M7P9U0"/>
    <dbReference type="GeneID" id="19895037"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01340"/>
    <dbReference type="eggNOG" id="KOG1448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_1_2_1"/>
    <dbReference type="OMA" id="CKMKKHR"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000017">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000043">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF57">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="17">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00077829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMR10640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="458" mass="50702" checksum="D846E5F0538AAD77" modified="2013-05-29" version="1">MRRTKIFGGSSHPELVEAITHHLAISPAPVSLKKFSNQETRVEIACSVRMEDVFIIQSGSNTINDHLMELLIMISACKGASASKITAVMPYFPYSKQSKMRRHRGAITAKMVANLLTVAGVDHIITMDLHASQIQGFFTKPVDNLFAEPSIAKWITENISDWKNAVVVSKNPGGAKRVTSLADILNINFALIHTDRKRKTFKESYSHISTNSYSPVTSNTESIDDNNYIYNSQENSYDDQTPILSGSSTPNELLSQKKTQSNRITCSNIRTARLISGHVVDDDYPSSVSPYCENSIDATHGPDSMFLPPFSFYSNTASIIGDTSTAISFNDDESINLNEERMITLVGDVENKTALILDDIIETPGSFVAAAEHLIKNCGAKRVFVFATHGILQNDCLEKMEECRCIDKIVITNTYPVSKKKRQTSSKLIIIDISKVFGEAIRRVHNGESISHLFGRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M7P9V5</accession>
    <name>M7P9V5_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873284.1">
        <property type="nucleotide sequence ID" value="XM_007875093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P9V5"/>
    <dbReference type="STRING" id="1069680.M7P9V5"/>
    <dbReference type="GeneID" id="19895051"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01354"/>
    <dbReference type="HOGENOM" id="CLU_700427_0_0_1"/>
    <dbReference type="OMA" id="TEMENMY"/>
    <dbReference type="OrthoDB" id="5342757at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="394" mass="45224" checksum="06537BC8EAB8283E" modified="2013-05-29" version="1">MSSRSELNTSPSPIWDSSDPQRRPPPLPMREEFTLNHIEGGGKLSRTSSISSHLYKQLGNKTSSQMLRISADDKTADIVHSISETTSTILGDLRSLIERSKDNASALLDLKQNIIDAKRDQKIIDEIRAIVTFLPQENDKEEKCDIFKEKLDEILKILNTNTSFHNTETRLLTDINKKLEAIEAFQDRLFSQKLEINNLISSYETLQQTNITEMENMYSRKVEMSAELARLDAHISQKKDSLDQLKERVKILENRLEDIQLKFNKQKEENKKLNKSSKKKVHQSAKSPTTPQNIRHFSLMDIHNRNPSIVTLAPSTIMNSPNNTDSVIDKKEKRKTSWSRKVVNAMGFQFQHNNKENSPVLSKNNELAIQKKKNYPNNFGIKTAKTFRSFSTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAE8</accession>
    <name>M7PAE8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tetratricopeptide SHNi-TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00957</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872870.1">
        <property type="nucleotide sequence ID" value="XM_007874679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PAE8"/>
    <dbReference type="STRING" id="1069680.M7PAE8"/>
    <dbReference type="GeneID" id="19894655"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00957"/>
    <dbReference type="eggNOG" id="KOG4563">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028900_1_0_1"/>
    <dbReference type="OMA" id="IAECHYK"/>
    <dbReference type="OrthoDB" id="5587616at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051730">
        <property type="entry name" value="NASP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019544">
        <property type="entry name" value="Tetratricopeptide_SHNi-TPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081:SF1">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10516">
        <property type="entry name" value="SHNi-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide SHNi-TPR" evidence="8">
        <location>
            <begin position="191"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="191"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="263"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="380" mass="43617" checksum="C3644D0D7C5EDCEC" modified="2013-05-29" version="1">MVEKEMQEIDSNGVLYSFPGPSESELSLEEAYSVVNEADRLYYKKDYEKAVEKYSLALERIVREYGEGDVRNADVFYSYGRALFHLAVKRSGVFGGVVPPLKNHTDIGSAFPKPLFNSSRLCFSGDESSDEESEDMVKEDDFSIAWEALDFSRFLYQKMLDINRGVSEKSSEDQKMGFVEENSITIEKKLADTYDLLGEISLENENFQQALVDFQSSLDLKIKIYPLESSLISEAHYKLALALEFLQESDLREKAIEHIHWAIKSLEKRLEIEQKSKKGKEKQEKEESEIQDMLLELRQKIKELEKNPEKTVVKTPDFENIVRNSQDVKKTLLDIISNANDVNALVKKKKKSISNGLPNIDENQQINQVHKKTKIENSCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7PBG7</accession>
    <name>M7PBG7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00814</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872721.1">
        <property type="nucleotide sequence ID" value="XM_007874530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PBG7"/>
    <dbReference type="STRING" id="1069680.M7PBG7"/>
    <dbReference type="GeneID" id="19894512"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00814"/>
    <dbReference type="eggNOG" id="KOG0877">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065898_0_3_1"/>
    <dbReference type="OMA" id="PYEEWSD"/>
    <dbReference type="OrthoDB" id="10253125at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000002">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000004">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="9">
        <location>
            <begin position="69"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="248" mass="27387" checksum="03D6C65CBBBE4A42" modified="2013-05-29" version="1">MAPATERTGFGRGKGRGRGHKEEKEDTWVPVTKLGRLVKAGKIRSIEEIYLYSLPIKEYQIVDWFLPKLKDEVLKIMPVQKQTCAGQRTRFKAFVVVGDSNGHVGLGVKCSKEVAIAIRGAIILAKLSVIPVRRGYWGSSLGDPHTVCVKVSGKCSSSMCRLVPAPRGTGIVAAPTPKRLLQFAGIQDCYTSSRGATRTLGNFVKATFIAIGNTYSFLTPNLWKEIPYTATPYEEFSDVLMQTEKVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7PC89</accession>
    <name>M7PC89_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_03534</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875626.1">
        <property type="nucleotide sequence ID" value="XM_007877435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PC89"/>
    <dbReference type="STRING" id="1069680.M7PC89"/>
    <dbReference type="GeneID" id="19897221"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03534"/>
    <dbReference type="eggNOG" id="KOG2164">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011811_0_0_1"/>
    <dbReference type="OMA" id="ASWKQYL"/>
    <dbReference type="OrthoDB" id="302966at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16536">
        <property type="entry name" value="RING-HC_RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039739">
        <property type="entry name" value="MAG2/RNF10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983">
        <property type="entry name" value="RING FINGER 10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="170"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="513" mass="61340" checksum="103AF0FCF78C78C9" modified="2013-05-29" version="1">MDEHIKEPIYYLNGPNNINAKNIKVTKNYNKKVLKDDQKNEKNQSKSICEKQKILSNKIENKKNISLKPGNLKFTNKVEKIPLTHLLNFSYSRSLTSQLTSSNYKNTKKKHIHKNDYRTKNKEYFINANYRFIVSPYEDYRPQMLDPDIPIPWKNILQILVSRLTQHSLCAICLEEDLVASRMTKCGHIFCLPCIIRYFENKNEDDNKDFKWKRCPICFDAICIIDLKPLRWHDNVSPELPVEGKEILLRLFIRKQGNFFSLPWENMSKSIDRNEIPWYFEQDVLDYSRIMKASENYMIKEMKLELKELYRIKDSKKTDMVFTNQSINKAIEHIQQSILSFEKISNDHKHFYETEALTETQINIKELNIEDNILTQTKSFDNKQKNYSYLFYRPQIMTHYYLSILDIKILKMAFGDYTLFPPNIIAKVENISTGHIVDDELRKRTKYLSHLPYGCEVSFLECNWSGVIDESILEKFDYEIKRRQQKKREKIIKEEKDSKKRYFKEKNQADLYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCE5</accession>
    <name>M7PCE5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">ER membrane protein complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_03581</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875675.1">
        <property type="nucleotide sequence ID" value="XM_007877484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCE5"/>
    <dbReference type="STRING" id="1069680.M7PCE5"/>
    <dbReference type="GeneID" id="19897268"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03581"/>
    <dbReference type="eggNOG" id="KOG3318">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098404_2_0_1"/>
    <dbReference type="OMA" id="QQTFKVI"/>
    <dbReference type="OrthoDB" id="369569at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009445">
        <property type="entry name" value="TMEM85/Emc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19315">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06417">
        <property type="entry name" value="EMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017207">
        <property type="entry name" value="UCP017207_TM-p85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="181" mass="20897" checksum="F4AA4031B04964B7" modified="2013-05-29" version="1">METDINTEWVEEFIYAKKRGTLISERKFADPPGYISDEGIQTKALKSSLPTLSTEKTELLKIKKAWEVALAPAKMLPMSIIMAYMSGNSLQIFSLIMTFMLFWNPIKSISNINKVFVHLESPKTHSKLFLPKLLFVLIQLVTIALGLIKMQWMGLLPITRSDWLAWEHERNHLEYSVFSYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCK6</accession>
    <name>M7PCK6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="5">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIF6</name>
        <name evidence="6" type="ORF">PNEG_03365</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <text evidence="5">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875447.1">
        <property type="nucleotide sequence ID" value="XM_007877256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCK6"/>
    <dbReference type="STRING" id="1069680.M7PCK6"/>
    <dbReference type="GeneID" id="19897052"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03365"/>
    <dbReference type="eggNOG" id="KOG3185">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071894_0_0_1"/>
    <dbReference type="OMA" id="WCAFCGM"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="5">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="5">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="245" mass="26057" checksum="F2D7C136937E6AC2" modified="2013-05-29" version="1">MALRAQFESSSEIGVFGKLTNSYALTAIGSSENFHSIIESELGDIIPVCHSSISGARIIGRMTAGNCRGLLVPSTTTDQELMHLRNSLPDSVKIQSINERLSALGNVIACNDYVALVHPDIERETEEIIADVLGVEVFRQTIAGNVLVGTYCALSNQGALVHPKTTIAEQDELSSLLQVPLIAGSVNRGSDLVGAGVIVNDWIAFAGFDTTAIELSAIESIFKLHDAQTATAITGIRNATIETYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCL0</accession>
    <name>M7PCL0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_03369</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875452.1">
        <property type="nucleotide sequence ID" value="XM_007877261.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCL0"/>
    <dbReference type="STRING" id="1069680.M7PCL0"/>
    <dbReference type="GeneID" id="19897056"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03369"/>
    <dbReference type="eggNOG" id="KOG3353">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083987_0_1_1"/>
    <dbReference type="OMA" id="NTYETAR"/>
    <dbReference type="OrthoDB" id="10254664at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_A">
        <property type="entry name" value="Ribosomal_uL22_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057265">
        <property type="entry name" value="Ribosomal_uL22_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_uL22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003260">
        <property type="entry name" value="PRK04223.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF10">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="170" mass="19657" checksum="8D13C2F349C3D791" modified="2013-05-29" version="1">MVRYASEPSNPAKSAKARGEHLPVHFKNTREVAQAIKGLSLTRAFQYLENVKEHKEAVPFRRFHRGLGRTAQGKPFRVTLARWPEKSVRFIVDLLNNAKSNADFKGLDIENLYITHIQVNRAPRQRQRTYRAHGRINPYMNSPCHIEIIVSEETETIKKADDSKAIQRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCT3</accession>
    <name>M7PCT3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872010.1">
        <property type="nucleotide sequence ID" value="XM_007873819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCT3"/>
    <dbReference type="STRING" id="1069680.M7PCT3"/>
    <dbReference type="GeneID" id="19893847"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00149"/>
    <dbReference type="eggNOG" id="KOG1994">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046724_1_0_1"/>
    <dbReference type="OMA" id="DYMNMVI"/>
    <dbReference type="OrthoDB" id="786951at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025239">
        <property type="entry name" value="DUF4187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039249">
        <property type="entry name" value="GPATCH11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032:SF0">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01173">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="70"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="112"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR11715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="283" mass="33867" checksum="810D26DAB117B5AD" modified="2013-05-29" version="1">MDSQDESTLLNEDDDDYLTMALPDLSSSLISTRERKVYAQRERGICKSYQVREHERRKEALSSSLMDFEKPSKAMTMMFKMGYRKGEALGQKQSEGKLEPLEINMKTDRLGIGHKTMQKQKIEQEIQKIRENEIDYESRMRLEREKKYLEAKVLEAQKVCENLDKKESLDEPRKINVLWRGLVVQRIEKEMEKRRRHGIFDRPEDSQDFLSDEIKPPRHTHIEWNEDEDMELYAFNQLDPGIRLEKILDFLRQNYNYCFWCGYAYQNEEELSTYCPGKKEEDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7PD00</accession>
    <name>M7PD00_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_03164</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875227.1">
        <property type="nucleotide sequence ID" value="XM_007877036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PD00"/>
    <dbReference type="STRING" id="1069680.M7PD00"/>
    <dbReference type="GeneID" id="19896851"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03164"/>
    <dbReference type="eggNOG" id="KOG2141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006786_2_1_1"/>
    <dbReference type="OMA" id="CGNERNY"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF4">
        <property type="entry name" value="NUCLEOLAR MIF4G DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="MI" evidence="6">
        <location>
            <begin position="490"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="712" mass="83535" checksum="51794C458520213C" modified="2013-05-29" version="1">MRDKKTKKKGKQGKKEENEDMQMNKTIIKIKNENLSEEDLKKYSGKKREKTINMKYKGCYDAEDDVIEYLEKKLKRKNQNINRKNKKDELDYLLEDLNYIDRKKTKRVKFMEDSSVLCNSEVKNKTNINKEELFIEDKENKSNLDRENGAILVKKNKENPYIAPVGNGISITKNKILKDDKNNNEFTIHLKRKIKGLLNRLTESNMLSILNEIENLYSSNPRHYVNLELITLLLKNITSQTTLKETYLVLHSGFITALYKIIGIDFGAFFLQKLIKTFNEFYSKENSKKENIDTNISYDKECINLIIVLSELYNFQVISCTFVYDLIKLFLKEITDLNTELLLKIILNSGSQLRCDDPSSLKDIIIIIHRKISETDVVLNTRTKFMIESIDNLKNNKIKDIPSIMTREAIVRMKKFLGTLSNRNSNRNFEPLKISLSDIESMDENGKWWHAGSSSRKEEKRKTPISVNSFYEKKETELLTLAQLQRMNTDIRKSIFITLMSGEDFVDAYEKLLKLRLKKVQKLEIPRVLLHCCGNERNYNPYYAYIALRFCVRMSFLRTAFKFCLWDLFRSLGEKDIQVIGNTNTENTENISLRYIVNLGRLYGFLVVNDGLDLAIFKKLNFFHLQSKTKTFLEIFFCTLIQETQKRSNIQSVTSIQKIFEKLSSNPSLIVGIKYFIEKYLKNSEILNSRDKEIFIWDYKKVLEILSIPKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7PD25</accession>
    <name>M7PD25_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RED-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875257.1">
        <property type="nucleotide sequence ID" value="XM_007877066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PD25"/>
    <dbReference type="STRING" id="1069680.M7PD25"/>
    <dbReference type="GeneID" id="19896881"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03194"/>
    <dbReference type="eggNOG" id="KOG2498">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_735999_0_0_1"/>
    <dbReference type="OMA" id="NHEENTH"/>
    <dbReference type="OrthoDB" id="3366823at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039896">
        <property type="entry name" value="Red-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12765">
        <property type="entry name" value="RED PROTEIN IK FACTOR CYTOKINE IK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="50824" checksum="48D6665A03832001" modified="2013-05-29" version="1">MNQDDFRRLLATPQQPRQTTSRPSFFRPISKDSRQTFIEKTTKKFSEKSTHGNRCVGKKAAKNEGSNTTSSLLPEGYRNRAKELQKEDSEDRRAYSMQENMLLNLKEAVKKGEISHQDYLLQTQRLGGDFENSCLVRGLDRVLLERVRRGEEIGISEPTTIQKDSTKAVETKEEALDLDKIYMEGLSKKKDLEENISKRKNRDELLSILKKQKTQDPVKEQSKFKPIGVRGENPKKNESLKKKDDLCCEKKLLNQDQKNEKMTILKETKSTTPIENFPEKIQKTSNEENNDIFDDVGTYDPFESMNFYTDQEQPTQNLIQHNINNTYTPKRNYFHTSTLLEDDNLVEAGSLTRESILKNDVQLVTALKKAATLEHLDNHEENTHIKKKSMNMGFGLWLDDAYNDIDLNDDPFDDDDNLPSKSKRKTKLTDTKRSKVTTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7PD39</accession>
    <name>M7PD39_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phospholipase A-2-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_03209</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat PLAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875272.1">
        <property type="nucleotide sequence ID" value="XM_007877081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PD39"/>
    <dbReference type="STRING" id="1069680.M7PD39"/>
    <dbReference type="GeneID" id="19896896"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03209"/>
    <dbReference type="eggNOG" id="KOG0301">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011791_2_0_1"/>
    <dbReference type="OMA" id="DKCIYYW"/>
    <dbReference type="OrthoDB" id="10265988at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032473">
        <property type="term" value="C:cytoplasmic side of mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140036">
        <property type="term" value="F:ubiquitin-modified protein reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070314">
        <property type="term" value="P:G1 to G0 transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072671">
        <property type="term" value="P:mitochondria-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000175">
        <property type="entry name" value="Phospholipase A-2-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.870">
        <property type="entry name" value="PFU (PLAA family ubiquitin binding), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015155">
        <property type="entry name" value="PFU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038122">
        <property type="entry name" value="PFU_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09070">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51394">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="11"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="102"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="141"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="180"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="PFU" evidence="9">
        <location>
            <begin position="355"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="10">
        <location>
            <begin position="475"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR08369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="754" mass="85765" checksum="2F0B2EACEA6FD5ED" modified="2013-05-29" version="1">MSQFYVLSQSFVGHSQDVKVVCEGSESLIFSASRDGTVRSWNISKESTIKSNIYSMHSGYVNSLAFIKCSEKYPNGLIVSGGQDKLIAVYDPYKYIEPDYVLIGHQGNVCALHATENAMIISGSWDKTAKVWKNWKCLYTLEGHTAAVWTVLIVDENRFLTGSADKTIILWLDGIQVALFKGHTDCVRSICKISDTEFSSCGNDGVIRIWSFSGEQILEMTSGRSFMYSLSMLSTKELISSGEDRSVKIWKDGKCVQTIIHPAVSIWSVTVLKNDDIVTGGSDGIIRIFTRDKERMASEEEIYEFNKSVASYKISTNNLDHINKEKLPGIEALQKEGKKNQVIMIKANNIIEAYQWNISKMAWDKVGEVVDVATPSQKQVYNGQEYDYVFDVDIAEGLPPLKLPYNVNQNPYEVAYQFIQNHQLSIDYLDKIAKFIQENTKRIEIGEQSSFIDPYSTGRYIPGRSCSESSEPSKKILPHTSFLSFKQINIFGSIQKCMEFNSIFEKSEHKNISLNPEEVLTLETIAECLKDPKGKFPAKNMVLDSLDLIVKLANIWPYDKRFPGLDMLRIFCERFEETSSYKYGVKSIIDIIIEGGLSNDSLAFSEKIIGNNIMLSLKALVNLFEKDSGRKILYQNLEKIKTKIFNIYNILFDRNIKIALSTLYLNFSILFYQQSSAQNAINFIEPIFQILSEDNDSECIYRTLVALGTILYTLKKSKYIYIDRIEMITQKCKNNFKELRIVSLINEISEILHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7PDC5</accession>
    <name>M7PDC5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_03288</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875362.1">
        <property type="nucleotide sequence ID" value="XM_007877171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PDC5"/>
    <dbReference type="STRING" id="1069680.M7PDC5"/>
    <dbReference type="GeneID" id="19896975"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03288"/>
    <dbReference type="eggNOG" id="KOG2140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RSYETRY"/>
    <dbReference type="OrthoDB" id="3938623at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000004">
        <property type="entry name" value="pre-mRNA-splicing factor CWC22 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="7">
        <location>
            <begin position="409"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="632"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="651"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="674"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="694"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="723"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="735"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="764"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="776"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="797"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="847"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="876"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="888"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="917"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="929"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="946" mass="110105" checksum="090F494C335AB124" modified="2013-05-29" version="1">MNDVENDANLDTNTFIQSQSKRKSSHVFSPNSLKKKISAPWKSSFSNVHDDDTNGKSDKGYQMNEGIAVTKFSEPELKLAFDPKAEFERLMNTRAGGIYVPPARLKALQSQFTDKESKEYQRIYWEALKKSINGLINKVNTLNIKNIVIELFGENLIRGRGLYCRSIMKAQAVSLPFTPIYSSLTAVINTKLPSIGELLLTRLIVQFRKAYKRNDKFFCLSSTTFIAHLINHQVAQELVALEILALLLERPSNDAVEVAVGFMREVGAFLADVSPRGSNAVFERFRAILHEGAIEKRVQYMIEVLFQVRRDKYKDNPIIPEGLDLVEDGDQITHMLSLNDELDVQEGLGIFKYDPQWQENEDQYKKIKDEILGEDSDESQDNESSSESVEQSGDDKITIKDETNQALINLRRTIYLTIMSSVNFEECAHKLMKINIVEGQEIEMCNMIIECCSQERTYSRFYGLIGERFCKINRFWTENFEQTFLNYYDIIHRYETNRLRNIATFFGHLLSSDAISWHVMRCIHLNEDETTSSSRIFVKILFQELMGVLGIRELDERLKDPLLQETLSNMFPRDNPKNTRFAINYFTSIGLGLITVSLREHLETIKNTVTVNRSLSKSSSSSIISSYTTSYSSESLSYPNDTSESESLNRSRSRHRSPARHRMRSPRDNRSRPRSCSLNRSRLQSSESESLNRSRSRHRSPARHRMRSPRDNHSRPRSRSLNRSKLQSSESLNRSRSRHRSPARHRMRSPRDNHSRPRSRSLNRSKLQSSESLNRSRSRHRSPARHRMRSPQDNRSRLHLRSLNRSRSRHRSPARHRMRSPHDNRSRPRSRSLNRSKLQSSESLNRSRSRHRSPARHRMRSPQDNHSRPRSRSLNRSKLQSSESLNRSRSRHRSPARHRMRSPQDNHSRPRSRSLNRSKLQSSESLNRSRSRHRSPVRHRMRSPHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M7PED6</accession>
    <name>M7PED6_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_02986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875034.1">
        <property type="nucleotide sequence ID" value="XM_007876843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PED6"/>
    <dbReference type="GeneID" id="19896673"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02986"/>
    <dbReference type="HOGENOM" id="CLU_2016214_0_0_1"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="123" mass="14521" checksum="4CB1EDDD22153C13" modified="2013-05-29" version="1">MPKEQGSQGWIFNELLHLDNIDFCFSDYIPSYERVVFLLETIQKTYLDYSDLLKSAFISEYNTQHIIDSSDPLHPNNCLLYISSSTKPGYWMQRNIGMDQNINLSLYREHLCRYFGKTKLSCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7PEH4</accession>
    <name>M7PEH4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit M</fullName>
            <shortName evidence="5">eIF3m</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02649</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit M family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874670.1">
        <property type="nucleotide sequence ID" value="XM_007876479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PEH4"/>
    <dbReference type="STRING" id="1069680.M7PEH4"/>
    <dbReference type="GeneID" id="19896340"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02649"/>
    <dbReference type="eggNOG" id="KOG2753">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035254_0_1_1"/>
    <dbReference type="OMA" id="VCLKALW"/>
    <dbReference type="OrthoDB" id="10267031at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03012">
        <property type="entry name" value="eIF3m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027528">
        <property type="entry name" value="eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040750">
        <property type="entry name" value="eIF3m_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF2">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18005">
        <property type="entry name" value="eIF3m_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="185"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="405" mass="46019" checksum="BAECFD4378F92AE6" modified="2013-05-29" version="1">MGEINTLIVEGTFAYKLEEIASFIDTLNEETGKDSLVSELEGISVEENKDLCLEILVNESHVLSRCNEKDYRAAWNLFIYLIQESSSIERLLPKVLSNLVIPNFPNGPLYLLSTLSVLFNTLPSNSILKYDVFCVILRVANEQKLFDFILSQIKDISEWLTEWGVDNNAKRDLFLVISGYALEYDKKISLDFIIKALWTYSPLEMASASDLARQAIISSISHPKQYQFDDIAAIDAVQFLKNINDPSFYLLEIFMVGTLKDYLSFLNTHRQWVENSGLDQDVALKKIHHLTLISLAASSSSRVLSYSEIANVLNIDISEVEMYVIDTIRMGLLEGRLSQLSKTFLIHRNTYRVLGKEQWMDLKSKLNAWESNLEGILKVIKQNKTKVSANEDELAYLSSSVGIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7PEQ1</accession>
    <name>M7PEQ1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PNEG_02724</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HRD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874750.1">
        <property type="nucleotide sequence ID" value="XM_007876559.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PEQ1"/>
    <dbReference type="STRING" id="1069680.M7PEQ1"/>
    <dbReference type="GeneID" id="19896415"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02724"/>
    <dbReference type="eggNOG" id="KOG0802">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009169_3_1_1"/>
    <dbReference type="OMA" id="QENALMA"/>
    <dbReference type="OrthoDB" id="7759664at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16479">
        <property type="entry name" value="RING-H2_synoviolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057992">
        <property type="entry name" value="TPR_SYVN1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058051">
        <property type="entry name" value="Znf_RING_synoviolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF184">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SYNOVIOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25563">
        <property type="entry name" value="TPR_SYVN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="290"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="560"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="389"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="450"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMR08944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="585" mass="67977" checksum="532819B888C87A18" modified="2013-05-29" version="1">MKLVIYGTSSTIATAFVILSAFLNRSNFYAACIYLTENSACLIVLMNMGLFLTAIIGKGIQRIFFGPLRAIEIEHLYERAWYSITETCLAMTIFRNNFDTRSIIVLVTLIFLKTFHWLCFDRLEFTRQSESILLRQHVRIVVSIVFLLIIDILMTKFSINTVLHEKPSMMLMFAFEFAILTSTIIGAGIKYIFNLIDSYQDNWENKALYILYLELFMELFKLIAYSIFFILALTFYGLPLHIIRDIYMTFKSFLAKCRDLIRYKRVTNNMNQRFIDATFEEIAATEDKTCIICREEMVHSSIKKLDKNNKSQSRINSTPKKLPCNHILHFNCLKNWLERQQSCPTCRQSVLEDQSREIFNINRTQIFDFLRNLARRNVEAPNRNQETRQNNNPVPQNPANYQNPQNTPIFPNNYRFYSDWTVIPLINQNIHSIHNIINNDNSDTSFSNNAENTNKNKQTDSNSSSEINKGKNYKAFCLNNVDSNFQSAFPERLDIINFKTQAPSNTIYTRDSNLTKVDSTLFDADSIKKIEESNKLLLQAQEKISQSLQILKTQELQKNIESKSPSNTDEIDKKLNKNASLMENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M7PF10</accession>
    <name>M7PF10_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Borealin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874855.1">
        <property type="nucleotide sequence ID" value="XM_007876664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PF10"/>
    <dbReference type="GeneID" id="19896510"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02821"/>
    <dbReference type="HOGENOM" id="CLU_2455665_0_0_1"/>
    <dbReference type="OrthoDB" id="2392550at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018851">
        <property type="entry name" value="Borealin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10444">
        <property type="entry name" value="Nbl1_Borealin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Borealin N-terminal" evidence="1">
        <location>
            <begin position="20"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="89" mass="10774" checksum="96BCDFF7B3D0AA47" modified="2013-05-29" version="1">MELESPQKTAISDVHLKQFKKEELLRNLDFELKQRLEQIESYFLLLRNTLQLCGEMRLSRVPRAIRNTKLRDYYKQHNIENKENKPESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7PFV4</accession>
    <name>M7PFV4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kinetochore protein Sos7 coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874278.1">
        <property type="nucleotide sequence ID" value="XM_007876087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PFV4"/>
    <dbReference type="STRING" id="1069680.M7PFV4"/>
    <dbReference type="GeneID" id="19895977"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02284"/>
    <dbReference type="eggNOG" id="ENOG502S6XI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_739920_0_0_1"/>
    <dbReference type="OrthoDB" id="18959at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037475">
        <property type="entry name" value="Sos7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048781">
        <property type="entry name" value="Sos7_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329:SF1">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20882">
        <property type="entry name" value="Sos7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Sos7 coiled-coil" evidence="2">
        <location>
            <begin position="97"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="132"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="374" mass="43704" checksum="4005DADB3F6F6F53" modified="2013-05-29" version="1">MATIVVKQMVNLTNAFKESKENNMDLLNIQKAISSFISTKLFIHSQKQDYIRKTNSAITTSSQQSDLDKISNLQIMEINENVPSPNMVESDLKYFKELFSKLKFSYIEQETKERYLRAILDDPILVIENKDNLELEKKNMELKSLLKNTKESLNATCQNLEQTISKVCNEYEIMIQQALEASDMLKEIEKMEAEIEELKDNEQNAEQNLSLKDSLSLLSSQTAKSIKLKKDIKNYQTIYQHKKKQLEEATEEIRKSENEKQSCETFAKEALHTRNTFSTDNRYKKEQTCLWYQSLLDLQTSLFEIKNLKQDNTKEHIYFTLKTHTGDINIHICFKDGRFHDIYTDPPVHTKDILMEAKKRNDPLFLINNILSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7PFV7</accession>
    <name>M7PFV7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CENP-T/Histone H4 histone fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02289</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-T/CNN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874283.1">
        <property type="nucleotide sequence ID" value="XM_007876092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PFV7"/>
    <dbReference type="STRING" id="1069680.M7PFV7"/>
    <dbReference type="GeneID" id="19895982"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02289"/>
    <dbReference type="eggNOG" id="ENOG502S8G5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024001_1_0_1"/>
    <dbReference type="OrthoDB" id="10071681at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22920">
        <property type="entry name" value="HFD_CENP-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028255">
        <property type="entry name" value="CENP-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46904">
        <property type="entry name" value="CENTROMERE PROTEIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46904:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="7">
        <location>
            <begin position="305"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="375" mass="42747" checksum="6B1A2812BA11B7F6" modified="2013-05-29" version="1">MDESSETPYTSLRQLSSILANQSNKSSSVLKTAFSARKTPISRERYGPRTGQTPHSITKNPPTPYTARALQKAATPHLHLKKKNEHQTFHDTPRDILRKLSRALPSYLEKNRTNDYGLEDEFRNMYDIENIEESEENMEAPNINIPSSEDVSEDFSPPHLSIPLDQEHTVQSIELGRRANIKRLSDRLSLEKDSEHISIYNEQEANSTSFNEFTLHDDGLLKSESFFREEDLKMRFYRNDTIEDDSTNLEISFLTEKSPMITETASFKDTLPEFLLPESTKPSIKQTSKTSVSSKKSKIQKVSRHGIPLPSLPMAFIRQLAANFTTLKISKDALKIICSASDQFFEQISEDLDTFAAHAGRKTIEDSDVIQLMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7PH02</accession>
    <name>M7PH02_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fimbrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01919</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873895.1">
        <property type="nucleotide sequence ID" value="XM_007875704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PH02"/>
    <dbReference type="STRING" id="1069680.M7PH02"/>
    <dbReference type="GeneID" id="19895613"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01919"/>
    <dbReference type="eggNOG" id="KOG0046">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015284_3_0_1"/>
    <dbReference type="OMA" id="WQLMRKN"/>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099079">
        <property type="term" value="C:actin body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120106">
        <property type="term" value="C:mitotic actomyosin contractile ring, distal actin filament layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044837">
        <property type="term" value="P:actomyosin contractile ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070649">
        <property type="term" value="P:formin-nucleated actin cable assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21294">
        <property type="entry name" value="CH_FIMB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21300">
        <property type="entry name" value="CH_FIMB_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21303">
        <property type="entry name" value="CH_FIMB_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000042">
        <property type="entry name" value="Fimbrin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000010">
        <property type="entry name" value="Plastin-3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000016">
        <property type="entry name" value="Probable fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000027">
        <property type="entry name" value="Probable fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF18">
        <property type="entry name" value="FI19014P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="115"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="263"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="386"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="508"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="615" mass="70012" checksum="45DC3012430B3237" modified="2013-05-29" version="1">MNIEKLQFKFPNLSQENLFGLINDFKKLDIDGKGYVDKHTIVKAVEYYGERKSYDEVRATLKECHLDSSGRVEVEDYIEEMTKLREGRNRGAFEVNKNRITVQGSSANVTHTINEDERKEFTRHINLVLGQDEDMRDRLPFPEDTMQIFDECRDGLVLSKLINDSVMDTIDERVLNKPSHGRPINNFQMTENNNIVINSAKAIGCSVVNIGAQDLIDGKEHLILGLIWQIIRKGLLSKIDIKLHPELYRLLEEDETLEQFLRLPPEQILLRWFNFHLNTAKWDRRVTNFSSDVSDGENYIILLNQLKPNECTRDSLKTMDLLKRAEEILQSAEKIGCRKYLTPAALVSGNPKLNLAFVAHLFNTYPGLEPLGEEFPKIEDYDAEGEREARVFTLWLNSLDVDPVVVDLFEDLKNGLVLLQAYDKVIKNSVNWRRVSKPKDGIELSRFKCVENANYAVELGKGCGYSLVGIQGADIVDGSKTLTLALVWQLMRQNIIQTLSSLSKDGKEITDSDMVLWCNQMSRKGGKTSTIKNFKDPCLRNGIFLLDVLNGLRSDYVDYNLVTSGVSYEDAFLNAKLAISIARKYGALIFLVPEDIVDVRSRLILTFIGSLMALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7PIW5</accession>
    <name>M7PIW5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptidase M16 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_01105</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873020.1">
        <property type="nucleotide sequence ID" value="XM_007874829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PIW5"/>
    <dbReference type="STRING" id="1069680.M7PIW5"/>
    <dbReference type="GeneID" id="19894802"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01105"/>
    <dbReference type="eggNOG" id="KOG0959">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004639_1_1_1"/>
    <dbReference type="OMA" id="WHEPNEY"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082921" description="Peptidase M16 N-terminal domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="8">
        <location>
            <begin position="70"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="9">
        <location>
            <begin position="234"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="10">
        <location>
            <begin position="415"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="11">
        <location>
            <begin position="804"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR10389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1066" mass="125011" checksum="CC183CDD634CBAC3" modified="2013-05-29" version="1">MKLTSLLLLSLTLITKYTKSNEFRDLNNAAKDPNSNYNPSHVEIIEKDFEKSTLDDSEYRVVKLQNGIEVALVSDPSVRLAATSVAVRVGSKDDPKGFPGLAHLCEYLLFMGTEKYPLENEYTSFVLNHGGSFDSYRGLERTVFISEINPKYHYEQLDRMANFFIKPLFREDLIERETHFINSEFEEYRSSFSKARFHFLNYILKDTGLFPEFTTGNRQTLFSEPRAKNMSVKKALEDFFDNYYHSRDIKVAVCGNESLDTLQELVQKTFGQIPDKKERAIDDVNPFSSITKYHYWYNFSGAPYTADIAFIVPSSRVHYKSVPFHYLNYIFSYSGPDSPIDYFSKKSLASRIRFSNIEYSSKYDLLFVSLKPLYVGRLFYEELILEFFKCIQFFKENGPNKAVFEDIMKAQNTNFKYSFKESVSQLVDKLSTSLLADSFPRKYLLKQDIIKEYNKEEFDEFFSALNYENFISFSNTIRKGYNETDPYYNITYLKQSHKKRFIEKLKNISSPNLKYPPKNIYLDESDITMEKLNETLTKPDLLKDTYVSTLWHKHASFFYCPYGVIRILLKNPFVSSTPSNMLKIRFLQIYIYSSLPFDFLLLSTANVNFYITPTLHGLIIMFYGYTNKMMELVTRVINTLKETSLDHRLFNPLRSTLIYSYIQRISAEPSTFLEIDIDDILFSERQPFKNMLFVLDQFQHSDVNAFFYNLLNNFHFDVLITGNIPKEDALHIHNMLETTFSPHPLTSSQRHYINTRAITLEDGSDYFRVHELSKSGPKSALFMYFEAAEMEDSRRVMLFLILYLILREPIYHELKTKEQLGHIIKSDIKVSRNILGYYILVQSERQPHVLHSRIDAFLNRMLDRILNLTSKELNYHLESLQYFLKKDPSNILSENLNVWSSVVNAPYTSNSDFEPQKADPIEPHELVNLFKEVFYSKRKRFSYTVTSTVTSDIYNLYDLPLDKLSEYLSSKGENVSKEELYNYVLLSHDFPSFRIKLSEHLSKNRNQSDVKSILDETIKYLKRLYLLEKYRILKPLSLVDNIAYFKASLELSPAFVYNSLSSEYHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJG8</accession>
    <name>M7PJG8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Origin recognition complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_01312</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873238.1">
        <property type="nucleotide sequence ID" value="XM_007875047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJG8"/>
    <dbReference type="STRING" id="1069680.M7PJG8"/>
    <dbReference type="GeneID" id="19895009"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01312"/>
    <dbReference type="eggNOG" id="KOG2538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015257_1_0_1"/>
    <dbReference type="OMA" id="YCLMEHY"/>
    <dbReference type="OrthoDB" id="10265211at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20704">
        <property type="entry name" value="Orc3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020795">
        <property type="entry name" value="ORC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045663">
        <property type="entry name" value="ORC3_ins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045667">
        <property type="entry name" value="ORC3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040855">
        <property type="entry name" value="ORC_WH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19675">
        <property type="entry name" value="ORC3_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07034">
        <property type="entry name" value="ORC3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18137">
        <property type="entry name" value="WHD_ORC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 3 N-terminal" evidence="10">
        <location>
            <begin position="56"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 3 insertion" evidence="12">
        <location>
            <begin position="379"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 3 winged helix C-terminal" evidence="11">
        <location>
            <begin position="612"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR10609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="726" mass="85372" checksum="EEC564689C862692" modified="2013-05-29" version="1">MGDDVVTEACYMFLPKDIESKKNHIFNKTQDELTSKCQQIYSDIEMHITDMQHKYKQEEFLKYSESYFPCLMHGRETELSRNYRYMCFRLQSNQLKNDINELLETIHDNMVASLSVFIEQNKLWKDENKIPTCILLLGAYFFDHIGLYACIEAQLKANIYGPFISLHVRRTPDMKACFKQIIETCIQFGQQTNLNISTEKNPEERELDIYCDYDPECVARWYEEAIFRGLINQDQFRLVIFLQEVEGFDGNFFNHFITILKKMHKRVPLLLFIGISTSVEIFQDILEKKSLKALNIKYFNTKHSNYSPDIAIEKILVSSKHPKLRLGPHLYYTLFDMYQKHSFNIASFLSAIKFATMSHFFSNPISIVNHCNSAHSELISHDHLECLRSLPSIKRYIEDLLDKGDIYSAESLLNDDYYFRNIINTLIHDIEEHNKKLDAFIFFLNIIQGKYASSVRKKSLSWIYGKLLENDIQRNLDTILNPIKIMNSISILQFIQEALALKDIHDQFPDLEDFYRRISDIVELSEDKNLIHISNNETNSCSKTEEISNKAYSELNDKVIGSEFYNIRNSLYEYLQEIFRKYFISPMTYPLHELYYFNYSRAYLDAFHPRIRAAIDTALSLPSHYLSCNYEAGDKENENSLTISSLPKICISYRLFLESGFLINVSDWLTAFIQSASKENNKDDKQDSEEYLQAEFLQSLEELRYLGFIKSTKRKTDHVAKISWMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>M7PKI5</accession>
    <name>M7PKI5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="20">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PNEG_00572</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Membrane</location>
            <topology evidence="20">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="20"/>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR10969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872467.1">
        <property type="nucleotide sequence ID" value="XM_007874276.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7PKI5"/>
    <dbReference type="GeneID" id="19894270"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00572"/>
    <dbReference type="eggNOG" id="KOG0206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000846_5_2_1"/>
    <dbReference type="OMA" id="QALRCGR"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090556">
        <property type="term" value="F:phosphatidylserine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000087">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000130">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF180">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 19 20" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 20" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="491"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1061"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1092"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1143"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1184"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1209"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1250"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="21">
        <location>
            <begin position="71"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="22">
        <location>
            <begin position="1029"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="17">
        <location>
            <position position="563"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="563"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
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        <location>
            <position position="563"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
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        </ligand>
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            <position position="564"/>
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        </ligand>
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            <position position="737"/>
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            <name>ATP</name>
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        </ligand>
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        <location>
            <position position="760"/>
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            <name>ATP</name>
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            <position position="792"/>
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            <name>ATP</name>
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        </ligand>
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            <name>ATP</name>
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            <name>ATP</name>
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        </ligand>
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            <position position="977"/>
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            <name>ATP</name>
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        </ligand>
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        <location>
            <position position="983"/>
        </location>
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            <name>ATP</name>
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            <position position="1003"/>
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            <name>Mg(2+)</name>
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        </ligand>
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            <name>Mg(2+)</name>
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        </ligand>
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            <dbReference type="ARBA" id="ARBA00001946"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00004477"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022448"/>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00034036"/>
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            <dbReference type="ARBA" id="ARBA00049128"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00051303"/>
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    </evidence>
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            <dbReference type="PIRSR" id="PIRSR606539-1"/>
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    </evidence>
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            <dbReference type="PIRSR" id="PIRSR606539-2"/>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
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        <source>
            <dbReference type="RuleBase" id="RU362033"/>
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    </evidence>
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            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF16212"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMR10969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1325" mass="152322" checksum="BB96FCD629C78864" modified="2013-05-29" version="1">MITMLWSALHNFKNKSSKSILKHLDSGLRNNFSTNQVNNIAENEQTFKTRRIFVNLSLTEDMQDEYGLPIESYPRNKIRTAKYTPLSFIPKNLFYQFHNVANIYFFIIVILQNFSIFGTKNPGLSVVPLIVIIVVTAIKDGIEDWRRTVLDNELNNTRTYMLHNWHNNNVVDENISLWRRLKKATSRIIRIIMARRKGIKEDPLSLDYMSSYRISAESRRRSVESRRLSCEKNLDPYSMMQLPSLDCKLSSEFMNARRNIEIASKQETGTILDHYKQTPGKACFKQTFWKNIRVGDFVRLRGDDLIPADILILATSEPDGACYVETKNLDGETNLKLRHALRCGYEIKTAADCEKATFIIESENPNSNLYKYNAIIRWTQFVDENLEEQKGFSEQASIHNTLFRGCQLKNTKWVIGVVIFTGEETKIMLNAGATPSKRSKIAKNLNWTIMVNFIILFCMCFISGVMSGTSWKNKGTSARFFEFGSLGGKPLLDSIIAFVTCLILFQNLVPISLYISIEIVKTAQAFFIYSDVEMYYDKIDYPCTPKNWNISDDLGQIKYIFSDKTGTLTQNIMEFKKCTINGVSYGDTYTKISSEMQKQGMSANEADIKAKASIFNKKIAMISNLRKINNNPYLDESKLTFISTDFVSDLKTSDIEGQAIACHNFMLALSLCHSVIAEVIPDTKHRLEYKAQSPDEATLVATARDMGYVMTARRKTSINLNIHGKEEIYKILNILEFSSFRKRMSIIVRAPNNEIYLFCKGADSTVLPLTNDSKLKNKTTSDLKEFAKEGFRTLVVARRKLSEQEYASWNKQYVVASSAIEDREEKIDQTFGEIECNLELLGGTAIEDKLQDGVPETISLLAEAGIKIWILTGDKVETAINIGFSCNLLSNNMEILTLASGHYETEKIDQIIQKYLKKYINFNETDRKNTFTEDYNHLSLAYALVIDGDTLKILLEKHLKDKFLLLCTQCKAVLCCRVSPSQKAAVVSIIKKGLNVMTLSIGDGANDVAMIQEAHVGVGIAGEEGRQAVMSADYAIGQFRFLSKLLLVHGRWSYRRLSGMIANFFYKNIVWTFSLFWYQIYNNFNGGYLFDYTYILLYNLAFTSLIIILMGAFDQDVDAEISMKVPQLYRRGILQLDWSMKRFWIYILNGFYQSIVCFYFPYFLFYKGTFVTLTGINLNGIEDIGVFIAAPVIMVVNITFLMNQQQWDWLFMLIWIFSVFLFWLWTIIYSQFTITLEFYKIAEHVLSTPSFWIVFLLTIAVSIFPQFTIKSVQKIFYPDDIDIIREQRHLNMFEIKDTTDSNDISINFDQYTEKTMEQYSEKKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7PLI6</accession>
    <name>M7PLI6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA polymerase II transcription factor B subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_00333</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TFB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872206.1">
        <property type="nucleotide sequence ID" value="XM_007874015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PLI6"/>
    <dbReference type="STRING" id="1069680.M7PLI6"/>
    <dbReference type="GeneID" id="19894031"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00333"/>
    <dbReference type="eggNOG" id="KOG3471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027280_4_0_1"/>
    <dbReference type="OMA" id="KGFIIIE"/>
    <dbReference type="OrthoDB" id="364513at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040662">
        <property type="entry name" value="Tfb2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004598">
        <property type="entry name" value="TFIIH_p52/Tfb2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00625">
        <property type="entry name" value="tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152">
        <property type="entry name" value="TFIIH, POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03849">
        <property type="entry name" value="Tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18307">
        <property type="entry name" value="Tfb2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor Tfb2 C-terminal" evidence="10">
        <location>
            <begin position="385"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR11304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="457" mass="53121" checksum="AE84CD7911A2D32D" modified="2013-05-29" version="1">MTFKDNINDYLYQLPKTTLLRLYKNPSACLSIFRLLPNLAKQFILSLLYYPEPLSLEKFDQLVNEDSKSKQAEALDKLYKLHIFQKKEDHLYFTDNFKKQFQILLIGGKSYDTFGILCLIPDKRNIDIAFLDNYARKKWETILHFMLGTGIEKLPGDHILSLLHYSQLMSGSKHDNMKITNSGFQFLLQDINSQIWTLLLQYLNMTEDSKIDPVDVLQFLFMLGNLELGKSYLVSSLTPIQINTLENLKDYGIVYRRKSSRRFYPTRLATILTSNTEVFSSNSDIKNLLHPNHNSKSADKGFIILETNYRLYAYTNSPIQIAVLNLFVHLQLRFSNLVVGIVTRNSVRQAFMNGITAEQIISYLTSYAHPQMKKNTPIIPSTITDQIQLWEMERNRLKATEGYLFRDFNSNTDFELVLKYANELNVVVWEAPLKGIFFVNIQSSNMIVDYIKRKLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7PLM4</accession>
    <name>M7PLM4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00378</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NFYB/HAP3 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872251.1">
        <property type="nucleotide sequence ID" value="XM_007874060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PLM4"/>
    <dbReference type="STRING" id="1069680.M7PLM4"/>
    <dbReference type="GeneID" id="19894076"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00378"/>
    <dbReference type="eggNOG" id="KOG0869">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066247_12_2_1"/>
    <dbReference type="OMA" id="HLHKYRE"/>
    <dbReference type="OrthoDB" id="386949at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22907">
        <property type="entry name" value="HFD_NFYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027113">
        <property type="entry name" value="Transc_fact_NFYB/HAP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003956">
        <property type="entry name" value="Transcrpt_fac_NFYB/HAP3_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064">
        <property type="entry name" value="CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064:SF9">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00615">
        <property type="entry name" value="CCAATSUBUNTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00685">
        <property type="entry name" value="NFYB_HAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="5">
        <location>
            <begin position="18"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR11349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="118" mass="13648" checksum="F6DB7D39EE32F4F9" modified="2013-05-29" version="1">MEEIIENEDSEISYQNLLPVASILRIMKTTLPKNTKIAHKARECMQECVSEFISFITSEASEKCLQEKRKTLNGEDILSAMITLGFENYAEPLKIYLSKYRQMLKANREGTIPYYSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7PM71</accession>
    <name>M7PM71_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chromatin associated protein KTI12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00013</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the KTI12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871864.1">
        <property type="nucleotide sequence ID" value="XM_007873673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PM71"/>
    <dbReference type="STRING" id="1069680.M7PM71"/>
    <dbReference type="GeneID" id="19893711"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00013"/>
    <dbReference type="eggNOG" id="KOG3062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027147_1_1_1"/>
    <dbReference type="OrthoDB" id="9972657at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013641">
        <property type="entry name" value="KTI12/PSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12435">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08433">
        <property type="entry name" value="KTI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR11569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="24608" checksum="16CF34AD8C3DDA98" modified="2013-05-29" version="1">MYSAVGRALNKNTIVLCDGMNYIKGYRYQLYCEAKNSGTSYCVIHCGTPIDICRKWNYTRKSLGYPQDIFEELLMRYEEPNSSTKWDSPLFTVIYSDLSFPVDSIWKILSSTKMIKPNASTLVKPLSSSDYLFELNKITQEIINTIIENQTINDSKSEIKIDSINQSIILPNNVTLSKLQSIRHQFINLNRIQTSSKSKIQEIFIEFLNNQFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7PMC7</accession>
    <name>M7PMC7_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00068</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871924.1">
        <property type="nucleotide sequence ID" value="XM_007873733.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7PMC7"/>
    <dbReference type="GeneID" id="19893766"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00068"/>
    <dbReference type="eggNOG" id="ENOG502QQFV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001029_0_0_1"/>
    <dbReference type="OMA" id="HSWKFFA"/>
    <dbReference type="OrthoDB" id="102511at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044840">
        <property type="entry name" value="Nup188"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041634">
        <property type="entry name" value="Nup188_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048883">
        <property type="entry name" value="Nup188_N-subdom_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431:SF1">
        <property type="entry name" value="NUCLEOPORIN NUP188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431">
        <property type="entry name" value="NUCLEOPORIN NUP188 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18378">
        <property type="entry name" value="Nup188_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21093">
        <property type="entry name" value="Nup188_N-subdom_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal subdomain III" evidence="9">
        <location>
            <begin position="544"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="domain" description="Nuclear pore protein Nup188 C-terminal" evidence="8">
        <location>
            <begin position="1250"/>
            <end position="1595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1595" mass="185237" checksum="3769F90F91B3E373" modified="2013-05-29" version="1">MSSFDNHDCNIDGFLITFKSFIDLVEDSLISLPVEILKETFIKRINNINKYLNDKKYVSKESEYNLLEDFLDVYGEFTSLIKNHEKVGHYAKILNISTSNCSKIIFIAQKLFFISIQEINLEYIINTYMSEKRYMIRFIMNIFRLSSDEKHPYYEIFNILVLEFQKDENFMRNLIEMIETIQKYTPPSYSLDEFNLTSWLRNVLKKQFELLKLVFISIYYKMPCTLEMAVSWFKLMKEFHYLLNKRKIYSINNEVNLLQRIVSLSLIISIEIIRPSRNLNFLNENLHDNTFYSSPDAFLEVHNMIVKLVEDPVWSPVIIAWGIILHELFIDITERQDFSKEYHSIQDQIFPNNSFESSKYLIEISLKYNVLSMIGNMISSFSPDEDLCIDTYRMVLRELFRKILNYVKFSDSVVNCFIKIHENISSDSNLAYLFWSDDIIVRLLHSARTRFPYDFFSMIRICRSVSSDSKSTYDFLKNIPTFTQITPVGFKGYDILEEDFNGTLVKLIDDLKIFSAKISDNSNDIIIPKYSLGRIISYDISPPVIMWDYCYSSWEFLGKILEISLTDRLFIKNEKIIIEIILIMTNILKSNDDLGKQLITDISSDLMDQSDIIGIVREICSLSLQLNEAPEFVRLNLISASIDFFSEVIRSSSKNWSHIFKLNLLDKNENSGLLYNIFSSEIVLANYSIQISFLKLLRVLLENYISITDCQHNFQAFQADYITRAFKYTYELFESFIEWRYTYLSQKYDIGLIITSLFLRILEFTYDLDYRYQNSPIMNSIKPLAQFILDKFLSQNSDSRCLHTLWKVFKDKHITNAYNQWVKKTINFIDCLIRIRNWMKSPLSALEKQLFQRLPSILSFMQFSKQYYIPILQLITNMISSSSQRLPSLLAYLSNYTSIFIENLKYIISNPIIDQNIKTHVWKFSSAVMKFQQGLAILLLTGNSSFQQNAQSKQENSNSSLFKLAILELYKINDVYSILNSEYLASFLEFIANAQNCWVSVVPLKFKDDKFWSKILTLIDWISTLKSNFSTNLSSICYQIAGIAFSVQICTAEIYLQSQTQSTILKSGFEKSLLNKLDSYSKFVLNISGYRVSLHSNLKKNFEKTYSDKSLFCFRNSGIIKSPSYGDEYFYNLHITNIILGNNKVSLAYLNEMKEANLNLSLLDAQVTLLRAWIFLCSSIFHPKSLEIENLKTYVNIIITALKANSKENIDLSIMMPIAHERAELSLFLTMHLQAIKSKFHLGSYFSTILLYAWEAISSSEANFLLSIGTKNSQYTRTLLRIIYICLHGINSSEDNVENHTMFPILIGLSDLVLARGASKLFSKALETQNSVFPSDIMLFAAIAEEIFDIQGIEALYDTITTSMFQHDNFHSIITFFSNIDTIKENQDNYLFAEASLLFLYTLSSIPSLSEQLVVYGLLNILVDASICHEVQEKVINIQNSNTGSISLSLYQLWVRGILPIVVNLLRHLGNRIFVEICGFLKIYDVQIQTAFENWNRPTVITSLVIEETFLLVMIFDILHMEGNNNNDYLFNKTELLDSITYLLSHPKYLATLIIPVTEMDHLMAAKLSDDNETVPSTKFINYISEKLEGLRNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7PMD8</accession>
    <name>M7PMD8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00078</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871934.1">
        <property type="nucleotide sequence ID" value="XM_007873743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PMD8"/>
    <dbReference type="STRING" id="1069680.M7PMD8"/>
    <dbReference type="GeneID" id="19893776"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00078"/>
    <dbReference type="eggNOG" id="KOG3298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085878_2_0_1"/>
    <dbReference type="OMA" id="TMRQPGL"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990328">
        <property type="term" value="C:RPB4-RPB7 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010590">
        <property type="term" value="P:regulation of septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04462">
        <property type="entry name" value="S1_RNAPII_Rpb7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000043">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="8">
        <location>
            <begin position="9"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="81"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="171" mass="18886" checksum="0AFD13112D5A21F8" modified="2013-05-29" version="1">MFFLKDLTLRITLHPSFFGPRMRDYLKAKLLSDVEGTCSGNYGYIICVLDSNKIDIGKGRIVPGKGEAEFQVGYKAIVWRPFKGEVLDAVVSTVNKMGFFADVGPLSIFVSSHLIPSDLKFDPTSNPPSYVSEDQLVEKGAKVRLKIVGTRNDATEIFAIGTIKEDYLGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZX02</accession>
    <name>A0A0W4ZX02_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_04297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="KTW32893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613367.1">
        <property type="nucleotide sequence ID" value="XM_019757816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZX02"/>
    <dbReference type="GeneID" id="30671583"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04297"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KTW32893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="88" mass="10716" checksum="AD78303A9BAEF62D" modified="2016-03-16" version="1">MLYILLIHEGNRYRLEKLRNVIFWLIDSYFKYKSIDAIIADIPLRDIIRIYINMYRMSALDFQSILYRNASQIPGKGIYYSRGYNRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZX39</accession>
    <name>A0A0W4ZX39_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_04259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="KTW32937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613405.1">
        <property type="nucleotide sequence ID" value="XM_019757782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZX39"/>
    <dbReference type="GeneID" id="30671556"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04259"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KTW32937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="91" mass="10965" checksum="5D26FAD1CA71E111" modified="2016-03-16" version="1">MFFYQFISVEILIELFKLLNFYNINQIYHLNLWNINQSLKLLKSESIVFDMDFALIEHEIEDDLYLIEKLTEIVDGYKDGNIEIDSLYGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NHP3</accession>
    <name>M7NHP3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease</fullName>
            <ecNumber evidence="9">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_03528</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase HII family. Eukaryotic subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="9"/>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875620.1">
        <property type="nucleotide sequence ID" value="XM_007877429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NHP3"/>
    <dbReference type="STRING" id="1069680.M7NHP3"/>
    <dbReference type="GeneID" id="19897215"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03528"/>
    <dbReference type="eggNOG" id="KOG2299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036532_0_1_1"/>
    <dbReference type="OMA" id="RYSWQTA"/>
    <dbReference type="OrthoDB" id="7462577at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990516">
        <property type="term" value="P:ribonucleotide excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07181">
        <property type="entry name" value="RNase_HII_eukaryota_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.460:FF:000001">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000016">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00729">
        <property type="entry name" value="ribonuclease HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF7">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="10">
        <location>
            <begin position="42"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR08088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="308" mass="35453" checksum="1695CE9CE07448F0" modified="2013-05-29" version="1">MIEEDFHEKTVKKKECLIPKNDFYIPTEGTIHSTNKLCHSNSWIAGIDEAGRGPVLGPMIYSIAYCKSSYKKNLKKHGFFERREELFKELYTNDQLRNNVGWSIRIVSAREISQGMLRPDKSYDLNAQAHDATIQLLHEVIKRGFNIKEIYVDTVGPSSSYQTKLQQLFPQINVTVKEKADSIYPIVSTASICAKVTRDRALAMFAINGETWGSGYPSDPKTCEWLKCSIDPIFGWPYEIVRYSWQTAKDLLEKDAKKKNNSKVHVEWYDNCEVDNTKKIQCYFQASKITQEGIDLSWYGENVELSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NHQ9</accession>
    <name>M7NHQ9_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_03546</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875639.1">
        <property type="nucleotide sequence ID" value="XM_007877448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NHQ9"/>
    <dbReference type="STRING" id="1069680.M7NHQ9"/>
    <dbReference type="GeneID" id="19897233"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03546"/>
    <dbReference type="eggNOG" id="ENOG502QW07">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022149_2_1_1"/>
    <dbReference type="OMA" id="CRTFTCL"/>
    <dbReference type="OrthoDB" id="5598844at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013933">
        <property type="entry name" value="CRC_Rsc7/Swp82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597:SF3">
        <property type="entry name" value="CHROMATIN STRUCTURE-REMODELING COMPLEX SUBUNIT RSC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08624">
        <property type="entry name" value="CRC_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="402" mass="46285" checksum="8F016C171A1F6C71" modified="2013-05-29" version="1">MSATFNDLCSPGGSEYGDGDHADEISAVPGRRGRKKSIKHMNLGLSDDDYGASSIKNNKTVIRRGRPPKPKGLSLHISEAPKDISWVEKEVLNDEIVLDEIDFSGEKKVNNFGVLEDGRKYRCRTFTVLGRGDRLYMLSTEPAYVLGYRDPYLFFLKHSSLYNVILNEEEKLDLVQRNIIPESYKRRSVGVVTARSVFREFGFRIIIKGKQVVDDYWESSTFKGQTRSDNVNSDNKLLFENMEYDKNHHISSLGTSSVYQYNPEFESEIYRKKRKVTITDENWMLEHARSASRYNSFLTIQRREKWAFGVYEPHTNTHLRFATSQPTSVRWQGGIDSDKVNSGSKVILETLMEIRPISGSCVHLSDIPKDVYKVCSSEILHAIKERQEEEKNYEYLKIEKCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7NHV5</accession>
    <name>M7NHV5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_03585</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875679.1">
        <property type="nucleotide sequence ID" value="XM_007877488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NHV5"/>
    <dbReference type="STRING" id="1069680.M7NHV5"/>
    <dbReference type="GeneID" id="19897272"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03585"/>
    <dbReference type="eggNOG" id="KOG0737">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_21_14_1"/>
    <dbReference type="OMA" id="CRNAAMR"/>
    <dbReference type="OrthoDB" id="10254455at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140567">
        <property type="term" value="F:membrane protein dislocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140570">
        <property type="term" value="P:extraction of mislocalized protein from mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034214">
        <property type="term" value="P:protein hexamerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000538">
        <property type="entry name" value="ATPase family AAA domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF3">
        <property type="entry name" value="FI08533P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="126"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="366" mass="42395" checksum="C9D7E3E6E86E742A" modified="2013-05-29" version="1">MRDFSFSRRYFLSAGILLVSNVAFYYFFKWIIKSMDPFGEHKARIKEKSNKIILRFRKEYGLFDKKLDLNEYERVIMTEVVLNKDINITFDMICGLEDVISAFKETIILPLHYPELFVSSKILQGLSKGVLLYGPPGCGKTLIVKALAYHSNATFINLHISTLTDKWFGESNKLVAALFSLAKKLEPTIIFVDEVDSFLGKRQKMEHEVMSMIKAEFMSMWDGFSTDENSRVIIIGATNRPNDIDEAILRRMPKRFYIPPPDAFQREKVLKFFLSDVKLETGFSFDFLISKTEGFSVSDIKELCRESVMFPVREFIASNNNLNKKNIDVKDIKNQIRSLEINDFMLSFDSCRIFKNNSSFYDIGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NI92</accession>
    <name>M7NI92_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_03429</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875516.1">
        <property type="nucleotide sequence ID" value="XM_007877325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NI92"/>
    <dbReference type="STRING" id="1069680.M7NI92"/>
    <dbReference type="GeneID" id="19897116"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03429"/>
    <dbReference type="eggNOG" id="KOG2590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_498855_0_0_1"/>
    <dbReference type="OrthoDB" id="340227at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF132">
        <property type="entry name" value="LA-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="358"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="546" mass="61559" checksum="B7A173482D708D8B" modified="2013-05-29" version="1">MEGNEKLSWASAVSSSISLANEDNVMGSIESAPLNSSGTILDKKAASSMSKTNVWKARQERMVKLSNSQSTDSATNNISLKKKQLPVKTLTNGDSLDSENMKLISILSDTESWPTLDKAVSEEGSHEKEKSNPPLTKTSGKEKWVSYTPTITHAKPLPTKPANRIREGKVYDNSFRGSVKNGLATTEEISEVLKNKEHKIDKGKHNKRAGNIHDKRESRVATQITTSKDKNASITQSAGSVKENTNNVKDINGVSNELSLKNLELKDNSNGTREDANRHNHNNVYRPRGGLHMPFIHHNSHPLLNINAFVQTPNIYLPFCPPTYGNLTIPFYPNEKYQQSYMYDYSHINHIGMFMPVIYDPIVLKNCILSQIDYYFSVENLCKDLFLRRHMDSQGWVNLLILANFNRIRSFALEYSFIRDVTTYSRTVDINFSDGYDRVRKKEGWEIWVLPEEERDPSVRNGRTLISSKYPNNEKPSMTGKALKESIDALPFLPRANINTVPFAPRAQEMPSNQPNINVFSQRMSPKALVSSSTKISSINKSEKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJC8</accession>
    <name>M7NJC8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exocyst complex component SEC15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02896</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the SEC15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874933.1">
        <property type="nucleotide sequence ID" value="XM_007876742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJC8"/>
    <dbReference type="STRING" id="1069680.M7NJC8"/>
    <dbReference type="GeneID" id="19896583"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02896"/>
    <dbReference type="eggNOG" id="KOG2176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009437_2_0_1"/>
    <dbReference type="OMA" id="FPFHSEQ"/>
    <dbReference type="OrthoDB" id="10267033at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.670:FF:000002">
        <property type="entry name" value="Exocyst complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.30">
        <property type="entry name" value="Exocyst complex subunit Sec15 C-terminal domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007225">
        <property type="entry name" value="EXOC6/Sec15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046361">
        <property type="entry name" value="EXOC6/Sec15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042045">
        <property type="entry name" value="EXOC6/Sec15_C_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048359">
        <property type="entry name" value="EXOC6_Sec15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702">
        <property type="entry name" value="SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20651">
        <property type="entry name" value="EXOC6_Sec15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04091">
        <property type="entry name" value="Sec15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025007">
        <property type="entry name" value="Sec15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC6/Sec15 N-terminal" evidence="7">
        <location>
            <begin position="50"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex subunit EXOC6/Sec15 C-terminal" evidence="6">
        <location>
            <begin position="395"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR025007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="771" mass="90691" checksum="BB6CB3B2C93538D5" modified="2013-05-29" version="1">MCEFKENDFEELIEQCVLGSSYVEEFMPVLKKACESGTQNDLLQVWTICALQKKEEVEQTCSKYHQIFVESIERLLNVRQSILMLTDQLHYLNWDIQRNVAGLASKKRALVEARRMSQNMKEASEMIRTCLKVLRLVNKIHEWIGNREFYRALRSLDELQTVHLKDILEFRFAKNICDSIPSIKQRIQDAVMRNLKEWLLTLRISSTKVGQLAFQKTLERQKIWNRRIKMDPRLQSCEFNSPVEWVLSEWDDFDVTSNEQIQIDFTCLFESFHIYDELGLHDEFRMSYENDRRMQKDLLIPYSIVIQNKDISAIRSLLQDISGFVIIEKKTLTKISALRSEEEIDSLWDSLCDKLIENISNSIKDVDDLQLIQDIKFLILLFIQTIETYDYSMKKLYNFSLSLFETYSRLLKAQFSKDFEQIVADDDYMPIVISNMEDYQKILDVSWYKPNNFSDSIKFPVTLPFSQVYPLCCVDIRNFVNKYYKFAEGYYNHCHDIDDILKQILDELLVGHVKKKLIERLSLNNLSQLVQIIINLEHFEKACDELDSLLLEIQASDKATNLKLRAKSEFCDAIKDAEKRIFELVNSKIDDFLEISDYDWQSTTKQKEPSSYLLEMVSYLTTVMNSTLHNLPHSIKTFVYFGTLDHFASSMMQKLLNKSSKKINQNSIFNFNLDLQYLEKFVQDLSEPSISYADTFLELRQSLNLILSENPEEYLNSDIQLKKYSRIKPQTAILLLEKLILCETNKPSEERRLSIIRSSENVINSLVNHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJU2</accession>
    <name>M7NJU2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromatin modification-related protein EAF7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874694.1">
        <property type="nucleotide sequence ID" value="XM_007876503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJU2"/>
    <dbReference type="STRING" id="1069680.M7NJU2"/>
    <dbReference type="GeneID" id="19896362"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02671"/>
    <dbReference type="HOGENOM" id="CLU_1454993_0_0_1"/>
    <dbReference type="OrthoDB" id="5595141at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043189">
        <property type="term" value="C:H4/H2A histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012423">
        <property type="entry name" value="Eaf7/MRGBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07904">
        <property type="entry name" value="Eaf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="21729" checksum="75A47DCFCEB5D90D" modified="2013-05-29" version="1">MKEMSCFTVRSAEIWKKLKTFYDLEQLDEISERFRNGGGNFLKDKNGTFDLYFTEFLLPWEEYGEIMEEHRRASDSTSTSPPHLPYGAIGLSKILEEAQEIETFQTESLEPEITDDDLQLYISSNKKKKPLVSRIMRRTNRQEKLNTSVSEKNNVLNTLPNTRTPKSEKPLQNTPSNMRRSSRNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJW9</accession>
    <name>M7NJW9_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874724.1">
        <property type="nucleotide sequence ID" value="XM_007876533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJW9"/>
    <dbReference type="STRING" id="1069680.M7NJW9"/>
    <dbReference type="GeneID" id="19896391"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02700"/>
    <dbReference type="eggNOG" id="ENOG502T0AH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1759589_0_0_1"/>
    <dbReference type="OMA" id="KMANNEW"/>
    <dbReference type="OrthoDB" id="5598843at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="148" mass="16153" checksum="F0198AD68F6D76E2" modified="2013-05-29" version="1">MPLKDEVESRGKRGNGRKSNWTVLGKTGFPIGVASGKGSSTSKSTSFRLSKTPFVETTYVPVRGFNSVEVSSYLNKEWKSALDRANDASFPAKDKPEIYKMANNEWMTKNGSTTSIWSGRGHLMAKGTAFLTELRKSVISNIAEPKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJY3</accession>
    <name>M7NJY3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phenylalanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PNEG_02714</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874739.1">
        <property type="nucleotide sequence ID" value="XM_007876548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJY3"/>
    <dbReference type="STRING" id="1069680.M7NJY3"/>
    <dbReference type="GeneID" id="19896405"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02714"/>
    <dbReference type="eggNOG" id="KOG2783">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022696_0_1_1"/>
    <dbReference type="OMA" id="PISHYPQ"/>
    <dbReference type="OrthoDB" id="4457at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070156">
        <property type="term" value="P:mitochondrial phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.380:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000053">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00469">
        <property type="entry name" value="pheS_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="172"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="16">
        <location>
            <begin position="377"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMR08933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="482" mass="56931" checksum="793AFD87D433DB94" modified="2013-05-29" version="1">MKLLDKGLFGGYFLFQKLNKKSSCSILNNYIFFCRNLSKKTAKKDTEKINTKEYVSILGENYPLDSWTNITPAILKAVEKKLHFQVSHPLGILRQTIESQFDASNYEIFNDFSPVVSTVENFDLLNFPIDHPDRKSTNTYYINKNQILRTHTSAHQVDAFKRMKKNGFLISADVYRRDEIDKNHYPIFHQMEGVRVWKKTKGKSLVERIEMLESNISYVDIIVENATLPFYSEQNPLQKNHQKDEIEAIGKHLMKTIEKIIGYIYEISRPLQDKLNKTTPLKIRWSESYFPFTSPSWELEIFWEGKWLEICGCGIINHELLKIADIPDRIGWAFGLGLERIAMIFFRIPDIRLFWSNDRRFLKQFSPGKISIFQPYSKYPPCYKDIAFWINEEISDKCDLSTTTKKKFCENDFMEIVRNVGGILIEEVKLIDQYIHLETKRKSLCYRINYRSMDKSLSDKEVNKLQEHLRRRITEELDIELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLB5</accession>
    <name>M7NLB5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02401</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874406.1">
        <property type="nucleotide sequence ID" value="XM_007876215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLB5"/>
    <dbReference type="STRING" id="1069680.M7NLB5"/>
    <dbReference type="GeneID" id="19896094"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02401"/>
    <dbReference type="eggNOG" id="KOG2165">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007149_4_2_1"/>
    <dbReference type="OMA" id="TYFMYET"/>
    <dbReference type="OrthoDB" id="5581181at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000033">
        <property type="entry name" value="Anaphase-promoting complex subunit ApcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044554">
        <property type="entry name" value="ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014786">
        <property type="entry name" value="ANAPC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057975">
        <property type="entry name" value="TPR_ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08672">
        <property type="entry name" value="ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25773">
        <property type="entry name" value="TPR_ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01013">
        <property type="entry name" value="APC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="422"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="727" mass="84843" checksum="704171DA7DD8C92E" modified="2013-05-29" version="1">MSGNPPKRTIFNHIFSENLNIKPPDQSTQSIVTAWESASQFFTPEFKYKDVSPNIKTAIHILCHNGLKELLQESYEHSIRIHFTEKFLPILQAYKITQSNFTEFIEKLTEAYHIYQRPLVLTHFNADKSFKKTLHALINNYISEDKLYSVLLEWLSENMAFWEKNESSPQVTCFLSTCKNIELVGLQRHLEKAFSESISRRLNKHIREKYSKKWNRSVQEEIVQWTINKLGKLTFLVLKFDINKKDLYLKLETLACHFLAILRIDELFDIIVDYPYSSVALEDLKRSMKLSPLRDYLVNSFQQSCKTRLLHPGADTQDIISQYISTIKCFLILDPPGVLLDKVAKPIRKHLKNRNDTIKCIMVGLVGDETSELSEELGQADPSSVQVDDDDDDFDNLNWTPDPFDAAPDFQKMNNNDIIKSLVSIYENKDIFVRELQNLLADRLLTTMNYETDKELRNLELLKLRFSENSLQMCDVMLHDIAESKRIDANLHKEFDSNTPIHASILSRLFWPNFKGETLFLSKEIQSYMDDYAENFEKLKASRKLHWIPNLGQVQIEIILEDRTLNMNVRPVQASIILLFQEKDEQTIKDVMDAIGQDYADCRRNTLFWVKYGVLKEISKDTFKVLEYAEVETSNKALSTFEESISNVQVVEDHTSEEMRIYWSFINGMLINLGPLTLERIHSTLQMFVPPPNLYNRSIDELREFLALMVKEEQLEFISGQYKLKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLC5</accession>
    <name>M7NLC5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleoporin Nup159/Nup146 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874416.1">
        <property type="nucleotide sequence ID" value="XM_007876225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLC5"/>
    <dbReference type="STRING" id="1069680.M7NLC5"/>
    <dbReference type="GeneID" id="19896103"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02410"/>
    <dbReference type="eggNOG" id="KOG3630">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_257817_0_0_1"/>
    <dbReference type="OMA" id="RGQCASI"/>
    <dbReference type="OrthoDB" id="248320at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039462">
        <property type="entry name" value="Nup159/Nup146_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16755">
        <property type="entry name" value="Beta-prop_NUP159_NUP214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup159/Nup146 N-terminal" evidence="5">
        <location>
            <begin position="53"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="792"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="871"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="800"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="880"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1262" mass="143706" checksum="495409D6C2BC03D0" modified="2013-05-29" version="1">MLNSFSFLNTSISQPSNEIYVELEELDTDNFGFLSLQHNAYIQIEKNFTDQTPRYNASLLCIGNKNGYYAIGIPSGFAFGTTESLRESLKGNIVKKIVEHNPLSIIHLQKKIINVSFCADEKYLIVVTEENEIMFYCTQKLFQKNNSLEPEFIFQVENIKDILPNPINSNMVAVLTFFGNLHLINFSQRSISEPLVNNITSFSWSQKGKQIVCGTSEGKLVQYTPDGSLKAVINKPKSLNDAYYVSSILWLENHVFFVVYNDYKPTEDLKHDYVIFIITREHNGIITYGKLVDPSPPFGLTSRIDHHFIRYLKNWEPNLKSFVIVAATASADVGIVVRNKDDLIWKTLTISNETRRVSLPYSILNDCDTSPIGIALDFTLSQNIEKPLFPSEEPKEGPPLPILYILNNDYLLTGYYVLYVDAIRAGRTYDFICPIKGNTSDICFNQSAVETAKEFGFGFKPMLVPSLPVLNSKPVFENTLNSQTIGSIANNSVSFGVSFGKPAFGVPVFGNPLFGSSENTGVQNIAFGKKFFNNVSQAIKPSSFASFASLIKSDNESPFGKLVQNSSGTSENKMESIFSKSTPLFSFSDSSRFQNEDDIEDALEMKNESILEDKIDCISNKESETHDNSYGEIEKCFNNNEKNTFMNSQPQSLDASSLSSKISSPFISFGKELSFFSDSKVPSLSSLTVQEKTLSGSFFVDQENQIKREIGSSDARVSFSSSSGVFRFKNNDKIETKEKTVTGLFFKDKNENISELHENYQLSSRSADLPVLSDNISHNDVIKDENYEKNEFNQNNKNEIFGHDFDFPKDNNKKKQPSSSDFFPEHLLSLKGNVSKDSFNVSSNESAIYDINKNLQSQDIFRITENLHENNEEKLDTASPPLSSRNRSIDFSNDNLHKNLKDNSEQTAYNHSKSQDFNALLNTSSTLLSNDLNAFEFKNDDEISFDLSQIKTPSKNIVDETHDDTAKRSPLFKNQYMIKLKPLLSMSEALKAQSKEKGLFKEIDIICRQMDNELNIIQENLERLSLFIEDQKENNSVENDSVCIFRRHIEEWKLEEIPRMGKMIFDLLNDISNFQKIEDTNLDIIKSLKKTFIKLEAKHIEVSRFIRARTDHEFTRMIKVRQLGSEHLENQIKLRKICQNVENYLWKAEEGFALYKAKLAGKTNGNIKLPSLESIKKVLGKINSLIQQSMNETNNLEFEFKRLKTDLFLKTKDIKSKTRKNLSFSENMLSIITADMLRKDKFLIILKELMRERNPLHTTIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLM5</accession>
    <name>M7NLM5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FACT complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_03537</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase M24 family. SPT16 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875629.1">
        <property type="nucleotide sequence ID" value="XM_007877438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLM5"/>
    <dbReference type="STRING" id="1069680.M7NLM5"/>
    <dbReference type="GeneID" id="19897224"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03537"/>
    <dbReference type="eggNOG" id="KOG1189">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004627_1_0_1"/>
    <dbReference type="OMA" id="YHINTIP"/>
    <dbReference type="OrthoDB" id="10251642at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140713">
        <property type="term" value="F:histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140719">
        <property type="term" value="P:constitutive heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045899">
        <property type="term" value="P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007063">
        <property type="term" value="P:regulation of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01091">
        <property type="entry name" value="CDC68-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000002">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.210:FF:000001">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000017">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000005">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.210">
        <property type="entry name" value="FACT complex subunit Spt16p/Cdc68p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029148">
        <property type="entry name" value="FACT-SPT16_Nlobe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056595">
        <property type="entry name" value="Fact-SPT16_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013953">
        <property type="entry name" value="FACT_SPT16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040258">
        <property type="entry name" value="Spt16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033825">
        <property type="entry name" value="Spt16_M24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980">
        <property type="entry name" value="CDC68 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980:SF15">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14826">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24824">
        <property type="entry name" value="PH_SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08644">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01285">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01286">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FACT complex subunit SPT16 N-terminal lobe" evidence="12">
        <location>
            <begin position="12"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="FACT complex subunit SPT16 middle" evidence="13">
        <location>
            <begin position="528"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="14">
        <location>
            <begin position="801"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="423"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="923"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="459"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="923"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="977"/>
            <end position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR08097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="991" mass="113914" checksum="DBF2C96B0D164426" modified="2013-05-29" version="1">MEGKDCLIFCFEEALNYVHIKEHVFFEITSMLVVQGSLSDDNPYSKTSSIHNWLLGYEFPDMLMLLTQEMIYFLTSDKKATILETLKDGIEAFPMTILRRSKQATENEVALKQVVDAMEKAGKRVGVFSRDTLKGKFADEWKSVYGKTSFEEVDVSLGVSLAMAVKEEDELKCIRLACKASVLLISTYFVDKMSTIIDEEDKVSHLQLSEMVERKLEEESFFRSKMGSDFDPEQLEWCYTPIIQSGGNYDLRPSAVSDDHLLQGNVILCSLGLRYKSYCSNVGRTYMIDPNEFQENYYDFLLLLQKKIFESIKDGVVVKDIYNKAVGLIRVKHPELESKFVRNIGFGIGIEFQDKTLILNSKNNRVLKDGMTLNISIGFNDIENPKPLHIRDRTYSLLLIDTIKVTKDAPIVYTDSPKSYNDISYYNDDEPIENENISKKRPERKVSAANSAILRRKTRGENKDVDDSAEQRRKQHQKELAEKKQEEGLARFSNGDGIQNGIEKPTLKKIESYKRDSQMPSSIKTLKIIVDIKNSSIIVPIYGRPVPFHISTLKNVSKNDEGEFVYLRLNFLTPGQGVGKKDDMPFDDLSASFIRSLTFRSSDTRHMSEVFLSIQEMKKNVAKREAERREMADVIEQDNLIEVKNRRPLKLVDVFSRPALDGKRVPGELEIHQNGLRYQSPLRSDHKIDLLFSNIKHLFFQPCDHELIALIHVHLKNPIMIGKRRAKDVQFYREASDMQFDETGNKKRKYRYGDEDELELEQEERRRRAALNKEFKAFSEKISESNEGVIDVDIPVRELGFTGVPFRSNVLLQPTTECLVHLTDPPFLVITLSDIEIAHLERVQFGLKNFDLVFVFKDFRRPPAHINTIPMSQLDNVKDWLDSVDIAYTEGVLNLNWVTIMKTINDDPLAFFEEGGWAFLNNESDEESAESEEEGSEFAVSEDDESEEESDYEENASDDESEVDEEDLSEADDWDELEKKASRDDAKKSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLW8</accession>
    <name>M7NLW8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875667.1">
        <property type="nucleotide sequence ID" value="XM_007877476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLW8"/>
    <dbReference type="STRING" id="1069680.M7NLW8"/>
    <dbReference type="GeneID" id="19897261"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03574"/>
    <dbReference type="eggNOG" id="KOG3772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107716_1_0_1"/>
    <dbReference type="OMA" id="RCTNIPC"/>
    <dbReference type="OrthoDB" id="102559at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF38">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="22"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="144" mass="16934" checksum="C8D2616D0DE57449" modified="2013-05-29" version="1">MIDFTYIEPQELCLKLKNTENKAKDIIIVDVREDDFIGGHIKGALHIPSYKLSSHILNLVEETKKAKEIIFYCSFSQQRGPAGARLFLVEQQKIHNIKGIQEKTIFPKVYVLRGGFVEWQKKYGNDEKLTDKYNKELWEKKFWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M7NM54</accession>
    <name>M7NM54_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875542.1">
        <property type="nucleotide sequence ID" value="XM_007877351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NM54"/>
    <dbReference type="STRING" id="1069680.M7NM54"/>
    <dbReference type="GeneID" id="19897301"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03614"/>
    <dbReference type="HOGENOM" id="CLU_022141_0_0_1"/>
    <dbReference type="OrthoDB" id="5464814at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005689217" evidence="1">
        <location>
            <begin position="18"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="539" mass="61580" checksum="B40F8EF00A72AF10" modified="2013-05-29" version="1">MKIILFFLFTFITYVLSETFGPLGFATLMPPFKPPGTEHRFFKNLVSKIYNYDDILLFLTKGDTRSCLQHLSDACEELTRVYGDLSKIGDAVKSICEHQREACQKLPKVKEDLCRDQSDTYDYLMTFLLSGTDCHTAYTKCRLRSRGCSSELSRKCRTLLSICNYAYNEERFHVLLVNSLDDFTSESFRGKLKKLCNELSFLGDHFVRLCLNPDSLQSLLPTIRDSLRKSSLPFRSYPKMSMGALLGAMKLDGGLYSPKNNPTVDPSYFMGYLLGQLKPISFESDCIEICQRCLGLDFFSQSAYFCDAKTTASQNSVCAKTRVELFEQHIPNLKKELQNKLPDEQYPEIVSLSGIDVDLCKKFLGPCSYLKDLDPTLYSLCDRLKGHCVFDLEIASSLTVYEYYFRKVFLRKDSNTHLDLCQKVLPRICGFTLNTTVDFLTFCLNPTHTCFSLAALVSLRCDRIKEEMTQVDPSHEDCVTKLREAETYGSLCTENEEYVKFLTICYNKNPLDEYLKGLADSKLKKSTPENKFGKLDDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M7NM59</accession>
    <name>M7NM59_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_03437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875524.1">
        <property type="nucleotide sequence ID" value="XM_007877333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NM59"/>
    <dbReference type="STRING" id="1069680.M7NM59"/>
    <dbReference type="GeneID" id="19897124"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03437"/>
    <dbReference type="HOGENOM" id="CLU_022141_0_0_1"/>
    <dbReference type="OrthoDB" id="5464814at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082283" evidence="2">
        <location>
            <begin position="18"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="549" mass="62595" checksum="522973103CA3C99D" modified="2013-05-29" version="1">MKIILFFLFTFITYVLSGTFGPLGFATLMPPYTTSTSELHFKDDLISGTYSSDELLMFLTGGNIGSCLRRLSYSCGELTKVYGDLSRIGNAMKNICEHYYEACRRLPKIKKELCNLDEVTYNDKLEKTSPLDSNQCFYSYIKCRLRSRACSYKYMEECRTLLHACQRSYSKYELHTLFTNLISDDYNSESFRKELKVLCRDLFNTSDLFVQLCLNPDLLVSELGKFNFLRKEGRGGFFSYPHVSIGALLDAQELDGNLFLPRTDPSVNPVYFMAYLLGQRGSTSFVSDCLEISQKCLGLDFFPQSSYFCEAGSSTSRSSACKRAEVTLLEQDVPNLKNELQRKLRDRLHPDTIFWTGVDVDLCTEFLKSCSYLKKLDSRLDRLCTLLEGHCAHGLEVGSSLSVFNNYFNGVDITSRPVSQLDLCREALPQICTVILNKTVDFLTFCLRPSHTCLALKELDSVRCKGFKSVLATTDPTEQQCDDLFSKIGVYREKCRVLKGYNEFLTTCYTKYPHNWFLKSLKDSDPSRFAPRLDFGKPDDDDNDDDGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M7NML8</accession>
    <name>M7NML8_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873645.1">
        <property type="nucleotide sequence ID" value="XM_007875454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NML8"/>
    <dbReference type="STRING" id="1069680.M7NML8"/>
    <dbReference type="GeneID" id="19895376"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01682"/>
    <dbReference type="HOGENOM" id="CLU_1504068_0_0_1"/>
    <dbReference type="OMA" id="IKCCCGT"/>
    <dbReference type="OrthoDB" id="4088568at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="68"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="179" mass="20939" checksum="BB79F575890234AA" modified="2013-05-29" version="1">MSSIKCCCGTDCLNIKQNRLLFKQFEKDMQIASELGQYLLSEYRTYNENAEYREKLFKLEISHLKIKKDQITSSLSFLKKRNKELEEEISRINEKNGNILSNMEKLNILLSNSESNIKDLSNTLEATKLELELARSVIDRKKAIEKHIDAMEIEKNLLRKELEQSLEIGIFFKKKMATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMZ4</accession>
    <name>M7NMZ4_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_03322</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875398.1">
        <property type="nucleotide sequence ID" value="XM_007877207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMZ4"/>
    <dbReference type="STRING" id="1069680.M7NMZ4"/>
    <dbReference type="GeneID" id="19897009"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03322"/>
    <dbReference type="eggNOG" id="ENOG502S9JT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064565_1_0_1"/>
    <dbReference type="OMA" id="IHLAHLM"/>
    <dbReference type="OrthoDB" id="18453at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007128">
        <property type="entry name" value="PMF1/Nnf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15459">
        <property type="entry name" value="POLYAMINE-MODULATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15459:SF3">
        <property type="entry name" value="POLYAMINE-MODULATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03980">
        <property type="entry name" value="Nnf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="207" mass="23512" checksum="D8E2D57B3242FC8E" modified="2013-05-29" version="1">METGKNSQDSSQCLKKGLRAQRLQDLLDKSLSQTVKACSYEQIAKCFPTLAKNSPEILKNAHEQVISFLKSSCDREFSAIFKERDVVSRLNELDGIITDAKSRQERGDPSTVLSAFLSPENIINSYLYPLMIKEHSVLKNQLETIQMQNADFYEKISSQREEIIQLITFMKKTIEELDLAVQRSIQTPIQTLQAQMDEIVPILQAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN47</accession>
    <name>M7NN47_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_03125</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875184.1">
        <property type="nucleotide sequence ID" value="XM_007876993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN47"/>
    <dbReference type="STRING" id="1069680.M7NN47"/>
    <dbReference type="GeneID" id="19896812"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03125"/>
    <dbReference type="eggNOG" id="KOG3028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_771875_0_0_1"/>
    <dbReference type="OMA" id="WRTWTKE"/>
    <dbReference type="OrthoDB" id="5835136at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03078">
        <property type="entry name" value="GST_N_Metaxin1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019564">
        <property type="entry name" value="Sam37/metaxin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10568">
        <property type="entry name" value="Tom37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal" evidence="8">
        <location>
            <begin position="22"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="9">
        <location>
            <begin position="199"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="41437" checksum="77FF0BC4047157CF" modified="2013-05-29" version="1">MTPLELHIHFPGFDLPSIDPYCLSVLCYLQITAPGLYSVIYSNNNTLSPTGKLPALRDSGTWVGGWNNIIDYLKQKGFDADNSLTDIQKADSIAYESLIHGLGFDLTLFNIYVDDENYSNITRPLYYKKYFSFLSSYLSLIHIRNFAKKRTQYFDIKQTYSKEMRNFHSIFYYHLKNTSCDFKKEAKIEKLKVLSSNFYRLLAFKLSSQPFIFGDQPTSLDCLIFGHIALQFFPSLPNSTLSEHLKTTEPLLVSYLHHSFSKYFQENKPLNIEITKSNYFYNTTTILWNNFISFSPFIQLKELVGVNSPEKRRKFFTVAASILGFISYIYITGIIKIEIEDQNKDGSENTGLLNNDSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN86</accession>
    <name>M7NN86_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cullin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_02870</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874907.1">
        <property type="nucleotide sequence ID" value="XM_007876716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN86"/>
    <dbReference type="STRING" id="1069680.M7NN86"/>
    <dbReference type="GeneID" id="19896557"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02870"/>
    <dbReference type="eggNOG" id="KOG2166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004747_6_1_1"/>
    <dbReference type="OMA" id="IREWDRY"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000007">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000011">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000026">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000003">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000029">
        <property type="entry name" value="Cullin homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1030.10:FF:000002">
        <property type="entry name" value="cullin homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1030.10">
        <property type="entry name" value="Ring Box Chain A, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="13">
        <location>
            <begin position="400"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR08692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="760" mass="88456" checksum="C88516E7851A3897" modified="2013-05-29" version="1">MQDLPRSDDLEGTWKFLEKGVSQIMENMEEGLSFSKYMENYTVVYNYCARPKTNADISMNESSKGANLLGNELYYNLVRYLSSHMQSIKNESLKYNDEALLQFYSHQWSKYTSASFCIHHIFKYLNNFWVKRKIDEGKTGVYNVYTLALVRWKLDMFDDIHEKVTETLLKVIEKQRNGEIINTSLLKNVINSYVSLGLDEKDSSKLVLDVYNNYFEKPFIASTEVYYRIEAEKYISENSITDYMKKVEARFNEEKTRIQLYLHPNTTKVLMNVCDHVFIQNHSEILQDEFQNILDSDRQEDMTRMYTLLSRIPDGVNPLKVKFEAHVCKAGLLAVERIVDDSTNSVDPKSYIDALLEIRSQYNTLVATAFKGDMEFIKALDNACHEFINRNKVCRLSSSKSPELLAKYCDSLLKKNSKYVEESDFENTLINIMTIFKYVEDKDVFQKFYSKMLAKRLINGTSASDDAETSMISKLKEACGFEYTNKLQRMFQDIGVSKDLQESFKESLKKTLDPYNSQINFYIIVLGTGFWPLQPASTPFNIPNELVDIYEKFQLFYQKKHNGRKLNWLFQLSKGELKVNYLSNTKVAHTFQVSTYQMGILLAYNTSTSLSYEKLQEITALNKDVLDASLSILVKAKVLLLFPPDMAVGDSNTRYDLNMNFKSKKIRVNLNMPTKIEQKQESDETHKTIEEDRKLLMQSTIVRIMKARKILKHVVLIQETISQIKSRFIPKISDIKRCIDVLIEKEYIKRSGKDEYSYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNB2</accession>
    <name>M7NNB2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">H/ACA ribonucleoprotein complex subunit CBF5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">H/ACA ribonucleoprotein complex subunit cbf5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02895</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>uridine in 5S rRNA = pseudouridine in 5S rRNA</text>
            <dbReference type="Rhea" id="RHEA:47036"/>
            <dbReference type="Rhea" id="RHEA-COMP:11730"/>
            <dbReference type="Rhea" id="RHEA-COMP:11731"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874932.1">
        <property type="nucleotide sequence ID" value="XM_007876741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNB2"/>
    <dbReference type="STRING" id="1069680.M7NNB2"/>
    <dbReference type="GeneID" id="19896582"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02895"/>
    <dbReference type="eggNOG" id="KOG2529">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032087_3_2_1"/>
    <dbReference type="OMA" id="KYGRTNE"/>
    <dbReference type="OrthoDB" id="10250002at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000495">
        <property type="term" value="P:box H/ACA sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02572">
        <property type="entry name" value="PseudoU_synth_hDyskerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21148">
        <property type="entry name" value="PUA_Cbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003280">
        <property type="entry name" value="PRK04270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dyskerin-like" evidence="10">
        <location>
            <begin position="25"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="9">
        <location>
            <begin position="274"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="424"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="449"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR08717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="463" mass="52407" checksum="27C9DC2806046C37" modified="2013-05-29" version="1">MSSVAEIQVKTDYLIKPENLSGNADTSTWPLLLKNYDKLVIRTGHYTPIPHGSSPLKRDLKTYISSGVINLDKPANPSSHEVVAWIKRILRCEKTGHSGTLDPKVTGCLVVCIDRATRLVKSQQGAGKEYVCVIRFHDALSSEKKFAQSLETLTGALFQRPPLISAVKRQLRIRTIHESKLLEFDNDRHLGVFRVSCEAGTYIRTLCVHLGLILGVGAHMQELRRIRSGCLSEMDGMVTMHDILDAQWEYDNTRDESYLRRVIRPLESLLVSYKRIVVKDSAVNAICYGAKLMIPGLLRYESGIELNEEVVLMTTKGEAIALGIAQMSMVELSTCDHGVVAKIKRCIMERDTYPRRWGLGPQSMKKRILKKEGKLDKYGRINDATPEEWKSTYVDYNLPSEQLSTQVKKVAEAESIQDKTTSIKTDILVKEKRKKDRMDESKASDNSEKKRKIEKKKKDKSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NND8</accession>
    <name>M7NND8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PNEG_01481</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873420.1">
        <property type="nucleotide sequence ID" value="XM_007875229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NND8"/>
    <dbReference type="STRING" id="1069680.M7NND8"/>
    <dbReference type="GeneID" id="19895177"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01481"/>
    <dbReference type="eggNOG" id="KOG0328">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="OMA" id="TRFHDFK"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18045">
        <property type="entry name" value="DEADc_EIF4AIII_DDX48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000498">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="55"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="236"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMR10208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="397" mass="45106" checksum="9CAA8AE5936F32F8" modified="2013-05-29" version="1">MALKEDRNGNKTVFTTSKEVTVAGSFEEMNLKEDLLRGIYSYGYELPSAVQSRAITQILKGRDVIAQAQSGTGKTATFSISILQVIDTAVRETQALVLSPTRELAVQIQNVLLALGQYQNVQSHACIGGTNIGEDIRKLDHGQHVISGTPGRVADMIRRRNLRTRNIKMLVLDEADELLNRGFREQIYDVYRYLPPGTQVVVVSATLPYDVLELTTKFMTDPVRILVKRDELTLDGLKQYFIAVEKEEWKFDTLCDLYDTLTITQAVIFCNTRRKVDWLAEKMREANFTVSSMHGDMPQKERDAIMGEFRQGNSRVLLCTDIWARGIDVQQVSLVINYDLPPNRENYIHRIGRSGRFGRKGVAINFVTAEDVRILRDIEQYYSTQIDEMPMNIADLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNE9</accession>
    <name>M7NNE9_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_03120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875178.1">
        <property type="nucleotide sequence ID" value="XM_007876987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNE9"/>
    <dbReference type="STRING" id="1069680.M7NNE9"/>
    <dbReference type="GeneID" id="19896807"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03120"/>
    <dbReference type="eggNOG" id="KOG0974">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002615_1_0_1"/>
    <dbReference type="OMA" id="GGAHRQW"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051973">
        <property type="entry name" value="tRNA_Anticodon_Mtase-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="199"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="241"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="774" mass="89795" checksum="7FC0ADA3FA0BBD33" modified="2013-05-29" version="1">MIIQIPDFKLEKNTWLKSLGFHGPITSLLFFNKFILFAGQGPYIKIYDVIQGLLIHTVKVFKKNRIHGIVYAKKNTLILWGGKDFCIVNLDDLFNNYDFDIHYTLDWIFDAKPSCDKLYIWLATAHNKVHLYDIQTKCYIQTFSCTENPLLYSSCLYIHCDGSVTIVSGTVFNEIYVWNINNVEIAKRKDLMIQITHRLRGHEGIVFKINFSKNGKLFCTCSDDRSIRVWDINSGKCKATGWGHDSRIWDVKFIGNDESKLISVSEDTTARLWRITSESELEQDSVYDGHEGKNIWCVSVFENIFATGGNDGKIRLWEINDKEKFQYYITPYDIKNALSSFNRLYDNFRSYVLVNSFQILIVSMSGRVLIHSIKTKKSNYLFYDLDLIGFSKVSLWSKTDFVNISDKFGNIYVLNIKNKLSTSKYHICDEKIQSLFPISFGDSLYLITVSAISLRIHFHLFKYIESSFIYEKNDIISIAPVELTAATIDFKTNLIFLGFKTGLLSIHRLEDFGKGLSSIYLVEDLYKKNSLSTIILHPHENTLLNKKLEITTIGRDWVYYILELTIHNGYNNDNKISIEKRHQGKCNKHGIEGGFYLKGDLILYGFKKLRFSIWNQSKGFRIFSVICGGSHRHWSIYFSCSEKNGNSVFIFTRSNSIIVCNFLLLFPFQNFQKTILQGGRHGREIRSMAFYPILYQRNTLLFLTGAEDTTLRLSKLYITNYSEIINIYREKEHDTGIEKISWSKNGLFFFSCGGAEEFVAWKFSMKDLNQVRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNI2</accession>
    <name>M7NNI2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02864</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874901.1">
        <property type="nucleotide sequence ID" value="XM_007876710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNI2"/>
    <dbReference type="STRING" id="1069680.M7NNI2"/>
    <dbReference type="GeneID" id="19896551"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02864"/>
    <dbReference type="eggNOG" id="KOG0184">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_0_0_1"/>
    <dbReference type="OMA" id="RVSMYMH"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03751">
        <property type="entry name" value="proteasome_alpha_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000007">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="249" mass="27837" checksum="14A40755D32D859E" modified="2013-05-29" version="1">MTSIGTGYDLNNSTFSPDGRIFQVEYAYKAIENSGTALGIKVKDGIVLAVEHLVQSKLLIPGSNKRIYTVDEHIGIAIAGLNTDGKHFVNRAREEAKNWRDIYRTPIPSSSLTDRMGNYVQVYTLYSSVRPFGTSCIIASIENSTPKLYMIEPSGNYWGYNGVAIGKSQCEVKNEIEKLKLDELSLYEAVKAAIKIIRSTHNESKDKEYEIEVSWIGLTETKGQHQLVPKHIVDTIIAELKSSEEMIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNW0</accession>
    <name>M7NNW0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_02727</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874753.1">
        <property type="nucleotide sequence ID" value="XM_007876562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNW0"/>
    <dbReference type="STRING" id="1069680.M7NNW0"/>
    <dbReference type="GeneID" id="19896418"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02727"/>
    <dbReference type="eggNOG" id="KOG0845">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_866330_0_0_1"/>
    <dbReference type="OMA" id="ETHITGR"/>
    <dbReference type="OrthoDB" id="2538017at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024882">
        <property type="entry name" value="NUP58/p45/49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437">
        <property type="entry name" value="NUCLEOPORIN P58/P45 NUCLEOPORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437:SF2">
        <property type="entry name" value="NUCLEOPORIN P58_P45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="321" mass="35827" checksum="5F9511B175329529" modified="2013-05-29" version="1">MFEASKPFSIGNKEPSSNNIFSFGSSTQTNAPTSQPTFSFNTQLQQDKSQNLSALETKTASSNSNISISNVPNPLSQSSTGFSFGNPFQKTDTCNITVNPLQTSNTQNISLSQSDPTLQSSQMISSATHYTEIPKDERDFLDEMDKYIITQIQISDYLQSQASSIDELVKSVPKDVEEVTKRSDQTATDLISDVNQLMSLKMTVDNDYNNAKLSKNVIDSVPMPYIDCSRVKDPILAYFENTSNEIEKKINNYAKNIEDLEKHLEYLEKDHSENKTSPEALLNTLKAEYDFFLALSNSAAEVHDKIKQLQIHNLGTNLVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP41</accession>
    <name>M7NP41_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Eukaryotic translation initiation factor 2 subunit gamma</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02656</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874677.1">
        <property type="nucleotide sequence ID" value="XM_007876486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP41"/>
    <dbReference type="STRING" id="1069680.M7NP41"/>
    <dbReference type="GeneID" id="19896347"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02656"/>
    <dbReference type="eggNOG" id="KOG0466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027154_0_1_1"/>
    <dbReference type="OMA" id="NIGMVGH"/>
    <dbReference type="OrthoDB" id="1045173at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990856">
        <property type="term" value="F:methionyl-initiator methionine tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045903">
        <property type="term" value="P:positive regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000011">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000065">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003077">
        <property type="entry name" value="PRK04000.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="27"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR08871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="455" mass="49460" checksum="58880E70CDADBD8C" modified="2013-05-29" version="1">MASDQCQEVFVDPSTLHPCSPEVIARQATINIGTIGHVAHGKSTVVKAISGVLTVRYKNELERNITIKLGYANAKIYKCSSESCPRPGCYKSYGSDIKENVICERPGCGSKMNLIRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLQHIIILQNKVDLMREEAAEEHYNSILKFIKGTIADSAPVVPISAQLKYNIDAILEYIVKRIPVPIRNYSCDPRLIVIRSFDVNKPGAEVDDLKGGVAGGGILAGILRLGDEIEIRPGIVTKDSEGKFHCKPILSRIVSLFAEHNDLKFAVPGGLIGVGTHVDPTLCRGDRLVGQVLGLKGRLPAVFVAIEINYFLLRRLLGVKTLDKKQAKVQKLAKNEVLMVNIGSTSTGGRVVSVKADLAKLILTSPACTEVGEKVALSRRIEKHWRLIGWGKIQNGQTLDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPC3</accession>
    <name>M7NPC3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent RNA helicase DOB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02455</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874464.1">
        <property type="nucleotide sequence ID" value="XM_007876273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPC3"/>
    <dbReference type="STRING" id="1069680.M7NPC3"/>
    <dbReference type="GeneID" id="19896148"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02455"/>
    <dbReference type="eggNOG" id="KOG0948">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002902_0_1_1"/>
    <dbReference type="OMA" id="IMLKNYN"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004532">
        <property type="term" value="F:RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071042">
        <property type="term" value="P:nuclear polyadenylation-dependent mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000292">
        <property type="term" value="P:RNA fragment catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140746">
        <property type="term" value="P:siRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18024">
        <property type="entry name" value="DEXHc_Mtr4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13154">
        <property type="entry name" value="KOW_Mtr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000083">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.300:FF:000001">
        <property type="entry name" value="Mtr4 exosome RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000002">
        <property type="entry name" value="superkiller viralicidic activity 2-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="149"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="415"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1057" mass="121397" checksum="3B32AA76BA9745C0" modified="2013-05-29" version="1">MFSREVFSVFNGNEKSEDNTNISKESLLLEVNFEKNEDKAKETRSMDFDGDSKSKKIKLEEETGNNLIVTDSFETQGTFEILGHKRLISAKEDLEENAEIEKLILNHQVRHQVALPVNYSYIPISQHVAPAEPAKKYEFKLDPFQQVAIASIEKNESVLVSAHTSSGKTVIAEYAIAQSLRDKQRVIYTSPIKALSNQKYRELLTEFGDVGLMTGDVTINPTASCLVMTTEILRSMLYKGFEVMREMAWVIFDEIHYMRDKERGVVWEETIILLPDKVRYVFLSATIPNAMQFAEWICKTHVQPCHVVYTDFRPTPLQHYIFPVDGDGIHLVVDEKGVFREDNFQKAINVLAEKFGEDPNAVPTKKIGKKGKPGKTSHKGPSDIYKIIKMIMIKNYNPVIVFSFSKRDCENLALQMSKLDMNDDTERDLISSIFNNAINSLSEVDRQLPQIQYILPLLRRGIGIHHSGLLPILKEVIEILFQEGLIKVLFATETFSIGLNMPAKTVVFTNVRKFDGKDFRWISSGEYIQMSGRAGRRGLDDRGIVILMIDEKMEPSVAKNMLKGEADRLESAFHLGYNMILNLMRVEGISPEFMLERSFYQFQNNAEIPKIESKLLKLEKERDSIIIEDKTNIANYYELRQQLEAYSDEMRNIINHPDHCLQFMQPGRLVKVKDKFSDFGWGAVVNYCKRVSPKDSSEEYPPHESYIIDILLWVAADSQITKTNNDYAQGIYPPKGEAGKMEVIPVLLSSINGIGHIRIFLPKDLKALDQRLTVYKSIEEVKRRFPDGIALLDPIENMNIRDESFRNLLRKIEILEHKILMNPLFNSPQLPDLYEKYSKKMEIKSQIKTIKKKISETQSIIQMDELKCRKRVLRRLGFTTSEDIIEMKGRVACEISTGDELILTEMIFNGVFNNLTSEQSAALLSCFVFQEKSEETPKLKEELAAPLRKMQEIVRRIAKVSRESKLNIVEEEYVNQFKPTLMDVVYAWAQGKSFFQICKMTDVYEGSIIRAFRRLEELLRQMCSASRVIGNIELETKMTNAINLIKRDIVFSASLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPS5</accession>
    <name>M7NPS5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GDP/GTP exchange factor Sec2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00858</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872768.1">
        <property type="nucleotide sequence ID" value="XM_007874577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPS5"/>
    <dbReference type="STRING" id="1069680.M7NPS5"/>
    <dbReference type="GeneID" id="19894556"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00858"/>
    <dbReference type="eggNOG" id="KOG4324">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009486_1_1_1"/>
    <dbReference type="OMA" id="TCFIEDA"/>
    <dbReference type="OrthoDB" id="1748564at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071341">
        <property type="term" value="C:medial cortical node"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090619">
        <property type="term" value="C:meiotic spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035974">
        <property type="term" value="C:meiotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21044">
        <property type="entry name" value="Rab11BD_RAB3IP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF0">
        <property type="entry name" value="SEC2P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25555">
        <property type="entry name" value="RAB3A-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="3">
        <location>
            <begin position="32"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="46"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="131"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="458" mass="53060" checksum="3535DAFDC489BAF3" modified="2013-05-29" version="1">MEEGSSPIFVENRLNKELSMLNSKLVASIEKQASLEDNIHWTCHELMLAKEKIRELEASQKDYMNRMEQALLEKQDVEKEIQQLMARLMEEKQQRGKAEIYKHTVEKELEDLTKTLFEEANRMVSSAHRDRDRLEKYNEHLQAKLKDTEGLLHYHEKQLAELKDVMQHMSNEEGGSIPSTPKKSENRISIGKNNELIREIEEEEKQESSMCSTGLFIRRDIPIFQEFMIFLQGLRSQKNQTSSTQGMNMALTSETLLNSISSLDLPIYHGLNGSSNTVQTLTTSSSFQINNLGSSNFFKDSKFIKRCIYEDIEPTLRLDNSPSLSWLARRTVLSSILDGNLVIEPISSKSFDMPFVCALCGNNCCDDKDTRIHQFRTSEFRNPPKSHLLCSYCLRRLRSVCNFAGFLRQLRDGLWKTDDENIEIKAWEEVIRLREAMFWSRIGVSDQMESIQNKTDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPW7</accession>
    <name>M7NPW7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Transfer RNA methyltransferase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TRM8</name>
        <name evidence="12" type="ORF">PNEG_02249</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10 11">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a complex with TRM82.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="11"/>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874237.1">
        <property type="nucleotide sequence ID" value="XM_007876046.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPW7"/>
    <dbReference type="STRING" id="1069680.M7NPW7"/>
    <dbReference type="GeneID" id="19895942"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02249"/>
    <dbReference type="eggNOG" id="KOG3115">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LPNYFAK"/>
    <dbReference type="OrthoDB" id="47276at2759"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106143">
        <property type="term" value="C:tRNA (m7G46) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000060">
        <property type="entry name" value="tRNA (guanine-N(7)-)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03055">
        <property type="entry name" value="tRNA_methyltr_TrmB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025763">
        <property type="entry name" value="Trm8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00091">
        <property type="entry name" value="tRNA (guanosine(46)-N7)-methyltransferase TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417:SF16">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 11" id="KW-0820">tRNA-binding</keyword>
    <feature type="active site" evidence="11">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="92"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="127"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="225"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR09287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="250" mass="29641" checksum="65974F94EB4388A1" modified="2013-05-29" version="1">MMRKDKKSRKRQEHVLNMLPRKKFYRQRAHSNVFSDHILDYPANPSMMDWSVHFPDIDKNKKVEILDVGCGFGGLLIALSTLYSDTLILGVEIRMQVTQYVHDKIIALRHQFSENKAYRNISVIRTNAMKFLPNFFYRHQLSKMFFCFPDPHFKKSKHKARIITFTLLTEYAFILQPQGILYTITDVEDLHHWMVAHLDYHPLFQRLSQQELHLDPCISVMTSQTEEAKKVSRNNGQKFIACYKRLDDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ71</accession>
    <name>M7NQ71_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00999</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872913.1">
        <property type="nucleotide sequence ID" value="XM_007874722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ71"/>
    <dbReference type="STRING" id="1069680.M7NQ71"/>
    <dbReference type="GeneID" id="19894697"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00999"/>
    <dbReference type="eggNOG" id="KOG1607">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028277_2_0_1"/>
    <dbReference type="OMA" id="KLYCLLQ"/>
    <dbReference type="OrthoDB" id="537032at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF0">
        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005225">
        <property type="entry name" value="LAG1_LAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="8">
        <location>
            <begin position="116"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="359" mass="43473" checksum="F57C62A53F1C8604" modified="2013-05-29" version="1">MKKYSDGRIKKDKQLSYLNFGRFIKQNIRYFAVYQQKILIATILFIICIHIFTSQNFTKKLLKLSYCNSATQLCSKGKDDWYFVGFWVILFTLMREVCIRHIFIPFGRNHGIISTRNLNRFSEQTWSFIYYVVFWSFGMYISYNSPYWLNPKQLWIQYPQVDLKPHIKWYYLVQFSFWIQQIFVVNIEKRRKDYYEMFFHHIITCTLIFMSYIYHFTQVGNAVMCIMDLSDIFLPLSKMLKYLKMHKTCNLSFFIFFLSWIITRHILFVFIVYSTYKDAGVIITHKWDPVNNIYFTKKIHMSFLALLTALEIILFFWLCLIIKVTWQVISGHNAKDTRSDSEDENDLALNKKKYKNTYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ88</accession>
    <name>M7NQ88_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02375</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat UTP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874380.1">
        <property type="nucleotide sequence ID" value="XM_007876189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ88"/>
    <dbReference type="STRING" id="1069680.M7NQ88"/>
    <dbReference type="GeneID" id="19896068"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02375"/>
    <dbReference type="eggNOG" id="KOG2055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011055_1_0_1"/>
    <dbReference type="OMA" id="KIRMWEI"/>
    <dbReference type="OrthoDB" id="1935146at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000292">
        <property type="term" value="P:RNA fragment catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045161">
        <property type="entry name" value="Utp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359">
        <property type="entry name" value="WD-REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="288"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="554" mass="62312" checksum="C6DFB5EA2DCD4A05" modified="2013-05-29" version="1">MGQKSKKSKAIHKNRPSEKYIDSIFSDFSLNSNGKDKEEEILEAKVFGNNNSFNEELKNSLLNISNSDESESFGDRTVDFSLLQDHELFYVDTSTCQNELADSLNKTATLRIDEERPAWEDSDDERLLISLASVGRLRKLRESEKEDIINGKEYNIRLRKQFERINPVPNWVVLSKSLNDENLKQNGNIGDDNSDNSYFLNDVSIFTKSLKSLFESSEGYIRKTLSVLPPTTINIKRLKDANACSPSESAILSLSFHPFYPLLLSGGYDRILKIFHIDGDVNPLVSSLYLHSSSIQTAVFHPNDNKIIVGGQRKYFYIWDLESGNIRKVSRTYGHDDIQGSMEKISVSPCGKFIGIVGNKGWFNVLSAGTGQWITGFKIEGEISDVSWLRSGEGICVSNKYGGIWEWNILSQKVMSKWNDDSCYGITKISLGGFDDRWFALGSNTGIVNVYDRRNLSGELNNPSLYKTLNNLTTSINTLEFSPDGQILAMASKEKRDFLRLVHFPTGSVYKNWPTGSTPLGDVTVTKFSPSGSEIAIGNKSGKIGLWRFAYYYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQH4</accession>
    <name>M7NQH4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="3">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02295</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874290.1">
        <property type="nucleotide sequence ID" value="XM_007876099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQH4"/>
    <dbReference type="STRING" id="1069680.M7NQH4"/>
    <dbReference type="GeneID" id="19895988"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02295"/>
    <dbReference type="eggNOG" id="KOG2835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045637_0_0_1"/>
    <dbReference type="OMA" id="CEPFKVE"/>
    <dbReference type="OrthoDB" id="9991235at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01414">
        <property type="entry name" value="SAICAR_synt_Sc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000015">
        <property type="entry name" value="Phosphoribosylaminoimidazole-succinocarboxamide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010568">
        <property type="entry name" value="PRK13961.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR synthetase/ADE2 N-terminal" evidence="10">
        <location>
            <begin position="10"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="288" mass="33307" checksum="AD75B40EDE1D5DB0" modified="2013-05-29" version="1">MMVLEKYQKIIQGKVRDIYELDVDRLLFITSDRISAYDVVLKSEIPEKGKILTALSLFWFKKLGHICKNHLIDVNLPIELEKVRKNIEGRFMIVRKYQVLPIEAIVRGYLTGSAWKEYVKQGTVHGIPLRSGFKKGQALDMPLFTPSKKAKPGEQDENINPKEASNEIGEKYAEEMERLSLLLYKEAHIYAMERGIIIADTKFEFGVDTNGHLVLVDEVLTPDSSRFWICNSVDGEPYSLDKQYIRNWLEAENKAGQKDVILPESVIYQTRQRYIEVYEKLTGNTWTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQP0</accession>
    <name>M7NQP0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WDR5-like beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02364</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874369.1">
        <property type="nucleotide sequence ID" value="XM_007876178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQP0"/>
    <dbReference type="STRING" id="1069680.M7NQP0"/>
    <dbReference type="GeneID" id="19896057"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02364"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_1_1"/>
    <dbReference type="OMA" id="CKGHDTA"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000228">
        <property type="entry name" value="COMPASS-like H3K4 histone methylase component WDR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059122">
        <property type="entry name" value="Beta-prop_WDR5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25175">
        <property type="entry name" value="Beta-prop_WDR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR5-like beta-propeller" evidence="4">
        <location>
            <begin position="50"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="50"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="92"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="134"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="176"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="219"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="306"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="340" mass="37896" checksum="29941DA977966812" modified="2013-05-29" version="1">MDEDNQPLTKRIKPEKKLLISLDNTSTSVPDNCNFNIIPKISNYTLRYSLIGHKEPISSVKFSPDGKWLASSAADKLIKIWNALDGKFEQTLEGHLMGISDVAWASDSQSLASASDDKTIRIWNLMTGTTIKVLKGHTNYVFCINYNPQSNLIVSGSFDESIRIWDVKKGKCMKTLPAHSDPVSAVHFNRDGTMIVSCSYDGLIRIWDTATGHCLKTLVDDDNLPVSFVKFSPNGKYILASTLDSTHKLWNFHSGKCLKTYQGHINKRYCMLASFSVTGGKWIISGSEDNLIFIWDLQSKKVVQKLDGHSDVVVSVSTHPDHNIIASGSLDKTVNIYYDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQR2</accession>
    <name>M7NQR2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Inner centromere protein ARK-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00660</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INCENP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872560.1">
        <property type="nucleotide sequence ID" value="XM_007874369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQR2"/>
    <dbReference type="STRING" id="1069680.M7NQR2"/>
    <dbReference type="GeneID" id="19894358"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00660"/>
    <dbReference type="eggNOG" id="ENOG502S0AD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_278384_0_0_1"/>
    <dbReference type="OrthoDB" id="6123at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005635">
        <property type="entry name" value="Inner_centromere_prot_ARK-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142:SF1">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03941">
        <property type="entry name" value="INCENP_ARK-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inner centromere protein ARK-binding" evidence="9">
        <location>
            <begin position="1039"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="785"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="789"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1136" mass="129088" checksum="EE3BAF318C9DBC40" modified="2013-05-29" version="1">MKPLINEIGSSSWVFQEVKYLSDLSNEKLNDFALKIVENLEWINQYMEDVVKNCESTFCDYSKSGFVCSEAPLVSEKGSYFVCQENFGKESLLLKSLSFKLIPSPLKDLKENEFMDISENMDINYDDILSESEDSSLSIMESNEQNINLKYDSSSTRVMEMITEEDEVDEEVLDSVEIKVLSRNDDLETKFPCVLKKDNIVSPEEKSFKSDIEKSVKFKKDYDIVLENKDAISPLHDSDSLHHLDSKIMSGLDTGCTSTSIIHSYFSPPIDNTVNKVSFSPPTLSSSLNFVSLPPREPLNTKKSLGKRVSRHGSFSETVKSQKIVDSKLYEMLKQENQEDSSVLENRLSEDLQKQHISEGISGKKMVFDEIDKHDISEQRLKTVFTSGSQRIHEALSSLLITKPTSGHFKLASVEQKQQPDIETKIFEPENNLIAFNKVSNTINNVSSGECLHETASQIENEEYWVSKVDILNRPVVNTLMKQEKELPFHDINEIKNEPDSDEGLTAPNKLKDTSQRRTSIITIPAISVIGAIQAARNSATQAIRKATSVFFSPSSKAFPRNSIENAVERPLKVLNSSYDENTCLDSKRISDLKVNLEENNELSKNTTYKVEVEQPSNIIETKHNSIKACDYGQETNINKTRFLAKKSSALTSSISHEEVSLMANKFVSQELSCQNLKIQPSQPVKLTSFNSVSIAKNKPVSIRVTTASQRQADLAEKRKVQKTDFATSLQQSFASQTSQNQDNCSVTDSMQFNDSCSRELSVLSQSRSAKRLIPSKGIKALTAANLARKREQEEKDRKLAHKKEIERKRQENLKKQEENKKQEQWHREDLQRKVHSEKINDTKKKLLPQRLEHSSSVAKKICTISSDNNERGPLEDIINSDGKNRNTLNMEAKTFKRVLQDDLVQENWNSFSVSNKSLFQEVKKRKTDDISNESISNMPIHISSVKKDDKDPFVLRTQTREKGSCLNIQAMPQKHTRLLQSRYQGNQQISSSKSGKITGPIVDTVKFSTDNIRFGGESSKTVPVSHQYPQSESIELPEIDSDYSDDDELKKRFKTTLPQWAESPELTQILRMQAKIDPDKIFGPMKPLQMEEIFRGKDRAHMRFRSRSSSANWSGQDRLTEQEIENYAKIMGYKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NR52</accession>
    <name>M7NR52_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CDC20/Fizzy WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00790</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872694.1">
        <property type="nucleotide sequence ID" value="XM_007874503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NR52"/>
    <dbReference type="STRING" id="1069680.M7NR52"/>
    <dbReference type="GeneID" id="19894488"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00790"/>
    <dbReference type="eggNOG" id="KOG0305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014831_6_0_1"/>
    <dbReference type="OMA" id="CSGACLN"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033597">
        <property type="term" value="C:mitotic checkpoint complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000098">
        <property type="entry name" value="WD repeat-containing protein slp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF8">
        <property type="entry name" value="FI02843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="9">
        <location>
            <begin position="199"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="244"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="327"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="457"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="522" mass="57604" checksum="146A15210A3CFF3F" modified="2013-05-29" version="1">MLSTPMKHLDKNPICSTPTSGLKGQKSPLTPRQTAAIISHLHSVKRVYSPKSSIYRQTPLRLDVVTSDWTLVGTGPSSSPQKTTKRASFRLQCDRFIPQRTNQPSSATSKIIYPVIESKTGAQDTYNGTSNPSETIAYTASVAEACGLALNTRILAFKPSAPETSRPIDLRSQYNRPLKPAALSSQFRRRIVTAPERVLDAPGLIDDYYLNLLDWSNLNKVAIGLERNVYVWDADSGSVSCLMEAKQNTYVSGIKWSADGCYISIGLGDGDVQIWDIETSSKMRTMSGHEARVGVLAWDKHILSSGCRDGSIWNHDVRIAQHKVSEWKGHGSEVCGLEWRYDGSQLASGGNDNLVNIWDSRSSVPKFTKTNHIAAVKALSWCPWQLNLLCTGGGSQDRIIHFWNATTGARTHSVDTGSQVTSVRWSPVYRELVSSHGFPDNHLSIWQFPSLTKAIDIPAHESRVLHSCLNPDGQVLATAASDENLKFWRVFESTKKVSIDQMAGLSGNKSGLQEMTKTMTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NR89</accession>
    <name>M7NR89_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PRP1 splicing factor N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00827</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872734.1">
        <property type="nucleotide sequence ID" value="XM_007874543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NR89"/>
    <dbReference type="STRING" id="1069680.M7NR89"/>
    <dbReference type="GeneID" id="19894525"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00827"/>
    <dbReference type="eggNOG" id="KOG0495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007010_0_0_1"/>
    <dbReference type="OMA" id="DGWAWYY"/>
    <dbReference type="OrthoDB" id="440128at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000256">
        <property type="entry name" value="Probable pre-mRNA splicing factor prp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059164">
        <property type="entry name" value="HAT_PRP39_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010491">
        <property type="entry name" value="PRP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23241">
        <property type="entry name" value="HAT_PRP39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06424">
        <property type="entry name" value="PRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PRP1 splicing factor N-terminal" evidence="7">
        <location>
            <begin position="12"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR11238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="915" mass="103555" checksum="380EA5C79113231D" modified="2013-05-29" version="1">MSIRRDFLTAQAPENYVAGLGRGATGFTTRSDLGPAREGPSEDAIKAALARRAAAQHPFRFSSFQDSSDIKDDEDDDQYQDPENEYCLFAGAPYDADDEEADRIWSEVDQKMAQRRKSRREAKEREEAERLMERPKVQDQFADVIQGLSTITDDEWLNIPNVGDLTGKKRKKINPRERFYTIPDSLISRASQIEQLDTSIDVTETDTDFNDGKMTNFAEIGAARDKVLGLKLDQISSDSVTGQSTVDPQGYLTSINSMALKSNAELGDIKRARSLMQSLIKTNPNSAAGWMSAARVEIVAGKLQQARNIIAKGCENCPTNEDIWIEAVGLNNVQTGKIIIAEAVRHIPNSVRLWLQAINLETDIESKKRVIRKAIDIIPYSVKLWKEAVNLEEDPGNAKILLARATELIPLSTELWLALARLETYQNAKKILNKAQNTIKTSYEIWIAAARLEEQQGNDPDKVIANACRRLQQNGGMLTREQWLAEAEKSEKDGGIKTAQAIIKAILGQDLDEESKESTWINDAQNALSHECFECARAIYAYALKVFPKNESIWRKAISIEKSYGNVESVHAILEQALEECPQAEVIWLTYAKEKKKMGDIQGARDVLERSFLHNPNSEEIWLAAVKLEYINDENDRARALLKVARQEANTERVWVKSITFERQFNNMDVALSLVNEALTLFPNYSKFWMMKGQIYEDLGEVLKARETYQMGTKSVPKSVPLWILLSRLEENTGRIVIARGILDRARFLCPQTPELWVESIKLELRTNNINQAKSNIAKALQECPTSGLVWSEAVWIESRSQRKTRCADALRKCEDDPYILTTVARMMWNERKIAKAKIWFQRAIKSNPNVGDTWAWYYKFALQHESIEAQQSLVSECVAAEPSHGVVWPTVSKNIRNSKFTIEEILKNVAEKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRF1</accession>
    <name>M7NRF1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Serine/threonine-protein kinase TOR</fullName>
            <ecNumber evidence="12">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PNEG_00332</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="12"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872205.1">
        <property type="nucleotide sequence ID" value="XM_007874014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NRF1"/>
    <dbReference type="GeneID" id="19894030"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00332"/>
    <dbReference type="eggNOG" id="KOG0891">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000178_7_1_1"/>
    <dbReference type="OMA" id="MRQHSAK"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901992">
        <property type="term" value="P:positive regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000243">
        <property type="term" value="P:positive regulation of reproductive process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031137">
        <property type="term" value="P:regulation of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05169">
        <property type="entry name" value="PIKKc_TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000007">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.150:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000371">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000582">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000004">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.150">
        <property type="entry name" value="FKBP12-rapamycin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036738">
        <property type="entry name" value="FRB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026683">
        <property type="entry name" value="TOR_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01346">
        <property type="entry name" value="DUF3385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="14">
        <location>
            <begin position="1237"/>
            <end position="1787"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="13">
        <location>
            <begin position="1961"/>
            <end position="2281"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="15">
        <location>
            <begin position="2301"/>
            <end position="2333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMR11303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="2333" mass="267477" checksum="C4892A1C1B0DFC7E" modified="2013-05-29" version="1">MPSYSSKLDSLFSDLKNRNEEIRNKAANDLKEYVVSTSREMQRDAFISFNNDINRRIYELVHSNDNYERLSGVIVIDKLIDYDGEENTVKITRFANYLRIVLPGNDTQIMILASKALGRLAVPGGTLTSEFVEFEVKRAMEWLQGDRNENRRLAAVLVLKELALNSPTLIYSYVSQIFDLIWVALRESKVTTRNFAADALSASLEIIYQRESQLCIQWYVKILEEAQYGLKVNNYDYIHGSLLAYKELLLKSGTFMDEKYVDVCEVVLSYKDHKEALIRRTVVSLIPILAGYNPEKFVSSYLHKCMLHLLGQLKKNKDRTCPFSAIGHVAVAVGSSIEPYLDSILEIIKEGLTAKGRNREAQEAPIFQCISMLAIAVGNSLKKYLHELLDMMFCCGLSEPLRQALVDLTCHIPSFFPIIQERLLNLLSMILSGKPFKILGSPATLHSTQSNSLAIYDPKIYDNKDSEFIILALNTLGTFDFSGYALNEFIRDCAISYLESDNLEVRKVAALTCCQLFIRDPICYQTSNHAIQMVGEILEKLLIVGITDSDPMIRQIVLSSLDERFDRHLAQAENVRSLFIALNDEVFAIREITITIIGRLTFHNPAYVMPSLRKTLIQLMTELEYSYISRNKEENACLLGLLFSTAKRLIKPYVKPMLKIMIQKARDPSPSVVSSILNALGELAVVGGEDIIPHIPDLMPLIIEILQDQSSTAKRDAALRTLGRLAISSGYIIDPYIEYPSLLNILINILKTEQSSTVRKEAVKVIGILGALDPYKYQMLEETSEDHIHEQKAATSDVSLLIDGMSPSSEEYYPTVVINILMTILKDSSLSTYHYSAIQAIMYIFKTLGLKCVPFLPQIIPGFLSVMQTCLSSLLEFYFQQLSILVTIVKQHIRNYLSDIFKLIYDYWNSNSTLQITILSLVESIVMALEGEFKAYLPTLLSLMLQVLETDTTANRQSTQEILRSFVVFGSNIEEYIHLILPVVVKMFERHDLPISLRKIAIQTVAQLSRKINFVNHASRIIHPLARVLSTGTNELKVASMDTLCALVFQLGLDYTIFIPMINKCLINNHIQHQNYELLVSRLLKGESLPQDLNSDEKFSDRRMEDASSADINAKKLSVNQQHLKNAWETSQKSTKDDWQEWIRRLSVELLKESPSHALRACASLAAVYYPLSRELFNVAFLSCWNELCDQYQEELVKSIEIALTSPNIPAETLQSLLNLAEFMEHDDKTLPIDIRTLGAYAAKCHAFAKALHYKELEFISEPSTDTIEALISINNHLQQPDAAIGILSYAQQHNLELKETWYEKLERWEDALATYEKRSIEDNSFEVTMGKMRCLHALGEWELLSQLAREKWETATNDMRRSISPLAAAASWGLGQWELMDDYISSMKHESLDKSFFKAIISLHRNQFSETVFHIAKARELLDTEFTALIGESYNRAYYVAVRVQMLAELEEIIIYKQNNDHPEIQSTMRKTWMKRLNGCQRNVEVWQRMLKMKALVISPKENMEMWIKFSNLCRKSGRLGLAEKSLNSLLDTNGSIENFPSSTNVPPKVVYTHLKYMWETDDKRDALERLKEFSNSLSKDLKIASINETFRSLTLDQEKKNTYNDYSKLLSRCYHKQGEWQSVLQGNLSKTNISEILHSYKLATEYDPEYYKAWHSWALANFEVVAFYEKENKNLSPEIYDEHILPAIKGFFRSIALSTGNSLQDTLRLLNLWFKFGNHLQVGSSILEGIASVSIDTWLDVIPQLIARIHFPNSNIQKSIHQLLADVGKSHPQALVYPLTVASKSQNISRQKSALEIMDKIRNHSALLVEQALLVSHELIRVAILWHEQWHEGLEEASRLYFGDHNIEAMFNILEPLHEMLERGPETLREISFHQAFGRDLQEAREWCIKYRKTGEIGDLNQAWDLYYQVFRKITKQLPQLTTLELQYVSPKILSAVDLQLAVPGTYLSKKPIIRIISFSSTFTVITSKQRPRRLTIRGSDGKDYQYALKGHEDIRQDERVMQLFGLVNTLLSVDSESFKRHLNIQRYPVIPLSPNSGLLGWVPDSDTLHVLIKDYRESRKILLNIEHRLMLQMAPDYDNLTLLQKVEVFEYALDNTTGQDLYRVLWLKSKNSEVWLDRRTNYTRSLAVMSMVGYILGLGDRHPSNIMLDRHTGKAIHIDFGDCFEVAMNREKFPEKIPFRLTRMLTNAMEVSGIEGSFRITCEHVMRVLRDNKESLMALLEAFVYDPLVNWKLINTNPNSTTHRNEQNESSRISVKQNQENESTWKMQYRHEILNQSAVNVLNRVSNKLTGRDFKLNQELDIPSQVNRLIQQATSLENLSQCYIGWCSFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRL3</accession>
    <name>M7NRL3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dynactin subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00403</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872279.1">
        <property type="nucleotide sequence ID" value="XM_007874088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRL3"/>
    <dbReference type="STRING" id="1069680.M7NRL3"/>
    <dbReference type="GeneID" id="19894101"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00403"/>
    <dbReference type="eggNOG" id="KOG3958">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038287_0_0_1"/>
    <dbReference type="OMA" id="SDMDIQP"/>
    <dbReference type="OrthoDB" id="4977at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028133">
        <property type="entry name" value="Dynamitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15346">
        <property type="entry name" value="DYNACTIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04912">
        <property type="entry name" value="Dynamitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="97"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="353"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR11378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="46801" checksum="56ED93E44CA354FC" modified="2013-05-29" version="1">MALNDKYSTLPGLDTGKDVYETPDFVEDQWVESSIQFEREETQNEDISNDRLNLGQAKNRFLKEQVEAEDVDFSERIRGKSRKSYVTRNFHDYGVIEETIDEKLARLRRELEEVREELKHRKFQENKNENGPINKSFADLSELDYQIAELENQTKKSAIATLSRRLEELSLPESINNDNKEVVMETNESLNQPLKYTLNYNPSYKEKHFEPNLSEFENRLTMLEKSLGIDHIHSYKLQAPILSTLSYLDKKITLLTSNKSYIDSITKKVKDLVAEMEILHEKKTKMDSETSELNTTSQEKKINALYESLEMIESISPILPNLLDRLKALRIIHADAAAVTTGLKDCTQRQHIIQDEMIELKETLQKVESAMKESKMTIQSNMIEIENMVKELEQKVDHFENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRV7</accession>
    <name>M7NRV7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sepiapterin reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02012</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873992.1">
        <property type="nucleotide sequence ID" value="XM_007875801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRV7"/>
    <dbReference type="STRING" id="1069680.M7NRV7"/>
    <dbReference type="GeneID" id="19895706"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02012"/>
    <dbReference type="eggNOG" id="KOG1204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_11_1"/>
    <dbReference type="OMA" id="SHVDEWR"/>
    <dbReference type="OrthoDB" id="153074at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000281">
        <property type="entry name" value="Uncharacterized oxidoreductase YIR035C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF8">
        <property type="entry name" value="BENZIL REDUCTASE ((S)-BENZOIN FORMING) IRC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR09831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="28564" checksum="8391B0825A56DE05" modified="2013-05-29" version="1">MVLNKTILVTGASRGIGRAIVEELLESYKYIFVVAVVRSRSSLATLQEKFESRIAIVEGDLKDEKTNVRSVNVAIERFGRLDSLILNAAAIEPVGKIADIDVNSWKALFDVNYFSLLYILKSAIPYLRSFCGRVIFISSGASIKPYKSMGAYSGSKAAMNHLSSVLAAEESSITSISFRPGVVDTQMQTSLRENYSSNLDKDMHTRFMDLYQTGQLIPPEKIARIIVNLALNAKKELSGRFISYDDKELMEYEIHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRY4</accession>
    <name>M7NRY4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Palmitoyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00526</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palmitoyl-protein thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872414.1">
        <property type="nucleotide sequence ID" value="XM_007874223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRY4"/>
    <dbReference type="STRING" id="1069680.M7NRY4"/>
    <dbReference type="GeneID" id="19894224"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00526"/>
    <dbReference type="eggNOG" id="KOG2541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050129_0_1_1"/>
    <dbReference type="OMA" id="KFVMVMF"/>
    <dbReference type="OrthoDB" id="10263094at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000107">
        <property type="entry name" value="Palmitoyl-protein thioesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002472">
        <property type="entry name" value="Palm_thioest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF8">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02089">
        <property type="entry name" value="Palm_thioest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00414">
        <property type="entry name" value="PPTHIESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012158308" description="Palmitoyl-protein thioesterase 1" evidence="9">
        <location>
            <begin position="16"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="314" mass="36571" checksum="1F3762DFE32119ED" modified="2013-05-29" version="1">MFIYLWSVFFSFVFAVLQNKQEDSKKTLPVVLWHGLGDSYNSAEIMELSEILSETLNVYVHSIYLDKNPLSDRNNGFFGNVNEQIKLVAEQLSNDPKLADGFNAIGFSQGGLFLRAYIQRYNTPPVFNLITFGAPHYGISSFYCPSNVYVCKILDYFIKHSLLSYWVKENVIVAQYYRDTSDMNGYLEYNPFLPDINNEKEIKNATYAKNLGLLDSFVMVQFENDHVIIPKGSSHFNDYDKIEEKIIYLRETALYKEDWLGLKYLDDKKALVEMTIPGEHMEIGYETFIHIVKKYFVNSTRSEHIVQWQTKDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSB0</accession>
    <name>M7NSB0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">triacylglycerol lipase</fullName>
            <ecNumber evidence="6">3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Autophagy-related protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PNEG_01762</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="6"/>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873728.1">
        <property type="nucleotide sequence ID" value="XM_007875537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSB0"/>
    <dbReference type="STRING" id="1069680.M7NSB0"/>
    <dbReference type="ESTHER" id="pnemu-m7nsb0">
        <property type="family name" value="ATG15-related-lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="19895456"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01762"/>
    <dbReference type="eggNOG" id="KOG4540">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028295_1_1_1"/>
    <dbReference type="OMA" id="KEVITHV"/>
    <dbReference type="OrthoDB" id="58570at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034496">
        <property type="term" value="P:multivesicular body membrane disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046461">
        <property type="term" value="P:neutral lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050805">
        <property type="entry name" value="ATG15_Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175:SF2">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="19">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMR10006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="412" mass="46936" checksum="CBE075E179E8D550" modified="2013-05-29" version="1">MVFIATLKNISSVNLLNKPSYFTLKHVFTFGTCLYSYKYRFFNIKEGSEYDLLLYKRPFKILKKSMKIKRLRNNSRDLIREWFISSHYNNKSSVFFDWDFVNVDIPDIEDKQTVINMAEIASNAYIEIPNTGDWIDVGGGLDVIDDDSWNKSALHGHVFIDDQNKTVIIALKGTSPEVFGVYDPNTGMKDKINDNLLFSCCCGRISWIWTPVCDCFNGFYSCDERCLEKELLDESHYYMIALNIFYNVTKIYPKANVWMVGHSLGGALSSLVGLTFGLPTVTFEAPGEKLAAKRLHLPFPPGLPDNEAYVWHFGHTADPIFMGTCNGPKSTCWYGGYAMETHCHSGLSCIYDIIADKGWKMAIGTHRIKQVIDIIKDYKDVPKCNAYPDCMDCLEWNFYDSLLDTPSIKSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSF8</accession>
    <name>M7NSF8_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873778.1">
        <property type="nucleotide sequence ID" value="XM_007875587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSF8"/>
    <dbReference type="GeneID" id="19895503"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01809"/>
    <dbReference type="HOGENOM" id="CLU_1960497_0_0_1"/>
    <dbReference type="OrthoDB" id="5291082at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="128" mass="14970" checksum="686C30A576DDA0CA" modified="2013-05-29" version="1">MSDNNELPSYQASVSAKNKKELFDLLNLNESQIGAFSGTKCYKLFFWGILFPFPILLIGAYIGLIHYGFFKKNHFKDEQQQMYFEYVKEEEIKWGKRCFYLFGLISFVIASILLAGFKSNWTLSDYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSJ2</accession>
    <name>M7NSJ2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">mRNA 3'-end-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_00152</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the CPSF4/YTH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872013.1">
        <property type="nucleotide sequence ID" value="XM_007873822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSJ2"/>
    <dbReference type="STRING" id="1069680.M7NSJ2"/>
    <dbReference type="GeneID" id="19893850"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00152"/>
    <dbReference type="eggNOG" id="KOG1040">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024513_0_1_1"/>
    <dbReference type="OMA" id="FHQNNFA"/>
    <dbReference type="OrthoDB" id="1914176at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000012">
        <property type="entry name" value="cleavage and polyadenylation specificity factor subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045348">
        <property type="entry name" value="CPSF4/Yth1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102:SF24">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18345">
        <property type="entry name" value="zf_CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="13">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="13">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="13">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="13">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="14">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="173"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR11718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="245" mass="28164" checksum="5F182341BFC0FA77" modified="2013-05-29" version="1">MTSIINKVLKPDYSGSTFSFDHFLKTELRFNLDSNRPVCRFYIQGHCPLGNTCPDKHFFLKDGNSGRANSIVCKHWLRGLCKKGDQCEFLHEYNLKKMPECRFFAKHGFCSNGEECLYLHIDPDLKAGSCAWYTMGFCQLGPNCQQKHIRRTLCKLYLTGFCPKGPDCPNAHPKHVFPSHPSKQKGAPDSGAKEDVEERPYQNENVKERNERTYRDLSQVECFKCGQMGHYANHCYQSKAHNILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSV3</accession>
    <name>M7NSV3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like modifier HUB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01464</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873403.1">
        <property type="nucleotide sequence ID" value="XM_007875212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSV3"/>
    <dbReference type="STRING" id="1069680.M7NSV3"/>
    <dbReference type="GeneID" id="19895160"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01464"/>
    <dbReference type="eggNOG" id="KOG3493">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_156193_2_0_1"/>
    <dbReference type="OMA" id="GMSLEMQ"/>
    <dbReference type="OrthoDB" id="3881at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000753">
        <property type="term" value="P:cell morphogenesis involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033120">
        <property type="term" value="P:positive regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01791">
        <property type="entry name" value="Ubl_UBL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000052">
        <property type="entry name" value="Ubiquitin-like protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039732">
        <property type="entry name" value="Hub1/Ubl5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13042">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="73" mass="8550" checksum="7D47D73AE898263F" modified="2013-05-29" version="1">MIEIICNDRLGKKVRVKCNENDTVGDLKKLIAAQTGTNWQKIVLKKWYNTFKDHITLSDYEIHNGMSLELYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSX2</accession>
    <name>M7NSX2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01629</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873586.1">
        <property type="nucleotide sequence ID" value="XM_007875395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSX2"/>
    <dbReference type="STRING" id="1069680.M7NSX2"/>
    <dbReference type="GeneID" id="19895323"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01629"/>
    <dbReference type="eggNOG" id="KOG3501">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122140_0_0_1"/>
    <dbReference type="OMA" id="REMIQQK"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="70"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR10377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="118" mass="13602" checksum="1E8B14A65EB9B475" modified="2013-05-29" version="1">MSKLPDEVLKKILNEIQTQAIASQQHITTSQIQRQAKEKEKKISELIFNELSKLTRDTPVYSSAGKAFIKEDLNQIEQKLTTQIKEINNEIDALNKKIIYHETTLANTQPHIERIMNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NT57</accession>
    <name>M7NT57_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_01522</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873466.1">
        <property type="nucleotide sequence ID" value="XM_007875275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NT57"/>
    <dbReference type="STRING" id="1069680.M7NT57"/>
    <dbReference type="GeneID" id="19895217"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01522"/>
    <dbReference type="eggNOG" id="KOG1693">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066963_4_2_1"/>
    <dbReference type="OMA" id="VGEYTFC"/>
    <dbReference type="OrthoDB" id="1929172at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082408" description="GOLD domain-containing protein" evidence="10">
        <location>
            <begin position="17"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="28"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR10256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="206" mass="23973" checksum="A9CF7C7A93907F6F" modified="2013-05-29" version="1">MQWFFLIFAFIAIVKGTTLTIQLPPNKKQCFYTFVDEVGKKVIFYFAVRSGGSFDIDYQIFDTNKNIIFNGVKEKQGDIEFNAKYKGEYMFCFSNEMSTLTDKILDFQISVENEERAVLPQGGNNVNEQTETLDEYLLRISKVFSIIRHSQKYLNLRENRNLSTVQSTEARIFWFSITESILILIVSVLQVLILKTFFTSKTILKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7NT60</accession>
    <name>M7NT60_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH dehydrogenase [ubiquinone] iron-sulfur protein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-15 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase 15 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PNEG_01181</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFS5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873096.1">
        <property type="nucleotide sequence ID" value="XM_007874905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NT60"/>
    <dbReference type="STRING" id="1069680.M7NT60"/>
    <dbReference type="GeneID" id="19894878"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01181"/>
    <dbReference type="eggNOG" id="ENOG502S71X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162182_2_0_1"/>
    <dbReference type="OMA" id="SRCFAYW"/>
    <dbReference type="OrthoDB" id="9992197at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24141">
        <property type="entry name" value="NDUFS5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019342">
        <property type="entry name" value="NADH_UbQ_OxRdtase_FeS-su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15224">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15224:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10200">
        <property type="entry name" value="Ndufs5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR619342-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMR10467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="76" mass="8823" checksum="E46FFDB8F25FB3DF" modified="2013-05-29" version="1">MASGYGYSGGQSRCYPFWQQFLGCYASLDETKEKQVCIEEMEDYLECLHHAKEIRRLKAIQHEIERKASAKKDSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTC7</accession>
    <name>M7NTC7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">30S ribosomal protein S3, chloroplastic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">40S ribosomal protein S3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01245</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873166.1">
        <property type="nucleotide sequence ID" value="XM_007874975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTC7"/>
    <dbReference type="STRING" id="1069680.M7NTC7"/>
    <dbReference type="GeneID" id="19894942"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01245"/>
    <dbReference type="eggNOG" id="KOG3181">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058591_2_1_1"/>
    <dbReference type="OMA" id="NKKKWMI"/>
    <dbReference type="OrthoDB" id="10248446at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990145">
        <property type="term" value="P:maintenance of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02413">
        <property type="entry name" value="KH-II_40S_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.32:FF:000004">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000006">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_uS3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003219">
        <property type="entry name" value="PRK04191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="10">
        <location>
            <begin position="22"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR10537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="243" mass="27221" checksum="5484646CF0880496" modified="2013-05-29" version="1">MSNSLISKKRKFVADGVFFAELNELFTRELSAEGYSGTEVRVTPSRTEIIIRATHTQEVLGEKGRRIRELTSLIQKRFKFPDGTVELYAEKVQNRGLCAVAQCESLKYKLLAGLAVRRAAYGVLRFIMESGAKGCEVVISGKLRAARAKSMKFTDGFMIHSGQPARDFIDSATRHVLLRQGVLGVKVKIMLNEMITRKPLPDSVVVIEPKPEEHISQPSSEDFSRQLSSDLAQQTLYRVHPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTD9</accession>
    <name>M7NTD9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial import inner membrane translocase subunit TIM14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Presequence translocated-associated motor subunit PAM18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_01253</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TIM14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873176.1">
        <property type="nucleotide sequence ID" value="XM_007874985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTD9"/>
    <dbReference type="STRING" id="1069680.M7NTD9"/>
    <dbReference type="GeneID" id="19894950"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01253"/>
    <dbReference type="eggNOG" id="KOG0723">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_13_4_1"/>
    <dbReference type="OrthoDB" id="240298at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000001">
        <property type="entry name" value="Import inner membrane translocase subunit tim14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763:SF28">
        <property type="entry name" value="GEO10507P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR10547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="135" mass="15362" checksum="2C972D6CA09F27DF" modified="2013-05-29" version="1">MVAGIILGSIGVATVATLIGLGLRTFQKYKLFPRGASSQHIYKGGFHKQMSCREAALILSLKYVFKLKNDFFYFNKLFICINIIYSENTLTRSKLKDAHRRIMLLNHPDRGGSPYIASKINEAKDLLEKQRNLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTN3</accession>
    <name>M7NTN3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873095.1">
        <property type="nucleotide sequence ID" value="XM_007874904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTN3"/>
    <dbReference type="STRING" id="1069680.M7NTN3"/>
    <dbReference type="GeneID" id="19894877"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01180"/>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1611471_0_0_1"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948:SF10">
        <property type="entry name" value="MRJ, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="6"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="165" mass="19808" checksum="B387F9EB651A2920" modified="2013-05-29" version="1">MALLRSPYETLSLERTATKEEIRRAYRREALANHPDKVPAERRAAAEHRFKEVKEAYEVLYDDNKRRLFDMYGLACAPPETVQERSVNVHMNDLGADWFMSAHEQFIQHMFPQQTMQSFFSQFHAFPRFSRNISTSIFDDISFMNRYMDPFDFFDEIFADPWFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTQ0</accession>
    <name>M7NTQ0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translocation protein SEC72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873281.1">
        <property type="nucleotide sequence ID" value="XM_007875090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTQ0"/>
    <dbReference type="STRING" id="1069680.M7NTQ0"/>
    <dbReference type="GeneID" id="19895048"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01351"/>
    <dbReference type="eggNOG" id="ENOG502S442">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090376_2_0_1"/>
    <dbReference type="OMA" id="KMYTLAI"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="22611" checksum="C40356F97278897A" modified="2013-05-29" version="1">MSFFDTFVQLPISINEGRVVSVEKELMEKLEPFNRLIKSITLNQYPEDIPLPPNQVHPKRSIHINRLKESGTEHSRRKNYDEALKFFTLAVEMAYGRPYWEPASLSRDELAAAFYERCTVYLASKQWKNAFVDASTVIGIRKAWSKGHLCKSKALQGMGILDKAKESLELGLSFEPKNDELLAALKELNRQLERYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTV0</accession>
    <name>M7NTV0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872757.1">
        <property type="nucleotide sequence ID" value="XM_007874566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTV0"/>
    <dbReference type="STRING" id="1069680.M7NTV0"/>
    <dbReference type="GeneID" id="19894546"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00848"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_771879_0_0_1"/>
    <dbReference type="OMA" id="WDINTRE"/>
    <dbReference type="OrthoDB" id="1517790at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF46">
        <property type="entry name" value="LEUCINE RICH REPEAT-CONTAINING DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="359" mass="41541" checksum="419B43760061DDF3" modified="2013-05-29" version="1">MNPLLPFSTILSREKSYEFGSYSKRDYISNTEKFRKICSLNDPNRFNLKREHDYEYEEDLLVEQPYVHIQYHQRNKDFNKKRRDLTPISLFNEAITNAIEEGEEVLQLSECNIVEIPENISELTSLVRRLDPENEKPLIPRLKIFLSGNMIYKLPSGLFDLFTLTVLSLRNNDLKMIPSSIGRLVNLVELNLGQNKLTYFPSTLLFLKKLQILSISPNPLRDCPIAYSSQTSFQSLTSPVLRYSCVDLIKTDSNVPKLLELSARVIASSLIAKSDIQKWETKFCFIPKIKKAYEAGKYHISCEICQKPMVDSDVDVFEWWDGFVGTWSLPIKRKICSLLCFKNIPRVETPFSSDESQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTV1</accession>
    <name>M7NTV1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01249</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873170.1">
        <property type="nucleotide sequence ID" value="XM_007874979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTV1"/>
    <dbReference type="STRING" id="1069680.M7NTV1"/>
    <dbReference type="GeneID" id="19894946"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01249"/>
    <dbReference type="eggNOG" id="KOG4086">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071681_3_0_1"/>
    <dbReference type="OMA" id="YWSRPPY"/>
    <dbReference type="OrthoDB" id="10257739at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006311">
        <property type="term" value="P:meiotic gene conversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1340">
        <property type="entry name" value="Mediator of RNA polymerase II, submodule Med31 (Soh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038089">
        <property type="entry name" value="Med31_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008831">
        <property type="entry name" value="Mediator_Med31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13186">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05669">
        <property type="entry name" value="Med31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0010">Activator</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="127" mass="15358" checksum="B93216F799171AE5" modified="2013-05-29" version="1">MNNNDDILDDVFELRRFEQELEFIQCLASPWYLNFLAQSKYLSCPVFLNYLKYLEYWRRPEYAQFLTYPICLYHLTLLNDEQFRIDISREDLARRMNDEIYYQWLDGQLSTNEVDIKMNDSGVIGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NU27</accession>
    <name>M7NU27_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peroxidase</fullName>
            <ecNumber evidence="14">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PNEG_00915</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 Fe(II)-[cytochrome c] + H2O2 + 2 H(+) = 2 Fe(III)-[cytochrome c] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.11.1.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Forms a one-to-one complex with cytochrome c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="14"/>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872827.1">
        <property type="nucleotide sequence ID" value="XM_007874636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NU27"/>
    <dbReference type="STRING" id="1069680.M7NU27"/>
    <dbReference type="GeneID" id="19894613"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00915"/>
    <dbReference type="eggNOG" id="ENOG502QR1E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036959_1_1_1"/>
    <dbReference type="OMA" id="QRKWNGP"/>
    <dbReference type="OrthoDB" id="2859658at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004130">
        <property type="term" value="F:cytochrome-c peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00691">
        <property type="entry name" value="ascorbate_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000009">
        <property type="entry name" value="Ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000005">
        <property type="entry name" value="Cytochrome c peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF58">
        <property type="entry name" value="CYTOCHROME C PEROXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 14" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="16">
        <location>
            <begin position="149"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMR10767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="350" mass="40038" checksum="9FA1C9A0C3951B92" modified="2013-05-29" version="1">MFLKQGFSVFQASARLSISTVRNSTRRLYFTTTKSPSKGFLYGGIVLGASLLGCGYYYYNYGMDSFDFLITKNKDQKNYHKVYREIAELMNSEELEDYDDGSLGPILVRLGWHSSGTYNKEDNSGGSNGATMRFEPESKHLANAGLHVAREALEKIKKKNPWISYSDLWTLAAVCAIQEMSGPSIPWRPGRVDGDSTRCPPDGLLPDASKEQSHLRNIFYRMGFNDQEIVALSGAHALGQCHPDRSGYTGHWTFSPTVFTNDYYKMLLNEKWDYKKWDGPKQFEDKTKSLMMLPTDISLIKDKEFKKYVELYAKDEKKFFEDFSKAFSKLLELGVPHFDQEPIIFKHIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUN2</accession>
    <name>M7NUN2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 5A</fullName>
            <shortName evidence="8">eIF-5A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00617</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eIF-5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872515.1">
        <property type="nucleotide sequence ID" value="XM_007874324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUN2"/>
    <dbReference type="STRING" id="1069680.M7NUN2"/>
    <dbReference type="GeneID" id="19894315"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00617"/>
    <dbReference type="eggNOG" id="KOG3271">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102600_0_0_1"/>
    <dbReference type="OMA" id="AKCHFTA"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006452">
        <property type="term" value="P:translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04468">
        <property type="entry name" value="S1_eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000007">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000034">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 8" id="KW-0385">Hypusine</keyword>
    <keyword evidence="10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="9">
        <location>
            <begin position="85"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="156" mass="16920" checksum="B6BE0DA7E49A4923" modified="2013-05-29" version="1">MAENLETNFSNIDSGGSSTFPVQCSALRKNGYVVIKGRPCKIVDMSTSKTGKHGHAKVHLVGIDIFTGKKLEDLSPSTHNMDVPIISRQEYQLINVDDGYLNLITSDGSTKDDIRLPEGELGEKIISEFEEGKDLLVTVVSAMGEEVALAVKEAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUU2</accession>
    <name>M7NUU2_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01018</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872931.1">
        <property type="nucleotide sequence ID" value="XM_007874740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUU2"/>
    <dbReference type="GeneID" id="19894716"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01018"/>
    <dbReference type="eggNOG" id="ENOG502S7KP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083683_3_1_1"/>
    <dbReference type="OMA" id="HRPINPE"/>
    <dbReference type="OrthoDB" id="2351920at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008401">
        <property type="entry name" value="Apc13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28526">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28526:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05839">
        <property type="entry name" value="Apc13p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="113" mass="13294" checksum="530C74046B1B3876" modified="2013-05-29" version="1">MDSQRSYIHFNQPRIVDYIEKWCADKLPDDDIIVAPQHQPPHPDDDDVPNQQTMNGILRAQKPSEPAWRDLGLQELMTRGPSEELQNHIEQRLKEIQQNFRPQTLDRQNSHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NV61</accession>
    <name>M7NV61_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">RRN7-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_00616</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRN7/TAF1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872514.1">
        <property type="nucleotide sequence ID" value="XM_007874323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NV61"/>
    <dbReference type="STRING" id="1069680.M7NV61"/>
    <dbReference type="GeneID" id="19894314"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00616"/>
    <dbReference type="eggNOG" id="KOG0003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016553_2_2_1"/>
    <dbReference type="OMA" id="ICRDIWA"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048538">
        <property type="entry name" value="Rrn7_cyclin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048540">
        <property type="entry name" value="Rrn7_cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033599">
        <property type="entry name" value="TAF1B/Rrn7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021752">
        <property type="entry name" value="TF_Rrn7_Zf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576:SF2">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20645">
        <property type="entry name" value="Rrn7_cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20644">
        <property type="entry name" value="Rrn7_cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11781">
        <property type="entry name" value="Zn_ribbon_RRN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRN7-type" evidence="10">
        <location>
            <begin position="11"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Rrn7/TAF1B N-terminal cyclin" evidence="11">
        <location>
            <begin position="86"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Rrn7/TAF1B C-terminal cyclin" evidence="12">
        <location>
            <begin position="223"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR11016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="58266" checksum="2BE8835E06EB3CCA" modified="2013-05-29" version="1">MNQYQFNQDSRCGIDNCTSKQFYIDAGLTYCINGHLVQGIIEIDNTSNLNKNQPLRRRKVITSDKHKKKSKVLYGNEGKNLFLHCFQQILKTQVWCLIHTHGISKNLEPTVRNIWKIYLTLLTSNKLFQKNTKKKIKYHNNSIQGNSNDNISYKITRFPKLIDTISICYLGLLNLRSIITISTLYNFMKSGKVPYMQTSSIIPLEIRKCMEPQYQNTLSPTVFPSYEKVLNVTYSIFSAFYIFYKIVFPPLNIYPILVTYIQGLHLPLELILPTLKLAYQLNISFTNQQLLEETNLNTMPEVILLAVLLISTRLYFQIDHYDIENFKDYTYNNLKDWNIWLSIMNSRNYNKLANFGYTKTDINKISQISKEEINNYLNDLSIQLSNSSYIKVPKFLLNIFPINELKKTNEYFNSTHNYYTSLESYNTKSYTTNTIFRNRKLIYKIFSLSSTLPNITKTLISKGAEMIGITEFKLRKIILILEKQYIYLNDNCKLENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVB7</accession>
    <name>M7NVB7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872578.1">
        <property type="nucleotide sequence ID" value="XM_007874387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVB7"/>
    <dbReference type="STRING" id="1069680.M7NVB7"/>
    <dbReference type="GeneID" id="19894378"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00680"/>
    <dbReference type="eggNOG" id="KOG3872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_691025_0_0_1"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22679">
        <property type="entry name" value="FHA_SLMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051176">
        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF37">
        <property type="entry name" value="LD47843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="32"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="276"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR11081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="399" mass="45759" checksum="7FCC8F36D05833E3" modified="2013-05-29" version="1">MVDSSSVCLILAPLNDTFERKCLWLPSWPQTLRIGRQINSRTTPASNNGFFDSKVLSRAHAEVWADPKTGRVFIRDIRSSNGTFLNGRRLSQENQTSEPFELYIGDVLELGIDILNEEDRSILHCKVSSRVEHAGWAEANSSDVSQAEINALWVDTGTAETFDTITPRVLVSNDPVHSKSVLEENKIHECFGKEMEDILQTLNIGLKTAKQQINDIKLITKVLNNIQDTVFYDSRNDSLEKIQSEDISKNHSENFESKGNFGLYKKRMQPPSLEVLASKQLEIEEKTAKIKRLEEEKTKQQTYKQIIEHLLKEQNNTLEMENTIETKMNIELMKSKLGKDQNSEDELKSLKAMVETMKKEVELWKYRAKRTEKIVEQSTYHMAALLKTENESNINEHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVL7</accession>
    <name>M7NVL7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U3 small nucleolar RNA-associated protein 11</fullName>
            <shortName evidence="6">U3 snoRNA-associated protein 11</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00779</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Nucleus</location>
            <location evidence="2 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UTP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872682.1">
        <property type="nucleotide sequence ID" value="XM_007874491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVL7"/>
    <dbReference type="STRING" id="1069680.M7NVL7"/>
    <dbReference type="GeneID" id="19894477"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00779"/>
    <dbReference type="eggNOG" id="KOG3237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061887_0_2_1"/>
    <dbReference type="OMA" id="DLKYVVM"/>
    <dbReference type="OrthoDB" id="29058at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03998">
        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015952">
        <property type="entry name" value="U3snoRNP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR11186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="257" mass="30643" checksum="FCB3DA4FDFBB9FFA" modified="2013-05-29" version="1">MGTLKHSLQRRNHKERSQPVEREKWGLLEKPKDYRLRARDYQSKQHRLKRLREKAAEKNPDEFYFGMMKEKTKDGIVIVDRGNPVLTEETVRLLKTQDAGYIRMMLNIENKKVKKLEQYVYTNNQETTNCNAKHYCFVDETNLESQEKKYQKQKKIDYTGQVQEKLSEEPFVHDDSVETYSNLVNEDQAIQISKVTLSVDPKLIRELTLRKNRIEKLSILTRQINLQRNLQTKGERKKIGTTSDGIPIYRWKLERKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>M7NW11</accession>
    <name>M7NW11_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PNEG_00510</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872398.1">
        <property type="nucleotide sequence ID" value="XM_007874207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NW11"/>
    <dbReference type="STRING" id="1069680.M7NW11"/>
    <dbReference type="GeneID" id="19894208"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00510"/>
    <dbReference type="eggNOG" id="KOG1027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004875_2_1_1"/>
    <dbReference type="OMA" id="IRYYCSE"/>
    <dbReference type="OrthoDB" id="63989at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140501">
        <property type="term" value="P:positive regulation of reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10422">
        <property type="entry name" value="RNase_Ire1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13982">
        <property type="entry name" value="STKc_IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000077">
        <property type="entry name" value="Putative Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000572">
        <property type="entry name" value="Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.180">
        <property type="entry name" value="KEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010513">
        <property type="entry name" value="KEN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038357">
        <property type="entry name" value="KEN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="IRE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954:SF6">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06479">
        <property type="entry name" value="Ribonuc_2-5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00580">
        <property type="entry name" value="PUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51392">
        <property type="entry name" value="KEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="410"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="579"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="KEN" evidence="21">
        <location>
            <begin position="878"/>
            <end position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EMR11497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1009" mass="118821" checksum="30532ABD494B8CA5" modified="2013-05-29" version="1">MDIVYENFYEKFFNSIEWPSKSHLISKDLSGLSFTDLALLVTTDGDLYGINRDDGEINWIIKGLNSIIKSERNLVKIDNLSEDYIQRISNNVDFFWFLEPAGDGSIYIFDFRIGIHKFPFNIKQLIKLSPYSFPGDDKVYIGKKETSLFVVNVNTGKIYQSFGSGHEYDDAFHCFSNEVFGESYDKQCNFSDFDDKNVLKIGRIDYILNVYSGNRLLWNVSYSEWVPSFINVNFENKYFSMFDGKYILSTHNGAVFQRNITGTTSSIIWSKKLDSPVTKVFDILSFTPISIYQQSELDNQHTFIMVEQPTDFIFKMFNRTYNRYVFINTTQIGNWYALSEEKFPLIKEASLSQWYNATINFGKLGILPLHKDLIGLHKISYDVAQILTIDSSLEPLKIDYFLDKSYNLKYRYIFYIFFVIGLLIYFSWRWGFYQFILWLKVKFFTCIIYVKKKNIQQFLVNILTIFGRKKNKEYENVFENFNEIVLNDDNILFSKDENLKMLHLKKRKKTVRKNKKYKKVIENMSCVDTAEEMSENEYFKNKIEYHNNNLENSSLDLFEFKAYDSIEKIEFPLVINSLEITNKILGYGSHGTIVYEGSFEGRKVAVKRILLDFYEVAFREITLLQESDGHPNVIRYYCKQKSDKFLYIALELCSASLYDIIERSHEFSWLLMSMNVSDILYQIASGIQYLHSLKIIHRDIKPQNILVAPLYANSDNNKDGEQVNRVRIMISDFGLCKKLEFDQNSFKVTTSQLSGTIGWRAPELFYEKMNVDKFQENISDLEIKSLSSFQNHKVGRAIDIFSMGCVFYYVLTNGMHPFGEYYLREGNIVKGTANYSHLDFLGNESFLAKDLISKMLNLDPKKRPDAEFVVKHPYFWSSEKKLSFLIDTSDRFETERRQSPSELLQFLEKDVLKIIGRNWLKKINKHILENPGRFRKYDGTKLLDLLRILRNKKNHYQNLPLHIQEILGPPPDLYLSYFMTRFPYLLLHCYYIVKRFLDKENMHQLASYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NW30</accession>
    <name>M7NW30_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00355</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the REI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872228.1">
        <property type="nucleotide sequence ID" value="XM_007874037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NW30"/>
    <dbReference type="STRING" id="1069680.M7NW30"/>
    <dbReference type="GeneID" id="19894053"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00355"/>
    <dbReference type="eggNOG" id="KOG2785">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018787_1_0_1"/>
    <dbReference type="OMA" id="WTQTQQQ"/>
    <dbReference type="OrthoDB" id="19329at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF8">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="390" mass="46099" checksum="0B5D01AA734FE693" modified="2013-05-29" version="1">MKSPMFTCILCKVTFQSSDVQRVHYRSEWHLYNLKRKMAGFSSVSAHCFSQKMVSEVWNEKKEEKERFNGKKKKKEKKNGFNVENESYLLNKSEEAIELNKKQYINEPDLKKSEEIMANLCNPIYLNSTSYEKMELNESEEKLIKEHIAKATKLKITDCLFCTFKFSTLNENLEHMKKSHSLFIPEQEYLIDLKGLIEYLGEKISIGNVCLSCKKVGKSLESIRQHMFSKGHYSIAYDTEEERLELSDYYDYGSYSAKDNDSDWEDISSNQDKDDILSIYSDNDDDVIIENDYELILPSKIRLGHRSLIRYYQQNLRSRNFQRQSGDRNPSGLVRQEYVQRSLKGIDQSKRKFSEKHIRTYQDVFQKENYKTAIGLKSNHQKYFRNELLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>M7NW50</accession>
    <name>M7NW50_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein kinase</fullName>
            <ecNumber evidence="8">2.7.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_00380</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.21" evidence="8"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872253.1">
        <property type="nucleotide sequence ID" value="XM_007874062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NW50"/>
    <dbReference type="STRING" id="1069680.M7NW50"/>
    <dbReference type="GeneID" id="19894078"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00380"/>
    <dbReference type="eggNOG" id="KOG0575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_46_2_1"/>
    <dbReference type="OMA" id="IQIHKSM"/>
    <dbReference type="OrthoDB" id="408964at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090619">
        <property type="term" value="C:meiotic spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035974">
        <property type="term" value="C:meiotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140602">
        <property type="term" value="C:nucleolar peripheral inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019237">
        <property type="term" value="F:centromeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051219">
        <property type="term" value="F:phosphoprotein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010458">
        <property type="term" value="P:exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031619">
        <property type="term" value="P:homologous chromosome orientation in meiotic metaphase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990571">
        <property type="term" value="P:meiotic centromere clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990813">
        <property type="term" value="P:meiotic centromeric cohesion protection in anaphase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090306">
        <property type="term" value="P:meiotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990395">
        <property type="term" value="P:meiotic spindle pole body organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904750">
        <property type="term" value="P:negative regulation of protein localization to nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045793">
        <property type="term" value="P:positive regulation of cell size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140281">
        <property type="term" value="P:positive regulation of mitotic division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140429">
        <property type="term" value="P:positive regulation of mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010696">
        <property type="term" value="P:positive regulation of mitotic spindle pole body separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046827">
        <property type="term" value="P:positive regulation of protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110083">
        <property type="term" value="P:positive regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031031">
        <property type="term" value="P:positive regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903353">
        <property type="term" value="P:regulation of nucleus organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902542">
        <property type="term" value="P:regulation of protein localization to mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051455">
        <property type="term" value="P:spindle attachment to meiosis I kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070194">
        <property type="term" value="P:synaptonemal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13117">
        <property type="entry name" value="POLO_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14099">
        <property type="entry name" value="STKc_PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001669">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033695">
        <property type="entry name" value="POLO_box_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000959">
        <property type="entry name" value="POLO_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00659">
        <property type="entry name" value="POLO_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50078">
        <property type="entry name" value="POLO_BOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="80"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="11">
        <location>
            <begin position="519"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="11">
        <location>
            <begin position="627"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR11351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="715" mass="81739" checksum="33BBC36EFE620624" modified="2013-05-29" version="1">MPIQTISANGEVGNLRVSPYDKYKLLDSNDQDMSGSKEVVNKGNNSISQPLKQVNNNTKPSNLCFTPPVQITDKKKGREYTRSILLGEGGFARCFLVTNGRGSRFAAKVIAKTTLRSMKNRTKLFGEIKIHQSMDHPSIVKFIDCFEDATNVYLILELCENKTLMDMLRKRKRFTEPECRFFLLQVLGAVKYMHSRKVIHRDLKLGNLFLDENMNIKIGDFGLAALLISDDERKKTICGTPNYIAPEVLFGKQDGHSFEVDLWAVGIIMYAMLIGKPPFQSKEVKAIYKNIRENRYVFPENIPISLEAKDLIGSLLDTDPLNRPCIDEIAEHPFFHIGYLPTEIPVQALLQEPVWPEDSLSIKRSQGSWNTIASWCGIGKGRNIGGKEGQTVSMVMEVLENENILPTSLSCDTHSRAVMKVAKPVNSKSDLFKRPKCSFIDRKENLNPQDFMKPVIDMTSKMAIKESYVSNEVKDMELSSNVWQSLRNIALNLDCALRLRSKRMPPEFYDASTTTSPLFINKWVDYSNKYGLGYQLSNGSIGVYFNDSTTLILSNNEYHFDYITQSGKNGFKRRSFTIEKFPSNELDKKVYLLKYFKKYMIQNLFKAEAWSCNVDDFQSIGVKSMSFMTNYFRTKHAIIFRLSNQSVQFNFVDHCKLILSDNGRIVRFIDSKREFHTWSLGNALEPGLCDDNVSEKFKFAKEVLLSWADKMESYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NW66</accession>
    <name>M7NW66_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00555</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872448.1">
        <property type="nucleotide sequence ID" value="XM_007874257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NW66"/>
    <dbReference type="STRING" id="1069680.M7NW66"/>
    <dbReference type="GeneID" id="19894253"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00555"/>
    <dbReference type="eggNOG" id="KOG0941">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1533197_0_0_1"/>
    <dbReference type="OMA" id="MHSSANH"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF8">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="6">
        <location>
            <begin position="36"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="175" mass="20803" checksum="ECDEA198B8CA23E9" modified="2013-05-29" version="1">MLFFTIFQKWPITPYLILRVRRECIIDDNLRQVSNNEIDLKKRLKIEFIGENGIDIDGLRKKCIILDKSIMINILEMFTWSEKVNYYWFNPTSFESLVQYYLVGVILGLAIYNSTILDVYFPLACYKKLLDILYELDDLKNFRPGLIEGFQYLLAFDDNVEDIFCRDFVGEYEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7NW93</accession>
    <name>M7NW93_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00429</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the U5 snRNP complex required for pre-mRNA splicing. Binds GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872307.1">
        <property type="nucleotide sequence ID" value="XM_007874116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NW93"/>
    <dbReference type="STRING" id="1069680.M7NW93"/>
    <dbReference type="GeneID" id="19894127"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00429"/>
    <dbReference type="eggNOG" id="KOG0468">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_11_2_1"/>
    <dbReference type="OMA" id="YIFRPIR"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04098">
        <property type="entry name" value="eEF2_C_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04090">
        <property type="entry name" value="EF2_II_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01683">
        <property type="entry name" value="EF2_IV_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16264">
        <property type="entry name" value="snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04167">
        <property type="entry name" value="Snu114p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000004">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000029">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000009">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000001">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000646">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031950">
        <property type="entry name" value="EFTUD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044121">
        <property type="entry name" value="Snu114_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035655">
        <property type="entry name" value="U5-116kDa_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF6">
        <property type="entry name" value="116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16004">
        <property type="entry name" value="EFTUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="131"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="974" mass="109846" checksum="5CD996C7D4E7BEB0" modified="2013-05-29" version="1">MDETLYDEFGNYIGKAESEEEEQETVENANGAYLNDEEIGLVEAYLSDDELEEIPQAKQAIVLHEDKQYYPSASEVYGPDVEILVHEEDTQPLSEAIIQPIKVKKFSLEEMDFPATHYSKEFMINLMSFPEFVRNIALVGNLHHGKTSFLDMLIHETHDIKTESKKMLKYSDVHILERDRGLSIKATPMSLVLQNTKGKSFLFNIIDTPGHVNFVDEVASSIRLVDGAILIVDAIEGVLVNTDKIVRYSVLENIPFVLVINKVDRLILELKLPPADAYFKLRHTIEEINSIIKSCSTNDYRLSPEKGNVCFASTDMNWCFSLFSFAKMYADTYDGVNIDDFSQRLWGDIYYNPQSRNFTRKSVEQDAKRTFVHFILEPLYKLYGQTLGEPPEVLDKTLKSLGIFLKPAQFKLDSKALLKLICGEFFGTATGFVDMVIKHIPSPIDGSVAKIHHTYTGPLDSEIAQNMLKCDPNGHLVIHTTKLLNTIDATEFFSLGRVMSGTIHSGDQVKVLGENYSIDDEEDMVYATVSGVWVGGARYRIPVNSAVAGSIVLLAGVDNSILKTATIVSRDIQDDIYIFRPVKHFTESVFKVAVEPVNPSELPKMLSGLRMINKSYPLSVIKVEESGEHIIFGTGELYMDCILHDLRKLYSEIEIKVSDPIVKFCETVVETSAVKCYASTPNKKNKITMIAEPLDDGIAEDIETGKVNIKWPIRKVGEFFQKYQWDILASRSIWAFGPNEQGPNVLLDDTLPSEVDKKLLNTVRDSIRQGFQWGTREGPLCEEPIRNVKFKILDVTLATEPIYRGGGQIIPTVRRTCYSSFLMATPRLMEPIYYVEIQAPADCISAVYTVLGRRRGHVTQDIPKAGSPLYTIKALIPIIDASGFETDLRTHTQGQAFCQQIFDHWQVVPGDPLDKTCVLQLFEPASGQSLARDFMLKTRRRKGLVEDVVISKYLDEEMMMILAQTDILKDNFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWE6</accession>
    <name>M7NWE6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SAGA-associated factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_00486</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the SGF11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872372.1">
        <property type="nucleotide sequence ID" value="XM_007874181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWE6"/>
    <dbReference type="STRING" id="1069680.M7NWE6"/>
    <dbReference type="GeneID" id="19894184"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00486"/>
    <dbReference type="eggNOG" id="ENOG502RAWA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1511204_0_0_1"/>
    <dbReference type="OMA" id="CHFYSIN"/>
    <dbReference type="OrthoDB" id="21557at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071819">
        <property type="term" value="C:DUBm complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013246">
        <property type="entry name" value="SAGA_su_Sgf11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051078">
        <property type="entry name" value="SGF11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46367">
        <property type="entry name" value="ATAXIN-7-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46367:SF1">
        <property type="entry name" value="ATAXIN-7-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08209">
        <property type="entry name" value="Sgf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="127"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU261113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR11471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="178" mass="19926" checksum="A13C49F0F48DEB89" modified="2013-05-29" version="1">MKTVKLNKDSLAGLSFSILSDLLLDIIFEIAVSTHKREVFSKRKCLRCNKFCHFYSINSGSDIFGKPYQTPVTAPYYSCTICSREIAAGRYVPHLEKCLGSGRLSNRLAHQKTNGYGTSISSCTNNVENDISSEDETQHRKKRRRPTNGSTKYGSTKSHLKLKKPLITSNNSDVDLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWJ1</accession>
    <name>M7NWJ1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872422.1">
        <property type="nucleotide sequence ID" value="XM_007874231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWJ1"/>
    <dbReference type="GeneID" id="19894230"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00532"/>
    <dbReference type="HOGENOM" id="CLU_2905156_0_0_1"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="62" mass="7028" checksum="7EB5BFDBE42A376C" modified="2013-05-29" version="1">MSSSTNKQSSKNIYSHLRRIPLELYPLAAVLLVGFGAATYQLGNKLFFDPSLRRYPSKKSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NX55</accession>
    <name>M7NX55_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pyridoxal kinase</fullName>
            <ecNumber evidence="2">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00175</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872036.1">
        <property type="nucleotide sequence ID" value="XM_007873845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NX55"/>
    <dbReference type="STRING" id="1069680.M7NX55"/>
    <dbReference type="GeneID" id="19893873"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00175"/>
    <dbReference type="eggNOG" id="KOG2599">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046496_1_0_1"/>
    <dbReference type="OMA" id="HTQYGQW"/>
    <dbReference type="OrthoDB" id="2104723at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00687">
        <property type="entry name" value="pyridox_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="7">
        <location>
            <begin position="85"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR11741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="322" mass="36068" checksum="A3B205C02358E75F" modified="2013-05-29" version="1">MSNLSFKKILSIQSNVSSGYCGNRCATFPLQLLGFEVSTIHTVQFSNHTGYGRWRGQVFKGQHIMDLFEGLKENGFTKEFDFLLTGYVRGKEGIETITNIIKDLKTTNPEIGWLLDPVLGDERGFYVSPDVIPTYKQLIPMSDLITPNQFEAELLSGQKITSIESLMICLERLHKNHTLKHVVITSVQFDNDKEHLYVIGSSCKSDYTPRAVKITVPYYKQVFSGVGDLFSALLLGRLNNDIKLFPSDEIPATSLPLTIALEIVVSSVQLVIRNTLKSIQDASVDQDKLSKVEMAKLSELRIIQSQDCLKNPSIEFKAVVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7P2D0</accession>
    <name>M7P2D0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_03482</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875572.1">
        <property type="nucleotide sequence ID" value="XM_007877381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P2D0"/>
    <dbReference type="STRING" id="1069680.M7P2D0"/>
    <dbReference type="GeneID" id="19897169"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03482"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003789_0_0_1"/>
    <dbReference type="OMA" id="YCEMNDI"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057334">
        <property type="entry name" value="PH_2nd_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051279">
        <property type="entry name" value="PP1-Reg/Actin-Interact_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25353">
        <property type="entry name" value="PH_2nd_LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="99"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1023" mass="115912" checksum="3EF7CB6AC1B709EF" modified="2013-05-29" version="1">MIWMERLERNRRNSEAWMSGREGLTWYGRGRLSLREPRDALRRGLEGISGGIWQKGVDLDGPPSRKSSVTSDTSQSSGQTTISGATTPEDGVEQRMVDCVILHGEVMSISTHVGLFQNKKHEYLVLTNDELFKFKSRIKAVMAFPSIAPINECNEKISKVHTIHGIFRKQHMEMDQHSLLLRQIIAIREIGPTSFSIYYDDPFLSSSFSTVSIITLHYRSSDIMRCWIIHIRAAVQLQCVSGAFLSSKQFDYVKNYMKYSYENNKVSEQNFKAFRVIQKLSKSSRSDSGQDDMTKRVFVPRILVIGTYSIHILPIPSLEYPAFSTNTFRPFDIPTHGLLSLSSIIVSPNDDYMRLWFQIPCNSTNCLDFASCKSDEIMAIIKKTIDHLRPHWPNTPFSINLPQDFEALSLSKKSENIKANIESFQNTLRGYAISYGVDASNIYYQIYQKDSKSIFRLLPPTHFVSKKYSNKDYSLLELLAVFRSLRYQSFNEISFADINLSCLKAKKYRHDDANFHERAILNLKAGLERGSVLQEELRDLAIFNKSLIKLNLSGTIPKACMSNDSDEKGSEVVAALMPLNRHELITQVRCFNFSKIELDSVDVDWLLDAVTNRFSRLEGLELSKCGLSCRSLSILLQGLEIQHNTMMTLDLSHNPGMIEINALNDTLSKLSYLKILRLGYCTFDLPETFIQPQSLYSLRLHELCLDGIILSETIIFLISLYLSDYASFSLRILSLKSCGITGTNFAKILNAINLVDQPRDERLQILAGDNRLFDGHDEIVSSILMGRGPARISIASLDYSSEEQFQYLLKAITVSKHISHLDISRIGLPYEASKETCKYLAELFEKNTSLRELDLTGEIGLLQTTGFGSGIAQSLKSLEKNKSLEVLKIEGNSIKEKGAEIIADVLLVNTTLRRIDLDKNMIGFKGFSAIVSAMATNTTVIKLSPFIHDYEHHLLHISIDSNAALTSKTAFSSVRKRHSICSKDLNLIRESLKGTSKVLKEQWNREAMKLESYLTRNRLKLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7P5A0</accession>
    <name>M7P5A0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit D</fullName>
            <shortName evidence="5">eIF3d</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02826</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874861.1">
        <property type="nucleotide sequence ID" value="XM_007876670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P5A0"/>
    <dbReference type="STRING" id="1069680.M7P5A0"/>
    <dbReference type="GeneID" id="19896515"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02826"/>
    <dbReference type="eggNOG" id="KOG2479">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024521_2_0_1"/>
    <dbReference type="OMA" id="FMDKRDN"/>
    <dbReference type="OrthoDB" id="16538at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098808">
        <property type="term" value="F:mRNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002191">
        <property type="term" value="P:cap-dependent translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03003">
        <property type="entry name" value="eIF3d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007783">
        <property type="entry name" value="eIF3d"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05091">
        <property type="entry name" value="eIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016281">
        <property type="entry name" value="EIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA gate" evidence="5">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="570" mass="64627" checksum="7263AF9264BC373B" modified="2013-05-29" version="1">MSTFKLPTLRKATDPWGPTDTIETEEDIPYTPFSKSDRLGKTADWTLDPLRDGREQRQRQYGRYKEQYQVYGSGVASIFAYQHSEDESTFSVVDNRTGTKTRLGSRSGALLRGRGRGNLVRGSGRGNYFIRTVSRGYQDANRNVRNGFQISRGLKKFGWKEYDKPQRLRDASVTVKHDWQLLEEIEFSRLAKLSFEVNNGIDLETYGFLRYYDKSYDKISTKAERLLQVIDGVHYNPTTTDDPVIQKLAMNNEAKVFIIDSILSLLMCATRSVYSWDIIVIRESDKLFFDKREGGPFDYVTVNENAADPPMEPSEGQKETINTPGQLSLEATYINQNFSQQALKDPDSEKYLFSNPNPFYNPEEETESLAPRGYKYRKFNLGMFGDEPITLICRTEVDAIVKNPSGEDFFCSIKALNEFDPRAQGAGGALDWRSKLDSQRGAVVATEMKNNSCKLARWAIQSILAGSQLMKLGYVSRANPRDVQRHVILGVAGYKPKEFVSQMNLSLSNAWGIVRTIVDLCLGLSEGKYVLVKDPNKSIIRLYSVPSSTFEESNDPNLEDLLTFENGNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7P5U0</accession>
    <name>M7P5U0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02561</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874574.1">
        <property type="nucleotide sequence ID" value="XM_007876383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P5U0"/>
    <dbReference type="STRING" id="1069680.M7P5U0"/>
    <dbReference type="GeneID" id="19896253"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02561"/>
    <dbReference type="eggNOG" id="KOG0768">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_3_0_1"/>
    <dbReference type="OMA" id="IGPRTMW"/>
    <dbReference type="OrthoDB" id="276989at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000095">
        <property type="term" value="F:S-adenosyl-L-methionine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="2"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="120"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="229"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="36574" checksum="956EFF8477DE3761" modified="2013-05-29" version="1">MKPFLETALASIIAGFMVDIILFPLDTMKTWTQEEKKNMNKNEYKVFKQGMKRNIYSGLGGMIMGSIPSSFVFFTIYETTRSILIEDEYKKIINKTWNIEKDVLLNKNESKMSDLMDRRSMILSCSFAACLSELAACIVRMPSEVIKQRTQAGQYSSSWEAFVDIFPGKKNQRYGGLYCGFVSTIIRDIPFSVLQFPLWEILKQKMSENSNIKILSNISIPFLGETTLSSTLQSAISGSIASSIAAALTTPLDVVKTRTILSQTKPNWINCATRIVKEEGIRALFKGIIFRITWISMGGALFLGTYDGVHGLISNLSNQDFKQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7P5Z7</accession>
    <name>M7P5Z7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02594</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874609.1">
        <property type="nucleotide sequence ID" value="XM_007876418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P5Z7"/>
    <dbReference type="STRING" id="1069680.M7P5Z7"/>
    <dbReference type="GeneID" id="19896286"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02594"/>
    <dbReference type="eggNOG" id="KOG0627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_604277_0_0_1"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="8">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="453" mass="51280" checksum="2A2B69AB265374FD" modified="2013-05-29" version="1">MSVDPLFGGDLVKSPAALGNFIPLPQAKNVPAFLNKLYNMVSDSASDSLIKWSASGDSFLVLRPEHVAKHILPRFFKHHNFSSFVRQLNMYGFHKVPHLQHGVLESDSPNEVLEFSNPNFLRDQPDLLCLVTRKKGPQSGEDGSSLDYSAIISEIQSIKKHQLTISSDLKRIQMDNQALWQEALNSREKCRHLQETIDKILKFLVSMFSPEKRSLVQKKRRLLLEEKSVSSQEENCHSNYSVSNVGNHFSPQELLPNDDVVLSCLIEQGIIQNDENRFTLPYLNTTPLLTPPLICSHENLSIEQPYSNNILEIKTNENLDKNINSQIISQDQALQSLVNLLGMDINQINPELPAEDNVEIVKNVSNGNYTLESKNNSTEYFPNEYDYENVDIDEFLNQYGSEHSFDENNSILSNSSVKKDSNTGISQEINGVNGDININKNFLISGSKRKRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7P609</accession>
    <name>M7P609_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1A58)-methyltransferase subunit TRM6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02605</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRM6/GCD10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874619.1">
        <property type="nucleotide sequence ID" value="XM_007876428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P609"/>
    <dbReference type="STRING" id="1069680.M7P609"/>
    <dbReference type="GeneID" id="19896297"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02605"/>
    <dbReference type="eggNOG" id="KOG1416">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010916_1_1_1"/>
    <dbReference type="OMA" id="TRCRPYQ"/>
    <dbReference type="OrthoDB" id="10254665at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017423">
        <property type="entry name" value="TRM6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945:SF0">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04189">
        <property type="entry name" value="Gcd10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="423" mass="49204" checksum="8C07E54F12424F8B" modified="2013-05-29" version="1">MVVFTNGGDLEVIIDEKNPTKEVILPNSSIFLKLPSNLLKFIIVKQNTIINLGKFGTFCTNDIIGHPYGFTYEICNQELKIMRSDRIHEIEDEIANNKETMDDSFNQLLTYDEIMLLKQNKDLSGQDIVNKIVFSHKTYDQKTEYAKDKYIRKKIQKYQKGFTTMFPTIWEISEHILMKDFLKIMDLRAEIIAYILNLGNVQPGGKYIVVDETSGLLVASILERMDCIGQIMYIHTNEHPNLDNCKYFGQDYIPDRLIEKDVLLTLNWLNVINRNQEIEFENKDINTMKTKYIEKYLRKKKVHERLKRNIQLLNKGEFDGLFIASTYDPSSILPHLIPFVAGSCSIIIYSPYREILVATSHYISSRNTHDILAPIISEIRHRQYQTLSNRTHPFMVSRSFMGYVLSTIKVLPCLKNLRPLGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6F3</accession>
    <name>M7P6F3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_02393</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874398.1">
        <property type="nucleotide sequence ID" value="XM_007876207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P6F3"/>
    <dbReference type="STRING" id="1069680.M7P6F3"/>
    <dbReference type="GeneID" id="19896086"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02393"/>
    <dbReference type="eggNOG" id="KOG0761">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_0_0_1"/>
    <dbReference type="OMA" id="DQTSVGA"/>
    <dbReference type="OrthoDB" id="1747031at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031921">
        <property type="term" value="P:pyridoxal phosphate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045315">
        <property type="entry name" value="Mtm1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760:SF2">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="7"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="142"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="248"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR09450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="38869" checksum="B1F67B435C05ED45" modified="2013-05-29" version="1">MEQISEITIIQKIFSACIGAIVTSVVVTPFDLIKTRLQSQTVDTFIMKSCCRNIFYSSFHSQNVGEIACCFNTDSMLNHFCVDYTTDSSRNRFNGTLEAMIKISRNEGFTALWRGLSPTLVMALPSTIIYFVGYDHLRQYFSSPLAPLFCGAFARTMSATVISPLELFKVRLQSMAHSPSSSSIFSTVVTSIQDMVKVQGFQSLWKGLSPTLWRDVPFSGFYWLGYEKIKYFLNKSPEPFKNLNPKTSEFVKSFISGGLSGAIAALITHPFDSVKTRRQIWHNTNGSISAVRQNTWKVMYDIFKETGIRGLFRGAVPRILKVSPACSIMISSYELGKLFFTGSFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6I7</accession>
    <name>M7P6I7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial ATPase complex subunit ATP10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874063.1">
        <property type="nucleotide sequence ID" value="XM_007875872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P6I7"/>
    <dbReference type="STRING" id="1069680.M7P6I7"/>
    <dbReference type="GeneID" id="19895778"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02084"/>
    <dbReference type="eggNOG" id="KOG4614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047290_0_1_1"/>
    <dbReference type="OMA" id="YFPNFHG"/>
    <dbReference type="OrthoDB" id="17089at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007849">
        <property type="entry name" value="ATP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106:SF1">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05176">
        <property type="entry name" value="ATP-synt_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="8"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="27138" checksum="3A58786D500225C2" modified="2013-05-29" version="1">MANPPSLVKNGEKNLKNWRESLNNLLSLEKNRERREKLLKEASKSYWDDFQGMKYHQGKKWIAPNYLLNKDQALYIANFYGRTLLNVTTDTTPFIESSAASLVSIFSSKSGEEHIKSFLSPKLYLEVPDLKYIYINLQESFIKAILVRLFSKNIRNSISKEYHNTYFFINKLPKDIKENMMITNMYVGYIYLVDNQSQIRWAGCGNATKEEKENLIICSQKLIKEYKKSVEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7P7A1</accession>
    <name>M7P7A1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">General transcription and DNA repair factor IIH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_01925</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the GTF2H2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873901.1">
        <property type="nucleotide sequence ID" value="XM_007875710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P7A1"/>
    <dbReference type="STRING" id="1069680.M7P7A1"/>
    <dbReference type="GeneID" id="19895619"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01925"/>
    <dbReference type="eggNOG" id="KOG2807">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028556_2_0_1"/>
    <dbReference type="OMA" id="INWVEVP"/>
    <dbReference type="OrthoDB" id="284275at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000015">
        <property type="entry name" value="General transcription factor IIH subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007198">
        <property type="entry name" value="Ssl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004595">
        <property type="entry name" value="TFIIH_C1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012170">
        <property type="entry name" value="TFIIH_SSL1/p44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00622">
        <property type="entry name" value="ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07975">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015919">
        <property type="entry name" value="TFIIH_SSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01047">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VWFA" evidence="13">
        <location>
            <begin position="94"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="12">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR015919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR015919-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR09740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="467" mass="53300" checksum="22A4217C77E728D1" modified="2013-05-29" version="1">MICLHQMFLFLRRKEAKKIHKKEKRARKNRRSLLLKSTSAGEYSWEKTYHRSWDVVQEDQQGSLTTTLIQMTQEGKRKRILRDTVPLQRGIIRYLVLVLDLSSAMAKRDMIPTRYLVEIDHASAFVLEYFEQNPLAQLSILGMREGRAVLISYQGGSPHEHLIALKRLKQMDPSGDVSLQNALEMSRTLLYSAPKHGTKEVLLIFGSLMSLDPGDIHETIDALIKDKIRVYMVGLSASVSICQKICKETNAGDESSYGIVLNEQHFKDLLMQFVIPPALQKSYESSGTLVMMGFPSKLVEKETLCSCHSNVIKEGYLCPRCYSNVCSLPINCPNCDLTLIMSTHLARSYHHLFPLKNWVEVPWEEAVSTHCYACLMPFPEKPKELTSDLFYNTINHSKEKNRIDSFSVMHNSVSISFRYACSDCHKHFCIDCDVFAHEILFECIGCQTTLKYKENKGASALALLEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7P7F4</accession>
    <name>M7P7F4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mob1/phocein family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873931.1">
        <property type="nucleotide sequence ID" value="XM_007875740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P7F4"/>
    <dbReference type="STRING" id="1069680.M7P7F4"/>
    <dbReference type="GeneID" id="19895648"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01954"/>
    <dbReference type="eggNOG" id="KOG1852">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_906484_0_0_1"/>
    <dbReference type="OMA" id="QRFTKFV"/>
    <dbReference type="OrthoDB" id="10262609at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="36042" checksum="958EA89D49740B97" modified="2013-05-29" version="1">MSSFAHSKGSVKPLSEDLTCVNTIPLLNEPIKSSVDESLDIKTLVDRPFKKRLRPGMKKEDIPIVPLIELNFEGPFSLEEYLDGLLSNETSHPMSVKRTKEIAEPPKGVDPWIWVYELIRRFIVDLNLLVVGMLEDSCSPEKCPEMRANEWQYLCACHNPPQECVAIDYILHTLDNTSTLLCSDKYFPSKISIPLSSTRHFSSIMRRLYRIFNHAWYKHYEIFWKVENEISLYRRFMAVSEYYHFKYEHSDMVNEAYSKEIEDGYHQDQEKVDNYNPQTLNDHNYKTLNNSYEYDKENRGNKNMLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7P7U3</accession>
    <name>M7P7U3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01694</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873657.1">
        <property type="nucleotide sequence ID" value="XM_007875466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P7U3"/>
    <dbReference type="STRING" id="1069680.M7P7U3"/>
    <dbReference type="GeneID" id="19895388"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01694"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OMA" id="GFTIYIC"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF85">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G00710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="28"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="492" mass="56088" checksum="34CD50D3E266426D" modified="2013-05-29" version="1">MEPDFALDNSKFDEKYDKKLVRRIDLITIPIAVIFYLLSYLNRTNIGNARLSGLEKELRISEKQFKFSLTILFIPYILMDIPSNLIMKKIKPNIWLPSLVVSFGIIGTFQGLIKDVNGLYISRFFLGLASGGVLPGVILYLSGWYKPRERQLRMAMFWSSSIISSTFGGFIAAALETMGGLAGLSGWRWIFIVEGLITVFFGILGYFMMPQGIENTRFLTSDQKYWASKRINLEEHKSSVIISHPDTGEMPYDNKRFKWSYVTSCFTTFHILLLAFIAFSSGLNIYSCAYFMPSIIKSFIGADKSIEIIQLLTIPPYLIPFATILLTSYYADKKSQRIYIIIIFNIIAVIGMAIAYSNISPGFNYFSMFFIVCGIYTIFPPHLALVSNNVAPYYKKATAIGFMIVMTNSGGILSSWMFNKSEAPRYAMSYAIILILTAISVIVAIILRFYYVKENKRKEKLLAEKKESFNTVEEFYKACDQGDRHIVFRYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7P9Q2</accession>
    <name>M7P9Q2_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01304</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873229.1">
        <property type="nucleotide sequence ID" value="XM_007875038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P9Q2"/>
    <dbReference type="STRING" id="1069680.M7P9Q2"/>
    <dbReference type="GeneID" id="19895001"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01304"/>
    <dbReference type="eggNOG" id="ENOG502QPTQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007127_6_2_1"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000016">
        <property type="entry name" value="Magnesium transporter ALR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF55">
        <property type="entry name" value="MAGNESIUM TRANSPORTER ALR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="601"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="632"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="657" mass="74304" checksum="41BEAEC5F794AE73" modified="2013-05-29" version="1">MGTHNSEPFTGISSDAPLDHSDQVECFSDLNFTEDSMRSPGFSNRLSQSSLTLHRSASWHRLSPSHSETSQIFSDNRDNSSRACLIHDVNTGGMYNFDIKDVIPPIPIISSNVRPLPASEACNHHADKRHGDPVISHVSSGDIPVSSVSTTNSKKCKYSSILYTDGQPQEAYEHLSSDDDSASVTSRPSSHIDSADSKSEKVEEDVCFPMTEECRVVKGVVDFEELNKFVTSQCLKDSDVSFTKSRKYSTGSVVKGAFASKNYLSLNLDKCENDVFDENYNDIPYKNSLSSSAAALDPQQKVEFCNKTEGIDISDRFSFFSSNTEKTIHVREIGDILLEGKTFQDIFGPDRGTWWLDCLNPTDVEMKMLQKVFSIHPLTAEDIRVQETREKVELFRSYYFVCFRSFEQDAQSEDYLEPVNIYIVVFREGLLTFHFSPIVHPANVRRRIRQLRDYVDISSDWICYALIDDITDGFGPCIHSIEKETDAIEDAVLITRNHESREMLRAIGCCRRKVLSLFRLLYGKADVIKMFAKRCTENYNVAPKSEIGLYLGDIQDHLITMTQNLIQFEKILSRSHSNYLAQLSISYVQSNERSSAMFSKITVIGTIFLPANIITGLFGMNVAIPGEHKSGWFWGIFWCIIGYIVLVLLIARHFKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7P9X6</accession>
    <name>M7P9X6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase III subunit RPC9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01373</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC9 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873304.1">
        <property type="nucleotide sequence ID" value="XM_007875113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P9X6"/>
    <dbReference type="STRING" id="1069680.M7P9X6"/>
    <dbReference type="GeneID" id="19895070"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01373"/>
    <dbReference type="eggNOG" id="KOG4168">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092529_3_1_1"/>
    <dbReference type="OMA" id="VMIINLR"/>
    <dbReference type="OrthoDB" id="1746530at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038846">
        <property type="entry name" value="RPC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561">
        <property type="entry name" value="CALCITONIN GENE-RELATED PEPTIDE-RECEPTOR COMPONENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="7">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="136" mass="16100" checksum="3E73638A050BDEB6" modified="2013-05-29" version="1">MKVLIKRDAFLTNYEVLRHIYEEELQKKHNIDNTGSKQFINENLSTIQFQLRKYLEELPAKKQSAKQVCNLTKELEIYSLTKAEKLMIINARPDTLVELYALIEECEERFNLEQLQQILDHIHSKMPLDSHEILDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7PA94</accession>
    <name>M7PA94_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">60S ribosomal protein L7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00904</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872815.1">
        <property type="nucleotide sequence ID" value="XM_007874624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PA94"/>
    <dbReference type="STRING" id="1069680.M7PA94"/>
    <dbReference type="GeneID" id="19894602"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00904"/>
    <dbReference type="eggNOG" id="KOG3184">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055156_0_2_1"/>
    <dbReference type="OMA" id="IVEPWIA"/>
    <dbReference type="OrthoDB" id="28644at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_uL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005998">
        <property type="entry name" value="Ribosomal_uL30_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01310">
        <property type="entry name" value="uL30_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="5">
        <location>
            <begin position="12"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="4">
        <location>
            <begin position="88"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="29062" checksum="49C245A85512D3DC" modified="2013-05-29" version="1">MISSEIENQAFIPETLLKKRKAIDKENIEKKIRLAERKKNLRVKRDVIFKRAEKYVQEYLENEREEIRLKRLARKEGNFYVESEPKLFFVIRIKGINKIPPKPKKILQLLRLLQINNGVFIKVTKATANMLRLVEPYVTYGSPNLKSVRELIYKRGYGKINKQRIPLTDNSLIEDSLGKYGIISMEDLIHEIVTCGPNFRQVSNFLWPFKLSNPNGGWRRRKFKHYIEGGDAGNREENINSLIRKMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAN5</accession>
    <name>M7PAN5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01066</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EMC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872977.1">
        <property type="nucleotide sequence ID" value="XM_007874786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PAN5"/>
    <dbReference type="STRING" id="1069680.M7PAN5"/>
    <dbReference type="GeneID" id="19894763"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01066"/>
    <dbReference type="eggNOG" id="KOG3060">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052388_1_2_1"/>
    <dbReference type="OMA" id="MSDQEGW"/>
    <dbReference type="OrthoDB" id="124397at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055217">
        <property type="entry name" value="TPR_EMC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22890">
        <property type="entry name" value="TPR_EMC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="EMC2 TPR-like" evidence="5">
        <location>
            <begin position="81"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="145"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="299" mass="34548" checksum="70CA483A303121D4" modified="2013-05-29" version="1">MHKNIEALRRLRMTNSSCPENVLKLSKPIIQSNNPSLFRDEIWEIYEQTFLASLEIGDDELANQCLTELLKKFTTSTSVIALKGLYLEAIGNTSEALKYYNDILSKDESNIPILKRRITLLRSLGKTEEAINELVKFLDIWYLDAEAWAELADIYFSFHLYKKALFCYSELLLLQPSSHLIHARCALVLYIQSFTKPNLLHAAAKEYLRSIELNENFLQGFCGLKECCISLLKQPSSFWNTNKKINYEISVFKEKPLNIKKVKSLDEIASKMLRKFLHEGKPPINEKNVQKYVKSLIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7PBP7</accession>
    <name>M7PBP7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872187.1">
        <property type="nucleotide sequence ID" value="XM_007873996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PBP7"/>
    <dbReference type="STRING" id="1069680.M7PBP7"/>
    <dbReference type="GeneID" id="19894011"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00313"/>
    <dbReference type="eggNOG" id="ENOG502S0ET">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_973590_0_0_1"/>
    <dbReference type="OMA" id="YRTRFED"/>
    <dbReference type="OrthoDB" id="5346159at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990862">
        <property type="term" value="C:nuclear membrane complex Bqt3-Bqt4"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070197">
        <property type="term" value="P:meiotic attachment of telomere to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044820">
        <property type="term" value="P:mitotic telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037548">
        <property type="entry name" value="Bqt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38044">
        <property type="entry name" value="BOUQUET FORMATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38044:SF1">
        <property type="entry name" value="BOUQUET FORMATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="2">
        <location>
            <begin position="30"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR11285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="286" mass="32286" checksum="CB6F26A225A9E85C" modified="2013-05-29" version="1">MRNLPEKNKFIGKIKKSIIVKQCKVYRTRFEDNTCMDFVLLPVFISEKNNSNFIVLMKHDKDYINATSMFRFAFPSATKAQERLELDNYVKHLHSATSNLYVSGIWVTFDDALLLADDYGIRSWIKALINASENSNDIASPIKNLSPETIRKYIQSSVGPVSNLDSSISSDINSPFSCEIPFQKSRVKSASPEKKILRSPRKGNSEIPLKSTKSTLSPTLSTSNLNIPRISKKRPLELSGPDDFVPIKRSKIEQLEKEVVIERKRVKTLIALAFSLGISATLPYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M7PC38</accession>
    <name>M7PC38_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_03481</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0357 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875571.1">
        <property type="nucleotide sequence ID" value="XM_007877380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PC38"/>
    <dbReference type="GeneID" id="19897168"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03481"/>
    <dbReference type="eggNOG" id="ENOG502S73R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128832_1_1_1"/>
    <dbReference type="OMA" id="NIRDGDS"/>
    <dbReference type="OrthoDB" id="447314at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018559">
        <property type="entry name" value="DUF2015"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023:SF1">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09435">
        <property type="entry name" value="DUF2015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="128" mass="15154" checksum="FCE860802F8C45CC" modified="2013-05-29" version="1">MHLLIAWIFLTFFVFFSCLLIMKRFCKLHMPFKLFKEKKSYFQVDSSFQADLEEGFSSNTFDLYQNIENEDSRAGLDNLGKEEIYHIMNKYKCGFDDARVISNKERMKYNSIDPQTGKPTDPRAVFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7PC53</accession>
    <name>M7PC53_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fumarate hydratase</fullName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. In mitochondrion, catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. In cytoplasm and nucleus, involved in DNA repair in response to DNA damage: following DNA double-strand breaks (DSBs), translocates from the cytosol to the nucleus and promotes DNA repair by catalyzing the dehydration of L-malate to fumarate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872376.1">
        <property type="nucleotide sequence ID" value="XM_007874185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PC53"/>
    <dbReference type="STRING" id="1069680.M7PC53"/>
    <dbReference type="GeneID" id="19894188"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00490"/>
    <dbReference type="eggNOG" id="KOG1317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021594_4_1_1"/>
    <dbReference type="OMA" id="AKWRAQT"/>
    <dbReference type="OrthoDB" id="1738025at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000002">
        <property type="entry name" value="Fumarate hydratase class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00979">
        <property type="entry name" value="fumC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008909">
        <property type="entry name" value="PRK12273.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444:SF1">
        <property type="entry name" value="FUMARATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="5">
        <location>
            <begin position="50"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarase C C-terminal" evidence="6">
        <location>
            <begin position="447"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="502" mass="54842" checksum="A5582C91FA16F9FB" modified="2013-05-29" version="1">MTYQSLKFFIKLPSQFSLCKKLNIKYKNSRQFSLSKQTYEKFRIEKDAFGELQVPINCYWGAQTQRSLQNFNIGGPTEKLPLPLIKAFGILKKAAAIVNIDYGLDEKIGKAIQQAADEVISGKLLDHFPLVIWQTGSGTQSNMNANEVISNRAIEILGGKLGSKDPVHPNDHVNMSQSSNDTFPTVMHIAAVTEITQNLIPSLQYLHDALLEKEKSFVGIIKIGRTHLQDATPLTLAQEFSGYVTQVKYGIERINNTLIGLRKLAQGGTAVGTGLNTKIGFDIKIAEQISKLVGEKFETAENKFEALAAHDAIVETSGSLNTVACSLMKIANDIRYLSSGPRCGLGELSLPENEPGSSIMPGKVNPTQNEALTMVCAQVMGNHTAISIGGASGQFELNVFKPMLIANLLQSTRLLSDASRSFAKNCVIGIKANESRISELMNKSLMLVTALNPHIGYDKAALIAKTAHKEGKTLKETALKLGLLTEQQFEKWVDPHKMIGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCB8</accession>
    <name>M7PCB8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Plectin/eS10 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00558</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 33 different proteins. The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and at least 46 different proteins. eS10 interacts with GCN1 (via middle region); this interaction is direct and promotes GCN2 kinase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872451.1">
        <property type="nucleotide sequence ID" value="XM_007874260.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCB8"/>
    <dbReference type="STRING" id="1069680.M7PCB8"/>
    <dbReference type="GeneID" id="19894256"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00558"/>
    <dbReference type="eggNOG" id="KOG3344">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089349_0_1_1"/>
    <dbReference type="OMA" id="YRRRDQE"/>
    <dbReference type="OrthoDB" id="5211809at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000025">
        <property type="entry name" value="40S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005326">
        <property type="entry name" value="Plectin_eS10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037447">
        <property type="entry name" value="Ribosomal_eS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03501">
        <property type="entry name" value="S10_plectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Plectin/eS10 N-terminal" evidence="8">
        <location>
            <begin position="3"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="89"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00063610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="154" mass="17931" checksum="53A542777934E107" modified="2013-05-29" version="1">MLIPKNSRKKIYEILFRDGTLVAKKDFNASSSIELPDIPNLHVIKACQSLTSKGFLKTRFSWQYYYYTLTNEGIDYLKEWLHLPNEIVPNTHKRQTRPQVSRVSRGGDNTYRSSKSDKYEYRRRDHGEKKEGITPGDFAPSFRGGIERMQPVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCE7</accession>
    <name>M7PCE7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Metaxin glutathione S-transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871875.1">
        <property type="nucleotide sequence ID" value="XM_007873684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCE7"/>
    <dbReference type="STRING" id="1069680.M7PCE7"/>
    <dbReference type="GeneID" id="19893722"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00024"/>
    <dbReference type="eggNOG" id="KOG3028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055680_0_0_1"/>
    <dbReference type="OMA" id="RNAWLYT"/>
    <dbReference type="OrthoDB" id="198787at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF44">
        <property type="entry name" value="OUTER MEMBRANE PROTEIN (SAM35), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17172">
        <property type="entry name" value="GST_N_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="2">
        <location>
            <begin position="59"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="1">
        <location>
            <begin position="205"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR11580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="31939" checksum="CC28EDFD414DFEAE" modified="2013-05-29" version="1">MLSIKPLITPTLISKLFDRFPLLHYDSIQVQSPLDTSCNLLFIQSEEALEQKPSYDLESLRWQTYFIFSKIPHVLVPSTPYASSSNKLPFFIPSNSSIPFALSSTEFQNWLLLQGVKDFSEKEPLLSADTDSYVSLVENTLYDAWYYGFFIEPENFKQVTSLLYIKDAWPICIFTKWQFQNQIRKKLSVRQKTGLLNAKEIYADASHALHALSVKLGQDKWFFGAEDPSYIDATLFAYTHLVLSINLPDDTLAHEIKKHENLVKHAERVLNICFPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCV9</accession>
    <name>M7PCV9_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872030.1">
        <property type="nucleotide sequence ID" value="XM_007873839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCV9"/>
    <dbReference type="STRING" id="1069680.M7PCV9"/>
    <dbReference type="GeneID" id="19893867"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00169"/>
    <dbReference type="HOGENOM" id="CLU_2607004_0_0_1"/>
    <dbReference type="OrthoDB" id="16510at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="79" mass="9678" checksum="B790AD80BD5D6655" modified="2013-05-29" version="1">MDEKYYQIHPIVSDAIVHNFKIISHIRSVTSIFFWSCCRYFKFNIILWTFVLYFWNILCKPFNFFYINKTASIFLFSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7PDW1</accession>
    <name>M7PDW1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">GPI transamidase component GAB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_03128</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875186.1">
        <property type="nucleotide sequence ID" value="XM_007876995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PDW1"/>
    <dbReference type="STRING" id="1069680.M7PDW1"/>
    <dbReference type="GeneID" id="19896815"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03128"/>
    <dbReference type="eggNOG" id="KOG2552">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030193_0_0_1"/>
    <dbReference type="OMA" id="ALWHLWI"/>
    <dbReference type="OrthoDB" id="549017at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009600">
        <property type="entry name" value="PIG-U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS U PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06728">
        <property type="entry name" value="PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="48614" checksum="6F259234613C9D2B" modified="2013-05-29" version="1">MYSFELRKESYSKYIVTLIFSLGFFIRIILLKNKNLVSLLSNRVEIATAVTSYKRLKEGLFLYEHGISPYSGGLFHQAPLLLVLFSIVKLISNSEMLVLLLYALIDIFSAWSLLDLSDSMFSKDSSLNHWKKYISVSLFLFNPYSIISCVGMSTAIFTNCFILTSLSYVQRRKSIQSIFFLALATYLSFYPIVLFPPLILILQKNDIKKKDSISRNIILFLIELLLLLLLSFITTNSWDFLSATYGAILSVSDLTPNIGLWWYFFTEIFDSFRLFFVFVFQLHIFIYIIPLCIRLRKYPFFIIIILCGLMSILKSYPSIADVVLFMSLFPFLHSIYSYMRHIFVTTICFLYCTFLGPAFYYLWTYIGSGNANFFYSITLVWNFNLSIIITDIVFAILKMEMEIERPDMKGIDVIQANY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7PEC5</accession>
    <name>M7PEC5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Centrosomin N-terminal motif 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_02973</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875019.1">
        <property type="nucleotide sequence ID" value="XM_007876828.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7PEC5"/>
    <dbReference type="GeneID" id="19896660"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02973"/>
    <dbReference type="eggNOG" id="ENOG502R0AV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_278102_0_0_1"/>
    <dbReference type="OMA" id="QETHAND"/>
    <dbReference type="OrthoDB" id="10255000at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019528">
        <property type="entry name" value="PACT_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10495">
        <property type="entry name" value="PACT_coil_coil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="8">
        <location>
            <begin position="145"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Pericentrin/AKAP-450 centrosomal targeting" evidence="9">
        <location>
            <begin position="1238"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="196"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="641"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="794"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="993"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1332" mass="158232" checksum="BD6A6CAC9D7F62BC" modified="2013-05-29" version="1">MHPLLSIQTPRTDVGTVNSIDADELSFGSREPSFISPTKKENWKSFKALSTPAPERILSDRTKNLINVRHEFTPLLQSAAKKEPFSYVDLKKKPKSEGSIENEKSVNTSRENNPEESSSSIVSVKSIIELPEQDLLKEKNGTTLTLREQERIIDTMRKENWGLKLKIHFLNDRLDKLAPDQIEKALKENIENKIQQAKLIQEIKKYRKSLLESEKKIQEISVNGPKGENLESNEIISDQKKILDKIALENNQYANELFKAQEKIETLSKEIEKLKNGENDITIYEKLNYLEEQLQRALEKNEDMVAELQEKQNKIDEKEDEIELQEEERGKLKQVIEELEQKYLSRENNREVNDYSTHIDSLKNDLNIAKKKIDEKEKTIQKLILEKDNSNELSDELKKARSELDKISNEYYEFKNIHEEKIYNLENSYNNLNNELKIKKGEIASLHKQLETKESNTLEINKNMQDILNEKYKLENDLKEAYNNIKELHISLEEYDNRQEQLEHDLKEKEDELSEAIFNLRSLQQELDSSTLEYEKEKKDLHSKIAKLKQNWDEERIQLTNETELIRDSLKQYQERSERTLFDLQEEKNILQNNLKEIKQQNSNLQENINKLVVTENTVLKNNEKFQETLQSQEERHHKREVQLENQINDQNIRYENQKKELNKALDDMQILKEDLKQVQKSEESLKNDIKLLKIEYNELQQQYTEKQEIIKNKEIQTAQFHEEYEKLKTDYASIKATLKNLYDEKNDLLLLIEKSKSDHIEGADTLSLNKTIKILEHQIESIKFERDKLLKSINFLNESIFNYKNTVSDLEKERDFLKEKLDTFNIHEKIFPQSDEKYFEFQKNINILETQIKLLETEKKKLLETNADLENNFNDALKKINNEEIDLIHEYKIKKMELEEIVHMKEQEQKSLEKQIEQLEITLLNKEKIHKTKIKQLNDEIFLLQDKLEDLRLQQKESIELGNSDEQIISDLPKSILKLKNGLYNTELKTINQHKNYEINNYEIELSELRLKYKNANEIISSMKHEALTREEEFQNRINEIMLKEKSKLTRLQNEKAQLESNLLRMNEEKAILEDEKGQLQRQLSLLETNAIFTSENYINKNENAKIIQEKEELKECLMLTKAELNEIKGNMRTRETQLKEQLYKIGKDKHFLVNKMELAEKKIQTITQERDEISEKVHYLERQLHEDKYLYNNQNYLKKNIRFNEPESKELYTLKLKHKAELKGLSKQIRYLKALVSREEQFRASLSYTKKFFLMKIDSYESCNQANLRLIEKMGIYPDRSLRQNHVTLKIIALMIIAINRMKKFSIEWSKQAKIKEKLFQSLSLIRANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7PEX2</accession>
    <name>M7PEX2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBM21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874820.1">
        <property type="nucleotide sequence ID" value="XM_007876629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PEX2"/>
    <dbReference type="STRING" id="1069680.M7PEX2"/>
    <dbReference type="GeneID" id="19896478"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02789"/>
    <dbReference type="eggNOG" id="KOG3986">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_402849_0_0_1"/>
    <dbReference type="OMA" id="WQTISEV"/>
    <dbReference type="OrthoDB" id="1881at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF36">
        <property type="entry name" value="GLYCOGEN-BINDING SUBUNIT 76A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM21" evidence="2">
        <location>
            <begin position="281"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="698" mass="80474" checksum="414782D6675B07DC" modified="2013-05-29" version="1">MPYMPPSCSSLNKISASVLKCTMDQKIEKEYHEKNTILWDKEWEELPEIWFSTSSKQMKEDMFDSEKKDIKKKEQEKRETRNNMIESIPEYLSNSLRMDNSYKYTREWEEWNNKEWQPWEVNEEKQELQKLSNYLRKVSSSPSFESTLSAYGNTTKELNLSTNLNLTESTDALEDSNRLKVVRKKSGELVKSSLKSEKHKRPQSMPSTPILHKNVQFATKLEEIKHFSQAEKPEEVSKSGLVDESYQDIYGMAFDYDLYDLKKEEKNSDLTIELVNFENSGALCLSQNVQLETVYLSSDKRHLLGRVAVKNISFEKIVGIRFTMDFWQTISEVNAEYTDDILTKQYKDNLDRFVFNIKLHELMNIEDKTLYLCVRYRIPGEEFWDNNSGMNYKIGFKRKFKTHTRPFTHFPAFSLGSRYLDDDFNTESDSHLSMFQSYKNDPFHVSLMNDSTNTKQSLRKKDNFANIFSNRYDFSTSLTAAIKASGTTNYNESKNNDSKTKDINSYEDSIENVDLYFSDLFLVEKPLTRSQSNISFGNDISNTLSLNDTKLSTSFQENKNACDLFKGSSKPSVDSVLYQNFLDSYCFFRGSDKINTQDAESITYTGENPEKNIPSISHKKSNSSSSLSSINEFIPFSSFSGPLFYSQSSLSSISSVDSVSNVQQPSESKTSIDLYYNHLINSSLTLETPGGALTAIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7PEZ9</accession>
    <name>M7PEZ9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_02811</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874845.1">
        <property type="nucleotide sequence ID" value="XM_007876654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PEZ9"/>
    <dbReference type="STRING" id="1069680.M7PEZ9"/>
    <dbReference type="GeneID" id="19896500"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02811"/>
    <dbReference type="eggNOG" id="KOG1733">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141397_0_2_1"/>
    <dbReference type="OMA" id="MAAWNQV"/>
    <dbReference type="OrthoDB" id="7813104at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042719">
        <property type="term" value="C:mitochondrial intermembrane space chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140318">
        <property type="term" value="F:protein transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000001">
        <property type="entry name" value="mitochondrial import inner membrane translocase subunit TIM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="13">
        <location>
            <begin position="10"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR09039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="88" mass="10027" checksum="657340B01C34639C" modified="2013-05-29" version="1">MEDKKQALMQVIRQELAVANATELIGKLNETCYDRCIPKPGSRFESSEQTCISKCIGRYMDAWNIVSRAYISRIQKEKQAQSLGLNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7PGQ5</accession>
    <name>M7PGQ5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein YTM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">YTM1</name>
        <name evidence="9" type="ORF">PNEG_02222</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR12/YTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874206.1">
        <property type="nucleotide sequence ID" value="XM_007876015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PGQ5"/>
    <dbReference type="STRING" id="1069680.M7PGQ5"/>
    <dbReference type="GeneID" id="19895915"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02222"/>
    <dbReference type="eggNOG" id="KOG0313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_0_1"/>
    <dbReference type="OMA" id="DIQAPDW"/>
    <dbReference type="OrthoDB" id="10251381at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110136">
        <property type="term" value="P:protein-RNA complex remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03029">
        <property type="entry name" value="WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028599">
        <property type="entry name" value="WDR12/Ytm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="8">
        <location>
            <begin position="7"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="136"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="184"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="338"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="421" mass="47575" checksum="E2E3C50B23E483DF" modified="2013-05-29" version="1">MENQTKIRVIFITKEKEIEVENTPIFVPLSLNPYGLNEVINHLLEKDPPINFAFLVDGEFLQESLGEYLARKQQTCETTLSIEYIRSILAPKYVSSFLHSDWVSCVKSVDSKKILSGCYDGISRLWNEDGEIITETLSHDGPVKSVCWVENERFATSSMDQTIKIWRLKKKKNTIITCHCVFEMKGHAMSVESIAVNLQTNRLLSSGADGNIGIWDIEENDWVIDEEKSIKKRKRNELSDKIITKKPIYMIQGHSSSCSEIIFDSKDCTVGYSVGTDHSIKTWDLITFSNVDNRVTQHALFSICCIPSMSLLACGSSSQHILLHDPRISLKSTPVQTLKGHTNFVVSLSSCDRNNYVLISGSYDSLVKIWDIRVPNGSLYSIKRQSGKKNTKVFSIDWSNIFGIISGGEDRCLQIDQINDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7PGY6</accession>
    <name>M7PGY6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01905</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873880.1">
        <property type="nucleotide sequence ID" value="XM_007875689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PGY6"/>
    <dbReference type="STRING" id="1069680.M7PGY6"/>
    <dbReference type="GeneID" id="19895599"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01905"/>
    <dbReference type="eggNOG" id="KOG3421">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082438_3_1_1"/>
    <dbReference type="OMA" id="ANWRFVE"/>
    <dbReference type="OrthoDB" id="1875589at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23702">
        <property type="entry name" value="eL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_eL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002784">
        <property type="entry name" value="Ribosomal_eL14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01929">
        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL14" evidence="4">
        <location>
            <begin position="50"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="135" mass="15683" checksum="51C84FF71ABB4B6D" modified="2013-05-29" version="1">MLGRPLFRRMIEIGRVVLFIEGEYKGNLAVIVEVLNCRRVIVDGPKTNVPRHVASLNDIIFTSIVVHYLSPGVRTGIVAKQWDSQDITAKWNVTRLSKKLAARRRRSELNDFERFQVMLLKKQRRREITRVLVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJI1</accession>
    <name>M7PJI1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1772 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873248.1">
        <property type="nucleotide sequence ID" value="XM_007875057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJI1"/>
    <dbReference type="GeneID" id="19895019"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01322"/>
    <dbReference type="HOGENOM" id="CLU_1627778_0_0_1"/>
    <dbReference type="OrthoDB" id="5336366at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="18416" checksum="01885A4EBD7DF101" modified="2013-05-29" version="1">MNKKLGILAISFKIIGTVSIGYVAGSYLCFSKFILPVMKEHYPLSSIQLMLEVTAKHWIRYILPLESLAATLMLSSYILSEPHVSHPYLLYSGFGVASLIPISFFYIQPKITKIIQDIRAKDTLTIPERNLKCWRRSYLANTVLSSIIFFMTVIGSYGDTLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7PKW9</accession>
    <name>M7PKW9_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00716</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872616.1">
        <property type="nucleotide sequence ID" value="XM_007874425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PKW9"/>
    <dbReference type="STRING" id="1069680.M7PKW9"/>
    <dbReference type="GeneID" id="19894414"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00716"/>
    <dbReference type="eggNOG" id="KOG2034">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003488_0_0_1"/>
    <dbReference type="OMA" id="KFFVFPC"/>
    <dbReference type="OrthoDB" id="1845386at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16462">
        <property type="entry name" value="RING-H2_Pep3p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007810">
        <property type="entry name" value="Pep3/Vps18_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058919">
        <property type="entry name" value="Pep3/Vps18_RING_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF26">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05131">
        <property type="entry name" value="Pep3_Vps18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26148">
        <property type="entry name" value="VPS18_RING_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pep3/Vps18 beta-propeller" evidence="7">
        <location>
            <begin position="8"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Pep3/Vps18 RING C-terminal" evidence="8">
        <location>
            <begin position="820"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="779"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF26148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="929" mass="109097" checksum="6AC557F9E59BEAAC" modified="2013-05-29" version="1">MDHRDPSPTFSLEKVVFPYDLTVSVMEVKHNILVMGLCGGRLLRMDLEHPEEIQDLEMPHKYVDVVIERLFLSPNGKHLIVGIRGDEYIYFHGDSTRGKLLTQLKGLGIKCIAWNSQATDTSTKDILLGSYNGNVYETNIQVLNKQNKYVKSVYQVSEKSEIIGLHMDESSNNVDYHYIVVITDRKIEYFMGKKGKNISGDTPVTLDIFLSNVKGSQVFETKNSQYSISPILFHEYCNNMSDRYIGWISECNLFYGSLKMFDINVSEKFSFTLTHLLMDTIKKDFTLPFFFCFTHYHIIVVKQSEIYLLSRLNHQIVFSEKIPLALGEKILGLVTDTYKSSYWVYSKDSVYEIVVSNEDCNIWNLFLKNNDYIKALKFAKKNSHYDIIYRKYGMDLIKQNKVHDAAKILAKTTFPIEEIALKFISMKDYDALRIYLLEKLSMMKKGAIIQKTILSTWLLFLYITKMNLLEDIQRQKNFFNLPDTTQTENKEIQNEFREFIDKYKYDLNREASYYLINSHGRQNELLTYAESINDYAYILKYWIRNQNYDSALDVLNKQDSPELIYKYASILILQRPKATVDIWMLHSDIDPLKLIPAIIDYNQQYKPLIEHNQTIRYLFFVIDQTSITDSIIHNTLLSLLASSENEDEATLLQYLEWQKSKHYYSQDFALRTCIQYKRILSSVYLYFEMNFFEEAIDLALEYDNIDLATTLADKIEDNHILKKKLWIKIAKKVIIQYDGDAKRLQFLMKNNRLSIEDLIPLYPDSIKIDDFKEDICSVLKDYSSNIDFLLKKMEELTQSADNIRNSIEDHNNWFVILNAEEECNICRNMLLNEQFYVFPCQHCFHKDCLFLKVSEDTTSWQYRRIQDLQSLISKFKNDISGKQVQQCKKLTKELDDIISSECILCGSTMIRSIDKSFIDNNMETSFWNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M7PL65</accession>
    <name>M7PL65_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">JmjC domain-containing histone demethylation protein 1</fullName>
            <ecNumber evidence="5">1.14.11.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">[Histone-H3]-lysine-36 demethylase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PNEG_00799</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(36)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:42032"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:9787"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="1.14.11.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the JHDM1 histone demethylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.27" evidence="5"/>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872705.1">
        <property type="nucleotide sequence ID" value="XM_007874514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PL65"/>
    <dbReference type="STRING" id="1069680.M7PL65"/>
    <dbReference type="GeneID" id="19894497"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00799"/>
    <dbReference type="eggNOG" id="KOG1633">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_400683_0_0_1"/>
    <dbReference type="OrthoDB" id="5876800at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140680">
        <property type="term" value="F:histone H3K36me/H3K36me2 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15517">
        <property type="entry name" value="PHD_TCF19_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041070">
        <property type="entry name" value="JHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050690">
        <property type="entry name" value="JHDM1_Histone_Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23123">
        <property type="entry name" value="PHD/F-BOX CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17811">
        <property type="entry name" value="JHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjC" evidence="19">
        <location>
            <begin position="210"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMR11209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="687" mass="79694" checksum="43980022B07B66F0" modified="2013-05-29" version="1">MKVSGRLGISKKWDHCELCTAETAPKDNEITWIQCTPCSRWYHVKCIGELYCIDAIKDYHCRFCEPVYGISTYHPQRRRSSRPRSFVDYISLDQGDVAMSDQHAYTVMIENKTFSKDTFKRIRGSELTKEWAENEGFNEPVLIPTGWDYDGLEMQIPKDLTVQKVLQILGPHEKIEVIDVPLQKEISGWSLGKWVEYYEKPPEKRERIRNVISLEISFSKLSEYIVRPKFVRDLDFADRMWPKDLKEKGVFPKVQLYCLMSVKNSFTDFHIDFGGTSVFYHIIKGSKTFLFIAPTQINLKKYENWCLSSDQSKIFLGDQVKDCIKVDLKEGDTMLIPSGWIHAVHTPSDSLVLGGNFLTHLHIEMQLSIADLERRTKVPQKFKYPFFEKLLWFSTLHYLSIPLEHTENFDHYLHHKKISNIDEQSKNRKIHEKELAGCEMLAKYLFIHAQMAKGLAPITANGEKLNMPTQRQLRAIKLELPFQFFSGDFVELAKAFGRWTYYRKKLSYAEFPKWCLPGPLASFDLISNNIPKQKKNSKIASKKKKNTVCQFDTTLNIQANNKRKNDSNYEGILKQNPSKILNHNLSLHSSRPIYFVKFEDNKKTIKIEDNKKAIKIEDTQISNLISPEFKVDEQKNISQSKLASYNIFSDNTVDNATKQAIKAAMFGLRHNETGQTIPEITSINNFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7PLK2</accession>
    <name>M7PLK2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="4">eIF3l</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00353</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872226.1">
        <property type="nucleotide sequence ID" value="XM_007874035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PLK2"/>
    <dbReference type="STRING" id="1069680.M7PLK2"/>
    <dbReference type="GeneID" id="19894051"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00353"/>
    <dbReference type="eggNOG" id="KOG3677">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029210_2_0_1"/>
    <dbReference type="OMA" id="AGWFIRN"/>
    <dbReference type="OrthoDB" id="15082at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="239"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="476" mass="55996" checksum="7FE87BF5F94049F1" modified="2013-05-29" version="1">MLQNNVYELHGCYENLFTKLTDKYYKNTSWPDAETISPLVNDDANFIILYRELYFRHIYAKLQPTIEQRFQSYDNYCDLFNLILNSENPVNLELPNHWAWDIVDEFIYQFQTFCNYKNRLSKRSEDEIHELRENPQIWSTYSVLNVLYSLIQKSKINEQFIEIKNGRNPNEVAGEFGSQNLYRMLGYFSIIGLLRVHCLLGDFTLALKTMDNIELNKKSFFGWGGNLTLTFTAYYYVGFSYMMLHRYIDAIKAFSHVLFISRTKLYQNRSIQYDHISKKSDQMYALLAICIALCPVRIDDNLFILLKEKYGEQLLKMQRGGPESIPVFSELFSFSSPKFISPLSPDFDNSSGTIIEHQQHHLKIFISSIENQMMLPALKSYLKLYTTMHLDKITSYLEISPENLRTLLLVYKQKTKQVRWSQGSLLNGEIINTSDIEFTLQGHIIHITEVKTTRQYADYFIKTIKQLKRLSLNLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7PLR1</accession>
    <name>M7PLR1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U6 snRNA phosphodiesterase</fullName>
            <ecNumber evidence="5">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">USB1</name>
        <name evidence="6" type="ORF">PNEG_00418</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 2H phosphoesterase superfamily. USB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="5"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872295.1">
        <property type="nucleotide sequence ID" value="XM_007874104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PLR1"/>
    <dbReference type="STRING" id="1069680.M7PLR1"/>
    <dbReference type="GeneID" id="19894116"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00418"/>
    <dbReference type="eggNOG" id="KOG3102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050234_1_0_1"/>
    <dbReference type="OMA" id="KTVVLQY"/>
    <dbReference type="OrthoDB" id="49151at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990838">
        <property type="term" value="F:poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034477">
        <property type="term" value="P:U6 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03040">
        <property type="entry name" value="USB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027521">
        <property type="entry name" value="Usb1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522:SF3">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09749">
        <property type="entry name" value="HVSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR11394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="254" mass="29497" checksum="B8503469F896204F" modified="2013-05-29" version="1">MKNHENTELVTYYSEDEEKCEHPREKVPPLPDFFLDLYKVKPKQGNEPEFHEGRTRTYPHVTGGWPSHIYIDLMPNEKLQILLKKIQESFRIEGIEFKSLVENDLGMPLPLHISLSRSLMLGSDIINEFKNTIKTKVIFESFNIKFSNIAIFKNEDTSRTFLVLIIETGKEILRTILQTVDSIVKKYGCQTFYEENKNSKFHVSIAWCLSHTIIHKTIINRLNNEYSGLLSIHKLHVNQVKIKIGNTIHSVSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M7PLR3</accession>
    <name>M7PLR3_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872300.1">
        <property type="nucleotide sequence ID" value="XM_007874109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PLR3"/>
    <dbReference type="GeneID" id="19894120"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00422"/>
    <dbReference type="HOGENOM" id="CLU_2672110_0_0_1"/>
    <dbReference type="OrthoDB" id="5301067at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="75" mass="8830" checksum="CFA18D097F6BE988" modified="2013-05-29" version="1">MNQQLNISDKEFDSLTLYEKQILLELQYILKTCEQIKENLKKAISITNKEGELHHKQILAIESMKVWEKIRGNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7PM04</accession>
    <name>M7PM04_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00512</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. PCH2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872400.1">
        <property type="nucleotide sequence ID" value="XM_007874209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PM04"/>
    <dbReference type="STRING" id="1069680.M7PM04"/>
    <dbReference type="GeneID" id="19894210"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00512"/>
    <dbReference type="eggNOG" id="KOG0744">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028208_0_1_1"/>
    <dbReference type="OMA" id="WEGLWES"/>
    <dbReference type="OrthoDB" id="5925at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19508">
        <property type="entry name" value="RecA-like_Pch2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001494">
        <property type="entry name" value="Pachytene checkpoint component Pch2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044539">
        <property type="entry name" value="Pch2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058249">
        <property type="entry name" value="Pch2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991:SF1">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23242">
        <property type="entry name" value="AAA_lid_TRIP13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23563">
        <property type="entry name" value="TRIP13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="174"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="430" mass="48932" checksum="A8C0E89BEF9BB01F" modified="2013-05-29" version="1">MEKSEINKDEEEFKKPIIHKPLLHIECSLKEKSTCRFDMASHYVRRFLLENFSSLTLNTEFRNFEDEPLLMKHIEQIRVVEVSGSNKEILYLDEVDLDVHIYQLNNSLPFTNNFDDQDLEDGPMAIVTELPSLSLEGLWDNLIFEDNIKNNLLHFIHTVMLFSDKDVNFNIVTWNRLILLHGPPGTGKTSLCRALAQKLSIRLSNKFSRGRIVEVNSHSLFSKWFSESGKLVGKMFQQIHEMVEDEDSFVCVLIDEVESLTAARKAAASGLEPSDGLRVVNSLLTQLDKLKPHKNVFILTTSNLLEAMDPAFVDRIDIKQYVGDPNPDAIFAILQSCINELGRKGLIGDGIPVPSFTEASISLYSQPNSYSSRLYRIAVDCKGLSGRTLRRLPVLAHAKYLQRPCCTMDEMLCSLEKVVKEELEFSMKIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZAW4</accession>
    <name>A0A0W4ZAW4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major surface glycoprotein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_04013</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000019">
        <property type="protein sequence ID" value="KTW25441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613319.1">
        <property type="nucleotide sequence ID" value="XM_019757772.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.A0A0W4ZAW4"/>
    <dbReference type="GeneID" id="30671549"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04013"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021041">
        <property type="entry name" value="Maj_surf_glycoprot_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003330">
        <property type="entry name" value="MSG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02349">
        <property type="entry name" value="MSG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12373">
        <property type="entry name" value="Msg2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Major surface glycoprotein 2 C-terminal" evidence="3">
        <location>
            <begin position="938"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="772"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1103"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="772"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="813"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="883"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="893"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1111"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KTW25441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1154" mass="127570" checksum="7098DF56824D6A85" modified="2016-03-16" version="1" fragment="single">EVAQKEAAMAQPVKRQAAGQAAGNDEIKEEQVLGLIVKSGYNDDNKCKGDLKQYCEELKKIDKKLENVDDKVKGLCENKDKKCGDLKDKVSKELTDFKTEVEKALNNLTDEKCRKYEEKCLLLEEADPSNLEEKCVKLRDRCYGRRRQGVTKEILFRALEGKVNDTNECKEKMKGICQGLSEYSDELMFSCFNSNKTCEYLKKNHGDNCKPLQKELEDKELVEKCQEYLEKCYFYGSSCSNSKCKESKEKCGKKGIVYEGPKLDFSPVREKPRFPEKIEVENLYKKEEAKGIIVGKPKYKTLRDLALLLIKGRNGKNEGEKCKEALKDCESFKHLDYGLGELCGDKDKEDRCKELVEVEDRCTNFKLELYLKGLSTEFEKDKESDYFSWGQVSKLVSREDCIKFESECFHLEGVCTNKIGKACENVRVACYKKGQDRVLNRYFQEGLKGLIGDLELVTENLEKCQKSVVGNYTKLKEDRRYFTKCHLPTKLCYELLDDVILQSEELEVVLNLRRDFPRKEDCVELKKKCKDLESDSYLNHEKCDTLNRRCEYLKVTEELRKRLLKRGDDALRTQGNCTAVLKKECEELSXRGKDEFSVSCALREETCSFMVEQTENECLFLKNNMENGKIIDKIEKGKGNETLVEELCTLFDPYCHQYIENCPDRLKKANSAGGKGVCLELEEKCKPFFEKLKLENELTHELKGSLGKDDECKKALGKHCSEQKDPANQKFNSFCNTDKDKGVEEKVCKKLVEKVKRKCPTLEDKLDKEKDELKKKKDEYEKVKQESEKFTKEAKLVLSKPEQDGQDGNAPKPGGPPVQPPVPGGTPGGVPVPAPTLAPPAPVPGGTPGSVPVPAPTLAPGAPGAPGAPGAPGTPGAPGAPGTPGAPAGPAAPSTPPAPAGPAGPAGPAGPSGGTPGAPAGPPAPGGSTPSGTTNTSNVILVRRTFVSGEVSEPEKKAFVATARALELYLELKEKCKGLQGDCGFRKDCPGCEAACKEIDKLCEGIEGLKVTPHHTVISTATQTTTTTATTTTTTTTTTTTTTTTTTTATTTESVDGGKVTEECTLVQTTDTWVTSTSLHTSTLTSTSTVTSTVTLTSMRKCKPTRCTSDSSKETETQKEEEKEEEVKPNEGMKIRVPEMIKIMLLGVIVMGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWT8</accession>
    <name>A0A0W4ZWT8_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_04341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="KTW32840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613322.1">
        <property type="nucleotide sequence ID" value="XM_019757852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWT8"/>
    <dbReference type="GeneID" id="30671611"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04341"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KTW32840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="85" mass="9944" checksum="82D9DE7D1D64FD30" modified="2016-03-16" version="1">MILKKLLLSYQKLKEIILAIIKTCKDILTKIIIKISFHSLKQKITTYIYYKKIDVVFVSKNTTLGAIAPLQRRNKNIGIFFKKMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWW0</accession>
    <name>A0A0W4ZWW0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Obg-like ATPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_04322</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="KTW32861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613340.1">
        <property type="nucleotide sequence ID" value="XM_019757835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWW0"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZWW0"/>
    <dbReference type="GeneID" id="30671598"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04322"/>
    <dbReference type="OMA" id="VLRCFDN"/>
    <dbReference type="OrthoDB" id="424823at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="22"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="307"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="31"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KTW32861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="393" mass="44052" checksum="D257E14CF0F9D53B" modified="2016-03-16" version="1">MPPKKQASEENKIFLGHPGNNLKSGIVGLANVGKSTLFQVITKSNLGNPANFPYATIDPEEARVAVPDENFDWLCNLYNPLSKIPAFLTIFDIAGLTKGASTGEGLGNAFLSHIRAVDAIFHLVRAFDDTEIIHIEGDVDPCRDLQIVHDELLIKDTEFVNKHLEGLKRITSRGGQSLELKANKEKQAVVEKVLYQLETEKKEVRKCTWTNKEIEIINSLFLLTAKPVIYLVNLSEKDYLRQKNKWLPKIVTWVNNNSPGDIIIPISVIFEKRLSQMTDSEALEECKRLGTKSILPKIVTTGYSSLNLMHYFTCGSDEVRAWTIRKETKAPAAAGVIHSDFEKNFVVGEIMKFNDLKELGSEAAVKAAGKYMIKGKDYIVEENDIIYWKAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWX1</accession>
    <name>A0A0W4ZWX1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_04321</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBCE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="KTW32860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874247.2">
        <property type="nucleotide sequence ID" value="XM_007876056.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWX1"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZWX1"/>
    <dbReference type="GeneID" id="19895951"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04321"/>
    <dbReference type="eggNOG" id="KOG1491">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3207">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SEESHMF"/>
    <dbReference type="OrthoDB" id="5273213at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.190:FF:000016">
        <property type="entry name" value="Tubulin-folding cofactor E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 410-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849">
        <property type="entry name" value="LEUCINE RICH REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CAP-Gly" evidence="8">
        <location>
            <begin position="22"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KTW32860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="517" mass="60394" checksum="4CE8C81489B356FA" modified="2016-03-16" version="1">MSDTIGDRISFEGNCCTIKYIGPVKGVEGQWLGVEWDDPSRGKHNGTYLGENYFKCRKENSGSFIRQNRPRDIKKTFVDAFIDKYGDRNVEEYINFDIKSKNTNINPKIQEIYHPKNIQKKLPKRYIVTLDHMAISELGNIGEIKKKCSDILEIDLSGNLLNWKTVILIIKELPNLSSLKLNYNQLGTSELILSNNFKFSNLKTLILNKTYLKIKEIKKLCISFENLEELQISHNLLTLKTNNDFHFSDTIPHLKKIFLNDNKISCFETVTRIFGKLEKLVFLSLASNQINTINIIPNTFISLKYLDISKNNISEQTSLNNLNILHSLVSLRFTDNPLLKEFKSNPSTFIIPRLRNVMIINGTKITQEERQNAELYYLSTIEKEIKSGKISNYSDLIKEHPQWRELQKKYEKENPIFNTEKNLTEKIIENKLIELYIIFEKEIIKKKFISSMNIRSFRSFCAKFFKINPFDFTISYLEGSYKIIYIDDDSKLLSFYNLTSGETIYIKQNKPENYTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7NHI9</accession>
    <name>M7NHI9_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_03472</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875560.1">
        <property type="nucleotide sequence ID" value="XM_007877369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NHI9"/>
    <dbReference type="STRING" id="1069680.M7NHI9"/>
    <dbReference type="GeneID" id="19897159"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03472"/>
    <dbReference type="eggNOG" id="KOG2169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IEPNGDW"/>
    <dbReference type="OrthoDB" id="28127at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16792">
        <property type="entry name" value="SP-RING_Siz-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.780">
        <property type="entry name" value="PINIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023321">
        <property type="entry name" value="PINIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038654">
        <property type="entry name" value="PINIT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031141">
        <property type="entry name" value="SIZ1/2_SP-RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14324">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51466">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SAP" evidence="12">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="PINIT" evidence="14">
        <location>
            <begin position="104"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="SP-RING-type" evidence="13">
        <location>
            <begin position="284"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR08028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="588" mass="66372" checksum="82239B191E7EAE5E" modified="2013-05-29" version="1">MQYSPPFQNYPLIIHHLENRLLVTTLRAILKEYGLPISGKKYILITRIREFLDKVVETKDIVQYERLKNSIMGIHLHPIPSYVVSYTSKNLPIMSSTPLELPISEPALSLPTINVFQRINFKPSPFYNILENINSPIICPPMLRNIITASVRLSLKAVEKLASNESYRVYLFCTATDSAAFGLALIEFPVHMDLKVNGKHLSANTRGLKKKPGTAPPVDVTSLLFLDSKLVNKIEIIYANTEKRYSFGVYLVQKYTICDIIQHIKAGRCLSKQTILDTIKKDSEDGDIIATSYDISLKDPISYTRIELPCRSIYCNHVQCFDAYSFLTLNEQTPTWQCPICNKPIHAIDDLAIDSYTLEILNSVSLSVESVTIDLNGTWFITKSNIGNELSDSNNNEDISKKHNTFYMDPNNHETSLEQNHSVLSSSKSLYKRSEPTVIDLTLDSDDESPMQSPLHKKCRNNSVDTQSETLSSDFQFPKFHLNLASISHLPKACFFDSNVSESGHPISTDIIPVDQSLNNSVKLSTLESEHSTVLYKSLADNNTKDINNSSAFLGPFSNDLWSNKDNSCAWQEEFRENNCIDIHSTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NHQ1</accession>
    <name>M7NHQ1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_03538</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875630.1">
        <property type="nucleotide sequence ID" value="XM_007877439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NHQ1"/>
    <dbReference type="STRING" id="1069680.M7NHQ1"/>
    <dbReference type="GeneID" id="19897225"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03538"/>
    <dbReference type="eggNOG" id="KOG2001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007738_0_1_1"/>
    <dbReference type="OMA" id="QNMSGDP"/>
    <dbReference type="OrthoDB" id="2192946at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000923">
        <property type="term" value="C:equatorial microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000931">
        <property type="term" value="C:gamma-tubulin ring complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008275">
        <property type="term" value="C:gamma-tubulin small complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061496">
        <property type="term" value="C:half bridge of mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061497">
        <property type="term" value="C:inner plaque of mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031021">
        <property type="term" value="C:interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035974">
        <property type="term" value="C:meiotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071957">
        <property type="term" value="C:old mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990734">
        <property type="term" value="P:astral microtubule anchoring at mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098863">
        <property type="term" value="P:nuclear migration by microtubule mediated pushing forces"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000011">
        <property type="entry name" value="Spindle pole body component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF13">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="130"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="465"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="819" mass="94278" checksum="543F8D465FD3B49E" modified="2013-05-29" version="1">MRRSSSPPSSNISGFPRRQSLRSSMNESQPLELVLNNGSYDQKAPLEALTNSPLNQERKSDTDSNSLYEGQGRILSSLKKDKTYVPVYELNRAIRSTAPLAKQITVSFSAPPSFSFEGVSPNLQEVFLMDDLLLVLMGIEGRFIRYQNEEDRWDDNNRLAGVKFRISSGVEPCLLDLTRMILKVATCYISIDAFIDIYSKPECGLVNHALCAAMRELLKGYFTLIAQLEHQFNTNPSFTIHTFHLYMHSTSQSLFGMQALIHDILKKSCVLDEENSDDSIDDVDSFLRSIQDKGITSIVNSKVCKGGSVLEVITNRLLSLSGDPRAKKLLEYLLKETSKPYMKMLNAWMHRGEIRDPQSEFMIKEQKSIKKDRLEDDYIDEYWEKRYTIRDNEVPSQLEPVKTKVLVAGKYLNVVRECGGINISKDLSDNMPSTFDDIRFLDSVNAAYAHADASLLKLLLETHGLSSRFLSLKHYFFLHQSDFFTYFLDLASHELKKLVKDISLTKLQSLLDISIRIPGSIASNDPFKEDIKVQMSNVGLVEWLMKIVSLSGIDETAIAAGTIWIDDYQSQTYSTEKKDKEFTGINGLQFDYFVPFPLSLIISRKAVLRYQLIFRHLLSMRHLEQLLGSAWLDHSKNMSWKKYSICSQVEKWKNRVWLLRSKMLNFVQQLFYYCTNEVMEPNWLIFQKRLSKILTVDQLMQDHIDFLDACLKECMLTNSKLLRVQAKLMTTCTMFASNTKYLTRSLASVEDNNSTEPQIDFVKMKKLDDILHKYEENFSHHLKILLDTCNYFAKTETVSLLSLIIRLDWKESRELSDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NHT3</accession>
    <name>M7NHT3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Monopolin complex subunit Csm1/Pcs1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_03566</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875659.1">
        <property type="nucleotide sequence ID" value="XM_007877468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NHT3"/>
    <dbReference type="STRING" id="1069680.M7NHT3"/>
    <dbReference type="GeneID" id="19897253"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03566"/>
    <dbReference type="eggNOG" id="ENOG502R6WM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_790154_0_0_1"/>
    <dbReference type="OMA" id="FYARVIK"/>
    <dbReference type="OrthoDB" id="2431049at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034506">
        <property type="term" value="C:chromosome, centromeric core domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033551">
        <property type="term" value="C:monopolin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990644">
        <property type="term" value="F:microtubule site clamp"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045144">
        <property type="term" value="P:meiotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23787">
        <property type="entry name" value="RWD_CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.80:FF:000001">
        <property type="entry name" value="Chromosome segregation protein (Pcs1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040349">
        <property type="entry name" value="Csm1/Pcs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020981">
        <property type="entry name" value="Csm1/Pcs1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038608">
        <property type="entry name" value="Csm1/Pcs1_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28006">
        <property type="entry name" value="MONOPOLIN COMPLEX SUBUNIT CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28006:SF1">
        <property type="entry name" value="MONOPOLIN COMPLEX SUBUNIT CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12539">
        <property type="entry name" value="Csm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Monopolin complex subunit Csm1/Pcs1 C-terminal" evidence="2">
        <location>
            <begin position="248"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="200"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="351" mass="41111" checksum="EF4229B757C7F7D3" modified="2013-05-29" version="1">MRKKHTNISKNKERKHTIDCDFSFNEQDDSIDELASSLKSKRNHTNKETPLRKISNIGKFDLSEKENIFSRYSETIEANSCKKRFEKGTTLENNSKGSQKHVQQEVLQIRQNDSKRKFLDIYDENIDMEKRLEETIRKMEEFEEKYNCLKNLRQTEVESNFLAYQEIAESRFKASQALIDSLTKDMDIKDKRLNELSSCLVDLKAQKKEFEKISENLKSTEQALNHAKSQISYLNTKLSSRSKLSMVQLKEELYSDLTGLLIRDVKSDSKKTVFDCLQTGRNGTLHFKLSLFSDPSSHLHERFSYTPLFDQERDAFLLNCLPEYLTDEIIFEKDQAAMFSWRLSSALQKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>M7NIG3</accession>
    <name>M7NIG3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 3-kinase VPS34</fullName>
            <ecNumber evidence="7">2.7.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_03203</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:12710"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="7"/>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875266.1">
        <property type="nucleotide sequence ID" value="XM_007877075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NIG3"/>
    <dbReference type="STRING" id="1069680.M7NIG3"/>
    <dbReference type="GeneID" id="19896890"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03203"/>
    <dbReference type="eggNOG" id="KOG0906">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004869_0_0_1"/>
    <dbReference type="OMA" id="LHKFAQY"/>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032120">
        <property type="term" value="P:ascospore-type prospore membrane formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051365">
        <property type="term" value="P:cellular response to potassium ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08397">
        <property type="entry name" value="C2_PI3K_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00870">
        <property type="entry name" value="PI3Ka_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00896">
        <property type="entry name" value="PI3Kc_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 3-kinase VPS34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057756">
        <property type="entry name" value="PI3-kinase_type3/VPS34_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008290">
        <property type="entry name" value="PI3K_Vps34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000587">
        <property type="entry name" value="PI3K_Vps34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00142">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2 PI3K-type" evidence="10">
        <location>
            <begin position="25"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="8">
        <location>
            <begin position="537"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR08363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="834" mass="96041" checksum="6BECFFC0061B3707" modified="2013-05-29" version="1">MGNSTYSFCTSSQLHFPIHIKIGTIEGNLSAIFNTIDYLKNQNENIKDFFPDLFVTVQLYSDNKALTLPSRTRYKNFKYKKIWNEWLSFPLNYSDLPLNAQFAIVINDAYGSKLNKPFASTTVKLFSPDKTLKMGLQKLNLFIGIPADGNNNSCTSNDISFQNEMNHLEMLVKKYEAGDIQKVKWLDNLAFHQIEKIQQKHLDKLESLVLCIDFPQFDFPILFSEYEYPATLAFSFNEKPSSSKLILTPPDPELFRENLIETKYRCLIRSHKNGPLDRELKPNSNIRDQLNIIMTFPPTQELTSEEKDLIWKFRFYLTRDKRALAKFLKAVVWTDVVEVKQAHDLLRLWTEIDIDDALELLGPGFRDDIVRGYAVDRLRKADDEDLMLYLLQLVQALRFENPILEISKINNYPSSLAYFLIERAIKNEVLGINFYWYLMVECEDKTGGKLFSEIAYQFMANLMEVPNGLMRQNILKRQAELLASLLFISKEVRSIKESRPKKIERLRYYLSNPDNRLIKFEPLSLPLDPSISVVGIIPAESTVFKSSLLPLLICFKTTTGSLYPIIFKNGDDLRQDQLVIQMVSLMDKLLRNENLDLKLTPYKILATGVNHGAVQFIQSKSLMSCLTEYHGSILAYFRSNSPDNSSELGVKAEVMDTYVKSCAGYCVITYLLGVGDRHLDNLLLCPDGMIFNIFIFSYNIIGHFFHADFGFILGRDPKPFSPAMKLCKEMVEGMGGASSSYYSQFKSYCYTAFITLRKSANLIINLFALMLESNISDIKFEPDKSVLKVKERFCLEMTDEEAIKYFQQLINDSVSAFFPVLIDRVHNIAQYWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NIV6</accession>
    <name>M7NIV6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_03019</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875070.1">
        <property type="nucleotide sequence ID" value="XM_007876879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NIV6"/>
    <dbReference type="STRING" id="1069680.M7NIV6"/>
    <dbReference type="GeneID" id="19896706"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03019"/>
    <dbReference type="eggNOG" id="KOG1318">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1289412_0_0_1"/>
    <dbReference type="OrthoDB" id="71302at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11398">
        <property type="entry name" value="bHLHzip_scCBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047206">
        <property type="entry name" value="bHLHzip_scCBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787:SF1">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="4">
        <location>
            <begin position="91"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="214" mass="24760" checksum="C7C5FE857DEE55AF" modified="2013-05-29" version="1">MTLKHLKKQNQRVEKVYRTEDSLSKEFHGLSEITRYTGMNGEDDDDDEGGGIYSVETGEEILKSTVIRREEDLHEAGGHKPMVGSEEWHRLRRSNHKEVERRRRETINESISELARIVPGCEKNKGKILERTVAYIQQLKENEANNIEKWTLEKLLTDQAISELSATNQKLKAECDRLWREVNVWKQAAASGLNNDKDEKKDDPISNVRAEKMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJ26</accession>
    <name>M7NJ26_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">GTP-binding protein ypt5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_03094</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875150.1">
        <property type="nucleotide sequence ID" value="XM_007876959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJ26"/>
    <dbReference type="STRING" id="1069680.M7NJ26"/>
    <dbReference type="GeneID" id="19896781"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03094"/>
    <dbReference type="eggNOG" id="KOG0092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_10_2_1"/>
    <dbReference type="OMA" id="DEEGLMW"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000464">
        <property type="entry name" value="GTP-binding protein ypt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR08618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="201" mass="22384" checksum="00899CE502C8DA0A" modified="2013-05-29" version="1">MESQLFSAKLVLLGESASSLVLRFVKDQFDDYRESTIGAAFLTQTLSLDKTTTIKFEIWDTAGQERYRSLAPMYYRNANCAIVVYDITQAESLDKAKAWVKELHRQACGNIIIALAGNKADLSERRAIEIEDAQAYAQEEGLIFFETSAKSAQNVNELFHCIAKALPLEHPTHKPRSAGLTRDVDLSRRSSVVNASSTCNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJL4</accession>
    <name>M7NJL4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase kinase kinase</fullName>
            <ecNumber evidence="2">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_02958</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875003.1">
        <property type="nucleotide sequence ID" value="XM_007876812.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NJL4"/>
    <dbReference type="GeneID" id="19896645"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02958"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_253301_0_0_1"/>
    <dbReference type="OMA" id="SKEICEW"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000182">
        <property type="entry name" value="MAP kinase kinase kinase mkh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF48">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE BCK1_SLK1_SSP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1127"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="1156"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR08788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1417" mass="166829" checksum="E5E4BBCA13DF722D" modified="2013-05-29" version="1">MGFSNQSEDLNTGERKIVFHWRRHRRCLDVYIKKKKLKQCDEFLRKHLKDIKNTEETNNLKQNCLDMVKIPIETKTNLLQNNISMKEALIYSSKEICEWLYQNEFNIENQKISFDNNIFNGSLLNPFNCFRIMEFLPFESQRKNLKLYHTINIPSNYNTMDNNEKYYLKDMKLFIQKNPSLICKKGTVESLIISSLIKLHEDNNQKLMKFYIFWNNSFRNNNDLKMEDFHRFEKTNNLHKMLKYDEYTENSWNNSSIILFDNDMELNLLNESKFLTSSFHQKETYNSEDLLEAFRIPEYFEFGLSDSSIDKKSIFYVINDYDEEFSFYISLISKTDQFQNSNFYKTAFHKSKNVKKKSSFLYKKKYLSYYFNIYWKFFRFFHKKITSMGFSNSKDYQNCKCNVLNKETKSNKSLNNINTSKKLNLILSNIFNTLTENCKSLWIPKIITLKNREFTLKLTKIVQITRDRQTFIIVDLTKYINAIDIRKQLCKKLGIVESWSKCRIFIIEIYNNEYEEELNDEKLVLARFYADSLGSLKFFIELSSKEIDKRNNNDIIPVYSTPNNDFFKIFSNILSKKTDLEFNKIQLNNPISKWSDNDIILIEDLNYRLGNQDFHEKLKDENKKTNLFSVSKNDQDNFFIKKNQNNINIKSGPLLNKVFNLSEYSKFLNNIHYHINDRKKINIKEIQLKLGKSCISKNFLFILEETFPLNLKRKLIEKLFNTENKSNYRKKDDLILANGNELKRIACDFKNSFFFSTELNNQHSYSYDKNIYGFLFNKEIIQKLLNIKFSITENISIADIDSYDKNIFRTYGSSENSCSKENIISFNNELGSKELFPDFFNLKLNIPRSFFEDKMISNIKTFSDINRESAFKEFIDLSDDNSVSIGGIENEQEMFWAVKPKKIADKITSNELNNSDTNYSSNYKSERNTPLNTLDIINILDTHKKRIVFNKFSKPSLESENIENNLHNSILYKSSVTLSKDIFEEKNLCYNDKWEIRPSTQVVYDNLEDFFPNHDLDKPIINQLADFIDFLGIDNISDIFLVFLRTIFSDYNFNIENCMKSIKIVAKEASESQKKYENNITNKNPIPRKKSTKLWGVKLQEMKLNKDKDDYNFKKTCSIKRTPTFKWIKGKLIGKGRYGEVYLAMNATTGEMLAVKQVKLYHNLDNQDNEYQKELINALNKEIETMKDLDHPNIVQYLGFESTKTTISIFLEYVSGGSIGRCIRKYGKIDQQTIQLFTRQILEGLTYLHSQGILHRDLKTDNILLDVDGICKISDFGISKKSKEVYDNDSNMSMQGTIFWMAPEVIHNQKQGYSAKIDIWSLGCLVLEMFAGKRPWSDDEAIGVMFKVGNEHLAPPIPHDIQQNIKSDALDFLKLCFIVDPSLRPTARQLLSHPFIKNADSNFKFSDSSLSQIIKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJT4</accession>
    <name>M7NJT4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial</fullName>
            <ecNumber evidence="5">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_02663</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="5"/>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874684.1">
        <property type="nucleotide sequence ID" value="XM_007876493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJT4"/>
    <dbReference type="STRING" id="1069680.M7NJT4"/>
    <dbReference type="GeneID" id="19896354"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02663"/>
    <dbReference type="eggNOG" id="KOG0784">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_0_1"/>
    <dbReference type="OMA" id="TCAHKAN"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045242">
        <property type="term" value="C:isocitrate dehydrogenase complex (NAD+)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF42">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="13">
        <location>
            <begin position="27"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR08878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="361" mass="39597" checksum="EE78D94C0B27FF40" modified="2013-05-29" version="1">MKSTRCVIGKPSLFSRSIANKIGGRYTVTLIPGDGIGKEISESVKTIFKSQRVPIDFEQIDVTGKIKPDGENDLFKQSIESLKRNKIGLKGILYTPLECSDHSSFNVSLRKIILLANLTLIKNIPGCQTSHNNVDFVIIRENTEGEYSGLEHQSVPGVVESLKIITRTKSERISRFAFDFALKNNRKKVTVVHKANIMKLGDGLFRKTFFEIAKDYPQIEATDLIVDNASMQAVSNPQQFDVLVTPNLYGSILSNIGAALVGGPGLIPSANYGEEYALFEPGCRHVGLDIAGKDRANPTALILSSTMLLRHLSLDDYASAIERAVYDVILEGTVRTPDMKGTSSTTAFTNAILDRLNQSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLM0</accession>
    <name>M7NLM0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_03532</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875624.1">
        <property type="nucleotide sequence ID" value="XM_007877433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLM0"/>
    <dbReference type="STRING" id="1069680.M7NLM0"/>
    <dbReference type="GeneID" id="19897219"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03532"/>
    <dbReference type="eggNOG" id="KOG1865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008279_10_0_1"/>
    <dbReference type="OMA" id="QQANKAW"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000119">
        <property type="entry name" value="Ubiquitin specific peptidase 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF758">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="100"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="466" mass="53604" checksum="1F6D0D7B65AB025C" modified="2013-05-29" version="1">MEEAVVKTDSSSYFDLQSLLKNPVRFGPCFIEPLGHWDTLYTPVNIVESINNTATDTQVVHSFESPQSSDSESPIARPSIVLFSSDQLLHSWTCIRPPAPGLINVGNTCYLNSVLQILSHVPPFVQYLLAGHHSSQCQMSACIFCKMEKHVAQCYPSDGSRPVRAFKPLHIVGALKWISKRFQPYRQEDAHEFLRCLLGEMQRSCIYPYKDLDFASQETTVIYKIFGGYLRQQVKCLKCNDISNTYPVYLDLSLDLMGTSIEEALDMYVREEMLTQSNRYKCEKCKILVDFQKKSSIYILPPILTLHLKRFSFNKAFKMSKITRHIRYGETLELTSYMSQKKQNPIIYDLIGIIVHSGNDTRCGHYYSFCKTSNGTWLHFNDDMVSTVSLQTVLKQQAYILLYSRSNSSKYTDFNNFSKMLFSFNSLDKIQFHKQNHNSDSNQETFKRLKYDNNLSSTIEDTGVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLW6</accession>
    <name>M7NLW6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_01853</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873824.1">
        <property type="nucleotide sequence ID" value="XM_007875633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLW6"/>
    <dbReference type="STRING" id="1069680.M7NLW6"/>
    <dbReference type="GeneID" id="19895547"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01853"/>
    <dbReference type="eggNOG" id="KOG1691">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066963_3_0_1"/>
    <dbReference type="OMA" id="DVFEACF"/>
    <dbReference type="OrthoDB" id="759142at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="9">
        <location>
            <begin position="40"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR09663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="221" mass="25546" checksum="A5A44033EEA6BD5B" modified="2013-05-29" version="1">MFLFARIQVLLSLILFFSAFASVFSLMFDIIAMPKNIENNRCIRTYVPADTLVTIHVNVFGSLNDGQKVNMTITDIAGNKYGHSREIIGQRKIVLTTNNESTIIVCLNNVLLDGFDSTFNHFRSVELNINKGADALNWNEIEIQKHLKPIEVELLRIEGISKEIAKEMNYMERREQKMRDINESTNDRVKYYGLGFMISLVILGVCEIVYLRRFFQRKQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLZ2</accession>
    <name>M7NLZ2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial Rho GTPase</fullName>
            <ecNumber evidence="15">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PNEG_03386</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 15">Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Mitochondrion outer membrane</location>
            <topology evidence="2 15">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the mitochondrial Rho GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="15"/>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08217.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613283.1">
        <property type="nucleotide sequence ID" value="XM_019757755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLZ2"/>
    <dbReference type="STRING" id="1069680.M7NLZ2"/>
    <dbReference type="GeneID" id="19897073"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03386"/>
    <dbReference type="eggNOG" id="KOG1707">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014255_3_0_1"/>
    <dbReference type="OMA" id="HETTWGI"/>
    <dbReference type="OrthoDB" id="10020961at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015886">
        <property type="term" value="P:heme transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055091">
        <property type="term" value="P:phospholipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010821">
        <property type="term" value="P:regulation of mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01892">
        <property type="entry name" value="Miro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000011">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000553">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013566">
        <property type="entry name" value="EF_hand_assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013567">
        <property type="entry name" value="EF_hand_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021181">
        <property type="entry name" value="Miro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052266">
        <property type="entry name" value="Miro-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020860">
        <property type="entry name" value="MIRO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08355">
        <property type="entry name" value="EF_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08356">
        <property type="entry name" value="EF_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037488">
        <property type="entry name" value="Mt_Rho_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51423">
        <property type="entry name" value="MIRO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 15" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="590"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="18">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="296"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="18">
        <location>
            <begin position="410"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMR08217.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="615" mass="69555" checksum="D171BD81D0190C9B" modified="2016-03-16" version="2">MTDIRIVVVGDDHVGKSSLITSLVKVVKENVIPPISVPDIYSNTNTIIVDTSSDPVDRPVLIKELRKANVICLVYADSYSEERISLFWLPFFRSLGVNLPVVLCANKCDNLEKDGSQVIEEEMLPIMKEFKEVESCIRSSGKTHKNVNEVFYLCQRAVTHPIAPLFNVKEQDLKPAAIVALKRIFFLSDKDHDGILNDTELDSLQRRCFEKSMTQSDFDDIKFSVSKLSSEAIRNNGLTETGFLMLNKLFSIKGRHETTWQILRSFKYTDSLSLKDDFLNPKVEVRSDQSVELSPLGYRFLVDYFSLMDKDNDGALNSDELNALFVSTPGLPKLWLLSSFPDSTVRNEMGYVTYNGWLAQWSMTTLLDYPTTLAYFAYLGFESPGKEGTIDALHLTKPRKRGKKSVKVDRNVFLCYVVGKRKSGKSCLLDSFINTPYNPKYIPTKGHRIVVNSVEIQSIQRYLVLEELTDNESSVLSNPKKIDSCDVLCLTYDSSDPESFGYLLKLHEKYPEINSIPCVYAATKADLDRQQQRCDIQPDQYTQAQCLRSPIHVSIPWMSTSDLFVQLVEAAQAPYSATPRKKTESETSNIAFLLATTVFGTLVLSIGVHLFFRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NM73</accession>
    <name>M7NM73_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Vacuolar protein sorting-associated protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_03404</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endosome membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1 10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the VPS27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875489.1">
        <property type="nucleotide sequence ID" value="XM_007877298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NM73"/>
    <dbReference type="STRING" id="1069680.M7NM73"/>
    <dbReference type="GeneID" id="19897091"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03404"/>
    <dbReference type="eggNOG" id="KOG1818">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011862_1_0_1"/>
    <dbReference type="OMA" id="HTWGGNT"/>
    <dbReference type="OrthoDB" id="957735at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15735">
        <property type="entry name" value="FYVE_spVPS27p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21385">
        <property type="entry name" value="GAT_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16979">
        <property type="entry name" value="VHS_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017073">
        <property type="entry name" value="HGS/VPS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049425">
        <property type="entry name" value="Vps27_GAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21356">
        <property type="entry name" value="Vps27_GAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036956">
        <property type="entry name" value="Hrs_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0967">Endosome</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VHS" evidence="14">
        <location>
            <begin position="19"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="13">
        <location>
            <begin position="173"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="521"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="533"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR08236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="559" mass="63982" checksum="715E86371AC69203" modified="2013-05-29" version="1">MLSWWTFRAFDELVEKATSEDIPAGIEDLTSCLEICDKIRSKSVPSKDAMRSLKRRMAHKSANVQILTLKLIDLCVKNGGDHFLLEISSREFMDNLVSLLKTNKTTEHDVTAKADVRKKILELIQVWAVLFEKKKHLGYVCTVYEDLQSQGYEFPPKEPLNSTFIDSFSPPEWSDSSICMLCRTRFTFKNRKHHCRNCGGTFCQSCSSKSRPLLYIGIIEPARVCDNCYSKKTQTPAISMPNNVLDMENPKNTNIDDDSDLKYAIKLSLEESKLQESKFQQDFPKDHKRQYSDDEDLKKAISLSLKESEQSKSVSFTPNVKTIVPDLQPKFEHELTALEIENINTFCMLIQKLQMAPIGSILRDHYVQELHDSVIKLKPKLIRSLGNTISKYEKLIDIHSKLSTVMKYYDKLLEDRLSTAYSRHHVSSIHEKSSLHPFNQTYDPSLLTPTSSMPSEYYSHYKELRQQKNTSFYSSYIPSQHASSTSISPSKEIISSTIPNYSSNTFSQDTFTNKPSSTFIKDSCSPIHDQHNPNHSSLHQKNPLQDKTEPSTQVSLIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMI9</accession>
    <name>M7NMI9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873610.1">
        <property type="nucleotide sequence ID" value="XM_007875419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMI9"/>
    <dbReference type="STRING" id="1069680.M7NMI9"/>
    <dbReference type="GeneID" id="19895344"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01650"/>
    <dbReference type="eggNOG" id="KOG4208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025741_0_1_1"/>
    <dbReference type="OrthoDB" id="21467at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12307">
        <property type="entry name" value="RRM_NIFK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46754">
        <property type="entry name" value="MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="147"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="293" mass="34853" checksum="F871C2AC90FFA732" modified="2013-05-29" version="1">MSKKRKIQENLQVSKREPSIQKTILLNKNEIELKLKKKRKLNNIIKKSEYKSEKHRSFDKDSKNVDENESLLDQNYKKNFQINHTSNINGLLLDSDSNMLNNTDSYSSKRFESDDFDNKKSLSQDAIFLKNKIIQKKSFQNIHELSKVIYLGRIPHGFYELEMKNYFEQFGAVTRIKLSRNRKTGKSKHYAFIEFESSDVARIVAKTMNNYLLFGHILKCSVVSKEKLHKSIFIGANRRFKPIPWSRITIKRLEEAKTKEQWIRLQKRNNKRLKKKMKLLKKLGINYQYNKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMK3</accession>
    <name>M7NMK3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phospholipid:diacylglycerol acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08452.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613288.1">
        <property type="nucleotide sequence ID" value="XM_019757754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMK3"/>
    <dbReference type="STRING" id="1069680.M7NMK3"/>
    <dbReference type="GeneID" id="19896969"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03282"/>
    <dbReference type="eggNOG" id="KOG2369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016065_1_0_1"/>
    <dbReference type="OMA" id="FYFLKWV"/>
    <dbReference type="OrthoDB" id="190846at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046027">
        <property type="term" value="F:phospholipid:diacylglycerol acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006672">
        <property type="term" value="P:ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055091">
        <property type="term" value="P:phospholipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08452.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="679" mass="77130" checksum="8D68D352573A7F51" modified="2016-03-16" version="2">MFNKDKEVKVSLESSSVKSRSGFLRNRLSKIAHVKNSLPIKQKNIFKDSDFKRHFVQYRRVVFVFGIIVGAVITGIFIKRSNIVDFDWDFLLGFTDIGDFMEELRNILPASVFDDAKKLSYYDKDSDYEAFFVGNRLREQGYKPYFNVIIVPGVISTGLESWSTSNCSSLPYFRKRLWGSWTMLRAMLMDKKCWVSQLMLNETTGLDPEGVKLRAAQGLSAADFFVTGYWIWNKIIENLAAIGYDPNNMFSAAYDWRLSFLNLEERGIFQYFFMNNGLSMFLRSLFHQASIEIAKATSGKKSVIISHSMGSQLTLWFLKWVEADGYGNGGKSWVNDHIEAFINISGSLLGTPKAVTALLSGEVKDTTQLNAISVYGLERFFSKFERVQLLRSLPGIASMLPKGENVIWGNATWAPDDLYISNVYNLSFGSFINFRKNSKTSILKNLTMSDSMDYLISQTSHTFHKMLSTNYSHGISWTEKSIEMNNNRPEKWINPLEVSLPNAPNMKIYCIGKPTERAYWYDEGPKDSNLSKDSAKVDLCDCINNTMRIFSDPDIFGQTPFIDNTVNIKPYTEKGVVMGEGDGTVNILSTGFMCVKGWKQRRYNPANISVIVHEMLHQPDRHGLRGGSKTADHVDILGRSELNELILRIVSGNGDTLLKNKILSNIMHYSDQINIDNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNJ7</accession>
    <name>M7NNJ7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Pre-mRNA-processing protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SNW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873463.1">
        <property type="nucleotide sequence ID" value="XM_007875272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNJ7"/>
    <dbReference type="STRING" id="1069680.M7NNJ7"/>
    <dbReference type="GeneID" id="19895215"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01520"/>
    <dbReference type="eggNOG" id="KOG2441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YGQRRGW"/>
    <dbReference type="OrthoDB" id="666364at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017862">
        <property type="entry name" value="SKI-int_prot_SKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004015">
        <property type="entry name" value="SKI-int_prot_SKIP_SNW-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12096">
        <property type="entry name" value="NUCLEAR PROTEIN SKIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02731">
        <property type="entry name" value="SKIP_SNW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SKI-interacting protein SKIP SNW" evidence="5">
        <location>
            <begin position="185"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="342"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="545"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="552"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="565" mass="64093" checksum="4C11EFC48E52B1B9" modified="2013-05-29" version="1">MKVAFPPVFGKETRHLNGEKAVLKEAFLGSKVENKEINQNGLISTKIPPYGQREGWIPKRIEDFEDGGAFPEILVAQYPLQMGLKKMTAGAALAIQVDAEGNIRYDAIARQGHDPDRIVHSSFKSLIPLRQRADIGEISLERPSIEEVEATTERTRRALEKIITGQIAASKPKTIQTQEKHEPTFVRYTPCNQMGETADVVHRQRIIKMVEMPQDPMEPLKFRHKKIPRGPPSPPAPVMHSPPRKLTAKEQQEWVIPPSISNWKNAKGYTIPLDKRLIADGRGMMDVQINDNFSKLSEALYAADRHAREEVRKRAQMQHKIAQKEKDAKKEHLQELARKVREERHMLQQKDSSNASEATRSDEDENSEDERAAKERENLRRERRRDVERQMRMSRMGAEQRLKVMAREQNRDISEKIALGLAKPTLSKDSLFDNRLFNQTAGLDSGFKDDDTYNIYDKPLFATAAAVQSIYRPKANDVDENPDEELNRVTRESRFEVLGKATHGFKGADLAEPRDGPVQFEKDSDPFGIDAFIASAAASAYAKRNLGLDTSTTKDSKKTKLENSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNS7</accession>
    <name>M7NNS7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01596</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873553.1">
        <property type="nucleotide sequence ID" value="XM_007875362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNS7"/>
    <dbReference type="STRING" id="1069680.M7NNS7"/>
    <dbReference type="GeneID" id="19895291"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01596"/>
    <dbReference type="eggNOG" id="KOG1446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044117_3_0_1"/>
    <dbReference type="OMA" id="HNEGYIR"/>
    <dbReference type="OrthoDB" id="27537at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990567">
        <property type="term" value="C:DPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090052">
        <property type="term" value="P:regulation of pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902801">
        <property type="term" value="P:regulation of siRNA-independent facultative heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031126">
        <property type="term" value="P:sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001194">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.1, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="108"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="266"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="37914" checksum="8520926F8D5B6994" modified="2013-05-29" version="1">MGTVVVSEQVLSSLRPSKGFKNHQEGTAITCVDFDDTGEWLITSGEDESLQLYDCILGKHKKTLYSKKYGIDLARFTHRSTNVIYSSTKDDDTLRYLSLHDNVYIRYFRGHKKRVISLDMSPLDDQFISGGLDNSVRLWDLRSSTCQGLLNISTPCLAVFDPTGIIFAVASHPLSSILLYDLRNYDKEPFSTFSLNDDGFLSKISYPPRMPDWIKLEFSNDGKLILIGTRGEGHYLLDAFSGELQSRLTGHVPVNSDPKSITSGDVCFTPDGRYIIGASGDKNVVIWDTKQINRSKSLTPVQILNSGNIGPAKVVTFNPRKMMLVTANNTLAFWLSENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNU6</accession>
    <name>M7NNU6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GrpE protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02713</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874738.1">
        <property type="nucleotide sequence ID" value="XM_007876547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNU6"/>
    <dbReference type="STRING" id="1069680.M7NNU6"/>
    <dbReference type="GeneID" id="19896404"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02713"/>
    <dbReference type="eggNOG" id="KOG3003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057217_0_0_1"/>
    <dbReference type="OMA" id="QHELICH"/>
    <dbReference type="OrthoDB" id="201635at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.22.10:FF:000002">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="234" mass="26845" checksum="D3C069597B55340A" modified="2013-05-29" version="1">MFFLLRPCRMKHVLCVRVVEARKFGFKRAFWSHLMLNSEESKLEGQKLEEGMNEASDLRNQKPIVDISPSIAEKSRDFTVDAEKEIARLKDKYLRSVADFRNLQMRMQKEVEDAKLFAIQQFAKDLINSVDNLERALALIPEDSRTDVEKNKQLVDLYTGLKMTETVLNKTLEKHGLVKYDGLGEKFNPNLHEAVYQALVPGKEAGTVFHNEQTGFILNGRVIRPAKVGVVKEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPG6</accession>
    <name>M7NPG6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02767</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874797.1">
        <property type="nucleotide sequence ID" value="XM_007876606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPG6"/>
    <dbReference type="STRING" id="1069680.M7NPG6"/>
    <dbReference type="GeneID" id="19896456"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02767"/>
    <dbReference type="eggNOG" id="KOG3589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013365_1_0_1"/>
    <dbReference type="OMA" id="DPGMRYL"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058855">
        <property type="entry name" value="RGS1/SST2-like_Fungal-DR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25889">
        <property type="entry name" value="WHD_Fungal_DR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0734">Signal transduction inhibitor</keyword>
    <feature type="domain" description="DEP" evidence="3">
        <location>
            <begin position="227"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="372"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="60618" checksum="31FC48C5371AA331" modified="2013-05-29" version="1">MHQSSTRLMRMTADGRPFTNDYKDLFSTLIASLSLNTHRVHFKTFPFSFTTEEALANLRYLKLTHSTRLPDAKDPSRILVTTSTTTFSMAEDIAKLLCQRFILSHFIESVNEKNLTIFKDKAIWKLTPKGIAIVSRFVKRNGVDTPVINDLLASPYNTMQLVILERDPETDAILQDPFMIEIIFRHFVGIKPNIVSSNIQDSPDDYTDGIVGVRIIEQKFIESSRYCFNGLSAFLWLMRCCTTITYREAIEIATIFINQNLIIRENTESPSKSDSFKFSSSKNDIYMLTDKGFSISGWKDLDVYSISTVTTKSKFFFIGANRKKQTTIKNIRPKIIQKTDPESYLTFQKDIFYDINTGLLNNETNHKRLFIILNDPALRFQFRIFLQENYCEENLSFYFESIQFFQLAEHAIDPISIQESLTKAYDIYNAFLVEGSPCELNLDYALKQSLADCMTTIVLNDNETMKNTLDSVVKLFDKAQKQILRLMARDSVPKFLQSATQLKNDTNQFQEFMKPTFSTHPISQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPW3</accession>
    <name>M7NPW3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874232.1">
        <property type="nucleotide sequence ID" value="XM_007876041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPW3"/>
    <dbReference type="STRING" id="1069680.M7NPW3"/>
    <dbReference type="GeneID" id="19895938"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02245"/>
    <dbReference type="eggNOG" id="KOG2138">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MIQFVRK"/>
    <dbReference type="OrthoDB" id="20507at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011666">
        <property type="entry name" value="DUF1604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384:SF19">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07713">
        <property type="entry name" value="DUF1604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26093">
        <property type="entry name" value="HTH_TGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="632" mass="71920" checksum="D52307A7E77EEDF3" modified="2013-05-29" version="1">MESSRKKPRIDEDKQDYVFFGTSIIGSDGIEEGKYEPIWRQEVRDERGRRRLHGAFTGGFVAGYFNTVGSKEGWTPQSFRSSRKERAILKISKAEDYMDAEDLAERDEERHLKTKDDFIGIGCEDVNQEKKGSILDDLIIKKESIGIRLLKKMGWKEGQGVGPLVKRSKLDDDETDDEYASEFLFSPKDSIMDFFKNKTDLYGLGYVPAPAIERLQHITDNNTPKFGISGISFGYGVLNEDDNEYDYEVYDFGPSKIKYDTVLDHEEKKKNTSNTKLKPVTKHLFVPRKKNTVGIEVRRCQDGSLPLNGFILSEVYRIEKKAWFDPPVVPSDYVPCAPHSERKVISGNFLQPRDRGAILGETPLPGKSVFDFLSSSARERMVQATGRTDLPPARNEGAITREDSKSSIPLIDKKMALDALNNKFLPYEDNQDKRRRYILFLQEHAGIVQRGSYENLASHDYEKEADEFAKSARIFKPMTGIMKNRFTSSSSSFSSVSIVDNSSKGGIINIPAKENNTAEEAAKMNMFGSLTRIITTFYPARLLCKRFNVRNPHPDKQLDVSNINDDSKNELVNVSIVENIMREVKGDETYILPEKRQEILNIDDTTNKALEKERPDMDIFISIFGEDKDDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ44</accession>
    <name>M7NQ44_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02329</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874331.1">
        <property type="nucleotide sequence ID" value="XM_007876140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ44"/>
    <dbReference type="STRING" id="1069680.M7NQ44"/>
    <dbReference type="GeneID" id="19896022"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02329"/>
    <dbReference type="eggNOG" id="KOG3218">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058320_0_0_1"/>
    <dbReference type="OMA" id="VRDRGYF"/>
    <dbReference type="OrthoDB" id="248779at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1340.10:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.20:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1340.10">
        <property type="entry name" value="RNA polymerase, Rpb5, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.20">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00025">
        <property type="entry name" value="RNApol_Rpo5_RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014381">
        <property type="entry name" value="Arch_Rpo5/euc_Rpb5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005571">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036710">
        <property type="entry name" value="RNA_pol_Rpb5_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000783">
        <property type="entry name" value="RNA_pol_subH/Rpb5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035913">
        <property type="entry name" value="RPB5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01191">
        <property type="entry name" value="RNA_pol_Rpb5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03871">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000747">
        <property type="entry name" value="RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53036">
        <property type="entry name" value="Eukaryotic RPB5 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55287">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb5 N-terminal" evidence="7">
        <location>
            <begin position="7"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase subunit H/Rpb5 C-terminal" evidence="6">
        <location>
            <begin position="138"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="211" mass="24522" checksum="DB5876AEA6C449E3" modified="2013-05-29" version="1">MNTFSDERDIIKVFRVWKTAHQMVHDRGYLVSQEELDITLEQFKQQYCTINGVDRSTLSFYARSPPGSNKEQIYVAFQREPSIGISAMQDFIHMLQEHGHKIGILIYQTSMTPSANKIIATMAGKFTIEAFQESDLLVNITHHELVPKHIVLTPQEKKELLERYRLKETQLPRIQIADPVARYYGLKRGQTVKIIRRSETSGRYASYRICM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ95</accession>
    <name>M7NQ95_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01029</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872942.1">
        <property type="nucleotide sequence ID" value="XM_007874751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ95"/>
    <dbReference type="STRING" id="1069680.M7NQ95"/>
    <dbReference type="GeneID" id="19894727"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01029"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_378603_0_0_1"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="50"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR10883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="732" mass="81973" checksum="2200B44D2F2F86E6" modified="2013-05-29" version="1">MTAVLRQSPLPPPRTSSLQNQKQGGDYLHASSSLNCKMNMELHETRFGDYILGQTLGEGEFGKVKLGWPRRGLMQLPNGQVRPDVQVAIKLIRKDSINGSRTRLNKIRREVSILRYVCHPNIVKLFDVIETTQYIGIILEYASGGELFDFILVHRYLKDNIASKLFAQLISGVSYLHKKGIVHRDLKLENLLLDRNKNIIVTDFGFANVFDVGDNLNIFHDIDGVSERSFKRGDLMQTSCGSPCYAAPELVIGDGCYVGRKVDVWSCGVILYAMLAGYLPFDDDPNNPDGDNINLLYKYIINTPLTFPEYVSVLARDLLKRLLVPDPKRRASLQDITTHPWLIHHIDLFNISLNPAETSTFNASNEKRHVSSNIIPQSKAPFKLNREKYNGHVDYSCTCSGYLSKGQQASSVSNNYKRHTVHIDCEPHVQNYNHSLLTKEMPYSKYTSVNDNFNDMMSTLNISLSENALSHDTNYNSASTLTTVSESNKTPASIKGPTKVSAISQLNKLPAPPKKPRPTSYQSPVGIFEGSGANLFNSFNTNTRNKQFKRNTIYIPTSNSTSSKPAFLCEKGDLYVSRAPPSLLPIPVVSKNAELSRPPSPLKYTSNVTLGTSMGILPIDDKYVPKKVSNTHKRGSNSISIGAERLFGKIWNGNLNHSLFSLSTDKNYKNVPYVTHMDLLTHNELDLAKLNIKKTSKISKTKKIFTTGSGEKNSTARVMSWFTRKRKNKDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQK4</accession>
    <name>M7NQK4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874330.1">
        <property type="nucleotide sequence ID" value="XM_007876139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQK4"/>
    <dbReference type="STRING" id="1069680.M7NQK4"/>
    <dbReference type="GeneID" id="19896021"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02328"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_11_1"/>
    <dbReference type="OMA" id="IYEYYGM"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05941">
        <property type="entry name" value="MCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF15">
        <property type="entry name" value="AMP BINDING ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="444"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="62071" checksum="A26357104353D446" modified="2013-05-29" version="1">MFFIFSNKKFEKTKYINQIALPKTPIFEKLVKNDKNSISIEFKQNKESYSYFDLIHHILTFKSSLQTIEEEKDLKQKRVGIFVEPGFSYATSILGIWAAGGIAVPICITYPIAEIKYIVEDCSVDIILTSSFLEEKIKNILIYIKKKVHVHVLLKSNLIQQKESYEFLPFDLDRGALILYTSGTTGSPKGVLTTHKNIFTQVISLVEAWKYSSKDRLLHILPLHHIHGIINALICPLYAGGTIEFLEKFNAKDVWSRFLDLKLPQISQFMAVPTIYSKLIHYYTNNGLEISNAELKSRMKKIRLMVSGSAELPISLRKKWHEITGHILLERYGMTETGMILSGGLEFEKRLEGSVGWELPYIKVRLVKIQDEDQEIWVNGDTVFKEYFNKPDATKKAFAYEKDGTRWFKTNDIATKMENGAYIIHGRRNIDIIKSGGYKISALEVQQKMLSLPYIYEVAVIGINDEVWTQRVAALVSLTPDKKELTLNNLRSDLKSMLATYKIPTILKILPNGIPKNHIGKVNKKDLVKEFNYGNIQEWSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQV2</accession>
    <name>M7NQV2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ZW10 C-terminal helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874204.1">
        <property type="nucleotide sequence ID" value="XM_007876013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQV2"/>
    <dbReference type="STRING" id="1069680.M7NQV2"/>
    <dbReference type="GeneID" id="19895913"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02220"/>
    <dbReference type="eggNOG" id="KOG2163">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006571_0_0_1"/>
    <dbReference type="OMA" id="REVQYSQ"/>
    <dbReference type="OrthoDB" id="534815at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046362">
        <property type="entry name" value="Zw10/DSL1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055148">
        <property type="entry name" value="ZW10_C_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205">
        <property type="entry name" value="CENTROMERE/KINETOCHORE PROTEIN ZW10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205:SF0">
        <property type="entry name" value="CENTROMERE_KINETOCHORE PROTEIN ZW10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22766">
        <property type="entry name" value="ZW10_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZW10 C-terminal helical" evidence="2">
        <location>
            <begin position="675"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="813" mass="95773" checksum="A6490296E5BAA7DE" modified="2013-05-29" version="1">MAEISRRKFIDTIVNDESEKINKIINQSILNDMVSLEKLKRSEEPLNVALEKIDVEIKKTRETLSRLILKNETLFLKRFNQKTELYEKITELIANSSVLSEIEISNQEISKTLNDKSENLRELNDSIQVKEALKDTVLKIKFIVSLINKAENFIIQGDLFRVFDTINEAEIECNTIRDEKNVVILSFFREKISKLKSILIERFNDIWDDFVRFEDEFIVKKQLKGPFQKKESLVSFIELSRQFEMFDIHMIDISNYFVSKYFQTFLLNKENFYALDWSENDDEYQLIIKIDTSKKKESVFPSLLILINFIEKAFPSIMLSSLTKHLFPKIQSFLTNDYINNIIPDGIDGLDKFNGILLEGFEFNKEIKQTIWNNYLEIEKWIKQASESWIMKIKSNAIDSVRKVLKLEDPCNIIIERVQNIKSRQVVDDEKVDFVDNNDWDLDWGNEDKEIFDDEKNKVTIEHDTWGLDNDIVDNDSENDHLKDESWGWNDNNYQDIDTKKHRDMKDLENKKSLSDFLEYKSYAISFFPKKIIPIVQKHLSYITELMKPQYANYMMASFFPQLSDSITLILSTFRALVPLHCNQLLISPMLLYNDFIYFSEYLQELYDGSTELHCILEESNIFREAGNFAYFFELQMQKKNIISILERTRGFVNCTDKQQIEICSFALSDLQEMFRVLSKSWGEIFTRETLFESIGRLLEIVVVYIITAIKDIPDISEAESKQLSTLFNQFAQVEDIFTVEKQMFPITPTYVPSWLKFRYLLEILEASMQDLMYLYNSGALVDFEKEEIIDLLKTLFAETPSRAENILKIRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQV7</accession>
    <name>M7NQV7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Meiotic nuclear division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02225</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the MND1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874209.1">
        <property type="nucleotide sequence ID" value="XM_007876018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQV7"/>
    <dbReference type="STRING" id="1069680.M7NQV7"/>
    <dbReference type="GeneID" id="19895918"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02225"/>
    <dbReference type="eggNOG" id="KOG3433">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080628_3_2_1"/>
    <dbReference type="OrthoDB" id="9978204at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120231">
        <property type="term" value="C:DNA recombinase auxiliary factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120230">
        <property type="term" value="F:recombinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010774">
        <property type="term" value="P:meiotic strand invasion involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005647">
        <property type="entry name" value="Mnd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040453">
        <property type="entry name" value="Mnd1_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03962">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026991">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mnd1 HTH" evidence="7">
        <location>
            <begin position="15"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="78"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR026991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="168" mass="19660" checksum="45AAC272BF5A6DF2" modified="2013-05-29" version="1">MSKKGLSLAEKRARLEELFHESKEFFQLKEIEKKGYQEKKIVLQSIKDILQSLVDDGIVKMDKIGTSNYFWSFPSEARQSRQLRITTMEKQLETLQAETQTLQDKINEETSQRKDSQLRTSLLKNVAEKEKKHTEILAKLERYRDSDPAIIEAKGIYIIIQNIDIIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NR36</accession>
    <name>M7NR36_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00776</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872679.1">
        <property type="nucleotide sequence ID" value="XM_007874488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NR36"/>
    <dbReference type="STRING" id="1069680.M7NR36"/>
    <dbReference type="GeneID" id="19894474"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00776"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023312_0_1_1"/>
    <dbReference type="OMA" id="FAWQGMQ"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016278">
        <property type="entry name" value="DUSP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000941">
        <property type="entry name" value="DUSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="64"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="5">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000941-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR11183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="286" mass="33545" checksum="81FF570E73E90873" modified="2013-05-29" version="1">MILYEVYSNLYIGCFKGFLHEIKEKTHKITHLIGLISFNNRTKLLGYRSLFFEINDESDENIIQYFPESIRFIEECFNMDSKNKMLIFCQAGISRSTTIVGAYLMQRLKISKEEAILYIKKVHPDAEPNPGFMEQLQLFHDCNYVLNQEMKLYRQWLLKHKIYSSLQDKKVPEISLYSQDESIQNGQIHLRCKKCRLVLANSNYIIDHQPQQSFIQCTHFFLEPLAWMKNELDNGNIEGKLNCPKCSSRIGKYAWQGMSCSCKKWVTPALSIQKSKIDVIKKELTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M7NR73</accession>
    <name>M7NR73_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_02199</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874183.1">
        <property type="nucleotide sequence ID" value="XM_007875992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NR73"/>
    <dbReference type="STRING" id="1069680.M7NR73"/>
    <dbReference type="GeneID" id="19895892"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02199"/>
    <dbReference type="eggNOG" id="KOG1342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007727_7_4_1"/>
    <dbReference type="OMA" id="GKIMEWY"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070211">
        <property type="term" value="C:Snt2C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061188">
        <property type="term" value="P:negative regulation of rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045128">
        <property type="term" value="P:negative regulation of reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061186">
        <property type="term" value="P:negative regulation of silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016479">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044804">
        <property type="term" value="P:nucleophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034503">
        <property type="term" value="P:protein localization to nucleolar rDNA repeats"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070550">
        <property type="term" value="P:rDNA chromatin condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030174">
        <property type="term" value="P:regulation of DNA-templated DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="11">
        <location>
            <begin position="38"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="388"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR09616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="526" mass="59515" checksum="85E0B87D48A0A707" modified="2013-05-29" version="1">MASQAKILDPIALNGQSPRRVAYFYDSDVGNYAYGAGHPMKPHRIRMTHSLIMNYGLYKKMEIYRAKPATKHEMCQFHSDDYIEFLSRVTPENMDNYIKEQGKFNVGDDCPVFEGLFEFCAISGGGSMEGAARLNRGKCDIALNWAGGLHHAKKSEASGFCYVNDIVLGIIELLRYYPRVLYIDIDVHHGDGVEEAFYTTDRVMTCSFHKYGEYFPGTGELRDIGVGKGKYYSVNFPLRDGIDDESYAFVFEPVVSACMEWYRPGAVVLQCGADSLAGDRLGCFNLSMKGHAACVKFVKKFGLPTLVLGGGGYTMRNVSRTWTYETGLINDVEIGPEMPFNDYYEYYGPTYDLNVPASNMQNMNSKEYLEKIKTEVLKNLSRTKFAPSVQMQNVPLDRNNDSEEEEEDPDKRKNILWNKNPQRSDEFSDSDDEGDGNRRDFTFFDFVKNNSDFQDSSKVGLNAEELENNSKHNDFNIKSEYNAGVVEVKNEDIELKFELNAEDSTVFNSVSSPISTMDNVNNNMAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M7NR82</accession>
    <name>M7NR82_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein heavy chain, cytoplasmic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dynein heavy chain, cytosolic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PNEG_02210</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874193.1">
        <property type="nucleotide sequence ID" value="XM_007876002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NR82"/>
    <dbReference type="GeneID" id="19895903"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02210"/>
    <dbReference type="eggNOG" id="KOG3595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000038_7_0_1"/>
    <dbReference type="OMA" id="NERQMTR"/>
    <dbReference type="OrthoDB" id="447173at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Region D6 of dynein motor"/>
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        <property type="entry name" value="AAA_9"/>
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    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
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    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
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    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
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    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
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        <property type="entry name" value="Dynein_AAA5_ext"/>
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        <property type="entry name" value="Dynein_HC_stalk"/>
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        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
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        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
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        <property type="entry name" value="Dynein_heavy_linker"/>
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        <property type="entry name" value="Dynein_heavy_tail"/>
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    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF13">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
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    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="1920"/>
            <end position="2058"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2548"/>
            <end position="2701"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2889"/>
            <end position="3055"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="3148"/>
            <end position="3218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="3381"/>
            <end position="3457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMR09626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="4295" mass="501534" checksum="18677B39587CA6E4" modified="2013-05-29" version="1">[encoded data, 4295 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRE3</accession>
    <name>M7NRE3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dihydroorotase</fullName>
            <ecNumber evidence="3">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01878</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873852.1">
        <property type="nucleotide sequence ID" value="XM_007875661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRE3"/>
    <dbReference type="STRING" id="1069680.M7NRE3"/>
    <dbReference type="GeneID" id="19895572"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01878"/>
    <dbReference type="eggNOG" id="KOG2902">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041558_0_0_1"/>
    <dbReference type="OMA" id="TLHHISM"/>
    <dbReference type="OrthoDB" id="1670005at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004721">
        <property type="entry name" value="DHOdimr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00856">
        <property type="entry name" value="pyrC_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137:SF1">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="8">
        <location>
            <begin position="13"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="274" mass="30340" checksum="64BBBDF9F5C50B87" modified="2013-05-29" version="1">MSLYLCQEITPSMIEEAKAAGIVGIKMYPKGVTTHSEFGVEDYESYYPIFSAMEKHGLVLNIHGEISSSMSEDVTVLTAEQAFLPILYKLHELFPKLKIVLEHCTTKEAIEAIEKCGDNVSGTITAHHLFLTVDDWAGDPYAYCKPVAKLPSDRKALLNAATSGNKKFFLGSDSAPHPRTLKIGTKKIAAGIFTQPYLISYLAEAFDRVGKLDKLENFACIFGREFYNVKDIGIDKKIILTRKPLQIASELGSEDAILVPFLGGSVLNWTITWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRF6</accession>
    <name>M7NRF6_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein S6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874013.1">
        <property type="nucleotide sequence ID" value="XM_007875822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRF6"/>
    <dbReference type="STRING" id="1069680.M7NRF6"/>
    <dbReference type="GeneID" id="19895727"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02033"/>
    <dbReference type="eggNOG" id="KOG4708">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126331_2_1_1"/>
    <dbReference type="OMA" id="HQIGDYW"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15465">
        <property type="entry name" value="bS6_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_bS6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="Ribosomal protein S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="109" mass="12571" checksum="6849C5E063202AD0" modified="2013-05-29" version="1">MVLYELLCITKADLKIKSLRELAKTSGSTIINKGGIIRGFEDWGNLILPKKKKKHQQIHHEGRHWTMLFDSNPQAQLEINKILRLDPRVINYSIIKLGSKLHEISEKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRS8</accession>
    <name>M7NRS8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01746</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873710.1">
        <property type="nucleotide sequence ID" value="XM_007875519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRS8"/>
    <dbReference type="STRING" id="1069680.M7NRS8"/>
    <dbReference type="GeneID" id="19895440"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01746"/>
    <dbReference type="eggNOG" id="KOG0710">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046737_8_3_1"/>
    <dbReference type="OMA" id="PIWQPKF"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="35"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="183" mass="21066" checksum="E5F7544BE8B7B1F3" modified="2013-05-29" version="1">MIFPRMLETTFFPTDLGRFIHSTFDEPLFYFKENLADRTLSPRIDMSESAKEYCVEVELPGLKKEEIIIEFVDQKTIVVQGHIERLNCNKSNGDGPIVEEIVDEEPKSKSKSTSLKVCEKNVLKKSPRVTYWYKERAFGEFSRKICFPTNVDRDHVKATLENGILKITVPKSACSVTRRIAID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRW2</accession>
    <name>M7NRW2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear control of ATPase protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02017</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873997.1">
        <property type="nucleotide sequence ID" value="XM_007875806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRW2"/>
    <dbReference type="STRING" id="1069680.M7NRW2"/>
    <dbReference type="GeneID" id="19895711"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02017"/>
    <dbReference type="eggNOG" id="ENOG502QTT6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008227_1_0_1"/>
    <dbReference type="OMA" id="YHEFHED"/>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013946">
        <property type="entry name" value="NCA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234:SF1">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08637">
        <property type="entry name" value="NCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="65786" checksum="DFC0E79EFB1CBA10" modified="2013-05-29" version="1">MESTVDTLIKDLRYQLNFIKIDNLELKEIKQDLDVFKKKISITRINELLKKISKEKENDINWLILSFCTINVYEHFLKYLFKHILPISEGLIYWNRIASSPWLSMIYLLQTLPLRIFLFIRQNYIFSQNNLSFQVFRNIKKHIQNRSLFHKIAFPNIFIHERSQLLPIYGLIRHEIIEKQKYLLKLQKQKAIAIGHLMNIDFNLEKNWKEITVKRIQLLSNSISQISEKKPETFFPNSLSSTATFLNDIINNITQIQNMSSLYIRNHGRPSIFIRYWLPVLIFSFSASSIFQIVLSKKKALSEWLKEFIKMSISFWKNWVISPIEKIVSIIHHDRQSEIALMSKKSLETDLQSLERMVVDFAIDNPAYSRGKSMQTLRENVRLGDLTSTLLAYEKHMKTPIKSIVTGKLIRSLLIQIQKTKVDVEVVINGIDKLLKSQELVFGFVGVMPGLTVCYLILRYFFGIWNKRNIAKKRLKTKILPSLRNIERILLMSNDQDTLSYYNQGLLLCEVQILRSYAYTLPANVHTSYLQDLHDLENTKTLKITNQLRVVDRILRLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7NS39</accession>
    <name>M7NS39_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Bms1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_01690</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. BMS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873653.1">
        <property type="nucleotide sequence ID" value="XM_007875462.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NS39"/>
    <dbReference type="STRING" id="1069680.M7NS39"/>
    <dbReference type="GeneID" id="19895384"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01690"/>
    <dbReference type="eggNOG" id="KOG1951">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002486_0_0_1"/>
    <dbReference type="OMA" id="KLHVPMV"/>
    <dbReference type="OrthoDB" id="10260897at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000232">
        <property type="term" value="P:regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01882">
        <property type="entry name" value="BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000105">
        <property type="entry name" value="BMS1 ribosome biogenesis factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037875">
        <property type="entry name" value="Bms1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="13">
        <location>
            <begin position="74"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="396"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="482"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1075"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="401"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="420"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="489"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR09931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1151" mass="133105" checksum="A59F1341EE29B2F7" modified="2013-05-29" version="1">MDSEDKKKHRPRQSGSKVTKKKAKKQEKSSQQNNAKAFISRSWRKSNVLERRSADVIQKKLHIPMVDRTPDALPPIIVAVVGPPGTGKTTLIKSLVRKFSKHTLNEINGPITCVSGKKRRLTFIECPNDLNSMIDIAKVSDLILLLIDGNFGFEMETMEFLNILIPHGFPKIMGILTHLDLFKKPEALRTAKKRLKRRFWTEIYQGAKLFYLSGVINGRYPDREILNLARFISVIKFRPLIWKNSHPYLLVDRMEDITDPQKIHEKPFCDRVVVLYGYLKGTSFPATNGRIHIPGVGDLSVSEVSSLPDPCPLVEKTRTLGEKQKLIYAPMSDVGGVMFDKDAVYIDIPTNDFSKKDIEECGIGEKMIIELQKSNHDLGEDFSKNDLQIFHNGKRIKYDSSDNNTGRKQMRSPNIINDDYDSKNFEDNDMKDMDEFDSEEYKGPDDNLESNADSDSSDSSEVKDEMLQNMDFELNDVEFNEDNASRKTNGNSLSDSSGLKSSTENSDNEYFGISSTWKENIERISENMFNLGKKTPDLGDLIYIKMEYTPKQVVDIWEGVALPNSNGEDPVLKNVKLIDNSDDLLRVIRFDKDENQDFFERSKPPINISALKFWEKEENLEALKTRFITGSLLNNNISDLQPDIDEDLYGDFTDLENDQENKNELVFSDNKMNEDLQKEREINLKKKELAIRFKEEDNTKDSDSDEKLDWYQQQKLKISKQLEINRQEYQGLELSDRVRIEGYRAGLYIRLLVSNMPCEFVKNFDPKFPIVVGGLLSSEEQFGFLKVRIKKHRWHKKILKTNDPLVFSIGWRRFQSLPIYYTSDSRVRNRMLKYTPEHMHCFAAFYGPLTNPNTGFVAVQSVSADSIKSGIFRIAATGVILDNDQSTEIVKKLKLVGVPYKIYKNTAFIKDMFNSSLEVAKFEGASIRTVSGIRGQIKKALTKPEGYCRCAFEDKILMSDIVFLRAWYPIKPKKYYNPVTSLLMEDKSSWKGMRLIGEIRKDLNIKTPLPINSQYRKIERPARHFNPLRVPKALAASLPYASKQRNMKPQRKKTYLQKRAVILNPEERKIRDLMHKLLTLRNEKIKKRKEKQEERRESFKKKMAKEDLIKKEKEKARGKLIFKKEEIKRLKTEKKGFNFKKKKDMSNDMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSC8</accession>
    <name>M7NSC8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873748.1">
        <property type="nucleotide sequence ID" value="XM_007875557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSC8"/>
    <dbReference type="STRING" id="1069680.M7NSC8"/>
    <dbReference type="GeneID" id="19895474"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01780"/>
    <dbReference type="eggNOG" id="KOG4299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_430270_0_0_1"/>
    <dbReference type="OMA" id="CHARDTS"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15535">
        <property type="entry name" value="PHD1_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15534">
        <property type="entry name" value="PHD2_PHF12_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052819">
        <property type="entry name" value="Chromatin_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="259"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="388"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="636" mass="74136" checksum="045BAD539E4F93A8" modified="2013-05-29" version="1">MPELIDKIVIKSRKSEGNRLKKKELEQEKRIKNTLEEKQIERGSLDDYIYNDPQKGRLTMDEYEMLNWRKRRHTERTKSRSKKTRFSENNEYKQEKNTGGKVRQVRLKVGVNRSPASSYSTFLSLKSSSKVPRTENPLFKPLHLFSNTKGILQSSIRSTSDLEQKLLQKKDTFNKQKNKETLHLSSQQKPTLLRLSSSAIPVKRRRVGRPKKVKFSPIKNFMKKTKLDIGISGIYTRNTNHMSFQMQPSSQEDPTKYNEDFCSACKRYGRFLCCESCPRSFHFSCIEPPIDEDDLPQDAWHCTLCRTKRCPPPKQPRGLFAFLMEYIIRNNPKEFSLPLSIREYFEGVSTGPDGEYQDLVEHRNQKCGRQKIFEERDPFQLEDKDGNPILCYKCSENAMNGKAIVSCDHCSLHWHIDCIDPPMSGIPAASRKWMCPNHAYHVTPKIRQPKKSKILDVCLKRGFKNNGNIEIDNTEEELLEKKEKYSFDDTYIINNIRYRLPESGVKLDFLDKVRTLRKSQLSQKSQINNNKIQSNTLKEILPDTLGPLEREIIKDLIQLRLVEVTPQDHKNLTSLITIAQMELDAFKNYEKNENSEKDNIKTEHKISDEEHAQVLTIKKLIKIKGYSALVEFLTTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSJ7</accession>
    <name>M7NSJ7_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chaperone DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00157</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872018.1">
        <property type="nucleotide sequence ID" value="XM_007873827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSJ7"/>
    <dbReference type="STRING" id="1069680.M7NSJ7"/>
    <dbReference type="GeneID" id="19893855"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00157"/>
    <dbReference type="eggNOG" id="KOG0712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_10_0_1"/>
    <dbReference type="OMA" id="RVCPTCV"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140602">
        <property type="term" value="C:nucleolar peripheral inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140453">
        <property type="term" value="C:protein aggregate center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006458">
        <property type="term" value="P:'de novo' protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140455">
        <property type="term" value="P:cytoplasm protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140454">
        <property type="term" value="P:protein aggregate center assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035719">
        <property type="term" value="P:tRNA import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000048">
        <property type="entry name" value="DnaJ family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000003">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="129"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="129"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="382"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="414" mass="45908" checksum="3F1F6B17C3CCB8D2" modified="2013-05-29" version="1">MVKDTKYYDILEVNPQAGENDLKKAYRKLALKYHPDKNPAAGDKFKEISHAYEVLSDPQKREIYDRYGEEGLLGDGSGGMGGMNAEDIFSQFFGGSMFGGGSSRGNTGPRKGKDLVHSLKVSLEDLYKGKTSKLALQKNIMCPKCDGRGGREGAVKQCSTCNGTGHKTVTRQMGPMIQRFQTICPECNGEGEQIRDKDRCKECKGKKTINERKVLSVYIDRGMKEGQKIVFNGEGDQGPNIIPGDVIFVLEQKEHHSFKRRDDDLYTVIKIDLITSLAGGKAFLQHLDDRYLEINILPGECIKPGEIKVVEGQGMPSYRHHDHGNLYIRFEVEFPRPHFISDPSNFSILEKILPPRTEQRIPSNAITEEVIINDVDPMQEARAEGAAKGGRGANGMAEDCDDDNAPPGVSCAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSL6</accession>
    <name>M7NSL6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873330.1">
        <property type="nucleotide sequence ID" value="XM_007875139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSL6"/>
    <dbReference type="STRING" id="1069680.M7NSL6"/>
    <dbReference type="GeneID" id="19895092"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01395"/>
    <dbReference type="eggNOG" id="KOG3901">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076665_4_0_1"/>
    <dbReference type="OMA" id="CERAMNV"/>
    <dbReference type="OrthoDB" id="10266074at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07978">
        <property type="entry name" value="HFD_TAF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF5">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="110" mass="12834" checksum="A593EFD85EA61AF3" modified="2013-05-29" version="1">MTSNQDSFTKGKTIKRQHLFIKDLKSLMYAFGDNKQPALDSVRILEDIVIDYINEMCLEAARIAGTRNKLKVDDFKFVLRNDPRKLGRVEELLTLQRVITEARKQFDDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSP3</accession>
    <name>M7NSP3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Membrane insertase YidC/Oxa/ALB C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_01536</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873481.1">
        <property type="nucleotide sequence ID" value="XM_007875290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSP3"/>
    <dbReference type="STRING" id="1069680.M7NSP3"/>
    <dbReference type="GeneID" id="19895231"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01536"/>
    <dbReference type="eggNOG" id="KOG1239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_597326_0_0_1"/>
    <dbReference type="OMA" id="FIEVCLN"/>
    <dbReference type="OrthoDB" id="2148490at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20069">
        <property type="entry name" value="5TM_Oxa1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="YidC/Oxa/ALB_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF66">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEIN OXA1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane insertase YidC/Oxa/ALB C-terminal" evidence="12">
        <location>
            <begin position="148"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="425"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="430"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR10272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="458" mass="53629" checksum="0E35F1BF7BBBEEC2" modified="2013-05-29" version="1">MTFFKKIPILNKIERYSFFFPVQLTNFRRFSTKVFQKTLYSFERNETLKYDKIIIYYRGYNFLKDKSMSFGDFFLFKHRFSTTSKLLSEHPERTTDLISENTESIIETPLEVIHRIGDLKAMGFCHWTPVGFLQQSLEYIYVFTGLPWWASIATLTVIIRFSMIPFLIGMIRNLSTLALIHPQVQNHMKALKEAQLEGDMIEQAKRTQSIQKLFKEYQVNPLKSLAMPFIQMPVFVSFYLACSRMASLPVPGLKHGGLGWFTDLSASDPYFILPFLNSSLMFINLELGSEVGSSASTNVNMKMRNFFRIIILLTPLFTINFQSAIFCYWITSNIFSLGQGFMLRQSSVRHLLNLPPLKPKIEYDKLDNSKNSEGFKSNFIAMVEGIKNTHRQIIEIGQNVYKKPSESNKYPRPIDKTLEAYMLRKKNKYKEKQERQEKQEKQEKQEKQEKQEKQEKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSR7</accession>
    <name>M7NSR7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Receptor L-domain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01435</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873375.1">
        <property type="nucleotide sequence ID" value="XM_007875184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSR7"/>
    <dbReference type="STRING" id="1069680.M7NSR7"/>
    <dbReference type="GeneID" id="19895132"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01435"/>
    <dbReference type="eggNOG" id="ENOG502QUZC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035846_0_0_1"/>
    <dbReference type="OMA" id="WANNITF"/>
    <dbReference type="OrthoDB" id="536881at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051648">
        <property type="entry name" value="CWI-Assembly_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018:SF3">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082261" description="Receptor L-domain domain-containing protein" evidence="7">
        <location>
            <begin position="19"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="43167" checksum="AB51C433C08F290A" modified="2013-05-29" version="1">MLMELLILWFYIISFVLAEKCDEDINVKSQTDLDRISECTVFEGSIYVTSSIPLIDLGNLEHILGDLVIYENDDILLFKAFNLVSVQGKLVFKKLTALEKIELPALSSADTMILFQCAQLQTLNLNTGISRLNHITVSDTSLRNISGFLMKSLISLNINNNNYLSTFNMSNLVTIGDKFSFMQNGLVQNNYGIPISLPSLESSGGLFLQSVSSVELEQLKNITGDFGLSLSTLSNLTLESLSFIQGSLSIYNNTVLTSLEFPNLISIGGTFLISDNPNLHVISGFDKVRYIGGSIHWTGFLKSISLSSITDIKGTVKILSSTHISCPAFTKSRAIIQGANPVCKSSISSDSGGASSNRKNGSYSSKKNGFMFIGGTYFFTAFQILCTIIILHSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSU6</accession>
    <name>M7NSU6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WD repeat-containing protein 44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01595</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873552.1">
        <property type="nucleotide sequence ID" value="XM_007875361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSU6"/>
    <dbReference type="STRING" id="1069680.M7NSU6"/>
    <dbReference type="GeneID" id="19895290"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01595"/>
    <dbReference type="eggNOG" id="KOG0283">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004759_4_1_1"/>
    <dbReference type="OMA" id="CHIKEES"/>
    <dbReference type="OrthoDB" id="1932312at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040324">
        <property type="entry name" value="WDR44/Dgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221">
        <property type="entry name" value="WD REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="236"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="276"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="430"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="598" mass="68762" checksum="7638CE78F2F74A13" modified="2013-05-29" version="1">MDPISLHILTSKVNLVNDIKKKRKKVIAYSDFSLKKSCNLQDDVIFHGENFQNKKNVFSFLFKNNKDSKKISKNYQSCSQKTEGFPTKTSIQLKKLNSLRSSLFLKYIKVKTNHKSKHNYHKLFFAQELYSPSSLKSPVLRESLSFSEFISSEVPIKIPCHKSGAIWAMKFSKDGKYLATGGQDMILRVWMVIGAKDSFDNNKKDRRPKTISVDEDYSTYKELPAPVFFPDPIHEYVGHKLDVLDLSWSKNNFLLSSSMDKTVRLWHVSRKECLCCFEHNDFVTSIAFHPLDDRYFLSGSLDCKLRFWNIKEKNILFWNELPELITAVAFSPDGRMAIAGSFNGLCMFYETKGLRYHTQIHIKSSKGKNSKGSKITGIEAISNVSDNTGDTKLLITSNDSRIRIYNMRDKSLEFKLKGNQNTCGQIRATFSDDAKHVICGSEDKQVYIWKLDNESIVKKNEQSLQHFEVDSNIITVAIFAPIKSKDLLVASGDPIYSSCMNFRRPSNYHNNNISIVSKCQFENFFINKPINENLGNLNENSEHNHGDIIICADYSGKIKVFRYDCASIYREIDTISEKSIKKYKFFNLFKKNCIQISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7NT00</accession>
    <name>M7NT00_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Heat shock protein 78, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01122</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Homohexamer, forming a ring with a central pore.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873037.1">
        <property type="nucleotide sequence ID" value="XM_007874846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NT00"/>
    <dbReference type="STRING" id="1069680.M7NT00"/>
    <dbReference type="GeneID" id="19894819"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01122"/>
    <dbReference type="eggNOG" id="KOG1051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_0_1"/>
    <dbReference type="OMA" id="VSKMMQG"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF176">
        <property type="entry name" value="HEAT SHOCK PROTEIN 78, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="106"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="504"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="10">
        <location>
            <begin position="675"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="320"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR10407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="770" mass="87395" checksum="4EBB7CA7102C200B" modified="2013-05-29" version="1">MRIKKSYLRKIFFRQLLINLDSNSYIRYKKILLPFKYKNIYLLNTRQYSQGINSFRLNPAQEKGSGSFLKEYGTNLTELAKLGKLDPVIGRGEEIRRTIQILSRRIKNNPALVGPAGVGKTAIIEGLAQHIIKKEVPESMKKKSVISLDLGSLISGSKYRGEFEERLKGVLKDIENANREIILFIDELHILFGLGKAEGSVDASNLLKPALARGQLQCCGATTIEEYRKYIEKDAPLARRFQPVYINEPTVSDTISILRGLKEKYEVHHGVRITDAALVTAAVYSNRYITDRFLPDKAIDLVDEAASSLRLQQESKPDAIQELDKIIMTHQIELESLRKESDVISIERREKLEKDLKKKQEEVSVLNEIWIKEKNELLSIKTAQEKLDRARTDLEHAQREGNYARASELQYSIIPELQKKVPKEGDLDKTNSLLHDSVTSEDIALIVSKATSIPTSSLMRGEKDKLMTMEDSLRKKIRGQDQALKVVANAVRLSRAGLQDEKRPLSSFLFLGPTGVGKTALCKALAEFLFDSENSMIRFDMSEFQEKHSISRLIGSPPGYIGYEESGELTEAVRRKPYSVILFDELEKAHRDISNLLLQVLDEGSLKDSQGRKINFKSTLIIATSNLGSDILINDQSPEGTISEKTKRAVMEIVESTYPPEFLNRITAIHCFNKLGRKCLRDIVNIRLQEIQERLNDRKIVLNVDEDSKEWLSEKGYSLTYGARPLNRFIEEKILIPMSSLLIQGKIRSNETIFVKLNKNTSELEVCSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTE2</accession>
    <name>M7NTE2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ras-related protein Rab7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_01604</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873561.1">
        <property type="nucleotide sequence ID" value="XM_007875370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTE2"/>
    <dbReference type="STRING" id="1069680.M7NTE2"/>
    <dbReference type="GeneID" id="19895299"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01604"/>
    <dbReference type="eggNOG" id="KOG0394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_10_6_1"/>
    <dbReference type="OMA" id="TSWKDEF"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01862">
        <property type="entry name" value="Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000086">
        <property type="entry name" value="Ras-related small GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR10351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="23067" checksum="6C2F059F66869969" modified="2013-05-29" version="1">MSSRKKVLLKVIILGDSGAGKTSLLNQYVNKKFSNQYKATIGADFLTKEVMVDDRIVTMQLWDTAGQERFQSLGVAFYRGADCCVLVFDLGNSKSFEALDSWRDEFFIQASPRDPSCFPFVCIGNKCDIEESKRMVPRKRALSFCQSKGNIPYFETSAKECTNIDEAFLLIARIALSMENEDEYVSEFPDPIQINLDSEKPGCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTL3</accession>
    <name>M7NTL3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycogen synthase kinase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_01156</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Protein kinase that acts downstream of the MPS1 MAPK cascade as a highly conservative signal modulator that dictates growth, conidiation and pathogenicity. Phosphorylates HAT1 at 'Ser-8' to block its translocation from the nucleus to the cytoplasm where HAT1 positively regulates appressorium development and pathogenicity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873071.1">
        <property type="nucleotide sequence ID" value="XM_007874880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTL3"/>
    <dbReference type="STRING" id="1069680.M7NTL3"/>
    <dbReference type="GeneID" id="19894853"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01156"/>
    <dbReference type="eggNOG" id="KOG0658">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MKTTMPM"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051984">
        <property type="term" value="P:positive regulation of chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905561">
        <property type="term" value="P:positive regulation of kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000009">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000082">
        <property type="entry name" value="Shaggy-related protein kinase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0309">Germination</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="46"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR10441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="409" mass="47113" checksum="3E5B60BF97FDB463" modified="2013-05-29" version="1">MNILCKVCVNLIMCEGLQGLTFNPFKIIKQENVHYPRDGKVRELNYTSCKIVGSGSFGVVFQTRLVDTNEDAAIKRVLQDKRFKNRELQIMRLIRHPNIVDLKAFFYSNGERKDEIYLNLVLEYIPETVYRVSRNYAKKKQTMPLFDIKIYIYQLFRSLAYIHSQDICHRDIKPQNLLLNPAIGVLKLCDFGSAKVLVAGKPNVSYICSRYYRAPELIFGATNYTTKIDIWSTGCVLAELMLGQPIFPGESGIDQLVEIIKVLGTPTREQIKTMNPNYMEHKFPQIKSRPFNRIFRRETPSDAIDLVSHLLEYTPGSRFSAIEALVHPFFDELRDPNISLPDPSDDDDGSMVIRKLPPLFDFTEHELSIRPDLIEKLVPPHVVPELNARGIDIYNFQPISLEKTRIKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NU36</accession>
    <name>M7NU36_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the rtf2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872842.1">
        <property type="nucleotide sequence ID" value="XM_007874651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NU36"/>
    <dbReference type="STRING" id="1069680.M7NU36"/>
    <dbReference type="GeneID" id="19894628"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00930"/>
    <dbReference type="eggNOG" id="KOG3113">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048955_2_1_1"/>
    <dbReference type="OMA" id="EFRWLHC"/>
    <dbReference type="OrthoDB" id="247013at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006274">
        <property type="term" value="P:DNA replication termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16653">
        <property type="entry name" value="RING-like_Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006735">
        <property type="entry name" value="Rtf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027799">
        <property type="entry name" value="Rtf2_RING-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775">
        <property type="entry name" value="PROTEIN C20ORF43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775:SF0">
        <property type="entry name" value="REPLICATION TERMINATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04641">
        <property type="entry name" value="Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="252" mass="28423" checksum="C44966F9476CC2E9" modified="2013-05-29" version="1">MGNDGGSIPKRDDLIKDAKKLENSETNQVTQLLPWFCCSFSKLPLSEPIVSCGLGRLYNKDILLEYLLSFKEKGSYRKIQKEEGLSVKSQSTEYGISHITTLKDVKELKLKANPAYQVNSTLNKKVFHGENQVGRWVCSVTNREINGHAKFVYLVRCGHVFNDQVLINIKSNECLECGIEFTEDDIIPLNPKQDDLPRLKARLQALKAAGLTHTLTPMKQSKKRKQECLGNDLQQTIPSKISIKTTKLSTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUE5</accession>
    <name>M7NUE5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01068</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872979.1">
        <property type="nucleotide sequence ID" value="XM_007874788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUE5"/>
    <dbReference type="STRING" id="1069680.M7NUE5"/>
    <dbReference type="GeneID" id="19894765"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01068"/>
    <dbReference type="eggNOG" id="KOG4206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041869_2_1_1"/>
    <dbReference type="OMA" id="HIVFYDA"/>
    <dbReference type="OrthoDB" id="277802at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030626">
        <property type="term" value="F:U12 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000039">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045164">
        <property type="entry name" value="RBM41/RNPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16105">
        <property type="entry name" value="RNA-BINDING REGION-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16105:SF0">
        <property type="entry name" value="RNA-BINDING REGION-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="129" mass="14481" checksum="081B9B3BFD17FCB9" modified="2013-05-29" version="1">MDTPNVSLYCKNLNDKIKKEDLRQCLYCLFSVYGPVLDIVVLKTKKMRGQAHIVFRDVASATAAMRALQGFSFFEKEMRIEYAKQKSNAIAKLDGTFKIPAPELDDIRMSAVGGGIISGIKRSREDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUQ1</accession>
    <name>M7NUQ1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Trafficking protein particle complex subunit 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00968</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872881.1">
        <property type="nucleotide sequence ID" value="XM_007874690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUQ1"/>
    <dbReference type="STRING" id="1069680.M7NUQ1"/>
    <dbReference type="GeneID" id="19894666"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00968"/>
    <dbReference type="eggNOG" id="KOG1931">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004654_0_0_1"/>
    <dbReference type="OMA" id="YEIHANP"/>
    <dbReference type="OrthoDB" id="10256906at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055504">
        <property type="entry name" value="DUF7076"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055505">
        <property type="entry name" value="DUF7077"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056916">
        <property type="entry name" value="NTS_TR130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045126">
        <property type="entry name" value="TRAPPC10/Trs130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022233">
        <property type="entry name" value="TRAPPC10/Trs130_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056913">
        <property type="entry name" value="TRAPPC10/Trs130_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251">
        <property type="entry name" value="EPILEPSY HOLOPROSENCEPHALY CANDIDATE 1/TMEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23273">
        <property type="entry name" value="DUF7076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23274">
        <property type="entry name" value="DUF7077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24967">
        <property type="entry name" value="NTS_TR130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12584">
        <property type="entry name" value="TRAPPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23036">
        <property type="entry name" value="TRAPPC10_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TRAPPC10/Trs130 N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Trs130 NTS" evidence="8">
        <location>
            <begin position="357"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7076" evidence="6">
        <location>
            <begin position="545"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7077" evidence="7">
        <location>
            <begin position="675"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="TRAPPC10/Trs130 C-terminal" evidence="4">
        <location>
            <begin position="1010"/>
            <end position="1142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1171" mass="136802" checksum="FECBBDC1A78A97DD" modified="2013-05-29" version="1">MVSAKITVTYSDNFNLWLSIYPKLQNHLPLKNIYWKCSNGIVKYIDNLEINIKPYHQINSEGKPHQLPGLLDSPYLNIFLVKCEDIDVYRSHIRSMIRSWYNTVTSKKNQEWLIIYVILQLDPLVVNKNTNSSKFLSIKASVYDKIKADFNTSKRDRCVQLLLGEVDETESWQDLIVKMKEGILSSFNARIIQYKEDIKKMDSQKTFPGWNYCTFFILKEGLAQSYEQMTLIEDSLAQYDELESLFYQTIRDNQLACFENIGGAHSNDDSESILDTSKKPYRMFILQNTISLFDFRIYLFARQCQLLRQLGEYTDILQRGRNFITTMEVILRKNEETLVPWFIESWIWSSVHNLVNITEEISRDKRLSALRGELLFLARLQLDKIGAAFGHIPNNLLFPDKFVMVSENDTRIHLEESEHITNMQLIRMIDSKEEFLKEYQTLNNYILMEFQQGDKPNSLKRILGDIAAFQHYLKQYKKAADILKNIPEFYSKNGWEKIECSMMQTYASCTFEIGDIEKYMKSCLSLLTFEKYLSQDRTLFYIKEIEKYSKVLGNDILYPLENYFSVQLDEFINQFENKDSYFFELILINKISQDISIQSAGVKMHKESDSQELYFIKENIVIKHGKNVINLISNITSLGNYIIETIEIKIGKICLVKNFLYSGKKFRVALFPRIGSLDVKVMLPSDILLNKQRISIEIDPGKNNVISGYLDIKFSIPNLKIHTSEIKAYLFNKNNHILEDTKQSEEAVPYELEKITENNILPFGNISSNQILSLTIPYFSDNEILEIKAKISVTYFVSTNESYIYISNFTILTTLPLTVDVQNYFKKQCIFSQFLISFNISSLRIISTKLEELDDFFVSPSEISNKTLILPSQSASFIFKIVKKNNFYSDQPLTFNITYHTLEEEIFYIASNMFFHELEINNLCKYYSYIIHIFKKFQQSKINHDEYGLKQIVFTEDHISYWEDELILINSNDRDKIIKIVQKIMHRFENFSVDMELLNCPGKKAKIHIKIPTIHVLHSVDFIIKSDKNINNNIYSILKMTVGEPLYAELRIQQTLGYKIDKDLLEKSEFFYEIHIDNNTWLLSGYKKAGFFVKDDCLQVFSIVLIPLKSGYIMLPTIDITTAATSINFEVDYNYDMKHILVLPAESSVTFHLGSLQHSESLNTKNPIKYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUR4</accession>
    <name>M7NUR4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">CDP-diacylglycerol--inositol 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="5 16">2.7.8.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PNEG_00645</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11580"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16 17">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.11" evidence="5 16"/>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11047.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613315.1">
        <property type="nucleotide sequence ID" value="XM_019757727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUR4"/>
    <dbReference type="STRING" id="1069680.M7NUR4"/>
    <dbReference type="GeneID" id="19894343"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00645"/>
    <dbReference type="eggNOG" id="KOG3240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067602_0_0_1"/>
    <dbReference type="OMA" id="AQTYSEN"/>
    <dbReference type="OrthoDB" id="10251079at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000011">
        <property type="entry name" value="Cdp-diacylglycerol-inositol 3-phosphatidyltransferase pis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014387">
        <property type="entry name" value="CDP_diag_ino_3_P_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000848">
        <property type="entry name" value="CDP_diag_ino_3_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 16" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMR11047.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="237" mass="27066" checksum="FBE4B501EB20F9E5" modified="2016-03-16" version="2">MNRKDAQTHDAFKFYGFEENIFLFLPNLIGYSRILLAAASLKFMPYHPKYCTWLYILSCLLDAFDGMAARWLGQSTKFGAILDMVTDRCTTSCLLCFLSSAYPAYTFTFQFLISIDLASHYMHVFSTLSQGSSSHKKIPDDQSWIVRQYYQNNIILFVFCAANELFFVALYLLSFPPKSPPRLGYVFNIPLSYPVLIGIVSFPICLGKQIINIVQMINAAKALADIDKENRKKEKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUY4</accession>
    <name>M7NUY4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component Sec8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00714</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872614.1">
        <property type="nucleotide sequence ID" value="XM_007874423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUY4"/>
    <dbReference type="STRING" id="1069680.M7NUY4"/>
    <dbReference type="GeneID" id="19894412"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00714"/>
    <dbReference type="eggNOG" id="KOG3691">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004025_0_0_1"/>
    <dbReference type="OMA" id="HMEVRCR"/>
    <dbReference type="OrthoDB" id="272977at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039682">
        <property type="entry name" value="Sec8/EXOC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007191">
        <property type="entry name" value="Sec8_exocyst_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048630">
        <property type="entry name" value="Sec8_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20652">
        <property type="entry name" value="Sec8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04048">
        <property type="entry name" value="Sec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec8 N-terminal" evidence="5">
        <location>
            <begin position="57"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec8 middle helical bundle" evidence="6">
        <location>
            <begin position="308"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1040" mass="122320" checksum="93916E52C80E669D" modified="2013-05-29" version="1">MNYYREYLNIFENNIKENQEDSNERNAENWKQSFKKSINHGDIIRKVEKVESSDEFEDILQYIKEKWDDLTKEECNSVVAALELFDKSSLGKDYNAFKETYQKLQKAFKSTINEHYDEFSCSIGTFGMIMQNITKSLKKTDEINEMILESQERFAFKKNDLYHIYQHSLQLKETLRILKAIDNFRKIPEILEKHISEKRFLTAINLLKEAQQITEKYEMSKIGALVDIKQYISGQKNSLMDIILEELHNHLYLKSPYCDAYWAPYVIGQEELPIPNALKRNKELQSKTYFSYDNENFQQEVKKNNVYNPEVDSEEYIRILTKALHLLDVFPDAIDIIVQRLPVEIYQLIDKTINEVEQRDLNLLQNIFPKQKSLNIIDTDFSEDIMKSEILKDFFWTLYSKLVAVLNGYNIMYIYISDLSSIQSEENEGTTAKLASFNFLNIWKPIKSEIQTLLSNYVVDGSHQIISTSSNFISFNDMFDEKKDIKRIKMFSIHNINENSKDFNDALDDLKNILNSSVVYLMLRGKNVKDKMNPIPYDLKETSFTAHRMLIKSSVFNIEALFKPTWAFLRKCEDTMFLKLRAPDSIIMPFLDEFLSNTFLPQLKDIIQEISNQSILNFDVLQVYENWSVYSTHPVLKSAVSLLALIANLSKILNSISYNNEDYSYILLDILIKYFNKCSLKYKELISLSNHITGNDKTIVKSIKKMSEIWSDNEELKKLLEQFLDNSISLDGFSVMETEKEFSLKNKVPLKYNDIQWDKQVLESLGILYHTLKWIVDMITSNNNIKMNLGNDSHKQTLKSFFKQSNKVVSILRNESDSSEFYMKSESIEKLEVILVNFKELSKTILFNIRIEIRCHVMYYIEKVVRDGNYYLDYSIPKPDLYLLELNTELLEYNEQLDSCLQYQEYSFVFYGLPYLIDNLLVLAAENIKKMNITGSEKMLLNIMILQQNLKNIIRDVENVKFEKSIHFYELLKLGPKNVLKEVKKSSNIFTYDEIKTLLQLQYSEDLVKADKLNRPDITMALKHSLNENLIELNEYLWQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7NV47</accession>
    <name>M7NV47_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S15a-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_00602</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872499.1">
        <property type="nucleotide sequence ID" value="XM_007874308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NV47"/>
    <dbReference type="STRING" id="1069680.M7NV47"/>
    <dbReference type="GeneID" id="19894300"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00602"/>
    <dbReference type="eggNOG" id="KOG1754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098428_1_1_1"/>
    <dbReference type="OMA" id="LPAKNFG"/>
    <dbReference type="OrthoDB" id="10250260at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000001">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047863">
        <property type="entry name" value="Ribosomal_uS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003115">
        <property type="entry name" value="PRK04034.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR11001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="130" mass="14897" checksum="22D5FC49BD1299AA" modified="2013-05-29" version="1">MVRISVLNDCLNGIMNAEKRGKRQVLVRPSSKVILKFLSVMQKHGYIGEFEEIDDHRNGKIVIQLNGRLNKCGVISPRFNVRLSDIENWITRLLPSRQFGFIVLTTSAGIMDHDEARRKHVAGKIIGYFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVP1</accession>
    <name>M7NVP1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">COP9 signalosome complex subunit 3 N-terminal helical repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872702.1">
        <property type="nucleotide sequence ID" value="XM_007874511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVP1"/>
    <dbReference type="STRING" id="1069680.M7NVP1"/>
    <dbReference type="GeneID" id="19894495"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00797"/>
    <dbReference type="eggNOG" id="KOG2582">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_622749_0_0_1"/>
    <dbReference type="OMA" id="NHYHDLV"/>
    <dbReference type="OrthoDB" id="29061at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055089">
        <property type="entry name" value="COP9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF1">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22788">
        <property type="entry name" value="COP9_hel_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COP9 signalosome complex subunit 3 N-terminal helical repeats" evidence="2">
        <location>
            <begin position="45"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR11206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="440" mass="51403" checksum="709829F60D60DA31" modified="2013-05-29" version="1">MNYDKHEFVSAIKKFINVEEIQNILIPYLKSLSIDILVRLEPQDPLKVLDPETYSIGYLYILLARVQISKLESIWEDCVTFLNVFNISLVSTLTPDEFKKILKWICDNANTIDESFLVIDVLKSTLERYPDFAISLTPVRTIFVKQCFITKAYEKARFILDIDVEIFDKNNGITYIDHLLYHFYGALLYIKLKLFDRALQFLRIIISAPTRNTSVIQVNAYKKFVILSLIVNGKMEPIPYITDSIATKTYKVFGKVYNEFSQAYERQDHQEIKDIYLKYRSVFIEDKNNKLIKYAINSLSYHEIYRFKEIYTSISIIDINRKIGPWDDILLDSQDSYNLTEKFISNMIQNGKLNAIITDYNSQRVVNFINTVYDKQIQKETLLKQAKDISILITKLSNLNCSSDLNDMYLAVQSSLSSQHTFYNNQINSLDDFPNIPDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVQ4</accession>
    <name>M7NVQ4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Yos1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00402</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the YOS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872278.1">
        <property type="nucleotide sequence ID" value="XM_007874087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVQ4"/>
    <dbReference type="STRING" id="1069680.M7NVQ4"/>
    <dbReference type="GeneID" id="19894100"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00402"/>
    <dbReference type="eggNOG" id="KOG4779">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152125_0_0_1"/>
    <dbReference type="OMA" id="VQTVMRM"/>
    <dbReference type="OrthoDB" id="15356at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013880">
        <property type="entry name" value="Yos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858:SF0">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08571">
        <property type="entry name" value="Yos1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082492" description="Yos1-like protein" evidence="9">
        <location>
            <begin position="23"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9144" checksum="1E8D0B8BC6BA2A8D" modified="2013-05-29" version="1">MFGLGKLFYVSLLLVNAIAVLSEDRFLAKIGFSGKIEYGFENQSVSSVKFKIVNLISAVRTLMRIPLIIINTLVMTYLLMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVQ9</accession>
    <name>M7NVQ9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872717.1">
        <property type="nucleotide sequence ID" value="XM_007874526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVQ9"/>
    <dbReference type="STRING" id="1069680.M7NVQ9"/>
    <dbReference type="GeneID" id="19894508"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00810"/>
    <dbReference type="eggNOG" id="ENOG502QT50">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079101_1_1_1"/>
    <dbReference type="OMA" id="KIITATW"/>
    <dbReference type="OrthoDB" id="1915122at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040153">
        <property type="entry name" value="Rcf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018:SF3">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="6">
        <location>
            <begin position="80"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="192" mass="21977" checksum="65E13E947DCA56ED" modified="2013-05-29" version="1">MKIFSKEEEEEHYRIVINSGIKSGIIALAISIPCAFILNQKWSKFRQLTLPIKSFFISSIATTALVISSDNASKKYQESKYGPFNPVKSIENSNIQSILFKWCLENKWKIIGGSWVLGMIGSMSFLWKDKYLTKTQKLVQARMYAQAITLIVLLISVGLSIDRDQLFDSNKDFKNTNNNNKKSNQMYIDSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVT6</accession>
    <name>M7NVT6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription elongation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_00440</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TFS-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872318.1">
        <property type="nucleotide sequence ID" value="XM_007874127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVT6"/>
    <dbReference type="STRING" id="1069680.M7NVT6"/>
    <dbReference type="GeneID" id="19894138"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00440"/>
    <dbReference type="eggNOG" id="KOG1105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037637_1_1_1"/>
    <dbReference type="OMA" id="RFVVMTH"/>
    <dbReference type="OrthoDB" id="44867at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001139">
        <property type="term" value="F:RNA polymerase II complex recruiting activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001193">
        <property type="term" value="P:maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045899">
        <property type="term" value="P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13749">
        <property type="entry name" value="Zn-ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.30:FF:000003">
        <property type="entry name" value="Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035100">
        <property type="entry name" value="TF_IIS-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003617">
        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006289">
        <property type="entry name" value="TFSII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01385">
        <property type="entry name" value="TFSII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF0">
        <property type="entry name" value="IP08861P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006704">
        <property type="entry name" value="TF_IIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="10">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="11">
        <location>
            <begin position="125"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS-type" evidence="9">
        <location>
            <begin position="243"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR11417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="284" mass="32575" checksum="5D1B93E9ABCA5323" modified="2013-05-29" version="1">MDISEVRKAHKVLQKAFQEGNQMLIIDILRLLKNKVVVSEALVDTKVGVTIGKLRNYSEKYVADLAKEISKKWRGDLSALKKASLVKNTSEMEKMSVVSSTSNTLEKTRNTVSNCIKTDITGDKVRDNCISLIYNALVCDSDDLNAEILSKAKAIDEFVFNFYSHKTDDSYRQKMRSLLLNLKDKKNPSLRENVINGELSIPRLCTMTSQEMASKERKEEDKKLEEINLFKARGPKPIKAVTDLFQCGKCKQRKVSYYQMQTRRADEPMTTFYECQVCDNRWKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWS6</accession>
    <name>M7NWS6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00166</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BUB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872027.1">
        <property type="nucleotide sequence ID" value="XM_007873836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWS6"/>
    <dbReference type="STRING" id="1069680.M7NWS6"/>
    <dbReference type="GeneID" id="19893864"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00166"/>
    <dbReference type="eggNOG" id="KOG2058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029367_2_0_1"/>
    <dbReference type="OMA" id="CHKSEPQ"/>
    <dbReference type="OrthoDB" id="10263206at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990334">
        <property type="term" value="C:Bfa1-Bub2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035974">
        <property type="term" value="C:meiotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071957">
        <property type="term" value="C:old mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902413">
        <property type="term" value="P:negative regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031030">
        <property type="term" value="P:negative regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000035">
        <property type="entry name" value="Cell cycle arrest protein BUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000026">
        <property type="entry name" value="Mitotic check point protein (Bub2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF263">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="7">
        <location>
            <begin position="50"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR11732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="312" mass="35499" checksum="8BEF451C9D619FA9" modified="2013-05-29" version="1">MDSNQKITEKTFENLMQSFRPKNRSTAEWETSYNQLRRLVLSEGLPSSQEGSSSIRAYVWCIFLGVEPITANSYLALIHKGASSVYNKIRNDTFRTLATDPLFRRKVSEASLIRLLNSFVWYMESHNSSISYIQGMNVLAAPFLYTCKSETEAFSLFTAFISVQCPLYVVSTLEGVHRGIKLFDKCLEIIDIKLYSYLRSKNLQSKVYAFPSILTFSACTPPLSEVIILWDFLLAYGVYLNILCVVAQLLVIRDDILHHPSPIKLLRKFPHLPAKIVIGIAVSLIKKIPAELYELLIRHSWDNSAGTEIDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7NX60</accession>
    <name>M7NX60_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exportin-5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872041.1">
        <property type="nucleotide sequence ID" value="XM_007873850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NX60"/>
    <dbReference type="STRING" id="1069680.M7NX60"/>
    <dbReference type="GeneID" id="19893878"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00180"/>
    <dbReference type="eggNOG" id="KOG2020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IAKRSWG"/>
    <dbReference type="OrthoDB" id="2215036at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042565">
        <property type="term" value="C:RNA nuclear export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045478">
        <property type="entry name" value="Exportin-5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF3">
        <property type="entry name" value="EXPORTIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19273">
        <property type="entry name" value="Exportin-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exportin-5 C-terminal" evidence="1">
        <location>
            <begin position="341"/>
            <end position="1176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1229" mass="144058" checksum="13783925B4D932D9" modified="2013-05-29" version="1">MEKENKVNRLISALSVVYSINTDKAVRNETQKYLDNIKEDPESWKYGIELASFKNVKMDVLRYFGLNLIDQGICCNWEIYTNEDKVYLRNSMINMCYNGVRDGTSEDQNEVHYIKQKISKILFEIIKKDWIFILQDMDMAFKNMFLTSPTARYISLNTLLNLIENAFQSMNDKDMSKMSVFSVGMISILCSSDILKAIYPNGLPYSLKISENNSGWLDIFEKSIKSYFGIINTCFPKINEIEITLILNCLKGCLFWIPAKSILESGILNQLCFILLQGNIEIKMISSDCLHALFIRPLLPDDELLEIVYTFFEPDNLNHLRIITEEIFSQVQYNDYNDFDEKKYSFLKKIVETIVALGTFHILNHRKSNTLLYLNIYLDLVLFTARHPSLIVSSISQSFWIALLKSPLNKENAVISILPRLLDLISNRLIRYENAQIILKDSIEIKFLNHDIETTSEIHIFCENYRRHMVDLVQIIFSMPTKNCLLYAQQHIEKFLKKCPDFMTDQIVFHKKKTLDYHFYDSNYTFIKAVLNGYKILNEKDQHLDNDLKENFLSLLIYWFEKIIHIDIKAPLILSRQIQILVTFLYSLGKKEFLIPVLEKTISALVYRYHDNISDDAIQTIHDLRVKCSHELLKLAMELSDSLWNIYPQLEKIVYEIINEKSCENENIVFITFLLIISQKPNNTQNEKTYYFQLITTKLIDTWNKTKSLFNLSTFNGFFDLLGLQKIMQYIQSKNIYSIQDLNTTYLDLEGKQLINELKEIRKLIWPIQGFRKFVDYHLKIMLLKDNSYDFISELWKPIIEFILPDIFSIIKHIHALCNPDNWNSFVPELQFIISQSISERFWFHGINLTSKDEFYEEISKFKDKVIELIYNLSHFLRKNREHCYMNIGLFSNFGDCFYKIPNLSQNIIESFFTNTKGLSLYVWSSILDFSISPIVTRCPPQYQDCFLKILLPYLFIEIDKKLVFEWSQISEKEFISDNNLNMPSCRDEDLSNEMIKESLLRNLSFVVVKMLTDLLVPSSDKSQFTKNISNLKTSNMLYILKNEDILKSLFPLLLHLIMFHDTRTCNNTIRIFQNIIPILMDDSNIHVCAFITNDLFKACIIAINDTYLASVHSEIIQILTQIYTLAHEKGFQQSKEVLLSISTLNLEKVNELETKLFNVKNSKSKRAIMMDFLSTFGIKPEIDEGKSLKKTTNDINTYKIIKHFKSDMKSSNEDILQQENIGISNLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7P2F6</accession>
    <name>M7P2F6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_03505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875597.1">
        <property type="nucleotide sequence ID" value="XM_007877406.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P2F6"/>
    <dbReference type="STRING" id="1069680.M7P2F6"/>
    <dbReference type="GeneID" id="19897192"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03505"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002863_0_0_1"/>
    <dbReference type="OMA" id="QNQTGHT"/>
    <dbReference type="OrthoDB" id="411857at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050872">
        <property type="entry name" value="PPR_P_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128:SF211">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="850"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="885"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1152" mass="132311" checksum="35BB42514D920583" modified="2013-05-29" version="1">MRRNLMIFGRVRSIRNGSLYLLRNPINGVENNVKPFFFYRLLCLDFLILDKIYTFHVWTRTKEIKSTKIVPTGSSLFCAAPETLSVIPSVSDASSISLLPSKSNIALKYEKKMTKLLQENKYFNIIEVYNEMKSMGIPLTVELYDIIFQSMVKIRQPGVATMIHTLLDTYKSMLEQQLTPNLSIYSTLILALCVREEEVYSQLQTLNNKISRGLPNNLQLQERLNSLRKENNLDMACEIFKASVSVRFQPYSPNVFSELMRICALVGKTDELLMIYQQIVNHNIIPSPRVFISLIRGFSMHKDVKSMVECFNEYKTFAPKMEPHDKYDVYCALIDGYFRSSRSYAAISFFEKLAAQKNAYIPYKVFKIIVFGLSLNGDYLTAKSWIDRMIKDENLPNPTPSCVIPVISSAIKANDLDVAVSLFDYTSSIGSIKPFGRVVFEFIHLCLKHGKNDYANDILNRVSVEGIRPDEMTTQTIALAMISNGNIDSSLQLYKTCLKLNVQHFGSTRYIRRGFTLVGVSLMEELKKRNLLDFKSCLKIITNVYDTAFHIPYPMLLYVLKFYFMEKKMSVEAWRANLKSWDPFILSLSLRVLCFSVKQDRGSYAHKVFPELIRDIISENIAVIPGSAMAVSDTLEILGEKVLSVEWEKYTQKYKPHESFAIDGVPEVSRYQKLRPLSIDLMRDWNQVKNHPRIDFSTSQKILNDSICHNKTDDYSALVHEIHVTYRKGKDITPEAYCRLLERLGKEKKLDLVNDLYKFAKESISKNFTGDTGLCYLGFCLNSMIIAQIYSSQMDAAKKYQRELLELGFSPSASVFATYIINLKNSEPSQDADDAINIYREAKSYNVEFTTYFYNALLSKLCRAEKLHEALEIFSEMKKNNIIPNSITYGTLINACCKIGNEELANDLFVEMENSPRYYARVAPYNIMMQFYVHTKKNRQMALKYYNKLCNQVLAPSPHTYKLLIDCWTVIDPPDIDKALQVLTDMTKNSVSITTRHYGAIIYAKGCILRDLKDARQYFDSITKRNFKPVIPDHTLYQALIDAYVTNYSMKNIPKLLSLMKDNNILLNADIANILIRGWMQEGQIKKAREVFDSLDLQTNSVSKREPSNYIAMIQAYLSVKDITSAKAILKEMRTYSPSLSDISHAESLFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7P2G9</accession>
    <name>M7P2G9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_03515</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875607.1">
        <property type="nucleotide sequence ID" value="XM_007877416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P2G9"/>
    <dbReference type="STRING" id="1069680.M7P2G9"/>
    <dbReference type="GeneID" id="19897202"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03515"/>
    <dbReference type="eggNOG" id="KOG4844">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150777_0_1_1"/>
    <dbReference type="OMA" id="FKEWFPE"/>
    <dbReference type="OrthoDB" id="2257454at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013219">
        <property type="entry name" value="Ribosomal_mS33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08293">
        <property type="entry name" value="MRP-S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="106" mass="12425" checksum="5FE906973A2DD813" modified="2013-05-29" version="1">MEKLPSKKRLLELKSTACRIFGTIFNPKALRMGNRVLLRRFPGSTVSQYYSRFNLPPKVLIRAFPHLNLVDLDESVRKEWVERRKQRGKGPPPKSKFKNESKSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3G3</accession>
    <name>M7P3G3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor ISY1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_03210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ISY1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875273.1">
        <property type="nucleotide sequence ID" value="XM_007877082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P3G3"/>
    <dbReference type="STRING" id="1069680.M7P3G3"/>
    <dbReference type="GeneID" id="19896897"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03210"/>
    <dbReference type="eggNOG" id="KOG3068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043453_2_0_1"/>
    <dbReference type="OMA" id="YHWERRI"/>
    <dbReference type="OrthoDB" id="1739576at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000001">
        <property type="entry name" value="pre-mRNA-splicing factor ISY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="27717" checksum="528F9F5B4E42C7BA" modified="2013-05-29" version="1">MARNSEKAQSMLYRFRASQAAELGIIDTGSQRRPKLITEVNSIQACEKWRGQVVKEIYRKISKIQDPSLTDYQIRDLNDDINKMMREKHMWEIQLRNLQGPNYMRFGPKMVDAEGREIPGHRGYKYFGRAKELPGVKELFDELVPKPPPKPKISETLYKTLNASYFGYQDENDDQLLEFEKQREKESIEAMLNSTEGDPKQDWYSIPDLYIPNQKEIEEFLLQKRKQILLEKYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7P522</accession>
    <name>M7P522_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP citrate synthase</fullName>
            <ecNumber evidence="2">2.3.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ATP-citrate (pro-S-)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Citrate cleavage enzyme subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PNEG_02734</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the formation of cytosolic acetyl-CoA, which is mainly used for the biosynthesis of fatty acids and sterols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA</text>
            <dbReference type="Rhea" id="RHEA:21160"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.3.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Composed of two subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874761.1">
        <property type="nucleotide sequence ID" value="XM_007876570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P522"/>
    <dbReference type="STRING" id="1069680.M7P522"/>
    <dbReference type="GeneID" id="19896425"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02734"/>
    <dbReference type="eggNOG" id="KOG1254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006587_4_1_1"/>
    <dbReference type="OMA" id="HMLRYQA"/>
    <dbReference type="OrthoDB" id="3261737at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06100">
        <property type="entry name" value="CCL_ACL-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000005">
        <property type="entry name" value="ATP-citrate synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000024">
        <property type="entry name" value="Probable ATP-citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118:SF42">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA-binding" evidence="18">
        <location>
            <begin position="23"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00062455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00076189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMR08955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="640" mass="70212" checksum="D910AAA04070CD31" modified="2013-05-29" version="1">MISANDNIYRAPASTCSVDRRELFTFDTRAFVYGMQPKAVQGMLDYDFICGRKTPSVAAIIYTFGGQFVSKMYWGTKETLLPVYQSISVAVSKHSDVDVVVNFASSRSVYSSTMELLEYPQIRTIVIIAEGVPERHSREISYKARTLGVVIIGPATVGGIKAGCFKLGNTGGMMDNIVASKLYRPGSVGYVSKSGGMSNELNNIISQVTDGVYEGIAIGGDRYPGTTFIDHLLRYEADSKCKILLLLGEVGGVEEYSVIEAVKNGTIKKPLIAWCIGTCASMFNVEIQFGHAGALANSALETASAKNRAMREAGIHVPCVFEELPQLLKKIYDNLLAEGVIVKKEEPSVPKIPMDYAWAQELGLIRRPAAFISTISDDRGQELLYAGMPISDVFKEDIGIGGVMSLLWFRRRLPSYASKFFEMVLMLTADHGPAVSAAMNTIITTRAGKDLVSSLVSGLLTIGTRFGGALDSAAEEFTRAMDKGFSPRDFVDSMRKQNKLIPGIGHKVKSRNNPDLRVEIVKEYAKKHFPSTKLLEYALAVETITTSKKDNLILNVDGCVAVCIVDLLRNCGAFTMEEVEDYLKMGVLNGLFVLGRSIGLIGHFLDQKRLRTGLYRHPWDDFLYLGLDKHVPGGNMRALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7P5B8</accession>
    <name>M7P5B8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Structure-specific endonuclease subunit SLX4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02421</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLX4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874427.1">
        <property type="nucleotide sequence ID" value="XM_007876236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P5B8"/>
    <dbReference type="STRING" id="1069680.M7P5B8"/>
    <dbReference type="GeneID" id="19896114"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02421"/>
    <dbReference type="eggNOG" id="ENOG502R79Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_577610_0_0_1"/>
    <dbReference type="OrthoDB" id="5349119at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22999">
        <property type="entry name" value="SAP_SLX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018574">
        <property type="entry name" value="Structure-sp_endonuc_su_Slx4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09494">
        <property type="entry name" value="Slx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="473" mass="54830" checksum="2949AFE9F81B43FC" modified="2013-05-29" version="1">MNKKKEIDGSKKRIKKAEKNKKTEVLSKSVISPNSALDRISNQRLIFNLSTDKINQTNPFFIEKNRELYTSSFIKNIMNKRSKNLWEAVSRDLNGELIGEKNELFSKKSENYQNLIQCLRFSEVSESNMNPDLYISYKHNIKKENIDNCSKPNFIIINSSGSEEELLLNHDSSLVEKYHGKMFKSPIVNSNESGIDSLLLTEDSNLDKNKRISELHTKEIDLKKNLKAEKYASFTEDPLELINTTLDDSLYIESLNENVSLKIMKNDINNDILDEYGLEIKNNSYITKKKDLVEAIETRQISNPEGITMPDFRNYTLVQLQSEVSKYGFKIMHSRKTMIDLLVKCWELSNFSEKKQLIKNDKHNDCGLSQAFGNTLLEQSVTGTLKNCTLLAHLDSNLQSIFLTITKILKSTIGEIYWFKILRYEPIVLEQFIKWLFEQNIVVTLDIVKQYCNIYSICCVHLKTNRGFARKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7P675</accession>
    <name>M7P675_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02307</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874305.1">
        <property type="nucleotide sequence ID" value="XM_007876114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P675"/>
    <dbReference type="STRING" id="1069680.M7P675"/>
    <dbReference type="GeneID" id="19896000"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02307"/>
    <dbReference type="eggNOG" id="KOG0290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013694_1_1_1"/>
    <dbReference type="OMA" id="NEDWMAI"/>
    <dbReference type="OrthoDB" id="1284551at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="264"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR09355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="359" mass="40769" checksum="8BEE523157E0E657" modified="2013-05-29" version="1">MTFYPPFLHTMLWPTYAIDWSLLGGILIGSFVDENQNQIEILKNEEIEEIERKEPSKRLRLKSAGKTMKNLFYPVTKVLWKPYLYERKDKKMFASTGDALRLWSVKEGSYEPIIEEMILEHHQHGTNQIAPTTSFDWNQVTQQLIVTASVDTTCIIWDIEVGEAKSKLIAHDREVFDVSFLAHSADIFVSTGAEGSMRMFDLRSLEHSTILYETGGELGAYSSEPLLRVSANTLDQNLLATFHLDSNIVHILDIRFPGTPVLNIAGHDGNINCVKWAPGCRNICATGGDDCQILIWNTTKESPNPNTLLYKSIRNQEIKQLNNPIFSWNANSEINNLCWSDDAEWIGVCWGKNFQGLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6I4</accession>
    <name>M7P6I4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02079</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874058.1">
        <property type="nucleotide sequence ID" value="XM_007875867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P6I4"/>
    <dbReference type="STRING" id="1069680.M7P6I4"/>
    <dbReference type="GeneID" id="19895773"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02079"/>
    <dbReference type="eggNOG" id="KOG1534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037460_0_0_1"/>
    <dbReference type="OMA" id="LYTHMTV"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000552">
        <property type="entry name" value="GPN-loop GTPase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="2"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="270" mass="30700" checksum="6BACCED65306B044" modified="2013-05-29" version="1">MPRVGVLVMGPAGSGKTTFSHALVSHIQQIGRPAHLINLDPAAETSDLGVTIDIRDLISLQDVMEELEYGPNGGLVYCFDFLMNHLDWLEEELVGFDNDYLVFDMPGQIELYTHIPVLPVLAKYLHLQLNFHLCAAYLLESQFIIDKAKFFAGVMSAMSAMVLLEIPHINIMSKMDLIQSQIRKSDLKRYLNPDPFLLIDEVNSKTNPRYHDLNKAIIQLIDDFHMVSFLPLDIHNEGSIEMILAYIDDCTQWDEDQEPKEPRDSINTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7P787</accession>
    <name>M7P787_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01915</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GCN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873891.1">
        <property type="nucleotide sequence ID" value="XM_007875700.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7P787"/>
    <dbReference type="GeneID" id="19895609"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01915"/>
    <dbReference type="eggNOG" id="KOG1242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000504_2_0_1"/>
    <dbReference type="OMA" id="ANIWEDN"/>
    <dbReference type="OrthoDB" id="5148094at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031571">
        <property type="term" value="P:mitotic G1 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904689">
        <property type="term" value="P:negative regulation of cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022716">
        <property type="entry name" value="Gcn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056810">
        <property type="entry name" value="GNC1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056809">
        <property type="entry name" value="HEAT_GCN1_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF7">
        <property type="entry name" value="STALLED RIBOSOME SENSOR GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12074">
        <property type="entry name" value="Gcn1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24993">
        <property type="entry name" value="GNC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25786">
        <property type="entry name" value="HEAT_GCN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24916">
        <property type="entry name" value="HEAT_GCN1_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="1274"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="1443"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="762"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="2579" mass="294732" checksum="A9C422871C1BB207" modified="2013-05-29" version="1">MVKNQDDSDCETPNEDDDVLERLLFLSGSFKQRNIYLIKKKLEIWIEEVDDIFKFSLILNCLFKAGKFCYNKSIQLCIQYVLLKLYEKDKEQCLVKFIEMLNQETAGMLSRSVSPHPIFILLKWVNKFIINILVNITLIQKYLPELVSNQAILLNLFLSSLVKARAKSSALRSVEGTLRSTIIKTLNENAFLCLNIYIEELIKDTKIGFCMKNTVLFGMIAKITSHSQFNEKSVLMEKKDEIINYYINNIIKSRVLLPNRIITGMNDFFVYFITFEDFKFKIASHLEKALLRTPEITLNGILKELLQSLPLSIKIDEIIYEKFLIPILNSLKSMDSNISENALQTFEGIIQRCNDQDKIHQTMEKIILELNSGFLFSLEHKLLFIRSLACLPKSLELSNSVLSFLSTHIHKKANENISVALIKCFFSHFTYIISTTYEFSDEYIELIKEGFLESMENIRRTWFNEFGNIIWDYRYNPNKQVIYLIKKLLNLLVKIYEDILINPLQSIQSGTIIDGYNNLYFILWEKNYTKSSHKDEKIWLIRSLETIGEYISEEQFEKIGFLWAQASFSLLLSNISHDHSIVSTICSMIKRCYLKSRELVLDIFLSEIWKYIKLLESSHISAYKDLTILDAIFYIINSVSPSDYEFLSQKDKESFEKQLIRTIVLYHHSLLKDKLNWVKLCKRNKMDPSVLVTTHALEFVNTIDYFLRINIENKSNLTLLAIQSSISTLTSLDQVVIVPLFVEVFLKYLSDLELESISEKDISILKDKIDEKIEEKEAIRSKILNLKLRLISGLTVIQGLALAIQKSRDLWYSYAINVLLSKSLLEKGLLIAYESIVQTYLNCAKCTSLKDINTMIGIAMLRILNVDYIHSDFVEEPLKELVMKLLLRLDSLTKQCPIDKISFIYVSPFLIQVIKNNGIGTNNFNESDKQVMLAVNILSFHIDFYKFFISRLEIIQALLNVLYHFPNQFNHAKDCLILLSKVIKDNITKEEIMELIKGSLSSNFQIRNTVLQTIEPLDLSQCDFFYELYLAAHDKNEINSSLSLAIIKKNSFLISRDAKDILINYLCNDQYYIRECASKAISSYVKNYIQDVEEVILILVNLYEEKSKLQSLEYDEYGIPISRTLNRRDAWETRSAIASSFFYLIPYFTLTIVPFFLEFLLGMPNKHVPLKDNSPEVREKMLKNGLSIISYYGDFHVENLFKILDNHLTSSDGLLESYIDEGVIILYAAITSHLKMDDRRVPIAIGKLMNMLRSPSENIQIAIAESFSSLIKFSLEKVPNYIERLKEELFTSGKYAERKGAAYGLAGVIKGGGIELLEKYEIIETLKNAITNKKDHKYRQGALFAIESFSQILEQAFESYIIEMIPYLLTTFGDPVVDIRESTADTAKTIMGKVSEHGVKSILPSLLLGLEENNWRSKKGSIDFLSSMAYCSPYQLSSSLPIIIPRLTEMINDSHLQVRSAANDSLLKFSKIINNPEIQKLVPTLLKSLSNPNEHTESALDLLHEFSFTSSIDSTLLAIIMPVLEQGLKERSATSRKKAVKIIEKISSLIETSDFIPYLDTILLSLRKILIDPVPATRETSAKALGTLVKNLGGANFPHLIPDLLSTLKKDISSIERHGSSQGISEILSGLNIQYLENILPQILENSLSSVSYVKEGYISLFIYLPRAFGPRFQPYIGKIVSPILLGLADDSESVRDVSLSAGKVIIDNYSTKAVDFLLPELQKEIFNENWKIRLSSVQLISNLLFHITGISGKVHLEENINASQHYKNFLLDILGQEKRDSILASLYILRQDSIEQVRSFVLNIWKALVINTSKTVKEILPVIINMIIQCPNTLNKARDSMFIKTLGDLVKKLEDVISSMLLPLQESITRSEPITKVRLSIALTEIIQNSNIESLEPYKNGLIKTIHHCLMDIKDVRKSAALMFSAMYELYGNIVINQILPNLLNSLHSNKNSKNALEALKELIYVRPQNILPILIPKITKVPVSDVNAKIISSFAQVHCPSFKYYFSTIINALVDTLIFDIDVEIEIEVKNAIDSVLLSVYDPEGMNILIPIMLELVKDENWKKQVLACQHLIYFFKFTKQDYSRYFDEFIYVFLSLFDDENDEVVKSAWEAQNAFTASLKKVDMENLIGPTQKVLHNIGMVGTELKAFQLPKGINAILPIFLQGIIFGNAEKRELAAIGISDIIERANSDMLSPFVIQITGPLIRTIGEWYPIQVKLPVLHTLELLLKKVPLLLRPFLPQLQRTFLRCLADPVSDQLRSEASSLLEILATFQPRIEPLINELVNGSNNLHSGVKLIMIKSLFNIISKSDFCINDSLKNILYTLVENNMNINDFQILSYIGRFSMILFKYFDKNNALVFLRSRIFVAEHNNYSILTLNAILVDCSQYLIELDCCAQAVDSIINGCLNNKPYIANNSFLAAGKFLLDTRFNTNLNYTKLIIETLVNCIKNPKITPDANRLILTVISCISKKSYDVIKSHFNLIVPIVFQNVHHISTPIQLAAESAFISLFKITSYDRSFLNKYIATLDSAQAKSIAAYHKRIMTKITTIEFQNHITSYCNDAYQEIMAVGLSFTCDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7P7N1</accession>
    <name>M7P7N1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein STE50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874026.1">
        <property type="nucleotide sequence ID" value="XM_007875835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P7N1"/>
    <dbReference type="STRING" id="1069680.M7P7N1"/>
    <dbReference type="GeneID" id="19895739"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02045"/>
    <dbReference type="eggNOG" id="ENOG502QQYX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_894424_0_0_1"/>
    <dbReference type="OMA" id="DWTAEEC"/>
    <dbReference type="OrthoDB" id="445896at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01786">
        <property type="entry name" value="RA_STE50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052268">
        <property type="entry name" value="SAM_domain-containing_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20843:SF0">
        <property type="entry name" value="PROTEIN AVEUGLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20843">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="1">
        <location>
            <begin position="14"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="2">
        <location>
            <begin position="256"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="42053" checksum="DBDFC783EA3C6E6E" modified="2013-05-29" version="1" fragment="single">MNSFGLLEKAITLWSVDDVIQWLKHINFSQYEKEFQENNISGDILIHLNHESLKEIGILSTGHRLSFLKAIYRIKIDQNIPIEPEHYIPVSLEMEKLSEYDKSEINKTKELTQAIFSYGKHLNEFEKEIRNLKKDLSKIQEDITYIFEIIKDIKLSKKSDDKLTHTGLSLKRFHEKPLQLKTIPTHSQISPIQLDSELDSPTFPTETYKNQLTHSIQDNLEFGMNHNNSNQIKSECAITDESVSPVSSKKSHKSIEMFKSFRIKLNDSCRKVLLSALKEYKINSDWKEYALVLCYDNKERYIELNEKPLLLFQKLQKDEKKPIFILKQIKNPTTLNQPFNFIQEIKKESDISNTFEDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7P7S1</accession>
    <name>M7P7S1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable 26S proteasome regulatory subunit p27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873632.1">
        <property type="nucleotide sequence ID" value="XM_007875441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P7S1"/>
    <dbReference type="STRING" id="1069680.M7P7S1"/>
    <dbReference type="GeneID" id="19895364"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01670"/>
    <dbReference type="eggNOG" id="KOG3129">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073146_0_0_1"/>
    <dbReference type="OMA" id="DWGGRGM"/>
    <dbReference type="OrthoDB" id="72325at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000107">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040815">
        <property type="entry name" value="Nas2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035269">
        <property type="entry name" value="PSMD9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18265">
        <property type="entry name" value="Nas2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nas2 N-terminal" evidence="6">
        <location>
            <begin position="16"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="112"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00068021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="201" mass="22512" checksum="EB9D3D478AE9B258" modified="2013-05-29" version="1">MGILINTGTFQNQHELKDILQRIDEIKQELQSLGQVLSQNNVNMETSLIDAEGFPRSDINIVEVRMARARINRLKNDYRGLTDNMQTMLHNINILNSPQVVQEPVYQPFAKVNYIIHKSPADLAGLQEGDLIKKFGTVHAGSHDTLSAVSRLVQASENKEIEILVMRKIDTKETDINLILIPQKSWGGSGSLGAYIIPINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7P818</accession>
    <name>M7P818_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H/ACA ribonucleoprotein complex subunit NOP10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Nucleolar protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Nucleolar protein family A member 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">snoRNP protein NOP10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01774</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NOP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873742.1">
        <property type="nucleotide sequence ID" value="XM_007875551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P818"/>
    <dbReference type="STRING" id="1069680.M7P818"/>
    <dbReference type="GeneID" id="19895468"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01774"/>
    <dbReference type="eggNOG" id="KOG3503">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184680_1_0_1"/>
    <dbReference type="OMA" id="HRIIIKK"/>
    <dbReference type="OrthoDB" id="13807at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904874">
        <property type="term" value="P:positive regulation of telomerase RNA localization to Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.40">
        <property type="entry name" value="H/ACA ribonucleoprotein complex, subunit Nop10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="Nop10-like SnoRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="73" mass="8656" checksum="A2A7C4C17C7E6A2C" modified="2013-05-29" version="1">MYLMYYPDKDGKRKYTLQKVTDSGKKTLSAHPSRFSPDDKYSRHRITLKKRFGLYLAQLRKPSVSFGYNVDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7P8W5</accession>
    <name>M7P8W5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01526</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873470.1">
        <property type="nucleotide sequence ID" value="XM_007875279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P8W5"/>
    <dbReference type="STRING" id="1069680.M7P8W5"/>
    <dbReference type="GeneID" id="19895221"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01526"/>
    <dbReference type="eggNOG" id="ENOG502QUE5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_582692_0_0_1"/>
    <dbReference type="OMA" id="QGRIANC"/>
    <dbReference type="OrthoDB" id="5374328at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018287">
        <property type="entry name" value="Hap4_TF_heteromerisation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF7">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10297">
        <property type="entry name" value="Hap4_Hap_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="78"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="437" mass="50239" checksum="18AE94BF0D03537E" modified="2013-05-29" version="1">MVLSGNTTDSMGNLEISSNSNLETNSENSALIVISKDWSLPPRIKPGRKPSEEPPLTKRKAQNREAQRAFRERRAIRVLELETTIKQQRDHMEKLKQEYLGKIQFIVLENEKLKRKNKQLEEQIIYLKSNFEKAKSYLDFNTDVFFPFSKEDHSNTASICDYSNLIIGESVPLKKKNTSRKTKDMELDDVLFHKKVVKESGFTHNVESKDLYNDLGLLVHQKNSETNYRDQINTDSSLSSLFVPKNDSTMEENDCGFCIGNPDLCLCLQSQNLNNEMTNTTEVDKYILPPILIDNNDEKMAEKIQKDVEKTEKLKILEPSSYTIKNEYEPGSCAQCKADSLSMLFCKTFASRINYNRVSFKSYKDEEKYNCNTNTLTNNSLNNNNFLSCSAAYKTLSQHEKFVKENFRIIVDNLAPGSCGMQIQANRVQETLRLLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7P9B6</accession>
    <name>M7P9B6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="5 6">2.5.1.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = N(6)-dimethylallyladenosine(37) in tRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 7">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="5 6"/>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873079.1">
        <property type="nucleotide sequence ID" value="XM_007874888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P9B6"/>
    <dbReference type="STRING" id="1069680.M7P9B6"/>
    <dbReference type="GeneID" id="19894862"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01165"/>
    <dbReference type="eggNOG" id="KOG1384">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032616_2_3_1"/>
    <dbReference type="OMA" id="WGLHLKS"/>
    <dbReference type="OrthoDB" id="775260at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030666">
        <property type="entry name" value="IPP_transferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088:SF89">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01715">
        <property type="entry name" value="IPPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039110">
        <property type="entry name" value="IPP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="447" mass="51791" checksum="D2C5100F10CE2AD0" modified="2013-05-29" version="1">MQTSLRNICVIIGATGSGKSKLGVALAKAFSGEIINGDAMQIYEGLDVLTNKQPLEERQGVKHHLLGYLNITDAYNVFQYEKEALYIIERLHEKKTLPVFIGGTHYYIQSVLFKNALLSKKKEVGETEEKILDKEEEKKEYMSSHLLNMSTVDLYSHLKEIDPLIAKRWHPNDRRKIQRSLEIYYETGTRPSDLYNEQRQHSDKREVPRFRTCIFWVYCDYKVLDEILDKRVDKMCDSGLFDEINMMYDVWNTLDKQKIDLDVQKGIWQAIGFKEFLPYLQLPKNSKEQTRNRYLLNAIASMKLATRQYARKQVKWIKNKLYPLCKAAGMNIRFYLLDATNLSLWDTQIQNLAISLFSDFLQDKPGPDPLSLNTVAATLLSSEKIHDYASQTYLWKHYTCNVCKTSSGAPLVAVGLPQWTIHVQGRRHKRIAAKLKTKINSLTMENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7P9C5</accession>
    <name>M7P9C5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ADP-ribosylation factor-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01174</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873089.1">
        <property type="nucleotide sequence ID" value="XM_007874898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P9C5"/>
    <dbReference type="STRING" id="1069680.M7P9C5"/>
    <dbReference type="GeneID" id="19894871"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01174"/>
    <dbReference type="eggNOG" id="KOG0072">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_9_3_1"/>
    <dbReference type="OMA" id="MGAGMSW"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031503">
        <property type="term" value="P:protein-containing complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000624">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="147"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="23265" checksum="E200FFD7D6DFF7D8" modified="2013-05-29" version="1">MFIEKRALNEIYKKINEVLLRMGGTFGRLLSHLWGQKEIRVLILGLDGAGKTTILYRMQVGEVITTVPTIGFNMETLCYKNIKFNVWDLGGQTSIRPYWRCYYTCTQAIIYVIDSTDIQRLSATTKELNAILNEKELSNIDLLVFANKQDAPNALNIEEISETLNLVDMKERNWTIIPTSAITGEGLNEGLDWLVNSIKNQNNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7P9J4</accession>
    <name>M7P9J4_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873169.1">
        <property type="nucleotide sequence ID" value="XM_007874978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P9J4"/>
    <dbReference type="STRING" id="1069680.M7P9J4"/>
    <dbReference type="GeneID" id="19894945"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01248"/>
    <dbReference type="eggNOG" id="KOG1947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010840_2_1_1"/>
    <dbReference type="OMA" id="LCNRIRY"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF95">
        <property type="entry name" value="F-BOX PROTEIN YLR352W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="63"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="2">
        <location>
            <begin position="227"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="567" mass="65041" checksum="14CCCE2207591507" modified="2013-05-29" version="1">MGHNALDFCFKTWSKTPMNKLVKSINLEMISDDEGMFHVPSKLLQKPNKSHMPKNRRTISAAERLPSELILAIFKYISSGSDMQSCLLVCWSWCYCSVESLWYRPFLYQSSNLIKFCNTLCRKNLSFNYAQLIRRLNLSYVCDYVSDQYLSKLDKCTRLERLTLIGCKRITDKGIYDILSRNPNLLALDFTGLELITNRTLFCIAKHLKNLQGLNLTNCKNITDESIMAIAHSCSNLRRIKLNGCHLITDLSVLSLTSKCPSLLEIDLDNCFEITNQSANAAFTKLNYLRELRLAQCTSITNELFLNMENERYEHLRILDLTSCTRITDDCIYHISLTIPKLRNLILAKCSNITDRGVMYIARLGKNIHFLHLGHCSAITDRSIIYLSRYCSRLRYLDLACCTQLTDLSICELASLPKLKRIGLVKCANITDLSIFALANHKMAENALERIHLSYCVNLTLHAILELLNTCKRLTHLSLTGVSQFLQPEFTQFCRPSPKDFNPHQQAVFCVFSGSGVIKLRNHLNNLIKEAKIRTQFQHLALEETFEENENNYNVPIETQEVFESFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7P9W1</accession>
    <name>M7P9W1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01359</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873289.1">
        <property type="nucleotide sequence ID" value="XM_007875098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P9W1"/>
    <dbReference type="STRING" id="1069680.M7P9W1"/>
    <dbReference type="GeneID" id="19895056"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01359"/>
    <dbReference type="eggNOG" id="KOG2069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017968_4_1_1"/>
    <dbReference type="OMA" id="DAMKDMT"/>
    <dbReference type="OrthoDB" id="1661054at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007255">
        <property type="entry name" value="COG8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04124">
        <property type="entry name" value="Dor1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="408" mass="47816" checksum="A1306D62E40023E0" modified="2013-05-29" version="1">MSQNVVGDINGSEESYYLLFQPLLTLLNPNFSSLQFHDTSIISYLSELIESSISELSEKQNELNIKDRKATYDLVEIMQKEYDHFITVLNYKNSFSRSFNILDESVNKIQTTITSINEKVLNFESLKDGFNEILTEFRLLHQYQEYILNLFEIPSLIETCIKNNNYSEAINLISYGKKLGDEYFQIDIIQDLVKQVNYMSEYLQRQLLLLLKGTIKLTEAIKVIGYLRRTNEFLEIELCYIFLLSRWNYMDGLISNLNSSNKDNPEKYLKEYIGIFREHSFNIFSYYTLIFLKEESVFYVFSENSENSISTKNNDNLNEKISRRRMLSNFALHMVSELKNTLAKYIPYISDNEVKALILNRILHCGQSLGRIGVDFSLALVDIFGDEWTDLIKNHENMMRNLETSIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7PA65</accession>
    <name>M7PA65_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA-(apurinic or apyrimidinic site) endonuclease</fullName>
            <ecNumber evidence="13">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_00889</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10 13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10 13">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="13"/>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872800.1">
        <property type="nucleotide sequence ID" value="XM_007874609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PA65"/>
    <dbReference type="STRING" id="1069680.M7PA65"/>
    <dbReference type="GeneID" id="19894587"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00889"/>
    <dbReference type="eggNOG" id="KOG1294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010374_2_0_1"/>
    <dbReference type="OrthoDB" id="391817at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004528">
        <property type="term" value="F:phosphodiesterase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09088">
        <property type="entry name" value="Ape2-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000079">
        <property type="entry name" value="DNA-(apurinic or apyrimidinic site) lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020848">
        <property type="entry name" value="AP_endonuclease_F1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF4">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00728">
        <property type="entry name" value="AP_NUCLEASE_F1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="14">
        <location>
            <begin position="485"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="11">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR10740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="545" mass="63671" checksum="4960B65E9AA319B7" modified="2013-05-29" version="1">MRLISWNCNGIRNLFDYQSKKSEKSLKFILEKFEADIVCFQETKIQRKDLTHDMINIPGYLSFYTFSKKRKGYSGVAIYVKESLCIPLKAEEGITGYLIHSGEGIPYIECPKSISIGGYTEMSDKHALELDQEGRCIILDLNLFVLFGVYCPLNSNSERNKFRQLWIETLDSRIRNLRKMKRNIVIMGDINIIRDDVDSSYKIDELQEGMEDFKDSCQRAWLNKLLLPHPEGFMIDLCRHFHPDRKEMFTCWNTKINARTCNFGTRIDYILISKELLPWFEFADIQANVMGSDHCPIFAEIKSQIYNWKGSGKTDNILDFLNKEGAFVDGILVSKLPKPPHLETHNFPEFSFQDIKLMFKKQEKLDSLEKKNKPYTLKNFLGRSATEPLSHFSKKKRLESFSNQSHLPSYFKNASGQLKNLDRKHEKDTSLKKEYNSLDSENINTKTILKISDTLKNDTKRDSEVLELRKKTWNNIFTKPSPPLCNVHQKPCIELRCKKPGLNFGRHFWICSNPISKEYKHQNISDSDMENKFKCGYFRWSSNHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAM6</accession>
    <name>M7PAM6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein SSH4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872969.1">
        <property type="nucleotide sequence ID" value="XM_007874778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PAM6"/>
    <dbReference type="STRING" id="1069680.M7PAM6"/>
    <dbReference type="GeneID" id="19894754"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01056"/>
    <dbReference type="eggNOG" id="KOG1477">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009129_5_0_1"/>
    <dbReference type="OMA" id="LPTRWNK"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12909">
        <property type="entry name" value="SPRY_RanBP9_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035782">
        <property type="entry name" value="SPRY_RanBP9/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="37"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="2">
        <location>
            <begin position="313"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="59110" checksum="7C4D9FED5CD2FC1B" modified="2013-05-29" version="1">MTSVNVLHISQSEIEEPFIPEYLRGTAFAEQYETRYLSFSRYGRNFGIGSDFSELPSSWNEDDKCNLLSLAGNGLEVKFVGPAKGVEQDAASVRANNPIPTRCGLYYYEIEILSKGYEGLIGIGFCKSTVPLNRLPGWESDSWGYHGDDGHSFCCQGIGKEYGPKFTKGDIIGCGINFSSGIGFYTKNGVHLGIAFRDLKGTLYPSVGLRTLGEHIRANFGKKPFVFDIEQYMRMEKLKAFESINSWPSSEDKEYNESSISTIVNNLVASYLSHNGYMESAKTFIQDVEKREKIFASMDKDYILESIDIDDIDSVNRQHIRVAILNGDIDLALKLTNIFYPGLLETNESVYFKLKCHKFIEMMRQCSESGNENDDEIMTDITGVYNNDNVSCFDSLENSSFESRNSKKKNTRFLLSKILEYGQQLQEDYRDDNRSDIRKTLEDTFSLLAYSNPKNSAVSYLLDENARQIVAEELNKAILVFLGKSPISPLERLVQYTSVVISELGKKGSSESSFVNIRRDILGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAQ8</accession>
    <name>M7PAQ8_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01095</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873007.1">
        <property type="nucleotide sequence ID" value="XM_007874816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PAQ8"/>
    <dbReference type="STRING" id="1069680.M7PAQ8"/>
    <dbReference type="GeneID" id="19894792"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01095"/>
    <dbReference type="eggNOG" id="KOG4283">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032951_0_0_1"/>
    <dbReference type="OMA" id="WIPAPRE"/>
    <dbReference type="OrthoDB" id="361494at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070912">
        <property type="term" value="C:Ddb1-Ckn1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042238">
        <property type="entry name" value="Rad28/ERCC8/Ckn1/ATCSA-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202:SF1">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="39"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="93"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="179"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="237"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="367" mass="41631" checksum="40089DE39C3D5657" modified="2013-05-29" version="1">MDRFLVLRSLGAQSSSILRRMQYLKSIWSIDSEPVKQFKKRHFGNIQALVFDNSVERYLLSGGTESLVCLWDLEAEKDAEETSIGPISFIPVHSGHQYEISDINWWPFDQGLFTTSSFDHFVKVWNTDTMQEVCSFDLGEKVYAHTLSLVASHCLVACGTDSSSIRLCDLKTGAFTHSLQGHEGNVLTVLWSPRDDYTLVSGGSDGSVRLWDVRRAISCLKCFHQYNLQIDSTFQRNCSHNGPVNGLAFTSDGFYLVSVGHDEAMRAWDLQDGLNTFIHYGQTIRNTRFQETNPYITHSDESETPFILFPSNDSQIHIFDLFHGNLIKTLNSTQGKVSCVTGKKYSAEFYSGNDHQIFTWLPKKPNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7PBQ1</accession>
    <name>M7PBQ1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_00318</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872192.1">
        <property type="nucleotide sequence ID" value="XM_007874001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PBQ1"/>
    <dbReference type="STRING" id="1069680.M7PBQ1"/>
    <dbReference type="GeneID" id="19894016"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00318"/>
    <dbReference type="eggNOG" id="KOG1750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104295_1_2_1"/>
    <dbReference type="OMA" id="VCIRVYT"/>
    <dbReference type="OrthoDB" id="361013at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000099">
        <property type="entry name" value="Ribosomal protein S12, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_uS12_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR11290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="150" mass="16847" checksum="DDA9EB0F5CFD189D" modified="2013-05-29" version="1">MLILKTLTHWSLNFLKDTSTFSRSTATLNQVIRGARQPRKSPRPKAPRLNGAPFRQGVCNKIYTMKPKKPNSAQRKVARVKLTCGRMVIAYIPGEGHNIQEHSVVLLRGGRVQDLPGVRYHLVRGARDLLGVVNRVTSRSKYGTKKFKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7PC98</accession>
    <name>M7PC98_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bromodomain associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00541</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872431.1">
        <property type="nucleotide sequence ID" value="XM_007874240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PC98"/>
    <dbReference type="STRING" id="1069680.M7PC98"/>
    <dbReference type="GeneID" id="19894239"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00541"/>
    <dbReference type="eggNOG" id="ENOG502S96D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064111_0_0_1"/>
    <dbReference type="OMA" id="TDIMIRY"/>
    <dbReference type="OrthoDB" id="5402929at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037818">
        <property type="entry name" value="TAF8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46338">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46338:SF1">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00576">
        <property type="entry name" value="BTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="5">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR11530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="170" mass="19185" checksum="84B6EC52F0ECAC29" modified="2013-05-29" version="1">MRERFFFSLARISAIQILRSAGITRAKPVVTDSFTDIFIRYILLLGTTAKHFAEISGRPLVEMEDLRAAMENIGLLGVSSTEDDVEPIEIFLNWCKGSFTAELRQLSGQESKPGNSSIGWLDKLMQKHIKEKFQGTVLDNNVETPVPRLADPRIINLSPLHEKIETMLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCB3</accession>
    <name>M7PCB3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Maintenance of ploidy protein mob1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872446.1">
        <property type="nucleotide sequence ID" value="XM_007874255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCB3"/>
    <dbReference type="STRING" id="1069680.M7PCB3"/>
    <dbReference type="GeneID" id="19894251"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00553"/>
    <dbReference type="eggNOG" id="KOG0440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038321_3_2_1"/>
    <dbReference type="OMA" id="VDNEQMF"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035974">
        <property type="term" value="C:meiotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071958">
        <property type="term" value="C:new mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071957">
        <property type="term" value="C:old mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902554">
        <property type="term" value="C:serine/threonine protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034973">
        <property type="term" value="C:Sid2-Mob1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903473">
        <property type="term" value="P:positive regulation of mitotic actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031031">
        <property type="term" value="P:positive regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.30:FF:000001">
        <property type="entry name" value="MOB kinase activator 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="25606" checksum="37513956C52C3FBE" modified="2013-05-29" version="1">MSFFNLNSRTRTLTFKPKKIEENKRRFLLKEYTKETLGSGSLARVVRLPEGEDLNEWLASNTVDFYNQINMLYGTITEFCLSETCPMMSAGSQYEYLWQDSNKYKKPTKMSAPEYIETLLQWVLSFIDDESVFPTKNGFPFPKCFSLIIRQIYKRLFRVYAHIYCHHFSAIVALGEEAHLNTSFKHFIFFVNEFNLIEKKEYAPLQELVDSFITNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCJ2</accession>
    <name>M7PCJ2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell division control protein 24 OB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871920.1">
        <property type="nucleotide sequence ID" value="XM_007873729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCJ2"/>
    <dbReference type="STRING" id="1069680.M7PCJ2"/>
    <dbReference type="GeneID" id="19893762"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00064"/>
    <dbReference type="eggNOG" id="ENOG502S2YX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039318_0_0_1"/>
    <dbReference type="OMA" id="EHVNPPF"/>
    <dbReference type="OrthoDB" id="3248508at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052469">
        <property type="entry name" value="MEIOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21166">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24 OB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21166:SF2">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24 OB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="54393" checksum="D90B2565E6165859" modified="2013-05-29" version="1">MEVFPCEKAFYKNIFEKNTSFDDKWEAGNGFEPNNLYSKHSEIYQDNWYPKIKYEETKIKELSESNSPIALTGRIVNIYEINNQKNIENTLILIYIKDETDVVEVKYWLNKRNVKEIHYNLKIDTLCTAFVTKTCIKKEDISRFKKASTVPFYVIVSDDNEITHLSIFKNQDKIYKKPLKIQKDCIIQDLMSLSTFINGGYMAISKPKVLVSIRKIGNIRKINTKNGYSDMIELRVFDDTYDAVLILWGNNAKSAELWTPFDTILLLTDVSLSFRCEKAYLTFQKYSIVEVNPDMDIEWLRKYSTDISNKVSDMHKLSLEDRIISTSPTMATYTLAEIDTMIRLNPKEPIIGFINVLIVKTAKLSTLRSSNKIFVGKCCDKVINALDNNVKCSICHQKIKLFNDSFIIGLLDESAQLLYPMLNLYNSSNSELDDFSDTILYSRILFLFGIERNDDIWKVNLIKIVDNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCL6</accession>
    <name>M7PCL6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_03374</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875457.1">
        <property type="nucleotide sequence ID" value="XM_007877266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCL6"/>
    <dbReference type="STRING" id="1069680.M7PCL6"/>
    <dbReference type="GeneID" id="19897061"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03374"/>
    <dbReference type="eggNOG" id="KOG1472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_819201_0_0_1"/>
    <dbReference type="OMA" id="ANCKMYN"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398:SF4">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="248"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="81"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="339" mass="38576" checksum="EE63A5C86E886B27" modified="2013-05-29" version="1">MNDIWNGTSSLLLAQLVLKHGTDFSIIQTHLSQHPLYHQPISSTEDIKAHYELLLKENELKEDETNASKDSLISNASKLCKILYEKRIIELKKEIQREEEAYKKITEEIEEIRCGRWPTSLNISEQTIKSENNVENSTDISSASVVVERKGRHDDIASSLNTENAVPEIGDNVVSVETIPDQGSECQEKIENIKKQNVKKNTRNLVKKEIDIFQTENISENSPKPSASELTSLKRFQSMILPLWMSLSQHKHGTVFMGPVSDKDAPGYSSLIHFPTDMKSIRNKIRDGKITTSKQFHREVLLLFANAIMYNGENSTITQWAKEGFAYSEEMINIGRRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7PD33</accession>
    <name>M7PD33_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00212</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872080.1">
        <property type="nucleotide sequence ID" value="XM_007873889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PD33"/>
    <dbReference type="STRING" id="1069680.M7PD33"/>
    <dbReference type="GeneID" id="19893910"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00212"/>
    <dbReference type="eggNOG" id="KOG0825">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_487547_0_0_1"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047157">
        <property type="entry name" value="PHRF1/Atg35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12618">
        <property type="entry name" value="PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12618:SF20">
        <property type="entry name" value="PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="17"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="125"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="64570" checksum="D50EE0194A7313DE" modified="2013-05-29" version="1">MGHEKIIRSSYEEENLCSICLSPFSYLEKEESVIKENNIEKNIEDCLKPRKTDIAYLGNCRHFFHYYCIELWVKIANTCPVCRYCFDYISLSRFLGGPIFAHHPVEKRVKSVDFEALNEEDICRCIICGSCEDEQVLLLCDGCDDGYHTYCLGLDEVPRQDFFCPTCITLSEEYFSYAPRRRGAMRRSGLLIIGQRVNRNNHSGRVSSGLNRSTRQERMRNISLNNRWFQRAYHDYGLWGIRNNEAGGERNHTSTSLAYRDESSYNSGKSRSGLLSLSPEEKAWKMYEVQKCGEKIEKYDDSFKDDFLSLTSQKKFKRPLIARNEIKNMGYTSGERISSVSNDDYSISYVKGKAKENNDSQLGFLQNLLNDISNTSNYSYQLKHDTESFENYYNKVSYDSETSKKKNSSVFISNVSFTDDNTQKDSFQSISDTFSGTQSKKVYHSSAMSSSMALSESFLTTFSSFSSKSTSKSPIISPGRKIAFTIKKKIEKIVSKELRLYYPEKISKDTCKSINKRVCRMIYEDVALLGEHMFDDFDNLWYDKIKTEIMRLIKDIGHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7PDN0</accession>
    <name>M7PDN0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">INO80 complex subunit B-like conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_03051</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875106.1">
        <property type="nucleotide sequence ID" value="XM_007876915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PDN0"/>
    <dbReference type="STRING" id="1069680.M7PDN0"/>
    <dbReference type="GeneID" id="19896738"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03051"/>
    <dbReference type="eggNOG" id="ENOG502S7M7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_956827_0_0_1"/>
    <dbReference type="OMA" id="FIIMPKY"/>
    <dbReference type="OrthoDB" id="2021186at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029523">
        <property type="entry name" value="INO80B/Ies2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006880">
        <property type="entry name" value="INO80B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561:SF12">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04795">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01406">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit B-like conserved region" evidence="3">
        <location>
            <begin position="151"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="291" mass="33459" checksum="97A808E89D06FADF" modified="2013-05-29" version="1">MKSTSSADISESEELIDQSRKQASDKILVKSKDMEQEKSLRITIRVPSRCMTGKRSRRRRIEAIESISESELDELSSSNDFEETVLEESLDTDDSEEYIERSRELKEKVGELTRLTKRQRARIDEDAVETNDLVQLPETIKRRHQNLTEEELALKRNELARRRKNLSEQKLEEEKMGTINKLLSKQVMHKYKRIKVDDEGASEEEKNVPKVSSPIMSRWIDRKEGTVFAIPKKWLDINVSTYFEAQKGSVPSFSQRLCSLCGGVGIYNVIGSVVPMRACSISCLRLIQSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M7PDP6</accession>
    <name>M7PDP6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875126.1">
        <property type="nucleotide sequence ID" value="XM_007876935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PDP6"/>
    <dbReference type="STRING" id="1069680.M7PDP6"/>
    <dbReference type="GeneID" id="19896757"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03070"/>
    <dbReference type="HOGENOM" id="CLU_1175851_0_0_1"/>
    <dbReference type="OrthoDB" id="5301000at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004330">
        <property type="entry name" value="FAR1_DNA_bnd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718">
        <property type="entry name" value="OS01G0519700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03101">
        <property type="entry name" value="FAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAR1" evidence="1">
        <location>
            <begin position="53"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="236" mass="27056" checksum="1F6493680086622C" modified="2013-05-29" version="1">MESTDSTSSTVVDNNIANIHYTIHPVDSQNLIPQPQVGVHYASPEDIRAMLDAYAKFKGFAVSVRASNRITYRWQCVHGGKYRNTRNLPNEITVDPVIVSDPTIPHRQRKQTTKRTNCPWLVRAGLSQSELWKITKVVDEHNHRLYPEDPTIYHQNRPMTKQRVQRKKPRKPSARILEQQMTNTALSSTPLNNMESTLKIISLVPQDFEQGIMDPELDIDLDESIMRTIGTQTEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7PET7</accession>
    <name>M7PET7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome maturation factor UMP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the POMP/UMP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874785.1">
        <property type="nucleotide sequence ID" value="XM_007876594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PET7"/>
    <dbReference type="STRING" id="1069680.M7PET7"/>
    <dbReference type="GeneID" id="19896445"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02754"/>
    <dbReference type="eggNOG" id="KOG3061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100687_0_0_1"/>
    <dbReference type="OMA" id="HESKMEL"/>
    <dbReference type="OrthoDB" id="15001at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008012">
        <property type="entry name" value="Ump1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828:SF3">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05348">
        <property type="entry name" value="UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="16526" checksum="7B13D4E81A5E4E29" modified="2013-05-29" version="1">MIPCFSRLPESLIFPIQTTSSQSVKTIHDTFRFGLKSSELDINSYHDLEVFLKRWKYEEHESKMELLNRIFGISEPIRRKMELKIIDSEFRPIIFGRSSNIHHDILTGNDSSVDIDEIFLGDEDCFVDFHSELEKRIFIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7PEY4</accession>
    <name>M7PEY4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_02797</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874830.1">
        <property type="nucleotide sequence ID" value="XM_007876639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PEY4"/>
    <dbReference type="STRING" id="1069680.M7PEY4"/>
    <dbReference type="GeneID" id="19896486"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02797"/>
    <dbReference type="eggNOG" id="KOG2464">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_559165_0_0_1"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072354">
        <property type="term" value="F:histone H3T3 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024604">
        <property type="entry name" value="GSG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419:SF18">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12330">
        <property type="entry name" value="Haspin_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01331">
        <property type="entry name" value="DUF3635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="180"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR09024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="510" mass="59952" checksum="68C3CD9F9E8803CA" modified="2013-05-29" version="1">MNELDINKNKKVQRKTYGKSRYFGDTFENFKVWNDIGNSPNLKKKDNKCINTPEKGKNESSFLSRIRLPQEYFGSLVKDASFLYKISVKQNYEKSPIIKFKEPFQCQENIMLDTFSFSGKDDLEIEESIIESLEDNINLNKDFIKNEVKKESSIIGSLLSFATQTNVYEFSDYISSLLSKYSISKLGEASYSEVYLIKTENYDETVLKIIPFGKEGQITSQEVLHEVRVTTKMSSIDGFVKSKGFVIVKGMYPEHLLFLWDKYNEVYESENSRPDSYDKDQYFCILLLEKGGKDLEHVNITTWRQVNRIFWDIVKVFSQGEKLYEFEHRDLHWGNVLVDDISDSSEDMLSQLSLNSACFSQPCIIIIDYTFSRLRCDDNIGELTWNNFEDHEIFEAHGDYQYEIYRLMRDYASSSKKMWSDFIPRTNVFWLHYLIDKLIHCKGLVRPPARMSKRKNSIQHAYTEIERMFYERAELIWKMINPKKKGSEKKSIEFNSSEDVLSWGMREGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M7PFC7</accession>
    <name>M7PFC7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sld7 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874514.1">
        <property type="nucleotide sequence ID" value="XM_007876323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PFC7"/>
    <dbReference type="GeneID" id="19896196"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02504"/>
    <dbReference type="HOGENOM" id="CLU_1142967_0_0_1"/>
    <dbReference type="OrthoDB" id="5295136at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041260">
        <property type="entry name" value="Sld7_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18596">
        <property type="entry name" value="Sld7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sld7 C-terminal" evidence="1">
        <location>
            <begin position="170"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="243" mass="28300" checksum="A7869FB53AA19F31" modified="2013-05-29" version="1">MSKLVKEEPESTSKYVPKISKISFLLKRRLPVKLKTKNWHGHFCLEPISFENIHKNQQNTIDILDKNTTPLIHSSLLSAILVANVQICNIPFWKCYGPQLQVCAADKYIKAYFARWESKRAPSGDSLSGWVLQWSDGTRALLYGHSLPGQPFRILCSFFNPSKFIARVAEKNKQSLQRLIMAALRLRGIERTHEEFKQLYQHIWMATIFACRQNINQQWIPIDKQQWIIERFVGTFLLEEIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M7PFF8</accession>
    <name>M7PFF8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_02532</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874544.1">
        <property type="nucleotide sequence ID" value="XM_007876353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PFF8"/>
    <dbReference type="STRING" id="1069680.M7PFF8"/>
    <dbReference type="GeneID" id="19896224"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02532"/>
    <dbReference type="eggNOG" id="KOG1867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_484070_0_0_1"/>
    <dbReference type="OMA" id="YIQGASC"/>
    <dbReference type="OrthoDB" id="2020758at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02662">
        <property type="entry name" value="Peptidase_C19F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="95"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR09194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="564" mass="64733" checksum="E2B37B8523F3CEC0" modified="2013-05-29" version="1">MLKNISFKCIKDFISLIPWFSFFWFIIVLITSYIYIGMFFNFPSLLDFYTMFFDILEEKKKSIIEKIFGKNIFDKIKLQNLIKNETNIKYEQTIGGLYNSGNSCYINCILQSFASLNELEYILEKLSKEHDNPIASATFSIIFKLNHSSSLSRTHSTSKLIKTLSLNKKIFDYEQQDAQEFFQILTTQLNTEILKMSKKCTEKGFSGSIKTRSENSNIENEIKSPFDGLMANRLECINCGFSEGIIHSSFTSVSLPLLSSQELCSLEDCLSAYVNKEMIEDILCQKCSLIASKKDLEILLKSLPNSEMSQSIKKKLNAIISALETEVLDAEYLKDFKLPRLVNSIKSKQIMFARLPKILTLHINRSTISPINGTIYKNTASITFPLILDLNRYTTSYSTLWIDPIQTTSIPINQKNQSKYELKSIIVHYGSHTFGHYVTFRKTLRGWFKISDRNVRACSIEEVLHSGNVFMLMYEQIKDSLNINQIIQNFRSENYTKAYSIKCLSSVFNNGKENYNEGFQAEGRTQNSLGVSTINDTNYLYPIMKTCITKSSLYSPLPIISKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7PGK6</accession>
    <name>M7PGK6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin-like protein ARP6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Actin-like protein arp6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02178</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the SWR1 chromatin remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874161.1">
        <property type="nucleotide sequence ID" value="XM_007875970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PGK6"/>
    <dbReference type="STRING" id="1069680.M7PGK6"/>
    <dbReference type="GeneID" id="19895871"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02178"/>
    <dbReference type="eggNOG" id="KOG0680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027965_1_1_1"/>
    <dbReference type="OMA" id="FFEEYEC"/>
    <dbReference type="OrthoDB" id="6220758at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10210">
        <property type="entry name" value="ASKHA_NBD_Arp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000014">
        <property type="entry name" value="Putative actin-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.36.70">
        <property type="entry name" value="Actin, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00063309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="412" mass="47395" checksum="C0886EA754D414F0" modified="2013-05-29" version="1">MTILVVDNGGYSVKYGFSSDNFPRISPNCIAKSVFERRTYIGSQISGCKDFSSLRFRRPIDRGYLVNWESEKAIWDYLFSQKDFRVDYSETSLLVTEPPYNFPQLQSAYDQIIFEEYEFQSYYRCIASSLVPWNNSEIYGTSKEMNGPREFALVIDSGFSFTHVVPIILGDIQWKAVKRLNVGGKLLTNYLKEIISFRHYNIMEEFCLADQIKKSCFFVSSNFNEDIEISKGKKPGNVSIDYVLPDYSTNNQGFVLTSNSQRDMIKERQILTLKNERFIVPEVMFNPSIINLSQAGIHEAIMQSLKLVESDFQELFLANIILVGGNSFFKGYSERLKKELQSLAPAYCKIVIYQPHNPDTFAWVGGSSLACNTKIFDEKKVTRAEYMEYGSNIFLKKSGLNLNKEHDLVLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7PH21</accession>
    <name>M7PH21_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase III subunit RPC3</fullName>
            <shortName evidence="6">RNA polymerase III subunit C3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_01934</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873910.1">
        <property type="nucleotide sequence ID" value="XM_007875719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PH21"/>
    <dbReference type="STRING" id="1069680.M7PH21"/>
    <dbReference type="GeneID" id="19895628"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01934"/>
    <dbReference type="eggNOG" id="KOG2587">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023294_0_0_1"/>
    <dbReference type="OMA" id="KHRFVRH"/>
    <dbReference type="OrthoDB" id="272392at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055207">
        <property type="entry name" value="POLR3C_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013197">
        <property type="entry name" value="RNA_pol_III_RPC82-rel_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008806">
        <property type="entry name" value="RNA_pol_III_Rpc82_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039748">
        <property type="entry name" value="RPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08221">
        <property type="entry name" value="HTH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05645">
        <property type="entry name" value="RNA_pol_Rpc82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22536">
        <property type="entry name" value="WHD_POLR3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase III subunit RPC82-related helix-turn-helix" evidence="8">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III Rpc82 C -terminal" evidence="7">
        <location>
            <begin position="145"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase III subunit RPC3 winged-helix" evidence="9">
        <location>
            <begin position="427"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR09749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="588" mass="69709" checksum="2804D1BD073E7B1A" modified="2013-05-29" version="1">MSQYAIELCQLIIEDFFGQIVLATVNTLFFHGRLSLGEICKISKLQKKYVKKALVVLIQHNFVLFSTVIEGFYELTYYETTWKEILNILRYGKEILIISKKISKEAGAILKYIHCHGKVKVQDLYAVFCPLKDKNNEEYISVQSTITHMLQKRYLRVVLLHQLKPDYDLENDLRNKELEKNRFSKIGETKKSKEILKNIKKNLQSLKDEEMDPNLGLKKKDVDLIEQRYKRQKKNGDSSYILDENVFLRVNHEKFITISRNADLVQLVENRIGKATAQVYCHILQQLEVQNNSNNQENTITTMSILQTFPKDIDLSKTFITVPDNDNKSIKMDSDEEIPLINDFYPNETPDKMAIDTNEFSKKLEEDDTSRIYDLNYRERLKHIVQHLEALSQDSYPLLFKIEAKHFGKWKVDYKQLSCLLQELEYEKIIEHKFGYIATRLLRIIREKGKVDEKQLASIAFLKQQSIRPILMALTEIGALDIQEIPRRSERQPSSIYFLWFHRFERAKSILIDSIYQEISYYHRHLKNELKQRQKLLTKIERTDVQEHEKELLPVNEQQELKYFRAIEEKILIQISRLDRLIMILRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M7PHF1</accession>
    <name>M7PHF1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874040.1">
        <property type="nucleotide sequence ID" value="XM_007875849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PHF1"/>
    <dbReference type="STRING" id="1069680.M7PHF1"/>
    <dbReference type="GeneID" id="19895753"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02059"/>
    <dbReference type="eggNOG" id="ENOG502RSH2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_553328_0_0_1"/>
    <dbReference type="OrthoDB" id="5421270at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082896" evidence="2">
        <location>
            <begin position="20"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="493" mass="56012" checksum="44E864EA320270AE" modified="2013-05-29" version="1">MRAFIFPTFLLITQVFSRGLEVSEFIKDSAVPENERYIKFYRELLDNPAKELENPITDKEKNTLELIRKVHSSLSIEKHFENQDDIINEPILGELTNHFKHDFSIDKCINLTSICCNVLNTAENKNKETLKGICSNKEKFCTNLLKYFNIICTQVKDEQEKIVDFTKEICLKECQRCNDFEEKCNGILNNTCIKVREECKKFNNETKAPEKPETPNNPKKEDKPKKDEPKKEDDPKKEDEPKKEDEPKKEDDPKKEDEPKKEDEPKKEDDSKTDDISESYLTEYEAITSFETVPVTEYTGTGTIIAHVTTTTLEVPETSTILETQIETVTRCNCRCRYSTCTQTIINDCPTPKPTEEPAGEPAGEPAGEPAGEPAEPTEEPAKEPVEEPTEEPAKEPVEEPVEEPAKEPVEEPAKEPVEEPIEEPAKEPVEKPIEEPAKEPVGEPTSESITKTKPTNKSGERNKGSGTKIERLYNNKMIFTIVGMITGIWIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7PHN3</accession>
    <name>M7PHN3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alkyl transferase</fullName>
            <ecNumber evidence="12">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_01727</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>n isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = a di-trans,poly-cis-polyprenyl diphosphate + n diphosphate</text>
            <dbReference type="Rhea" id="RHEA:53008"/>
            <dbReference type="Rhea" id="RHEA-COMP:19494"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:136960"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms an active dehydrodolichyl diphosphate synthase complex with NUS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="12"/>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873691.1">
        <property type="nucleotide sequence ID" value="XM_007875500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PHN3"/>
    <dbReference type="STRING" id="1069680.M7PHN3"/>
    <dbReference type="GeneID" id="19895421"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01727"/>
    <dbReference type="eggNOG" id="KOG1602">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038505_0_4_1"/>
    <dbReference type="OMA" id="FDRRDLW"/>
    <dbReference type="OrthoDB" id="4173905at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1180.10:FF:000002">
        <property type="entry name" value="Alkyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR09969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="268" mass="31458" checksum="5C47C3DB7A5C58C7" modified="2013-05-29" version="1">MGNTIKWFFQFPLFQFLSREFRELCILAIRQGPVPTHIAFVMDGNRRWAKHMNLESADGHSRGFENMKHILEICYKLGIKVVTIYAFSIENFKRTKHEIDIIMDIGKTQLTQFCSHGDMVDEYGIQLNVLGQKSLLKPDFLELIEKATNMTKSNTRAILNICFPYTSRDEITTAIREIVNKSKHGKLDIEKIDETTLDQHMFTHGCPPLDMLIRTSGVQRLSNFMLWQCHKTTIIKFVNCYWPDFNAWRFLPLILEYQLSLFREKLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7PHY6</accession>
    <name>M7PHY6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01830</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the RFT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873801.1">
        <property type="nucleotide sequence ID" value="XM_007875610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PHY6"/>
    <dbReference type="STRING" id="1069680.M7PHY6"/>
    <dbReference type="GeneID" id="19895524"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01830"/>
    <dbReference type="eggNOG" id="KOG2864">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023360_3_0_1"/>
    <dbReference type="OMA" id="WPGKLFG"/>
    <dbReference type="OrthoDB" id="9979195at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034203">
        <property type="term" value="P:glycolipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007594">
        <property type="entry name" value="RFT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MULTISPAN TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117:SF5">
        <property type="entry name" value="PROTEIN RFT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04506">
        <property type="entry name" value="Rft-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="341"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR10079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="552" mass="63710" checksum="F52D23D1850FBBB8" modified="2013-05-29" version="1">MDAIENKSQFAPDFLVNPITNISYLISLQLFSRLITFILNQLILRIVTPEVFGLEMVQMELVISAILFLSREGFRVALQRHDILKQNKGKEIVNNEKKFIKDDYQSVINQGLVNLAYIPIPISILLSILVFFSYTWLANDSTKKQPIFKGTLFLYAFSAIIEIFVEPLFILAQQNFLYKIRAISEAFAIFLKCFITFILAYWCSLNGGIENYGALPFALGRLGYSIILFLSYFILLLNHLQKNLCFFPKKIYSPYDRRVYLFHRPTLILAITITAQSLFKYILTEGDRILVTWYMTDFDQGVYALVANYGSLIARLIFNPIEELSRNLFSKLCLRKDKDSYLLAQSILFIVIKLYIIFGIFIVTFGPLYCVAFIKVVAGSKWSKTYAPSVLKLYILYIPIMAINGITEAFVQAVATSNDIKAQSYWMFFFSGLLMFMGCFFLNYFKLGVNGIIFINIINLSARAIWCFVYIYHYFEGLVISLIFPSKTVFFYSILIGYFIRLKTHSIVTIPDMLISMVIAGSLLFICVYKERGSLKTLYRQYYLAKTKNKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7PKE5</accession>
    <name>M7PKE5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01070</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872981.1">
        <property type="nucleotide sequence ID" value="XM_007874790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PKE5"/>
    <dbReference type="STRING" id="1069680.M7PKE5"/>
    <dbReference type="GeneID" id="19894767"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01070"/>
    <dbReference type="eggNOG" id="KOG0201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000022">
        <property type="entry name" value="Serine/threonine-protein kinase 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="377"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="395"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR10924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="481" mass="55833" checksum="34A816C820F48BA4" modified="2013-05-29" version="1">MLEINILSQLNSQFVTRYYGSYLKNTKLWIIMEYCSGGSCSDLMKPKPIEEDYIAIIIREILRGLEYLHSEGKLHRDIKAANILLNSSGDVKLADFGVSGQLTATMSKKNTFVGTPFWMAPEVIKQSGYSFKADIWSLGITAIELAKGEPPYAELHPMKVLFLIPKNEPPLLDGPFSPIFKDFVRLCLQKDTNNRPSAKELLKHRFIRMAKKTSYLTELIERHERWKVQSRYCRYDEDSGAENEELAPNTFDTYWNFETLKCETKLKNKIQYIKDPSNKLHNNRKETDKLQKQQVDYHISQQLPPNSFIEIDDSDYYSNTIREIYFRKENIPPSELIKESFSLAQIPLNSKEETLSNPKLSPYSKNSAQMECSANRNCNSYDNSQQSNNFISQNHTNLTNSSPNSPKKQTQWRIAITHAFKKLEKRHFTSSETLIYVRKLKKTFQEIEENCPNLINILMNEIIADENVKEYSENIQNLQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2024-01-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M7PKF8</accession>
    <name>M7PKF8_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872996.1">
        <property type="nucleotide sequence ID" value="XM_007874805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PKF8"/>
    <dbReference type="GeneID" id="19894781"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01084"/>
    <dbReference type="HOGENOM" id="CLU_2997471_0_0_1"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="57" mass="6667" checksum="909E1E3014EEF807" modified="2013-05-29" version="1">MVQTPRQRQGNEIYAIREAAKRGKSKTEKPLLKKLKPNISIYWVCKCINKSQVRCMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7PKG1</accession>
    <name>M7PKG1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM20/NAA25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873001.1">
        <property type="nucleotide sequence ID" value="XM_007874810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PKG1"/>
    <dbReference type="STRING" id="1069680.M7PKG1"/>
    <dbReference type="GeneID" id="19894786"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01089"/>
    <dbReference type="eggNOG" id="KOG2053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008075_0_0_1"/>
    <dbReference type="OMA" id="WKRREHQ"/>
    <dbReference type="OrthoDB" id="1874341at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019183">
        <property type="entry name" value="NAA25_NatB_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF3">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 25, NATB AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09797">
        <property type="entry name" value="NatB_MDM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="846" mass="100302" checksum="16EFEE670DC4638F" modified="2013-05-29" version="1">MRVQTIFDALDEGFPKMALQMCTKVLKKSPESQIYQALSALSLLRIGNYEKALEISENLRKKLPIDQDVLNVLQIVFQELNMADNAIEMFENALKKKPNDEEFVRNWFFSMVRTNNIRGQQKAAMSLQKIFGKRKYYYWAVMSLELFKMIKMSESEKQFFQTLSYRLILKTTEKNNELYRLSSSEELHLYIRVLLFCNKLEDALDVLENDIFKSFIDVDLQRVKLDLLFELKKWKVLFSQCCNYLDDGNNDWKIFDMQINAALNLAGSDSSSSVLLDLANYYKEKKQKFPYLRNLALASLKLSFLISDNGMTDDKLNSCIQYFEIFSLKTSCFEDLRPFVEKLEKKHQDRFLIHIFEFCKAKIYDMKKNYVEVLKNVKKFEYLINYCEFKDENAWVMFSLQLAKEYGNSLFLDDHLNVTDKQYGDDFLILSVHALINTFFIGNDQSYLIQAILFLELGLLHSKYNFQFKLLLVRLYCMIGAFSLALFTYQSLSIKQIQYDTLSYIFMTKCSNYYPSKSFQNELRIAKYIYISNIKEVPEMLVLAYENGSYSNIDNFIEFATRLNNSIWRYMLRYELLHLSYLIDNKISDEIIGNNGFAREEYYDNRDFTIMVDFGTIKDKSKQIKNRIISAPDESWLKIQNFKMSFVNLLISGTIEDIKVKSKSDEWLLDGLKFDTLSEFEMQMMFLFRVFLCFLIQIADQKAYDIEENRLKEWIERNLVISFVNVSNYNDNILEHFVFLLESCKSILIFGSFIKRSFKTLRKLHTEIKKIEEIVRNFHKDIILYVSSLKDKIVIVDFTKFVVLFEPNFQLFKIDKHFIEMILEKINDSRRNSLDNLNNIIFNMKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M7PKH2</accession>
    <name>M7PKH2_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873011.1">
        <property type="nucleotide sequence ID" value="XM_007874820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PKH2"/>
    <dbReference type="GeneID" id="19894796"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01099"/>
    <dbReference type="HOGENOM" id="CLU_2159493_0_0_1"/>
    <dbReference type="OrthoDB" id="5415050at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="111" mass="11590" checksum="BCF3F58D8B367F14" modified="2013-05-29" version="1">MHFHITSICITIAMFFVMIRGAAFGGVQLVRRDTKEVVKQIANDTGLKPLLNATNQSGSHGSIVEVALDTSNGTALKPTGGSDPNGSIRVSIATGTFVLVILAFIGSLASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7PKL8</accession>
    <name>M7PKL8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872502.1">
        <property type="nucleotide sequence ID" value="XM_007874311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PKL8"/>
    <dbReference type="GeneID" id="19894303"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00605"/>
    <dbReference type="HOGENOM" id="CLU_774158_0_0_1"/>
    <dbReference type="OrthoDB" id="21589at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039751">
        <property type="entry name" value="HERPUD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943:SF27">
        <property type="entry name" value="HOMOCYSTEINE-INDUCED ENDOPLASMIC RETICULUM PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943">
        <property type="entry name" value="HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UNIQUITIN-LIKE DOMAIN HERPUD PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR11004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="41238" checksum="D47A50BD93AEA4BB" modified="2013-05-29" version="1">MRNQNMHSIDDDKGESFCKTKVRIKSSVVPYLSEFTIEINRNLTVGVLKNQISSLFKGYINTLDYQLIFDGCVVGNDQNISRFIKDDSNDVTFHLITVSKILSSSSVSQDLSMAFNVFSNDLFNHGFSGTDKTEQNVFDEGNDSSSNDRRHIRLPIYYQAAVVDNKPCLFKISNYPSVSVLNSGSVFSIGDDNSCQILLMSPENASQYLNQNLQNDSQFSRTAINPDPHPQDHNVNNDRLRMAFVHLWLFIRLAFFVGLFSVNSSWIRFCTLVFIALQFFFWHTGRLISIRLFFQRIINRDRDRDPSRNERSSLNSEHGFSQPTSYDQEDTEPVEFNWRRNLGHKILTFIISLFPLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M7PLG0</accession>
    <name>M7PLG0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872176.1">
        <property type="nucleotide sequence ID" value="XM_007873985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PLG0"/>
    <dbReference type="GeneID" id="19894002"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00304"/>
    <dbReference type="eggNOG" id="ENOG502S7BG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_888823_0_0_1"/>
    <dbReference type="OMA" id="IKNFLTW"/>
    <dbReference type="OrthoDB" id="5286775at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="313" mass="36380" checksum="DC12AEF358A070E3" modified="2013-05-29" version="1">MDYSSEDKENDYFAQENFPADISPRLALLFTRIQYRGTQPLFPASWKIDFLGLPSTLFVQSNSNFRPPICSMNNTDSGEFRGKLAFKRLVFLGRDIRDRIQLNKEYRLPHDSLAIEPYILSELKRFQQWMEKDSVGLFNLEKTKIPYLIYVSSCYSDFSKNVNMNINNDYMIVAEKMENKLREAAQYHRQRILSKYADRYSIYNPPTPPHEEYENTQVVTIDKFPTIYGFAICRSQVAIVSLNSSDLKNPIRTLLVIDYCNVTQDLWSAIAIALTMVASRDETIEWSYFGGTNEISNLTKQMANVKMTEDVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7PM12</accession>
    <name>M7PM12_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872410.1">
        <property type="nucleotide sequence ID" value="XM_007874219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PM12"/>
    <dbReference type="STRING" id="1069680.M7PM12"/>
    <dbReference type="GeneID" id="19894220"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00522"/>
    <dbReference type="eggNOG" id="KOG2912">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027534_0_1_1"/>
    <dbReference type="OMA" id="EHKIDNY"/>
    <dbReference type="OrthoDB" id="514248at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120048">
        <property type="term" value="F:U6 snRNA (adenine-(43)-N(6))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120049">
        <property type="term" value="P:snRNA (adenine-N6)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010286">
        <property type="entry name" value="METTL16/RlmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393:SF0">
        <property type="entry name" value="RNA N6-ADENOSINE-METHYLTRANSFERASE METTL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05971">
        <property type="entry name" value="Methyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR11509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="48327" checksum="8958CA19183AD7FD" modified="2013-05-29" version="1">MTYHNFYLDNPPNFSELAEKYPSLKPFLDNQSHVNFKNPAALREVTKCLLKHDFKIDIFLHEKRLCPPVPNRFAYILWIQELIDFVNCDEKKKVVAFDIGTGSVCIYPLLCCSQRPNWFFYATDIDELSLELARENVKRNCLDNQIKIVDTAKYSTLIPLDELNISKIDFCMCNPPFYGSEEEILTSSRLKSKEPFSSCTGSLIEMVTPGGEVAFVKRMLKESCVLKERVNWYTTMLGKLSNVTKIIEHLKEIQINNYVINELPVGGNTRRWVIGWSFTDMRAPNHYVRPLTKSLRHLGSSLTMVIIKLDTTIENLRQKISSIIKKFNINFTWNNEYIGNGETPGNLWSRSSRRQISKKNSENSLDVNFKFRLEIVPQTNAEHAILLKVLWIKGIDKIIFESFYSMLRRELRSLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWV4</accession>
    <name>A0A0W4ZWV4_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_04337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="KTW32852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613332.1">
        <property type="nucleotide sequence ID" value="XM_019757849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWV4"/>
    <dbReference type="GeneID" id="30671609"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04337"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KTW32852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="76" mass="8766" checksum="7C80D3E2BB11F4BE" modified="2016-03-16" version="1">MVMENDMLWKCDIEICHQKVRIIRGFVSLFQKLIYILILSLIDNISLSDSLLNKLKDINITSSLKKAIDISNSEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWV5</accession>
    <name>A0A0W4ZWV5_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_04343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="KTW32842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613324.1">
        <property type="nucleotide sequence ID" value="XM_019757854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWV5"/>
    <dbReference type="GeneID" id="30671613"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04343"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KTW32842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="122" mass="14653" checksum="4B1758D3B795AFB1" modified="2016-03-16" version="1">MHLNCGLQNKGTRKIFLVEYKSQRLTLSPYIMESRRQKNVNFNAWNIFLYKLYFIIDSFDRGRIIFSRLQVSVVKNVQWISKRLEANIFLGLNKYQQFNTCYLIARFKVENLLIIICYLSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZX09</accession>
    <name>A0A0W4ZX09_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Multifunctional methyltransferase subunit TRM112</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_04286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRM112 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="KTW32899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613372.1">
        <property type="nucleotide sequence ID" value="XM_019757806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZX09"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZX09"/>
    <dbReference type="GeneID" id="30671577"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04286"/>
    <dbReference type="OMA" id="NMLTSKC"/>
    <dbReference type="OrthoDB" id="2187549at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043528">
        <property type="term" value="C:tRNA (m2G10) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160102">
        <property type="term" value="F:tRNA (guanine(10)-N2)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039127">
        <property type="entry name" value="Trm112"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773:SF0">
        <property type="entry name" value="MULTIFUNCTIONAL METHYLTRANSFERASE SUBUNIT TRM112-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773">
        <property type="entry name" value="UPF0315 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158997">
        <property type="entry name" value="Trm112p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KTW32899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="14741" checksum="CE844A42C008AA8D" modified="2016-03-16" version="1">MKLLTANFLQCVVKKCQSNSKSYPLKFENVHIVQKTLDFNPEFLLNIISRVDWKAFILTLEELFGKVTIPYEKPELTIDEVDLLQELHKLLIETQVMEGNLICRNCNHIYPIKEGIPNFLLSEYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M1FPU0</accession>
    <name>M1FPU0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-ubiquinone oxidoreductase chain 6</fullName>
            <ecNumber evidence="1">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nad6</name>
    </gene>
    <organism>
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="2"/>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="FASEB J." volume="27" first="1962" last="1972">
            <title>Sequencing and characterization of the complete mitochondrial genomes of three Pneumocystis species provide new insights into divergence between human and rodent Pneumocystis.</title>
            <authorList>
                <person name="Ma L"/>
                <person name="Huang DW"/>
                <person name="Cuomo CA"/>
                <person name="Sykes S"/>
                <person name="Fantoni G"/>
                <person name="Das B"/>
                <person name="Sherman BT"/>
                <person name="Yang J"/>
                <person name="Huber C"/>
                <person name="Xia Y"/>
                <person name="Davey E"/>
                <person name="Kutty G"/>
                <person name="Bishop L"/>
                <person name="Sassi M"/>
                <person name="Lempicki RA Kovacs.JA."/>
            </authorList>
            <dbReference type="PubMed" id="23392351"/>
            <dbReference type="DOI" id="10.1096/fj.12-224444"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 6 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="1"/>
    <dbReference type="EMBL" id="JX499144">
        <property type="protein sequence ID" value="AFR90419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_007475009.1">
        <property type="nucleotide sequence ID" value="NC_020332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M1FPU0"/>
    <dbReference type="STRING" id="1069680.M1FPU0"/>
    <dbReference type="GeneID" id="14657966"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="entry name" value="NADH-ubiquinone/plastoquinone oxidoreductase chain 6, subunit NuoJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001457">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33269">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33269:SF17">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00499">
        <property type="entry name" value="Oxidored_q3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0249">Electron transport</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="1" id="KW-1278">Translocase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <keyword evidence="1" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFR90419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="173" mass="19365" checksum="53ECCB1884C191BC" modified="2013-05-01" version="1">MNLEYSTSCLGILLAILVITSKNPVISLLYLIGLFIDMGVYLISIQLTYLGLSYITVYVGAIAMLFIFVIMMLNIKVLESKKNLQSIPLGLLLGSTWVFTLYHILPEDMIIEKYPNVLSFPSWEDRIMNPSVVEILGKVLYTDYSLWLLLISLILVLAIVGAISIAAPHSKCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M1FRL9</accession>
    <name>M1FRL9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADH-ubiquinone oxidoreductase chain 1</fullName>
            <ecNumber evidence="7">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nad1</name>
    </gene>
    <organism>
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="9"/>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="FASEB J." volume="27" first="1962" last="1972">
            <title>Sequencing and characterization of the complete mitochondrial genomes of three Pneumocystis species provide new insights into divergence between human and rodent Pneumocystis.</title>
            <authorList>
                <person name="Ma L"/>
                <person name="Huang DW"/>
                <person name="Cuomo CA"/>
                <person name="Sykes S"/>
                <person name="Fantoni G"/>
                <person name="Das B"/>
                <person name="Sherman BT"/>
                <person name="Yang J"/>
                <person name="Huber C"/>
                <person name="Xia Y"/>
                <person name="Davey E"/>
                <person name="Kutty G"/>
                <person name="Bishop L"/>
                <person name="Sassi M"/>
                <person name="Lempicki RA Kovacs.JA."/>
            </authorList>
            <dbReference type="PubMed" id="23392351"/>
            <dbReference type="DOI" id="10.1096/fj.12-224444"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the complex I subunit 1 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="7"/>
    <dbReference type="EMBL" id="JX499144">
        <property type="protein sequence ID" value="AFR90420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_007475010.1">
        <property type="nucleotide sequence ID" value="NC_020332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M1FRL9"/>
    <dbReference type="STRING" id="1069680.M1FRL9"/>
    <dbReference type="GeneID" id="14657959"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01350">
        <property type="entry name" value="NDH1_NuoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018086">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="NADH DEHYDROGENASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432:SF3">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00667">
        <property type="entry name" value="COMPLEX1_ND1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00668">
        <property type="entry name" value="COMPLEX1_ND1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFR90420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="327" mass="36371" checksum="3B6899472D9A0E79" modified="2013-05-01" version="1">MLLEVFVVILPVMLSIAYTTLAERKVMGSMQRRLGPNIVGYYGLLQPFADALKLIVKETIIPSQSNKILFFLGPTIALVFALLGWGLIPYGPGITLCDFELGILYSLAISSVGVYGILVGGWASNSKYALVGSLRSTAQLISYELILTSIVFVVVFLSGTLNFTQLIESQHSIWYCIPLFPLFIIYFIGALAETNRAPFDLPEAESELVAGFMTEYSAAIFVFYFLAEYGNIILISTLSVIFFLGGYLLPIPSILPPVLQGLFYGVSLGIKVSLLIFLFIWVRASFPRIRYDQLITFCWTILLPFLFAWIFFIAAILYSFNSLPTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7NHT7</accession>
    <name>M7NHT7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_03571</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875664.1">
        <property type="nucleotide sequence ID" value="XM_007877473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NHT7"/>
    <dbReference type="STRING" id="1069680.M7NHT7"/>
    <dbReference type="GeneID" id="19897258"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03571"/>
    <dbReference type="eggNOG" id="ENOG502RJFK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1390766_0_0_1"/>
    <dbReference type="OrthoDB" id="2501249at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052837">
        <property type="entry name" value="Mitoribosomal_bS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_bS21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41237">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP21, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41237:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="23551" checksum="D20A779F6D61ED3D" modified="2013-05-29" version="1">MKIINHFSQNLLNYKVSNFLQEKFILWRTKILIGKYQGKKIKHLSTIPFKCSKETKDKSILFPEKEVNESFYNNHNSKTIEPISSLKKTSRQSSAFFKPLNSLKDSHDLKNKYQKLPIYNRAASREVRNQDIVSSWRSLDILLKQNNVRRDERMGRFYEKPTRKRNRLRSERHRKRFRASIRRLVSIVKEMKHKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NIR2</accession>
    <name>M7NIR2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_03314</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875390.1">
        <property type="nucleotide sequence ID" value="XM_007877199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NIR2"/>
    <dbReference type="STRING" id="1069680.M7NIR2"/>
    <dbReference type="GeneID" id="19897001"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03314"/>
    <dbReference type="eggNOG" id="KOG0031">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061288_9_2_1"/>
    <dbReference type="OMA" id="GVNFTMF"/>
    <dbReference type="OrthoDB" id="429467at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071341">
        <property type="term" value="C:medial cortical node"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120106">
        <property type="term" value="C:mitotic actomyosin contractile ring, distal actin filament layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017022">
        <property type="term" value="F:myosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902404">
        <property type="term" value="P:mitotic actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="107"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="178" mass="20055" checksum="605BF01307C2CE6B" modified="2013-05-29" version="1">MENKEALRKSYSNDYCNSPTHQLKTRSSSGLFTQLTSTQVNEFKESFALLDKDGNGIISKEDLEAMLVSLGQNPTSSDLSYMLSLIPSPLNFAAYLTFFSTYLSEISPREEIMKAFQTFDEDNSGKVNFYDLKDALMTMGSRMSEHQVDNALKKFVNGNFVQYQDLVDALAGSEEKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJ34</accession>
    <name>M7NJ34_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_03104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875160.1">
        <property type="nucleotide sequence ID" value="XM_007876969.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJ34"/>
    <dbReference type="STRING" id="1069680.M7NJ34"/>
    <dbReference type="GeneID" id="19896791"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03104"/>
    <dbReference type="eggNOG" id="KOG1552">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029375_3_0_1"/>
    <dbReference type="OMA" id="WYEGRRV"/>
    <dbReference type="OrthoDB" id="446723at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="117"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="374" mass="42579" checksum="3306CDA303CC4F74" modified="2013-05-29" version="1">MGIISKGYYFVLGLSISYIIFILALLVPFIQRNVFYLHKIRSCSKGDVLEPELLGFSFRRVDPFFLKTSDNENIFVWHVLPYNVYYKNLLKLSEFQEGEELHDFFISLLSKSPKSKLIIYFHGTACNIAARHRLSFYRILTSFDDVHVFAVEYRGFGKSSGEPSEDGLIEDGVSVVKWAIDVAKVNPSSIFLVGQSLGTAVAIGVAEKLSTLKNPIFVGHLVSIAGFSSIRSLLTTYKLGGYFPILSPLKMYPGIRKLIFKFLYHPWNSLERIQVFSKISEKSGTKILFIHSKDDSHIDFYHSFELFVAAVNATVTRENQTWRDLVTLKEKKGEVSIVSNHDNERITYLQVAWGDHNQIILHDTVISRLIHPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJV1</accession>
    <name>M7NJV1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rgp1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874704.1">
        <property type="nucleotide sequence ID" value="XM_007876513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJV1"/>
    <dbReference type="STRING" id="1069680.M7NJV1"/>
    <dbReference type="GeneID" id="19896372"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02681"/>
    <dbReference type="eggNOG" id="KOG4469">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_404444_0_0_1"/>
    <dbReference type="OrthoDB" id="1918at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014848">
        <property type="entry name" value="Rgp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12507">
        <property type="entry name" value="REDUCED GROWTH PHENOTYPE 1 RGP1, YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08737">
        <property type="entry name" value="Rgp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="113"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="680" mass="78808" checksum="932D04D5B5F577AA" modified="2013-05-29" version="1">MSKIRVDIRAKEDYIFAGEFLSFIITFKHEIVGTKETTENWKKQNKSQKEEFYQKKTEDPVRGQSDLLLFKKNKKKTVFLERNTDILEKENINDEEEIEGSISSDMLDISFGKKEKENEEKKLEDKIIKKDKIENNKEAIFDNSENDFSDKKVELEEEQENIDVFYDFNIKSHNLNDLEMNSQLNLDSVKISEGSSENELKETLLIGYIQIIGYFILNEKIINVEKFEEFITNKYSRKSTKDELVRIDSKVNQKSHFINNLNINYRLNNLLKNQPMSSLGKFKKIKKLKNVPILSTPPSILFIDLELAPGESRSYSYNFKLPSQLPPSYEGKSIKINYHLSIGTQCSGKSIQPLKVSNIPFEVLYKIDESGNQIIYDLFSPIIYLTDEAEIFSYDLSENDHISNTEEKSNDLDFGYEYDKYSKEDFICYLSEHLLDESLKKLLLSNSIGENTQECFSDAQEKINPLVDMKNIIQDITENNSSYNNFSNKKFNINKNGNIIGIISILKLSYKLGETIIGVIDFSSSKIPCYHVKFFLETTEIIDESITHCSKANISQTTRKIYDSYSETTLCASRIQFKLLIPSKAPFSFKTSGISLLWTIRLEITIPLTSEQLNHAEYSLTKTLALQKLLKENYRDYRETHYFASSSLECETFYCTIPIMVFPSLKSRLSSNLLNTTFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NKQ8</accession>
    <name>M7NKQ8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease P protein subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02564</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874577.1">
        <property type="nucleotide sequence ID" value="XM_007876386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NKQ8"/>
    <dbReference type="STRING" id="1069680.M7NKQ8"/>
    <dbReference type="GeneID" id="19896256"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02564"/>
    <dbReference type="eggNOG" id="KOG4046">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078577_0_0_1"/>
    <dbReference type="OMA" id="IPKSECV"/>
    <dbReference type="OrthoDB" id="124041at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="entry name" value="Ribonuclease P/MRP, subunit p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00754">
        <property type="entry name" value="RNase_P_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016848">
        <property type="entry name" value="RNase_P/MRP_Rpp29-subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023538">
        <property type="entry name" value="RNP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027081">
        <property type="entry name" value="RNase_P/MRP_p29_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00538">
        <property type="entry name" value="POP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="Rof/RNase P subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR027081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="258" mass="29931" checksum="D5A2EE8347D74671" modified="2013-05-29" version="1">MDPLYQSISSQKDTFSSVISSEKHEYEEDLTLSLLKKGLPDEIAESLYINKVKNKPLLIHPTDRYKNNEQGSDPRNLKRLNYLSKLHHKGRKKKPRPLSSREKKATGIYNISKDACKYNIWIPLHNLWKEYIKEIIGSSSISIISQKLLKADMHGSKLKVVRSRCPSRVGIEGICIKETKKTFVLITEKNQQKVIPKENSVFSIEIEQILNYINEKQDSYEEIDEKHLMVFEIMGSHFIYRAAERIGKKIKSKSILEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLI7</accession>
    <name>M7NLI7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAM192A/Fyv6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02114</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874096.1">
        <property type="nucleotide sequence ID" value="XM_007875905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLI7"/>
    <dbReference type="STRING" id="1069680.M7NLI7"/>
    <dbReference type="GeneID" id="19895808"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02114"/>
    <dbReference type="eggNOG" id="KOG4036">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1175854_0_0_1"/>
    <dbReference type="OMA" id="YSKVTHE"/>
    <dbReference type="OrthoDB" id="75807at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039845">
        <property type="entry name" value="FAM192A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019331">
        <property type="entry name" value="FAM192A/Fyv6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495">
        <property type="entry name" value="NEFA-INTERACTING NUCLEAR PROTEIN NIP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495:SF0">
        <property type="entry name" value="PSME3-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10187">
        <property type="entry name" value="FAM192A_Fyv6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM192A/Fyv6 N-terminal" evidence="4">
        <location>
            <begin position="12"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="160"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="236" mass="27705" checksum="6AC9644F928FA3E6" modified="2013-05-29" version="1">MKRLEGDFPRFTSKRSKEWEEAERRVQAAKNPVENEPQPDHRSLYEKLQANRIIKEEEYQESWKLSNLIRTLDDEEIDFLDRLRREKIQVEKEAKKLVEEGLKVFRRNVLKMGEREQFDQSIQQSIYRSWSATEISKSPEINERPLKKMKEMTLKGVILKKNKNSLSKQNDSESKDQYNIKSAENTGESNNILSNMSPKKNKKAGEFPESVITTSSIETTDQKLIVYTSGSDEREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLI8</accession>
    <name>M7NLI8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Spliceosomal protein DIB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_03502</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DIM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875594.1">
        <property type="nucleotide sequence ID" value="XM_007877403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLI8"/>
    <dbReference type="STRING" id="1069680.M7NLI8"/>
    <dbReference type="GeneID" id="19897189"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03502"/>
    <dbReference type="eggNOG" id="KOG3414">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117348_0_0_1"/>
    <dbReference type="OMA" id="GMYELYD"/>
    <dbReference type="OrthoDB" id="147752at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02954">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000004">
        <property type="entry name" value="Spliceosomal protein DIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF5">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="19565" checksum="11A2AA27668C7D1D" modified="2013-05-29" version="1">MSYFLPHLRTYFFTFFLDLLKLIFDDYRGWHVDQAILSEEERLVVIRFGRDGDEECMRQDEVLYKIAEKVVNFAVIYLVDIDEVPDFKQMYELYDRCTIMFFYRNKHMMIDLGTGNNNKINWALEDKQELIDIFETVYKGARKGRGLVISPKGIIDFFYFVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLK8</accession>
    <name>M7NLK8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_03463</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875553.1">
        <property type="nucleotide sequence ID" value="XM_007877362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLK8"/>
    <dbReference type="STRING" id="1069680.M7NLK8"/>
    <dbReference type="GeneID" id="19897150"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03463"/>
    <dbReference type="eggNOG" id="KOG4347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003538_0_1_1"/>
    <dbReference type="OMA" id="IYMSETQ"/>
    <dbReference type="OrthoDB" id="17687at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000002">
        <property type="entry name" value="TBC1 domain family member 9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="223"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="625"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="819" mass="95370" checksum="C401A175BB9ABB58" modified="2013-05-29" version="1">MLSAIDKIKKKANLLMVDLSFSQNEKFRNLFRLPENEQLQYELTGEITVPDTGNKNMYQGKIYASTSYLCFISNDKKSCSFAFPFSTIRKVERIRTNDYIFILTIFTWHMMKVVISFIGVHHNSEAFCNYLKERLKSSIVSIKMLKPFLLSCFSEHMLMDKKLYQNFPLSTGLGSNPNFGYPGSHKKHKDVNKMRLWKGYLQLYGRNLTLIRFPDFYKLIQIGLPNNLRGEIWELCSGSMLMRWLHVNEYQKLQEKYQGQTNPSMEEIEKDLNRSLPEYPAYQTDEGKDALRRVLTTYSWKNPELGYCQAMNIIVATFLIYTTEEQAYWLLNALCDNLLPGYYSTTMYGTLLDQRVFESLLEKTMPILWMHFSKSDVQLSLISLPWFLSLYINCIPLAFVLRILDCFFLEGPKILFQIGLAILRLNGEKLLTVNDDGSFISILKKYFHTLDKSAYPNSSNLKYKSVTHFQELMICALKEFNIITVELINKQRQKYKNEVLNNIEGFAKRTQLRNLHNTGHLTSAEISIIYDRFYSALFQRRIGLGPVKAYMDYNAFKIFISGITNWPQKDKITDLSDTEKHDINESNHVYETFIKSLFLKWDKSLSGLANLQDIISGIAEFKFLDLMHAIAYFFELYDSDNDGKITKDEILKMSECFLFFMQKETDDTYLKSISNFIKNCFEYAEKSDMFIENTSMPNLSKSDVSNNLALNLTEKLYITLPIFRMIILVDELLENFFAVKFSSLLVITQINKNDIKSNGIRSLVNSLIIDGMRVANEVKKCMEDAQKELDDDIKSYNSHLLLYQKKKKDAKTFKTKGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLS1</accession>
    <name>M7NLS1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_03526</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875618.1">
        <property type="nucleotide sequence ID" value="XM_007877427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLS1"/>
    <dbReference type="STRING" id="1069680.M7NLS1"/>
    <dbReference type="GeneID" id="19897213"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03526"/>
    <dbReference type="eggNOG" id="KOG1556">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027018_3_0_1"/>
    <dbReference type="OMA" id="HAMSIKT"/>
    <dbReference type="OrthoDB" id="10256771at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08062">
        <property type="entry name" value="MPN_RPN7_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000004">
        <property type="entry name" value="26S proteasome regulatory subunit rpn-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033858">
        <property type="entry name" value="MPN_RPN7_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="17"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="310"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="340" mass="38760" checksum="BCA41D7000B03082" modified="2013-05-29" version="1">MPSKVPSEALSWINVQVIIHPLVLLSVVDAFNRVALNTSKRVVGVLLGQKNGKIVNVANSFVVPFEEDDKDPQVWFLDHNYMESMNEMFKKINVREKMIGWYHTGPKLRSSDIEINELFKKYITDPLLVIINVKPQTLGIPTDAYFVVEEIRDDGTTTSKTFVHVSSSIEAEEVEEICVEHLLRDIKNAAVGTLSTRITNQLHSLRGLSQRLNEISQYLGKVLNKSLPINHRILEILQDIFNLIPNLSSFFPDIKMSIQGNGEKYDYNNDLTKAFCVKINDQLMCIYLSSIIRSVMSLHDLIDNKIQNKDRSNGVEVSEDKTDDRNKEQEKKDGLLDDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLY6</accession>
    <name>M7NLY6_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873844.1">
        <property type="nucleotide sequence ID" value="XM_007875653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLY6"/>
    <dbReference type="STRING" id="1069680.M7NLY6"/>
    <dbReference type="GeneID" id="19895564"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01870"/>
    <dbReference type="eggNOG" id="ENOG502QRX2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_290202_0_0_1"/>
    <dbReference type="OrthoDB" id="5382203at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR09683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1055" mass="122451" checksum="4AD8057003763FB1" modified="2013-05-29" version="1">MALLRNISISKLKGVSKPSYISHEAALSVILSSIAEFKNTSFTLSLDFSPKVLELINEFLDYILLVFLKTSKSIEISYLRNAILNELPTQLGVEAISEADAELQTYIENEPLAKDLGFKIHEDVRWDLIDVWKKIRVKCMVYSTLGNQEKDNFPTALWGDELISPSVSIYTTSVLEFVAEYMLLVVGNACHRRLSETKNSYPIIEERDLNEGLKYDRAILSLWNRWKSSDSFLDLMVNDNSFSASSVDTALISPKKDNIFEKKSYNFETNVEDIRYETYINTEKDNSGIDKYSDELEVCKLTHMTEYLNFDNKETFFPAFLKGSYINTHTNKKLLENQKNSQNESFYNIELLEQDNSNEQKSEYKTKMRETEHLYKVNAKKNQQCLPLKKKSIPSFDSGEKVSVDSSVIFGSDIENTVDNHTLEVFNTTLSKSVSREISPEDTSKLNPDIPKTTFLERVSAIDNINQDSIDPFNTNTCEFSDISYKDKNDLLTSEKLFDEIRKLSLTYDQEKSTFSKEKSENHQFFIHNYNVNNTINHNFVSHKNSHSLHDEISPCYRILKSEEKDYNSHGNLIDMKSETSTYMKDQNIDEISSKNINIFFHSTNSDLLLKTSSKTQINSSINKSKHDDFLISEIPALDKYSETIALCQNANYLNSKLSQDKKKNETRSNKNTFDKLVDRNATMKMFLNPEGLREIDFDNEKSFLKAYSQTTDIPNISDSYNTELISRYCNNVKELPTLDFVNTSSIKDKRNKLQPREPTIPKEPTTSSLREFFIETSMNKIHEFSNSKLSTKYSHSLKTFDSDNFNDYTSTSQVSSTFKTQKEMEKEHFRDEDKEDLNRSYSRLYRREESLIEFLRNSEPINADSIKFQESIPLDDKNKVLYRKIQLYKNSSTNFSEDNIFPKNSNYSGTTRSIYVRDSPSKNSYQTPESIEKKKLSLDNMFLDSKEFFSLNFDDKSIFLQNSLNDTNDFINEPKTNNYPPKHISIKKANIEHKESLTDFLKNTSPLNYNKRDSINNSYASKKKKNTLFTWKKHELQKIRKVCPEIRYPTIKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLY7</accession>
    <name>M7NLY7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major surface glycoprotein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_03593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08156.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875687.2">
        <property type="nucleotide sequence ID" value="XM_007877496.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLY7"/>
    <dbReference type="STRING" id="1069680.M7NLY7"/>
    <dbReference type="GeneID" id="19897280"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03593"/>
    <dbReference type="eggNOG" id="KOG3544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010455_0_0_1"/>
    <dbReference type="OrthoDB" id="5415993at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003330">
        <property type="entry name" value="MSG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02349">
        <property type="entry name" value="MSG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="783"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08156.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1113" mass="128290" checksum="4058049C7F2D9AD0" modified="2016-03-16" version="2">MYSNLSNILKLNAYDMFFHTIYIIILIELLSLINSAYGRQNIPLRSKEAEMNSVNSSFEYLVDEESIYALILKTNYNNEAKCKEELEKYCEELKEVDLNLESVDNRVKEICNDRGKLEKKCQDLKTEFTKKLKKIEDKAKQLIDDPKDEDCEEYEAECLFLDQSSPLLSYYCNKMTNECYKKKRQKVADEILFRALKGTVNDTDKCKERIKEVCPILSKESDELMLLCLYPDSTCKKLEKKIDYFCNFLRTELNNNELEEKCHERLGDCYFYGENCNKTKCDEVKKQCEEKGITFKIPGSDFIPIKPKVTLLEEIGLEEVFKRAKDKGIIVGRSGEKKLEDMLLLLSKDEKNKNKKCAKALSVCSTSDYLASELKTLCEDSEKESKCENLMNVTIRCSNFRSKLYTNKLSPYSNNKDAETILRHLLPRSLTEEECIMFESECFYLENICSEILKKTCKNLRAACYRKGQEAILYELSKDQLRGKFNLKSENKSVKECQKEVLKNCRKLKENKEQISRCIKPKQVCLEFSEDISTRSKGLKRNLDMIRDSFTKKECVELKKSCEDLEKDSSLNYWNCITLNIRCKYSEVVEELKNRFLKEKKDTLKNQENCERALKEKCDGMFKKETNLFRISCVLQKETCQSIAKGMESHCHLLKENIENQNILDEKSGKGNETLLERICLLWSPYCDQLMENCPDLLKKESNGNDGVCLKLKEKCKPFREKEHLDDELTYKLKGNLGDNAKCKVALENYCVQWKTGTNDTLKSLCNTNKNMNVENEICKRLLEKIAEKCSTLKTNLEKAEKELQEKEKEYEKVKKETKEAMEKSGIFLSRPKESLDQQSIQANAVNSSVLLSSILPENYLNKLSNAKTKLRVIQKSYVDTETSEVEKEGFNAVVRILELYLEFKEECKVLQLDCDFKKDCPESEEVCKKIEKLCELKPLEIKPSNATIMTTTIEGSLCNVTMATEPGKTTEKTITIIKTMNETATKQRSTITLTRTKIIGEGNFTSLCDINIQETNVSFYTSTLTSTLTSTLTSTLTSTLTSTLISTSIITSTVRLTSIQKCKPTKSMIDSTKETQKEEEKEEKVKLNEGMKMRVPEIVKIILLGVMVIGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NM79</accession>
    <name>M7NM79_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">H/ACA ribonucleoprotein complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Nucleolar protein family A member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_03145</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Common component of the spliceosome and rRNA processing machinery.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875205.1">
        <property type="nucleotide sequence ID" value="XM_007877014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NM79"/>
    <dbReference type="STRING" id="1069680.M7NM79"/>
    <dbReference type="GeneID" id="19896832"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03145"/>
    <dbReference type="eggNOG" id="KOG3167">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084513_1_1_1"/>
    <dbReference type="OMA" id="EDNYEAR"/>
    <dbReference type="OrthoDB" id="5364946at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000015">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit NHP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="10">
        <location>
            <begin position="47"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR08302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="164" mass="18413" checksum="18D242B91F1C1E13" modified="2013-05-29" version="1">MGKSKKEIQTQEKVHSPTNHKKTLSDDYIDSLSPIARPLAPKKLRKRVFKALKKASKVKHIQRGVKEVVKALKRGEKGLVVLAGDISPIDVISHLPVLCEDYSCPYVFVPSKESLGEATNTQRPTSCIMIIPGGKNKDMNTAKNTYMEIYEEILEQVENAHTWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMA6</accession>
    <name>M7NMA6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit G</fullName>
            <shortName evidence="5">eIF3g</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 RNA-binding subunit</fullName>
            <shortName evidence="5">eIF-3 RNA-binding subunit</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Translation initiation factor eIF3 p33 subunit homolog</fullName>
            <shortName evidence="5">eIF3 p33 homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIF35</name>
        <name evidence="8" type="ORF">PNEG_01971</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit G family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873949.1">
        <property type="nucleotide sequence ID" value="XM_007875758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMA6"/>
    <dbReference type="STRING" id="1069680.M7NMA6"/>
    <dbReference type="GeneID" id="19895665"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01971"/>
    <dbReference type="eggNOG" id="KOG0122">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034595_0_0_1"/>
    <dbReference type="OMA" id="ICQGDHF"/>
    <dbReference type="OrthoDB" id="639027at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12933">
        <property type="entry name" value="eIF3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12408">
        <property type="entry name" value="RRM_eIF3G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03006">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017334">
        <property type="entry name" value="eIF3_g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024675">
        <property type="entry name" value="eIF3g_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034240">
        <property type="entry name" value="eIF3G_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12353">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037949">
        <property type="entry name" value="Transl_init_eIF-3_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="212"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="292" mass="33586" checksum="2BED3E44DBCD3E82" modified="2013-05-29" version="1">MSLNDLSVAQTKPLDWADDEYSESSVLPNVFEGSEDIRTVVEYYVENGKKFKITRKIKKIVVKEKDNPAIEERKKWKKFGVEKDRGPGPDPSTTSIGENIVLKFQLGWSKNVYKGLEEDQSVSKTTKDVFKDKKVACRLCKGDHFTARCPYKDTLQPFDEVNNTMNLNISNKSMVSSESSAEATGRYIVPHLRAGRSAGGDSMFRRDKDEYFTVRVTNVSEDAREEDIRELFERFGRISRLYLAKDKETGRGKGFAFISYYDRMDAARAIEKMDKYGYDNLIMRCEFSKPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M7NME8</accession>
    <name>M7NME8_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_02024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874004.1">
        <property type="nucleotide sequence ID" value="XM_007875813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NME8"/>
    <dbReference type="STRING" id="1069680.M7NME8"/>
    <dbReference type="GeneID" id="19895718"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02024"/>
    <dbReference type="HOGENOM" id="CLU_1778274_0_0_1"/>
    <dbReference type="OrthoDB" id="121932at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018607">
        <property type="entry name" value="Ctf8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47475">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47475:SF2">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09696">
        <property type="entry name" value="Ctf8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR09843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="146" mass="17076" checksum="3066838B9470645E" modified="2013-05-29" version="1">MDKKKIYPIALITPPEKNKNIKTSLKDYIPIIMNILGGHELILLEIQGTIERDDTDNTDRHIVPKAIIILYAINMKEQKECIYLKIGYHYLEGKIETLLQPFAVLRRRSKKNIQSNDNESYHDEIIDVLEIIRKRVVFNLLPQPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMN0</accession>
    <name>M7NMN0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SIT4 phosphatase-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873660.1">
        <property type="nucleotide sequence ID" value="XM_007875469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMN0"/>
    <dbReference type="STRING" id="1069680.M7NMN0"/>
    <dbReference type="GeneID" id="19895391"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01697"/>
    <dbReference type="eggNOG" id="KOG2073">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003676_2_0_1"/>
    <dbReference type="OMA" id="ECKSHNP"/>
    <dbReference type="OrthoDB" id="295029at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008287">
        <property type="term" value="C:protein serine/threonine phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905560">
        <property type="term" value="P:negative regulation of kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007587">
        <property type="entry name" value="SAPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634:SF8">
        <property type="entry name" value="FIERY MOUNTAIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634">
        <property type="entry name" value="SIT4 YEAST -ASSOCIATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04499">
        <property type="entry name" value="SAPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="917" mass="106092" checksum="2DA343869D5B830D" modified="2013-05-29" version="1">MFWRLGGFGFASASVIDSLLEKAPDVTLEEILDEEELLQECKSHNPKLIEYLREPDVLRKLLKYIITEDLDEKVKQKYPYIACEVLSCEIWSICETIMENKMLLFEFWEFLERPGPLDPLQASYFSKVNEQFFEKKTEEMILFIQSIPNIVFKILNHIETSAITDLLLKIISIEQNDLGVINWLQNESLIPYLLSKMNPHVDPSTQTAAADLLKEIIAISSSSENQRSIGSNALLRELVSKESIEILVKFMFDTEAPFSSSSLINSTSVIIELIRKNNSDYNRVSFFDISFAKNTSGEKGPIYLGNMLKILASHIPDFQKILLDPRMPKDEIEIAYDKIKPLGIERLRICELYAELLHCSNIILLNKPENGPKIMKKDELCDKTEENLQNTKIAGGSDISENLETYEVFNTEQVFSWENLSFKYIDSNEVLENKEHLLDKNSSIEDIFLEKITKIKSPIPENDFDNYSSELNSKESETNNTLVNHLNNNNNNDLRKEDVESDENLGHFENSYDALNIPLQNNLSDEKYCADINEITVVHDNTDTIFELDVSDYLKIQFIEHKVLSTLLDMFFIFPWNNFLHIVVYDIIQQVFNGPMDEKYCSALAIDLFSQGKICEKIIQGQRDNDNAVSKPCGVRLGYMGHLTLIAEEVIKFTKRYSHTISSIIAEKVLSTQWIDYVEDSLAKTREKDNAILGGIRPHHLSLHSVTDFDDHGLQDFISDVTDIDYDDDDDDDDDLNRRINLFGIQDINDKHSITDMDDDRDLKHDQFSRYINQQSIDKFSNNYGRPDNDKEDISWIEENEAFKNNQITSDLNPSQCQEITDEEFVNKPLNDIFEQKIYNEYQENYIDKNTIVDSFLILGEKQEKIDNNYGNFNNKSDLNSDNHIQDLDYRLLDSITISEQEIQDKYYNTTEKISKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMR1</accession>
    <name>M7NMR1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01732</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873695.1">
        <property type="nucleotide sequence ID" value="XM_007875504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMR1"/>
    <dbReference type="STRING" id="1069680.M7NMR1"/>
    <dbReference type="GeneID" id="19895426"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01732"/>
    <dbReference type="eggNOG" id="KOG0274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_103_3_1"/>
    <dbReference type="OMA" id="TMCRAAQ"/>
    <dbReference type="OrthoDB" id="190105at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22147">
        <property type="entry name" value="F-box_SpPof1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050995">
        <property type="entry name" value="WD-F-box_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604">
        <property type="entry name" value="WD40 REPEAT PF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="385"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="595"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="665"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="719"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="759"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="801"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="841"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="949" mass="108086" checksum="7B1EAAF7774CB676" modified="2013-05-29" version="1">METPLSPDSRQLLSVEDDKTHLIIIPETSSHTYAEHKESKYEGTPAVAQFSLGPITHTTVVTTTTTTTTNFPPIVFYPPKKKKNFDSKQYPLYDAPTPACLKRFCFDIDGRPAYFRESDAPHESLTQLREDMERLEKNNTITITVRENEEHSFKKKDTQVLENEMELPMLQTDSVLAESSYQRIHSNSLVSHEDQAFKTRITRENTSKHIGHESFCSNIEKKCLQNIVDVDPLDISNDDISTKIISNSDLNKNISNGSRNQIPIESNLPSYQFLPLPSPSLSPVITTLNSENEPYFASRNNRLNTTKTVHCKSQKENYEQIDIKEINTFVLSDQGNSIIRIPEILNIFDNLPPNIQTYLIHHLLRRCNKTTLQIVANLVNPTLKRDFLALLPFELAFNILKELDVKSLCRAAQVSKKWKQIVDADEWIWKMRFDADGFKLRDNELDQIVSEDRVLQCTDSNDVSSTHMLKEIKHILHVNSNMYSKKCEKTLNIQNEKHSLAEHGETTEKYFQEVENKESNFIQKQHLFKALYKKHHIIRKNWMNPNIKPRHISFRCHDRNVVTCLQFDADKIITGSDDSSINIYDTLTGRLRRRLQGHEGGVWALQYLGNSLVSGSTDRTVRVWDIAKGECTQIFEGHISTVRCLQILPSTNIEFTHNGIKKQINTSVIVTGSRDSTLRVWRLPQPGEVHYRPSPPSSPNAVNADSTNVSTNPYYIRTLVGHTNSVRAISGYNNILVSGSYDSTVRVWRISTGECIWRLVGHSQKVYSVVIDPKRNRCVSGSMDWKVKIWSLETGTCLWTLEGHSSLVGLLDLSYDYLVSAAADSTLRIWDPDTGKCIHVLSSHTGAITCFQHDENKVISGSDGLLKMWDVRTGRFVANILTDLSGVWQVRFDERRCVAAVQRDHVTYIEVLDFGAAADGVPEEERGRRIIIDNTSLMDDLAQANREAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMR9</accession>
    <name>M7NMR9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BRO domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_03008</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875059.1">
        <property type="nucleotide sequence ID" value="XM_007876868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMR9"/>
    <dbReference type="STRING" id="1069680.M7NMR9"/>
    <dbReference type="GeneID" id="19896695"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03008"/>
    <dbReference type="eggNOG" id="KOG2220">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003661_0_0_1"/>
    <dbReference type="OMA" id="YLKRSYG"/>
    <dbReference type="OrthoDB" id="2141925at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF30">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="7">
        <location>
            <begin position="5"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="466"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="546"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="754" mass="88242" checksum="0FA6FAF21241090C" modified="2013-05-29" version="1">MPQIPYIHFQKKQTEKVDWVEPLKKFIQATSIDENQYINECNILNKLRQDIQEENMDIINLNMLYKYYGQLEFLSLRFPIDEKNIRILFTWYCAFTNTAISQYSLAYEKACVMFNIAATLSTIGTTRDRSKEDEIKKAYHYFQSSAGIFEFINTNFLHAPSFDLEKDNIQSLCEIMLAQAQEVLCEKQINESKKPSIISKLCAQTAWYYENIISKISKNVQKKIFKKYWLQLCEIKQKYYSSIAHLNKALVDEGNNKYGEALAHLAIANTQCREASKLSLSLLLSISTSDKLMFDPMSYFNNIIKNLSMQIQEKKNKLNHDNDYIYYQSIVSEESLKPLERLSMAKATPIQEIYVNQNIQELIGQDIFYKFIPISIHESVSLYSEEKAKLIRKELERCETADLELDIALSHLKLPDSLKHYKYNDSIIVKELSKVPEEIIELSKSILDQEKDCEVLSLINSLLNLKEKINLDLNEVEFIMNEEEQECETMREKYLRKWSQIPSSSLTLLMKKQLSLYRENLSSYADLHSQLISEYNSFAHQIATLIEGEKNIQKNYEREIEKAIQSSQTNLLDFDDSNDIQNEVNKIENILKKLSIIKRERQATLKDLKEKICNDDISNILILKKAKSDTEKQIFLSELEKFKLHETRLSETIYHQAQILRNLTLDFENLQSISSKSPIIQKWTKMTETNKSISNNFKETYKKYCNIRSRILDIISSYKELKNLSSLLLLNTKKFVDDRRHEGANILFHIKATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMU7</accession>
    <name>M7NMU7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_03033</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Phagosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875084.1">
        <property type="nucleotide sequence ID" value="XM_007876893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMU7"/>
    <dbReference type="STRING" id="1069680.M7NMU7"/>
    <dbReference type="GeneID" id="19896720"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03033"/>
    <dbReference type="eggNOG" id="KOG0565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006779_0_0_1"/>
    <dbReference type="OMA" id="WLGCSER"/>
    <dbReference type="OrthoDB" id="7862313at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000132">
        <property type="entry name" value="Inositol polyphosphate 5-phosphatase OCRL-1 isoform b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048869">
        <property type="entry name" value="OCRL-1_2_ASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF300">
        <property type="entry name" value="TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21310">
        <property type="entry name" value="OCRL-like_ASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="685"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="865" mass="100793" checksum="A14BDDDC6F4ACC0A" modified="2013-05-29" version="1">MILSDKGIRESISLFLRPTESLYSFFEVSAYIKEKNSIFNRSYVAIIRHNADSLSGYIESALFLFCVKKPMIFVILKVIEITKGLEIKIKQKDEKRSEFMIEASFNNKELLFSFSKKNILYEFIRDTHKHIQILDNKRLYITNQNFAWLSFYKSYAPNGDEMLSLYDDDFSDSLISLNDYNKSYFSKKIHSYIYKAKNYKKFMNTSEEYWVYERLSLQRSSFIESRDLRIKICTWNVNGKGPIEDLSEWLLYKVCDQCVELYAIGLQEVDLSTEAYLRNDNTKENLWDKAIISVLGDHYEKIVSKQLVGILLFIYAHKIISPSLTSVMTSFVGCGIMGIMGNKGAVAVRLTIWDTVFCFVNSHLAAMKSQVERRNQDFHEICRRLQFYDEDMSKNKKSKSLFDCDHLIWCGDLNYRIDMSIFSVKELLEKNEFDFLLEFDQLNIQKRSNRCFEGFNEEEIKFPPTFKYKIGSSWFDSSEKMRVPSWTDRILWKSNGISVKNYRSYMNNVMSDHKPVSVELDAKIEILLVNNYLKLKDLLTKEYQNSENKRIPMVNISLNFLDFKDVVYLEPKTKVIKIDNIGQVTAEFEFIPKRNDKHICKPWIWPCPRSGIINPGNSCYINLTVFIDNISVSKLNSGEDSLEDILILHLKNGADFFILIQGVFSPTCFGMSLEQLSRLNDSQALPIDKSVTNAWSIPKEILRMTEYLLNNGKNVDDLFFTFGSAPIMAHIRDALNTQNEFKDSILENKSKHNLNVISMAETLLLFLDALPNSVIPISFYNRCLRASFYKKDSIMILDILPSLNANLFIYMVSFMRDLSSNFSLDSFQRILLIFSSILMRSSSDKTEQDLQRQVAFLKWFLTDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN49</accession>
    <name>M7NN49_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_03032</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875083.1">
        <property type="nucleotide sequence ID" value="XM_007876892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN49"/>
    <dbReference type="STRING" id="1069680.M7NN49"/>
    <dbReference type="GeneID" id="19896719"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03032"/>
    <dbReference type="eggNOG" id="KOG0304">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027974_0_1_1"/>
    <dbReference type="OMA" id="IKFMMRA"/>
    <dbReference type="OrthoDB" id="1164111at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000048">
        <property type="entry name" value="CCR4-associated factor 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR08551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="303" mass="34563" checksum="1A2EC3C0E28D9521" modified="2013-05-29" version="1">MGPHVVSQHLISPSMLPVREVWAVNLDSEMAYLRELVECYNFLAMNIEFPGVIARPIGSFLSGSDYYYQMLRCNVDLLKIIQLGITFSDSSGNFPPDACTWQFNFKFSLNDDMYSQDSIELLQKNGIDFKRHEEYGIDVNYFGELLISSGFVLLDCVKWMSFHSSYDFGYLLKIMICNCLPVEENEFYELLHIFFPKLYDIKYIIKFTNTLEGGLQDIADDLRISRTGLGHQAGSGSFLIARVFFELKMNFLKDILDDVKYTGYLYGLENPGQEKGLDAIQATSSSVTNNLASNSHISNKEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN97</accession>
    <name>M7NN97_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF8032 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874917.1">
        <property type="nucleotide sequence ID" value="XM_007876726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN97"/>
    <dbReference type="STRING" id="1069680.M7NN97"/>
    <dbReference type="GeneID" id="19896567"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02880"/>
    <dbReference type="eggNOG" id="ENOG502QY0U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_637964_0_0_1"/>
    <dbReference type="OMA" id="HRYETEC"/>
    <dbReference type="OrthoDB" id="5599902at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058345">
        <property type="entry name" value="DUF8032"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22949:SF0">
        <property type="entry name" value="RE27538P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22949">
        <property type="entry name" value="WHITE COLLAR 2 PROTEIN WC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26087">
        <property type="entry name" value="DUF8032"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8032" evidence="1">
        <location>
            <begin position="139"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8032" evidence="1">
        <location>
            <begin position="303"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="430" mass="50363" checksum="70D602E5F96BC770" modified="2013-05-29" version="1">MEPFHSGVSFLDPSNMNTTKWVSMYHWPITTYAVQDMPDVKWTMHDTHPISTTFQENPHLIPIHDTYLYHPWTSITHSTLGQSMINAGSNMGIHSHPPVYPYGGFYGNEWNTIKKEKNVSSGPIPANPLRIYKDSKGVDWISFAYSRERVRTEYTIRGDVETVDLDTLSEEFKQQNCIYPRARVPPEQYTGTRHRYETECNSIGWALAKLNPCLRNKRGLIQRAVDSWRNKEPSLRSRRVRRMVALNNLHCIREARHVLHASNQESPLPPQFRQVTSTITNRAAPGTLEEKGKSLNTEVKKPKYILLDDMRKKTRVRIRVGLDEINLEEIPDAFRRDHCVFPRRFIPMHTSTEPINTYEQEFQTEEAKKEQMLNEIGWKLAWLNVRLFENRPSFLQRAVDAYRNKIEIVTCEEKWGTRKGRKAWFNKTYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNI1</accession>
    <name>M7NNI1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01517</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat PWP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873458.1">
        <property type="nucleotide sequence ID" value="XM_007875267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNI1"/>
    <dbReference type="STRING" id="1069680.M7NNI1"/>
    <dbReference type="GeneID" id="19895212"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01517"/>
    <dbReference type="eggNOG" id="KOG0291">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010458_0_0_1"/>
    <dbReference type="OMA" id="VYEWQSE"/>
    <dbReference type="OrthoDB" id="3142434at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000920">
        <property type="term" value="P:septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="141"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="185"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="334"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="376"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="462"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="504"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="7">
        <location>
            <begin position="738"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="881" mass="100211" checksum="91E367324640B9EB" modified="2013-05-29" version="1">MKSEFKLCNVLGSFYRNGNLIFTSKNELFSPIGNRVTLFDLEGNTSVTLPFENSKNIRCIALSPACTLLLSVDEDGRAILLNVIKRVVLYHFNFGSIVEDVKFSPCGKYFAVAIGYHVEVWKSPKLSDELEFSPFVKHRVYTGHHDTIKTITWSSDSRFFLTASKDITARLYSLDPMENFTPMTFAGHREALVGAFFYSTEKMIYTASKDGALFYWKESLPSEEIGSMKNQDLNKDFKYKWTIMNKHYFNQNNAKMTCIAFHHKSNLLVAGFTSGIFGLYELPEFNMIHTLSISQNAIDFISINGTGEWIAFGGGKLGQLLVWEWQSESYVFKQQGHFDMITGVVYTPDSQNIVTCSDDGKIKLWDIRSGFSLVTFSEHTSTVTGLGFSKSGNVLFSSSLDGSVRAWDLTRYRNFRIFVAPIRIEFSCLAVEPSGEIVSAGSLTSFDIFIWSVQTGQLVDRLSGHEGPVSSLSFSNTGEILASGSWDKTVRLWEIFTSRQSVELLQLQSDVLAVTFRPDGKYICVSTLDGQLTFWDVDKGNQVNIIDGKKDISGGRNIGDQFSAANSFRNKSFKCVCYSPDGYIVVAGGNSKYICIYDIESSVLIKKIQISKNLSLDGTQEILNSKNFTEAGPLELIDDHDDQDDLQDKADNLLPGATKSDLSIRKLRPEIRTHALGFSPNGRSFAAATTEGLLIYSLDDLHLFDPYYLDIEITPQTIRTVLLKEDYLKAFIMAFRLNEQYIIHEVYESIPFNNIELISRELPLVYLDRLLKFISIITESSPHIEFHLFWIEALFTYHGKYIKSRNQDFIKEIRAIQKYLIYIQHDIIKISDENKYFVEYILNRKKINYQTTSLVKKSDEIHMKDVFDDTHSRTNHINNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNI9</accession>
    <name>M7NNI9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Casein kinase substrate phosphoprotein PP28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875022.1">
        <property type="nucleotide sequence ID" value="XM_007876831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNI9"/>
    <dbReference type="GeneID" id="19896662"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02975"/>
    <dbReference type="eggNOG" id="KOG3375">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084870_1_0_1"/>
    <dbReference type="OrthoDB" id="21120at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019380">
        <property type="entry name" value="Casein_kinase_sb_PP28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039876">
        <property type="entry name" value="HAP28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22055">
        <property type="entry name" value="28 KDA HEAT- AND ACID-STABLE PHOSPHOPROTEIN PDGF-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10252">
        <property type="entry name" value="PP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Casein kinase substrate phosphoprotein PP28" evidence="2">
        <location>
            <begin position="96"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="190" mass="21642" checksum="746FAF5E78451568" modified="2013-05-29" version="1">MTKKKIGKPVRGGASKHSVSGKCFSTELMLNQDGTLQSDITPKTWREIEETSSDTTDSEKNTNDSDISNSEAQSSFHEREKRKSKGAPQPIIEIQNPNRIKKQNYKPSELLKLEPQELSRKDRDAIEKRAAEERYRKLHSEGKTEKARADLARLAIVRKEREEKARQRKAEQEAKETAAQARTGKSLRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNL7</accession>
    <name>M7NNL7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TBP-associated factor 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01533</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873478.1">
        <property type="nucleotide sequence ID" value="XM_007875287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNL7"/>
    <dbReference type="STRING" id="1069680.M7NNL7"/>
    <dbReference type="GeneID" id="19895228"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01533"/>
    <dbReference type="eggNOG" id="KOG2549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021711_3_0_1"/>
    <dbReference type="OMA" id="YFVQFIA"/>
    <dbReference type="OrthoDB" id="361039at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000144">
        <property type="term" value="P:positive regulation of DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22931">
        <property type="entry name" value="HFD_TAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08050">
        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000033">
        <property type="entry name" value="Transcription initiation factor TFIID complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.770:FF:000001">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="8">
        <location>
            <begin position="5"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00076308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="466" mass="53134" checksum="713CB3D2EE3DC8C4" modified="2013-05-29" version="1">MVASVWPPDTVKDVAESIGINQLDDDVAKVLALDIEYRIHEVIQEAIKFMRHAKRTILTVSDISHALRVLNVEPLYGYQAFRPVRFGESRLEQGQPPLYYLEDEDIEFDKVIHAPLPKVPRDINYSVHWLAIEGVQPAIPQNPTLSDTLATDRKDSGTLNNNSWSISNPSSSGIEVKHLVKHVISKELQLYFERINSAILDEQNEGLRSAALTSLRQDSGLHQLLPYFVSLVAEKITHNLKNLFILNMMMQMTWALFDNPNLFIEPYLHQIIPSILTCLVAKKLGENPASKEHYELRDFSSSLLGLICQRFSDVYHTLKPRITRTLLKAFLDNRKPFTTHYGAIIGLITMGKEVIRILILPNIKTYELLIKDDINGPELTIKKMEATKCLEALMNALRTLSKDETSEIKTIDEVFNNEEIIDLSPETQTILVEMVGELMTNKIIEEKDEKIIKTLLEAHKLDKILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNN3</accession>
    <name>M7NNN3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translocation protein SEC62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_02906</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874946.1">
        <property type="nucleotide sequence ID" value="XM_007876755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNN3"/>
    <dbReference type="STRING" id="1069680.M7NNN3"/>
    <dbReference type="GeneID" id="19896593"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02906"/>
    <dbReference type="eggNOG" id="KOG2927">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040936_1_0_1"/>
    <dbReference type="OMA" id="WGWQETK"/>
    <dbReference type="OrthoDB" id="200187at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071256">
        <property type="term" value="C:translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004728">
        <property type="entry name" value="Sec62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011553">
        <property type="entry name" value="Sec62_asco"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00869">
        <property type="entry name" value="sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443:SF9">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03839">
        <property type="entry name" value="Sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR08731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="227" mass="26855" checksum="5BC33B5387D2391F" modified="2013-05-29" version="1">MSPETSEQALTLARLLRHQSLLKHRSGVLNGKRVDFFKAKYIFRFFETSFYVKKAKKTPSLPSIKTEEDVVKTIRLLVDHALIQRVDKLSSRKDRRGVRSYRLQTYASQEEITQDAYYAWLYDFVPMSTFFLGLGTLILILIIIVYPLWPSKMRRIVYYLSWAALGLISLLIVITILRLIFYVITTTFLPPGIWIFPNLYEDVGFVDSFKPIWDWHREKHKKIRKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNX9</accession>
    <name>M7NNX9_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GTP-binding protein ryh1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02743</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874773.1">
        <property type="nucleotide sequence ID" value="XM_007876582.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNX9"/>
    <dbReference type="STRING" id="1069680.M7NNX9"/>
    <dbReference type="GeneID" id="19896434"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02743"/>
    <dbReference type="eggNOG" id="KOG0094">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_10_2_1"/>
    <dbReference type="OMA" id="PVSNDGC"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904515">
        <property type="term" value="P:positive regulation of TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01861">
        <property type="entry name" value="Rab6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000229">
        <property type="entry name" value="Probable Ras-related protein Rab-6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="204" mass="23147" checksum="D642756CA57C67E8" modified="2013-05-29" version="1">MTDLANSLKKFKLVFLGDQSVGKTSLITRFMYDTFDNTYQATIGIDFLSKTMYLEDKTVRLQLWDTAGQERFRSLIPSYIRDSSVAVVVYDITNRNSFINIKDWINDIKSERGNDVIIVIVGNKTDLNSKRQVTTDEGEKMAKDLKTQFMETSAKTGSNVKTLFRNIACVLPGIENIQDTNSTLMIDVNINPRETNVQQSSCQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNZ1</accession>
    <name>M7NNZ1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_02752</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874783.1">
        <property type="nucleotide sequence ID" value="XM_007876592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNZ1"/>
    <dbReference type="STRING" id="1069680.M7NNZ1"/>
    <dbReference type="GeneID" id="19896443"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02752"/>
    <dbReference type="eggNOG" id="KOG0922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_2_3_1"/>
    <dbReference type="OMA" id="MKEVDQV"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17971">
        <property type="entry name" value="DEXHc_DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21691">
        <property type="entry name" value="GH2-like_DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05684">
        <property type="entry name" value="S1_DHX8_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000061">
        <property type="entry name" value="ATP-dependent RNA helicase DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000101">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000191">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044762">
        <property type="entry name" value="DHX8/Prp22_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049588">
        <property type="entry name" value="DHX8_GH2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049621">
        <property type="entry name" value="S1_DHX8_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="196"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="503"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="684"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR08977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1156" mass="131553" checksum="BDCC3075990967FC" modified="2013-05-29" version="1">MDELQKLEKLNLINIITRELVNHVGIEDDNLVEFIIHLHSISDSLNDFKTKLEDAGADFTSSFIENIDRLILLIQPKSVEKNKNTTNNENNDNVSTDDVKSKIFKGLSIPDKEIDWYQVPQTDIHTNNKDFLKLNEPTNNKNEEICINTEKKRRVSHENKNPIYEKDYQHKKHRKINNEVPANNYSKKLDKKPELYKIYSGKVSGIKDFGIFVTLDGVHGKVDGLVHISSIQRGHVNHPSDIVSKFQNVMVKVIKIDQNGRISLSMKDVDQSTGKDLNLSKKVTDRDFLKISGNFPENYQDIPVIEDEDSDYPIKQRKRLNSYERWEIKQLMASGAISAADYPELDDDYNLHINGGDDIEDDEDIDIEVRDEEPPFLAGQTKRSLQLSPIRIVKAPNGSMNRAAMQGEQLAKDRKELRQQEREAASREEFQDLSAQWLDPMAHGEKTFAQDLKNTTLYKKTNDIPDWKKATFSKNTSFGKITNLSITEQRQALPVFKLRTSFVEAIRKNQLIIVVGDTGSGKTTQITQYLAEEGFANNGKIGCTQPRRVAAMSVAKRVAEEVGCRLGQEVGYTIRFEDCTSSKTKIKYMTDGMLQRECLIDPDLKSYSVIILDEAHERTIATDVLFGLLKKSLKRRPDLKLIVTSATLDAEKFSSYFYNCPIFTIPGRTYPVEILYTKEPEKDYLDAALITVMQIHLSEPPGDILLFLTGQEEIDTSCEILYKRVKALGSHVPELIILPVYSTLPSEIQSRIFEPAPPGSRKVVIATNIAETSITIDGIYYVVDPGFVKLNSYDSKLGMDNLVITPISQAQARQRAGRAGRTGPGKCYRLYTEAAYHNEMLPNSIPEIQRQNLAHTIIMLKAMGINDLLHFDFMDPPPVQSMLAALEQLYALGALDNEGLLTRLGRKMADFPMVPSLAKVLIASVEMNCSEEMLSIVAMLSVQTVFYRPKDKQQQADEKKARFHQPEGDHLTLLAVYNSWKSNSFSNAWCYENFIQARSMRKAQDVRQQLLSIFQRYNYDVISCGKNYDRVRRALISGFFSHASKKDAHEGYKTIAEGTPVYIHPSSSIFGKPVEWVIYHELIATTKEYMHCVTSIEPKWLVEEAPAFFKIADQNKISKSKQREKIEPLYNRFATDQDEWRISKQKRIAHTSSTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNZ3</accession>
    <name>M7NNZ3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cohesin loading factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01139</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SCC4/mau-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873053.1">
        <property type="nucleotide sequence ID" value="XM_007874862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNZ3"/>
    <dbReference type="STRING" id="1069680.M7NNZ3"/>
    <dbReference type="GeneID" id="19894836"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01139"/>
    <dbReference type="eggNOG" id="ENOG502RK5N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006541_2_0_1"/>
    <dbReference type="OMA" id="HIQSAMA"/>
    <dbReference type="OrthoDB" id="5565328at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019440">
        <property type="entry name" value="MAU2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21394">
        <property type="entry name" value="MAU2 CHROMATID COHESION FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10345">
        <property type="entry name" value="Cohesin_load"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="595" mass="69293" checksum="F349B6C71B2E7D0F" modified="2013-05-29" version="1">MLSPHIFLWSVAENVFSEAKRIVSFSKEPFPYEEYYKLIATGLGCLETLLCYDKLEVNIEIKTRFRMAEVIFYETEDIQKAEWILSKGVILAQRKNEDIETKFAMQHLQIRIVARKSLKTAQVLLKSCIEEAEERQMVDWIYIFLFLQFDILSYAVNQDSERMGRLSTLMKIICIAENRNDNLVCIVARLFETYLRIETEEYQMAKKCLNYVSAIQTKISNISFLNMIKMMFNIFLNLIQGYGKEAIHELRDLHHELDAFAEETNCLYQDTLNLPLSQNGLNMKIYWFNAQQLFIYGHILSGMCYLPDYSSSKAEVFFNEGLEMLRYDFAYDQFLTNGLRTNKDLDWFEITRQMCLIYYCFALMLRSKFNKAFECIEILEKYSSSFTVITRALFMLLKGTYAQFTGQLDTALKAYESIPVFLHAISLVGSLNSVLIFQGNQLQDKKRVYEILHNIEPLCQSSSFTQLKFAWNLISGSAGKDVLYSKNSLSYVVSASEKHTNTQFRVMALIALCYYFIVHSESEQAEKMLVSAYLLSKNAENDIWAFMSGNLLQELMKKKNKNIKAEKQFQLNLKHKERILDIFNNTNAISINCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPA7</accession>
    <name>M7NPA7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_02707</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874732.1">
        <property type="nucleotide sequence ID" value="XM_007876541.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NPA7"/>
    <dbReference type="GeneID" id="19896398"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02707"/>
    <dbReference type="eggNOG" id="KOG0732">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000536_6_0_1"/>
    <dbReference type="OMA" id="CINILWQ"/>
    <dbReference type="OrthoDB" id="5421at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140674">
        <property type="term" value="F:ATP-dependent histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000219">
        <property type="term" value="P:positive regulation of invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05491">
        <property type="entry name" value="Bromo_TBP7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19517">
        <property type="entry name" value="RecA-like_Yta7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001218">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000016">
        <property type="entry name" value="ATPase family AAA domain-containing protein 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000061">
        <property type="entry name" value="ATPase family, AAA domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045199">
        <property type="entry name" value="ATAD2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069:SF0">
        <property type="entry name" value="TAT-BINDING HOMOLOG 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="415"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="140"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR08926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1296" mass="149219" checksum="21E31727D6635F89" modified="2013-05-29" version="1">MVLTRKRKNYSSDDVNDEHRSRNNVNGLSIRPRVNFINYVETEESIISEKEDIDEDKNEEEEYDEKKCSNIVKLKLPFHRMLNQNNYDKNDVQENSKEKKDTNFDKALNKNGFWNFVSKRPASKLNQNLYKTRSVRQILLEEKKNPSKSSKNKSADSSSEYEYGSDDGFSDDDSESLSSINETSDFITDDSDNSYRRTKKKSRNRRRGGVEKSSRRSKRNSSFDEDGLEYDDDIEEDEIIKELRDLRSPSPHKVNLRQRVSRPDYTIPPPLPTHLPTPKKQNVNGRVTSYKLFSRLGQTSNLHTTTIPSITGDLGVLKDIAESSNSEDELNRVRKFELLGSKSFLSTTCNTDLAGVPSDFGRIKQDLADTDPLGVNQAATFGSIGGLNDFIIQLKEMVSLPLLYPEIFQRFNITPPKGVLFHGPPGTGKTLMARALATSCSNKERKISFFMRKGADCLSKWVGEAERQLRLLFEEAKNSQPSIIFFDEIDGLAPVRSSKQEQIHASIVSTLLALMDGMDSRGQIVVIGATNRPDAVDPALRRPGRFDREFYFSLPDFEARLSIIKIYTKGWDPPLSESFQKQLAEQTKGYGGADLKALCTEAALSAVQRQYPQIYKNSDKLLIDSENIKVEPKDFMSSMKKIIPSSQRSTHLEASSLPDLVVPLLNSKLLEIKEKLSYIMPQNGKVNSLEKAIYEPLEDNSFEYEKFLETFEMSRIFRPRLLIHGKPGMGQQYIGAAVLYHFEGIYVRSFDLASLMEDSTKTPESLIVQYFIEVKRHKPSVIYIPDFQIWYYAVSESVKTTLKMLLTSLKSTEQILFFVVVNDVIGKLDKEALLWLNISEENMVELFAPIKDFRHDFFKKLIDLIKIPPSKIPDDLKKKKKMLKDLPKAPNPPPRVLTKNELKELEYRDRKLKNIVKVKLSPLMEMLKTRYKRFRKPVIDPNEIWYLMTSPKDLSIDITNQPYELVEHNLIHEKATGKKFINMDLELIEEKLWNSIYLSPKQFLHDIKAIMYDANISGDRERLLKAQEMYTNAQMSVEDISDSYFILECRRMIEREKERQKNKILEINKNNILKVENSSNVEKLDENNLVSSVSSMTELSLENTEVNNVITEDDISYDDNIEHMIDFTPIDTIDYKNNENNMNIDFEINKKIDTNTSEKLILKDSDHKFHNLISNISNSLKENPTSINDINKKSSNISQLLQINPDCDSNNEIFNIENIDDTSVFTLILDLSKLNLLLDKMVEMTDSASVEDLEKLYSACINILWQQKNNWNKNDVIDLIEQVFEKTWENIKRPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPB6</accession>
    <name>M7NPB6_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874742.1">
        <property type="nucleotide sequence ID" value="XM_007876551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPB6"/>
    <dbReference type="STRING" id="1069680.M7NPB6"/>
    <dbReference type="GeneID" id="19896408"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02717"/>
    <dbReference type="HOGENOM" id="CLU_568717_0_0_1"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018853">
        <property type="entry name" value="DUF2457"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10446">
        <property type="entry name" value="DUF2457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="219"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="480" mass="55426" checksum="EF22124E7C8196F5" modified="2013-05-29" version="1">MTHIPSTTAEYLTQRLNQLACKEVNQETNNCCKEKRRKNSKSCPGISLLSMFLSSPKASLPEISNVDLLSDHESTSGHSTPTPPLMLRLTPKSNVKFVAPPRKSNVHELVHTLSPILQQPYFPHISQAEPIEDKSQYYVRFTAVQKGENMQAQVSKPSKEELMVFSKINSKKILKNGLIKDEKKSIDISNDLRGGSKPSIKILLENVLPRERLSFVGIEDETDEDYEGLEDEEEKEIQEELEDEEEKEIQEEADHLYKSFYGNQNIEKTNLNNIRNHSFEPASYEEMVATSYDSLKKSSVSLIDCVNQSFEYPPASSRSNNFQDDTDFIFGNLDEDQLVSPKEGSDIRRFTKEFKIVTPHDIDPTFPYSDIEESDSADNSFSDVQHTLYHHSPPFRTKKNKKILSIRSLPGQKEGFHEKEYFKKYFKKSKIHTINIPLHKNNHQKHSENNKNKIKYPYRVKEIKKETNIYNPMDSFYISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPE5</accession>
    <name>M7NPE5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01288</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873212.1">
        <property type="nucleotide sequence ID" value="XM_007875021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPE5"/>
    <dbReference type="STRING" id="1069680.M7NPE5"/>
    <dbReference type="GeneID" id="19894985"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01288"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009666_2_0_1"/>
    <dbReference type="OMA" id="IHHAAIM"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000001">
        <property type="entry name" value="APSES transcription factor (MbpA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF15">
        <property type="entry name" value="TRANSCRIPTION FACTOR MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="6">
        <location>
            <begin position="6"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="239"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="102"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="522"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="574"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="662" mass="75335" checksum="88A639D6ED6CA5C4" modified="2013-05-29" version="1">MSQPKILKTTYSGVPVYEYVVKGIAVMRRYSDSYINATQILKVADFDKPQRTRILEREVQKGEHEKVQGGYGKYQGTWIPLSRALELAQQYKVEDLLKPILDCQPNTKSPPVPKQITSTSKRTPQSTPTQKLLRTPKKHIPTDEDLSSISMDDSVSIETHSTQSNLESEVSAINSELDGGIGNRKRKYTQLQNFNNDKQFNKYSEALLDFFMSSNHQSLPDFLIHCPSDFNANSIIDEEGHTALHWACAMGHLRVVETLLDAGANISTVNLQGQTALMRSVLFTNNYDLKSFPQLMHILQPTIHLSDKFSQTVFHHIASTTTSRSKLLAAKYYAETILNRLSEIQPANEIAQLLDAKDSEGDTALTIFARNGARKCIRVLTNFHASLHIPNNQGRTAEEYIIEYERQRQSLPHRQNSLYLNQQSVDNYNKHYETSKLSAPYSRFMNTHSQPHLSEAAIKATQEILPEIQEKLKLLANAYDAELKDKEAYHTQALELLANMNREIEISRKSLQEIIGTDPNAAEIQKQTIENANKEMEAASKKLRIVIEKNQSRELARLIKEEILAFQYTTKSHENENRKEKERLIYELQNLQKERRKLIDTIVELFAAAGIGERMNEYRKLIAMSCGLNIEDVDNVLDAIEEVLTGNPDDMTEEQAESVVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPF8</accession>
    <name>M7NPF8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Anamorsin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02485</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the anamorsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874494.1">
        <property type="nucleotide sequence ID" value="XM_007876303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPF8"/>
    <dbReference type="STRING" id="1069680.M7NPF8"/>
    <dbReference type="GeneID" id="19896178"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02485"/>
    <dbReference type="eggNOG" id="KOG4020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_918662_0_0_1"/>
    <dbReference type="OrthoDB" id="311633at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03115">
        <property type="entry name" value="Anamorsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007785">
        <property type="entry name" value="Anamorsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046408">
        <property type="entry name" value="CIAPIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273:SF14">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05093">
        <property type="entry name" value="CIAPIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anamorsin C-terminal" evidence="10">
        <location>
            <begin position="207"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site A" evidence="9">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site B" evidence="9">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 1" evidence="9">
        <location>
            <begin position="267"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 2" evidence="9">
        <location>
            <begin position="278"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="303" mass="34999" checksum="DC262F05F4511D99" modified="2013-05-29" version="1">MGSDPEKQDKSLSNTYKDGESLLSSFFPGKIEDFLLTQNKTTQNNILILLPNNFSINKDLSIDTKNYRADICYINDIYTGSKVLEKELYECFFLISTEQKSLNEFILILNPLLMSIKYEKGGRIRIENSERRNQVRQEAILQGWNVNLENEELIFLRPIIPENAVPLPKKKTNLKKNNYNIKFDNIELINEDDLLEPSDLIPPTYENNFCNNQSIKKKKRCKNCTCGLKQDETEITEKIDKMTIHLLKEHELGDIDFIKASNIISNCGNCYLGDAFRCSKCPYFGMPAFKPGEKIQLKLNDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPJ3</accession>
    <name>M7NPJ3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02517</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874527.1">
        <property type="nucleotide sequence ID" value="XM_007876336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPJ3"/>
    <dbReference type="STRING" id="1069680.M7NPJ3"/>
    <dbReference type="GeneID" id="19896209"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02517"/>
    <dbReference type="eggNOG" id="KOG0873">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047036_5_0_1"/>
    <dbReference type="OMA" id="IVHEFIY"/>
    <dbReference type="OrthoDB" id="1658724at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000254">
        <property type="term" value="F:C-4 methylsterol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="5">
        <location>
            <begin position="141"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="296" mass="35219" checksum="694DBB2958436998" modified="2013-05-29" version="1">MSSQVFLNKTLSGSFSNAWNIVGENYSHFSLLERLWTTWYTYMQNNTLATGIMSFAIHEIVYFGRCLPWIIIDFIPYFRRWKLQDQKIPTIKEQWSCTRLVLLSHFTVELPQIWLFHPLTQYFGMSISAPFPNFSKIFFHVLLFFIMEDTFHYWAHRALHWGPLYKHIHKLHHKYSAPFGLAAEYAHPAEVLILGLGTIGSPILWCFLTGDLHLFTVYVWITLRLFQAIDAHSGYDFPWSLNKFIPFWSGAEHHDAHHEIFVNCYSTSFRWWDHFMGTDKRYKALRKRQALKKKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPK9</accession>
    <name>M7NPK9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Triosephosphate isomerase</fullName>
            <ecNumber evidence="6 11">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_02530</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="6 11"/>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874541.1">
        <property type="nucleotide sequence ID" value="XM_007876350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPK9"/>
    <dbReference type="STRING" id="1069680.M7NPK9"/>
    <dbReference type="GeneID" id="19896222"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02530"/>
    <dbReference type="eggNOG" id="KOG1643">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024251_2_0_1"/>
    <dbReference type="OMA" id="NWKMHMT"/>
    <dbReference type="OrthoDB" id="6715177at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000025">
        <property type="entry name" value="Triosephosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF41">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 11 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR09192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="248" mass="27935" checksum="5254096556AF493B" modified="2013-05-29" version="1">MTRKFFVGGNFKANGTIESIKKIVDFLNESELDPNVDVVICPSELYLLYVREHLRDDICVSAQNVYNSPPGPYTGEITVEQLKDAKILWTIVGHSERRIYFNESNQFIALKTKRALENGMSVILCIGENLEERESGRTIDVVTSQLQSVFQYVKCWSNLVIAYEPVWAIGTGKAASPEEAQNVHSEIRQWLKKELGEKSDNIRIIYGGSVTSKNAKELSLMDDIDGFLVGGASLKYEFKDIINIKICT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPU4</accession>
    <name>M7NPU4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SANT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874611.1">
        <property type="nucleotide sequence ID" value="XM_007876420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPU4"/>
    <dbReference type="STRING" id="1069680.M7NPU4"/>
    <dbReference type="GeneID" id="19896288"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02596"/>
    <dbReference type="eggNOG" id="KOG1878">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_377272_0_0_1"/>
    <dbReference type="OrthoDB" id="10258692at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051571">
        <property type="entry name" value="N-CoR_corepressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992">
        <property type="entry name" value="NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992:SF39">
        <property type="entry name" value="SMRTER, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SANT" evidence="2">
        <location>
            <begin position="631"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="735" mass="86371" checksum="2582627BBCB06712" modified="2013-05-29" version="1">MEKKYGKEREYSRNNTCFHDQENIFRNRDERLSVLGSRSLYQNYSLEKRGQRFNSTCPNIIPQGSRYSYFPLYHCGRKKKYLSSFYKHCSEQYSYLPFYHARRNRSSDFEYFSEQVKNNNGIDRSNKYEKDIDRNGYMSDLSKFDSNLTVNNALNKYHDQSFDSYISIGSSKMNGSIKRSMYYKNISKEKGWSRSKDFYKNFTKKFSRFEYEKDDNYRTKTSINDFSLGITKNVLFERNAAKKNDIHGYYNNISTISSGLEDCYFDQVSKDGTSLGGKSENIVFLDDTKLQSPFFPPSSDIVNDINKDDFDSDSRLSFFPDTKELGEIFVKNEENMQELIQKEAQFMDQKAPDFRNTSLDISCAINDSVIFQDSSHQEDNSNLDQKDIHIKIQGINEAILTYEKRFHEIENKLETKVINEDKIFPSKAELPNLLAGNYSSNLETNICSRIYSENKEKAEQNCIKFSYFKISDSSLNGYSFLKENEIRHKRLRPFLLLHISRKNKKIFEKNKVLLLQYQKYQSFWESHVERLDNIKNAKKKDIERYGSLDSHVDSLSLRSFRRGQGLNYGDFVRSDADFEDIIAKLGVEDDRICRAAVIPPMILDPEESVRYKYDDRNRVVDDPISSFHYPTSIDIWTAEEHTLFKELFIKYPQKNFGLIASSIPNKTISQCVLHYYRTKKQENYKSLIMSRNSDRIKKKGRGRSSKKMEKAKVSSLLADLQPRIINDDIDDYEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPX5</accession>
    <name>M7NPX5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sacsin/Nov domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874516.1">
        <property type="nucleotide sequence ID" value="XM_007876325.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NPX5"/>
    <dbReference type="GeneID" id="19896198"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02506"/>
    <dbReference type="eggNOG" id="ENOG502QPMA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001744_1_0_1"/>
    <dbReference type="OMA" id="VYWWVIL"/>
    <dbReference type="OrthoDB" id="10031156at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022155">
        <property type="entry name" value="DUF3684"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058210">
        <property type="entry name" value="SACS/Nov_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12449">
        <property type="entry name" value="DUF3684"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25794">
        <property type="entry name" value="SACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacsin/Nov" evidence="1">
        <location>
            <begin position="27"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1629" mass="188254" checksum="7A46C7C70E0129A5" modified="2013-05-29" version="1">MDISAYKRLTLGEMGRESSVTVNQRSLIDKILARYASEYTLFRELLQNSDDACSRHVEIHYQTLNDPVNYEDMSQMTKRLCCQLVFKNDGVLFREEDWQRISRIAEGNPDEEKIGAFGVGFYSVFSICEDPFVMSGNQTMVFYWKNDQLYVKRAVINAEVPMTTFLLQMREPMEMPYIADLCRFLTTCFSFTRNLLNISLYFDGFRLVSLSKSKELSQLVPIPKELILISPQKIMRIDTVVMESLKIRASYLNFVCWHPKRSGKSILRPKWIDKINPFNHDTYEDMDPNLEITSDITLRIASAMIQVSISPSYKKELERVTKKKPPKSTRVQLLYSDHLGNNVTSRSKIFFSDLLTCHKQGNVYIGFSTHQTTGFGVHLGASALIPTVERENIDLVDKFVKYWNNEILYCFGILARIIYHYEIQRIVDHFQDDIKTSFIYVMNMFTIEASTPLPISNIIEEAFFSCSKFCSVPLIADKVISSDKIYLPDSNIDFLPEMPFISHDVLLESAKFFDKLKYMDMIKQISLDDIYNELSKTALTVQNTLSFIKWLNRKSNIDYIMRLKLIGAVVISDQHLGTINLSYLRCFLNTKLIPPDMPLPPTCAPYVLTRNFSSSELEILDWKELSMLEWLEYICSPSVLSTKNDINHSSQFALRVLEIVSKNWEKMDYADRNDIVILLNSKTCIPTKDHGMRIPSETYFHTVTLFSDLPVIEPMIGVKEAFLSDLGVRKTVKYQVIFDRLIGGGEWSHIDLICYLASSKDSIPSSDFEKLKKTSICKMEGNSIQTYPVCELYEPIDSLRALSLPVIQWSQNKWNPSSNEALLLFSLGLKRFPSPDVLVNLAASGPSELREKALSFFIANYYTYNYESTYSFSKSKLKFLPVQDNNKQTNLESPTTCFTNKFCCVFGFRILRYDLISEAKKFGVQNDPNIDDVVSILIKTPPNTIGLARAQFEYLASRVGELKKPVLEKLNKAKFIPTQKFHKNEISHLSPDLCFIQEDDSVFYNQIFDFVDFGHKANVFLKACGTLSQPSFPQLAELLLKDPKHIFDLVKTPEKYQDILRKLVISSYFHKKTKGIFRDMENKPFLLASRKRKSKMIGNKLFSENQETVEYLLSDASSIFIVDDVVSYNLFSEFILAAPQEDILEDFYQSLGSKRLSSVVREEYKFKGPKKENSESYALRKLFIDRCGLFLHETSTVLLHDRDWLVSNLSVAYLEGIKLQRTLKFKNINHSYEHSVTCALDPELECSVYLTKNWDSYDVAHVLCKMLFQKPAIHDPLLLSSLITTDLDVLQQRGYNIQRILYSQDLKKKEEEEFQKINSKHEIEKEMEKYSVDSELQNISSIKYPGSYPFEDFKDNNSNYDLLNLDKNEMSSSIKKKSEFLEKNNSKDFKMFSKFQKPYGSQNNHEKEHKDFFYENISMLKNFFMKKVKLRNNMHIKRPVDYEQSVVSNLYQAIKACKNSNELSVCSSIEIVDVKEAKEGYCNISHSHNLKFVNRTTDNINVYVSKDIHSGELFIMNNKDNIDLFSSLILKKISAVFGFNASVLNIFYDDDGPTIAFNKNGSIFCNLRHYILLHSKKLVSGNLKDVLAFWFVTIAHELSHNIVSEHGHVHSFYTESFISHYMTKLVKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ34</accession>
    <name>M7NQ34_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major surface glycoprotein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874321.1">
        <property type="nucleotide sequence ID" value="XM_007876130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ34"/>
    <dbReference type="STRING" id="1069680.M7NQ34"/>
    <dbReference type="GeneID" id="19896014"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02321"/>
    <dbReference type="HOGENOM" id="CLU_010455_0_0_1"/>
    <dbReference type="OrthoDB" id="10359233at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003330">
        <property type="entry name" value="MSG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02349">
        <property type="entry name" value="MSG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082422" description="Major surface glycoprotein 2 C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1053"/>
            <end position="1077"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1084" mass="127074" checksum="405525C864D82F72" modified="2013-05-29" version="1">MSSFLFLIFIFVLSVLSKNIDFVKDLNKLELDTRSDSYRAFWIDFNFEYDENIILYLILKKNVFDKNLCKKTLENRCSELLEVIPELKNVCDGELSKKCEELQSLKPIMNNCTEFEIQLTKISFLEKNYCNIYIERCILFENVCPNKISDKCNELREICYKKQHEEIADIALLRVFPNFSIELCESSIQEYCLKLSQESDQLVLRCLKWKSTCQQLMKVSQDINIYLKKEIKSIIKNVSERMYEKDVEDIDKLKKDCHQFLRDCNLYVSDFINYPQNIDKNNELSLLCFQLRKICENSGIIVIFYNLFNPIESDVSLSTKIDLNGLHKKAAESGIIVNKRMGDLRDYHLLALLIHSNIDIENKCKKIVKNNCSSIEYFHKDLEKMCLYYKDNNNDMLNCLVLKSKLRNLCKDLSTKLKKIFHSNNKDKGEFAIRDNYFLVNDEDCKSLLSLCFYIGECCEDQYLDKLMCRNLTSICYHKARLRSSYNFMRNVLRGNIYESSDTMEKSNCINKLINICRNSLHQYRGELLELCLSPKKTCSELIKDTRRKCSLLKKELDINSIQFSLERCDVLESSCEELSEDCITDIGLSCYVFQKYCEELRTRIELKNKLLQEKNNSLSKQLFCVERLNNFCTDMIKEANATFMGLCIQLENTCKAIAFSIMRHCTQFQKNFEKYGILFKIQNKTITFYDCKLWKPYCDMLKNNCQGSSFLQSCSLLNEVCEDYYRTEFIELSLMFELNGYLKEQEICMSDLSKRCNMWNQANNKTFQSLCNTLKNDQGLGLCKKLQVHLQKQCIFLDFNLRNFYVSLLAKEKLYKEKKKKATNSTKEVVGLSNSSLIRNFTEQNNYGIWLNKLYVIAFQDVADLLDTEIQVIKDCNRISSETIFKDDCVDIQDLYKKILEFCDSFRSYISNQSWLFTLPVFSTFTSTSIETSMLTNTDYSIKETITETLTSTESSFTVTHTEILPSTVTHTEILPSTVTHTEIIPSTVAYTESLSSTITYTQFIKGWSTLTEKLTETVTVTITLASLTTFIHKTYFPIESRKNFEASYYNFSYLFILFSFFIIIILCIFNFFLFLHKYFFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ51</accession>
    <name>M7NQ51_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GPI inositol-deacylase</fullName>
            <ecNumber evidence="10">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_00974</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="10"/>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872888.1">
        <property type="nucleotide sequence ID" value="XM_007874697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ51"/>
    <dbReference type="STRING" id="1069680.M7NQ51"/>
    <dbReference type="GeneID" id="19894672"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00974"/>
    <dbReference type="eggNOG" id="KOG3724">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006103_0_0_1"/>
    <dbReference type="OMA" id="WVRNLAV"/>
    <dbReference type="OrthoDB" id="348976at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050185">
        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006505">
        <property type="term" value="P:GPI anchor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000056">
        <property type="entry name" value="GPI inositol-deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056824">
        <property type="entry name" value="PGAP1_TMD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25141">
        <property type="entry name" value="PGAP1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25140">
        <property type="entry name" value="PGAP1_TMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="698"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="745"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="812"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="863"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="927"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="961"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="992"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1020"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="11">
        <location>
            <begin position="122"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase transmembrane" evidence="12">
        <location>
            <begin position="705"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR10828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1057" mass="123704" checksum="1081610AB85D1D8A" modified="2013-05-29" version="1">MSVQKKNKKKQLRKLSYRNMVIFSNKMFLLQLWIFRKICVKYRKKYSISLGIMMIAGFSIVMLIMMSYSFIYLQKDHSTCVIPAMYPSYIRLSGFDKKYIKHGRKYGLYLYKERKTLNVHDFEGIPVLFIPGNAGSYKQVRSLASEAAYQFSVSKLDPSLAEHDSKNLDFFSVDFNNDYTAFHGQTLLDQVEYSNEAVKYILSLYQEAQKRRNNTYGYIPKSVIVIGHSMGGIVIRAMVMMPNYLSGSINTIITLSTPHLLPPILSDRKMKSIYDSVNKFWLQSYFHKNESNPLHAVSLISITGGNLDTMVSSDYCDVSSLIPKSHGFTVFSSSIPMVWTGMDHQAILWCDQLRKVIVKSLFEIIDFKSINQTKPLSSRIDIFKKYYLSPTENSAKKQFLQAPLINPFSGGNIRYTVFSLKKIYILKSFRTISSKSTHVYFLPIFPNNIFNFTTLSLLTDQKTISRNGEQQIDIFLCKNDPSSIKDSNIHKKSMKIDLKTLKCKYSEENIVYLPSKNGLSNSYNHFFTYLEYSNNQFNDYQFISIINKSNNTRNGFLVAEFSNKNVIRVQPEITTTKFLWNRFRIVLDANRSLVSEISIPNIDNSLFTYKLKMNSLACDNLIFSPIIRQYISNSYESKYFVNTTKIDVNFHGTAPFMPPINENNARRGLNIQFWLDPTCNKPLNILISLDLYGTFGKLIVKFWTALIVFMYVIIFLCLRKQFRIYNNYGIFINIRNALKLFMRDTFLTLSIMTSFLFLCLSIFQFSRTINMDDLLNQQLKKKLWVKDTWKLWNINKLFFGYRDSLFLFLGPLFITISLGFTIIFTQITYFLISFIAILCNLLQKRFIKIRYRKKRHFFCSFNFSLKFKQRLIAILSLLSLVAVMVPYQFAYLLACVIQFFTCIKTYLNIQKMGLEKALHYKNFRNYVYSVLILMLLHLPFNIPVLIVWAKKISTNWIIPFSSHHNIFSVLPIITLVEFLANEKMIMQAEPKMAKALDIILLIFSVFLTVYGFYYTYFLHHLVNILSFFLSILHFMPFLPFFQQFIHSFMQQKKLTYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ58</accession>
    <name>M7NQ58_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Isoleucine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PNEG_02342</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874346.1">
        <property type="nucleotide sequence ID" value="XM_007876155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ58"/>
    <dbReference type="STRING" id="1069680.M7NQ58"/>
    <dbReference type="GeneID" id="19896035"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02342"/>
    <dbReference type="eggNOG" id="KOG0434">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_1_0_1"/>
    <dbReference type="OMA" id="EIIVIHK"/>
    <dbReference type="OrthoDB" id="1706657at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00818">
        <property type="entry name" value="IleRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000044">
        <property type="entry name" value="Isoleucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000004">
        <property type="entry name" value="Isoleucyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000023">
        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000050">
        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19302">
        <property type="entry name" value="DUF5915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="14">
        <location>
            <begin position="13"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="15">
        <location>
            <begin position="690"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMR09397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1068" mass="125491" checksum="87695FCC745C8A4E" modified="2013-05-29" version="1">MTNFDVIQEELKVLAFWKEIDAFKTSLQLSKGRKQFSFYDGPPFATGLPHYGHVLASTIKDIVTRYAHNTGHYVDRRFGWDCHGLPVEHEIDKKLGINGKNDVMAIGIEKYNSECRAIVMRYSEEWREKIERLGRWIEFDNDYKTLDTLFMQSVWYIFKKLYEKDRVYRGFKVMPYSTACTTPLSNFEAQQNYKEVSDPSIVVSFPLLEDPSTSLLAWTTTPWTLPSHLNLCVNPDFEYIKIYDEASGENFILLEKCLGILYKDPKNAKFRKLQTIKGVDMKGWKYEPPFYYFYERFKERAFKILLAHYVTSDNGTGIVHQAPAFGEDDYNVAFENGIIDEDFHPPCPLDERGNFTVEVSDFAGMYVKDADKAIQKVLKQKKRLVVQTQIVHSYPFCWRSDTPLLYRVVPSWFLKVKEYTKDMLEALESTRWVPSFVKDKRFINWITSCRDWNISRNRYWGTPIPLWVSDDFEEIVCIGSISELEELSGERNLTDIHRDKIDHITIPSRKGKGVLKRIEEVFDCWFESGSMPYASVYYPFQNSENFMESFPADFIAEGLDQTRGWFYTLLVLGVQLFGIAPFKNVIVNGLVLASDGKKMSKRLKNYPELSIVLDKYGADALRLYLINSPVVRAESLKFKEDGVKEVVAKVIIPWWNSYNFFEMQVKLLKKTHDLNFMYNPVNEASNNVMDMWILSSCQSLISFIKKEMSEYRLYTVVPVLLKLIEDMTNWYIRFNRRRLKGEYGKDDTLTALNVLFDVLYTLCRTMAPFTPFLTEAIYQNLKKYIPKTTEEDVRSIHFISFPDVIEERFQLDVERKFNRMQKVVDLARNLREKKSIGLKVPLKQLVVIHHDEQYLNDIKSVEQYIKEELNIRDLFLSSNEEEYGVRYSLVADWPVLGKKLRKDIVKVKNFLSNVTFEQVKKFMQNKEIIVDDIKLVESDLQVIRVLDFENAMYYQTNTDQDVFIILDTRIYPELKTEYLVREVINRVQRLRKKVGLQVIDDIRMEYVMIDDSIGLEDAIFQHQMLLTKILRRPLEKNQSILHEIDPKQIVREKQDVQGATFMLSLLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQB4</accession>
    <name>M7NQB4_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874410.1">
        <property type="nucleotide sequence ID" value="XM_007876219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQB4"/>
    <dbReference type="GeneID" id="19896097"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02404"/>
    <dbReference type="eggNOG" id="ENOG502RABZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1518503_0_0_1"/>
    <dbReference type="OrthoDB" id="5331396at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849">
        <property type="entry name" value="YALI0E11605P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849:SF1">
        <property type="entry name" value="YALI0E11605P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="177" mass="20307" checksum="9723657604D31D76" modified="2013-05-29" version="1">MQWQRMNWFLNVNQGLIGIEKRLIRGKCSFIYKNIRFYSDIKAPDSPMNMSRPSIVVSSFRGGFLGFFIGTSLASAIGYYYLISEYQYASNTLLLSIEELQHVTDSIIKGVKQVEKIEKDVKKIQDSVITKSELESVQADTKKMFESLNLAQLEANERFSELEMDVAKLSRQARTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQG1</accession>
    <name>M7NQG1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor SLU7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_02281</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLU7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874275.1">
        <property type="nucleotide sequence ID" value="XM_007876084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQG1"/>
    <dbReference type="STRING" id="1069680.M7NQG1"/>
    <dbReference type="GeneID" id="19895974"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02281"/>
    <dbReference type="eggNOG" id="KOG2560">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019317_3_1_1"/>
    <dbReference type="OMA" id="KYAWESQ"/>
    <dbReference type="OrthoDB" id="249612at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030628">
        <property type="term" value="F:pre-mRNA 3'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021715">
        <property type="entry name" value="Slu7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039974">
        <property type="entry name" value="Splicing_factor_SLU7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942">
        <property type="entry name" value="STEP II SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11708">
        <property type="entry name" value="Slu7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor SLU7" evidence="9">
        <location>
            <begin position="151"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR09326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="458" mass="53653" checksum="B92A6E85752ECC0D" modified="2013-05-29" version="1">MASDPNFMPMNIYATTGRNRREERWRQKQLEEGRKAGTIDPELDADGKQVNPHIPQFISKAPWYIDETEGKVSLRHQRLRQDYTTETDQSTVFLRGQRAGPAATKFRKGACENCGAMTHKTKECMERPRKLGARWTGKDIQADEVIYQANMTWDSKRDRWNGYDPREHQKIVEEYEKVEKAQEKARNRKIENISEDGYAAKDDDKYADEANMPGQKFDPHSRISTRNLRIREDTAKYLLNLTETSVNYDPKTRSMRDDPNKISRDNRLMANNEFERSSGEAAEFEKLQVFAWQAEERGKNIHLQANPTQGALYHKQHKEEMNEAKIHSRKNIIAKYGGEEHFNIPSKELLYAQTEYYVEYSKDGKVIKGQEKKISRSNYPEDILVNNHTQIFGSWWHEGQWGYACCHQFFKNSYCTGEVTLSEHHNFKNMQNNLQNNTENEILNEKKQDLSANKRKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQQ4</accession>
    <name>M7NQQ4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial intermediate peptidase</fullName>
            <ecNumber evidence="4">3.4.24.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PNEG_02377</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.</text>
            <dbReference type="EC" id="3.4.24.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.59" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874383.1">
        <property type="nucleotide sequence ID" value="XM_007876192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQQ4"/>
    <dbReference type="STRING" id="1069680.M7NQQ4"/>
    <dbReference type="GeneID" id="19896070"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02377"/>
    <dbReference type="eggNOG" id="KOG2090">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001805_0_0_1"/>
    <dbReference type="OMA" id="ALMFEYM"/>
    <dbReference type="OrthoDB" id="17530at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06457">
        <property type="entry name" value="M3A_MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000055">
        <property type="entry name" value="Related to mitochondrial intermediate peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033851">
        <property type="entry name" value="M3A_MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF79">
        <property type="entry name" value="MITOCHONDRIAL INTERMEDIATE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 14" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="15">
        <location>
            <begin position="269"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMR09436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="746" mass="85384" checksum="2A228A3E7B2D44C4" modified="2013-05-29" version="1">MHRFIGPPMMRVNACFTVRCVSRSLTSLVTPVSELQAVFDRVKPGQSVQCSSLVENKGGLFRNTGLIVSNDLVFLARDAVENAQLLSDDITQRQVQNVEDARRIIKDLDRLSDRLCRVIDLSELLRTVHPDKEFVAAAEETYHYMYDFMNILNTHTGLYKVLTRIIENGNIVKELTEEERVVAKGFHHDFEKSGINLSNEKRKNFVDISSRIALLGRHFFSHYSLKQDYIDIPSYLLNDLPSEVLSMLKRGDGSNLKFPTSGWIYQMGMTLIPDQNVRKRLYISGQESKKSKILNLENLLRERAELAQLVGMESYAELALLDKMMKNQMFVLEFLECLAKNNMPIAKKELEPLLISKRIHLFDSNISFLNAWDKDFYLNLEKKYSTFFEKDSIMSYFSIGTVIQGLSTLFTKLYGLWFVQSEVYPGEIWHPSVRKLDVFSEEGHIGVIYCDLFSRPGKQSGAAHYTVRCSRRIDDDVLVKGETSFEYYNNPVLKSYGKLYQLPIIVLVCDFGQVVDKGPTLLSFSELETLFHEMGHALHSMLGRTDFHNVSGTRCATDFVEFPSVLMEHFASDISITPAFARHAADNSFLSPEYFSSYIKNHFKMQTVETHSQIIMAFLDQQYHTSAPLDKGFDSTKVLHSLQDKWGLFPSVPGTSWQTQFTHLFGYGATYYSYLFDRAIAAKVWKDIFAKNPTSRIAGEKYYKEVLKWGGSRNPWECLASLLNDETLANGGLDAVRKVGHWVFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQY7</accession>
    <name>M7NQY7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02112</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874094.1">
        <property type="nucleotide sequence ID" value="XM_007875903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQY7"/>
    <dbReference type="STRING" id="1069680.M7NQY7"/>
    <dbReference type="GeneID" id="19895806"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02112"/>
    <dbReference type="eggNOG" id="KOG0150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1251308_0_0_1"/>
    <dbReference type="OMA" id="RETDFNE"/>
    <dbReference type="OrthoDB" id="191651at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040023">
        <property type="entry name" value="WBP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173:SF10">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="7">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="40"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="201" mass="23329" checksum="B7BEF533147599A4" modified="2013-05-29" version="1">MTDVWKSVGNYWCKYCKTFVRNDSFTKKKHEASDRHQGSLKRFLRDLDKKKEKEEKEKKAVQKELDRISGVTGLGTRSIDVASPKKITKIQAKKAKSTSYKSTTILPIDIKETIGIVGSWEIVPPEEKKKDLNETENILPSDSLLTISTSVRLREDYEDLRSFKIKEKTLPLEIDEKTTEEDTSDLFKKRKFVTNKNLRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQZ6</accession>
    <name>M7NQZ6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_02122</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874103.1">
        <property type="nucleotide sequence ID" value="XM_007875912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQZ6"/>
    <dbReference type="STRING" id="1069680.M7NQZ6"/>
    <dbReference type="GeneID" id="19895815"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02122"/>
    <dbReference type="eggNOG" id="KOG1375">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015718_1_1_1"/>
    <dbReference type="OMA" id="WVPRSVN"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097435">
        <property type="term" value="P:supramolecular fiber organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000009">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="13">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="14">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR09536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="442" mass="49138" checksum="1E370CDD773239B5" modified="2013-05-29" version="1">MREIVHLQTGQCGNQIGASFWSTISGEHGLDSTGVYQGTSDLQLERMNVYFNEASGGKYVPRSVLIDLEPGTMDAVRSGPFGNLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRREAEACDCLQGFQITHSLGGGTGAGMGTLLISKIREEYPDRMMATFSVVPSPKVSDTVVEPYNATLSVHQLVENSDETFCIDNEALYDICMRTLKLPDPGYGDLNHLVSAVMSGITTCLRFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTSKGSHSFRSLTVPELTQQMFDAKNMMAASDPRHGRYLTVAAIFRGRVSMKEVEDQMHSVQQKNSSYFVEWIPNNVQTALCSIPPRGLKMSSTFIGNSTSIQELFKRVGDQFSAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYEMVGVDDEVELEDEIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NR30</accession>
    <name>M7NR30_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_00771</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872674.1">
        <property type="nucleotide sequence ID" value="XM_007874483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NR30"/>
    <dbReference type="STRING" id="1069680.M7NR30"/>
    <dbReference type="GeneID" id="19894469"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00771"/>
    <dbReference type="eggNOG" id="KOG4155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012350_1_1_1"/>
    <dbReference type="OMA" id="ERLRYMD"/>
    <dbReference type="OrthoDB" id="496at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22881">
        <property type="entry name" value="Mdv1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="248"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="290"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="367"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="474"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="80"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR11178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="589" mass="67571" checksum="508FEE097D9ADBDA" modified="2013-05-29" version="1">MIKDMAYFKKSSFYQYMIPYISIKKYLMNVLYQSESDFCIFRLPDELLYDIPEAKQYLYSLFQGFLVAFDEKNNLAEYEIDQSENHGSTIKNELENLTEQKEKNLTLTELKKKKDNILNNINIINIKKALMSSKIKEIDEKISILNKTKYDLLNKLQKLRRKEAETINTLWDTETKIMDLIELKTSRTIENMNDTEIPETDDLNNSEFMSKSIYDKLNSPKIDSKAIQKDSMCILHEQFKPGSNIKSWKSHTETITAIDFDTPFGMMVTASLDDTVKIWNLLNGEYQGLLEGHNASVKCLQLENNIVATGSMDASIKLWNLQHIESYQAVQSFETFNYLNAKKEENNIHLLPFDTKKVTNDLNIATLESHMDEITALHFIGNVLVSGSSDKTLKQWDLETGKCVQTLDILWATAQCNNYLSSSLDNFKSKLSFKEKGYDFVGAIQCFDAALASGTADGIVRLWDLRSGLIIKTLFGHTAPITCLQFDKHHLITGSIDRSIRIWDLRIGSLYDAFAYNDSVTSLHFDSRRIVVSANEPIIRIYDRIERKHWNCGMLTGSNEPGNIVKRVCHKEGYLISGRQNGTIDIYTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRK5</accession>
    <name>M7NRK5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01926</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873902.1">
        <property type="nucleotide sequence ID" value="XM_007875711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRK5"/>
    <dbReference type="STRING" id="1069680.M7NRK5"/>
    <dbReference type="GeneID" id="19895620"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01926"/>
    <dbReference type="eggNOG" id="KOG1488">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009803_0_0_1"/>
    <dbReference type="OMA" id="QICAHAS"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF48">
        <property type="entry name" value="MEIOTIC COILED-COIL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="399"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="461"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="497"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="609"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="689"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="764" mass="85641" checksum="62C0795BC6839216" modified="2013-05-29" version="1">MRAFSGIENIDEKQGDIIESVILGGQNCWRGKKNELKNEEEYNTNVPCGSDKTFGDSEEEQITQQLSEIMIKNDHITQETDETKKIITSKEQEISLKSAHIGNPTPIMHDHARSISTSTDTSSMISPLTPVDFASSYATFAESAEIARLKAKLKASQRQVQHLEEEVAQSRITAHTIDQVINISGAENYLHKLDVSQLNDFHQCSQTANPQTTSYWPVSYTEDSTPDFESEENITLAFPKRNNNNTWNFIPRSNSPLKNTTTMPLNEIQATARSSPISTQTSSETGMIRPWKVHRASTSISGPPVSGGFNHFALSGRRASTDSNYTSFNNFGSFPNQPPSPAMSAVSTGSSSGIPRLPMAVPSTFNSIQIPNDHQGNIVPGNVAMNQHIWNSNTSIPQSASGYIHSQEPINYRRLLDRNAAYNWQIIVDKIVYCNDQQASIFLQQKLKLAPAEQKHAIIDAIVAQAYPLMLNRFGNFLVQRCFEHGTQEHINGIASAIRGNVLTLSMDAFGCHVVQKAFDNVAEDVKATMVSELLRRIPETVTHRYACHVWQKLFEIRWEGSPPTIMKYVNTALEGMWHDVALGETGSLVVQNIFENCLEEDKRPCIEEVLNKIDIISRGQWGNWVIQHMVEYGSPSDRERALSHILENSVAYSVDQFASKVVEKAIKAGGPDILNQYLAKVTEGRADRPRIPLIDIASDQYGNYLIQHILQHASPAHRDQVSTQIRKHMVSLRGSKYGQKVAFQVERWRSHHHHSSYHGTYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NS12</accession>
    <name>M7NS12_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit 5, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00551</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase delta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872444.1">
        <property type="nucleotide sequence ID" value="XM_007874253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NS12"/>
    <dbReference type="STRING" id="1069680.M7NS12"/>
    <dbReference type="GeneID" id="19894249"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00551"/>
    <dbReference type="eggNOG" id="KOG1662">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085114_0_0_1"/>
    <dbReference type="OMA" id="MVDNIQD"/>
    <dbReference type="OrthoDB" id="1262810at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020781">
        <property type="entry name" value="ATPase_OSCP/d_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="ATP SYNTHASE DELTA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00389">
        <property type="entry name" value="ATPASE_DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="220" mass="24606" checksum="D500FAB94A9B08BC" modified="2013-05-29" version="1">MSFRPLRIKGNISKILVLFRKQAYATTETMHFKAPIQLYGIDGTYATALYNAASKNMSLEKIEKSLNSLCNVIDKDVKLSLILNNPSLSLKDRLIIADVLSKLLGNDKLISNFLQIIAEKNRFNFIKSVSKKFSYLITTKRGEIEVVVTSASLLDSHSLKRLETAISKSKYVGPEKKLIMINKINKNIIGGIIVEIGNYTIDLSVADKILKLNKILTDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NS36</accession>
    <name>M7NS36_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00012</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871863.1">
        <property type="nucleotide sequence ID" value="XM_007873672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NS36"/>
    <dbReference type="STRING" id="1069680.M7NS36"/>
    <dbReference type="GeneID" id="19893710"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00012"/>
    <dbReference type="eggNOG" id="KOG3771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025518_0_1_1"/>
    <dbReference type="OMA" id="QEYDYYN"/>
    <dbReference type="OrthoDB" id="2159336at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060988">
        <property type="term" value="P:lipid tube assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072741">
        <property type="term" value="P:protein localization to cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07599">
        <property type="entry name" value="BAR_Rvs167p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000048">
        <property type="entry name" value="BAR adaptor protein RVS167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000100">
        <property type="entry name" value="SH3 domain-containing YSC84-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF1">
        <property type="entry name" value="REDUCED VIABILITY UPON STARVATION PROTEIN 167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="5">
        <location>
            <begin position="17"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="359"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR11568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="48693" checksum="025918428108AFE4" modified="2013-05-29" version="1">MSWKGFQKAVVRAPQQFKGKLNIGENTVDAAYTDVETQFKELEQKLRKLFNNTKKYVQSITDILNYQMEFAGIIEEIYKPITGKATEVENKSHEECSEAVEACQKYQTIVKELQETLTPELEMIESRIIGPTNELLSIISSIHKITEKRERKRLDYDRHRSNLKKLQDKKEKTLKDERALYSAENVVEHSTQEFEYYNTLLKEELPILFDLETNFIQPLFQNFYYIQLNIYYTLYEKMKRIDIGYFDLNTEIVEGFELKRNNIQEITEGLGIVKFTMSRRSRCISEFDNSKPTKLSPTLSHLESNTQSEELPSYYEVQNLRSYQSNCGNNIGESSNVNNKYSNIKKMPPPLPSKPTVLKGRQCAVALYDYEAQVEGDLSFKVGDRIEIIKRTENKNDWWTGKLNGVQGIFPGNYTVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NS56</accession>
    <name>M7NS56_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">VLRF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_01709</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The VLRF1 domain mediates binding to the 60S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ANKZF1/VMS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873673.1">
        <property type="nucleotide sequence ID" value="XM_007875482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NS56"/>
    <dbReference type="STRING" id="1069680.M7NS56"/>
    <dbReference type="GeneID" id="19895403"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01709"/>
    <dbReference type="eggNOG" id="KOG2505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014293_1_1_1"/>
    <dbReference type="OMA" id="AQKTIHR"/>
    <dbReference type="OrthoDB" id="429841at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047139">
        <property type="entry name" value="ANKZ1/VMS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041175">
        <property type="entry name" value="VLRF1/Vms1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036">
        <property type="entry name" value="ANKYRIN REPEAT AND ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036:SF2">
        <property type="entry name" value="TRNA ENDONUCLEASE ANKZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18826">
        <property type="entry name" value="bVLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52044">
        <property type="entry name" value="VLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VLRF1" evidence="14">
        <location>
            <begin position="70"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="306"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="445"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="382"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="450"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR09951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="474" mass="54488" checksum="88B56F3E4A6AD473" modified="2013-05-29" version="1">MEQLFVSKAEKFIEEKSVESQKTKDPIIWTTSTKLKKSLHIGFYRSLFDYDSSQTFISVLRENQLNIKNKNRTIALIMVGGGNFAGMIVSLYPKTENYKNYFKMDELNVLHHKTFHRYTTRRKQGGSQSTCDSGKGAVISAGSNLRRYNEAALQTEIRQLLTSWKHALDKSELIFVRASGKLSHKILFGYENSVLSITDKRLKKIPFTTRRATKNELIRCFNELTMAKIADIDMEEIEVIPETQITNLTNISKTIVADKEFEIQKKNTSQIIFLIKKGNPQKLIDYIEKNALSYDFQFQPISFYQHISTPLHLSSSLSLSFIVITLLEKGANPTIRNGNGKTAYDIAGNKTTQYAFRLCRASLGEERWDWGLAHVASPLTENEIKKREAQSKELKIKTLQEKQRQKEELKKLIETSPPKNLDTEIIKKKSIISLSLEKTLQDQRNLSPDIQKRIEREKRARAAEERIKKSKLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>M7NS97</accession>
    <name>M7NS97_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="8">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_00067</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="8"/>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871923.1">
        <property type="nucleotide sequence ID" value="XM_007873732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NS97"/>
    <dbReference type="STRING" id="1069680.M7NS97"/>
    <dbReference type="GeneID" id="19893765"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00067"/>
    <dbReference type="eggNOG" id="KOG0169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002738_1_0_1"/>
    <dbReference type="OMA" id="HWQREMS"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16207">
        <property type="entry name" value="EFh_ScPlc1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13360">
        <property type="entry name" value="PH_PLC_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08598">
        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000039">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037755">
        <property type="entry name" value="Plc1_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015359">
        <property type="entry name" value="PLC_EF-hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09279">
        <property type="entry name" value="EF-hand_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="304"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="10">
        <location>
            <begin position="612"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="727"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00059664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR11628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="877" mass="103241" checksum="0D4605A943A0A4A0" modified="2013-05-29" version="1">MLDKNYLFYKEIEENKGKNLLTALSKLRSFDMYDQNGRTLDYRLFKKSKFIFFDCDEKQSNYNTLLMQSLTLDCGFFEESKCIKENLGFYNFIVVLFQSLFLQKKLKNYLSENLLSDSFTGPIVSRARFLYTMNLSTELLDLMFFSLKYKEQGTIMFKVTRKKKRKIIFSLNCESGLITFDGKSCKTFSVDDIQDIRIGLDSRNYREQLKVEMDYEDRWFSIIYLTDHKLKILHLIAPTHELRQQWLILLKKIQLYRIEIMGKLGLMGKKSDNWLEKHWELIQKNHSFHFYDIEKLCKKLHVNASKKYLRNLFSKVDILLTGKLDFTQFQKFVKLLKERQEINDIFRTYTRSHRHFLNFEEFQSFLINEQGLDNDPNNKEIFKEYSDKHNNLMSVDDFAEFLFSDKNPLIINSNIDMSRPLNEYYISSSHNTYLLGKQFGGESSIEAYIKVLQKGCRCIEIDCWDGPDGPLVYHGRCFTTKILFYDVISTISKYAFIVSPYPLILSLEVHCSFSQQSLMVSILKELLGEMLITSPTNKNSQVLPSPMELKYKILLKVKQNPENNLNIFGLDTSSSTTTDTTCSSDIDMDNINTEKCKTKSHKKNSGKIIDSLLNLSVYIKGIKFRNFSLPESKTITHIFSLSEKSFSNLIKTSRFQLEKHNVKYLMRLYPNFTRINSTNFEPQQYWQKGVQMVALNWQTNDLGIQINDAMFSGNDKYGYILKPSYLRMTDVKHNEFSIFGLKKILLDIKIISAQQLPRTKDFREDISLNPFVEIKLIMLNNEHKSWKTSTIYDNGYKPIWNETFTVMIDRFQYDFIFIQFNVYNNNSSYSLDNILIATYCLRLSSSLQGYKHIPLNDQYGEKYLFSTLFINLKCKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSC0</accession>
    <name>M7NSC0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873738.1">
        <property type="nucleotide sequence ID" value="XM_007875547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSC0"/>
    <dbReference type="GeneID" id="19895465"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01771"/>
    <dbReference type="HOGENOM" id="CLU_1300161_0_0_1"/>
    <dbReference type="OrthoDB" id="3599883at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024368">
        <property type="entry name" value="Ecl1/2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12855">
        <property type="entry name" value="Ecl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="212" mass="23986" checksum="6A7E1608F999F140" modified="2013-05-29" version="1">MEIGYVFPQYCTVCDQQIENPYSLLLYCSDECKKKDSEDDCREALSFSYKNSFSGSTTVSPSSSFTTMPHLSCTNMIFECVYRPRYASMSRLCSLSDSEEINEYGSPVKYVPSTVPASLINYKSNSHKPKSPIYRMNSFSSLSVRSIELVTPVVLSVKNQDIVNKDRYSQIKGLRYPTKPAGSIYNTDGPGTGIRKLFCFEKSPYTDDFHEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSL2</accession>
    <name>M7NSL2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Type 1 phosphatases regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the YPI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873325.1">
        <property type="nucleotide sequence ID" value="XM_007875134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSL2"/>
    <dbReference type="STRING" id="1069680.M7NSL2"/>
    <dbReference type="GeneID" id="19895087"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01390"/>
    <dbReference type="eggNOG" id="KOG4102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098333_0_1_1"/>
    <dbReference type="OrthoDB" id="307488at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="142" mass="16276" checksum="D3260F3107DF79F2" modified="2013-05-29" version="1">MHQQNLFSRNRSELSQSITEPLVFQSSFTSDQNNEVTGIIRLTGASSERRVRFDETAIDNEGMGKKKSKICCIYHKPREYDESSSSDTDSSSGSENYKNLDTNNHTCFHEDTQVNSGNLQLFDKTNRHLNAYETYPKTRKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTG8</accession>
    <name>M7NTG8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar GTP-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_01282</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873206.1">
        <property type="nucleotide sequence ID" value="XM_007875015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTG8"/>
    <dbReference type="STRING" id="1069680.M7NTG8"/>
    <dbReference type="GeneID" id="19894979"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01282"/>
    <dbReference type="eggNOG" id="KOG1490">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011784_4_1_1"/>
    <dbReference type="OMA" id="EWKNDVM"/>
    <dbReference type="OrthoDB" id="415015at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01897">
        <property type="entry name" value="NOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000496">
        <property type="entry name" value="Nucleolar GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024926">
        <property type="entry name" value="NOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041623">
        <property type="entry name" value="NOG1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010674">
        <property type="entry name" value="NOG1_Rossman_fold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012973">
        <property type="entry name" value="NOG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45759">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06858">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17835">
        <property type="entry name" value="NOG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08155">
        <property type="entry name" value="NOGCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038919">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="OBG-type G" evidence="9">
        <location>
            <begin position="166"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="609"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="614"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR10577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="634" mass="73662" checksum="53DABF1733460BC6" modified="2013-05-29" version="1">MHFKSIAPIPSSKEFLDIVLSKTQRKTPTVIRPGFKISRIRSFYTRKVTFTKDTLEKKLQDILDEFPRLDDLHPFYADLLNVLYDKDHFKIALSHIATAKHLINTVAREYVRLLKYGDSLYRCKQLKRAALGRMATILRRQSQVLTYLEQVRQHLARLPSIEPNTRTLLICGLPNVGKSSFMNKITRADVEEAPYPFTTKSLFVGHMDYKYLRWQVIDTPGILDHPLEDMNTIEMQSVTALAHLRACILYFIDLSEHCGYPLESQVKLYHSLKPLFSNKVTMIIINKIDLMHPNNLDEKSKALLQSILDDENVQMVETSCVTEEGVMNVRNICCDKLLESRIEEKLKDKKADNIMNRIHLAKPIIRDNIERLPIIPDGLKDRKPYDWNDPNRRKLEKDIEMEHGGPGVYNIDLKKNYILENPEWKLDIVPELFNGKNIYDFIDPNIETKLAELEEEEKRLEQEGFYDSDEEIKNEEDIKILEKAKFLKERNDSIKRKAKSKKALNNRAILPRTIGLKSVSEMSKHLTSIGLDTSFIHERLNSHSKKISSSKQLNEDIKMKNVSNESYSRVPNKNRNSNGIADPLTRSKAEKLARLYQRKLKHLAMASESDRRVFNKKPKHLFSGKRKAGKTDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NU18</accession>
    <name>M7NU18_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U three protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01319</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873245.1">
        <property type="nucleotide sequence ID" value="XM_007875054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NU18"/>
    <dbReference type="STRING" id="1069680.M7NU18"/>
    <dbReference type="GeneID" id="19895016"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01319"/>
    <dbReference type="eggNOG" id="KOG1272">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022996_1_1_1"/>
    <dbReference type="OMA" id="EFLPYHW"/>
    <dbReference type="OrthoDB" id="10251154at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000378">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012952">
        <property type="entry name" value="BING4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040315">
        <property type="entry name" value="WDR46/Utp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085">
        <property type="entry name" value="WD-REPEAT PROTEIN BING4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08149">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01033">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="247"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="BING4 C-terminal" evidence="10">
        <location>
            <begin position="328"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="421"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR10616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="512" mass="59369" checksum="B34416F8BF10B16E" modified="2013-05-29" version="1">MDNLKKTNNISLKNKKDRRLLHDLKNMDKKIKSVRKDIEMFNMMKYDEPGYVEGEGLEKTYKITQSQLKEKIDISSRQKGFDLRLPTFGPYVFDYTRNGKNILLGGRKGHIASFDWKKGKLNTEFNLRETVRDVKWLHNEKLFVVAQKKYVYMYDNKGIEVHCLKRHIDVLYMEFLPYHYLLTTIGNAGYLKYQDISTGTIVTEYSTKLGLPKAMTQNPYNAIIHVGHSNGTVTLWSPNLSTPLVKILSHRGPITALSIDREGRYMVSSGADSQVKIWDIRNWKEVHSYFSRTPASTLHISDTGMLAIGWGPHISFWKDALRKKQNSPYLTHLNPGSAVKRVRFCPYEDILGFSHIKGFSNLIIPGSGEPSYDAYEINPYETKKQRREKEVRSLLEKLHPEMIALEPNYIGKVDIVHSTSKENDSLKESKPPEQKWVPKPKTRGKNSSLRRYLRKKAKNIIDERKLRIQASLDKEKKLRQIHLRKRLNLPLEKPLGPALERFSLKSNTYSCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUA5</accession>
    <name>M7NUA5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PNEG_00842</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Golgi apparatus membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Cytoplasmic vesicle</location>
            <location evidence="13">COPI-coated vesicle membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the COPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872751.1">
        <property type="nucleotide sequence ID" value="XM_007874560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUA5"/>
    <dbReference type="STRING" id="1069680.M7NUA5"/>
    <dbReference type="GeneID" id="19894540"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00842"/>
    <dbReference type="eggNOG" id="KOG1078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010353_2_0_1"/>
    <dbReference type="OMA" id="DFIEDCE"/>
    <dbReference type="OrthoDB" id="1074925at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000071">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1480:FF:000001">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000008">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1480">
        <property type="entry name" value="Coatomer, gamma subunit, appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032154">
        <property type="entry name" value="Coatomer_g_Cpla"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017106">
        <property type="entry name" value="Coatomer_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013040">
        <property type="entry name" value="Coatomer_gsu_app_Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037067">
        <property type="entry name" value="Coatomer_gsu_app_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261:SF0">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16381">
        <property type="entry name" value="Coatomer_g_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08752">
        <property type="entry name" value="COP-gamma_platf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037093">
        <property type="entry name" value="Coatomer_gamma_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="14">
        <location>
            <begin position="20"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer gamma subunit appendage Ig-like subdomain" evidence="15">
        <location>
            <begin position="650"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer subunit gamma C-terminal" evidence="16">
        <location>
            <begin position="799"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR037093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMR10691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="912" mass="103440" checksum="F1C1D4F7E9345742" modified="2013-05-29" version="1">MSFSKKDEDSEHIFHHIDKTAVLQEARIFNKSPINPRVCRLLLMKIAYLLHTGDHFAMRDATELFFGITKLFQHKDEALRQMVYVIIKELARTAEIIIMITSSVIKDTTVNLDAIYRPNAIRSLSRIVDATTVPTVERIIKTAIIDKTPSVSSAGLISSYHLFSIAKDIVRKWANEIFEALSLKPAVNLSIIPYLTSVNNRQNQSFITQYHALGLLYLIRNHDRMAVMKMVQRFCNYYNKGSSYGNIQLKSNLAVILLVRYIAKVIEDDQSQRYNMLKLLEEFLHYKNDMVNIEAAKIILQMRDVTEDESLPAITTLRVFLSSPRTVCRFSAIRILNRFAMTKPHLVGCCNSDIESLISYTNKSIATFAITTLLKTGNEVNIDKLMKQIQGFMSDITDEFKIIVIDAIRSLCLKFPSKQAVMLSFLNNALRDEGGYDFKNSVVETLFDMIKFIPESKEDALSSLCEFIEDCEFTKLTIRILHMLGIEGPRINQSTKYIRYIYNRIVLENALVRAAAVSALSKFGQGLNNSDLKISIKTLLKRCLEDSDDEVRDRAVLNIKFLEDDSISDIFKNNNAFSFSALEYQLVSYISSNSFEKQFDISSIPIISKEEMDSESYRQKIAELESLSTLTEATQQLSLVNSFSEDVISQYSNILQSISEFKDYGPLLKSTLKPIELTESGIEYSITAVKHIFKEHIVLQFNLLNTLSDAILENISMVSEPDDPSLKEEFIIQAPKAEHNSSVSIYVSFLRENPDFFVTTTFTNVLKFITKEIDPSTGEPEKVGYDDEYQIEALELSPGDYISPIYINNFTQLWDSLTDKNEVVETFSLSSITSLQDACYRISEQLSMQPIEGTDNVTNSFFHIMKLSGKSTNGITILAVAKLVFSKNEITLKLSVRSENKLVATLATNGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>M7NV28</accession>
    <name>M7NV28_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_00584</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR10981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872479.1">
        <property type="nucleotide sequence ID" value="XM_007874288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NV28"/>
    <dbReference type="STRING" id="1069680.M7NV28"/>
    <dbReference type="GeneID" id="19894282"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00584"/>
    <dbReference type="eggNOG" id="KOG0605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_67_4_1"/>
    <dbReference type="OMA" id="KLRVDQF"/>
    <dbReference type="OrthoDB" id="18472at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035974">
        <property type="term" value="C:meiotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120105">
        <property type="term" value="C:mitotic actomyosin contractile ring, intermediate layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034973">
        <property type="term" value="C:Sid2-Mob1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044878">
        <property type="term" value="P:mitotic cytokinesis checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903501">
        <property type="term" value="P:positive regulation of mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903473">
        <property type="term" value="P:positive regulation of mitotic actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902846">
        <property type="term" value="P:positive regulation of mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902854">
        <property type="term" value="P:positive regulation of nuclear migration during mitotic telophase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905758">
        <property type="term" value="P:positive regulation of primary cell septum biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031028">
        <property type="term" value="P:septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21776">
        <property type="entry name" value="MobB_Sid2p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05600">
        <property type="entry name" value="STKc_Sid2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000141">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000319">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000109">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF417">
        <property type="entry name" value="CELL CYCLE PROTEIN KINASE DBF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="221"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="519"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR10981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="620" mass="72113" checksum="B8B8005509585EB6" modified="2013-05-29" version="1">MSGIQENYEGSPTLNGSSQLPLLSSSASKGHLNTNSLHSRNSRSGLVAVPENFTKNLQGLPDRLGNLHFKKAGKENEGQIDFSLESKDSTSLKGISRSPEKNGMKEAKIQGIQKTEASNSEFQTWNTHKKLTSNEMEKITKPSVKRLVNVCQIFFLDHYFDKLRYLCERQQRIEKFHEWARKQIEEGKLTASEYTAAWKCHCHTERSTLRKRRAKMKQENFHIIAQIGQGGYGSVHLAQMKDTKEIVALKKMSKKLLHKLDEIRHVLTERDILTNSTSPWLVRLLYAFQDPDYLFFAMEYVPGGDFRSLLCNSGILRDEHAKFYLSEMFMSVDSLHRLGYIHRDLKPENFLIDSKGHIKLTDFGLASGIINSQKIESLRLKLDQIKDLEVPTRTAVERRNIHRTLKMQELNYANSIVGSPDYMAPEILNGHDYDFTVDYWSLGCILFECLTGYPPFSGKNMNETWSNLKNWKYTLVRPVYEEKEFNIHDDAWEIITKLITNPRRRISSIQEVKEQKYFKHIDWTTLRQQEAPFVPDLDSEFDHGYFDDFTNENDMLKYKEVYEKQSSVESMEDRLEKVPPTTFVGFTYKHQKIIESNHIQDIPTSVDKLRNREVTFETLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVD0</accession>
    <name>M7NVD0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_00272</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + 3 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872144.1">
        <property type="nucleotide sequence ID" value="XM_007873953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVD0"/>
    <dbReference type="STRING" id="1069680.M7NVD0"/>
    <dbReference type="GeneID" id="19893970"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00272"/>
    <dbReference type="eggNOG" id="KOG1606">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055352_1_0_1"/>
    <dbReference type="OMA" id="RYANRGW"/>
    <dbReference type="OrthoDB" id="1660966at2759"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000001">
        <property type="entry name" value="Pyridoxine biosynthesis protein PDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003215">
        <property type="entry name" value="PRK04180.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00343">
        <property type="entry name" value="pyridoxal 5'-phosphate synthase lyase subunit PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="PdxS/SNZ N-terminal" evidence="11">
        <location>
            <begin position="20"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="8">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="245"/>
            <end position="246"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR11242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="304" mass="32787" checksum="B3CAAC0987A6C86E" modified="2013-05-29" version="1">MTSKFEETGLKEEFSCASFGVKVGLAQMLKGGVIMDVVNVEQARIAEEAGACAVMALERVPSDMRNYRVSRMSDPEMIKKIMAAVTIPVMAKSRIGHFVEAQILEAIGVDFIDESEVLTPADDYHINKHEFSVPFVCGSRNLGEALRRISEGAAMIRTKGEAGTGDIIEAVRHARCTNSSIKKASTLSDQELFVMAKEIQAPYELLKKTAILGRLPVVNFAAGGIATPADAALMMQLGCDGVFVGSGIFKSENPLKRACAIVQAVTHYKDTKKLGEISMGLGEAMIGISCMSITDDQKFSKRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVD5</accession>
    <name>M7NVD5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00278</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872149.1">
        <property type="nucleotide sequence ID" value="XM_007873958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVD5"/>
    <dbReference type="STRING" id="1069680.M7NVD5"/>
    <dbReference type="GeneID" id="19893976"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00278"/>
    <dbReference type="eggNOG" id="KOG1466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_0_2_1"/>
    <dbReference type="OMA" id="GDWESCK"/>
    <dbReference type="OrthoDB" id="10249309at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900036">
        <property type="term" value="P:positive regulation of cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1070">
        <property type="entry name" value="Translation initiation factor eIF-2B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051501">
        <property type="entry name" value="eIF2B_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042528">
        <property type="entry name" value="elF-2B_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="350" mass="38993" checksum="7298A7705184C109" modified="2013-05-29" version="1">MNYTEPDIFDNYSNDTKETLKELSEDKFDIVERYEAILEEDPNITMPIAAIEALVDLVRHTKVNTLSEFTKIIQEGSLILKSSVVNYISVSAGCDLFLRFVTRSLNDADVESCKHHLVSNGKLFVERARKCRDKIASIGAKFIRDGIVILVHSYSRNVNALLLEAASKNIRFSVYITESRPTGSGIITSRILSEAGIPTAIVLDSAVGFLIQKIDLVLVGAEGIVENGGLINHIGTSQIATLAKVAHKPFYAVAESHKFVRMFILSQFDLPTSGPILQFLDQKYPSVPKLNSRQSSLNIHRVNELKMTEEEISNNPILDFTAPEYIDALITDLGILDPNRVSEELIKLYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVI9</accession>
    <name>M7NVI9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UNC-45/Cro1/She4 central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00756</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872658.1">
        <property type="nucleotide sequence ID" value="XM_007874467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVI9"/>
    <dbReference type="STRING" id="1069680.M7NVI9"/>
    <dbReference type="GeneID" id="19894454"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00756"/>
    <dbReference type="eggNOG" id="KOG4151">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_338612_0_0_1"/>
    <dbReference type="OMA" id="VCNLMTC"/>
    <dbReference type="OrthoDB" id="5574718at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024660">
        <property type="entry name" value="UCS_central_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994:SF1">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11701">
        <property type="entry name" value="UNC45-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UNC-45/Cro1/She4 central" evidence="3">
        <location>
            <begin position="259"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR11161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="840" mass="97185" checksum="8C7A819CE8B85B0D" modified="2013-05-29" version="1">MGLMFEELEEISKNIEKSIDSRKKVDLLIRKSKLYLKLKKVEEAVNILLEGFYISPDNEEIRILLNELNKEFEGVLIFSFDFIKAILLNNSRKCQDQEIFNYFLGPNQDLRVKKFIENKGIFELMEGFSKSLYILHFYLVGRLILMLCSLSDLICESMINYIISNEPDIIFLSKVPDTIIQTIFLVFCKKSLWPSTRTWEFSLQNFFNSISKEIKESKKERQITLLKGIHDIFSLENEVFRVFCNSSSLYSIFILFGNKNDKDIRKLSSLLTFKLIKQKKNVSEKFLENFIFNFIIGCFKEGRNETLIGAYSILTYLFTIDSSMAVTLFLKDGFLEEISSDIKNDNEVNLFLLEMISSSCINIDCRKKLLEIFMPVLNDLKKQKNIKIYSLSKIIIIKLTSQTNKEQNINKEDILNLAKNLVLIISQDYNDTNMSFIEGLAYVSMFSHVKEYLASEEKLFIAISERVKKEPSDINFIYPAFVSIKNIVNYKSELTEEQKQIIKLKSIAQGSSENSEDILESNEKVTERCFKIINYQMSMTLNLALSCHSDAIKTLCSKIILSFSIEKKHRIILAKQGVIRILYNIIKDYQTKTLSIEDSENNFLYPAIISLVKILITVNPNLIFDRSRFQVDDLIKPIYECLKISENDNSIVQFECLLALTNLASMNIEIREKLVSILWPMIELLWLSNNELIQRSTIELICNLVACPSGVAIFKKNKQRVHILLALADSPDKNTRSAAGGALAILSDDLSICKIILEKENGIKIILDMINEDVEDLIHRGLVCIANIIYSLDFKDKVLFERLNIIEDLYKIIKKTENKEIIDLSYQIIEELQKKIKYIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVM2</accession>
    <name>M7NVM2_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00783</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872687.1">
        <property type="nucleotide sequence ID" value="XM_007874496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVM2"/>
    <dbReference type="STRING" id="1069680.M7NVM2"/>
    <dbReference type="GeneID" id="19894481"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00783"/>
    <dbReference type="eggNOG" id="KOG1550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007931_0_0_1"/>
    <dbReference type="OMA" id="DRSFSEW"/>
    <dbReference type="OrthoDB" id="27934at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF147">
        <property type="entry name" value="SEL1L ADAPTOR SUBUNIT OF ERAD E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082486" evidence="3">
        <location>
            <begin position="24"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="758"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR11191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="798" mass="91629" checksum="139723CF131F9ADC" modified="2013-05-29" version="1">MGLNKLFFMVILFFFRSIFLVQSNTETNHQEKGKNPEKRMNHTEELRNALELDIVLDFAVQDINANDLYAESLEILKNVSYKILPNYSWSQKGLLRLFNTFKYIISKFIIIQLTHQQECSSEYNFSRNKVSKVSSMLKKAAALGHNDALYLLADMHFYGNYSHPLDLYKAFLFYKELALRTGNATAQFNLGLFYAVGMVEQVPRNQAKAMLYFMFAASQGDIRAEMILGYRHYMGIGTPQSCQIAAEYYKKVADKVMYHFDSGPPGGILLPRIPRKFADDEGGIYGEGASVVSSGPDYKKRKKLIGKILRIEKKEMDNYIDYYSYIAEKGDIEAQLLLGKLFYLGTSSMDRDFKKSFSYFKKIARLYWKKNGEPYDEKYGLGAAETARYLGLMYFRGEGVAQNFRIAKIWFQRGINIGDAACQNGMGMIYLKGYGDTNIDIQKAAELFKAASDQGLSAAKVNLAKIYLAQKDYTKASILFELAWDKNPVEAAYYLATMSYNELSKESSCQRTVTYYKYVSERIGLIYSTLDEAERAYENNNIYMTLIDTLIAAEQGYEAGQSNVGWLLDKEKSFSSRNQKKYFPMSDQLSLIYYTRAAKQNNIDAMVRIGDYYLEGIGTKADSSKAIKCFMSAADTGMSALAIWNLGWMYENGIGIQQDFHLAKRHYDNALSTSSEAWLPITLSLIKLRIRSFYKSILNGTTTNTSKQEKENINIINRLKNFIKRVLNSLKINDVEENDDALELDYDNQDFYENKDDFFETIVILILCLLITFMIYYRQARLHIGLRRNLNTQNLHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVS1</accession>
    <name>M7NVS1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PNEG_00820</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872727.1">
        <property type="nucleotide sequence ID" value="XM_007874536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVS1"/>
    <dbReference type="STRING" id="1069680.M7NVS1"/>
    <dbReference type="GeneID" id="19894518"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00820"/>
    <dbReference type="eggNOG" id="KOG0944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009884_1_0_1"/>
    <dbReference type="OMA" id="FVPCEHT"/>
    <dbReference type="OrthoDB" id="361536at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02658">
        <property type="entry name" value="Peptidase_C19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14297">
        <property type="entry name" value="UBA2_spUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000396">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016652">
        <property type="entry name" value="Ubiquitinyl_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041432">
        <property type="entry name" value="UBP13_Znf-UBP_var"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF664">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17807">
        <property type="entry name" value="zf-UBP_var"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016308">
        <property type="entry name" value="UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="17">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="17">
        <location>
            <begin position="149"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="16">
        <location>
            <begin position="299"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="15">
        <location>
            <begin position="577"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="15">
        <location>
            <begin position="634"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="716"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMR11231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="760" mass="87719" checksum="E21CC9C50C195A27" modified="2013-05-29" version="1">MTCSHLLQIHTPDAIQNIYSRECTQCFDSWDNLLGIDVCLFCFNAGCLDKQRHHALTHFERTQHPLVVNIRRITKNMDQRNKSLQKQRKLVIEEKIEAYDIQTCVKCYSCKISDICDESGHLKNVIDSILSSPSSIQKNEMKSWEQEITCCEHAFSLFQDERVNDYRLFSSCIQCDLKENLWLCLQCGNVGCGRRQNIGIEGNGHALLHFEKTSHPISVKLGTITPEGTVDIYCYLCNDEVLDPDLPAHLKHWGIDINEHEKVEKNLIELQLEQNMKWDFVSFDSNSKNEKLLSGPGLVGLKNFGNTCYLSSVLQVIFSFKVFQERYMSSFQEHPLHCKFSSPSLCLECQLNKIADGLISGRYSTSTENMNSLERIRYENAITPSMFKMLVGKDHPEFSTMKQQDSFEFLLHLSKLISQKSRASNLYDPTTVFRFRIEQRLQCLSCKCVRYSSHDQDNISLSFPTKNDSDDESILKEITLEECLDLYTSDESIVYFCKSCGEKGNANRRNLFSTFPEIFVINIQRFELVNWVPRKLDVSIIFPEDKINLDKYLFEGIPSNENVLFDDQKNSLSNEPLINMEYCKQLHSMGFTWAQSKKALIETENSGVEAAMLWILSNRDSLNDDNTFESVFPKIDDKQIKILEDMGFTSSQARKALKETDSNTERAIEWLFSHPDDNINDFEINKNGMTGLNKLPATYKCQAIICHKGGSVHAGHYVAFIKKHIFDKEEWILFNDEKVSQVNDINEAHKTSYIYFFQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7NW67</accession>
    <name>M7NW67_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_00398</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872272.1">
        <property type="nucleotide sequence ID" value="XM_007874081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NW67"/>
    <dbReference type="STRING" id="1069680.M7NW67"/>
    <dbReference type="GeneID" id="19894096"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00398"/>
    <dbReference type="eggNOG" id="KOG1827">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_506375_0_0_1"/>
    <dbReference type="OMA" id="FVYECAL"/>
    <dbReference type="OrthoDB" id="1742084at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054551">
        <property type="entry name" value="RSC4_Ig-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF19">
        <property type="entry name" value="PROTEIN POLYBROMO-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22994">
        <property type="entry name" value="RSC4_Ig_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="51"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="179"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR11371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="561" mass="63646" checksum="A0B306BE1ABFFAC7" modified="2013-05-29" version="1">MEDKRKIDSSGENEHESRLRKRTRTNVYNIEDILEEGQRLFKAVQEAKDSTGRLISENFMRLPSKRLYPDYYELIEKPIALETIKEKLRKKDYASTDEIRDDFLQICNNARRYNVTESQIYQDAQQIGKIIKTWGEEINALNKAEETKKFKIVHKNSQKNVLELAQEILSELKAMKDSSGRTYSDIFLEVPSKKEYPEYYQIIQKPMSFNIIEKKIKKNQYIKLLDFENDIRLIFANAMVFNEDGSQISNDAKILLKFFQKRISRKKESIDQSEEPESSPIKVKLNVSQSLTPKIRLSIGSKSSVTTDNSETSKSIIRLPMSPQAKSSNFKTEEVDSITAKSKTLIPAPIPASTTTSTISTRSIPLAPIPKLVAASIPSTSQTPIHLSKYSPHDIIPVTQSPLRPRQTSEPCWKWSEIKDGSQPLISLITLHTPSFLDIPSPYQIHLPSSPYGSKISTIILPASHHTLLVTPTLSSSLLSKPYHFTVAINSLKIAPNISPNVFLSRRSDTHFPKNTYEVKLSKGVNAIECVLTIPSKSAAKNSLSIEPSEKERLVIFVFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWA6</accession>
    <name>M7NWA6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell division control protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871877.1">
        <property type="nucleotide sequence ID" value="XM_007873686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWA6"/>
    <dbReference type="STRING" id="1069680.M7NWA6"/>
    <dbReference type="GeneID" id="19893724"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00026"/>
    <dbReference type="eggNOG" id="ENOG502S6JC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052857_0_0_1"/>
    <dbReference type="OMA" id="YMNILLD"/>
    <dbReference type="OrthoDB" id="5357220at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012535">
        <property type="entry name" value="Cell_div_Cdc14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08045">
        <property type="entry name" value="CDC14"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="28017" checksum="E50B768C45B853ED" modified="2013-05-29" version="1">MEKIRQNQEILESEIKLRIQHILSQAFDNLSSYDPVNMREGQRSIESLMAEICLGGKPGLKEFCELQDGFELNIATQLITCLERLLGKDTNHPISSHICHTLELLQGSLLLHPASRSLFSRHINMNILLDLLEPQSEPEVHIATLATLVAALVDNWDNVRVFESLNGLASVASLMKSKNSTQKVKLKVAEFLYFYLIPEPTFSGPIINKKLNIRRSTEEKELMLAKYLHNVRSLVKDLQELTPFGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWP4</accession>
    <name>M7NWP4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell division control protein 73 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00141</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC73 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872002.1">
        <property type="nucleotide sequence ID" value="XM_007873811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWP4"/>
    <dbReference type="STRING" id="1069680.M7NWP4"/>
    <dbReference type="GeneID" id="19893839"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00141"/>
    <dbReference type="eggNOG" id="KOG3786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025849_2_0_1"/>
    <dbReference type="OMA" id="FRPDYWN"/>
    <dbReference type="OrthoDB" id="2186602at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11990">
        <property type="entry name" value="RNA polymerase II accessory factor, Cdc73 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007852">
        <property type="entry name" value="Cdc73/Parafibromin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031336">
        <property type="entry name" value="CDC73_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038103">
        <property type="entry name" value="CDC73_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466">
        <property type="entry name" value="CDC73 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466:SF8">
        <property type="entry name" value="PARAFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05179">
        <property type="entry name" value="CDC73_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Cell division control protein 73 C-terminal" evidence="5">
        <location>
            <begin position="221"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR11707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="394" mass="45487" checksum="5F5C589157271371" modified="2013-05-29" version="1">MSENIENKIASASTISIKDPLILLKISILESCPPKFLSSENIESVVPRLEEAEYLGFSNGVIVSLKEKTRFIRKETGEPFNLLSIFFAWQLKDANVAEYIQRCGESDIKNLSFLEKTDLVTWLDGAAESEHIQPLEEEKSAILTIQRRTGFEHPERNPVLLNIYAQERIVGSRHTVLRGLKPIDFSAVRKDAYEHFISKSRNKHSGNTTAPPLGKELKVRHRDPIILLSPSASSLLTMYNIKRFLDEGVFVPPEEALQINGGNRVSELIAISHTSRIAKGLSYRFVIVQGVDKFKPDYWDRVVCVFTTGQAWQFKEYKWSEPRELFHHVKGFIIQYVGDPPHPATKEWNVESVRIERFRRHTDREVVSRLWESLERWMDNHPVWRTMGRRKTYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NX35</accession>
    <name>M7NX35_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S acidic ribosomal protein P0</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00155</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL10 forms part of the P stalk that participates in recruiting G proteins to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872016.1">
        <property type="nucleotide sequence ID" value="XM_007873825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NX35"/>
    <dbReference type="STRING" id="1069680.M7NX35"/>
    <dbReference type="GeneID" id="19893853"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00155"/>
    <dbReference type="eggNOG" id="KOG0815">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053173_1_1_1"/>
    <dbReference type="OMA" id="DMNPFKL"/>
    <dbReference type="OrthoDB" id="10259902at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="uL10_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039087">
        <property type="entry name" value="L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="6">
        <location>
            <begin position="109"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR039087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="307" mass="34091" checksum="E529A985446632EF" modified="2013-05-29" version="1">MKKNKDQKKRYFSRLYDLFSEYKSIFVVNIDNVGSQQMHKVRQELRGSGVIFCGKNTMIRRAMHDFLYDLPYLETLLPVVHGNIAFVFTNDDLKSSRSKIMKNVVSAPAKAGIIAPSDVIVPAGNTGMEPGKTSFFQALGIPTKIARGTIEIISDVHLIHAQTKVGASEATFLNMLNILPFTYGITILHVYDQGVLFSPSILDITEEAFIGYLKSAIQNVASISLALNYPTIVSVLHSLVNSYKNLQAVSITSDYIFEGTQKIKNILENPDAYVVVSAPVIESEAPSKEEKIEEEDEDEDMGLSLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NX93</accession>
    <name>M7NX93_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH TFE/IIEalpha-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_00199</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIE alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872066.1">
        <property type="nucleotide sequence ID" value="XM_007873875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NX93"/>
    <dbReference type="STRING" id="1069680.M7NX93"/>
    <dbReference type="GeneID" id="19893897"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00199"/>
    <dbReference type="eggNOG" id="KOG2593">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035744_2_1_1"/>
    <dbReference type="OMA" id="ILIRYPC"/>
    <dbReference type="OrthoDB" id="361102at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR11771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="390" mass="44980" checksum="C310AFC3A31C3CAB" modified="2013-05-29" version="1">MSNPELKVIHRLIRRVGCAFYEVKDRILLDALLKHSTLRDDHLSMIMDMQLKEVRRICGGLKENRMIDEYHSRMDTREGYSRPNGRTYYYINYRATIDVIKWKIHKLVKTVGDRMTKDYDTKGYICPVCMRQYTSLDAVSLVSPDAMSFLCTDCGTALNDNEESFEVKDSQERLSRLMSQMSKIISSLKEVDEIVVPENTFIMAIANAIPPDLDSVSLSEYLEPVSTNTVTASTVFHSTAAEPSILIDFDMESKSMTKDFGKKEKQVSSLTENDLPIWHSQSTIMNDFTDTDNLYKNINSEDFLDFQNNGLKDNVSKKEKPEAIENAVAEYYAKLRARKDTEIKDETKDLDYDDFDNDFEDVDDLEIGSFLNDDYLELQKRHHDTNGLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NXD0</accession>
    <name>M7NXD0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal lysine N-methyltransferase 4</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that monomethylates 60S ribosomal protein L42.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872116.1">
        <property type="nucleotide sequence ID" value="XM_007873925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NXD0"/>
    <dbReference type="STRING" id="1069680.M7NXD0"/>
    <dbReference type="GeneID" id="19893944"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00246"/>
    <dbReference type="eggNOG" id="KOG1337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_553375_0_0_1"/>
    <dbReference type="OrthoDB" id="441812at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011383">
        <property type="entry name" value="N-lys_methylase_SETD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF34">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011771">
        <property type="entry name" value="RMS1_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="520" mass="61928" checksum="9D25040B335D3FB4" modified="2013-05-29" version="1">MNTTKTDEIINKNIDQQRISILMDWLKSKNIYIHSAIKLGKRDDGFFVYTEKFIKKNTIILKVPKNAILSPKTSLLSFFLDKTKIPSILSVCIVYMYEKSLGQKSPWYGYLQIMPDKVDIPKLWNHEKKWLKGTEIEYVGGLDISELQSAYNELILPFIKKNKEILNQRIFTYNNFLKAISVVRSRVFEIDKFHNLGLVPFADMFNHATNEHIHFQTFYNVCRHCGLIYCKHIFKLKKYKKTQYEDTCDMIVHNSPSAFDEVYNTYGTHGNDILLSRYGFALHKNKWDRISMSKIFQKNDMKSDRLLWWKLNGFNASYKMGLFKRYFSKNDIKNYFSSDSNNHNDKEIHSYHNIQYLFLQDSLFITFPSDPSSPLIFFIILLSLSHKLFKNLEKNTKKTNIYILNIIRLQLLYFHTGSIKNLKYQKYTTLLIIFKINKFLSNAIDSRLKKYNQTLILDNLVYENIKTQENKRKHWTKIVLQNEIDILNNTKKKCIKLIHKTKLILKYQKLYSFKIKKNYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M7P475</accession>
    <name>M7P475_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major surface glycoprotein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_03134</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08660.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875192.2">
        <property type="nucleotide sequence ID" value="XM_007877001.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P475"/>
    <dbReference type="STRING" id="1069680.M7P475"/>
    <dbReference type="GeneID" id="19896821"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03134"/>
    <dbReference type="eggNOG" id="KOG3544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010455_0_0_1"/>
    <dbReference type="OrthoDB" id="5400168at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021041">
        <property type="entry name" value="Maj_surf_glycoprot_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003330">
        <property type="entry name" value="MSG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02349">
        <property type="entry name" value="MSG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12373">
        <property type="entry name" value="Msg2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006963417" description="Major surface glycoprotein 2 C-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="domain" description="Major surface glycoprotein 2 C-terminal" evidence="4">
        <location>
            <begin position="949"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="812"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1118"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="581"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="833"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="883"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="927"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1126"/>
            <end position="1146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08660.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1169" mass="130917" checksum="53EE387282714EA7" modified="2016-03-16" version="2">MIKIILIPILNLIAHIYGNQNVDLSIRSSQINAVNPSFKGLIDNDENIYAFILKKDYIDENKCKAKLEEYCKELKDIDPELNKVDSKVKKICDNNNKEKECKNIKGMIQEKLKIINKGINNFFQYGGTSRDCIEYLEECSFFQEVDSGEIKKNCISLRNKCTKKKNIVIAQEIILRILSVSSISLSECKSNIYNFCTLLAWESDALMELCIDTNNFCTDLSYVIYSFCIFIGDFDNNKECHEQLENCYFYMPFCQNLKEKCDKWKKECLKKNITYESPDLDLNPLKPLKTVFQVIKLEDIYKGEADKGNIIGKPEKMNFRDFILLLSRLEGMHNIEEACENAVEKYCKNTKYLSYEIESFCNDQNKGKKCAELTNVKARCMNFKMESYLKGLSTEISSEESRVLEWDKLPKSLTRKECIHFSTECLRLSGICKNGISQVCNHINEVCHRKAENTALNKIFMPALRGILYNFGSNASMLSCQENVLDICTTFKNSNKRYFAKCLRPKEQCLELKNYIFSQSEELEQVLDSVRDLPVESECIKLQEECRDLKGYSYFIDNKCITLNRRCRYLEITEELRKRFLKRKDDSLKTAENCIKALKEECERLFRGEMNPFSVSCASLEETCSFMIERTTRDCDSLKNSIKSKKIISKIGNGKANETLAEEICTLFDPYCHQYMENCPDRLKKGDTGNEKGVCLELEEKCKPFFEKLKLEDELMHELKGSLGDETKCKETLRKHCTERKKEGNQTLNSLCEDAKKEELCKKFVGKIKGKCPTLKNELDKEKDELKKKKDEYEKVKQEAEEFGKEAKLLLSRPEQDGQGGGSKVQDGSVPKPVGPPVQPPAPAQPTPGGVPAPTLAPPAQPTPGGAPLPVPPAAPGGTPGGAPLPVPPAAPGGPPVQPPVPVPPPAPGTPPAGPAGPAGPSGGTPAGPPAGPPAPGGSTPSGTTNTSNVILVRRTFVSGKASEADKKAFVATARALELYLELKEKCKALKRDCDFRKDCKECETVCTEIDKLCEGIKPLKVTPHHTMTLMTTEITTTTMITTTTRMITTTKTTTTTTTTTTTTTATKSIHGGKVTEQCAFPQTTDIWMTSTSLHTSTLTSTSTVTSTVTLTSMRKCKPTRCTSDSSKETETQKEEEKEEEVKPNEGMKIRVPEMIKIMLLGVIVMGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7P589</accession>
    <name>M7P589_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase Rpb4/RPC9 core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02817</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874851.1">
        <property type="nucleotide sequence ID" value="XM_007876660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P589"/>
    <dbReference type="STRING" id="1069680.M7P589"/>
    <dbReference type="GeneID" id="19896506"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02817"/>
    <dbReference type="eggNOG" id="KOG2351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110332_2_1_1"/>
    <dbReference type="OMA" id="HRKTQNE"/>
    <dbReference type="OrthoDB" id="2186918at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990328">
        <property type="term" value="C:RPB4-RPB7 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045222">
        <property type="entry name" value="Rpb4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21297">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="4">
        <location>
            <begin position="28"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="148" mass="16995" checksum="842631D52EC5485B" modified="2013-05-29" version="1">MPVTARRHRVRQRTRLEEEDASRLQLGEEFANATCLSVSEAKIILEAVLLQRQKELGDEIVMTDVIRKIKDYLNIFARFRTQESVHAAERVLRGDPDLHSFETAQLGTLCCEEAEEARTLVPSLSEKKSDEALQTLLDELSNLRRFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7P709</accession>
    <name>M7P709_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Meiotically up-regulated protein Msb1/Mug8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873836.1">
        <property type="nucleotide sequence ID" value="XM_007875645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P709"/>
    <dbReference type="STRING" id="1069680.M7P709"/>
    <dbReference type="GeneID" id="19895558"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01864"/>
    <dbReference type="eggNOG" id="ENOG502RBV5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_358664_0_0_1"/>
    <dbReference type="OrthoDB" id="3362494at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037508">
        <property type="entry name" value="Msb1/Mug8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012965">
        <property type="entry name" value="Msb1/Mug8_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093:SF1">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08101">
        <property type="entry name" value="Msb1-Mug8_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meiotically up-regulated protein Msb1/Mug8" evidence="1">
        <location>
            <begin position="52"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="782" mass="91643" checksum="C8D9E90DCBA34581" modified="2013-05-29" version="1">MTKYFNKFKRSYLFKKQDQVPINTEESIVYDREADIRNFRSDDPWNWEFVLEEEVCDLLEACYIEVKSRGVMIPLVFLPFRPMSDVLSTKAYIRKFFSVDNSQVHKNQLIQELPIVDIYVIIGIIRWCWLRLIDGVVGWNVYEAFRKLEKEAKYPYNAFSDYIPTIVKSKIREKIILGFFDILSAIAAYSKINGLCGDKLSRTAGWWAFNFKNKDQGFHRGYSNWKRSADANEHLFFAYLRSIKEQHTNTELYVPNPLPLSLVKLLEQTPYPLSVASPITLHHKDTLCIDVFSNIPSPNIFTILQRVAIQGLDTDDEISLALWKHRDHIENALTDESKRILMCISNTLINTSSPKECEKWEEFMNFGFDYIENKSSSPKTDSLYKIDKQNAYLIDNLNQHSTDLEPKTNPTLSLEKSPLHRIFPFNNAFPLINGIHPHPELDSATKINTEWLNESTISNKIRISLDESFWGVWIDSCSEETPIFKKTLFGKSFLFEIELDEKKWLVIEEQNNKCDKCISFNPFLANSSVENKQKFFNNLEKHKSSFSNDEEHKLRRTLSEYFKHQKNKFKIIQRYKTIKTKKKSLLEYKQDIIDKNIIRNSEEYLYRENNSLETLNSIKVPFSYSKIEYMVALNDKKKSDPSQIKQQDNISNPKIENEIEKLPIKDLNLYSYSLSTNKRYGILNEFNLKISDYSNSTSNIHHLTSKLSSFRTSIANKPKKDLPYILDNINATQNDGAVVNISNTNYQLKRYFTLKKYTGKLFRNSKHCKNTIPINYQIQKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7P733</accession>
    <name>M7P733_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Actin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01877</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the actin family. ARP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873851.1">
        <property type="nucleotide sequence ID" value="XM_007875660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P733"/>
    <dbReference type="STRING" id="1069680.M7P733"/>
    <dbReference type="GeneID" id="19895571"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01877"/>
    <dbReference type="eggNOG" id="KOG0676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027965_0_2_1"/>
    <dbReference type="OMA" id="YTTWTGG"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10216">
        <property type="entry name" value="ASKHA_NBD_Arp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000188">
        <property type="entry name" value="Actin like 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000015">
        <property type="entry name" value="Actin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="385" mass="43127" checksum="29F720575CF346BB" modified="2013-05-29" version="1">MEFNDVLTNQPICIDNGSGVIKAGFAGEDQPKSFFPSYVGRPKHLKIMAGAIEGDVFIGNKAQELRGLLKIKYPIEHGIVVDWDDMERIWQFIYTEELKTVSEEHPVLLTEAPLNPRTNRDQAAQVFFETFNVPALFTSIQAVLSLYASGRTTGVVLDSGDGVTHAVPIYEGFAMPSAIRRIDIAGRDVTEYLQLLLRKSGTVFHTSAEKEIVRIIKEKCSYVTLDPRKEEKEWINASISGGKDHAKEEEFKLPDGNVLRLGAERFRAPEILFDPEIIGSEYSGIHQVVVDAISRVDLDLRKSLFGNIVLSGGSTLTRGFGDRLLSEIRRLAVKDVKIKIFAPPERKYSTWIGGSILASLSTFRKMWVSAEEYQEDPDIIHRKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7P7M8</accession>
    <name>M7P7M8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent DNA helicase PIF1</fullName>
            <ecNumber evidence="15">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">DNA 5'-3' helicase PIF1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">DNA repair and recombination helicase PIF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PIF1</name>
        <name evidence="17" type="ORF">PNEG_02041</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the helicase family. PIF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="15"/>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874021.1">
        <property type="nucleotide sequence ID" value="XM_007875830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P7M8"/>
    <dbReference type="STRING" id="1069680.M7P7M8"/>
    <dbReference type="GeneID" id="19895735"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02041"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001613_0_1_1"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033678">
        <property type="term" value="F:5'-3' DNA/RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061995">
        <property type="term" value="F:ATP-dependent protein-DNA complex displacement activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019237">
        <property type="term" value="F:centromeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990814">
        <property type="term" value="F:DNA/DNA annealing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160225">
        <property type="term" value="F:G-quadruplex unwinding activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010521">
        <property type="term" value="F:telomerase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990426">
        <property type="term" value="P:mitotic recombination-dependent replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032211">
        <property type="term" value="P:negative regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903469">
        <property type="term" value="P:removal of RNA primer involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071932">
        <property type="term" value="P:replication fork reversal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019985">
        <property type="term" value="P:translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18037">
        <property type="entry name" value="DEXSc_Pif1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001226">
        <property type="entry name" value="ATP-dependent DNA helicase PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03176">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048293">
        <property type="entry name" value="PIF1_RRM3_pfh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="316"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="DNA-binding region" evidence="15">
        <location>
            <begin position="733"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="324"/>
            <end position="331"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMR09860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="801" mass="91036" checksum="BE3433F2563BAEEA" modified="2013-05-29" version="1">MFQRSQEKHHQKIIYAPRSYISKISDFKQTKLQLMRNNITSNYIKSGPLKPVDASSLNIHPISVAHESSIFNDHNIKKNQKPSSSSIKFLETLNQQNKATGASIFLKNTSDENLIDDLHVNENDIDDNLNLDSEHDESFYSWSSSPMQYQHLALSGLKDQFSNECQSSDTIFQPKLSNTTLFEEVICETEVSNSLDSLEINSGNPKDLKNTALKENHCALQVDQKNEQFQDSGRILFLNKTEGPIELVKSEMKNRKRISSDILNKSDIHKIDNIQSFRFESKDIQKKSIKQKKNKKLPGLFLSEEQKTVLKIVVEERESIFFTGSAGTGKSVLLREIIASLRKKYAKEPDRVAITASTGLAACNIGGVTLHSYAGIGLGRDSSEDLCKKIRKNKKCLSRWLRTKVLIIDEISMVDAELFDKLENIARKIRNNENPFGGIQMIVTGDFFQLPPVPDQGKMSKFAFEAKKWKDVISHTIALTHVFRQKDQDFVEMLNELRLGRLSYNSINKFRSLDRELQFDDGLEPTELFPTRNEVDQANATRMRSLSGALRTFEALDSGTVDKIQRDKLLSNCMAPARIDLKEGAQVMLIKNFDDQLVNGSLGKVIGFMNEKTFQIWQEDEPDDDPFNYHEQIDDSNIDEIKKRKKRRIAGMQSAAATGKLWPLVRFTLSNGLTRDMLVQPEQWKIELPNGEVQASRSQIPLILAYAISIHKAQGQTLERVKVDLGRVFEKGQAYVALSRATSQKGLQVLHFEARKVMAHPKVSLFYKSLVNTGDLKRKANVDSDFNKEKNMDDFPKNYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7P8E4</accession>
    <name>M7P8E4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Pheromone-processing carboxypeptidase KEX1</fullName>
            <ecNumber evidence="15">3.4.16.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Carboxypeptidase D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Pheromone-processing carboxypeptidase kex1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PNEG_01420</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential release of a C-terminal arginine or lysine residue.</text>
            <dbReference type="EC" id="3.4.16.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.6" evidence="15"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873359.1">
        <property type="nucleotide sequence ID" value="XM_007875168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P8E4"/>
    <dbReference type="STRING" id="1069680.M7P8E4"/>
    <dbReference type="MEROPS" id="S10.007"/>
    <dbReference type="GeneID" id="19895117"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01420"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008523_11_0_1"/>
    <dbReference type="OMA" id="PLMFAGQ"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000121">
        <property type="entry name" value="Carboxypeptidase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF190">
        <property type="entry name" value="PHEROMONE-PROCESSING CARBOXYPEPTIDASE KEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 21" id="KW-0732">Signal</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082662" description="Pheromone-processing carboxypeptidase KEX1" evidence="21">
        <location>
            <begin position="20"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="566"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00040628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EMR10145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="590" mass="68920" checksum="EF8ABC0A139B1306" modified="2013-05-29" version="1">MTKIFIFFLIWAYSRIIHAVSVSNYYVENMPGLVENLNLKLYSGHIKVNEKNENSLFFLFVENRYIVDKQRTVIWLNGGPGCSSMDGAFLENGPFRMTKEGLLSGNQGEWNEFSNVVFVDQPAGTGLSYSLPENYPHGLSQTVSDFLVFLDNFFEIFPQYKNDELYITGESFSGQYVPYIANAILKRNEENNKKNYNLKGILIGNGWIDPLTHYKSYLPFSIKNGLVKKGSEQEEQIQKAVKDCELAFSKKQLKDIQNCDSILSMIIKPDLREDKKCVNMYDLRLKYPSCDMKWPNGSVQLTSYLRKPEVLKALNVDNDKKIVWQECNLRFTETFLRYSSPPSIELLPYILSKIQVVLYSGDKDIICNHLGTEDLINNLEWNGRKGFIQEDGTWIPRQDWIFMDKIAGYYQYDRNLTYIIIKDASHMVPYDKPLESQDMLNRFLGIDQEIIKKIRESRAKSETGSFNPNSKNNSLLEKEKNAWKLYYHILAIILVFILIGTIYLTWRHCKSRKINDQYVDKFNHSADSEYWNENRSQYYKNINTPFNRKNDFHDFENYPGIIYDKASSPQTSQTKEDSILDYNEPFRTTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7P9G0</accession>
    <name>M7P9G0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01217</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873134.1">
        <property type="nucleotide sequence ID" value="XM_007874943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P9G0"/>
    <dbReference type="STRING" id="1069680.M7P9G0"/>
    <dbReference type="GeneID" id="19894914"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01217"/>
    <dbReference type="eggNOG" id="KOG0294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031466_2_0_1"/>
    <dbReference type="OMA" id="CKRTEGE"/>
    <dbReference type="OrthoDB" id="308449at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051959">
        <property type="entry name" value="PAK1-Kinase_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675:SF1">
        <property type="entry name" value="P21-ACTIVATED PROTEIN KINASE-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675">
        <property type="entry name" value="PAK1 INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="138"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="270" mass="30549" checksum="B652F22A46BB3EC8" modified="2013-05-29" version="1">MVQVHEDFEKYRNLVPSLRIIAGTYEGILYGIDVILSLKDDMKINIHFNPVWMFESNHGCIHTIAIGGRYLVCGGVDEVIKLYDLRKKKDIGSLHHQSGTITGLVFSSFTSPKFLISVSDDGTMAFFRTKDWLPLSTIKTHHGRINSISIHPSGKIALTVGSDKNIRLWNMMTGKKAGRYNLNKNEAFYVQWNTLGTQYAVLLNKEVMVYDMSATLVYCFSSLTRFNSMHYTISKKNHEILVLGSQNGCLQIYDSSNGKLIVSFVAHENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7P9T3</accession>
    <name>M7P9T3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01336</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873264.1">
        <property type="nucleotide sequence ID" value="XM_007875073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P9T3"/>
    <dbReference type="STRING" id="1069680.M7P9T3"/>
    <dbReference type="GeneID" id="19895033"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01336"/>
    <dbReference type="eggNOG" id="KOG4209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054059_2_0_1"/>
    <dbReference type="OMA" id="EAISHMH"/>
    <dbReference type="OrthoDB" id="252020at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061574">
        <property type="term" value="C:ASAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481:SF0">
        <property type="entry name" value="LD23870P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481">
        <property type="entry name" value="RIBONUCLEIC ACID BINDING PROTEIN S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="38"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="113"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR10635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="243" mass="27712" checksum="1FB34C197333A4B9" modified="2013-05-29" version="1">MDSRSAASSRSRSLKGYRNSRSLSRSSRRTSSPTRNSSKILIEKLTKNVTAAHIQEIFGSYGEIRSVDMPMNRRLNINRGLCYIVYASSSSANAAISHMHEGQIDGSVITVSIVTPRPPNTRKSSFSPGRRGSMGVKRYRRPYSPPRRTIRESRLGDSYRPPYRSSKSSSPYYRHNGNSKNRLSSYSSYSSRSRSYSTERSRSRGRSYSRGRSYSRERSYSRGRSYSRRRSYSRSRSISNASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAU3</accession>
    <name>M7PAU3_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_00597</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR10995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872493.1">
        <property type="nucleotide sequence ID" value="XM_007874302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PAU3"/>
    <dbReference type="STRING" id="1069680.M7PAU3"/>
    <dbReference type="GeneID" id="19894295"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00597"/>
    <dbReference type="eggNOG" id="KOG4442">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008492_1_1_1"/>
    <dbReference type="OMA" id="AQSQPCY"/>
    <dbReference type="OrthoDB" id="422362at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046975">
        <property type="term" value="F:histone H3K36 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19172">
        <property type="entry name" value="SET_SETD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.100">
        <property type="entry name" value="Set2, Rpb1 interacting domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025788">
        <property type="entry name" value="Set2_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044437">
        <property type="entry name" value="SETD2/Set2_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013257">
        <property type="entry name" value="SRI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038190">
        <property type="entry name" value="SRI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17907">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08236">
        <property type="entry name" value="SRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00570">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51568">
        <property type="entry name" value="SAM_MT43_SET2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AWS" evidence="10">
        <location>
            <begin position="134"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="189"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="511"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="574"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="667"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="784"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="514"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="574"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR10995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="824" mass="95743" checksum="DEEEE99A8DCE228D" modified="2013-05-29" version="1">MAPYPYDYDHSYNQDRSSEDQLIEDIWAQDDWEERDFEVPDIYTSYTKKKDDNDIPRCSETEAENLTDSHVQYALGYDKNSGTNSNKSMETKRPQKSIKLYNDLPSAKEEALASFEEHFCNIYHSKDLGESGQEEIMTCECKSEWNGTENLACNKNSDCINRLTSVECTDDCNCGEDCQNRKFKLRQYSDIDVIKTKKKGYGIRANSDLESGQFVCEYIGEVIDERKFRRRMKIYSEENIKHFYFMMLQRGEYIDATRKGGLSRFLNHSCSPNCYVDKWVVGTKLRIGIFCKRNIIKGEELTFDYNVDRYGTIAQPCYCEEPGCIGIIGGKTQTEFHSKIPQNILKALGFENLDFWDFSSAKKIRKKKKGETDEEYYNSMQSTPVDENGVTKIMSALLQCKERWIINKLLLRIYSSNDLTIQRRVMKMHGYQILGSVLRDWKEDFDISNMILNIFLRWPRITKNKISSSKIETTIQILASHENEELRKTAQQLITEWGNLSMAYRIPKKPKAQQAETIYSDSETSDNGSKLYQSPGSQSSPISNERYSRFSRSKNYDNYTTNKTQSFRGERFWRPDSRFSDEPDVRGHKLRGPRSVEENTRILPPGWAVAKTQDEKPYYYCGDKVQWEFPLEAAPPPPPPPPLVPFNNSSLDLQKIIDEANAELMERQNNTSKHDPRNNKNNASKGKDHKHSSNISKKEKLPLEKILIKTFAKYVPNVITKFQDELGKDEIKKRAKEIVEILVRKEMRPGHEIRNVYELSSTKKKKIKEFSYTYIEKVISKKKEKNMQKTNNSHKKENANGCAENTSDKYFSTILKGTQDQNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7PBP2</accession>
    <name>M7PBP2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA wybutosine-synthesizing protein 4</fullName>
            <ecNumber evidence="5">2.1.1.290</ecNumber>
            <ecNumber evidence="4">2.3.1.231</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Leucine carboxyl methyltransferase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PNEG_00309</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine + CO2 = wybutosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:37119"/>
            <dbReference type="Rhea" id="RHEA-COMP:11844"/>
            <dbReference type="Rhea" id="RHEA-COMP:11847"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73544"/>
            <dbReference type="ChEBI" id="CHEBI:74275"/>
            <dbReference type="EC" id="2.3.1.231"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36903"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
            <dbReference type="Rhea" id="RHEA-COMP:11844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:74275"/>
            <dbReference type="EC" id="2.1.1.290"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.290" evidence="5"/>
    <dbReference type="EC" id="2.3.1.231" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872182.1">
        <property type="nucleotide sequence ID" value="XM_007873991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PBP2"/>
    <dbReference type="STRING" id="1069680.M7PBP2"/>
    <dbReference type="GeneID" id="19894007"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00309"/>
    <dbReference type="eggNOG" id="KOG2132">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2918">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002761_1_0_1"/>
    <dbReference type="OMA" id="FCILEQF"/>
    <dbReference type="OrthoDB" id="47172at2759"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000043">
        <property type="entry name" value="tRNA wybutosine-synthesizing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46529">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46529:SF1">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13418">
        <property type="entry name" value="Beta-prop_TYW4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="JmjC" evidence="16">
        <location>
            <begin position="831"/>
            <end position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMR11280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1023" mass="119084" checksum="34D1070F4B469C17" modified="2013-05-29" version="1">MQISNKKDKIIQGTNDTSIVSKRSAEYCGYPFSENQYLRAFVKKPQRRSPVINRGYYIRCQAIETVIQNFVSEKNNRYKIIINLGCGYDPMPFRYISKPEFNYVRFFDVDFQDLIERKALIIQKDKELKEMSQKYVLSNKNKLELQYQLIGCDIRNLDLLKTIINEKCHNIESMDVLFISEVAMVYIQTEFSDKLIEWASSFPYASFVILEQILPCSKNHPFGRTMISHFNKLKTPLYSLDQYPTLILEYKRFSDRGWNYIEAFDLWTFWNYGIDKKTRNKVNLVEDFDEWEEIILFLQHYYVLIAKNLPSKKNILLSSPPEGHQYLNSNKQPQVFNKCMSNNSNSNFLSKKFYKVKGNITFHRRFGAASLFGQNTIIYHGGISESGRDKKTFLITHKENKIPELNIKLVDSRVCHTLDYCPKEDILICIGGRESPCKLSNSGWKHSHLTQNIIKPIPDGGRYRHGMIKVTLQNETRFIIFGGNKKTSKIVDKEWVMWSDKNGWEILRINSKDKPQPRWGMCIIWLPEREEGIICGGMNEDGLIYEDIWTFKITILNKEWFLEFLPWRNISILDIQCISRLGAKAVNVIGILNGDVLIVGGVSMFHCISWNDQFILLDLENQKIIPLNVQSLENDPILIGFDIIRRNNDIFILGGGCLCFSFGICWNDDILILSESNSDEEWLISEYENTKSCVPTFINTFNNNNINMPNSVILEHTNPIIRLISSIKINSKDEWEEILEKNMPIVLKELDIGTCVEKWTPEYLISRIGSTRKVIVHNAKTNFMNFHEKNFSYETMEFEEFINSIYKDGSKLYMRSISTKNPRTKPSLLEEDFPEISDDLNIPKELSQTICPNKFSSPLRISSKNIGMWLHYDVMSNILIQIRGSKKVQLYPPSDVLHLQFLPGSSSSKIPNIFTENPENLRNTHSHQVILYPGDILYIPAFWLHAVQSLEPSISVNVFWRHLDYQYYSTLTNDVYGNKDLKAYENGRILIKKIFEGFRGLTGDERGFYLQRLAAELIEMSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7PBQ5</accession>
    <name>M7PBQ5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00324</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872197.1">
        <property type="nucleotide sequence ID" value="XM_007874006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PBQ5"/>
    <dbReference type="STRING" id="1069680.M7PBQ5"/>
    <dbReference type="GeneID" id="19894022"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00324"/>
    <dbReference type="eggNOG" id="KOG0778">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024324_4_1_1"/>
    <dbReference type="OrthoDB" id="1939479at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016929">
        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070139">
        <property type="term" value="F:SUMO-specific endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.395.10:FF:000001">
        <property type="entry name" value="Sentrin-specific protease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606:SF141">
        <property type="entry name" value="GH15225P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606">
        <property type="entry name" value="SENTRIN/SUMO-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="288"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR11295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="479" mass="56907" checksum="15ED541F93BAF0B5" modified="2013-05-29" version="1">MSDELYYDFKDKKNLKIKKKMDEMFFSHKNMDVFQKSSDIFKNPLISINRQKNFTSYPVRLPKTTMTGRKLLENALKRYNNIIYPKTPSSLMSSCSQKTSLFQDIYNFQTPFTKRKYYSLKLNDSNNKSDSQDDNYEFHDKRTFEDYYTQNIRKTNNLFSPSFSFMNPSLSKNNDSLSSCSLKTHKKQLQDQTKYINDFQKHRFMNDNESFDDLIRQLKEYYKDESLYNWKNLQKEKQKRDYEIQKLKDLSIKSLDKPPPLSKEILKKVEEALFSNALKNPLIVKFNISITLRDIRTLRDKEWLNDEIINFYIALISERAKATPKGPKVYAFNTFFYTTLEKNGYQGVRRWTKRAKVNILEQDYVLIPIHLGIHWCMSIINFKKKRFEYWDSLNGKSGKVFLLLRDYLFQESGNTINLDDWIDYIPESGPIQTNGYDCGVFACKTAECIAREGSIDYTQDDIKELRKRMVANIIEGRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7PC83</accession>
    <name>M7PC83_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Lymphoid-specific helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_00523</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872411.1">
        <property type="nucleotide sequence ID" value="XM_007874220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PC83"/>
    <dbReference type="STRING" id="1069680.M7PC83"/>
    <dbReference type="GeneID" id="19894221"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00523"/>
    <dbReference type="eggNOG" id="KOG0385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_17_3_1"/>
    <dbReference type="OMA" id="WNICRID"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006346">
        <property type="term" value="P:DNA methylation-dependent constitutive heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000015">
        <property type="entry name" value="lymphoid-specific helicase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47161">
        <property type="entry name" value="LYMPHOID-SPECIFIC HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47161:SF1">
        <property type="entry name" value="LYMPHOID-SPECIFIC HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="159"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="546"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR11510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="765" mass="88789" checksum="C5D302BBBA344396" modified="2013-05-29" version="1">MEPKIVMDDKGIDRLKFLLEKSKIYTSILSEKLKKRVKDNEIQKKFISLEKKEIKSEFSDLDLLDHSEVSEKKEKDKLVSKKNNVSVKKTAKSKHGHGSRITDYFTMKVAETLCEPEESYQSKDDFDIADKTLSLISQPKLVTGCVLRDYQLAGVEWLASLYENGLNGILADEMGLGKTLQTISFLAFLREKGTYGPFLIAAPLSTISNWVFEFRKFAPEIPVLLYHGSKQERSSLRKSKMGMMHPDFPIVVTSYEVIMNDKLYLKRYQWKYIVVDEGHRIKNLNCKLIRELKSYDSANRLLLTGTPLQNNLTELWSLLNFLLPDIFDDLDSFQSWFDFSAFQDKKDEETLLKSMDVVSTLHCILKPFLLRRLKADVEQSVSKKREYILYSPMTIYQNELYNAILNKDVRSFLMKKHSSGFTSDEVLGVDNEEQNIQSSCVSKSIKINRRSVPRRNRSRISYSELRDDESSDSLDRWLYNGDEKKHKSLYKENLENNVSQLKLQNLIMQLRKVCNHPYMIGFHTYFDADKLLVDENIVNMSGKMLLLQRLLPTLFEDNHKVLIFSQFTKMLDIIELWAVNMQNWEICRIDGLTKQNERERQIEDFYENPNIKLFLLSTRAGGLGINLTVADTVIIFDSDWNPQQDLQAQDRVHRIGQDKPVIVYRLVSANTVEEKILERANSKRCLEKLVIQKGKFKSLMSISSKDDEEELTSMLLFEDAKKIVVKGKDDEILSNEDLKSLLDRSDDAYKISEKSTSCVNYRIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCR5</accession>
    <name>M7PCR5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00134</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871995.1">
        <property type="nucleotide sequence ID" value="XM_007873804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCR5"/>
    <dbReference type="STRING" id="1069680.M7PCR5"/>
    <dbReference type="GeneID" id="19893832"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00134"/>
    <dbReference type="eggNOG" id="KOG0191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030577_0_0_1"/>
    <dbReference type="OMA" id="NHVKRAT"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057305">
        <property type="entry name" value="Thioredox_PDIA6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24541">
        <property type="entry name" value="Thioredox_PDIA6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004083086" description="protein disulfide-isomerase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="9"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="387" mass="45225" checksum="487FFCC300C1B20B" modified="2013-05-29" version="1">MNLLIYFLFFFNLIKNVISLYGSKDQIQVLTSKNFFNFVKDSKHLSIVEFFAPWCGYCRELAPIYKKFAEEVSELINVIAIDCNNHQSIKICERYEIKGFPTIKFFIPQKGAEPKVENYEGPRTLRDLMLVSTSKIPNYVKKITDNIELFLEKNNMEKKIILFTNRMDPNGFFKTLALDFYNQVQFILIHQSYKKALELFEITKFPTIIFLHKKDKPVVYSGKLVYKEIYDFIKNYVLGETQETVNSEPVEEPKEKKFSLTELNSENEIFEKCIFKKGISIVVLSNSASNFYLLSQIAKTYNKFSYYFIDKSNVVFSSLLELIQISFEESEIILLNGQKGWYVTLQGKNANEILKVISTVMTGENIEKKKLDLNLINMISKVRRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCW1</accession>
    <name>M7PCW1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_03439</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875526.1">
        <property type="nucleotide sequence ID" value="XM_007877335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCW1"/>
    <dbReference type="STRING" id="1069680.M7PCW1"/>
    <dbReference type="GeneID" id="19897126"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03439"/>
    <dbReference type="eggNOG" id="KOG1156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006686_0_0_1"/>
    <dbReference type="OMA" id="MEMRADY"/>
    <dbReference type="OrthoDB" id="10263032at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010698">
        <property type="term" value="F:acetyltransferase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1040:FF:000003">
        <property type="entry name" value="N-terminal acetyltransferase A, auxiliary subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021183">
        <property type="entry name" value="NatA_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF2">
        <property type="entry name" value="N(ALPHA)-ACETYLTRANSFERASE 15_16, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12569">
        <property type="entry name" value="NatA_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000422">
        <property type="entry name" value="N-terminal-AcTrfase-A_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="593"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="811" mass="95798" checksum="1294A4AEFA2C9705" modified="2013-05-29" version="1">MAKQDLGPKEASLFRQIIKLYEIKQYKKSLKNADQILKKYPEHGETLAMKGLILTLLNKKSEGYEHAHRGLRNNLTSHICWHVFGLLHRLDKNYNEAIKCYLNALKYDKENLQILRDLALLQTHKRLFIQLVNTRNILLQLNPKQRQNWTAYALANYLNGDILASEKVLTIYENISGNNLRNYENSETILYKCTIIMELGNYIEALNYINSVECQVIDKMSIMEIKAKCFLKLQKKEAIAEYIKLLDRNSENCEYYMDLAKAKGLKNKNEVIDTNGLKQMYIDLEKRYPGSYVAKRLLLDFLSGDEFKIAINKYLKRLFKKGTPSTFISIKCLYSDKEKKDIIQNSVEQYLDNLYLKKDILCGVENETKNNDPTLLLWILYFLAQHYDYLRETEKALMYINRAIEHTPTLVELYLTKARIYKHSGNTQLAMFFLNNARKLDLQDRYINTKCAKYMLRNDCNEEALNILSLFTKINIIDGPIDDLVDMQCIWFILEDGQSFLRQKKYNIALKRFETIRKIFNIWSEDQFDFHSYSLRKGTIRTYINCLKWEDNLFSHPFYLKAAQLAIKIYVLLYDYPNLKNDLNYIDSIAFDNKETLKQMENIQFQNNNLNKKYKENEKLNFDDDPNGNKLIQTENPLQDALRFLSPLQSLVLDNIQIYILGFEIYFRQKNYSQALKCILNAQKLDLYHPELHLQIIYFKKNFKNILESQDVEEITQKKNEIFSTDITEYDLNEEFYKYTKNFSAYHVLSYIKSLVLINELSHLEKAIVQLLSFDNIVVFREAFDIVTEDRLKSLFKKLILAKFPLATGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7PD06</accession>
    <name>M7PD06_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anaphase-promoting complex subunit 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00192</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872055.1">
        <property type="nucleotide sequence ID" value="XM_007873864.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7PD06"/>
    <dbReference type="GeneID" id="19893890"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00192"/>
    <dbReference type="eggNOG" id="KOG1858">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000746_0_0_1"/>
    <dbReference type="OMA" id="CHRRMSE"/>
    <dbReference type="OrthoDB" id="26401at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000400">
        <property type="entry name" value="20S cyclosome subunit (APC1/BimE), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024990">
        <property type="entry name" value="Apc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049255">
        <property type="entry name" value="Apc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827">
        <property type="entry name" value="MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12859">
        <property type="entry name" value="ANAPC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 N-terminal" evidence="6">
        <location>
            <begin position="30"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 N-terminal" evidence="6">
        <location>
            <begin position="196"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1587" mass="179616" checksum="1EC6C77528BE926F" modified="2013-05-29" version="1">MVFEIAPEDLGIHRPAGFWYCFENGIATESVEWNVIQDFPYLDEELLITENTVIWSVSGHVKRSFDFCDDGQKVTHALFTYFVNPNDKIVDRHDSSYVPPLGTRTRSLNQLNASVHDSRQSGTKEFVKDLSPRLSRALVVILEDLAHIFSLDGALWVIHVPFRVRRVLAAPRGLILERSLENLELGIRPYETLFTAHSPRFFSLIGPLDEFGLVVTDGIYSFGAHDELVYIGKGDDALLVTRNPEKKQIDIWKCSYAAQTEHYHPRPMTGASSSRRRSSFGSSNYNDGDADIYGTSLKSELNITLDRMAFVNNNQLPALLGESEGLRKEIFVTHIESFPSHCTKHTFTVFSIRPSPGIEVVSIFNKEESSLLILTFRRDEGFSPYLIDSVTIPAIGAAPLISKSMEKILIFSIKKPILKLSAPCSPDIEVKINYTKEEIIELVHPVGCKVSLKRSDGTLRRIFFDLEYKTVLVQKCFEAFKVILPYRDFEYFHAAFLHQKSDNSNFHEFKSFSVILFSCFLSGSIQPRHIQNKIDGNFSNEIIEVIIEANSFCQRNDMSIMRKHLSSILQCLHILSEDFKFDSATLLYCRQIIPVKAQMAYWLGWSAFVEKDILYDEFMTTIVFDKVRLEHLNVPQFPSEPYSVYHNLILMLKEKKYVPVPSIMNIAKTDLEYKNLNYIQGSKTISLLSKTIFSLYETLLNPKLPLQDVVTQMVEHKFTLDHLKRLPDAVSIPLRDAIRYSQENPLPNWGVEALRLIDRKDLEYHITVGDERPRRFPPTLSVKIPEPKDTKAICQEVLDPEIHISFDRFSEEDHKFVTKLIFREDRRLQEVSKLLQISKQAVARIDLRPEMSEHEIVVVQQTLAQIIAIRTLSIPVGRGLYFYSSKTPLPTEKFPIPGFNFTVKIKPLQVQVPVVKSFLDDQTTTWGLFHNGTAAALSITNDTKDISASWIVYNKPNELSNRHAGFLFGLGLNGHLKSMATWHAFNYLTSKHTMTSIGLLLGLSASFIGTMDPTITRLLSVHVLALLPPGSSELNLSTLTQTAGILGIGLLYYNTQHRRMSEVLLMEISKFSPPGQEFRDEGYRLSAGFALGLINIGKGQNLKGLQDLHIVKSLVSCISGGRHEETSQNLDMTSSGAVIALSLIYLKTNDEDVAKKIEIPATEHLLDYVRPDILLLRVLAKNCILWDKIDSTFEWIKNQLPPILRDEVLLTGKTSLDSNDMALFNIISGACFSMALRFVGTRNENAKKCLLHFLDKFMNLSTLIASTHDQKLCKTTVKNCLDVLCISSSCVMTGSGDLDVLRRLRKLHGRTDADITYGNHMATHMAIGILFLGGGQYSLGNSNLSIASMICAFYPQFPNSAWDNISHLQAFRHLWAISCESRCLIARDVNTLRPTLVPIASDSSYTFYDAKNAVAPCLLPPRDDISIIQTLSPQYWQASLALHTTPISPQKTSTMYISKRVMDSQECFNLEPLSQPSIERSILKMFLSESLLSNEFYSMISRLELSSQFIIDRALQQNEAINSKLLLLSDIKKENSAKLYGIQLLLVYAENISTGLLTSKYSGFRNRFLSDDFLSLLRLRTWNASQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M7PD58</accession>
    <name>M7PD58_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875290.1">
        <property type="nucleotide sequence ID" value="XM_007877099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PD58"/>
    <dbReference type="GeneID" id="19896913"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03226"/>
    <dbReference type="HOGENOM" id="CLU_1200269_0_0_1"/>
    <dbReference type="OrthoDB" id="5371389at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="231" mass="26687" checksum="EE3E55737936532A" modified="2013-05-29" version="1">MMYRYYGSVSRGNIVKKLLNRGIRRRVMIWGMGCLGAYFFPIIMSGILVLLTGVFLSRVFQSIFNLRYQKRFINNIFPFWNAGKYESLLSNLFKPLVSYIIPDTGSLAEKLYINSIKRIERAIEVNESEISYILGTRKVSFEQYESFSMIGINNLSKFSINFKMLDFYTRNEIALASSYGVMDEYDKSAVLEKILITTNDNEKIILYGDIISKKGQGKTIDAEHWTTKSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7PD78</accession>
    <name>M7PD78_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_03245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875312.1">
        <property type="nucleotide sequence ID" value="XM_007877121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PD78"/>
    <dbReference type="STRING" id="1069680.M7PD78"/>
    <dbReference type="GeneID" id="19896932"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03245"/>
    <dbReference type="eggNOG" id="ENOG502RV3A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026590_0_0_1"/>
    <dbReference type="OrthoDB" id="5577209at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14364">
        <property type="entry name" value="CUE_ASCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052586">
        <property type="entry name" value="ASCC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041800">
        <property type="entry name" value="ASCC2_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21494:SF0">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21494">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2 ASC-1 COMPLEX SUBUNIT P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="315"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="569" mass="67390" checksum="21A53F296590B3FE" modified="2013-05-29" version="1">MHITGYPSRDLRVQIAEDEWKYALDMWIRCIEYFMGISDAEFECLLDDVESESLYIFIKNYLDAHTPRKCVKLLDNIDNEEDDLLEKNLFSLLYRIFTLERPTTHIFKIPFVIFDFCTLFGFSSATCVYFALENVYKYAKKEVFLQIQNVYENFRELMDKLVSLKDKELLEDPMMYRVAFRSLIVFIQFCFPATCVFLQDEEFLRLMIRLYHESSVADEMKSDFLCLVYTLFTAFLSENEARLLIIKRFMWLYEQLSLETALLHDLVLDTSIVERFYEVELFSEEIMSQLRVLRENNEINNSKKSLDSSLDPSIKRLSLISHIKDIFPDYSEEFIESFLKEYCDDVEAVIARILEDSFSSNIPSVDKKASNFKLNDGGLSKHVSKMLVDQTDDTNMFVDHPKIYKGKKIFETADDILKDKSFIREYKQTILDLELLNQDDERDDTYDNVDGFINLESYEEKSSNKLMNNMDEMLYLTYIISPEVFERGSHIRRSSARIELRSKTGLSDEQIEGWKIMLDRNPKRIEKLENMFKFYDDNNLISLESDQNDKFNKNSRISQFSYKKGKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M7PDR7</accession>
    <name>M7PDR7_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AmmeMemoRadiSam system protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875146.1">
        <property type="nucleotide sequence ID" value="XM_007876955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PDR7"/>
    <dbReference type="STRING" id="1069680.M7PDR7"/>
    <dbReference type="GeneID" id="19896777"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03090"/>
    <dbReference type="eggNOG" id="KOG3086">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038085_0_1_1"/>
    <dbReference type="OMA" id="MHLPYIH"/>
    <dbReference type="OrthoDB" id="417112at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="308" mass="35138" checksum="1B5DD23230D347BF" modified="2013-05-29" version="1">MLRRASHAGTWYPSSESILINNLEKFLQIKTNRIEKNKNQKGKVLITPHAGYEYSGNTAGIGYSHMNWSDVDRVFILGPAHHVDLQECAVSSCTEYETPLGKLKIDREVVKSLIKTGYFSQMDLETDEDEHSIELQLPFIYYQLAESSPNAKIIPILVGAILPEQEHIYGCLLAPYLKNPKNRFIVSSDFCHWGRRFSYTYYAEPGQPPRQISRLNPPSLACPIYASIEQCDREGMRRIEDGNHEKFIEYLLKTRNTICGRHPISVILCALAEAEIHQKFHFLHYTQSSLCKEISDSSVSYATAIVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>M7PE47</accession>
    <name>M7PE47_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_02918</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874959.1">
        <property type="nucleotide sequence ID" value="XM_007876768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PE47"/>
    <dbReference type="STRING" id="1069680.M7PE47"/>
    <dbReference type="GeneID" id="19896605"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02918"/>
    <dbReference type="eggNOG" id="KOG0337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_5_2_1"/>
    <dbReference type="OMA" id="KMAFITC"/>
    <dbReference type="OrthoDB" id="10261375at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012541">
        <property type="entry name" value="DBP10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF8">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08147">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01123">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="226"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="743"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="744"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR08744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="764" mass="87407" checksum="BCBC3684EEF92361" modified="2013-05-29" version="1">MDVVAMARTGSGKTAAFVIPMIERLKTHQTKVGSRALILSPNRELALQTIKVVKELKRGTNLKAVLLVGGESLEEQFEMMSTNPDIIVATPGRFLHLKIEMDLDLKTIEYLVFDEADRLFEMGFSEQLSEILRYLPSSRQTSLFSATLPKSLVDFAKAGLQNPILVRLDVESMVSEDLQSAFFSVKSSEKEAALLYLLHDIIKIPRSIQGIKDNNLEENGKDNTCKYNQNTISPYSTIIFTSTRHHVEYLTKLLSLSGYLVSHIYGSLDQTARKNQIASFRAGKTTLLVVTDIAARGIDIPLLSNVINYDFPPKPKIFIHRVGRTARAGQKGWAYSLLKTDDAPYLIELQLFLGKKIVSSNDQDPDYVQNIVLGTFLRHKLEYYCEWIAHVLKENNECYSLKQVMQKGEILYSKTAGSASIESNRRAKELVKSLEWSIINPLLIDTNSEKNVAKEALLAKISNYSPHETIFENSKNFKSNVPLKAINERMKKIRTSKIKTNKSNLIESLFNKKKNSKTNNDTIININNFQENNAEFGSEIIHENGVKNKGNSYKDKENYMSYYTPISSMREHAYDINKSNYSFEKAAKNAIFDLMGDDKDLTNQARAHTNKIRWSFKKKKLVNRINDYNNSKEGSKIIKDESGTKIPATYKTGRYTIWKNSKNITEKKVGEIENCENFTTPKNLHVNPNGRKYKHNKLQAPKAADKYRDDYKKRKKRIQKALEKGYGDNKRVKSELKNIMEIRKIRRLKEKRKQKNARPSKKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7PFA0</accession>
    <name>M7PFA0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_02482</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874491.1">
        <property type="nucleotide sequence ID" value="XM_007876300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PFA0"/>
    <dbReference type="STRING" id="1069680.M7PFA0"/>
    <dbReference type="GeneID" id="19896175"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02482"/>
    <dbReference type="eggNOG" id="KOG1165">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019279_1_1_1"/>
    <dbReference type="OMA" id="GRGWDYK"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14127">
        <property type="entry name" value="STKc_CK1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000160">
        <property type="entry name" value="Casein kinase I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="18"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="390"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR09139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="432" mass="49489" checksum="96D8D2417338BCAE" modified="2013-05-29" version="1">MTTSTHSTQLSNVVGSRYRVKKKIGEGSFGVIFEGIDMFNNQQVAIKFEPRKSDAPQLRDEYRTYKLLVGSLGIPHVHYFGQEGLHNILVIDLLGPSLEDLFDWCGRRFTTKTVVMLAKQMLTRVQTIHEKNFIYRDIKPDNFLIGRPGTSNSNLIHIVDFGMAKQYRDPRTKQHIPYRERKSLSGTARYMSINTHLGREQSRRDDLEALGHVFMYFLRGGLPWQGLKAMTNKQKYEKIGEKKQATLIEELCEGFPDEFSQYILYVRNLGFEDTPDYDYLRGLFTNVIRKIGETEDGEYDWMLLNDGKGWEASSKHVSSNQHLVVSNVAHKSTSVTDLRHLPSSRTGQHVSSNRLNPSHCIPPSPIPVHNGLKPCKERLNDIKNNSEHMKEISNTSPRIHQESQQQSRLSQAYATTPAKKSKKSWRFANCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7PGA3</accession>
    <name>M7PGA3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_02066</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NSE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874047.1">
        <property type="nucleotide sequence ID" value="XM_007875856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PGA3"/>
    <dbReference type="STRING" id="1069680.M7PGA3"/>
    <dbReference type="GeneID" id="19895760"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02066"/>
    <dbReference type="eggNOG" id="KOG2979">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1031049_0_0_1"/>
    <dbReference type="OrthoDB" id="26899at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16651">
        <property type="entry name" value="SPL-RING_NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026846">
        <property type="entry name" value="Nse2(Mms21)"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330:SF1">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11789">
        <property type="entry name" value="zf-Nse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="11">
        <location>
            <begin position="168"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR09479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="270" mass="31586" checksum="161D8FA57B654670" modified="2013-05-29" version="1">MESTNNNININDDSNNSYTSLDIKDLYKIELLYSEYTSIMNYIIQCCNILTDSAILKNLIDSEKSNSLEDKKLEEALKSLIDSMAYIKLQENILSQISKESNKDINLELKFQELYMKKKKEYDSLSSSQKYSKKSEYIDFKQRILNVHRKNARTLTTESIFKETFISDDEDIVISYLDQNIKCPLTMSYLEEPLKSNICGHYFSKHAILEILKFNNGKYICPIVGCNKIIDNTVLVPDKIMERRINIAKEFEKDFDESEENNRSKYINLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7PGP4</accession>
    <name>M7PGP4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_02213</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874196.1">
        <property type="nucleotide sequence ID" value="XM_007876005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PGP4"/>
    <dbReference type="STRING" id="1069680.M7PGP4"/>
    <dbReference type="GeneID" id="19895906"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02213"/>
    <dbReference type="eggNOG" id="KOG1783">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_7_5_1"/>
    <dbReference type="OMA" id="EQTVEYV"/>
    <dbReference type="OrthoDB" id="268799at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01726">
        <property type="entry name" value="LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000044">
        <property type="entry name" value="Probable U6 snRNA-associated Sm-like protein LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF1">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10 13" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8 13" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Sm" evidence="14">
        <location>
            <begin position="7"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR09629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="77" mass="8521" checksum="B86D1FA65EAD9C5F" modified="2013-05-29" version="1">MDSATDAPSAFLQKIIGHFVLVRLSSGIDYRGILSCLDGCMNVALEECREYVKGVLKNEYGDAFIRGNNVLYIECDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7PH09</accession>
    <name>M7PH09_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Histone chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01924</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CHZ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873900.1">
        <property type="nucleotide sequence ID" value="XM_007875709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PH09"/>
    <dbReference type="STRING" id="1069680.M7PH09"/>
    <dbReference type="GeneID" id="19895618"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01924"/>
    <dbReference type="eggNOG" id="ENOG502RIST">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2185088_0_0_1"/>
    <dbReference type="OMA" id="IMCSTRT"/>
    <dbReference type="OrthoDB" id="2506169at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019098">
        <property type="entry name" value="Histone_chaperone_domain_CHZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09649">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone chaperone" evidence="7">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="109" mass="12407" checksum="8B30B8FA4BAC2158" modified="2013-05-29" version="1">MQETVESPCDQYELKKKEKTSELIASSAVLQEDDDDLEDDSSEDELDDENDLEEIDEEDVTEDDMAEIDPSNIIGASRTRGKRVDYVKDVISDDILEDDEEDTDFNVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJ86</accession>
    <name>M7PJ86_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein-sorting-associated protein 25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ESCRT-II complex subunit VPS25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01229</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873148.1">
        <property type="nucleotide sequence ID" value="XM_007874957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJ86"/>
    <dbReference type="STRING" id="1069680.M7PJ86"/>
    <dbReference type="GeneID" id="19894926"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01229"/>
    <dbReference type="eggNOG" id="KOG4068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087657_0_1_1"/>
    <dbReference type="OMA" id="TRCLIMW"/>
    <dbReference type="OrthoDB" id="245150at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000141">
        <property type="entry name" value="vacuolar protein-sorting-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.570:FF:000003">
        <property type="entry name" value="Vacuolar protein-sorting-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.570">
        <property type="entry name" value="Winged helix' DNA-binding domain. Chain C. Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008570">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014041">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05871">
        <property type="entry name" value="ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="193" mass="23112" checksum="9D96C65A20573D8A" modified="2013-05-29" version="1">MSKNCLKNDEENIIFEFPSLYEFPPFFTRQPNAETWKSQQSHWVSLILKYCQCKRIFRLHISKELLEEELFFNRKIHRQVKMDMLKEILDFMVSKNNGEWLCSGKKDMFLVYWKTLDEWADMIINWIEETGQRNCVLTYYELIEGKALINTELYKIDPIILKKAIAILVKKDMAQVLRGANENEFGVKFFGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJM7</accession>
    <name>M7PJM7_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873293.1">
        <property type="nucleotide sequence ID" value="XM_007875102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJM7"/>
    <dbReference type="GeneID" id="19895061"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01364"/>
    <dbReference type="HOGENOM" id="CLU_691026_0_0_1"/>
    <dbReference type="OrthoDB" id="5406529at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="399" mass="46382" checksum="010F176A1805F77E" modified="2013-05-29" version="1">MRFNEAKSSSPDPLDILSSSKPLYLTPNCRQSLNLSHQKLELSTEIRRIGLYVDIGSDREEVFFVSPKKTSKHTGIKTSTKKSCEIKDEGNSDISFNEIVSSCKKILDGKKKGKKKPIKQKRKTSNTQCLNTNLAFMQDVENILEAEPVKEAEIKHFDEEDTCLYNNMIFRERKNVIENHFYFDKDVMDVDNPEIISSNSTNELVKKSNNYTTNFKKLSSKKRLNIEKKEKMPNTTKILDSADAISEPNISIEPALSLFPKKNVLIEISSLSKASAERAANALTLTGRFEFESIQNQEDSDKCQEIFQEKRCWTKDEWKLLELLLIKHKKIKKTLDCFLKVNSDFSEEEVDKRLKVLLFKKKENYYLNIDKKNKLNNHIEVRNNKVSNSVFEWKNWLKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7PKU1</accession>
    <name>M7PKU1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-rRNA-processing protein IPI3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00688</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the WD repeat IPI3/WDR18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872586.1">
        <property type="nucleotide sequence ID" value="XM_007874395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PKU1"/>
    <dbReference type="STRING" id="1069680.M7PKU1"/>
    <dbReference type="GeneID" id="19894386"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00688"/>
    <dbReference type="eggNOG" id="KOG0646">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029749_0_0_1"/>
    <dbReference type="OMA" id="GVNARIY"/>
    <dbReference type="OrthoDB" id="756370at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 5 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="121"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="282"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="453" mass="52126" checksum="B5634D4C81A64DFF" modified="2013-05-29" version="1">MNQGNFQEIIVIGYKNEKLVDDTYIYVYDLYTGCQIMKFKQNDCCLKGIFITEKYIFSSQREKPILHIYSWQKESIFQKIILPETLTAFAVSHDVYWAVGGTLQGKIYLWQISSGNLMFVHDAHYQKITAITFVMHDSFFLTGSEDNHLCLWRLLDIVDLYSKKEGCPVKTWNDHSLAITDIVCGFGTANSARVFTSSLDSTVNVWDLSTQSLLTTFVFPKPVTCLAIDPAERAFYAGNDQGDVYLVDLYGFAEEKSLESFYEAIGGSKKVIQSVNDESTIFKGHKNAISCLTLSFDGSLLISGSQDKDVFLWDIATRQIIHTFSKQDGPITSICCKVIYRGFFENKISLQNIPTFKKIQNFQDMNDYSILKNLHVFNELKNKTAWYEDDLTLMRKDLSEFSSIASESVLQLYIKNLQNELQTLYGYYSDLREVHQELWKEYMKSQIVDHDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7PKV9</accession>
    <name>M7PKV9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleosome assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00706</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872606.1">
        <property type="nucleotide sequence ID" value="XM_007874415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PKV9"/>
    <dbReference type="STRING" id="1069680.M7PKV9"/>
    <dbReference type="GeneID" id="19894404"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00706"/>
    <dbReference type="eggNOG" id="KOG1507">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038841_1_0_1"/>
    <dbReference type="OMA" id="AAECKQN"/>
    <dbReference type="OrthoDB" id="27325at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032174">
        <property type="term" value="C:cellular bud neck septin collar"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990317">
        <property type="term" value="C:Gin4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000511">
        <property type="term" value="F:H2A-H2B histone complex chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007117">
        <property type="term" value="P:budding cell bud growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031116">
        <property type="term" value="P:positive regulation of microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098841">
        <property type="term" value="P:protein localization to cell division site after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.90:FF:000003">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1500:FF:000001">
        <property type="entry name" value="Nucleosome assembly protein 1-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="18"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="365"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="365"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="411"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR11109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="48190" checksum="3B2B6E4A93ABCF62" modified="2013-05-29" version="1">MSENLNIYNKKVMDHLAPTPQNTPAGNNISIISGSNVSSSSPAPVVSSAKDDREDPPISTHSALSRAPGLISMIQGKLGSLVGQSSGYIESLPLAVRVRVEGLQGLQVQHSKLEAQFQNEILELEKKYHDLCSPLYNRRSAIIIGAIEPTNDEIEAGREFGKIYDTDNKKCDVENKSYGSDENVKGIPQFWLTAMKNFPSLAEIITPEDEKALCYLVDIRLAYLDKPGFRLEFYFADNEFFSNKIINKTYYYRAELGYGGDFVYDHAEGDKIDWKTGKDLTTRVEIKKQRNKNTKKTRVVKKVVQTESFFRFFAPPVISDIQNVDDSDIDNRLEADYQYGEDIKEKLIPRAIDWFTGVALAYEDEYSDDSDQDYTDEDGNDDDDDNDDDDDDDDDDNDDDDDNDNGNNLGGKDDNKPKHDPVECRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M7PL03</accession>
    <name>M7PL03_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase PEP5</fullName>
            <ecNumber evidence="9">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_00745</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex. Component of the class C core vacuole/endosome tethering (CORVET) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the VPS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="9"/>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872646.1">
        <property type="nucleotide sequence ID" value="XM_007874455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PL03"/>
    <dbReference type="STRING" id="1069680.M7PL03"/>
    <dbReference type="GeneID" id="19894443"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00745"/>
    <dbReference type="eggNOG" id="KOG2114">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001287_0_0_1"/>
    <dbReference type="OMA" id="ENENECP"/>
    <dbReference type="OrthoDB" id="26184at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033263">
        <property type="term" value="C:CORVET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16688">
        <property type="entry name" value="RING-H2_Vps11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057308">
        <property type="entry name" value="CHCR_PEP5_VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057307">
        <property type="entry name" value="PEP5_VPS11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016528">
        <property type="entry name" value="VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024763">
        <property type="entry name" value="VPS11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23341">
        <property type="entry name" value="PEP5_VPS11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23356">
        <property type="entry name" value="TPR_PEP5_VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12451">
        <property type="entry name" value="VPS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17122">
        <property type="entry name" value="zf-C3H2C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007860">
        <property type="entry name" value="VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0926">Vacuole</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="CHCR" evidence="11">
        <location>
            <begin position="404"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="869"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR007860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR11149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="958" mass="109677" checksum="49331BC8A754BBF1" modified="2013-05-29" version="1">MDLSSWRQFNFFKITEITNLYHKKDGQDVLKIISSSIVTSGRKYIYAADNFGYIRIISSEFDIVYEFSAYKNGHVILLHCISEAPLLVTIGDEENNSNPILKIWSLESFESSLKAPKCKTTININSNANPYPISCFAVSENVGHIAIGFANGTVLLIKGDLVRDRGSIQRVIYKSEEPVTGLYFKESKKEISLFIITTGKVLKLLINAKIQLKSPEIIDAVGASLGCSTINRKNNDLIIVRDDSIYIYKSNNKNICYSYKSSKFGVLVNHDYVFVFLLPCAASIIAPSTTNISPRNIFDMSQLIIINTENKFIAHVSNFQFFLKTIFMEWGDVYIFSQDEQVFRVQEKSITEKLEILFQKHSYPLAIDLALTGGYTRVKVNDIIIKYGDYLYDNGDFDGSMKQYILSIDQIKPSNIIKKFLNSKHINNLISFLEALYTKRLSNSDHIILLLNCYAKLHDSEKINDFIMKENVEFDITSAITIFRQGGYFDQAAYLANKYQDYDTYLSIQIEDKNDCKKSLEYILDLEPEYVFFCLKKYGKKLLTEVPLEVVSLCIDLFSGTYIPISKKSSLKKSTSQTTQFAIANYVPFLPYVNTNTASSTSEQSIVSSNQTYSCNIKTLPTYAIPSVSSIFPIFINNNKQLIYILEILMEKFSAIDDKNSERDLVCITLYEIYLREIKNSHSSIERQDYEKKAKSILDNEICLIDSFNGLLLSYLTGFSEGFQILKEKSDTKIDAFRYYCSIEDTSKVIDFLAKHGDSESELYLLALGYFISSPRILDDVGDYFHIVLKKIKEERLMTPLEIIKILSLNSIATIGVVREYLIEIIEQERKEIDNNSKLINTYHNDTENKKNKLNDLMESAQILQGMKCSICELTLDLPVVHFLCKHSYHQRCINDLEEMEYCPQCSSNNNMIKAIKKSQSEIANKHNFFQSQLENATDKLKFIFDFLSRGALSMEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7PMK9</accession>
    <name>M7PMK9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF726 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00138</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871999.1">
        <property type="nucleotide sequence ID" value="XM_007873808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PMK9"/>
    <dbReference type="STRING" id="1069680.M7PMK9"/>
    <dbReference type="GeneID" id="19893836"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00138"/>
    <dbReference type="eggNOG" id="KOG2385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001695_2_2_1"/>
    <dbReference type="OMA" id="KFAYIGI"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF3">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="594" mass="66584" checksum="D09CAE5BAAAE2A50" modified="2013-05-29" version="1">MVYVNKKICIFFIKTKKEQVMIEQLSEHGIETSDITSVLMATTQIHNPFINIPENCDNSNDDKSPFFISNINTDEDKLDINDKKVLDLDIRWAILCDLFLILVADSIYDSRSRVFLERVGKAISISALDITIFEKKITDELIIQENFEASKSDQSVLELRDKSSRNKRYILMGLATISGGLVIGLSSGMLAPLIGAGLGAAFSTIGVAGTTGFLVGTGGTALITTGGVVTGSTIAVKKMSNRIKSIKVFEFKPLYDNKRLNLLIAVPGWMLKNDDVRLPFSTIDPIMGDVYSILWEPEILQSVGKTINIIATEILTQSLQQVLGQTVLVTLMSALQWPLILTKLGYLIDNPFVTSLQRAKSAGFVLADILLHRKLGIRPISLVGFSLGSRVIYYCLLELARKQAYGIIQNVYLFGTPVVIKENNWILASSVVEGRFINGYIKNDWILGYLFRITYGGIGHIAGLQPIQKISTIENIDVSDLVDGHMNYREAMPKLMKKVGWLIESEEFQEIEVPDPDKHRERQKELLESIEMAKKNSKNEKVTKNSYLKKFNLFQKKKKVDMNYNSNNDKPIRFNSLNTPSKAYDLFSSNVKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWY8</accession>
    <name>A0A0W4ZWY8_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_04313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="KTW32882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613356.1">
        <property type="nucleotide sequence ID" value="XM_019757829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWY8"/>
    <dbReference type="GeneID" id="30671592"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04313"/>
    <dbReference type="eggNOG" id="ENOG502RY79">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5411930at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033481">
        <property type="entry name" value="Dni1/Fig1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28092">
        <property type="entry name" value="FACTOR-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28092:SF1">
        <property type="entry name" value="FACTOR-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12351">
        <property type="entry name" value="Fig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KTW32882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="210" mass="24016" checksum="A8547EB3D9E203B5" modified="2016-03-16" version="1">MGCTSAKMHSIYIFEIEHKNMNIVSIFNDTDILDIINQENKNIFDIRVGYNGICTIRPDDIMCFKNFNSFTEKFNDSSEFISISDAFLDEFQYKKIAIGTCILIGASLFLSLFNSIPFIPHFHLLTLLNFYFILSGTILLITLTFIVHITISSLCSISRDLNTTIIKINPGINLVILSWVSCIFALISTTDFLFILHMKSKKIIQKKNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZX31</accession>
    <name>A0A0W4ZX31_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major surface glycoprotein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_04004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="KTW32925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613394.1">
        <property type="nucleotide sequence ID" value="XM_019757763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZX31"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZX31"/>
    <dbReference type="GeneID" id="30671540"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04004"/>
    <dbReference type="OrthoDB" id="5423421at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003330">
        <property type="entry name" value="MSG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02349">
        <property type="entry name" value="MSG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="761"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="761"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="810"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="854"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="886"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="912"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KTW32925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="935" mass="106453" checksum="ACC1D8F1A1D8AE85" modified="2016-03-16" version="1">MAQPVKRQAAGQAAGNDEIKEEQVLGLIVKSGYNNDNKCKANLKHYCEELKKIDGKLESVDVKVKGLCENGKEEEKCKSLKDKVKTELDAFKTEVENALNNLTDEKCRKYEEKCLLLEEADPNNLEEKCVKLRDRCYRQRRQGVAKEILLRALEGKVNDTNECKKKMKEICQGLSEYSDELVFSCFNPDETCEYFRKNHGDNCKPLQKELEDKELVEKCQEYLEKCYFYGSSCKDTKCDKVKNKCKGKGIEYEGPKLDFSPVKEKPRFPEKIEVENLYKKEEAKGIIVGKPKYKTLRDLALLLIKGRNGNSPEEKCKEALKDCESFKHLDYGLEELCGDKDKEDRCKELVEVEDRCTNFKLELYLKGLSTEFEKDKESDYFSWGQVSKLVSREDCIKFESECFHLEGVCTNKIGKACENVRVACYKKGQDRVLNRYFQEGLKGLIGDLELVTENLEKCQKSVVGNYTKLKEDRRYFTKCHLPTKLCYELLDDVILQSEELEVVLNLRRDFPRKEDCVELKKKCKDLESDSYLNHEKCDTLNRRCEYLKVTEELRKKLLKRGDDALRTQGNCTAVLKKECEELSRRGKEDFSVSCALREETCSFMVEQTENECLFLKNNMDIGKIIEKIENGKRNETLVEELCTLFDPYCHQYIENCPDRLKKAKNSGKKGVCLELEEKCKPFFEKLKLENELTHKLKGSLSDETKCKETLGKHCTEWKKEGNQTLNSLCEDAKKEELCKKLVKKVKEKCPTLKNKLDNEKDELEKKKDEYEKAKQESEKFAKEAKLVLSRPEQDGQGGGSKAQDGSVPKPVGPPVQPPAPAQPTPGGVPAPTLAPPAQPTSGGAPLPVPPAAPAAPGAPSTPGTPAAPGTPAASGTPAAPGAPAAPEEHQEHQQGQQHHQEEHHRVTSSTTKWDHQHDQHYSRLENNWNEKRSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZX36</accession>
    <name>A0A0W4ZX36_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_04264</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="KTW32927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613396.1">
        <property type="nucleotide sequence ID" value="XM_019757787.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.A0A0W4ZX36"/>
    <dbReference type="GeneID" id="19894542"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04264"/>
    <dbReference type="eggNOG" id="KOG0379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HRADHEH"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000049">
        <property type="entry name" value="Cell polarity protein (Tea1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="345"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="402"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="553"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="612"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="738"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1019"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1128"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KTW32927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1295" mass="147441" checksum="1359B0C716B5027D" modified="2016-03-16" version="1">MNKESSYPWYRQKILGPCPFPRYGHASNSTVSKTGDIYIFGGLVKEKVKHDLWIIDSATMMSYQIQTPGDCPSSRVGHAGLVIGNAFIVFGGDTKTSKNNVNDNSLYLLNTTSKIWTKALVYGNKPPGRYGHTLNILGTKIVIFGGQMEIYFFNDMFLFDLDTLNTLNAKWELITPVTSLPPARTNHIMITYQEKLYLFGGTNGTQWFNDVWVFDYKNLSWKEIACNGCIPQPREGHSAALVDDIIYIFGGRGLDGSDLGDLIAFKISTSRWYIFQNMGPSPSPRSGHVLTSFGQKIIVLGGEGSLSKVEDSSITYILDTSKIRYPPEISIPNLGSSPMIKSGSLLAPSPLSPMPQKALSMSSSKLNQGSKSPLGVTAPSKLLQHSESLRTDMQTMSLEQFHKQRISRKHNRSKDLSTSFKEESNSLHHSNSVNNLQLSRSQSQDQIKKITVNDIKLNTDQTNNNNQNETKPVSAMDENQIEDIELTKEKNLNTDNSQANNKDMQHSKFKENIDELKVKNELLQAELDLIKSPDLEKSSTEITLLKLEILSQTKAASLKIAEAEAEKNNCLQEAAYYKAKLAALSTPEILSTVENARISELSTKLSNTITSRQELNEKLTSLSEDIVLEQRKVQQLEDMNQNYLKRIKVAESAHERISTELNEIRLACINAEEKIKEQVSLKNNLECEKNQLNQENIALKQELDDLKEKNMLYLKSIEMINISVSMAENRIANSESKSQKDQEARVELQNKVNQLTRELMLESNKKQALEEKITNLESKILNITKEANVAREIMNEGILELLKKSRETSSSNSLNDNQIKMLQEQLASIKSLYSALQVSANKSVKDLVAALEKISQLETLNFSSNREIQDLRDKMLDLLKELDALKKDHRNMKILLTTKDKDLEIAHMKASAISRLLEEYPLLEEQKISKNDAVSCVTRGTSMTPDALNKDNFKKPEEALEQNNHIKLEIEKSDDLDVSDLENTESKTLNDKVIENNSKSYKDTPSDNISSINLEKEALDLERQKVIDAERRLAESTQNFKERLQQLESDYQSAVFYMKSTENMLKRMKEELSKYKIQNFHLKQENDNLKNYRNMTILNFKDHKIHDNEMQNNSFNHDYAEIQAHKDILLQEKELESLEEKYINLKNTYYDNNKESTDIIFPELEKTIDLETISKNKNLIFENLSNDQLIFSDKISEDNIIPNLEDLSNANNYIIDSMENDSIFLKESEQLIPIDHYNIHESTSLNSDNITKNATFKESVFSRTSDTLDSLANELDQLRTQWESTHKDYETLLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M1FNY9</accession>
    <name>M1FNY9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">NADH-ubiquinone oxidoreductase chain 4L</fullName>
            <ecNumber evidence="4 13">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">nad4L</name>
    </gene>
    <organism>
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="14"/>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2013" name="FASEB J." volume="27" first="1962" last="1972">
            <title>Sequencing and characterization of the complete mitochondrial genomes of three Pneumocystis species provide new insights into divergence between human and rodent Pneumocystis.</title>
            <authorList>
                <person name="Ma L"/>
                <person name="Huang DW"/>
                <person name="Cuomo CA"/>
                <person name="Sykes S"/>
                <person name="Fantoni G"/>
                <person name="Das B"/>
                <person name="Sherman BT"/>
                <person name="Yang J"/>
                <person name="Huber C"/>
                <person name="Xia Y"/>
                <person name="Davey E"/>
                <person name="Kutty G"/>
                <person name="Bishop L"/>
                <person name="Sassi M"/>
                <person name="Lempicki RA Kovacs.JA."/>
            </authorList>
            <dbReference type="PubMed" id="23392351"/>
            <dbReference type="DOI" id="10.1096/fj.12-224444"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Mitochondrion inner membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the complex I subunit 4L family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="4 13"/>
    <dbReference type="EMBL" id="JX499144">
        <property type="protein sequence ID" value="AFR90412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_007475002.1">
        <property type="nucleotide sequence ID" value="NC_020332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M1FNY9"/>
    <dbReference type="STRING" id="1069680.M1FNY9"/>
    <dbReference type="GeneID" id="14657951"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030964">
        <property type="term" value="C:NADH dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3510:FF:000004">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase chain 4L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001133">
        <property type="entry name" value="NADH_UbQ_OxRdtase_chain4L/K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004320">
        <property type="entry name" value="PRK05715.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434:SF16">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT ND4L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="13" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 13" id="KW-0813">Transport</keyword>
    <keyword evidence="13" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFR90412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="88" mass="9755" checksum="A498BB581EABED09" modified="2013-05-01" version="1">MSLSLTLFLIGLLGFILHRKNIFLMLMCIEIMLLSITLLIVVSSQAMDDLIGQCFGLYIIAIAGAESAIGLGIIVSYHRWRESIVIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NHK4</accession>
    <name>M7NHK4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_03490</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875580.1">
        <property type="nucleotide sequence ID" value="XM_007877389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NHK4"/>
    <dbReference type="STRING" id="1069680.M7NHK4"/>
    <dbReference type="GeneID" id="19897177"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03490"/>
    <dbReference type="eggNOG" id="KOG2784">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025086_2_0_1"/>
    <dbReference type="OMA" id="QIEGWVM"/>
    <dbReference type="OrthoDB" id="238316at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000028">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003210">
        <property type="entry name" value="PRK04172.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="279"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR08048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="502" mass="57831" checksum="CC894BE285B59C7A" modified="2013-05-29" version="1">MEGSDELKTLILNTLYNGDIEDTLMLRLNGEKEAIDQQKIQGCLNSLVSKEMVTYKIIEKEYFILTEEAKDIVLNGSYEAKIFNLICSSINGLTLEELESIMGPSIEHGLKQVFKNKWVKKVGSNLVKNVDSITDTVAHNLKIIQENGTHSDSSVIIELRKRKLLEKNKQISFSVKKGPKFSLSIKKQITDLTVEILQSKLYESMEFKPYNFDAKGTNIPSGSLHPLLKMREEFRSIFFELGFEEMPTNKFVESCFWNFDSLFVPQQHPARDLQDTFYIKTPRLSKPMQEKQYVEAVRRIHEEGNFGSIGYRYPWSLEESRRLVLRTHTTSISAFMLYKLANQEGGFTPAKYFSIDRVFRNETVDSTHLAEFHQVEGVIADYNLTLGDLIGFMDLFYSKMGVKNLKFKPTYNPYTEPSLEIYSYHEGLKRWVEIGNSGLFRPEMLEPMGLPKDVRVYGWGLSLERPTMIKYRLNNIRDLLGHKVDLDKIQASPAVRLSEGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NIB7</accession>
    <name>M7NIB7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_03141</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">The mitochondrial prohibitin complex consists of two subunits (phb1 and phb2). The subunits assemble into a membrane-associated ring-shaped supercomplex of approximately 1 mDa.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875201.1">
        <property type="nucleotide sequence ID" value="XM_007877010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NIB7"/>
    <dbReference type="STRING" id="1069680.M7NIB7"/>
    <dbReference type="GeneID" id="19896828"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03141"/>
    <dbReference type="eggNOG" id="KOG3083">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047969_0_2_1"/>
    <dbReference type="OMA" id="YEFRLVT"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035632">
        <property type="term" value="C:mitochondrial prohibitin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140580">
        <property type="term" value="F:mitochondrion autophagosome adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045861">
        <property type="term" value="P:negative regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="4">
        <location>
            <begin position="25"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00065366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="280" mass="30933" checksum="BAD1AD5C1CE3FA70" modified="2013-05-29" version="1">MAHILDKLSRLAIPIGFSLAIGQASMYDVRGGSRAVIFDRFVGIKKEVIGEGTHFLIPWLQKAIIYDVRTRPRNIATTTGSKDLQMVSLTLRVLYRPDVVKLPKIYQSLGLDYDERVLPSIGNEVLKSIVAQFDAAELITQREIVSSKVREDLVKRASEFGIQLEDVSITHMTFGQEFTKAVEQKQIAQQDAERAKFTVEKAEQERQASVIRAEGEAEAAETVSKALQRAGDGLISIRRIEASKEIAAVLANAKNVTYLPGQHLGAKEGALQGANYLLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NIP7</accession>
    <name>M7NIP7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PNEG_03296</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 14">Cytoplasmic vesicle</location>
            <location evidence="1 14">COPII-coated vesicle membrane</location>
            <topology evidence="1 14">Peripheral membrane protein</topology>
            <orientation evidence="1 14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 14">Endoplasmic reticulum membrane</location>
            <topology evidence="2 14">Peripheral membrane protein</topology>
            <orientation evidence="2 14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Golgi apparatus membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875371.1">
        <property type="nucleotide sequence ID" value="XM_007877180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NIP7"/>
    <dbReference type="STRING" id="1069680.M7NIP7"/>
    <dbReference type="GeneID" id="19896983"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03296"/>
    <dbReference type="eggNOG" id="KOG1986">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008658_3_0_1"/>
    <dbReference type="OMA" id="FPPHYAE"/>
    <dbReference type="OrthoDB" id="10256289at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01478">
        <property type="entry name" value="Sec23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11287">
        <property type="entry name" value="Sec23_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.730:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000006">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000008">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037550">
        <property type="entry name" value="Sec23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 14" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11 14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="16">
        <location>
            <begin position="58"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="17">
        <location>
            <begin position="126"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="19">
        <location>
            <begin position="402"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="18">
        <location>
            <begin position="517"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="15">
        <location>
            <begin position="629"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMR08468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="763" mass="86315" checksum="1C30EB91D92964E1" modified="2013-05-29" version="1">METHTMNYDDIEETEGIRFSWNVFPSTRLENSKMVVPIAALYMPLIERPELPPVQYEPVSCKAPCRAILNPYCQVDMRGRIWICPFCLTRNQLPPMYKDISPQNLPMELLPKYTTIEYILSRPSQTPPIFLFVVDTCLEEDNLQALKDALIVSFSLVPHDSLIGLITYGTMTNVYELGYSECTKYYVFQGTKDYTTKQVQELLGLMGTSLRPQQPSLRRTQSNYGAAARFLLPVNICEFRLTNILESLQQDPWPVANDKRPQRCTGVAISIAVSLMENAFPNTGARIMLFSGGPSTQGPGMVVGTELRESIRSHHDIERDNIKYYKKATKFYENLAKKASTNGHIIDIFAGCLDQIGMLEMKSLSNFTGGHMILSDAFSSSIFKQSFQRVFNTDSQGSLQMAFNASMEILTTKELKISGLIGHAVSLNKKSPSIGEAEIGIGNTCSWKMCGILPKSAYAAYFEISDQDKQQAQMSQRGLIQFVTHYQHSSGTFRLRVTTAARSFADSSSPLIPQSFDQETAAVIMARIAVYKAEIDDGPDVLRWTDRMLIRLCQKFADYRKDDPSSFRLSPNFSLYPQFMFHLRRSQFLQVFNNSPDETAFYRHVLNHEDVNNSLIMIQPTLISFSFDQEPQPVLLDSISIKPDVILLLDTYFHVLIWHGEIIASWRKTGYQDKEGYQNFKELLESPRHEIAELLVERFPIPRYIVCDQGGSQARFLLSRINPSATHATSSYGAPSAQAVFTDDVSLQTFMDHLKKLAVTGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NKC4</accession>
    <name>M7NKC4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874440.1">
        <property type="nucleotide sequence ID" value="XM_007876249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NKC4"/>
    <dbReference type="STRING" id="1069680.M7NKC4"/>
    <dbReference type="GeneID" id="19896127"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02434"/>
    <dbReference type="eggNOG" id="KOG2102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002512_2_0_1"/>
    <dbReference type="OMA" id="LRRYMDM"/>
    <dbReference type="OrthoDB" id="2285229at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056624">
        <property type="entry name" value="WH_CYT4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF65">
        <property type="entry name" value="EXORIBONUCLEASE CYT-4, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23216">
        <property type="entry name" value="WHD_CYT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="1">
        <location>
            <begin position="469"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="934" mass="109584" checksum="5634BE2C486B1652" modified="2013-05-29" version="1">MIQKKISRLLKKIINRTCIKFIESRHRISYTNIIWRYYSCLNDDIKQRNTFKHDNVSKNQELFQKKDLFRKQEIKIRQKMIEKYGIIQNQKLVNQDTLKNMKDKEKNYIDDMINIEKNLFSISFKDISPGDLVEIRKSEYGILGIVIQKVIPSDDGFSVLLSNRKVIYCKPGDILFLIPSFFKNISNIELSDLEIINGYLSFNDSAFQNIIKSLRYFKLKSQYFYRKFLTKFDNLYQRLHHPNPDQHTYINILDLCRSEYKISKPNFIHLYAIHSLLANDPCHYVLDSRNQLYLNRYEVRPKSEVEMIKSVSHWIRIKSPEFLRFTEKTSDIIKIYREKKMHRLEDTILPRKYAFSETDLLFIKFIRQYFLERRQFQSSIYLSLVPQILKATKMYNSVLDRENALLFMEEIGAWAPWENYARFDRNLSLPGLGTSIVMDILLKKITSMSNLSPDQLKNFSLKDSFENLRHDFDQLPVYVIDDSDATELDDGISIEKKDHDETWLHIHIADPGAFVSPNSDISNFASNLVTTVFTPEKRYHMLPHLLTSSFFSLDSPLKKHSVLTFSTKLGKDGKILDFKISPAYISNIKKFSYDDIDNDVFDVSLKNISYCFSTEFPNTLATESIKQKKDKISTLDKTCIHNIYKISLLRLQYRISRGFWQYSTTSANIKLQYPKPYYISINDGPQFFQNYPSIKNIAFDLLDSPSRVMVAEIMILAGEIAAKFCIERKLPVPFRSQSIISKHQYRYKYNEILERRNFVTGRLSLKDGIELANYTGPTIISTSPNPHSSLAIDHYIQATSPLRRYCDLVTHWQIQASLKGKGNNEMPFSKEYLDSCLLLWFFKEKTSKNFGKLSTKLWVCMLLLKIGLDKLSPFHAWIWSMQDKRLLVTGIIKELGVNCKITSKEYYHNNPGDLIQIKITHIDLVDKVIYAYQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NKM7</accession>
    <name>M7NKM7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02535</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874547.1">
        <property type="nucleotide sequence ID" value="XM_007876356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NKM7"/>
    <dbReference type="STRING" id="1069680.M7NKM7"/>
    <dbReference type="GeneID" id="19896227"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02535"/>
    <dbReference type="eggNOG" id="KOG3409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067135_3_0_1"/>
    <dbReference type="OMA" id="PMVPVGW"/>
    <dbReference type="OrthoDB" id="440760at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039771">
        <property type="entry name" value="Csl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019495">
        <property type="entry name" value="EXOSC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE CSL4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10447">
        <property type="entry name" value="EXOSC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="4">
        <location>
            <begin position="77"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="197" mass="21720" checksum="8C25C777121159FB" modified="2013-05-29" version="1">MNKFIEAGKLVLPGQPISSTNATIAGPGTIIYNSVIRASIPGKVVQSLNLNGQCQISVERLLCRFSGKGSPILPEVNAFVLGRVIKIKPKEAIVSIFVVNEVVCQREFQGIIRIQDIETINKNTVKVYTSFRLGDIVRAQVISLGDQYSYYLSTAKNDLGVVFATDITGDAMYPINWHQMRSYATGIIEERKCARPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NL76</accession>
    <name>M7NL76_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">M-phase inducer phosphatase</fullName>
            <ecNumber evidence="2 10">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_02362</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the MPI phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2 10"/>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874366.1">
        <property type="nucleotide sequence ID" value="XM_007876175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NL76"/>
    <dbReference type="STRING" id="1069680.M7NL76"/>
    <dbReference type="GeneID" id="19896055"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02362"/>
    <dbReference type="eggNOG" id="KOG3772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017900_0_0_1"/>
    <dbReference type="OrthoDB" id="26523at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031569">
        <property type="term" value="P:mitotic G2 cell size control checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110032">
        <property type="term" value="P:positive regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110044">
        <property type="term" value="P:regulation of cell cycle switching, mitotic to meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072435">
        <property type="term" value="P:response to mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01530">
        <property type="entry name" value="Cdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000021">
        <property type="entry name" value="M-phase inducer phosphatase cdc-25.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000751">
        <property type="entry name" value="MPI_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF17">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00716">
        <property type="entry name" value="MPIPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="11">
        <location>
            <begin position="381"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR09418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="538" mass="61868" checksum="37170A5C926910A5" modified="2013-05-29" version="1">MDTSPLAAFCFSGNQNSCMTSISGYNEIDKSNFMVSGKKYSDKNNKFGMINLKQSSKSGNNSICFDTGSFKMSPTTSLVAELSGNFYIDKSPVPPTPRRSLLFKFSCDHQSTPALNFLKDPITPKFDSLTMGNINIATPCSSPIETMDYSPLPQKHTITAFSTEYCEAFDDQNLCSYVNPEIRDYCDIKNSKAPLNDISSSNELNNNILNSLFMVNEKSKINPSILDTNYDKENADNDQIKNDNESCDIALNDLFSNSPNPVRFSTGNVDSEFLQPFKKPLFSRYSIALEASPLSFMDNDDMDHRLVKWRRTQSLYKNSCDFLSTKYKGQENSDLCLQLSPFEFNSNDCQILPCFSIKDDRLKRIDSDIIVRLLDGHYHDQCDEYMIVDCRFEYEYNGGHIMGAININTKDALDALLLDNPKTKRCLIIFHCEYSSHRAPRLALYLRNRDRQLNMKRYPLLYYPEIYILHGGYRSFYEKYKERCEPQNYVEMDDSLHKTACAREMCNFRRNTKFLRTLTYTYGQTDAICTNTLQKDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLF2</accession>
    <name>M7NLF2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome complex subunit SEM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02082</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DSS1/SEM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874061.1">
        <property type="nucleotide sequence ID" value="XM_007875870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLF2"/>
    <dbReference type="STRING" id="1069680.M7NLF2"/>
    <dbReference type="GeneID" id="19895776"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02082"/>
    <dbReference type="HOGENOM" id="CLU_141774_0_2_1"/>
    <dbReference type="OMA" id="PEDENDW"/>
    <dbReference type="OrthoDB" id="10415121at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007834">
        <property type="entry name" value="DSS1_SEM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771">
        <property type="entry name" value="26 PROTEASOME COMPLEX SUBUNIT DSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771:SF0">
        <property type="entry name" value="26S PROTEASOME COMPLEX SUBUNIT SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05160">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01385">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR09493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="97" mass="11301" checksum="570DFF95EE76014E" modified="2013-05-29" version="1">MSIKGELDESKKKTEEKDQYNSVLTENTAEEKKIDINTLDDDDEFEDFQAEDWTEADTDLGISKDKLWDDNWDDDDIEDSFSISLRAELQKFQTPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLQ1</accession>
    <name>M7NLQ1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="21 22">Folic acid synthesis protein fol1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PNEG_03560</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19 22">Catalyzes three sequential steps of tetrahydrofolate biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19949"/>
            <dbReference type="ChEBI" id="CHEBI:17836"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="EC" id="2.5.1.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 22">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 22">In the C-terminal section; belongs to the DHPS family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 22">In the N-terminal section; belongs to the DHNA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20 22">In the central section; belongs to the HPPK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875653.1">
        <property type="nucleotide sequence ID" value="XM_007877462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLQ1"/>
    <dbReference type="STRING" id="1069680.M7NLQ1"/>
    <dbReference type="GeneID" id="19897247"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03560"/>
    <dbReference type="eggNOG" id="KOG2544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008023_2_0_1"/>
    <dbReference type="OMA" id="ESEPMYF"/>
    <dbReference type="OrthoDB" id="615426at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00534">
        <property type="entry name" value="DHNA_DHNTPE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.20:FF:000006">
        <property type="entry name" value="Dihydropteroate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="entry name" value="7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="entry name" value="Dihydropteroate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016261">
        <property type="entry name" value="Folic_acid_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00526">
        <property type="entry name" value="folB_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="FOLATE SYNTHESIS PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941:SF1">
        <property type="entry name" value="FOLIC ACID SYNTHESIS PROTEIN FOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000741">
        <property type="entry name" value="Folic_acid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="Dihydropteroate synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16 22" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="13 22" id="KW-0418">Kinase</keyword>
    <keyword evidence="17 22" id="KW-0456">Lyase</keyword>
    <keyword evidence="15 22" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 22" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="23">
        <location>
            <begin position="473"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00009640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00009951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00058009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00061548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00067568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRNR" id="PIRNR000741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EMR08122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="742" mass="83761" checksum="F7138C50A49776F5" modified="2013-05-29" version="1">MIFKTKSLKISPFYQIYGFRFVKGMIFKKKIHLSKLNKDQDLIHIHSLALKSIVGKNSWAQRLLQPVVLTLSMGINASLSGSMDNLSYSIDYATVYKEVFKLVENSKFENLVDLSDKISKVVLGDKCKGNWVKVIVETPKGHLLAETGLQIIRRKDGIRKVEDQFFIRNLSLYTIIGINPEERVNKQNIIIDLILFKSFVNLECKDDLIINTYNIEKLLKEVVKHVEESTFKTIEALALSIARISCMSHNIEKIAVKVEKSCALAFAKSAGVEIVRSRSCFSSDNCIKSGKSIDNEAIYISLGSNLGNRVKFILDAIEKMSTKGIKVLKTSMLYESKPMYFKDQPAFYNAVCKVQTSLHPEQLLFELQLIEKELGRVKVIDKGPRCIDLDIVFYGRKIINSESLIVPHPRVLERSFVLKPLLDISSDLVHPVTGLSIASYFEKIVDHSIKPVLPFLYKNKSMNFSFRSYKVPTYIMAILNLTPDSFFDGGIHSCDSVLIDVKKFINAGATIVDIGGQSTRPGSHIIPLEEEIFRVIPAIKYLLKTYPDILISIDTFRSEVAEQAVKAGASLVNDISGGRYDPKMLSTVARLKVPICIMHMRGNFLTMDNLTDYGVDIIEQITIELEELLNSAEKSGIPRWNIILDPGLGFSKTFHQNIELLRRFNELKSKNCFNGLPWLLGPSRKRFTGFITGDNMPKDRIWGTATAVAASISGGCDIIRVHDVHEMYKISKMSDAIWKEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLX1</accession>
    <name>M7NLX1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_03368</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875451.1">
        <property type="nucleotide sequence ID" value="XM_007877260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLX1"/>
    <dbReference type="STRING" id="1069680.M7NLX1"/>
    <dbReference type="GeneID" id="19897055"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03368"/>
    <dbReference type="eggNOG" id="KOG2063">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008225_0_0_1"/>
    <dbReference type="OMA" id="DNWKGNF"/>
    <dbReference type="OrthoDB" id="5325112at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF27">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="27"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="968" mass="113159" checksum="089F938AAE0599A6" modified="2013-05-29" version="1">MQFVQHNIRSLFFDKIEFRESGNEEKRLNVTVIETDGINLYIGTSNGYVYHFVLENRKSLSLFPEFIFASKHNLLEKKLVKLILVLSQITCVVILCGNVLFFCNYPELSPVFGLEPIKGVVDICQDLDKYGETELDGSVILTVLMKRKIKRIKVKDTISVVLDIDYSSVVSICQRGFICCVATISSYELINFENNRRIPLFPIIQGNDPLHHNFLRISTPFLRPIIISISKSEFVVTSLFDGKNSVGLFVDINGNIVRGTIMFSEYPISLASEFPFLMALMDNSFVEIHNIIDQTLVQVVQSPLLGSITNIFRTFGHYCIFSESLMKKIVMVKAMSSKDPETRDDDIKNNKFLEEMNIATRLSSIPSKVFLTGENGISCLVFDSILVHVDELLNLKEIDNALLFIKKFTKIITPENIHSERIYHEISYIRQKSGFVYLEKILFDDAIIQFEESDIDPRLVISLFPVFDVKLDGVMTYKGVDEIICRLVDIDNIISSEISGKFDSYVQLSDEEIETTQNYRKILYQNALNTLKKYLLKYRQRKGLGSIGTGYKNKQIFQVVDLALLKLLVYLSPEEDSNVLYKLVDSGVECFDDAVIIFEENEKYFLLSKLYQNMKMQNKVLEIWKNILDGNLSDHEFLDGEKKMKDYLFEVDDDNLRIDYAIWLLERMQHIGIEFFINISSKKPFKFSIDEMVNIFRSRSKICLKIYLEYLVSNFSNLSFLNELLLLYLDEIINYLQIPLIRDATKKSIKDYSELNDDKLPYFEYLSTCMIENDERYQKFVSNRIKLIEYLQSVSDYDFELVLKHLYSQKDLLLIELVILYGRFSRHEEALTILVQILKDYKTSEIYCYHRGLFVKSYYDNKDSNEFLSQRKKLFKMLLDQYLKLPDYDQRLSRISFLLRHWNIYLDAIYVLNTISNDWSIEKISDFLITILQKNIQEKHHSFLIKSLHRGFSTLYDYSKFISFTNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLX4</accession>
    <name>M7NLX4_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S ribosomal protein S17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_03579</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875672.1">
        <property type="nucleotide sequence ID" value="XM_007877481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLX4"/>
    <dbReference type="STRING" id="1069680.M7NLX4"/>
    <dbReference type="GeneID" id="19897266"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03579"/>
    <dbReference type="eggNOG" id="KOG0187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112958_0_1_1"/>
    <dbReference type="OMA" id="HTEHIEV"/>
    <dbReference type="OrthoDB" id="1727351at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.60.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="entry name" value="Ribosomal protein S17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00511">
        <property type="entry name" value="Ribosomal_eS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_eS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018273">
        <property type="entry name" value="Ribosomal_eS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="Ribosomal_eS17_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002242">
        <property type="entry name" value="PRK01151.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="Rps17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00712">
        <property type="entry name" value="RIBOSOMAL_S17E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="139" mass="15870" checksum="CBE6092A9320A96F" modified="2013-05-29" version="1">MGRVRTKTVKRASRVIIEKYYPRLTRDFHTNKKVCDEVAIIASKKLRNKIAGYTTHLMKRIQKGPVCGISFKLQEEERERKDQYVPEISALSTNVTALEVDIDTKNMLKAIGYDSVAVTVNTSLAGAVEQQTFRNQRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLZ1</accession>
    <name>M7NLZ1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">General transcription and DNA repair factor IIH subunit TFB5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01875</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the 7-subunit TFIIH core complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TFB5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873849.1">
        <property type="nucleotide sequence ID" value="XM_007875658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLZ1"/>
    <dbReference type="STRING" id="1069680.M7NLZ1"/>
    <dbReference type="GeneID" id="19895569"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01875"/>
    <dbReference type="eggNOG" id="KOG3451">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166246_3_2_1"/>
    <dbReference type="OMA" id="IYNPMDE"/>
    <dbReference type="OrthoDB" id="354at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006294">
        <property type="term" value="P:nucleotide-excision repair, preincision complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1220">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035935">
        <property type="entry name" value="TFB5-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009400">
        <property type="entry name" value="TFIIH_TTDA/Tfb5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06331">
        <property type="entry name" value="Tfb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01395">
        <property type="entry name" value="Tbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142897">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="69" mass="7969" checksum="43846EDE1EF04AE6" modified="2013-05-29" version="1">MPRATKGVLIECDPTVKQIILNLDNQTHDIVLEDLDERLLVHSQQLDRIRLELDRVLEENSFNSLPAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NM55</accession>
    <name>M7NM55_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b-c1 complex subunit 2, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Core protein II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_01933</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873909.1">
        <property type="nucleotide sequence ID" value="XM_007875718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NM55"/>
    <dbReference type="STRING" id="1069680.M7NM55"/>
    <dbReference type="GeneID" id="19895627"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01933"/>
    <dbReference type="eggNOG" id="KOG2583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_0_1_1"/>
    <dbReference type="OMA" id="PTHNESR"/>
    <dbReference type="OrthoDB" id="6369905at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000021">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000039">
        <property type="entry name" value="Ubiquinol-cytochrome c reductase core subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF209">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="12">
        <location>
            <begin position="50"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="13">
        <location>
            <begin position="193"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR09748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="443" mass="50132" checksum="EDDB6BBA2736FB02" modified="2013-05-29" version="1">MPFFRKKMALTKRICLFYRTFKKTASKSSDFSRFSLTQTNGINVISKDTGGYGTSLSVVIRSGSRFEPVFGLSHLLERFAFKNTKCRSSLRIIRETELLGGDIFSRRSREILTLSAQFLRDDLAYFVELLAEVLIKTKYNEFELNETVLPYALSENKRCYNEPAVFGQDVLHEIAFRRGLGRSIYTNERNYATVEMIGDYAKKSYVKNNLVVLATNADQSKLEELISEHFNDLSVGTLASSPKTIYYGGENRIGFKSYMNHFLISFPRPAAFMPSSEEYILLSYLLGTGSRVKWSYENSPFGIIEKNLSNGTKLLSNNFVYSDAGLFCIHIYGPIETLQVAVKSSIEALRSLAEKIDNNDIKRAISQAKYSLFDVDTDPIKIHEELGSYYLSSGSLLDQESIASRIEKITATEIKSTISKMFETKPSVVVVGDTNVLPYYDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMM8</accession>
    <name>M7NMM8_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_03221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875284.1">
        <property type="nucleotide sequence ID" value="XM_007877093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMM8"/>
    <dbReference type="GeneID" id="19896908"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03221"/>
    <dbReference type="HOGENOM" id="CLU_1310585_0_0_1"/>
    <dbReference type="OrthoDB" id="5388821at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="210" mass="24551" checksum="B222B63B8802F3A9" modified="2013-05-29" version="1">MNFLKKQTVLFLDEFERSELFPTNIALSSERVFYNVEDGVNSEEKQSYLNVLTKSHKKFRRKRKKVLSFFKDEKEVWSSQELTKLRILQKFIKTVDSERFSQLSKLLLNNKSTEEVNKRLSDDKMSNCLNKPVSALQKLIEYENMLDSQDVCEKKDNIDRVLGLVNHFEPGNTLKTSEMDIVLGLTKNNIENKKNIMDCVLGLNKTKTMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMT6</accession>
    <name>M7NMT6_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_03273</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875344.1">
        <property type="nucleotide sequence ID" value="XM_007877153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMT6"/>
    <dbReference type="STRING" id="1069680.M7NMT6"/>
    <dbReference type="GeneID" id="19896960"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03273"/>
    <dbReference type="HOGENOM" id="CLU_2039021_0_0_1"/>
    <dbReference type="OMA" id="WTIPMRI"/>
    <dbReference type="OrthoDB" id="19981at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021013">
        <property type="entry name" value="ATPase_Vma12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11712">
        <property type="entry name" value="Vma12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="121" mass="14256" checksum="BD12E60166C8DFF1" modified="2013-05-29" version="1">MHSIAEEMNYQRLIGIQDPYYKNKELSKNELRLIKNQIFTIINILVSIFSIIVAIWIWCKNWTIPMRIITALSSGIVIAIAEIVLYNHYLSSIKKRQEFERNKPLKKEIINTIKFEGCKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNA5</accession>
    <name>M7NNA5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01447</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873387.1">
        <property type="nucleotide sequence ID" value="XM_007875196.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNA5"/>
    <dbReference type="STRING" id="1069680.M7NNA5"/>
    <dbReference type="GeneID" id="19895144"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01447"/>
    <dbReference type="eggNOG" id="KOG3424">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107248_1_0_1"/>
    <dbReference type="OMA" id="IRVKKYM"/>
    <dbReference type="OrthoDB" id="5571754at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3370:FF:000001">
        <property type="entry name" value="40S ribosomal protein S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018098">
        <property type="entry name" value="Ribosomal_eS24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00529">
        <property type="entry name" value="RIBOSOMAL_S24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="133" mass="15635" checksum="A7999F16D43A73D8" modified="2013-05-29" version="1">MSDSITIRTRKFLTNRLLCRKQMVVDVLHPNRPNVSKNDLRERLAYMYKTDKNTVQVFGLRTQFGGGKSTGFALIYDSFELMKRFEPKYRLVRIGLEEKVDRTSRQQRKQRKNRSKKFRGVAKKAAMTASTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNB9</accession>
    <name>M7NNB9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01461</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873400.1">
        <property type="nucleotide sequence ID" value="XM_007875209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNB9"/>
    <dbReference type="STRING" id="1069680.M7NNB9"/>
    <dbReference type="GeneID" id="19895157"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01461"/>
    <dbReference type="eggNOG" id="KOG0235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_9_2_1"/>
    <dbReference type="OMA" id="DANNERW"/>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045820">
        <property type="term" value="P:negative regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043456">
        <property type="term" value="P:regulation of pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051695">
        <property type="entry name" value="Phosphoglycerate_Mutase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517:SF1">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="23360" checksum="336C4F953EA3C903" modified="2013-05-29" version="1">MRVILIRHGETDFNKNHRLQGSLDIPLNEKGKEQSLKLLKRLSTLEIDKIFCSNLIRARDTIEPFLKSKGNITCEYYEELQENCLGKLNGLTWEEINLKLKEENKTLDDYGENKKKFISRIMKFWKKKIIPIRNEISTLIVITHGGYIVTLVSHLVKLGFLDIPEGIKINGPPKNCSMSVIDIRDELLYDLLSYSDDIHLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNI3</accession>
    <name>M7NNI3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA polymerase epsilon catalytic subunit</fullName>
            <ecNumber evidence="17">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PNEG_02967</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">DNA polymerase II participates in chromosomal DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="17"/>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875013.1">
        <property type="nucleotide sequence ID" value="XM_007876822.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NNI3"/>
    <dbReference type="GeneID" id="19896654"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02967"/>
    <dbReference type="eggNOG" id="KOG1798">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MLDQCRY"/>
    <dbReference type="OrthoDB" id="10060449at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140529">
        <property type="term" value="P:CMG complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903460">
        <property type="term" value="P:mitotic DNA replication leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05779">
        <property type="entry name" value="DNA_polB_epsilon_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05535">
        <property type="entry name" value="POLBc_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000002">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000005">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000010">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1600.10:FF:000006">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013697">
        <property type="entry name" value="DNA_pol_e_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029703">
        <property type="entry name" value="POL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055191">
        <property type="entry name" value="POL2_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054475">
        <property type="entry name" value="Znf-DPOE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08490">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22634">
        <property type="entry name" value="POL2_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22912">
        <property type="entry name" value="zf-DPOE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23250">
        <property type="entry name" value="zf_DPOE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01159">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 17" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 17" id="KW-0235">DNA replication</keyword>
    <keyword evidence="14 17" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="12 17" id="KW-0408">Iron</keyword>
    <keyword evidence="13 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 17" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase epsilon catalytic subunit A C-terminal" evidence="19">
        <location>
            <begin position="1488"/>
            <end position="1876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU365029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMR08797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="2177" mass="253491" checksum="8C667EE374C4D260" modified="2013-05-29" version="1">MGRQATRKKPHLYQKRLPNDRKPSSSGYERWERLQLVNIIDERMGFERLEIGPPMEGWLINMHETALLDDTQGGKAAMAFYFLQDDGEAFKVILPFEPYFFIACKTGSEIEVEAYLRKMFNTIVRITRCMKEDLQMPNHLSGYRRLFLQLFFNNTMDLMSVQKVLVPLAEANKKKMDLLDSLNEVVTATADTTLYQEIYHSSCSIRSEDYIIDAREYDVPYSVRVAIDKDIRVGKWYQVNPQVGTVSIEVIEDRIARAEPVVLVFDIETTKLPLKFPDSAIDQIMTISYMIDGQGFLITNRDIVSLDIDNFEYTPKPEYEGPFCIFNEPDEKSLIQRFFNHIKDAKPTIIATYNGDFFDWPFIEARSAIYGLNMYDEIGFSKNKNDEYQSSYCVHMDCFRWVKRDSYLPQGSQGLKAVTKAKLGYNPIELDPELMTRYAIEKPQVLAQYSVSDAVSTYYLYMKYVHPFIFSLCNIIPLNPGDVLSKGTGTLCEMLLMVQAFKKNIILPNKHIDSYDKHFEGHLLESETYVGGHVESLEAGVFRNDIQEKFNVDSNTIEKLINELDPALKFTIEVEAKKKVSDILNYDKIKQQIILQLDDFKKSPFRTEYPKIYHLDVASMYPNIMITNRLQPDSMIDESRCATCDFNKPGKTCDRKMTWSWHGDFFPAKRDEYNMIKHALRNETFPTKVHGTLKSFDELSASEQSSIIQKRLTEYCKRIYGKIHDSKVVERETIVCQRENPFYVDTVKSFRDRRYEFKDLQKQWKLRLDNIPSSNPSQIDEARKMVVLYDSLQLAHKVILNSFYGYVMRKGSRWYSIEMAGVTCLTGARIIQTARQLIEKVGRPLELDTDGIWCILPSTFPQNYIFNFVDGKTLFISYPCVILNYLIHSQFTNHQYHNLVDPLRYKYEIHSENSIFFEIDGPYRAMILPASTEEDKTIKKKYAVFNNDETFAELKGFEVKRRGELKLIKIFQSQVFKLFLEGTTLEECYAAVATVANKWLDILYTKGVTLADEELIELISENRSMSRTLEEYGSQKSTSIFTARRLAEFLGDQIIKDRGLACKFIISSRPKDASIVERAIPVAIFSVDENVKKHFLRKWLRDNNLSDYDIRTILDWDYYLKRLSSVIQKLITIPAAMQMVPNPVPRVAHPEWLQKRHSARFSGLKQHSITESFKALPKIMEDITNTNKRSFADIEESPFQKPTKTIFKTSNSIEGINENEREDDFSTLGPLTVTIDQDYKLWLQYQKRKWKIQKQSRDRRRYLFGPNIDINNSLSSFFHNKAIYTYTKTWEILEFRQTDIPGELRVWVLINNILHSIKLIIPRIIYINFKSANFPEFELEGCEVEKVSKVLPNGKQFPYLFELKMSEHIYNNEQKLFLNFFNHPSIDGVFETQITTKERAILLLGAVCEFKNTTQGSLKKALEKGFDLEMLEKSNKNISYLDKSKLSFIFVSLFFAGNRKILSIFYSNKHIANLFVMDNSRETPVFPNFEKLYTELLSNWKSQDLFNDSAFEFSDSITFKILILKNEKKLYKSFSTCLREYQTERHGPTIVVHTLKYDQLSQSFPILLDFPLMKFPQDDNNVPSLGWQTYLGKSLITSFLHLSVFILYRIKLSRYSNIPLCEMSEDDPKFVIDVTFARCLIKNNYLLWWSKSSVPDYGGYEKDWMPYIQEGLDIPLVNNPGSYENVCIELDVKSLTISAILNFALVNAFDSVSEQAFDEFSILDNGIHNDFENFVDSNSSSSVMVVLKSLVKHWWSEASMGNTNADLMVQHFIRWVSSSDSFLYDISLHIYVQKILKKAFLNLLSDLKKAGSKIVFANTFRILIQTSKKSLENAYAYGLYIIKTIRGKPLFHFLDINIKEYWDYLLWMDDANYGGMACSEIKKEQNMDTILHWHIANFLPKILQDEFKAWVTEFISFMYKSKLSALKEFPTQHQFQDHISKSQMPETLSENTILDEIAKPLIKRTSQLFHLQINSFKNDELNLEFQVPILPGSYLEISNPILLFIKCICAVFELVKDFSLDVRMLRRDLLKILDISEFSAESIFQNPSRSYVLPVICQSCGFSRDMDFCRDNDFLIDQSDKKVPILRCTQCLTEYNKLAIEEVLIGKVQHMIKIYQTQDLRCKRCKKMKETNIQEYCACSGNWTSTFDHCQDIFNIFNNIAISCEFKMLEEILQLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNN7</accession>
    <name>M7NNN7_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_02911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874951.1">
        <property type="nucleotide sequence ID" value="XM_007876760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNN7"/>
    <dbReference type="STRING" id="1069680.M7NNN7"/>
    <dbReference type="GeneID" id="19896598"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02911"/>
    <dbReference type="eggNOG" id="ENOG502SBKV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1555911_0_0_1"/>
    <dbReference type="OrthoDB" id="6222486at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09271">
        <property type="entry name" value="RNase_H2-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013924">
        <property type="entry name" value="RNase_H2_suC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47204">
        <property type="entry name" value="OS02G0168900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47204:SF1">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08615">
        <property type="entry name" value="RNase_H2_suC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="172" mass="19673" checksum="1558CCBFC94F8FC9" modified="2013-05-29" version="1">MNQEIVRIILDKNTSKSSHQSTPSYQTSFDCKVHLLPCQIQWDGPANVSKYFHVRSTPDNSTYYATFRGRGLEGNSFILPSTYEGAIYNTDSPISQMFEQLNDNCSTNNIDLNETIVPTKKWHQIGTFSAFNIWKQIPHYDTEFGTSIRTLKEWINLADIIHSVTEIEDDTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNR7</accession>
    <name>M7NNR7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01584</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873538.1">
        <property type="nucleotide sequence ID" value="XM_007875347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNR7"/>
    <dbReference type="STRING" id="1069680.M7NNR7"/>
    <dbReference type="GeneID" id="19895279"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01584"/>
    <dbReference type="eggNOG" id="KOG3445">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117700_1_1_1"/>
    <dbReference type="OMA" id="ISKWIDL"/>
    <dbReference type="OrthoDB" id="88at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000173">
        <property type="entry name" value="Mitochondrial 54S ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039927">
        <property type="entry name" value="Ribosomal_mL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="7">
        <location>
            <begin position="32"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="136" mass="15626" checksum="958637A9BCDFB510" modified="2013-05-29" version="1">MPIQVVQQISKGRNGFGAYIFQCKKIQFCYCNWAGSSRGMNIFLEKMLLKFSKDNPYIEMIVSRRPGKHPVIRGIYVNGREKVICVRNLDPQQILKKAELLKNSSGAKLKKVKWPVSSINKSVRGIWSPFHQQNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP22</accession>
    <name>M7NP22_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_01172</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873087.1">
        <property type="nucleotide sequence ID" value="XM_007874896.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NP22"/>
    <dbReference type="GeneID" id="19894869"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01172"/>
    <dbReference type="eggNOG" id="KOG0920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_1_1_1"/>
    <dbReference type="OMA" id="MCKLVCR"/>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000002">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF145">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX57-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="541"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="819"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="496"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR10458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1355" mass="155916" checksum="E77272D0049C7F79" modified="2013-05-29" version="1">MLNNTNIKERGRKYQENRKRKAKEELVEKDIKKQKTDQEIKKKSKKELKEENKKKKDMNRVFSIAKRNINNLNSYNLVRWMQFNDKSQIIQKKIKQPYNDNKNEKSFIKKNKGIKNYNLNHEYLKNTKYEIKKYWGSDPILYNKTYIEKNMLFPCTEELNKNGISENIFSNPEIFLYKIIGMKPKLTIKSDKFHTRFPYYAFCTGKIDRKIFIGRGHGKTVAEARNNACLFFISKIYEKKLLFNMIEENQIGNYDNDLVSKEANAKLDILNYACRWLALPKFEVSISYTKIKKKKIYTVTAYTEEPKLAGTGRSYDHRIAEILACVNFKKIAEEHHLENDQDHLLIKNWENLNTSNAKKFIQFFEYKIKRGKTETIFKTKNNFWIASIKAGERILAVSPEMYTKKDSEEACFLVYALNIRKEMPHLFVEYIEELKKGNGEFLRPLSLIPTNISDKSLKIMKETISQLKNIQTSENFEEIYSEKEKDLNWLPFKPSLEFLKQRSETLLKQLKALKKGKNQLLNDLFEKKQKLPIFSYKNNLLTLIKENPVCIIIGATGSGKTTQLPQFIFEDAILNNIGAECNILCTQPRKIAAISVAQRVCFERNEKLQESIGYQVRFDNKLAKPVGSINYCTTGILLRQLQDLSSSILERVSHIIVDEVHERSIQTDFLLFVLKKIMKKRKSSGLTPIKIILMSATVDPTLFCKYFGEEFPDKQAPSIFIPGFSFPVSSYFLEDIYQNLKNTFSKKQAPALFDKDTTLYLKSENIFNSNSCKEKEMEITENESNNHSSPIDWSLKNPSNQEELSFMNEKDISDGLIATTISYIIKTSDDGSILVFLPGYSEINSLNKVLLSGRAGLDFSDKFKYRIYMLHSAIPHMQQEVFKKLEPGIRKIILATNIAETSITIPDVVYVVDTCKHREKIYDQTKRITSLLSTWISHSNSKQRAGRAGRVKDGHYYALISKNRYAALAPASLPEILRSDLQEICLQIKAIGMKDSVSKVLSETIEAPSKKAVENGLQRLYSLGALDENENLTPLGTILATLPVEPSLGKMCLMGAIFKCLDPVLILAASASLRNIFVQPIDLQEECRKARTKLSMDYKSDHITIINCFKKWRSIQKNEGNISASDFIEKNFLHRNTLQTIDNVAKQILQILVDHKIISHKEVSEELGGEELNKYSDCIPLIKSLICAGFYPNIAVITNKRLLRTCNDNTVLIHPSSINFPKSSNKNLYGPPISEDITPPGTLYAFGSKSKTDSLKSLILRDTTLLNPLSVLLFGGKLTRHNNIIRIDNWIPFHVKNTQNYIIYEFNEYMDKILTQIFNKLHIQSHHSQTHDILNENKSRNIIVKGVVDALYANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPL7</accession>
    <name>M7NPL7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02818</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874852.1">
        <property type="nucleotide sequence ID" value="XM_007876661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPL7"/>
    <dbReference type="STRING" id="1069680.M7NPL7"/>
    <dbReference type="GeneID" id="19896507"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02818"/>
    <dbReference type="eggNOG" id="KOG3369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053380_2_2_1"/>
    <dbReference type="OMA" id="MPIRTEG"/>
    <dbReference type="OrthoDB" id="246406at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14856">
        <property type="entry name" value="TRAPPC4_synbindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.70:FF:000007">
        <property type="entry name" value="Putative sybindin-like family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF15">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="134" mass="15174" checksum="6B6B7538B76E863E" modified="2013-05-29" version="1">MIFSLYIINKAGGLIYQKDFNEGLLRLGSNDYLLLAGIFHGIHAITAKVSPLAGLGGLELLEAQTFHLQCFQTLTGIKFLLITEPQQPNVDALMRRIYELYADYVMKNPFYKMEMPIRCELFDINVTAVLESIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPP2</accession>
    <name>M7NPP2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02558</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874571.1">
        <property type="nucleotide sequence ID" value="XM_007876380.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NPP2"/>
    <dbReference type="GeneID" id="19896250"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02558"/>
    <dbReference type="eggNOG" id="KOG0168">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0170">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000366_1_1_1"/>
    <dbReference type="OMA" id="AEPLSQF"/>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057948">
        <property type="entry name" value="TPR_TRIP12_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25579">
        <property type="entry name" value="TPR_TRIP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="1298"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1006"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1653" mass="188154" checksum="57B5C40517E87544" modified="2013-05-29" version="1">MEKEKGSYESLRENVSSELGGGSSKKGNIKKKRGSFDELSAYIDDSYTERSIHENSSKHTTSGNTPVSYLGVLDSKSSSGDISLFSETNDHNEQHKSSTVENIYNEEYDEIDENFEDRYYNENERHYSHDYDEETSDLFDHGNFQDSLHSALTGVFSGIASRFKIILSSLRQKEDPSAQLIALQGLSELLIVSTEDTLSGYFSPDLFVKELVSIMKTGGSGFCSENPEMMLLACRCLANLMEALPSSISNVVYGGAIPVLCQKLLEIQYIDLAEQALSTLEKISTEYPTAIVRDGGLTACLTYFDFFSTNVQRTAIVTAANCCRNVPFECFATARDVMSMLQNIIGNNDRKVMEQACLCVTRIVESFRHHPDKLEQLLSNDILQIIMSVLSNASTNAVSLYTHTQFLRVLGIAAKASPNLSVAILKLKVVETIYYILIGRFPVDDVNCTKGDITDTLYTLIHRPREHIYEILNLMSELLPNFPRDDEVFNPCISENSRLQISSKSTKYKMLDEQRFRLLEDCQEEMKHFSKIIMPILVDIYHSAINVNVRRRVMIILLKIVVNLKENVLYESVKHSQFSFFLATVLSQHEYPSLVLGALQLSELLLRRLSSVYLQIFAREGIIQSVHEISNFSLEEINLKNFNSNKAFSFCTSSVSNKMPASDFLLILVKRAKSFISIYEKCENKSLVCEGASNIMFKLTFLAKRIKNHIKIRSTYRKLSRYFVSNDSTITSYEILSSGLLVSLLDSLTDPNVEVRQSSRKAFLRSFLINAFDTAVVLGGNSFNSPFSILIQKLHESLSRNEDLEVITVHGGSHEDFYRNPSAMLAKQLKLKLIAEEGSNVPRAYKTFIVSIYSVATFRTLDQYLRPRLTSSQRISISRSNNSKTSSTSAASAIISSNVSNQSSLNKDKRMHRIKDQSFVIEKRKRSTRANVPEQIKSDLQIHKIKNSKTGIYDDEMLEYTNDLSGSDSIDMSHQLFEIIDVTESNEKSVGVDNDIQIDTESSKISKTDTKMKGKEHIETSLEKNESKPSTSTDKKYMSYSSALQTKEDWCIRFEMNDEAIDPDSTIYSAIHRYNIQNGRESSDIWSFIYPVKFRKVPKPGDYENSREETIKTTDIRFETHDFSSYNANTVLILKLLRVLYLLNINIRNILDFNTFSNVVNMTLPLSSFVNPKLTAKINRQLEEPLVVTSLCFPLWVQEFPRLFLFLFPFETRYLFLQSTSFGYLRSITRWQNINGRDESYHNLRDDSRLLLGRLQRQKIRISRDHILESTIKIMDLYGSSPFLLEIEYFDEVGTGLGPTLEFYSTASHEFMKKNHGLWRNVDDLSEDEFVFSPNGLFPAPLGTSSTDLDDKWKRCSLFKVLGKLIARSMLDSRIVDILINPMFFRIASGTNEVKLSIESISEIDKDLANSLYFLMQFDIAKKKILNKNICEKEQELRLNDIRIQDVSVEDLSLNFTLPGFPNIYLVSNGHEKSVTIHNIGEYIDLIIDFTIGKGVKEQINAFRDGFSSVLPYSSLALFTPEELSILFGQGKEDWSIETLLDSIKADHGYNMDSRSIRNFLDILTNMNDMERRQFLQFITGSPKLPIGGFKNLTPPLTVVCKSHEPPLTPNDYLPSVMVCVNYLKLPDYTTKKIMKTKLFLAMKEGQGSFHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPV0</accession>
    <name>M7NPV0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">mitochondrial processing peptidase</fullName>
            <ecNumber evidence="5">3.4.24.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Beta-MPP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PNEG_00882</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. Preferentially, cleaves after an arginine at position P2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.</text>
            <dbReference type="EC" id="3.4.24.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.64" evidence="5"/>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872793.1">
        <property type="nucleotide sequence ID" value="XM_007874602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPV0"/>
    <dbReference type="STRING" id="1069680.M7NPV0"/>
    <dbReference type="MEROPS" id="M16.980"/>
    <dbReference type="GeneID" id="19894580"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00882"/>
    <dbReference type="eggNOG" id="KOG0960">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_4_0_1"/>
    <dbReference type="OMA" id="IDVVCDM"/>
    <dbReference type="OrthoDB" id="10251424at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017087">
        <property type="term" value="C:mitochondrial processing peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000002">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF149">
        <property type="entry name" value="GH01077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="15">
        <location>
            <begin position="55"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="16">
        <location>
            <begin position="208"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMR10733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="394" mass="43860" checksum="0C110FAC8420EDCA" modified="2013-05-29" version="1">MKPQVILTKSALRGLIHEKHSLKRIFYNTSIKNYASVSGFIQKTKTTTLSNGFTVATESFPHSKTATVGVWIDSGSRSESTENNGVAHFLEHLAFKGTKSRTQQDLELEIENMGAHLNAYTSREQTVYYAKSFQDDVPKVVDILADILQNSKFEASSIDRERDVILREQEEVDKQIEEVVFDHLHATAYQGHPLGCTILGPKENILSIKHEHLISYINENYTADRMVLVGAGGVSHEQLVELAEKYFSNLPASPNPLDFGSSRGAAPKFTGSEVRIRDDTSPTANIAIAVEGVSWKHPDYWVMLVMQAIVGNWDRTLGSASHLSSKLSGIVSKYNLANNFMSFSTSYSDTGLWGIYLVSENLTGLDDLVHFTLKESFVCDNKYVIFNVNRNGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ11</accession>
    <name>M7NQ11_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00926</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872838.1">
        <property type="nucleotide sequence ID" value="XM_007874647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ11"/>
    <dbReference type="STRING" id="1069680.M7NQ11"/>
    <dbReference type="GeneID" id="19894624"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00926"/>
    <dbReference type="eggNOG" id="KOG3103">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074741_3_1_1"/>
    <dbReference type="OMA" id="HIRAKSM"/>
    <dbReference type="OrthoDB" id="440385at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="89"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="245" mass="27156" checksum="46E20245534AB0E9" modified="2013-05-29" version="1">MSKNFFSSNQTEDLKFYPSNYGHLGKETFLVDKRDANMQSCMQDTSFGVWENKMGWIAAFGTGGYPNEPPLLEELGVNFLHIKGKTLAVLNPLKSVDDHIMDDSDLAGPILFCLLFATFLLLSGKRHFGYIYGVALLGCISLHTIFSLMSFRGLHFSRTVSVLGYCLLPLVLTSACGVLVSMDGLVGYIVSSVAILWCTYSASAMFVVAFQLNEMRFLVAYPVALFYSVFAVMTVFAEKNVYVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ14</accession>
    <name>M7NQ14_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00931</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872843.1">
        <property type="nucleotide sequence ID" value="XM_007874652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ14"/>
    <dbReference type="STRING" id="1069680.M7NQ14"/>
    <dbReference type="GeneID" id="19894629"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00931"/>
    <dbReference type="eggNOG" id="KOG3297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073901_1_1_1"/>
    <dbReference type="OMA" id="LGPTLWW"/>
    <dbReference type="OrthoDB" id="10256606at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04330">
        <property type="entry name" value="RNAP_III_Rpc25_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000221">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013238">
        <property type="entry name" value="RNA_pol_III_Rbc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08292">
        <property type="entry name" value="RNA_pol_Rbc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="7">
        <location>
            <begin position="9"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III subunit Rpc25" evidence="8">
        <location>
            <begin position="84"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="192" mass="21864" checksum="3EA014AAFEF2697D" modified="2013-05-29" version="1">MAFILTVLSDTICLAPCTFRKQTMIALKDEINLKFANKVVIHTGLCICLYDILYCGKALIKYGDGCAYIPVKFRLVVFRPFIGEVLTGKIQSSSHSGIKVSLGFFDDIFIPKSLLWEDCEFDIDEQRWIWHSSHGDLFLNTGETIRFTIESETFVNSNPFMTPNQTCEQEQAPYTLTASCNKDGMGSIFWWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ21</accession>
    <name>M7NQ21_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874555.1">
        <property type="nucleotide sequence ID" value="XM_007876364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ21"/>
    <dbReference type="STRING" id="1069680.M7NQ21"/>
    <dbReference type="GeneID" id="19896234"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02542"/>
    <dbReference type="eggNOG" id="ENOG502SAYM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_455010_0_0_1"/>
    <dbReference type="OrthoDB" id="9994905at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808:SF2">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="178"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="522"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="600" mass="69451" checksum="C008A65C58D30D08" modified="2013-05-29" version="1">MSDIKKDTDIYIFSNESCEVRHYPILSEKSLCSISSISKQSDSGSMDFISEYNSLATQYKLPCYPRNSEEENNESNEQICQQNKPETQKKLIKKLCKYQANHSLFHSSKWIGKIMKSKRSEKYYNTISKSNSKRNIFKKSVQNPVEVNTLNSTENPCNECFEKYCNINSHESYGIFGVPLSSLVQEMGTSHITNFPENLMFSEHKVPLIFKICVTKILEKGLETPGLFRVNGSRSVIRSFIEHFLKNKSKISFETDIENFKINPNIHDYASLIKKLLVELPGGIIGNKLQLQALFPLLEDRASARVLMPPEIRARMLALALSTIEDQNRFYLACSVFALLRAVATCTEQKERILNYPKDLNYMKPEALGLVFAPTLLGRQINSSDISDIINSEKLSNKEQLGPLKVIKKEKEKARKSAKLIETIIDYWEQIIAQLKKLQPSLHISEFNKNTSQNKIEHSENKDFYKKFYDDNKENIDPNMDEHMLNKFSSLDNNTFTTARTNTDETNSNGTLPKSNKNFTDELEYKEKITNLKNQLVITQKEKEEIQIHLEIKTQEAERLFSRCLDWQRKSEAWQKRAETAEKDLEDYKNNRQVKLVAEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQB1</accession>
    <name>M7NQB1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MINDY deubiquitinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874615.1">
        <property type="nucleotide sequence ID" value="XM_007876424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQB1"/>
    <dbReference type="STRING" id="1069680.M7NQB1"/>
    <dbReference type="GeneID" id="19896292"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02600"/>
    <dbReference type="eggNOG" id="KOG2427">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_637963_0_0_1"/>
    <dbReference type="OMA" id="HTRFSNE"/>
    <dbReference type="OrthoDB" id="10261212at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016807">
        <property type="term" value="F:cysteine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007518">
        <property type="entry name" value="MINDY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033979">
        <property type="entry name" value="MINDY_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063">
        <property type="entry name" value="NF-E2 INDUCIBLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04424">
        <property type="entry name" value="MINDY_DUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MINDY deubiquitinase" evidence="2">
        <location>
            <begin position="75"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="430" mass="49788" checksum="2BD787B0D66BF799" modified="2013-05-29" version="1">MTSEITHKTNIKSLYENIGNLETKVLKPEILKKNEQLNKLDQVNDLKIIPDQLYSIKNKKNSSFSCLSDDLSGIYYYTKVINWYDKKTESIVQRTIVCQNENSPYPIIPLANLFILQDSSGNFLSGYSLQNSQISASSLLSIIANYVVSSVSEEHLDNILPRLPLLHKCLNVNPCFKDISRFDGEESKIFSILGVQLFHGWLPSLQEDGFDIYNAIIKAETYENALEKISIMKELLENKNLEYASSDEKISEGRLLNRFLCSYPRCLTPHGITVLREKMSPGNLSILFHNLHFSLLYSHYQTGDLYTLVTDYAYKDYENKVVWESLETSLYFNSDFILQDNLFNDLSGINNDFSLALNMQLMEDQQKENWVYYLSQSKKYKKHKTSGKVKEKKKNSRSNNDVVPSWKRRASDSFEKLNKHLQKEKKCIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQC3</accession>
    <name>M7NQC3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01064</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872975.1">
        <property type="nucleotide sequence ID" value="XM_007874784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQC3"/>
    <dbReference type="STRING" id="1069680.M7NQC3"/>
    <dbReference type="GeneID" id="19894761"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01064"/>
    <dbReference type="eggNOG" id="KOG3177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079653_1_1_1"/>
    <dbReference type="OMA" id="IDGPFKY"/>
    <dbReference type="OrthoDB" id="292693at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07813">
        <property type="entry name" value="COQ10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF10">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="4">
        <location>
            <begin position="50"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR10918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="192" mass="22456" checksum="71C9778297737189" modified="2013-05-29" version="1">MFTWVLHPNHLLFQKKISLTKSFNLFIRNQDFLNSILNKSKRFSTYRILPYKKSLIFSVISDIDSYSAFLPYCLASKVTKRDKNGLPQTADLRIGWKSYDEIFSSKISYISHDYIIANASNHQLFQKLQATWSLKDIQTTEKLEKKTKISLILDFRFSNPLYTIISMAAMPRISSLIITAFENRIKQIEKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQE2</accession>
    <name>M7NQE2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THO complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01083</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872995.1">
        <property type="nucleotide sequence ID" value="XM_007874804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQE2"/>
    <dbReference type="STRING" id="1069680.M7NQE2"/>
    <dbReference type="GeneID" id="19894780"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01083"/>
    <dbReference type="eggNOG" id="KOG2216">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082754_0_0_1"/>
    <dbReference type="OMA" id="HKYMKLP"/>
    <dbReference type="OrthoDB" id="20582at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019163">
        <property type="entry name" value="THO_Thoc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375">
        <property type="entry name" value="FMS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375:SF3">
        <property type="entry name" value="THO COMPLEX SUBUNIT 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09766">
        <property type="entry name" value="FmiP_Thoc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="153"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR10938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="24714" checksum="64DF2AC28E7764CF" modified="2013-05-29" version="1">MENLESLESNNQYLSIDNNQEKVFETCLDLAKKARQQCHQLLQSYPIDSKAKTHLMTLITRLRAANRAAYLEARTSKQETQRSRQSLDQKYVQLQNLYYEQQHILTTIKACETFPTTYDSLSMISEEEFLALHPNLNNATDQHILMLARLSYEKKERENLEKIRRDLLKQKSELISQNKTHKEELEALDSQLKNFIRNAEPLQEFMKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQI1</accession>
    <name>M7NQI1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">Mitochondrial import inner membrane translocase subunit TIM44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_02113</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the Tim44 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874095.1">
        <property type="nucleotide sequence ID" value="XM_007875904.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQI1"/>
    <dbReference type="STRING" id="1069680.M7NQI1"/>
    <dbReference type="GeneID" id="19895807"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02113"/>
    <dbReference type="eggNOG" id="KOG2580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020932_2_0_1"/>
    <dbReference type="OMA" id="NFQMEPF"/>
    <dbReference type="OrthoDB" id="10265990at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.240:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017303">
        <property type="entry name" value="Tim44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039544">
        <property type="entry name" value="Tim44-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037871">
        <property type="entry name" value="TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00978">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 13" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim44-like" evidence="14">
        <location>
            <begin position="269"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR037871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR09527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="430" mass="49534" checksum="E7B3078643C92DEA" modified="2013-05-29" version="1">MNIWPFFILKNPYISSIQVHSFHRSIPSLQDDKGGYKNPFHVFIDTVKSELEKSKEFQESVKALQDKSGRLGESEAYKKAVEAYNVAKKSADVAGNISNQTLKKAGQIIGDSVVAAWESAPIKLARKGTSMTANAISAATDPIRKNKIYKSVTESVKQAIHDGDSSHYAGYIDKKTRRQVRKSKNKENIGSDQKMFKENPNTDLKIIIYKDSAWKESWRRFRNNAWIFNYFDNWQRLFYRSENPVIEMTKAILTSIKNVWYKLFSENEAAKVARLLKNIDPSFRIESFLQELREYILPELVEAYVKGDFQTLKLWLSEASYQIWLITAKEYISQGLISDGKVLDIRGVDVVSYRVLSPNDIPCLVISFRAQEIHLYKNAKTKELVAGNEDFIQEVTYTTAFTKFPDEVLNNETRGWKIIDFIRTKTRDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQL8</accession>
    <name>M7NQL8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcium-binding protein NCS-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02341</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874345.1">
        <property type="nucleotide sequence ID" value="XM_007876154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQL8"/>
    <dbReference type="STRING" id="1069680.M7NQL8"/>
    <dbReference type="GeneID" id="19896034"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02341"/>
    <dbReference type="eggNOG" id="KOG0044">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072366_1_2_1"/>
    <dbReference type="OMA" id="EYVFNVF"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000009">
        <property type="entry name" value="Visinin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF178">
        <property type="entry name" value="NEUROCALCIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="190" mass="22006" checksum="208D907DC2DD9CBB" modified="2013-05-29" version="1">MGKAQSKLSQEQLLELQDLTKFDKKELQQWYKGFLKDCPSGQLCKEEFQGIYKQFFPFGDPSSFAEYVFNVFDSDKNGMIDFKEFICALSITSRGRLEEKLMWAFRLYDINNDGLITRNEMLQIVGAIYKMVGNMVKLPEDEDTPEKRVNKIFGMMDKDCDGYLTLEEFREGSKKDSTIVQALSLYDGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQS9</accession>
    <name>M7NQS9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA polymerase</fullName>
            <ecNumber evidence="12">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PNEG_02201</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="12"/>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874184.1">
        <property type="nucleotide sequence ID" value="XM_007875993.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NQS9"/>
    <dbReference type="GeneID" id="19895894"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02201"/>
    <dbReference type="eggNOG" id="KOG0970">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001718_1_0_1"/>
    <dbReference type="OMA" id="MTKMNVG"/>
    <dbReference type="OrthoDB" id="6755010at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007534">
        <property type="term" value="P:gene conversion at mating-type locus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05776">
        <property type="entry name" value="DNA_polB_alpha_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05532">
        <property type="entry name" value="POLBc_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000003">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000036">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2820:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3200.20">
        <property type="entry name" value="DNA Polymerase alpha, zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024647">
        <property type="entry name" value="DNA_pol_a_cat_su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038256">
        <property type="entry name" value="Pol_alpha_znc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045846">
        <property type="entry name" value="POLBc_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015088">
        <property type="entry name" value="Znf_DNA-dir_DNA_pol_B_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12254">
        <property type="entry name" value="DNA_pol_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08996">
        <property type="entry name" value="zf-DNA_Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase alpha catalytic subunit N-terminal" evidence="17">
        <location>
            <begin position="19"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="15">
        <location>
            <begin position="459"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="14">
        <location>
            <begin position="765"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger DNA-directed DNA polymerase family B alpha" evidence="16">
        <location>
            <begin position="1239"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMR09617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1421" mass="165092" checksum="A16E40879AF06F57" modified="2013-05-29" version="1">MSSQAGQRSNSKKTIHAKLAELRALKAAGKTRLQSYKVIEEDQVYDLVDEEGYRAIVRQRLNEDDFVVDDHGEGYADNGTEEWERSEIEMSSEEEKLYYKKEEKKVKNKKMEHFFKKKPTIPTIKPTTEEDMDFMADILGKMDSEETELILKRKQELASIPRKRLASPPLNNSSIYNRLEKASAIYRKQKISSSPMHPESDDYHLSSHPSSDIMSSNLPSKTYALSSPINSAFEKLKAESEDENDFDFEVKELVQHNFPKNNDTLYEKSKINPITLTNPPITENKPSQMLETVDASSWLNLNNTLNVVNNPENLYYIGKKENFQDFIEEDNSLKIFWLDYTEFNNSLCLFGKTYNKKSKNYVSCFVQIHGIMRNLYFLPRDFKLENQELKQEVSMSDVYEEVSNLLAKFKINEFKSKPATRKYAFELPDVPYQCDYLKVLYPYTEPSLPQDISGNTFSRVFGVNTSLFEQFVLYKRIMGPCWLQIKQPYFEICQNFSWCKLELGVINPEYIFPISESDLNPPPLTLMSIALRKIINDKENKQEIVAASMRIYENISLDDPTPANNLPCQTFTIVRPIQQFFPIGFESLIKSHKGIIKIEKTESSLLNCLLTKIQNADPDIYLGHEWDNVDFSILLSRMKEKKTMNWHRIGRLRRKEWPKISGSSGVFAEKLLVSGRLLCDLANELGRCLIKAQSWTLSELCHLHLGIKRHEFDDKETVLSWTSTAKGMMEYLIHCEVDTYFIAAIAFKIQILPLTKQLTNLSGNNWAKTLSGSRAERNEYILLHEFNREKYICPDKALIKSKIIDIEEEEELSISTSLKKKDKYKGGLVFEPIKGLYDKYILVMDFNSLYPSIIQEYNICFTTVNRHDCEKDDKIPEFPDEQTPQGILPRLIATLVNRRKQIKNLLKDKNASIIQKIQWDIKQQALKLTANSMYGCLGYTKSRFYAKPLAILITYKGREILRNTKELANSLNLQVIYGDTDSIMINTNIETFEEAIKIGNEFKKHVNERYKFLEIDIDNVYQRMLLHAKKKYAALHLIEIEGKMVPRIDVKGLDMKRREYCILAKEASSYVLDQILSGNQTEYVVEKIHDFLRDFANKMRDGKFQPAKFIIYNKLGKNPEEYPNGKSMPHVQVALKKKEKGDIVKVNDIIAYIITGNENDNRHVAERACTPQEVIKSSNIKIDYNYYLANQILPPIERLCGPIEGTDRTRLAECLGLDVRKYQINEINNCEYKFCTYESRLTDEERFKDVKGLILTCNECNEKIDFKGLAKSKEFVNLEGIFCICGKKFPIYTISAQLESQIRNQNDIYYNAWLLCDDPSCANRTRQIGVYGKRCSIKNCQGQMRFEYSDKTLYNQLLYYDSLFDVDKARAIANNFPNPESILVCAEHNRERFEKLRYITKLYLNHNKRRFVNLQSIFSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQV9</accession>
    <name>M7NQV9_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874065.1">
        <property type="nucleotide sequence ID" value="XM_007875874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQV9"/>
    <dbReference type="GeneID" id="19895779"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02085"/>
    <dbReference type="HOGENOM" id="CLU_451358_0_0_1"/>
    <dbReference type="OrthoDB" id="5399009at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="412"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="481"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="619" mass="72691" checksum="A16A38651AA15FAD" modified="2013-05-29" version="1">MAEKEGRKEAKSMSFFNLQKNITTIPQYNSLKVQSGNIKRTISVFEQLSCPKQLPDKQDISKNTRILAQVQNSSLISGNCFSSVSLEKKENIRMKVVEPLKVIEPLNDVNPQLSPRIMKGVAISERRPSSWAFSPSNVGEFNLDQEKTHSRKSLLDPVEKMENTQELFLFNSKSIKEDPFPLEETKNISKDHNKSLYEKFFELESHENTFHMNDSSSILCNSLDSCSLFEANDLKNELISAKERSDMEKVFNEKYLKLIQQNNKLRNRNRHHEEITDTLNKEVQEKGPLISKTEDNKYIEQINSLSHEVEKLASELNNSSVYNEKLLEQINFCKLESQLSTEILKSEIEKSKDIIKSLEEQLKSHDVNQLNFHEHLESVKLYYIEREKILQNKLISAEQAIDAEKIETAKNMEEIRKKLEESDSLKKNVEEELSFALTANNELLKEISYLKNNCEIKDNYENILKDSEGKNNVFSKDSTYIKEISDQLKITQDELQEERKKLEDKTKQCDILFLEFSELEMKYFNLQKKVLIKNEQITKHIFKIREHELTLESLLKEHNSLIKKLNIQQNILCKYTDMIKEKDNLIKHYKEDFEKLHFIYLEEINHIHNNFENRKILTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQW5</accession>
    <name>M7NQW5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear mRNA export factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00710</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the SAC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872610.1">
        <property type="nucleotide sequence ID" value="XM_007874419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQW5"/>
    <dbReference type="STRING" id="1069680.M7NQW5"/>
    <dbReference type="GeneID" id="19894408"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00710"/>
    <dbReference type="eggNOG" id="KOG1860">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_298457_0_0_1"/>
    <dbReference type="OrthoDB" id="264795at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.990:FF:000008">
        <property type="entry name" value="Nuclear mRNA export protein SAC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017173">
        <property type="entry name" value="Sac3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF37">
        <property type="entry name" value="SAC3 FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037320">
        <property type="entry name" value="mRNA_export_factor_Sac3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="7">
        <location>
            <begin position="105"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="691"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR11113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1050" mass="123117" checksum="0D966FF3CC7E60A9" modified="2013-05-29" version="1">METRGRNWAKDTRGSRIANLFSRIKHIKASSNKGRLQNEEINNQQGAEARQKRFERVQSRNRYEKLKPEREREREEATRLGLIDDPNKPKRLNQALTFVGTCQDMCPLFEREQREYQKNLERWEINPLTGRVDKDLAVKAFHRPAAGNEQALPSDVRPPHVLKSTLDYLIDRIVCGEDSLSETHSFVRDRTRSIRQDFTFQNSRGLEAVDCHERIARYHILCLHQLCEVKSFSQQQENEQLQKVLQSLIEFYDDLRCLNIQCPNEPEFRAYYILSRIQDPDITRQAQTLPTDLFFSFPIQHALKLYALVQRNNERIGIHKTPNTEAAQNLFTRFFKLVASKETTYLMACSIEMHFTNIRKGALKAMRRSYLANHSPFPIDVLAEMLGCDSIEETAINCESYGLTVYRNAQGYPVSVHIHKSSKWDETQPPIKQKFCKRLVEAKRGSQSFSDIINGSMGEPYPTYSLFSTLEKPVNETLEFSVPYLDSNTPAFQPSLFNINQETIDRLDSSTLTSKELFDNIRENNINKFKNKKDEGTLDLESKFPRISKDISSNNIKSTDNIFESLNPHNEIKSSFSNKYHFYDSSSNFNKNLCDLKNITDKEQPKRLSKHQFLDILNTFFLEMMDNQIKAVIATIKTEFESLEKRNKILKEFAHEITESLIIEIIFDAVFESIAENIDKKRVLKNIYKIIKKKYNLRASQKKELEQMREKQRQKLLQYYSALKEINTINIKNKNKGEKAYRFLNNETDENMAETLKKTHYHINELWKNEDLTSILVSKLKHESKISFNFWQLLIFSTDYRTPTSLWLREKFHLKPDLTEFVWRLTTDFDLNIEIIMPMSDTIKKNHYKNIGAIVFECSPLDTQNSLLSAKWDIWKHQLHTLIQSIPCENIFKFPLLIIYWTDLELDIEPNLLFDIHLLKKTHTQLTNVNFFKISSIQETYLKTPFQQLLSCISFNSNTHLSSDFKGIKRLKLDDDILYNTKNNITLFKKIPQNLRKKTRRNSFSFNIQNNSESSYLNQINSSHSIIPTIKPISIQKLLHNIETARKLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NR07</accession>
    <name>M7NR07_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PQ loop repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01874</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873848.1">
        <property type="nucleotide sequence ID" value="XM_007875657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NR07"/>
    <dbReference type="STRING" id="1069680.M7NR07"/>
    <dbReference type="GeneID" id="19895568"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01874"/>
    <dbReference type="eggNOG" id="KOG2913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040201_1_0_1"/>
    <dbReference type="OMA" id="YYEKKWS"/>
    <dbReference type="OrthoDB" id="407617at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF37">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="28385" checksum="C2D8A2DC3FC2FC88" modified="2013-05-29" version="1">MFHNPVIAAILGTIGTILWCIQLIPQIVVNYLRHSTQGFQPLMLLLWSIGAVIMGIYNISRNLNIPLQLQPQLFLVLCFITWGQCLYYEKKWSIYKCITIFSSGGCISGFIEAGFVFIARSLIRQNIKWPIISIGIISSIFICIGLFPPYYDIYIHKCVRGISFIFLLIDMGGALFSFLSLLFELKFDILAAISYSFVFFLEMGIIMFDYYFKLSKWNKKRKLNKKAKQEISEKTMDTIDINVEASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7NR86</accession>
    <name>M7NR86_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PNEG_02215</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the U5 snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874198.1">
        <property type="nucleotide sequence ID" value="XM_007876007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NR86"/>
    <dbReference type="STRING" id="1069680.M7NR86"/>
    <dbReference type="GeneID" id="19895908"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02215"/>
    <dbReference type="eggNOG" id="KOG0333">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_11_0_1"/>
    <dbReference type="OMA" id="ARDIKHM"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17945">
        <property type="entry name" value="DEADc_DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000322">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057479">
        <property type="entry name" value="PRP28/DDX23-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25430">
        <property type="entry name" value="DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="433"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="464"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="695"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="433"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMR09631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="869" mass="99362" checksum="BAFB1CDD12C32A8A" modified="2013-05-29" version="1">MQNIIYIMMLLWKQKIKDIFFKVDSFKRRERCEKKAGKLDNFRHIFVLGFNCGIGINLNENMDSSLEKESNMSFMKNIDKTPPLPFIYPPPLPKENLGLPKESQISLREDEAKESFYKKMFSMKTQTLGMFEGLGKLHEFDDTANHNKNTLKDVCNDSISSELKRNEPLSIEELVKKEKELAAMNKPRFLTREQREEIALEKRRMEVKKKGQYIDKMNMNVSKNFFPKDGRNVFFGNNEMNGYTNGTKTILTGSKTMREEMTERQASGSSKLSLKKDDKKSELPIEEKEIEDIRKRYLGTTDNKKKRRKTTERKFVFDWDNTEDTSTDVNPIYSNRHSAQFLGRGRLGGFDDKNNKDYTNSYINVLSRSSNEEDRDRAKQLMELEYKKSSRISWDDMHWSEKPLELMKERDWRIFREDFSISSRGGSIPNPIRNWKESGLPKVILDMIKIVGYKEPSPIQRAAIPIGLQNRDIIGIAETGSGKTASFVLPMLVYISTLPPLNEYNKNDGPYAIILAPTRELAQQIETETKKFSLSMGFVCVSIVGGHKIEEQAFNLRDGVHIVIATPGRLLDCLERRVLVLSQCAYIVLDEADRMIDMGFEEAVNKLLDALPVRNQKPDTDDAENPVLMSKMIGGKERFRQTVMFSATMPPAVEKLAKKYLRRPAIVTIGNAGQAVDTVVQIVEMMNTEDKKRRRLEELLSSNDYSPPVIIFINQRRSCDALAKSLARIGWNAVTLHGGKSQEQRESALSQLRSGEADCLVATDLAGRGIDVADVSLVVNFNMAKNIEDYTHRIGRTGRAGKSGTAITFLTPEDTEIMYDLKQAISKSSISKVPDWLKMHEAAQRKPDKQPVKKPADELLFQIPHGRWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRC3</accession>
    <name>M7NRC3_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873832.1">
        <property type="nucleotide sequence ID" value="XM_007875641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRC3"/>
    <dbReference type="GeneID" id="19895555"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01861"/>
    <dbReference type="HOGENOM" id="CLU_1917948_0_0_1"/>
    <dbReference type="OrthoDB" id="10673352at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="132" mass="16231" checksum="A369B711997B881D" modified="2013-05-29" version="1">MHYKCYNNYLFNFDKKRLKYRKKVLFIKIIIKNKYISIFIFINLFSSQTKSLQDNIWTYDTFDINKGIVIQFNNKRQNFDVSSTDKNLEKIKKSKVFSVQVKIPFSDCIKDFEKELINYCKPYFHRFFSKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRG7</accession>
    <name>M7NRG7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tryptophan--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_01898</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Trp) + L-tryptophan + ATP = L-tryptophyl-tRNA(Trp) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873872.1">
        <property type="nucleotide sequence ID" value="XM_007875681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRG7"/>
    <dbReference type="STRING" id="1069680.M7NRG7"/>
    <dbReference type="GeneID" id="19895592"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01898"/>
    <dbReference type="eggNOG" id="KOG2145">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032621_0_1_1"/>
    <dbReference type="OMA" id="SIYHRFM"/>
    <dbReference type="OrthoDB" id="10261385at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000007">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000033">
        <property type="entry name" value="tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR09711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="413" mass="47458" checksum="B41398A31CFA89AA" modified="2013-05-29" version="1">MEDLNISCLNLKDESTIEESKDQVITPWKVEGRVVDGRTEGIDYDRLIEKFGTKYLDEALLERFERLIGQKLHVFLRRGIVFSHRDFSNILDQYEKKEPFYIYTGRGPSSSSMHLGHMVPFLFCKWLQDVFDVPVIIQLTDDEKYLFRQELKLEDTRRFARENAKDIIACGFNPEKTLIFLDTEFVSGSFYENVVRVSKYITYNKCKATFGFKEEDSIGKYSFVSIQAAPSFSNSFPSIFGKRTDIPCLIPMAIDQDPYFRLTRDVADRLGYLKPSLIHTRFFPALQGHGTKMSASDENTAIYVSDTPSQIKNKINKHAFSGGGATLEEHRLVGGNPDIDVSFTYLKYFLEDDDQLEQIRNDYSSGKISTGELKAITINVLQKFVAEFQERLQLVTDHTLSLFLDSNKKLKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRJ8</accession>
    <name>M7NRJ8_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01658</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873619.1">
        <property type="nucleotide sequence ID" value="XM_007875428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRJ8"/>
    <dbReference type="STRING" id="1069680.M7NRJ8"/>
    <dbReference type="GeneID" id="19895352"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01658"/>
    <dbReference type="eggNOG" id="KOG3230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069208_1_0_1"/>
    <dbReference type="OMA" id="KENQMSA"/>
    <dbReference type="OrthoDB" id="10252926at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="221" mass="25860" checksum="09264089B2159FD5" modified="2013-05-29" version="1">MNILGWVFGGYITPQEQLRKHRRALEKAQREIQREEIKLEAQEKRLIGEIRKSAQAGEMEVTKIKAKDLVRTRKQIGKFLQIKTQLQAISLRIQTVQTHEQMTQSLKNAARLLNSMNRKIHVPTLMKITQNFQQENDIMDQREEMMDDAIDDIMEDDDMENNDIINQVLDEIGIDLQQDLNNIPSITNTIHKGRQKIPQMINGSGNNQHDDFQERINRLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSC9</accession>
    <name>M7NSC9_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fe-S protein assembly co-chaperone HscB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00096</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HscB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871953.1">
        <property type="nucleotide sequence ID" value="XM_007873762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSC9"/>
    <dbReference type="STRING" id="1069680.M7NSC9"/>
    <dbReference type="GeneID" id="19893794"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00096"/>
    <dbReference type="eggNOG" id="KOG3192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068529_1_1_1"/>
    <dbReference type="OMA" id="CRCIQPV"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.20">
        <property type="entry name" value="HscB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004640">
        <property type="entry name" value="HscB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036386">
        <property type="entry name" value="HscB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009073">
        <property type="entry name" value="HscB_oligo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00714">
        <property type="entry name" value="hscB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021:SF15">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07743">
        <property type="entry name" value="HSCB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47144">
        <property type="entry name" value="HSC20 (HSCB), C-terminal oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="33"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR11658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="202" mass="23748" checksum="EC899AC0F844D4CA" modified="2013-05-29" version="1">MNKKCENCLKKCNSWDLICSSCLLLLKLPSSIHFYKIFPKSLKEPPPDGDFQIDTKQLHKEYLEIQKKIHPDIHAKNGDKQRMLAESLTSTLNTAYSTLVDPLSRADYLLSFYNIPILDENKTHQDTTFFSKIMKLNEEIENSKSQADIQSIQRAIYEEIKKEIMEIRSGFKTMDFQIIKQATIRLKYWTNMKHTLQEKSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSD5</accession>
    <name>M7NSD5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcriptional regulatory protein DEP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00101</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871958.1">
        <property type="nucleotide sequence ID" value="XM_007873767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSD5"/>
    <dbReference type="STRING" id="1069680.M7NSD5"/>
    <dbReference type="GeneID" id="19893799"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00101"/>
    <dbReference type="eggNOG" id="ENOG502S36P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_447671_0_0_1"/>
    <dbReference type="OrthoDB" id="20886at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21964">
        <property type="entry name" value="BREAST CANCER METASTASIS-SUPPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01401">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="210"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="536"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="225"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="610" mass="70243" checksum="6A52B11AA7CB51D0" modified="2013-05-29" version="1">MPRGRGRHHDREIIIEKGMVSNQNSAGIWSGKRLRRGRGRISKKGETLSSPVFSGSSVFRENYLVENSMEGLGSSKNAYILYGSKYKNSEENTLVGEPLIDTNQTRQDNMNELEAISVLDGFSNSVSVVDSSYIKKPKNNNSDDDLSSLSELNDSEAETERIEDIDSSLEVHMINKKLIEDQKNPDINESESSQPFTSFNKKYKKDKSELFGPPEFLSSSSNEYVSKKDSKSDGDDDSVHSKTIPSLDNESTVEEEIMESVFGDDDISMNVDDEVDEKKVQKRKDAIAALTQIEIQFAKLRDKLYENQISCLDKEVDLVNKGIHPELSSLMEKIAERRERKYNIAVAFRDMSIKFIKDEFIAHQYEIQNSFLESKRKLREKMLQRTGEKCFQIYHERRLMETLAPEYGFSIPTKRLVQLKNRRAHELEVMFLVGLKTYIGFPAAPEIKNASKEEIMQDLSEMKVKRAPFDSFRNFIFPNSTLQNTSSHNQESQLKSYNNNLFSQFLYQKSSQSRQYSNCMTSHSLSEYSSLKQHSLNTYPPYNSDRNQPSSHDQYHSSFCMQHEQASVDMQLMGNKPFCQFPLSPRLNQSLQYFEPLQKKNDYIGMILHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSF5</accession>
    <name>M7NSF5_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873409.1">
        <property type="nucleotide sequence ID" value="XM_007875218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSF5"/>
    <dbReference type="GeneID" id="19895166"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01470"/>
    <dbReference type="HOGENOM" id="CLU_430898_0_0_1"/>
    <dbReference type="OrthoDB" id="5416950at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="635" mass="71520" checksum="837CC3F1D3D7361F" modified="2013-05-29" version="1">MLGRFFGIEYKSQESSLNKYLGKRSDIYEDVSRKSTGISMGLRCSFYFLEFKENMKLVKKMFSGLKDLVFFKYTLKSKIISSSEPYESIESSETKSLVLLGFSNPLTRRHVENTFLFKDVDKSKLENDSKADSNDFSGYFSKRALDFLDLDDKNATKTNVAEMTKTNVAEMTKTLDLSSNITFTTKTREPTTTKGTFTTILSETTEVSTSTIKLSAQRSHARSNDNLYMILGISSIAILIIIVIVFLVIYGVRRSLKKQEMIEDMVYENEMSAHAKLMEAASTPVSEKTSSTPTSISLSAPILGSRNSNDLYSRRGTYFDSNGIYGSKNGEKQDEQTLHNSSLKYYGMSQSTNNCPTSSRTRNSSYYNPSGQPTRSLSLSSRSKDYFGAHSHSSNVTSTYDDSFQKDRVRLTSCNNDMNGSSFGKASSNHLRTPNSVYLSGDQNRGYPASSQIRAGPLDSRGINRFLSQESLRSSRAHFATQPNTLNYKNSFKTLGTNFQMESSNFDTPNSHLSELSNNVSSPLFTYKDSLGSSSCYDSSFTNERMTPKSFFSRENMKNESYTPNSSFEKMFPKNTNKHSPNKDYMRTPSVYASVGIWAEKKRKLLDLTSNLNESSSNRFYEGMNTRQGHNINKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSF7</accession>
    <name>M7NSF7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Symplekin/Pta1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_00120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871978.1">
        <property type="nucleotide sequence ID" value="XM_007873787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSF7"/>
    <dbReference type="STRING" id="1069680.M7NSF7"/>
    <dbReference type="GeneID" id="19893818"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00120"/>
    <dbReference type="eggNOG" id="KOG1895">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AREMCLN"/>
    <dbReference type="OrthoDB" id="331600at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021850">
        <property type="entry name" value="Symplekin/Pta1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032460">
        <property type="entry name" value="Symplekin/Pta1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245:SF20">
        <property type="entry name" value="SYMPLEKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245">
        <property type="entry name" value="SYMPLEKIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11935">
        <property type="entry name" value="SYMPK_PTA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Symplekin/Pta1 N-terminal" evidence="4">
        <location>
            <begin position="85"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR11683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="739" mass="85873" checksum="B823EFB77529B3AD" modified="2013-05-29" version="1">MNEETTIQLSQLNTIWELVEQDASFFMQIVPGILPIAARSELVIRQWIAKFFALLFTTPNLSIDNKEKLGLQCLDTLVNYVQFDDVVLLKNIIQSCSAFYPIIFRYICMQHNISIWNQMILIKNRILQLWDSKHKGIRISCIKFVQKIIQTQTFGTKDPRLIDKSDISLNLIPPKHPFLHSIDLEAEAKGFLDRLIENIYEKPLDPFIISATLNCLTVLAKHRLDTNTKIINGILGFNPIDDTIKASDDIKMQIQIRSLIKNITIVLTNLLRNNSTGSLASKVSQYLSTQEKFDMQDDVSRKRFFSDITHFSAKRIKTENLNTQKNIEVHHDLSIISLFTLNQMKKDNPLLSIDVTQLPHELVARITIENLLYIKHDHFERCINILRSKLLEHSHQITSKIEDNKSVKEALANITDVEDDDFESSEASIYQSNKNIAKIRDLQVKQEKNYQEKGMKTISFELPDPQPLTPSLITKHFHNVMDRLFLNAFKNTTSDDQKPTRILDLENLKTNKWNKQSWIRLISRLCTRGLVTSNDIHKNNYKDQISFSHFVRNKLLEYVLSYFKERIQFAVTWLSEEWYNDHLMLRKSKEERLTWEGPQYEKWTLMVLDGVLPFVDGSNKAFLRFLSDLPELSETCIHRLRILCLDPDRSKLGFAALQYLIMLRPPVRSICLDFIQKLSSENPDSDFVIPIERILSKYRTYLIPSQTLQIPINSNSSINHSSDSFNISPSEITFPQQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSG2</accession>
    <name>M7NSG2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chromatin assembly factor 1 subunit A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01475</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873414.1">
        <property type="nucleotide sequence ID" value="XM_007875223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSG2"/>
    <dbReference type="STRING" id="1069680.M7NSG2"/>
    <dbReference type="GeneID" id="19895171"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01475"/>
    <dbReference type="eggNOG" id="KOG4363">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028547_0_0_1"/>
    <dbReference type="OMA" id="YENVRPP"/>
    <dbReference type="OrthoDB" id="79480at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048800">
        <property type="entry name" value="Cac1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022043">
        <property type="entry name" value="CAF1A_DD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272:SF0">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A CAF-1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21796">
        <property type="entry name" value="Cac1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12253">
        <property type="entry name" value="CAF1A_dimeriz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromatin assembly factor 1 subunit A dimerization" evidence="6">
        <location>
            <begin position="304"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Chromatin assembly factor 1 subunit Cac1-like C-terminal" evidence="7">
        <location>
            <begin position="483"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="355"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="65528" checksum="1712E8575A1465FC" modified="2013-05-29" version="1">MLNSDCISIVEDKMIINSFELDKETEDISMKRKVEETKVKKIEENTGKEELEEKSNRRSKRIKGMKSDLSNELKDSIKKEEKKQRKEMKIIREIERKKEREEKEERRKKERIEREAKKEMEKEKKEAERLRKEKEKQLKEEERLKKKAEKDAKDQKKNEAKKKKEEKRENNIEKSDSQLKLQYFFYKTFPKENAIEIKDCFSSDYEKCFIPFFVKQYTLLSSQHAFVRNPDERMTIMKDMDMFLDSDFSIMSPIEHLLSLFKIKPALSFRHPKSHITVKYLLQKYEQSDSTEDLFNKLKIFPMKLLQFREDVRPPYYGTFSKSSFILTPRNPFKTDEHLFNYNYDSEAEWIEEEEGEDIDNMDDSEEEEDAAALKEDEDDRDFLDDEGELNNTKKKVIINLIPSVKGLYWQHSDNIDTDDYELFKKFRMNSLLDINLPINPYQDYWSPESNSNNDAKLQNSTIKTISSVLSPKPSLHFPQDSLPSFLKIIQGSTQTKVLLVETLRQKFSDISKQAIQWKLSTVARRNGKGVNNTWAVDPSVWHSVFGDDQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSV2</accession>
    <name>M7NSV2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="5">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01605</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="5"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873562.1">
        <property type="nucleotide sequence ID" value="XM_007875371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSV2"/>
    <dbReference type="STRING" id="1069680.M7NSV2"/>
    <dbReference type="GeneID" id="19895300"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01605"/>
    <dbReference type="eggNOG" id="KOG0813">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_4_0_1"/>
    <dbReference type="OMA" id="CKERARF"/>
    <dbReference type="OrthoDB" id="515692at2759"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01374">
        <property type="entry name" value="Glyoxalase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017782">
        <property type="entry name" value="Hydroxyacylglutathione_Hdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03413">
        <property type="entry name" value="GSH_gloB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF94">
        <property type="entry name" value="TENZING NORGAY, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="10">
        <location>
            <begin position="12"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR10352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="251" mass="28709" checksum="43BFB0EC9581A0F9" modified="2013-05-29" version="1">MRIVPLEILKTNNYSYIIICNKTLEAAIVDPAEPAVILPYLERLKNEKIHLKSIITTHHHWDHAGGNRKMLESYPYVKIYGGKDSEAVNHYVKDKETFKIGEIFVKSLHTPCHTKDSICYYAEDEREKAVFTGDTLFNGGCGKFFEGTPEQMYKNLNEILGSLPGDTKVYPGHEYTKSNLDFAKTIFSSDKLSEVSRFADANRITCGKFTINDEKTYNPFMMVNSICIQKVIGESDPVKVMKQLREMKNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSW7</accession>
    <name>M7NSW7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FMP27 GFWDK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01623</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873581.1">
        <property type="nucleotide sequence ID" value="XM_007875390.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NSW7"/>
    <dbReference type="GeneID" id="19895317"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01623"/>
    <dbReference type="eggNOG" id="KOG1910">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000592_0_0_1"/>
    <dbReference type="OMA" id="IQLKWNN"/>
    <dbReference type="OrthoDB" id="1562405at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019441">
        <property type="entry name" value="FMP27/BLTP2/Hobbit_GFWDK_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019415">
        <property type="entry name" value="FMP27_SW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019449">
        <property type="entry name" value="FMP27_WPPW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045167">
        <property type="entry name" value="Hobbit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678">
        <property type="entry name" value="ANTIGEN MLAA-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678:SF6">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10344">
        <property type="entry name" value="Hobbit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01214">
        <property type="entry name" value="Fmp27_GFWDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01215">
        <property type="entry name" value="Fmp27_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01216">
        <property type="entry name" value="Fmp27_WPPW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 SW motif-containing RBG unit" evidence="3">
        <location>
            <begin position="1063"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit" evidence="2">
        <location>
            <begin position="1183"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 WPPW motif-containing RBG unit" evidence="4">
        <location>
            <begin position="1597"/>
            <end position="2107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR10372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2737" mass="320217" checksum="A05FEBF549B28757" modified="2013-05-29" version="1">MEIFVENILLWIGIFFLNYILLTHILLKVIKKVGGVHIRRFGYFSIHGIELCYKEYANLYVESVRVHFHRPRLATKRWISFSVKEIFINIRKPCKEREEILKKKSSNNFFNKYIQKSIYFVFNIMKSSIIFKIKDWVDIIIIDTSINIEDYGKFFITTFNMHFNNTSYYNTTSGIYTGRFSKLLSREKRFEMINIVDSILFISKRGTSSELIDKILINIQGKLDHIIKNIKFSLKCGKFILPLDEFTNNNDINYFFNNKTDSFISTLNNYFKVKDESKEPIMELKENMVEKMHWFNIIHEIQFHVGNLKIKKSITFSSSKNNSSFLLLRLKEIGINIHHIGKNSSIYRQFFDVPASHQILASCISLSISIFQKTVQEKEADFILIPMITFACKISTLDHLVKSNMVTKGLHITNIIANISITSPSIDLRFERLLSIVSIFESRNVIHTSVFSKLQLLKDFIPKLNFNFSIYEPVIRILLPFNNSLYENSKQRPTILILSLSNIFLDLQTNISGNDISRFFSVNTSILFISQKLYYHTSFKGKYNILTIENFTLHFKFDLSPFNNVSIGIFHENVIFNLNNIEIIYCLNNIFYSISNIRYDYLSEKNIGLLDMFLLYKCSLLLRKIEFHGSKLDIYLFGNEPRITHDHKGILLRLDSWKIEYCFLNMISKELLFSIYKESKSPNFQHILNTFVFNTIPSSRGTLLLNGFKIFAIHAENVLDMKEPIIEVIKYGLTFVTEPNKDHLLQIIIELDQLCLTYSIFKYYTILLALKILEKTFFQENIFKTSQGYHTEDNGQVNNLLWGYIFVYISISSVKVKIELPSKQFLMLNMHKLEISHNKDEFLSCKAGNIVLCVPSPVIQKFWDRIVNINTLTIYYKRIKIDQKNESTIVLYADAIRIRIPHKFVLHSMVESIQNNIKSVKQLYYCFFISSNSSTLTNHPVKAKVIPRIQLESSFISFDMEDDPFEARLGLIWRIGLIEQKARIMRETTFDIKAEKIKDESELINDNEQTKTDNENEYFLGTSFEKSELKQLYNKQDSHIKNVKDVQDFSESKFSNLSSKAEQAYEKLQEYNSHSWIKKFQKVNNLQSFKLYSIRHRHWTLDGIKCISTFQENILPLPTRPPLLSILFSKVEFIFDKPSFPIENLYQFLRDTGKGLPLETKFSVLIPFNFSWKMAEAKICLRDYPLPLIYIPDSNSLRPQNFPTWEFSSDLVIAEQFSEKESIRYVEVCIIPNNSGKEGSSFNIKVARTITPVKIYGVVDVNINTLYPTQITWGMSLQPAIQDIMRIFGTFSRPFEDPSDKLNFWDKIRLIMHTSFKFKWKNDGNVYLTLKGSRDPYLITGDGAGFIKCWKGNVEWSVGCSLDSRNFMVIISDEFLLAIPDFIQQAQSLMNWPNTIISAYDNLTNNTYQKNAIHFQKIIMKLKGGVKWTAGLVFEQHCDDACQNCYGKYQCRIFHFKPHYKIILRIPKFAFSENGQKYDAFKGFRSHYIHGSLSIICPIDVSLPDSKFNEKIKSYNAIHLTPKVFQHFFNWWSLFSGIMSFPLKSGKLFLFPHTKKKINRYLMTFSYKLELSPLFLSHIYNYRTDIDWVDKTFTSIGIKGKTEKFILDVHQKKDLQFKKLHKTRKDEKLIIDNATINFTSTDLKVILSRFNEVDIEDSNKFRYDSQKSHDFRMIFQKNNSNHFIVDEDLKWVDIDDFIDLDLDFSLKSAPVFQILPLAYIPQFIYFRETNNHCNGSGPENICLSKYQFRNGDTHFCILNNKKDPYDIQVELIQKRQNEIMRRISRNKNKLSCIENVISKKSKASILKSQYKKIIDENAMLFDKHNFINAMLLHMKADQDNKLTNEIDMSADNHHISSDVSENFRALSKETISEHFSDFNNRFFVYNIQLKWYNSVRNILLSYIHQITQREGFVYYMSQKAVKFITDLIKEQIKLENSLSMMTNEKIINKQGFNDQEINELIDGLINDTNNDFKDEKNNKKSFSSIDNPFFRDDFDYILSKNYDCQHSYIVKLFAPQIQLQSEKNNQAVAIITAQNMQLKVFSIIDKNMVDDTVSGLLQHRFIVKMNNAQIFVSKKNDFIENSTNFFYTNSYGSLQSNWSPWVPLESIYDFTGTPLAFTRIIDQTSASLGFIKYNHLRLKKNELNHNKNDLFESFKIESPEKYVNNIFVDFPKIIFTANSDQYYIIFLIVTDLLIYTEPAQKEKSKRLEKLMLAVDFSDLTGTAEMVVNLQKRIRNLEEIKTQHRLYYENYNMEQRLLRMKIEAELRDCEDELFYLMKSIAASQKHDGSIIENVANMSWLLSASEVVWHGLLENNKPFVDFGLSNATYQRTDNFDGSNFNILEIEMIQGINLLPKTCFPDLLSPYFCGSKSVLHGRKKKMIRIYWHMLDSIGGIPVMDHFEVNLFPLSIKLEHEVGKKIFDYVFPGRGVVNFIAQEKSSPLKKDINADISSTENYYKTDISRPFYSSRSSSFSLLMNSIKSPIESFSCLSKLSRESIKSNSSFQIFYDSEDPYGIESLKLSKSETQITDSNAFEKNSRISNKPYYKPNDDLNQMVLRANNNMTLLYVKVPSLILCLSYKGPRKKNIEDLNNFVFCIPTIEYRNKTWSYLDLVLHIKKEIIKAIIGHTGSLVKDKFIQRRSREKLSQIKREYIPFKINMPLNYKNKNTELQKMSSNIIKSNLTKINCLHSNHKHHLHNFSERSLSCVSHLVEYNDTEESEESRVKKAKMLLGKFIDPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTS2</accession>
    <name>M7NTS2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">serine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01371</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873301.1">
        <property type="nucleotide sequence ID" value="XM_007875110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTS2"/>
    <dbReference type="STRING" id="1069680.M7NTS2"/>
    <dbReference type="GeneID" id="19895068"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01371"/>
    <dbReference type="eggNOG" id="KOG2509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023797_4_3_1"/>
    <dbReference type="OMA" id="EQNCIDR"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070158">
        <property type="term" value="P:mitochondrial seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="195"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="290"/>
            <end position="292"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="306"/>
            <end position="309"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="377"/>
            <end position="380"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="8">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR10672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="457" mass="52244" checksum="17C843EE35B5AFB8" modified="2013-05-29" version="1">MMQKDFQYGRSIKKIFRACIDYRYIRDNADEIKSICLKRNSKASFDNVSRIINLYQTYLGYIKLRDNLLNQRRCLTNTIKQEISSGNDIFQQGFIRHASEIKKDLQKVKENIYFTQSELLQLVLTIPNNIHPLSPIGSEENAKIVKYINSDKQFFISKPKDHTVIADMLELIDFDSASKTSGHAFYFLKNEAALMELALINYVLEKAINAGWKLVIPPTIIRSEVVSACGFQPRDDYNDKQIYFLQSPNTELKYCLSGTSEIPIAGMEINKILKGSDVPKKVVGISRVYRSEAGSRGKKSKGLYRVHEFTKAELFAWSDPKKSDKILEDILNLEENIIEELGLYGRILDMPTFELGASAYRKYDIEVWMPGRGAWGEVTSCSNCTDYQTKRLNTRYMAYPGDKLGWPHTLNGTLAAIPRLIIAILETYQNDDGSIRIPRVLQKYMGGMTNIVIKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NU01</accession>
    <name>M7NU01_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00891</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRM CPSF6/7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872802.1">
        <property type="nucleotide sequence ID" value="XM_007874611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NU01"/>
    <dbReference type="STRING" id="1069680.M7NU01"/>
    <dbReference type="GeneID" id="19894589"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00891"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033916_1_0_1"/>
    <dbReference type="OMA" id="IECHSHE"/>
    <dbReference type="OrthoDB" id="10065185at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034772">
        <property type="entry name" value="CPSF6/7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23204">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="88"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="178"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="37"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="311" mass="34569" checksum="0394FA6BDB01E0C9" modified="2013-05-29" version="1">MEEDNFDIDIYEDEPLTYEETKEQEDFEQESFKATEIDRDENKLDSCEININKSENEGEKTTENINTLETSEETEKIDTRPIDTCATTALYLGEMNWWNSDEDIRNVVLEAGIDCELKDITFNEHKVNGKSKGIAFVEFTTPQAATAVKLFLENTTNPAYMNGNKKFSVSFSSLSNPFRTLPKEPPSKTARGRNDMASTNTRGLARGNANNRNITGYGNRMNNAGIQGNMMMTGLPGRMPFPNMMPFGTYSQSQNAAASGFNANMIGYGGFGGSQGFPAPHFNPAFFGNAQDPNTFSDANPHGQKRQRGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUD9</accession>
    <name>M7NUD9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PNEG_00871</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872781.1">
        <property type="nucleotide sequence ID" value="XM_007874590.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NUD9"/>
    <dbReference type="GeneID" id="19894569"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00871"/>
    <dbReference type="eggNOG" id="KOG0260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000487_1_1_1"/>
    <dbReference type="OMA" id="KPCMGIV"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140463">
        <property type="term" value="F:chromatin-protein adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180034">
        <property type="term" value="P:co-transcriptional lncRNA 3' end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019985">
        <property type="term" value="P:translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02584">
        <property type="entry name" value="RNAP_II_Rpb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02733">
        <property type="entry name" value="RNAP_II_RPB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.140:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000684">
        <property type="entry name" value="RNA_pol_II_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007075">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007073">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038593">
        <property type="entry name" value="RNA_pol_Rpb1_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04992">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04990">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05001">
        <property type="entry name" value="RNA_pol_Rpb1_R"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00115">
        <property type="entry name" value="RNA_POL_II_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 15 18" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="17">
        <location>
            <begin position="236"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1477"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1601"/>
            <end position="1666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1477"/>
            <end position="1496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMR10721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1666" mass="186234" checksum="9475DA45AD678C78" modified="2013-05-29" version="1">MSGDIALAPSSAVLRQVEEVQFGILSPEEIRAMSVAKIEYPETMDESGHRPRIGGLLDPRLGTIDRNFRCQTCGESMAECPGHFGHIELAKPVFHIGFLVKIKKILECVCLNCGKLKADESNPKFVESQRYRDPKSRLIAVWNVCKTKMICEIDPPVNDDYGVKSIIGHGGCGNPQPIIRKDGLKLWATYKKSKDSESDLPDRRLLTPLEVYTVFKHISSVDLEKMGLNEEYARPDWMIITVLPVPPPSVRPSISVDGSNRGEDDLTHKLSDIIKANANVRRYEQEGAPAHVVSEYEQLLQFHVATYMDNDIAGQPQALQKTGRPLKSIRARLKGKEGRLRGNLMGKRVDFSARTVITGDPNLSLDELGVPRSIARILTYPETVTPYNIHKLQELVRNGPNEHPGAKYIIRDTGERIDLRYHKRAGDIPLQYGWRVERHITDGDVVIFNRQPSLHKMSMMGHRVKVMPYSTFRINLSVTPPYNADFDGDEMNLHVPQSEETRAEIIEICMVPKQIVSPQSNKPVMGIVQDTLAGVRKLTRRDNFLSRDQVMNILLWVPEWDGNMPSPAIIKPKPLWTGKQILSMVIPKGINLIRDDEKQTPMTPDDKGMMLEDGEIIYGIVDKKTVGASQGGLVHTIMREKGPEVCRVFFNGIQMVVNYWLLHNGFSIGIGDTIADADTMRDITNTIAEAKAKVQEIILDAQQNRLQVEPGMTLRESFESKVSRALNQARDTAGRSAEMSLKESNNVKQMVTAGSKGSFINISQMSACVGQQIVEGKRIPYGFKHRTLPHFTKDDYSPESGGFIENSYLRGLTPQEFFFHAMAGREGLIDTAVKTAETGYIQRRLVKALEDVMVKYDGTVRNSLGDIIQLVYGEDGLDGISVEYQNLDSLRLSNEEFDRRYRVDVMDPEKTIFPQYLETGNEIDGDMAIQNLLDQEYNQLCEDRELLRNFIFKDGDGRRPLPVNIQRIIRNAQQIFHIDKRKASDLSPRDIILGVNETIKKLTIVRGNDKFTKEAQENATLLFQILLRSRLASRRVIEEYHLNKIAFEWVLGEIETRFAHSIANPGEMVGTLAAQSIGEPATQMTLNTFHYAGVSSKSITLGVPRLKEILNVAKTIKTPSLTVYLMPEVSRDMESAKQVQTAIEHTTLRTVTSVTEIFYDPDPRQTVIEEDRAFVEAFFAIPDEDVEANLHRQSAWLLRLELDRAKMLDKKLSMSDVAAKITESFHKDLFVIWSEDNADKLVIRCRVIKDDEKSFDDDDNLVEEDMLLKRIESHMLESISLRGVPNISRVFMMEHKTVYQKENGEFARGQEWVLETDGINLAKVMAVENVDPQRTYSNSFVEILQVLGIEATRAALLKELRNVIEFDGSYVNYRHLSLLADTMTSRGHLMAITRHGINRAETGVLMRCSFEETVEILMEAAAVGEMDDCRGISENIMLGQLAPLGTGEFDVMLDEDMLNEVVIDRQMFRGISSTALGKTPLQDDQATPYDSRSPVSDSGYIGSSDGAAFSPLVQSGSETPGGFTEYGGGFGVSPYGATLQSPGYQPFFPFSGTSPVSPTYSPTSIFSPTSPQILRMSPNFSPTSPMCSPISPAYSPTSPAYSPTSPVYSPTSPVYSPTSPAYSPTSPAYSPTSPAYSPTSPAYSPTSPKFSPTSPAYSPTSPRHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUH8</accession>
    <name>M7NUH8_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">U4/U6.U5 tri-snRNP-associated protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_01102</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873014.1">
        <property type="nucleotide sequence ID" value="XM_007874823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUH8"/>
    <dbReference type="STRING" id="1069680.M7NUH8"/>
    <dbReference type="GeneID" id="19894799"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01102"/>
    <dbReference type="eggNOG" id="KOG2026">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016848_4_0_1"/>
    <dbReference type="OMA" id="DGCFRVF"/>
    <dbReference type="OrthoDB" id="10263353at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02669">
        <property type="entry name" value="Peptidase_C19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033809">
        <property type="entry name" value="USP39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF16">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="218"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR10957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="546" mass="64475" checksum="C1AD966AAE84B2D4" modified="2013-05-29" version="1">MKSNLLKMLKRKISEDFETSIHKEKLEYQEKNKKEKGDNLFLGKKDDFKRDNLTVSNNLEQIDENIKKKKEKIESLPTPPLNMYLDTERWIEHDWILILKNYVQFLYRISMFMHALYAGNTFKEFLLFFAIFFLIELGRGRSSHAYFHSLDEAHHVYINLHNLKIYVLPESYEVHTNALDDIKYVLNPTYTKEQVIAMDMNIEPSYDLDNKRYLPGFVGLNNIKQNNYLNCVIQALSHITPFRNYFILENFDGKSELVQRLSILIRKIWNAKAFRGHVSPHELLQEVSSVSGKQFKLTEQSDPLKFLSWLLNIIHRDLGRSKTKVKSSIIHRIFQGRVRIQSQQIIAKSDANDADRLRFEIGREIKENILPFLFLTLDLPLPPLFQDEFEDNIIPQVALSTLLAKYDGITSQELSGQRKRYKIVKLPPFLIFHIKRFTKNNWRNEKNPTIVNFPIKDLDMRGYIDPIPPPNVSTVYDLSANIVHETVSSMEGDKRVFRTQVRNKSNDTWYQIQDLFVEEIPKEMIFLGESYIQIWERRNHKKKAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVA8</accession>
    <name>M7NVA8_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872718.1">
        <property type="nucleotide sequence ID" value="XM_007874527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVA8"/>
    <dbReference type="STRING" id="1069680.M7NVA8"/>
    <dbReference type="GeneID" id="19894509"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00811"/>
    <dbReference type="eggNOG" id="ENOG502S1HE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040321_2_1_1"/>
    <dbReference type="OMA" id="LNCFQYF"/>
    <dbReference type="OrthoDB" id="431202at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022127">
        <property type="entry name" value="STIMATE/YPL162C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735:SF1">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12400">
        <property type="entry name" value="STIMATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="225" mass="26289" checksum="AB09E6FC6BCECCDD" modified="2013-05-29" version="1">MKNVQKEILDCRILSPFSLFVQEILGAFVLFSLLIKRHWEYPRRSFRIWFFDVSKQIIGAGVIHILNILISDIIGFNQEHGFSNPCIWYLLNIMIDTTIGVPILWIVLGFIGRICKSMGCIGTKSGDYDGDPPRITWWWKQLFIYIFGLICMKISVYPILRIPMLDNTANWLLSWTSSEEKLQIFFTMFFIPLIMNILQYWIVDTIIAKKQGHIALNCVKGDNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVC2</accession>
    <name>M7NVC2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein S14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00685</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872583.1">
        <property type="nucleotide sequence ID" value="XM_007874392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVC2"/>
    <dbReference type="STRING" id="1069680.M7NVC2"/>
    <dbReference type="GeneID" id="19894383"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00685"/>
    <dbReference type="eggNOG" id="KOG1741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139869_2_0_1"/>
    <dbReference type="OMA" id="FGLCRNQ"/>
    <dbReference type="OrthoDB" id="413436at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1480:FF:000001">
        <property type="entry name" value="30S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_uS14_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006477">
        <property type="entry name" value="PRK08881.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836:SF19">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR11086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="11737" checksum="B1782695F2208194" modified="2013-05-29" version="1">MKCRVLRDFRRRIAVAQAEPLRQALRYIVRNTTLPAQVRIRAQQRLIEMPSDTRTTRVKNRCIESGKGRGIFRDFRLCRYQFRLNALEGYLPGVQKASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVX7</accession>
    <name>M7NVX7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00296</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872168.1">
        <property type="nucleotide sequence ID" value="XM_007873977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVX7"/>
    <dbReference type="STRING" id="1069680.M7NVX7"/>
    <dbReference type="GeneID" id="19893994"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00296"/>
    <dbReference type="eggNOG" id="KOG0372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_0_5_1"/>
    <dbReference type="OMA" id="FREFPHE"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901525">
        <property type="term" value="P:negative regulation of mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="6">
        <location>
            <begin position="136"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="338" mass="39213" checksum="78742204EE85EA53" modified="2013-05-29" version="1">MDIDVYIEKLYRKELLSEPIIEAICESVKRLLIKESNVVHICSPVTVVGDIHGFNIYFFEIFFMKNRQFYDLIEIFKIGGFCPDTNYLFLGLLIFFLVNKNKNVLGDYVDRGLFSVETISLLVCLKLRYPERVHLIRGNHESRSVTQTYGFYTECIRKYGNVNVWHHFTNMFDFLTLSVIIDNKIFCVHGGLSPSIHSIDQIKIIDRFQEIPHEGPMADLVWSDPDQDKNDFSISPRGAGYTFGIDIVEKFLEINDIEHILRAHQLCHEGYQILYDGKLSTVWSAPNYCYRCANLASILEIYDNGQKKFNVFDAAPENEHDNPSTQNNQTKLSVEYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NW18</accession>
    <name>M7NW18_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">enoyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="11">1.3.1.104</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_00340</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.104"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.104" evidence="11"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872213.1">
        <property type="nucleotide sequence ID" value="XM_007874022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NW18"/>
    <dbReference type="STRING" id="1069680.M7NW18"/>
    <dbReference type="GeneID" id="19894038"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00340"/>
    <dbReference type="eggNOG" id="KOG0025">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_17_0_1"/>
    <dbReference type="OMA" id="YGYTQSK"/>
    <dbReference type="OrthoDB" id="7482721at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08290">
        <property type="entry name" value="ETR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000112">
        <property type="entry name" value="Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051034">
        <property type="entry name" value="Mito_Enoyl-ACP_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981:SF2">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="38"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR11311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="375" mass="42454" checksum="64383C07E15E7E9E" modified="2013-05-29" version="1">MNINKEMLLRPLTKYFLNFQSRNISGKAIVFSNYGNPSEVLQLHNYNIETNPLKPILVKFLASPINPSDINQIEGVYPEKPSFTKDLGTDFPCSVAGNEGVVEIIENMDKKSEFKPGKRAIMKNPGFGTWRTHAIADPNDLLFLDIDDVTAIQAATLSVNPCTAYCLLKNFYKLKPGDYFIQNGANSHVGQAAIQFGRIWGLNSINIIRNRSNIDKLKSFLYDLGATHVITDIELANKEFMEELVKKCCGESGIPLGLNCVGGKSILDLARYIKPNGHIVTYGAMSRQPLLMSSGILIFKNVHLHGFWITKYNRTYPEKRLKILNNILTYIKNKSFKDLLCDKVYLDKSLQDLIYMKTFKNALENKERKQVLVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7NW41</accession>
    <name>M7NW41_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872243.1">
        <property type="nucleotide sequence ID" value="XM_007874052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NW41"/>
    <dbReference type="STRING" id="1069680.M7NW41"/>
    <dbReference type="GeneID" id="19894068"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00370"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076142_1_0_1"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710:SF243">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA-2 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="117"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR11341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="179" mass="20798" checksum="949812B8C8C0A91C" modified="2013-05-29" version="1">MVLFSQVIPIENKMSTYQDEHYVENEQKKQNSLSEIIKHRKNIASFLQETKQQKRDTFFSEMNNIFQGYSNASSSALDLLMFQSINDLKNTESGLPDNFMDTLDRVPKKVLKKDDMCSICKTSFLEDKYPFVVKLPCGHKFDECIGVWLKISATCPVCRKLVLKERPIVSQDEYDDIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NW89</accession>
    <name>M7NW89_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00011</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871862.1">
        <property type="nucleotide sequence ID" value="XM_007873671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NW89"/>
    <dbReference type="STRING" id="1069680.M7NW89"/>
    <dbReference type="GeneID" id="19893709"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00011"/>
    <dbReference type="eggNOG" id="KOG0817">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118853_4_1_1"/>
    <dbReference type="OMA" id="RYKFEAW"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000010">
        <property type="entry name" value="Acyl-CoA-binding domain-containing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="3"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR11567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="87" mass="10121" checksum="766138431CFC1C0E" modified="2013-05-29" version="1">MSLIEEFEQAARDVKRLSSTPSDSELLELYALYKQVIEGDINKERPGFFDPKGKCKWDSWNKQKGKSKEDAMKEYVNLVNALKEKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWH5</accession>
    <name>M7NWH5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein NSA2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00085</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
            <location evidence="1 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871942.1">
        <property type="nucleotide sequence ID" value="XM_007873751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWH5"/>
    <dbReference type="STRING" id="1069680.M7NWH5"/>
    <dbReference type="GeneID" id="19893783"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00085"/>
    <dbReference type="eggNOG" id="KOG3163">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1070048_0_0_1"/>
    <dbReference type="OMA" id="TNTPEND"/>
    <dbReference type="OrthoDB" id="1847590at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11381">
        <property type="entry name" value="NSA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.310:FF:000001">
        <property type="entry name" value="NSA2, ribosome biogenesis homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039411">
        <property type="entry name" value="NSA2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12642">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="260" mass="30036" checksum="D22A428AA0BF842A" modified="2013-05-29" version="1">MPQGDYIENHIKKRGRRLDFEERKRKREAHLVHKKSECSRKLRGIKAKIYNKQRRQENIKMRKLIKEHEKRNIKEKIPNSIPDGAVPTYLLDRGDEKQAKILSNMVKQKRKDKEGRYSVPLPKVRGISEEEIFKVIKTGKSKKKSWKRLITKATFVGEGFTRKPVKYERFIRPMALRQKKANVTHPKLAVTMQFPILGVKKNPQSPMYTQLGVLTKGTIIEVNVSEMGLVTPGGKVVWGKYAQITNNPENDGCVNAILLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWP0</accession>
    <name>M7NWP0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Guanine nucleotide-binding protein subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00015</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871866.1">
        <property type="nucleotide sequence ID" value="XM_007873675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWP0"/>
    <dbReference type="STRING" id="1069680.M7NWP0"/>
    <dbReference type="GeneID" id="19893713"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00015"/>
    <dbReference type="eggNOG" id="KOG0082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014184_6_0_1"/>
    <dbReference type="OMA" id="QVIWADA"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000001">
        <property type="entry name" value="Guanine nucleotide-binding protein G(I) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002307">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="150"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="175"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="200"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="269"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR11571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="353" mass="40805" checksum="6DBE099EBBBD71E7" modified="2013-05-29" version="1">MGCKISTQNSIEKQRNEEIENQLKRDKIIMRNEIKMLLLGAGESGKSTILKQMKLIHEGGYSVEEKESFKEIIYSNTIQSMRVILEAMEVMDIPLDDPKNIQYVQVILSQPNQIEGEILPQEIGEAVICLWKDAGVQQCFRRSREYQLNDSAKYYFDSIDRISRPDYLPTDQDVLRSRVKTTGITETTFIIGDVIYRMFDVGGQRSERKKWIHCFENVTTIIFLVAISEYDQLLLEDETVNRMHEALTLFDSICNSRWFIKTSIILFLNKIDIFREKLSVSPMKNYFSDYTGGDDYNAACDYILNRFVSLNQSNTKQIYTHFTCATDSSQIKFVMSAVNDIIIQTNLRGCGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWU4</accession>
    <name>M7NWU4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Upf1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PNEG_00065</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs. Also capable of unwinding double-stranded DNA and translocating on single-stranded DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871921.1">
        <property type="nucleotide sequence ID" value="XM_007873730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWU4"/>
    <dbReference type="STRING" id="1069680.M7NWU4"/>
    <dbReference type="GeneID" id="19893763"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00065"/>
    <dbReference type="eggNOG" id="KOG1802">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001666_4_0_1"/>
    <dbReference type="OMA" id="QYMQMNG"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21407">
        <property type="entry name" value="1B_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18039">
        <property type="entry name" value="DEXXQc_UPF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21400">
        <property type="entry name" value="ZBD_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000097">
        <property type="entry name" value="Regulator of nonsense transcripts 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040812">
        <property type="entry name" value="UPF1_1B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018999">
        <property type="entry name" value="UPF1_CH/ZBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF364">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18141">
        <property type="entry name" value="UPF1_1B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09416">
        <property type="entry name" value="UPF1_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51997">
        <property type="entry name" value="UPF1_CH_RICH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Upf1" evidence="17">
        <location>
            <begin position="87"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="C3H" evidence="15">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="CC/SHH/C" evidence="15">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="C4" evidence="15">
        <location>
            <begin position="155"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1008"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMR11626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1044" mass="117837" checksum="5D2392D545897776" modified="2013-05-29" version="1">MNDDFSHLDSHFYSSSDIEDTISIQSQTLTESTQAQDYEDRGESDDDYEDNYDENRSDIMSLKNLNLEDNHLDIQDTYEEPKDIELKEDLPDWACSYCGIYTPSSVLKCLTCGKWFCNSRGNTSSSHIVKHLVRARHKDVMLHHNSPLGETVLECYNCGIKNVFLLGFIPAKSDTVVVLLCRQPCASTQSSKDMNWDTSQWQPLIDDRSFLPWLVSIPTEHEVLRARQISSYQINKLEDLWKENSKATLQDLEKPGIDDEPVPVLLKYEDAYQYQNIFGPLVKIEADYDRKVKESQTQDGIVVRWDIGLNQKYLAYFKIKVLEAGDLKVAVGDEMRLRYLGELRNHWESIGYVIKIPNNISDEVGLELKKSDKIQTDCTHNFSIDYVWKSTSFDRMQMALKQLAINETSVSGYIYHKLLGHDIAPLVLKTQMPKRFSSPGLPELNVSQVHAVRSVLQKPLSLIQGPPGTGKTVTSATIVYHLAKMNPGQVLVCAPSNVAVDQLCKKIHQTGLKVVRVSAKSREDLESPVAFLTLHEQVRNNDTNTELQKLIQLRDELGELSSQDEKKYKALVKACEKEILSNADVICATCVGCGDPRLSRFKFRTVLIDEATQATEPECMIPLVMGCKQVVLVGDHQQLGPVIMNKKAAKAGLQQSLFERLVILGISPIRLTVQYRMHPCLSEFPSNMFYEGTLQNGVSKNERLRKNVDFPWPVNDTPMMFHISLGQEEISSSGTSYLNRTEASNCEKIIVKFFKAGVKFSQIGIITPYEGQRSYIVSSMQQSGSLRKDLYKEIEVASVDAFQGREKDYIIVSCVRSNEHQGIGFLSDPRRLNVALTRAKYGIVILGNPKVLCKHPLWHYLLVHYKEKNCLVEGPLNNLQVSMIHFPKPKAEYRGAQRHTMALNRPSYKSSRAPASELIPNNSSIIGNIPTHIDSYTSQNVSGFNTNYSNVFSGGSFLSGLDNWPSLSVYDKANHKVATHSQADRIIGQRLTLGQDLDSNMPYNDLDDYKTHRESYPISGTSISRGNDDDTRSLTTEYTVQIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NX02</accession>
    <name>M7NX02_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00127</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871986.1">
        <property type="nucleotide sequence ID" value="XM_007873795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NX02"/>
    <dbReference type="STRING" id="1069680.M7NX02"/>
    <dbReference type="GeneID" id="19893825"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00127"/>
    <dbReference type="eggNOG" id="KOG3745">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008002_1_0_1"/>
    <dbReference type="OMA" id="PLCKHHY"/>
    <dbReference type="OrthoDB" id="125856at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048625">
        <property type="entry name" value="Sec10_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20667">
        <property type="entry name" value="Sec10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="543"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec10 N-terminal" evidence="7">
        <location>
            <begin position="7"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec10-like alpha-helical bundle" evidence="6">
        <location>
            <begin position="131"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR11691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="767" mass="88556" checksum="10E553DF2874B709" modified="2013-05-29" version="1">MNLGFNPKPYIRVFEAALDRLVVMNSEVLSNIKENEIEAKKADIDHCSKVRKVKEKFDNIVKEFNILENEINTSGEHAIKLGKQFENINKQNSKAQEIKLLIQSYIETEKGDFNSLEKLRLKGSMESQALCASLTKNLLFLRKDINLFGSSKTIELLEKFSEILEKDLLECFDKAYKEGSLNDMAEYAKILFDFNGGGSVIRNFVNQHDFFIVPKNLQEQGINKNDEIWKELSDPDINISESDFLVKSNFQSLVDLVRKTIKTEYNIIRSVFPNPSVVFQVFLQRIFAQSIQLRLEEIIKYAELNSTLAYLRVLQATHSSLTDLVEDLKSFEQTSLSSDLSNEFSGLASYALEQCLNDLFIPYLEGSRYIEKERKSLNELYSSFLCNFNLYHAQRKSLKNSTMLDRVVSRFQAATISTQSTLTFVRDNDGNYRKSNIYRDRKERGEFSKLDEFEATENDGKCTLNCINKFLKWNAEAIGRVVELFPQSELTKDSFSVLRVLFEYVFSVYLDISLETILDTIESYDGKSEPEIKYFEELKEMTIIVNLLSTYFNIIILPIVSFSLTLKRDVIISTNSNILKIENKIDLIIQKSVDVILNWINVLLSKQKKNDFKPRDDDQRMENLSTEPCKLVVQFISKVYNIAYDNLIGLNLENFLVIFGMSFLKLLLEHFKKFFVSPSGGLILTKDLTEYEKCIGAWGIPKLNEKFKLLHELGNIFIVRSDILGSLLNQGILGRVNLKYLIPYISKRTDYYTSDINKIISNEEIHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NXA4</accession>
    <name>M7NXA4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00213</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Interacts with G-actin; ADP-actin form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872081.1">
        <property type="nucleotide sequence ID" value="XM_007873890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NXA4"/>
    <dbReference type="STRING" id="1069680.M7NXA4"/>
    <dbReference type="GeneID" id="19893911"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00213"/>
    <dbReference type="eggNOG" id="KOG1747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031995_0_0_1"/>
    <dbReference type="OMA" id="YLFKHTH"/>
    <dbReference type="OrthoDB" id="10006997at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028458">
        <property type="entry name" value="Twinfilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759:SF1">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ADF-H" evidence="8">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="ADF-H" evidence="8">
        <location>
            <begin position="134"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="287" mass="33338" checksum="F8348980B0D4A0DE" modified="2013-05-29" version="1">MYVSKSEDFYKDISSIQSILSDTKPSYILCKESFSIPEQTVIIHYVPEDAEIRDKMIYASTYHTLIQSLGSNRISRSIFISNKKELNISLFKEHLEEIKREDSLSIEEKNLQNVKNSQEYSIGCSSRQKYINDTFFLNISEEAKTAIEKLSKNTEEFNFIQLINDPQTEILNLKMTMSVKPNDIQHILPSTSPCYSIYSWSHSYNNTPAISRIFIYTCPKASTIKERMLYSSSCLMALSTIKQWIPIDKKIEAHDLIDINEAMFYSVIYPLIKKKQECFLRPKRPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M7NXD4</accession>
    <name>M7NXD4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Iron-sulfur clusters transporter ATM1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Iron-sulfur clusters transporter atm1, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PNEG_00250</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins. Hydrolyzes ATP. Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872121.1">
        <property type="nucleotide sequence ID" value="XM_007873930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NXD4"/>
    <dbReference type="STRING" id="1069680.M7NXD4"/>
    <dbReference type="GeneID" id="19893948"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00250"/>
    <dbReference type="eggNOG" id="KOG0057">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_1_1"/>
    <dbReference type="OMA" id="VFHIIPI"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140466">
        <property type="term" value="P:iron-sulfur cluster export from the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18582">
        <property type="entry name" value="ABC_6TM_ATM1_ABCB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000004">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000287">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF402">
        <property type="entry name" value="IRON-SULFUR CLUSTERS TRANSPORTER ABCB7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="19">
        <location>
            <begin position="104"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="18">
        <location>
            <begin position="426"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMR11826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="666" mass="76224" checksum="2E748FA4C235CCA4" modified="2013-05-29" version="1">MGFYNIYLPRSYGSKLFNHHQSSLKYCKYINKFTQSLYPYRPIYPLFLFHSFSKTNQLSHSKIFSDSNYSSDSDKRSSNLYIIKEISKYLWPKDDFNTKARVCLSLSLLVGSKVLNVQIPFFFKKIIDSININISTVDESTLAITGSIIIGYGLARISATAFQEIRNTIFATVSQKAIRRVAYNIFQHLLRLDLNFHLTRKTGGLTRAIDHGTKSISFLLTSMVFHILPISLEIAMVCGILTYQYGSCFGFVTLATMVFYTITTIKTTTWRTKFRKDANKADNKAATLAMESLINYETIKYFNNEQYQINLYDKCLKHYESSSIKVASSLAFLNTGQNIIFSTALTTMMYLAVKGIYTGQLSIGDLVMINQLVFQLSVPLNFLGTVYRELKQSLIDMETMFNLQKIEVTIKDHKNAKDLEFHKGEIKFENVTFGYLPERPIFENLNFTIYPGQKVAFVGPSGCGKSTILRLLFRFYDIQSGRILIDEQDIRHVTLNSLRKCIGVLPQDTPLFNDTILNNILYGRIDATMDEVIEITKATQIHSLIQKLPDKYNTKVGERGLMISGGERQRLAVSRLLLKNSPIFFFDEATSSLDNENEKSLLNNIQNILKKNNKTSIFIAHKLRTIMDSDNIIVLKNKKILESGTHDELIKKQGFYNRLWTSQETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7P2M8</accession>
    <name>M7P2M8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">STEEP1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_03578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STEEP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875671.1">
        <property type="nucleotide sequence ID" value="XM_007877480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P2M8"/>
    <dbReference type="STRING" id="1069680.M7P2M8"/>
    <dbReference type="GeneID" id="19897265"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03578"/>
    <dbReference type="eggNOG" id="KOG4397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2110391_0_0_1"/>
    <dbReference type="OMA" id="CELWLAY"/>
    <dbReference type="OrthoDB" id="418131at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090158">
        <property type="term" value="P:endoplasmic reticulum membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029704">
        <property type="entry name" value="STEEP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057965">
        <property type="entry name" value="STEEP1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46355:SF1">
        <property type="entry name" value="STING ER EXIT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46355">
        <property type="entry name" value="UPF0428 PROTEIN CXORF56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25809">
        <property type="entry name" value="STEEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STEEP1" evidence="2">
        <location>
            <begin position="7"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="111" mass="13173" checksum="5A142F42500B78CD" modified="2013-05-29" version="1">MKEVSLKDFNSYFCICGEYSLSISTDLKNLPKRQYDNALIVNKTKHTFRITFIKQPEPLILERENGYEKRWMYTCRRCELWLAYELQGVETAKNYLYIISKALISEPFAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M7P382</accession>
    <name>M7P382_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_03435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875522.1">
        <property type="nucleotide sequence ID" value="XM_007877331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P382"/>
    <dbReference type="STRING" id="1069680.M7P382"/>
    <dbReference type="GeneID" id="19897122"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03435"/>
    <dbReference type="HOGENOM" id="CLU_022141_0_0_1"/>
    <dbReference type="OrthoDB" id="5464814at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052690">
        <property type="entry name" value="Antho-RFamide"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31709">
        <property type="entry name" value="LEUCINE ZIPPER PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31709:SF3">
        <property type="entry name" value="LEUCINE ZIPPER PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082732" evidence="2">
        <location>
            <begin position="18"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="742" mass="83782" checksum="8ABC18035155B646" modified="2013-05-29" version="1">MKIILFFLFTFITYVLSGTFGFAALMPPYNLSNPELEFKKDLVSGAYSFDELLIFLTNGNTHSCSEHLSNACKELTRVYGDLSRVGDAVKSICEHQHEACQKLPEVKKELCETEDVTYTDGLEKTSPLDSYQCLYSYTKCRLRSRGCSYEYMKECRTLLYACQRSYNEYKLYTLFTNLISDDYYSESFQEKLKVLCRDLFNTSDLLVQLCLNPDLLVSELGKFDFLRKEGRGGFFLYPKMSAGALLDTQKLDGGLFLPRTDPSVNPAYFMGYLLGQQGFTKIMFDCMKIGHKCLGLGFFPQSAYFCDARSDAHWDVPCLKASLLLLDEEVPNLENKLHREIWKERYPESVFWTGINVDLCTQLLRPCSYLKRLDPKLFRLCTLLEGHCAHGLEVGSSLSVFERYLRGINSGHDSNSRFDLCQKEIPQVCTSILNTTVDFLTFCLRPLHTCLALEELVQLRCTEIKKEMTDTDPTEQQCTDQLLGASVYRVQCPLSEEYLKFLTTCYTSYPKNQYLKELAGSILKDLTSQEDKSRKLNDGSGKPNDEVFGKPNDEVFGKPNDEVSGKPNDEESGKPNDEVFGKPNDEVSGKPNDEVFGRPNDEVFGKPNDEVSGKPNDEVSGKPNDEESGKPNDEVFGKPNDEVFGKPNDEVFGKPNDEVSGKPNDEESGKPNDEVFGKPNDEVFGRPNDEVFGKPNDEVFGKPNDEVFGKPNDEVFGKPNDEVFGKPNDEESGKPNDDDGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3Q9</accession>
    <name>M7P3Q9_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_03321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875397.1">
        <property type="nucleotide sequence ID" value="XM_007877206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P3Q9"/>
    <dbReference type="GeneID" id="19897008"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03321"/>
    <dbReference type="HOGENOM" id="CLU_2387093_0_0_1"/>
    <dbReference type="OrthoDB" id="5399555at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="94" mass="10959" checksum="6F913D55782DCCB6" modified="2013-05-29" version="1">MSSLIKSHISQELLVHSEISSLASTSSKDQFLQKVEELLFLNAAHMECQRFKLSESKSNEMYELSFRARLERAEKRRYVGQDAESKCKKYNKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M7P417</accession>
    <name>M7P417_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_03086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875142.1">
        <property type="nucleotide sequence ID" value="XM_007876951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P417"/>
    <dbReference type="GeneID" id="19896773"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03086"/>
    <dbReference type="HOGENOM" id="CLU_2292881_0_0_1"/>
    <dbReference type="OrthoDB" id="5336357at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="101" mass="11805" checksum="C8053EAE39FDA3F6" modified="2013-05-29" version="1">MNKKRNYNDLLICNRLKKKYKDNFPSLEEIYTSTLAKLYSAQNTVINHLIEEKKPDIQPLQCDDCDQVIIPTSDILLNLNDYSCIACHHIVCDICRVIQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7P489</accession>
    <name>M7P489_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha-MPP</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Inactive zinc metalloprotease alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_02847</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874885.1">
        <property type="nucleotide sequence ID" value="XM_007876694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P489"/>
    <dbReference type="STRING" id="1069680.M7P489"/>
    <dbReference type="GeneID" id="19896534"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02847"/>
    <dbReference type="eggNOG" id="KOG2067">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_5_2_1"/>
    <dbReference type="OMA" id="LKYHHSP"/>
    <dbReference type="OrthoDB" id="277191at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017087">
        <property type="term" value="C:mitochondrial processing peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000023">
        <property type="entry name" value="Mitochondrial processing peptidase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF49">
        <property type="entry name" value="MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="9">
        <location>
            <begin position="105"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="408" mass="45776" checksum="652143934520B141" modified="2013-05-29" version="1">MINSLESLGGNFMCSSSRESLMYQTAVFNNDVENMIKLLSETILDPIITKEDLEEQKLAIQYEINEITSKPELILPEMLHITAYKNNTLGNPLLCPEERLPFISLSTISKYRSLFYRPERMVVAFVGVEHSKARDLAEKYFGNFKNNEMSFNPFTLQDKSLKLPFQEKQFPEEIFLPAHYTGGIMNIPLSKPNQEFTHIYIAFEGIPLSDPDIYALATLQILLGGGGSFSAGGPGKGMYSRLFLNILNQYGWIESCASFNHSYTDSGIFGISASCRHDSVHALINVICQELTFTMQKGRKGINKIEVERAKNQLRSSLMMNLESKMIILEDLGRQAQTMNEKKITAQEMCDKISSLTVNDLQKIAEKVFTGLVKNKGQGTGQPTIVTQGKTEKVSNASDIIKRYGLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7P509</accession>
    <name>M7P509_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Replication factor C subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02716</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874741.1">
        <property type="nucleotide sequence ID" value="XM_007876550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P509"/>
    <dbReference type="STRING" id="1069680.M7P509"/>
    <dbReference type="GeneID" id="19896407"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02716"/>
    <dbReference type="eggNOG" id="KOG2035">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042324_5_0_1"/>
    <dbReference type="OMA" id="LKADIMH"/>
    <dbReference type="OrthoDB" id="761538at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000030">
        <property type="entry name" value="replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000002">
        <property type="entry name" value="Replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000136">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF1">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13177">
        <property type="entry name" value="DNA_pol3_delta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22534">
        <property type="entry name" value="RFC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="34"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="351" mass="40505" checksum="30B864D815078681" modified="2013-05-29" version="1">MALFIDKYRPKLLDHMHFHEKLTKTLKALAKSSDFPHLLVYGPHGSGKKTRVLATLREIYGSGIEKLKLDQKMILTPSNKKVKINIISSNYHLEFTPSDTGIYDRIVIQDLLKEIAQTRQVDISAKQRFKVVIINEADHLTSEAQAALRRTMEKYYPNLRLILITNSTSKIMAPIQSRCFLVRVSAPKLEDVIIVLKYIASKEHFSIPDLLCNKIASDCKRNLRRALLMLEAVYAKNSYLTEDLTIPMPDWEIYISQIADSIIQEQTPSRILQVRGKLYELITHCIPPSLILEVLTFNLISKIDDALKPETIEWATFYEHRLQLGNKAIFHLEAFVSKFMRIHSSYYNDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7P571</accession>
    <name>M7P571_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02798</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874831.1">
        <property type="nucleotide sequence ID" value="XM_007876640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P571"/>
    <dbReference type="STRING" id="1069680.M7P571"/>
    <dbReference type="GeneID" id="19896487"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02798"/>
    <dbReference type="eggNOG" id="KOG2848">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1378654_0_0_1"/>
    <dbReference type="OrthoDB" id="202234at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="4">
        <location>
            <begin position="82"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="198" mass="23199" checksum="5FB530FA111F7DD4" modified="2013-05-29" version="1">MAILFFKSILYHTRFWAKLLLYYWTLFISAFSGVVLSIILFVLGKSNISQWGVARICNTISAPALNLKIHVENEHFMRVRPCVFISNHQSELDILLLGRLFPKYCSIVSKKSLKYVPFLGWFMILSKTIFIDRAKRENSIKIFEEVSGQIKANKVNVRHWLIIIKLSIKSKVYGFLLRERDQDLKVLIFCRLKKGHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6D1</accession>
    <name>M7P6D1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">Acylphosphatase</fullName>
            <ecNumber evidence="2 5 6">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02368</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 5 6">
            <text>an acyl phosphate + H2O = a carboxylate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the acylphosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="2 5 6"/>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874373.1">
        <property type="nucleotide sequence ID" value="XM_007876182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P6D1"/>
    <dbReference type="STRING" id="1069680.M7P6D1"/>
    <dbReference type="GeneID" id="19896061"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02368"/>
    <dbReference type="eggNOG" id="KOG3360">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141932_3_2_1"/>
    <dbReference type="OMA" id="WVRNTSH"/>
    <dbReference type="OrthoDB" id="7961613at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10029">
        <property type="entry name" value="ACYLPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10029:SF3">
        <property type="entry name" value="ACYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00112">
        <property type="entry name" value="ACYLPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="Acylphosphatase/BLUF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00151">
        <property type="entry name" value="ACYLPHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="8">
        <location>
            <begin position="5"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="96" mass="11065" checksum="8C8794A0D139D027" modified="2013-05-29" version="1">MTKKRVYFEVFGKVQGVYFRNYIVEKAKSLSIVGWCRNTANGSVEIEAEGTEQDLDVFKKWLQYEGSPLSRVDNIIAKEISVINNEESMVRLKTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6G5</accession>
    <name>M7P6G5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_02407</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 81 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874413.1">
        <property type="nucleotide sequence ID" value="XM_007876222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P6G5"/>
    <dbReference type="STRING" id="1069680.M7P6G5"/>
    <dbReference type="GeneID" id="19896100"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02407"/>
    <dbReference type="eggNOG" id="KOG2254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005482_2_1_1"/>
    <dbReference type="OMA" id="DTMFAYA"/>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072324">
        <property type="term" value="C:ascus epiplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990819">
        <property type="term" value="C:mating projection actin fusion focus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071998">
        <property type="term" value="P:ascospore release from ascus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042815">
        <property type="term" value="P:bipolar cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904541">
        <property type="term" value="P:fungal-type cell wall disassembly involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097248">
        <property type="term" value="P:maintenance of protein location in cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1170">
        <property type="entry name" value="glycoside hydrolase family 81 endo-[beta] glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005200">
        <property type="entry name" value="Endo-beta-glucanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040720">
        <property type="entry name" value="GH81_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040451">
        <property type="entry name" value="GH81_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983">
        <property type="entry name" value="ENDO-1,3(4)-BETA-GLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983:SF0">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-D-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17652">
        <property type="entry name" value="Glyco_hydro81C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03639">
        <property type="entry name" value="Glyco_hydro_81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52008">
        <property type="entry name" value="GH81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 81 N-terminal" evidence="10">
        <location>
            <begin position="120"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 81 C-terminal" evidence="11">
        <location>
            <begin position="431"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR09465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="786" mass="89873" checksum="8D5A94ADAF446647" modified="2013-05-29" version="1">MKLPYTFFIHQNHLHLCIIMVFFISYIWSIPIMGYPNLSLSNTRTPRFSGIPSLGFMSRIFDFLKGIIKYFGKGYNKDDTNTTSSNTTKIDVLTPITTREPLSLFKSMNSTLSPLSIHENDLKKPIHTNKFYSNFYLGTQRFPSFLDPYVLTWNYGVYSGIAVAHSDDNQKVFGEGTPPKYFFNPLGVYSATFTAKELENASLTLTSLDQMSVNVIVNPSNCTEKKIEMPLVRGMAYVTGIYTDLTPIFTSVVGFRNIEKKQIDDYYKFKATLHDGKKWLLYVFPKEKSEFNFEIEGVTLKATNGTFNGFIQLAKIPIDNDDAESILDASAGTYATKILLSASVSGNTGSYTFRFETHDYKNNSLLHFAMPHHIVSFDSDTASRKTNLSLPSPTNGLMVAYTGKYWNMLENDLPVNINFFPYSPSAKKPSYSKEALEMIRKAAIDEIAQDFCLQIDPNSYYFSGKVLSKFALLCFSIKNILKNDTLAEECLTKLKDCFMPFVKNSRTYKLVYEKTWFGIVTEQGFVKDKLSDFGASFYNDHHFHYGYLIFTAAIIGYLDKKWIEENKDWVIDLIRDVANPVNDSYFPAFRYFDWFAGHSWSKGLFESGDGKDEESSSEDYNFYFAVKLFGHSINDTVIISRSNLMLAVMKRSLLTYFLYEPSNTVMPKAFLSNYVAGIKFMNKIDHSTYFSPRPECIQGIHMLPLTPISPYIRIPSFVRSEWDNKLASIVDTIEDGWKSILYANLAIIDPKKSYEFFSMNFDKKFLDIGSSLTWYLVYSSAFANSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M7P7L8</accession>
    <name>M7P7L8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dynamin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_02031</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874011.1">
        <property type="nucleotide sequence ID" value="XM_007875820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P7L8"/>
    <dbReference type="STRING" id="1069680.M7P7L8"/>
    <dbReference type="GeneID" id="19895725"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02031"/>
    <dbReference type="eggNOG" id="KOG0448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011752_0_0_1"/>
    <dbReference type="OMA" id="RCERMIL"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990626">
        <property type="term" value="P:mitochondrial outer membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051646">
        <property type="term" value="P:mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000638">
        <property type="entry name" value="Transmembrane GTPase Fzo1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465:SF0">
        <property type="entry name" value="SARCALUMENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="662"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="Dynamin-type G" evidence="13">
        <location>
            <begin position="188"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR09850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="789" mass="92121" checksum="1EA4593A01015627" modified="2013-05-29" version="1">MDLEIYSSNILSELFLKKSPDYFQEHYQQLLYNNSKLQLLQYAERTKKLLSDLIKFNNKKEWVIHYPSLNKNDKFHETIQKNSKGNETEKKKKFSLERTDCKHIHFTNSLTLKNTSNNSNVIIENIEQKRHKFKTFFSKLNILKLQLKLGEITAVELTQLEKSTIALLLNKKIFENIKHIEVLMERIKNKSSKILVTGDLNSGKSTFCNALLRQKILPEDQQPCTEVFCEIIDSYKNSGKEEVHAIPHGMIYDKQNSNTYTILKIHDLNKIVIDSKTWSYIKIYINNVHTKNQNILRNDTLDITLIDSPGLNFSSMITTAVFSKQEEIDIIIFVVNAKNHFTLSAKEFILNASNEKALLFIVVNKFDSVKDKERCKDVILNQIFNLSPQTYYNASELVHFVNSASVTENNKTFNNSDFEKLEKDLKIFILEKRIKSKLSPGKTYLLNLLTDIKILCETNKYEAIFQIQNLKKELKLITPICKQITEEKKKILNEVKKIIENVCLSASKYSYEHLSTAIMKMEYIQPCNYQGFLKAYSYAMNTKRNMLNYIELCLNDTETFARMKTNRGIDEINNLRIIHIKPFKKIFQPQYMFSKHKNIIKKSAYVDIDLFDFIDFNQKNHTFIAIMGTCSILCGKIAGYHNIITTIFNTFNIIGTKNLKKLIIPFICLAVLSTCSYAILNIPKVIPKKIAKKIRQKLENSDFINQNSLRIISECQKVLKYPQKDLHLLFQKTIKKHYSRKEEILKNWKISKHANIFFSELSLQAEQKCKELNNINIDNYIPNNNNNKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7P8H4</accession>
    <name>M7P8H4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873384.1">
        <property type="nucleotide sequence ID" value="XM_007875193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P8H4"/>
    <dbReference type="STRING" id="1069680.M7P8H4"/>
    <dbReference type="GeneID" id="19895141"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01444"/>
    <dbReference type="eggNOG" id="KOG4400">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058879_0_2_1"/>
    <dbReference type="OMA" id="EHKQCYN"/>
    <dbReference type="OrthoDB" id="3863715at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000016">
        <property type="entry name" value="Cellular nucleic acid-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000085">
        <property type="entry name" value="Zinc knuckle nucleic acid binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051714">
        <property type="entry name" value="Znf_CCHC_NABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23002">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="194" mass="21296" checksum="36D512842D84968B" modified="2013-05-29" version="1">MIRRSCYKCGDLGHFADSCAKTDRLCYNCKQPGHESNACPFPRTTERMQCYYCQSIGHIQADCPSFRLNPIGSGGRCYICGIIGHLARDCHGISTFSSVHFVSTRSQVCFKCGGPNHFARDCQALSVKCYACGKYGHISSICENASQTSKSCYRCGNLEHLAKDCTIITTNNDQDSNDNISSTNNPVSQTTLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7P8K8</accession>
    <name>M7P8K8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01468</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SGT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873407.1">
        <property type="nucleotide sequence ID" value="XM_007875216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P8K8"/>
    <dbReference type="STRING" id="1069680.M7P8K8"/>
    <dbReference type="GeneID" id="19895164"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01468"/>
    <dbReference type="eggNOG" id="KOG1309">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039532_3_1_1"/>
    <dbReference type="OMA" id="WIKKCEE"/>
    <dbReference type="OrthoDB" id="1898560at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06466">
        <property type="entry name" value="p23_CS_SGT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044563">
        <property type="entry name" value="Sgt1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45862">
        <property type="entry name" value="PROTEIN SGT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05002">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="4"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="4">
        <location>
            <begin position="177"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="SGS" evidence="3">
        <location>
            <begin position="286"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR10195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="43296" checksum="2FE8972DD74481BC" modified="2013-05-29" version="1">MSPAADLAKQAEKYTELKEYSNAIEALTRALKEIPTSIDYHIKRSTAHHCNKQYKEALKDAEAAVYLAHLKGKREQKGLAQLRRGITLFQLGQLGNSYFALKKAEEAIPDNNMLASWLLKAKIALENVEGEKECTILEKPDLKDLDHFLQTEIKKIEVVELPVETNIQKMSLHEKEKQTIRHEWYQNDDTVTIILYAKSVDKNTLKKEFKEKSLSVSFFLPVTQENYTFELHHLFSEIDVLSSTFRIYNTKIEIKLKKRYPEKWLTLETEISNIQTIDKNSSKFNIYPSSSKYGSKDWDLLSRTMITEKEETGDAALNKLFQEIYANADDDTKRAMMKSYIESNGTALSTNWKEVGAKRVEVQPPSGMEVKPWYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7P959</accession>
    <name>M7P959_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_01632</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873589.1">
        <property type="nucleotide sequence ID" value="XM_007875398.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P959"/>
    <dbReference type="STRING" id="1069680.M7P959"/>
    <dbReference type="GeneID" id="19895326"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01632"/>
    <dbReference type="eggNOG" id="KOG1315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027721_1_1_1"/>
    <dbReference type="OMA" id="NCYSSFP"/>
    <dbReference type="OrthoDB" id="302728at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="101"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR10380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="304" mass="35459" checksum="9FFE572F349563D1" modified="2013-05-29" version="1">MLSFHVKLKPYLHKLTTYIPRAIVYCLLLWSFWVYTWTICIKTVSNFYGIILIFFASIGFIISFWCYTATTFTFPGSPRGNDGYVCIESRNYSTFISVKQNGSARFCNKCEILKPDRTHHCSICNYCILKMDHHCPWLSNCIGFANYKQFLLFLIYISIYSIYLFISSLIILYKFIILLNIPSKNVIPVNWMLLLVISGVFSIVLGIFTIWHIFLVSRNLTTIEALKQTCYIGNLNNDDSRSNSKIRNAFDLGWKKNWIQVMGSNKFLWFFPIVNNLGTGESFPVNNDIAKKLYEYFHHSKNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M7P9K8</accession>
    <name>M7P9K8_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873184.1">
        <property type="nucleotide sequence ID" value="XM_007874993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P9K8"/>
    <dbReference type="GeneID" id="19894958"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01261"/>
    <dbReference type="HOGENOM" id="CLU_3069722_0_0_1"/>
    <dbReference type="OrthoDB" id="5406176at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="53" mass="5973" checksum="E3B2259A79DDBA41" modified="2013-05-29" version="1">MSFFFVRQPPITQIPEVLFSGTKELPAIVVSPATSRDSTSLIKSKSKFLNFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7P9P8</accession>
    <name>M7P9P8_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">E3 ubiquitin-protein ligase RBX1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_01300</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873225.1">
        <property type="nucleotide sequence ID" value="XM_007875034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P9P8"/>
    <dbReference type="STRING" id="1069680.M7P9P8"/>
    <dbReference type="GeneID" id="19894997"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01300"/>
    <dbReference type="eggNOG" id="KOG2930">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148178_0_0_1"/>
    <dbReference type="OMA" id="DTCVECQ"/>
    <dbReference type="OrthoDB" id="8962942at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043494">
        <property type="term" value="C:CLRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043224">
        <property type="term" value="C:nuclear SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140851">
        <property type="term" value="F:histone H3K14 ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16485">
        <property type="entry name" value="mRING-H2-C3H2C2D_RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000010">
        <property type="entry name" value="E3 ubiquitin-protein ligase RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="92"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR10595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="147" mass="16907" checksum="5DE8D0EA2BEC529C" modified="2013-05-29" version="1">MEYSLSESQSMVEDSMEFRTEGNVLEEFGTLPTTSTSIPTEIIEDEKPLGPSVSGTLKPRFEVKKWNAVALWAWDIIVDNCAICRNHIMDFCIECQANQVAPISEACTVAWGICNHAFHFHCISRWLKTRQVCPLDNREWEYQKYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7PB31</accession>
    <name>M7PB31_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SMP-LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_00689</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872587.1">
        <property type="nucleotide sequence ID" value="XM_007874396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PB31"/>
    <dbReference type="STRING" id="1069680.M7PB31"/>
    <dbReference type="GeneID" id="19894387"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00689"/>
    <dbReference type="eggNOG" id="KOG2238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_298448_0_0_1"/>
    <dbReference type="OrthoDB" id="26740at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21675">
        <property type="entry name" value="SMP_TEX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019411">
        <property type="entry name" value="MMM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF19">
        <property type="entry name" value="NUCLEUS-VACUOLE JUNCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10296">
        <property type="entry name" value="MMM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15413">
        <property type="entry name" value="PH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="287"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="737"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="916"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="737"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="918"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR11090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1007" mass="114250" checksum="DCE79CABB736F47C" modified="2013-05-29" version="1">MCPLHEHQLHKMDFSIMTLKTYTFVYIFGGITFIPLVFVIFFVYSWIVLPDVDQTVFKSFKKYSFLNKKNRLKTLDSLDEATGVYKTGWIRVTREVDEMDIENIENKMSGTEGGTGNNIAGQTPGNNMSGGILNTTNVKKQRKGPALFFAVLKHGNLFLYDKENRSDVKYVIVLAQYHVSIYPKGSKDGELFTRTHAICLSREKNEQKKLKKDTESILDETRPRNKFLIYNSNPSDQEDWYFLLIQASKTLDKKCEWKENPCVSAVPLIFHSKHMSKLIHAIHSTDAQLETRWLNALLGRLFLGLYRTRFSQEYIIEKIRKKVSRIKKPGFLSDIVVKGVDIGDSIPYITCPRLRDLSSDGQLNIDAMITYNGNFRIEIATTATLNLGSRFKARQVELMLAVILKKFEGTLALIIKPPPSNRLWYGFYEMPKIDMTIEPIVFSKQITYSMILKVIENRIRETIHNTLVFPYMEDFEFYDTTDQFFRGGIWDHSKMQEKESESEKEISVIEKQESNEETLLDVLDDIKEKSNLSKMVSTNSENEAPNKSKHSILLTTLRSSGSEVKKNPLKRSSSYNTISDNSSLVDLENRSSTEIPSGDKSFKDLCGKSFVTAAAISAFGKSTVLPKTFNKISHFKTPKSEDISKLDIELDKKAIDVENESITSSTSTNSFKSSFTTKKERLSAAFATMRENTIFDNKRKSESGEKSSLSSSVSSATNTVRRWGANYIAKRHGNTSIDSESLNYTSSHTSPLSFQVNKKKTSSSNLNENPPDYSEISTDSIVYDSLQLSEPSCATTTDTVHAFSNKHISIPEPLESMTEQSYTISKPFSQRTDLDYDTLLPKQRPIPPILPMRRDLPSPPALPARRNVVKQIIIPEPSKTLDNANSHKTNVDSDDRVVDCDDKNVDHDIIAENLFQDSSEKNDESKNNNELENSIEQKSSFELDNIIELENTIELDNITEPEDTTQLADTSKLDGIAESENSMELEDMVELEDIINSKSIKRSTNTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7PBN4</accession>
    <name>M7PBN4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase delta subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872172.1">
        <property type="nucleotide sequence ID" value="XM_007873981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PBN4"/>
    <dbReference type="STRING" id="1069680.M7PBN4"/>
    <dbReference type="GeneID" id="19893998"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00300"/>
    <dbReference type="eggNOG" id="ENOG502SC9I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1907565_0_0_1"/>
    <dbReference type="OMA" id="YVNIDEQ"/>
    <dbReference type="OrthoDB" id="337486at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007218">
        <property type="entry name" value="DNA_pol_delta_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04081">
        <property type="entry name" value="DNA_pol_delta_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="15397" checksum="BFACBAFAAD28AE3A" modified="2013-05-29" version="1">MPSLKTGKKLKPLQRKLVDSFPSLKVSKVSSKQLKKTDDNIVQKKNILKSEIQTNEKVINLYRSEEDFFPSVVEKSNYVNIDEQTHIDEALNMFDLTYKYGPFVGLSRLDRWNRAEKLGLCPPIEIKKLLLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7PBU4</accession>
    <name>M7PBU4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA-binding protein RAP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00369</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of telomere length, clustering and has a specific role in telomere position effect (TPE).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Chromosome</location>
            <location evidence="5">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872242.1">
        <property type="nucleotide sequence ID" value="XM_007874051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PBU4"/>
    <dbReference type="STRING" id="1069680.M7PBU4"/>
    <dbReference type="GeneID" id="19894067"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00369"/>
    <dbReference type="HOGENOM" id="CLU_415109_0_0_1"/>
    <dbReference type="OrthoDB" id="435460at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070187">
        <property type="term" value="C:shelterin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031848">
        <property type="term" value="P:protection from non-homologous end joining at telomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021661">
        <property type="entry name" value="Rap1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038104">
        <property type="entry name" value="Rap1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039595">
        <property type="entry name" value="TE2IP/Rap1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466">
        <property type="entry name" value="TELOMERE REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466:SF6">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11626">
        <property type="entry name" value="Rap1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0779">Telomere</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BRCT" evidence="6">
        <location>
            <begin position="11"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="661" mass="77401" checksum="F8987C33535624A0" modified="2013-05-29" version="1">MPNIFKNTDGTNMEFFLTHTIAERVSLRNSIEEYGGKTSIINDNKNKDLIILGDPLKDYKTPDIVSYYFILDSINLGKLLNIKEYYVNLSSEMRMNNLKKKRYKNFSKNEDILIDIMRYLQIFKNGIEIHDEISKKYEKHLFYTLDDYQFVFEPKFEPILLAKLDFNNNFTLSKYIEQSFLKNDCILIDFPKNLNLLYKDELVYKKLDNLYLHQNYISLRNPHANILLSLFDTGYNFNYNLKNENILNNISFRKSKNYIYDISKESFKSINKLSFFMSNPLIQKSDGYNTIYNFGDRIKKSYEILQIQIYKANEVILNNNESVPKYDFSRDDLKKNNSSDTDIHYILKNISKIKCYDSLDNSLFFPDTLVNKRTNSPEIYVSSKRRKLLRGFTCNNSKNDDLILNRNITLHEIKQKDLNIRQSKDLKEINKQGYLVPVNTDKIQNASTTMITSNAYSQSQINNYLQMPVPLLSLKKSVLNLNKENDAKTSVSSNVISDGNLSIHNQKISQISKFNSQESLPNSPILSNNINQTEFQKDLDSNNQNVNFYGRNLNDHNPISIETTYVLRKTVDWYLRNMKKYNITQQDVTLALYRTSGIKKLAIIVMDAMSKNLPLPNIKGIWTEEDDIIVYCGNSKELKQLNKKHGGKLHNRIRFLQDYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>M7PC09</accession>
    <name>M7PC09_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_00443</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872321.1">
        <property type="nucleotide sequence ID" value="XM_007874130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PC09"/>
    <dbReference type="STRING" id="1069680.M7PC09"/>
    <dbReference type="GeneID" id="19894141"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00443"/>
    <dbReference type="eggNOG" id="KOG0389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_16_2_1"/>
    <dbReference type="OMA" id="MMLDVVE"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000706">
        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033120">
        <property type="term" value="P:positive regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17998">
        <property type="entry name" value="DEXHc_SMARCAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000014">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="471"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="828"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR11420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1003" mass="115772" checksum="5C2D4D139E7306BD" modified="2013-05-29" version="1">MTVFKNKKRCIDLTEEAEEPLDREEKEVIQVLCSSPISISSFLNENQTRNKNIDILSSNIEESKDLIQKTNLIPKKNKNEYGVVNVVEPSYSLSFENNFSTIYQEKAEDTTFIVKESPIGRFKEYASQFAYQPKGNTNIEANEMIQRSDVDGYANSLSNKYLIQKTAQTRDDTEKKLDNDMFLKKKDFLRRIYPHLPEYVLENMILKPSPDFNNMTELVNLENVDITNLRSSPIGIQEKITSKRTLQHSRYTIREKHINSTQNQNYITHVHGTDKFVQKKRLVRGISRTKNQKDSFSESDDSSISNEGINDNNQLEEETLKFLNQKSAKEIADLANCTLEIAEEIIQSRPFKDIDSIKEIRSKCKTDEKDRRKEKKTLGMKVLESCMEMLEGYKAIDSLISKCDELGKSISKSISNWGIKIAPETGELSIGSDDIDKIQINDQEYINQQPNLIPDTVKLKRYQLFGVNWLNLLYRKKLSGILADEMGLGKTCQIIAFFAHLLELGKSGPHLIVVPASTLENWLRELAKFCPALKVEPYYGTQNERLDIRYHLEENPDYNIIITTYQLATGSKEDRTFLRRQRFDVCVYDEGHFLKNSLSERYKHLMNINANFRLLLTGTPLQNNLKELISLLFFILPTLFSENIEKLITVFKIKTINDGNSGSALLSEQRIMRAKSMMTPFVLRRKKIHVLNDLPKKIQHIEFCEMNKEQQNIYDECIFTQKKSIEAKTSGVESKNDKKRTFNILMQLRKATNHPLLFRRIYNNVILKKIAKNIMKEPDYQNANQNYIYEDMEVMTDFEIHQLCKKFPSIQSFALKGTPWMNAGKVEKLKYLLIEAKERGNKVLLFSQFVETLNILEEVLETLNIAFTRLDGRTSVDTRQDIIDQFTDESDITVFLLSTKAGGFGINLSCANVVILYDGSFNPHDDKQAEDRAHRVGQTKEVHVIRLVTKNTIEEYIQSLANTKLALDSSISGLDDEQLELKAEIYVKNLIENPSYQNFTLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCC1</accession>
    <name>M7PCC1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major surface glycoprotein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_00563</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11555.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872456.2">
        <property type="nucleotide sequence ID" value="XM_007874265.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCC1"/>
    <dbReference type="STRING" id="1069680.M7PCC1"/>
    <dbReference type="GeneID" id="19894261"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00563"/>
    <dbReference type="eggNOG" id="KOG3544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010455_0_0_1"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021041">
        <property type="entry name" value="Maj_surf_glycoprot_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003330">
        <property type="entry name" value="MSG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02349">
        <property type="entry name" value="MSG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12373">
        <property type="entry name" value="Msg2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006963420" description="Major surface glycoprotein 2 C-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="domain" description="Major surface glycoprotein 2 C-terminal" evidence="4">
        <location>
            <begin position="870"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="812"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1029"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="578"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="764"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="836"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="846"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1036"/>
            <end position="1056"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR11555.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1079" mass="123247" checksum="B6D3DC93A4AD6764" modified="2016-03-16" version="2">MINKIILIAILNLIALTYGNQSVDLSIRNSQTNALNPSFKSFIEEDIYGFILKENYDDENKCKAKLEEYCKELKDIDPELNKVNSNVKEICNNNNKEQKCKDLKLNIKENLDKISNELYVILQKSLTYEDFDKYLPRCLFLHNLTKNILEYCYLLKYNYYIRKHLKLTLELILHAVGNSIANYDDFKEKMKEICPILIQQGTNFISECFKIKESFEELNKYINYFCNSLNINLNDNELQEQCHKKLKSCYFLKNKCKKKCNELKVLCEKKNITYKPPGKDFNPIEPETTLLKIELEDFYKKMKDEGIYIGNVEATLDNILIYLSSTTTGFSGNKCRIVLSGNCDFFKFLSPEFKELCQNSRRQKCRDISKITNKCRKFKIMLYLAGFSTHFQDHIIGQDILWDKLSTSFSDKELLKFDTNCFYIQRSCRNNLLEVCKNVKIANNKKQQRQLFIKLIEGKLVEEQYNLKSKDDKLKICQKVVMEKCVTLVNSNIENFLKCLRPKEICLELEEIIFTRSKDLEQALDQARDFPKEEDCVELKKGCESIAGDLGSNNAKCVTLKERCKYLKVTKELKYVFLKDKSDSLANIQNCMKALKEKCDRLFKRGTNTFDISCALPEETCKFMVSEVKNHCSTFKNNIEKHDIVNKSKNGNETLVEEICILWDPYCDELMENCPDKLKKGDNGNEKGVCLQLKENCRPFFEKLKLENELMHELKGSLGDKTKCKKTLGKHCTEKKNQANQKFNSFCNTDKNKNVEEKVCKKLVEKIKRKCPTLENELNEEKDELKKKKDEYEKVKQESEKFAKEAKLLLSIPEQDGQGGGSKVQDGNAPKSVGPPVQPPAPAQPTPGGAPAAPAAPGGSTPSGTTNTSNVILVRRTFVSGEVSEPEKKAFVATARTLELYLELKEKCKGLKGDCGFRKDCPGCEAACTEIDKLCEGIKGLKVTPHHTVTLMTIQITTTTMITTTTTTTITTTTTATKSIHGGKVTEQCAFSQTTEIWLLRTCLHTSTLTSTSTVTSTVTLTSMRKCKPTRCTSDSSKETETQKEEEKEEKAKQNEGMKMRVPEIVKIILLGVMVIGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCD4</accession>
    <name>M7PCD4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="14">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PNEG_03572</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="14"/>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875665.1">
        <property type="nucleotide sequence ID" value="XM_007877474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCD4"/>
    <dbReference type="STRING" id="1069680.M7PCD4"/>
    <dbReference type="GeneID" id="19897259"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03572"/>
    <dbReference type="eggNOG" id="KOG2124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007676_0_0_1"/>
    <dbReference type="OMA" id="QSYFHRE"/>
    <dbReference type="OrthoDB" id="2748310at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000015">
        <property type="entry name" value="GPI ethanolamine phosphate transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
        <property type="entry name" value="PigN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 14" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="449"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="511"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="550"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="603"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="628"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="664"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="699"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="723"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="795"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="836"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="868"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="893"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 1 C-terminal" evidence="15">
        <location>
            <begin position="438"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMR08134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="935" mass="107926" checksum="4C1197597578FE50" modified="2013-05-29" version="1">MPRFSRRSILIIGILFHVIYLRSIFDIYFTSPLVHGMQQFKVENHIPAKRLFLIVGDGLRADKLFESYLNPETNIYETYAPFLQSIVLNKGCFGISHTRVPTESRPGHVAIIAGFYEDVSAVTKGWKTNPVNFDSVFNQSQHTWSFGSPDILPMFAYGASDISRVETFMYEKEMEDFSKDSTILDTWVFDKVIELFENATSNSAIKEALSQDKIIFFLHLLGLDTTGHSYRPYSKEYLNNIKVVDSGVKKIVEFIENYYNDGKTAWIFTSDHGMSDLGTHGDGHPDNTRTPLIAWGSGINPPDKLNVSGHDEFSKNWIISSVKRMDVLQADIAPLMAYLVGLNFPMNSVGQLPLDYLSCSLDIKSQVAFTNALEVAEQYKIKHEYKSLTKIAFKPFKHLNNKTHNLDTYKNHIKTLIDDHKYNEAIKICKEMIKICLEGLQYLQTYDSLFLRSIITLGYLGWIVFMFIQLINIYIPKDTYQPKRTIFSSLFFSFILIGLFIILYIEKSPLFYYAYIIFPIFFWEHIFTNRKNIYKCYVLFFKNIKKTYKNTIFFVKSMLYITLLETIVIGYSQRKVFTAYFILVSFWPLTHGIKFIRDNKILISLWMLNSFITSTFTLFDTVKKERLSLILIGGFIMFLFGTIYLIFGDLLLKKYKTMVKMPQTIISLQLGLLILSIVVTHLSVLSLQAKKGLPFGNQVVGWLVLVFSLIIPFITLMKKKNYYIHNLVIIFLMFSPSFVILSVSYENIFYVCFFSTLALWVQIEYKIRLKIAPRDRNRGLEKNQELLFHENLRTALFYLFFIQEAFFGTGNIASISSFTLDSIYRLIPIFNPFSQAALLLFKLLIPFIIISANLGILNQKLGIPPSTLFMIVLSISDILTLNFFYLVKNEGSWLEIGSSISAFCIANLQILYVIILEKASDFLVGDSYIPIEEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCD7</accession>
    <name>M7PCD7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_00014</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the assembly of mitochondrial and cytoplasmic iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871865.1">
        <property type="nucleotide sequence ID" value="XM_007873674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCD7"/>
    <dbReference type="STRING" id="1069680.M7PCD7"/>
    <dbReference type="GeneID" id="19893712"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00014"/>
    <dbReference type="eggNOG" id="KOG1120">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069054_0_2_1"/>
    <dbReference type="OrthoDB" id="333486at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036455">
        <property type="term" value="F:iron-sulfur transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000001">
        <property type="entry name" value="Iron-binding protein IscA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050322">
        <property type="entry name" value="Fe-S_cluster_asmbl/transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072:SF41">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="4">
        <location>
            <begin position="80"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00071673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR11570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="184" mass="21113" checksum="055595571427E493" modified="2013-05-29" version="1">MFFEERSACFWRCAKAEKLFLRPWLLKTNIHREFLQTYQKPSSTLWMHQNIGNPVGKKIREMTRSTSFLKTRSSPRKAAMTLTPRAVERLKELLNQPEPKMIRIGTKQKGCAGLSYLLEYVDEPGKFDETIIQDGVAILIDNRALFTIIGSKMDWIQDKLAARFVFDNPNATSTCGCQGSFSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7PDJ9</accession>
    <name>M7PDJ9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_03020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[ribosomal protein uS12]-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54156"/>
            <dbReference type="Rhea" id="RHEA-COMP:13816"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TPA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875071.1">
        <property type="nucleotide sequence ID" value="XM_007876880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PDJ9"/>
    <dbReference type="STRING" id="1069680.M7PDJ9"/>
    <dbReference type="GeneID" id="19896707"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03020"/>
    <dbReference type="eggNOG" id="KOG3844">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017005_0_0_1"/>
    <dbReference type="OMA" id="HDHEILY"/>
    <dbReference type="OrthoDB" id="430522at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019826">
        <property type="term" value="F:oxygen sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031543">
        <property type="term" value="F:peptidyl-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140311">
        <property type="term" value="F:protein sequestering activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000639">
        <property type="term" value="P:negative regulation of SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.20">
        <property type="entry name" value="Oxoglutarate/iron-dependent oxygenase, C-terminal degradation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019601">
        <property type="entry name" value="Oxoglutarate/Fe-dep_Oase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043044">
        <property type="entry name" value="TPA1/Ofd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039558">
        <property type="entry name" value="TPA1/OFD1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051842">
        <property type="entry name" value="uS12_prolyl_hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117:SF0">
        <property type="entry name" value="PROLYL 3-HYDROXYLASE OGFOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13661">
        <property type="entry name" value="2OG-FeII_Oxy_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10637">
        <property type="entry name" value="Ofd1_CTDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="9">
        <location>
            <begin position="89"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="480" mass="56022" checksum="9E9682742E95ABC9" modified="2013-05-29" version="1">MIFQKNIIQLNLMNIVKVRQEILENLAFSEKETDIYKVFQTGDLENLSGLEEDERKKLSSLIKLRDALYSNEFRCFISKVTGCGYLSGKMIDISVNIYGQGGHLLNHDDVIGTREVSFILYLVDPDEAWLPSYGGALRLYPTVRPSFPDCDYEKAIFPVWNQLCFFQVQPGRSFHDVEEVYQENKWRLSISGWFHRPQPGEEGWQEPKISSENVLSTLQILHSDIQNYDEPRMEPKICSITFNDEFNEFLKDHLSYLKDWINPEYLNYEKMMQLRETFLDYSVLELPNFLESTLSNHIKNWILDIEKSSSIQTLLDISPPWKLAKPLHKHRYLYIDSPDSSFDSPLISLLQNLFNHPSFHQWIHFCTTLIPSTFSALIRRFRPGLDYTLAIPHTSLSPILDLILSLTPSGHWDHGKNGGYHLYMTPPTPIHSILFNSNPSWNTFHFILRDSGVLHFIKYLSLYSQASRWDILSHFYFSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7PE94</accession>
    <name>M7PE94_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02941</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874985.1">
        <property type="nucleotide sequence ID" value="XM_007876794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PE94"/>
    <dbReference type="STRING" id="1069680.M7PE94"/>
    <dbReference type="GeneID" id="19896628"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02941"/>
    <dbReference type="eggNOG" id="KOG1943">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EPHEAWH"/>
    <dbReference type="OrthoDB" id="10253476at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058033">
        <property type="entry name" value="ARM_TBCD_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022577">
        <property type="entry name" value="TBCD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="BETA-TUBULIN COFACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23579">
        <property type="entry name" value="ARM_TBCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25767">
        <property type="entry name" value="ARM_TBCD_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12612">
        <property type="entry name" value="TFCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="3">
        <location>
            <begin position="272"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D C-terminal" evidence="2">
        <location>
            <begin position="849"/>
            <end position="1035"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1130" mass="131204" checksum="2D070F91FE51C6FA" modified="2013-05-29" version="1">MEEDDKEIYALKNGQEVVKKFKEDLLEFLKSFIDINWNVEKIICPLNIFQEQPELLDSELENLIHPVIDVIIKEIKNKVSCDFFLYINRLCYILYIYTKICGFKTIIKYFYNDFYLFESILFYMQNIPQEDTELWITRYILLLWLSLLCMIPFDLSRINSDLSGNTNIIDSLLVLCKRYLSISGKERDAASILVGRLLTRKDTYKLHLPSFISWIRDTWILETTSDFMKIGLLSSLCNIFKSNDRIFLLTIANDTFLLLQLITRNKHSNDKIRHLTTKLFQRVCLCFLKPHEASWIHKIEQNSLAKNLGIKGIDIQELSADIDDVALHPAIEECLYLLLENISDTSTIVRYSSAKGISKIISHIPESNANQVISTVISSIKDLDGSYSIETSNDIVWHGVSMTIAEFCRRGLLLPYRLREILPILLKALTFEQRRGTQYLGNNVRDAACYISWSIFRRYSIDNVIHLFPMLAESLLMVAIFDKETNVRRAASSAYQEGVGRYGESIFPHGIEIIKEMNFYTLATKRNSYLNVCFHLFKFNEYQDLIISYLTEKMAYHYDKKIRDLSSQILGKIAEINPSIVSKAIPVLLMNFEKKDIIMQHGTLEILAKILTKVQYKDIPSDIIQKFEELICEEMLPKNTLRIYPDIYGSICRYIIEISNTKYAKEACLLQWMDYIKCSLKIDSIHYEASQAVSSLAKRFDLRLQLNEFIIHIKSNFNKQDTFTNGLLCVLGKIEYFENYQDILELLVLVLIEITPLSDITFKKNSIKALGEILYSSKKHSSLSSFNIQYLHLDKLTQLFLNGLNDYSTGFAGDVGSWVRKESMISIFYILELAFDYNIDYFLTDAIFHSIIGNLLRQTVEKLDSLRVVAGSQLLNIVNLCQNMKKSYFSQSIELIKNSLKRIHDWRIPRNVIPNIIQLLCIREYQEYILIGLINSINGNESLTKEIEHHLIFYLINLPIEKNQSNSLTLLNFSNSLLKLCDSNITNNNFMICFMIFCNILFERLIFESLVGKFDFEHLFNCIRKSSYKSKSIQKISLSIKTYVEISKLSIKIASESLNELLLLLQHSYPVIRARAAEGLYMVLTEKELNISNQELYSNLINILIKTSWMESIEENKQYVEILQNSVLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7PHT7</accession>
    <name>M7PHT7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01778</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873746.1">
        <property type="nucleotide sequence ID" value="XM_007875555.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PHT7"/>
    <dbReference type="STRING" id="1069680.M7PHT7"/>
    <dbReference type="GeneID" id="19895472"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01778"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_433535_0_0_1"/>
    <dbReference type="OMA" id="YGRDRCA"/>
    <dbReference type="OrthoDB" id="6407164at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031138">
        <property type="term" value="P:negative regulation of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12523">
        <property type="entry name" value="RRM2_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000064">
        <property type="entry name" value="Differentiation 1 negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000120">
        <property type="entry name" value="Negative regulator of differentiation 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000400">
        <property type="entry name" value="Negative regulator of differentiation 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF8">
        <property type="entry name" value="RNA-BINDING PROTEIN MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="131"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="222"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="354"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="445"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="631" mass="70603" checksum="FD4E9FD09EDDD53D" modified="2013-05-29" version="1">MHDEHKDNVLEHHETTISQKESCIKTNNKKENIDIVEEFPTSMEGVNCNIVNQQGFTTVVPSQHLTASPSVSHTPSFPAHGLGVSSYTQNSMGNTGYAEVGAPGLLDPQFPLFPQFYGNIPLLTDIPKLRRTIYIGNIPNEATVNEILSQVRTGPIESVRLLPDKNCAFISFLEPSPAALFYEDAIMKKLSFHGKEAKIGWGKPSSVSSTVMLAVQQSGATRNVYLGNLPENITEEEIKEDLSKFGTIDQIKIVKNKGISFVHFLSISNAMKAVQQLPMEHKWANRKISYGKDRCAQSFRHHSTIPHDHILLNNLGMNHLTSQMTTMNLILPNYTNYHDLGHSCPDSHSIIGNRTVYLGNIHPETTVEEICNVIRGGILHNIKYFPEKHICFVTFVNPASAMLFYNVSVAQGLIIHNRKLKIGFGKHSGLLPSSIAIAVTSGATRNIYIGNTNENITVVKLKKDFSEWGEIELVNMLREKNCAFVNFTNISDALKAIEGIKTKEDYKRFKINFGKDRCGNPPKQIINQNDHIALSQPRITRTGFNMFHPSPDIPFTTNITNATHSEEKFVNEIPYTNYPPIENNGNIDTYPKSLSPILYNSTTYNDSSTNNGKNNQLTYEITHDHKINEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7PHW5</accession>
    <name>M7PHW5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01807</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873776.1">
        <property type="nucleotide sequence ID" value="XM_007875585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PHW5"/>
    <dbReference type="STRING" id="1069680.M7PHW5"/>
    <dbReference type="GeneID" id="19895501"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01807"/>
    <dbReference type="eggNOG" id="KOG2740">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026996_6_2_1"/>
    <dbReference type="OMA" id="INVHFTI"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14837">
        <property type="entry name" value="AP3_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="6">
        <location>
            <begin position="178"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="414" mass="47451" checksum="A0AF96C013F9DE4C" modified="2013-05-29" version="1">MNSIKTLFILNKKGNIIFEHHWYGHTSKNIVALFISEYKKNIFHENSHIPIISCKDGILIHIEYNNIILLCVIASEIDPLYVIEFLYRIVDILEEYLGQDATKKLVLEKNFEIIIQLLNEMMDYGYPMITEPNALKDIIPPPDTVNKILNIAGLKRSCIPSGILSPIIWRKANVKHSRDDFFIDIIEELKAIINKHGKFITLFSKGKIICLSNISGVPNIILNMKSKYHLFYSSFHPCLYSSHQTPSLEQLSFIPPDGKFTLMTYGIELSDMLPSSLPISIEIKSGPNVGDFEIKLNIFNHLINNITIAIPISESCQLKYSKSTHGNIIFESKHEKKKIIWKLNKTETCSFASMKFTLDKMKIPPNYLITKFTCTGWIISNIKVESLKIISNPDAKYYKGIRYTTVANEIVVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7PIN8</accession>
    <name>M7PIN8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Histone deacetylase</fullName>
            <ecNumber evidence="14">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PNEG_01563</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="14"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873514.1">
        <property type="nucleotide sequence ID" value="XM_007875323.1"/>
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    <dbReference type="AlphaFoldDB" id="M7PIN8"/>
    <dbReference type="STRING" id="1069680.M7PIN8"/>
    <dbReference type="GeneID" id="19895258"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01563"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="73273at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
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        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF14">
        <property type="entry name" value="HISTONE DEACETYLASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="12 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="11 14" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="18">
        <location>
            <begin position="20"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
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    <feature type="binding site" evidence="16">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="181"/>
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        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
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    <feature type="binding site" evidence="17">
        <location>
            <position position="264"/>
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        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
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    <feature type="binding site" evidence="16">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
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            <dbReference type="ARBA" id="ARBA00004496"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
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            <dbReference type="ARBA" id="ARBA00022490"/>
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            <dbReference type="ARBA" id="ARBA00022853"/>
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            <dbReference type="ARBA" id="ARBA00023163"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
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            <dbReference type="PIRSR" id="PIRSR037913-1"/>
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    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMR10304.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="375" mass="43015" checksum="00CFA23BC50895CA" modified="2013-05-29" version="1">MKRIGYAYSEYYEQLCNKLPSNLNRSSFIHSLIKAYGLFDKFAIITPEKASFASLSGIHDDKYISYLLKDYKKENDNISEEDSENVECDLEEEISLFGLDYDCPIFPELPEYVEFLAGTSQTSARLLGNDIFDIAIHWDGGRHHAKRSKASGFCYVNDIVLSIMELRKYYQRIMYLDLDLHAGDGVESAFLHSKNVLTLSLHRYDPGTGSLDLIGKGKGKYYALNVPLKKGLTDENFLLLFDHIIQPTFIKFNPDVIVIQCGCDGLFEDTYKEWNLTSQAYVLCLENILKWKKKLLILGGGGYKNTIVSRCYALLTSVILGVKIQNDIPEHDFFNHYAPDFELFLNKGHIENENTQEYIEYTINTLQLYINNIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJ52</accession>
    <name>M7PJ52_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_01197</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 12">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873113.1">
        <property type="nucleotide sequence ID" value="XM_007874922.1"/>
    </dbReference>
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    <dbReference type="STRING" id="1069680.M7PJ52"/>
    <dbReference type="GeneID" id="19894894"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01197"/>
    <dbReference type="eggNOG" id="KOG2906">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093932_3_0_1"/>
    <dbReference type="OMA" id="MEFCDEC"/>
    <dbReference type="OrthoDB" id="282152at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10509">
        <property type="entry name" value="Zn-ribbon_RPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034014">
        <property type="entry name" value="Zn_ribbon_RPC11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF12">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="13">
        <location>
            <begin position="65"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="4"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="4"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR10484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="109" mass="12622" checksum="9ABE1BA4412DEBE5" modified="2013-05-29" version="1">MIFCPACGNHLLIGTSIAGYNRFECRTCPYEFPIDRYLYSKRMMKQKEVDDVLGGEKAWDNVDKTDAQCPATDCGSLKAYFFQIQIRSADEPMTTFYKCIKCGYRWREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7PK18</accession>
    <name>M7PK18_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00922</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872835.1">
        <property type="nucleotide sequence ID" value="XM_007874644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PK18"/>
    <dbReference type="STRING" id="1069680.M7PK18"/>
    <dbReference type="GeneID" id="19894620"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00922"/>
    <dbReference type="eggNOG" id="KOG1906">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013572_0_1_1"/>
    <dbReference type="OMA" id="LIGWLEM"/>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990431">
        <property type="term" value="P:priRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140746">
        <property type="term" value="P:siRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000006">
        <property type="entry name" value="non-canonical poly(A) RNA polymerase PAPD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000003">
        <property type="entry name" value="non-canonical poly(A) RNA polymerase PAPD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="9">
        <location>
            <begin position="87"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="8">
        <location>
            <begin position="280"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR10774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="419" mass="48803" checksum="140FE9A252F03259" modified="2013-05-29" version="1">MDSFAQEEDYIKFDFSDNELWKKIEKESFEPSNPRKGFFQKTAAKMENFFKRKRLENDTLANKRFRREIEAPWAKDYSEETSVSRILHREILDFADFISPTKEEHFARELVIQRINSLIQKHWKNVQLCVFGSFDTMLYLPTSDIDLVILSSGSRIYETKKDLHKLSRYLRSSNVAKDIQVITGATVPIIKYIDTLTQIHVDISFNKPGGLISANIIKQYMKDHYALKPLVMFIKHFLNMRGLNEVFLGGLGSYSIICLVISFLQRHPKLLSKEIKEQDNLGVLLMEFFELYGKLFNYNEVGICIDNGGKYFSKRSRGWSKSNQPFLLSIQDPADPENDIAKSSRCILKIKATLGGAFDLLASRLYHVNKTIRPKLHYKRKKRDIYIDSILSAIVSIDTDIIEHRQMLKQIYAENEKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7PKQ9</accession>
    <name>M7PKQ9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease Z</fullName>
            <ecNumber evidence="4">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_00648</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872546.1">
        <property type="nucleotide sequence ID" value="XM_007874355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PKQ9"/>
    <dbReference type="STRING" id="1069680.M7PKQ9"/>
    <dbReference type="GeneID" id="19894346"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00648"/>
    <dbReference type="eggNOG" id="KOG2121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006220_0_0_1"/>
    <dbReference type="OMA" id="INYICQL"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07718">
        <property type="entry name" value="RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027794">
        <property type="entry name" value="tRNase_Z_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23023">
        <property type="entry name" value="Anti-Pycsar_Apyc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13691">
        <property type="entry name" value="Lactamase_B_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNase Z endonuclease" evidence="11">
        <location>
            <begin position="6"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR11049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="789" mass="90512" checksum="B9D293B82CB12F03" modified="2013-05-29" version="1">MKSFVQIVQIPSADTNFQPSILMHCDKKRYLFGAGEAIQRTCIGRKIKTRKIHDVFLTFGSRGVWEGFGGFPGLFLTMADQNRFISDITVHGPRNTMYLMLTLRHFIYRPNIKIKINEFKSEKDIFVDENVTISPVICAPCNYELVNKSQEIEFCDKKRSFEEYVKDIHDNFESIQEMVFYSNDGKVKISCFEDIQKILSNFDNTKSKTSQKDHFKMINIERNVKNMLQTVPFPISVTYICEGHTQPGKFNPIAAKTLGVTPGPQFGRLSRGESIILDNGNVVHPYQVLGESRPGFIFIIVDCPDKNYVDSLVRKDIWNDYYKSGTKRVQLMIHMVNEDVLNDPGYINWMHQFSENVQHIISCPSLCSDFITHQKVALQQLKLNKLSDNHFPLPQCMTFQSKKKGINIKNLHITDIKPLQKFILEPNPLFIEDEVLLPIDLKSPENFRGLDVFLSLAKEANENILRDQEKFYTKSNIPGSNVKVITLGTGSALPSHYRNVSSTVLRIPGHGSVILDAGEGTLGQLSRQFGPDLDSFLKDLKWIYISHLHADHHLGTIRILKQWNKVNYENDKVIYISAPWKYFCFLQEYSNIEDFGWGRVRTISNGDVCEDFTLKKGPSNLHMNSVNLNNLLKDLSLSSFSTVNAIHCPWSFCMQFTHLDGWKVAYSGDTRPNENFVKLGMNSTLLIHEATLDDDKLEEAIKKKHSTTSEAIDIGKRMNANFTLLTHFSQRYPKIPNFIMNDNNNQNRLGIAFDGMEIEFSDLWKLPYYSNALKVLYSDEFNEKDLISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7PKT4</accession>
    <name>M7PKT4_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00678</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872576.1">
        <property type="nucleotide sequence ID" value="XM_007874385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PKT4"/>
    <dbReference type="STRING" id="1069680.M7PKT4"/>
    <dbReference type="GeneID" id="19894376"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00678"/>
    <dbReference type="eggNOG" id="KOG3506">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177289_1_1_1"/>
    <dbReference type="OMA" id="HCFREIA"/>
    <dbReference type="OrthoDB" id="10252683at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.830.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="entry name" value="30s Ribosomal Protein S14, Chain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_uS14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039744">
        <property type="entry name" value="RIbosomal_uS14_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_uS14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004424">
        <property type="entry name" value="PRK05766.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010:SF2">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR11079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="56" mass="6582" checksum="3B3B06C7129E1D26" modified="2013-05-29" version="1">MAHDQVWFSRPRSYGKGSRGCRVCGHVAGLIRKYDLNICRQCFREYAVNIGFHKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7PL28</accession>
    <name>M7PL28_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_00768</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872670.1">
        <property type="nucleotide sequence ID" value="XM_007874479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PL28"/>
    <dbReference type="STRING" id="1069680.M7PL28"/>
    <dbReference type="GeneID" id="19894466"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00768"/>
    <dbReference type="eggNOG" id="KOG0610">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_5_1"/>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05574">
        <property type="entry name" value="STKc_phototropin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001236">
        <property type="entry name" value="AGC/RSK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000121">
        <property type="entry name" value="Serine/threonine-protein kinase nrc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45637">
        <property type="entry name" value="FLIPPASE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="239"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR11174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="632" mass="72387" checksum="7500EAA719EE11D5" modified="2013-05-29" version="1">MELEKTSTIQHKCQRNVLRSIFVHKRLRGEENSLVNNLVHPKFPQKLKCFFKFNHNNRNTNCSITDKSTEHNVLFIEKNHKRDGNFGEYGYLSERKNTYTKDKKQVLCFSVKRDGTIKNTVSKSYFIKDENMVQFFQKINPMSYGRFNFRKLKAQKSKTSPPEISVTLEKNDNIKAFPQINRKSSTSEIHTIDSADKSSKKYYLNVPSSGKLKKQNNFLRTYSSNSIKICSVEVGPSSFDKIKLLGKGDVGKVYLVREKKTRRLYAMKVLNKKEMIKRNKIKRVLTEQEILATSNHPFIVTLYHSFQSDKNLYFCMEYCMGGEFFRALQMRPGKCLSEDASRFYAAEVTAALEYLHLMGFIYRDLKPENILLHHSGHIMLSDFDLSKQSAPGGAPTMIVSKSVSGSFPAIDTRSCIADFRTNSFVGTEEYIAPEVIKGCGHTSAVDWWTLGILTFEMLFGVTPFKGKNRNITFTNILKNDVVFPEISYQQISSSCKSFIRKLLIKDENRRLGSKAGASDIKLHPFFRNTQWALLRHTRPPIIPALTKNLENQDFRDIKESLSIDIDSSQNIKATSTIEFPLETWLPSNSGASIDPFDSFSSMTLIHEGESNDSIFNYCDETLNKEEESPACQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7PL87</accession>
    <name>M7PL87_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 11">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="1 11">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 11">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_00818</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1 11"/>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872725.1">
        <property type="nucleotide sequence ID" value="XM_007874534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PL87"/>
    <dbReference type="STRING" id="1069680.M7PL87"/>
    <dbReference type="GeneID" id="19894516"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00818"/>
    <dbReference type="eggNOG" id="KOG2623">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024003_0_0_1"/>
    <dbReference type="OMA" id="FKLYCGA"/>
    <dbReference type="OrthoDB" id="337870at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000001">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054608">
        <property type="entry name" value="SYY-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF0">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="TYROSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22421">
        <property type="entry name" value="SYY_C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 11 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004083017" description="Tyrosine--tRNA ligase" evidence="12">
        <location>
            <begin position="29"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine--tRNA ligase SYY-like C-terminal" evidence="13">
        <location>
            <begin position="347"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR11229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="415" mass="47773" checksum="740A99EA4F1F2D07" modified="2013-05-29" version="1">MGVDPTGASLHIGHLVVLLPLLHFYLKGHFCYGIVGGGTSRIGDPSGKMKERKNMSLECITDNCLKIENQLDKFFKNGTAYALKRGYDSSKIGKYYIINNLTWYNQLSLFDFLKIVGSNIRLKRMLSRDSVKNRLESDRGINYSEFTYQLLQAYDFWYLNKHHNVSLQIGGSDQWGNIVSGIELINKMNPQENQTDSLIFRKEPYGMIVPLLLKKNGEKIGKSSGNAIWLNPDMFSPYELYQYFIQSSDEIVEKYLKFFTLLPLDVIYEIIKQHSNNPEKRYAQHKLAEEIVMLIHGQEEMEKSRTVAKLLFSNQEKDKELEISHIFKVLSDKQDIITLSKKKVIGMTISQIIRESKVISSKSKINKLIQNGGVCNNKEKITNPLTHVTEDWLIGKKFLILKLGKKRHIIINVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M7PMR1</accession>
    <name>M7PMR1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00182</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872044.1">
        <property type="nucleotide sequence ID" value="XM_007873853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PMR1"/>
    <dbReference type="STRING" id="1069680.M7PMR1"/>
    <dbReference type="GeneID" id="19893880"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00182"/>
    <dbReference type="eggNOG" id="ENOG502SDUV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2251201_0_0_1"/>
    <dbReference type="OMA" id="SMNECIR"/>
    <dbReference type="OrthoDB" id="6224010at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977:SF5">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR11749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="104" mass="12694" checksum="5599E33ABB7DB6F8" modified="2013-05-29" version="1">MSRLWSFHDEEEIRKIFMKNLNIACYDVIKKFAECASGKTFSTLWKCHSEKQSMNECIRLNALPENYDRARDIYMERIQMNRILKEKKQNSEIYQEREEKIYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWU9</accession>
    <name>A0A0W4ZWU9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major surface glycoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_04329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="KTW32853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613333.1">
        <property type="nucleotide sequence ID" value="XM_019757841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWU9"/>
    <dbReference type="GeneID" id="30671602"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04329"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KTW32853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="71" mass="7937" checksum="962A9672D656276D" modified="2016-03-16" version="1">MTSTSTVTSTVTLTSMRKCKPTRCTSDSSKETETQKEEEKEEEVKPNEGMKIRVPEIVKIMLLGVMVIGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWY1</accession>
    <name>A0A0W4ZWY1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major surface glycoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_04309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="KTW32878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875193.2">
        <property type="nucleotide sequence ID" value="XM_007877002.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWY1"/>
    <dbReference type="GeneID" id="19896822"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04309"/>
    <dbReference type="OrthoDB" id="10540739at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006933920" description="Major surface glycoprotein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KTW32878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="15165" checksum="1F611C3056F4BF15" modified="2016-03-16" version="1" fragment="single">MRIAFFALFAQLSYVLGSFLRDRDLPNEEDVYGYENFGLDPNSPEPSEFLNIIEMLRNAKRLGSGKINQGQFLSNRKARRDFDLCRSCNRPGVDYFRKSDYDGFFSEDFSSEDYSQDKRWVEEVAQKEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWY2</accession>
    <name>A0A0W4ZWY2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation machinery-associated protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_04312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMA16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="KTW32881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875319.2">
        <property type="nucleotide sequence ID" value="XM_007877128.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWY2"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZWY2"/>
    <dbReference type="GeneID" id="19896939"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04312"/>
    <dbReference type="OMA" id="WAYIATI"/>
    <dbReference type="OrthoDB" id="270284at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.170">
        <property type="entry name" value="Translation machinery-associated protein 16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021346">
        <property type="entry name" value="Tma16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038356">
        <property type="entry name" value="Tma16_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349:SF2">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11176">
        <property type="entry name" value="Tma16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KTW32881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="19494" checksum="D8E0F06178F5C937" modified="2016-03-16" version="1">MPKVLNLKKIQRKKGINSAHPKSRKAKQIQRSIDREDRIKKERKIREKRRDIQISRSIYFKSIVELENITKLNLDELNKLIERYIHRNDSKIKGSPCSDLHPRHSSKKEAFKQVFYNEQNEYKNGFHVPDLTDQKNVLALKNWTGNYNDLHTLKFIRVKKEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NI49</accession>
    <name>M7NI49_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_03401</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875486.1">
        <property type="nucleotide sequence ID" value="XM_007877295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NI49"/>
    <dbReference type="STRING" id="1069680.M7NI49"/>
    <dbReference type="GeneID" id="19897088"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03401"/>
    <dbReference type="eggNOG" id="KOG0703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023062_3_3_1"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08839">
        <property type="entry name" value="ArfGap_SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000010">
        <property type="entry name" value="Stromal membrane-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044732">
        <property type="entry name" value="ArfGAP_SMAP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF7">
        <property type="entry name" value="ACTIVATING PROTEIN FOR ARF, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G09120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="3">
        <location>
            <begin position="14"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="468" mass="53361" checksum="D27BD38D7287DE88" modified="2013-05-29" version="1">MSRSISKEKAESNTEVLKMLLKLPGNKYCSDCKRNDHPRWASWSLGIFLCIRCSGIHRSMGTHISRVKSVDLDSWTNEQLENMIRWGNARANKYWEAKLIPGHIPSESKIDNYIRTKYETKRWVMDGPIPDPSTLDEGNNNEIIHDLVLDHSLEKKQFSSIVPKNTKQIYTKDYQILNNLFSFSEKKEVSLHHQNSPSQQNSIKSKEPLFKSNLKNYTNILESHEPHSSKIHDKSSRAVLKTSILSLYSTTSTSQPNILSKSSVKDACLHEDQQTSKHESKLSDSFKDISKSVQELNISEEQKISHTSESSHQFSNPAVSYLLNTQKFSPVSASHDITATKDNASKINRKQSYSKGISSNNKIFDTESLCLKSFTTDVSKIVPNPDKDPFSKQWDNDSLTFNAFQPSNFFADSDTLSFHTSPWSTDEPKEIQRNSTNSQKDTLHKDGIHDKSILFYDDSIISTTDVWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NKC9</accession>
    <name>M7NKC9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Restriction of telomere capping protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02438</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat RTC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874445.1">
        <property type="nucleotide sequence ID" value="XM_007876254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NKC9"/>
    <dbReference type="STRING" id="1069680.M7NKC9"/>
    <dbReference type="GeneID" id="19896131"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02438"/>
    <dbReference type="eggNOG" id="KOG0269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010233_1_0_1"/>
    <dbReference type="OMA" id="EPMWLIS"/>
    <dbReference type="OrthoDB" id="60955at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061700">
        <property type="term" value="C:GATOR2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16693">
        <property type="entry name" value="mRING-H2-C3H3C2_WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037590">
        <property type="entry name" value="WDR24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049566">
        <property type="entry name" value="WDR59_RTC1-like_RING_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17120">
        <property type="entry name" value="zf-RING_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="107"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="152"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="196"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="753"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="814" mass="93577" checksum="504B020D2AE9275C" modified="2013-05-29" version="1">MNKKNDINNTFSWKAEGSLLSLAANAGKDRVAVVGREVLKILDVYSGGVTGEVNLYAGNRWSPTFSSCDVKWGCAGTRNILATASTNGSIVLWDLTKPYGHQIDRIITEHFRSVNRLAFNHLTGYWLLSGSQDGNIKLWDLRDRNGTSKYTMHGKAESVRDIQFNPNSVSEFVAAFENGTIQLWDIRKPNIYERKINAHNGLALTLDWYSDGRHIATGGRDKIIKVWDIFSDSRKPISVIQTMAPVSKIAWRPISNRRNENVLKTEIASCSLVSDYKIYIWDIRRPYIPSRVLDKHDNVTTGIIWKDENYLWSCSKDKTFIQHSVSTADIPLNSIPVISMDWSPLGDLSIVLQNRYSEMNYFNTEYLSSVEDESISRENKKHFRLHHRTSKTLNNIVSQLYKPLHISGTIVIPNLQYYGFTYLAQHYNITASPNLSVSQACENNANFALNIQKYRTSQTWKILQHLLENRKYPIKNSTHTNKTADTDNSIEHDYKNNDDLLFKMSLKNNINESKTLLNRASSVSRKNADMFLKSDRVGRHFRNNTESVISRQNVLDDGNIFDKNQENTNFNDEIHELYNFRDNFETISQSFNSDYTVCSFRNDFDREKHLKYSDTSNNNIFVKPRFTNIDTIENTCPWSINSLIQAVAEYYSEIGDIQMCATIVLLMGKYTNFDSLKIEKWIGEYIELLQKYRMFITMTEVINASSSLLIRALSQTETSVYIDCYCCHKPIVNQKENNTFSYCKCCRKIPNGCTICDIPVKGRYLWCQSCGHGGHTECLRNWFMNNYNHYGACPAIACTHHCGFFLDNCKVLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7NKE5</accession>
    <name>M7NKE5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Farnesyl pyrophosphate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02452</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874460.1">
        <property type="nucleotide sequence ID" value="XM_007876269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NKE5"/>
    <dbReference type="STRING" id="1069680.M7NKE5"/>
    <dbReference type="GeneID" id="19896145"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02452"/>
    <dbReference type="eggNOG" id="KOG0711">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028376_1_0_1"/>
    <dbReference type="OMA" id="CSWVVNQ"/>
    <dbReference type="OrthoDB" id="10257492at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:geranylgeranyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000006">
        <property type="entry name" value="Farnesyl pyrophosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01017">
        <property type="entry name" value="Polyprenyl_Transferase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="40943" checksum="DB9390C5D216C66D" modified="2013-05-29" version="1">MENNLITAKQRFERIFPLIVEDLNVYLKTLNIPQIGRDWFMKILHYNCLGGKLSRGLSVIDSYEILLDRSLNEEEYKKAAILGWTVELLQACFLVVDDIMDQSKTRRNQCCWYLMPNVGMTAINDSFMLQSSIFFLLKKYFREEPYYTSLMENFHDITFKTEFGQLLDLLTAPENNVDLSRFSMDRHSFIIEYKTAFYSFYLPVVLAMNMAGISSEDNLEQAKNILVPLGKYFQIQDDFLDCFGDPDIMGKIGTDIMENKCTWLINKALEKATPSQRKILEENYGKKNTDSELVIKKLYDELELCKEFEIYEKQVVTYILKLISKIDESRGLKKKVFTTFLDKIYQRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NL07</accession>
    <name>M7NL07_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02288</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probably involved in the biogenesis of the COX complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SURF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874282.1">
        <property type="nucleotide sequence ID" value="XM_007876091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NL07"/>
    <dbReference type="STRING" id="1069680.M7NL07"/>
    <dbReference type="GeneID" id="19895981"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02288"/>
    <dbReference type="eggNOG" id="KOG1563">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047737_4_2_1"/>
    <dbReference type="OMA" id="WYSRDVA"/>
    <dbReference type="OrthoDB" id="10040024at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF2">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="270" mass="31705" checksum="12B16941D0EB6C41" modified="2013-05-29" version="1">MIYNVYSFSIGTRYLTYTTFSRSSYVIKGLLTIIPITAFGLGTWQYYRLKWKSQLIKEFEKRISSEPLRLTKDVNFSDVLSLEYQKVLLTGRFKHDQEILVGPRLFEGKNGYHVITPIEIGDECKCLINRGWIPSYMADQSKRTEGLSSEEVTIQGLIRLPPKSNLFTPKNEPESKKYYYIDIEQMSKLTQSEYIYIEQLIDDFIMAPFLATKGKPIGKLAEIQIRNKHLEYMFTWYSLFIATLFMLYRVFKQPQSPLIARRANQIKRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLK5</accession>
    <name>M7NLK5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">coproporphyrinogen oxidase</fullName>
            <ecNumber evidence="4">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_03517</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875609.1">
        <property type="nucleotide sequence ID" value="XM_007877418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLK5"/>
    <dbReference type="STRING" id="1069680.M7NLK5"/>
    <dbReference type="GeneID" id="19897204"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03517"/>
    <dbReference type="eggNOG" id="KOG1518">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026169_0_0_1"/>
    <dbReference type="OMA" id="NTPYTEQ"/>
    <dbReference type="OrthoDB" id="15318at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="entry name" value="Coproporphyrinogen III oxidase, aerobic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018375">
        <property type="entry name" value="Coprogen_oxidase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003727">
        <property type="entry name" value="PRK05330.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755:SF0">
        <property type="entry name" value="OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="Coproporphyrinogen III oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01021">
        <property type="entry name" value="COPROGEN_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="417" mass="48915" checksum="2F28BD7C99A582D9" modified="2013-05-29" version="1">MNLQYLSVRYRYWFLHHPALIPLYLKECSFFSIKKISSLSICTLKSFPRLKYHICSGKGYFTKNCSIWGSGFTWIVVGGVFIYLNQNKKNAIQCQACTEQDATVDKSDIDEDSIFFRMHEFSSAKQIEIVKVLETLESKKFSCDVWKKDGIVGKSCVLQNGDVFEKAGVNISKVQKMLHPSAIEKIRKNHQCLKDVENITKFSICGLSLILHPHNPMAPSVHMNYRYIEVDNMNGSPKIWWFGGGSDLSPAYLFDEDAIYFHRTYKTVCDHYDKQYYPKFKKWCDEYFFIKHRKECRGIGGIFFDDLDDKDPEEIFSFVKDCLNAFLPSYIPVILRRKDMHFTPDEKLFQQIRRGRYVEFNLMYDRGTLFGLNIPESRVESILISLPLTSSWIYQYDLKDPREKQLTEVLKNPKEWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLP6</accession>
    <name>M7NLP6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Crossover junction endonuclease MUS81</fullName>
            <ecNumber evidence="16">3.1.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PNEG_03555</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 16">Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with EME1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the XPF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.22.-" evidence="16"/>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875648.1">
        <property type="nucleotide sequence ID" value="XM_007877457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLP6"/>
    <dbReference type="STRING" id="1069680.M7NLP6"/>
    <dbReference type="GeneID" id="19897242"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03555"/>
    <dbReference type="eggNOG" id="KOG2379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014329_1_0_1"/>
    <dbReference type="OMA" id="ELGDAMW"/>
    <dbReference type="OrthoDB" id="5963188at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048257">
        <property type="term" value="F:3'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21036">
        <property type="entry name" value="WH_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20074">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000005">
        <property type="entry name" value="crossover junction endonuclease MUS81 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000001">
        <property type="entry name" value="Putative Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033309">
        <property type="entry name" value="Mus81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047417">
        <property type="entry name" value="WHD_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047416">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451">
        <property type="entry name" value="CLASS II CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451:SF0">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 16" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 16" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="17">
        <location>
            <begin position="280"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00058015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU369042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMR08117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="554" mass="65102" checksum="865AFFE7EB163B3C" modified="2013-05-29" version="1">MQSCGNPLFLQWVSEWMQEAKEKNRKSYNVFKTAYNSLLSCPITFSDPSQVKKLKGIGNIISARLEERLKEYQRTHIDLNIQHQANIDDSFFSQLELHPKSETTQKSFQQKTKTQTSKTYIPGYRSKSFAILVALFKFNEDTAVSKEEILNIARHYYDISEHKNIHLLWNGMKILLEKEYVYKTVNPTRYYLTDSGKEVAAAISSSIFSNEIIEKEFPLNNEFKKNKKEIQENYHEIHMIKELDQNIETEKKTLKDIPKSLIHDTILNISTIQHNSYSIILLLDTREMKTQKDKEFIEYYLTKESIVFEFRTLELGDVLWIARCNTTKKEYILDFIIERKRLNDLANSIKDGRFHEQKFRLSKSCLKHVIYIIENCNYNFTDFNIEAIHSAISSTQIINGFFVKRLSGLMETIKYIVRLTRYISQIYKTQDLCIINNDNINLQTYTLQKKMINSTYSKHSYVIEYSTFSDFLSKTASLTLGDLFLKMLLTIKGVSPEKAIEIQKHFPTLNDLLTSYYKETIEYEREIMIAKKCTNYGRKSISPLLSSKIYKVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLR3</accession>
    <name>M7NLR3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PSP proline-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_03521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875613.1">
        <property type="nucleotide sequence ID" value="XM_007877422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLR3"/>
    <dbReference type="STRING" id="1069680.M7NLR3"/>
    <dbReference type="GeneID" id="19897208"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03521"/>
    <dbReference type="eggNOG" id="KOG2330">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014435_1_1_1"/>
    <dbReference type="OMA" id="KGEPIGQ"/>
    <dbReference type="OrthoDB" id="10260794at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007180">
        <property type="entry name" value="DUF382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052584">
        <property type="entry name" value="U2_snRNP_Complex_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785">
        <property type="entry name" value="SPLICING FACTOR 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785:SF6">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04037">
        <property type="entry name" value="DUF382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00581">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP proline-rich" evidence="2">
        <location>
            <begin position="295"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="593" mass="68597" checksum="1046A5BC2B4D3BCC" modified="2013-05-29" version="1">MLHVESPALNGLTVEENEKNRQKTKSRIRRDKKRRKKIREESIIESTIEHDKNTIVDKSLGLKNERLEGNENGENYVNNDSLSVFFELDENDPTFMSFKEIFDKFSVSVKESNDAEIENKGEIFYSDDNIEEEEEEEDMPKKLSRKKARRQNRLSVAELKQLVKNPEVVEWFDVSAQDPKLLAHLKAYRNTIPVPSHWMQKRDYLASKRGIEKPPFELPDFIRATGIMEMRDSVREKEDNQTLRQKMRARVQPKMGKLDIDYQKLYNAFFRFQTKPPMTEYGEVYYEGKEFETNLKERRPGDLSEELKEALNIPPGAPPPWLINMQRFGPPPSYPALKIPGLNAPIPSGAQFGFHPGGWGKPPVDEFNRPLYGDVFGIVQPQAPPDSGEPVERQLWGQLEDIEEESEQEEDEEDDDEKDISMNNQEMFDGIETPLGVETPSGMVSSVPSGIETPEYIELRKQRISEVEHDSGRSFYQPLAEQQSRIKGFMGSEHIYDLSSINKLPVLDAPEPRKKKKNGVDVSLDPSLLENENNRSLAEKQLREKYEEAQRMQRIDPKGWDEDLSEMVAEQAAKQSAKRQKKVNEQKKEKFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLZ6</accession>
    <name>M7NLZ6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein ORM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873854.1">
        <property type="nucleotide sequence ID" value="XM_007875663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLZ6"/>
    <dbReference type="STRING" id="1069680.M7NLZ6"/>
    <dbReference type="GeneID" id="19895574"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01880"/>
    <dbReference type="eggNOG" id="KOG3319">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072117_2_0_1"/>
    <dbReference type="OMA" id="STHYTHF"/>
    <dbReference type="OrthoDB" id="1932233at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007203">
        <property type="entry name" value="ORMDL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12665">
        <property type="entry name" value="ORMDL PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04061">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018147">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="21870" checksum="0BD83716159B7BBA" modified="2013-05-29" version="1">MSYIILEQIQGSDILFYDMCRRSSSIIHDVQASTADDSLDQGSQSNFNCNWGLGAWIIHIVVISYLKIFYNAFPAVSQELSWTLTNLTYMLSSYIMFHWVKGIPFEFNSGAYDNLTMWEQMDNGAQYTPAKKYLTAVPITLFLLSTHYTHYDFWTFFINLWALLMVLVPKLPSTHRKRIFGINKFDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NME0</accession>
    <name>M7NME0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_03222</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875285.1">
        <property type="nucleotide sequence ID" value="XM_007877094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NME0"/>
    <dbReference type="STRING" id="1069680.M7NME0"/>
    <dbReference type="GeneID" id="19896909"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03222"/>
    <dbReference type="eggNOG" id="KOG2372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029204_0_0_1"/>
    <dbReference type="OMA" id="HYGLWCD"/>
    <dbReference type="OrthoDB" id="26679at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032984">
        <property type="term" value="P:protein-containing complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="5">
        <location>
            <begin position="35"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="218" mass="24751" checksum="5799403E35604FA3" modified="2013-05-29" version="1">MKEQTSSNKRKSRSFVLPPLVPISFYGYNKEKSSVYLTRELAEGIRKFIPRRLQLQEKWKLVYSLDHHGSSLLTLYLKSSQNRGVFSSRPGFVLVVKDSNNNIFGAFINEYFHPSTSYYGSRECFVWKVLSNDSFDNINGSAFRFKAFMSTGINDFMVLCDNSFLSIGGGDGKYGLWIDGQLEKGISASTQTFNNDPLSDSVKPGERFDILGVEVWKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMP3</accession>
    <name>M7NMP3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TFIIE beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01711</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873675.1">
        <property type="nucleotide sequence ID" value="XM_007875484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMP3"/>
    <dbReference type="STRING" id="1069680.M7NMP3"/>
    <dbReference type="GeneID" id="19895405"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01711"/>
    <dbReference type="eggNOG" id="KOG3095">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056580_0_1_1"/>
    <dbReference type="OMA" id="RTKKDNH"/>
    <dbReference type="OrthoDB" id="5323195at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001097">
        <property type="term" value="F:TFIIH-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054600">
        <property type="entry name" value="TFA2_E-tether"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040501">
        <property type="entry name" value="TFA2_Winged_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016656">
        <property type="entry name" value="TFIIE-bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003166">
        <property type="entry name" value="TFIIE_bsu_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22254">
        <property type="entry name" value="TFA2_E-tether"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18121">
        <property type="entry name" value="TFA2_Winged_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02186">
        <property type="entry name" value="TFIIE_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016398">
        <property type="entry name" value="TFIIE-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51351">
        <property type="entry name" value="TFIIE_BETA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIE beta" evidence="7">
        <location>
            <begin position="22"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="241" mass="27415" checksum="7D2B67FD15460F6B" modified="2013-05-29" version="1">MANIKNGGNELNVKKPRNNIVYSQPDDSGVGNHLQSQLYYVLEYLKKNEAPKTSEEISSYLSIPLTTTFINILRTNERIEYDSYKDTYHFKPIHNIRSAASLVAFLNSSVTATGILVKDLKEGWSGAIDEIERLEKDGEILVLRTKKDGLLKSVWPNHCNDQESVDEEFKEIWHSLIIPAPSDLPHELENVGLKPTSIDPATIKRISVATSLQKQKKRRSNRGRITNTHLNSLKDYSDRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN42</accession>
    <name>M7NN42_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spc7 kinetochore protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_03121</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875179.1">
        <property type="nucleotide sequence ID" value="XM_007876988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN42"/>
    <dbReference type="STRING" id="1069680.M7NN42"/>
    <dbReference type="GeneID" id="19896808"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03121"/>
    <dbReference type="eggNOG" id="ENOG502S20P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_271914_0_0_1"/>
    <dbReference type="OMA" id="WSISHEI"/>
    <dbReference type="OrthoDB" id="5592879at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040850">
        <property type="entry name" value="Knl1_RWD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033338">
        <property type="entry name" value="Spc105/Spc7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013253">
        <property type="entry name" value="Spc7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28260">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT SPC105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28260:SF1">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT SPC105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18210">
        <property type="entry name" value="Knl1_RWD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15402">
        <property type="entry name" value="MELT_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08317">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00787">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spc7 kinetochore protein" evidence="3">
        <location>
            <begin position="728"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="961"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1192" mass="136619" checksum="490BCBEB2EC24497" modified="2013-05-29" version="1">MIDTKSPESKWESMRQGILDKVILDKENQSPNKNTGLVLNEGPYLKRSKSFGGESDEKFVKPLMAKQESRSTTLGMPNKGILKTSLCSLDYTHDSSCKNDLDNHTVIGIMQVALKDNEKDSERSETKKSQRRKSLNRRVSFANYASVRLYEKDQEFQSPNPTFPSKTTPSSKEKFLLSPIKRNFKSKKSSALNDSPKTPSPIKCISPVKPSKAYINSPIPMPQGQEFSDDIDHVDIESSENVFFSDIGNNHEKEFCNYQNKGIFKDIDGEMTMDLTEVISNPVFEKKNTQKIAMDLVDVASDSIPEEGDVEVTMDITKLLPCSIFEKSATEEPVIHLTHVPDSSVVERNNEIKMNSIITLGEIQKNQSKLFFNFQSLSDKKHNEKEPTMELHAIDNGSLKIDNHVDSDVVDMDTTKVVGGILRNLNGMDQKDGLTMDFTTTIGNILTVNEEITKDLDFSFNNVCLEKKLNIQRKMQSNTFSGCFSLDDFHKPIVVYEDDNTVDMDLTKIAPLVLEHENNLTLKNVKEEFVSLKHDSLPMDIDIKKSLNTELKSPQRIPRSGVLAIDALFGKNTLNNIRNISDTVVPIQLGSPKAAKLLKNRKSIGYFEEMKLVGLGSPTTKIIVGNKLTRENGMSESDIFTVNGLNILDRIAQLTPKKNVPFQLTPEKNIISSQLLSLHNISKDNILENSESKLKRNYENTLNNTYTISPTKKTCKSSNIKEYSDRLIETHDEDNFLPSITLTEFLKMTSISFLDGLTTTKRRETTFFPYLNTNPPTLKELVYTSSLTLPTLELYQFSCKELQKYISEGKEVVNKIEKDTSEENPLLFREYIYASHDIQVIMVGQFKLLKNYSRLYAKSVWYDWRDKLLLGLKEGLEKNLEGLKKDELIINESKPILNTCFPLIKQTYESLKEKIKHMKAIKEEISQCDQKELRKVRSSLFNINEELQGDTEDFEKLRKCISEIDDRLHELSEKQAKLNREIEEYKKVMKVNRCFEKGEIENIKKMLQILKSVTGWEVKRFFHDTVVFIYLDTIETTFNFIKNDASIKWNGGVKDKVKEFFFDYLEKRLKSCTVKEALSLICRIWYTATLIWSEFCLLKIRYPLLYNLTIENDQPLLQVTAKVFLPSSFSKFYVTFKLRHSILYEYPNLSNYDLIDIHIIYGNSNTSKILKTILEKISVGGIKALSFVCNEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNB0</accession>
    <name>M7NNB0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL6m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_01452</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873392.1">
        <property type="nucleotide sequence ID" value="XM_007875201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNB0"/>
    <dbReference type="STRING" id="1069680.M7NNB0"/>
    <dbReference type="GeneID" id="19895149"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01452"/>
    <dbReference type="eggNOG" id="KOG3254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065464_1_0_1"/>
    <dbReference type="OMA" id="RERHGLC"/>
    <dbReference type="OrthoDB" id="540873at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000006">
        <property type="entry name" value="50S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_uL6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_uL6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="9">
        <location>
            <begin position="42"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="9">
        <location>
            <begin position="112"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR10178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="200" mass="22384" checksum="66F16C66214BDF85" modified="2013-05-29" version="1">MKIMFKCVAFLRKSHIGSKPLFLPGTTKLEVLVATSSPNTKKIIVKGPNGCLSLFLPSYIHINHCSLTNKVKISVENSMIKEQRSMWGTARSLLSNMIIGVTEYHYVTLRLVGIGYKAFIENDSFLSLKVGFSHPIHLKIPDGVFITCPSSTQIILKGCDKAIVTQFAANIRKWKKPEPYKGKGIFVNDEKITLKNTKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNF6</accession>
    <name>M7NNF6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02929</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874973.1">
        <property type="nucleotide sequence ID" value="XM_007876782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNF6"/>
    <dbReference type="STRING" id="1069680.M7NNF6"/>
    <dbReference type="GeneID" id="19896616"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02929"/>
    <dbReference type="eggNOG" id="KOG1888">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003016_0_3_1"/>
    <dbReference type="OMA" id="KRKCCAH"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043573">
        <property type="entry name" value="Fig4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738:SF5">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="4">
        <location>
            <begin position="155"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="849" mass="99553" checksum="FABE5E0F04233051" modified="2013-05-29" version="1">MKIRTENAADVSFLVKFTLYETKTKFFIVGEDYSGTSFQVLKIDRMVEDELDLIEDETIYSKNEISKLLVTINEGNRNCGGISKVLVAWGICGFIRFTCGYYISFITKRSTVALLGGHYIYHINDTKLVPIAHSSILSKKSRSVLVEESRYLNIFQTLDLNKTFYFSYSYDITHTLQHNLTTHSCLKARTLDDYNEMFVWNYNLLNIAIKCLKNGSKWCIPIIHGFIDQANISVYGKSIYITLIARRSRHFAGARFFKRGVNSKGYVANDVESEQIVSEMLTTSFYTKDMKLNPKYTSYVQHRGSIPLFWSQDPNNMSPKPPIKLDIIDPFFSATALHFDNMFKRYKTPCIVVNLIKSRERARRESILLEEYTQAIYYLNQFLPEDKKIKYIAWDMSRASKTRGQDVILTLENIADEVLKTTGFFHSKILNDQSQNIKKKLKLQEGICRTNCIDCLDRTNAAQFVIAKKALGYQLFALGIIREPILNYDTDAINLLTEMYHDHGDTIALQYGGSHLVNTMSTYRKINHWTSHSRDIIESIRRFYTNSFVDAQRQSAINLFLGIKLPNNKHMLWDLTTDYYSRHTPQLNNIRRNYKYWYIPLNIDSSLDENCLSEKLKCNKCTDSDEYWSEYYKPKMLSTLDKMFAYKINSTLRYISLKYSSPKYFEFSPFVIRSLHGDVLEEDSSRSRPSNRDNLSYKKHKRQFAIQKILRKAEDKKIIRDTHEYNKAQKMERFHGLDAKNGPFLFPLPSQYVEINHFSTSSMMYKKEEYKNYLYRSYHIELLQEELSSRKSEYNQWISLTDISYIDKVKPSDKDLDLYIEHCEFPETLYPMKGTYSLNKETIQEAKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNG2</accession>
    <name>M7NNG2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Poly A polymerase head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02932</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874977.1">
        <property type="nucleotide sequence ID" value="XM_007876786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNG2"/>
    <dbReference type="STRING" id="1069680.M7NNG2"/>
    <dbReference type="GeneID" id="19896619"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02932"/>
    <dbReference type="eggNOG" id="KOG2159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019592_2_1_1"/>
    <dbReference type="OMA" id="NIHRATE"/>
    <dbReference type="OrthoDB" id="445712at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CC tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:CCA tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000019">
        <property type="entry name" value="tRNA nucleotidyltransferase cca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734:SF5">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734">
        <property type="entry name" value="TRNA-NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="6">
        <location>
            <begin position="43"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding" evidence="7">
        <location>
            <begin position="211"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="62954" checksum="D788855165363C61" modified="2013-05-29" version="1">MKKSYFSNEISKEIILNERENELKKLLLLVSEDCRRRGRPVILRFAGGWVRDKLLGLESNDLDVVIDTMSGYEFALCLNRYLRKNKAFQIGYSHVAKIERNPEKSKHLETATTHIMGIELDFVNLRSESYCKDSRIPIMEFGTPEEDSLRRDCTINALFYNLHTSEIEDFTKRGLEDMKLKRIATPLEPYQTFDDDPLRILRCIRFSSRFGFEIDLETKHAIMHPNIKKSLSTKISKERIGVEIGKMLEGVNPYGSLKLIYDLGLYENIFSTSSLMKPQKNLNCIPLAIELTKWIMQDKQENALKDELDSTLSSEHPISSILGNISVNPFEEHMDLLGGVKNNMIPWLLSILIPWKEQLVKNKKRNVQYSSVIVREGLKMSNYIANIVDDSFSYFQEAQKISIECINGIETRVSLGCFVRLVKKNWPFAVFLGLIDEILASFLPQMDKLENKYKIKRSKLEIEHLFDEKKSILNRYQSLLDKIHHENLQKAYSLQPIVNGHILSKTFGLKGPQIGVALEKVILWQLKNPEGTPEQCLSQLNLKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNJ2</accession>
    <name>M7NNJ2_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ubiquitin-40S ribosomal protein S27a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_02980</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875027.1">
        <property type="nucleotide sequence ID" value="XM_007876836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNJ2"/>
    <dbReference type="STRING" id="1069680.M7NNJ2"/>
    <dbReference type="GeneID" id="19896667"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02980"/>
    <dbReference type="eggNOG" id="KOG0004">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010412_2_0_1"/>
    <dbReference type="OMA" id="GVFMAFH"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000008">
        <property type="entry name" value="Ubiquitin-40S ribosomal protein S27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_eS31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038582">
        <property type="entry name" value="Ribosomal_eS31_euk-type_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="154" mass="17676" checksum="1555CBBC40013442" modified="2013-05-29" version="1">MQIFVKTLTGKTITLEVESLDTIDNLKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGAKKRKKKTYTTPKKIKHKRKKCKLPILNFYKVDADGKIQRLRSECPHPTCGAGVFMALHKDRRYCGKCGLTMVFDKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNP3</accession>
    <name>M7NNP3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCZ1/INTU/HSP4 first Longin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCZ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873508.1">
        <property type="nucleotide sequence ID" value="XM_007875317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNP3"/>
    <dbReference type="STRING" id="1069680.M7NNP3"/>
    <dbReference type="GeneID" id="19895254"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01559"/>
    <dbReference type="eggNOG" id="ENOG502RF5E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_450641_0_0_1"/>
    <dbReference type="OrthoDB" id="240546at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013176">
        <property type="entry name" value="Ccz1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043987">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056:SF0">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19031">
        <property type="entry name" value="Intu_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCZ1/INTU/HSP4 first Longin" evidence="2">
        <location>
            <begin position="15"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="606" mass="70928" checksum="00E6EAF2BECCC8BB" modified="2013-05-29" version="1">MTNINFISSEKCPLSYLCIFNPSFGISEGSLHNQILFFISETYISLNDQQRNIGLIQGIMEFSLNFGKKVSNEYIQSKNHVIIVIEVENGWYIAASFFSKFLRKNHIFFPPFTVLFNYLYQAYEQYRLVYGLLDYTLQKDGRKILESQLNEWWQKWVRNLDVTVNDPSILYSAINMGFITPDFRLKEKINKNINDLKASNERIIDLIISSVSPIFNYHKHNEGCLYSGDGTIPKNTIKILDKWLQHQIKELINKVDINKKNDQDNFRNNRDKNEKTTLSVSDPSVEFLNNNSNSSISLWKLSNFFTLSSISANISSYISSVFVRNNLHSVSKKRPCLYNYCSEDNNIFFKYNSGLGDFIYGFIEKHNSDSILSEKKLYIGDNQINQNINSSLNNPKSANDFDLKVLNLNYESDPQYISVSVYYSYPFVYLIALKGQNINTENSEKIFIRNKIFYTNLQCCLEKIAIDIETYFAESFENFNSFFWHIIFDPNTQELYTNVPYSKKNEDYLQVEKNLSTEDILHIHSHALSIFDKIKNSKNGNKINDYILKTSKNFWVCYLHVKEKHIILILKKNQHKENIIHTTIENIFQEAKKYVSKLFNLSDTHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNV0</accession>
    <name>M7NNV0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit A</fullName>
            <shortName evidence="7">eIF3a</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 110 kDa subunit homolog</fullName>
            <shortName evidence="7">eIF3 p110</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Translation initiation factor eIF3, p110 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TIF32</name>
        <name evidence="10" type="ORF">PNEG_02718</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874743.1">
        <property type="nucleotide sequence ID" value="XM_007876552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNV0"/>
    <dbReference type="STRING" id="1069680.M7NNV0"/>
    <dbReference type="GeneID" id="19896409"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02718"/>
    <dbReference type="eggNOG" id="KOG2072">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002096_2_1_1"/>
    <dbReference type="OMA" id="EHITNKR"/>
    <dbReference type="OrthoDB" id="18884at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.860:FF:000003">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.10">
        <property type="entry name" value="UVR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03000">
        <property type="entry name" value="eIF3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027512">
        <property type="entry name" value="EIF3A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054711">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3, THETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22591">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="317"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="795"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="848"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="586"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="671"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="848"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="907"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="956" mass="111524" checksum="D41B664394BB0048" modified="2013-05-29" version="1">MLLPQSKPENVLRRAEELIAVGQSPAALQLLHELILSRCSRNAAVSSLKPIMLRFVALCVDLRKGKMAKEALYQYKNIAQNTSVGTVEVVLKKFIDLVEEKVSEAQVHAEKLVLDTIDDLEASETPENIILSTVSGDQSKDRTDRAVVTPWLKFLWETYRTVLEILKNNARLEQAYQSAVNQAFSFCLKYSRKTEFRRLCDLLRTHLQNATKYSGQQHSINFNDPDTLQRHLDTRFSQLNAAVELELWQEAFKSVEDINNLLMLSKRQPKLLVMTNYYEKLGKIFAVSENYLFHALIWNKYFALISSQNKALSDKELERIASLVLLSALSIPVINITRSKGNNIMEIDDTKIRNTKLAALLSLSKPPTRSNLLKEALGKNILVHVRKEIKELCNILEVEFHPLNICQKVEPLIKIIAQDPDMAQYIKPLQHVILTRLFQQLSQIYETIQLDFLFNLVNFSEPFNIDSIYIEKFIMNACKKGELSIRIDHSSRSLTFETDVFTSHHTVTDSNIRLQSTPSELIRSQLSRIGKCLLTTVCIIDPSFLQERENQKNAANERAVNGIEKEQNETLARRALIEHRKEIVENMMICKEKEAATKRAQKLQQEQEAEQRRIAEEAKKREAERIKKEADAIRAEEARKLAGELKAKGALKVDVDDLEGLDTSKLRAIHLEQLEKETRDLNERLRITSKRIDHLERAFRKEELPFLKQLAIDRDASDKLFHEKSRKLKLEASRAKHDHMVALKHRFQRLHSDYMIYCDMFLEECKKQHNKQCKIANKALEKEKEDRRIAYRKKKEQEEKRRLEEEERKKKEEEERERIRQEELRLKAIQEENRARKEEELRKLDQMAEKQKQKELEVENKLRRKKEELFSNDHSYDRWSKKDRLPSNPSGEEKWRPGKGSWRLRVSEQTESTDSNLLNKSKLETLQKLGNKSLNTDQPSIAIYKPPAIRKESSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNY3</accession>
    <name>M7NNY3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01128</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873043.1">
        <property type="nucleotide sequence ID" value="XM_007874852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNY3"/>
    <dbReference type="STRING" id="1069680.M7NNY3"/>
    <dbReference type="GeneID" id="19894825"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01128"/>
    <dbReference type="eggNOG" id="KOG0423">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_5_3_1"/>
    <dbReference type="OMA" id="QPAKCGA"/>
    <dbReference type="OrthoDB" id="10069349at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061650">
        <property type="term" value="F:ubiquitin-like protein conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23804">
        <property type="entry name" value="UBCc_UBE2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="6"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="225" mass="25057" checksum="72488476E265998C" modified="2013-05-29" version="1">MALPRPISHRIAKEIQSLWASPLEGVRLLEVGDSTLTEVQAYIFGPGKCGAFKLRLQFGTEYPSVPPKCHFITKIFHPNVSSKGEVCVSILKKDWSPTVHVSHILLTVKCLLIHPNPESALNEEAGRLLLDNYESFSKHARLITSIHSVKPGIAWMELTGTHLSSDFPTLTPLGDSNTTSNLSFGSENFAKGRENIPVTENNHDLDNKILEKKKIDTRKRGLKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNZ6</accession>
    <name>M7NNZ6_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MT-A70-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874788.1">
        <property type="nucleotide sequence ID" value="XM_007876597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNZ6"/>
    <dbReference type="STRING" id="1069680.M7NNZ6"/>
    <dbReference type="GeneID" id="19896448"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02757"/>
    <dbReference type="eggNOG" id="KOG2356">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027091_4_0_1"/>
    <dbReference type="OMA" id="AWELECK"/>
    <dbReference type="OrthoDB" id="61116at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF4">
        <property type="entry name" value="N(6)-ADENINE-SPECIFIC METHYLTRANSFERASE METTL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="364" mass="42673" checksum="90E45F375A2E889D" modified="2013-05-29" version="1">MNQDIILETPSSHVLLDIPISINPLLLSKEPITKPFELPESESLHQSEFLITKYNYWKDEINEALQEMHYMRKNEKWTLEKKIITKEKIKFLETLENNIFLNSLCSYNILKSVKLLGGQLEDLELENNSYNWLDIYNRVVINSDYHTKSIKISNNIFHIPPKSSFILGNIEDNIDSLIKYIIKNGTFDIIIFDPPWKNKSSARKMAYSLSSNYILMKIPIQKLLSKKGIIGIWVTNKKSIHEFVENKLFKNWKMSKSGSWCWLKVTDTGEPIFNIQSFNRKPFEEILFAQFTNEPKKIEISKRIIAAVPDLHSRKPCLKNLLNSLIHDYKGCEFFSRNLIPGWFSIGNQTLKAQWDKWNTKYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP13</accession>
    <name>M7NP13_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 20</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mediator complex subunit 20</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MED20</name>
        <name evidence="5" type="ORF">PNEG_02777</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the Mediator complex subunit 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874808.1">
        <property type="nucleotide sequence ID" value="XM_007876617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP13"/>
    <dbReference type="STRING" id="1069680.M7NP13"/>
    <dbReference type="GeneID" id="19896466"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02777"/>
    <dbReference type="eggNOG" id="ENOG502SBIU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089405_0_0_1"/>
    <dbReference type="OMA" id="KKWIVQY"/>
    <dbReference type="OrthoDB" id="1854899at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013921">
        <property type="entry name" value="Mediator_Med20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08612">
        <property type="entry name" value="Med20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="179" mass="20644" checksum="AD21528CADE1494C" modified="2013-05-29" version="1">MPISGVFLCQDDTGMMLIESIQQRLQLFLAQVIGRWSMTYKLYTRYSKHLHMVSMSYYPGILFCKVNKTSIEVNGDFEQMIIKAKLWNMRQTIHLDGDMYEINDFIVRIASTNKGVIINIEYMSCDTIARGYITIQSFLIECLIPTFKNACIRSSYNEVALGDEKSNLTSGFQFIDVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP20</accession>
    <name>M7NP20_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein AF-9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02787</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874818.1">
        <property type="nucleotide sequence ID" value="XM_007876627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP20"/>
    <dbReference type="STRING" id="1069680.M7NP20"/>
    <dbReference type="GeneID" id="19896476"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02787"/>
    <dbReference type="eggNOG" id="KOG3149">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051385_2_1_1"/>
    <dbReference type="OMA" id="VKPYHNE"/>
    <dbReference type="OrthoDB" id="16041at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16908">
        <property type="entry name" value="YEATS_Yaf9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573:SF1">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YEATS" evidence="6">
        <location>
            <begin position="6"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="172" mass="19713" checksum="422CDB14558F3E3D" modified="2013-05-29" version="1">MAPISRVPKCQIIRPIVIGNIAMPLGDRKKPDSDHTHAWTVSVKGIYDEDLSYFIKKVVFKLHDTYPNATRTVDKSPFEVSETGWGEFDIAIRIYFVPEAAEKSISLFHRLKLHPYGPNSEIIREQGLSVTSYQYDEIIFNEPTEAMYDILTRHSRAVLPLDRSPTNLFSMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP56</accession>
    <name>M7NP56_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-galactose transporter homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01205</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873122.1">
        <property type="nucleotide sequence ID" value="XM_007874931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP56"/>
    <dbReference type="STRING" id="1069680.M7NP56"/>
    <dbReference type="GeneID" id="19894902"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01205"/>
    <dbReference type="eggNOG" id="KOG1581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036019_0_0_1"/>
    <dbReference type="OMA" id="CGAIGQV"/>
    <dbReference type="OrthoDB" id="1601at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005459">
        <property type="term" value="F:UDP-galactose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005460">
        <property type="term" value="F:UDP-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120112">
        <property type="term" value="P:UDP-glucose transmembrane transport into endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR10493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="319" mass="36104" checksum="AA1330D30E8A19A1" modified="2013-05-29" version="1">MGILICILGIYISFLLWSILQERITTRSYGKEIFNSVIILSIMQSFIAIIVSFIFMHFITKRSKKKIPSLSKSLFLKLILVALSSSLASPLGYASLKHINYPTLILGKSCKLLPVMAIHTIFYKTHFTYHKYLIVAIVTSGIAIFTLYDSQLSSKTNKQLSNDTWGLFLLSISLLLDGYTNSTQDQIFKAFSHVTGPWMMLYMNILSTVGTTLYLLCFTNELVTTLEFIKKYPSIISDILIYGCSGAIGQLFIFHTLEKYGSLILITITLTRKMLTLLLSLIWFNHKLTIGQWIGVVLVFYGASLEAYIKHTQLAKKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPD2</accession>
    <name>M7NPD2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873197.1">
        <property type="nucleotide sequence ID" value="XM_007875006.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPD2"/>
    <dbReference type="STRING" id="1069680.M7NPD2"/>
    <dbReference type="GeneID" id="19894970"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01273"/>
    <dbReference type="eggNOG" id="KOG0807">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_1_2_1"/>
    <dbReference type="OMA" id="MRVAVCQ"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110050">
        <property type="term" value="F:deaminated glutathione amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043605">
        <property type="term" value="P:amide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF27">
        <property type="entry name" value="DEAMINATED GLUTATHIONE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="253" mass="28399" checksum="FA2ED2DF5A638DEE" modified="2013-05-29" version="1">MNRAASVGAQVCFFPEASDFIGLNHEDSMKLTFSHEREVFINEFKEHVKLLKIHASVGVHEPILSKDLIANVCLWIDDEGNVIHKYQKLHLFSINAVDHQRMKESKYIEGGKSIVPPFKTPIGNVGLAICHDLRYPEMSIKLRNLGAEVITYPSAFISRTGADHWTTLLCARAIETQESISYVIAANQAGKHNETRESYGHSMIVDPWGIVLASCSTASREPSFCIADIDSSLVHKVRKELPLTRRNDVYPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPU8</accession>
    <name>M7NPU8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PIG-P domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02601</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874616.1">
        <property type="nucleotide sequence ID" value="XM_007876425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPU8"/>
    <dbReference type="STRING" id="1069680.M7NPU8"/>
    <dbReference type="GeneID" id="19896293"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02601"/>
    <dbReference type="eggNOG" id="KOG2257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081616_1_1_1"/>
    <dbReference type="OMA" id="KNIWNEG"/>
    <dbReference type="OrthoDB" id="690928at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052263">
        <property type="entry name" value="GPI_Anchor_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013717">
        <property type="entry name" value="PIG-P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08510">
        <property type="entry name" value="PIG-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="PIG-P" evidence="6">
        <location>
            <begin position="96"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="216" mass="24523" checksum="348DF05B009D5866" modified="2013-05-29" version="1">MKRTDGKRHSRHFFLKRSHSYNSILQPISMAQTSVFNPPLYGHPPGALVPLSFTSLFRTSSIQLSITPESSDNESLNRIQGNGFIKKYPLISKVPTYEYYGFVLYLGSSIVFGIYIIWSYFPISLLDVMGITYYPERWWSLALPSYFIITLIYIYFALLSYNIKVLTPKLNQMECITDSYAKVSSTVDIKSSTDAVIDLPIGKVSSLLYGDSGLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ26</accession>
    <name>M7NQ26_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PNEG_02547</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-serine + hexadecanoyl-CoA + H(+) = 3-oxosphinganine + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:14761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="EC" id="2.3.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="7"/>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874560.1">
        <property type="nucleotide sequence ID" value="XM_007876369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ26"/>
    <dbReference type="STRING" id="1069680.M7NQ26"/>
    <dbReference type="GeneID" id="19896239"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02547"/>
    <dbReference type="eggNOG" id="KOG1357">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015846_7_2_1"/>
    <dbReference type="OMA" id="QPRANGC"/>
    <dbReference type="OrthoDB" id="65434at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000047">
        <property type="entry name" value="serine palmitoyltransferase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF3">
        <property type="entry name" value="LD36009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="19">
        <location>
            <begin position="250"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMR09211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="665" mass="75388" checksum="4EAE0385A316F9E8" modified="2013-05-29" version="1">MARKRRNKESLDNTRDKTALQNKSLSLFNRGSKLISFLFPHRGFVQFFSNNGGYSNENNDVGMELRHTFSFDVPLSISGFSNVGFYRNIKKLKNDKKRSDFQLKFLTHMYKNEPRNDEVYQYAPLLDSSHLFVSQYPKGKPFPPIIEDEPSYYYLITTYFSYLILIILGHIRDFFGKRFKKQKYSHLRAHDGYAPLNSDFDNFYVRRLKMRINDCFSRPTTGVPGRMITLIERVSYDYNKTFNFTGNLIECLNFSSYNYLGFAQSNGPCADFVEEVIKKWKFSSCGARSDAGTLDLHVQCEALVAKFVGKPAASIYSMGFATNATLFSALVSKGCLIISDELNHSSIRFGARLSGASIRMFKHNNMEDLEKLLRECISQGQHRTHRPWKKILVIVEGLYSMEGTLCNLPGLISLKKKYKFYLYIDEAHSIGAIGPRGRGVCDYFSIDPSEVDILMGTFTKSFGASGGYIAADKHIIDKLRFLNAGSLFSEAMSPIVVGQIMSSINIILDETQNEGKNRLQRLAFNSRYLRLGLKRLGFIVYGHDDSPIVLILLYNPGKMPAFSRLMLERRIAVVVVGYPATSLVESRARFCVSAAHNKDDLDRLLTACDEVGDILQLKNSSGAAGENVGVRHLEYLLSGAYKVFHPPPRWALKDVIERGVDDVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ32</accession>
    <name>M7NQ32_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome quality control complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00950</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NEMF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872863.1">
        <property type="nucleotide sequence ID" value="XM_007874672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ32"/>
    <dbReference type="STRING" id="1069680.M7NQ32"/>
    <dbReference type="GeneID" id="19894648"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00950"/>
    <dbReference type="eggNOG" id="KOG2030">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003612_1_1_1"/>
    <dbReference type="OMA" id="MFLEFFA"/>
    <dbReference type="OrthoDB" id="207084at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.310.10:FF:000003">
        <property type="entry name" value="Zinc knuckle domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.310.10">
        <property type="entry name" value="ibrinogen binding protein from staphylococcus aureus domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021846">
        <property type="entry name" value="NFACT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051608">
        <property type="entry name" value="RQC_Subunit_NEMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239">
        <property type="entry name" value="NUCLEAR EXPORT MEDIATOR FACTOR NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239:SF6">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11923">
        <property type="entry name" value="NFACT-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05833">
        <property type="entry name" value="NFACT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="8">
        <location>
            <begin position="563"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="NFACT protein C-terminal" evidence="9">
        <location>
            <begin position="1004"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="824"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="884"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="365"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="839"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="861"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR10803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1124" mass="130293" checksum="88B4D772D4C78AC7" modified="2013-05-29" version="1">MKQRLNILDLKSVVSELQELLEFRLQNIYDISERIFQFKFSSSGRKEYLLVECGSRIHLTRYVRETAALPSQFCAKLRKHLKNRQLVSLKHICNDRIVYLGFGRSNETKELFKAQYYLIFEFYASGNIILADENMKILFLYRMVVFGDKRKQFSVGEIYHVSSSISQDEAEMTKDSLLSLIHTLKDKYITFSDDVSSKNIFSLSVCKKALKKGKTLKDFPLKKFISWELSGYGNSLIEHIIRDANIDPDMKLDEFYSNLESINMDDLLLSFKKADDIIRKCRENPVTGYIVEKKEPIKVKSENLNNIQAESTLDYIRIYLDFNPFIPKQFSDNPDYSIIAYDNYNSCIDMFFSSLESQKFDMKLKHQEDLAYRRLQATKEELQKKIDDLKKIQNISIQKAVAIEENLEIVDETIKAVNDCLLQSMDWNDIAKLIENEKEYGNPAAKIISLPLKLKLNTITIKLSSVRSDDAFEQGQDSNLFHIQKDRTETLDIDIKLSMNAWANARDYYDKKKLASIKEKKTVAASFKALKNAERKIKFDLKKSAGQEKKKIVPMRTLRWFEKFLWFISSDGYLVLGGRDSLQDKILIKDHFFENDIYVHADLKDASVVIIKNMHDSLFVPPSTLSQAGAFSISKSNAWTSKIVTSAWWVRYDQVIKHEDVEEQSLIEVFTIQGKKNFLPPSQLILGYGILWVVDEDSKVRRLKNKLSENNQNNSLINITLNQEATFVTEKIIDLSLNHEEKKVDITDTLDKSFIDNFEESSNQNNPLIYLKDTLIEKPLEEIENESKYNLEEYHEPLSLESKKIISDICTIYQKIEKKRMSFKERRDIKNMQMKTRKTKENPEKTKENPEKTKENPGKTKVNSGNTKDQNSESLNIKVGTEISNSKPLDTNKTKENGNLLSTNVRGKKGKIKKIMLKYADQDENDRILRMKLLGSNISSEKKDLKENKKSIVNKKHKANKDIKNTGGNNNYNNKKEIFQNNSEKKNNHLLVKENIKVPNNKEKNYEINLDAFVPFPLSDDVLVEAIPICAPYSSMAKYKYKIKLQPGSTKKGKAIRSIIAYWNALPIDLLCEDDEKVFPRERELIQSLKDSELLSPVYIPTLKTMMGKSKNDIFSKTNRRKHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQC7</accession>
    <name>M7NQC7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02248</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HTATSF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874235.1">
        <property type="nucleotide sequence ID" value="XM_007876044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQC7"/>
    <dbReference type="STRING" id="1069680.M7NQC7"/>
    <dbReference type="GeneID" id="19895941"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02248"/>
    <dbReference type="eggNOG" id="KOG1548">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026945_0_0_1"/>
    <dbReference type="OMA" id="DTDFRFG"/>
    <dbReference type="OrthoDB" id="10258585at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12281">
        <property type="entry name" value="RRM1_TatSF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000105">
        <property type="entry name" value="HIV Tat-specific factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000329">
        <property type="entry name" value="splicing factor U2AF-associated protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034393">
        <property type="entry name" value="TatSF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034392">
        <property type="entry name" value="TatSF1-like_RRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608:SF0">
        <property type="entry name" value="HIV TAT-SPECIFIC FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608">
        <property type="entry name" value="SPLICING FACTOR U2AF-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="56"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="310" mass="35573" checksum="22EF3C4E7812B666" modified="2013-05-29" version="1">MDEELIRLQQNAYSVEGVDETIPIDIRKKNRKRMDEKGKDEYLSSKKKNLGTSKNTAVYVSNLPPDVTEDEIKETFSKCGLISENIDTGKPRIKIYLNEQGEPKGDAVVVFFREESVKLAIQLLDDTYLRLEDRHGQKIKVQEADTSYKKSQNNPVKRSSNEKRKLQQKMKKLNNKISEWDDDTTTTSGRWSKVVILKHMFTLKELEEDITLIIDLKQDILEECSKIGNVTNIVLFDLEPDGVVSVRFSDEESALVCVKTMNGRYFGGKIVSAEIYDGKVRYRKSSNKNTDDADEQARLEKFGEWLKSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQF1</accession>
    <name>M7NQF1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873005.1">
        <property type="nucleotide sequence ID" value="XM_007874814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQF1"/>
    <dbReference type="GeneID" id="19894790"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01093"/>
    <dbReference type="HOGENOM" id="CLU_2623031_0_0_1"/>
    <dbReference type="OrthoDB" id="5341873at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="78" mass="9368" checksum="79513E7CEE8C9515" modified="2013-05-29" version="1">MKQTWLDRVLNQKFFLYTFVVVITLAVAVHIWSDKICSPDEWSDEMLREWLQKNHIFFEETDSRGVLIKKVKISLKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQS1</accession>
    <name>M7NQS1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872570.1">
        <property type="nucleotide sequence ID" value="XM_007874379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQS1"/>
    <dbReference type="GeneID" id="19894370"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00672"/>
    <dbReference type="HOGENOM" id="CLU_1687421_0_0_1"/>
    <dbReference type="OrthoDB" id="5382092at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="156" mass="18371" checksum="ABBB034FAFF2155C" modified="2013-05-29" version="1">MRSLLFFRYIVQRVQNVLWKISTKTTKYEEDIPLKKLSKKTAAPGTSSIKTPYYSTKAQKMNTFSLFGTSDRSQQCQSNVETSIFEYSYSFKKKKTYKKFKVILPAWKNDRHFNTFGLKHSVCEPSTSTDFCSRSIMQQLEAHNYQPHTFQLFRCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQX0</accession>
    <name>M7NQX0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1 6">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00715</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the PTH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1 6"/>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872615.1">
        <property type="nucleotide sequence ID" value="XM_007874424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQX0"/>
    <dbReference type="STRING" id="1069680.M7NQX0"/>
    <dbReference type="GeneID" id="19894413"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00715"/>
    <dbReference type="eggNOG" id="KOG2255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062456_2_2_1"/>
    <dbReference type="OMA" id="HDELQVP"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="entry name" value="Peptidyl-tRNA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224:SF1">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="Peptidyl-tRNA hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01195">
        <property type="entry name" value="PEPT_TRNA_HYDROL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR11118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="197" mass="22965" checksum="4F8C883B383ABEDF" modified="2013-05-29" version="1">MRELAEIQRILICSIGNPGEAYRLTRHNLGHYVLEEIRKYFGFSVFKKHLLVSGSYAEKRDTPFLLFRPDIYVNKSGIAIYRAWSKFCENLAIHERENRFLVVIHDDIEEKFGILKVKNCGKGRGHNGIKSCIESLGTESFIRFSIGLGRPPTRKSKDVINFVMQNLSEQELNYVHERTIPEVVKEIYKLIEKIKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7NR06</accession>
    <name>M7NR06_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872650.1">
        <property type="nucleotide sequence ID" value="XM_007874459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NR06"/>
    <dbReference type="STRING" id="1069680.M7NR06"/>
    <dbReference type="GeneID" id="19894447"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00749"/>
    <dbReference type="HOGENOM" id="CLU_1315877_0_0_1"/>
    <dbReference type="OrthoDB" id="5367324at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="209" mass="25391" checksum="694CEECAA5EABF97" modified="2013-05-29" version="1">MEKLPLPIKQYEGLLEQFRHELTPYLKRYEDVQEGEKNLSKETIYKLCDRMKIRSKINYFIEALEICHKRYPHVYDRKGLVAGMFIIMLFYLRGEKNINHEEKEEILFILGIDYMKQKELKYWIDFVKEDNDKYKWIDSIFEKKIDESMEIESAIESKPQCRAVSGIGMMIHPQIDFYGDKHYSEYLKWKKSILRRISLIKESRNRINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NR53</accession>
    <name>M7NR53_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01917</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873893.1">
        <property type="nucleotide sequence ID" value="XM_007875702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NR53"/>
    <dbReference type="STRING" id="1069680.M7NR53"/>
    <dbReference type="GeneID" id="19895611"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01917"/>
    <dbReference type="eggNOG" id="KOG0667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_785554_0_0_1"/>
    <dbReference type="OrthoDB" id="413582at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF130">
        <property type="entry name" value="SERINE_THREONINE PROTEIN KINASES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="353" mass="41047" checksum="A031459224EDE13A" modified="2013-05-29" version="1">MFIENECFHLVLEALDPLPIKLGRCMHLSTSGDPLHSPLACHIRHKTLRKIAKQILISLNILHNRANIIHADLKPENILRCYSDNPRSVKLKIIDFGNAIPLEAVEAYYVDFDLQSVYYRAPEVLLGLPFGPSIDIFSLGLILVELLFDSDELKKNSRPFLSTVETSRTSLAIEIARLLGKYPPRFKNAKFWKNDYYNIEINTSYLLKNRLRECNNPLLEDFIIKLLAIDDTERLTSKTALNHLWLFSDHYDLMHCSPIIKIDHVEPFSEKAFSIHNNEEIDIDYTNLSENHIFDDIYYKEKYKNTQDTNSFRTNEKSFIKENSTTPIKKPYCLDSWTINPTLEENQDEVLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRC0</accession>
    <name>M7NRC0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_01975</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873953.1">
        <property type="nucleotide sequence ID" value="XM_007875762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRC0"/>
    <dbReference type="STRING" id="1069680.M7NRC0"/>
    <dbReference type="GeneID" id="19895669"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01975"/>
    <dbReference type="eggNOG" id="KOG2445">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032441_1_1_1"/>
    <dbReference type="OMA" id="NAPTRRW"/>
    <dbReference type="OrthoDB" id="5566198at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061700">
        <property type="term" value="C:GATOR2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000578">
        <property type="entry name" value="Nucleoporin seh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF3">
        <property type="entry name" value="NUCLEOPORIN SEH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="280"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR09792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="338" mass="38717" checksum="C91BB67B417716D0" modified="2013-05-29" version="1">MEWKTIKTTHEDLIHDVSYDYYGRRLATCSSDLRVKVFDYDDITAEWIENDSWKSANAAILKVIWANPKVGQVIAICSIDRTVRIFEEQEHEAKNSGKRWHEKARLVDSRGAVLDIWFAPIHYGLKLASVSADAVIRIYEALSPNDLSQWTLMDDIILLSNPPPRDTESSFCLTWCPSRWDDQQLLVGAMNTVCIYRQNANNKWKAEESLDGHTDLVRDVTWGANMGRSYHIIATACKDGHVRIFKLTNKLNRFSNEDVIYNSEPIQAKKGYIIELVGDFDDHMAQVWRVSFNVTGTILSSAGDDGRIRLWKANYAGDYQCLTVISMEKTQKDDIIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRD8</accession>
    <name>M7NRD8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00311</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872185.1">
        <property type="nucleotide sequence ID" value="XM_007873994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRD8"/>
    <dbReference type="STRING" id="1069680.M7NRD8"/>
    <dbReference type="GeneID" id="19894009"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00311"/>
    <dbReference type="eggNOG" id="KOG2687">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_323157_0_0_1"/>
    <dbReference type="OMA" id="INHENTV"/>
    <dbReference type="OrthoDB" id="342281at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045119">
        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF8">
        <property type="entry name" value="KLAROID PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="8">
        <location>
            <begin position="694"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="90"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="895" mass="104109" checksum="E99DF5CA0342C67D" modified="2013-05-29" version="1">MFTQTPVGGRRVRNQRQWSKVITGDRPAAPLPSSGASPSFSYGSPSINPPDIPSLHDTTVGLASALRAAQKNTQRKDYINENITPLKQPKFLKQELSNTSPLYSPNPRNIERKKGSQRVLKKMDENLDSSDNHFQNDQLNMKTSGNNFKKNTDQDQNIKQNEKVSRYYLREHDSVDGGSRLSLNYDATNNSENLENFESRSYEEEELLYSQLNETDFKDFFDNYDSSIPEDYINTDSQEYLDDDYEKQANKILNFIHFCWFMITSLSRQFIFYCFNLLMWPITTLISLFSHIIKSILKITIRKVYTIFIILSIIFAITIPSLLEKNYIKLKWIYRPYSLSIYNHSNPQNMDELIQRLVNLEKTLKSYEITIQNIIQDKKNILKAIKEIDIKGHENSETTKLLKKEFNVFKNSFEKTKKEILNLNLQDDRKKSQITDLFHSFSFLQKNTSKCQSQFNDCKNSLASFNLEVSAIKKSVDCLYKEFNNFQMTFKNDSDDKYITDKIIKVIDSYLPPQLVVKINPKTKKIDISPEFWILLREIFPDRLEIDGVLKASFGKELNRDENASYLISWTNFLKNNEENMKTFIKTQTKEDLKKSEENGLIVSKTYFMTTLKENLKKIQNDLENDFTKMKEQINDRFKKIDYMFKNKTETDHLKYSKNENAFNKAIETLVKAALHKYSSDVLARPDFALYSSGARINPFLTSPTYLQRPTRFIPRLLSKIFWNIGCTWGYPPAMAINHENTVGMCWAFPGSSGQISIRLSETIFLTDITIEHVHSDIAHDISTAPRDIQFWAHIDHPDLQELVIQHTSPQSLNSIPPSKSYFLIATMTYNIFSTYSIQTFPIPTVIQQLNIPVKNVLFRILSNWGNDKFTCLYRIRVHGTKLTLNQTTTSNQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRG5</accession>
    <name>M7NRG5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872225.1">
        <property type="nucleotide sequence ID" value="XM_007874034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRG5"/>
    <dbReference type="STRING" id="1069680.M7NRG5"/>
    <dbReference type="GeneID" id="19894050"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00352"/>
    <dbReference type="HOGENOM" id="CLU_169171_1_0_1"/>
    <dbReference type="OrthoDB" id="5586401at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039870">
        <property type="entry name" value="Coa4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13639">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13639:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="71" mass="8644" checksum="2893A1B2542D7D14" modified="2013-05-29" version="1">MQLPFKSNNINEYDDDPWLKIVQSGKCAEEAEELQQCYFDKRDWRLCAEILNRFRQCWINKDKINMLIKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRK4</accession>
    <name>M7NRK4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit OST2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00395</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DAD/OST2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872269.1">
        <property type="nucleotide sequence ID" value="XM_007874078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRK4"/>
    <dbReference type="STRING" id="1069680.M7NRK4"/>
    <dbReference type="GeneID" id="19894093"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00395"/>
    <dbReference type="eggNOG" id="KOG1746">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111220_2_1_1"/>
    <dbReference type="OMA" id="HIILHIV"/>
    <dbReference type="OrthoDB" id="445566at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003038">
        <property type="entry name" value="DAD/Ost2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02109">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005588">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="132" mass="15213" checksum="A1820AA316AF5AA9" modified="2013-05-29" version="1">MKPNKIKFPKEIPSISKEKDSNTLLESFYEFFNNYQNNTDKSLKKIDYLIIFLVFSACIQLLYCILSGSYPFNSFLSGFISTVGQFVLTVSLRGQFNIKDEENNENISPERAFGDFVFSSLILHFFVITFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRM8</accession>
    <name>M7NRM8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Valine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="4">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PNEG_00421</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872299.1">
        <property type="nucleotide sequence ID" value="XM_007874108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRM8"/>
    <dbReference type="STRING" id="1069680.M7NRM8"/>
    <dbReference type="GeneID" id="19894119"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00421"/>
    <dbReference type="eggNOG" id="KOG0432">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_0_1_1"/>
    <dbReference type="OMA" id="RQWYIRN"/>
    <dbReference type="OrthoDB" id="629407at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00817">
        <property type="entry name" value="ValRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000009">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000020">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000078">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000005">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="entry name" value="Valyl-tRNA synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004349">
        <property type="entry name" value="PRK05729.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF109">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14 18" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="16">
        <location>
            <begin position="66"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="17">
        <location>
            <begin position="733"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="941"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMR11398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1012" mass="116651" checksum="BC4A1894F5951CC4" modified="2013-05-29" version="1">MTVCMGSFIDKHKENLNEKQKKKKKHDFTIGEEYKEITPLGQKKLLQDLELPALKNYNPIAVESAWYEWWMQEGFHLPEFGPDGNCKPEGVFVIPIPPPNITGILHIGHALTVSIQDSLIRWQRMKNKTVLFLPGFDHAGLSTQSVVEKKLWAQEKKTRHDFSREDFVNLVVKWKEDYSSKIKNQLMRLGGSYDWSREAYTIDENLSNAVLEHFVRLHEDGIIYRANKIVNWCTFLNTTLSNLEVDQIELSGSTLLDVPGYDKPIEFGTLTYFAYEIYGSSERIVVATTRPETILGDTAIAVHPDDQRYKRFHGKMAKHPFIDRLLPIIVDSISVDMTFGTGAVKITPAHDINDYEIGKRHNLNFINILNPDGTMNENAGCWKGMKRYDVRVSIVEKLKEKGLFVDTKDNPMIVPICSKSKDVIEPVIKPQWWVDQKAMSIDALNAVKNGEIKINPKTSERDFYRWMENVQDWCISRQLWWGHRIPAYFVRIEGRDQDSSDNKWWVSGQNKEIAQKKAEKLFPGENFILEQDEDVLDTWFSSCLWPFSTLGWPKETEDLKNFYPMSLLETGWDILFFWVARMIMVGIKLTGKVPFKEVFCHSLVRDSQGRKMSKSLGNIVDPIDVIEGISLEDMNKKLATGNLDKKELEIAKKNQKKNFPNGIPQCGTDALRFTLCAYTTGGHDINLDILRVEGYRKFCNKIYNATKYALLKLGDNFVPRIKEDKSGHESLVERWILHKYTKTAQSLNIALEERNFYNATNVIYNFWLYEFCDIYIENSKIIIDKGDIEEKKSAMNTLYTCLDGALRMIHPFMPFITEELWQRLPRRPNDVTVSIVKSAFPSYNPEFDDIDADISYSLIFSIIQTSRSLMAEYNIRINSQLYFQVNDHVINILESQKNAILSLIKGSGSIIILKNNELPPEGCVTIVINADCTVFLLVKGYVDFDIEIEKARKKIAKLELSISQIKKQMKVEDYHTKVPESVKSANKDKCSILESEIKALEKIILDFENLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRR8</accession>
    <name>M7NRR8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00462</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872344.1">
        <property type="nucleotide sequence ID" value="XM_007874153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRR8"/>
    <dbReference type="STRING" id="1069680.M7NRR8"/>
    <dbReference type="GeneID" id="19894160"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00462"/>
    <dbReference type="eggNOG" id="KOG1589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099502_1_2_1"/>
    <dbReference type="OMA" id="FWAPIVK"/>
    <dbReference type="OrthoDB" id="869189at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="111" mass="12494" checksum="1924CBA49B164B6D" modified="2013-05-29" version="1">MASFVSTARNKFIYLLNHPSGLKTVHFWAPTMKWGLVLAGIGDLKRSSDKLSVSQNMALTLTGSIWTRWSMVIKPKNYLLATVNLFLAITGSVQLLRIYFYRQGLERAGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRV9</accession>
    <name>M7NRV9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_00502</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872389.1">
        <property type="nucleotide sequence ID" value="XM_007874198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRV9"/>
    <dbReference type="GeneID" id="19894200"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00502"/>
    <dbReference type="HOGENOM" id="CLU_931033_0_0_1"/>
    <dbReference type="OrthoDB" id="5425097at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082240" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="24"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR11488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="299" mass="32489" checksum="4B56A5D641B89F7F" modified="2013-05-29" version="1">MGFLFVTFLFAILTLINAYKVLLPKPGDKWEPGLHQVTWEAVDDTSTVNVYLHRNNDNPPFYLLLAAKVPLKDGKADVPIPYNVIPGSEYTILLTSLNPYDVYTSSGGFEITEAKDGLKGVCVDYLKDDGSSTIGPIPGDTRPVTTSLLPPSPTPPSPAPPAPTPAPPAPTPPSPEPPAPAPPEGEVENCDECDECEECGECEPGEGCDCDADDHGDDDYDKDEDHGHSHDDDDDDDDDHENDHDDDDDDDDHGHSHDDDDDGHDHGEDKNKLANIGSTNIVTRFWLTMMATISTILFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NS41</accession>
    <name>M7NS41_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Pheromone-regulated membrane protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00017</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871868.1">
        <property type="nucleotide sequence ID" value="XM_007873677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NS41"/>
    <dbReference type="STRING" id="1069680.M7NS41"/>
    <dbReference type="GeneID" id="19893715"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00017"/>
    <dbReference type="eggNOG" id="ENOG502QPMM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007078_2_2_1"/>
    <dbReference type="OMA" id="FAHGCAS"/>
    <dbReference type="OrthoDB" id="413008at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="530"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="562"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="602"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="642"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="665"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="695"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="774"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="8">
        <location>
            <begin position="375"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/Serine exporter ThrE" evidence="9">
        <location>
            <begin position="646"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="813" mass="89538" checksum="E7897E252A450BD6" modified="2013-05-29" version="1">MSEQAGNTSSDAGDIPDESCAEDLSKRRQKRNIHRVRFDAKEDLENMESVIIKESTHISEEATQSSSSQRHKRVSSFYIQEEVETSALDSKEHLALPGETESSPLSPVLDSFESSQRLGISPLSLYTSQLLESQQTKIPSVQLLDPPHRVSSSPFLSGESPSTFSVPEEFEQCVPKPSNKQASAASSKKKTGKKRGREIYSLTKYAYDLVRSHLRGESYRQKKILKGSDISDDSTRIPGEDTTQASGFRGGVLSHLLKLYNSDNIHFNRQNINITPPGTGRSTPKWHSKSTNSSSTSLSALLATSSATVALPGLLNIHRDDSGSGLSKSSRPPYKLRKHSSGLANAIKHSLSRSRLEDEIRITIHLADVLQRQKFILRLCHALMLYGSPTHRLEECMKLTSRVLEIDGQFLYIPGCMIISFGDLITHTSDMHVVRVNQGLDIGKLQETHFIYKQVIHDLIGVEEAMKNLDEVINRKQYYKNWVVILFYGFASALVGPFAFNASWFDMPISFLLGTILGLLRVVVTPRSFMYANAFEISATIITSFLARAFGSIPDRKNQGKYIFCFASMAESSIALILPGYLVLCGSLELQTKNIVAGSVRLFYAIIYSLFLGFGITIGSVIYGSMDRKASNETYCQSNIDILYRFISVPIFTACILVVNQAKPQQFPVAVIIAGAGYIVNFFSSKRFGASQVSNAIGAFVIGCLGNIYSRIGHDLAFTVVLPAIFVQIPSGLAAQRGVYIGIGESNEIFAHNSSTDYNISNVGVEHSSSPNSLSFGIVMIQIAIAITVGLFFSSILIYSFGGMRKRSALFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M7NS54</accession>
    <name>M7NS54_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871883.1">
        <property type="nucleotide sequence ID" value="XM_007873692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NS54"/>
    <dbReference type="STRING" id="1069680.M7NS54"/>
    <dbReference type="GeneID" id="19893730"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00032"/>
    <dbReference type="eggNOG" id="ENOG502S9QD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058478_1_0_1"/>
    <dbReference type="OMA" id="KQHNRIV"/>
    <dbReference type="OrthoDB" id="21214at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031511">
        <property type="term" value="C:Mis6-Sim4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025207">
        <property type="entry name" value="Sim4_Fta4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42040">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT FTA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42040:SF1">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT FTA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13093">
        <property type="entry name" value="FTA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="216" mass="25298" checksum="A715C224A42B2C53" modified="2013-05-29" version="1">MDSIYLHKKAFIESQIRLLSRPLDPPPNWRENAKLDEDGNELSETAVIHAIYCLNVLLRKQYRIIFSSQAIRHVSEQIDRLYHSPLEISLIEPVECDFQSLENIERLPSVWPSDDEKSSEKYTNIRARLISLTVALSHLRQKYAFYESIESSLRQLRQQTDLSSRLSVELERTKKLTAKIRQKLKKSNIKVKPQTQETVPESFMEFCSRIKPDIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NS91</accession>
    <name>M7NS91_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Swi5-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01744</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWI5/SAE3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873708.1">
        <property type="nucleotide sequence ID" value="XM_007875517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NS91"/>
    <dbReference type="STRING" id="1069680.M7NS91"/>
    <dbReference type="GeneID" id="19895438"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01744"/>
    <dbReference type="eggNOG" id="ENOG502SBQH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106110_3_1_1"/>
    <dbReference type="OMA" id="TTVKRHI"/>
    <dbReference type="OrthoDB" id="255837at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032798">
        <property type="term" value="C:Swi5-Sfr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034974">
        <property type="term" value="C:Swi5-Swi2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007534">
        <property type="term" value="P:gene conversion at mating-type locus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010772">
        <property type="term" value="P:meiotic DNA recombinase assembly involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000708">
        <property type="term" value="P:meiotic strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010760">
        <property type="entry name" value="DNA-repair_Swi5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07061">
        <property type="entry name" value="Swi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="10373" checksum="B3B51680EB05E76C" modified="2013-05-29" version="1">MMECDSLNLKTLENKVLSLEARLNELTEKQKTLQATLKNPDATSTVKQHIVLLHTYNEIRDVALGLMGKIADQERCRVVEVMDRFGITKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSE3</accession>
    <name>M7NSE3_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01795</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873763.1">
        <property type="nucleotide sequence ID" value="XM_007875572.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NSE3"/>
    <dbReference type="GeneID" id="19895489"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01795"/>
    <dbReference type="eggNOG" id="KOG1786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1788">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000175_2_0_1"/>
    <dbReference type="OMA" id="EMSNFHY"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000002">
        <property type="entry name" value="WD repeat and FYVE domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056252">
        <property type="entry name" value="Alfy-like_Arm-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051944">
        <property type="entry name" value="BEACH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108:SF4">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23295">
        <property type="entry name" value="Arm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="10">
        <location>
            <begin position="1681"/>
            <end position="1814"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="9">
        <location>
            <begin position="1850"/>
            <end position="2145"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="2285"/>
            <end position="2326"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="8">
        <location>
            <begin position="2482"/>
            <end position="2536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR10041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="2538" mass="297983" checksum="73D668FD3B1261F6" modified="2013-05-29" version="1">MFNTLLSQLFQMNNAIDQIFVLSQIRQLIINNQESMSFFRKCQGFEKVLNFLYMFFLNNENENTQKNLQYKDYKQSIQVICSVFTLLSTAVSWSPFNSYHFFHYCDISSFILKTTLLQNEPETLIGMLFSFALNDESFQSSFRSIKEQLNIKSYTNKKLQKQTFDKLEKLIKEKFSEKDIIINPGILPLILLVQKNFKLSWHRLSILLTFNSLLGNCISKINLVAFTNSEIPSIIIKRLFNNDSLILDPMEKKILLQLIDKLCQNGLPTKDVFFLIQKFSKDLTKNEELTSFLLHLFSQNQSPSHIQFNLSLHGYSYIEFSSLHKSFPPLNGYSMLFWIRFDMFDETLDTDILSIVDNQKKYICKLFIEKNSKNLLFQTSLKNRTKFSFYRFKEGQWYHIALIHEKQKAMTLSKLSFSVNGLHIESIKCPYPIINKDKSPIRLFLGTPQELCTRYGQDKSLVKWSLSSFLIIEDVLNEDIIDLYYHIGPYYDKDYQNTSRNLMKNSSTILNIPLGKKNTKNEKIINMDILKNENITSILYNKVLFYICNDSILDISISNKWDDSEKINKKIMQIAPKKIDNNLIILNKAVPFSNNYIINRERIGWFIGNPINVIVNNTEDSIFYIGGPTLGLKLIEISKTPNDVICATKLTFSFIKNNRRNLEHMEKNHGYEILAKILKNKENIHNICLLNSILIFIGCKELDSKNSIILNPLAYKFLILDFEIWKKADEKTIKLYMQHFLSLVLKSSYAKFNIKCLDKMHIIKRIIMILKLDYISENIFPLFLITFKTLIEIYFTPKIIKMLLTYIIYALYKEPMKTKHKTTEPSISHLFKDKIGPNSLNKKDLNHNSPLYKKAIYILEMLSDILCNTQNRSFIEKFSKVITAKWLLLLLSNKDSRCVICSFKIISQLMILKGTSYISKFLPKTHYFLLIKLYLKKWWNNINIWKIAFCLFFGTDILNIKGNTDIKNFDEFLRLLLNKNKNVTEIYCFEMYDVILAMLESGAHNLKLFQTYINSTKDDMSIYFSSINVTRRRSNSLSAIYSKINKNNFKHNHIHNFKKTNYYEGFDILLYVIRFIKNMYLSIRCFKEHILSPYFIEKLLYIVCPLIFTKDHIGTKAILNSRNSFHISSKNIIIDTLPFENDHIPTLWKLDTINNSFSKCFIETISDKNISLIYLKSTITKKNKSSTFKSKLLKSSELDYEYNIASIYEILLQLLVTNVIDSIIISSKKYVLKLNIQIPLCFFGNQIYIESYILYTTLIKLHKIIQSQLDKLNEISVLSNICIFSKDCLNCALKGHFFICEHLLEFLIFILEHIHKISIKKQKKIYGQFFINIQQCFHNVLFLKLSTLKNYNEKKKIQNFIEKIMRYNYVIFYPSTDIHEFITYFCYWLYILLSNKSYNLRVMSINIWKLIIQQKFHEISSIFDQSIPSDYNIADTFLNIRNLDLKYFLSWINENKYILDNTFFKYLNTSWDNYLENQLKNWKEIILLDEQARNDRLSIQENRIIQISDIFVKHESILSNWHKNLILLQHKKIEKYIQDQIDLDKFLNSVWSKIVNNLTEDHCIFESNREKKWKLDFTEGRSRMRKKMKSDTNQSLIIQSEVQQKNPIDLYKAEETDERNINENNREILKISHDFKNSTDQINIEKAISSTIQNLNNENPNEKTNDLFKDDKSRKILRNLEYGDYIIEIHNISRINGLNAYEGILFLGKNNLYLMDNYFQKSNGEITTIWDPTVENERDLYIQLLSGKDISKKKTAPFQSEHKTRKWPFDQIVSVYRRKFLFRDVGLELFFADGQSYLITLPIKKREHVYNKLLSKLSQINYRFSKDFLINSEFTDTIKSQTSITKFSSRIINMFNSTHPSLKKWKEGKISNFHYLMIINTLTGRTYNDLTQYPIFPWVLADYTSEELDLTNPKSFRDFSKPMGAQNPLRRSEFEKRFKSFQEIQDSSQPPFHYGTHYSSAMIVCSYLIRLKPFVDSYLLLQGGSFDHADRLFYSIEKAWLSSSQENMADVRELIPEFFYLPEFLINSNNYKFGKKQGSNEIIDSVILPPWAKGDPKLFIKKHREALECDYVSEHLNEWIDLIFGFKQQGELAVKATNIFHHLSYQGSIDIDKIQDPIEKIATIGIIYNFGQTPNQIFQQPHPKRTCNSKKYITATKIPYLGKYEKNISSLIQAIMHLQESDFSIKTIIYLEDLDKIIGCSSNCMYMVPNINICLQWDIIGSDIEFYNRENKKIFKSFHKLHLKQVTCACFIEPYTLITGSNDCIIYIWSIIQGKTINLKLKNYLRGHFKPIISLDSSKSFSIIVSGSEDGLVIEWDLNRACYVRTLEKSNNPIQCISINDANGDIAACSEMTISIWTINGDLLLRQNIGFSQNDIIFSCKFYEGINYEWLECDLIFTGHNFGIVQIWNISWKTKNGKLIRELINIKTLQHYDYIKDSLLVSKITALYPSGKTRSLFTGDNLGNVYIWNLPDTVYKSHYLSSEEYNNCFICKTAFAIIDRKYNCHPCGALLCSNCIHQHSKIGSTKLCINCISSLVFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSQ6</accession>
    <name>M7NSQ6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_01553</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873502.1">
        <property type="nucleotide sequence ID" value="XM_007875311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSQ6"/>
    <dbReference type="STRING" id="1069680.M7NSQ6"/>
    <dbReference type="GeneID" id="19895248"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01553"/>
    <dbReference type="eggNOG" id="KOG2307">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1086323_0_0_1"/>
    <dbReference type="OMA" id="YKLMGED"/>
    <dbReference type="OrthoDB" id="332281at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="9">
        <location>
            <begin position="28"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR10292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="256" mass="30404" checksum="8B97F81E834EFED9" modified="2013-05-29" version="1">MSNEDFFKDSDQENTLKDLLSFDLCKELNKEALLKEDFSVDDFLKKIYKFHTLEDLQIKLKEVLKSTEKEIFTLIYNEYNNFFKITCDILENENKIIDLLVRLTKFKNEVQEIYKVIQQNVVNMDEELHKKKELYRRKVLATNLLNVNMMIEDMENLLCTDSEKFDGADIIILQQAAKSYISLKYYSSLVPSQHPFIEKRKEKIQNVQNNFFNCLASALHKYRENALQIENLLKVLQIYREIDASAEACHQLYKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTL6</accession>
    <name>M7NTL6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_01160</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of a tri-snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNUT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873075.1">
        <property type="nucleotide sequence ID" value="XM_007874884.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTL6"/>
    <dbReference type="STRING" id="1069680.M7NTL6"/>
    <dbReference type="GeneID" id="19894857"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01160"/>
    <dbReference type="eggNOG" id="KOG3263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075596_2_1_1"/>
    <dbReference type="OMA" id="HINMESP"/>
    <dbReference type="OrthoDB" id="21368at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013957">
        <property type="entry name" value="SNRNP27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077">
        <property type="entry name" value="U4/U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077:SF1">
        <property type="entry name" value="U4_U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08648">
        <property type="entry name" value="SNRNP27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein" evidence="9">
        <location>
            <begin position="126"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR10446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="184" mass="21596" checksum="49F6F0055CC81496" modified="2013-05-29" version="1">MSRKYSLKDDQRWERSPSNIRRSRSRSPYSDSKHICLKDKSYERKRSKERYSSRSGRNYTVSHRSDNNPHVRRRSISPLSRYSVSPQGYKNTNRSSELKDDSVSSKHLKSDIKTLNNLKVDDIDNETSQMEAILGFSGFKTTHQQKVEGNDVGIVYKVKPTKYRQYMNRRGGFNRPLDTDNPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTM4</accession>
    <name>M7NTM4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamyl-tRNA amidotransferase complex subunit Gta3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873261.1">
        <property type="nucleotide sequence ID" value="XM_007875070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTM4"/>
    <dbReference type="GeneID" id="19895030"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01333"/>
    <dbReference type="HOGENOM" id="CLU_1704984_0_0_1"/>
    <dbReference type="OrthoDB" id="5394539at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049545">
        <property type="entry name" value="Gta3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20978">
        <property type="entry name" value="Gta3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="Glu-tRNAGln amidotransferase C subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl-tRNA amidotransferase complex subunit Gta3" evidence="1">
        <location>
            <begin position="57"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="154" mass="18209" checksum="679DBBB0D11982A7" modified="2013-05-29" version="1">MYNFFSRFKRAFLGRNSDILVNIQREIKTLKDITEHLDIGIPSTDLLLYYIRNQKVEKLSDKTLKHLCKLSFLSFPKDDKKEKLIEKISMNIDFVKSIKDVDVKYVKRLVSVRKDGPILLTYENLSNKTEEPCEWNVFGLTKNREGNFFVLKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTP4</accession>
    <name>M7NTP4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">5-aminolevulinate synthase</fullName>
            <ecNumber evidence="11">2.3.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">5-aminolevulinic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Delta-ALA synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Delta-aminolevulinate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_01347</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="2.3.1.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.37" evidence="11"/>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873276.1">
        <property type="nucleotide sequence ID" value="XM_007875085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTP4"/>
    <dbReference type="STRING" id="1069680.M7NTP4"/>
    <dbReference type="GeneID" id="19895044"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01347"/>
    <dbReference type="eggNOG" id="KOG1360">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015846_6_0_1"/>
    <dbReference type="OMA" id="DQFFRNK"/>
    <dbReference type="OrthoDB" id="10263824at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003870">
        <property type="term" value="F:5-aminolevulinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902117">
        <property type="term" value="P:positive regulation of organelle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000006">
        <property type="entry name" value="5-aminolevulinate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010961">
        <property type="entry name" value="4pyrrol_synth_NH2levulA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01821">
        <property type="entry name" value="5aminolev_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF102">
        <property type="entry name" value="2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="12">
        <location>
            <begin position="130"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU910713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR10647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="517" mass="57992" checksum="C667E3F8B684D73B" modified="2013-05-29" version="1">MTAGGITELQALGYACPVMGNVMKNIEARSYATASRTNNAKMDVLENIHAKAGVFGSISDGKSEVCPYGKAILNAPHEQVLTNQFFDYEEWFSSELDKKRRDKSYRYFNNINRLANEAPYAHTNDLNKRVTVWCSNDYLNMSKNKQVIDSIRHTLHVYGAGAGGTRNISGHNQHVEHLEATLAHLHEKDASLVFSSCYVANDACISTLGSRIPDCIIFSDASNHASIIQGIRNSRAKKVIFKHNDLKDLESKLMAIPLYIPKIICFESIYSMCGSVAPIKEICDLAEKYGALTFLDEVHAVGMYGKHGAGVAEHIGQMSRIDIISGTLAKAYGCVGGYISSSKNIIDVIRSLAPGFIFTTALPPHVMEGARVSVEYQKRTQRDRILQQIHTRHLKKALKDARLPVLPNPSHIIPLMVGDSQTCKEISDELLLKYDIYIQPINYPTVPVNMERLRIIPTPAHTIEFQKKLVTALKQIWDDRLLKKIDDWDMESLGSFTEELWTDEQLRFYDTENILGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NU23</accession>
    <name>M7NU23_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873250.1">
        <property type="nucleotide sequence ID" value="XM_007875059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NU23"/>
    <dbReference type="STRING" id="1069680.M7NU23"/>
    <dbReference type="GeneID" id="19895021"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01324"/>
    <dbReference type="eggNOG" id="KOG0797">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006974_0_1_1"/>
    <dbReference type="OMA" id="AYKCMWA"/>
    <dbReference type="OrthoDB" id="5572108at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10206">
        <property type="entry name" value="ASKHA_NBD_Arp8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="572" mass="66183" checksum="7843D078B5F10E6C" modified="2013-05-29" version="1">MPPRKKGATQLDEQRRNEFMRFTTFPVIQPINQKNYYTEYLKREDQILMYRASDKTWSEETDVKIETRRSDGEEASEEEEEKHGNDAKVLVIHPGSMYLRIGLASDAFPQTIPNVIAHRHGSMRSRHEADAKLINEEKERIHFEEILQEMDLALKTRLRLSKRRTQSNTRELVIAYNREVLPEVMVEPVNQDEWVDVNEKPASLVGHKALKIPPHASADYTLFWPIRYRVLNKNDYISSRQCIDDIAAIFESALATLGMQRVDWMPLAVVLVIPDAYDKVYVETMLDILIRELQFSKVCVLQESVCTAFGAGLSAACIIDVGAQTTSIACVEEGICLPESRLQLCYGGEDVTRFFVRLLLRNHFPYAIDLRKIQDWRLADTLKIRHCTANENNTAIQLLHFFHGEPGNTKRFQFKVYDEPVLAAMSYFFPKIFENESKNSEKSVYNTNITHEETNEWKPLDEAIVESITRACEHAPSDERQKTMYRSLLLVGGGYAFPGFVHVLEDKLQIKQPTIQFLSPPRDMDPQILTWKGASVFSQLKISQDFWIKQKEWDLLGLRCLQYRSLGYFWNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUB2</accession>
    <name>M7NUB2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="3">3.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3-hydroxyisobutyryl-coenzyme A hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01024</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872937.1">
        <property type="nucleotide sequence ID" value="XM_007874746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUB2"/>
    <dbReference type="STRING" id="1069680.M7NUB2"/>
    <dbReference type="GeneID" id="19894722"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01024"/>
    <dbReference type="eggNOG" id="KOG1684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_22_0_1"/>
    <dbReference type="OMA" id="AYRNNEH"/>
    <dbReference type="OrthoDB" id="1737613at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000026">
        <property type="entry name" value="3-hydroxyisobutyryl-CoA hydrolase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="7">
        <location>
            <begin position="55"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="483" mass="55246" checksum="21F9FBC396AD4741" modified="2013-05-29" version="1">MKTTVFSSKTNSFSFKFMINFLVFTRKFSRAKMNFPMIETESNKEVLFDSYFGLRMITLNRPKKLNALNMIMTKNIYEKLIEWKRSSLAKIILLRGINNRALSAGGDVVAIAELCRLDMEKGYKMAMEYFELEYRLDYLIATFKEKPYVSLMDGITMGGGAGLSVHAPFRVATENTVFAMPETDIGFFPDAGLSFFLSRMDGEVGKYLGMTSERLYGFDTLISGIATHYVPSERLDSLIARLSELDTNDCSSKDYFNVVDRAIDEFSGEPPRNYKYRLGGETREAIDRCFKYKKIENVFKALKKEGTEWANSTIDTLNRRSPTSIKVALREIQEAKKWNILQAFNNELNITSYLLKTHDFIEGIEAKLVKKPSVKPVWKPSIISEVSDKLVDTFFKSCKDSPQLNISGDLISVQYQDYPYNYGLPTEIDLEKSIRNCISNNVPVNSIRDVVFDIFFKVSPNKPGLSIKLDDILFRKRFGQLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUM7</accession>
    <name>M7NUM7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_00612</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872510.1">
        <property type="nucleotide sequence ID" value="XM_007874319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUM7"/>
    <dbReference type="STRING" id="1069680.M7NUM7"/>
    <dbReference type="GeneID" id="19894310"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00612"/>
    <dbReference type="eggNOG" id="KOG1363">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020031_2_0_1"/>
    <dbReference type="OMA" id="VYAFVEC"/>
    <dbReference type="OrthoDB" id="1026733at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="4">
        <location>
            <begin position="375"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="323"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR11012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="477" mass="55474" checksum="BFF7F848F8F569CD" modified="2013-05-29" version="1">MDNRNLTQEEINILQSFELITEINNSKISLEILENYEWNLEKAISSIYEENPQLQTSPSGNPMNDSTDINYPHDLSQLSPEILNTNTSPIISSIFTLIVLPLSILYKAISKTMYFFTRMFPFLSKFMGFSPPNLVTGQFQKFNSKNTSEKFIRKFEQEHGVDHVPFFEGGYVEALEVAKKDLMFFMVILQSDLHDDTYSFNRITLTNENLIGFIANNNILVWAGSVHEPEAFQVSNNLNCTRFPFIAIGISHLHSSNTSNVSSLARIEGFILPNDMIATLETYVVQHLPTIRRLRSTREEQLIARQIRTQQDNAYEASLAIDRERMLQRKEEEKHRMEIEKKRQKELNDARILEANKSQWKIWRASKLFPEPTSDSSQIAKVSLRLQNGERIVRKFDANVSIEEIYAFIECYDINTEELHEPIEKPLNYVHKFNFQLVSPMPRQIIRYDTKQKILEEKNLYPSGNIIVENLDEDKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NV16</accession>
    <name>M7NV16_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00738</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872639.1">
        <property type="nucleotide sequence ID" value="XM_007874448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NV16"/>
    <dbReference type="STRING" id="1069680.M7NV16"/>
    <dbReference type="GeneID" id="19894436"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00738"/>
    <dbReference type="eggNOG" id="KOG2061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034893_2_0_1"/>
    <dbReference type="OMA" id="TVYVFCC"/>
    <dbReference type="OrthoDB" id="443682at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12298">
        <property type="entry name" value="PCDC2 PROGRAMMED CELL DEATH PROTEIN 2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12298:SF4">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="115"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR11142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="332" mass="38504" checksum="7388852D9ECE5C77" modified="2013-05-29" version="1">MKIWLGFLEKFYSEDDSYLCDPTVSKIGGRPIWINSKVIPKSQDLQCGICKKMMRLLLQLYCPEIESPFSYHRVIYVFVCEDGSCQRSGFSKSFKVIRVQKDNSKDIDIETSHLCVVCNILGTYICSKCKTTRYCSKQHQKIHWELALHKNYCGTSEGSKWPVLKKAWWNEMEIICEVEPEETLPIGNELIQHKYGPNAIPDKFEKFSEIKGDKTFFQFQKRLGRAPTQILRYIRAESNDTEDSPILWISSEGQLNNSEIAKCPCGEKRTIEFQIMPTLLSFLNIDYSEKYSLDWGVLNVYTCEKNCMLANNNVCQELLWRQEISNEIISGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M7NV34</accession>
    <name>M7NV34_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR10986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872484.1">
        <property type="nucleotide sequence ID" value="XM_007874293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NV34"/>
    <dbReference type="GeneID" id="19894287"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00589"/>
    <dbReference type="HOGENOM" id="CLU_1050203_0_0_1"/>
    <dbReference type="OrthoDB" id="5361617at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="1">
        <location>
            <begin position="51"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="265" mass="30195" checksum="1220AB074E828B29" modified="2013-05-29" version="1">MEENSEERAKRLAQLSEKLAVARLEHEVKSLETEVLNILKSSLSKKAFILCVFDASALIDSLKIIKSWIGTKSVKIVIPFSALEELDRLKKGTDIINVNARSVIRFLERFSNNTPDEWTIRMQKPSETVDWLECVPLFSLNSESEGILLKHIMKQKGSCLIESKYTQTITAHKTPRGLRSLICFMVYLQKNVGAEFSSCQLITHNPITIAWAKLFSIKTFTVAQLTSDIALNMKEHIDSKKKYNSLKKRFKSNSAKLSLLYPEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NV41</accession>
    <name>M7NV41_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS5m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">28S ribosomal protein S5, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_00757</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872659.1">
        <property type="nucleotide sequence ID" value="XM_007874468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NV41"/>
    <dbReference type="STRING" id="1069680.M7NV41"/>
    <dbReference type="GeneID" id="19894455"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00757"/>
    <dbReference type="eggNOG" id="KOG2646">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037994_0_0_1"/>
    <dbReference type="OrthoDB" id="309483at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000022">
        <property type="entry name" value="28S ribosomal protein S5, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000002">
        <property type="entry name" value="30S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="10">
        <location>
            <begin position="152"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR11162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="314" mass="36105" checksum="B9D9FDD63388BBE6" modified="2013-05-29" version="1">MFPTNIYMSRLSLWLGPFKYVCSIKKCYFSSFFGLNINKNKNITLKKEYMDKNILSVIKSHDYSELKNQKLRRTQLHIPYVTDFLIKDPFLDKESDFLNNKTSNLPETSLDTSEEYDLAPYLPKIESIFLKENDPEYLSMITGMSPWEIKKLIQKPLVIRRVVNQTRKGKISSMYSLAIVGNGSGMIGLGEGKSKALRTAIKKACLQAMKNMHYIPRYENRTIYGNVRYKFHAVLLELRSRPRGFGIRANHFIHEICRCIGIKDLSAKVRGSCTGMNVVKATLEALKTQVLPEDIARARGKKVVDVMQTYYSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVI0</accession>
    <name>M7NVI0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_00747</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Tango6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872648.1">
        <property type="nucleotide sequence ID" value="XM_007874457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVI0"/>
    <dbReference type="STRING" id="1069680.M7NVI0"/>
    <dbReference type="GeneID" id="19894445"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00747"/>
    <dbReference type="eggNOG" id="KOG4653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006300_1_0_1"/>
    <dbReference type="OMA" id="QVATLIC"/>
    <dbReference type="OrthoDB" id="39591at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057407">
        <property type="entry name" value="HEAT_TANGO6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019451">
        <property type="entry name" value="Rtp1_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039600">
        <property type="entry name" value="TANGO6/Rtp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959:SF1">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23565">
        <property type="entry name" value="ARM_TANGO6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10363">
        <property type="entry name" value="RTP1_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="TANGO6 HEAT repeat" evidence="4">
        <location>
            <begin position="244"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="3">
        <location>
            <begin position="666"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR11151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="924" mass="106976" checksum="A7170135FAF2FC19" modified="2013-05-29" version="1">MDQIFQKKLTEIGFFLDKIVHSMNVINQKTVNSENIELIEDEKKQNSIELFNEAEKLLIFLVEVSNLLKKMNKKEIEIISTGLRDRKTILRLFEYAAFFIFRICSSNGIGMSLDLWKHNIVFNKILKDQSINNKLLVKDEELFEKDKDFLIMAANTFEIIMKNEVFVNSFNISEKCVLYTLSIYGELGFFPKNKDKIWSKKFYSLLESLPFNILLSTLIRLNNPRCPGWMREVICKELSKVTRKPGGITAIVEFIKVTLYENEITINDLDKVVSLVTLIPKDIEKEEYIKSISPELLSMLDHPFEKSYLYQTSGRIISVLLLNYPELTQNYIISKIIELLHTPKQNQNDESIDNAIKRIERICLQSDSNIIVNVISPIFIVLWAASCFSHKTHKYMWRDRIISILLSYIFLSCQLTSIWRIIENFLSTGDTYFSFSNGEQGGISIEINNSNIILSIEDIDSRIENFSLLIDKFRNDQKLIEDIFLKLLNYWLNKNKNSEEDQDPLNELYYLKILMLIQNNYLTEITKNTEKIFQILMEIISNFNKNYKLSQSMRNSKDIDQPFLKNLHKIVKDDTDLRIIDEDISIVMISLNILNIILASNPKLSEKEVSLLDTIQHQLAYMSKNSVDSLRSCAQNLNILVKSYLIFPIISDQNKNSQIEDSKRKYNKAIQYTFDQLVPVRAQGISLLKEMIEAKDPIVDVSEVLNLLIGLIKDNDSFVYLNAINCLTSLSNNHSNYIIEYLLSEYANVLKYKLDERIRIGDAIFKIIQNIGKMIHGKISDSISRTMLDISTSSTNDIRIRSSALSILGIACKCSFYGMDKWCFIALKSVLDILNFEKTDEYIILRRAAIILIANILEGTDDLISIPSNLLRSTLKTVRYIQVADQDILMRRQALGLLDLMKQKLHEKIGLYSHDTILNIIQFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVS7</accession>
    <name>M7NVS7_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_00825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872732.1">
        <property type="nucleotide sequence ID" value="XM_007874541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVS7"/>
    <dbReference type="STRING" id="1069680.M7NVS7"/>
    <dbReference type="GeneID" id="19894523"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00825"/>
    <dbReference type="eggNOG" id="ENOG502RX84">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_802061_0_0_1"/>
    <dbReference type="OMA" id="MLVEEYP"/>
    <dbReference type="OrthoDB" id="10264870at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22933">
        <property type="entry name" value="HFD_HFI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024738">
        <property type="entry name" value="Hfi1/Tada1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12767">
        <property type="entry name" value="SAGA-Tad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR11236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="337" mass="39031" checksum="F89548E01236657A" modified="2013-05-29" version="1">MSRVDIDPLLKKLQIALKTKWTQYQIIVTDFISGKMNREEFDQQINLILEKKYFRLHNEILLTIYTNAMCDPPEKSCIFGWTKKSKEYQRIRVNDQRKELKSEIMSLHYRDRLRIKSIKKAKMDSLGRSLISSNTLFESRIAKLPKMPLCKDKIFTDYASDIQRGYHVPLSCDSMEIPDIDSLRERSLAIALESGLIGGLKEGVPEIILAGLEYHLKNVLAIVIAKVRFQNFRRSTHTENLNNFILFNPNKPKRKQEIKKYSSLTIQELGLAFQLAPFSLVETPPPITRIWATTLTNNATYQDNKVEETILNVIKENPRCKKRFELALVLDELLAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVU5</accession>
    <name>M7NVU5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00282</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872153.1">
        <property type="nucleotide sequence ID" value="XM_007873962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVU5"/>
    <dbReference type="STRING" id="1069680.M7NVU5"/>
    <dbReference type="GeneID" id="19893980"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00282"/>
    <dbReference type="eggNOG" id="KOG3609">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_321857_0_0_1"/>
    <dbReference type="OMA" id="DFWPLQG"/>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF4">
        <property type="entry name" value="MEMBRANE CHANNEL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="3">
        <location>
            <begin position="228"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR11251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="900" mass="104599" checksum="4A041E53D159D4DC" modified="2013-05-29" version="1">MEGSQIHDHLWSTLDLDQIPVYNLVHSVREDVFTSVDSKTDHFQLRGPQINSLLVRPILEKCKKKKSHAIVYALLVNQVQFIKEASENALMTSINTTCAVVCELVAIKILKYFKSEELIDVLTYDFWPLQGASLDYTDMAFIGANKISAIEVAIRAEAKRFLSVPVVVQILENIWKGNIVFYSSSDKNDFIPESYRRVSTIYDSRECSILKLSRLRVPKYRHYMATVSFAIMLALVTATLIQNIPQITTLELVMDFWAIGFILDEIMGIANSGTRLYLLNLWNIFDVILFCIFIGFLALRLYGLFIDDPEHKISRIAYDILATNAIFLFPRLFSTMDYYRYFSQMLIGFRKMAIDFFTTLILIIIIFSGFWVALSLAFARDSYSPKSLAFRLMQLFFGFSPAAWDMMDNLNILGQTLLILFMANSNYFVVTALVSVLSNSFASVRANAHEEHQFLFAVNTISSVKSDAYFFYQTPFNILQWIIYPLVYILSKQSYMKLNWYVIKITHFPILFTIFLYERFCLRQKTFSTTELGLSRAKSIDTIDNDYFGTFVKENRAASAVLKRKSRCDSLAVQMRDQLLDHVFKIPYNTFKNNGKNYSKNSIGDYTIDKWLISPSRTFFTMDKLDENDSFNQNENIKQIPSELKKKKSINSHEYEKKYSSDFSQIGTNFNFDEFEKNSIQTKINLLNSYSLQKEKRPGILKEHCNNINDNDYGEATIFMDNECYDEFEQCSTNINKNIGKYSLFDDNLRQMHYFQKNSENILPKFKTLESIKTSNLSKQNPTLTMSQNIQNHSYKEQFMPTYSPFKFENEPYSINETDKLMNMSKLFSRLYQNKPFDNEAIKESNNIESKTKVQIYNNGVLESMLLEKLDAIENFVKIRVDHLEAICIEIIAEIKKLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>M7NW01</accession>
    <name>M7NW01_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM7</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MCM7</name>
        <name evidence="14" type="ORF">PNEG_00501</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872388.1">
        <property type="nucleotide sequence ID" value="XM_007874197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NW01"/>
    <dbReference type="STRING" id="1069680.M7NW01"/>
    <dbReference type="GeneID" id="19894199"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00501"/>
    <dbReference type="eggNOG" id="KOG0482">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000995_7_2_1"/>
    <dbReference type="OMA" id="AQHVTYV"/>
    <dbReference type="OrthoDB" id="3207464at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033679">
        <property type="term" value="F:3'-5' DNA/RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904931">
        <property type="term" value="F:MCM complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006267">
        <property type="term" value="P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17758">
        <property type="entry name" value="MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000004">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000288">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24901">
        <property type="entry name" value="WHD_MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="363"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR11487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="759" mass="86285" checksum="482B30BA8D7E83DE" modified="2013-05-29" version="1">MSFRNALPTVNINVDYLKIQERIQDFLLNFIESSKIVNDIDDDSSVNRDTLHCEDFGSKYMKELQAIANRTKDSITIDLKDLEAYDTNNKDLVNNIMNNTKRYNDIFYRAIDNVMPVPTVDISYSDDVMDIIMQQRLQRNEVNQNNGSDNLFPPQLTRRFSLYFKPVDIYEKGNIKIYTVKELKSLHLGHLVTVRGIIIRVSDVKPSLQVNAYTCDHCGCEIFQEIKTKHFTPMIQCISEECRKNNSKGQLFMSSRASKFIPFQEARIQELTNQVSVGHIPRTLVIHLYGSITRSINPGDIMDVSGIFLPMPFLGFKAIRAGLLTDTYLECQYVVKLKKQYDIIENTPEMVRQIEKLSTSGNVYEQLSKSIAPEIYGHDDVKKALLLMLVGGVTKEMYDGMKIRGDINICLMGDPGVAKSQLLKYMSKVAPRGIYTTGRGSSGVGLTATVMRDPVTDEMVLEGGALVLADNGICCIDEFDKMDETDRTAIHEVMEQQTISISKAGIVTTLNARTSILAAANPLYGRYNPRISPADNINLPAALLSRFDILFLILDTPAKDEDERLARHVSFVHMNNRHPDITFQPLDPVTIRSYISQSRLKRPVISKSVSDYIVGSYVQMRQKQKNDNAMKRQFTHTSPRTLLGILRMSQALARIRFSDIVEIGDVDEALRLIEVSKLTLYEKHDYDSDITSKIYKIIRDLANGDGYEFVDEWNMKIIRERVLAKGFTENQLVDCIKEYQDLGVWQLRLDGSKLIFITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NW33</accession>
    <name>M7NW33_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872419.1">
        <property type="nucleotide sequence ID" value="XM_007874228.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NW33"/>
    <dbReference type="GeneID" id="19894228"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00530"/>
    <dbReference type="eggNOG" id="ENOG502QT5T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004060_0_0_1"/>
    <dbReference type="OMA" id="IHGCLLW"/>
    <dbReference type="OrthoDB" id="46159at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060172">
        <property type="term" value="P:astral microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF9">
        <property type="entry name" value="CLIP-ASSOCIATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="7">
        <location>
            <begin position="2"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="7">
        <location>
            <begin position="286"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="600"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="600"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR11517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1364" mass="153680" checksum="B5E757D23BA05524" modified="2013-05-29" version="1">MSIQDAEDLQDALRGTDNDRKLEMIMGIKRFIKRNDVNLEAVPLLFDGLRIGLISTNPYVVMNCLTCTNHLIKRVSLQEISRLKGPGVMVLPLLIERLGDIKEKVKDVAQNALIELWKGIPSEVERSIKDLGFSSKNWRTREQSLYWLAKIYGSQSSFSFRTFTPFMIKMLEDANDSVRDAAKIVIIELFKNSPNYAKADLKRELNQQNIRKKLVIYILDNLQLQGDTDFVSSRGSECAYDNDGASISARKVKNESIASLSNLSSNYISNLSGAEMEQMEPSWVYSAKELESEIQEMLPSFEGKETDYNWVAREKHIMRLRSLLRGNVYKEYSPIFLNGFKTLLDGIIKAISSLRTTLSLAGLQFIKDVAIVVGPAIDQFVEILLIHLIRISGLTKKIISQAAQITVSILIANVSYHPKIVQQLLTASQDKNPSTRQYATGWLRTLLEAHIDSRAYLENSGGLDIMEKVIRNGISDANAVVRTGMRDVLRCFSEIWPERTQSLVSSLDPVVRRQFEKVFQNSSVFSKSIDSVNKCHNLSQNYSLNKGKSFNKEPLVKSGNIVNRKSDDTFGVSHGLSGLSSGPIRHGLGLPQRYGYSSKSNVKISESPSQDQLTGNTSNQTHTSPSQLRNEMSPPRPTLVANSLFGKPLMTSSRISPRKLTIIEQLVHSDWHIRVDGIITVACLLAKKTPPNYDNQKLPILPPNDILASTFQKLLNDSQPEVVNHLMAPEVIVEIAKIIPFENIVPRILLLSEMEDTERGHDIARTCLPAVKRMISDVDAAELLSKVLTSMGVSGVVPRKLSAGIFTTSQKRKIIHGVLLWMNELVERHNESIKNKEDGNSYFNDVSNFKFYVNRLVPMINNTKPTSINYGPLATLLKSLQTTNEEVFNKVLQTFEKVTVNALKNAWGIAVEEEPFVPEEKVAHIEDVLGGIPIVGDSKLDGNDMEHSSSSMESHSIKYSDNYIDSFEENIGVHNNFEDMTMIQIPKLQVNISNNGVNKEVRSVSSDPFVSVGVKPALIIDDAIKTYDSKTSGDKVAQEQQASEVGQELFPQSSELEPTLDFENQEDQDIPIEDDSFSGNSNLWFRKYMKKQLPITPLPNTVEDNIKLLKNLIERLENHDMDSYAFRKLICISKEYSLETNLENSDNISDNSKKDDVWMAGSLFDSLIKALLGFMREDVVSELKVQALFLLKYLFDHQSVYFYNHISIVFDVLLKFRSYDSNNNRVTCVIEEMTFDIVSHFDPKIGIELFLSYLEPYLYNLTDGSKKHLLKQSIIVICLSSLAIFIKKLEKTYLDKYLEKIPSLVIKSLNDGDPEIRKESITICVSLNSIIKDSSEIFNLLQGLTPGQQNLLAYYFAKSCGKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWA3</accession>
    <name>M7NWA3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">F-actin-capping protein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00439</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
            <location evidence="1 8">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the F-actin-capping protein beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872317.1">
        <property type="nucleotide sequence ID" value="XM_007874126.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWA3"/>
    <dbReference type="STRING" id="1069680.M7NWA3"/>
    <dbReference type="GeneID" id="19894137"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00439"/>
    <dbReference type="eggNOG" id="KOG3174">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045864_1_1_1"/>
    <dbReference type="OMA" id="WSNKYYP"/>
    <dbReference type="OrthoDB" id="9979678at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099079">
        <property type="term" value="C:actin body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000142">
        <property type="term" value="C:cellular bud neck contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904600">
        <property type="term" value="P:mating projection actin fusion focus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902404">
        <property type="term" value="P:mitotic actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.570:FF:000001">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001698">
        <property type="entry name" value="CAPZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043175">
        <property type="entry name" value="CAPZB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019771">
        <property type="entry name" value="F-actin_capping_bsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA ISOFORMS 1 AND 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01115">
        <property type="entry name" value="F_actin_cap_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00192">
        <property type="entry name" value="FACTINCAPB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00231">
        <property type="entry name" value="F_ACTIN_CAPPING_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0117">Actin capping</keyword>
    <keyword evidence="6 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="263" mass="30408" checksum="06A2777D9C8FC7FF" modified="2013-05-29" version="1">MTEQLDAALDLFRRLPSQDIARNIVAVLEKVPYLTEDLLSSIDQPLQIKKCPKTSKFYLSCDYNRDGDSYRSPWSNEYTPVLPDGIVPSERTRKLEIAFNEAFDIYRTLYYEGGTSSVYLWDLDNGFAGVVLIKKESSKKGYWDSIHVFEVPYGSRTVRYRLTSTIILHMVTQSELLGQMNLSGNITRQVEQELLVNDLNSHIVHVGRLVEDMEIKMRNILQEVYFGKTRDICNDLRSISKLSRQKEGVQLQREVVEKLSNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWR2</accession>
    <name>M7NWR2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00156</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872017.1">
        <property type="nucleotide sequence ID" value="XM_007873826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWR2"/>
    <dbReference type="STRING" id="1069680.M7NWR2"/>
    <dbReference type="GeneID" id="19893854"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00156"/>
    <dbReference type="eggNOG" id="ENOG502QUUG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_4_0_1"/>
    <dbReference type="OMA" id="DTWIMRR"/>
    <dbReference type="OrthoDB" id="2534523at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001238">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF34">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="7">
        <location>
            <begin position="816"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR11722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="928" mass="106689" checksum="5385354B312BC664" modified="2013-05-29" version="1">MQRILQINWIQVLKRYKHSISLSRYEIRPLLVDQNSLNKNIRIKDNLKASIEEKPSLEPLMNASGPVYTQLLDQVLYNQKKYANCVLLTRVGGFYELYFSQAEKYAPILNLKLARKDTKAGPVPMAGFPFYQLDRYLKCLVEEIGEYVAISEEYRRLDRCSTYKNIYERRVSRIVTPGTLIDEKFMNLYINNFLLAIHMNENIMKEKGLVQSLEIGLAWLDLSTGDFFTQTSKFEYILDELERINPKEIIIDKEFQEIFMEYISPYVKERECFVTYETFEIPDRMIQKWENIKNNNETSIFSVLEEHASLKILSYVNDKLQGEEFNLQAPVRRNSEENIFMDIHSIRALELKQSLREGGKTGTLLSAIKRTVTSSGSRLLTEWICSPITSISLINKRLNLVEIFYNDSHLRAEIVQLLKKIYDTQRVIQKISLGRKNADDLLALSKTIEITNRIYNCLEKLSDKESVNSLLKRIIIPLDLFKKIQNTIDEDGLMQKQKENEEIIADAMEKAIEIERMSKSQDFSNNDLIESKLKTNQDFKNNDIWIIKKNASLPLKKLHEELNTLYDQKDKLQESLKLLLGTTNLTLKTTHSLNHIIHLRNKNTEKSISEINGAKVLSTNKSTKSIQIPEWTHLGNMIEQTKIKIRLEESNTIDNLRIETLKNLSILRKNAKVLDELDIASSFATLALEQKLVRPILKTGTYHKIISGRHPIVEAGLYNRGLVFVPNDCSLGEKKRIWFITGPNMGGKSTYLRQNAIISILAQIGSFVPAAYAEVGIVDRIFSRIGSNDNLYKNESTFMIEMLETARILKRATPKSLVIMDEIGRGTTYKDGLAIAYACLYHLHYINKSRVLFASHFHELVNMISLFDSVSMYCTKVIEEGDGSFRFLHKIAEGVNDNSHGLKVAMMAGLPQKAIQVAKETLKKLNGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWR8</accession>
    <name>M7NWR8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-hydroxyanthranilate 3,4-dioxygenase</fullName>
            <ecNumber evidence="8">1.13.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">3-hydroxyanthranilate oxygenase</fullName>
            <shortName evidence="8">3-HAO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">3-hydroxyanthranilic acid dioxygenase</fullName>
            <shortName evidence="8">HAD</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Biosynthesis of nicotinic acid protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BNA1</name>
        <name evidence="9" type="ORF">PNEG_00161</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:17953"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:77612"/>
            <dbReference type="EC" id="1.13.11.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the 3-HAO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.6" evidence="8"/>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872022.1">
        <property type="nucleotide sequence ID" value="XM_007873831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWR8"/>
    <dbReference type="STRING" id="1069680.M7NWR8"/>
    <dbReference type="GeneID" id="19893859"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00161"/>
    <dbReference type="eggNOG" id="KOG3995">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095765_0_0_1"/>
    <dbReference type="OMA" id="KPPVGNQ"/>
    <dbReference type="OrthoDB" id="204928at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000334">
        <property type="term" value="F:3-hydroxyanthranilate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06123">
        <property type="entry name" value="cupin_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00825">
        <property type="entry name" value="3_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010329">
        <property type="entry name" value="3hydroanth_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03037">
        <property type="entry name" value="anthran_nbaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497:SF1">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06052">
        <property type="entry name" value="3-HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="169" mass="19655" checksum="9FEC3223BA56BF8E" modified="2013-05-29" version="1">MLSAPINIQTWLDAHADKLKPPISNFCLWNEGFTVMVVGGPNSRADYHVNETPEYFYQYKGPMTLKIIDEEGEFKSIFIKENEMFLLPENIPHCPIRYENTVGIVIEQKRPKDSMDRLRWYCTDCKSIVYEEIFRCTDLGTQIKAVVEKYSNNIELRRCKSCGKTNDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NX34</accession>
    <name>M7NX34_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_00269</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872142.1">
        <property type="nucleotide sequence ID" value="XM_007873951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NX34"/>
    <dbReference type="STRING" id="1069680.M7NX34"/>
    <dbReference type="GeneID" id="19893967"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00269"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046889_0_1_1"/>
    <dbReference type="OMA" id="KAHPMHP"/>
    <dbReference type="OrthoDB" id="3214149at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR11847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="278" mass="32355" checksum="840A5B1E8073A7D0" modified="2013-05-29" version="1">MTQLTINCPSSKNGLSLFDSQSSIQNSSVSKTYQDNCSSISSDTSGSLPDVPREKSSIAAVCKWNRCFKDQGSLENLVNHLYYVHIGNTRTTYICEWDHCSRKKIVPMSRFALFVHLRSHIGEKLFFCRVPECQKLFARFDNLENHMKIVHYLDFISSSTLSSHIQNPYSETHFISNKDVQNFLLKNEAKYFCNKEFTENSQDESTDFLEEESVMSFYDLSKLLKQKLHWIKEKNQRLKSELHRAQKRCKRYYIQKEGAFEKLLIKSLGKNNAASIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NXC2</accession>
    <name>M7NXC2_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00237</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872106.1">
        <property type="nucleotide sequence ID" value="XM_007873915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NXC2"/>
    <dbReference type="STRING" id="1069680.M7NXC2"/>
    <dbReference type="GeneID" id="19893935"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00237"/>
    <dbReference type="eggNOG" id="KOG0832">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040318_4_0_1"/>
    <dbReference type="OMA" id="PYIFMEK"/>
    <dbReference type="OrthoDB" id="2320368at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_uS2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_uS2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S2 PROKARYOTIC AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR11811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="301" mass="34240" checksum="B1C006AC6A3FE6A2" modified="2013-05-29" version="1">MLTFSINFLINKIRNTKLFIDSYNPFFCLNSPFQLFRNKLIKKFTTQRRTLSKNEIQIIRTKLSKSNKNIGSILLDKYQPHENIHKPLSQKHLTLSLLLSSQVHIGHSTSLWNVATHPYIYGVRQGIHIINLDTTITHLRRACTVVSGIAAKKGIILFVGTQRNQKDCVIKAAKRANGFHVFDRWIPGTITNRYQVLKHGKIKKSSIIINGKKITQNDERMCHFSTLPDLVICLNPMQNKILLRECAKAHIPTIGIIDTDADPKYVTYPIPCNDDSLRSVEMVVGILSCAAENAKVKENQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7P2F0</accession>
    <name>M7P2F0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_03500</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875592.1">
        <property type="nucleotide sequence ID" value="XM_007877401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P2F0"/>
    <dbReference type="STRING" id="1069680.M7P2F0"/>
    <dbReference type="GeneID" id="19897187"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03500"/>
    <dbReference type="eggNOG" id="KOG2907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093932_1_1_1"/>
    <dbReference type="OMA" id="EMQYHTL"/>
    <dbReference type="OrthoDB" id="10056816at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10507">
        <property type="entry name" value="Zn-ribbon_RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034004">
        <property type="entry name" value="Zn_ribbon_RPA12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF14">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="12">
        <location>
            <begin position="76"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR08060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="119" mass="13312" checksum="F3A5C1FCD21FB201" modified="2013-05-29" version="1">MFSVGSAFFCTSCGSLLDLISDMYIVCTQCRASYPTSDIPDFNIVTTSRSKAFGSSLRQMDISLNSLETDTAASIINETCPKCEYKKMRFQTLQMRSADEGATVFYECLFCGYRFSTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7P2S3</accession>
    <name>M7P2S3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]</fullName>
            <ecNumber evidence="16">1.3.1.90</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">tRNA-dihydrouridine synthase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PNEG_03348</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(20a) in tRNA + NAD(+) = uridine(20a) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53348"/>
            <dbReference type="Rhea" id="RHEA-COMP:13535"/>
            <dbReference type="Rhea" id="RHEA-COMP:13536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.90"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53350"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>5,6-dihydrouridine(20a) in tRNA + NADP(+) = uridine(20a) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53344"/>
            <dbReference type="Rhea" id="RHEA-COMP:13535"/>
            <dbReference type="Rhea" id="RHEA-COMP:13536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.90"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:53346"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5,6-dihydrouridine(20b) in tRNA + NAD(+) = uridine(20b) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53352"/>
            <dbReference type="Rhea" id="RHEA-COMP:13537"/>
            <dbReference type="Rhea" id="RHEA-COMP:13538"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.90"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:53354"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5,6-dihydrouridine(20b) in tRNA + NADP(+) = uridine(20b) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53356"/>
            <dbReference type="Rhea" id="RHEA-COMP:13537"/>
            <dbReference type="Rhea" id="RHEA-COMP:13538"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.90"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:53358"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the Dus family. Dus4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.90" evidence="16"/>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875428.1">
        <property type="nucleotide sequence ID" value="XM_007877237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P2S3"/>
    <dbReference type="STRING" id="1069680.M7P2S3"/>
    <dbReference type="GeneID" id="19897035"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03348"/>
    <dbReference type="eggNOG" id="KOG2335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013299_4_0_1"/>
    <dbReference type="OMA" id="QRPHHDI"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106414">
        <property type="term" value="F:mRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102266">
        <property type="term" value="F:tRNA-dihydrouridine20a synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102267">
        <property type="term" value="F:tRNA-dihydrouridine20b synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000159">
        <property type="entry name" value="tRNA-dihydrouridine synthase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF31">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20A_20B) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="19">
        <location>
            <begin position="41"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00060741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00078338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMR08175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="345" mass="39308" checksum="2B3C8418B1F94F4C" modified="2013-05-29" version="1">MVMVSEIDVFEHLSLRNIEDHPLKLFSAAKCEKRPLYISGPMVRYSKLPFRSLVRIYGVDLAYTPMMVAKEFLFHSNARYCDFSTNLDDRPVVSQFASNDPIILGRAVEIISNYVDGISLNCGCPQSWVCQEGLGAHLMHDLQNVCEMVKAVKERCGRQMCVEVKIRIHGDLRKTVDWAQKVQAAGIDYIVVHGRRRNQRSSEPVNLNAIKLIKESLNIPVVANGDVFTFSDVNNIAKYTNADGIMSSRGILANPALFSGFDTCPWSAIERFIEYSLSYGLNFHLFKYHILKMMGKILNKKESCELSNQMSIAEILDWIDERFILRRPGDSEFGNIHTYQRKLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7P368</accession>
    <name>M7P368_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Man1/Src1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_03427</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875514.1">
        <property type="nucleotide sequence ID" value="XM_007877323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P368"/>
    <dbReference type="STRING" id="1069680.M7P368"/>
    <dbReference type="GeneID" id="19897114"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03427"/>
    <dbReference type="eggNOG" id="ENOG502QVG5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YILSEPW"/>
    <dbReference type="OrthoDB" id="2503928at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12935">
        <property type="entry name" value="LEM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025856">
        <property type="entry name" value="HeH/LEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044780">
        <property type="entry name" value="Heh2/Src1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018996">
        <property type="entry name" value="Man1/Src1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN HEH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808:SF2">
        <property type="entry name" value="LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12949">
        <property type="entry name" value="HeH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09402">
        <property type="entry name" value="MSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="HeH/LEM" evidence="9">
        <location>
            <begin position="12"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Man1/Src1-like C-terminal" evidence="8">
        <location>
            <begin position="302"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="61033" checksum="F551A82DBF80B9EE" modified="2013-05-29" version="1">MLQDYLDENFDAKSLRIADLRRILFENNVNYPSSAKKQVLLDLFYEHIVLGKKGYLKEKKHENKDEYDILSDNISKIKQVKQKSSKKKGKKQLNDSKETLSANRYSHMSLRRSISDQPSNIEDKEKLEEKSLSLDEGFSNENFFQQTSPLCETYKFRSSLQPLMPEAHQKEVVDILEVPEKSSIMRVKPELRSKSLVQPLMNTTLPRSKPKKFMTNIENLKTSQQFYHMTMYSKPDNELTTQTSENNEFTHNDLPLNNNETESKDKLDLNKEVLNVFYGKSKVKPKRKKFSFIRFFVVFIFSTSIATLGSIWREETIRVGYCGVEIKEIPNTYSLIRGKLPRILLNNLFVYCKPCPDHAICYPNFKLVCQKDYILTPNILSFNGLIPIVPSCIPDTEKLRRVHIIINEIIQMLRDKNAKLECGSSKLLKGEKEGIYEKDLEKYLWEMKSPDIDDQQFQELLSDAFEDIVTYDEIHIEKDGYIDLIDQKDILNQHLFQTFHLDAHLKNISDEDWYAIESSLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M7P5C3</accession>
    <name>M7P5C3_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_02426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874432.1">
        <property type="nucleotide sequence ID" value="XM_007876241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P5C3"/>
    <dbReference type="GeneID" id="19896119"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02426"/>
    <dbReference type="HOGENOM" id="CLU_2513598_0_0_1"/>
    <dbReference type="OrthoDB" id="15433at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR09080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="85" mass="10235" checksum="C3DCB895E786EED0" modified="2013-05-29" version="1">MIHGIGIDIVHISRMIKILDRRTRFMEKICQRILRFDEQDIIPNLKNKNQFALWICTKFIRKVLAFLKRNNCIIDGQQKKLLLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7P7G5</accession>
    <name>M7P7G5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01968</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873946.1">
        <property type="nucleotide sequence ID" value="XM_007875755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P7G5"/>
    <dbReference type="STRING" id="1069680.M7P7G5"/>
    <dbReference type="GeneID" id="19895662"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01968"/>
    <dbReference type="eggNOG" id="KOG1412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032440_1_2_1"/>
    <dbReference type="OMA" id="MGFEMFC"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000066">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF20">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="31"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="405" mass="46246" checksum="256BE335F5E37FBA" modified="2013-05-29" version="1">MENSLFEDVPYIEKDVIFELMRLYKDDKFEKKVDLGIGVYRDNYGKPCLLSSVRKAESIIITDPNYNHEYLPIDGLPSFIEASKKLVFGENSPLINSGCVSSVQTISGTGANHLGSLFISLFNKGAVCYFSRPTWSNHDPIWKHAGLTIREYPYFDESTCGFDFEGMITTLQEAPENSIILLHVCGHNPTGVDPTREQWIKICDVMKEKKLFPFFDFAYQGFVSGDIDEDAWPIRHFSERGFELCVCHSFSKSFGLYGERCGCFHLVVKSPDIAKNVHSQLVRIQRNEISSPPSYGAKIVSLILNNEQLTQEWKKNILEISNRIKEIRKLFYQELIRLGTPGSWEHIINQVGMFSYLSLSEKDICRLVNEFHIYIPSNGRISISGLRTGNLEYVARAFDTVVRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7P9C0</accession>
    <name>M7P9C0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01169</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873084.1">
        <property type="nucleotide sequence ID" value="XM_007874893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P9C0"/>
    <dbReference type="STRING" id="1069680.M7P9C0"/>
    <dbReference type="GeneID" id="19894866"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01169"/>
    <dbReference type="eggNOG" id="KOG4756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131055_3_0_1"/>
    <dbReference type="OMA" id="WENLNPR"/>
    <dbReference type="OrthoDB" id="408933at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019189">
        <property type="entry name" value="Ribosomal_mL41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09809">
        <property type="entry name" value="MRP-L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="12368" checksum="280436D87D630F66" modified="2013-05-29" version="1">MLKPSQILEGAKRLPMTSKQGRQFYKGSRTGSMGRHTKRGGYIIDWAKVRTFIVPNGLDTTPLKPFVTLKVRPIRSSFGPGQKHGFDGNIYYKQWKEENPEEKKENIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7P9F5</accession>
    <name>M7P9F5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MED10</name>
        <name evidence="7" type="ORF">PNEG_01211</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873129.1">
        <property type="nucleotide sequence ID" value="XM_007874938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P9F5"/>
    <dbReference type="STRING" id="1069680.M7P9F5"/>
    <dbReference type="GeneID" id="19894908"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01211"/>
    <dbReference type="eggNOG" id="KOG3046">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096169_1_1_1"/>
    <dbReference type="OMA" id="QYQRAKM"/>
    <dbReference type="OrthoDB" id="337270at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019145">
        <property type="entry name" value="Mediator_Med10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09748">
        <property type="entry name" value="Med10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="144" mass="16874" checksum="75CF6F24E38E6330" modified="2013-05-29" version="1">MDKSTSSTQTTIHNLHNLETHLESLIHNLHDLGKIIHDFENSKTNEIIFNRIKNIINNYKSLYTNKDFITEIVPRDVIDYIEEGRNPDVYTRQFCELVQKDNQYVNGKSIAITDFRNILAQDIKNNFPNIANEVEKILRNTNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7P9W6</accession>
    <name>M7P9W6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDB1- and CUL4-associated factor 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">WD repeat and SOF domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_01365</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat DCAF13/WDSOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873294.1">
        <property type="nucleotide sequence ID" value="XM_007875103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P9W6"/>
    <dbReference type="STRING" id="1069680.M7P9W6"/>
    <dbReference type="GeneID" id="19895062"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01365"/>
    <dbReference type="eggNOG" id="KOG0268">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033999_0_0_1"/>
    <dbReference type="OMA" id="EDHNAYI"/>
    <dbReference type="OrthoDB" id="10249065at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001074">
        <property type="entry name" value="Probable SOF1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001105">
        <property type="entry name" value="WD40-repeat-containing domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039462">
        <property type="entry name" value="Nup159/Nup146_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007287">
        <property type="entry name" value="Sof1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF0">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16755">
        <property type="entry name" value="Beta-prop_NUP159_NUP214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04158">
        <property type="entry name" value="Sof1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5 10" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="63"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="106"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup159/Nup146 N-terminal" evidence="13">
        <location>
            <begin position="190"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="272"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="315"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Sof1-like protein" evidence="12">
        <location>
            <begin position="348"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR10665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="439" mass="50069" checksum="5475FF4851C56309" modified="2013-05-29" version="1">MKIKVLSRQRSLVVASRLGDQNPMPRNLNFAIHPFERAREYVRALNSVKLDRLFAKPFIGQLGNGHIDGVYCMAKDSRKIDTIATGSGDGVVKIWNLIERNEVLSIDAHDGTVNGLTYTTEGHLLSCSADKIVKLWSLNSIDPINIYMGTDAFSSVDHHYSKPIFATSSTKIDIWDENRDKPIFSMEWGADTIQTVKFNHSETNIVASAGADRSLILYDIRTSKPLSKLITQLRTNSICFNPMEAFSFAAASDDHNCYIYDIRNLTFAKNVLKDHVSAVMDVDFSPTGQELVTGGYDKTIRIFNIKEGHSRDIYHTKRMQRVFSVKFTSDSNYILSGSDDGNVRLWRANASSRMHILSTRERTKMEYANVLKQRYKNMPEIKKISNSRNVPKVIIKMQKTKKEELTALKRKEENRRRHSKPSSISYIQERKKHIVALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7PA23</accession>
    <name>M7PA23_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">COQ4</name>
        <name evidence="9" type="ORF">PNEG_00860</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid into 2-methoxy-6-(all-trans-polyprenyl)phenol during ubiquinone biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + H(+) = a 2-methoxy-6-(all-trans-polyprenyl)phenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:81179"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="4.1.1.130"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion inner membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the COQ4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872770.1">
        <property type="nucleotide sequence ID" value="XM_007874579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PA23"/>
    <dbReference type="STRING" id="1069680.M7PA23"/>
    <dbReference type="GeneID" id="19894558"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00860"/>
    <dbReference type="eggNOG" id="KOG3244">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061241_2_1_1"/>
    <dbReference type="OMA" id="WFEMINT"/>
    <dbReference type="OrthoDB" id="4249at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120539">
        <property type="term" value="F:4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03111">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007715">
        <property type="entry name" value="Coq4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027540">
        <property type="entry name" value="Coq4_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05019">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00081568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="177" mass="21054" checksum="3604C87EA17CC231" modified="2013-05-29" version="1">MLINSTGRRILFERPRMTLVTLNPKFLHTLPDYTLGNIYIKWMDTYGFVPGLRSCVRYINHEEWAYVMQRYRESHDFYHILMGLPATIEGEILLKWFEWINMGLPIAILSAIFGSFSLFLKKKCKNISYPLIKWAIQNGQQARESMINIYWEEELKTDINILRKRIGIIPYDLKESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7PA79</accession>
    <name>M7PA79_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acetyl-coenzyme A transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00899</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872810.1">
        <property type="nucleotide sequence ID" value="XM_007874619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PA79"/>
    <dbReference type="STRING" id="1069680.M7PA79"/>
    <dbReference type="GeneID" id="19894597"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00899"/>
    <dbReference type="eggNOG" id="KOG3574">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020502_2_0_1"/>
    <dbReference type="OMA" id="RRKSWIM"/>
    <dbReference type="OrthoDB" id="6415790at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008521">
        <property type="term" value="F:acetyl-CoA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035348">
        <property type="term" value="P:acetyl-CoA transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000289">
        <property type="entry name" value="Acetyl-coenzyme A transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024371">
        <property type="entry name" value="AcetylCoA_trans_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778:SF9">
        <property type="entry name" value="ACETYL-COENZYME A TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13000">
        <property type="entry name" value="Acatn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="547" mass="63725" checksum="D51EA7A8721AF9E6" modified="2013-05-29" version="1">MNQQKSLFERAQLWMYGRKQNVLSICRKIGYLDNKQNKKRMQQKKFNEDVNSRKRSMNFFKIHNIQEKEQTNCMSSIILLIFLYLLQGVPLGLVMGSLPYLLQPYLSFTSLGFFSLASYPYSLKLFWSPIVDTVYNEKWGRRKSWVIPVQGSIGLCLLWISYNIQQWIEEATKSLKQITAVFFVLVFLCATQDIAVDGWALTLLSEENLIYASTAQSIGLNTGYFFSFTVFLAFNSSEFSNKYFRSVKKDFGLISLTGYMRFWGWVFLISTMFISFFQDEPRKKYSSVSIKNAYLIIFNIIKLRNVRLFVFVHLIAKIGSSATEATLNLKLLEKGLKKEDLSIAILINFPFELIFGYYAAKWSSMSRRLLPWTYAYIGRLIAAFIGILIVYKFPYDGKINTEYFYIIILQNMISSFMNTIQFISINAFHTRIADPIIGGTYMTLLNTVSNLGGTWPRYFVFESIDFFTKSYCSKNITNKCMTHEQITFCKELNGHCIKKVDGYYIINFLSIFTGFLLFFIFIKPSVEKLQKLPLKAWKINIIDRMSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAQ0</accession>
    <name>M7PAQ0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872997.1">
        <property type="nucleotide sequence ID" value="XM_007874806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PAQ0"/>
    <dbReference type="GeneID" id="19894782"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01085"/>
    <dbReference type="HOGENOM" id="CLU_2498796_0_0_1"/>
    <dbReference type="OrthoDB" id="2120024at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="86" mass="10419" checksum="D3775E76F3740677" modified="2013-05-29" version="1">MYSQETGIMSAKEHNYEGKTSHKLFWRIYARPFGKVFLLASITYLSLHFFWWHLYSEEKKREKKEYLFQLEKTLHELASNSKSKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7PB99</accession>
    <name>M7PB99_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GTP-binding protein rho4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00760</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872662.1">
        <property type="nucleotide sequence ID" value="XM_007874471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PB99"/>
    <dbReference type="STRING" id="1069680.M7PB99"/>
    <dbReference type="GeneID" id="19894458"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00760"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_21_2_1"/>
    <dbReference type="OMA" id="VHISLWD"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000983">
        <property type="entry name" value="Rho family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="168" mass="19314" checksum="9AE52D06A771016D" modified="2013-05-29" version="1">MYRFQEKLHPRPDFVKKLVVVGDGGCGKTCLLIVYSQGSFPEKYVPTVFENYVTNVYYGSNNKIVELALWDTAGQEEYDRLRPLSYPESDVILICFAIDYPSSLENVTDKWYPEVTHFCPNIPIVLVGLKSDLRKNRNAIGLLRSKGLNPVTYQQVFSIFLSVMFNHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7PBF4</accession>
    <name>M7PBF4_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00804</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872711.1">
        <property type="nucleotide sequence ID" value="XM_007874520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PBF4"/>
    <dbReference type="STRING" id="1069680.M7PBF4"/>
    <dbReference type="GeneID" id="19894502"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00804"/>
    <dbReference type="eggNOG" id="KOG1293">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002741_1_0_1"/>
    <dbReference type="OMA" id="KGTDQHV"/>
    <dbReference type="OrthoDB" id="5559898at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038739">
        <property type="entry name" value="ARMC8/Vid28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651:SF7">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR11215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="576" mass="63421" checksum="E5385155FBEF5EBE" modified="2013-05-29" version="1">MERLLEDILTSKEEQQVIALRTLKNQIIGYSERKKYFIEHQILSILIHILSSPETLEESQIQAIFILTSLAQVGYSFTSRICQAGTLHHLFMIFITKTSSPILITASLKALATILASASIAVTIPEPAIHHFVKILAKCCNQSSTPSEYFQASLVASIISACGKVPSQQNQLAQSGILDILIEIVSLFQDRSNQKPQQHFYRTKLLDAVLHALSSLTHNHDAHASQVAASYRSSTSNNPNDVYPMITNLLKLAKDPCISIQLGASGCLANMYRSGAIPKKYSTDLELIVIPILIRLLDESYKVKEHSLLILAYLVTDSDEMQGAACDADVIRKLANILHHVNNNPSPEMDNTNDKIIEAVLLAIAALTLFKDDYRKQVINAKIVPHIVSALSHQSAEVRVAACQCTRSLSRSVCILRSNLVDAGITDPLFVLLTDENLKVKTAACAAVCNLVLDFSPMRSAILEKGALKIMCEHAKNENSALRLNAVWALKHIVYAAETSVKKNVLEELGYNVLTELCNDPEVSVQEQALDVIRNVICGQQENIDILLNNIGVSKILSIIKKKLSSDFTEIITAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7PBT1</accession>
    <name>M7PBT1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872227.1">
        <property type="nucleotide sequence ID" value="XM_007874036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PBT1"/>
    <dbReference type="GeneID" id="19894052"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00354"/>
    <dbReference type="HOGENOM" id="CLU_1171044_0_0_1"/>
    <dbReference type="OrthoDB" id="5317157at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="237" mass="27521" checksum="E89F22F993062C0B" modified="2013-05-29" version="1">MQAEEFLKISEEKTLPPLEQETKKQTKKIRRCGICKKVGHSRNVCPNNKDLNIPFEWNRSTETFCGMITPTHGKASNIPLTKNNKKRKSESNPSNGAKTPTNCELGYTNITQKTPCSMGKNRLFINSYYQDNKENGLFSHVHPFKVYNNLEEIIPSMDFLFPYENMKWYESMEYSVDFENIQPGSRKDMLAFCKFNSYKKINYEDILDDSPLFKPLSNSIFDFIEDEMGSKSPILNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCF0</accession>
    <name>M7PCF0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_03586</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 16">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the RPAP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875680.1">
        <property type="nucleotide sequence ID" value="XM_007877489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCF0"/>
    <dbReference type="STRING" id="1069680.M7PCF0"/>
    <dbReference type="GeneID" id="19897273"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03586"/>
    <dbReference type="eggNOG" id="KOG4780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1305315_0_0_1"/>
    <dbReference type="OMA" id="HRENCTG"/>
    <dbReference type="OrthoDB" id="2590500at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043175">
        <property type="term" value="F:RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039693">
        <property type="entry name" value="Rtr1/RPAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007308">
        <property type="entry name" value="Rtr1/RPAP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038534">
        <property type="entry name" value="Rtr1/RPAP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732:SF0">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04181">
        <property type="entry name" value="RPAP2_Rtr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51479">
        <property type="entry name" value="ZF_RTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RTR1-type" evidence="13">
        <location>
            <begin position="21"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR08149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="211" mass="23987" checksum="76319351460A6A98" modified="2013-05-29" version="1">MIELQIMSLLLRPVDPQTLCSLGSKLRPQDYENVLLERNLEKFCGYPLCHNPPRDNKAPYKIMYSKRKIYDQRSLLRFCSTSCFKRSAFFAAQLSSEPLWLRNSDDMNICLLEESSEPLESSVDTNGVNVSVNTVDSNLNQDNLSSIKTSVHSHVLEKTHSSIFDIGISNMSFPIVERSLTMKSNVVEKFPDSKHYESIEGFVAPTGKWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCI6</accession>
    <name>M7PCI6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="13">FBP aldolase</shortName>
            <ecNumber evidence="5 13">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_03351</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="5 13"/>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875432.1">
        <property type="nucleotide sequence ID" value="XM_007877241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCI6"/>
    <dbReference type="STRING" id="1069680.M7PCI6"/>
    <dbReference type="GeneID" id="19897038"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03351"/>
    <dbReference type="eggNOG" id="KOG4153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036923_1_0_1"/>
    <dbReference type="OMA" id="PRTWGKL"/>
    <dbReference type="OrthoDB" id="35652at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00946">
        <property type="entry name" value="FBP_aldolase_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000013">
        <property type="entry name" value="Class II fructose-bisphosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006411">
        <property type="entry name" value="Fruct_bisP_bact"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01520">
        <property type="entry name" value="FruBisAldo_II_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006628">
        <property type="entry name" value="PRK09197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559:SF0">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE CLASS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00602">
        <property type="entry name" value="ALDOLASE_CLASS_II_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="264"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="285"/>
            <end position="288"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR08179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="357" mass="39750" checksum="9AB7E3E16C82771C" modified="2013-05-29" version="1">MGISSIVPNGVITGDNVLKLFKYAKDNEFAIPAVNCTSSSTIIAVLEAAKSTNSPIIIQISQGGAAYFAGKSLNNDKQQASIAGAISAAYFVRSIAPFYDIPVILHTDHCSKKLLPWLDGMLDADEKYFKIYKEPLFSSHMIDLSEESKESNIELTKRYLQRIAPMKQWLEMEIGITGGEEDGINNEEVSNNKLYTRPEDVFDVYSALSAISPYFSIAAAFGNVHGVYAPGGVFLRPELLKAHQDYAKQKLRCNEKPLFFVFHGGSGSSLEEYHAAIKNGVVKINIDTDTQFGYLEGVRDYILSKKEYLMSQVGNPEGLNKPNKKFFDPRIWLREGEKSMCNKVRALLNDFKTINTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCL9</accession>
    <name>M7PCL9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase F(0) complex subunit e, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_00093</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Subunit e, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase e subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871950.1">
        <property type="nucleotide sequence ID" value="XM_007873759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCL9"/>
    <dbReference type="STRING" id="1069680.M7PCL9"/>
    <dbReference type="GeneID" id="19893791"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00093"/>
    <dbReference type="eggNOG" id="ENOG502SDS3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159435_2_0_1"/>
    <dbReference type="OMA" id="AQREYKH"/>
    <dbReference type="OrthoDB" id="2125027at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008386">
        <property type="entry name" value="ATP_synth_F0_esu_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05680">
        <property type="entry name" value="ATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 11" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR11655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="91" mass="10683" checksum="E2466962AE4710B7" modified="2013-05-29" version="1">MEPVIQNVFRWSALVAGIGYGYTHRNTLAVKKKKKEQEELYKRKEDVIHKARIEYAKLHTLSLLKANSLDLNDPNFDLEAYLNRLEEESLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCP3</accession>
    <name>M7PCP3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2C-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871975.1">
        <property type="nucleotide sequence ID" value="XM_007873784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCP3"/>
    <dbReference type="STRING" id="1069680.M7PCP3"/>
    <dbReference type="GeneID" id="19893815"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00117"/>
    <dbReference type="eggNOG" id="KOG4784">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029122_1_1_1"/>
    <dbReference type="OMA" id="QAMKVFY"/>
    <dbReference type="OrthoDB" id="386949at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019193">
        <property type="entry name" value="UBQ-conj_enz_E2-bd_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09814">
        <property type="entry name" value="HECT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="41938" checksum="9FCA45B3E943F835" modified="2013-05-29" version="1">MNIEKPKKDLFFIAEALSHIRVINLVLEFSENIYQPSSLKLFNTHSIYIKSNEISEIIFLPDETEKDVSIQVNQQLNTLSIRLPLSNFSIKSLKEISPWSAVYIDPNSDFCCGFCLCFLLNKDQIKHWRNLPSDNWVDMMDYWVCCKEKYNAFGNYGMLQKIKSLSDSGIIFVGLSYFLISEKNLQNIKVEKNKALCNFCHMNIGILIEDGIKLYKWKLAEKNMEKIISFDIDIFISAELLALIEIYPDHKFDICNEESGKCILKIWVFNSDLRITNGSFYTSDVNISNKTYNKFPGVRVMKVFYMLIQDTNIKLNFNNISFHSEMVESLLYSLKKSNSLIPESMRQFDIWNIGYLKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7PD24</accession>
    <name>M7PD24_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mitochondrial inner membrane protease ATP23</fullName>
            <ecNumber evidence="8">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00207</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Has a dual role in the assembly of mitochondrial ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
            <topology evidence="1 8">Peripheral membrane protein</topology>
            <orientation evidence="1 8">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="8"/>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872075.1">
        <property type="nucleotide sequence ID" value="XM_007873884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PD24"/>
    <dbReference type="STRING" id="1069680.M7PD24"/>
    <dbReference type="MEROPS" id="M76.A02"/>
    <dbReference type="GeneID" id="19893905"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00207"/>
    <dbReference type="eggNOG" id="KOG3314">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079125_0_0_1"/>
    <dbReference type="OMA" id="KRHHQTC"/>
    <dbReference type="OrthoDB" id="285308at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019165">
        <property type="entry name" value="Peptidase_M76_ATP23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711:SF0">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE ATP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09768">
        <property type="entry name" value="Peptidase_M76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 8" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="228" mass="26884" checksum="019B6ADE19CEC16A" modified="2013-05-29" version="1">MENIHENVSEGSDNIDKSFLSWRNTLMYVLGFGMDKNGRKKYEKIRDHVYKEQMNNRCEEWKRYLFKNSPSVRFIAKHLDSLKSGLSLNDILCVPCDEMKSGWFDSSKGIFLCQNKIWSKSHMEDTLVHEMIHAYDHAKFVVDKNNLRHHACSEIRAVSLSGECRWWREFKNGTIATFRKHHQECVKRRAILSVMGHPACKDMDHAKQVVMQVFEPCFADTRPYDEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7PD34</accession>
    <name>M7PD34_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bax inhibitor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_03204</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875267.1">
        <property type="nucleotide sequence ID" value="XM_007877076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PD34"/>
    <dbReference type="STRING" id="1069680.M7PD34"/>
    <dbReference type="GeneID" id="19896891"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03204"/>
    <dbReference type="eggNOG" id="KOG2322">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058671_0_0_1"/>
    <dbReference type="OMA" id="FGVMSLY"/>
    <dbReference type="OrthoDB" id="7933078at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF50">
        <property type="entry name" value="PROTEIN LIFEGUARD 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="31953" checksum="9DFCE052B523739F" modified="2013-05-29" version="1">MFDKSSKAFIKQDPLPPDYGTSRPYDKGFGEIMFDGYAPLLDQHHIIQENEIPEDFKYGTTVNQCDISIRMDFVRKVYSILFLQIVGSVLVSGVLTTNKMLREYIVSNPVIIFFSMFGSINTLLFLSWKSRSCPLNFYLLVLFTLFESSTIGTIVSYYNSNVILEALLITTGIFLGLTLFTWQSKYDFRSIGGYLYFGLIVFLSGGLVSFFLPYNRTFDLLYAMFGALIFIGYIFYDTSNLMKHLSPEEYIAGAVSLYIDIINLFFQILSLIAKLNGDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>M7PD36</accession>
    <name>M7PD36_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="16">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PNEG_00217</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 16">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="16"/>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872085.1">
        <property type="nucleotide sequence ID" value="XM_007873894.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7PD36"/>
    <dbReference type="GeneID" id="19893915"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00217"/>
    <dbReference type="eggNOG" id="KOG0206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000846_3_0_1"/>
    <dbReference type="OMA" id="MHSFWSW"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990530">
        <property type="term" value="C:Cdc50p-Drs2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140345">
        <property type="term" value="F:phosphatidylcholine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090555">
        <property type="term" value="F:phosphatidylethanolamine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140346">
        <property type="term" value="F:phosphatidylserine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000026">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000126">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000014">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="472"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1029"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1072"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1106"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1137"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1176"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="167"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="18">
        <location>
            <begin position="958"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="13">
        <location>
            <position position="544"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="544"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="544"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="545"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="546"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="546"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="636"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="677"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="700"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="733"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="813"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="814"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="815"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="906"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="912"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="932"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="935"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="936"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="936"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMR11790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1288" mass="147975" checksum="BC6375483395BB1B" modified="2013-05-29" version="1">MNKKSSNCCKQEESMILEQSSLEFGEMAMNGESSTLDHIIIQGSEGQDLTISDSRDISCSESEDDNYTLLHDSIQTKKVYKWIFRYFKIKNIINYIKTRQNIFNSKQTSTPFPTVEPIFNDECQKIMRKKGNTFKSILGVFDFRNKRFATFFNKQSFHNTNSNYRVINFNNNLKNTSYNYCSNYVSTTKYNIATFLPKFLFEQFSKYANLFFLFTSCIQQIRNISPTNRWTTIVPLLIVLIVSAFKELVEDFKRRLQDKELNQSLTYVFEKMSFIPRKWYDLHVGDIVRVESGQIFPADLILISSSEPEGLCYIETSNLDGETNLKIKQSHPETANFISPTKISQLSGEIHSEQPNNNLYSFEATIIINTDIEKKEYPLTEDQLLLRGAFLRNTSWIYGIVVFTGHETKLMKNTTSSCIKQTAVEKTVNIQIIFLFCMLITLSLISSIGLVIKENLHQKNLSYLHFQEKNKMKAFFSNILTFCVLYSNLVPISLFVTIELVKYAQAQLINNDIDMYYEREDIPSTCRTSNLVEELGQVEYIFTDKTGTLTCNQMEFRQLSIAGISYMDNSKKKQSLNSYQKNDVFDFIQLNKNLVSHESKDIIHNVLVLLATCHTVIPEKVDGQDDIIYQAASPDEGALVKGASKLGYIFTTRRPKSVFVSIQGEEQEFKVLNICEFNSARKRMSVILRCPDGKIRLYCKGADTVILERLSKNSLYSEQTLQHLEDYAVGGLRTLCLAMREISEKEYEKWAVIYDEATITINNRTDALDKASELIEKELLLLGATAIEDKLQEGVPETIHTLQLAGIKLWVLTGDHQETAINVGISCKLITEDMNIIIINGRNKKEISNYITKKLAYVKNRQANKARLEALALIIDGHSLTYALEKDIEKKFINLSILCKTVICCRATPLQKALIVTLIKKHLKATLLAIGDGSNDISMIQSANIGIGISGTEGLQAARSADIAIGQFRYLKKLLLVHGTWSYQRLSKLILYSFYKNISLHMTQFWYTFHNGFSGQVIFESWTISFYNVFFTFLPPIAIGIFDQFLSAKLLSKYPQLYRLGQFKTFFNVKNFWLWIANGFYHSLILYFMSIYIFENDLPQADGKIGGHWVWGTTLYAAVLATVLGKAALITDSWTTYTVLAIPGSFIIWIIFLPIYAIVAPKIGVSMEYHGINSRLYTSLVFWATILVLPILCLLRDFAWKYYKRTYCPQTYHYIQEIQKFNTIDYKSKMELFQKTVRKVRNVQRISKLQRGYAFSQGDTGQTKLIRAYDTTQERGQYGEVKYQCQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7PFI4</accession>
    <name>M7PFI4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor BYE1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02555</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Negative regulator of transcription elongation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BYE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874568.1">
        <property type="nucleotide sequence ID" value="XM_007876377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PFI4"/>
    <dbReference type="STRING" id="1069680.M7PFI4"/>
    <dbReference type="GeneID" id="19896247"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02555"/>
    <dbReference type="eggNOG" id="KOG1634">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1844">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009292_0_0_1"/>
    <dbReference type="OMA" id="AWISCET"/>
    <dbReference type="OrthoDB" id="79252at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001139">
        <property type="term" value="F:RNA polymerase II complex recruiting activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15550">
        <property type="entry name" value="PHD_MLL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21538">
        <property type="entry name" value="SPOC_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012921">
        <property type="entry name" value="SPOC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR BYE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07744">
        <property type="entry name" value="SPOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS central" evidence="8">
        <location>
            <begin position="232"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="74"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="396"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="771"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="419"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="771"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="794" mass="90361" checksum="CEB5B25F945401D8" modified="2013-05-29" version="1">MHERVRCICKAVNDDGCIMVQCEQCTTWQHILCMGFLNEESLPETYFCEKCQPDLYPQLQKDNVQGTVSKIKAMERKANNRSNKTSQTKKGQENSKETSKKVLSKGHLKKQSNEKSNETTTIIEEVSEEHQKTLDESFEEENSDSKQKTPSPSTSDSDYNSQEDQKEPPAKVSRLSHDQSFIKALHGRKTNTTLKHSKQMNPPVLKQTFSHVPIEAPVQKLEELKDVTRKHVSQSFLNIFVEAIKDFVKDGSYVLGTNETPEEVGERFALMIEYSMFKDFSIEEKGKYILTPKYKERFRTLHFNLKDDKNPQLRARVVLGQIMPKDLVHMTSEEMANSEIQLLAESIRAQSTKNSVLKQSEAPRIRKTHKGEEIIENQEISGFSMQQKIETSIPFSLKPQNEPTNDLDESSALSQKHNSIHEKSKTISKTHESDIEKNKIKNDKKEATSKESFNIQDVWSNIESQRTTHISENYPVVQSQETSRIDFDSDIDRMIDDDNDNANTPPYSPSYSAFELNISQPIWLGKLSMASIAEFNATATQVVGATISPTRPWNEILQDKIVIDGRISMDKSTEYLCQQKFSSTKELIVISFKPQSKELLSSFEKLYNYFYSRKRYGVIKPTTSAVKDAYLIPLSPTDQLPEFIQLMDEIHISNEKRTEKCIFGVFVVNKISNTVPPVNKIPYHPQNTNEWKKLNNTPLIHQGTGIPAPITPLPTVPILGGLTLPNNLSLSNADMAILQSILSANPGILSNPELISNSKILQQLVIQHQNQHSQINTSHSSNPRPMASRWDKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M7PGI8</accession>
    <name>M7PGI8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874141.1">
        <property type="nucleotide sequence ID" value="XM_007875950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PGI8"/>
    <dbReference type="STRING" id="1069680.M7PGI8"/>
    <dbReference type="GeneID" id="19895853"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02160"/>
    <dbReference type="eggNOG" id="KOG0715">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1147592_0_0_1"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053025">
        <property type="entry name" value="Mito_ATP_Synthase-Asso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44873">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44873:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="42"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="242" mass="29409" checksum="AEC6B0EB74C96039" modified="2013-05-29" version="1">MKSQILRSKTAHSKCFIQLRVAGQISKDKFHIYPFFKRFFSSYYDILEVPKDASYITIKHKYYELSKKFHPDLHKNDKETYKKFLKIKEAYEVLSNKIKRKEHDEKIGISEKNYSDLSEALRKTNYNRLDEKIQKNKENSGYSSEEIYENNSKYYQKSQENLYVNTQFDYEAHYEPYYTYERHRIKRIKKRNEFFDPRGNPCFTNFFCVSTIILIVILLSSFLRFNMNKKSRKHYSFTKPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7PGX5</accession>
    <name>M7PGX5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinate dehydrogenase assembly factor 2, mitochondrial</fullName>
            <shortName evidence="4">SDH assembly factor 2</shortName>
            <shortName evidence="4">SDHAF2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01896</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with the flavoprotein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SDHAF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873870.1">
        <property type="nucleotide sequence ID" value="XM_007875679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PGX5"/>
    <dbReference type="STRING" id="1069680.M7PGX5"/>
    <dbReference type="GeneID" id="19895590"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01896"/>
    <dbReference type="eggNOG" id="KOG3326">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103054_0_1_1"/>
    <dbReference type="OMA" id="DTEIMRM"/>
    <dbReference type="OrthoDB" id="284292at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.250:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase assembly factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.250">
        <property type="entry name" value="Flavinator of succinate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03057">
        <property type="entry name" value="SDHAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005631">
        <property type="entry name" value="SDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036714">
        <property type="entry name" value="SDH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028882">
        <property type="entry name" value="SDHAF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469">
        <property type="entry name" value="PROTEIN EMI5 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03937">
        <property type="entry name" value="Sdh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109910">
        <property type="entry name" value="YgfY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="134" mass="16046" checksum="739F1630FA25DDEC" modified="2013-05-29" version="1">MHHSFFFKNIQWQHRYLHWQASSKHTLSVFLSSSNHGESIETMKARLLYQSRKRGILETDLLLSTFAKKYLPLFKREELETYDKLLKESDLDIYSWIIGKAETPDRWNKNSLFLTLKSHCQDKTVLIRRMPDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7PHG4</accession>
    <name>M7PHG4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873616.1">
        <property type="nucleotide sequence ID" value="XM_007875425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PHG4"/>
    <dbReference type="STRING" id="1069680.M7PHG4"/>
    <dbReference type="GeneID" id="19895349"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01655"/>
    <dbReference type="eggNOG" id="ENOG502RS0H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_4_0_1"/>
    <dbReference type="OMA" id="TDHEGTA"/>
    <dbReference type="OrthoDB" id="368909at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120114">
        <property type="term" value="C:Sm-like protein family complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06168">
        <property type="entry name" value="LSMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034110">
        <property type="entry name" value="LSMD1_Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF5">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 38, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="1">
        <location>
            <begin position="2"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="76" mass="8739" checksum="2C844A5314987087" modified="2013-05-29" version="1">MKGKKILETWLLKIVRVTLSDSRIFIGKFVCVDKDGTMILSNTQEFNKEKKRSIGLVVLPGKNIIRFEICTQEIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7PHK0</accession>
    <name>M7PHK0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_01693</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the activator 1 small subunits family. CTF18 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873656.1">
        <property type="nucleotide sequence ID" value="XM_007875465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PHK0"/>
    <dbReference type="STRING" id="1069680.M7PHK0"/>
    <dbReference type="GeneID" id="19895387"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01693"/>
    <dbReference type="eggNOG" id="KOG1969">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004894_3_1_1"/>
    <dbReference type="OMA" id="RWLKGWE"/>
    <dbReference type="OrthoDB" id="2195431at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053016">
        <property type="entry name" value="CTF18-RFC_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46765">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46765:SF1">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="579"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="642"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="266"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="736"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR09934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="840" mass="98600" checksum="0072F644DFEAF310" modified="2013-05-29" version="1">MDLDDRISIQNKENITYKNYEKLYDDICNSQKDILDKNNEESSMNMKKIDLDRLKVANPLLLDGFKLEFITQNASREEAMHNLDIVSDEMENKNISFNKMILEEDTGLNENALFQKDIFTLKLDNQYNNSFKYERSINNKCIFACTSYGKVIRFNKKYKKLKKSNFINNNDYYGIPIHKLANFSKNSEEIFDYNDYNFTSPIESQLWTKKYAPKKFADLIGDDRIHREVLRWIKHWDFCVFSKYLPQNKIFEKEEESNYDFLKRPKQKILMLAGTPGLGKTTLAHIAARQAGYNVIEINASDDRTGAVVRNQISNVLDIRSIHSSCPTLIIIDEIDGVSNSTSEQGFIKSLVDILIEDDHATKELVYKKSETYSKRSKTKSKKRILLRPIICICNDLYTAALRPIRQYSKIIYFKQIPTSSLVSRMDTICKIEGLSADMQALTTLCEIFENDFRSCINSLQFYKTYGIDLTSGSLDTFKNKLKKDPSKNLNLVLDKIFFSNSKNYKNEYISDNRAMFVDLYETIQNYGDYEKLINNCFMRYLSQDYKDDQLSKPILAGDWLFFFDILNRSIYEKQNIELLSYLAFPLLIFHILFISVKKDYYRNYQQNTKQISDWELYESEKINKEICASLYYGSAPYLQQVLCIDILLIDVVPYLIYILLPTLNPVNLRSIKNTEKHILNRVVNSMIHFNINYVQMKANDGTFFYKFEPSIETLVTFSFLKRHEPIFLKYSVCHIINLELENEKRRIQKERYNKNLNELSNIPPVNKRKFDEPLDAESVVIKDFFGRAISKDINNKNPKNFNHRNKQILLKPKAKVWVKFHEGYSNAVKKSISIEDILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7PHP8</accession>
    <name>M7PHP8_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01742</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873706.1">
        <property type="nucleotide sequence ID" value="XM_007875515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PHP8"/>
    <dbReference type="STRING" id="1069680.M7PHP8"/>
    <dbReference type="GeneID" id="19895436"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01742"/>
    <dbReference type="eggNOG" id="KOG2627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_809230_0_0_1"/>
    <dbReference type="OMA" id="TEYHEER"/>
    <dbReference type="OrthoDB" id="19679at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019148">
        <property type="entry name" value="Nuclear_protein_DGCR14_ESS-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940">
        <property type="entry name" value="ES-2 PROTEIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940:SF0">
        <property type="entry name" value="SPLICING FACTOR ESS-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09751">
        <property type="entry name" value="Es2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="343" mass="39396" checksum="E09F021E3E320D68" modified="2013-05-29" version="1">MKKEETINEKDDLKCIPKNAIEKAYKRPLIKKKRIPHVLEEDTYQATLSEIIKRDFFPDLLENDSKDILSSLCNPNLSLDEFQATYTSEDNASFTDILERQNERQRDAYRWLWDNRNKIDSKRVKEAERRQISSENNIISIEERPAQPEAWPFNPMNTLMFTPETDYTKPKSLPSNGEKSIVYHATRMPLESQEYIASPSFSAIDKEPEVAGWTFVDEAPTPSPEILKKSRKLGKEMESSSIGIPETPGRAFKMPDIPAREILHHRITEQIKKKKRAKTPAAFLKEIPKFSSSPDLRKVMLTPGGRFLLAATQRHASAIRNDLKTPRMSLLNNVTTNITPRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M7PI33</accession>
    <name>M7PI33_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873338.1">
        <property type="nucleotide sequence ID" value="XM_007875147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PI33"/>
    <dbReference type="GeneID" id="19895099"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01402"/>
    <dbReference type="HOGENOM" id="CLU_1338002_0_0_1"/>
    <dbReference type="OrthoDB" id="5390221at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="205" mass="23686" checksum="8CD420DD98C1BA10" modified="2013-05-29" version="1">MECELYGSCCLFRWLRRFYQRIKDRQTEKKFQAGMKYSEYGTQMENELTRTSKKAEHISDIVVYRYREKNDIQDDEKKETLSYEQTSFPQEKMTEMRVLPNNALTGFQSLETDQLSCGIITFPEAKSIDPSSHFVSYAASDDTISFTHLSNNKYVQDRCRISMDTNASIRALAPSRQSSYSSLSSAWTGSKLGLSFLSEAMMMVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>M7PIC3</accession>
    <name>M7PIC3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Histone deacetylase</fullName>
            <ecNumber evidence="2 10">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_01482</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2 10"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873421.1">
        <property type="nucleotide sequence ID" value="XM_007875230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PIC3"/>
    <dbReference type="STRING" id="1069680.M7PIC3"/>
    <dbReference type="GeneID" id="19895178"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01482"/>
    <dbReference type="eggNOG" id="KOG1342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007727_7_4_1"/>
    <dbReference type="OMA" id="RCHTDEY"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031078">
        <property type="term" value="F:histone H3K14 deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032129">
        <property type="term" value="F:histone H3K9 deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140937">
        <property type="term" value="F:histone H4K12 deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034739">
        <property type="term" value="F:histone H4K16 deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180032">
        <property type="term" value="F:histone H4K5 deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180033">
        <property type="term" value="F:histone H4K8 deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="14">
        <location>
            <begin position="22"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR10209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="390" mass="44408" checksum="F2BF3E4539F2CFF3" modified="2013-05-29" version="1">MHKTVSYFYDPDIGNYHYGANHPMKPHRMRMTHSLVLSYGLYKKLDMTVPKRATRKDMTRCHTDEYVDFLWRVTPDTMEKFILHQSRFNVGEDCPVFDGLFEFCSISAGGSICAAQKINTGDSNIAINWSGGLHHAKKREASGFCYVNDIVLAILELLKYNQRVLYIDIDIHHGDGVEEAFYTTDRVMTCSFHKYGEYFPGTGSIEDIGIGKGKNYSVNIPLKDGIDDKSYESVFKPIIQRIMDWYRPNVIVLQCGADSLAGDRLGCFNLSMKGHAECVRFVKSFNLPIVAVGGGGYTIRNVARAWTYETAVLIDETLDENIPFNSYLDYYGPEFKLDVPSNNMENQNSRTYLENITSKVIDNLRNISHSPSVQIQHIPSDFLFEDENNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJN3</accession>
    <name>M7PJN3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01369</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873298.1">
        <property type="nucleotide sequence ID" value="XM_007875107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJN3"/>
    <dbReference type="STRING" id="1069680.M7PJN3"/>
    <dbReference type="GeneID" id="19895066"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01369"/>
    <dbReference type="eggNOG" id="ENOG502T4IT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1378655_0_0_1"/>
    <dbReference type="OMA" id="IEATHLI"/>
    <dbReference type="OrthoDB" id="249612at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019335">
        <property type="entry name" value="COG7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21443">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21443:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="198" mass="23191" checksum="541946DFCB1FC934" modified="2013-05-29" version="1">MQSNTNETNPSLSSLSYLPSIYINSFLSSTISLEEAKNITTSLLSSLEFESRSTINQLQEIVNEIIQQLPQLSYDIELLHNDIVVLLEILNKKKEYAETLKKGTENHVIDNFLHLDLIKKRIEATHLILKEAKEWKNIETKKKHIELLIKNKKFQEAQNIVNKLKRLVKVWKETNEYNERLDMIKVLEQKIPDFTEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7PK51</accession>
    <name>M7PK51_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein bS18m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00961</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872874.1">
        <property type="nucleotide sequence ID" value="XM_007874683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PK51"/>
    <dbReference type="STRING" id="1069680.M7PK51"/>
    <dbReference type="GeneID" id="19894659"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00961"/>
    <dbReference type="eggNOG" id="KOG3162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082177_1_0_1"/>
    <dbReference type="OrthoDB" id="21463at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_bS18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_bS18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_bS18_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479:SF40">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS18M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="173" mass="20163" checksum="B06AA36A57088007" modified="2013-05-29" version="1">MLEFVLISIDLKDPKILEQNAPNEKRTLDTQLHDSNDPNVKVPTKTGLLKIPKTFYTPFKDSQLYSPYDLSFEKNLAYRYSLNNVKEDTWKRLCISPLKQYKSFNVLSEFITEMGRILPRDETGCSAKHQRQLAKAIRRCRGIGLLSTTQRHPTYLESKRKYYMNKKGAIEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7PLA4</accession>
    <name>M7PLA4_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872146.1">
        <property type="nucleotide sequence ID" value="XM_007873955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PLA4"/>
    <dbReference type="STRING" id="1069680.M7PLA4"/>
    <dbReference type="GeneID" id="19893973"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00275"/>
    <dbReference type="eggNOG" id="KOG2354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055683_0_0_1"/>
    <dbReference type="OMA" id="NCHASIK"/>
    <dbReference type="OrthoDB" id="340681at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006886">
        <property type="entry name" value="RNA_pol_III_Rpc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES III 80 KDA POLYPEPTIDE RNA POLYMERASE III SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04801">
        <property type="entry name" value="RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="267" mass="31228" checksum="A2998BD5753CB8CC" modified="2013-05-29" version="1">MKLRESIKNPSLTLLDEDPIIKTYNIYISSYLNDNLYLFQYPIRPSSQPYIEESLSKPLELRIKPKSGIVEIDVPIHTKQYYNEERGIKFSKNLENNFSEDKYSILNFQTLSSKISPCRNYYMVGIIRGDELHLSPVNYTLQLRPSFKHLNNFSTIKETSMTEFHPASNMSTRAIQTSAKSSESSETLALSTTHILRSIESEPWINLIWIDSSSIMAKKIFQHLYCNNTDNFIQRYYSKKDYLSDISVFQSNHTENDPKRIFFKKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>M7PM83</accession>
    <name>M7PM83_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication licensing factor MCM2</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">DNA replication licensing factor mcm2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Minichromosome maintenance protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PNEG_00028</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871879.1">
        <property type="nucleotide sequence ID" value="XM_007873688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PM83"/>
    <dbReference type="STRING" id="1069680.M7PM83"/>
    <dbReference type="GeneID" id="19893726"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00028"/>
    <dbReference type="eggNOG" id="KOG0477">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000995_0_1_1"/>
    <dbReference type="OMA" id="TYERVTT"/>
    <dbReference type="OrthoDB" id="844at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006267">
        <property type="term" value="P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17753">
        <property type="entry name" value="MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000138">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008045">
        <property type="entry name" value="MCM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF44">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12619">
        <property type="entry name" value="MCM2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01658">
        <property type="entry name" value="MCMPROTEIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="19">
        <location>
            <begin position="450"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00078186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMR11584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="805" mass="91537" checksum="35C4C5BAC0F40FFA" modified="2013-05-29" version="1">MSELPFSLPPSSPPMLSGFDISENEALIDDMVDNLDDAAEEEDGEDLFGENMERDYVQNIELDHYDIDELDDEEEYEAMDPALRREVEEKLRRRDRELEKAKGLHKTTAFLQDDENDSLDFSIRRRRRHYYDDKQDDMNEEFVEELTLDALMDIKADSINEWILMDPVQNAISREFRTFLLEYTDDKGTSVYGNRIRTLGEINSESLEINYTHLLESKAILAYFLVNSPSELLSIFNRVAMETTLLHYPDYERIHSEIHVRIIELPKTFTLRELRQSHLNCLVKVSGIVTRRTGVFPQLKYVKFDCQKCGIVLGPFSQDSNTEIKIGFCHNCQSKGPFSLNSEKTIYRNYQKMMLQESPGTISPGRLPRHREVILLWDLIDSAKPGEEIEVTGIYKNNFEASLNVKNGFPVFATVIEANHISKTYDQFAAFRLTEEDEKAIRQLSKTENIDKKIIASIAPSIYGHYDIKQAIACSLFGGVPKDINGKHSIRGDINVLLLGDPGTAKSQFLKYVEKIAHRAVFATGQGASAVGLTASVRKDPVTGEWTLEGGALVLADKGVCLIDEFDKMNDRDRTSIHEAMEQQSISISKAGIVTTLQARCAVLAAANPIGGRYNTTIPFNQNVELTEPILSRFDILNIVKDTVDPEEDERLAKFVIGSHLRSHPYYSPNAENLIDHKQPMGAIEPIPQDLLRKYIMYAREYIHPKLHQIDQDKISKLYSDMRRESLATGSYPITVRHLESIIRISEAFAKMHLSEYVKTQHIDSAIKVIVDSFISAQKLSVKKSLSRALAKYILPKSNRVPIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7PMJ1</accession>
    <name>M7PMJ1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TAFII55 protein conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00125</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871984.1">
        <property type="nucleotide sequence ID" value="XM_007873793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PMJ1"/>
    <dbReference type="STRING" id="1069680.M7PMJ1"/>
    <dbReference type="GeneID" id="19893823"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00125"/>
    <dbReference type="eggNOG" id="KOG4011">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016434_3_0_1"/>
    <dbReference type="OMA" id="NESDEHH"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55 protein conserved region" evidence="7">
        <location>
            <begin position="62"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="296"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="306"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR11689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="383" mass="44271" checksum="4FD43DBDD777E180" modified="2013-05-29" version="1">MLKIKVKLGGGSEKKPIQPKLRAKSPGQSQLNSGTKIRLRAYRESGLGYDSEASDREDDPYIEQQFILRMCNGEDLEYLRKAVEEKTIGNGADFYIKFKDNRRAIVVVNNHMYSAKMADLPCIIESSKTFDRKTIYKVADICQILLVENRIDDEETVTTMPIKHSEYIYPHGLTPPLKWVRKRRFRKRLSHKTIEMIEAEVTRLLSLDAMAELSSYEVIPASLLSRENSFVLENESLFDTSKNLYKKEEYYENVNTMDIESEHYDDADEDYLADQLEQAMMELDNREASQTPAFIKETETPQDGSGSDDNEDSSEEIDEETRWAEDHQRLLDDEIAELNATIAANLEKLKTTTNPILQKRFEDIIRKLKSELDLKQSQNDKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZX04</accession>
    <name>A0A0W4ZX04_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_04298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="KTW32894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613368.1">
        <property type="nucleotide sequence ID" value="XM_019757817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZX04"/>
    <dbReference type="GeneID" id="30671584"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04298"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KTW32894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="73" mass="8810" checksum="B6A338BE7590BC3C" modified="2016-03-16" version="1">MEYAFLFDSALIIYCIKKIQFFYNFIFKICRNITCEEYVCSWEDDQCLELIIAKGIMKELSAQYKGFSWLHEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJ00</accession>
    <name>M7NJ00_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875115.1">
        <property type="nucleotide sequence ID" value="XM_007876924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJ00"/>
    <dbReference type="STRING" id="1069680.M7NJ00"/>
    <dbReference type="GeneID" id="19896746"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03059"/>
    <dbReference type="eggNOG" id="KOG1470">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016665_2_0_1"/>
    <dbReference type="OMA" id="WMDPVVA"/>
    <dbReference type="OrthoDB" id="43460at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120010">
        <property type="term" value="P:intermembrane phospholipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052432">
        <property type="entry name" value="PITP/CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="153"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="401" mass="47651" checksum="242CC93BEC5E7BE3" modified="2013-05-29" version="1">MVAIDKKLDELTRNEEKALKCFWLFVLLHFKKINREDLGEYVILNEESHGFGKKCEIFLKNSEEMGGIDDNNVSKKLLRERHILNYFFALYDVFWEMIKMDHPDAVLLRFLRARKWDISKSFVMLAATVYWRQETGVEEVLRTGEAGAIETGDDAFMKQLRLGKSFIQGVDREHRPICYIRTHLHRAGEQPDLAIQRYIIWLMESARLMITYPVQTATILFDLTKFSLKNMDYIPIKFLIKCFEAHYPESLGICIIHKAPWVFQGIWKVIKTWLDPVVAKKVCFTNSRKDLEVYIKDTEIIKELGGKKDWEYRYIEPQENENIKMQDILTKERLSLQRKNIIHSFEQLTIKWLKENDTVQSDLLLEQRNFIARDLSLNYWQLDPYIRARSFYDRIGLIFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJ09</accession>
    <name>M7NJ09_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L34-B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_03069</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875125.1">
        <property type="nucleotide sequence ID" value="XM_007876934.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJ09"/>
    <dbReference type="STRING" id="1069680.M7NJ09"/>
    <dbReference type="GeneID" id="19896756"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03069"/>
    <dbReference type="eggNOG" id="KOG1790">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118652_1_1_1"/>
    <dbReference type="OMA" id="RCHKCVR"/>
    <dbReference type="OrthoDB" id="277449at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.370.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_eL34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038562">
        <property type="entry name" value="Ribosomal_eL34_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018065">
        <property type="entry name" value="Ribosomal_eL34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46595">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01199">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01250">
        <property type="entry name" value="RIBOSOMALL34"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01145">
        <property type="entry name" value="RIBOSOMAL_L34E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="13171" checksum="BFCE9D0D4389F080" modified="2013-05-29" version="1">MQRLTYRRRLSYNTPSNKVRVIKTPGNKLKYLYVKKKGKPPRCGDCYHALQGIPAVRPRVYSRLSKNKKSVSRSYGGSRCSRCVKDRIMRAFLIEEQKIVKRVLKTQIRLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJC2</accession>
    <name>M7NJC2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fcf2 pre-rRNA processing C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02891</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874928.1">
        <property type="nucleotide sequence ID" value="XM_007876737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJC2"/>
    <dbReference type="STRING" id="1069680.M7NJC2"/>
    <dbReference type="GeneID" id="19896578"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02891"/>
    <dbReference type="eggNOG" id="KOG3100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1279138_0_0_1"/>
    <dbReference type="OMA" id="QLTEGWF"/>
    <dbReference type="OrthoDB" id="427886at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039883">
        <property type="entry name" value="Fcf2/DNTTIP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014810">
        <property type="entry name" value="Fcf2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686:SF12">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08698">
        <property type="entry name" value="Fcf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fcf2 pre-rRNA processing C-terminal" evidence="4">
        <location>
            <begin position="140"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="259" mass="30634" checksum="FFC5E93AAC7ED6C0" modified="2013-05-29" version="1">MSNEVVYYGKNLDVLKNSLLNSFNNSNISEKKTTEMVNLEIHSQENIEYLLKRAQENLEKLSKELPVSEKTKDSKDIQNSIAALSDHHNIEPKYISTVGNVSSLNSTVFEKSYKVIYDDVNHIIEHKPLLSKKEKRKKQEETAGKDWFYMPKPELTQSLKTELQILKMRNVLDPKRHYRKDNSKKPPKYFQIGTTIDDVLNTPMEDFFKKKTNTILDEILEDQDKRQYFKRKYQDIQKIKTSGKKAYYKKLKEKRKPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJW0</accession>
    <name>M7NJW0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Scaffold protein Nfu/NifU N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NifU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874714.1">
        <property type="nucleotide sequence ID" value="XM_007876523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJW0"/>
    <dbReference type="STRING" id="1069680.M7NJW0"/>
    <dbReference type="GeneID" id="19896381"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02690"/>
    <dbReference type="eggNOG" id="KOG2358">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060555_0_2_1"/>
    <dbReference type="OMA" id="MAAHVRW"/>
    <dbReference type="OrthoDB" id="565552at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000001">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.70:FF:000001">
        <property type="entry name" value="NifU-like protein 4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035433">
        <property type="entry name" value="NFU1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036773">
        <property type="entry name" value="HIRIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="2">
        <location>
            <begin position="36"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="232" mass="26205" checksum="58903CBAD8E1EF7C" modified="2013-05-29" version="1">MSRNTLLRFSFNSKPILSSFYPELSFLKCKKRSIWIQSEKTPNENAIKFIPGVNILPESLTSIEYLNSHQATSSPLAKKLFAIDGVKYVFYGPNYITITKHSKNAWSPLKPEIFSIIMEHISSGQPIFLPETQDLGSNVNTEDDSEVVSMIKELLETRIRPVIQEDGGDVEYRGFDNGKVFLKLKGACKTCDSSVITLKNGIENMLMHYIPDVKGVEHVMDKDEEVGIKVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>M7NK59</accession>
    <name>M7NK59_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein kinase RIO1</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Serine/threonine-protein kinase rio1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PNEG_02791</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 21">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874823.1">
        <property type="nucleotide sequence ID" value="XM_007876632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NK59"/>
    <dbReference type="STRING" id="1069680.M7NK59"/>
    <dbReference type="GeneID" id="19896480"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02791"/>
    <dbReference type="eggNOG" id="KOG2270">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018693_4_0_1"/>
    <dbReference type="OMA" id="HPMSLDF"/>
    <dbReference type="OrthoDB" id="205248at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05147">
        <property type="entry name" value="RIO1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000148">
        <property type="entry name" value="Serine/threonine-protein kinase RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017407">
        <property type="entry name" value="Ser/Thr_kinase_Rio1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038147">
        <property type="entry name" value="Ser/Thr_PK_RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="23">
        <location>
            <begin position="44"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="401"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="19">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="19">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EMR09017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="438" mass="51939" checksum="0BFFA74C8298732A" modified="2013-05-29" version="1">MHVIEANSQNLSNFETIDVLNKYMNRLNFEDYFPCDEKVKISKDKSDRATTEQVLDLRTRIILFKLINKGIIYKINGCVSTGKEANVYHAVTESGEQRAIKVYKTSILIFKNRDRYVSGEYRFRHNYCRHNPRKKVELWAEKEMRNLKRLYQAGIPCPEPLYLRMHVLVMSFLGGNDSWPYPRLKDANISSNKYPDLYFQLLCYIRIIYQVCHLVHSDLSEYNILYHSKVLYIIDVSQSVEHNHPRSLEFLRMDITNVNDFFRKNGVICFNAKAIFDFVISDSGGTTKEEIEKTLIEMQSLEEFQESVDFKEDIVFKYSYIPQTLKQVDDEEKDIELINRNEDGLLYKRLINISSESKTDSDIESDYFDKTDSILDDDFNKNDESRSNLLRLKRFEDKNVKKERKTQVKELNKERRKHKMHKAEKKQKIKASKKRKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NKB9</accession>
    <name>M7NKB9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02429</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874435.1">
        <property type="nucleotide sequence ID" value="XM_007876244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NKB9"/>
    <dbReference type="STRING" id="1069680.M7NKB9"/>
    <dbReference type="GeneID" id="19896122"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02429"/>
    <dbReference type="eggNOG" id="KOG2210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012334_4_2_1"/>
    <dbReference type="OMA" id="RYDYPNG"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000007">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000001">
        <property type="entry name" value="Oxysterol-binding OBPalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF102">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="319"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="51711" checksum="66F38C380E633DD0" modified="2013-05-29" version="1">MNDILLPKHTTFKHKKKDKEDHDSEHLGREGTNIILGIISQLKPGMDLSRITLPTFVLEPKSMLERITNFMCHPELLLDIPFIDDPIERFIGICRFYLSGWHIRPRSVKKPLNPILGEHFTCKWEFPDKSEALYIAEQVSHHPPISAYFYMSPENNVRIDGVLKPRSKFLGNSAGTIMEGKAILTFINRNEEYILTQPNMYARGILFGRLRFELGDHSYIKCNKNDLIADIEFKTKGFLSGTYNVILGKIKYESNGEVLYEISGKWDEEMTIKNVKTGKRVVLFDATNSSYTQPIVRPEYEQEDRESRKLWSKVIDAIIRNDQDTATEAKSAIEDLQREEQKLRDAKGEKWIPRFFEKTETDDYILKTKINWTTPDDIKEQIENIITISEKRKPSNEHNESFGFDKVFHSSQMQISSPSSFFTQKVSDDDDFHDAIDCLSIINDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M7NKP8</accession>
    <name>M7NKP8_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_02554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874567.1">
        <property type="nucleotide sequence ID" value="XM_007876376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NKP8"/>
    <dbReference type="GeneID" id="19896246"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02554"/>
    <dbReference type="HOGENOM" id="CLU_1971457_0_0_1"/>
    <dbReference type="OrthoDB" id="5308264at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR09218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="127" mass="14652" checksum="C72A3C12D25C431D" modified="2013-05-29" version="1">MKELDCFDKKECRFTRLYMSAAPEFLIDAAVPTLALQVEELTPILIFPRKTCLDTLSKHSSCSTSESNLCYQNNSLRIQNTMFAESGSSPFFNRFFNIQHNFSEQGYISFPPLDFYSQDKRSSSIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NKU6</accession>
    <name>M7NKU6_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hsp72-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02587</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874602.1">
        <property type="nucleotide sequence ID" value="XM_007876411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NKU6"/>
    <dbReference type="STRING" id="1069680.M7NKU6"/>
    <dbReference type="GeneID" id="19896279"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02587"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_3_0_1"/>
    <dbReference type="OMA" id="AYTKNQD"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000028">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000134">
        <property type="entry name" value="Heat shock cognate 71 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000016">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="619"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="508"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="619"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="634"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="645" mass="70753" checksum="E0ED0D168783B021" modified="2013-05-29" version="1">MAFEKAIGIDLGTTFSCVGVWQNDRVEIIANDQGNRTTPSYVAFSDTERLIGDSAKNQVAMNPSNTVFDAKRLIGRKFGEPEVQADMKHWPFKVIDRGGKPYIQVEFKGESKTFTPEEISSMVLIKMKEVAESYLGKTITNAVITVPAYFNDSQRQATKDAGLIAGLNVLRIINEPTAAAIAYGLDKKTEGERNVLIFDLGGGTFDVSLLTIEEGIFEVKATAGDTHLGGEDFDNRLVNHFVQEFKRKHKKDISGNPRALRRLRTACERAKRSLSSSTQTSIEIDSLYEGIDLYTSITRARFEELCQDLFRGTMEPVEKVLRDAKIDKSSVHEIVLVGGSTRIPRIQKLVSDFFNGKEPNKSINPDEAVAYGAAVQAAILSGDTSEKTQDLLLLDVAPLSMGIETAGGVMTPLIKRNTTVPTKKSEVFSTYSDNQPGVLIQVFEGERPRTRDCHLLGCFDLTGIPPAPRGVPQIEVTFDVDANSILNVSAVEKGTGKTNKIEIKNEKGRLTKEEIERMIQEAEKYKAEDEEEAQRVSAKNGLESYAYSLKNTLSDSKVGDKIGEAEKTKLEKAVADVTSWLETNQTATKDEYSSRQKELEAIAGPIMMKFYQSGDGVPGMGGAYGQPGGFPGATDDHGPSVEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLH6</accession>
    <name>M7NLH6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_03494</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875584.1">
        <property type="nucleotide sequence ID" value="XM_007877393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLH6"/>
    <dbReference type="STRING" id="1069680.M7NLH6"/>
    <dbReference type="GeneID" id="19897181"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03494"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006421_3_2_1"/>
    <dbReference type="OMA" id="WIRESKK"/>
    <dbReference type="OrthoDB" id="1738954at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000313">
        <property type="entry name" value="Serine/threonine-protein kinase srk1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="82"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="540" mass="63465" checksum="A42699861881B977" modified="2013-05-29" version="1">MIEIFRILVDCSKKIHNSLFKHSSRQIYQDFKKITYDHIEKEDEKSICNEFYSGNSTKEIYMNHQKKIIQKNLSQCMSFEKYTLIEKMGDGAHSEVYKAICNETKEYVAIKVIRKYQLNYTQKVNVFKEIRIMQDINHPNILRFLGFLENNDYYFLILELVEGGEIFYQIVRLTYFSEELSKHVITQVAHAIHYLHEEKGVVHRDIKPENILYKPIPFVPRKHAKSKMDMDKADEGEFIQGLGSGTIGQVKIADFGLSKVIWDRQTKTPCGTIGYTAPEIIKDQKYSKCVDMWALGCVLYTFLCGFPPFYDENTQVLSRKVARGEFSFLSPWWDNISKSAQDLVSNLLTVDPKKRYTINQFLNHPWIRESKKEALQDNVSYVSNSLTLNSISSWSYIRDYPTCKEYKNYFRSSDAISLRDVFDISYKIQRMKEESTYQTSVLLDNTFHNNMNISYYIEETIQKKLHSQIYHTVKENIYTPKKHSKHTNEEEKKYNSSLHSLYLSHLHSSTDNFLYDSESCLELLLEKSTLLCRRKALLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLR9</accession>
    <name>M7NLR9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">diphthine methyl ester synthase</fullName>
            <ecNumber evidence="4">2.1.1.314</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02196</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="EC" id="2.1.1.314"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the diphthine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.314" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874180.1">
        <property type="nucleotide sequence ID" value="XM_007875989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLR9"/>
    <dbReference type="STRING" id="1069680.M7NLR9"/>
    <dbReference type="GeneID" id="19895889"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02196"/>
    <dbReference type="eggNOG" id="KOG3123">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066040_1_0_1"/>
    <dbReference type="OMA" id="HNASIMS"/>
    <dbReference type="OrthoDB" id="2516at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141133">
        <property type="term" value="F:diphthine methyl ester synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000004">
        <property type="entry name" value="Diphthine synthase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000004">
        <property type="entry name" value="Putative diphthine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01084">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="287" mass="32381" checksum="32E105E0B155E08E" modified="2013-05-29" version="1">MLYLIGLGLADEKDISVKGLEIIRQCQTVYLEAYTSILYVSKEKLEAFYGCSITLVNREKVEYDGIMLLQEAREMNVALLVVGDPLSATTHVDLLLRARQENVPTQIVHNASIMTAIGAVGLQLYNFGQTVSLVFFTETWKPNSIYFRIKENRDLGLHTLILLDLHVQEPLLESFIKGKKIYKEPLFMSISHAIDQLLELELLCHEKVYDESTLAVGVSRMGSSTEKIVAGSLKQLASVDFGPPLHSLILLGNKIHIMEIEYVREFALDIKIFDSLAQQQFPSLYKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLV2</accession>
    <name>M7NLV2_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_03346</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875426.1">
        <property type="nucleotide sequence ID" value="XM_007877235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLV2"/>
    <dbReference type="STRING" id="1069680.M7NLV2"/>
    <dbReference type="GeneID" id="19897033"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03346"/>
    <dbReference type="eggNOG" id="KOG3056">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039328_0_0_1"/>
    <dbReference type="OrthoDB" id="273123at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040184">
        <property type="entry name" value="Mcm10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055065">
        <property type="entry name" value="OB_MCM10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015408">
        <property type="entry name" value="Znf_Mcm10/DnaG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454:SF11">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22379">
        <property type="entry name" value="OB_MCM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09329">
        <property type="entry name" value="zf-primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MCM10 OB-fold" evidence="9">
        <location>
            <begin position="162"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger Mcm10/DnaG-type" evidence="8">
        <location>
            <begin position="304"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="525" mass="60222" checksum="C6CCD484FD07CDE4" modified="2013-05-29" version="1">MTDFSCSLLKHKTKQSDDRKRFQCQSRNAQNFLSSEETKNKRKRLSNVYVQVPRSPSPVKSLPLSTKNLQSFHERKMDDNISLKKTVHLSVKPSKTFSEKLSDLRSKKKIKENITDMQKRRLSKGFVALNEKNKLVDSEIFSDFQSKENVLSFSSEDPYDSYSMLYLSKRNISHDELSFYFKGKKIFLLPELLKTVTAPTYEFPDHDNDCVVIGIIAYKSIPKHIQNEKKDANIKSRYCVLTLTNLKWEISLFLFDGAFERYWKIQVGYIIAILNPGIMKPKKIDSGNFSLVLSHEYDSLLELGLSRDLGFCNALRRDGKQCTSWVDIRHSEVCGFHVDQGMHKIRNARMEVATGTRLYSPKKSKYISSKVGYSKGPKSAEGLLAEHTGWVHDPWNGNVFMISNFLYGYERDALDAKRAERMRFQHQKQTQESNMVSRLFAYEQVPRNVPDSLEIHAKVTCPISSVSLENSSKLYPEPFSIQSVKRIGFNPYSHSVFPSSSSILPIARSLSSDICCNSDSDLEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLW9</accession>
    <name>M7NLW9_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875445.1">
        <property type="nucleotide sequence ID" value="XM_007877254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLW9"/>
    <dbReference type="GeneID" id="19897050"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03363"/>
    <dbReference type="HOGENOM" id="CLU_729819_0_0_1"/>
    <dbReference type="OrthoDB" id="2392202at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="379" mass="43642" checksum="D34E529B4841A58D" modified="2013-05-29" version="1">MKQGIPILICCIVHLTLGGYFLLIAVRGGPPQVIVFAATAAFLYLQLMIGDAVLLPERGFNMCIVALGTLSIFIGIIFWGWLFFSGNGIAAVNAACVFFPEKRCKPRWSKEFAGFMGLTLWTISAISQVFLYFYFIYNRSPKRSKKLQKSKSHNVLDFSSMSYASHGTPSLTCMSISSTDNDKMIYPMTAISPIYERKISDKAWMLKFYERSLKDQSNITKNSQFCKDLKTQKNHGFSSSRKLRSIRRRKNFGHRHFPLYTTWHAPFCQTRYPYFSKKTPSFLNMKIPLMNLHSSKNRETIVEGPDWNTWDFSNFDMSMYSNSFSQEAISLNDNIYNNESLSALDTLHESFDTQMTQSSCFRRFFEKNLNNMSLNNSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NM12</accession>
    <name>M7NM12_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aminodeoxychorismate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873869.1">
        <property type="nucleotide sequence ID" value="XM_007875678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NM12"/>
    <dbReference type="STRING" id="1069680.M7NM12"/>
    <dbReference type="GeneID" id="19895589"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01895"/>
    <dbReference type="eggNOG" id="ENOG502S7GD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020844_6_0_1"/>
    <dbReference type="OMA" id="RGMIRAK"/>
    <dbReference type="OrthoDB" id="5288718at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050571">
        <property type="entry name" value="Class-IV_PLP-Dep_Aminotrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743">
        <property type="entry name" value="AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743:SF11">
        <property type="entry name" value="AMINODEOXYCHORISMATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="27443" checksum="248B61F6859FA69F" modified="2013-05-29" version="1">MEEISKLKDITQGKEWALLETIFYNGSDFFLLEKHLQRLIKASIYFGWKTIDIKQVEEKLWDSVRSLGSSRVRLTVAQNGTIDIQVSPFISSGNLFGIFSKNGWKMDKPWRVYLDTIPMDDTLRPFFCHKTTYRDPYEAARKRLKIDKEMEVLLYNRYGYVMEGSICNVAFFRNHQWITPSLKEGCLPGIMRETLLQKKYIVEHSIQIYDLIDGERLLLFNSLRGCFQGILCNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMA1</accession>
    <name>M7NMA1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_03172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875235.1">
        <property type="nucleotide sequence ID" value="XM_007877044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMA1"/>
    <dbReference type="STRING" id="1069680.M7NMA1"/>
    <dbReference type="GeneID" id="19896859"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03172"/>
    <dbReference type="HOGENOM" id="CLU_1865969_0_0_1"/>
    <dbReference type="OrthoDB" id="5349059at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="137" mass="16090" checksum="F64851EF6D364165" modified="2013-05-29" version="1">MPCLCSFICFQKHKQVNSPQTADDASIRCYIRKDKPIEQESNEDTSNITCDELLSEAILRKIENDEILQKLINESKPLRDILLEIYEKIPSNNNSPFSVPKFLLDRISELRNYETNNLFLSFIQRVLYLSNQERFNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMA9</accession>
    <name>M7NMA9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase</fullName>
            <ecNumber evidence="5">2.7.8.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GlcNAc-1-P transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">N-acetylglucosamine-1-phosphate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PNEG_01976</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UMP</text>
            <dbReference type="Rhea" id="RHEA:13289"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.7.8.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13290"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.15" evidence="5"/>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873954.1">
        <property type="nucleotide sequence ID" value="XM_007875763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMA9"/>
    <dbReference type="STRING" id="1069680.M7NMA9"/>
    <dbReference type="GeneID" id="19895670"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01976"/>
    <dbReference type="eggNOG" id="KOG2788">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029942_1_0_1"/>
    <dbReference type="OMA" id="LPHFNAR"/>
    <dbReference type="OrthoDB" id="10262326at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003975">
        <property type="term" value="F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06855">
        <property type="entry name" value="GT_GPT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033895">
        <property type="entry name" value="GPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571:SF0">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMR09793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="443" mass="50568" checksum="A1A243A983D1E16F" modified="2013-05-29" version="1">MGWFLNSIFFLVSAIAIIINRYEHPLVISLAFSLVSGIFVFKAIPTLAPYFIKVGFYGKDLNKKGKPLKPEAMGIVCSMTYIFFMFLFIPFAFYKYFVMTSGGGNRDIYEVVKEEKTFQLFLHNKLGEYLSAILSLQSMVLLGAADDLFDIRWRDKLFMPVFSAIPILVVYYIDFDVTYVVVPTFLEPYLGNLIEIGWLYYLYMAALSIFCPNSINIIAGINGVEVGQSIIISLCIIINDLLYVFRLTGPSIDSHLFSLYFLLPFLGTSIPLLYYNWYPASVFVGDTYCCFSGMIFAIVGIIGHFSKTILLFFIPQIFNFILSFPQLFGIVECPRHRMPNLNLSTGLLEPSMVMFSKKPSFLCRIILKIFAKLGFVRLKIHPITKEIQGTTNLTIINFLLVRLGPKREDKLTIIIMEIQAVMGLIGLFIRHKMAKLIYLNDNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMD1</accession>
    <name>M7NMD1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">VPS37 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_03432</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875519.1">
        <property type="nucleotide sequence ID" value="XM_007877328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMD1"/>
    <dbReference type="STRING" id="1069680.M7NMD1"/>
    <dbReference type="GeneID" id="19897119"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03432"/>
    <dbReference type="eggNOG" id="ENOG502S268">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1454994_0_0_1"/>
    <dbReference type="OrthoDB" id="10260857at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678:SF2">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="6">
        <location>
            <begin position="33"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="186" mass="22243" checksum="EF39F1ADBD6E6322" modified="2013-05-29" version="1">MSRISIQENDSSIEIRENNNNIETLFIPSILYGKSQEDLEDVLNDSLLLDTILNITYPGILQQTNALIDAYKTNIQFSEELLNQKSYLLNLQKSTENIINQMKKYQRQWEDSKENMNISLQPFSKSYILFRLQNAIDEINNFSYSLQKLFIENKENTSLLIFIKEYRQARKLYYYRLEKKKIMEIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMF9</accession>
    <name>M7NMF9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2 10">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_03239</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2 10"/>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875305.1">
        <property type="nucleotide sequence ID" value="XM_007877114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMF9"/>
    <dbReference type="STRING" id="1069680.M7NMF9"/>
    <dbReference type="GeneID" id="19896926"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03239"/>
    <dbReference type="eggNOG" id="KOG0660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="OMA" id="IFDIQRP"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07849">
        <property type="entry name" value="STKc_ERK1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000040">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000073">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008352">
        <property type="entry name" value="MAPK_HOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01773">
        <property type="entry name" value="P38MAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="16"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR08402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="351" mass="40626" checksum="365924EEE42B330E" modified="2013-05-29" version="1">MTASVRNVRFNVSDDYEILDVVGEGAYGIVCSAVHKPSGQKVAIKKISPFDHSMFCLRTLREMKLLRYFNHENIISILDIQQPQDFESFSEVYLIQELMETDMHRVIRTQDLSDDHCQYFIYQILRALKAMHSANILHRDLKPSNLLLNANCDLKVCDFGLARSAVSTEDSSSFMTEYVATRWYRAPEIMLTFKEYTKAIDIWSVGCILAEMLSGRPLFPGKDYHHQLMLILDVLGTPTMEDYYGIKSRRAREYIRSLPFKKRVSFSSIFPRANPLALDLLEKLLAFNPAKRVTVEEALRHNYLEPYHDPDDEPTAPPISPNFFDFDRIKDSLTKNDLKILIYKEIMGMNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMK4</accession>
    <name>M7NMK4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="6">2.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_03191</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + acetyl-CoA = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="6">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.12" evidence="6"/>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875254.1">
        <property type="nucleotide sequence ID" value="XM_007877063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMK4"/>
    <dbReference type="STRING" id="1069680.M7NMK4"/>
    <dbReference type="GeneID" id="19896878"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03191"/>
    <dbReference type="eggNOG" id="KOG0557">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_10_2_1"/>
    <dbReference type="OMA" id="TMEFESF"/>
    <dbReference type="OrthoDB" id="537444at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000003">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006257">
        <property type="entry name" value="LAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01349">
        <property type="entry name" value="PDHac_trf_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 6" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="9" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="54"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="8">
        <location>
            <begin position="190"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="472" mass="52567" checksum="700B1B5F66A21049" modified="2013-05-29" version="1">MSLVRKAQIGLICLRFLNLKNPGNIRYWGIKPDSWLYKTSIFKRNYRGKALPTHRIINMPALSPTMSHGTIGEWKKKVGESISPGEILVDIETDKAQVDFEFQEEGYIAKILLESGTKDVEVGFPIAVLVEEESDVPAFSDFTIDDVKTKEKPVSKKSEVFKEEKLRSESLKKVEQVSSFTEEKSSDRIFASPIARLLATEKGIPLEKIKGTGPGGRIIKFDVDNFKLESVSSIQPAATHQALYTDIPLSNIRKTIASRLTESTQNTPHFYITISIVMDKVLKLREALNNNADGQYKISINDIIVKASAVALQKVPEVNSGWFGDFIRQYHSVDISIAVATPTGLITPIVKNVQNKGLLIINNEIKELGNKAREGKLKPEEYQGGTFTISNMGMYGIEQFTSIINPPQSSILAVGSIENFLVEDPGSEKQFKIEKRMKITLSSDHRVIDGAVAAKWVTMLKSILENPLDLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMW9</accession>
    <name>M7NMW9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor Iwr1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01782</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IWR1/SLC7A6OS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873750.1">
        <property type="nucleotide sequence ID" value="XM_007875559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMW9"/>
    <dbReference type="STRING" id="1069680.M7NMW9"/>
    <dbReference type="GeneID" id="19895476"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01782"/>
    <dbReference type="HOGENOM" id="CLU_1402970_0_0_1"/>
    <dbReference type="OrthoDB" id="6255506at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013883">
        <property type="entry name" value="TF_Iwr1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08574">
        <property type="entry name" value="Iwr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor Iwr1" evidence="3">
        <location>
            <begin position="115"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="194" mass="23202" checksum="43DCC6587D371FF2" modified="2013-05-29" version="1">MLQIKRKREEEAVPLIFVTKSSISKELTIPLKRRKQGNNCNKIIIRCAYINKNQVFILFKTLEAESITKFEQEHEKRTIETSNEQDEESRQNEMRILNIEKSHEYTESIFEPFAKDYVYDMYMPLVYTPDTLQTNPICFGILTLEEDNDISFLEETDSYDKYNDDEDSNEEDFYQNSYPDEDEWPNSDVEEREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN26</accession>
    <name>M7NN26_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873810.1">
        <property type="nucleotide sequence ID" value="XM_007875619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN26"/>
    <dbReference type="GeneID" id="19895531"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01837"/>
    <dbReference type="HOGENOM" id="CLU_2237738_0_0_1"/>
    <dbReference type="OrthoDB" id="5382624at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="105" mass="12097" checksum="5C414AC8CF129E61" modified="2013-05-29" version="1">MASLFSIPPNRKALSMLLVGVGSAAAVYYYMYHYNNVKVPQGKFEQLEKKAGDAYDNITSHVKDAYRTGKKQINNAEKKYEKKVHNLVDQVNIKMDKIKEYIEHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN76</accession>
    <name>M7NN76_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">26S protease regulatory subunit 10B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_02860</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874897.1">
        <property type="nucleotide sequence ID" value="XM_007876706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN76"/>
    <dbReference type="STRING" id="1069680.M7NN76"/>
    <dbReference type="GeneID" id="19896547"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02860"/>
    <dbReference type="eggNOG" id="KOG0651">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_2_2_1"/>
    <dbReference type="OMA" id="DHEPCVI"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045899">
        <property type="term" value="P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000008">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000034">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="65"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR08682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="288" mass="32696" checksum="99E86A1353699BCB" modified="2013-05-29" version="1">MTTLTIMRILPREVDPLVYNMSLEDPGKMNFTNIGGLDEQIRKLREVIELPLKNPELFRRVGIKPPKGVLLYGPPGTGKTLLARAVASSLETNFLKVVSSAIVDKYIGESSRLIREMFGYAKEHEPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNCMDGFDYLGQTKIIMATNRPDTLDPALLRPGRLDRKIEIPLPNEQGRLEILKIHAQDIQKQGEIDYEAIVKLSDSFNGADLRNVITEAGFFAIRDDRDYIIQNDLMKAVRKVAEAKRLEDKLEYKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN99</accession>
    <name>M7NN99_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome assembly chaperone 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_03072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875128.1">
        <property type="nucleotide sequence ID" value="XM_007876937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN99"/>
    <dbReference type="STRING" id="1069680.M7NN99"/>
    <dbReference type="GeneID" id="19896759"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03072"/>
    <dbReference type="HOGENOM" id="CLU_1807019_0_0_1"/>
    <dbReference type="OrthoDB" id="5593278at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053720">
        <property type="entry name" value="Psm_Assembly_Chaperone"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="16470" checksum="4C76BA7F0D9BC952" modified="2013-05-29" version="1">MNPYFTPKKITRTITPYRPLQLYIQGFLDCIFIIATMRGNVSEWISIDLNQAIPLFDQTSIAQQDQLPLSHLSAKFLLGASHLPRADFARMLACQIASYIVRDSVKEQRMVLVGFGLDWTEDLEGQRSLYNNVLKMLEECKVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNS1</accession>
    <name>M7NNS1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">rRNA-processing protein EBP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01589</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873543.1">
        <property type="nucleotide sequence ID" value="XM_007875352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNS1"/>
    <dbReference type="STRING" id="1069680.M7NNS1"/>
    <dbReference type="GeneID" id="19895284"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01589"/>
    <dbReference type="eggNOG" id="KOG3080">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036007_2_0_1"/>
    <dbReference type="OMA" id="KIENIHD"/>
    <dbReference type="OrthoDB" id="443772at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000280">
        <property type="term" value="P:nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008610">
        <property type="entry name" value="Ebp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028">
        <property type="entry name" value="RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028:SF0">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EBP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05890">
        <property type="entry name" value="Ebp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="248"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="172"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="37695" checksum="C8D1868876A65699" modified="2013-05-29" version="1">MDFSKKKDLKAPFKAKKDLNDGELDHLKTEFIEGEELNNSSEKVNNKEIFEEKKESDDESLEEEILLSEVESFSDFDVPIYQKLTINNKEALNRIFESIIIPETKFDENQVITSKESIKIENIHDDFARELAFYKQGLEAAIRGRQAILDKNGIFSRPYDYFAEMLKSDEHMQKIKDKLIKEETEKKAIESARRQRELKKIGKKVQIEKIHQRHQEKKEILDKIKNLKKKRKYDQELTTDDNFDVELEKASSVSKRQKTSKRQKKDKNYGFDGKKKYKKSNDTKSTDSMFEFSVKKMKQPFKNYSNIQKKTRRKSHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNW3</accession>
    <name>M7NNW3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major surface glycoprotein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01641</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10388.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873597.2">
        <property type="nucleotide sequence ID" value="XM_007875406.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNW3"/>
    <dbReference type="STRING" id="1069680.M7NNW3"/>
    <dbReference type="GeneID" id="19895335"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01641"/>
    <dbReference type="eggNOG" id="KOG3544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010455_0_0_1"/>
    <dbReference type="OrthoDB" id="5400168at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021041">
        <property type="entry name" value="Maj_surf_glycoprot_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003330">
        <property type="entry name" value="MSG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02349">
        <property type="entry name" value="MSG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12373">
        <property type="entry name" value="Msg2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006963414" description="Major surface glycoprotein 2 C-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="domain" description="Major surface glycoprotein 2 C-terminal" evidence="4">
        <location>
            <begin position="859"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="817"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1022"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="579"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="765"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="834"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="845"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1030"/>
            <end position="1049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR10388.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1073" mass="122376" checksum="4250A335BE812041" modified="2016-03-16" version="2">MINKIILIAILNLIALTYGNQNVDLSIRSSQKNAVNPLFKDFIVKEDIYAFILKEDYNDENKCKAKLEEYCKELKDIDPELNKVDTNIKEICNNNNKGQKCKDLKPNIEKNLNQVSNDLSTKIPGSIDYMDVDKAFLKCLFLHDLTRNILAYCNLLEYYYQKREHLRLMYGVILRAVGDSIANYDDFKEKMKEICPILVQQGINFISECFEIEESFRELNKYINYSCNSLNVNLNDNKLQEQCYEKLKSCYFLKNKCEKKCDELKVLCEKKNITYKLPRKDYNPIKPETTLLKIELEDFYKKIKDKKIYIENLETTSDDIILYLSNAYTGFSENICKNKLNKNCDFFKFLSPEFKELCQDNIKKRCKDASKIIDRCRKLKMTLYLAGFSSHFEDNVIGKEISRDRLSTSFNSREFSNFNTNCFFIRKSCVNNFFEGCRAAYYANNKKLQERSFIKLIESKLIEEQYNLKSKDEKLKICQKTIIEKCVALANSDIRNFLICLRPKEICLRLEEIIFTLSKDLEQALDQARDFPKEEDCVELKKECEGILKDLGSNNVKCVTLKKRCKYLEVTKELKYDFLKDKSDSLANIQNCMKALKEKCDRLFKRGTNAFGVSCALPEETCKFMVSEVENHCNAFKNNIEKHDVVNKSKNGNETLVEEICTLWDPYCDELMENCPDKLKKGDNGNEKGVCLQLKENCRPFFEKLKLEDELTHELKGSLSNETECKKALGKHCSEQKNSGNQKFNSFCNTDKDKDVEEKVCKKLVEKVKEKCPTLESELSKEKDELKKKKDEYEKVKQESEKFSEEVKLLLSRLGKDGQDAGSKVQNTSAAEPAAPPGGAPAPAVPGGSTPSGGANTNNVILVRRTFVSGEVSEAEKKAFVATARALELYLELKEKCKGLQGDCGFRKDCPKCDAACTEIDKLCEGIEGLKVTPYYTVTSTATQTTTTTATTTTITTTTTTTTTTTTATTTESVDGGKVTDECTLVQTTDTWVTSTSLHTSTMTSTSTLTSTVTLTSMRKCKPTRCTSDSNKETEAQKEEEKEEEVKPNEGMKMRVPEIVKIILLGVMVIGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNZ2</accession>
    <name>M7NNZ2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major surface glycoprotein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02988</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875036.1">
        <property type="nucleotide sequence ID" value="XM_007876845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNZ2"/>
    <dbReference type="STRING" id="1069680.M7NNZ2"/>
    <dbReference type="GeneID" id="19896675"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02988"/>
    <dbReference type="eggNOG" id="KOG3544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010455_0_0_1"/>
    <dbReference type="OrthoDB" id="5400168at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021041">
        <property type="entry name" value="Maj_surf_glycoprot_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003330">
        <property type="entry name" value="MSG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02349">
        <property type="entry name" value="MSG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12373">
        <property type="entry name" value="Msg2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082173" description="Major surface glycoprotein 2 C-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="domain" description="Major surface glycoprotein 2 C-terminal" evidence="4">
        <location>
            <begin position="879"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="821"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1056"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="766"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="834"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="864"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1063"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1106" mass="126070" checksum="ADE5AE624F3A02CA" modified="2013-05-29" version="1">MINKIILIAILNLIALTYGNQNVDLSIRSSQTNAVDPSFENFIDRENIYAFILKKDYDDENKCKAKFEEYCEELKNIDPELNKVDNTVKEICNNNNKEKQCKLIKKIIQGKLKKMAKEIKDFLHYGGLAQKCIEYIEECSFFQDVDLGEIKKNCILLRNECSKKKNTIISQEVILRTLKVSSISLSECKSNIYNFCSLLAWESDTLMELCIDQSNSCLVLGSATFNFCLSISRSFDNNKECHEQLENCYFYMPFCQNAKEKCDEWEKECLKKNITYKSLDLDLNPLKPPKTLLQKIKLEDIYKKEADKGSIIGKPEKIGFRDFILFLSRLEGMHNIEEACENAVKKYCRNTKYLSYEINSFCNDQDKEKKCAELTNVKARCINFKLKSYLKGLSTEISTKESRALDWDKLPKSLTRKECIYFSTECLRLSGICKNGINQVCDHINEVCYRKAENAALNKIFMPALRGILYNFESNATMLSCQEKVLDICTTFKNSNKRYFAKCLRPKEQCLELKNYISSQSEELEQVLDNVRDLPKESDCIELQEKCHDLRGYSNFIDNKCVILNRRCRYLEITKELKKRLLKRGDDVLKTQGNCTAGLKKECKELSRRGKEEFSVSCALREETCSFMVKQTENECIFLKNNMESEKIIDKIENGKTNETLVEEICMLWYPYCHQYMENCPDRLKKGDNGSGKGICLQLEEKCKPFFEKLKLEDELMHKLKGSLGDETKCKETLGKHCTEWKKEGNQTLNSLCEDTKKEELCKKFVGKIKEKCQTLENELNKEKDELKKKKDEYEKVKQEAEEFAKKAKLLLLRLGKDVQGAESKVQDNSSPKSVPPSALPPAQPQPPTGSSRLPSGGIPAGLPTPGGSTPSGTTNTNNVILVRRTFVSGEVSETEKKAFVATARALELYLELKEKCKSLKGDCEFRKDCPGCDAVCTEIDKLCEEIKPLKVTPHHTMTLMTTEITTTTMITTTTTMITTTTTTTTTTTTTATKSIHGEKVTEQCAFSQTDIWMTNTSLHTSTMTSTSTVTSTVTSTVTSTVTSTVTLTSMRKCKPMRCTSDSSKETETQKEEEKEEEVKPNEGMKMRVPEIVKIILLGVMVIGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPE0</accession>
    <name>M7NPE0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873207.1">
        <property type="nucleotide sequence ID" value="XM_007875016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPE0"/>
    <dbReference type="STRING" id="1069680.M7NPE0"/>
    <dbReference type="GeneID" id="19894980"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01283"/>
    <dbReference type="eggNOG" id="ENOG502QQ2V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059017_0_0_1"/>
    <dbReference type="OMA" id="NIMFATR"/>
    <dbReference type="OrthoDB" id="5549748at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018859">
        <property type="entry name" value="BAR_dom-cont"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10455">
        <property type="entry name" value="BAR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="1">
        <location>
            <begin position="15"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="285" mass="32203" checksum="5502BFF0E595B4D3" modified="2013-05-29" version="1">MDAFKSLHSISLNKPFSSISPFAKRTAQLVRQTIGTADNLTELPEEYLELERYVDQLKVVYTKLLSVTSTYDNESYDYPANLRETFSEFSKSIQEKVQNLATAHSATEVQAAFLKPTSKGVSKTLPHALSRAAMSCSEQLDDSNPLKDVLMIYADAQDKIGNSRLKQDSRISESFNGYLTSNLATVFSCAAKARKNVNIRRIDLDSFKSSAKTVKPEKHEQLCRDIEHAEDVFVTAVEEAIQIMKNALEIPELILQFREFVDAQLCFHKEAYEILLNLSERLSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPF4</accession>
    <name>M7NPF4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Pre-mRNA-splicing factor cef1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02751</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CEF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874782.1">
        <property type="nucleotide sequence ID" value="XM_007876591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPF4"/>
    <dbReference type="STRING" id="1069680.M7NPF4"/>
    <dbReference type="GeneID" id="19896442"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02751"/>
    <dbReference type="eggNOG" id="KOG0050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009082_0_0_1"/>
    <dbReference type="OMA" id="KMGMAGE"/>
    <dbReference type="OrthoDB" id="1410009at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140602">
        <property type="term" value="C:nucleolar peripheral inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11659">
        <property type="entry name" value="SANT_CDC5_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000021">
        <property type="entry name" value="CDC5 cell division cycle 5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047242">
        <property type="entry name" value="CDC5L/Cef1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021786">
        <property type="entry name" value="Cdc5p/Cef1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047240">
        <property type="entry name" value="SANT_CDC5L_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885:SF1">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11831">
        <property type="entry name" value="Myb_Cef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="10">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="9">
        <location>
            <begin position="2"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="9">
        <location>
            <begin position="54"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="10">
        <location>
            <begin position="58"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="110"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="248"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="431"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR08976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="759" mass="87753" checksum="1F70009D6BF75EB8" modified="2013-05-29" version="1">MAPAVKGGIWKNIEDEILKAAVSKYGKNQWARISSLLVRKTAKQCKARWYEWLDPGIKKIEWNKEEDEKLLHLAKLMPTQWRTIATIVGRTATQCLERYQRLLDDAEANDSTMNLGGPGCETSAPTADDVRRLRPGEIDPNPENKPALPDAVDMDEDEKEMLSEARARLANTQGKKAKRKAREKQLEESRRLAVLQKRRELKAAGINIKLHHRKKGQMDYNADIPFEKKPALGFYDTTEEQLMNEAIKNNADLSQFDRKKKDQEDTDKKKRKKEEFSKSVTAAFQASENARNIQKLKDAEQLSKRRKLILPEPQINDNEIDEVIKLSKSGDYARSLVSMTENEATKGLIGQYSQINTSISIRTPRTPLQEDRLLIEAKNLRALTQQQSSLFGDENTPLHQPVETDFNKGALRNTPVTPNPLAMSFHQRNASIKPNSTPFRTPRDNFNINQRDPNSAEFTDKEELYGKSQKEYLRSKFSSLPKPLNDFELELPIEEDYNDKPKQSVIEEDAQEKEKKNQTLDEKQNFLDLKSKVIQKGLPRPPIIDMRLLLEWLEPAQGAELLITKEMIKLLSYDTSRYPILEDKIIGTSHFIDNISNDLMHHANNEIQKEIDKYNSITIDPYMRLINERKNLYNFISDPEKSSKNSLDDLKNYWKIIQENISKEANNGNKIEKRLDVLLSGYQIRSKIISKKIYNSIEAISLAKQELYCFQNLNLSEKIVLPKRLNSLKNDVQFLKERESREQTKYQYLLEKKKNLPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPJ2</accession>
    <name>M7NPJ2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01330</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873257.1">
        <property type="nucleotide sequence ID" value="XM_007875066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPJ2"/>
    <dbReference type="STRING" id="1069680.M7NPJ2"/>
    <dbReference type="GeneID" id="19895027"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01330"/>
    <dbReference type="eggNOG" id="KOG1639">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059260_0_0_1"/>
    <dbReference type="OMA" id="ATMPIFN"/>
    <dbReference type="OrthoDB" id="540503at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF28">
        <property type="entry name" value="VERY-LONG-CHAIN ENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="149"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR10628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="297" mass="35316" checksum="FDA96613735F3EAA" modified="2013-05-29" version="1">MKEFALKSKGKHIKGLKEKILVDLDDKKIGIIFKEVSNTTGLSESRLRLLVKDRILKKEDNIEEILDENCIYVKDLGPQIGWKTVFLVEYLGPLWIHPLIYGSSLFQRLLYGKAVEHSYNQRIVFILVILHFIKRELETLLVHRFSISTMPRRNLFKNCFHYWVLGGINMAYWVYGPWFSYLYQSPIILISFVILWMLSEYANLKTHLILRNLRPEKTSIRQIPKGFGFDLVSCPNYFFEYISWFVIACLSHSLSSWLFLAVSGIQMWLWALKKHTRYIREFSDYPKRRKIMFPYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPW0</accession>
    <name>M7NPW0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein translocase SEC61 complex gamma subunit, archaeal and eukaryotic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_00892</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872803.1">
        <property type="nucleotide sequence ID" value="XM_007874612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPW0"/>
    <dbReference type="STRING" id="1069680.M7NPW0"/>
    <dbReference type="GeneID" id="19894590"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00892"/>
    <dbReference type="eggNOG" id="KOG3498">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_167752_2_0_1"/>
    <dbReference type="OMA" id="KPDQKEY"/>
    <dbReference type="OrthoDB" id="2401875at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071261">
        <property type="term" value="C:Ssh1 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008158">
        <property type="entry name" value="Translocase_Sec61-g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00327">
        <property type="entry name" value="secE_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12309">
        <property type="entry name" value="SEC61 GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR10743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="69" mass="8017" checksum="0D3970EC66C6708F" modified="2013-05-29" version="1">MSTQIKEWLDLLNDFLKEGTQFINRCTKPDKEEFFRISWAIGIGFLIMGFIGFFVKLIHIPINNALLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPZ0</accession>
    <name>M7NPZ0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874531.1">
        <property type="nucleotide sequence ID" value="XM_007876340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPZ0"/>
    <dbReference type="GeneID" id="19896213"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02521"/>
    <dbReference type="HOGENOM" id="CLU_2146930_0_0_1"/>
    <dbReference type="OrthoDB" id="5409734at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="112" mass="13358" checksum="8F6E25E6A57540C0" modified="2013-05-29" version="1">MTNSKLYKKTTEENETPFFYSFLFTIFLTIIAAIILILSYKKAIKLVPNRKRYIHIFNPISDFNRMKIPLQLFPDNKIRIRLSDEEAINYAFDDSDNENSILIYKKEKMQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ53</accession>
    <name>M7NQ53_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PNEG_02338</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874342.1">
        <property type="nucleotide sequence ID" value="XM_007876151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ53"/>
    <dbReference type="STRING" id="1069680.M7NQ53"/>
    <dbReference type="GeneID" id="19896031"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02338"/>
    <dbReference type="eggNOG" id="KOG0419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_10_2_1"/>
    <dbReference type="OMA" id="DHKSQYI"/>
    <dbReference type="OrthoDB" id="9984419at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033503">
        <property type="term" value="C:HULC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990304">
        <property type="term" value="C:MUB1-RAD6-UBR2 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097505">
        <property type="term" value="C:Rad6-Rad18 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990305">
        <property type="term" value="C:RAD6-UBR2 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990303">
        <property type="term" value="C:UBR1-RAD6 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034620">
        <property type="term" value="P:cellular response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071629">
        <property type="term" value="P:cytoplasm protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007535">
        <property type="term" value="P:donor selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042275">
        <property type="term" value="P:error-free postreplication DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031571">
        <property type="term" value="P:mitotic G1 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000639">
        <property type="term" value="P:negative regulation of SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090089">
        <property type="term" value="P:regulation of dipeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009302">
        <property type="term" value="P:sno(s)RNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120174">
        <property type="term" value="P:stress-induced homeostatically regulated protein degradation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23790">
        <property type="entry name" value="UBCc_UBE2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000007">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0749">Sporulation</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 19" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="21">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="18">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EMR09392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="150" mass="17275" checksum="59B9F5A8DA1F5142" modified="2013-05-29" version="1">MSSPARRRLMRDFKRMQQDPPAGVSASPIADNVMLWNAVIIGPAETPFEDGTFRLIMQFDEQYPNKPPFVRFLSKMFHPNVYTNGELCLDILQNRWSPTYDVAAILTSIQSLLNDPNNNSPANAEAAQLNKDNKKEYIRRVKETVEWSWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ65</accession>
    <name>M7NQ65_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">RuvB-like helicase</fullName>
            <ecNumber evidence="15">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PNEG_02575</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="15"/>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874590.1">
        <property type="nucleotide sequence ID" value="XM_007876399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ65"/>
    <dbReference type="STRING" id="1069680.M7NQ65"/>
    <dbReference type="GeneID" id="19896267"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02575"/>
    <dbReference type="eggNOG" id="KOG2680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028311_4_0_1"/>
    <dbReference type="OMA" id="IINTEPY"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097255">
        <property type="term" value="C:R2TP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002221">
        <property type="entry name" value="RuvB-like 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000002">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 15" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="59"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMR09241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="458" mass="51259" checksum="C7D671A9A15F817C" modified="2013-05-29" version="1">MEKILSQRLERLGEHSHIRGIGLNDRLEPRPSAEGMVGQYQARKAAGVLLQMIKEAKITGRAILISGPPSTGKTAIAMGMAQSLGSEVPFTMISASEIFSLEMSKTEALIQAIRRSIGVKIKEESEIIEGEVVEIQIDRSITGGNKRGKMIMKTTDMETVYDLGNKMIDALTKEKVIAGDVILIDKASGKISKLGCSFARARDYDAMGSDTKFVQCPEGELQKRREVTHTVSLHEIDVINSRTQGFLALFSGDTGEIPSEVRDQINTKVNEWKEEGKAEICSGVLFIDEVHMLDIECFSFLNRALEDDLSPIVIMASNRGIARIRGTKYKSPHGIPLDFLDRMLIISTSQYSVDEIKQILHIRCQEEDVEISPNALSLLTKIGQETSIRYSIHLIATAYLIAQKRKSTQIDIEDIQKSYTLFLDQARSVQYLEEYAQQYISENDYIDKIDDIKPMEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQG2</accession>
    <name>M7NQG2_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin-like protein pmt3/smt3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874075.1">
        <property type="nucleotide sequence ID" value="XM_007875884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQG2"/>
    <dbReference type="STRING" id="1069680.M7NQG2"/>
    <dbReference type="GeneID" id="19895789"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02095"/>
    <dbReference type="eggNOG" id="KOG1769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148322_4_2_1"/>
    <dbReference type="OMA" id="MKIYCAR"/>
    <dbReference type="OrthoDB" id="442921at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16116">
        <property type="entry name" value="Ubl_Smt3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000208">
        <property type="entry name" value="Small ubiquitin-related modifier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10562">
        <property type="entry name" value="SMALL UBIQUITIN-RELATED MODIFIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="13"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="107" mass="12541" checksum="DBCD487BF0F7617C" modified="2013-05-29" version="1">MSASAEEDKKPSEHINIRVVGYDSNEVFFKIKRHTPLKKLMEAYCERQGKSMNMLRFLVDGERARPEQTPAQLDMEDGDQIEVMIEQLGGYQSNIKCYRVRVDVRMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NR78</accession>
    <name>M7NR78_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02205</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874188.1">
        <property type="nucleotide sequence ID" value="XM_007875997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NR78"/>
    <dbReference type="STRING" id="1069680.M7NR78"/>
    <dbReference type="GeneID" id="19895898"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02205"/>
    <dbReference type="eggNOG" id="KOG1647">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069688_0_1_1"/>
    <dbReference type="OMA" id="REEFFRM"/>
    <dbReference type="OrthoDB" id="7676488at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR09621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="28220" checksum="5130200CFE88AA8C" modified="2013-05-29" version="1">MGDQSHRENVFPTRQSLGIMKTKLKGAITGHSLLKRKSEALSKRFRTVIGLINDVKREMVQAMQLAAFSLAEMNYVMGDDVKYQIFENTQTSCCRLKTKYENISGVFLPIYECSMRNINDHRFIGLGKGGQKVQKCQEMYTKAIDVLVRLASLQTAFIILDDVIKITNRRVNAIEYVIIPKVENTIKYINSELEELEREDFTRLKKVQVKKKVDIEKENKEKEQMKKVIMVNVLESNEDTDIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRA6</accession>
    <name>M7NRA6_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prefoldin, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UXT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874223.1">
        <property type="nucleotide sequence ID" value="XM_007876032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRA6"/>
    <dbReference type="STRING" id="1069680.M7NRA6"/>
    <dbReference type="GeneID" id="19895932"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02239"/>
    <dbReference type="eggNOG" id="KOG3047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121199_1_0_1"/>
    <dbReference type="OMA" id="HMPDGYK"/>
    <dbReference type="OrthoDB" id="433124at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23158">
        <property type="entry name" value="Prefoldin_UXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003994">
        <property type="entry name" value="UXT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13345">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13345:SF9">
        <property type="entry name" value="PROTEIN UXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01502">
        <property type="entry name" value="UXTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="145" mass="16871" checksum="608B374ED05993BF" modified="2013-05-29" version="1">MIIDHNLNSSSINLKKYISFMNNVLQPKLYSLIKEREELDKSLSEYFKLKSHILQIQNEKLSQMKVMVDIGSNFYVQTKIENTSKIIVSLDCKGIYIEMTQEEALEFIDKKENIIRKKAEAKSTHINQIRAYIIIILEAISKISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRK3</accession>
    <name>M7NRK3_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein BMH1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01662</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the 14-3-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873623.1">
        <property type="nucleotide sequence ID" value="XM_007875432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRK3"/>
    <dbReference type="STRING" id="1069680.M7NRK3"/>
    <dbReference type="GeneID" id="19895356"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01662"/>
    <dbReference type="eggNOG" id="KOG0841">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058290_0_0_1"/>
    <dbReference type="OMA" id="KGCQLAR"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11309">
        <property type="entry name" value="14-3-3_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000002">
        <property type="entry name" value="14-3-3 protein epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00797">
        <property type="entry name" value="1433_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="7">
        <location>
            <begin position="4"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="233"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="4">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="4">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="268" mass="30049" checksum="E6CD9564BD20ACFB" modified="2013-05-29" version="1">MTTREDSVYLAKLAEQAERYEEMVESMKRVASSDQELTVEERNLLSVAYKNVIGARRASWRIVSSIEQKEENKGNFSQAGLIKDYRSKIESELTSICNDILAVLDTHLIASANTGESKVFYYKMKGDYYRYLAEFAVGDKRKTPSDASLAAYKEASDIAGTDLPPTHPIRLGLALNFSVFYYEILNSPDCACHLAKQAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQDSNEKNDSKEAVSEIPDPGKPSETEASKTDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRP4</accession>
    <name>M7NRP4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00441</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872319.1">
        <property type="nucleotide sequence ID" value="XM_007874128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRP4"/>
    <dbReference type="STRING" id="1069680.M7NRP4"/>
    <dbReference type="GeneID" id="19894139"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00441"/>
    <dbReference type="eggNOG" id="ENOG502QRKD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028484_1_0_1"/>
    <dbReference type="OMA" id="LPFAPNM"/>
    <dbReference type="OrthoDB" id="17415at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF5">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR11418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="493" mass="58435" checksum="6B99AA1F274D0AFE" modified="2013-05-29" version="1">MSISTFYRNRPFSYNLSRLYCQTIYYPKRYNTSWQIWKNTEIQTPTYPYRAGNVSYNFSSEDLPQKCQTVNAMLLLTEKTPPRQVQMLVRDFIEDSIYNPFYGYYNKHSCILSIPTSFEFSKIKDNNSFQKELGKIYENYDKMAVQKGAKLPIQLWHTPTELFKPYYGEAIARYILTHYKLSYYPYDDLIIYEVGSGNGTLMLNVMDYIDRMDPDVYARTKYYAIEISHPLATQQIEMLKNTKHYCEHQEKVEIINKSIFDWNTLNSNPCFFILLEVLDNFPHDLIRYNPITQQAYQALAVIDEIGDIHEFYSPILDPLIIRYLSLKKKITQTYKSKYNDISYLIKRLKTYLPFSENLIDPEFIPTKQLLLFDILRNYFPEHKLIISDFFSLPDTIQGLNAPIVQTRFSGMTIPCSTYLVKQGYFDIMFPTNFEVLKNVYKATCLQPGENRHIEIYTHRRFLEQWADIETTKTISGENPMLDWFENVKILITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSN7</accession>
    <name>M7NSN7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_01417</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873355.1">
        <property type="nucleotide sequence ID" value="XM_007875164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSN7"/>
    <dbReference type="STRING" id="1069680.M7NSN7"/>
    <dbReference type="GeneID" id="19895114"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01417"/>
    <dbReference type="eggNOG" id="KOG2042">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SNAFMTN"/>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071361">
        <property type="term" value="P:cellular response to ethanol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16657">
        <property type="entry name" value="RING-Ubox_UBE4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="12">
        <location>
            <begin position="905"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="974"/>
            <end position="993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR10141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="993" mass="115448" checksum="38CE3BF4CEA8E658" modified="2013-05-29" version="1">MELKERDRKIEEELDINNRENPVSSSDKIPIKTVYISEFVAWESSTLSKILQVTLDLEGHLKVPNYMFLSNLRQELIDESLEPVISIDTLDRVILARLSMPSPNQPFDYLVSCWKRAISVQKLIQKLPDVEEKLKIIKKAKRLFVSYSGLSITLPEMFELQHAPIDFANKLLQELDTSNGIPFDFLRELVHQFDKEGTLTDLLGETIVELSRRLCQKTIMDDYQPYIKVFNQLVTLKPFTLMVIRLPAWLPENSTAADIEYTSILGPYLRLTPMQAKISELYFSNASQRSQADILGSINSLRLTMRTLQNQLFFIINTIVRTSPECKEKMLEYFAKVLELNKKRKALHADPKSISTDGYIVNITNIINSFSEPFIDVNYLKIDRIDIDYFKKRPRISIAKETKLNSDEKTSELFYEDEIQDIPNFISEIFFLNVAYHYYGLGSAMLNHEHIMKRISDLQKQYDILESQKSHWIKTTHASILNTNMKQLHLQIEKTKSYCYCFDTMLLDNVLQSKSFSFLSLLASWLLRHVDPEHQHPQKIITLPLPQNVNDNIRNLPEYFVEEIADFFLYMSKYNPELIISNSAIELVIFIITFLKSPSYIKNPYLKAKLAEILFYGILKQHNYPYGVLGDILNSNTFSLHHLLPALMLFYVEVESTGLSSQFYDKFNIRYQISQIFKAIWENPGHREKLLLESRNNFNFFVKFVALLLNDVTYLLDEALSKLLEIHNLQLELENVPENLSLNDERQEKRHYLAQLEKYATTYMSLATETIELLKRFTASIPDAFCCPEVVDRLAAMLDYNMNALVGPKCTKLKVRNPEKYRFEPKSLLSTIADIYLNLRSKKSFIMAIAKDGRSYKRDLFIRATQIFKKYSTKSLDDINNLLSLINDVEEVKKKDEDNEEELGEIPEEFLDPIMACLMTNPVILPSSRVTVDMATIKSHLLSEEKDPFNRSPLKLEDLIPNEELKAKVEMFKAERRANKTKKEDKNDNQLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSP2</accession>
    <name>M7NSP2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MHYT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873360.1">
        <property type="nucleotide sequence ID" value="XM_007875169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSP2"/>
    <dbReference type="STRING" id="1069680.M7NSP2"/>
    <dbReference type="GeneID" id="19895118"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01421"/>
    <dbReference type="eggNOG" id="ENOG502QTP5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008375_2_0_1"/>
    <dbReference type="OMA" id="HQEFGHI"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005330">
        <property type="entry name" value="MHYT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152:SF1">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03707">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50924">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="MHYT" evidence="2">
        <location>
            <begin position="15"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="731" mass="83125" checksum="B58D83130A8AE578" modified="2013-05-29" version="1">MSQELVYGEKTEQHISPKIVLVSYFISVLGSYTTLELLRHRTSVHGIFNWSLLLSSSLSMGGIAIWSMHFLGNRAIILHDGDPQYQLEYNAGFTALSFFLPVLVLLLAYLLTGTNEKVSPIRILGGGIIGGLAICGMHYTGQAGISNYIAFYNIGYVIGSVIIAICATVFTLALFFTLQSKWTNAWWKLLGCSFLLASAVSGMHWIASLGTVYRYRRITNKGISQKTTIIFIGVISATACFLLLALSFEATRRLKARKDRAQKVVLTRAIFDSEGKLLVTIDGMLISHEITDTYHKRSLNDEFDVDHHVFYWIYKVSRAWKSVINLVPIMKDHVKLSDPSDNQQIDYSLIFKERFIVTATRLAELLHEPLHQVGILYDGIMKTGQKKIQQSKHDKEILNPISRMYGKGQMLFLIKHANRSECNRYLSYGFRFAPVHLILDGLVRSLQVPRAEITEYIDSMRLYRIYEDSYKPGIYVGIFIIKAHVHHGLKILVDKFNDCMIPCKMLSLRMLDQEQMSFLKSSENVTAKQVLHFLTQNDHPQTFGSSMTLFKAELKEALLQISRYVNEYLFQDAILIPELIRIPCSGHYQGKHATIILFRHIIPIHVHLQPNNNVKFIPLSLFKANQWSILGQGEALFTQDIRRDFSPILKDLERIRTSQSSYPIITTIQKSEENFNPTFNGITISKSVSVSIEDQFNTHSHGNITNQTAVETTSCDVLWVDEVLSGIVWNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSV5</accession>
    <name>M7NSV5_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonucleoside-diphosphate reductase small chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873567.1">
        <property type="nucleotide sequence ID" value="XM_007875376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSV5"/>
    <dbReference type="STRING" id="1069680.M7NSV5"/>
    <dbReference type="GeneID" id="19895305"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01610"/>
    <dbReference type="eggNOG" id="KOG1567">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035339_2_1_1"/>
    <dbReference type="OMA" id="SNPFPWM"/>
    <dbReference type="OrthoDB" id="10248373at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="394" mass="45538" checksum="5944CF0CF5B17549" modified="2013-05-29" version="1">MEHELTPSKKVAEGILELNLTKEELEAAKNAKETLIKLKIKARKNKSDINGSDLEENALNIMEEEPLLMENKKRFVLFPIKYHEIWQMYKKAEASFWTTEEIDLSKDLHDWDKKLNDDERFFISHVLAFFAASDGIVNENLLERFSNEVQVPEARCFYGFQIMMENIHSETYSLLIETYIRDPGQKKFLFDAIETIPSIKLKADWALRWIADEHSTFAERLVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHTDFACLLFSHLRKRPSKETIQAIIVEAVSIEQDFLTSSLPCPLLGINARLMKQYIEFVADRLLVALGNNKYYNVTNPFDFMENISLQGKTNFFEKRVSDYQKSGVMASIKKQSDFELIDGHVFSVDEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTE9</accession>
    <name>M7NTE9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 5B</fullName>
            <ecNumber evidence="3">3.6.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Translation initiation factor IF-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PNEG_01263</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873186.1">
        <property type="nucleotide sequence ID" value="XM_007874995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTE9"/>
    <dbReference type="STRING" id="1069680.M7NTE9"/>
    <dbReference type="GeneID" id="19894960"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01263"/>
    <dbReference type="eggNOG" id="KOG1144">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002656_1_0_1"/>
    <dbReference type="OMA" id="EYSFPQD"/>
    <dbReference type="OrthoDB" id="4928at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03703">
        <property type="entry name" value="aeIF5B_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000013">
        <property type="entry name" value="eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000112">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029459">
        <property type="entry name" value="EFTU-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003078">
        <property type="entry name" value="PRK04004.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14578">
        <property type="entry name" value="GTP_EFTU_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 16" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="15">
        <location>
            <begin position="462"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="65"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="119"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="180"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMR10557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1058" mass="119382" checksum="7857EE2B2FA7C25D" modified="2013-05-29" version="1">MGKANKKKLNDDIWDKLGEDIVPQNINENIHSEPLKNDAVKFDSKLDDLVEDFGGLLSTLKASSKNRSLKKDKKSLIQNSERSNNNLLKDSSIKEGFNQDHELVKQNDEQVYEIRLKTKSEKEKEKKEKEKAKKKAQSEKKKSINKLTLKNETETTKTGDQINEPIIIENGLQDSKNSIKKNKEIKAKKINVNIAAIQKQVELRLQAEEERRKQEEEERRIIEEEERKIQEEERRKCEAKLKKKEREKAKKEELKSQGKFLTKKQKEQKQMAQIKIQQLLATGVRIEGLVTNNKINSDSSEKLKRSVCDSKKKKLHITSEITDSNSSELATALDHSFKNDDNVEIPIQKINGETLEVDSEDGILDNWEEAFIDNFDNDDTNFLLKTSNTVDSKILDGDSFHESLKAQVNNCIKKVDGMNNSQVNDTVVKKEEVISQSSDVKTNQNSMFKKSSKNAKNIESDLRSPICCVLGHVDTGKTKILDKIRQTNVQEGEVGGITQQIGATYFPVDSIKQKIAVLDQNEKLEYKVPGLLIIDTPGHESFANLRSRGSSLCDIAILVVDIMHGLEPQTLESLSLLRSRKTPFIVALNKIDRIYGWNPTLDGAFQESLLKQKKSVQREYHDRYTKIIVAFLEQGLNAVAYYENKNFSKNVSIVPTSALTGEGIPDMLMLLLNLTQQRMTNRLMYLAKLEATVLEVKVIEGHGTTIDVILSNGILREGDRIVLCGLNGAIATNIRALLTPQPLKELRIKSSYIHNKEVRAASGVKISANDLDKAIAGSRLMVVGPDDDEEEIKEEVMEDLEGLLNFIDTSGIGVSVQASTLGSLEALLEFLKQSKIPVSGIDIGPVHKKDVIRCSAMIERAKEYAVMLCFDVKVDKDAEELAEQLGIKIFTADIIYHLFDSFTKYQAEIMEKRRRESASDVAFPCVLKTIAVFNKKDPILLGVDVIEGVIRIGTPICAVKINPNTQERIIIDLGRIVSIEKDHKILNIVKKGQISNGVAIKIECSSQILFGRQVDEKDLLYSHISRKSIDLLKDIFRDDVSKEEWNLIRRLKIIFGIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTR7</accession>
    <name>M7NTR7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RPS0</name>
        <name evidence="11" type="ORF">PNEG_01367</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 33 different proteins. The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and at least 46 different proteins. Interacts with eS21.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with RPS21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873296.1">
        <property type="nucleotide sequence ID" value="XM_007875105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTR7"/>
    <dbReference type="STRING" id="1069680.M7NTR7"/>
    <dbReference type="GeneID" id="19895064"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01367"/>
    <dbReference type="eggNOG" id="KOG0830">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058171_0_1_1"/>
    <dbReference type="OMA" id="VKNFFEP"/>
    <dbReference type="OrthoDB" id="414863at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000010">
        <property type="entry name" value="40S ribosomal protein S0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03015">
        <property type="entry name" value="Ribosomal_S2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032281">
        <property type="entry name" value="Ribosomal_uS2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027498">
        <property type="entry name" value="Ribosomal_uS2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16122">
        <property type="entry name" value="40S_SA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS2 C-terminal" evidence="10">
        <location>
            <begin position="199"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00065690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR10667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="293" mass="32603" checksum="64612C24D4CB2D39" modified="2013-05-29" version="1">MGIFDAQPADIEMLISANCHIGSRNCELRMEPYVFKQRADGVHIINLGKTWEKLVLAARIIVTIENPRDIIAISSRSYGQRAVHKYALHTGAEAISSRFTPGSFTNYITRSFKEPRLIIVTDPRTDSQAIKEASYVNIPVIALCDTDSPLQYVDVAIPTNNKGRHSIGLIWWMLAREVLRLRGTLANRDVEWGVMVDLYFYRDPEETEKDTESEQKALEASGNPAGQFTSVPVTSDWEIAAQSAGAGIITNVASNVQSVGNWDENFGVETGVHSDWAADPIQQSEVQHAQNWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTW2</accession>
    <name>M7NTW2_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872767.1">
        <property type="nucleotide sequence ID" value="XM_007874576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTW2"/>
    <dbReference type="GeneID" id="19894555"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00857"/>
    <dbReference type="HOGENOM" id="CLU_2400618_0_0_1"/>
    <dbReference type="OrthoDB" id="5385543at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="93" mass="10548" checksum="5AE8611E056870F4" modified="2013-05-29" version="1">MATRARAEKGRFMAGNTELDIIPQKWKQEWVFHQSSKDGKSNNNIGFKTLCWVPVKDIETSESIKTSEVEDVPNLAGTMSSEENKEQKSVMEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NU63</accession>
    <name>M7NU63_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-specific glutamate dehydrogenase</fullName>
            <ecNumber evidence="4">1.4.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00964</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-glutamate + NAD(+) + H2O = 2-oxoglutarate + NH4(+) + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15133"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.2" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872877.1">
        <property type="nucleotide sequence ID" value="XM_007874686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NU63"/>
    <dbReference type="STRING" id="1069680.M7NU63"/>
    <dbReference type="GeneID" id="19894662"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00964"/>
    <dbReference type="eggNOG" id="KOG2250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005220_0_0_1"/>
    <dbReference type="OMA" id="DEYGMTS"/>
    <dbReference type="OrthoDB" id="184415at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056365">
        <property type="entry name" value="NAD-GDH_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016210">
        <property type="entry name" value="NAD-GDH_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055480">
        <property type="entry name" value="NAD-GDH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606:SF24">
        <property type="entry name" value="NAD-SPECIFIC GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23147">
        <property type="entry name" value="GDH2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23152">
        <property type="entry name" value="GDH_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000184">
        <property type="entry name" value="GDH_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="5">
        <location>
            <begin position="671"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1033" mass="118316" checksum="7A6619A0F031D675" modified="2013-05-29" version="1">MNYQSLTVPKEHIPVHLRMEITPQDHRLSDNTSGYSETHFEGKNEQMNLVSAHLEEQGFIPKNLVRNETIWFYQNLGIDDMYFQNESVNTIANHILALYSAKIMAYTRHSREFDIRLEREADDHAVYIDTSVPGETNFKGPLYEKRIEELYLNNSNATKAYRLETFRSSSLINPSTKQQLCSYFVTKCNFVNPTPSKEEMSDLRIVSDKTFLEKATQRTFNIYQSVVKSVLNRTGPVIEMYEISGTRERRIVIGYKQGSARSYFSALSNLYHYYGLTSTRKYVEQFSNGVTVICIYLVPVLEKLTQYPPIEHSIHQIVKEASLLYCIPENRFQAYFASGRLSLQEAIYAHCVFVFIGHFLNRLGTEYSSLSSILDLTNPIHSEVLAKLKRRLRQETFTRDYIFEIIQAYPELIKLFYVSFATVHYISSHKTVEELRPSLSYQRIQVSRILSEKEILDEVRRQTSSSHEYMVMEAFHLFNSHVLKTNFYQVTKVAISFRLNPDFLPEIEYPQKLFGMFLVIGSEFRGFHLRFKDVARGGIRIVKSRNKETYSINARSLFDENYNLANTQQRKNKDIPEGGAKGVILLDMEHQDKAVVGFQKYIDSIIDLLLEGKTPGIKDKLVDLYSHKEILFCGPDENTANLVDWATEHARMRGAPWWKSFFTGKTARLGGIPHDVYGMTSLSIRQYVLGIYGKLGLNEETVTKIQTGGPDGDLGSNEILLSKEKYVCIIDGSGVIYDPEGIYRPELIRLAKERKMISFFDKSKLSPSGYIVLIDDEDLILPSGEIVKNGTQFRDTAHLRFHADLLVPCGGRPEAINLSNVSQMIHNGKCTIPYIVEGANLFITQDAKVKLEEAGCILYKDASANKGGVTSSSLEVFASLAFSDDDFIQNMCIREGKVPQFYEDYVKQVQEIIQNNAQLEFEAIWRENKRSGKLRSILSDDLSSAITSLDEEIQQSDLWNNVPLRKVVLKEALPPVLLEKQGLDTILEHVPEPYIKATFGSFLASRFIYEYGADSSKFSFFQFMNNYLQKVNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NU99</accession>
    <name>M7NU99_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 15">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PNEG_00837</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 15"/>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872746.1">
        <property type="nucleotide sequence ID" value="XM_007874555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NU99"/>
    <dbReference type="STRING" id="1069680.M7NU99"/>
    <dbReference type="GeneID" id="19894535"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00837"/>
    <dbReference type="eggNOG" id="KOG3359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008438_2_1_1"/>
    <dbReference type="OMA" id="WAPYILE"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23283">
        <property type="entry name" value="beta-trefoil_MIR_PMT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF50">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="558"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="598"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="623"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="656"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="295"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="359"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="428"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMR10686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="699" mass="82853" checksum="0B3D515F867BB105" modified="2013-05-29" version="1">MVYNFNNLIGQPNIKLRINDIKYLIILTIIGSCVQTYMINHPSDLVFNESYMMQLAYNYIKKEFYIDKDPPYARMLYALFIWVLGHLPVNLYTIKKAYSLYRIPRIPTRLFSCIFGILLSPITYLTLRVMRFTRNTAILGSILIIFESSVVIQSRFVFHDSLALFFTALTHLFWRLFESCQQIPFRKAWWAYLMATGFTLGALISTKWVGIFTFFWIGLLACLQLWHFIEDLTMALTTWVKHFFFRFFSLIIIPTLFYIITFYLHINLLKNANDGVFLSPEFLSTFDNRIVKSVPAPVSYGSTVTIRHLNSPYGYLHSHFDSYPSGSKQQQVTLYLYEDANNNWLITDSGDANYEVFSFSTIQDGSIIRLYHLETNRRLHSHDVRPSLSDIDWQNEVSGYGHKGFPGDHNDLFRIEIDKSRSYTDESKISVRAIETKFRLIHVSTGCALFSNNIYLPEWGHGQIEVTCAKSGIYENSLWYIEDNSHDDFSINIEKVSYKKIAFFQKFFELHKHMWEENFHLEDLYNAGTHPFSWPFLRRGIHFWIKKNDQIYFLGNPLIWLLTLAFVGVYCIFKLFVILSEQRGYPSYNDKVYLRYDYLIGTSLLGWIFHYFPYYFMEKQFLLSQYIPALYFSILSLCSFWDFISVRFLQRLQIKLFTLFFFKIVISVYFIMAPLIYGYSMRKEHCSFIKFFKTWDLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUF0</accession>
    <name>M7NUF0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NGG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872791.1">
        <property type="nucleotide sequence ID" value="XM_007874600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUF0"/>
    <dbReference type="STRING" id="1069680.M7NUF0"/>
    <dbReference type="GeneID" id="19894578"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00880"/>
    <dbReference type="eggNOG" id="KOG4191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_533301_0_0_1"/>
    <dbReference type="OrthoDB" id="1232at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019340">
        <property type="entry name" value="Histone_AcTrfase_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10198">
        <property type="entry name" value="Ada3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="511" mass="59159" checksum="F7BA2EDDE920F87D" modified="2013-05-29" version="1">MGLLDDELAYGKLSEDRSLFSIYLTSNGLSNNTQGHDIPSIKQLLVLGESIKELLVKIQKKQSILQRKFQDFQIKYKKWLLHESEINDQVSQSETSIIVSKESSSNEHDNVFQISQLQNESIREEIESEEKKLLERNPPEFFKDIQMHQESLNTVFSNKEYVYDEILKISDPQKLKQYLGVSYFPTVDLSDKLPGEPVNEDFSKVKAPTQISISTYYAYLDSFYRPFSEEDLLFLKDEEEELTTYMIPPLGIFSENSWASEDLNGMISSNFSLSSIPYGSPDQLTDEHLFTEEISCGPLLERLLSGILKEDVLDEEQKIEEDEKDTDLYNSGWKIPTIKLDYHNFEERLKKELKYIGILGDDDINWNNREDDEISSNLRSLQSQLRHQCAINSARKSKLRELVKEHLAYQEYSIILNDLNKQVEQAFLKRSRSIEVKKKRVIGSIGSSDSGLGRIGLSNHIQTLLERRKKWVEKVGSIFTPIEKYTRLPTNTIYDDLDNIKTDENIIESDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUM6</accession>
    <name>M7NUM6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable endonuclease LCL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Probable endonuclease lcl3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PNEG_00934</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LCL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872846.1">
        <property type="nucleotide sequence ID" value="XM_007874655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUM6"/>
    <dbReference type="STRING" id="1069680.M7NUM6"/>
    <dbReference type="GeneID" id="19894632"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00934"/>
    <dbReference type="eggNOG" id="ENOG502RZZQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046484_0_1_1"/>
    <dbReference type="OMA" id="IYHTPGG"/>
    <dbReference type="OrthoDB" id="430293at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000029">
        <property type="entry name" value="Probable endonuclease lcl3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="16">
        <location>
            <begin position="69"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMR10786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="260" mass="30295" checksum="EDDEB77451401883" modified="2013-05-29" version="1">MYFWVKNFPNISENETNNSKEIQFFSSSIFVPTIFLTTAILILHKFYYQSLVRYPTASSIPVSLMNNKHILLGVVTSVGDADNFRLFHTPGGIFAGWHWLRSIPLSRKDLKDQTIHIRLSGIDAPELSHFGKEAQPYAKEAIEWLTSYILGKRVRVQIFNRDRYERIVGAVEIRKWPYIWIKRNVSLEMIKLGMAEVYKSHGAEYGGKSAELRFRHEEEKAKRKKIGIWKQSAKSYESPAEYKRRTFALLSYISPSKIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUP4</accession>
    <name>M7NUP4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase epsilon subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA polymerase II subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00958</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase epsilon subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872871.1">
        <property type="nucleotide sequence ID" value="XM_007874680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUP4"/>
    <dbReference type="STRING" id="1069680.M7NUP4"/>
    <dbReference type="GeneID" id="19894656"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00958"/>
    <dbReference type="eggNOG" id="KOG3818">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010628_2_1_1"/>
    <dbReference type="OMA" id="PEDGAWF"/>
    <dbReference type="OrthoDB" id="10254730at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140529">
        <property type="term" value="P:CMG complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045005">
        <property type="term" value="P:DNA-templated DNA replication maintenance of fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016266">
        <property type="entry name" value="POLE2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="8">
        <location>
            <begin position="340"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="630" mass="72741" checksum="68DFBA2E1FD3F073" modified="2013-05-29" version="1">MNEKLYEISENVVENSKIPLFLGVNIELSQLRPIAFRIFTKRYNLTLKSDALKELAIFIGRKFGQDWHTESESVLDEIAQLWKKSQESNFLVSKDLLIPILKKWNQLNYLKLKVQEQIPVLLENETLLNNSQLGAKLEEKIDIKQYYIYIDAFNQPKYIFDITHKSFERSNERPKILGDISHKISIYRERFYLIKQRLLSNPTFQEPGFYGSISHKEWHKITSIKNLLGRIGKEFMLLGVISYGPEGKLWLEDIDDRIMLETDDTINGGGWIVPGCIVLADGIYLENGTFQVFVLGHPPCEPKYLSEKSFDHIDFLGTNQNRLMKKQLKDAETKFSHVRLVFAADVILDDILSMKALKKMLYMYETRDDIFPEVIILMGNFISVPFHNTGFSANYKALFNSLALLLESFPKLTRRSTFIFLPGPNDPWAQGGAPLLPQRGIPKIFTNRIRKSCKHVFFASNPSRLLYFTQDIVLYRDNTMERLRRHSLCFNDINAPSINENKLNQTSENSNNDASTNNIMQNINKQKKCTSNHLSNLQQAQNLVRTLLDQSHLSPFSLSLRPIIWDFDHTLRLYPIPHLMVIADTSCLAFNTSYCGCLSINPGKLVNSYKASWAEYNPAENKVVIFEELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUS0</accession>
    <name>M7NUS0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872906.1">
        <property type="nucleotide sequence ID" value="XM_007874715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUS0"/>
    <dbReference type="GeneID" id="19894690"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00992"/>
    <dbReference type="HOGENOM" id="CLU_1807020_0_0_1"/>
    <dbReference type="OrthoDB" id="10484634at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="143" mass="17459" checksum="6D2F4158DD41F8B2" modified="2013-05-29" version="1">MNKNSKYKNQEKLLYKLNEYFLKFQKTLKTKLNENFLLNNEILRLENHLLEEIENFKEELDKIQQNKCILDLPISKTKDKLYQEIIYERKINYDMICLSIFEENDIENLKIEKEKFKKMIKNKEIDALEEFKDKLSKIVTSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUX1</accession>
    <name>M7NUX1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="10">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_00700</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="10"/>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872599.1">
        <property type="nucleotide sequence ID" value="XM_007874408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUX1"/>
    <dbReference type="STRING" id="1069680.M7NUX1"/>
    <dbReference type="GeneID" id="19894398"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00700"/>
    <dbReference type="eggNOG" id="KOG3964">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030471_1_1_1"/>
    <dbReference type="OMA" id="HKCLAQC"/>
    <dbReference type="OrthoDB" id="10250191at2759"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09135">
        <property type="entry name" value="PLDc_PGS1_euk_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09137">
        <property type="entry name" value="PLDc_PGS1_euk_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000850">
        <property type="entry name" value="Phospholipase_D_PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="402"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR11102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="503" mass="57942" checksum="DDA99A60CCD9B19B" modified="2013-05-29" version="1">MLFKGFIARELIPNAQNELKSSLQRVSEPVLEDLLEGLSQFAPSFVLSKEKITILTEPKEFFFTLKNKILNAKRRVFLSTLYIGKSEYELYTVLHKALSLNMDLRVSILMDALRGTREAPNPTSASLLVPLISLFGKHRVDICMYHTPNFSGLKKMLPSRINECWGVQHMKIYGFDDEVILSGANLSCEYFTNRQDRYHLFSSPQLTDFYATIHQFISSISYKVVPSDSPEKVALVWLKDTNCPEPTKDPENFRRHSTSALLKLLKPTPINTNEVFSTIVYPLFQFSPIFKPYDFSTEKKGICLILDTFLSSQSSDYDWIFTSGYFNTHKDYSKRLLTSNSKGCVIVSSQQANSFYNSPWPSKMIPSAYSFLAERFLLNVYKANKQNNIHLEEWKNGRYGEGGWTYHAKGLWIMPSPENKAKGRKPYITFIGSSNFSRRSHSLDLEATALIITFDTELQKSLRDEIENFRSYSKKVNLNDFSSPDRKTGWFVKFCVWILGRMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7NV46</accession>
    <name>M7NV46_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872663.1">
        <property type="nucleotide sequence ID" value="XM_007874472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NV46"/>
    <dbReference type="STRING" id="1069680.M7NV46"/>
    <dbReference type="GeneID" id="19894459"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00761"/>
    <dbReference type="eggNOG" id="ENOG502SC64">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1482598_0_0_1"/>
    <dbReference type="OrthoDB" id="5363417at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742:SF3">
        <property type="entry name" value="RIBONUCLEASE MRP PROTEIN SUBUNIT SNM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="182" mass="21868" checksum="8D03B5BAC932A0C5" modified="2013-05-29" version="1">MNTLSLAELHHLRRLSYSALPFSFELSSYFMSVFYENIRHHGISLSEIHDKTACLSCGMIWIPGWTCTIRLRRSSAKRYWHQKRTKMEYPKLNYWVEYKCQRCDRITKFQREKYVIKNKSTNILLERPSETSKEAQTHSRRNVNTRRRKKIRLGGLEGIIDRMEKEEIKKMEKGLSLEDFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVJ9</accession>
    <name>M7NVJ9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872214.1">
        <property type="nucleotide sequence ID" value="XM_007874023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVJ9"/>
    <dbReference type="STRING" id="1069680.M7NVJ9"/>
    <dbReference type="GeneID" id="19894039"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00341"/>
    <dbReference type="eggNOG" id="KOG1211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_7_6_1"/>
    <dbReference type="OMA" id="DSKDATC"/>
    <dbReference type="OrthoDB" id="421993at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR11312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="366" mass="40747" checksum="A22122B4D78EFB4F" modified="2013-05-29" version="1">MDEFGIGFSTTNLLFGSTLNPIDLKVPRSSGGSSGGSAAAVSADMCYISLGTDTGGSVRHPASYCNCIGFKPSYGLISRWGVVAYSNSLDTVGIFGKTIERIRETFNILNVYDPKDPTSLPINERLKIKQFNKNKRITIGIPLDFNISEISQNLRDIWKKAIKYLEFKGFNTTTVRLPNIKYSPMVYNIITSVEASSNLAKYNGLVYGHSANTDINENIFQKTRDEGFGDKVKQKILIGTYFSIHNNYFERAQKIRRLIQNDFNNVFNSFKKYSKTTQENKVDILITPSTIGSAPLIENVVEEISLLHLYLSDFFTISANLSGIPAISIPFSYDQDGLPIGIQLMAQYGCDNLLLDVAEILEQKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVQ8</accession>
    <name>M7NVQ8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sec20 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_00407</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SEC20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872283.1">
        <property type="nucleotide sequence ID" value="XM_007874092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVQ8"/>
    <dbReference type="STRING" id="1069680.M7NVQ8"/>
    <dbReference type="GeneID" id="19894105"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00407"/>
    <dbReference type="eggNOG" id="ENOG502S7WD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1066049_0_0_1"/>
    <dbReference type="OrthoDB" id="46868at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005606">
        <property type="entry name" value="Sec20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825">
        <property type="entry name" value="BNIP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825:SF0">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SEC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Sec20 C-terminal" evidence="11">
        <location>
            <begin position="75"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR11382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="261" mass="30661" checksum="D023E5DCC5697CCD" modified="2013-05-29" version="1">MKSRYLEICNKLKEDLKIARIDFRKALLKSNKNINLTFQKNQEQLLGDTKERVTLLQRKRENMKSSTGDRVINTSTNVLSALVELHQLMESEMSRSSVTLEELELSSNALQSLQENYLTFNTLLTKSRKLISELEYSNKFDRISIIFSLILFLSVIAWIIYRRLLHHIVRFTFWFFFVKLRNIGKKIIKTRSNEYFLINIFILIIVGKFSVSDSLKVPENSIIQKSKPIFSYSKNYTGDFLEFNTIYKSDIANSTFLHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVS5</accession>
    <name>M7NVS5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="9">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NAT10</name>
        <name evidence="15" type="ORF">PNEG_00425</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with TAN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="9"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872303.1">
        <property type="nucleotide sequence ID" value="XM_007874112.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVS5"/>
    <dbReference type="STRING" id="1069680.M7NVS5"/>
    <dbReference type="GeneID" id="19894123"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00425"/>
    <dbReference type="eggNOG" id="KOG2036">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004652_0_0_1"/>
    <dbReference type="OMA" id="HLHYIMS"/>
    <dbReference type="OrthoDB" id="10067491at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051392">
        <property type="term" value="F:tRNA cytidine N4-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016556">
        <property type="term" value="P:mRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11040:FF:000002">
        <property type="entry name" value="RNA cytidine acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TmcA/NAT10 N-terminal" evidence="12">
        <location>
            <begin position="8"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="TcmA/NAT10 helicase" evidence="11">
        <location>
            <begin position="280"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="13">
        <location>
            <begin position="542"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="Possible tRNA binding" evidence="14">
        <location>
            <begin position="776"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1029"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1045"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="642"/>
            <end position="644"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="649"/>
            <end position="655"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="742"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR11402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1057" mass="121373" checksum="2E1133F72E19DC90" modified="2013-05-29" version="1">MMKKKQIDSRIPTLIKNGVQEKKRTLFVIVGDRGRDQIVNLHWLLSQTRIASRPSVLWMYKKDLLGFTSHRKKREAKIKKEIKKGIRDPNEATTPFELFISVTNIRYTYYKESEKILGQTFGMLVLQDFEAITPNLLARTIETVEGGGIIVILFKTMENLKQLYTMTMDIHSRYRTEAHQDVVARFNGRFILSLGHCSSCLFVDDELNVLPISEAKKVKPLPKPQLEEPKKELEELKQKYEDKQLLRSLIDVAKTVDQARALITFVEAISEKTLRSTVALTAARGRGKSAALGLAISAAVAYGYSNIFITSPNPENLKTLFEFTFKGFNSLKYEEHIDYDIIQSLNPSFNKSIVRVNIFRNHRQTIQYIHPSDAYVLGQAELLVIDEAAAIPMPLVKKLLGPYLTFMASTVNGYEGTGRSLSLKLIQQLREQSRGFAHENTKSGNSEKSMINRSEKLNKESGINSIGGRKLREITLEEPIRYSYGDPVEEWLNKLLCLDINISLKQFLEQGCPHPSQCELYYVNRDTLFSYHPVSESFLQMMMSLYVASHYKNSPNDLQLMADAPAHQLFVLLPPVKEDDNKLPEPLCVIQVALEGEISRESVVNNLTRGYRTGGDLIPWVITEQFQDDKFASLSGARIVRIATNPEYIRMGYGSHALKLLENFYEGKYLNLSEETISESNENIKIINNNLESSLLTDDIKIKDLKIMPPLLLKLSEKKPGLIHYLGVSYGLTPQLYKFWKRAEFIPVYLRQTPNDLTGEHTCLMLKLLQDKSETWLNEFSNDFRKRFLSLLSFSFRSFPTILCLNIIESINNDLIQKDNVHVITKSEIDINLSPFDLKRLESYANNMLDYHTIIDMLPYIADLYFKGRFGKDLKMTGVQSAILLALGLQKRLLEDIEKELNLPSNQVLAMLVKILRKLSSFFKDIYYKAIDNTLPIERKNLKNQLQTHADENDNFRGFIPLKATLKEELDHLSSEMEDSIKEKQRELINSLDLQKYIIKGQEEDWDKAEQHIKNGIYSGKSSVVSIQSHSLKREHESLTDIPHIKKKHQKKHKRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVZ6</accession>
    <name>M7NVZ6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">UBA4</name>
        <name evidence="15" type="ORF">PNEG_00497</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872383.1">
        <property type="nucleotide sequence ID" value="XM_007874192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVZ6"/>
    <dbReference type="STRING" id="1069680.M7NVZ6"/>
    <dbReference type="GeneID" id="19894195"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00497"/>
    <dbReference type="eggNOG" id="KOG2017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_1_2_1"/>
    <dbReference type="OMA" id="IPDVGMD"/>
    <dbReference type="OrthoDB" id="10261062at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070566">
        <property type="term" value="F:adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042292">
        <property type="term" value="F:URM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007114">
        <property type="term" value="P:cell budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000220">
        <property type="term" value="P:regulation of pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000033">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03049">
        <property type="entry name" value="MOCS3_Uba4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028885">
        <property type="entry name" value="MOCS3/Uba4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF102">
        <property type="entry name" value="ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Rhodanese" evidence="14">
        <location>
            <begin position="340"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate; for adenylyltransferase activity" evidence="12">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate; for sulfurtransferase activity" evidence="12">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="164"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR11482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="431" mass="48331" checksum="24F6C63B82E3AA96" modified="2013-05-29" version="1">MDSEIKYLKKKIKELKLELSNKEKVLKQNINNKKYNGLYLEEFKRYGRQIIIPEIGIEGQKTLKAAKVLVIGAGGLGCPALTYLTGAGIGTIGIVDGDCVDISNCHRQILHTSSKLGQKKVNSAIEYLEDLNPFVKFVNYSTHISPSSAIDIIKPYDIILDCTDNQSIRYLISDTCVLLKKPLVSASAIRTEGQLCIYGFRGSCCYRCLFPTPSPKETDQTCEGNGILGMVVGVMGTLQALEVIKILLSQQLLSEYNNIETNNYVSYMTIFSAFSVPQFKFIKLRPRKSSCPSCGDKPLITKNIIEEGSYYNLNTICKEEILEKEQRITAQGNSIFQSKKRSQIILIDVRDETQFKTCSIPFSINIPLADLYNLPCLPIDKNKQIYVICKSGNNSQLAVKLLYERFDISNVKDVIGGLKSWSTINKEFPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWA8</accession>
    <name>M7NWA8_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00444</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle</location>
            <location evidence="6">COPII-coated vesicle membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the VMA21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872322.1">
        <property type="nucleotide sequence ID" value="XM_007874131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWA8"/>
    <dbReference type="STRING" id="1069680.M7NWA8"/>
    <dbReference type="GeneID" id="19894142"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00444"/>
    <dbReference type="eggNOG" id="ENOG502SBNA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154717_0_0_1"/>
    <dbReference type="OMA" id="FEGNATF"/>
    <dbReference type="OrthoDB" id="160405at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03058">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019013">
        <property type="entry name" value="Vma21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792:SF3">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09446">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="92" mass="10652" checksum="8A950C905FF62EBF" modified="2013-05-29" version="1">MTSQDAEQIDKIAKKYVLIKFFLFSTAMIIVPISSYYLSLRYIFKQNNTIYAAIVAVLMTNIVLIGYIILALIEEKDSQMREKSEIISKKHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWB2</accession>
    <name>M7NWB2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00031</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871882.1">
        <property type="nucleotide sequence ID" value="XM_007873691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWB2"/>
    <dbReference type="STRING" id="1069680.M7NWB2"/>
    <dbReference type="GeneID" id="19893729"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00031"/>
    <dbReference type="eggNOG" id="KOG1703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_484934_0_0_1"/>
    <dbReference type="OrthoDB" id="1112565at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF65">
        <property type="entry name" value="PAXILLIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="482"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="143"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="230"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR11587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="562" mass="64981" checksum="079D16EB3BA0FA7B" modified="2013-05-29" version="1">MTSVSKLRISNILPPIKCSNCEEYVQLSKMGEHICEKTKEIYQKNFKNYAYSSSFPEASKSPLGSNKEMNDISLFTSSHNKSVSSSEVTYKDDEISKKENCQKKRHIFERLNTVTPGPLGLRNHSDLKNTKCMESERSCKDSLVQGVQDKSAKKRSARLQPYRWPNSTSSQSSISMFDSSPSEKNCIDSMSQKKNKDDIEVNYEQMISPTCENIEKILTLKDKSNLTEYTRDRSSCTEKKSKTRNETHLRQNSRKESRFPDENSERYLIEWARRDKELSSKFIEKTPNPVISIQECNNKNIHSRPFNEKKIYNNKHSYFFERNSNSTAFSTSSNISRDGKISSCSISSPNSEISVSNLQKQNVISKDELHTGSFDKTFNDPENSLHMFHARSDDILAFHINNTSQKNIIRNKYLSDFYCKRCNKYIEGKSIRCSDGKISGRFHRECFKCFNPNCQNLFTTSEVYVFEGEPFCSKHYHILNNSLCTACGEGIEGKCFQTETNDKYHFYCFTCYSCKKPLNGEYFDIDGKTYCENDVAKLLTLKMLPYQRLEKRKTKILTMGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWB7</accession>
    <name>M7NWB7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynactin subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00036</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871887.1">
        <property type="nucleotide sequence ID" value="XM_007873696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWB7"/>
    <dbReference type="STRING" id="1069680.M7NWB7"/>
    <dbReference type="GeneID" id="19893734"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00036"/>
    <dbReference type="eggNOG" id="KOG3121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088622_0_0_1"/>
    <dbReference type="OMA" id="SQIHGTQ"/>
    <dbReference type="OrthoDB" id="417208at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03359">
        <property type="entry name" value="LbH_Dynactin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047125">
        <property type="entry name" value="DCTN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126:SF1">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21711">
        <property type="entry name" value="DCTN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR11592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="180" mass="20034" checksum="4645663581D77259" modified="2013-05-29" version="1">MVKSKEYIETDTGNKISRLRTTILGSQNIILGGKTVIQSECTIRGDLRRFDSNSDTIAIIIGKYSFIAVGTVIRPPSKMHQGVFNYYPIKIGDFVQIGEGSMIEAASIGSYVKIGKECVIGKFCIIKDCVEIREGTILPEHSVIPSFSIVEGRPGLVIEELPECTQELFEKECRTKYHEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWD6</accession>
    <name>M7NWD6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ML-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00474</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872357.1">
        <property type="nucleotide sequence ID" value="XM_007874166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWD6"/>
    <dbReference type="STRING" id="1069680.M7NWD6"/>
    <dbReference type="GeneID" id="19894172"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00474"/>
    <dbReference type="eggNOG" id="ENOG502R5MY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_399638_0_0_1"/>
    <dbReference type="OMA" id="GCFQAVM"/>
    <dbReference type="OrthoDB" id="5377623at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF7">
        <property type="entry name" value="TRP-LIKE ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="529"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="8">
        <location>
            <begin position="21"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="629" mass="72834" checksum="FFC1B0151B3ECD10" modified="2013-05-29" version="1">MLLLCISSVFAFQNHIALVDNIFYSKNYESCSDHSLIEISYFSGKYHHRERLMEFEMSGKSSVNDKIMSILNFYPKVKLKKTVTFLFTVHEKIHINQTYDPCVIKIPGLCSISSTPYFLTKGVLPLSAEKTNVSEFFFNIPDFEGKVYFYFHSTVTGEEIGCLKTSIVNKQSFRNNIITWICLGFFGLSAFISFMAFSSQSSFSYALLAASHSIPGLLAFWSYFQFLASITMENVIYPTSLIAWASNFSFSLGLIKFFQELIYLFNKFSEKHIHLTLGNVKEKQNNNKFVLSNSYQGIQGQLNYLKIANTNAFITSITCFVSAVLGFLVISTIACLITRIIRRNEIFIRRNWINFNLWSILRLLVINIFGISFISIYQLALHDTYQPKILSTLSLLVFVVPILILSSLHFFRSHFRKLDSEMTAKYWGWLIVEYNSKRQHFYLVFFIYSLCKAFLLGLFNFPSKAQTISLSAVELLYLLSILILFPFESIRAYTLELLLGAIKTSCLGIIITFSFNISELSRALLGMTIIMISTIGLLTLFIFTLWNFIIVFLLATYKDHINYDSFETNTLSDRIHNYKQKIFKHKKFGKVFGYDQYLYPQKKYYTYSSQSSDSTLHNSEKYYIKQYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3F9</accession>
    <name>M7P3F9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial GTPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_03205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Mitochondrial GTPase involved in assembly of the large ribosomal subunit. Plays a role in expression of the mitochondrial translational machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875268.1">
        <property type="nucleotide sequence ID" value="XM_007877077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P3F9"/>
    <dbReference type="STRING" id="1069680.M7P3F9"/>
    <dbReference type="GeneID" id="19896892"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03205"/>
    <dbReference type="eggNOG" id="KOG2485">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011106_0_1_1"/>
    <dbReference type="OMA" id="GVLWPKF"/>
    <dbReference type="OrthoDB" id="269151at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016478">
        <property type="entry name" value="GTPase_MTG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782:SF4">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006230">
        <property type="entry name" value="MG442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="5">
        <location>
            <begin position="124"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="71"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="132"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006230-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="298" mass="34118" checksum="A580B9F52662F7AF" modified="2013-05-29" version="1">MTIFLPRYNYHYNLKRSWFPGHMFSGLKDIKDLLNDIDLVIETRDSRIPISCENKLLNKAIEKKEKIRIFNKYDLLDCDSKRKFQEKFYENGIFCSINDPKSMKKICESIRIKALKLNKISGMNVMVVGMPNVGKSTLLNSFRHIGLRSIDMYQKNRKAVKTGAQPGITKKITQKIKIIKKPLVYCIDTPGIMIPSINDPITFLKLALVGCIKDNIIDIITVADYLLFRINLINPELYLTPFKMKQPTNNVEELLNAIAIATGCLKKGGIPNIYTAATFLIKKYRTGNLGKFILDDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3Q5</accession>
    <name>M7P3Q5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_03316</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875392.1">
        <property type="nucleotide sequence ID" value="XM_007877201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P3Q5"/>
    <dbReference type="STRING" id="1069680.M7P3Q5"/>
    <dbReference type="GeneID" id="19897003"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03316"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002678_91_2_1"/>
    <dbReference type="OMA" id="HYNAVHD"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="67"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="97"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="127"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="251"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="282"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR08490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="374" mass="44426" checksum="FB9095B82B15C997" modified="2013-05-29" version="1">MFLNTNFIKDLEEENTKITKRTIEEDFEKKKRQKKIYKCTFEGCNKAYSKPCRIEEHIRSHTGERPFVCNYKGCEKAFFRKSHLKAHIHSHINERPYFCRFKDCIARFNTNQHLKRHEAIHLRETPYKCTKYPPCTAEFHKHHQLLIHIANTHTHKKPFLCEYDQCKKSFDTGSKLNSHISRIHVPIPSYFCEIEDCNQKEGFSKLSLLQKHLKNDHCVICKVCNKKFSTNTQLKLHLQVHEKSLEERRLYHCSINNCQKSFTRSFALQKHIEIVHEQKKEFVCNIDNCGMKFGYKKLLIAHKLYLHNQSEENYIKKIRSKVAAKVGPVSLLTGFDYSESGRDISCLVQGCKWQFLREYDLKRHIKSYHSDIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>M7P484</accession>
    <name>M7P484_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Serine/threonine-protein kinase Tel1</fullName>
            <ecNumber evidence="4 16">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PNEG_02845</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 16">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Chromosome</location>
            <location evidence="16">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4 16"/>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874883.1">
        <property type="nucleotide sequence ID" value="XM_007876692.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7P484"/>
    <dbReference type="GeneID" id="19896532"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02845"/>
    <dbReference type="eggNOG" id="KOG0892">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000178_8_2_1"/>
    <dbReference type="OMA" id="HACSVIR"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05171">
        <property type="entry name" value="PIKKc_ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038980">
        <property type="entry name" value="ATM_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044107">
        <property type="entry name" value="PIKKc_ATM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021668">
        <property type="entry name" value="TAN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11640">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01342">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="16" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="16" id="KW-0779">Telomere</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="18">
        <location>
            <begin position="1834"/>
            <end position="2421"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="17">
        <location>
            <begin position="2525"/>
            <end position="2835"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="19">
        <location>
            <begin position="2846"/>
            <end position="2878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMR08665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="2878" mass="335367" checksum="A3EF5B5B4EF3A796" modified="2013-05-29" version="1">MTEASLFNICEQLLSEKPKIRIDGLRNLKFILNNSRKMQFVGEKCYQRLLECLIKAVAFEKYSSIQRGKLNNSMTFARLQEYGVVLRSVIELGNKFLKVKTFSLVLNHIIDTLSISEETLYQALSIDYIKCLKLILSYPPHVEHLSVNEWEKLILFCSSFIINLEGSFSFSDKNVLSSDIELLEEYRQPLKHVQRIKHESIELMYCLQVLVSWSSAPISDCLFNLVNFLLNFLSFYSSETNAHLFAFTALNSVIQKIMINNFEFLFQVAHTMIKLCVKLWNTKSFLLKNQLIIGLLLAYPHWYRGFNELCRNVLETDLINLFHCIQADYITLQDKEMLSINDITLHSPILKGNVGSFFCFSSSLRCLDLSLTSKKSEQYFFILQIAASIIQIFESKGSNFLKYICKNDNDESLKVHQVLSFFEKFGYNVSRSSNSTKIFWLQIMVFFFERAEVCFCDDFSIILRHFINLLSDNDAIVQTWALLGIGSFVSWKKTYHHANCLISDVLVNTDILQLCLRKSAVPITCRSACHVLSLFLELDLVDTAMMLSVFRHVFDSIEINGPAIISGDSYRFLLLLLFRLEQNNCLVGINGSLCLLQWFLSRWNSMDFLKGSNICYFSNFSVHVEFLISCCLNSGFVIKNRQNCQFGSIGLFSLRQNFFKNVLLYFLIQELNISDEEDLYDEFEVLRNKIVLESKFIVLERVMFIILPIQNTVKTVHSRWTELLKESTHINVDVFRLFVEFSFIVILFTYFILSINKNMDEFIEISLNLVKEIIKFLASESCSRDQIDTVLYCLNGIFRLSFEVSFTKENSYLNKTSLNLFRQEIYALLQILKQRSSFFQLQDSSRVIMDDDDDRPLIVYQENIEKYIPFLRNYIDAKYSVNSMKASVLLYLEFVLLGSESLDIFNMSGFHLQKSVLFILFKNQIGDNLIQLGFFLISYLLSSIDKMTEDDISEILENFAKTYLTQYEFERSDVVLMVSADLLMVIVKKWLTSENNSPLRKVFGKILEWILKITLENCLASFYARIRVLKLLNSIYNISKDHGLSLKSLNIAPNEIFLQLLKDHDLGILYSAVMMIKFVFQEYDPIEHSRVYFDIISQLEINEEKFEKIALRALILSNILVVSEYVRKAAFYNLIELGKLDSISLFVLKCLQWSCKILSLKSELSLFNAYRSQVIWSWLNFEGKLDNFPFKVLNFSSNINFYSSNFDEIIPQLILFGKNEYLIDISNLIQVSLKKEIRDAFHKIVGYVLLSYNEKNMDSALIFDSFCKNYLDDEEFTYLLRSKFPMILSVLFGSMKDEMFISKIFCQFDLKNEAINFDEISDFGISDSFFPEPSRPFYKVGCILKSIWDLCKYSDMPMYKLNDVYIIAYIFRYLMLHCQLGTSLSEKCLHLRKFRVFMCLLDRSLIRGYILKVLLQGLLEYLCFPECFIDVSGMLRYLLMCGYRCHDFSTIRSTVFLNVIMSLIRYGVVNIKSNCFNSIIINRLFAWIIEYCDLIAKIQELSSISSFLKSYYKVMICSEEFSSAKPRHIMTLSESLLNNIEFFDKNSALILLEVFQKDSTVLLSESDKFILIKKILFSICDMSKISLSLLHYGARVLGQWYVRNKIINKAIYFELMNRKKLSSFKVRTFKDPRFDILSTVFSLLNKGDHTILIIVEKTLRNIFERISSEVFDEFVGYEYRDIATIYISNLFVSEKNQSLEHFSVEFNEYYWKDKTILFSDWLKFLLLTILYNFNNDFVFGCLGDLVEHVTGFSEKIFIFSVDYLLLNKDIGESIKIIAVLNEIVNFVFSQYEDAFYRPHICLMIEMILYLRSQPSEIHYSGFDLNFRLEINYFNAALAAASCQFWETSLLFIYIHWTANDSIIDDEMLKLLTVVYKKINDPDSFYGIPYAVSLENILSRHKFEGNGWKSLFLHGAALENDYRMSSSMTKNEHVFGVMEAFDMLGFRSFSRMNFFYFRNNVTVGFLKDQYSSSWRLEQWDLPCSPLSSNLDHVIYNILQLVNKDAEQNVFFNILDIGYSMMVDFEKYPVLSDKRITGLIMLTEIEEIFLCSSFADVWFRWESRLSISNPSIKFVSIEPILSLRQVLLSSILKNSSFIKYSVDKSLIRNCLIKTLVELSHVARINDNLQIAFSAITYAEKLLKLDLKVNSELLSPVVIEISRVLWDQGDRINSVKLLREIVSDKDIDLSRKHEISPELLAQLASWTSVLRLERSDFIMEKYLKHAVRLLGDKKYGNEAGYVFHEFGFFCDKQLESLNNHDDFERIQKLRKQKSEELAVLDQMISNASFYDKKALLLHRDKAKALFDIDDIEFNRLIENKEIYLRKSIKNYLRSLISCDNYDHNISRCMSLWLSNVENDAVNQTVRKLIYNIATHKFLRLFTQLASRLSENKSYFQFILHELIKHICVDHPYHSLFYLVSLRHTVNKDDKLGLLRKKAVDAVLSELSLPNALGDMLRQFMNLCSAYADFAIYKMKKKEYGTSKISFSVYPKFNVFLEDIPKYRLPPPTMDISIRSDCNYNDVPVISHYSPYFMLASGISLPKVIECVSSDGKFYKQLVKGGNDDLRQDAIMEQVFLQVHAFLQKNRLTRQRNLGIRTYKVLPLTKNAGILEWVLYTFPIQDYLHPAHEKYNPKDWTPDQCRKAIDCVSKKSKEIRFQTYNRVVSHFKPVMRHFFMDHFSDPKDWFQKQLNYTRSTAVISMLGYVLGLGDRHGHNILIDKTSGEVVHIDLGVAFDQGKLLPIPETVPFRLTRDIVDGMGIIRTEGVFRRCCEFTLNVLREEAFNIISILETLKYDPLYSWTISPLRIRKIQENETLVNNIDNDFNNVKENSIDGAEAERALLIVSQKLSKTLSVEAAVNELIHEATNPNNLALLFCGWAAYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7P519</accession>
    <name>M7P519_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase</fullName>
            <ecNumber evidence="4">4.1.3.44</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">tRNA wybutosine-synthesizing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PNEG_02729</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:36347"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10165"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="EC" id="4.1.3.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TYW1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.44" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874756.1">
        <property type="nucleotide sequence ID" value="XM_007876565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P519"/>
    <dbReference type="STRING" id="1069680.M7P519"/>
    <dbReference type="GeneID" id="19896420"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02729"/>
    <dbReference type="eggNOG" id="KOG1160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007952_1_2_1"/>
    <dbReference type="OMA" id="FHVNGKW"/>
    <dbReference type="OrthoDB" id="271553at2759"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102521">
        <property type="term" value="F:tRNA-4-demethylwyosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000196">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034556">
        <property type="entry name" value="tRNA_wybutosine-synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930:SF0">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE TYW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00284">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01071">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="17">
        <location>
            <begin position="119"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="18">
        <location>
            <begin position="377"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMR08950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="719" mass="83071" checksum="053917D705C1AB8B" modified="2013-05-29" version="1">MFLLLYQLWKSYRVFIAICLILIYTLYFLILYFQQKTSLIDKKLSILSNSSKGNDVICSKDDKNDFNTEISKSVKIRTPKRFIRSLAKYPKALNVDENTRQSFVENNRQAIVDVNDIYVSILYQTLLGSTEKYAKLLYDIISPHFEKQVLLENIDFVEDFDDYFVSPENPESRIFIFLIPSYETDSPVDLLLSTLKDILYDFRVGAIPLRNLKGYAVLGFGDENEWPGQKFCYQAKDLDQYMFKLGARRIVSVGCGNVKGDITNDIQAWANVLLNAIKNGTMPELISDVSEESENEPFEDNEDSVVDMEDMGMLMKTKKTEPGELKPKEMVSKSSPTYKSLVKQGYTIVGSHSGVKICRWTKSALRGRGSCYKYSFYGIRSHLCMETTPSLACANKCVFCWRGHTNPVGTSWRWKIDKPEDILFGMMEGHYNKIKQMKGIPGIRPERLKEAMRIRHCALSLVGEPITYPHINELIKMLHDRKISTFLVTNAQHPDALENIGQVTQLYVSIDASTKDSLKKIDRPLFKDFWERFISCLEILSRKQQRTVYRLTLVKGFNTEEVEQYAHLVSVGKPCFIEIKGVTYCGNTHSSLTMKNVPFHEEVVGFVKALTKKISEMDNVPEYDIASEHVHSCCVLIAQKKFYINDKWYTHINYDRFFELAESNMPFSEMDYISETPHWAYFNSPYGGFSPDDIRWKRKNAKNVNFKREEIGLQNNTEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>M7P5E1</accession>
    <name>M7P5E1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02444</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874452.1">
        <property type="nucleotide sequence ID" value="XM_007876261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P5E1"/>
    <dbReference type="STRING" id="1069680.M7P5E1"/>
    <dbReference type="GeneID" id="19896137"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02444"/>
    <dbReference type="eggNOG" id="KOG0242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_21_1_1"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061673">
        <property type="term" value="C:mitotic spindle astral microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005880">
        <property type="term" value="C:nuclear microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070463">
        <property type="term" value="F:tubulin-dependent ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045144">
        <property type="term" value="P:meiotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099606">
        <property type="term" value="P:microtubule plus-end directed mitotic chromosome migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007079">
        <property type="term" value="P:mitotic chromosome movement towards spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031115">
        <property type="term" value="P:negative regulation of microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070462">
        <property type="term" value="P:plus-end specific microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032888">
        <property type="term" value="P:regulation of mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01370">
        <property type="entry name" value="KISc_KIP3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000053">
        <property type="entry name" value="Kinesin family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF13">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF19 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="5"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="839"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="391"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="492"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="873"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="890"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="132"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="900" mass="102103" checksum="497B8E5026D8ECF6" modified="2013-05-29" version="1">MSSSSVSVTVRVRPLNPKETSQLQINNNEVSSFIGDGSFTGSSIQKNPPKGLRRIVQVLDERVLIFDPVDTNPMARFQKTLLPVGKRVKEIKYAFDRVFDENATQEMVYENTAKPLLDGVLEGYNATVFAYGATGCGKTHTISGSPEDPGIIFLTMKELFDKMTSLADEKIIEITMSYLEIYNESIRDLLVPSSIAKPLSLREDSDKKIAVPGLTSYRPQSVNEVMEIILKGNANRTISPTEANSVSSRSHAVLQINVAQKPRTADISEEHFGATLSIIDLAGSERASVTKNRGDRLLEGANINRSLLALGNCINALCDPHRRNHVPYRDSKLTRLLKFSLGGNCKTVMIVCVSPCSTHYDETYNTLKYGNRAKNIKTKVSRNMITVDRHVSQYVKAIYELRQEVSELKKKLEDKKSEENDRISKKYAFFDIKLNEGIHKLHTTFEKLSSLKEQYLLNMNLLLSLENQFEIINSWLIAFDIISNANLDDETISQFKFTKELAKNLLNNLENKRQITLQEISKTTINKDFETTCDEILKELREENLNETLINLFLKEAKIIKITSERDTLLKERANFQTIMEKTYSMMQQFAKSSFEGLNISVLMLKNKDKNLITQVSLEEKFKSSCKTLADIIHQFSSKTNTSFEGETDTNEFIKPSSPFLRACFKKPYLQISSPFQIKSPKTFKVHTPKKNVMFHKGKNVFKKKKVRWNDQPSDTEMNNTKDDLTESDSHVLSDLKINITPKTTPTYSLESQNRMLSEADNIIFSHINQDDQENSFIESDYETGNIIENINSPKLRSALKKTDKIIARVCKRNRLSSNITEISTKPILRGLKFDKENLKSSPTQESPRSRTFAVGNSIGGSIRVSNPAAVFKETKDSSSISRTEKSELNKPQINNKPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6L0</accession>
    <name>M7P6L0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Complex I-ESSS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase ESSS subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PNEG_02106</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Complex I is composed of 45 different subunits. Interacts with BCAP31.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB11 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874088.1">
        <property type="nucleotide sequence ID" value="XM_007875897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P6L0"/>
    <dbReference type="STRING" id="1069680.M7P6L0"/>
    <dbReference type="GeneID" id="19895800"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02106"/>
    <dbReference type="HOGENOM" id="CLU_2134596_0_0_1"/>
    <dbReference type="OMA" id="RIQTWAL"/>
    <dbReference type="OrthoDB" id="2147978at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019329">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ESSS_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10183">
        <property type="entry name" value="ESSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMR09520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="113" mass="13677" checksum="19775D372F6C3F4B" modified="2013-05-29" version="1">MFLHKICQFSIKNTKYKYIRRHLDKTSIYYFLKDDFPGFSRVRYASGTPKYYEPTSVLFGEETENQDWRTIWKYGMGGFMLIATILYIYKPKTGIRIWALEEAKKRIYSEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7P7R7</accession>
    <name>M7P7R7_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01665</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873627.1">
        <property type="nucleotide sequence ID" value="XM_007875436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P7R7"/>
    <dbReference type="STRING" id="1069680.M7P7R7"/>
    <dbReference type="GeneID" id="19895359"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01665"/>
    <dbReference type="eggNOG" id="KOG0265">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_2_1"/>
    <dbReference type="OMA" id="IWDIRPY"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052234">
        <property type="entry name" value="U5_snRNP_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006:SF1">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="98"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="140"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="189"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="224"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="274"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="316"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="351" mass="39164" checksum="DCFDD581411471C9" modified="2013-05-29" version="1">MDKRKEAPYDEKEDNMLMKRVKVISDEVVKSKDKQNTLIESIPRTSGLKAPIMQLTGHQGEIFSCRFDLSGRYIASGSFDQLILVWNTYGDCSNFGQLKGHKRAILDLQWSRDSRVIYSASADQTVGTWDLETGQRLRKHTGHEDIINSITTVRRGTEFLATGSDDTTISLWDGRQKNAVDYFDAAYAVTAVAFNEEGSQLFSGGLDNDIKVWDLRKRSIIYKIVGHVDTITSLQTSPDGNFLLSNGMDNTVRIFDIRPFVPSSRQVKVLKGALHGIEKNLIRASWSNDGLRVAAGSADRTVIVWDVSSGKLTYKLPGHKACVNAVDLHRYEPILLSASSDRSLFLGELSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7P881</accession>
    <name>M7P881_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01834</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873807.1">
        <property type="nucleotide sequence ID" value="XM_007875616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P881"/>
    <dbReference type="STRING" id="1069680.M7P881"/>
    <dbReference type="GeneID" id="19895528"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01834"/>
    <dbReference type="eggNOG" id="KOG2000">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003736_0_0_1"/>
    <dbReference type="OMA" id="MRMMSVC"/>
    <dbReference type="OrthoDB" id="5860513at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000923">
        <property type="term" value="C:equatorial microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000931">
        <property type="term" value="C:gamma-tubulin ring complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008275">
        <property type="term" value="C:gamma-tubulin small complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061496">
        <property type="term" value="C:half bridge of mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061497">
        <property type="term" value="C:inner plaque of mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071957">
        <property type="term" value="C:old mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF14">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="7">
        <location>
            <begin position="181"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="6">
        <location>
            <begin position="483"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="824" mass="94911" checksum="2D10A934DBF94AB9" modified="2013-05-29" version="1">MSNTRKANALYRLVSYYVSKQPDDLQSLENFENILLICEKILDASIYTSKNYDIVIVSDAIKKKLLREDSTSDNAIKFINLFSRLLCQDILEKKAEILQFLYSICDLAYISGKAQNVKNSFSRMNFYEDSTDSESFFSALSSSFNTALTSSRPKNSTPRSLLLKTPLIASQNYDASESILLKDISFILQGISSSSVRFSTNGSATISPKLPFTIASLLSHIVELGLLYKQLSTFILFSHNIKKSTGLIKQSFFSCLDQELSAYLNLVSALEVEIRKDLLLSDDQLKMRSVTLKRIIIWTRDASMALRLMALMVENCKNLKGGQLINCILEFSSHGDPFVHEFSEKLIESLTKPFYDMLIKWIYDGELLDPFQEFFVVDKGIDTKLKLESSINIVWEGKYTLDLNMLPNFISENLAKKVFLIGKSLNFIRHGCDDDEWVQQHSKASMKDLIYGDIDFLERSIDAAYLTTSSRLIGLMSTRFSFFDHLHALKKYLLLGQGDFIAFLMESLSLTLDKPANMLYRHNLTATLESAIRESNAQFDSPDIIRRLDARMLERSHGEIGWDIFTLEYKVDSPVDVIVTPRCTRQYLKVFNFLWRLKRVEFALSNSWKKSTTGEREILRVMQGPLYKQWQKARCTNAEMIHFICQLQYYILFEVIESSWDVFYSSISKSDCTLDTLIEAHAQYTMNITHKGLLGSGKIGKEGTLLSQLHEILKIILFFKETLDHFYTYSLTEYIQRYHTTFKTKSETKDHINLKDLNSDSLNTKIIDDSGFIIEKLNNLAKEFHTHLIMLLGDLVYQSDSEMRFLGVRLNYNEYYHVPKKHIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7P8R1</accession>
    <name>M7P8R1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873442.1">
        <property type="nucleotide sequence ID" value="XM_007875251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P8R1"/>
    <dbReference type="STRING" id="1069680.M7P8R1"/>
    <dbReference type="GeneID" id="19895198"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01502"/>
    <dbReference type="eggNOG" id="ENOG502SEBV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_858215_0_0_1"/>
    <dbReference type="OMA" id="NILEAFW"/>
    <dbReference type="OrthoDB" id="429932at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030474">
        <property type="term" value="P:spindle pole body duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012578">
        <property type="entry name" value="Nucl_pore_cmplx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28003">
        <property type="entry name" value="NUCLEOPORIN POM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28003:SF1">
        <property type="entry name" value="NUCLEOPORIN POM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08058">
        <property type="entry name" value="NPCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="324" mass="37789" checksum="E2DC5C7094AEEF75" modified="2013-05-29" version="1">MSFLYEERRRKSMSNSPFSNSSFTQDLYNESPESINSLKKSRNSLNSGEIRNYESPISSEIYRYCSSDGRNISRYASETNLHSPHLFFRSKMQRKANQEPPIGFWRHPSLDIIFKRVRRVGVSEETIKRLIVNVLAIIIIQWVKNYLNKKRFIETYLKEYNSLKVYFKYFNIFIHVVLLYNVIEATLRLVRPKDTFLDLSLTPVQRKLFGLDPHVFPSSSLNNTITPPRYVKSSPQTRQSPRPSPQQVTPYNGSSQSSCPNTETKNPSKLSPFYNELSSSSPTLMNINSSSTSLSNDEFRNRTQYIPSSRYLYKRYSLNNLPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M7P968</accession>
    <name>M7P968_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873309.1">
        <property type="nucleotide sequence ID" value="XM_007875118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P968"/>
    <dbReference type="GeneID" id="19897294"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03607"/>
    <dbReference type="HOGENOM" id="CLU_2723261_0_0_1"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="72" mass="8536" checksum="B81311B730BC3662" modified="2013-05-29" version="1">MYIISKNDNEPVSDYSIALNGISYLVITYVFSIFWEIYQEYIITKILNSFNNVLSNMMVIKLFLSMNLDNYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7P9Z7</accession>
    <name>M7P9Z7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_00841</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRP40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872750.1">
        <property type="nucleotide sequence ID" value="XM_007874559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P9Z7"/>
    <dbReference type="STRING" id="1069680.M7P9Z7"/>
    <dbReference type="GeneID" id="19894539"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00841"/>
    <dbReference type="eggNOG" id="KOG1004">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069847_5_1_1"/>
    <dbReference type="OMA" id="SYMAFPN"/>
    <dbReference type="OrthoDB" id="340500at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22526">
        <property type="entry name" value="KH-I_Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05790">
        <property type="entry name" value="S1_Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000112">
        <property type="entry name" value="Exosome complex component RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049469">
        <property type="entry name" value="RRP40_KH-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037319">
        <property type="entry name" value="Rrp40_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21262">
        <property type="entry name" value="RRP40_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="K Homology" evidence="10">
        <location>
            <begin position="158"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR10690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="253" mass="28760" checksum="E976F09672064BED" modified="2013-05-29" version="1">MDKGIESLKAEERFIFPGEQVPFSDKDKTKLQIGHGLAYFYQADKLFATQTGWLKQPTKKKISINYNRGKYIPVIGDSVIGQVMIRHSEGYKVDIGSIRQAQLGILAFENATRKNRPNLQVGSLVYARVICIDNETEPEIECVNPLNGKSVYGELKGGFLVHKLSFHLCRKILEKDHPFLSILGASIPFEVAIGSNGRIWIHSENLGITITLAQAFKKCEYLNDNEMIKVCEETIREAHKWMHHNIPYEQKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAP6</accession>
    <name>M7PAP6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non-catalytic component of the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872992.1">
        <property type="nucleotide sequence ID" value="XM_007874801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PAP6"/>
    <dbReference type="STRING" id="1069680.M7PAP6"/>
    <dbReference type="GeneID" id="19894777"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01080"/>
    <dbReference type="eggNOG" id="KOG0185">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072435_0_1_1"/>
    <dbReference type="OMA" id="QPIMRRY"/>
    <dbReference type="OrthoDB" id="10248542at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03760">
        <property type="entry name" value="proteasome_beta_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016295">
        <property type="entry name" value="Proteasome_beta4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF6">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001213">
        <property type="entry name" value="Psome_endopept_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR10935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="262" mass="29624" checksum="A5BAD3ADE6BECD45" modified="2013-05-29" version="1">MLSCIPSYSKDNKKSFYFLNEQNSFNHTLKPILTGSSILGLKFKEGVMLAADNLASYGSLARYDDVERLFSFGKTVIGISGEISDFQYIKRLLHSFLIKEKNYEDGHFPCSSHIYEYLSHVFYNRRTKLNPLLNSCVVAGLDPEDVSICIPRTFCGLPEFFLGYVDFLGVAYSAPCIATGYGAYMAIPLLREATEDGRFAQLSREDARKVIDDCMRVLYCRDARSLNKFSVATVTKESVVFDTNQSVDTHWNFSEKIQGYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAU7</accession>
    <name>M7PAU7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">U3 small nucleolar RNA-associated protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00601</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872498.1">
        <property type="nucleotide sequence ID" value="XM_007874307.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7PAU7"/>
    <dbReference type="GeneID" id="19894299"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00601"/>
    <dbReference type="eggNOG" id="KOG1837">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001128_3_1_1"/>
    <dbReference type="OMA" id="NDVMWKQ"/>
    <dbReference type="OrthoDB" id="31183at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012954">
        <property type="entry name" value="BP28_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056473">
        <property type="entry name" value="HEAT_Utp10/HEAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022125">
        <property type="entry name" value="U3snoRNP10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08146">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23243">
        <property type="entry name" value="HEAT_HEATR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12397">
        <property type="entry name" value="U3snoRNP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01036">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BP28 C-terminal" evidence="9">
        <location>
            <begin position="1450"/>
            <end position="1598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1728" mass="200496" checksum="406EF8905766D994" modified="2013-05-29" version="1">MTTLAYQLQEIHENHLESLDKKKKISSLLFDPTEAADQDLDSVFSIANNGFLELLNIEPKFKRFSKTLFSEESKFIDRFTQTKQENDYLDSSIDAFLSILAPYFLLKPSIKVLEWLIRRFKIHKRNQNSLLLSIFPYHMHPFFVKILSIIDIPLPTWSFLLPFKNNRICPTHYIISKSLSDNEALFSLFMDYVQSKVKEKKDYQILLKFWATCVAETIYIMRKNSESEEKIISKILPNILEGLLSQSSEYQIACYIILVAISSNCSLSEKSLVTALTLVSRTLNKTTINAGLICLAQLAQTREGCKPLPIPVFESLLKIENINKELIIIGEKYRSDKLIVGYIHLLIENKMKNNDFSLFKELELFFSRIHFSKDEFKAIIHSLFLQIIHSEDLPVEARNHISNIIKKFKEDILFRPILEDITKIFKNDITGIQNILQITIESSPPSVSKDIIVEHTNIIEEKSAETEEFPHLINNIQNIISKNLIFMDSNQQLFYKAFYIACKHPEGINILFSNPIFQDTSSKLYFLSQIWISQNLDDINIKNSIITALEQCQIILLNEKENIDYQFFIPYLLISLNSESLEIREATSKVIPLLVEKMEMFSEKDSIIYGFNNIYGKKSSKLSWLSKRDEKRFLKEILIPNIQECIIDKNYISKILAEVFETNDKKEDISFSRSILKFICSHIISCPLQDVWFRLLQIINNSTEKNILKTKVLLPKLKYYQNMKMETRNKSLIIKELCKIVVEGENGLGIKLLLEIAKSDHTEFVIGACERLSELWNSIEHSIMFDICKVFIDQSQNRNNSTSLIITKTLNDIEIPEEVFISLFSSLNLKDLLSSLLTKYQKDRDSQNKEIEKELQYITIFLELLEKNSPETKQQLITPLFTSLNFLITLETNTRISMAYPEQIILTCLQKIISNTSINFDSKTIRMDLLINCVCSSPTPHVHNRALLLITTIAKTVPELILHNIMPIFTFMGTNILHQDNYFSEYIIEQTIQKVIPPLISNNRDKKADIIVNSSTILTSFVNAFSHIPDHRKLKLFNILIKTLGPKDFLYAFLVLLLNMKYNLEEKGKNTEARVISNFCLSLSTSFDIEIQLLSFWKLLDFAKSLTINTLDIPDDSILIDTSEFDNDKLNSLRSQLIKIVGNIFASKQFKTTFLTIHKTISDDSNIYSNIYKIIKILIEMKEISTVYKTLEDSLQYVLKETLILLPIKSFTITIKKMLISKNLRLRLNACVILKDKVETESLENTDTELAAIDLLPDIIENTFKKGPELTYSALICINVIAKRYGKNNPAKFFQILENIIEVGLKNENKDLQILSCVSITILSVYLGPRLVPKLPSFVPYILEKLKESHDNIFEITVCSLMEALINSIPSFMLSYTKLMLEACLYKNPTENRELIKVKNSLNNAIANNFPLKKIFLSISQSWKYIITLDKTTILFSLDLLEITIKNSKKEEIERISLKLFNFFLEVFNMKQDDQLDTKIIIFIKEKAIEVFIQVIMKLNDTTFRPLFLNFRQWAFEDFYKENIRIDPKPRLLIFYKFLGVFLGRFKSIVTNYFSHIFDDTIKLLEKEKDETFSLNSDLWEAIINSIYQSLLHDTEEFWQNSIRFSKIAPALISYLSFTPRYKIEKYLIPSIVQLASVTISDEHYKTINTLILNHMSSDNTAVRLAVLETQKELYTKLKEEWLTTLPQTIPFISEALEDENEKIEYFTQKLIITIESYLGESLQRFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7PBD0</accession>
    <name>M7PBD0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial distribution and morphology protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Mitochondrial inheritance component MDM12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MDM12</name>
        <name evidence="12" type="ORF">PNEG_00787</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion outer membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="9">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the MDM12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872691.1">
        <property type="nucleotide sequence ID" value="XM_007874500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PBD0"/>
    <dbReference type="STRING" id="1069680.M7PBD0"/>
    <dbReference type="GeneID" id="19894485"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00787"/>
    <dbReference type="eggNOG" id="ENOG502S3PB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026794_2_0_1"/>
    <dbReference type="OrthoDB" id="3356905at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21672">
        <property type="entry name" value="SMP_Mdm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03104">
        <property type="entry name" value="Mdm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027532">
        <property type="entry name" value="Mdm12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28204">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28204:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26544">
        <property type="entry name" value="Mdm12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="1"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR11195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="359" mass="41363" checksum="9FECF1ABB848DEB8" modified="2013-05-29" version="1">MEFDWSKLDEEFALKMKNFLNQQFEKIFLPSYLRNINVESFDFGSIAPVVDIENIEDPYPHFYQDTDTNHNELGEEIVKHCQDLKEDEKDEQDTDFSIDNSDVASTTSQPPPYAEAGFSQFQMHDLTNLLTHNFPITSYKSLKSNIGTNCLPFFQSTFSGSSGNIVSVSGLSTPHWVGTHLLNSHYQLPCKNEEILPPINQNIQITSSSNLLPVMTQTKNNLIEVKNNKGSQNTNFNEDFQIRFRIAYEGDIRIEITAELHLNYHSTMFITLPVKITLTGLSFEAIAILAYINKRFHFCFIDEEQKEKLLKNIKIESEIGDKSKQILKNVGKIETFLLEQFRKIIERELVFPSWLTIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7PBL3</accession>
    <name>M7PBL3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein import receptor MAS20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_00286</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Tom20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872157.1">
        <property type="nucleotide sequence ID" value="XM_007873966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PBL3"/>
    <dbReference type="STRING" id="1069680.M7PBL3"/>
    <dbReference type="GeneID" id="19893984"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00286"/>
    <dbReference type="eggNOG" id="KOG4056">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090411_2_0_1"/>
    <dbReference type="OMA" id="DMIAYDG"/>
    <dbReference type="OrthoDB" id="2154253at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016031">
        <property type="term" value="P:tRNA import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.10">
        <property type="entry name" value="Mitochondrial outer membrane translocase complex, subunit Tom20 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002056">
        <property type="entry name" value="MAS20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023392">
        <property type="entry name" value="Tom20_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430:SF0">
        <property type="entry name" value="TRANSLOCASE OF OUTER MITOCHONDRIAL MEMBRANE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02064">
        <property type="entry name" value="MAS20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037707">
        <property type="entry name" value="MAS20_rcpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00351">
        <property type="entry name" value="OM20RECEPTOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47157">
        <property type="entry name" value="Mitochondrial import receptor subunit Tom20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR11255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="18851" checksum="EC9BD2710D0BEE64" modified="2013-05-29" version="1">MKTSWIIGIALSSALAFGIGYAIHFDYKRRNDAAFRRKLRRDKKKLSRAQKAESQHQEEVLAQAIRKAYHEVQKCTLPHLVEEREQFFMQEVAKGEGLYSQGSHKFIEAASCFFRALKVYPNQMELMVIYEKTIPKEVNAIIVKLLQLDESTNASKNIEETLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCQ8</accession>
    <name>M7PCQ8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Thioredoxin reductase</fullName>
            <ecNumber evidence="3 13">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PNEG_00130</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="14">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="3 13"/>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871990.1">
        <property type="nucleotide sequence ID" value="XM_007873799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCQ8"/>
    <dbReference type="STRING" id="1069680.M7PCQ8"/>
    <dbReference type="GeneID" id="19893828"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00130"/>
    <dbReference type="eggNOG" id="KOG0404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031864_5_1_1"/>
    <dbReference type="OMA" id="GPCHVLK"/>
    <dbReference type="OrthoDB" id="371245at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000064">
        <property type="entry name" value="Thioredoxin reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 13" id="KW-0274">FAD</keyword>
    <keyword evidence="6 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 14" id="KW-0521">NADP</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="15">
        <location>
            <begin position="4"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMR11695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="325" mass="35404" checksum="73274D9CB55D4B81" modified="2013-05-29" version="1">MHSKVVIIGSGPSGHTAAIYLGRAELKPVLYEGMLANGIAPGGQLTTTTDVENYPGFPDGILGPSLMEAFRKQSEKYGAQIITDTVSRLDLSERPFKYWCESDENVCHTADVIILATGAYARRLHIPGEQIYWQRGISACAICDGAAPIFREKPLAVVGGGDSAAEESLFLTRYAAKIYLLVRRDKLRASPIMAKRLLNHSKIEILWNTVALESLGDNNLMNSLKIKNLKTQEVSELQVNGLFYAIGHEPATTLVRGQVECDKDGYIITKNGGPETNVKGFFAAGDVQDKIWRQAVTSAGSGCMAGLAAERLLAEEEEMKNIKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M7PD21</accession>
    <name>M7PD21_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872070.1">
        <property type="nucleotide sequence ID" value="XM_007873879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PD21"/>
    <dbReference type="STRING" id="1069680.M7PD21"/>
    <dbReference type="GeneID" id="19893900"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00202"/>
    <dbReference type="HOGENOM" id="CLU_047273_2_0_1"/>
    <dbReference type="OrthoDB" id="20109at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013241">
        <property type="entry name" value="RNase_P_Pop3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28272">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28272:SF1">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08228">
        <property type="entry name" value="RNase_P_pop3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="286" mass="32756" checksum="71C7E90572F2D1D2" modified="2013-05-29" version="1">MKSKKKKESKDLFAQRNTSGGVRKKAKKQCVSSTFYLNNPYIIQWPKISEEDQEVILSNILNIFSFFPNQRKKNKILEKKRDLNNNKSTNYIDGDKECIDESMDDNISSSQTDKREFITKYMTLGINETTKLLEMYSKIGIPLSAPSYLRFFDKIDENYLSLLKNNKSANILKVVVICKEDIQHNILYSYFPVLCGVVNEVFSKIEASDDNSQSGIRLVTLPKGSEQQLSEAAGLKRLAAIGIMKNTPHAEKIIDYIFKKIPPPQIPWLRHPSIFYPTSIIQASNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>M7PD62</accession>
    <name>M7PD62_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00245</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872115.1">
        <property type="nucleotide sequence ID" value="XM_007873924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PD62"/>
    <dbReference type="STRING" id="1069680.M7PD62"/>
    <dbReference type="GeneID" id="19893943"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00245"/>
    <dbReference type="eggNOG" id="KOG0739">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_21_2_1"/>
    <dbReference type="OMA" id="IEWTNEF"/>
    <dbReference type="OrthoDB" id="29072at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007084">
        <property type="term" value="P:mitotic nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19521">
        <property type="entry name" value="RecA-like_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000043">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000015">
        <property type="entry name" value="vacuolar protein sorting-associated protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="129"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="399" mass="44567" checksum="6BCB1FD164B6D3A6" modified="2013-05-29" version="1">MALKYEKSENGKNLIKDKVIQYLDRAEALKAYLQKNNENKKHSLVKSGGNELSLGKKCYKRKDGDSDYDDDDDIDTRKLKNALANTVISESPNVKWDDVAGLDNAKETLKEAVILPMKLPHLFKGNRKPWVGILLYGPPGTGKSYLAKAVATEAKSTFFSVSSSDIISKWMGESERLVKQLFVMAREMRPSIIFIDEIDALAGIRNEGDSEASRRIKTELLVQMNGVGTDSTGILVLGASNIPWTLDPAIRRRFERRVYVPLPDATARLKLFKLNIGDVPTELTANDYKVLVDKTNGYSGSDIAIVVRDAIMEPVRRIYTATHFCYVNCPDGKRLLTPCSPGVSGAQEMTWENGTVDTLLEPMLTMNDFLKALRNTRPTVNSDDLKRYVEFTNEFGLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7PDH6</accession>
    <name>M7PDH6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquinol-cytochrome C reductase hinge domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_02997</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRH/QCR6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875046.1">
        <property type="nucleotide sequence ID" value="XM_007876855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PDH6"/>
    <dbReference type="STRING" id="1069680.M7PDH6"/>
    <dbReference type="GeneID" id="19896684"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02997"/>
    <dbReference type="HOGENOM" id="CLU_2211081_0_0_1"/>
    <dbReference type="OrthoDB" id="405848at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.20">
        <property type="entry name" value="Ubiquinol-cytochrome C reductase hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023184">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036811">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02320">
        <property type="entry name" value="UCR_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81531">
        <property type="entry name" value="Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082826" description="Ubiquinol-cytochrome C reductase hinge domain-containing protein" evidence="10">
        <location>
            <begin position="24"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquinol-cytochrome C reductase hinge" evidence="11">
        <location>
            <begin position="54"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR08514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="107" mass="12868" checksum="FA9543DB58157FA3" modified="2013-05-29" version="1">MEGISRLRLWISDIVFFPLFVSAEERNYDEKDNLNEKKREKNDDYDNNDMDPEDIMPQIQEECSNTKKCAPLKHHYDECKERVSSAFNESERKKLDNENCVEEMFHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7PDJ4</accession>
    <name>M7PDJ4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DASH complex subunit DAD3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Outer kinetochore protein DAD3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PNEG_03015</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875066.1">
        <property type="nucleotide sequence ID" value="XM_007876875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PDJ4"/>
    <dbReference type="STRING" id="1069680.M7PDJ4"/>
    <dbReference type="GeneID" id="19896702"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03015"/>
    <dbReference type="eggNOG" id="ENOG502SCNH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118180_1_0_1"/>
    <dbReference type="OMA" id="MEHASAH"/>
    <dbReference type="OrthoDB" id="2443965at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013965">
        <property type="entry name" value="DASH_Dad3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08656">
        <property type="entry name" value="DASH_Dad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMR08534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="89" mass="9749" checksum="0D31FC395A94B073" modified="2013-05-29" version="1">MEKTVQGISRLTIDSFSSLEIALLQEYSKLAQNLNKLSNILHVLAHTPMSHVLDSLSILERKTGLVFTLFKASVWAILANAGQADILNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M7PDT3</accession>
    <name>M7PDT3_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_03105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875161.1">
        <property type="nucleotide sequence ID" value="XM_007876970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PDT3"/>
    <dbReference type="STRING" id="1069680.M7PDT3"/>
    <dbReference type="GeneID" id="19896792"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03105"/>
    <dbReference type="eggNOG" id="ENOG502R7F2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_966824_0_0_1"/>
    <dbReference type="OMA" id="QMANTRR"/>
    <dbReference type="OrthoDB" id="5353585at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23703">
        <property type="entry name" value="mS26_PET12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058940">
        <property type="entry name" value="mS26_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26163">
        <property type="entry name" value="mS26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="288" mass="33863" checksum="F7B6ABA0AFCB0089" modified="2013-05-29" version="1">MINNKNYIFLFFVSKRLNFVLKRCFFCSTNIKSSISRNKIRNTSPGSHNYVPGVKGYAPDIYPPRKISFECKKKPKYPDLHKTVAEPRLKNETNTWRSKMKELRRRYLTEYVMEQKKKDLEKMQEKEKINEMIKAEKLTLCSEKHHRYSIPTIKSLIEDEYPIADSNKLERMKQKRNNYEITKDKDKIERLRHFLTLYSHSENFISSMEELDDAVNKSFQEIPTGSPPSYSIQFLYDKKENSFLNSKDSVHPEIFDALLGTVDGGKLGPDELIKLSKIQNGEKSNIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7PE31</accession>
    <name>M7PE31_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874944.1">
        <property type="nucleotide sequence ID" value="XM_007876753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PE31"/>
    <dbReference type="STRING" id="1069680.M7PE31"/>
    <dbReference type="GeneID" id="19896591"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02904"/>
    <dbReference type="eggNOG" id="KOG1299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013933_3_1_1"/>
    <dbReference type="OMA" id="VHQLNNA"/>
    <dbReference type="OrthoDB" id="10266265at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="575" mass="66532" checksum="7C5983FA31F296DD" modified="2013-05-29" version="1">MNVIQVIQNYIETIASLSKGMKIMLLDASTTPMMSMATTKSFLLSREIYLIEKVLRCIYGRILTNDSRLENSKRENVRHLTCICVIKPCFESVQHLSEELRSPKYGRYFVYFTNILNKNYLEILAASDDHEVVQSLQEIFADYLAVHSDLAALYLPISTHNLWNKRWDTWDSIALQKSRDGLLSILLSLKKKPIIRYERNSNMAKVLGNEVKKMMEEEEQLFNFYRMDAAPILLILDRCNDPVTPLLTQWTYEAMVHELVGIEHGRVDISNMIYEKKLKEIILSPEQDAFFKENMYLNFGDLGTRIKEYVDHYHSKTKSNIEIQNVSDMKRFIEEYPEFRQLSGNVSKHVILMSELSTRVNKESLLEVSELEQSLACNDSHSTDLKNLQKLIQSPISNNNKIRLVLLYALRYEKNKNNTLSSLILSLAQAGVTPKELSIINTLLEYAGSSKRLDNLYELESIFSRARSGFKGLNDVENVYTQHRPRLQNILTSLIKGRLREQTHPCIEESTTLKEKPQDIIVYMVGGTTYTEARIVHEINLYIPGVRIILASDHIHNSKSFLQQLKRFNTTKINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7PEB1</accession>
    <name>M7PEB1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lethal giant larvae (Lgl)-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02959</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat L(2)GL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875004.1">
        <property type="nucleotide sequence ID" value="XM_007876813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PEB1"/>
    <dbReference type="STRING" id="1069680.M7PEB1"/>
    <dbReference type="GeneID" id="19896646"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02959"/>
    <dbReference type="eggNOG" id="KOG1983">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006030_0_0_1"/>
    <dbReference type="OMA" id="QIYVFGQ"/>
    <dbReference type="OrthoDB" id="19944at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013905">
        <property type="entry name" value="Lgl_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF25">
        <property type="entry name" value="TOMOSYN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08596">
        <property type="entry name" value="Lgl_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lethal giant larvae (Lgl)-like C-terminal" evidence="3">
        <location>
            <begin position="531"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1025" mass="116126" checksum="18CAC59875F250F9" modified="2013-05-29" version="1">MSFFAKDKRISHKNTQEPTKYGEAFLCDELSSYGVSSGIRLATFDAIQSLLAIATFDSKIYIFKERNVKVQYSLPKHLLIRQLLLHNNFLIAIDSINNIYSWSLDKASTMPTAVHSIRGAVTCVGTDPSIDWLFIGLKDGTIDVWDIDRESIAPYKIGNLYSERYEKLRQKNCNYVPSKSYVSPIISIQIHPKDLGMILIGYSDGAVLYSIKKNVPINFFELEIPQKMPETGSSGKVVISRPKLTSLSWAPHGSHFLTSHQNGCFAFWSTKSDKHPLHVRTLDDVGIDISLGEKTQSDTSQIAYTRSPIFFILWNCNDDLENTTVFIVGGNLNNKDSKELNILKFGQSPSMSSSTTVFSDYYSKPKQHLALSHFLSSNVVNICIFPKISPLYLGNYNTEMIMLILASGEIELLSYPDGIFLNSLKSLPASLEWLSPKIRDISLSFVSKNTSSFGYRKYIEGSDDLYQGKGSMHHKLFYHNEIISSGHDNGIIRLYNVTQDYKFQKIHEIFLAKVLNLSPNMIKVVITKFSEMSDLIIGCEGGELIVYKLFSPDKKAFEFDDSFVSSVFNRSSKQNDNKDLKSDSYMSNKNNVLSNNNRNQNNLSAVSIFQIHRGSVISLKTSNIGLIACGYEFGTTILINTFTRNIILQIELSEIKAEKKKSKTFKDAEDSEDFELEVAVVFEFTTGKFKKNDSTVLFIVGTSFGRLIFYNLFLTSENKFNIEYMGEFLFEGGSIINIISIFKDTMRPYILYPSIFDNLKNNSVSESYLIIVAENSVKVLDSCFFKISEYFMEKNVKCVSANIVYHESINVAVACLINNKKVLFLSFPNLNYIFSVNLPHLFIDKLNKSIITILGDIYLWINEMELSLFNLFGNGIRITEFPSGVLYDNSKKVPPRPTISTWEWITGTKYITIAELDSLIGGPDRPLPKKLLQSLAEQELKNKTEKKILSAGQRNEPTDSYGNIFVQTTENIRERGRKIFGVGEKLEFLEESSINMLKSIQDYANTQKKAISKQAFKTSVKTFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M7PEN2</accession>
    <name>M7PEN2_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_02705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874730.1">
        <property type="nucleotide sequence ID" value="XM_007876539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PEN2"/>
    <dbReference type="STRING" id="1069680.M7PEN2"/>
    <dbReference type="GeneID" id="19896396"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02705"/>
    <dbReference type="HOGENOM" id="CLU_1759590_0_0_1"/>
    <dbReference type="OrthoDB" id="5366485at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056539">
        <property type="entry name" value="NuiA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42093">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42093:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23151">
        <property type="entry name" value="NuiA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="148" mass="17322" checksum="68AF78CBC7154A4A" modified="2013-05-29" version="1">MEDSYLTFLKKNTIFSKPDKSLSLKFPSDILPDDLFSFTTCKLKQYCYSSEADEPFNVVFYNSKEEKCHKTLLSEKLKIPEGEIVQEKPEEWDPYGDYIDIIEIVKEISKTNEINVYKWKRMANEYIWILGWKNGEGLIGVHTVGIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7PFC1</accession>
    <name>M7PFC1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[acyl-carrier-protein] S-malonyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02499</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FabD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874509.1">
        <property type="nucleotide sequence ID" value="XM_007876318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PFC1"/>
    <dbReference type="STRING" id="1069680.M7PFC1"/>
    <dbReference type="GeneID" id="19896191"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02499"/>
    <dbReference type="eggNOG" id="KOG2926">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030558_5_0_1"/>
    <dbReference type="OMA" id="AANYNCP"/>
    <dbReference type="OrthoDB" id="541883at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.250">
        <property type="entry name" value="Malonyl-CoA ACP transacylase, ACP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050858">
        <property type="entry name" value="Mal-CoA-ACP_Trans/PKS_FabD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024925">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42681">
        <property type="entry name" value="MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42681:SF1">
        <property type="entry name" value="MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000446">
        <property type="entry name" value="Mct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="6">
        <location>
            <begin position="6"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="335" mass="38353" checksum="4206A14D33E48182" modified="2013-05-29" version="1">MSRILLFPGMFFIWQGTQYIGMARPWIEAFCEARHFFNEVDEVLGFSLQKVMNYGPSKVLDQSENAQPAILATSYCIIEILRKHFGIELKDYFTYTMGHSLGEYTSLLFAGVFSLPTAIRLVRERGEWMKSIACHETQVIAVMQKRFILDTLIQQLKIFQEELPAGQIIGLANDNTNTQIVLSGTKQTLNTFLTRFSLRNRCILRTIPLRVSVPVHSSFMNPVSNNLMDKLDTLSLFPPSITVISNVTAQPYPTDLFLLKKLLARQTKETVQWFQSTQYVLKHVAPIQWVAMGPKHVIFHMLTSQISEHYLFKLASVKDIFPLLNSLEKNIILNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7PFZ0</accession>
    <name>M7PFZ0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear segregation protein Bfr1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874324.1">
        <property type="nucleotide sequence ID" value="XM_007876133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PFZ0"/>
    <dbReference type="STRING" id="1069680.M7PFZ0"/>
    <dbReference type="GeneID" id="19896016"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02323"/>
    <dbReference type="eggNOG" id="ENOG502QRKP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023943_1_0_1"/>
    <dbReference type="OMA" id="AHWKEDQ"/>
    <dbReference type="OrthoDB" id="2195113at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039604">
        <property type="entry name" value="Bfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027:SF2">
        <property type="entry name" value="LEBERCILIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027">
        <property type="entry name" value="NUCLEAR SEGREGATION PROTEIN BFR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="440"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="182"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="55139" checksum="561925923BC8FC14" modified="2013-05-29" version="1">MQQAVKVTFKRPVKPDEEAFKKSLSQIDQELKQMTEKIENIRVKEVRFRDIGGVKVRSKDIRHQLDEIREKQARLKLSKQKTVDQVKQMEEAMKNKINEVQAMKKKLPFKSVDELDRHISELEKAVDLGMLKLVDEKKYLSEISMLKRLRKSFMDLVFQQLSIDSDKKRIVEIKSTLEDPVSKALSEQYDKLKAEQNSLRQEQDNVYKSQKSLYEEKNLLSQRKNEIYERRKKLQDEYYSSLRKYQEYEREEKQKAWEKRKLQQDEYNREKRKQIADRILEEASMPAFLEEIYTCENLVRFLDPSAAISETHSLENSNLPQLNIRTVLETDENFGTVLKSKAEREDYFICCNEKKSKTNKRNKRPSSAYVNGTGNFNIDMNILQQFSFVNVTPPFNHSEIPSCIENLKQRMVWYKENQEKTVAERIEKAKKEIEELEAKALQQNQEKKHVQKKTNDISKKETADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M7PGP0</accession>
    <name>M7PGP0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="12">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PNEG_02208</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="12"/>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874191.1">
        <property type="nucleotide sequence ID" value="XM_007876000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PGP0"/>
    <dbReference type="STRING" id="1069680.M7PGP0"/>
    <dbReference type="GeneID" id="19895901"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02208"/>
    <dbReference type="eggNOG" id="KOG0343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_26_1_1"/>
    <dbReference type="OMA" id="YDKMFER"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17941">
        <property type="entry name" value="DEADc_DDX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="69"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="269"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="659"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="660"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="677"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMR09624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="741" mass="86155" checksum="5E13189CA87E9578" modified="2013-05-29" version="1">MPIKKSKKLREILREKYLKELEDLEKRINEFDSSKNIRLFSELPLSKQTAEGLKENHYFKLTTIQKRAIPIALSGRDILGASRTGSGKTIAFLVPVLENLFRRKWGVYDGLGALIISPTRELATQIFKVLCKIGRKHSFSAGLAIGGKDLQEEAQRISRMNIMVCTPGRILQHMDQTSGFDVDKLQMLVLDEADRILDMGFQKTIDSIIENLPKNRQTLLFSATQTKSVKDLSRISLKNPDYIAVHEKENSSTPPTLLQYYSIIPLDEKINILFSFIKTHLKSKTLVFMSTIKQVRFIYETFKHLQPGVPLLHLYGRKKQHSRNLITTQFFTAKHAVMFCTDIVARGLDFPMVDWVLQFDCPEDADTYIHRVGRTARYDKSGKALIFLCPSEIKILERLKQKKVQMQEIKIRNSKKINISKQLQHICFKDPEIKYLGQRALISYLKSIYLQKDKEVFKFEDLSIEEFSSKMGLLGVPKIKFLQSLNSKILKNKPRELQKYSNDKNMQKNDEIDKKETIKTKYDKMFKRTNQNVISEHYRKMIEEDNDLLVSHNSTDNDDFIKVKKVDNNFNEEPLENCFIALSKRKQKIALSKKAMLKYRPKGTKLIYDDQGNVSNIYKFQDETSFHKAGTADDQKKKYLQEEEKKMIQNDIVDKIQTKEKRHQKRKKTSAIERKNITQNSTDNNTDFESSSNDNHSLIQAKRQKIYLDKNNSKDSSIIEIEHLDTLQDHENLALKLLNSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M7PGW1</accession>
    <name>M7PGW1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">INO80 complex subunit 3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873860.1">
        <property type="nucleotide sequence ID" value="XM_007875669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PGW1"/>
    <dbReference type="STRING" id="1069680.M7PGW1"/>
    <dbReference type="GeneID" id="19895580"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01886"/>
    <dbReference type="HOGENOM" id="CLU_1787633_0_0_1"/>
    <dbReference type="OrthoDB" id="285793at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032742">
        <property type="entry name" value="Iec3_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14612">
        <property type="entry name" value="Ino80_Iec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit 3 N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="145" mass="16672" checksum="A05891049EC96570" modified="2013-05-29" version="1">MPKSFKRKYIKLCENYDSLIEKSEDLQLQIEKAKVIANRISSENTHLMDLLLDQENAYINSSISSELESAEESNTETDSLKNHNSESDISSYYRNGTPPHLLSLSPHWDYSPVEIIEEEKDDQSRSILSTNSLLLYGKKEKKNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7PH15</accession>
    <name>M7PH15_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873905.1">
        <property type="nucleotide sequence ID" value="XM_007875714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PH15"/>
    <dbReference type="STRING" id="1069680.M7PH15"/>
    <dbReference type="GeneID" id="19895623"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01929"/>
    <dbReference type="eggNOG" id="ENOG502QX1K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008906_1_0_1"/>
    <dbReference type="OMA" id="DWGEGSL"/>
    <dbReference type="OrthoDB" id="19159at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990334">
        <property type="term" value="C:Bfa1-Bub2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001100">
        <property type="term" value="P:negative regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034586">
        <property type="entry name" value="Bfa1/Byr4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35140">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BFA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35140:SF1">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BFA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="784" mass="89383" checksum="EAD98BD778FE6C08" modified="2013-05-29" version="1">MNKEVEIWDDEDLLGEICDISDQVSDASLIRDHIKDVPFEKEMMVKDINEVMEKAAMSGIPLPRNITPSSLMGGTIRRLGTRKAGVTVMDDWGDDIQLTPGLLNEKLIQRSSAVENEDVFGDIEDWSAKIEKPQTAVQKRLREGLLPRKSVEPSIIAQNSTFDDTFESDFDIPNNIDNFHIHHPPQKTHALGISHAPTLESDNDDWGDSSLGIRSAGADSRSARASIASSLSPSMSSMTLSEDESILEGIELPSSALDLQKRFDICRQRKINERTLKEVQFLKEDFFVDIEVDKDNFLDSSKKFNSNVNIIKHFMDNDTQNPQRQPQATIKFSSKSSRIPQPVLPLPKINKENISRPSYSENRPLVQEKMVSKKSSLMNFQEQEDNLHSMSTKRSMPSLQSQYISPPHYNLSDNSRLKSNTYNTHHNHPKTVLENGHSKTHSNNFNSSNPRYSRGSDEFPGIVSRVPRYASPTNASLARGTTLLNKFQKCTSDGISRDHSPIRILTRPQKLSNYGDGTELDAFDDLPTCFATENKYSEKNYKKEHLKFKDASDIPLETHYSKIPEMDRYKDGSSKSNIHPMIKNNGFRPKTNIQLFPTKIKLKKKTKQMPTLIRNLNSSPIPKVVGQMKYNPQTRIWEGNEVELQKFDLYYTSPRPALISHISDKKDMQIVGDMMFDPQKMCWIKINPSTEDENDPFEGIKDLANNDSYIFFESSNNSNGLSNSNYTDTQNFVVGEEFDVGPGFIRKQREEEENWKKSIQGWIKQGFPNRNHLREIRKIVINGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7PH97</accession>
    <name>M7PH97_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor IIF subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_01995</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TFIIF alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873975.1">
        <property type="nucleotide sequence ID" value="XM_007875784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PH97"/>
    <dbReference type="STRING" id="1069680.M7PH97"/>
    <dbReference type="GeneID" id="19895689"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01995"/>
    <dbReference type="eggNOG" id="KOG2393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020322_0_0_1"/>
    <dbReference type="OMA" id="WCPESER"/>
    <dbReference type="OrthoDB" id="76676at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001096">
        <property type="term" value="F:TFIIF-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008851">
        <property type="entry name" value="TFIIF-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011">
        <property type="entry name" value="TFIIF-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05793">
        <property type="entry name" value="TFIIF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="443"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="466"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="507"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR09814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="580" mass="67518" checksum="408E5847A0B318D3" modified="2013-05-29" version="1">MLEDEKIHVNQESHHNIDSLETPAYMDFKLTSVAKSIEGTKHHILKFHSTRMIDPLTDFTPPVRLHRKDPMSTVGIQESMSETGSKNNSQETVSSGTTQSTKTNIFKKKTRQGYRINKAEWILRQEERVPWVLEDFDGRNTWIGTMEGGQSHNYVFFVFAENGFKVVPANKYYRFNQKSRYQTLSIDEAEAKMNKRIIVPRWFMKKEIKENNHEEYPSGPIYRLRTVASQRKSELNGDRDGYEELDFNEEFADDEETPFIEGNEEDNRELEERIKREMRSANLLEDENKYMSENSYDEKRRMDKEGRKMRKYLTYHEKNHIYETDEENNPYVSEDDTDSDTSNFQRGNLVKQEKIIKDKKKQQLQDNAIQSDFNTNKNFSIVSKALSTEVSNSLSNDFTKHLALSSALKTQKQDYFHSIGPTRPYLITLKLPKQHLISYANSFQSSLSSPRETSPERNKRRKLDSDVNNLEDSSNLSSSDSTRKIKIRTINNLQDHNLNSPLSPNSGSDTHNTAESTSNDSYLVTEEELKNAIQSRKMNAKELLKSFKPQLEMNSKNRDLILELVTRIAKMENGYLVLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7PHB1</accession>
    <name>M7PHB1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoplasmic reticulum junction formation protein lunapark</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in determining ER morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lunapark family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873995.1">
        <property type="nucleotide sequence ID" value="XM_007875804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PHB1"/>
    <dbReference type="STRING" id="1069680.M7PHB1"/>
    <dbReference type="GeneID" id="19895709"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02015"/>
    <dbReference type="eggNOG" id="KOG2846">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043850_1_0_1"/>
    <dbReference type="OMA" id="CGYFNPS"/>
    <dbReference type="OrthoDB" id="1725934at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098826">
        <property type="term" value="C:endoplasmic reticulum tubular network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071788">
        <property type="term" value="P:endoplasmic reticulum tubular network maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903373">
        <property type="term" value="P:positive regulation of endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040115">
        <property type="entry name" value="Lnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019273">
        <property type="entry name" value="Lunapark_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166:SF12">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10058">
        <property type="entry name" value="Zn_ribbon_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Lunapark zinc ribbon" evidence="2">
        <location>
            <begin position="239"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="348" mass="40606" checksum="D13D0CB97F20422C" modified="2013-05-29" version="1">MKHIWNWFKKDSSTNSYERILSQLALEINHHESRLSTFRLRSVRVKRLFTLYCTILYLIYFLIWILFYMRNTEDIEKWFLRLSILIISLFCIYFGRVIFTIYYTKMISSEESSLELLRTKQYEKVEELKAKTNFYSTQLLIDRYSGSQRNTPEKPAVSLLDLNDSGKKTPKHSFSSSSVDFLQPTFQHSNQQNQTSNLRLRHTNNSNTDNSIHESFFTTSDTPFPTDSYVKLSQDNSFISRILNFIIGPDETSPENRYALICKKCGTHNGLAPYGEKWESIKYICMNCGIWNGNIKQNAKDTKNTEDPLSISNSIPNPNETVENQEEIGLKTSKPDKVKLLKQTIKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7PHB9</accession>
    <name>M7PHB9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferroxidase</fullName>
            <ecNumber evidence="3">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_02025</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the frataxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874005.1">
        <property type="nucleotide sequence ID" value="XM_007875814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PHB9"/>
    <dbReference type="STRING" id="1069680.M7PHB9"/>
    <dbReference type="GeneID" id="19895719"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02025"/>
    <dbReference type="eggNOG" id="KOG3413">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1434982_0_0_1"/>
    <dbReference type="OrthoDB" id="1897642at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034986">
        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017789">
        <property type="entry name" value="Frataxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020895">
        <property type="entry name" value="Frataxin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03421">
        <property type="entry name" value="FeS_CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03422">
        <property type="entry name" value="mito_frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="FRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821:SF2">
        <property type="entry name" value="FRATAXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01344">
        <property type="entry name" value="FRATAXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0409">Iron storage</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR09844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="189" mass="22448" checksum="17CE8535EE772444" modified="2013-05-29" version="1">MKNYGTLFSIGSAGFLKRKSQFEYRFIHNIIFQNLHLIKFNYLKYNLQNVVLLKKNSNKLVNRILFVFFRKYSSDLTIRKYHQLADNTIERILYALEQMQQDYPEKTIEVEYSQGVLTLDLGHYGTYVLNKQPPNRQIWVSSPISGPKRYDWIPSNDEKDGKWIYLRDNGILEDMLKSELKKIIGDLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7PHK9</accession>
    <name>M7PHK9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01702</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873666.1">
        <property type="nucleotide sequence ID" value="XM_007875475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PHK9"/>
    <dbReference type="STRING" id="1069680.M7PHK9"/>
    <dbReference type="GeneID" id="19895396"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01702"/>
    <dbReference type="eggNOG" id="KOG0281">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_103_6_1"/>
    <dbReference type="OMA" id="PSRGVYC"/>
    <dbReference type="OrthoDB" id="19711at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF745">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="150"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="190"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="232"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="278"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="318"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="358"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="439" mass="51278" checksum="07F63CCD6E003A39" modified="2013-05-29" version="1">MDLIQRLPLELILKIFSYLSHGEVVICMIVCKGWYSLATHPLLWKQLYVQKEWGMNEEYIQRCEEWARRKIGVLNKWMNNFSKIKAFEHEKTKRDNNLFRPVHITLLPGMEVILNWKFVYSQRYLLVKNWEKGKYVCYTIPRGQVMVKQSEIHQDRIYCIQFDRNFIVSGSKDKTIRIWDMQKGICRKILRGHQGSVLALQFDVNMNLLVSGSSDRFVIIWNLSSGKIRSIYKGHTGSVLGLCFDAKHIVTCSKDLTVRIWSHVYHEVRDKRHHLRILRGHRAAVNAVQLKNDQIVSASGDRTIKIWDLYTGSCLHTIMEHQRGIACLQFDGHRIVSGSSDRLIRLFDANSGQILRTFEGHMDLVRALCHDSHKIISGSYDQTIRIWDICSGKLLHNIESKDSGHIYRIVFDDVRIMSCGQKKQIMVYDFGKDIDTTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7PIU2</accession>
    <name>M7PIU2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01621</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873578.1">
        <property type="nucleotide sequence ID" value="XM_007875387.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PIU2"/>
    <dbReference type="STRING" id="1069680.M7PIU2"/>
    <dbReference type="GeneID" id="19895315"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01621"/>
    <dbReference type="eggNOG" id="KOG0878">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071479_4_0_1"/>
    <dbReference type="OMA" id="HPSGYEE"/>
    <dbReference type="OrthoDB" id="268693at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="15442" checksum="8B6C5FF6ED53D12A" modified="2013-05-29" version="1">MVSSKTRLVIVKKRRKRFTRHQSDKYKCISPSWRKPKGIDNRVRRRFKGQIPMPNIGYGSDKRTRYMRPNGYYTFLIRNESDVDLLLMHNDVYIGEIASNISSKKRVNIVEKARKLGVKLTNGLSRIRSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M7PIY7</accession>
    <name>M7PIY7_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873044.1">
        <property type="nucleotide sequence ID" value="XM_007874853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PIY7"/>
    <dbReference type="GeneID" id="19894826"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01129"/>
    <dbReference type="HOGENOM" id="CLU_897475_0_0_1"/>
    <dbReference type="OrthoDB" id="5274785at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="310" mass="36124" checksum="3E1F9902A69A244F" modified="2013-05-29" version="1">MCISNKWMGHKEELFSVNYGDTIAHVGCNTMLRVESKVIRLFSPGLTRYLRHITVFSNNAEYRKIHKGVHYILTLVEETEVEAFSLLMEVLHDPTTFSWKTEFHSVLRMAAKYEVSEPIVGFSLAYCMKFYKQPQADPLMLLHASFFCKDDDVFTDALLLVLKKLDLYRNSKSFKKLPCYLGFQIMSMSESLFREYTCLSDFSNNDNWPDCEIELCTEKFRYACKNLFDSFALPAVICWDGDLLSEWYNKSDEEIIESIGVWEMPFAADPEHIRQCRDNWAKALKSNAKWLNRKLKGQLHDTSISSLLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJH6</accession>
    <name>M7PJH6_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873243.1">
        <property type="nucleotide sequence ID" value="XM_007875052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJH6"/>
    <dbReference type="GeneID" id="19895014"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01317"/>
    <dbReference type="HOGENOM" id="CLU_2292883_0_0_1"/>
    <dbReference type="OrthoDB" id="5387332at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="101" mass="11788" checksum="E8A61A965143C0C5" modified="2013-05-29" version="1">MVSKYSNKFHLKHNILKNPKNSCISRLNIKKKKGKKQFISEKFMKKLDDMTLDLYTLGLMKNSNTLQNIKKKTEKPSDIKTSYLDILAQVENNINSLQVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJT5</accession>
    <name>M7PJT5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal protein L37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00864</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872774.1">
        <property type="nucleotide sequence ID" value="XM_007874583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJT5"/>
    <dbReference type="STRING" id="1069680.M7PJT5"/>
    <dbReference type="GeneID" id="19894562"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00864"/>
    <dbReference type="eggNOG" id="KOG3475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150908_2_1_1"/>
    <dbReference type="OMA" id="RMAYLKH"/>
    <dbReference type="OrthoDB" id="10259236at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000001">
        <property type="entry name" value="Ribosomal protein L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00547">
        <property type="entry name" value="Ribosomal_eL37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_eL37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018267">
        <property type="entry name" value="Ribosomal_eL37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003214">
        <property type="entry name" value="PRK04179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01077">
        <property type="entry name" value="RIBOSOMAL_L37E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR10714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="91" mass="10798" checksum="1A5324CC5CF38C28" modified="2013-05-29" version="1">MTKGTSSFGKRHIKTHTQCRRCGRRSFHNQKSRCASCGYPASKMRRYNWSFKAIRRKTTGTGRMKHLKHVYQRYKNGFRTGETPRKTRLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7PK75</accession>
    <name>M7PK75_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00995</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872909.1">
        <property type="nucleotide sequence ID" value="XM_007874718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PK75"/>
    <dbReference type="STRING" id="1069680.M7PK75"/>
    <dbReference type="GeneID" id="19894693"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00995"/>
    <dbReference type="eggNOG" id="KOG1844">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020879_1_0_1"/>
    <dbReference type="OMA" id="PEKYWCE"/>
    <dbReference type="OrthoDB" id="79252at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061188">
        <property type="term" value="P:negative regulation of rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061186">
        <property type="term" value="P:negative regulation of silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053051">
        <property type="entry name" value="HDAC_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="30"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="226"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="229"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="248"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="450" mass="52490" checksum="1BE38BA5CD670AE7" modified="2013-05-29" version="1">MKMMFDRTTAELHRGLIRNGEELVIEETTRCVCGFQDVQNEESAERNLYIQCDHCLVWQHGACVGFRDEKSIPEIYYCEICRPDLHHVTYKAKAPPTSKYHQSSGNVESEWKSSLLKKRWTMNSRDAIYDSSLPEFDQKIFVEKASSEPIISSEKESDFLNKRKKRRNSDFPELSSYHEVKRIRRLSVSPRISLNTQSNDWEEEQATLMKKRKRMNMGIEVRKVAVKGRQGENKNKTKASEKKMKNVSLDNSDVAPNSSKTKQASLKVNAQSNANQLPHLEQKARSKAKAKKTSTIRHQHDTRQSQIQKDSEQTFSNVLNIIDKPSRPRIPQAKITMIEMKKRVAAILEYISRTQLEMVSDEEHRRRLFVPLLEKIDKEIKDKKENFPELDKKKITNSDSSKNNVETSSNIKTVNSIFHYNFDSFEMMENLTKQLLEWEEKFGSYRDKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7PKA1</accession>
    <name>M7PKA1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01025</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872938.1">
        <property type="nucleotide sequence ID" value="XM_007874747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PKA1"/>
    <dbReference type="STRING" id="1069680.M7PKA1"/>
    <dbReference type="GeneID" id="19894723"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01025"/>
    <dbReference type="eggNOG" id="KOG1962">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087648_0_1_1"/>
    <dbReference type="OMA" id="FIDCINR"/>
    <dbReference type="OrthoDB" id="435607at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF20">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="7">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="187" mass="22301" checksum="0D716D7A1805E389" modified="2013-05-29" version="1">MTLYYSLVFTLLVIQMVLFCFLILPLPKRLKRRLFTFISTSWFIAKIRYISKIIFIFILVLFFDSVNRVFRTVEEAKLGTSGSLRDAYRSDIQARKFYSQRNMYLCGFTLFLSLIIDRVYALTLQVLKYEELVNTIKTQSDEHVKSKALVEEITELKKRIVEKDKEFHELSERYSRETKTNESKKNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7PLG5</accession>
    <name>M7PLG5_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">V-type ATPase, C subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_00308</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872181.1">
        <property type="nucleotide sequence ID" value="XM_007873990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PLG5"/>
    <dbReference type="STRING" id="1069680.M7PLG5"/>
    <dbReference type="GeneID" id="19894006"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00308"/>
    <dbReference type="eggNOG" id="KOG0233">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085752_0_1_1"/>
    <dbReference type="OMA" id="MVNVACG"/>
    <dbReference type="OrthoDB" id="10264021at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18177">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18178">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000002">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="31"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="116"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR11279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="182" mass="19071" checksum="0929B9636E6E4658" modified="2013-05-29" version="1">MFPLVLANPSTEPSYIDDFFAKVSPYLWGLVGIGLCIGLSVTAAAWGIFITGTSIIGGGVKTPHIQTKNLISIIFCEVVAIYGIIMSIVFSTKLQEVVGPNLYTIQNYNTGYSLFWGGLTVGVCNLACGLAVGVTGSSVALADAQDPNLFVKILVIEIFGSIIGLFGLIVGLLISGKASNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWZ2</accession>
    <name>A0A0W4ZWZ2_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_04306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="KTW32887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613361.1">
        <property type="nucleotide sequence ID" value="XM_019757824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWZ2"/>
    <dbReference type="GeneID" id="30671588"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04306"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KTW32887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="71" mass="8382" checksum="46C1CB72F07B0FB1" modified="2016-03-16" version="1">MDPMLFTITYFLFFSIAFYSFTIFLEIQGISSTNNWYIIEFCMDSYLGLLNIKKNLEIVSNKDIQGFELID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWZ4</accession>
    <name>A0A0W4ZWZ4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_04287</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="KTW32900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874673.2">
        <property type="nucleotide sequence ID" value="XM_007876482.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWZ4"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZWZ4"/>
    <dbReference type="GeneID" id="19896343"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04287"/>
    <dbReference type="eggNOG" id="KOG1088">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CTTHFWG"/>
    <dbReference type="OrthoDB" id="1697690at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:7770001">
        <property type="term" value="C:mitochondrial pyruvate carrier complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050833">
        <property type="term" value="F:pyruvate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KTW32900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="122" mass="13898" checksum="553C796B8DE78374" modified="2016-03-16" version="1">MNSIVGSVQLTASKFTQWLKSPDFIKYLCSTHFWGPVSNFGIPLAAVTDLKKDPKIISGKMTLALIIYSATFARYAWMVNPRNYLLLGCHIVNETAQIVQGVRWLKYHKFTSSNNSIYHKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZX06</accession>
    <name>A0A0W4ZX06_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_04291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="KTW32904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613376.1">
        <property type="nucleotide sequence ID" value="XM_019757810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZX06"/>
    <dbReference type="GeneID" id="30671579"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04291"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KTW32904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="85" mass="10145" checksum="CF427C0BF6AF6F35" modified="2016-03-16" version="1">MTIIKHYFKSDKHYEYILLNINLIYRMCAKQAFWSTSKLYYTLAVSSIDSNFTYSLPCDLFLKFVLNIRSDNLLIVKYPHFIGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M7NIA8</accession>
    <name>M7NIA8_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_03447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875535.1">
        <property type="nucleotide sequence ID" value="XM_007877344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NIA8"/>
    <dbReference type="GeneID" id="19897134"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03447"/>
    <dbReference type="HOGENOM" id="CLU_1166259_0_0_1"/>
    <dbReference type="OrthoDB" id="5389960at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="238" mass="27505" checksum="F8962330342328CA" modified="2013-05-29" version="1">MVCLSIEEKDIFYIHEPIPTRSGYEALEVTLHTSDTTNQQAFLDLSEETEQIIRSAMKHLDIFGERIEMAKLLLPKCDFIQTISSDQTMNITTNNLKFTSQLVKDILKLRDDIREMKRHFIFLKKPHSILYLKQKSKILKKKNNITISLNGAKKNLEKEKSSKEGFKIFEKQLMARFPRLYSELSISQIETSNLINLEKTDSDFSNSALATAGHCKINDALFFDNKILDTGISYEFIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJP2</accession>
    <name>M7NJP2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major surface glycoprotein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02611</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08823.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613293.1">
        <property type="nucleotide sequence ID" value="XM_019757744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJP2"/>
    <dbReference type="STRING" id="1069680.M7NJP2"/>
    <dbReference type="GeneID" id="19896302"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02611"/>
    <dbReference type="eggNOG" id="KOG3544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010455_0_0_1"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021041">
        <property type="entry name" value="Maj_surf_glycoprot_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003330">
        <property type="entry name" value="MSG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02349">
        <property type="entry name" value="MSG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12373">
        <property type="entry name" value="Msg2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Major surface glycoprotein 2 C-terminal" evidence="3">
        <location>
            <begin position="794"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="674"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="959"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="628"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="696"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="748"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="967"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08823.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1010" mass="112874" checksum="84B21EA151CB8CF2" modified="2016-03-16" version="2">MYAYHKKIKMYGYFERIISRFRFDSPSHMLLRDKRWVEEVAQKEAAMAQPVKRQAAGQAAGNDEIKEEQVLGLIVKSGYNNDNKCEANLKPYCEELKKIYGKLESVDVKVNGLCENLYEKGKDRKQSDKFETELEALLRAFETAFQNLTDDLWIEYEGPKLDFSPVREKPRFPEKIEVENLYKKEEAKGIIVGKPKYKTLRDLALLLIKERNGKDEGEKCKKALEDCESFKHLDYGLEELCGDKDKEDRCKELVEVEDRCTNFKLELYLKGLSTEFEKDKESDYFSWGQVSKLVSREDCIKFESECFHLEGVCTNKIGKACENVRVACYKKGQDRVLNRYFQEGLKGLIGDLELVTENLEKCQKSVVGNYTKLKEDRRYFTKCHLPTKLCYELLDDVILQSEELEVVLNLRRDFPRKEDCVELKKKCKDLESDSYLNHEKCDTLNRRCEYLKVTEELRKRLLKRGDDALRTQGNCTAVLKKECEELSRRGKEDFSVSCALREETCSFMKIIEKIENGKRNETLVEELCTLFDPYCHQYIENCPDRLKKSNNAGREGVCLELEEKCKPFFEKLKLENELTHKLKGSLSDETKCKETLGKHCTEWKKEGNQTLNSLCEDAKKEELCKKLVKKVKEKCPTLKNKLDNEKDELEKKKDEYEKVKQESEKFAKEAKLVLSRPEQDGQGGGSKAQDGSVPKPVGPPVQPPAPAQPTPGGVPVPAPTLAPPAQPTSGGAPVPVPPAAPGGTPGGAPVPVPPPAPGTPPAGPAGPSGPSGGTPAGPPAPGGSTPSGTTNTSNVILVRRTFVSGEVSEPEKKAFVATARALELYLELKEKCKGLQGDCGFRKDCPGCEAACKEIDKLCEGIEGLKVTPHHTVISTATQTTTTTATTTTTTTTTTTTTTTTTTTATTTESVDGGKVTEECTLVQTTDTWVTSTSLHTSTLTSTSTVTSTVTLTSMRKCKPTRCTSDSSKETETQKEEEKEEEVKPNEGMKIRVPEMIKIMLLGVIVMGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLK2</accession>
    <name>M7NLK2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Chromodomain-helicase-DNA-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_02128</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874110.1">
        <property type="nucleotide sequence ID" value="XM_007875919.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NLK2"/>
    <dbReference type="GeneID" id="19895821"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02128"/>
    <dbReference type="eggNOG" id="KOG0384">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_29_2_1"/>
    <dbReference type="OMA" id="WVQIRDD"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030874">
        <property type="term" value="C:nucleolar chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140002">
        <property type="term" value="F:histone H3K4me3 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140750">
        <property type="term" value="F:nucleosome array spacer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000104">
        <property type="term" value="P:negative regulation of DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902275">
        <property type="term" value="P:regulation of chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001178">
        <property type="term" value="P:regulation of transcriptional start site selection at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18665">
        <property type="entry name" value="CD1_tandem_CHD1_yeast_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18659">
        <property type="entry name" value="CD2_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17993">
        <property type="entry name" value="DEXHc_CHD1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000007">
        <property type="entry name" value="Chromodomain-helicase-DNA-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000130">
        <property type="entry name" value="Chromodomain-helicase-DNA-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041150">
        <property type="entry name" value="Cdh1_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056302">
        <property type="entry name" value="CHD1-2/Hrp3_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025260">
        <property type="entry name" value="CHD1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF14">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18196">
        <property type="entry name" value="Cdh1_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13907">
        <property type="entry name" value="CHD1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23588">
        <property type="entry name" value="HTH_CHD1_Hrp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01176">
        <property type="entry name" value="DUF4208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Chromo" evidence="10">
        <location>
            <begin position="206"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="10">
        <location>
            <begin position="305"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="409"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="716"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="24"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1252"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1252"/>
            <end position="1262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR09542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1403" mass="163703" checksum="9847A73A1AE3843D" modified="2013-05-29" version="1">MVDENLSQTLNKVSEISTDCLEANGTLNNSSGEEFISETEDNMNDKDYNLSNNESESDEMEEAPRLRRRYQEKTKKQLETLDFSLYGLRRSERTRNEQVRSTNIDSSDDRISDEYGMISKKKRKKNYIRTQSIQSPVDSYESDFSDKLRKKQRAFLKDELRFSNRNLKTCNYNENSMDDDLDFTNDDENDYFYEKKLSSKSLETQDSIDAVLDHRQITKDDSDEFNDGHALEYLVKWKNHSHLHDSWETYDNLKKIRGWKKVDNYIKQYIDLDKQIRENPTTTAEYFEAMDIETERRRNLLVEYQTVDRIVSSRIVKSCEFDEHPHTEYFCKWKQLYYDSCTWECASAIFNAQDQIDRYLNRSVSHILPHESISYGSSRPKFKKLDVQPEYIKNGELRDFQLTGVNWMAYLWSKNENGILADEMGLGKTAQTVSFLSYLVHSLHIHGPFLIVVPLSTIPAWQENLETWATDLNSIIYIGNSKARKTIQEYEFYIDGNPKKIKFNILITTYEYILKDKSELNQIKWQYMAVDEAHRLKNSESQLYESLRDFRTANRLLITGTPLQNNIKELAALIDFLMPKRFEIDRELNFEAPNAEQEAYIRDLHKRLQPYILRRLKKDVEKSLPSKSERILRVELSELQTYWYKNILTRNYRALSMSTGNSQLNLLNIVIELKKASNHPYLFPNAEENWLNSIGSKRNREDILRGIIINSGKMILLDKLLTRLKRDGHRVLIFSQMVRMLDIIGDYLVLRGLSFQRLDGTVSASIRKASIDHFNASGSPDFVFLLSTRAGGLGINLMTADTVIIFDSDWNPQADLQAMARAHRIGQKSHVMVYRFVSKDTVEEDILERARRKMILEYAIISLGVTDKSNSGKADKFTAQELTAILKFGALNMFKDNDNQKRLEDMNLDDVLEHAENHDIGQDVGGASMGGEEFLKQFEVTDYKTDITWEDIIPEEERNRIEAEEKLRQDEEFLQEQISMNTKRTVKHPENLLIKDNISNKKLKKVDPKLRQLNEKEIRNLYRAILKFGSPLDRWEEVIREADLPNQMPPEKIRLIVRELFKACKQAIINQEAENKDVENSTLNQNSKPKKALLIEYKGVKNINAETVIQRARDLRFVHQLVKGVDSKVFRIPGQVKAVHGWSCQWGEREDAMLLIGIDRYGFGSWSSIKDDPDLNMQDKIFLDDDRTEKDEHKEGKELKDFKLIPGPTHLVRRGEYLLNLAREILEAKVASSSNNTLVVDRKVKNNYNIQSSGSLQQSKSRNVNHDLHSSKQSLKIKNDKKTKIKDNVDTEKKCDFDEESEHSSMDEDDCKKILHPVRKQLKTLKKDKDTDRTKLAMILKECLTTVGDFIEMTVASRSESDKDRLKKHLWVFTSYFWPKKIPYIHLLNMYNKLIAGRKDSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLT6</accession>
    <name>M7NLT6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major surface glycoprotein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_03332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08157.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875410.2">
        <property type="nucleotide sequence ID" value="XM_007877219.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLT6"/>
    <dbReference type="STRING" id="1069680.M7NLT6"/>
    <dbReference type="GeneID" id="19897019"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03332"/>
    <dbReference type="eggNOG" id="KOG3544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010455_0_0_1"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003330">
        <property type="entry name" value="MSG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02349">
        <property type="entry name" value="MSG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="760"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="526"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="707"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="767"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="782"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08157.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1005" mass="117143" checksum="82907A662674BB73" modified="2016-03-16" version="2">MLQNAKLLELLKIREFKRLRSGRLSRNFDGNYFGDHPGVDYFRKDDYDFFFPKDYPQDNQWVKEAIQKGAVMARSVKRQAAEQVAKDEIKGGTCFGFNCENELKNVSLELKNADPKKKVEKESKDLKKELLEAFKNIKDEDCRKYEDKCIFLEEADPINLKENRVKIKRVYEILFGNTVELVFSCLNPNVTCQRLKSRVEDVCTHLGRILNENELEEKCQEYLENCYFYKSNCGSTKYNIILEKIYEKEEVKGIISEKLQEKSLENIILLLSKEKNRKSLQEICKNVLNDCDFLYMNYHLKELSKEASKNIDSRCKELVKVETRYTNLKLELYLKELSTEFEKNKDSKYFSWEQVPKLPSKEDCIKFESECFYLENVCTNKIDKACENVRIVCYRKGQNRVFNKLIQNRLISLNYLKSYEVKLKECKELMVKNCIKFKGDKRYFLKCHRPTKLCYEFLEDIIDQSKEFEALLDSKRDFPKGNDCFKLIRKCHDLRTYSHSNNDRCTTLNIRCEYLEVREKFKKRFLERKDDSLKTKENCIKALKEECERLSRGKKNPFVTFCALPEETCNFIVKEVIDECYNLAYNMNDRNIINKIEKTNKALTKEICMFWDPYCHQYIENCPEILKQENINTKRAHCLKLQRYCTPLWENLRLEGELIHELKSSLINDTICKETLEKYYTKWKSEKNQTFDSASEDKNGSSEHLRRNVCKKLIEKVKRKCSALKNELDKEKDELKEKNEYEKVKKEAENFMKVTNLLLSKPKKNENGQSATLSVQNNSVLAPVAPSTAPPTAAESASSQGGTEHTTEQRLILRRFVDEGVSKTETNAFDLMTRALKLYLGMKEDCKTLQVNCGFRENCLNFGTVCEDIDKLCNVKPLEVIPHHTLILTTISTATRTATMPNNSDIDDNVTTSIKEAATEQCTLIRTINTSVIDTSLHTSTMTSTSAVTSTVTLTSMQECKPTRCTTDSSRKTKMRGKLISGQGMKMRVPKMIKIMLGVIVMRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NM75</accession>
    <name>M7NM75_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome b-c1 complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Complex III subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_03140</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UQCRQ/QCR8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875200.1">
        <property type="nucleotide sequence ID" value="XM_007877009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NM75"/>
    <dbReference type="STRING" id="1069680.M7NM75"/>
    <dbReference type="GeneID" id="19896827"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03140"/>
    <dbReference type="eggNOG" id="KOG4116">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_156007_0_1_1"/>
    <dbReference type="OMA" id="AGIYWYW"/>
    <dbReference type="OrthoDB" id="6683853at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.210:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.210">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004205">
        <property type="entry name" value="Cyt_bc1_su8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036642">
        <property type="entry name" value="Cyt_bc1_su8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119:SF2">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX UBIQUINONE-BINDING PROTEIN QP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02939">
        <property type="entry name" value="UcrQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81508">
        <property type="entry name" value="Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR08297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="88" mass="10011" checksum="8845824FFCB814D6" modified="2013-05-29" version="1">MGGGLGKKYMGWWGCMGGPTQKGIITYSLSPRAQHPFAGALHSAIFNTSRRCSQQILYFGIPLAVGYYIYVWANEKYKKYIRYPSLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMA2</accession>
    <name>M7NMA2_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873944.1">
        <property type="nucleotide sequence ID" value="XM_007875753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMA2"/>
    <dbReference type="GeneID" id="19895660"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01966"/>
    <dbReference type="HOGENOM" id="CLU_2134595_0_0_1"/>
    <dbReference type="OrthoDB" id="2391627at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019182">
        <property type="entry name" value="Cytochrome_b-c1_su10_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254:SF1">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09796">
        <property type="entry name" value="QCR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="113" mass="12763" checksum="11D03743DEA64F2F" modified="2013-05-29" version="1">MNALSGTKCIYLNISGFRKVSVCFSILFIYSSDLLETLKKNAFFFKTDQTYKKYLKKITQNGLVSLLIWSSSATLAVLFFSQGIPRVRTQIHQQLPVFGSSFNTDIPPSDIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMA5</accession>
    <name>M7NMA5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Elongation factor 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Eukaryotic elongation factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PNEG_03177</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Ribosome-dependent ATPase that functions in cytoplasmic translation elongation. Required for the ATP-dependent release of deacylated tRNA from the ribosomal E-site during protein biosynthesis. Stimulates the eEF1A-dependent binding of aminoacyl-tRNA to the ribosomal A-site, which has reduced affinity for tRNA as long as the E-site is occupied. Assists translation termination by stimulating the release of nascent protein from the ribosome by release factors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875240.1">
        <property type="nucleotide sequence ID" value="XM_007877049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMA5"/>
    <dbReference type="STRING" id="1069680.M7NMA5"/>
    <dbReference type="GeneID" id="19896864"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03177"/>
    <dbReference type="eggNOG" id="KOG0062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002848_0_0_1"/>
    <dbReference type="OMA" id="VLSEAMW"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000076">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000001">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040533">
        <property type="entry name" value="EF3_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047036">
        <property type="entry name" value="EF3_4HB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF5">
        <property type="entry name" value="ELONGATION FACTOR 3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17947">
        <property type="entry name" value="4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 20" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <feature type="repeat" description="HEAT" evidence="17">
        <location>
            <begin position="184"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="19">
        <location>
            <begin position="437"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="19">
        <location>
            <begin position="680"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1028"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="1032"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00060145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMR08337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1054" mass="119150" checksum="B438DC57AB10E7C4" modified="2013-05-29" version="1">MLPVVETTEQTHVPGNVVSPKVLMDLIPKLKISIRETDKNETIKSSEQLSVLSWDADVCERLYNTLKEQIESKDTSMREQALKALSLTLDTINQRVEPYMVQLLPEVLKRVGIDKVATIRTEAAIVAEGIIKTMNSYAIKTMLFYITDSIKTSGKWMEKMCAFRLLDMLVEKAPCQMSYRLPELIPVLSESMWDTKTEVKNQARKTMANVCSLISNPDIDKFIPVLIDCIAQPEKVPETIHTLGATTFVQEVHASTLSIMVPLLYRGLNERETAIKRKSAVIIDNMCKLVEDPYIIAPFLHKLIPTLEHIKETIGDPECRAVVNRSLATLIRVGNIKEGKIPEILNISEPKNCMETLLSILKGQELVPTSDVYLNYISCIASQLIDEKNNEIVDWNVNISPYLQPIILKADINYIIDQFRKRSISSFHSSSIELEEEEGEDLCNCEFSLAYGAKILLNRTFLNLKRGYRYGLCGPNGSGKSTLLRAISNGQVEGFPTELKTVYVEHDIDDTESKTSVIDFIANDPSVIVKDRQEAIDSLLSHSFTNDMLSIPISCLSGGWKMKLALVRAMLQHVDILLLDEPTNHLDLKNVAWLENFLTTQTHITSIIVSHDSGFLDNVVQAIIHYEHFKLKKYMGNMSKFITLVPSARSYQDISKSEIEFAFPEPGYLEGVKTKQRAICRMRDIEFQYEGTSEPQIRNVSLQVSLSSRIAVIGPNGAGKSTLIKILCGELVPQKGEVWCHPNLRIAYVAQAAFTHLGSHENKTPSEYIQWRYRTGEDSETIDRASRQLTENDEIHMNKIFKINGTSRRIQGIHSRRKLKNSYEYECSFLLGENVGEKNERWVPLNSMNNEWLPRSELIESHSKMIAEIDMKEALKFGSFRPLVRKEIEKHCENFGLDAEIVTHSRIKGLSGGQKVKLVLAAGSWLKPHVIVLDEPTNYLDRDSLGALSKALKSFEGGVVIITHSVEFTKNLTEEVWSVQNGQMTPSGHNWVQGQGTGPKLQEQDEEDTFDALGNKIEAKKKVKKLTSSELRKKKKERMARRKKGEDVFSSEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMF7</accession>
    <name>M7NMF7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_02034</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874014.1">
        <property type="nucleotide sequence ID" value="XM_007875823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMF7"/>
    <dbReference type="STRING" id="1069680.M7NMF7"/>
    <dbReference type="GeneID" id="19895728"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02034"/>
    <dbReference type="eggNOG" id="KOG1467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_3_1_1"/>
    <dbReference type="OMA" id="MRDYVIC"/>
    <dbReference type="OrthoDB" id="10254737at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233:SF14">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR09853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="428" mass="48119" checksum="83A578FCBC10A468" modified="2013-05-29" version="1">MQPLNSFFHGRHGSSCVLKGKNVEAKMGDGNTQNNSLTKEIKTKLKMEKIIKNSGRGVCESCEKSKKQLKNFQSTHNNEIVFNRQVFLFKHLDGDRRVNTQGTSKDIHPVILSLGLQYSEFKICGSNARCIFMLNSLKQVIQDYHTPSGTTLQRHLQSYINLHIAHLVLSRPLSVSMRNAIRFLKLEISNSSIDLGEDEAKNLLIKRIDRFIRDRITVADQVIVAAGQDKINNGDVILTYSRSSIVEQVLIEAYERHKLFRVIVVDSRPGFEGKECVRRLSRVGITSTYLTISSLSYIMREVTKVFLGAHAMLSNGALYSRVGTSIVAMTAKDNNIPVIVFCESYKFTDRVQLDSFVNNELGPTDNLVDISCGNCFKLGPLSSWYELANLKLLNLMYDVTPANFINVCISEMGILPSTSVSILVHEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMH2</accession>
    <name>M7NMH2_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PNEG_03253</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">B123</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875320.1">
        <property type="nucleotide sequence ID" value="XM_007877129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMH2"/>
    <dbReference type="STRING" id="1069680.M7NMH2"/>
    <dbReference type="GeneID" id="19896940"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03253"/>
    <dbReference type="eggNOG" id="KOG2518">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008978_5_1_1"/>
    <dbReference type="OrthoDB" id="26491at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09908">
        <property type="entry name" value="H3TH_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000011">
        <property type="entry name" value="exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000002">
        <property type="entry name" value="Exonuclease 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037315">
        <property type="entry name" value="EXO1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="16">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="15">
        <location>
            <begin position="138"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMR08417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="618" mass="71159" checksum="3AB59ED514AA1F48" modified="2013-05-29" version="1">MGISGLLPLLKSIQVKTHIKQYSGKTIGVDAYIWLYKGAFSCAWDLALGELTEKYVDYAMHRVRMLKHYGIKLFIVFDGGYLPSKEKTENQRGKRRAESKAKGLEFLSQNKKRLAMEQFQKCINVTPEMAYKFIKALRCENVDYVVAPYEADAQLAYLEKQGIIDAILTEDSDLLVFGCKCILLKLDQYGECIEIRREKFPQVKEIDLSGWSDENFRCMAILSGCDYLEGIPGVGLKTAYRLLKKHKTIDQLLRVIKLEYALKIPHDYEMQFNFANLTFMHQRVYCLDKKSIVMWNEPKTSLGDNIDRIAGPDIPADIVQGLISGEINPITRLPIFASLNEIQAFNKTKENIQSSNEYYMFSKQRKESSFNNHSIASFFASSTNNSRPQVLSVLNNNAKRLSTNDISRQTEVKHFKEAFQDKKHFISKINQENTHQTNYILNKINSSTHQKKANVHIIDEESQIKTAENTNNKEIDRKTVTIDLDNSHSSQFNSFQTSKSSECQILDECSWFNNVFSEKDNMHSKSQKIDIYEDKESYNNFISNWRQLHTHTSKDSSITHFPLFQIATQNTFLKHSLESTEECKISKGTSYVRKLPSCFKFSTNSTEKIGKKNILTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMJ4</accession>
    <name>M7NMJ4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_03181</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Lipid-anchor</topology>
            <topology evidence="11">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875244.1">
        <property type="nucleotide sequence ID" value="XM_007877053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMJ4"/>
    <dbReference type="STRING" id="1069680.M7NMJ4"/>
    <dbReference type="GeneID" id="19896868"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03181"/>
    <dbReference type="eggNOG" id="ENOG502QPST">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021855_2_1_1"/>
    <dbReference type="OMA" id="QDHTECM"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043188">
        <property type="term" value="C:cell septum edging"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000936">
        <property type="term" value="C:primary cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030476">
        <property type="term" value="P:ascospore wall assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000038">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF2">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 11" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9 11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="13">
        <location>
            <begin position="379"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR08341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="526" mass="59926" checksum="9B1F3E7A5378ECE8" modified="2013-05-29" version="1">MYLDYQVFYNIIFFYIIGYTYARIQTIYAYGNKLFYSNGTQFFIKGIAYQSPLEAGDPEHYRDPLAEPNACERDLRYFLDLGINTIRVYTVNPKNNHEYCMRLFEKNGIYVLLDLSEPRNSIISTDPSWNVKLFWRYSQVIDAMHKYPNLLGFFAGNEVILDTENTYSAAYVKAAIRDVKSYIKSKGYRKILVGYAANDHEHTRIPSANYFACGDSESAADFFGINIYEWCEPTSYETSGYSDRVNDFRHYNIPIFFSEYGCNIVNGKIGVRTFNQVPHIYSEKMTQVFSGGIVYEWFQNVNNYGLVNLMSDNTVSPRQDYINLREQIRHINPRPIQRSRYTPKNGPPECPVIGQYWSSSTKLPPIPNSELCTCASRASSCIAVNDITDTEIAEIFSYICGEINCKGVSKDSKAGVYGAYSVCEPIDQLNIILNLYYNKHKQESACNFKGLAYVVTSESSKTCSSLLRIVGMDGSGSITGPPVVAGFGEERGPRDRKDSSGKTIYPNWKLIFEIITYFFGITIFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMZ0</accession>
    <name>M7NMZ0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="3">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">N6-L-threonylcarbamoyladenine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_03073</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875129.1">
        <property type="nucleotide sequence ID" value="XM_007876938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMZ0"/>
    <dbReference type="STRING" id="1069680.M7NMZ0"/>
    <dbReference type="GeneID" id="19896760"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03073"/>
    <dbReference type="eggNOG" id="KOG2708">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023208_2_2_1"/>
    <dbReference type="OMA" id="NECSPAD"/>
    <dbReference type="OrthoDB" id="10254073at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd24132">
        <property type="entry name" value="ASKHA_NBD_OSGEP_like_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000038">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="11">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR08597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="263" mass="29355" checksum="DA50CCF969AA73D7" modified="2013-05-29" version="1">MGGPLQTVAIIARTLSILHNIPLVGVNHCIGHIEMGREITGAINPIILYVSGGNTQVIAYTKQRYRIFGETLDIAVGNCLDRFARTIYISNDPSPGYNIEKLAKKGKVLIELPYTVKGMDCSFSGILSAMESIANEFFDKNTKEFRKDSPYTKEDLCFSLQENVFSMLVEITERAMAHVDSKEVLIVGGVGCNERLQEMMNLMAQSRGGKLFSTDERFCIDNGLMIAHAGLLAYKTGFQTHISDSQCIQRFRTDEVHVTWRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMZ5</accession>
    <name>M7NMZ5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Chromatin-remodeling ATPase INO80</fullName>
            <ecNumber evidence="15">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PNEG_03078</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the INO80 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The DBINO region is involved in binding to DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="15"/>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875134.1">
        <property type="nucleotide sequence ID" value="XM_007876943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMZ5"/>
    <dbReference type="STRING" id="1069680.M7NMZ5"/>
    <dbReference type="GeneID" id="19896765"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03078"/>
    <dbReference type="eggNOG" id="KOG0388">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_20_1_1"/>
    <dbReference type="OMA" id="FWKKNER"/>
    <dbReference type="OrthoDB" id="372624at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032006">
        <property type="term" value="P:regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000022">
        <property type="entry name" value="Blast:Putative DNA helicase Ino80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001269">
        <property type="entry name" value="SNF2 family helicase/ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020838">
        <property type="entry name" value="DBINO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF2">
        <property type="entry name" value="CHROMATIN-REMODELING ATPASE INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13892">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51413">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DBINO" evidence="20">
        <location>
            <begin position="225"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="473"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="1048"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="297"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1221"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1226"/>
            <end position="1237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EMR08602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1243" mass="146022" checksum="49B145C2BB17AEFF" modified="2013-05-29" version="1">MESPDEQTDETADSTKEGINGGNGAEELTQFSEKGVGLRSQHGVKRVCSEGRYSEWPVKRKKPKNMSKNEVRNTFYGLNKGLDESKAEFMENIRQRLKKAKEDEEERIRVKRIKIQAMLIERLNNRAKKVFEKKSECSFNEVSFDQTYSELKDAKEVERKEKDIFRREKESSRKERSVFRERDIVEMNFSIDEETSGSEETYRPNKKARRNTNHLKTLEESITQIWKEISKKEVPKVYKMIQQNYTTRSSNSRKTALLCSKEAKRWQFRTNKNIKDMQARAKRAVREMLVFWKRNEKEEREQRKKEEKEAMEKAKKAEEQREATRQARKLNFLITQTELYSHFISRKIRTEETDNVDEIKDVSKDKEEKALIENSLEMTETPLNHCSIKDLDFDGVDDDSLRQIAIKNAQNAISLARDHAEQFNSTGESKNTFDGSEMNFMNPSSLGNVTIIQPKMLQCQLKEYQVKGLTWLVNLYEQGINGILADEMGLGKTVQSISVMAYLAENHNIWGPFFVIAPASTLHNWQQEITRFVPKLKVLPYWGNSKDRKILRKFWDRKQLTYTEDAPFHVLVTSYQLVVQDAQYFQRIKWQYMILDEAQAIKSSSSSRWKNLLDMKCRNRLLLTGTPIQNTMQELWALLHFIMPSLFDSHDEFSEWFSKDIESHAQSNTSLNEQQLQRLHMILKPFMLRRVKKHVQSELGEKIELEIYCNLSYRQKAYYKTLREKISIADIIEKAAQGGDENVASLMNIVMQFRKVCNHPYLFERIDVISPLCFAQWVETPSLMREGSNLYIPYSLKSLIKFHIPKLFYRNGGILNNHGPNSSFGFRIKYLNYIMNIFDSKYIYDSLWKNHHDSPFSWSYFIGLSPSELSRLFHYNIWKRALRSRMDLNKRYIAKLHLLYEDIQIPDRFMFFIKKFTEHTSILDIENGSAMYNLCNVSRIVFIEQLLHRLEPMYDQKVSSPPIDAECIDRTFTIEQQQFFFDENLKKEFLGITVFDEKNIIDKNIDLNNIEFPVESILGKPLLEKSSFGRLRMPSMSRFVTDSGKLAKLDELLAVLKTGGHRVLIYFQMTKMIDLMEEYLTYRQYKYLRLDGSSKINDRRDMVNDWQTRPEIFVFLLSTRAGGLGINLTAADTVIFYDSDWNPSSDAQATDRAHRIGQMKQVTVYRFVTRGTIEERILERAKQKQQVQNIVISGGKSIDFGKNHREVVSWLLNDNELEKIQEHQNQKNSKSNSSQKSTSKKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN04</accession>
    <name>M7NN04_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major surface glycoprotein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_03331</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08506.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875408.2">
        <property type="nucleotide sequence ID" value="XM_007877217.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN04"/>
    <dbReference type="STRING" id="1069680.M7NN04"/>
    <dbReference type="GeneID" id="19897018"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03331"/>
    <dbReference type="eggNOG" id="KOG3544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010455_0_0_1"/>
    <dbReference type="OrthoDB" id="5400168at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021041">
        <property type="entry name" value="Maj_surf_glycoprot_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003330">
        <property type="entry name" value="MSG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02349">
        <property type="entry name" value="MSG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12373">
        <property type="entry name" value="Msg2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006963412" description="Major surface glycoprotein 2 C-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="domain" description="Major surface glycoprotein 2 C-terminal" evidence="4">
        <location>
            <begin position="846"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="804"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1012"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="752"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="821"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="832"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1020"/>
            <end position="1040"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08506.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1063" mass="121488" checksum="FD3217A2BEDF48C3" modified="2016-03-16" version="2">MINKIILIAILNLIALIYGNQNVDLSIRSSQKNAVNPSFKDFIIKEDIYTFILKKDYNDENKCKAKLEEYCEELKDIDPELNKVDTNIKEICNSNDKGQKCKDLKPNIQKNLDQLSDELYIQSQKYIDNINANKNILRCLFLSDLNKNILEYCYFLEYYYRKNEHLKLMNEVILHKKMKEICPILVQQGINFIFGCFQIERSFKELNKYINYSCNSLNINLNDNELQEQCYEKLKSCYFLKNKCEKKCNELKVLCEKKNITYKLPGKDYNPIKPETTLLKIELEDFYKKMKDKGIYIENLETTLDNILIYMSNIHPGFSESKCKNVLNKSCDFFKFLSPELKELCQDNIEKRCKDASEITYKCRKFKMTLYLAGFSTHFQDDILGNEIPWDRLSTSLNSREFSNFNTNCFYIAGSCKNMFLEGCRNVNQANSKKLQEQSFIKLIESKLVEEQYNLKSKDEKLKICQKIVMEKCVALANSNIKNFLICLRPKEICLRLEEIIFTLSKDLEQALDQARDFPKEEDCVELKKECEGILKDLGSNNVKCVTLKKRCKYLEVTKELKYDFLKDKSDSLTNIQNCMKALKEKCDRLFKRGTNAFGVSCALPEETCKFMVSEVENHCNAFKNNIEKHDILNKSKNGNETLVEEICILWDPYCDELMENCPDKLKKGDNGNEKGVCLQLKENCRPFFEKLKLEDELTHELKGSLGKDDECKKALGKHCSERKNSGNQKFNSFCNTDKDKDVEEKVCKKLVEKVKEKCPTLESELGKEKDELKKKKDEYEKVKQESEKFSEEVKLLLSRLGKDGQDAGSKVQNTSATEPAAPPGGAPAPAVPGGSTPSGGANTSNVILVRRTFVSGEVSEAEKKAFDETAKALELYLGLKEKCKGLKGECGFRKDCPKCDAVCTEIDKLCEGIEGLKVTPYHTVSLIMREIMTTTMITAATTTTTTTTTTTTTTTTTTATKSIHGGKVTEQCAFPQTTDIWMTSTSLHTSTMTSTSTVTSTVTLTSMRKCKPTRCTSDSSKETETQKEEEKEEKAKQNEGMKMRVPEIVKIILLGVMVIGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN89</accession>
    <name>M7NN89_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Jacalin-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875118.1">
        <property type="nucleotide sequence ID" value="XM_007876927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN89"/>
    <dbReference type="STRING" id="1069680.M7NN89"/>
    <dbReference type="GeneID" id="19896749"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03062"/>
    <dbReference type="eggNOG" id="KOG4525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009601_2_1_1"/>
    <dbReference type="OMA" id="MFRNNFG"/>
    <dbReference type="OrthoDB" id="74460at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053002">
        <property type="entry name" value="Metalloproteinase_M10B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021917">
        <property type="entry name" value="Unchr_Zn-peptidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054:SF2">
        <property type="entry name" value="MIP04191P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054">
        <property type="entry name" value="ZINC METALLOPROTEINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01419">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12044">
        <property type="entry name" value="Metallopep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00915">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51752">
        <property type="entry name" value="JACALIN_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Jacalin-type lectin" evidence="1">
        <location>
            <begin position="521"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="665" mass="75634" checksum="1C012F216CBAB226" modified="2013-05-29" version="1">MCRTKTCWIPGISRKQTDLIKEKYAPRIENILSGETVYQRIILVYGRAGTKDIKEGTIVVHHDKNSFPSQTWPCIKSHFKCLVHLNEGMNCLTFEFFPPHNMSIQFSTVIFLNYINVVKNPPLYLVILLAKDSPEEYDAPPSRKEKEGNGLELAIKKLRMIAYLWQAFTGEKMARNGFGRRCFRFEEENLIDTLSSQEKDIIRQTAKIHIVRSKYSLKEIRDVNLAQQNPAATKKDGLYEIALESIREYGDVFKSESPVHVAACILDSHWDGKMILGHAALGGGTDLQRLAIFGSHSMHCFPSCIEEVVPTFLDDTAIDTRYVANDNNESSTIWECANIGIGAFLHEVGHLLGAPHRSTGIMHRDYVHFNRTFCTIEPYSARTKKESWGPCLPESECSWHYLDMIKFRYHKLFALPDDPIIEAGNLLYYSMKDKFLVMSDEGVILIEIYANDKYYAYLDFHDNSKKEILLEEQSLRKYAKIPNNIQPLKAIITSAALCEITIEDFKKELLDSTVSLDAGLGIKSFQFGRSDEALLKFQFDFSNKLDKLSNICIRSGLFIDGLKFIFNNESTMATSGNGGNLNNFPIDGPKGERIKGLYIWSNAWIDALQIITTWNRTSPLYGTVSGHYKYVTTPEGYEIAGFYGSTGKWCNTLGVIYIDKKQLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNE5</accession>
    <name>M7NNE5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 54 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873430.1">
        <property type="nucleotide sequence ID" value="XM_007875239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNE5"/>
    <dbReference type="STRING" id="1069680.M7NNE5"/>
    <dbReference type="GeneID" id="19895186"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01490"/>
    <dbReference type="eggNOG" id="KOG2115">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003094_1_0_1"/>
    <dbReference type="OMA" id="QKQAVML"/>
    <dbReference type="OrthoDB" id="10259024at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039745">
        <property type="entry name" value="Vps54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012501">
        <property type="entry name" value="Vps54_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07928">
        <property type="entry name" value="Vps54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 C-terminal" evidence="7">
        <location>
            <begin position="674"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="933" mass="108323" checksum="31BE36742F56467E" modified="2013-05-29" version="1">MQKQESSEFLISDRIFDICYVLSGPYQKENSERPTAKDIHPVHLTSIPNYKISDFQEYLSKINQEYRRYCLYRFREIDGNLYELEKDILKLNFNDYDTNSSSRSSLSFDNHFESLRPNKEYISKFSSEKKLVTIEESLSSIPLVYFKSNFELENSRIFDLVADNSKISSENFVSSNCNTFSNNSILQEKLSWYLDIVEVHLIKEINSLSPLFFSVIDYLQGLHKVSSNCIDKIKELRTKLINNNDTFVEPRLKIIEILRKKENLDRLTLALKHVYNILSEFSEIGDLIKKKDYVHALNIIEKISEEIKGNLDGSSNISLSNVIALSSLGKELQIFKEEIREKLLLEFVNELIKDHKQVILYVSPETITEIYLNFQKKNKINKNSSLQYIDLDEDLRKKIETLIIGLYMTDSIEDVLKSYYDAILKEVKNILVYNILDSNNPVDVDLFLNPITKEHTILVNLLKEMTPKNFLQTIGTIYALVYLFIRRLSIYQKFFLDITSNLVEFNFADKSKSLKSIDISNILIAVVNFIESEMVTILDIRNYQNSKFSENNVFHFFSLNTMFLSQSEILTGKSGELLQKTVLAQVKQSINNYHAKKMSQETLILDRDRWLPEKYVTEELENAIFCIIDSAVTDPISWKKDFLFNEIEDSKSDVSSVDSTNDSSKKSFVIIEDKKYFIIESLAFLILIFQNYTKFFILIPSMAYDISNNLLELLELYNFKVSQLILGAGAIKTLGFKTITARHLALASHSLSLIMHLISYILEFMKRHVGNLDLSEFDQIKKAYQEHQSEIHMKFVSIMTDRLDVFMNSSSGGLKTLDWSKPLLQAEDGTLKAHSYMESLVKDILTLNKILTKYLKQDTIQDVMFKVLDIYINLLSKKYNTLSLDIHNIEEYIFVDVKYFSDNIATLGHIGQEASCKILKNVESMFKERKENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNF5</accession>
    <name>M7NNF5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BolA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875188.1">
        <property type="nucleotide sequence ID" value="XM_007876997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNF5"/>
    <dbReference type="STRING" id="1069680.M7NNF5"/>
    <dbReference type="GeneID" id="19896817"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03130"/>
    <dbReference type="eggNOG" id="KOG2313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109462_2_0_1"/>
    <dbReference type="OMA" id="CLGGFGK"/>
    <dbReference type="OrthoDB" id="411584at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044572">
        <property type="term" value="P:[4Fe-4S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230:SF7">
        <property type="entry name" value="BOLA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="11225" checksum="D9F8666EC3914A0E" modified="2013-05-29" version="1">MSLNYLHSTESIIRQKLTKALSPSILEIYNDSYLHKYHAPMKNNTNLESHFRIIIVSDAFKGHGQVARHKIVYNLLKEELENGIHALQLYTKTCEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNI6</accession>
    <name>M7NNI6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RAD50-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_02971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875017.1">
        <property type="nucleotide sequence ID" value="XM_007876826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNI6"/>
    <dbReference type="STRING" id="1069680.M7NNI6"/>
    <dbReference type="GeneID" id="19896658"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02971"/>
    <dbReference type="eggNOG" id="KOG2218">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015529_1_0_1"/>
    <dbReference type="OMA" id="GMTWEVL"/>
    <dbReference type="OrthoDB" id="2189254at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060628">
        <property type="term" value="P:regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1420">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007528">
        <property type="entry name" value="RINT1_Tip20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042042">
        <property type="entry name" value="Tip20p_domB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520:SF0">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1 RINT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04437">
        <property type="entry name" value="RINT1_TIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51386">
        <property type="entry name" value="RINT1_TIP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="810" mass="95810" checksum="1AAB2C8A933C8D25" modified="2013-05-29" version="1">MNHTHIPGSWIDSPTGHSKINLFQTKISSMKPYNTVQSQYLEEINKYLKKPEDIKAVDSYIESLEKELNIFKLQEKKETDELIYIKDKMNKNAEKVKIYCEIVKNYLKNTSEPFLWESKEEKIFFDELYTSIKYLKNLEVSKTYLLILIQVEKLSYLIEECIETDKKTALISYHQLIQWNYNLKKSNKNSEKPLVHLEMFIQERLRSSWDIIEIKLCQDFHSHFEEIGWPDKIKKGISPSTESFKRFQSSFQTLLIQHREIIRSLENKDENLECTETNNSDILLPFLIMVRPLNIQFRYHFMEKRKTDRIDKPEWFYTYILDIISSCANFFCIEVQNIINETPEHNRNSLNEFITALLKIVEEKIETSIEYLLMNVHVFSHFVHETIKFDNILRHDFGYFPYKGQWNGMIHIALGNSKNFMTWVESEKKFSIEQFQNIIDVTMSPNTWDLDYDSVGESETKPTNSSLRIKCLIESITEQYRPLKDFNQKSIFFTEIQCHILNSYYERLKSAADAFEVTFSRIIQAVSGNKTDKMIQDVKGLETLCRVYGSCIFIESCLSDWDDDIFFLELWQNLTTKNKTIYEANTNSKNPNSLLEYGQGSLFSKISLLYFNLHERTEKLIIRHLEREIKEKFQPYFKIYTWSSLENPSSSIAMSSPVSMQMVDALKLVNSLLNFLKRAVSHLTFLRIYKQFSLTVENLLWKKIILKNDFSERGGIQFTRDIWEFWATCSKYVEKPEQNMKKIEDATILLSLNSSNENDKKSISTVASIIFDTYKSFEEKKQYLKTIGLKHINIAEARDILQKRIDCWAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNV1</accession>
    <name>M7NNV1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 14">DNA replication licensing factor MCM6</fullName>
            <ecNumber evidence="3 14">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PNEG_02937</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 14"/>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874981.1">
        <property type="nucleotide sequence ID" value="XM_007876790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNV1"/>
    <dbReference type="STRING" id="1069680.M7NNV1"/>
    <dbReference type="GeneID" id="19896624"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02937"/>
    <dbReference type="eggNOG" id="KOG0480">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000995_3_0_1"/>
    <dbReference type="OMA" id="RHQQTDK"/>
    <dbReference type="OrthoDB" id="1744952at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033679">
        <property type="term" value="F:3'-5' DNA/RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006267">
        <property type="term" value="P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17757">
        <property type="entry name" value="MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.870:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000115">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008049">
        <property type="entry name" value="MCM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18263">
        <property type="entry name" value="WHD_MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01662">
        <property type="entry name" value="MCMPROTEIN6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 14" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="15">
        <location>
            <begin position="396"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMR08766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="851" mass="96647" checksum="0DF54D35FD29EF59" modified="2013-05-29" version="1">MSSIDFSSQATVPFHTEVDETSSHLQIQRRRLQSTAIPKVTDITGEKVRESFESFVENYIESDPVSGTRKKYYLEQIHGMKSYEITTLYVDYMHLLDYENSALAEALVEQYYRFLPFLIRALHRLVERYEPTYYRTAISQATNVSKISTDKTFHIAFYGFPLVSKIRDLRTDRIGKLISISGTVTRTSEVRPELSRATFICEACKAVVTNVEQIFRYTEPSQCPNEICRNQKHWRLNISQSTFVDWQKVRIQENSSEIPAGSMPRTLDVILRGEIVERVKAGDKSVFTGSLIVIPDISQLGLPGVRPEAMRDTRGSGRTRDGFAIEGITGLKTLGVRDLTYRLAFLACMAQSTSNRDISVPDIHGETQEKEQDIFLNSLSQNEIDELKKMVHTDRIYSKLVNSIAPTIYGHEIIKKGILLQLMGGVHKITPEGINLRGDINICIVGDPSTSKSQFLKYVCGFLPRTVYTSGKASSAAGLTAAVVRDEETGEFTIEAGALMLADDGICAIDEFDKMDISDQVAIHEAMEQQTISIAKAGIHVTLNARTSILAAANPVGGRYNRKATLRANIQMSPPIMSRFDLFFVILDECNEAVDTNLARHIVDIHRLRDNSVKSEFSTEQLQRYIRYARTFKPKLTPEAQTELIKRYKELRIDDAQGMGKNSYRITVRQLESLIRLSEAIARANCVEDITPKFVVEAYNLLRQSIIYIERDDIGLDDDIKQSEVGNTEIQNVNPIKKEKTKITYDKYISILNMIIKRLKEEEQNVEGVEEEDLVQWYLEQKENEILTEDALIVEESLIKKVLKKLVKDHYIMELYGEGIESETEKPIRKVYVIHPNAEVDFLDSFPTSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNY8</accession>
    <name>M7NNY8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Maintenance of ploidy protein mob2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873048.1">
        <property type="nucleotide sequence ID" value="XM_007874857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNY8"/>
    <dbReference type="STRING" id="1069680.M7NNY8"/>
    <dbReference type="GeneID" id="19894830"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01133"/>
    <dbReference type="eggNOG" id="KOG0440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038321_3_2_1"/>
    <dbReference type="OMA" id="ILCNPAP"/>
    <dbReference type="OrthoDB" id="10261121at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902554">
        <property type="term" value="C:serine/threonine protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007118">
        <property type="term" value="P:budding cell apical bud growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062200">
        <property type="term" value="P:RAM/MOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000100">
        <property type="term" value="P:regulation of establishment or maintenance of bipolar cell polarity regulating cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000920">
        <property type="term" value="P:septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="26398" checksum="5645C5F8EDEE916A" modified="2013-05-29" version="1">MSFFNSFGKIGKYSRLKKSSITTYTQNSQQDHRKLFLYQPFVKTALVKGSFATIVALPKYVDLNEWLALNVFEFFTYLNQFYGVFAEFCTPQNCPSMSASSSVNYMWLDGNRKQIQLSAPQYIDCVLAWVNNRLSDENVFPTKAGHRFPSNFFIIVKSIYKQLFRIFAHIYYSHFDKILHLSLEAHWNSFFAHFISFGKEFELLDKHDVEPLRDLIDLMVKTGIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP71</accession>
    <name>M7NP71_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP-dependent RNA helicase DBP8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_01220</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873138.1">
        <property type="nucleotide sequence ID" value="XM_007874947.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP71"/>
    <dbReference type="STRING" id="1069680.M7NP71"/>
    <dbReference type="GeneID" id="19894917"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01220"/>
    <dbReference type="eggNOG" id="KOG0340">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IMIFTDT"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17955">
        <property type="entry name" value="DEADc_DDX49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="13">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="75"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="283"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR10508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="52158" checksum="855DC30044CCE9BD" modified="2013-05-29" version="1">MSGTETLIETADTMNGQTEIDNKTISKPNLLHKKVSSDSETSNISFKACGLHSWLIETLEKIAITKPTAIQAACITPILEGKNCIGNAKTGSGKTMAFALPIVQKLTQDPYGVFALILTPTRELALQISDQLAILGTSVDLKQATIVGGMDMMTQALTLVKRPHIIIATPGRLADHIRSSGQETIDAFKRVRFLVLDEADRLLSPGFSKDIQKCIEILPEANNRQTLLFTATITDSIKNLKIQSSKPGKKPLFLYNITESPIAVPSSLIQTYIFIPSYVKEAYLYRIFNTQEYKEKSIIIFTNRTRTTELLCRMFRILDFKVTALHSEMPQKERTQSLRKFKEEASKILIATDIVSRGLDIPFVELVINYDVPKDPDDYIHRVGRTARAGKSGESITLVSQRDILLIQAIEKRINAKMEKNPHVSDFKVAQELNTISAARIEAEMSMTNFGQLKENNKRKLENLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPE6</accession>
    <name>M7NPE6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EIF1AD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874484.1">
        <property type="nucleotide sequence ID" value="XM_007876293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPE6"/>
    <dbReference type="STRING" id="1069680.M7NPE6"/>
    <dbReference type="GeneID" id="19896168"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02475"/>
    <dbReference type="eggNOG" id="KOG2925">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106477_4_0_1"/>
    <dbReference type="OMA" id="WRKQSYW"/>
    <dbReference type="OrthoDB" id="1738325at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039294">
        <property type="entry name" value="EIF1AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21641:SF0">
        <property type="entry name" value="RNA-BINDING PROTEIN EIF1AD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21641">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="24"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="105" mass="12427" checksum="31E4425C06816DEA" modified="2013-05-29" version="1">MFRKKIQKLGQITLDPPHELPIYQKIAHVVEIRDHDLYLCKTADGETLLAELPARFRCKIWVRRGGFVVIDTHEFDKKGGKIQAEITIIIQNEKIWKKKKYWLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPJ4</accession>
    <name>M7NPJ4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear cap-binding protein subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">20 kDa nuclear cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02794</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RRM NCBP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874827.1">
        <property type="nucleotide sequence ID" value="XM_007876636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPJ4"/>
    <dbReference type="STRING" id="1069680.M7NPJ4"/>
    <dbReference type="GeneID" id="19896483"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02794"/>
    <dbReference type="eggNOG" id="KOG0121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070952_1_1_1"/>
    <dbReference type="OMA" id="DIRRIIM"/>
    <dbReference type="OrthoDB" id="201398at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12240">
        <property type="entry name" value="RRM_NCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000399">
        <property type="entry name" value="Nuclear cap-binding protein subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027157">
        <property type="entry name" value="NCBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034148">
        <property type="entry name" value="NCBP2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847">
        <property type="entry name" value="20 KD NUCLEAR CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="31"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="112"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="172" mass="20263" checksum="A0F99BCF66CB329F" modified="2013-05-29" version="1">MSILQRLDTPSTYVDRYSKRSNKDMPLNRSSTLYVGNLSFYTTEEQIYELFSKCGEIKRVIMGLDRFNKTPCGFCFVEYYSHEHALDCMKFINGTKLDDRVIRTDIDPGFREGRQYGRGRSGGQVRDEYRTEYDPGRGGWGYRRAEERQKNIQQKHRSDQDLNRLSQSPEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPM4</accession>
    <name>M7NPM4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">OPT family oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01357</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873287.1">
        <property type="nucleotide sequence ID" value="XM_007875096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPM4"/>
    <dbReference type="STRING" id="1069680.M7NPM4"/>
    <dbReference type="GeneID" id="19895054"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01357"/>
    <dbReference type="eggNOG" id="ENOG502QUDW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010539_1_0_1"/>
    <dbReference type="OMA" id="GIGMYLP"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645:SF3">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="564"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="636"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="667"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="705"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="751" mass="81912" checksum="BC8E2345F1314D61" modified="2013-05-29" version="1">MADTEDKSAELLDKVEGEAQETQDTEKIDEKSGLEVEDKLPGTYTDEKVQVPETLEGDSFSLTYDIQQGNPFPENPNAPPELHQLTIRALVVGTFLGSVVASSNIYLGLKTGFTFGAQLFGAIFGFAILQFVSKMMPEWFGGGFFGPKENCTVQTAATAAGGMAGMFVSSVPAMYSLSLLGKGPEEDFWRLISFTAVSAYYGLFFVIPLRRFYIIYQKLVFPTSSACALTIHSLHSGAVAHSVMKKKVWSLSISFLVSIVLRVLSDYAPGILWDWHIFWWLYQSGWKGAIAAENWGWWIELTPAFFGVGFFSGLNAATSFFLGTVIAWAVIGPIISKTGLAPHFSVISPGHTDWRSYSSMSLQSSLNPNGFDPIKTSSPRYWLLWPGVMLMLCSSFAEVIMNGTLLWVGLKRIILVIYYKIRRKEIPVFKNAIKDPAPPETQIPAWQWIPLLIISIIFTCLVLTLQYGINVGLALLSILLGFIFSFIGAQSSGATDVNPVSICAKSSQLIFGSISSAQRMDEILAQRLNLIAGTVASSSASQSVDMIGDLKTGHLLGAYPKIQFYAQVIGSFFSIWLSVALYILFNKAYPCFTAQFMPGYPSSQKCVFGAPSVASWRAVASAMTNERLPVPSSSGYASIILGIISALVVVLKYSYCPEKYRVFIPNFNAIGLGFVVPQTHYATAMFIGALVAYFWKKSKPVSYDIYALSIATGFAAGEGMGGVINAILQIAGFSGSTYGTIVGCPYESWCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPP1</accession>
    <name>M7NPP1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Major surface glycoprotein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09071.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613297.1">
        <property type="nucleotide sequence ID" value="XM_019757742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPP1"/>
    <dbReference type="STRING" id="1069680.M7NPP1"/>
    <dbReference type="GeneID" id="19896110"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02417"/>
    <dbReference type="HOGENOM" id="CLU_441870_0_0_1"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021041">
        <property type="entry name" value="Maj_surf_glycoprot_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003330">
        <property type="entry name" value="MSG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02349">
        <property type="entry name" value="MSG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12373">
        <property type="entry name" value="Msg2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Major surface glycoprotein 2 C-terminal" evidence="2">
        <location>
            <begin position="902"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="752"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1067"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="794"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="846"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1075"/>
            <end position="1094"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09071.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1118" mass="124854" checksum="971ADAB9181F0272" modified="2016-03-16" version="2">MPLRDKRWVEEVAQKEAAMAQPVKRQAAGQAAGNDEIKEEQVLGLIVKKEYNDDNNCKEKLEQYCAELKKIDGKLENVDAKVKGLYLTDENCKKCEEKCVLLEEADPSNLEDNCVKLRDRCYGQRRRGVTKEILLTALKGKVNDTKECKKKMKEIWQGLIEYSDELLLLCFNSNKTCEYLKTKHVDNCLPFETELEDKELVEKCQEYLEKCYFYGSSCKNTKCDKVKNKCKGKGIEYEGPKLDFSPVKEKPRFPEKIEVENLYKRLGAKGIIVGKPKYKTLQDLILLLIKGRTEKDNKEKCKEALKGCEFFKHLDYELEELCEDKDKDKENKCKELVEVEDKCTNLKLELYLKGLSTEFEKDKESEYFSWEQVSKLVSREDCRKFESECFHLESVCTNKIEKACENVRVACYKKGQDRMLNRYFQEGLKGLIGNLGLADENLKECQKSVVGNYTKLKKDRRYFAKCHRPTELCYELLDDVILQSEELEVVLNLRRDFPRKEDCVELKKKCEDLESDSYLNHEKCDTLNRRCEYLKVTEELRKRLLKRGDDALRTQGNCTAVLKKECEELSRRGKEDFSVSCALREETCSFMVEQTENECLFLKNNMENGKIIDKIEKGKGNETLVEELCTLFDPYCHQYIENCPDRLKKANNAGGKGVCLELEEKCKPFFEKLKLENELTHELKGSLSDETECKKALEKHCSEQKNSANQKFNSLCNTDKDKSVEGRVCKKLVEKVKRKCPTLKNKLDKEKDELEKKKDEYEKVKQESEKFTKEAKLVLSKPEQDGQDGNAPKPGGPPVQPPVPGGTPGGVPVPAPTLVPPAQPTSGGAPLPVPPAAPGAPGAPGAPGAPAGPAAPGTPSTPSTPPAGPAGPSGGTPAAPAGPAGPPAPGGSTPSGTTNTSNVILVRRTFVSGEVSEAEKKAFVATARALELYLELKEKCKGLQGDCGFRKDCPGCEAACKEIDKLCEGIEGLKVTPHHTVISTATQTTTTTATTTTTTTTTTTTTTTTTTTATTTESVDGGKVTEECTLVQTTDTWVTSTSLHTSTLTSTSTVTSTVTLTSMRKCKPTRCTSDSSKETETQKEEEKEEEVKPNEGMKIRVPEMIKIMLLGVIVMGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPQ7</accession>
    <name>M7NPQ7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anaphase-promoting complex subunit 15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_02572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874587.1">
        <property type="nucleotide sequence ID" value="XM_007876396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPQ7"/>
    <dbReference type="STRING" id="1069680.M7NPQ7"/>
    <dbReference type="GeneID" id="19896264"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02572"/>
    <dbReference type="eggNOG" id="ENOG502SGKU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1525804_0_0_1"/>
    <dbReference type="OrthoDB" id="5320532at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008402">
        <property type="entry name" value="APC_su15/mnd2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05841">
        <property type="entry name" value="Apc15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR09237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="20767" checksum="D6714B068AAAD809" modified="2013-05-29" version="1">MKPLIFPSLFPQDLHSLWYKPHHLLSDSGSQIGKSQLDLDEAEYENKKLVIRSFGSTWIRPVGIQQTIREQEELESAMNEEMDEDDEINQDPSLGEVGHEDVEEADLDAAIPEVISSEQGSDEFEDSFQSFLQSHNQRRQLAETSIDISLSPFDPLRQRALEIDSGLDVHDGDIMVWDGNVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2024-01-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ90</accession>
    <name>M7NQ90_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_03604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873017.1">
        <property type="nucleotide sequence ID" value="XM_007874826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ90"/>
    <dbReference type="GeneID" id="19897291"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03604"/>
    <dbReference type="HOGENOM" id="CLU_2237737_0_0_1"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="105" mass="12890" checksum="3B30A9AF927CC6BF" modified="2013-05-29" version="1">MRNSKIKSINLHIHLHEFWDVNVYVGEKYKRIFIHLDLWIEIIENQIKKNEPYTSKDIWNLLYEFSKDIQIDFGIYNKIHDQQKRKKGIYIEILCCISKKRLQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQP1</accession>
    <name>M7NQP1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872540.1">
        <property type="nucleotide sequence ID" value="XM_007874349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQP1"/>
    <dbReference type="STRING" id="1069680.M7NQP1"/>
    <dbReference type="GeneID" id="19894338"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00640"/>
    <dbReference type="eggNOG" id="ENOG502S0A4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1384882_0_0_1"/>
    <dbReference type="OMA" id="CSQFFVG"/>
    <dbReference type="OrthoDB" id="6021263at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024388">
        <property type="entry name" value="Ribosomal_mL58"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12824">
        <property type="entry name" value="MRP-L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="180" mass="21337" checksum="A82B97B191AFD556" modified="2013-05-29" version="1">MILTNSYLFLKYIRWASSGPRSTKHPRHRIPKLKPIPEGILLQKELNSELFYNPPSSPPDYKVTPYSLLPDEVKKLTEKPVFQGKLPPPLSPIKKKKYNLTEEDIKEIKILRENGISRSELAKRYNASRLFIGMVSSLSKEKLQEIEKKNQEIRDSWSEHKKEVKMNRYKRKKLWKQEYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQT4</accession>
    <name>M7NQT4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_02206</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM U1 A/B'' family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874189.1">
        <property type="nucleotide sequence ID" value="XM_007875998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQT4"/>
    <dbReference type="STRING" id="1069680.M7NQT4"/>
    <dbReference type="GeneID" id="19895899"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02206"/>
    <dbReference type="eggNOG" id="KOG4206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041869_0_1_1"/>
    <dbReference type="OMA" id="VRMIPTK"/>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017069">
        <property type="term" value="F:snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12247">
        <property type="entry name" value="RRM2_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000039">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000029">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051183">
        <property type="entry name" value="U1_U11-U12_snRNP_70-35kDa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="29"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="174"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR09622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="247" mass="27754" checksum="AF2A0C848B9053C5" modified="2013-05-29" version="1">MELEKVPVSTENNEFSYVPTNGSLYPPSETIYIRNLSEKVKIDVLKKSLEAVFSSYGTILDIVAHKNIRMKGQAFVVFDSISSAQKAIADVQAFKLFDKPMVLQFSKTKSDATVKKFGTLEEFEEHKRRRIEKKVNRKVIQVKAPQTTTTKKNVSKKVTQKQPTIPDEYLPPHKVLFLQKLPENVTADVLSAVFGRFSGFKEVRMVPGRAGIAFVEYERDEDAIVAKQGTVGMSLSGCVISVNYGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQW1</accession>
    <name>M7NQW1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NTF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874214.1">
        <property type="nucleotide sequence ID" value="XM_007876023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQW1"/>
    <dbReference type="STRING" id="1069680.M7NQW1"/>
    <dbReference type="GeneID" id="19895923"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02230"/>
    <dbReference type="eggNOG" id="KOG4353">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122448_1_1_1"/>
    <dbReference type="OMA" id="THAFTQT"/>
    <dbReference type="OrthoDB" id="25408at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="2">
        <location>
            <begin position="14"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="118" mass="13569" checksum="D74EFA9FF93EEF83" modified="2013-05-29" version="1">MSEYRNLIDVISKGAESFINIFFKCMDNNRDILHQFYRPFSTIVWNGNAFVGLSYAEFVKRLPNSHHEVQSFDCHPIISSMNQDGTCTIILVVSGSVQYGNESQLRGFSIWKDQELII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7NR05</accession>
    <name>M7NR05_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_02131</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874113.1">
        <property type="nucleotide sequence ID" value="XM_007875922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NR05"/>
    <dbReference type="STRING" id="1069680.M7NR05"/>
    <dbReference type="GeneID" id="19895824"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02131"/>
    <dbReference type="eggNOG" id="KOG0334">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_0_2_1"/>
    <dbReference type="OMA" id="FAQYVHT"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990446">
        <property type="term" value="F:U1 snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990447">
        <property type="term" value="F:U2 snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903241">
        <property type="term" value="P:U2-type prespliceosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17953">
        <property type="entry name" value="DEADc_DDX46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22474">
        <property type="entry name" value="KH-I_PRP5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23469">
        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="299"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="330"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="519"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="140"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="752"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="795"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="299"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="756"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="795"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR09546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="919" mass="103927" checksum="4F375CA831A6BB80" modified="2013-05-29" version="1">MSHQRYHSSESFSKRHRSHHSTHDHDRDSRYLKDKESNRNKEQDREQKSYTNKVSSEGGSQAKDDEKERMRIKQEKIQQFLRQRAVRMAEKEKEKENTMSTEKETKKNEQEPLVPSIGARGSVSGFEFGRTVTKMSTQAITLDDYEKKRKIPMESLGDEDNMEESSQKGSKNTENEEEVDPLDLFMQGMDEVIKRDAEGKVENHLSLDELLENKEDSEEEKEENSINDPRDILALAQKKMKKKELPNIDHSKIHYEPIRKNFYVEPHELSEMSEQEVNDYRLELDGIKIRGLNCPKPIQNWSQCGLPAHVLDVIYQLKYEKPTAIQAQAIPAIMSGRDIIGVAKTGSGKTISFLLPMFRHIKDQRPIDSLEGPIALIMTPTRELAVQIHKECKHFLKVLGLRAVCAYGGSPIKDQIAELKRGAEIVVCTPGRIIDLLGANQGRVTNLKRTSYIVLDEADRMFDLGFEPQVMKVVNNVRPDRQTVLFSATFPKQMDILSRKILQKPIEITVGARSVVASEIQQLVEVCTEDNKFVRLLELLGNLYVNDDDVRTLVFVDRQEAADSLLRDLMRRGYPCMSIHGGKDQFDRDSTIADFRAGVFPILIATSVAARGLDIKQLKLVVNYDCPNHLEDYVHRVGRTGRAGETGTAVTFITPEQDRYAADIVRALRISKANIPEDVQNLANEFIKKVKSGQEKASGSGFGGKGLDRLDKDRDLVRKLQRRAYGEESDEEVDVFDDDYEYSKMDLYDMEEPDTSFKSDSNANSNSSMVASQTNKKGNITDDILERVRKAAGSVTSRLQGQSRSGITIESGGPDSREFTATIEINDFPQKARWAVTNRTNIARIIDLTGTSITNKGNWYPPGKPVPPGETKLYILIEGETQISVDRALYELKRLLTEGTVSALESEIRSGVSGRYSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NR38</accession>
    <name>M7NR38_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02162</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874143.1">
        <property type="nucleotide sequence ID" value="XM_007875952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NR38"/>
    <dbReference type="STRING" id="1069680.M7NR38"/>
    <dbReference type="GeneID" id="19895855"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02162"/>
    <dbReference type="eggNOG" id="KOG0439">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032848_1_1_1"/>
    <dbReference type="OMA" id="GFKRPFN"/>
    <dbReference type="OrthoDB" id="264603at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033149">
        <property type="term" value="F:FFAT motif binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090158">
        <property type="term" value="P:endoplasmic reticulum membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016763">
        <property type="entry name" value="VAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809:SF6">
        <property type="entry name" value="AT11025P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019693">
        <property type="entry name" value="VAMP-associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="MSP" evidence="7">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="262" mass="29637" checksum="007E0E0EFF526D1D" modified="2013-05-29" version="1">MSVECTSQLGFHRPLTMMVKESLFICNPHEFPIIFKIKTTAPKQYCVRPNSGRIEAGKEIEVLVLFQALKEEPPLDYKCKDKFLIQSIILNDKNATDSQNMLSLFDSVAKEDIYEKKIKCVFLSPVQDSVHNISEKFSNGYDKFGSTRSSQTHDYNTDSTTKPILDPNYSLQEDSTLINKALENPESSSNLAIQLVEAKTTIKKLKDHLKESELRHRGSEAFEKKEKTAAEKIAITTTIKSVPIHVCIALCLAAFFLAYFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NR83</accession>
    <name>M7NR83_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">U3 small nucleolar ribonucleoprotein protein IMP3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">U3 small nucleolar ribonucleoprotein protein imp3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_00822</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the U3 small nucleolar ribonucleoprotein. Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of a heterotrimeric complex containing IMP3, IMP4 and MPP10.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872729.1">
        <property type="nucleotide sequence ID" value="XM_007874538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NR83"/>
    <dbReference type="STRING" id="1069680.M7NR83"/>
    <dbReference type="GeneID" id="19894520"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00822"/>
    <dbReference type="eggNOG" id="KOG4655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097281_0_0_1"/>
    <dbReference type="OMA" id="FRIKHEQ"/>
    <dbReference type="OrthoDB" id="10248812at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140691">
        <property type="term" value="F:RNA folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000006">
        <property type="entry name" value="U3 small nucleolar ribonucleoprotein IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="14">
        <location>
            <begin position="4"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="13">
        <location>
            <begin position="110"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR11233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="186" mass="22170" checksum="7E5F834D82C8433D" modified="2013-05-29" version="1">MLRKLKYHEKKLLKKHDFLNYKKDDNNHRDVNVIRRYHIQKREDYFKYNQLVGLLKKIAYKLSLLDLKDSFGDLYKKMLLEKLFDMGLLTSTSKLSDVENKLTVSAFCRRRLPIVMCRLKMCETVSTAVKYVEHGHVRIGPEVITDPAFFVTRNMEDFITWVDSSKIKRNIAKYNDKLDDFDLLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRA8</accession>
    <name>M7NRA8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01956</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873933.1">
        <property type="nucleotide sequence ID" value="XM_007875742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRA8"/>
    <dbReference type="STRING" id="1069680.M7NRA8"/>
    <dbReference type="GeneID" id="19895650"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01956"/>
    <dbReference type="eggNOG" id="KOG0864">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052718_0_0_1"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF142">
        <property type="entry name" value="RAN-BINDING PROTEIN 3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="4">
        <location>
            <begin position="198"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="67"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="342" mass="38585" checksum="4003EB1D9EB92419" modified="2013-05-29" version="1">MKNKEENNNPLNQARELFVQEAASFSELKNESKSLEENQKSVEKCPGIEEKKDNICKKRIAEDKGSNFVEKFEGKRPKKDKEKDSPEINQTSNYQSQTLSASFKSFSESSVSPFSSLKSNNPIFVNPSNQLEKKTFGSNISGPNFESLLSSSKNDIKEDVSDNKITNSLTDTYKKASDEAFGILLKQELDCRDSFDDNITKVTTFILEQEVKTGEEHEKTIYSTRARLYVVDSVTKDWKERGIGTLRVNIDETKGIIKRSRLVMRADAVYKVILNASLFKEMLIEGGNIDSSNACNLDKFLKIVALEDGKPTQFAIKVKDNTVAQQLRQHILSALPDKKITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRG2</accession>
    <name>M7NRG2_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02038</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874018.1">
        <property type="nucleotide sequence ID" value="XM_007875827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRG2"/>
    <dbReference type="STRING" id="1069680.M7NRG2"/>
    <dbReference type="GeneID" id="19895732"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02038"/>
    <dbReference type="eggNOG" id="KOG0846">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055188_5_1_1"/>
    <dbReference type="OMA" id="EPGWLVN"/>
    <dbReference type="OrthoDB" id="361383at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_uL15_bac-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934:SF11">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="113"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="50"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="237" mass="26829" checksum="681AD5B9965BB158" modified="2013-05-29" version="1">MKNIIFSSFKRFKINKIVHMFYTLRLFFSCNLNRNISFLASLTNNPLSMKKAKRVGRGPSSGKGKTCGRGHKGQKARSGNNRVKPGFEGGQTPLTRLYPKRGFVNVNSKEFSPLNLQRLQIWINNGRIDAKKPITMKHLYDSNIIHGIKSGVKLLANGKEFFNIPIEIEVSKASKEAIKRIESTGGKITCVYYNSLGLRAHLHPEKFKIIPKQAQPISRSNIQYYSDKNNRGYLASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRG6</accession>
    <name>M7NRG6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PNEG_02043</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874023.1">
        <property type="nucleotide sequence ID" value="XM_007875832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRG6"/>
    <dbReference type="STRING" id="1069680.M7NRG6"/>
    <dbReference type="GeneID" id="19895737"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02043"/>
    <dbReference type="eggNOG" id="KOG0828">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010475_1_0_1"/>
    <dbReference type="OMA" id="MLTPCHH"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd23117">
        <property type="entry name" value="RING-H2_TUL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021319">
        <property type="entry name" value="DUF2921"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF162">
        <property type="entry name" value="TRANSMEMBRANE E3 UBIQUITIN-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11145">
        <property type="entry name" value="DUF2921"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="268"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="500"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="563"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMR09862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="626" mass="72978" checksum="9B6639E5A9F29538" modified="2013-05-29" version="1">MAMKNLTLGIQANITDVDITIPDIILKKRNLLFSKGISEKENLYHNITGYIRGKWNKFFVHPNDTLIPKYAQDFIKILSYNRGLLSIVLEESIFNDSQITDATLSIQDEIGNLYKNINLKGIHFKNDGSLILTSSSHKFPSLITIPLFAFNNFTFQKSLRSITQILEQQIKQLQDSIPKNKKIQIPSDNNEYCEFVVYLQLLPNYDNKEPKLEEIEKELQTPNGLPYSLVPPILLSGIIMSPDCKFSLDFDNITGIKKEKYYADINKIAFFQNLLIIIQIYLLIKQMNETSTPSSISRISFWSIWIQASLDGYTCMIFLSASISHNSIFLSSVTTSFLSFTLVAIFGMRYLLIIHRIQQPENRTTAIERRDHSEINEETVMSNRQDYVNRNQESRTRQDQYDSHSDISTIYTQFYLFLLIIVLIFPQIMLLPTNKRKYIIYTITFMAFSFWWPQIIRNSLKGYRRPFLWSYVIGMTITRVIPIIYLFSYPKNILFIPTNLYITWGVFGWLWFQVFLLASQDFLGPRFFIPSNLLRPTYNYHPILSEDVETASSYFDSNGRTICSICIQNISLPRINRNSTNNASLILGRRSYMVTPCKHLFHTNCLERWMRVRLICPVCRHSLPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRM0</accession>
    <name>M7NRM0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3752 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872289.1">
        <property type="nucleotide sequence ID" value="XM_007874098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRM0"/>
    <dbReference type="GeneID" id="19894110"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00412"/>
    <dbReference type="eggNOG" id="ENOG502RXM1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_943721_0_0_1"/>
    <dbReference type="OrthoDB" id="73491at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022226">
        <property type="entry name" value="DUF3752"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046331">
        <property type="entry name" value="GPAM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370:SF1">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12572">
        <property type="entry name" value="DUF3752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3752" evidence="1">
        <location>
            <begin position="151"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="295" mass="34265" checksum="5B78715F3315CB3D" modified="2013-05-29" version="1">MILSDISLTSKNSSEKANINCTLDKNDESDNLTKKVLKEQSIKPYHIIGPLLPEDIPGEKEYENEDKNKGDISFFEKTGKISQILSSEEVESDEDEIGPRISDFLNFSNVKEGREQRVIEFKKIEEKRSDEISETSIKTNEKKRDDWMIVPPDASYLNSRTSVKARTFNTGKSARLGEFGVQDMNLWTESYEEKQKRLKQETIGTKIPAYQVSTEKETSNTIFDIKKQKTSFENKRPSLYDMHLKKNKEMIDDPSKRMFDREKDVLNENCMNFEKRQKLMDFAKDLSRFSSGSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRP5</accession>
    <name>M7NRP5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01710</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the epsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873674.1">
        <property type="nucleotide sequence ID" value="XM_007875483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRP5"/>
    <dbReference type="STRING" id="1069680.M7NRP5"/>
    <dbReference type="GeneID" id="19895404"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01710"/>
    <dbReference type="eggNOG" id="KOG2056">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012678_0_0_1"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180020">
        <property type="term" value="F:membrane bending activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16991">
        <property type="entry name" value="ENTH_Ent1_Ent2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000006">
        <property type="entry name" value="Clathrin interactor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF110">
        <property type="entry name" value="EPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="8">
        <location>
            <begin position="11"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="137"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="519"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="545" mass="62665" checksum="FB7BBA76CDEE1D00" modified="2013-05-29" version="1">MYTGKAAIRTVKNLKYSDVQNKVRSATSNDPWGPSGVEMNEIARMTFDPHNFIEVMDMLDRRMNDKGKNWRHVFKALTVLDYCLHSGSENTVKWAKDNIYIIKTLREFNYVSEDGKDQGSNVRIKARDITELLQDDDRLRSERKNRTHMHNRLGLQHNDNMSGSSSYKKSSYKKHSQTFDASDDDKELQRAIEESKLQSEDDKLRSLLKTKQEEEELALALQLSKEEEELRNMALLQKERGALLLEQSFQQPQQPSKLMDFFIKDTSIQQPQNIDYIQNMHLQSTNAFENQQNLNTQNIGYYQPQENYQLNHSQINYPLFQQNEHANNPYSSYIDAQTFQGDSPFDHSYLNRPQDQFKSLRVGSNNPFIQMANLSDYKPNYNTISSPLEIYSDQKSESNNTIPTAQSIFFPQHKYDASYQAKLSSILQAKNPEIDTFGNTGDLRIPSQHIACEFVNSYGMRTKTEPTISGTLNNQKSNQTLFNRRPILSAPTGVGFKNISTQENCIDLSSTFSQSTIQENNPYLSSSNHSSHYQNNPPSGSLIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRZ4</accession>
    <name>M7NRZ4_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell division control protein 48</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02056</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874037.1">
        <property type="nucleotide sequence ID" value="XM_007875846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRZ4"/>
    <dbReference type="STRING" id="1069680.M7NRZ4"/>
    <dbReference type="GeneID" id="19895750"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02056"/>
    <dbReference type="eggNOG" id="KOG0730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_12_0_1"/>
    <dbReference type="OMA" id="VWPAYPE"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19519">
        <property type="entry name" value="RecA-like_CDC48_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19528">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000004">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000001">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000003">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000048">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="7">
        <location>
            <begin position="41"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="6">
        <location>
            <begin position="141"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="253"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="526"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="798"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="817" mass="90837" checksum="4ADA1404F5376B19" modified="2013-05-29" version="1">MPEELGKGGLNNEKRANVVEKIESENKLAMSILRKKKKQNSLIVDDAVNDDNSVISLSNNTMEILQLFRGDTVLVKGKKRRDTVLIVLVDDDMEEGVARINRVVRNNLRVRLGDIITIYPCPDIKYASRISVLPLADTVEGLTGSLFEVYLKPYFVEAYRPVRKGDLFTVRGGMRQVEFKVIEIDPSEYGIVAQDTIIHCEGEPINREEEESNLADVGYDDIGGCRKKMAQIRELVELPLRHPQLFKSIGIKPPKGILLYGPPGTGKTLMARAVANETGAFFFLINGPEIMSKMAGESESNLRKAFEEAEKNSPSIIFIDEIDSIAPKREKTNGEVERRVVSQLLTLMDGMKARSNVIVMAATNRPNSIDPALRRYGRFDREIDISIPDPTGRLEILQIHTKNMKLGDDVDLEQIASETHGYVGSDIASLCSEAAMQQIREKMDLIDLEEDTIDAEVLDSLGVTMENFRFALGVSNPSALRETIIEVPNVRWEDIGGLEDVKAELKETIQYPVEHPEKFIKFGMSPSKGILFYGPPGTGKTLLAKAIANECAANFISVKGPELLSMWFGESESNIRDIFDKARAASPCVIFLDELDSIARSRGGSIGDSGGASDRVVNQLLTEMDGMTSKKNVFVIGATNRPDQIDPALMRPGRLDQLIYVPLPDMASRLSILKAQLRNSPVASNVDLSAIAKATHGFSGADLAGLTMRAAKLAIKESISYEIKREESQKEKKDEIEDIEMDDPVPEITRAHFEESMKYSRRSVLDSDLRRYEMFANQFNQNRGFSTFKFEDSVNNSRAENSSGAIFGEETGDDLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NS93</accession>
    <name>M7NS93_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00062</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871918.1">
        <property type="nucleotide sequence ID" value="XM_007873727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NS93"/>
    <dbReference type="STRING" id="1069680.M7NS93"/>
    <dbReference type="GeneID" id="19893760"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00062"/>
    <dbReference type="eggNOG" id="KOG3151">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046003_2_1_1"/>
    <dbReference type="OMA" id="HIMDGYF"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.990:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006746">
        <property type="entry name" value="26S_Psome_Rpn12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="69"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR11623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="277" mass="32000" checksum="403833820D9115B2" modified="2013-05-29" version="1">MNVLKQGLQELRNLFNTKQYIKCSELLTRLKIALSEENLLVPGAHLEVNDMILAREIFEIGAYTSLRLSDTEAFVRYTSQLQPYFSNPLLSKLPLSQHQSLLTGLWLLNLLAKNCIAEFYTSLETLPTDMIEYDKYISWVIKLEQSIMEGSYDRVKKMLIHCPSPEYEIYVNMIMDLVRNEIANCLEKAYTSLPLQNAVGLLFLSNLNEIIEFSNKKEWLIQNDRIYFPDKASESVDEMLIDDQTGSFKFNGIKSETPNLNFVQQILGYAEELEQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSA1</accession>
    <name>M7NSA1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01754</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873718.1">
        <property type="nucleotide sequence ID" value="XM_007875527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSA1"/>
    <dbReference type="STRING" id="1069680.M7NSA1"/>
    <dbReference type="GeneID" id="19895448"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01754"/>
    <dbReference type="eggNOG" id="KOG1158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_17_5_1"/>
    <dbReference type="OMA" id="LCCGGGC"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030586">
        <property type="term" value="F:[methionine synthase] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050667">
        <property type="term" value="P:homocysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000007">
        <property type="entry name" value="Methionine synthase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF84">
        <property type="entry name" value="METHIONINE SYNTHASE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfite reductase [NADPH] flavoprotein alpha-component-like FAD-binding" evidence="6">
        <location>
            <begin position="147"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidoreductase FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="421"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="64886" checksum="75A4F5AD874E86F4" modified="2013-05-29" version="1">MEKIQKQIENCKIRDQKVFSDKKSSFQSIDLKKDLQESFKTDIYSTKNDLITSQQDFLNNIKCTNCEKTNNSFSEKSIEQDPVLFSLKTDNPALFSLQLPDEAFHIQNFSGIPKLKEPFILFHETCLQEKLRGDIYLHPPSYLINHHKYYVFRSEILIARLLTSEGALKKTLHFDLDVKDYLLNKDETWSIGGTIGICVPNLKNVVDEIFELLNISKEKADEQIILETKGGRWPTMWGNACPRKIKTTRRDLLTWTVDIQSMPLKKNLLRVLMEYAKDPLDKRLLAFLCSKEGQKSFLNLCSQKCITLSHLLSAFPSSKPSFEHLLSVLTPLSPRKYSLSNDPSLSPGILQIALTILQIPHWKTGTRPGVASAYLEQIFHEYINRKKTNVKETLHKLTISIFRDHLNPFVHNAYADGSRIFIGVGVGIAPFRGFVQNRLQNLSCLENLWIIQGCRDSKLDEIYSGEWGLFNTSKNRIIVESRAGKKEHVQDEIRRKGKLIWDVVNRKDGRIYVCGPGIIFTKSIDECLIKIAMEQGGYTREDAIKKWKEFEDPSVFKYIKETW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSF0</accession>
    <name>M7NSF0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MMS19 nucleotide excision repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00115</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the MET18/MMS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871973.1">
        <property type="nucleotide sequence ID" value="XM_007873782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSF0"/>
    <dbReference type="STRING" id="1069680.M7NSF0"/>
    <dbReference type="GeneID" id="19893813"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00115"/>
    <dbReference type="eggNOG" id="KOG1967">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005943_1_0_1"/>
    <dbReference type="OMA" id="FSFMPEF"/>
    <dbReference type="OrthoDB" id="342900at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039920">
        <property type="entry name" value="MMS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024687">
        <property type="entry name" value="MMS19_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029240">
        <property type="entry name" value="MMS19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891">
        <property type="entry name" value="DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891:SF0">
        <property type="entry name" value="MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12460">
        <property type="entry name" value="MMS19_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14500">
        <property type="entry name" value="MMS19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MMS19 N-terminal" evidence="7">
        <location>
            <begin position="39"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="MMS19 C-terminal" evidence="6">
        <location>
            <begin position="548"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="MMS19 C-terminal" evidence="6">
        <location>
            <begin position="855"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR11678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="997" mass="115646" checksum="E5BA19BECA117C18" modified="2013-05-29" version="1">MDQKIDNYFSLDSKENYKELVDIISKDIDNKNIKILEFIECLGKYLTENKEFRRKKVIILLSGVIESISRKILDSQQIHVLTRFYCDCLCDQSCVKEILSGLYSLQKMDFFDDKEAVFMCGGLFKNFDSESNIQSIRYVVFQILSELVIKHQKALKKMGPEFIKGLIKIIGREKDPRNLILVFSIMNTVISEFDITSYAKDIFDLLFCYFPITFKPSINDVFGITSDDLKFWLNKCLSANDILSPYSIPLLINKYNFSSVSIKKDILDILSFCMKTYSPNVIKIYVLQIWNTLKNDLFEGTDDDFLKKSLDCLFIISKTLSKETSEISKKNSLLEFFSFISNEINDHFKEPDTKTAKNGIKILYALSSSSKYAFEILSKFCVSDLVSRFEKEDSINTKTAILELLSFILLSGLHVYGSYEKKIDEIPDDSILIQEKDRLLTISYNSLTTSSFSNKYIKAAAIRFLLTFSQIHDLLQYNELKLIVEYYNEIIIKEDSLKAEALDALVKIAEIKPNLIFEITFPNFLKLLSEESYSLTLNNLFQSQDEVILTTLSYLCVEKRLFTTLTTHLIKKFDDIIFVNDRKILYGRALMFTLLLAIRTNFTRKKLDIGSYINQLLPQLFTRVINACIDSKENIIIDSKIISIISQITNLIVRSSNFQKQKLFIADLINLFINGNSNLLFLSKNTEILKVFKPFDKNSTLYQKKTLPIFISAFAGIQKELLPLDLKLVFIKTATDLILENQLEDEQRIFLFRFISLIYNKYSDELNSDYCEIFLNEISKFSENDISKKKLMILYIFWVIKALILKTNKYGYVLLDKLINFLDDKHLGEFISYNFGIILDEDELINKENYASLQENLKSNYLVIFSYVIQYIPKQVIFPELVSIFPILLQCFSLDNCKLKASNINTLYTITLESPDLVVEHLASIIPFLLTFITKKDNSTNIQITALQCLGLFPTVLKTESIYPFKNKIIRKLTMVLDDPKKDVREEARKTKHKWHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSL9</accession>
    <name>M7NSL9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Letm1 RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_00177</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872038.1">
        <property type="nucleotide sequence ID" value="XM_007873847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSL9"/>
    <dbReference type="STRING" id="1069680.M7NSL9"/>
    <dbReference type="GeneID" id="19893875"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00177"/>
    <dbReference type="eggNOG" id="KOG1043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008958_5_2_1"/>
    <dbReference type="OMA" id="LQHYWDG"/>
    <dbReference type="OrthoDB" id="275278at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="10">
        <location>
            <begin position="219"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="448"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="469"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR11743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="485" mass="55960" checksum="9206BCAE29D3A659" modified="2013-05-29" version="1">MKYKRIGASSFQLAPDFLWVSSNIPSLTISLYARTILNRKPWIASLNNVRQHSMETVKSTYQRGSSISSQRSSLYEQVLNKEKIGQNTGKIASEAEKGFIPNVEEKLLSEINSQVNNGKNKKKTIWQKIKHEAQHYWDGTKLLGAETKISWKLALKMAAGHELTRREHRQLKRTVKDLVRLVPFSAFVLIPFAEFLLPVALKLFPNMLPSTYEADKDREKRQARLSDTRKSVSQFLRMTLQESGLPFSTTTKQREEFTEFFRKIRNGNEPPSQTDVISVSKLFRDDVTLDNLSRPQLVAICRYMNLNTFGTDPMLRYQIRHKMRQIKSDDKAIWYEGVETLSVPELQIACANRGIRTHSVSPAKLRDELQQWLDLRLKHGVPSTLLVLSNAFMYDQDNQSDRHYNALIATLSSLPDELYHETELSVRDKEATNKQRLEVIMEQEELIASESRQNEKNDCKNSIKNNGDLQEKNIKKQDLKENSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSP8</accession>
    <name>M7NSP8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Long chronological lifespan protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01545</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LCL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873492.1">
        <property type="nucleotide sequence ID" value="XM_007875301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSP8"/>
    <dbReference type="STRING" id="1069680.M7NSP8"/>
    <dbReference type="GeneID" id="19895240"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01545"/>
    <dbReference type="HOGENOM" id="CLU_142363_0_0_1"/>
    <dbReference type="OMA" id="VEESWHN"/>
    <dbReference type="OrthoDB" id="2234316at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23996">
        <property type="entry name" value="LCL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034543">
        <property type="entry name" value="LCL2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38425">
        <property type="entry name" value="LONG CHRONOLOGICAL LIFESPAN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38425:SF1">
        <property type="entry name" value="LONG CHRONOLOGICAL LIFESPAN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR10282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="114" mass="13174" checksum="67CFACF70E483C9D" modified="2013-05-29" version="1">MKRRDFILSMFIFGGAALGYFHIFDKFFQKNKEEQELLHQDWLREKFQSVSCSDQKYLCSDTLQCVNHPANCPCPFPTSQTRCSLGNGGYICVSLSEEHDPCQIVEQYRSGHVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSQ8</accession>
    <name>M7NSQ8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Chorismate synthase</fullName>
            <ecNumber evidence="3 7">4.2.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="7">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="3 7"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873370.1">
        <property type="nucleotide sequence ID" value="XM_007875179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSQ8"/>
    <dbReference type="STRING" id="1069680.M7NSQ8"/>
    <dbReference type="GeneID" id="19895127"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01430"/>
    <dbReference type="eggNOG" id="KOG4492">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034547_0_1_1"/>
    <dbReference type="OMA" id="MLSINAV"/>
    <dbReference type="OrthoDB" id="1721239at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.150.10:FF:000006">
        <property type="entry name" value="Chorismate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="entry name" value="Chorismate synthase AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003793">
        <property type="entry name" value="PRK05382.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085:SF0">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="Chorismate synthase, AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="395" mass="43113" checksum="DF2AA98AEF8B596B" modified="2013-05-29" version="1">MSTFGTLFRVTTYGESHGQSVGCIVDGVPPGLFLSEEDIQIQLRRRRPGQNTLTTQRNEQDLVHLHSGIEDGITLGTPIGMIIYNEDCQPSDYEEIKRFPRPSHADLTYLQKYGIKSSTGGGRSSSRETIGRVAAGAIAEKYLSETYKIEIVAFVSSIGKIQMEWDMNQEDNEDDIESPISQAYLSFLSTVTREQVDASLVRCPNMVTSAAMIARIERAKENQDSIGGTITCVIRNLPAGLGEPCFDKLEAKLAHAMLSIPSTKGFEVGSGFKGTQVPGSKHNDPYIMDTNNKLRTVTNNSGGIQGGISNGENVFFKVAFKSPASIGKQQFTSSYEGTNGMLFIKGRHDPNVASRAVPIVECMAALVIMDALMIQLSRQTARSLLPPIKTKISFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSW8</accession>
    <name>M7NSW8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipase/carboxylesterase/thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873418.1">
        <property type="nucleotide sequence ID" value="XM_007875227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSW8"/>
    <dbReference type="STRING" id="1069680.M7NSW8"/>
    <dbReference type="GeneID" id="19895175"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01479"/>
    <dbReference type="eggNOG" id="KOG2112">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062889_1_0_1"/>
    <dbReference type="OMA" id="NWMWGED"/>
    <dbReference type="OrthoDB" id="437457at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF67">
        <property type="entry name" value="PHOSPHOLIPASE_CARBOXYLESTERASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_5G09340)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="2">
        <location>
            <begin position="25"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="283" mass="31584" checksum="A0C8714CCDA0F05D" modified="2013-05-29" version="1">MKHNKSTQYRIPTLSDLPEPLKGLIMAPDTPISNCLILLHGLGGSHIPFARLARHLNLPETVCISLCGLKPTPLVDPSENEAGSWHWGSDLAFDQDGIVSDDADLQKAIEMLESLCKTLTDPLPSGCGFSSQAIFFLGYGQGGRLALNFTLTQSKPNSPHFNKRFGGVLSIGGIVESLDSFTHLFLNESLSTKTNEMDNKTKNEKNHVKISSSTISRLTTPILLCGGDDESRITSQIIQQLSKIFYHVEQIIWEDHEGDTMPRNRKEWYPLLEWFSRHLLHTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NT66</accession>
    <name>M7NT66_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873106.1">
        <property type="nucleotide sequence ID" value="XM_007874915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NT66"/>
    <dbReference type="STRING" id="1069680.M7NT66"/>
    <dbReference type="GeneID" id="19894887"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01190"/>
    <dbReference type="eggNOG" id="KOG2766">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039639_4_1_1"/>
    <dbReference type="OMA" id="VRYHWAQ"/>
    <dbReference type="OrthoDB" id="429955at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009262">
        <property type="entry name" value="SLC35_F1/F2/F6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052221">
        <property type="entry name" value="SLC35F_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233">
        <property type="entry name" value="DUF914-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06027">
        <property type="entry name" value="SLC35F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="43421" checksum="4104EABE9E8C3E1D" modified="2013-05-29" version="1">MPQNQQSNNKDYSHSNSKETTFLAKENISIWKKRIKYTGFHIKHFWIIFIIGQILSLMITASSIFTAKLSDYHINIPTFQTLINYILLGSIYTSFTIYLNDFKKWTKMILKDGWKYVILAFIDIEANYFVVKAYQYTNLLSCILLDSFSIITVILLSYFFLKVRYNISQILGILICFGGLITLTISDFKLNKYHNFTNIIKGDIFIIIGACLYGLSNVLQEFFLSKRPIYEVIGQLGFWGIFIDAIQISLFEKKHLKETQWSKKTIGFIFGYNIALFIFYSLSPVLFKISGALFYNMSLLTSDFWSLIIGIYLFHYSIYWLYYIAFILVILGLLTYHLFFKDESKKPWIDYNHQEINDIEVYNNYKISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NT74</accession>
    <name>M7NT74_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="3">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GTP cyclohydrolase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_01531</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873476.1">
        <property type="nucleotide sequence ID" value="XM_007875285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NT74"/>
    <dbReference type="STRING" id="1069680.M7NT74"/>
    <dbReference type="GeneID" id="19895226"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01531"/>
    <dbReference type="eggNOG" id="KOG2698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049768_3_4_1"/>
    <dbReference type="OMA" id="HFACRPQ"/>
    <dbReference type="OrthoDB" id="4966at2759"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00642">
        <property type="entry name" value="GTP_cyclohydro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.286.10:FF:000003">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1130.10:FF:000012">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006825">
        <property type="entry name" value="PRK09347.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006826">
        <property type="entry name" value="PRK09347.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109:SF7">
        <property type="entry name" value="GTP CYCLOHYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="GTP CYCLOHYDROLASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase I" evidence="13">
        <location>
            <begin position="47"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="3"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR10266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="225" mass="26037" checksum="6889EBB042C03694" modified="2013-05-29" version="1">MEKRKKENNNDQKKKSLEEFEWQTNNINKRLKESAKERKKRIKRLSNALSIVLECLGEDLAREGLKKTPERYAKAMLFFTKGYEDNISDIINGAIFTEDHNEMVIIRDIDMFSLCEHHLVPFTGKVSVGYIPNKKVIGLSKIARVVEMFSRRLQLQERLTKQIAVTLWKMLKPRGLGIIIEASHLCMIMRGVQKPGSVTITSHMLGTFREASKTRKEFLTLISKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NT96</accession>
    <name>M7NT96_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">EB1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_01219</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAPRE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873136.1">
        <property type="nucleotide sequence ID" value="XM_007874945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NT96"/>
    <dbReference type="STRING" id="1069680.M7NT96"/>
    <dbReference type="GeneID" id="19894916"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01219"/>
    <dbReference type="eggNOG" id="KOG3000">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041744_2_1_1"/>
    <dbReference type="OMA" id="ETMPMNS"/>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055028">
        <property type="term" value="C:cortical microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061673">
        <property type="term" value="C:mitotic spindle astral microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005880">
        <property type="term" value="C:nuclear microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008093">
        <property type="term" value="F:cytoskeletal anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099609">
        <property type="term" value="F:microtubule lateral binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030989">
        <property type="term" value="P:dynein-driven meiotic oscillatory nuclear movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000742">
        <property type="term" value="P:karyogamy involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000743">
        <property type="term" value="P:nuclear migration involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035372">
        <property type="term" value="P:protein localization to microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1430:FF:000005">
        <property type="entry name" value="Eb1, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000028">
        <property type="entry name" value="RP/EB family microtubule-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004953">
        <property type="entry name" value="EB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036133">
        <property type="entry name" value="EB1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027328">
        <property type="entry name" value="MAPRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10623">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03271">
        <property type="entry name" value="EB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140612">
        <property type="entry name" value="EB1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51230">
        <property type="entry name" value="EB1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="12">
        <location>
            <begin position="47"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="EB1 C-terminal" evidence="13">
        <location>
            <begin position="195"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR10507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="33900" checksum="9897AB8F38589E34" modified="2013-05-29" version="1">MLHVLYVCSIDFECVSFEGLTFSLTRQKDIFVFLLNFETLRLGAEMSESRHELVAWLNQLTNLNITKVEECGKGYVYAHVFDSIYGGVPFRKINFNCNNEYQYLQNWRVIQSIFTQHKIDKVVYVDRLIKCKFQDNLEFLQWVKKFWDQHFSGVEYNAIGRRGGKIASSSGYSAGSSGLHEQSSRKVSTVSTSSTRVSSNPSVAFLNSQIQTLQENAVGLEKERDFYFNKLRDIEILVQTAIDADPSAAQNEESLLRQIQNILYSIEEGFEVPDLNGDEINKQMDNLQIEDDDTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTA7</accession>
    <name>M7NTA7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_01565</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873516.1">
        <property type="nucleotide sequence ID" value="XM_007875325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTA7"/>
    <dbReference type="STRING" id="1069680.M7NTA7"/>
    <dbReference type="GeneID" id="19895260"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01565"/>
    <dbReference type="eggNOG" id="KOG3996">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048602_1_2_1"/>
    <dbReference type="OMA" id="WKRIMKK"/>
    <dbReference type="OrthoDB" id="4243at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF0">
        <property type="entry name" value="HOLOCYTOCHROME C-TYPE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00821">
        <property type="entry name" value="CYTO_HEME_LYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR10306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="216" mass="25282" checksum="D5535298825CD50F" modified="2013-05-29" version="1">MLEPSQASSKSSDSKNNHIRCPVSSINKNSGDLSPKKLDSFDQNLQGLSNKREISSIPKANGKEGEYWIYPSERMFFQAMRRKNWNPRINEMQFIVPIHNAVNEQVWREILSWEKGWGSEMCGGPKLVEFEGKSSKMSPKARWLKYLGYKPPFDRHDWKIDRCGKEVTYIIDFYSGKKEGDLLSFYLDVRPKLSINGAWMRLIRVFEDFFQKKKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTH3</accession>
    <name>M7NTH3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major surface glycoprotein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01106</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873021.1">
        <property type="nucleotide sequence ID" value="XM_007874830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTH3"/>
    <dbReference type="STRING" id="1069680.M7NTH3"/>
    <dbReference type="GeneID" id="19894803"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01106"/>
    <dbReference type="eggNOG" id="KOG3544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010455_0_0_1"/>
    <dbReference type="OrthoDB" id="5400168at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003330">
        <property type="entry name" value="MSG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02349">
        <property type="entry name" value="MSG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082515" description="Major surface glycoprotein 2 C-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="807"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="578"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="828"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="859"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="872"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1089" mass="124519" checksum="953395D488A3F426" modified="2013-05-29" version="1">MINKIILIVILNLIALTYGSQSVNLSIRSSQTNAVNPSFKSFIDEDIYGFILKKNYNDENKCKIKLEEYCKELKDIDPGLNKVDSKAKEICNDNDKGQKCKDLKTNITEKVNQVYDEVYKIIQKFSTYEDCDKYLPRCFFLEDSTSNILEGCYFIRYDCYIRKRLKLTNEIILQAVGDSIANYNDFKEKMKEICPILIQQGNDLVIECLEIEKSFEKLNEYINYFCNSLNINLNDNELQEKCYEKLKNCYFLKNKCEKNCNDLMVLCEKKNITYKPPEKDFNPIEPEATLLEKIDLEGFYKKMRDEGIHIGNLQTTLDDMLIFLSTTASDLEENECKNELKENCDFFKYLSPEFKELCQDNKRQKCKDILEIKNRCRKLKIMLYVNGFSTKFDNKLGKDILWNKLSTSFSERECLKFRAECFFIQGACKNNLVKGCRNLELACYKKQQEQLFIKLIESKLVEEQYKLKSKDDKLKICQKIVMENCAALVNNNIENFLKCLRPKEICLELEEIIFARSKDLEQALDQARDFPKEEDCIKLKKDCEGIAKDLGSNNVKCVTLKERCKYLEVTKELKYVFLKDKSNSLANIQNCMKTLKEKCDRLFKRETNTFAVSCALPEETCKFMVSEVKNHCNAFKNNIKKHDIVSKSRNGNQTLAEEICMLWYPYCDELMENCPDKLKKGDNGNEKGVCLQLIENCRPFLEKLKLEDELTHILKGSLGDETECKETLGKHCTEWKKEGNQTLNSLCEDAKKEELCKKFVGKIKEKCPTLENELNKEKDELKKKKDEYEKVKQEAEEFGKEAKLLLSRPGQDGQGAGSKVQDGSAPKPVGPPVQPPVPVPPAQPPTPGAPGTPGTPGGAPAPVPVPVPPQGHQDHHHEEHQHQEDQHQVERQTQLMLDLFGGHLALELYLELKEKCKGLQGDCGFKKDCPGCDAACTEIDKLCEGIKPLKVTPHHTMTLMTTEITTTTMITTTTTMITTTTTTTTTTITTATKSIHGGKITEQCTFAQTTDIWVTSTSLHTSTITSTSTITSAVTLTSMQKCKPTRCTSNLTKETETEKEEEVRSNEGMKIRIPKMIKIMLGVIVMEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTN8</accession>
    <name>M7NTN8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCAAT-binding factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873100.1">
        <property type="nucleotide sequence ID" value="XM_007874909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTN8"/>
    <dbReference type="STRING" id="1069680.M7NTN8"/>
    <dbReference type="GeneID" id="19894882"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01185"/>
    <dbReference type="eggNOG" id="KOG2154">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015945_1_0_1"/>
    <dbReference type="OMA" id="ATEYIYE"/>
    <dbReference type="OrthoDB" id="10263185at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027193">
        <property type="entry name" value="Noc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455:SF0">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="2">
        <location>
            <begin position="283"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="501" mass="58294" checksum="FC04C63A3645B81D" modified="2013-05-29" version="1">MVKNSEILELEKQVNISKKSRQIFELMELCKDSSKEISLETEYSVYKIFCGLFGLGRFCQSKNISTKSHDAEIYCWYREAYVCFVLKLLKKLSMSEFEQQGHAFVLLLGLIRSESEYGSGGFMNDQYYRVLKSVLLNKDIDASFLYYIVKEYLDEYMDLQYYFYINTYKLIKEMMSCKDENSILVEAFTANLMVFLINMKPVFLDIKKCWVSRSDSFIEKFQISKQKRVFSKCWIAALELPLKYHQYKQVLNILHSNVLPFLSKPQLLMDFLTDSYDAGGAVSLLALNGLFYLIQNHNLDYPNFYAKLYTLFDENLFHIRYRGRFIKLVDLFLSSTHLPAIIVASFIKKISRLSLSANPGGIIMIIPLVYNLLKRHPACMVLIHRTSVNSIFDDPFLDQELDPSKTRALDSSLWELFTLVDHYYPSVSTLARILQEQFTKTSYNLDDFFDYSYTNIIDTEINCKVKNPPSIEYRSANGTFVAEEGNSCIFTSLWDLSDISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTZ5</accession>
    <name>M7NTZ5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_00886</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:48097"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872797.1">
        <property type="nucleotide sequence ID" value="XM_007874606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTZ5"/>
    <dbReference type="STRING" id="1069680.M7NTZ5"/>
    <dbReference type="GeneID" id="19894584"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00886"/>
    <dbReference type="eggNOG" id="KOG1499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017375_1_2_1"/>
    <dbReference type="OMA" id="CTHTKVK"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060567">
        <property type="term" value="P:negative regulation of termination of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000034">
        <property type="entry name" value="Protein arginine N-methyltransferase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="11">
        <location>
            <begin position="154"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR10737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="331" mass="38377" checksum="2318A7221FF4FEFF" modified="2013-05-29" version="1">MEKDDLSQHDIRYYDSYSHHGIHEEMLKDEVRTLSYRDAIYQNKHLFQNKIVLDVGCGTGILSLFAANAGAKLVIGIDMSDIIDKAKEIVKINGFSDKILLIKGRMENITLPVDKVDIIVSEWMGYFLLYESMLETVLLARDLYLKEGGLIFPNKATMFIAGIEDAEYKEEKIGFWNNVYGFDFTPIQKLAMKEPLVDTVELRAVVTDPYCLLTLDLYTTKKEDLSFTKEWELKARKKDYIHAIIAWFDIEFHSSGKPVRFSTGPHARYTHWKQTIFYLNHIIDINEGQTIQGTLTNLQNEKNRRDLDIIIEYTFQETETPIHDTCSYLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M7NU43</accession>
    <name>M7NU43_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872852.1">
        <property type="nucleotide sequence ID" value="XM_007874661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NU43"/>
    <dbReference type="STRING" id="1069680.M7NU43"/>
    <dbReference type="GeneID" id="19894638"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00940"/>
    <dbReference type="eggNOG" id="KOG4365">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_687206_0_0_1"/>
    <dbReference type="OrthoDB" id="21643at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="401" mass="47993" checksum="D5A80648E721073F" modified="2013-05-29" version="1">MTEESWFRFQRESKENIFISCQLRVEEAKPSYQDLKNIENERNKLDSIFKVKSRKKWTRNLLYGSLAKNQNLIKDEMVNHETKGWFKGPYGRAISIMRFRDVITGKKKILFDPIEKINLKKLYGKIIDKSVLELTYFFDDSSGQWFNGMFDQINSERNDIKINEKLLEKSLNEEFKQEKQKNLFILNKIFHDPLIEEKLNKENESNLANFKEHIFYELQNSSKSFNKDDYINAEAFLTNESIIKDDLLNEPNSEKALKTKKSIVNLKELKSIFSSKKEVDLQNIQENNFCFFDDNSSSDDKINNENNKEANINANNIPIVNKRCFFNNYSREFPLFFPHFDNAELYALSAFSKVPSIFSQEIDNEEIEKKWIDTRKEFTRDWKRKWKDAQKRKRRFLRRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NU79</accession>
    <name>M7NU79_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycolipid transfer protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872897.1">
        <property type="nucleotide sequence ID" value="XM_007874706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NU79"/>
    <dbReference type="STRING" id="1069680.M7NU79"/>
    <dbReference type="GeneID" id="19894681"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00983"/>
    <dbReference type="eggNOG" id="KOG3221">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079400_0_0_1"/>
    <dbReference type="OMA" id="EMHGAEW"/>
    <dbReference type="OrthoDB" id="205255at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000001">
        <property type="entry name" value="Pleckstrin domain-containing family A member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="202" mass="23492" checksum="0C639B5BA033CBB6" modified="2013-05-29" version="1">MSLVENNGNFRIIKMSFTDISVDESGISASDFLLASKSFVDVFDLFDSRIFSVIRNDINGNLKKIRDYLQKHPSHSKTLESLVRSEALQKKRVATEGLLWLVRGFIFMSNALHRNMENEKEELSVSFTKAYEITLKRHHSIFIRPIFTMAMKYCPSRNDFYSKLSNDQAKLRTFLYDWLSGLDKIIFSLENFYENGQYAKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M7NU83</accession>
    <name>M7NU83_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872902.1">
        <property type="nucleotide sequence ID" value="XM_007874711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NU83"/>
    <dbReference type="STRING" id="1069680.M7NU83"/>
    <dbReference type="GeneID" id="19894686"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00988"/>
    <dbReference type="HOGENOM" id="CLU_122989_0_1_1"/>
    <dbReference type="OrthoDB" id="274752at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019711">
        <property type="entry name" value="ATP_synth_F0_suH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10775">
        <property type="entry name" value="ATP_sub_h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="114" mass="13498" checksum="39AEBD21340A42A2" modified="2013-05-29" version="1">MYNPTKILRYITFAKPRIRMFIRPSYGQYQDIVKELYLRELKNCKPFVIKSNDSEGQVKAWKLPDAPKVPEIDINIDEELKVYEKEVETETSVLSDAKDPLDELFEKEEESMNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUN7</accession>
    <name>M7NUN7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00948</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">The mitochondrial prohibitin complex consists of two subunits (phb1 and phb2). The subunits assemble into a membrane-associated ring-shaped supercomplex of approximately 1 mDa.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872861.1">
        <property type="nucleotide sequence ID" value="XM_007874670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUN7"/>
    <dbReference type="STRING" id="1069680.M7NUN7"/>
    <dbReference type="GeneID" id="19894646"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00948"/>
    <dbReference type="eggNOG" id="KOG3090">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047969_0_2_1"/>
    <dbReference type="OMA" id="NEGTHFQ"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140580">
        <property type="term" value="F:mitochondrion autophagosome adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF1">
        <property type="entry name" value="PROHIBITIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="8">
        <location>
            <begin position="53"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00065366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="305" mass="33679" checksum="5C0989B79DAA1760" modified="2013-05-29" version="1">MNQAGRQTFNQMAAMLRSRTTNNGQTTGGGNSAIIGAGLVIGLAGLGMLINLSLYNVDGGHRAIKYSRISGVSPKIYSEGTHFFIPWIETPYIYDVRAKPRNIASLTGTKDLQMVNITCRVLSRPNVAALPTIYRTLGSDYDERVLPSIVNEVLKSVVAQFNASQLITQREKVSKLVRESLVRRADIFNIKLDDVSLTHVQFSPEFTAAVEAKQVAQQETQKAAYLVDRARQEKQGAIVRAQGEAKSAELIGEAIKKSKGFLELRKIEAAREISRILSEGNNRIFLNAENLMLNVAEQKDETVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVG6</accession>
    <name>M7NVG6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CLP1</name>
        <name evidence="12" type="ORF">PNEG_00297</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a pre-mRNA cleavage factor complex. Interacts directly with PCF11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Clp1 family. Clp1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872169.1">
        <property type="nucleotide sequence ID" value="XM_007873978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVG6"/>
    <dbReference type="STRING" id="1069680.M7NVG6"/>
    <dbReference type="GeneID" id="19893995"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00297"/>
    <dbReference type="eggNOG" id="KOG2749">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018195_3_1_1"/>
    <dbReference type="OMA" id="VQYVNCH"/>
    <dbReference type="OrthoDB" id="258143at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.330:FF:000002">
        <property type="entry name" value="Protein CLP1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1030:FF:000001">
        <property type="entry name" value="Protein CLP1 homolog 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.330">
        <property type="entry name" value="Pre-mRNA cleavage complex subunit Clp1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03035">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028606">
        <property type="entry name" value="Clp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010655">
        <property type="entry name" value="Clp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038238">
        <property type="entry name" value="Clp1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF6">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06807">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 N-terminal" evidence="10">
        <location>
            <begin position="21"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="11">
        <location>
            <begin position="124"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 C-terminal" evidence="9">
        <location>
            <begin position="330"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="127"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR11267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="445" mass="49589" checksum="EB5DEED1391BA747" modified="2013-05-29" version="1">MYLSKVSGLNTISEEVMTWSIQPGQEFRFEVEFDSRIEIEIKSGTAEIFGTELTIGPVYTFSGVKLALFTWRGCVIDVKGTPSVHYIADETPMLAYMNLHFAIENLRTEAMKKDEEGPRVLLVGPEDSGKTSLVRILSGYALKQKRSPILVNLDTQEDIGSIPGSVSITLISGILDIENTFGSSLTTGPSQYPSLVTLSYYYGYDFPTHNLKFYKSLISRLGIVCASKMSEIKDVKYSGCIIDTSGIIDQSKGYDIIHNIISDFSVNVLIVLGSERLYSDMARKYDNKKGMHVVKLPKSGGCVNREKSFIEKAQHSAVRKYFYGDFRTILSPYSIIYDFDSLIVYRVEEETFTHSSALPIGHDISSQKLQMIKINVFSILQNSVLAVSHANINDSIDTILESPVAGYIYVSDVDDNKKKLTILSPLPGKLPSSVLIMGSFKWQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWV5</accession>
    <name>M7NWV5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_00080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871936.1">
        <property type="nucleotide sequence ID" value="XM_007873745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWV5"/>
    <dbReference type="STRING" id="1069680.M7NWV5"/>
    <dbReference type="GeneID" id="19893778"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00080"/>
    <dbReference type="eggNOG" id="KOG3452">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140672_1_0_1"/>
    <dbReference type="OMA" id="NKGHKTE"/>
    <dbReference type="OrthoDB" id="9616667at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1760:FF:000003">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1760">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_eL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10114">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01190">
        <property type="entry name" value="RIBOSOMAL_L36E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR11641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="105" mass="12166" checksum="60FAF4E58AEC8F7B" modified="2013-05-29" version="1">MTKEERTGLAVGLNRGYKTTFRQPPPRISHRKGCLSKRVSFIRNIIREVAGFAPYERRIIELLRNSKDKRARKLAKRRLGTFGRAKKKIEELTHLIAETRKAAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M7P2W0</accession>
    <name>M7P2W0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UV excision repair protein RAD23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_03366</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RAD23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875448.1">
        <property type="nucleotide sequence ID" value="XM_007877257.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P2W0"/>
    <dbReference type="STRING" id="1069680.M7P2W0"/>
    <dbReference type="GeneID" id="19897053"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03366"/>
    <dbReference type="eggNOG" id="KOG0011">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040364_0_0_1"/>
    <dbReference type="OMA" id="PHMLEPI"/>
    <dbReference type="OrthoDB" id="419317at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120125">
        <property type="term" value="C:PNGase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14281">
        <property type="entry name" value="UBA2_Rad23_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01805">
        <property type="entry name" value="Ubl_Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000254">
        <property type="entry name" value="UV excision repair protein Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000002">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000003">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.540">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004806">
        <property type="entry name" value="Rad23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015360">
        <property type="entry name" value="XPC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036353">
        <property type="entry name" value="XPC-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00601">
        <property type="entry name" value="rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621:SF0">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09280">
        <property type="entry name" value="XPC-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01839">
        <property type="entry name" value="RAD23PROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101238">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="129"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="318"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="178"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="179"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="368" mass="40835" checksum="85D50708C16DB1FC" modified="2013-05-29" version="1">MKLTFKNLNQQKFVIEDVDPMNTILQVKEKIQEVQGHDSKCQKLVYSGKILADDKTVESYNIKEKDFIVCMVQKPKQVASSSVATESNVSTESIQDSESGKIKTMTSSSEAPTLSSGVFSDPNSLVIGQLRDTAVENMVEMGYGRTEVENAMRAAFNNPDRAVEYLLTGIPEHLSQELSQHVSLPQPVSPSQQTLQTQQVPQPTSVPTSNRSQNLFELAAQVSQQGRERLNSGSGNSLGGSGSTESLAFLRNNPQFQMLRRLIQTQPHMLESVLQQLAQGNLQLATLINQNSEAFLQLLSEEIEGEDTTLTPNMIQLTEEERQAIERLEALGFSRGTVVQAYFACDKNEEMTANYLFEHGHESDEEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7P377</accession>
    <name>M7P377_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrogen permease regulator 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Required for meiotic nuclear division protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_03431</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NPR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875518.1">
        <property type="nucleotide sequence ID" value="XM_007877327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P377"/>
    <dbReference type="STRING" id="1069680.M7P377"/>
    <dbReference type="GeneID" id="19897118"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03431"/>
    <dbReference type="eggNOG" id="KOG3830">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014314_1_0_1"/>
    <dbReference type="OMA" id="CNLAFRY"/>
    <dbReference type="OrthoDB" id="18648at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056603">
        <property type="entry name" value="HTH_NPRL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005365">
        <property type="entry name" value="Npr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153">
        <property type="entry name" value="CGTHBA PROTEIN -14 GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153:SF5">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24064">
        <property type="entry name" value="HTH_NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03666">
        <property type="entry name" value="NPR3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082600" description="Nitrogen permease regulator 3" evidence="3">
        <location>
            <begin position="22"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="GATOR1 complex protein NPRL3 C-terminal HTH" evidence="4">
        <location>
            <begin position="530"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="596" mass="67920" checksum="15CEC338922754BF" modified="2013-05-29" version="1">MTVPSHLVAVLLVINSFSGSSLVFHFPPCPDADQLLTNSLQDIDVLDGLSSNETESLEEESFVASELSDGLGEECQLEDTDKDHIRRHPWDNILGFNSDFLADLLTPCKTHCGKKFELWVDELVFLGLPVHIRSDGTWSKQANLLRYCDLSHGEASNVFDLEISGVNESVEDCIEPSQHQMTLFHIVMAMKLSLTQNYHAKINEMYTNVVTKLAMALNYEQAKTNYVWSQSEIILQMREKAVNDGISFNALWADILFKSSLASALATVYNAISVSGIAHLTINNSFDLSIFIPTPIITSSIPTDVSESNCFLTSVDIYDEDMDYNDPFLTPHSSLLLLDDIESVLQNIPADANPSLSLFVKNIRPTQTLLKLSQQINIPLKTIHVLAEHLIYWRRAIPIPPINMRNIYFVSPAANMAKLKYQESMFRMLFPTIPSLSTILEQLSKELHPFSFYIPSKSCRGIYLNVLTWLIRYGWVCQLKTFIWIRVSKEIKEVVLNKQKRGHISFIDSTSFTPIDDLTDSIIREPHQASKLERAWIEEIISRKPLKYAILFNRIIKYFNGKNALEKISSLEGIPRKDIREVLQVFENNLEKTYFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3H4</accession>
    <name>M7P3H4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">UDP-glucose:glycoprotein glucosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_03225</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875288.1">
        <property type="nucleotide sequence ID" value="XM_007877097.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7P3H4"/>
    <dbReference type="GeneID" id="19896912"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03225"/>
    <dbReference type="eggNOG" id="KOG1879">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RQTKTRF"/>
    <dbReference type="OrthoDB" id="27683at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003980">
        <property type="term" value="F:UDP-glucose:glycoprotein glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06432">
        <property type="entry name" value="GT8_HUGT1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000065">
        <property type="entry name" value="UDP-glucose:glycoprotein glucosyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040497">
        <property type="entry name" value="Glyco_transf_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009448">
        <property type="entry name" value="UDP-g_GGtrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040693">
        <property type="entry name" value="UGGT_TRXL_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040694">
        <property type="entry name" value="UGGT_TRXL_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040692">
        <property type="entry name" value="UGGT_TRXL_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040525">
        <property type="entry name" value="UGGT_TRXL_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226">
        <property type="entry name" value="UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226:SF0">
        <property type="entry name" value="UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18404">
        <property type="entry name" value="Glyco_transf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18400">
        <property type="entry name" value="Thioredoxin_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18401">
        <property type="entry name" value="Thioredoxin_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18402">
        <property type="entry name" value="Thioredoxin_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18403">
        <property type="entry name" value="Thioredoxin_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06427">
        <property type="entry name" value="UDP-g_GGTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="9">
        <location>
            <begin position="41"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="10">
        <location>
            <begin position="288"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="11">
        <location>
            <begin position="422"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="UDP-glucose:glycoprotein glucosyltransferase thioredoxin-like" evidence="12">
        <location>
            <begin position="696"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosyltransferase 24 catalytic" evidence="13">
        <location>
            <begin position="1214"/>
            <end position="1480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR08385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1529" mass="179770" checksum="53A4AA1CAE7F2833" modified="2013-05-29" version="1">MKLNIFRKAWCIIFIYFLGIFFQLCLGSPVINAYLTSSFKAPPFINIFLETVSTYGETYFFELLDIISKIRNVTLTELNLDNYNYLRKIVYDNEIIKDNISLSLLDYELGLQLLAPRIESYYHYYNYTVIPEMMNKNFILECRNWILFNGQQYCDLEEFLKAKDCRYEEIESVVLLPFDHIFDTHKNYDSPVAVLYADLDSDDYKTYHSFLFAEAKAGNLKYVFRYKPGNSGSHLLYLNGYGVQVSLKKTDYLVIDDRNIVDDLNEKTFMGNHNLNVDSDDLLSDIQNDEIKPLTNAELKRLGFSIVQFVNYSKTPLETLNSVLQDLPKYASYLSSIKVTRNLMEKLELNHQYIDPGMMLFSINGVEIDPSKINGFSLSKYLRNVYDFVMSLQKLGLSAKEAKFFVNESIYNIFNKFFDNRFDFRDKYENSMAILWLNDIENDPNYSHFSNDIYKYFDDVPFQQLHMVRRNLHHIIIFLDFSGKVDFLLLRTMLLLIRSSYPIRIGVVPIWDDSEDMFMVKLFYLLYDIYGINVAFEYLSYIDSGTRKNRNVLYRNYKIISSKYSFGKNIQYLDIDEIMKFKKLNKYVLKTKEWVLRLNIKNDNYIIVNGKFVEKKNWQYSILYIFPNDVNIIRKKIIEGSFTNNANILDYLLEDAIFTRKFYMYPTNKLIKSQNLIDFIKSYENMEFSSINENLNTEQSIWLIADFDTKKGIKYLKSALKYIIKHPYTSLRFLHNPRVNNKGEFDHFSSFLFLLKERDIDVAHPTLNYVRKIFNNYDSGGIDKKIEYPHFILNTYNSTQLALSSVKARLYWKKIGNLLNKFGFLPGEFGLLINGYIVGPMSEFDDFLLDDFESLGNFCNLSMVSKLKVIVNELSIKNSEKLKIFFPLLSSVILSYLVLEKHDDFGYSSQDKRSNLQNFFRELSPSFAYGDENDCLFNVKAILDPLNEISQKLVSILKVLKQMESVCLKVYLNPLREVTDLSINRFYRYVLHSSLKFDSNGNLIYPNAVFEELPKLHLYTVDYDILESWIVTQKESIYDLDNLLLQDLSSKKISKVRIVYELKHILIQGHAEDITLKNVPAGIQLALKTKNNSFVSDTIVMNNYGYLQFRANPGIFKIDMIKSHSSIFKISKISEKFESNDNKFSKEIILDSFEGLTIFPKLVRNPGKENVSIFEVKDLDSDNFTPNTVLNSTNSQQTDEFKLNSFMQKPYAEINIFSIASGHLYERFLYIMTLSVLKHTKHTVKFWFIENFLSSSFKNFLPYVANEFGFQYELITYRWPHWLRPQKEKQRQIWGYKILFLDVLFPLDLDNIIFIDADQIVRTDLKELVDMDLKGAPYGYTPMCDSREEMEGYRFWKKGYWESYLNGKPYHISALYVVDLKRFREIAAGDLLRQHYQTLSEDPGSLANLDQDLPNNLQHLVPIFSLPQNWLWCETWCSDETLKDAKTIDLCNNPMTKESKLKRARRQIPEWNKYDKTIADLIARVLEQRKTNESGEYVVDNIAIPVDMMQNIQFNFDEKNKKKDTHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3P9</accession>
    <name>M7P3P9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875383.1">
        <property type="nucleotide sequence ID" value="XM_007877192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P3P9"/>
    <dbReference type="STRING" id="1069680.M7P3P9"/>
    <dbReference type="GeneID" id="19896994"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03307"/>
    <dbReference type="eggNOG" id="ENOG502QQUZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009044_0_0_1"/>
    <dbReference type="OMA" id="GRHFWAQ"/>
    <dbReference type="OrthoDB" id="66409at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052809">
        <property type="entry name" value="Actin_polarity_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012860">
        <property type="entry name" value="Afi1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245:SF1">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07792">
        <property type="entry name" value="Afi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08616">
        <property type="entry name" value="SPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="1">
        <location>
            <begin position="7"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="602" mass="69607" checksum="33AD7315F6F7D4D2" modified="2013-05-29" version="1">MPYHHVDYILVAEFDIDQGPTISQQYPHTIGSDTKLLAELMLPDQAHMRSEDWTIFFLHRDTNTLKKNHNDLHEVLENQENSEPKLMYVLNLVNTKHDPDAKRGALVKAMAICTRHSFLHIYKPILLLALKKYLEHPKKTTLEHIFNSVNSMDLKMMPKLNFWERIILGNNDYKTIYHEKFPNTNTKESIQDCHEYETSIVYLGVQIPVKIPLDILPEAVGDFSLINLFQAFPQLPTKSFPLHAHLTTIGSHTHPIIVLMNALLTQKRIVFLGHGQSAGDVAKYVLASSAMASGLGVLRGFLERTFPYTDLSKIDYLLTISGYIAGVTNPTFERHPEWWDILCDIDTGKIKISSCISPANIPSYLGDFFCDYANEYQRNDMDTIFIDEMKNIISCKYGEYSVRSKWRDWVLRFTKMASTYETLVYGFSRLSNPNAKNFIIPGTGWVWQNEAQKMRDLYLNMPRFEGWRNTTSYEYYIEDLIVFNNIPIEKKFCLQHQLNRLKILRNISYEDAEAIYITLNDNVRTIDELSQLLCYLPRLQGGLTPIAAGLFHPNPKVQFAVAELLERLDSHIAGRHFINDLNKFQKLAFSRILSKKSKLRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3R4</accession>
    <name>M7P3R4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="2 12">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_03325</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 12">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="2 12"/>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875402.1">
        <property type="nucleotide sequence ID" value="XM_007877211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P3R4"/>
    <dbReference type="STRING" id="1069680.M7P3R4"/>
    <dbReference type="GeneID" id="19897012"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03325"/>
    <dbReference type="eggNOG" id="KOG1112">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000404_1_2_1"/>
    <dbReference type="OMA" id="YTMNFIR"/>
    <dbReference type="OrthoDB" id="3000483at2759"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051063">
        <property type="term" value="F:CDP reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046704">
        <property type="term" value="P:CDP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006240">
        <property type="term" value="P:dCDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01679">
        <property type="entry name" value="RNR_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.70.20:FF:000001">
        <property type="entry name" value="Ribonucleoside-diphosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573:SF6">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="R1 subunit of ribonucleotide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="13">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR08500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="844" mass="95730" checksum="CA26AEA146936B20" modified="2013-05-29" version="1">MFVYKRDGRKERVAFDKITARVSRLCYGLDMEHVDAASITMKVISGVYQGVTTIELDNLAAETAAYMTTKHPDYAILAARIAISNLHKQTKKTFSHVISDLYHYVNPKNNKPSPMISLKTYETVMKHANELDSAIIYDRDFTYNYFGFKTLERSYLLRIDGRVAERPQHMIMRVAVGIHGDDVEKAIETYNLMSAKYMTHASPTLFNAGTPNPQLSSCFLVTMKEDSIEGIYDTLKTCAMISKTAGGIGLNVHCIRATGSYISGTNGTSNGIIPMLRVFNNTARYVDQGGNKRPGAFAIYIEPWHADIFGFLDLRKNHGKEEVRARDLFYGLWIPDLFMKRVEANQDWSLFCPNEAPGLDDVYGTEFDALYERYEQEKRATRVVKAQKLWYAILESQIETGNPFMLYKDACNRKSNQKNLGTIKCSNLCTEIIEYSSPDEVAVCNIASVALPTFVDKNTYDFQKLHDVTKVVARNLNKIIDVNYYPVEEARRSNKRHRPIGIGVQGLADAFLALRMPFDSPQARELNIKIFETIYHAALEASCEMAQEEGPYETYEGSPASQGILQYDMWNVIPTDLWDWEKLKSNIAQYGLRNSLLVAPMPTASTSQILGFNECFEPYTSNIYSRRVLAGEFQVVNPWLLKDLVDLGLWNDNMRNRIIANNGSIQNIPNIPPDIKALYKTVWELSQKTIIDYAADRGAFIDQSQSLNIHICDPSFGKITGMHFWGWRKGLKTGMYYLRTQAASAPIQFTVDRKALEEVDETTSKKLSSTLKHAANVNPLVESLEKETRSEDIASNGQNIKKIDKLHKENIKMKQYEESENDIYSERTISCSIQNPESCEMCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3Y7</accession>
    <name>M7P3Y7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromatin modification-related protein EAF3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Chromatin modification-related protein eaf3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_03052</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MRG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875107.1">
        <property type="nucleotide sequence ID" value="XM_007876916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P3Y7"/>
    <dbReference type="STRING" id="1069680.M7P3Y7"/>
    <dbReference type="GeneID" id="19896739"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03052"/>
    <dbReference type="eggNOG" id="KOG3001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039566_1_1_1"/>
    <dbReference type="OMA" id="GLQTYFD"/>
    <dbReference type="OrthoDB" id="124855at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990453">
        <property type="term" value="C:nucleosome disassembly/reassembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140003">
        <property type="term" value="F:histone H3K36me3 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060195">
        <property type="term" value="P:negative regulation of antisense RNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030174">
        <property type="term" value="P:regulation of DNA-templated DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043487">
        <property type="term" value="P:regulation of RNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18983">
        <property type="entry name" value="CBD_MSL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.30:FF:000004">
        <property type="entry name" value="Putative Chromatin modification-related protein eaf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053820">
        <property type="entry name" value="MSL3_chromo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22732">
        <property type="entry name" value="MSL3_chromo-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038133">
        <property type="entry name" value="HAT_Nua4_EAF3/MRG15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="14">
        <location>
            <begin position="19"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="84"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00057322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR08575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="303" mass="35213" checksum="B601E3119AD21E8C" modified="2013-05-29" version="1">MVSAFKPDERVLCFHGPLLYEAKVLSAELREPEDAGENAEKEPHLRVHYKGWKSTWDEWVPEDRALKWTEENLATQKELQMAALAAQKKTGRRGSGRSSELTEGGPPHPRGQKRSRDTDLEKEEDFTAKPEINIPIPDTLKAQLVDDWENITKNQQLVSLPRSPTVTEILQNYKNSILAFQKKRFTDLDTDIFEEVVSGIKLYFDRCLGNILLYRFERQQYSDIRKTAKNKEMSDIYGAEHLLRLFVTLPELIAHTNMDYQSIQILKNYIKDFLKFLVKNQAEYFLKIYENASPNYQSLVRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7P4Q3</accession>
    <name>M7P4Q3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875010.1">
        <property type="nucleotide sequence ID" value="XM_007876819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P4Q3"/>
    <dbReference type="STRING" id="1069680.M7P4Q3"/>
    <dbReference type="GeneID" id="19896652"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02965"/>
    <dbReference type="eggNOG" id="KOG0929">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_295457_0_0_1"/>
    <dbReference type="OMA" id="TRMLCSK"/>
    <dbReference type="OrthoDB" id="2157641at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF373">
        <property type="entry name" value="PH AND SEC7 DOMAIN-CONTAINING PROTEIN C11E3.11C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="310"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1024" mass="116227" checksum="3913E9E81B161917" modified="2013-05-29" version="1">METYSVSAVPLKKTGFLHERIIDINDSPLFSQSNPYFSSKGQYKKNKDNILLKTNSSTKTNFLTKSPPKFLSRSISRTSISKCIENSSNSNSLAQSINGSPKHGLLSLFTSKKNENSNSEKPHSDIKNIKTRAVLKKSLISNRKNAENHNSCKNTPKSSAKLSIPKSNSSVLPLTSSLNVKNRDSKLLNKHSSFLDNNSSWILSKNVNAMKNLKLQEVYHSSLKEDSSGSLTLKENISNFSSTTLNETNSHSFTKDKQNNMIYSYSEDPGTNVSQDLRQSVTDYSELSFVSARDVFDISKNSFGDISNREIKDSLTKSDNTSYRDVDDFIRDESLKYNASIIGKSIFYGKETYVSKVKAASWLGDCMELNSQARTLYMNQFDWSGLDILTALRHLCSKLIMKAETQQMDRILESFSKRWHECNISSNLTPDIVHAIAYSLLLLNTDLHVADLTHGQKMTKNQFVENTLSTIFSSKPKPNFDLYGFFGLSLMGSPVSSKHTMSSDLVLSDQLSGTTKSNLNTSRNFSNKFLVNKASNISLNEILSDSVYFEVKAMLKEMYTSIKNFNIVQPVLNDSQFYDTQSNSSLFNTTKYSNDFYLMSLNHVSSFSCKSISETTREKHGARKFKIKNWTNRKKTLSRIYYDNFHSSISSNINDWSSGNRSSNFPVIENRSVCSFNSSCYSTNTYDCQFSTIGFAGTLNTIIKKVPTCLSNTFSHNYDTNEENELALSGPPWTKEGILKHKHYLENFKKAKHRTWVECFVVLEKGRLTMFQFNNNKFSEKKGILGGGNWIENAHIIGSFVLLQTLASSLPSPGYSPTRPYVWVLTLPNGCVHFFQAGTEELLNEWVYTANYWAARFSKEPLLGGVSNVEYGWGECLKEMNNRKGTKNNENSLKNYNPIKTECSYLKLPGDRAIIKTWNTPQVSLFSNSLKEEEQVKKLRKYITILENDVQKHNAYRPQILQAFSPRHPNLAKALLNWEKKSQYLLREIVKYKTYLETLSRALVLKEERLSRNNTTGSNCNTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7P4R4</accession>
    <name>M7P4R4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 56</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02978</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for 60S ribosomal subunit synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875025.1">
        <property type="nucleotide sequence ID" value="XM_007876834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P4R4"/>
    <dbReference type="STRING" id="1069680.M7P4R4"/>
    <dbReference type="GeneID" id="19896665"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02978"/>
    <dbReference type="eggNOG" id="KOG2573">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015495_4_0_1"/>
    <dbReference type="OMA" id="PDNYMFA"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000001">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000002">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="8">
        <location>
            <begin position="295"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="442"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="442"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="476"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="516"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="526" mass="60153" checksum="30DF0E5AF8DB2B54" modified="2013-05-29" version="1">MVDQILAEFATGYALFEVIQAEAIGAKLREVQEASQDLSKFGKFIKLRSFLPYRDAANALENIKDISEGLMNENLKTFLEMNLPKFGKKGRIVLGVSDKNLAGDIRARFKGIECDTSEVTQDLLRGIRFHSEKLLKQLQPGDLEKAQLGLGHSYSRAKVKFNVNKVDNHIINAIAIMDQLDKGINTFSMRIREWYGWHMPELVKFVNDNYQYAKLAIYIGNKTSLSQDNLQDIAAIVNNDPITAQNIINTARISMGQDMSTVDMENIVIFAQKVVDLVDYRKKLYTYLVNKMNTIAPNLTKLIGEVIGARLISHAGSLTNLSKYPASTVQILGAEKALFRALKTKGNTPKYGIIYHSSFIGRAEQRNKGRISRFLANKCAIASRIDNFTEIPTTRFGEILKKQVEERLSFYESGTALTKNSIAMKQAINLVLSENISQNISEKDKRNKEKTKEKKKEKDKKKEKDKKKEKDKKKEKKIEKQEKEKDKVKKEKKKQKKEKESKEKRSREDEEEIKSSKKRKKENKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6E8</accession>
    <name>M7P6E8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02387</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874393.1">
        <property type="nucleotide sequence ID" value="XM_007876202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P6E8"/>
    <dbReference type="STRING" id="1069680.M7P6E8"/>
    <dbReference type="GeneID" id="19896080"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02387"/>
    <dbReference type="eggNOG" id="KOG3362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106918_1_0_1"/>
    <dbReference type="OMA" id="CGMKYCS"/>
    <dbReference type="OrthoDB" id="74807at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21437">
        <property type="entry name" value="zf-HIT_ZNHIT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039723">
        <property type="entry name" value="Vps71/ZNHIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13093">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="5">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="146" mass="16825" checksum="EF635CCC42963C24" modified="2013-05-29" version="1">MPFVSSVENSILNRKKRPTDRTKIVIIDPSVQIKHINRHLVELERDNYNDVKIELTKNEEIRTKKSNANVRKILTSRKTFAMHLDEAGANTGYHLAAVGPSNRPPIRLCIICGYWGNYRCNKCGERYCSKSCEIAHLETRCMKTYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6X4</accession>
    <name>M7P6X4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA N(3)-methylcytidine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02223</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874207.1">
        <property type="nucleotide sequence ID" value="XM_007876016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P6X4"/>
    <dbReference type="STRING" id="1069680.M7P6X4"/>
    <dbReference type="GeneID" id="19895916"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02223"/>
    <dbReference type="eggNOG" id="KOG2361">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029724_1_1_1"/>
    <dbReference type="OMA" id="PDRMQSV"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052735">
        <property type="term" value="F:tRNA (cytidine-3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106217">
        <property type="term" value="P:tRNA C3-cytosine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF11">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="5">
        <location>
            <begin position="137"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="317" mass="37848" checksum="7D02B246FEE6D15B" modified="2013-05-29" version="1">MVEDCIEECVSEFFQKLYEKDNQITTFSVDDMNIINQVKKPFRSRYLTDSNKVFSYNAWDDVEWDDEQKKIAIEKINKQMSSPVIDKEKYMNNQSLFWDKFYQNHKTHFFKNRKWLFHEFPQIFDCICSYSGKKYILEIGCGVGNTMFPILLQNKNPFLVIHGVDYSRKAIEILERSEFFSGNNIRASVWDMANLNGEFPEGATNVDIVILIFAFSSLSPSQWNIAMLKPGGIILFRDYGRWDMTQLRFKKERFLEDNFYIRGDGTRVYFFSHEQIPEIFGKLFKIERNELDKRLLVNRATMQKMYRIWIYGVFKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7P7E4</accession>
    <name>M7P7E4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA ligase 1</fullName>
            <ecNumber evidence="3">6.5.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">DNA ligase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PNEG_01944</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873921.1">
        <property type="nucleotide sequence ID" value="XM_007875730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P7E4"/>
    <dbReference type="STRING" id="1069680.M7P7E4"/>
    <dbReference type="GeneID" id="19895638"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01944"/>
    <dbReference type="eggNOG" id="KOG0967">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005138_4_2_1"/>
    <dbReference type="OMA" id="WIKYKRD"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903461">
        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000001">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000016">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="18">
        <location>
            <begin position="449"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMR09760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="721" mass="82012" checksum="C9E1E99CFB5555E7" modified="2013-05-29" version="1">MVKSSFIKKSILDSFFNTNSKNSEKKDESKDENNSLVKKRKIFKELSGNKENKGDSESIFPNTSESCSISCVLEDKNVEKSEFNQFLSENEKNSLQKEPILYSFLCETFEKIESTSKRLDILSYTIDFLFSVLKKSPENLLQCVYLMINRISSDYQGLELGIGESLLIKAIGESMGRSITKIKEDYKEYGDLGLVAMNSRNNQPTMFKFSVLTVPNVFKSLKEIATTSGKDSQVKKLGIIKKLLSSANGNETKFIIRSLEGKLRIGLAEKTVLISLAHAVKKMEIERDNSIVTPSCLTNAENIIKQVFSQVPSYDIIVPTLLTHGIQDLSKYCKLTSGIPLKPMLAKPTKTISEVLDRFENHSFTCEYKYDGERTQIHLTNNGEIKIFSRNSENISDKYPDIIEIIPKVTKDGVTSFVLDCESVAWDRIKKMIQPFQILSTRKKKEVNVESIKVNICIFAFDILYLNGEPLIFKPLNERRDILFQSFKPLEGTFSFVQFNDAKSLEDIQMFLEKSIQDSCEGLMIKMLDGEESAYEPSKRSRNWLKIKKDYMSNIGDSLDLVVLGGFYGKGKRTNTYGAYLLGCYKSDKGVYETICKLGTGFSDEILESYASFFNNHILEHKKSYYHHSAKGEQPDVWFEPVAVWEVLAADLSISPKYLAAVGMVDPNKGISLRFPRYIRARNDKTPEQATTSQQVAQMYQAQISRLKSTFKHDPDDDYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M7P7H9</accession>
    <name>M7P7H9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription factor TFIIIC triple barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873960.1">
        <property type="nucleotide sequence ID" value="XM_007875769.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P7H9"/>
    <dbReference type="STRING" id="1069680.M7P7H9"/>
    <dbReference type="GeneID" id="19895675"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01981"/>
    <dbReference type="HOGENOM" id="CLU_2484262_0_0_1"/>
    <dbReference type="OrthoDB" id="1877767at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019481">
        <property type="entry name" value="TFIIIC_triple_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10419">
        <property type="entry name" value="TFIIIC_sub6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIC triple barrel" evidence="1">
        <location>
            <begin position="5"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="87" mass="10072" checksum="1CE36C4CD3C50AE9" modified="2013-05-29" version="1">MDNSDEIVIIDLKDPCFKKNSRGFPEGPVQLKALESNTPFLQWGGHIYQGRWENMIGTELVFDESGQWLGQGRRRLIMERVQLVSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M7P7T0</accession>
    <name>M7P7T0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01679</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PET117 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873642.1">
        <property type="nucleotide sequence ID" value="XM_007875451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P7T0"/>
    <dbReference type="STRING" id="1069680.M7P7T0"/>
    <dbReference type="GeneID" id="19895373"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01679"/>
    <dbReference type="HOGENOM" id="CLU_161486_3_0_1"/>
    <dbReference type="OrthoDB" id="76305at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031568">
        <property type="entry name" value="Pet117"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163:SF1">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15786">
        <property type="entry name" value="PET117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082705" evidence="6">
        <location>
            <begin position="17"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="74" mass="8355" checksum="34942E4A8DD3A6F8" modified="2013-05-29" version="1">MSKAAKITFFTTATLALGTVGGVHYIQNQEKEKLYAGVLRDEAREAIRKEHQEKQINKEKPETSYKKIELSTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7P7X0</accession>
    <name>M7P7X0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01729</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873692.1">
        <property type="nucleotide sequence ID" value="XM_007875501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P7X0"/>
    <dbReference type="STRING" id="1069680.M7P7X0"/>
    <dbReference type="GeneID" id="19895423"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01729"/>
    <dbReference type="eggNOG" id="KOG1844">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4652">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_430269_0_0_1"/>
    <dbReference type="OMA" id="HACYQCL"/>
    <dbReference type="OrthoDB" id="1928087at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007130">
        <property type="term" value="P:synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15558">
        <property type="entry name" value="PHD_Hop1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051294">
        <property type="entry name" value="HORMA_MeioticProgression"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225">
        <property type="entry name" value="HORMA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225:SF7">
        <property type="entry name" value="MEIOSIS-SPECIFIC PROTEIN HOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="6">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="636" mass="72746" checksum="CA26C4B3EFDD7937" modified="2013-05-29" version="1">MMNVVNSKGEKQSFGVEEEYAKRCIQLLLRNLITLTQNLSPLPENKNRYITMKLFYTDATPQDYQPPMFRDCTMEKPFTFAVDPENTNFYKQTAGSIDTGFHAITLKITSIADAVSECKSFEEYQDKQIKTLSAEEDISEKESLKDSLKENNIIILDSQKKHQSCPELLPSLPQNNISKQSLKYVDERYEKEDAAIKEMLTTHTQDSGLEATQPLESNFSQITQNVSYVHSKPSFEYEAKVKYEKTREKNSKKLEVKKIVSVGENLSKLTLNFRKAFELNEEKKRLLCLRNTVKGSVKDIDVIRCECGDVSEDSGDMIQCYVCQSWVHAWCYGFISGNDERLPDDHSCYSCLLRKFEPVLYESMKDLALFRRALMIIWEEGLPESNSEFSNRLGCSRQNACQILKRLLQEGFIANITQNRASRTNTSKKNGRINMNDEMVVVKNAENKQRLFSEYFQPLLKISHHYEKQENVNTSFQKDKSVNSNASIDNSIPINALSITNSSGVDSLKDPNFIINATPLSELKDANIPKELCIKEINDINHNNAELDTTDDEDLSAQNIIKKPHLTESTNLINSNAGFGLQKHNTINNFKTYAISNINQIPKKNNKRTRLHFSDENFDTEAKKRKSSVILKPILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7P807</accession>
    <name>M7P807_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Squalene monooxygenase</fullName>
            <ecNumber evidence="14">1.14.14.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PNEG_01766</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>squalene + reduced [NADPH--hemoprotein reductase] + O2 = (S)-2,3-epoxysqualene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25282"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:15441"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 14">Endoplasmic reticulum membrane</location>
            <topology evidence="3 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the squalene monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.17" evidence="14"/>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873732.1">
        <property type="nucleotide sequence ID" value="XM_007875541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P807"/>
    <dbReference type="STRING" id="1069680.M7P807"/>
    <dbReference type="GeneID" id="19895460"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01766"/>
    <dbReference type="eggNOG" id="KOG1298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026390_0_0_1"/>
    <dbReference type="OMA" id="AKRTFYW"/>
    <dbReference type="OrthoDB" id="1678617at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004506">
        <property type="term" value="F:squalene monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000166">
        <property type="entry name" value="Squalene monooxygenase Erg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013698">
        <property type="entry name" value="Squalene_epoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040125">
        <property type="entry name" value="Squalene_monox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835:SF0">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08491">
        <property type="entry name" value="SE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 14" id="KW-0274">FAD</keyword>
    <keyword evidence="5 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene epoxidase" evidence="15">
        <location>
            <begin position="161"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMR10010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="457" mass="51598" checksum="D10521084DDA36DE" modified="2013-05-29" version="1">MYEWDCIIVGAGILGASLATVFGRQKRKTLLLERDISEPDRIVGELLQPGGIKALETLGIEDTIEGIDAVQVKGYQLLWNNKSISIPYTNKKLSYHKHISYQGRSFHHGRFVMKLRQHAVANESVTMIESTVLSVIENPLTQQVLGVKTFVKATQQYEHYFAPLVVIADGCFSRFRKQFISKPVTVKSNFVGLILENVTLPMPLYGHVILSNYSPILMYQLSTHHTRILIDIPGKLPSSTTGQLKKYLKEVITPILPENIQPSFTKALNNQKIRSMPNCFLPPSLNTKPGLIILGDAMNMRHPLTGGGMTVALNDVLLLSDLLSPSSVPSFRDTDLVLHQMFLFHWKRKKLSAVINILAQSLYFLFSPTDTYLNILQKGCFQYFQLGGIAINDPISLLSGINHQPLLLFFHFFAVVFYSIYLTILSSFNIFNIFSGLIVFFRACEVIFPYIWSELIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7P851</accession>
    <name>M7P851_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Plus3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01808</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873777.1">
        <property type="nucleotide sequence ID" value="XM_007875586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P851"/>
    <dbReference type="STRING" id="1069680.M7P851"/>
    <dbReference type="GeneID" id="19895502"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01808"/>
    <dbReference type="eggNOG" id="KOG2402">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036626_0_0_1"/>
    <dbReference type="OMA" id="ISGCYAR"/>
    <dbReference type="OrthoDB" id="166375at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000405">
        <property type="term" value="F:bubble DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="entry name" value="Plus-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004343">
        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115:SF8">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00719">
        <property type="entry name" value="Plus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="Plus3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51360">
        <property type="entry name" value="PLUS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Plus3" evidence="6">
        <location>
            <begin position="224"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="13"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="149"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="154"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="558" mass="64719" checksum="82012E97FD25631E" modified="2013-05-29" version="1">MIDDLSDELLALAGHKDIETVPQKKKSGHKKKASQKQFQDKKYNGNYKKSLRNNDDSNGELYSSEYSTESENLISREDDDNDYLEEYTVPYVLEGKFKDEEDRKRIMGMNEVERESILYEREEETQKLQEKKELAKRIRQEKFSIKKELKTRRSARETKGKGEETASKRDKLTELKRKREEKSNKTDSKLDDKTFNKRTKEELDKKYGNKHGSRSFEDKEDSSVLDLNDVNNTRLGRKHFAKFLFHPLFEGVIAGCFTRVKIGENPQGKSVYRVCQVKGLQPSAKIYSFEGVLSNQKLECIHGASVKTFEITFVSNSAITQKEFDRWTQQLKEDKIATPKKSLIEKKITELSLMTQHKLTDSEISDMIARRKALQKIPGNIAIEKTQLKKTRDIAIAHGDEKEAQRLTEKLNTLEELSEKRRHILTDSDKFAKLNEKNRKANLDTIRQAEIQANEERRKKDSSPILVNPFSRLKTNPKIFYDNILELQDSTLPKTDNSDKNIQTVDAYAKINIIDTKETENTKTNIPENTTPKTIRIKTLNNIDEIISQSNFDLDFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7P8B7</accession>
    <name>M7P8B7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dihydrofolate synthetase</fullName>
            <ecNumber evidence="7">6.3.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01399</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>7,8-dihydropteroate + L-glutamate + ATP = 7,8-dihydrofolate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.12" evidence="7"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873334.1">
        <property type="nucleotide sequence ID" value="XM_007875143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P8B7"/>
    <dbReference type="STRING" id="1069680.M7P8B7"/>
    <dbReference type="GeneID" id="19895096"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01399"/>
    <dbReference type="eggNOG" id="KOG2525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015869_1_1_1"/>
    <dbReference type="OMA" id="NENYLVY"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008841">
        <property type="term" value="F:dihydrofolate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF0">
        <property type="entry name" value="DIHYDROFOLATE SYNTHETASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur ligase central" evidence="8">
        <location>
            <begin position="29"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="424" mass="47216" checksum="A6DC19544EEF8AE3" modified="2013-05-29" version="1">MLVKLGLLRIRQLLKYLGNPQNSFQAVHVAGTNGKGSVCAYLSSCLALSGIRIGQYSSPHLMDRWDCVKVIGRDVDKDQFFEIESKIKILNQKCNIGATEFEIMTAVAFEILSKNNVELAVIETGVGGRLDATNVLSQVLLTIITKIGMDHQELLGNTIQKIAREKSGIMKKNVPCIVDGTNEDSVLKVIKEESIKSGSSKVILTPMDLDKSLYIQEWEKLKSETSLYRTYQGTNLACVSASLEILSEYYPKITPGILSKGLLETYWPGRLEWIDLSQIAFGANKILLDGAHNIDGINSLSEYVNSIRNGIQPVSWLTAFTQGKDVDSLLSILLKPYDKIHSVEFEPVDGMPWIRPVNSFYIAKIARKYLYKENIKQHGTDLLSAISSISQDKGLQVICGSLYLIGQVHRLLYKRILLQKGSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7P8Y9</accession>
    <name>M7P8Y9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01551</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873500.1">
        <property type="nucleotide sequence ID" value="XM_007875309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P8Y9"/>
    <dbReference type="STRING" id="1069680.M7P8Y9"/>
    <dbReference type="GeneID" id="19895246"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01551"/>
    <dbReference type="eggNOG" id="KOG3219">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088696_2_1_1"/>
    <dbReference type="OMA" id="LNQACNP"/>
    <dbReference type="OrthoDB" id="28335at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08048">
        <property type="entry name" value="HFD_TAF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000061">
        <property type="entry name" value="TFIID subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045127">
        <property type="entry name" value="TAF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006809">
        <property type="entry name" value="TAFII28_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04719">
        <property type="entry name" value="TAFII28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII28-like protein" evidence="8">
        <location>
            <begin position="45"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="149" mass="17696" checksum="F166BD7A30E92E41" modified="2013-05-29" version="1">MSQEKKHQLKTAEEEEETNDYGTSILSYNTQWAQLENQEKQRLKILLDSFNEDQMRRYEIFRRANIDKPSLRKMVNCILNQSITPNICIVISGFVKVFIGEIVEKALDIQKKWGHSGPLAPKHLREAYRLYKQETKRIPQNRVNRCLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M7P993</accession>
    <name>M7P993_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873050.1">
        <property type="nucleotide sequence ID" value="XM_007874859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P993"/>
    <dbReference type="GeneID" id="19894832"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01135"/>
    <dbReference type="HOGENOM" id="CLU_466236_0_0_1"/>
    <dbReference type="OrthoDB" id="5306163at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="585" mass="68243" checksum="F4DB17F5AF2E180B" modified="2013-05-29" version="1">MPHFLNIICHPDLIETIAEYMHFIDLVSLSCVCRTARYVIYDNDRCWRMIDLSYTKGSILERYQNAKETHLATFKTIQSLFRRSNIPLKYLTVIILDFSAIQYPAVRFIILQAGLGRLRKISLRHCRFISLKDLNSILMALQRVWSGEESYYKQSSSLAITPYVLKELRVRYMKGLPKYAKDLYYNYSQYNLLYIFREIAKLLRLETDVETCSMNYPNDLLHNREICIDYWNDHERVDYNIYYSAGDFFFNLSKAYRKCDIHSEIANYKFCGICLQSSQCAKCGESVCPLCQGVNQCNLFYLNIRGQDSNKHAPLKVGFCQQCGILCKNCRNSDIFNCLICLVPYCTIHMSSKVKYYCEIGGEGVCNKCVFKKPWLGQCFGGCGRIMCRKEVAGKCFKCHENICWQCIKLSMPLKSSFMKTSVTDNSSTSSDLYNTSQDSNAIIFREGMLKTICISCKVLVHMRKRKLESRKFCMIYGLKAKRFTKHMGRRRLALKLYQYSIKRMQFWTKKSLTLHRNNQNNLNKVELSPIEYNMNFTQISTIPSHYLKFTNVIKVAINEELENGISKKELADLIIRMTNNILTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7P9D4</accession>
    <name>M7P9D4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator complex subunit 15 KIX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01188</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873104.1">
        <property type="nucleotide sequence ID" value="XM_007874913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P9D4"/>
    <dbReference type="STRING" id="1069680.M7P9D4"/>
    <dbReference type="GeneID" id="19894885"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01188"/>
    <dbReference type="eggNOG" id="ENOG502QVXD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_289698_0_0_1"/>
    <dbReference type="OrthoDB" id="1938591at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.20">
        <property type="entry name" value="Coactivator CBP, KIX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036529">
        <property type="entry name" value="KIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036546">
        <property type="entry name" value="MED15_KIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008626">
        <property type="entry name" value="Mediator_Med15_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16987">
        <property type="entry name" value="KIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05397">
        <property type="entry name" value="Med15_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47040">
        <property type="entry name" value="Kix domain of CBP (creb binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mediator complex subunit 15 KIX" evidence="4">
        <location>
            <begin position="20"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR10475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1058" mass="120388" checksum="3E1D44F28F2C8808" modified="2013-05-29" version="1">MNQAPIIATHNEGTNVVPDRNWRSTLTASEKHAIIFHLVSALRAVSSNVSQEHLIAIVNAFEKQAYEKANSKTEYINICNSKLMYIKGSTAAKQHLSQAQNQRTTMPFFPQTPCQQVISGQMKTFEMSGASNLVSPSFTHSPRMSRQAMSSHSQFQQVPPLVNQQMTLQQKQMLMRQASVNQHLSNQNLMQGLSHSVNQQTHASNSASDALKRSAYSVPQQKAPQIQQMLTQLQTQNNQQQIPKYMSHQACVSQGLDERHQALNQQKIPISPQTDIYQQRVDNPLLNSSNTNLQKLLVLNQAIQSQNKQLNQPLSQTKQLLSNQTLQNFLSQAQAPVQQVVNQQAQKMPGHAIGSSTPSQEFKKKMDPYLNPCNYLIPQRILSQFPELPTNVFTWSQVAELIRNQRLSPEQVARLHELFYQHALYLQLHYQQIQYMSNQSSNQFRPQSPLQPTSQHHSVNPNPHIQQQMRKIPVQQMQQISKGGVSSEFLQHEWSSDTSNFPTQYSHSFSPNINVSLNNQTPQQLHPQSIDQLLTMVQCDNISGLKKKARVSLKVKKKDDIRSVNDQLPVLQTFNMASVSTQNQQTAQIRQDSSKNRPDISIVQRILMCGGKEANIQMNVRLRQIQNEVERNGVKNIPLNDLTHIQKQQVCELIAEMSQMYHRIDMLLPLFMILSWNESAIIQLLRMKLIYKNQLDVLPQGIYLCYPSQLIKIKKMISEYFKFVKISVQAIQKQIENGKSLPDKIPINLSEIDPNISNFQSFLEDFSSLEASNEASLLNPLKTDIKTNAKVDNSEIISINENKFDVTNNSDGIDLQIRENNISNSYDKSGSQTFELSKDSFYSQENNKIIEDPLDYTVLNVTNVLETDDVNMILSMDKSSLFNEEKSMDVLSNKFGSEIISSLVTKIPQSFTNIPLNHFSGKVQNDSNNISTIKNENLSSPETAFSLVTSDVLGTEKTLNDLDFEQYFDSTFNDKFYENNTSSFDKLQEKNVESLFFIDETNVENGLSEELEWDFGVFDIGSFKIKDFYASNNENIWNEELKTEDLSTIGLGIIANVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAC7</accession>
    <name>M7PAC7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872845.1">
        <property type="nucleotide sequence ID" value="XM_007874654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PAC7"/>
    <dbReference type="STRING" id="1069680.M7PAC7"/>
    <dbReference type="GeneID" id="19894631"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00933"/>
    <dbReference type="HOGENOM" id="CLU_1200271_0_0_1"/>
    <dbReference type="OrthoDB" id="7763451at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="27693" checksum="A5A39B90AE39EF4A" modified="2013-05-29" version="1">MNKIEVSNSSERLLEEKIRELFLSYGEIKEFKLSKELDGSHKIRIRVNSCETKKTELLSNDTQVKDSKDIEKKDFSNRQKNEEFFIFYVITVILNYFKGLVKQQVDVFIKYLSYIYAIASNIHEKGTKLDEKYKILDHLFVFFRVILKKIKTINDKYMVDQKIKNFNSKHNILNTIQEKGRIILYNFQYIMSTKTRNKIQVFYTELCKKCKNIHEEAYRLANLKQEKVKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAL5</accession>
    <name>M7PAL5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc-ribbon 15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872954.1">
        <property type="nucleotide sequence ID" value="XM_007874763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PAL5"/>
    <dbReference type="STRING" id="1069680.M7PAL5"/>
    <dbReference type="GeneID" id="19894739"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01041"/>
    <dbReference type="eggNOG" id="ENOG502SDGY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115926_1_1_1"/>
    <dbReference type="OMA" id="AVRTINC"/>
    <dbReference type="OrthoDB" id="5545479at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28139">
        <property type="entry name" value="UPF0768 PROTEIN YBL029C-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28139:SF1">
        <property type="entry name" value="UPF0768 PROTEIN YBL029C-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="10189" checksum="60173CA5EE6A290F" modified="2013-05-29" version="1">MFCFFLLGLQDFSNKIQGYENLVLYCPICHNISAIPLHEKKFFTICFVPLIPYGWGKVIRCTICSWFQHINDAELYRISQLSNLRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAS8</accession>
    <name>M7PAS8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein YIF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00578</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the YIF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR10975.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613313.1">
        <property type="nucleotide sequence ID" value="XM_019757725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PAS8"/>
    <dbReference type="STRING" id="1069680.M7PAS8"/>
    <dbReference type="GeneID" id="19894276"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00578"/>
    <dbReference type="eggNOG" id="KOG3094">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1272755_0_0_1"/>
    <dbReference type="OMA" id="SGYKFVH"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005578">
        <property type="entry name" value="Yif1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083">
        <property type="entry name" value="YIP1 INTERACTING FACTOR HOMOLOG YIF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083:SF0">
        <property type="entry name" value="YIP1D-INTERACTING FACTOR 1, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03878">
        <property type="entry name" value="YIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR10975.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="295" mass="33901" checksum="1D8C0E4B7855DD2E" modified="2016-03-16" version="2">MYGHQEDKDRKPFVMYAPQPAYFSTSRSSPVPGKQNPQTQQNTYTSYLGVNHAAAQMGLQVGRSAVMAGQEYVERNVGRFISMDMLRYYFNVSNYYVISKISVVLFPWRHKCWSRLTRHSEVNEAVVEGYRSPREDINSPDMYIPVMAFVTYVLLSSLLAGFKGDFHPELLGTTALMALIVVTFEILAIKFGCYILSIYNQTQLLDLVAYSGYKFIGIIVIMLSSIFHNLILTYSVFFYTFISIAFFLLRSLRYIVLPESNISLNATMSLSQRRKRIYFLFGISMAQILFMFILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7PBJ7</accession>
    <name>M7PBJ7_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00281</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872152.1">
        <property type="nucleotide sequence ID" value="XM_007873961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PBJ7"/>
    <dbReference type="STRING" id="1069680.M7PBJ7"/>
    <dbReference type="GeneID" id="19893979"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00281"/>
    <dbReference type="eggNOG" id="KOG1036">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038526_0_0_1"/>
    <dbReference type="OMA" id="WDSTLHI"/>
    <dbReference type="OrthoDB" id="10262475at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="103"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR11250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="339" mass="38642" checksum="C93B74DFFCB0D83D" modified="2013-05-29" version="1">MNKHNQWEITPSPLDGVSSLLFSPYTSMHLAMTSWDKTLKLLDIESILSNDDNKDSQNIILFSFEHKAPVLDCCFSNEIHIYTGGLDRRVRMFDLYASNVLVLGTHDDAIKSTLFNRNINLLITGSWDKTIRQWDSRSNNKSLNIYSLPQKVFSMDSVDYKLVVAMANRIVYIYDLRNMSEPLQQRESSLKFMTRVVKCMPDGQGYVTSSIEGRVSVEFFDPSPESQIRKYAFKCHRQVHDGIDNVYPVNALAFHPIYGTFVSGGGDGIVALWDGVVKKRLRQYPKYPASISSLTFSNDGKYMAIGTSDDYKDIDKETNANNKLFVRELFEEECKGKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7PBZ7</accession>
    <name>M7PBZ7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00428</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872306.1">
        <property type="nucleotide sequence ID" value="XM_007874115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PBZ7"/>
    <dbReference type="STRING" id="1069680.M7PBZ7"/>
    <dbReference type="GeneID" id="19894126"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00428"/>
    <dbReference type="eggNOG" id="KOG1390">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_0_0_1"/>
    <dbReference type="OMA" id="ICPSIAI"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000007">
        <property type="entry name" value="acetyl-CoA acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF165">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="8">
        <location>
            <begin position="10"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="9">
        <location>
            <begin position="275"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="402" mass="42505" checksum="2ED3CF53E0A29B72" modified="2013-05-29" version="1">MTLEIGETDVFIVSAGRTALGSFQGSLSRLSAVELGIHVVKNVVEKSCIKAEEVEEVVIGNVISANLGQNPARQCALGAGLSEKTVCTTVNKVCASGMKAVILGAQSILVKTADIVVSGGIESMSNVPFYNSSVRSGSRYGHITLTDGLIRDGLSDAYSDEPMGIAAECCALEYEISRKEQDDYAISSYKRAQKAHELNLFKEIIPIKVSLGSKEPSKIIDKDEEISNLNEEKLRIIKPAFKANGTVTAGNASTISDGAAALVLVSGKKLKELGLKPIAKILGWGEASQLPKKFTTSPYLAISKALKSARLSTSDVDYYEINEAFSVVALTNSKILKLDLNRVNVFGGSVAMGHPLGCSGARIITTLLSVLQHHKAKIGVAAICNGGGGASSIVIELLNPFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7PC46</accession>
    <name>M7PC46_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_03491</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the TIM50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875581.1">
        <property type="nucleotide sequence ID" value="XM_007877390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PC46"/>
    <dbReference type="STRING" id="1069680.M7PC46"/>
    <dbReference type="GeneID" id="19897178"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03491"/>
    <dbReference type="eggNOG" id="KOG2832">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023309_1_2_1"/>
    <dbReference type="OMA" id="NLRQPYT"/>
    <dbReference type="OrthoDB" id="287041at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046902">
        <property type="term" value="P:regulation of mitochondrial membrane permeability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000019">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10 13" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="14">
        <location>
            <begin position="130"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR08049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="402" mass="47164" checksum="C81B43441922D68B" modified="2013-05-29" version="1">MDVSKDINLRDKKFDENAFNSPKIFKIKDKMMLVLTNKESKNRKEYKSTADLRREKLASYTAWSFVAIGLGGACYMGRKWTDEEIKQSLDVKEKASSTFFGRLKQRTSSLFNYYNEPAFDKLLPDPLPDPYQRRFTLVLDLDDLLIHSEWSREYGWRIAKRPGLDYFLSYLSQYYEIVIFTTQYAATAIPIIQKLDPYRSSLSASLFREATKYVNGKLIKDLSYMNRPLDKIIMLDVNPDSYSFHPDNAIAMEPWKGDPNDKELISLIPFLEYIASMEVSDVRPVIASYKGKHIPTEWALREKMLKDNMKKEWEEQNKNSSSWVSFLLNGTAKRPYQVPQLITDQQRERAQHVYVEYQQYLKDHGEEILNQEKQREREQMSAMKTSINRLIFEGIPKPSEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCM3</accession>
    <name>M7PCM3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="8">4.2.1.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00098</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-NADHX + ATP = ADP + phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19017"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>(6S)-NADPHX + ATP = ADP + phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.93" evidence="8"/>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871955.1">
        <property type="nucleotide sequence ID" value="XM_007873764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCM3"/>
    <dbReference type="STRING" id="1069680.M7PCM3"/>
    <dbReference type="GeneID" id="19893796"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00098"/>
    <dbReference type="eggNOG" id="KOG3974">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030651_0_0_1"/>
    <dbReference type="OMA" id="WRAAYHN"/>
    <dbReference type="OrthoDB" id="8110916at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047453">
        <property type="term" value="F:ATP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110051">
        <property type="term" value="P:metabolite repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000023">
        <property type="entry name" value="ATP-dependent (S)-NAD(P)H-hydrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017953">
        <property type="entry name" value="Carbohydrate_kinase_pred_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592:SF0">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01049">
        <property type="entry name" value="YJEF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01050">
        <property type="entry name" value="YJEF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF C-terminal" evidence="9">
        <location>
            <begin position="7"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="183"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="217"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="329" mass="36567" checksum="42BF3C7E4D202D07" modified="2013-05-29" version="1">MFIPEKILTDLRKMIPPLLDHFHKGQAGRIGIIGGSEKFYRNFLRNSLIFGSYTGAPFFSCMSSMLFGADLGYIICEPGAGKVIKTYSPDLIVCPMMRLSTCNLKDVSSKIVSNISQLLDRLHVIVVGPGLGRDPLMLETASGVIVEARKRKIPIVIDADGFYCIQDNPEIIMGYRNCVLTPNVAEFSRLCHRFHLDENSSCQNLANNLGGVTILKKGRIDDISNGSKIFNVNIRGSLRRCGGQGDVLAGILSTFLAWRKAYLENLWDHDKSLNEDELLMLASYGAAFATRYCSYLAFKRKKRTMRASDLMDVIGDAYELLSEGDISNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7PD57</accession>
    <name>M7PD57_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872110.1">
        <property type="nucleotide sequence ID" value="XM_007873919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PD57"/>
    <dbReference type="STRING" id="1069680.M7PD57"/>
    <dbReference type="GeneID" id="19893939"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00241"/>
    <dbReference type="eggNOG" id="ENOG502SF1P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_679999_0_0_1"/>
    <dbReference type="OrthoDB" id="340259at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037626">
        <property type="entry name" value="NUP37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22806:SF0">
        <property type="entry name" value="NUCLEOPORIN NUP37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22806">
        <property type="entry name" value="NUCLEOPORIN NUP37 P37 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="45059" checksum="34E52D523BF50EFD" modified="2013-05-29" version="1">MESKIFFPISSYFDQKHKAAVYDIPGSVVEFCPFEQSSSLLAVGSKQGIILLRRIFSEIDELGDASKFQQFKESWCLQQLLYLQLGTKVTSIAFSPTTYIDLIDSEKIYVTLAIGCEENSARFLKLSSKAKDPKIVMLGGTSGHQDFINDVDTTYLNIIAKADETEFTGDIVATGGDDCTVIVWRMTDNSPQLSAYSTGSPVISVKFHRSYPRRLLVGEYNGTIKILDWVEAGGKWLISLYAGLTPYNFIKSNSTVCLADVDWASNKDDIGRIIAATTDGLWLLWDFDGKSDNISILPTIKKRIGSEINVKQLISRPGYPDIFAICLQRSLMISLTSHIKLVNIFSSTDLIDIELPLSEISKPEDSYISWHANEGIIAISRNSSLIISCVMNNDDFFANMSDFMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7PDD9</accession>
    <name>M7PDD9_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_03302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875377.1">
        <property type="nucleotide sequence ID" value="XM_007877186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PDD9"/>
    <dbReference type="STRING" id="1069680.M7PDD9"/>
    <dbReference type="GeneID" id="19896989"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03302"/>
    <dbReference type="eggNOG" id="KOG2076">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002391_0_1_1"/>
    <dbReference type="OMA" id="SSPNMKF"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043035">
        <property type="term" value="F:chromatin insulator sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039340">
        <property type="entry name" value="Tfc4/TFIIIC-102/Sfc4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="975" mass="113591" checksum="2777FD20CE00F145" modified="2013-05-29" version="1">MNKKQNVDGKYWRMLHDDEISNVELQGGVNSVSREFEAPCIDLGDKGLWSDDENVDNKDLRYRNVENNKGWMHGTVKNLKEDMMYEASKFQEDLRIASGFKKNKGRSKGRRGVADMEPSEEVKCLLGYANQAFASGDFSEALKTLQEIIRIDSNVFAAWQTLGEVHRERGNIDKCLGAWISAAHLKPKDADLWLTCAKLSQDAQLWDQADYCYNRAIHARPADVDAIWDRAVLARDRGRTKKAIDCFKSLLGIVPNDMSVIRQLARLYFQTSQVSEGIALYEKAVEYYLCFPAPFKDKCGLNWNELHIMSELYIADKRWKQCVYNVKYIARWLRGRKSEDFWDNYSDDREWDNDDERRKTVLHSFSEDKTLYNMPMELRVKLGICRIHMGDIGEGLRHFEVLDSNHDLEKNTDLIFDAANALTEKKLYYEALRFYSRLIECDTVNGPELCFSMGKCYRAINDLEAAEECFKEISSNSEKHIESLVQLADIYQITGRREEALDVVNKVIRYQQNENSTVAEVQEESQNITPRSTFIIDTKIPKDRISKKISLKPSLNERIAIEMRRTEHILFKWQKLNIVRDKMLQGDPHAVNEWLDTAGDMVDEFRNVRGFYPSEKSTKFKGVISVAKRRMQKMEINQKLKVMANRLQESLEFSDDESYRENTVNNDVNEFRGLTFDTWFYIFMQYAICLTKHDDFLDALEVIKAAMSANVFYQSHERLNKMHVTRLACSFWSKQYSIVAEECRYFSNLYKFRSDGYRLYFVAMPTGEAMLHYSANSALQKYLLRQIKSIDSAMSEKNKDSLSINKNENDSYIPTHYNVVLLVSYGHVMICSRSYVQALNYYGRAYALAPLDPLISLSIGMAYLHRAMQRQSNNRQYQILQGMTFLFRYYELRKSMGVYEHQEAEFNIARAFHQLGLTHLAIPYYKRVLSLIVSDSFENVYFDLRRHAVYNLSLIYVTSGNLSYARNLVDTHFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7PDE3</accession>
    <name>M7PDE3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">separase</fullName>
            <ecNumber evidence="2">3.4.22.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_03306</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage.</text>
            <dbReference type="EC" id="3.4.22.49"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.49" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875382.1">
        <property type="nucleotide sequence ID" value="XM_007877191.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7PDE3"/>
    <dbReference type="GeneID" id="19896993"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03306"/>
    <dbReference type="eggNOG" id="KOG1849">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000454_0_0_1"/>
    <dbReference type="OrthoDB" id="10255632at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051307">
        <property type="term" value="P:meiotic chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005314">
        <property type="entry name" value="Peptidase_C50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030397">
        <property type="entry name" value="SEPARIN_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792">
        <property type="entry name" value="EXTRA SPINDLE POLES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792:SF0">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03568">
        <property type="entry name" value="Separin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51700">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C50" evidence="5">
        <location>
            <begin position="1758"/>
            <end position="1853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1945" mass="223437" checksum="483ECD5CF5D0EF32" modified="2013-05-29" version="1">MSFFVLKKSLDTLLYKFSSLETCSPATLQEITKILTEDSVLRPISENSRGGLMSSGKSDRNFSKVKKENKVFTLKNDIVDRPEFAIKVFNECLKVLSQIVKKSVDCRKDFRGLESKKNIHYSNGSNYIGLAKQIVNCLLLSFKIIRENSSKLNIKQLGVCKAHANIINRLIDLEMISMAFEELISLRNDLECYIRLIVEQGFWAKSSKQNKLKINETNKAIHEIVAWLINIESPVDSLEEDVVNFIVGFQLMALRFASRHQDMTLDESLLNSFKSCFGPMAFFRRLNQLNPKLGKNQANLLYRVVLKLCSSHFSYISFQFQLCTIECLDEENISNNDNIMDGILRVIIHLSKINDSLVSYSFCKEAVEDFLNFTCSGILSRTAFINLIFYMSFYAEQIRNYSDVLNWNMLLINKFGQNDIISISLSFHNAFFELSGLFSIENGSYLKTAKENLSKLLSMDEDIQNASEGELIKLVKSLDRLRRSCISIIDNSTSHSQFCRSCLEIMLEFVRKYNVNNIGEKECFKVLGFNILTSIISFVKTDLTCSPPDKVDHLIHLLGISLEFAKSVNDISAIISISNVFWNFGITLHQNGDNAIDPIQRSILALESINFSNLDMDHYIGRYELLIKCYSLIKDYENSINYCFKAMDILFKSGIISQIASECNSAMLSDVFKEHRHVARIITSIVQNAIVGECWSERCLLKYLNIYERGPLLEWQLQVVLGLQYKYDISKQLYILQNNLMDIYNENFPVRRTRVLLQIYQCLENITSEMNDAFEELFRKGISDLMDNNLLEDISFESFRYNYIALSRSFLALKLFLNQKQWQDDMKAAFKIWKMLFDDIEHSKTQKTLGICIDNPLNLLCHFEMLTDFFLVKGLPLNRLAVLKLRLRLCLLSPELRGPGELTRIYAMLGLQYLYLGYTGKAGMIFATAQNYNQKMSLDIKSLVEFEIAYIEYLSTVGCASSSWNSFIKVAKIVNGNFQIWNTGIQVPLDQRIEWYSLVASGSFVYALIMLEKGAIFDAFHYVENSYRLYKRIIKKRFSTCNDNCKKPAFFELGRSHWKILNNFISCLLLLAKLYEIQGSALDSEYFYSQALEVAENINSYLATATVLVMLGNLYVKTGKFEKGQENFDKAKYFFSQIENIKESVSLLFAQANLQSRQKLWCLELESYLLAEKLLKELMSPEFIIKLDEIAMENVVTGIETMTLSSPSNLIDSKKPSFNKLSTQCECIVLSRLKGKIMTSKGYNFALQGKIIDGKKFLKESVLIECDMDDLIIHRLYQSKVCFLEAEVLLQNDPIYGVLQDSVISVPNIYMHRASDKSVTNKTKTRLDVSKPGLNGSRGRILSLLEETKKNIIEIFNEALNYGQSTLVRQLAQMMASATILQSALYIPGDNNQIRSIVPSYFLEISKMISFQRERAFLRKNTKLENNENQDVQWPLILEEFQDNISLDHKIISSELFSELFFCDISQFQHEFIDKIPHSWTILTIGVGESKNDLYITRLQRQLSPLVLRLPLNRSNSRDADQDTLTYDNVFNELNEIIFRSNETAQIAKNISTSAHKVVWWKERQELDAKLKQLLINVEHCWLGGFKGIFFQSNINQGSFVRFKISVNKIIAKHVFSRKIFRKNKNVVTFEIESRLLELFVKLDLNDSKIDEYLEDLIYFILDIFQFHGETVAYDEIDIDQMVVDFQEAISNYNKESAVLLEKEQQHLILVLDKSIQSFPWESLPCLRKLSISRVPSLYCIYDRLNSAKFDAYQKVNRNNGCYILNPSCDLINTQNNFEILLKNLEGWEGIVGREPDESELQSFLTSFEIFLYFGHGGGEQYIRKNTVKRLPRCAVSFLMGCSSGLLKDMGDFEPIGMAISYLLAGCPALVANLWDVTDKDIDRFSTSVLKHWGLISNDLKNQDQTAPKIGNSLVDAIAFSRDQCVLKYLNGAAPVIYGIPIYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7PE23</accession>
    <name>M7PE23_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SLC41A/MgtE integral membrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02897</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874935.1">
        <property type="nucleotide sequence ID" value="XM_007876744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PE23"/>
    <dbReference type="GeneID" id="19896584"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02897"/>
    <dbReference type="eggNOG" id="KOG3788">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056043_0_0_1"/>
    <dbReference type="OMA" id="WDPDNVT"/>
    <dbReference type="OrthoDB" id="666972at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228:SF7">
        <property type="entry name" value="SLC41A_MGTE INTEGRAL MEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="MgtE membrane domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="10">
        <location>
            <begin position="81"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR08719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="409" mass="46142" checksum="D6AB19ADD1FAED81" modified="2013-05-29" version="1">MDRLEPDTNEATYELLERHSVLETPYINNGNYHFQIIRELILQSTTSLVFSVIGSFLTGLMLNYIKTLISFQAFPILFILIPILLNLIGCLEMNLTSRLSTFANMGKLDTLEAQQTIIKRNLIILQMQSIGAGLLSGIIAFIFGCILPSLKQKSQLDFFVHDKSNELEKHGFSDQKLTLFKLQEKTLFKFFILIASSIMTGCISSAILGALISILVILALKFRVDPDNILTPIASSFGDLISVSIFCLVSVIFVSFFGLYTLIFFLSLILLFSIFIITNIINTYPITPTTWIPLLISLLITCGSGILFEKYIYFYSGIAFMIPISQGLSGNIGCIYASRVSTSLQMKNQQYKEIKWITITTLFFINFIFQVGFLIIIHQTKILSMNLTFIFVYQIITGILVSFKEHTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7PEV1</accession>
    <name>M7PEV1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Efficient mitochondria targeting-associated protein 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_02770</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM97/sigma-2 receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874800.1">
        <property type="nucleotide sequence ID" value="XM_007876609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PEV1"/>
    <dbReference type="STRING" id="1069680.M7PEV1"/>
    <dbReference type="GeneID" id="19896459"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02770"/>
    <dbReference type="eggNOG" id="KOG0012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086812_3_0_1"/>
    <dbReference type="OMA" id="IAMELFY"/>
    <dbReference type="OrthoDB" id="433124at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051987">
        <property type="entry name" value="Sigma-2_receptor-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016964">
        <property type="entry name" value="Sigma2_recept"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204:SF1">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031032">
        <property type="entry name" value="TMP_97_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="9">
        <location>
            <begin position="18"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="177" mass="21078" checksum="930EF3213982D610" modified="2013-05-29" version="1">MKILQIKNNSPSLIRRPIDFLYTCYFVVRIFVALLIDLVPIYPAKLTLEKLTKLQLWYISTFKDPLMGWKSYPGGWFFSFIFCEAFFQLPLFFYGIRGLYYNNPRVQIPILIYATHTATTVFACIFELIFFNVYFITLEDKIILVFLYLPFFVIPCIMILDMVSRLKHRLIIDIKHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7PF79</accession>
    <name>M7PF79_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874471.1">
        <property type="nucleotide sequence ID" value="XM_007876280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PF79"/>
    <dbReference type="STRING" id="1069680.M7PF79"/>
    <dbReference type="GeneID" id="19896155"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02462"/>
    <dbReference type="eggNOG" id="ENOG502RZQV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1454992_0_0_1"/>
    <dbReference type="OrthoDB" id="2100652at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014807">
        <property type="entry name" value="Coa1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042432">
        <property type="entry name" value="Coa1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08695">
        <property type="entry name" value="Coa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="186" mass="21697" checksum="92D116B609DE6F41" modified="2013-05-29" version="1">MDKMNRLNMNFRNNSLLTLIKPFEASRVIVSCISQSFKQVNLRFTHQNTYSWPNTLSRKRKIVYVISGITIWAFVLGVSFNYQRYCSPVISYLMYELKRSPTVETYLGKNIDFSSKWPWIYGKINNVKGHINISFRVSGSKDSAIVKFKSVRKEKGVDWVTLEWTISPSKNHEEISLLDELNLLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7PFK1</accession>
    <name>M7PFK1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Class E vacuolar protein-sorting machinery protein HSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Class E vacuolar protein-sorting machinery protein hse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_02569</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STAM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874583.1">
        <property type="nucleotide sequence ID" value="XM_007876392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PFK1"/>
    <dbReference type="STRING" id="1069680.M7PFK1"/>
    <dbReference type="GeneID" id="19896261"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02569"/>
    <dbReference type="eggNOG" id="KOG2199">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010104_2_0_1"/>
    <dbReference type="OMA" id="CNTSEDW"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031321">
        <property type="term" value="P:ascospore-type prospore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11805">
        <property type="entry name" value="SH3_GRB2_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16978">
        <property type="entry name" value="VHS_HSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="13">
        <location>
            <begin position="15"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="198"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR09234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="424" mass="49989" checksum="63989BFFB3B79923" modified="2013-05-29" version="1">MNQKLETIEALICRATDEYLTQENWEYILDVCDCLNQGGDIKMAVFVLQRRFLCGNESIQLYCLSLVEALVKNCGLSVQREVSSEVFIEIFLKYLEDVNAHFVVKERILLLIRQLALDFASSPLFEYVRKVYQQLKFEYKYIQKENKRDEQGEKEEKELQLALALSLEKNEENPYNYQKKTKYSEYNPLTSKRDYSTAIISRVRALFDFHASEPGELSFQRGDIITVLEVTHKDWWYGSLNGKMGIFPNNYVEKLQEPTPDELRMEIENEIKVLSYEENIEKLLEILSNVGLTENNNIIESEKFQNLYHSTLTIRSNLIKLIKKYAQKKGFQAVFKIHCLNLVDDIISLNERFVKAMKDYEILMEKSMTHFSYTSLHNQSVQQYHDKKHDDFQKYPSHLNFPCQNEGISHSTESYYSVRRDNTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M7PGE8</accession>
    <name>M7PGE8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SUZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874098.1">
        <property type="nucleotide sequence ID" value="XM_007875907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PGE8"/>
    <dbReference type="STRING" id="1069680.M7PGE8"/>
    <dbReference type="GeneID" id="19895810"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02116"/>
    <dbReference type="HOGENOM" id="CLU_1732246_0_0_1"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12752">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUZ" evidence="2">
        <location>
            <begin position="54"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="151" mass="17584" checksum="E92193F06F6E3F39" modified="2013-05-29" version="1">MNDQKYQEKVPDLWDEWENENRIVGFPNDKADLSCNKKTTHEDNVRLWKEANQQVPDVEILNSPRTVYKPSLKILRRSVDHLYNSSASTVLPQKPISTESEQGQREKEQRYREARQKIFGVSSTKKDLYIPVRSPIGPLLGEGFVKEKDQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJ91</accession>
    <name>M7PJ91_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01234</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal PrmC-related family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873153.1">
        <property type="nucleotide sequence ID" value="XM_007874962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJ91"/>
    <dbReference type="STRING" id="1069680.M7PJ91"/>
    <dbReference type="GeneID" id="19894931"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01234"/>
    <dbReference type="eggNOG" id="KOG3191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018398_6_0_1"/>
    <dbReference type="OMA" id="DVNRNAC"/>
    <dbReference type="OrthoDB" id="406152at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052190">
        <property type="entry name" value="Euk-Arch_PrmC-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875:SF1">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR10524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="193" mass="22110" checksum="7782338D0B9540C6" modified="2013-05-29" version="1">MFRNRERKRKYMIYIELIQDSCGSGCVSVFLQTAIFGSSKSLHICTDISLPACEATLETLKINSNSMKTFYLDVIHTDLIQGLYLDNNVDLIIFNPPYVPSESKEIGINKNSENIWAGGIEGMEVTYRILNSIDKILCVHGLFYLVAISRNKPEKIINFMKTQWNMQSKIVLKRNAGCEQLYVIRFNKPNKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7PKB1</accession>
    <name>M7PKB1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH myb-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01035</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872948.1">
        <property type="nucleotide sequence ID" value="XM_007874757.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PKB1"/>
    <dbReference type="STRING" id="1069680.M7PKB1"/>
    <dbReference type="GeneID" id="19894733"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01035"/>
    <dbReference type="eggNOG" id="ENOG502QRT9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008791_4_0_1"/>
    <dbReference type="OMA" id="IQEQQIH"/>
    <dbReference type="OrthoDB" id="3366990at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000137">
        <property type="entry name" value="MYB DNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013867">
        <property type="entry name" value="Telomere_rpt-bd_fac_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052833">
        <property type="entry name" value="Telomeric_DNA-bd_trans-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47807">
        <property type="entry name" value="PROTEIN TBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47807:SF1">
        <property type="entry name" value="PROTEIN TBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08558">
        <property type="entry name" value="TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="5">
        <location>
            <begin position="455"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="540" mass="61679" checksum="FF0ED54CFA876F23" modified="2013-05-29" version="1">MEGQITEKKRSENYVDENHEMSGVDEDYSEAFRKKTKLKRELNVLNHETFTQNLNTTHEESHARLEDIQQELASEFHPDLSMLEHLPTVGQDPHAFLHEEAPQQIMDPNQNLCIQSLPILDNLSSQILSILGKGPHQETLNIVTRPDTAKGQAYRTLTSLFNQVKKLYSTEAFLNPDLLDLRAPQHRATIRKVNLATFVSSVFGSVEVGFFHLNEHFLDTFVPDGARLLKSQSALFLNLKTQAYISAIDQGEKPKEEILDDLFPPNMDQILLRRRNGAKNLTPNESDFVARCKSRKNHLAKFPVNENLSEKYVWQIFLRDVSEYITRNYESIVSQPIRRHRRISSKIQASSQGHPSESVLQVALYRQNQDPGSNKSNHMTHIQHIAQMQQIGHIQDLHDDTDEATAMALNGVDANLFTDSNLHLNLSPTTEHALSTQQLYEQARQAARPSPSRRGKPAQRRPWTKEEEQALFAGLDQVKGPHWSQILTLYGAGGTISEALKDRNQVQLKDKARNLKLFFLKNQLEVPPYLRFVTGDLKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M7PMH4</accession>
    <name>M7PMH4_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871969.1">
        <property type="nucleotide sequence ID" value="XM_007873778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PMH4"/>
    <dbReference type="STRING" id="1069680.M7PMH4"/>
    <dbReference type="GeneID" id="19893810"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00112"/>
    <dbReference type="eggNOG" id="ENOG502SFEK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1670115_0_0_1"/>
    <dbReference type="OrthoDB" id="2120038at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034444">
        <property type="entry name" value="Nuo17.8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42100">
        <property type="entry name" value="OXIDOREDUCTASE 178 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42100:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 178 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="158" mass="18668" checksum="9274AFA56E42C9CB" modified="2013-05-29" version="1">MIYQYKKAINPLLLRNIKRKLTNMSIDNSKSKIVSKSQDEDFSAPIWRNSILCVFCLLVVYKIDEWYGLHHEGKGGFTRVIEYFIKDEEKYRELNIENLKKISEIAKERLHQQDSKRKSIYRLKFPEQLNQGSSYNLKVGTEIDLSQYNIKSDVDSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7PMZ9</accession>
    <name>M7PMZ9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WIBG Mago-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872129.1">
        <property type="nucleotide sequence ID" value="XM_007873938.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PMZ9"/>
    <dbReference type="STRING" id="1069680.M7PMZ9"/>
    <dbReference type="GeneID" id="19893956"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00258"/>
    <dbReference type="HOGENOM" id="CLU_1835967_0_0_1"/>
    <dbReference type="OrthoDB" id="5385624at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903259">
        <property type="term" value="P:exon-exon junction complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039333">
        <property type="entry name" value="PYM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015362">
        <property type="entry name" value="WIBG_mago-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036348">
        <property type="entry name" value="WIBG_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959:SF0">
        <property type="entry name" value="PARTNER OF Y14 AND MAGO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959">
        <property type="entry name" value="PYM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09282">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01273">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101931">
        <property type="entry name" value="Pym (Within the bgcn gene intron protein, WIBG), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WIBG Mago-binding" evidence="2">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR11834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="140" mass="15749" checksum="3115697B838A4470" modified="2013-05-29" version="1">MLKIDIQKNNKRASGIKSLQDGSSIIPSSVRPDGSIRSERKVRPGYVPPEDISVYRAVHYDGSCQRMSCNQLGAHGYRPPGAMVSSNLSKSAKKRAKRKEKFQNSKDDTECSESKTKDCHSIIDDIEKCMRNFKIKETKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWU7</accession>
    <name>A0A0W4ZWU7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major surface glycoprotein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_04007</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="KTW32839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613321.1">
        <property type="nucleotide sequence ID" value="XM_019757766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWU7"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZWU7"/>
    <dbReference type="GeneID" id="30671543"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04007"/>
    <dbReference type="OrthoDB" id="5477726at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021041">
        <property type="entry name" value="Maj_surf_glycoprot_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003330">
        <property type="entry name" value="MSG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02349">
        <property type="entry name" value="MSG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12373">
        <property type="entry name" value="Msg2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Major surface glycoprotein 2 C-terminal" evidence="3">
        <location>
            <begin position="908"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="761"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1073"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="761"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="810"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="862"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1081"/>
            <end position="1101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KTW32839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1124" mass="125713" checksum="BA6B1925693C43F1" modified="2016-03-16" version="1">MAQPVKRQAAGQAAGNDEIKEEQVLGLIVKSGYNNDNKCKANLKHYCEELKKIDGKLESVDVKVKGLCENGKEEEKCKSLKDKVKTELDAFKTEVENALNNLTDEKCRKYEEKCLLLEEADPNNLEEKCVKLRDRCYRQRRQGVAKEILLRALEGKVNDTNECKKKMKEICQGLSEYSDELVFSCFNSDKTCEYLQKNHGDSCKPLEKELEDKELVEKCQEYLEKCYFYGSSCKDTKCDKVKNKCKGKGIEYEGPKLDFSPVREKPRFPEKIEVENLYKKEEAKGIIVGKPKYKTLRDLALLLIKERNGKDEGEKCKKALEDCESFKHLDYGLEELCGDKDKEDRCKELVEVEDRCTNFKLELYLKGLSTEFEKDKESDYFSWGQVSKLVSREDCIKFESECFHLEGVCTNKIGKACENVRVACYKKGQDRVLNRYFQEGLKGLIGDLELVTENLEKCQKSVVGNYTKLKEDRRYFTKCHLPTKLCYELLDDVILQSEELEVVLNLRRDFPRKEDCVELKKKCKDLESDSYLNHEKCDTLNRRCEYLKVTEELRKRLLKRGDDALRTQGNCTAVLKKECEELSRRGKEDFSVSCALREETCSFMVEQTENECLFLKNNMDIGKIIEKIENGKRNETLVEELCTLFDPYCHQYIENCPDRLKKTNNAGRKGVCLELEEKCKPFFEKLKLENELTHKLKGSLSDETKCKETLGKHCTEWKKEGNQTLNSLCEDAKKEELCKKLVKKVKEKCPTLKNKLDNEKDELEKKKDEYEKVKQESEKFAKEAKLVLSRPEQNGQGGGSKAQDGSVPKPVGPPVQPPAPAQPTPGGVPVPAPTLAPPAQPTSGGAPLPVPPAAPGGTPGGAPVPVPPPAPGTPPAGPAGPSGPSGGTPAGPPAPGGSTPSGTTNTSNVILVRRTFVSGEVSEPEKKAFVATARALELYLELKEKCKGLQGDCGFRKDCPGCEAACKEIDKLCEGIEGLKVTPHHTVISTATQTTTTTATTTTTTTTTTTTTTTTTTTATTTESVDGGKVTEECTLVQTTDTWVTSTSLHTSTLTSTSTVTSTVTLTSMRKCKPTRCTSDSSKETETQKEEEKEEEVKPNEGMKIRVPEMIKIMLLGVIVMGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NI15</accession>
    <name>M7NI15_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_03373</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875456.1">
        <property type="nucleotide sequence ID" value="XM_007877265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NI15"/>
    <dbReference type="STRING" id="1069680.M7NI15"/>
    <dbReference type="GeneID" id="19897060"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03373"/>
    <dbReference type="eggNOG" id="ENOG502QUGB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_367650_0_0_1"/>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12453">
        <property type="entry name" value="RRM1_RIM4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12454">
        <property type="entry name" value="RRM2_RIM4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034352">
        <property type="entry name" value="Rim4_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="188"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="269"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="362"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="733"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="734"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="758" mass="84130" checksum="F3078533075F06D1" modified="2013-05-29" version="1">MKPDTSPLLEPGSGTASSNSSPPSPKLLDTFLADAPNTPITPFTNRDSGNNTDNTSPLDFYSQDDKDVCVITPEEASSPFIFAQKDQELSNNEKCVPKVSTVYFEKANSEYSDGEASFSIPDISSLSCKDLNEEGIKKGVQYEGGVLVKPEENKTSCLLSKETMFSHETIYPAKKVGESSENRGRPAACLFVASLSSSRTDEELCASVTNHFRKWGNLLNVKVLKDWMQRPYSFVQFENFEDAKRALREAHNTVIDGRHIRVEKARVNRTLYISRIGQSLEEQDVKNLLEPYGEIEDIVIPSSSNQMLRNDMGKCCFARFAFRDDAIQAFSNLRRNGNWIVEWAQNLDQNTSQIPMIPIDKTSVFVGQLNPSLVTRESLLNRFKKYGEIVDCSLVNKPNSNRTAFAFLQFESATSASAAVENENNSNFLDRVIRVQFRELYDKTDLSTYDSRSLLPSINPQSQFACKFPLSVPFIPRLRSRSNDSLSLTNRGSIYGQDNSGVHGYYPEVTNQAFSMRSHEAFMAAYRAALAATTSLNQPSAINTQNGYSGNIQVPYPGTPVGLTNYINSNSSTSGYANQHTMMNIHQNSNIIPSPFYYFAGGMSVPPQNITSNSLNQDSLSPQQERVKGNNVSPPFLSHWGAFVPTFIHGPGTSMQASVSLPGHSFSHQDSMNRFYHFPEGISNGSMHPAWDPSFGYYRLDNQCSPEMLAFPVQVPTVQDNLSSSFPVYGEVSGHNTDQNVHPPYSHNQATVNGGITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJE5</accession>
    <name>M7NJE5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP synthase subunit f, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874948.1">
        <property type="nucleotide sequence ID" value="XM_007876757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJE5"/>
    <dbReference type="STRING" id="1069680.M7NJE5"/>
    <dbReference type="GeneID" id="19896595"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02908"/>
    <dbReference type="eggNOG" id="ENOG502S739">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152700_1_0_1"/>
    <dbReference type="OMA" id="TIDYQMH"/>
    <dbReference type="OrthoDB" id="5561579at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019727">
        <property type="entry name" value="ATP_synth_F0_fsu_mt_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10791">
        <property type="entry name" value="F1F0-ATPsyn_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="11708" checksum="3200ED5718F42F94" modified="2013-05-29" version="1">MRLQHIPFHRWIPPKLTPNLNLMDASRVRRIIDFYARLPRGPAPTISPRNWVEQYKKTYFNGRGKAQPVLHAIGGLVIFGYILDYYFHLRYHKHSIHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJQ3</accession>
    <name>M7NJQ3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 12">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_02625</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 12"/>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874644.1">
        <property type="nucleotide sequence ID" value="XM_007876453.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJQ3"/>
    <dbReference type="STRING" id="1069680.M7NJQ3"/>
    <dbReference type="GeneID" id="19896316"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02625"/>
    <dbReference type="eggNOG" id="KOG1494">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047181_1_0_1"/>
    <dbReference type="OMA" id="CIVECAY"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF73">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="13">
        <location>
            <begin position="25"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="171"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="31"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="141"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR08838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="340" mass="37142" checksum="C99F60AAA6D283BA" modified="2013-05-29" version="1">MFKTWSIFISAFYSRRFSSITYNATKVSILGAAGGIGQPLSLLLKTNPRVGHLALYDIRGAPGVAADCNHINTPCKVVGYGEDDDGLIKTLKDTDIILIPAGVPRKPGMTRDDLFVTNASIVRDLAKVAADVAPKAHLLIISNPVNSTVPICAEVYKKRGVYDPKRLFGVTTLDVVRASQFISDMKDIESKNEHVHIVGGHSGVTIVPLLSQTSHNFTDQEIKFLTNRIQYAGDEVVKAKNGSGSATLSMAFAASRFTDSLLRAMSGEKGIIEPTYVESPLFQDKGCHFFSTNVELGPKGVHNIHPLGNISLYERELLELCFPELSKNIEKGIKFVEETY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NKN8</accession>
    <name>M7NKN8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CAF17 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02544</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GcvT family. CAF17/IBA57 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874557.1">
        <property type="nucleotide sequence ID" value="XM_007876366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NKN8"/>
    <dbReference type="STRING" id="1069680.M7NKN8"/>
    <dbReference type="GeneID" id="19896236"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02544"/>
    <dbReference type="eggNOG" id="KOG2929">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_7_0_1"/>
    <dbReference type="OMA" id="MDRLHGV"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057460">
        <property type="entry name" value="CAF17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GCV_T_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602:SF0">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25455">
        <property type="entry name" value="Beta-barrel_CAF17_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="CAF17 C-terminal" evidence="5">
        <location>
            <begin position="226"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00093447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="332" mass="38400" checksum="0FA9121B40C86EB4" modified="2013-05-29" version="1">MTRLNPKRRLIEIYGLDAGKFLQNMISNNIPSEGPGSGVFSGFFLPQGRILCDAFIYSIAHNSVWRKSRSISENKNYQAFFIECDVRSVENLLNHLKHYKLRSRVSLELVDNDEWSIWSSWGIDEKNDCKIKESIGCYDYRAPGMGRRDILPYNIKPTFELDEVPLENYRIKRYLLGVPEGPDDIFENKAFPIESCLDYMGGINFYKGCYIGQELTTRIYHAGVVRKRIVPISFYNPNDSPPSILKYIPSLKFYFPVQATNIVREDSTEKNVGKFCSGIGNIGLGLMRLDSVFNQSEQHKYIIHHTDQDNNNHIIGVKAFHPWWWSEKHINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NL71</accession>
    <name>M7NL71_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEATR5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874362.1">
        <property type="nucleotide sequence ID" value="XM_007876171.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NL71"/>
    <dbReference type="GeneID" id="19896051"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02358"/>
    <dbReference type="eggNOG" id="KOG1822">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000503_0_0_1"/>
    <dbReference type="OMA" id="NQCENAD"/>
    <dbReference type="OrthoDB" id="192608at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046837">
        <property type="entry name" value="Laa1/Sip1/HEATR5-like_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25468">
        <property type="entry name" value="HEAT_HEATR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20210">
        <property type="entry name" value="Laa1_Sip1_HTR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1995" mass="231187" checksum="65E8DE48D711AD06" modified="2013-05-29" version="1">MTIFQIDLTKLECISKEEKEFILFNILLEISEELENFELEQLNIKQTEILQILFQIIKPEILVPSRIIRNQLGRCFQILFSRSNSISIFSAFNILLENILLPKIEDFDLHIKWTSLIILKHIYIASKNKLSIHLNDTIDATFKIFKISNNIIELRESCFETLSVALNSCKCIIDENKTKKIFKFIKLGLSDKTDIIKLKALMCFKELLKICVPISGYTDIDTVKNMTTKFINNHVLSIHDQAAKVLAIMLITNSKLDTKNSNFSLEENREMQSNGSPENEILPTSPKKYIYFNSNSKKKYIFYLKYISDIYAKHITNSHIEEFIISIYSEFLEHYEKEWIISHYKFIIKNHISDIASVINNIKDKEKISTTRNIICRFLSIIRKKLDEDSQFRALKILNEEYLSIWLDELGFTQAKKLVLTGILCEISKFILTLSNIINTIRESLRDNLLFILNCTSLTIQKYTSWCIKCFAITIPNDITYLMIFCLKHIKKFISTDINNIDYLSKLRIRGYALALSRLISIGKQNPLYISSDIFSEIFLISCSILKLTRNNAIHTILIHVQIAWTLISSLMKLGSSFVRSHLSELFLLWKDTLLNPSINNLPPEANQLETLFLLYTREYALGSIFSFLLHNKELLTTNVLKKTSFMLNETNTLLILLSKRQKNSIFLDDYVQLSQEMLENMIHKRILQCYLLIIWKNPEDSTQNELISRLITKFASPYVTIVKNTLNYQSYYHLHSNQNIDGISSFIHLQDFSNYQEIYEINNIVLQNYIYVPKDYALINIGNNLNFNLQKNNSLQLYDILSSFDEIPWNQLSIYIEIIDLSILLFGIIFLNQSNKIKESILEQLITFITLSSNIKPFQQKIAVICNSNLAVLGILRFIENNVNQINNLKNTRAIDLMEQIAKHGTNSQNPAIRRISCETIGRLTCLQKKQLLPSIKFYMREIIELDNSDSRSSSALCLGRILNHYKKMVPSSYISKILDVLQSLSIDQNSEVCFWALESIAIGIQSFGPDMSSYCLNILNVISKIYNRMDYNTSNTSITISNLSLRFPILCNLTRCLNAIVNIFGPDLQKNTEAKKLVSVLIRGLLLENNEEVLAEAIYCAQHILLFSSDLLNPYLFVKLLQTNIMSKNKNLARASVKSLYQLMQHDTLSVFKWGESNLDAYIWLAYDSNPEIEELKNIIEIWLYHTSDSLQNYWIHLCLKTFEKKSSNKIIQKVNKNISRSLKNEESCIFKIDESYNSDNIQEKLKRLRWQTQKLMLQCINNLLSMEFYFKKYSNSQISQKISSMSSNISNLIKIGFMASTGKNYDIRFEGLKIIQKIIKIFSPFKDPDFPTLSLLEQYEAQLVSAIIPSFSSDSIPEIAVFAMHICSYFLTSEILKEIPKTGRIIKLLSSALLNINNSEDTISIGDLKCSDNSQILLKLSIVSVWAELQIASEHKTCLSFIIKPNLSLLIPLWITSLRDYTKFCFGTYELSNNLSHLTSQSINFNKIFSNINNNELFEICNKFWINMVYAISILLESNKNIIFESITWYESNNSDSMKLDKRTNHKKKTSTLFFLLFGICFEALLHSIPNKKVINTDKQKLYILSALEKILNISLHNEIIYSDTTFSELVTLLKRLLLTEHPIIQILIIRIATSLVNNYPVKNQKHFKNNKNYSDQQENMPNYPNKLHELSEIIILPLIFYFQHTNTTINDLKAHEHMSNLIIYSLESYIKIIKRFPLIIQYDFYDCTFFIILKLYFNENSYHLIPKILPLVKILCEDILTTSKIDQKSYQISQNLIENILDQITRIIQDLPKAWEYGLPLATVIMTITGQILPPKSKSFQKYHSLFTKSPTNDEAKILIHCMKSLLTSFSCIKRYILQSILFASFNIIKKAYLDFKKSAIFDIGTNACNIIIDLIKNISGNNQQYIAMVTIMPILIRFASNEQLKSSHKKEISFKLLSLMACFGKNFHQILKKIPKKDSDMLKNLFKYTYSSMPISLETESKIFKKININ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLN8</accession>
    <name>M7NLN8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial outer membrane protein porin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02164</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic mitochondrial porin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874145.1">
        <property type="nucleotide sequence ID" value="XM_007875954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLN8"/>
    <dbReference type="STRING" id="1069680.M7NLN8"/>
    <dbReference type="GeneID" id="19895857"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02164"/>
    <dbReference type="eggNOG" id="KOG3126">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044399_1_0_1"/>
    <dbReference type="OMA" id="FKQPAFH"/>
    <dbReference type="OrthoDB" id="7827681at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07306">
        <property type="entry name" value="Porin3_VDAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000012">
        <property type="entry name" value="Voltage-dependent anion-selective channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF70">
        <property type="entry name" value="GH26960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00185">
        <property type="entry name" value="EUKARYTPORIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0626">Porin</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31013" checksum="637D84D9405CFCEE" modified="2013-05-29" version="1">MSNIPNYDDFAKSQNDIFYKDFPINGTSLDVKTKVPNGVEFSVRGHQPSTVGTIIGQLEGKYSDKLSGFVFCQNWTTENALTTKITLENHLAKGLKADIHTTLFPLSNTKTAKLGLGYKQPSVNIRTMVDLFKGPTFSGDIVVGKDGFIVGGNVDYDILNGTITNYATSIGYSQPQYSVAVQATQNLSVFSASYYHRVNAVTEVAGKMTWDTRRPTSMISLEVGAKHLLDKHAFIKAKINNDGIAGISFTQTLYSGIRVGLGLSLDTQRLSEVAHKIGMSIAIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLW1</accession>
    <name>M7NLW1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_03354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875435.1">
        <property type="nucleotide sequence ID" value="XM_007877244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLW1"/>
    <dbReference type="GeneID" id="19897041"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03354"/>
    <dbReference type="HOGENOM" id="CLU_767512_0_0_1"/>
    <dbReference type="OrthoDB" id="5401193at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="361" mass="40826" checksum="7D57ACF705A48C9F" modified="2013-05-29" version="1">MSCVETLLGHPRSYYDLKMIPNSFSDDIPFSSQFDDVDKAIENLVKCGKLFFWKNSLQFAARSYSEHDYRSSYPLIGRQTGIYELEHMHSQPAANPLSYHANQHYYNQRTASHTEQFPLSRRKNKSYSECSIYTALERSGSEQLPFSRERIKTPLIKDGIPAANDDMMYSKFSETPRVLPDYIYEELGLKNSSISTLFLPRESSSHIYPFTCFQEYSTNLNAAVESRAGNNVIGIGDSVKKSLPFFYRKKNIMENNEVLSLVSTNKVKNILAPIGTKSSSVSLSVDPLNQQVQDTSTVVKPLQYSFSSGKVLKNDMYNGIFLKKYMGSGKSVPWNGRIWSDDAKNLGITSNNNGFGLNVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NM89</accession>
    <name>M7NM89_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="3 11">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_01952</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3 11"/>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873929.1">
        <property type="nucleotide sequence ID" value="XM_007875738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NM89"/>
    <dbReference type="STRING" id="1069680.M7NM89"/>
    <dbReference type="GeneID" id="19895646"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01952"/>
    <dbReference type="eggNOG" id="KOG0888">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060216_6_3_1"/>
    <dbReference type="OMA" id="QHYGEHK"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000002">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="12">
        <location>
            <begin position="2"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="9">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR09768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="151" mass="17318" checksum="47CBBD229DD67B7C" modified="2013-05-29" version="1">MDEQTFIAVKPDGVQRGLIGTIISRFERRGYKLVAIKFIKACRELLEQHYRSLREKPFFDSLITYMTSGPICAMVWEGKQVVRIGRVILGETDPLASALGTIRGDFAIDIGRNICHGSDSVSSAQREIQLWFDEKELLTWESHNYSWIYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMJ0</accession>
    <name>M7NMJ0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_03269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875340.1">
        <property type="nucleotide sequence ID" value="XM_007877149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMJ0"/>
    <dbReference type="STRING" id="1069680.M7NMJ0"/>
    <dbReference type="GeneID" id="19896956"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03269"/>
    <dbReference type="HOGENOM" id="CLU_138679_1_0_1"/>
    <dbReference type="OMA" id="IVREWPS"/>
    <dbReference type="OrthoDB" id="2107880at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061671">
        <property type="term" value="C:Cbp3p-Cbp6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037653">
        <property type="entry name" value="Cbp6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28250">
        <property type="entry name" value="CYTOCHROME B PRE-MRNA-PROCESSING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28250:SF1">
        <property type="entry name" value="CYTOCHROME B PRE-MRNA-PROCESSING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20180">
        <property type="entry name" value="UQCC2_CBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="119" mass="14255" checksum="2751554235AA94FB" modified="2013-05-29" version="1">MQKPTYREILKLIKKIPDDILRPHANLKIILRQRTYNYFKQNGKEKSIESNDSAQNINESHDQYLALQYLVSNKYKLKFPLSKKMLHPPRDPNYYQRIIESIKPKPSLSSIFAKWFGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMT1</accession>
    <name>M7NMT1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase II-associated protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_03268</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RPAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875339.1">
        <property type="nucleotide sequence ID" value="XM_007877148.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMT1"/>
    <dbReference type="STRING" id="1069680.M7NMT1"/>
    <dbReference type="GeneID" id="19896955"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03268"/>
    <dbReference type="eggNOG" id="KOG1894">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031074_1_0_1"/>
    <dbReference type="OMA" id="GHRITID"/>
    <dbReference type="OrthoDB" id="348201at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039913">
        <property type="entry name" value="RPAP1/Rba50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013929">
        <property type="entry name" value="RPAP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013930">
        <property type="entry name" value="RPAP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483:SF18">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08620">
        <property type="entry name" value="RPAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08621">
        <property type="entry name" value="RPAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RPAP1 N-terminal" evidence="3">
        <location>
            <begin position="101"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1 C-terminal" evidence="2">
        <location>
            <begin position="250"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="43404" checksum="4725D0499FA4F8D7" modified="2013-05-29" version="1">MKDQAGFLKGDRIDICLNEKCEFVEKEKKYEKDLSKSESEWLAKDIVEKNENDLEKSKEVHCVVNYEKTGFPISKKLFWKSLVKQYDESNKRLEKEFLLSEEINEGNMKRISKMTLEEIKEAKEELMESLNPELIEKLMYKKGLDKDVNDVMNKKKKVHFSCDDQDSLGMVSTFNEKKEEMASPSIDIHFPVPPFEDLDPSSPDFFKQLHSKYFPNLPEDPSKLAWMMAPTKDEDEMDYHESMTEIAPESIRFDFNANILSPRVSREIPMYIGLHHHANAPLAAGYSIPELVHLSRSMFPAQRCIAILILGRIMYKLSKYTYGFIVTDALKNVMKKSNAMESLIDAASEKNRHLSVKSYAEEALYLSNCESNNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN30</accession>
    <name>M7NN30_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="4 10">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01843</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Has kinase activity and phosphorylates inositol-1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="10">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IPK1 type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="4 10"/>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873815.1">
        <property type="nucleotide sequence ID" value="XM_007875624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN30"/>
    <dbReference type="STRING" id="1069680.M7NN30"/>
    <dbReference type="GeneID" id="19895537"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01843"/>
    <dbReference type="eggNOG" id="ENOG502S7VH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031304_0_0_1"/>
    <dbReference type="OrthoDB" id="272370at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035299">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.110">
        <property type="entry name" value="Inositol-pentakisphosphate 2-kinase, N-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043001">
        <property type="entry name" value="IP5_2-K_N_lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456:SF2">
        <property type="entry name" value="INOSITOL-PENTAKISPHOSPHATE 2-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR10093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="293" mass="34591" checksum="746505D1F0D85941" modified="2013-05-29" version="1">MNINRLKKINPDDWAYFSEGNRNIIFKYTGNDSFFINKVLRIKKMHHPVSTLENINFIQRVVTPLFHEPFDRYILTIEPIVLENVSLKIFNIYLTQKNKRKKKYENTLLDINETHAILLRDLSSDFPKSTIEFKPKWLTQSMLAPNGWKSCRTCALRRFRGDLTTNGIRYCPLDLASGNKVRIQKSVRAILIKNHIYNQNIETNLTLYFQHSQLIDHLKYLQTSSPRALSMTFCDCTIYVIFLHEEVFDIKILDLDCKPETKVEYWDKTEGQLINENWYLGRGMIDNEEPCTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNH6</accession>
    <name>M7NNH6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01512</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873453.1">
        <property type="nucleotide sequence ID" value="XM_007875262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNH6"/>
    <dbReference type="STRING" id="1069680.M7NNH6"/>
    <dbReference type="GeneID" id="19895207"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01512"/>
    <dbReference type="eggNOG" id="ENOG502RQI2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029376_1_0_1"/>
    <dbReference type="OMA" id="KTILQVY"/>
    <dbReference type="OrthoDB" id="77989at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="7">
        <location>
            <begin position="334"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="50784" checksum="CCB8B71D03572D39" modified="2013-05-29" version="1">MNTKNLGLFEEGINPNRPYYIPSEYSYDINQGIRRNVTEQSSNKNWTESEYLNYFNLEGNKKLLKTLLLETVFLYLSVFIAQPFEIAKTLLQCQYHVKPGLQSDIEDKNKFFSEKMEEEDEDNDSIISNESDPPYFRDPDSLISSPDISCTSKKSIVDREGYVLTSPDNHEIYFPWQINVQNCGIRMAMSTLWKKEGILSLWKAQNISFVYNVLFSITESWISSFLLSIFSFPTFISRTIDFDNLLSSSFISLTSSAFTSLLLAPIDTARTRIMLTPKYLKSHQHLSSEPFFSFLICPTMLILPTLFYATLPNAFSYIVSIFFNRSGLVIDSYETPIMYNLISLLSSLTHLFIKLPLETILRRAQLHISNLKHSLIKPGRYIGISGTIWCILYEEDSRPYGLNGFYRGLKMSLYTLIGIWSLGFTSLSLDLPSNLTNLSSFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNI7</accession>
    <name>M7NNI7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_02869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874906.1">
        <property type="nucleotide sequence ID" value="XM_007876715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNI7"/>
    <dbReference type="STRING" id="1069680.M7NNI7"/>
    <dbReference type="GeneID" id="19896556"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02869"/>
    <dbReference type="eggNOG" id="ENOG502RY38">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_518871_0_0_1"/>
    <dbReference type="OMA" id="LEYYSEW"/>
    <dbReference type="OrthoDB" id="2240312at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000500">
        <property type="term" value="C:RNA polymerase I upstream activating factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039601">
        <property type="entry name" value="Rrn5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28079">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28079:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="61583" checksum="C1CB129C673B1C6E" modified="2013-05-29" version="1">MIKKLDNFDKELCKNEKKIIISNEVTSNEKKMDGFVRLKGLFRRRSMFRMTVFRKRRLKSRCIPEHINPVYLQLLNQTIKEIGEDRDVGIMRNILESSEINGEIWTSLEKERFFKSLSRRSRHNPEDIARDIGSKSVMQVIGYMNILDEELKAFRLFCEGNGKEIVSFRHIPAAMEMSDEWINIEEKEAKKIQEFTDKIQEKQEKLTWGPEWSFLENKKTNEIEIAWDYVSESFSSIQEPLLKVSPEICFLRPKSFIELSEKLFFNRDTEFFSKEVVLYRTTLVHMYELARRLTQRLVQMAHFIALSRLRAERSSNFHSQYVVRSKDVLVAVDILGINRNSDEYWLNLPRRIEMTVLNETGQKLDFDAIKNKLSKIPLSTIRRRAKGVHLCNNFSGIEDNYIHLEDNSSAISFISDNSQVSNNENTSSDMDELSPILNDQENVSFNTNDDSSFVALENLDDEQTEEMLMKTEDNFLEVLDARKSAVDERELWRKLSYFYKSKKNNVSLANCSSQLEKLEAILRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNJ1</accession>
    <name>M7NNJ1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcineurin subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Calcineurin regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Protein phosphatase 2B regulatory subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02874</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Composed of a catalytic subunit (A) and a regulatory subunit (B).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the calcineurin regulatory subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874911.1">
        <property type="nucleotide sequence ID" value="XM_007876720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNJ1"/>
    <dbReference type="STRING" id="1069680.M7NNJ1"/>
    <dbReference type="GeneID" id="19896561"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02874"/>
    <dbReference type="eggNOG" id="KOG0034">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061288_10_1_1"/>
    <dbReference type="OMA" id="DTNFDRD"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR08696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="176" mass="20081" checksum="E47D1EED997645A1" modified="2013-05-29" version="1">MGYKNSKLIDALSNLPHFNQEEINRIHECFMKLDANHSGSINACEFLSIPQIAKNPLATRLFAVVDEDGDGNMNFEELIKSLNIFSSKGHKREKLLFTFKIYDIDRDGYISNGELFLVLKMMTGNNIKDLHLQQIVDKTIIDADQDKDGKISFEEFTQIIINTDVTKNMALDSTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNM2</accession>
    <name>M7NNM2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_01538</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873483.1">
        <property type="nucleotide sequence ID" value="XM_007875292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNM2"/>
    <dbReference type="STRING" id="1069680.M7NNM2"/>
    <dbReference type="GeneID" id="19895233"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01538"/>
    <dbReference type="eggNOG" id="KOG4534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019224_0_0_1"/>
    <dbReference type="OMA" id="FARAQPQ"/>
    <dbReference type="OrthoDB" id="3361892at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032931">
        <property type="term" value="F:histone H3K56 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013178">
        <property type="entry name" value="Histone_AcTrfase_Rtt109/CBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016849">
        <property type="entry name" value="Rtt109"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF2">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE RTT109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08214">
        <property type="entry name" value="HAT_KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01250">
        <property type="entry name" value="KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51728">
        <property type="entry name" value="RTT109_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR10273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="378" mass="44023" checksum="C3AB55A02F258A72" modified="2013-05-29" version="1">MVNLYTEISKSIEFLPSEISFSYGYVFTNFKKLKWPWMSKKKIDNVSLSNHFFFVLQENAMAYAIEVLIFFSSDLSVFYISKADSTGFFNRHDSPSPLKPVISSFLSYLIKKFSRRNIPSRISLFSRSQPQYLFPSSSLNPSKHILDDKELVKWWLRVLDCVKGPQCPKKYVLIPGIDARETLRYTPEHTNTDLKWICGHPYQPTDQPAGEIIPRFPDDPKTRFLDQLYKDGEGEVTSIDKFWELMAFRQECTLGRIVGFFSLEFPGSDQDEINNCMTEDLNLENGIQINEKIYRMAYEKLLRSDFETLEKTKGATLDWIHNINNSKDIKNTVDWIKKVSGKKTCEDKKRKTADISEQSKTINILNESLIRKKNKKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNN4</accession>
    <name>M7NNN4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LYR motif-containing protein Cup1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874668.1">
        <property type="nucleotide sequence ID" value="XM_007876477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNN4"/>
    <dbReference type="GeneID" id="19896338"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02647"/>
    <dbReference type="eggNOG" id="ENOG502R7F4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1054196_0_0_1"/>
    <dbReference type="OMA" id="YRETSCL"/>
    <dbReference type="OrthoDB" id="5521299at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20251">
        <property type="entry name" value="Complex1_LYR_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046896">
        <property type="entry name" value="Cup1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20263">
        <property type="entry name" value="LYRM2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYR motif-containing protein Cup1-like N-terminal" evidence="1">
        <location>
            <begin position="7"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="264" mass="31579" checksum="6A988B6A8E1D14C6" modified="2013-05-29" version="1">MGSAASLYRQLLIYISFFDEPIRLYLRGYVKMRFMVNRNLKDPARIKKAFRDGKMGLISLKKATFGDLKSLEKILDWTYGRRGRRKHELLRPFLAPLRKGIAAIPGLPRTKFPVLSPEFRALVQSQIPDWLSRLEMNKSTENKILNRKRQANIRWKCFSFIYRKILPPLPLQEIQKLEQFSRGEKIGLTPFFFRKQRSPMPRSTDAHYMTLRFRRRIYQRLLMKCPRLVYRMNHGWTIEWSKEAPIKNMRANLIHQDMFSDKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNS2</accession>
    <name>M7NNS2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874713.1">
        <property type="nucleotide sequence ID" value="XM_007876522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNS2"/>
    <dbReference type="STRING" id="1069680.M7NNS2"/>
    <dbReference type="GeneID" id="19896380"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02689"/>
    <dbReference type="eggNOG" id="ENOG502S067">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017878_0_2_1"/>
    <dbReference type="OMA" id="HYNEVQD"/>
    <dbReference type="OrthoDB" id="1696305at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050896">
        <property type="entry name" value="Mito_lipid_metab_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434:SF1">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="1">
        <location>
            <begin position="261"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="489" mass="56431" checksum="E329CFEF5D0E9AF1" modified="2013-05-29" version="1">MIKKNNIWSFRGIYFTLEMYSRKTFFFFPISLSQLRKYSIKNICSGCGSQFEEIYSKHSSDTMYNKSKIIKNFKNSKKQKENDIFNEAIANLDETLCLELLNIFPERLSGSFQEKKVKKRTICQRCHDLIHHSTLSTEFPALPQTLSSANWLSILLKEKNPLLICIIDSIDFPHSYISELHNLYGKISQILYVINKIDIICGKKDMLSKIRDYFVSEISKLAQITEKEIKPFIILTSATKGWGIDKLITSINKYKTKKSNIYFIGMTNVGKSSIISKFANQAGYEETPTVSFLPGTTLNPININANKLRNLFKDGGIIIDTPGISEPDRQLFKHFECNKLRIYIPKKKFPRIKPFSIKPGQSLIIEKIVRIDYLDTLKTDNRLIVTPYIFLPIHITNRKKAEYIFKTISSVDNMTTHDKTSLKNEAKILYYNLTESIEHKKHKDIVIAGFGWITTRTNYGSANIKIFSLESKGVALRNSLMQYITSRHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNW9</accession>
    <name>M7NNW9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_02956</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875001.1">
        <property type="nucleotide sequence ID" value="XM_007876810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNW9"/>
    <dbReference type="STRING" id="1069680.M7NNW9"/>
    <dbReference type="MEROPS" id="A01.018"/>
    <dbReference type="GeneID" id="19896643"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02956"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_3_0_1"/>
    <dbReference type="OMA" id="KYDHDAS"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000036">
        <property type="entry name" value="Vacuolar aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000002">
        <property type="entry name" value="Vacuolar aspartic proteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082324" description="Peptidase A1 domain-containing protein" evidence="13">
        <location>
            <begin position="18"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="14">
        <location>
            <begin position="84"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="115"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR08786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="401" mass="44754" checksum="A9ADFD614D357903" modified="2013-05-29" version="1">MLLLKVLILGWALTALASFQKIKLIKLKPNNEDKKIPLTVQVSALVEKYMSHFSKIDTSHIVDKEKPRDDLHEVSLTNFFNAQYYTQIKLGTPPQTFKVVLDTGSSNLWVPSSKCTSIACLLHKRYDSSLSSTYLANGTEFQIRYGSGSLSGFISQDVLHIGDLIVHSQDFGEAISEPGLSFAFGRFDGILGLAYSSISVNNVVPPFYNMINQKLIPEPIFSFWLGTIEKDIEGGECVFGGIDPNHFDGNITYIPIRRKAYWEVNLDAFFFGKDMIELSNTGIILDTGTSLIVMPSDVSELLNNAIGATKLWTGEYIIDCNKTSTLPDIVFRLDGHDFSLSSHDYILKVQGMCLSTFIGMDIPPPAGPLWIVGDVFLRRYYSIYDLGKNRIGLSNAKKRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP14</accession>
    <name>M7NP14_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01162</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873077.1">
        <property type="nucleotide sequence ID" value="XM_007874886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP14"/>
    <dbReference type="STRING" id="1069680.M7NP14"/>
    <dbReference type="GeneID" id="19894859"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01162"/>
    <dbReference type="eggNOG" id="ENOG502S8QA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_568773_0_0_1"/>
    <dbReference type="OMA" id="EGEYYVH"/>
    <dbReference type="OrthoDB" id="5591786at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014839">
        <property type="entry name" value="Crt10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08728">
        <property type="entry name" value="CRT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="173"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="471" mass="53499" checksum="71C8C9B69729607A" modified="2013-05-29" version="1">MEPLDFSMKICRRISLSGVKYWRCGLVSVGLKNIFVGVDDVIRVYEKSQSDGLVENLFRELKCQVEPHSVIRGEIDVMTPLSFNSIKVGYIGNEEVLVCCTDSGFVNVWFTEDLLRSPLILNTGRSAWGIAIHPSKMLLAISSNSHDISLWSLGVVNPFEEWNTNNTGWPHKFYGHNDNIPSICFNRSGTILSSAGIDATCRLWDVISGSLLHVYMDSHRGWFVGFVDSIAFKVLKRVDLSEKQLKSSSNQVNISSMDKNYINEDNLLHMIENCSDLDDEKETALHESDTDDSLEVQNSFYTNLSVRELFKQSNLISSDSLDFFSFEKHDDFFSCYTSINYNELLFYGTEKSIKICCVRETLPGIQLSAECKNIFDNNENIESILRYMDRINMVEFIPDLSLCIVASQKGKACLMHMARSVVKCKDGTILSSYTIIADQQFPEDPPLCGLLGMTVEKVFLRLYKLYVRLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP81</accession>
    <name>M7NP81_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Actin-related protein 2/3 complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01228</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ARPC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873147.1">
        <property type="nucleotide sequence ID" value="XM_007874956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP81"/>
    <dbReference type="STRING" id="1069680.M7NP81"/>
    <dbReference type="GeneID" id="19894925"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01228"/>
    <dbReference type="eggNOG" id="KOG3380">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101888_2_0_1"/>
    <dbReference type="OMA" id="LWHEKAF"/>
    <dbReference type="OrthoDB" id="195498at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.190:FF:000003">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.190">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006789">
        <property type="entry name" value="ARPC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036743">
        <property type="entry name" value="ARPC5_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12644">
        <property type="entry name" value="ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04699">
        <property type="entry name" value="P16-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039096">
        <property type="entry name" value="p16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69103">
        <property type="entry name" value="Arp2/3 complex 16 kDa subunit ARPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="152" mass="17609" checksum="CF1157A34F098AC5" modified="2013-05-29" version="1">MSFRQKQIDIYNNDRLKKEDLFEKEKRLPDEIREDISKRTPILLGMILQGKAVEALIQALINPPYGDVDDAKKRHMDTIFELLSSIKPNEIPNVIKTLNTEQQDVLMKYLYKGFTDPKSYNPAILLNWHEKLVKTAGYGCIVRSALTDMRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPB9</accession>
    <name>M7NPB9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Asparagine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02451</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874459.1">
        <property type="nucleotide sequence ID" value="XM_007876268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPB9"/>
    <dbReference type="STRING" id="1069680.M7NPB9"/>
    <dbReference type="GeneID" id="19896144"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02451"/>
    <dbReference type="eggNOG" id="KOG4198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022834_1_0_1"/>
    <dbReference type="OMA" id="DWKCGEN"/>
    <dbReference type="OrthoDB" id="448399at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140453">
        <property type="term" value="C:protein aggregate center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071502">
        <property type="term" value="P:cellular response to temperature stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031445">
        <property type="term" value="P:regulation of heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12452">
        <property type="entry name" value="RRM_ARP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.10:FF:000024">
        <property type="entry name" value="RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034351">
        <property type="entry name" value="Nrp1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23111:SF40">
        <property type="entry name" value="RNA-BINDING PROTEIN INVOLVED IN HETEROCHROMATIN ASSEMBLY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23111">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="244"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="7">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="7">
        <location>
            <begin position="424"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="7">
        <location>
            <begin position="552"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="647" mass="72859" checksum="5890B4D3FE541C23" modified="2013-05-29" version="1">MPLLESLDSIIIVHGSTCYECGIGGSKEAPELIELSWILVDAKTLEEQHKEDFLVRPVNTPITNLSNFIALTWENIQAAGTFREVIHHFATFIQEKLILNNKNFIFAAFDAKKLTIQLPKEARDKSVILPSYLQHPRVYDLHTEYSRWQSYHPETLVYRSSNITHIRRILETDIHALSQFAQQNFQVSFENTSPRRAIDECLDLLYIFKSLVEKSKLVDKYPDIFSRPLDIRADVKAFLAERSCILYMAGLPYDITQSELENWFTQHGSHPIAFWTLKTPDQYKPTGIGFAIFSSHEEAIKSLVMNGRAIEDRIIEISPSSSRVLERAAEILIPFPLSKNKPRPGDWNCPFCGFSNFQRRTACFRCSFSAFPANINDDPMMACSYVSFGGNFPLQPSVSNADPSFPSYPLAIRTSTQGGNVPFRAGDWKCKAEGCGYHNFAKNTNCLKCGANKNTFTITDHNISSSSISSQIQPVVNPTSYLSNSKNPAYSHPMQQIPLNTTHNSFYRSSILTSFSPLKQPAVPINNETIAQSNGSIVNKEKVITNKNNEKETNTWHCTSCFFINLKFRNTCLLCGTAISNTPTSASSITNSTIIQENSDTLECFNENMTSELLHEDLKALIIDDNKSLIDIKKDTSSKMTLLPLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPZ5</accession>
    <name>M7NPZ5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF572-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872823.1">
        <property type="nucleotide sequence ID" value="XM_007874632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPZ5"/>
    <dbReference type="STRING" id="1069680.M7NPZ5"/>
    <dbReference type="GeneID" id="19894610"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00912"/>
    <dbReference type="eggNOG" id="KOG2990">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050402_1_0_1"/>
    <dbReference type="OMA" id="YDDAMYK"/>
    <dbReference type="OrthoDB" id="360327at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF2">
        <property type="entry name" value="SPLICING FACTOR YJU2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="37999" checksum="BC5D245347D5F1D9" modified="2013-05-29" version="1">MQGFNKYYPPDYDWREGKGLNKLHGTHALGNRARKLDKGILIVRFELPYSIWCETCNNHIGQGVRFNAEKKRVGNYYSTPIWSFRMKCHLCSGIFEIQTDPKNTEYVVISGAKQKNENWDSTDAGVVVSKDDIEEDYKDDPFYKIEKSVADMNKAKESIPLLTRLYELNEKQWADPYSVSSRLRKIFREEKKMLKKEKESDEEIRNRNSLGIKLAKKDPKDHLQAKLVDFQPQINDLIEITKKEIYSSPLFIQKASPVSIHHKSNKGNIIRQLKLNTRMKNDHFITQHSIFTQHRPLKFNTSQQTLIINDDPQVSQGLVSYKSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ87</accession>
    <name>M7NQ87_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872933.1">
        <property type="nucleotide sequence ID" value="XM_007874742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ87"/>
    <dbReference type="STRING" id="1069680.M7NQ87"/>
    <dbReference type="GeneID" id="19894718"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01020"/>
    <dbReference type="eggNOG" id="KOG2167">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004747_7_0_1"/>
    <dbReference type="OMA" id="NYQEQTW"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043494">
        <property type="term" value="C:CLRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140720">
        <property type="term" value="C:subtelomeric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033621">
        <property type="term" value="P:nuclear mRNA surveillance of meiosis-specific transcripts"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140727">
        <property type="term" value="P:siRNA-mediated pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="6">
        <location>
            <begin position="459"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="819" mass="95443" checksum="5DAAA14FDB2F514E" modified="2013-05-29" version="1">MRIPQDCKHLKTKRRKESNLKNIMSITEHKVRGSKWSECDRIGNSDNKTNIEIDVSKEVIDLTRSPKKHILDEENTLKKLTIKNFRKTSLESQEKYYNDVLEKLDMALISIFERKKIVWSLQELYKGVENLCRAFNQPNNEDPWAIKCYRILETRSKESIKLLLLNVLEKISSFIETEGDIVKIVIEKGWEIWIEQISTIRNIFFYFDRTFLLITPGLSSIWDTGISLFREYLFMDISVNEPFFFDLFSIIASIRSYSMDFKKAPNIHLLQSSIKMINSLNLYGSLFEPKFIQATEIYYNNKALELIEKSYPEEYLSHIKEILNKEEKFCKEFFSEQTKSKVIRVIEIQMIENHSECIINTGFEKMMVEGNTKSLKDLYTLLKLVNKVELIKIHLAEYIKKTCKNSISNSKDNSNIIPSLLKFHSTLNSIISECFLSNGSFIQTLRECFEFFINNSIDNSAEMLAKYIDNMLRSGNKSFDEESLGNEMDKTLELFRFIQGKDIFEAFYKRDLAKRLLLNKTASTDAEKAMLLKLKTECGSGFTQKLEGMFKDIDISRNFMAFYKNSKSTQKNPPVSNLYVNILSQAFWPSYPNISVILPEKMEKDLNSFSSFYFSKEKDKKLTWRHNLGHCVVKANFPKGKKELNVTLFQAVVMLLFNNVPDNKTLSYNEIKKSTGLEDKELIRTLQSLACGKVRVLLKSSKGKDINTTDLFLINLAFSEKLFKIKINQIQLKETSKENKIIHENIQKDRSFEIQATIVRIMKAKKKSHHTELVQTSINILKQRGIISVNEVESAIEKLLEKEYIEKDEKNSNTYIYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQC6</accession>
    <name>M7NQC6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major surface glycoprotein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02415</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874420.1">
        <property type="nucleotide sequence ID" value="XM_007876229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQC6"/>
    <dbReference type="STRING" id="1069680.M7NQC6"/>
    <dbReference type="GeneID" id="19896108"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02415"/>
    <dbReference type="eggNOG" id="KOG3544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010455_0_0_1"/>
    <dbReference type="OrthoDB" id="5400168at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021041">
        <property type="entry name" value="Maj_surf_glycoprot_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003330">
        <property type="entry name" value="MSG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02349">
        <property type="entry name" value="MSG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12373">
        <property type="entry name" value="Msg2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082352" description="Major surface glycoprotein 2 C-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="domain" description="Major surface glycoprotein 2 C-terminal" evidence="4">
        <location>
            <begin position="880"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="822"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1057"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="767"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="835"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="865"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1064"/>
            <end position="1083"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1107" mass="126347" checksum="C60A21F06A38EB3B" modified="2013-05-29" version="1">MINKIILIAILNLIALTYGNQNVDLSIRSSQTNAVDPSFENFIVDKENIYAFILKKDYDDENKCKAKFEEYCEELKNIDPELNKVDSTVKEICNDNNKEKKCKVIKRIIQEKSKKMAKNIKDFSYYGGSNDVCTKYIEECSFFQDIDLGEIKKSCILLRNECSKKKNTIISQEIILRTLKMSSISLSECKSNIYNFCSLLAWESDTLMKLCIDKSNLCLELRFTTRHLCLSISRDFDNNKECHEQLENCYFYTPFCQNVKEKCDKWEKECLKKNITYKSLDLDLNPLKPPKTVLQKIKLEDIYKKEADKGSIIGKPEKIGFRDFILFLSRLEKMYNIEEACENAVKKYCKNTEYLSYEINSFCQDQNKEKKCAELTNVKARCINFKLKSYLKGLSTEISTKESRALDWDKLPKSLTRKECIYFSTECSRLLGICENGISQVCDHINEVCYRKAENAALNKIFMPALRGILDNFESNATMLSCQEKVLDICATFKNSNKRYFAKCLRPKEQCLELKNYISSQSEELEKVLDNVRDLPKESNCIELQEECRDLRGYSNSIDNKCVILNRRCRYLEITKELKKRLLKRGDDVLKTQGNCTAGLKKECKELSRRGKEEFSVSCALREETCSFMVKQTENECIFLKNNMESEKIIDKIENGKTNETLVEEICMLWYPYCHQYMENCPDRLKKGDNGSGKGICLQLEEKCKPFFEKLKLEDELMHKLKGSLGDETKCKETLGKHCTEWKKEGNQTLNSLCEDTKKEELCKKFVGKIKEKCQTLENELNKEKDELKKKKDEYEKVKQEAEEFAKKAKLLLLRLGKDVQGAESKVQDNSSPKSVPPSALPPAQPQPPTGSSRLPSGGIPAGLPTPGGSTPSGTTNTNNVILVRRTFVSGEVSETEKKAFVATARALELYLELKEKCKSLKGDCEFRKDCPGCDAVCTEIDKLCEEIKPLKVTPHHTMTLMTTEITTTTMITTTTTMITTTTTTTTTTTTTATKSIHGEKVTEQCAFSQTDIWMTNTSLHTSTMTSTSTVTSTVTSTVTSTVTSTVTLTSMRKCKPMRCTSDSSKETETQKEEEKEEEVKPNEGMKMRVPEIVKIILLGVMVIGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQE6</accession>
    <name>M7NQE6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 18">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="6 18">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PNEG_02081</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines. Negatively regulates the biosynthesis of acetyl-CoA from pyruvate in the mitochondrion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 19">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="6 18"/>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874060.1">
        <property type="nucleotide sequence ID" value="XM_007875869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQE6"/>
    <dbReference type="STRING" id="1069680.M7NQE6"/>
    <dbReference type="GeneID" id="19895775"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02081"/>
    <dbReference type="eggNOG" id="KOG1367">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025427_0_0_1"/>
    <dbReference type="OMA" id="DMIFDIG"/>
    <dbReference type="OrthoDB" id="275353at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000003">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000019">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF0">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="11 18 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="24"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="64"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="373"/>
            <end position="376"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00016471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMR09492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="418" mass="45838" checksum="2B5D305C06CB6E5A" modified="2013-05-29" version="1">MSLSNKLSVRETVLKGKRVFIRVDFNVPLNLNKEITNNQRITSTLPTIEYVIKEGAKAVILASHLGRPNGKRNEKYSLKPVSEELERLLQRNVLFLDDCVGENVEKICKEATNGQIILLENLRFHVEEEGSSKDAEGNKIKADPKDIEKFRKSLTSLGEIYINDAFGTAHRAHSSIVGVDLPQRAAGFLMKKELDFFAKALENPQRPFLAILGGAKVSDKIQLIDNLLDKVDILIICGGMAYTFKKILEDMEIGTSLFDKVGAENVKFLVEKAKNNNVKIVFPVDFITADKFDKDAKTGYTTDKEGIAADLMGLDCGHKSIELFEEVIKQAKTILWNGPAGVFEFDSFAYGTKKILDAVVSSSKSGNMVIIGGGDTATVATKYGQVHNISHVSTGGGASLELLEGKSLPGVSILTDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQG0</accession>
    <name>M7NQG0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873015.1">
        <property type="nucleotide sequence ID" value="XM_007874824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQG0"/>
    <dbReference type="GeneID" id="19894800"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01103"/>
    <dbReference type="HOGENOM" id="CLU_1704982_0_0_1"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="39"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="154" mass="18288" checksum="4E7F6154B3FB4C07" modified="2013-05-29" version="1">MSFNLPFSDKWSDISSEYIYNFINHYLRLDSHFCNSRCNTFLILGLDPKTYFTNEELKEAYRKRLLQVHPDKQYKKLYSLFFLPTSTGTAYSVCNSEFSLSCCGDMFVLNPQKIQVGEFLDACHFKYYTRINNKNWHFIIDFLILKILLKIGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQL0</accession>
    <name>M7NQL0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00613</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872511.1">
        <property type="nucleotide sequence ID" value="XM_007874320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQL0"/>
    <dbReference type="STRING" id="1069680.M7NQL0"/>
    <dbReference type="GeneID" id="19894311"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00613"/>
    <dbReference type="eggNOG" id="KOG1477">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016552_2_0_1"/>
    <dbReference type="OMA" id="ANIKKWG"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12910">
        <property type="entry name" value="SPRY_SSH4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="6">
        <location>
            <begin position="74"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="349" mass="39234" checksum="407111EFB5AEE01B" modified="2013-05-29" version="1">MSFHLNENPYISTLSSSILILFLSFGGILGVFVIVFIIYHINGHCHNSIFLGHGNSEQHEDLIHEEAVLMQTANEEEIESYFRAKAFQEANPPGSMLTDISLSQFMSIQEKGVSAWEFEAFFENMNCFVESRTEITFYDSECSVQTNLPIPKTNEIYYWEAKLYDFSDNTIVSIGLTTKPYPLYRLPGWNKYSIAYVSDGSKRHNQPFSGKPYGPVLKQGDVIGVGYKPRTGTVFFTRNGKRLEDAAQLLKTNLFPTIGASGPCQIHVNFGQYGFVFIEANVKKWGLAPMVGTLAPPPAYQSALLTPPAYQDSLSRYYQGQHDFSNRNIIVTDPSGVPRDNENIISILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQM4</accession>
    <name>M7NQM4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE affecting a late Golgi compartment protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_02153</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Golgi apparatus</location>
            <location evidence="9">trans-Golgi network membrane</location>
            <topology evidence="9">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874134.1">
        <property type="nucleotide sequence ID" value="XM_007875943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQM4"/>
    <dbReference type="STRING" id="1069680.M7NQM4"/>
    <dbReference type="GeneID" id="19895846"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02153"/>
    <dbReference type="eggNOG" id="KOG3202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061883_0_0_1"/>
    <dbReference type="OMA" id="EHDPYRF"/>
    <dbReference type="OrthoDB" id="546861at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21442">
        <property type="entry name" value="SNARE_NTD_STX6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15851">
        <property type="entry name" value="SNARE_Syntaxin6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.90:FF:000004">
        <property type="entry name" value="Syntaxin 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000006">
        <property type="entry name" value="Syntaxin 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015260">
        <property type="entry name" value="Syntaxin-6/10/61_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09177">
        <property type="entry name" value="STX6_10_61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="148"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR09567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="240" mass="28430" checksum="A87ECDD97C1D9FBC" modified="2013-05-29" version="1">MEKIEDPFFEAKEQISFQLSKARYLYDLYFKTVKEKNIGSSTTLLDISNELWKIINEIDDCLIDLEEVVCAVESQPKKYKISDEEASERRLFVNRVRNDLEQMQKDLNDPIEDLSYRKDELLKQTVRDEESLNNSLVMSPKLALKYRKLLEDEQDIQLDHVFGTVQNLREQASIMGKELEEQFELIEEVDMRIERTGEKLKQGFKNMKWVIKRNEDTISSYCIVFLIIILIVLLILIFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQQ3</accession>
    <name>M7NQQ3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02176</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874159.1">
        <property type="nucleotide sequence ID" value="XM_007875968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQQ3"/>
    <dbReference type="STRING" id="1069680.M7NQQ3"/>
    <dbReference type="GeneID" id="19895869"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02176"/>
    <dbReference type="eggNOG" id="KOG1991">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004196_0_0_1"/>
    <dbReference type="OMA" id="WVAKTSW"/>
    <dbReference type="OrthoDB" id="760868at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000244">
        <property type="entry name" value="Nonsense-mediated mRNA decay protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF18">
        <property type="entry name" value="D-IMPORTIN 7_RANBP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="22"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1016" mass="119288" checksum="023128C362E08A85" modified="2013-05-29" version="1">MEELCNVFVATLSSDPNVRKDAESQLKHFSTVSGFIGVVLDVIMTNDDISIKQAASIYLKNRIGNSWEGSNFDYKISENDKDLFRKRLLPTLLLVPPIIRSQIASIIGIILSSDFPEKWTDFMDQVIQLLNSQDIHYIYIGLISFLEISKVYRYRSGVRRKPLNIVVQTAYPRLIEIGNRVAGENDSIAFEMLKIILKCYKFHITLELIPYIQDSIAQWVTLFLFVITRDFPIDSMENNFENCQSSSWWKAKKWAYSNLNCLFTKYGEPSKLSKDTLKKYKSFAKIFSENFTPEILKVYIRQVELWNEGRICISQRCLCFLSTFFEECIFPKSTWILIKDKYFYLVSNFIFPLFCITDSDIELWNDNPVEYVHKNSYIFDKFHSPAISVTNFFIALVDNRKKFTFMGILEFINNVLNTYQQVQFEERNSKEKEAALRMIGHISHIVLAKNSPIINMMEDFLVIHVFPEFWSPYGYLRARACEIMARFADIQIKNQNNIVRAYEGIITCFYDSELPVRVEAACALRFMIRHKFVREMIASRIPQVIQQLLNLTNELDIDTLTTVMEKFVEVFSEELIPFSVQLTEQLRDTFLRIVHESENYFADKGCELIEFNYIDDKTTTLMGILNTLATLIWNLEKAPEILSHIINIILPVITITLEIELIDLYAEVFEIINNCIFSLKAVFPVMWNIYELLYKTFKSSGIDYTDEMFPVLYNYILYGREEMISNSTYLSIIYDIIETMFTVEEFTIQDRIHACKLIESVFLNLKGHVDHYLHSFVKMAMNQLTSDMCKLFSYRIHLIEVVISAICYNSLTTLQYLETCGWIEQFFNYWLSDIDHFSRVHDKKLSIVAICSLLSLPIDQIPKFVQKEFLRLFREQLKLFQTLPQAIKNSEAMENSFLDDLEASPKSESWDDINNQADFEDFDKDIEKNHDYLNSFSQEDWLTSTTDDDNYSLEEEPFHTLLDKIDVYALFKDLINEMQQYNQIMYNEITKDLSQEYYLIIQTVINQAYVYTIESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQT1</accession>
    <name>M7NQT1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872580.1">
        <property type="nucleotide sequence ID" value="XM_007874389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQT1"/>
    <dbReference type="GeneID" id="19894380"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00682"/>
    <dbReference type="HOGENOM" id="CLU_157388_0_0_1"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR11083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="108" mass="12279" checksum="A84BF468F2B9CE5E" modified="2013-05-29" version="1">MPSVFVSKDGTILTEKPFSARLNDIAHQIYLIFMLYLSTLFTFDPQKGIEKYHLKQNTQRTTNTSSNRFSNNRKTWGYDSSNERPLGRRLGSIDDIRLPPCGSCCGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQX8</accession>
    <name>M7NQX8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_02103</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
            <location evidence="9">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the nucleoporin Nup84/Nup107 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874085.1">
        <property type="nucleotide sequence ID" value="XM_007875894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQX8"/>
    <dbReference type="STRING" id="1069680.M7NQX8"/>
    <dbReference type="GeneID" id="19895797"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02103"/>
    <dbReference type="eggNOG" id="KOG1964">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MAHIVLF"/>
    <dbReference type="OrthoDB" id="3098at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140599">
        <property type="term" value="C:mitotic nuclear bridge midzone membrane domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3450.20:FF:000001">
        <property type="entry name" value="Nuclear pore complex protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6 9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR09516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="781" mass="91456" checksum="848773A9011E26C6" modified="2013-05-29" version="1">MKYSSNDMNVEKIEKSSIVDERIESTIVLGKEFEEYAIIFDKYKDIEIFGETGLLSKYYMYGQKRLDTLIESEIDDNCPEIEQWDLECKTWDLIQRLYSHRVQKSHELPNVHEYSSNVVLEEAFYIQNPDAMENTIILNWLKDIFLEPSLLEISGKKWLYTRENIRMKRLQGKSFKEDELIDELDPDAPTRQRKFLDDRDSEFERKFLRNLFLLIRCGDFDKACDLCKDTGNFLRSAILQGCIEYRDPLIDENNVEMGVMGTKRKQLWKKMCYQLSKQTDLDPYERALYGVLCGDLQSVLQVCETWEDYLWAHYNSICEYQITMNLKQLGKIKQSHDLVIPNIDSISISSVLESLAHSDNELIRNSANEPMRIIQSNIITSRIDELILNLNIQLQDIRNGISSVDVTSIPSFLRFVVHFILLLKQTNVSVDHNNCNNLIQAYIELLAAGGKQDIIPLYVAQLPRDMSLEIYAKFLSNIDDDQERINQLRLSSKYKLDMLNSLRRTVDIVYSEALIKDDIFSPFTGELVPITESPSEWDLHQIRALEWMKFSEDLKYDIIFKGNILYRRFLLKGKLNAAQALNLRLSSSILITRDMVKSEDSPGNDKKFRHAVEYLGYSSLCTGYMRYENWKNIMSNGQNEIKNRTDFSGRRQWKLNLQKAVEECASTFHEFIQGNWLYPDTLFTSEAEDPIVYNELIKIRNIYIPDLVCLLHKVYYETYTFFPRNLLACMELCCIVADDDKKIYQTFLLSQRMPEYLKMVRRASIAMLASHNKSKPSLWNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NR43</accession>
    <name>M7NR43_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA(His) guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.79</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA-histidine guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PNEG_00781</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 5'-end ribonucleotide-tRNA(His) + GTP + ATP + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54564"/>
            <dbReference type="Rhea" id="RHEA-COMP:14193"/>
            <dbReference type="Rhea" id="RHEA-COMP:14917"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:141847"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.7.79"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA(His) guanylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.79" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872684.1">
        <property type="nucleotide sequence ID" value="XM_007874493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NR43"/>
    <dbReference type="STRING" id="1069680.M7NR43"/>
    <dbReference type="GeneID" id="19894479"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00781"/>
    <dbReference type="eggNOG" id="KOG2721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044271_0_1_1"/>
    <dbReference type="OMA" id="NYMIKSV"/>
    <dbReference type="OrthoDB" id="62560at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008193">
        <property type="term" value="F:tRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3000:FF:000001">
        <property type="entry name" value="tRNA(His) guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025845">
        <property type="entry name" value="Thg1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024956">
        <property type="entry name" value="tRNAHis_GuaTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007537">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038469">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729:SF6">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04446">
        <property type="entry name" value="Thg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14413">
        <property type="entry name" value="Thg1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028980">
        <property type="entry name" value="tRNAHis_guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNAHis guanylyltransferase catalytic" evidence="16">
        <location>
            <begin position="6"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Thg1 C-terminal" evidence="17">
        <location>
            <begin position="138"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="29"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="75"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF14413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMR11188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="183" mass="21734" checksum="3181291C2EF24D47" modified="2013-05-29" version="1">MANSKYEYVRNFEKHDKLLPNTWIVIRLDGNGFHKFSNKHNFEKPNDIRALNLMNDAATSVFLKFPDIILAYGNSDEYSFVFRKTTQLYDRRESKLITSIVSFFTSNYVFLWPNYFFDTVLRYPPSFDARIILYPSTQNLRDYLSWRQVDCHINNLYNTTFWALVQKGKLSTTDAEKMLIVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NR63</accession>
    <name>M7NR63_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="3">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Nuclear thiol peroxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_01927</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873903.1">
        <property type="nucleotide sequence ID" value="XM_007875712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NR63"/>
    <dbReference type="STRING" id="1069680.M7NR63"/>
    <dbReference type="GeneID" id="19895621"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01927"/>
    <dbReference type="eggNOG" id="KOG0855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_14_1_1"/>
    <dbReference type="OMA" id="HQAFTQK"/>
    <dbReference type="OrthoDB" id="338622at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03017">
        <property type="entry name" value="PRX_BCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000157">
        <property type="entry name" value="DOT5p Nuclear thiol peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050924">
        <property type="entry name" value="Peroxiredoxin_BCP/PrxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801:SF23">
        <property type="entry name" value="PEROXIREDOXIN DOT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="13"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR09742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="159" mass="17704" checksum="B6DED5D752D7780A" modified="2013-05-29" version="1">MPINTERQALKAIQLGDKLPDIVLKNELGEDVYIQKIAEEHPIIIFAYPKASTPGCTVQGCGFRDNYETILSKNYHIYGLSMDTPKAQLNFKTNQNFPYHLLSDPKAELISALGASKSGLKIARSHWIFEKGGTLLDMKIGVSPKDSVEKVMAKILEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRS1</accession>
    <name>M7NRS1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01969</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873947.1">
        <property type="nucleotide sequence ID" value="XM_007875756.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NRS1"/>
    <dbReference type="GeneID" id="19895663"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01969"/>
    <dbReference type="eggNOG" id="KOG0298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001592_2_0_1"/>
    <dbReference type="OMA" id="KAVFFCA"/>
    <dbReference type="OrthoDB" id="5330228at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18070">
        <property type="entry name" value="DEXQc_SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052583">
        <property type="entry name" value="ATP-helicase/E3_Ub-Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059033">
        <property type="entry name" value="C144_05_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26021">
        <property type="entry name" value="Ferritin_C144_05"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="296"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="1070"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="1172"/>
            <end position="1332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1372" mass="160048" checksum="731F22A0D35CB711" modified="2013-05-29" version="1">MLIISSDQQNFINTDAILRDVVKEDNNELASQKKQVESSEEAVLIRFKIKLEILSDELWENFVKEKRDLLKLVVSDILFILNESLLHLINYGSKSILAAYVCSEKDLEILLPIYELVFGIRSSENEPIYGKLIKHYFQTHETLRFIELENKWYFLIELCISMRYVNVFSIENLKMFQKRTRYGKSLISELMHYAFPSTLEIQDTINPSLFYDNVYGLPESKISSFISPDKLNTNLLPFQKKAVEWMLKREKCIPNTLDYGKDNIPPTWEASIDVDGKQIYYNKVYGIICSSIIDVKNTFTDIDGGILAEEMGLGKTVEVIALILKNEKKKISESEKVFDSYTESYVIASKTTLIITPISILQQWITEFSKLAPHLKVLHYVGLKNLSSNLSIKDLIEYDVIITSYNVLSFEIHHTKLMPERSLRYGKKYIPKLSPLVQIQFWRVCLDEAQMIETGVSNASLAALSIPRVHAWCITGTPVRNSLSDLYGLLLFLRFYPFNCNKIWKRLIDDPRNASAFVSLFKLITCRHTKKYIGDQVILPKQERIILLLDFTPIEEHNYSFLLKQALEEIGFNDQKNPASIDWNFNDFKDKMRHWLLRLRQTCCQMQVGTVNKMNLGGQLIMLSEALNVMLKKVNDTIDNDERSLYTLKFTIGRLYESKNKPQEALDIWLPILKIVQDKMELFEQEIEKIRQHSLIDSKNEIKNSIDTIDENTSTNYYSTEEKKTPIKSIQTHIRHWRSLAHRLTFFIATAYYQLGNKEKEDEYYSKAEQIRREILSETESKALFLMKKLSQRAENDDFITIPKLNLSEIINNIHSSHNKSLLDIIKKLNNQAEKINEWRQKIIKLSLCALVDHNENVTGEEYIKSLDIMEDAYQYLEALRSAIASRIETLNGEKSFLTIVETQSRLSSQQTQLRHQLTYITEELRPTPSLSLKSIIDDLHISKQINDTNIEGKKYRKIQNISNFETYRLPEILKNEIKITVKLEKEISDLSYLHNARIEYYRQLQIISDYVAELDEELLEPQNYAKKMKELDEKIKSYELTIHSNQGRLRYLKYLSKISSNKSEMDEICVICQNIFDFGILTECGHIFCKFCMMRWLTEHQTCPSCKTEIKETNYYNIVHNSSKTNNILKDPNIYSLNHQDSKKKYNEFNKMFLEIKNIKLKESYGVKVDMIVKHILWMRKGDSIGPKSVIFSQWKEMLDILHHAFTNNGIKFSRLDTVITKSKKKGNIENDPVARFKNDNSIEVFMLHARSQSAGLTLTNATNVFLCEPLVNIAIELQAISRIHRIGQNKQTFVWLYIIRGTIEEKIVKLTEKKRAQFAERYNNTSKNLYDNSNLNDLSEKELQKNINKLTDTTGEIIENNALLYLWGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRT0</accession>
    <name>M7NRT0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873957.1">
        <property type="nucleotide sequence ID" value="XM_007875766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRT0"/>
    <dbReference type="STRING" id="1069680.M7NRT0"/>
    <dbReference type="GeneID" id="19895672"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01978"/>
    <dbReference type="eggNOG" id="KOG1018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051532_0_1_1"/>
    <dbReference type="OMA" id="HEEINIF"/>
    <dbReference type="OrthoDB" id="2529286at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR09796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="266" mass="31089" checksum="6A419CDE397A682B" modified="2013-05-29" version="1">MEPDSNILESIDIDEHCIVKFSNINNVEKKGLGYYSIIESTLTLCIANKQFTIRQNPNIFHCNKEDTGCVLWRASVVCLEYLLSQSWFVCNLQDFQVIELGAGISGIGAILLGEKVNKYIATDKEHILKYLYRNIRENLPIKSNIKKKQSTHEEINIFVMELNWFESPNTYLKNLQSFLGKTSKHLCILAFDTIYNPYITIHFVNTLLSIFDYFQERKIFAIIGLELRNYDTLYDFLEKIQSHFFIQAICDEQLQKGYQIYFIQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRT7</accession>
    <name>M7NRT7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Small nuclear ribonucleoprotein E</fullName>
            <shortName evidence="11">snRNP-E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Sm protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_01987</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873967.1">
        <property type="nucleotide sequence ID" value="XM_007875776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRT7"/>
    <dbReference type="STRING" id="1069680.M7NRT7"/>
    <dbReference type="GeneID" id="19895681"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01987"/>
    <dbReference type="eggNOG" id="KOG1774">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125186_1_0_1"/>
    <dbReference type="OMA" id="VPPINCI"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990935">
        <property type="term" value="F:splicing factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036261">
        <property type="term" value="P:7-methylguanosine cap hypermethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01718">
        <property type="entry name" value="Sm_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000031">
        <property type="entry name" value="Small nuclear ribonucleoprotein E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027078">
        <property type="entry name" value="snRNP-E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11193">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="18"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR09806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="92" mass="10710" checksum="F86EAAA51D97629A" modified="2013-05-29" version="1">MSVRTQSGRTQKVMIPPINFIFKLLQQHIDVCIWLYEQIDIRIEGKIRGFDEFMNLVIDEAIEVAQKKNSRRQLGRILLKGDNITLIQAAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRU9</accession>
    <name>M7NRU9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_02002</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873982.1">
        <property type="nucleotide sequence ID" value="XM_007875791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NRU9"/>
    <dbReference type="GeneID" id="19895696"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02002"/>
    <dbReference type="eggNOG" id="KOG0939">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000215_0_1_1"/>
    <dbReference type="OMA" id="ADEMKYG"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120113">
        <property type="term" value="P:cytoplasm to vacuole targeting by the NVT pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000004">
        <property type="entry name" value="E3 ubiquitin-protein ligase HUWE1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010309">
        <property type="entry name" value="E3_Ub_ligase_DUF908"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010314">
        <property type="entry name" value="E3_Ub_ligase_DUF913"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF67">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06012">
        <property type="entry name" value="DUF908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06025">
        <property type="entry name" value="DUF913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBA" evidence="13">
        <location>
            <begin position="1231"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="14">
        <location>
            <begin position="3256"/>
            <end position="3592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1996"/>
            <end position="2032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2067"/>
            <end position="2212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2464"/>
            <end position="2530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2604"/>
            <end position="2631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2937"/>
            <end position="2964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1997"/>
            <end position="2009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2067"/>
            <end position="2086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2095"/>
            <end position="2113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2133"/>
            <end position="2143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="2154"/>
            <end position="2172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2175"/>
            <end position="2212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="2604"/>
            <end position="2615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="2617"/>
            <end position="2626"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="3559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR09821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="3592" mass="409780" checksum="FAE2C6F77584FD3A" modified="2013-05-29" version="1">MKIKREVPKKISQLPVELKEVIDQASEASEEELPTLLNGFQEWKYARGDLFHWVGLLNRFDGIFERICKEYALKNVQTVAFNSKTKELVITILRFSTILLDNCSNRNIYNSCNYLNDLLYSTDIDVVEHTLSLLLRLAQRVSSQRYYRSNYSISSERCLKLSMSLQQSSQERGTSEIDMFKLLSDSYLADGCKNVYYAFYRHLNPVEAIALVSNSKDKEAQASTPTNKSKMKENSFSPVESVDDLLEGMTVVKISFEKFYNRQLEDILNDVISTYNIPAVNHFDLMLRIRFARYVHDKKKRQQLVCIKILAIAVLAYTVQEHILHSRFFIYEPDITTNLAYLIHPDNKISKEIELVAFYALEALAHHRPKLMDVLSALNASVNHGVLMYVFRTMIVEMENPTSTKTFSKEYVDALFLLIHYLTTTQQGGNMLTSAGIILSLIRLLKNKAPKAIRAVTKATSLLDHLTYGFPSTFNAFCSARGLDVLVERIKDEVNYNIKQFSLSDKASKAVLEHSMSQERFIILKTMLKFTLHMMQSTGTSDGLRNLIDSPLLETLKNIFTYFEDFGSSIITMSINIFSTFIYNEPTSYSIIHEVKLSEMFLKMTSSLILPSADVISAIPSAFGAICLNTQGMELFNSIKPLPFFFNIFTSSLHRKVLQDSQISDILGASFDEFVRHHPSLKSDVIDEILSMLKRVLEMGSELMSVIHNPNMLVTSTYNELNSQNGQNDVVMKEKNDYIEEDERGVKRLIIIWHIDFVSRFLEGFFQNSSHCREFLRNNGLNILLQHYTIPCLPYDFIDTCAAYSLSHLFRTISEVNVQNVLLDIMKHFQKSLSKLDILLEHKGIECFFERYLKILPSGLEFISEGDEFLKSLSQIHDLSSLLSDIYELPIFSHARSAFSFFQLFLSNPELDGLLEKIGHLVRVCVWENIRLLNVMPNNWEEATRLSDDLKIKTNDKEKKDLKSDKLIDKDSETFLNVKIMRYLLVQIPTSLNNFFQGLTKMLITHRFSDSGQRKTALKVANIIGTILARHLKWEKLDDVEHINNKYMYWTTILGFNQVVMLEEKQQLSVQTIVLVAFDKSGGIQVMLQILKIFWQEADKLSSITEVSDDIRSITSRVYDGIKIILHFFKAITLPKALLTSLQTVGLSSREKDKEKPDYFNSNEFIVRLRSSIFPSIKDLWFSDILYKMPYLNAKSLIQILSQAFKTDGELSEKAENSTSLVSFNHRALSGPSEDRIRQLCDMGFIRSAAETALARCGNHLSTATEYLLAHPELNQDAGTSGSHGNSYLSSNYAVSSQNEQINNSLRDASTDINQDPSFISLLNPSNSTEQNIFSNEENSDRTFSNLNVVKRSEMNPLSMKGKGKDILKMSIRSHLIERTLLLLNIHNNLVFELSGLILEAFAYSNENSWSIYVVQSIVNNIRALESKFKLSESDGLQASSILHFLGLLIHDSSFYESCKDEILNHQEIFIRFLTYENDKPSPWIAPALLVFEQIIIASIQPKQQPPFSVNEESIPKVVSNLFFSIEKELIFDSILELFKLEIQKMDDIVSLLRVLMILTRSKDMVNYFFEKNGMHLLFSIIKSISGKHHSEHLQILIITILRHLIEDLNIIYAITTTEIKSYFNQSRFRGLDINAFLRNNTQLALRDPDIFVDVIEKECKLLRYDSHNRVQQIALKDSESFENPVQEITSTDQIPCISKQLSQDEALETNKQEYFNSVIFFLLSELLDCKDSLDHDELKLSEFNVNSDIANFVTNIEQNKTSNTTSKESEFKAEDHPQYMYKCFLLQCLAELLSSYKHCKLEFINFSRNYSFKGIVIPSKIRSIMLSYLLYEIIPYGSINPSENIQIRKKFSTSNWAISVIISLCASTSETLDEKDRPDMIFVRKLVLESISKAFRDASCSLEPLEMRYSRLLTLSELCYRLLVARANIKGTSNHTSDDHKKIAKLMLEKNFMSILTGALADIDLNFPSSRRLVRLILRPLRKLSQIAVELNENSEIEKPGDNTRQDEALTDASISEREPLEEREETPDLYRNSALGMFHGEMEDNEDSNEFDSDDEEIYDEMDFDEEDSETGSVLSDEDNDDIDIGSQQNGEMDVEIILDDQVDTDDDINEQTELGSNDAVEDPNRVSGDEGFDAEIDDESGWQTESEHDPQNNIESRSNQLHSLSSGVQGDNEADADVLIDDDREDQGDDDDDDDDDDDDDDDDDDDDDNAEEALIEEELLPNDIDEIEANGQWGWSSIDDITNDDDDDNGISRSNRRSWLAITSGGCHFISEPNEQAFRRRSRINNMGESGINPLLVDSTNMSQRHILQSRDSFSRSDSFTDWVQSIEQLIGGGAVQVLGDVMNRVSRQIRGPSQHAIRVEVNTGNGSLLTREVERMFGQRSQSVQQNQRSSREDPITAVATWSPTSTSQRWFDEARLIYGSGVVEKALLLLNSLMNVLAPQAIKDEKIRKEKEKMLEEAKKKQEIAGKSVENNSGENRLENELPDNEPEKVGNSTVGSSIMDGVESTSAQAQEPSAEEPSGLPSRVTVMLRGNEIDITSLDIDPTFLEALPEDMREDVLTQHIRDRRVAALTSHSSEISPEFLNALPEEIREELLQQEAADRRRREREQQAHVSRNNSDAPTTGPIEIDPVTFLATLDPYLRRQVLLDQDDEFLSQLPPSLAEEANTLRERSSGRLGQIFQVSASSHQQTSNVTSKKSSVKHEVSQLLDKAGVATLVRLLFIPQPNGKNPLHDILLNVCKNRQNRIEVINLLLSVLQDGTNDLYAVDKSFSQMSLRAKNTSTLKSTPKSKTSKYSLSSFLQSNRENTPNLVTQQCIEALEFLIQWNEYLPSYFLNEHDHIIRPRRSNSRKDKGKDISTKGSKYAINILLSLLDRDSILQNSNIMDQFSHLLSIITRPLIVLKRRGKQDSELYKNAGSSQAQFEINEDIVEEKSEHNADSHDDTDAKSVDNNNKDQDIKNKNRLVLPPYIPENNLRFIVNILTSRDCSSKTFQHTLAAMQHLSIIPGSKDIIGDELVCQAQAFGSKLLGQLDDLIQQIQNASFGIELQGAALSEFSPPSSDQAKLLRILKAISYLFEQKENSQFAEIENNNDLFRLYDSLTFRPLWKKLSACLSVIQERSDMIHVATILLPLIEALMVICKNTALKDISKLPHGSRQTTPSEDSMEYIFFSFTENHRKILNQMVRNNPSLMSGSVSLLVKNPKILDFDNKRNYFNRRLHDRGANREHYPPLQLNVRREMIFLDSYLALYFKSGDEMKYSKLNIRFHGEEGVDAGGLTREWYQALARQMFNPDYALFIPVAADRTTFHPNRRSDVNQDHLSFFKFIGRIIGKALYDNRLLDSHFSRAVYKKILGKPVSLKDIETLDLEYYKSLVWMLENDITDVITETFSVETENYGATETVDLVPGGRSILVTEENKHEYVKAVIEYRLINSVKDQLDNFLVGFYDIIPPDLIQIFNEQELELLISGLPDIDVDDWRHNTEYFNYTASSPQIQWFWRAVRSFDDEQRAKLLQFATGTSKVPLNGFKELEGMQGIQKFSIHRDPTSSDRLPQSHTCYNQIDLPEYGSYEALRSALLTAINEGSEGFGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NS26</accession>
    <name>M7NS26_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01676</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873638.1">
        <property type="nucleotide sequence ID" value="XM_007875447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NS26"/>
    <dbReference type="STRING" id="1069680.M7NS26"/>
    <dbReference type="GeneID" id="19895370"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01676"/>
    <dbReference type="eggNOG" id="KOG4134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105516_0_0_1"/>
    <dbReference type="OMA" id="SKMPRIN"/>
    <dbReference type="OrthoDB" id="10250504at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041178">
        <property type="entry name" value="RPA43_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17875">
        <property type="entry name" value="RPA43_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RPA43 OB" evidence="7">
        <location>
            <begin position="131"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="229" mass="26879" checksum="8B65601AECE36A6C" modified="2013-05-29" version="1">MSGEDKRFKKRSYNEVDNDNMSKENKKKRKKNESKVKKKELFKKSILKPKNPFYKFEIESYISIPPIYCGSPMKGVEYYLDTMILNYLPNIQGIMLAHRNCEFIDRTAKIYYESPFGFSWIRFEMLVWRVKRGDYLEGIINLQSPSHIGLLVSGFFNASIPKNGIPKTWSYQEIMSQKEVEQNKNGYWMNEDKKAIKIGDKLCFWTVKLETIGGIVSIEGTIDIEKIHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NS99</accession>
    <name>M7NS99_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable cytosolic iron-sulfur protein assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CIA1</name>
        <name evidence="5" type="ORF">PNEG_01422</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat CIA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873361.1">
        <property type="nucleotide sequence ID" value="XM_007875170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NS99"/>
    <dbReference type="STRING" id="1069680.M7NS99"/>
    <dbReference type="GeneID" id="19895119"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01422"/>
    <dbReference type="eggNOG" id="KOG0645">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_8_1"/>
    <dbReference type="OMA" id="IREIRWS"/>
    <dbReference type="OrthoDB" id="284782at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03037">
        <property type="entry name" value="ciao1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028608">
        <property type="entry name" value="CIAO1/Cia1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="10"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="53"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="103"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="148"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="192"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="255"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR10147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="341" mass="38853" checksum="0DE359FBCAB3A4D9" modified="2013-05-29" version="1">MKYLRHIQTLSGHVDRVWNLSLHPTLPLLASASSDKTAKIWSTQNGRCIATLEGGHQRSIRSVSWKPQTKGDIILATASFDGTIGIWEPDYENKSEWECMATLEGHESEVKSVNWSSDGGLIATCSRDKSIWIWEAEEENEFDCLSILQEHTQDVKMVLWHPKEERLASASYDNTIKLWKDNQDDWACYANITGHNSTVWCIDFEKRSFDPRLVSSSDDQTIKIWKREPRTQDYSNIAPILVPFEETWIEQTTLPKVHTGTIYSVSWSGTSGRIVSSGSDGNLVIYEENKEGWTIQAIQKNAHDVYELNCSIFCNISESEYIYTCGDDGNINVWELESTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSB5</accession>
    <name>M7NSB5_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01767</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873733.1">
        <property type="nucleotide sequence ID" value="XM_007875542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSB5"/>
    <dbReference type="STRING" id="1069680.M7NSB5"/>
    <dbReference type="GeneID" id="19895461"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01767"/>
    <dbReference type="eggNOG" id="KOG4524">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QKDIRHE"/>
    <dbReference type="OrthoDB" id="49511at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052587">
        <property type="entry name" value="TELO2-interacting_protein_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057567">
        <property type="entry name" value="TPR_TTI1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057566">
        <property type="entry name" value="TPR_TTI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049362">
        <property type="entry name" value="TTI1_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460">
        <property type="entry name" value="TEL2 INTERACTING PROTEIN 1 TTI1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460:SF3">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24181">
        <property type="entry name" value="TPR_TTI1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24173">
        <property type="entry name" value="TPR_TTI1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21547">
        <property type="entry name" value="TTI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TTI1 N-terminal TPR" evidence="1">
        <location>
            <begin position="10"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="TTI1 C-terminal TPR" evidence="2">
        <location>
            <begin position="824"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1034" mass="118747" checksum="6D5D909DF056A4DF" modified="2013-05-29" version="1">MNIKSNLSAFSKLKPICMRLSCVWTDSNLQPDVYVSLEALYKVLSSFSSEELLGCTISDYVFLPLSHLWRGYLNLDDRLKEGLLRCTNELIRIGWGVEMSDALFKQLCMLLTGFIKPMSGLERNLPEDLCLEGLEGLYMLFKCKKECRKCLGNDEKELDDGLIAIIGYTISVLLEIYEKTLWNRLQNKCVDVLQVFLFEVVEDKSVLRRFLPGIMSCVCQLVVNGKVKYSRAIIASVVLSRRLLETCFADDSLEEVVDRVEVKKMDQKMSLDHIRNMLSVDSNVLEVNKDVSKVSDNTLEGRAPIGSEEWLMNTRERVYTVCNILLSLKAHSNRQVRQEILEFSIGVFNTCFKTLCNCIQLLLSTILFLAGDLEESIQNISVKFLFQLEEQKYSEQEFEDVINMLLKEYLDAWPRLNLLSDEDAKRHHLIAMMHIVSFLSKRNLESSFVFDFLIHRISDSLHFATDTKILKKTDLIQPLFYFNIQDLSDSHIYSGLKFPVFRFENIENNLTFFALENLFAIFGKYSTIKFFNSLLYKIKTSTYEPRTNILRWIFLCNLRRMIHDSSFQHDQNIDVNMERIYMNVYTDSLNYISEFSSHMYDEAMNWNVPQDKVVHICLDLEIISLIAKKLGKQFRIEFVDCLYPIVYLLGSRCEAIIQHARICLNNLAVYCEYDSIQDLLIGNVDYLINAINLKLNTFDVFPTGPVVLIILLRLVGPTMVPYLEDVVDSVFAILDNYHGYSNLVSVFFSFLNEVVRINGIVERPKISQVVEDDIHSAGPCLEVMQIVTKIRSLYHTDATEIMGTTFDSLNHSTSSENLSNNMNKVTLKIIQKISNKSQMFLNHQSSNIRNELLKMLSVSIPFLASDERSFLPFVNDIWPLIIGQLNLNEMTSIITSSLNVITLLCVYAKNFMTSRLSKHGIKILCNLLNTSCQQDILGIADKFSRSVSIQNGIFAAFDAAIENVKLPDKCVDKIIESVISFLKKPSKGLEIEALKKTLEKRHPDKLWLSMLPFTNFKANIPVSKDNFLFPDIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSK2</accession>
    <name>M7NSK2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Negative regulator of the PHO system</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Serine/threonine-protein kinase PHO85</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PNEG_01380</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">When phosphate concentrations are high it phosphorylates the PHO4 transcription factor thus establishing repression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with a number of cyclins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873315.1">
        <property type="nucleotide sequence ID" value="XM_007875124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSK2"/>
    <dbReference type="STRING" id="1069680.M7NSK2"/>
    <dbReference type="GeneID" id="19895077"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01380"/>
    <dbReference type="eggNOG" id="KOG0594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="OMA" id="NWQIFVP"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07836">
        <property type="entry name" value="STKc_Pho85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000062">
        <property type="entry name" value="PHO system negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000410">
        <property type="entry name" value="Probable PHO85-cyclin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF46">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="5"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMR10101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="297" mass="33629" checksum="019534F61D30EDE4" modified="2013-05-29" version="1">MTSNYQQLEKLGEGTYATVHKGRNRATGEIVALKEIFVDADEGTPSTAIREISLMKELKHENIVGLWDVIHTESKLMLVFEYMDKDLKKYMDSQGNGGALDPNIAKGFMYQLLKGIAFCHDNRVLHRDLKPQNLLINKRGQLKLADFGLARAFGIPVNTFSNEVVTLWYRAPDVLLGSRTYSTSIDIWSAGCIMAEMYTGRPLFPGSNNDDQLLKIFRLMGTPNEHTWPGISQYPEYRANYPVYNVQDLSQIIPQLDPLGIDLLNKMLQLQPNMRISASNALKHAWFTDVSYPSHNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSS8</accession>
    <name>M7NSS8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 14">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_01578</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 14"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873532.1">
        <property type="nucleotide sequence ID" value="XM_007875341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSS8"/>
    <dbReference type="STRING" id="1069680.M7NSS8"/>
    <dbReference type="GeneID" id="19895273"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01578"/>
    <dbReference type="eggNOG" id="KOG3187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034302_6_1_1"/>
    <dbReference type="OMA" id="WSYILWQ"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR10322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="206" mass="24629" checksum="67522B58009FAB4A" modified="2013-05-29" version="1">MNILYNMKAARNKKLLNYLFLYNIFSCFGWISIFLYTFFIQKNSLIDYHYKQLIFLLKYVQTFSVLEIVNACFGITSSPVFTTILQVSSRLLLCWGILNLYPSIVLKTTAFFSMIYAWSITEIVRYSYYASNLKKKAPSMLLWLRYNLFYILYPLGTSSEILLIWKTLPYIDHEKHVYALILKGILMIYIPGFYIMYKHMIYQRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7NT29</accession>
    <name>M7NT29_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CHY-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01515</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873456.1">
        <property type="nucleotide sequence ID" value="XM_007875265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NT29"/>
    <dbReference type="STRING" id="1069680.M7NT29"/>
    <dbReference type="GeneID" id="19895210"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01515"/>
    <dbReference type="eggNOG" id="KOG1940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140539_0_0_1"/>
    <dbReference type="OMA" id="HQEQESH"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052604">
        <property type="entry name" value="Mito_Tim_assembly_helper"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082:SF2">
        <property type="entry name" value="CHY-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="119" mass="14126" checksum="E831C175B131C09E" modified="2013-05-29" version="1">MCKHILNAQVSIRATCCKRWFDCSECHLEVSDHVLLKSDEITFICKKCKKAFRKNIRSFEDESDEYCPHCDNHFLIEAITPKPALTIETEDVRRDNRVIKDYRERQYGNRSIFPSRNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7NT87</accession>
    <name>M7NT87_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen2</fullName>
            <ecNumber evidence="4">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01544</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873491.1">
        <property type="nucleotide sequence ID" value="XM_007875300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NT87"/>
    <dbReference type="STRING" id="1069680.M7NT87"/>
    <dbReference type="GeneID" id="19895239"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01544"/>
    <dbReference type="eggNOG" id="KOG4685">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012847_2_0_1"/>
    <dbReference type="OMA" id="YSHPYWK"/>
    <dbReference type="OrthoDB" id="10249562at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032473">
        <property type="term" value="C:cytoplasmic side of mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016589">
        <property type="entry name" value="tRNA_splic_SEN2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00324">
        <property type="entry name" value="endA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011789">
        <property type="entry name" value="tRNA_splic_SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="6">
        <location>
            <begin position="226"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR011789-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="348" mass="41510" checksum="5B9A14C20C8ADD9A" modified="2013-05-29" version="1">MRDPPLPLTLPFFPHHPVSIIWLLYKIYKGFQPQRHYKGILDVATASVWVTDASTIDQLWRCGYFGKGNLSRSTLTWSKRIQRLFGWVSSNEDLTTEERTQQRRQERLEFKHQRGLIEMEAIDRIRIEEGKEKQNIIEDNRRITRRENYTRIEAKKTEKLEKSISELEHLQLHLEEAFFLSYSLGILDIDVSKYFSIKNSMELLLLFCSLSSIPKTENEIDVDNSFLISYVVYHHYRSLGWVVKKGLKFGVDWLLYKRGPIFSHSEFAVIVLPFYPDNRKKELSWHWLHCINRVISQVKKTIVLCYVQIPYETVFKDAIQTKRIDLILKKYKIREISVKRWQPSRNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTI8</accession>
    <name>M7NTI8_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873226.1">
        <property type="nucleotide sequence ID" value="XM_007875035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTI8"/>
    <dbReference type="GeneID" id="19894998"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01301"/>
    <dbReference type="HOGENOM" id="CLU_990859_0_0_1"/>
    <dbReference type="OrthoDB" id="5386619at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016071">
        <property type="term" value="P:mRNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028322">
        <property type="entry name" value="PNRC-like_rgn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15365">
        <property type="entry name" value="PNRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="281" mass="32332" checksum="5282B70831A7C917" modified="2013-05-29" version="1">MKTRKQKLARKVISDNKYEKQDSTNWQFFNANVQSPETELINDSMSHKLSITPHKESSHYAGPTFHHSPAASNLPIPSFFSKITYNTPHLQPLHFHQSSQDIQTSAPRGLCSSTQDTFFDTNSPSLSQIHSFKPLEQTSEKSLYGPSIPLSHEVHSSSPKMLFQADMNERKQKQALRKQETSDSSDFNDTFYSKTYSSIKKVGKKKEIKENTLLSLYSDFHNMQRNQKDSYQKTTFYKKNKTQLRNNMYVDNYNSNIEDMKEKLLSLLLPSPKSNKSSANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTR2</accession>
    <name>M7NTR2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar protein 58</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01361</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for pre-18S rRNA processing. May bind microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873291.1">
        <property type="nucleotide sequence ID" value="XM_007875100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTR2"/>
    <dbReference type="STRING" id="1069680.M7NTR2"/>
    <dbReference type="GeneID" id="19895058"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01361"/>
    <dbReference type="eggNOG" id="KOG2572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015495_5_2_1"/>
    <dbReference type="OMA" id="MGMRSNW"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017069">
        <property type="term" value="F:snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902570">
        <property type="term" value="P:protein localization to nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000003">
        <property type="entry name" value="Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000001">
        <property type="entry name" value="Probable Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="284"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="457"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="501"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR10662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="512" mass="57652" checksum="4B39845B0F828135" modified="2013-05-29" version="1">MLVLTETSAGYAIFKFSAKEKVFKKPEILYKSLDTLDKATSLLKLKVFSKFENIVEALDNASAIIEGRVTGKLASLLSEFSGKKDSLIVSDLKLANSIKKLPDLNISIVFDPSVQELYRVIREHITSLISELTPTDMSDMVLGLSHSLSRHKLKFSPDKVDTMIIQAIVLLDDLDKELNIYVMRIKEWYGWHFPEMSRIVLDNIVYVKVIKAMGHRTMAEEIDFSEILPEDIEISMKAAARVSMGTEITDDDLENINLLADQILSLAEYRIQLSEYLRNRMEVVAPNLTALVGELIGARLIAHAGSLLSLAKQPASTIQILGAEKALFRALKTKHDTPKYGLIYHSSLIGQASSKNKGKIARILATKAAISLRVDAMGEKDIATIGIENKLKVEARLRALEAERLEKFSTSSEKLWKKHQIQITPKYNTDTDIVIDTSLKEEYPQVKIKKSPPEVELFEDLKTESSKGKKKDKKDKSKKEKKRKMSEIENTGATTESYDKSKRKKIKDKSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTT4</accession>
    <name>M7NTT4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aspartyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_00833</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872742.1">
        <property type="nucleotide sequence ID" value="XM_007874551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTT4"/>
    <dbReference type="STRING" id="1069680.M7NTT4"/>
    <dbReference type="GeneID" id="19894531"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00833"/>
    <dbReference type="eggNOG" id="KOG0556">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_1_1"/>
    <dbReference type="OMA" id="WVHEIRD"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000013">
        <property type="entry name" value="Aspartate--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000132">
        <property type="entry name" value="Aspartyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="246"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR10682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="558" mass="64913" checksum="CC1FC62E00E13FE5" modified="2013-05-29" version="1">MTDLFMNEKDNTYISRPVLDYRGDSLEESKKLVSKKAQKKLQQKEKKKERLLSSNIENKVSCDDFSKENYGKKKINQSLEKLGTEFHSISSLSKIMEGKNITLRARVQVSRLQGNKICFLLLRQHLNTVQALVSANKNSISKQMVKWCSLIASESIVVVEGEIKKSPCIIKSSTQQDIEIHVRKIFIESESLNKLPFQIEDASRSENEIKEKDDYKDDLKYVRVNLDTRLNNRVIDLRTFTNQAIFRISSGICQLFREYLLENNFIEIHTPKIIAAASEGGSNVFKLDYFKGDAYLAQSPQLYKQMLIASDFDRVFEIAPVFRAEDSNTHRHMTEFVGLDLEMTFYEHYHEVLEMIENLFIYIFKELPKRYSDEIHIIKKQFPSSDFMFLKDNKPVRFTFKEIVNLLKEAGIRKNKNGEEYHIDLSTDEERKLGLLIKEQFHVDFYSIDKFPLTARPFYTMPDPENPSLSNSYDFFMRGEEILSGSQRIHDAEYLQKRIKDLNINTIGLENYINSFKFGTAPHGGGGIGLERVLFLYLELGNIRRSSLFPRDPKRLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTZ7</accession>
    <name>M7NTZ7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873220.1">
        <property type="nucleotide sequence ID" value="XM_007875029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTZ7"/>
    <dbReference type="STRING" id="1069680.M7NTZ7"/>
    <dbReference type="GeneID" id="19894993"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01296"/>
    <dbReference type="eggNOG" id="ENOG502RYEB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060788_1_0_1"/>
    <dbReference type="OMA" id="KCVEYDP"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815:SF1">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="1">
        <location>
            <begin position="61"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="264" mass="29479" checksum="9A6581BD05FD4C62" modified="2013-05-29" version="1">MATSHETAVGSEISGILGGASEAPVFLKRVSFDTFDNRDARDFSLTLRATHRSYTYSYRSRTFLCGIDQNDYSESALDWLIEVLVEDGDEIIALRVIDPGSRMAAGLSMQEKMYRKDADLLMERILQKNEESKAISVMVEFAMGKVTTTLLHRIHIYQPDSLIIGTRGKGLGLQSLLPGSISKYCLATSPVPVIVVRPDRKREEAKSKRLANPLRQSYVEILEKSNSSMDFRTLNQSTQAEKPSSTIKSHFGIFGGSKYKRLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUR3</accession>
    <name>M7NUR3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial inner membrane protease subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_00982</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S26 family. IMP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872896.1">
        <property type="nucleotide sequence ID" value="XM_007874705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUR3"/>
    <dbReference type="STRING" id="1069680.M7NUR3"/>
    <dbReference type="GeneID" id="19894680"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00982"/>
    <dbReference type="eggNOG" id="KOG1568">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028723_4_1_1"/>
    <dbReference type="OMA" id="WIPVIAW"/>
    <dbReference type="OrthoDB" id="9996127at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037730">
        <property type="entry name" value="IMP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041:SF2">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Peptidase S26" evidence="12">
        <location>
            <begin position="19"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR10836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="183" mass="20946" checksum="9370D66EB7CC4C22" modified="2013-05-29" version="1">MLHHNISIIRVLARQTGIFITWLPVFLFIHDHLIGIGMVQGESMKPTLNPDINGSWHDWVLLKRWGLLRSDGSLDIKRGEVVMIKSPIDPEGYLAKRVLALEGDYVQTRTRAASCVKVPKGYLWIEGDEGFRSRDSNMYGVVPTALVCAKITHIIWPWWRIGRIESGFGRHQRVYSVDNLNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUX9</accession>
    <name>M7NUX9_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Preprotein translocase, SecY subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_00709</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872609.1">
        <property type="nucleotide sequence ID" value="XM_007874418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUX9"/>
    <dbReference type="STRING" id="1069680.M7NUX9"/>
    <dbReference type="GeneID" id="19894407"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00709"/>
    <dbReference type="eggNOG" id="KOG1373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031763_2_1_1"/>
    <dbReference type="OMA" id="PMMRQMF"/>
    <dbReference type="OrthoDB" id="420669at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005048">
        <property type="term" value="F:signal sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070843">
        <property type="term" value="P:misfolded protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3370.10:FF:000002">
        <property type="entry name" value="Transport Sec61 subunit alpha isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006341">
        <property type="entry name" value="PRK08568.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="13">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR11112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="476" mass="52572" checksum="A25EE64B74952FA9" modified="2013-05-29" version="1">MSSGLRFLDLVKPFTSLLPEILSPEGKIPFQQRMLWTSVILLIFLVMSQVPLYGIASSDSADPLFWMRMVLASNRGTLMELGISPIVTSGMFIQLLAGSQLIDVNLDLKSDRELFQTAQKLLALVISFGQAAVFVASGTYGQPSDLGAGICLLLVIQLVAAAMIVILLDELLQKGYGLGSGISLFIATNICESIIWKIFSPATINTGRGPEFEGALLALLHLLFTWNNKTRALKEAFYRQNLPNIMNLFATVLVFAIIIYLQGFRVEIPIKSNKLRGQHGTYSVKLFYTSNIPVMLESALTSNIFIVSQMLYRKFPDNIFVKLFGTWKSVPGTSQNRAISGLAYMMTPPLNIKEALLDPIHTTIYVLFIVFICALFSKLWIEVSGSGPRDVAKQLKEQQVVIAGHREKSMYKELKRIVPTAAWLSGACIGALSIFSDLLGTLGSGTAILLCTTTIYNYFETMVKENTSNSMIDIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NV80</accession>
    <name>M7NV80_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">IST1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IST1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872533.1">
        <property type="nucleotide sequence ID" value="XM_007874342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NV80"/>
    <dbReference type="STRING" id="1069680.M7NV80"/>
    <dbReference type="GeneID" id="19894331"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00633"/>
    <dbReference type="eggNOG" id="KOG2027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037652_2_0_1"/>
    <dbReference type="OMA" id="WHPVESE"/>
    <dbReference type="OrthoDB" id="29853at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.60:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein IST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.60">
        <property type="entry name" value="Vacuolar protein sorting-associated protein Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005061">
        <property type="entry name" value="Ist1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042277">
        <property type="entry name" value="IST1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161">
        <property type="entry name" value="IST1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161:SF5">
        <property type="entry name" value="IST1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03398">
        <property type="entry name" value="Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR11036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="29757" checksum="36F2A4D3890D640F" modified="2013-05-29" version="1">MSQDVLLNKLKIQIKLCINRLRLVQQKMAAVHKQQQKELVVLLEKNKIENAMIKAENIIREDIKRELLGILELYCDVLLSRCCFLKRGHCHEQIHQAVSTLIYSMPRCEIKEFNKMNEIFRLYFGKEFIQDSIENKHNIVDPKVVEKLRYDALNNDLVENYLQKIMHLYNIGQNDKLNTFNILDSAAFCNEGFEELKKSQDSNPTSTIHSLPVSDDSESHSKSSIYLHNCNKDTSNNISNMDQLWARFERLKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NV96</accession>
    <name>M7NV96_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00802</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872708.1">
        <property type="nucleotide sequence ID" value="XM_007874517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NV96"/>
    <dbReference type="STRING" id="1069680.M7NV96"/>
    <dbReference type="GeneID" id="19894500"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00802"/>
    <dbReference type="eggNOG" id="KOG0866">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_413946_0_0_1"/>
    <dbReference type="OMA" id="SDGMGHI"/>
    <dbReference type="OrthoDB" id="185618at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13170">
        <property type="entry name" value="RanBD_NUP50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053074">
        <property type="entry name" value="NPC_Nucleoporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015007">
        <property type="entry name" value="NUP2/50/61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38697">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SIMILAR TO S. CEREVISIAE NUP2 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38697:SF1">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SIMILAR TO S. CEREVISIAE NUP2 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08911">
        <property type="entry name" value="NUP50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RanBD1" evidence="9">
        <location>
            <begin position="548"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="284"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="435"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="298"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="442"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="663" mass="74171" checksum="A335871951271CB2" modified="2013-05-29" version="1">MSKREAEKQITKNDSIFSGNTEQEVVDLAKQASKEVLLKRKIAVPQSLKKRYSEQISTHSSPFANLQEPNGKQLSTSCSTQFPTSTFSFVPPFQQEKKEKTSVESLESLSNPPSLLKNDIKNEYDLFLHRRSVNYFFQKAIDASITEDPFGDLSIACQEYIDYRKQIDKSTELSDYIQSDTKKDTAVSKEQTNKSSDDSFISPKGAFDCKNKENKNSLFSFLKKPEEKMDENIQVKMHTVDSNKLPSSTFGIHMKNDDENIQSAFGSPAAKNKSISETNFAIENTNNLSKTSQEKQENQSNTKHSLNSETKTVSTSFITNTPNTPTFSFPVVSQTNDSATNKKITSISENLSVPKISKLEKSTFSFEVKKPDIEMSNKSSNETHNKNLFSFTPITKTETNTPNNANSTPIFNFGLSVPSKDISSDFSWTPNKGIKFATSPSNNNDNNDNNNNNNNTADKTPKFQFLNPLSTGKFVNENISQHKPNESVGFEFGSKTNPGFSFGQISTFNPTFTNFEQKNVSTTETAEDDVFPQEPRTNDDLIAAKGEGEENEDTIFTTKAKIYKYFVKENRFSDLGIGILKLNIDKDTSKARVLARLEGSGKVIINIGLQKDFQYLITGKKSVKIPAVSSEGTGIDTYLVRVRDEEISKELTDLLESKKLGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVJ5</accession>
    <name>M7NVJ5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein-sorting-associated protein 46</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872209.1">
        <property type="nucleotide sequence ID" value="XM_007874018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVJ5"/>
    <dbReference type="STRING" id="1069680.M7NVJ5"/>
    <dbReference type="GeneID" id="19894034"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00336"/>
    <dbReference type="eggNOG" id="KOG3232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080826_0_0_1"/>
    <dbReference type="OMA" id="QQITMVM"/>
    <dbReference type="OrthoDB" id="10266568at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904902">
        <property type="term" value="P:ESCRT III complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="21594" checksum="7ED1E378A6F32EAC" modified="2013-05-29" version="1">MNLEQSLFQLKFMAKSLKRQSQKASRDEQAEKLNIKKAIQAGNYDVAKIYASSAIKKRAEALNLLNLSTKIDSVSRRVHTAITMKNITGNLTNIVKGMDKAINSMNLEQIAIVMDKFESQFEDLDVQSSYMENAIATSTATSAPQDEVDLLLQKVADEAGLELSQDLLNATPSNRISEQEMNDTLYERLSKICG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVX9</accession>
    <name>M7NVX9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_00482</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872368.1">
        <property type="nucleotide sequence ID" value="XM_007874177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVX9"/>
    <dbReference type="STRING" id="1069680.M7NVX9"/>
    <dbReference type="GeneID" id="19894180"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00482"/>
    <dbReference type="eggNOG" id="KOG1613">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038194_3_1_1"/>
    <dbReference type="OMA" id="EIKAFWV"/>
    <dbReference type="OrthoDB" id="45882at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11369">
        <property type="entry name" value="RNase_PH_RRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000017">
        <property type="entry name" value="Exosome complex component Rrp42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033196">
        <property type="entry name" value="Rrp43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF9">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="10">
        <location>
            <begin position="40"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="11">
        <location>
            <begin position="203"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR11467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="277" mass="31390" checksum="1670647A359192AC" modified="2013-05-29" version="1">MAENTQLSFPPEVYKKINYRQYFKHFLSSSLRPDGRSFFQFRSTSINTGSLTNTNGSSIARMGDTIFVCGIQAEIAKPSIKHPIEGWIVPHIILSPICSEKYRSGHNHVAQAISQKIVSLIQASNMLPLSSLLISKNKAVWILYADLICLNYDGNAMDVAWIALMSALETTKLPIAKWNEDTERVICEKKYKNLELNQRLFSMSFGVFDGKYILSDLCDDEENLIPETINIVIGNNRQLFNINKTGGTSMTQEMILSCIELAKKRYDELYDLINESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWD4</accession>
    <name>M7NWD4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_00048</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871902.1">
        <property type="nucleotide sequence ID" value="XM_007873711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWD4"/>
    <dbReference type="STRING" id="1069680.M7NWD4"/>
    <dbReference type="GeneID" id="19893746"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00048"/>
    <dbReference type="eggNOG" id="KOG3479">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141397_3_0_1"/>
    <dbReference type="OMA" id="QDFLRMY"/>
    <dbReference type="OrthoDB" id="1551503at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042719">
        <property type="term" value="C:mitochondrial intermembrane space chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140318">
        <property type="term" value="F:protein transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050673">
        <property type="entry name" value="Mito_inner_translocase_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13172">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="13">
        <location>
            <begin position="15"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR11607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="86" mass="9896" checksum="7E98563D960B9347" modified="2013-05-29" version="1">MESLNQKEQATLQGILEAKQMKDFMKMYSNLVNKCFSDCINEFVSKSLNSKEETCVIRCANKFLKHSERVGQRFTEINVQQASKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWE3</accession>
    <name>M7NWE3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00481</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872367.1">
        <property type="nucleotide sequence ID" value="XM_007874176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWE3"/>
    <dbReference type="STRING" id="1069680.M7NWE3"/>
    <dbReference type="GeneID" id="19894179"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00481"/>
    <dbReference type="eggNOG" id="KOG0979">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004969_2_0_1"/>
    <dbReference type="OMA" id="RFWTSQP"/>
    <dbReference type="OrthoDB" id="10254973at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="5">
        <location>
            <begin position="25"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="650"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="811"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="874"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR11466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1027" mass="120263" checksum="66486BB7CC7F8D4C" modified="2013-05-29" version="1">MVKRQKIQCMNTSDQSGFLKGSIVRLRLENFVTYDLIEFYPGPNLNMIIGPNGSGKSTFVCAICMGLGWNTSFLGRAKDVNEYIKFGSEMAHIEIELKGSDDEPNTIVSRVIHIDNTSTWELNGVSSSLKYVREKMNELNIQVDNLCHFLPQDKVCEFAQLTPEKLLRETERAVGDTEMLLQHEKLISLRASQKNDLSAKIMDQSQLENLNERQAIARRDVERFHEREVILKTIEILKFKIPFVQYSQARKAFYDFKGLRNEKKTELDKILKEYDPFFRKKTQIEATVNQYVAENNEIRNSLNYQKSALDSLILSFEEYDNSIKEICSEIRAEKRKEKERDQKIKELKETIAYMESRISDKPSENYMDDILDKLNEVNGHLKMVRKELQDLNIIIGEHMNRVKESKVALKQVQNKLDDLDNVREQRLQWLKQNDRDVFDAVIWLSNNRNKFKDHVYEPVYLEISVRDLKYADFLEACFQKNTYMAFTFLNRDDYLLFNRILVDSKEGCGRELRLHTAEFSNTSSPSLDMQKQPYISSELKQNFGMDGYLLDFLDGPSPVLNTLCHIANIHRIPVSINEISDECYRKLSRCVNSVNQLIFPVFISGKTHYTMRKSKYGRKDVSTVTKLVTKAQRFKTTVNAETKKILQQQIIDLELVIKKDEDSIQELRKTEESIKIRFNDEINRKNNLLKKKEDMEKEIKEWDRQVIRLEKTKETLYSLESFPNQYADNIKKLKEKMDEIVGQHSVSAIKLKDLILDAFQTTKDMVCASIREIQANANYVDVLEKNSEIVTKIDDIKKSYEELKQTTQNLKIIAADKLEIAQKNLEKVDEETRKEIENQMEQDMTEESLNEQINFEKMKLEFIYQTNPNVISQFEKREHDIKLLNERIKEYESRLQKVESDINDLRRIWEPRLDNIISKINCSFSEAFEYIGCVGEVRIGKSDEFDKWRIEILVKFRDNENLQLLTAQRQSGGERSVSTIFYLIAMQSISKVPFRVVDEINQGMDQKNERLVHAKLVDAMSKKNTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWX2</accession>
    <name>M7NWX2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VPS10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00099</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871956.1">
        <property type="nucleotide sequence ID" value="XM_007873765.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NWX2"/>
    <dbReference type="GeneID" id="19893797"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00099"/>
    <dbReference type="eggNOG" id="KOG3511">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000700_0_0_1"/>
    <dbReference type="OMA" id="ATMSEFI"/>
    <dbReference type="OrthoDB" id="443634at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.270:FF:000005">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF27">
        <property type="entry name" value="SORTILIN-RELATED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1359"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="8">
        <location>
            <begin position="54"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="8">
        <location>
            <begin position="720"/>
            <end position="1347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1468" mass="169957" checksum="244ACAE5BCAC1321" modified="2013-05-29" version="1">MAHLNSLNISKIFCIFSFLFFGVLGAKNYHITVTSFKHSLFSFFYFDNSKVILAHDILDKVIWKSDNEGTSWTKIKSIPKNKAKMLILHPFSDRMAFVLGEDKTHYYTDDQGLTWKSFSTENPFSEETAPLKFNSANPNYIIFIGSECVDSARINCKFMAYYTKDAFNTNPKLLKENIQSCMFAKSSKEFSNCSDELVLCVYMQSNIYASGIYLMKSEDWFSTYTHINFDEKPLVSLEGIGTVQTFIIAVVRSHNTELEMYVSKDGNTWNKAKFPYYHQKKLKENSYTIMESKPYSLQVDILTSEYPFYGGISFKSDISGIYYTPSLEHTNRNDMGYVDFEDIRFIDGAIFANVIENWKELENNGDFDKKIQSKISYDNGNTWNSIKPPINSDCNIFDSKICSLHLHSITDRYRFDKTFSSYAPGILIGIGSVGSYLKPFHECNLYISEDAGKTWSLSLEGTHIYECSDHANIIAAIPDQKTRNFYYSFDRGRNWQSIDLKHNIRPLALIVIPNSKTGKFLLIATEFNENDIDHSINAISIDIGEAFTKQCILDKNDLEKSDLEKWYSHTENESNCSMGRKQYFWRRKIGRKCFIKENYSELQVIEENCPCSNNDYECDYNFMEYDNKCLEQVPQEIPPDACKKPDDVFWAPSGYRKIPGNICDSKRGVIKDKKIEVSCKTNTHLDKIRITLTDFKGELVNYYYLKKNEDDSNDKNDADETILVLTNQMELHVSHDQGNQWNQILADENILFMYQNVYTSEQVYFFGMNKKAWVTKNRCLTIEKIQLPIYSHIEYKPEFHPDNKDWIIYTGCKDNKIMQECETESYYSLDGGNSWNLLISNTRSCSWIKTKDFDADKNLIYCEVYIFDSEKSSDNPVKLVYSTDFFNTYNVLFDSITNYARFKEFIILGKYNSQLKTLEPYISLDGLNFTIANFPSHYSGQIYTILDSSTKSIFVHVTKDDYKSFKWGSILKSNSNGTNFVKSLDFVDRNSDGFIDFERFKGLEGIIISNIVINPDDIVKGSSKRVKSLITYNDGSEWSYLTPPKEDSKGNKYCTGKLEKCSLNLHGVIERIDLHGTFSSITIPGLDFAIGNVGEYLDNYLNSNTFMTLDGGVTWKEIQKGPYLWKFGDQGSIILLVRDKDYTDHFLYSLDMGSTWKTVYFPEKESILIYDITTVYSDTSRKFLLFSIRSNNGNKWTAIHIDFTMLTDRKCKLNEDSLDKSDFNTWSFKYPNSENSCLFGTIKTYYRKKSERHCFIGKSNIKHYISKNCTCQPQDYECDYNYERASDGSCQLIQGLKPLDHLEECKKHNLLEYNKPTGYRRIPLTTCQGGKELDKDSTPIPCPSKEKKFIKLGKGLHGFELFCIIISPFIIIIFGSYCMWILYKDRFLGQIRLGEDERPSGLIQYPIILLDKITVLFSAIRTITNYIITRIISLFSGYRFNTRNSFFRNNYSALLSDSPELLYDDFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWZ1</accession>
    <name>M7NWZ1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00223</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872092.1">
        <property type="nucleotide sequence ID" value="XM_007873901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWZ1"/>
    <dbReference type="STRING" id="1069680.M7NWZ1"/>
    <dbReference type="GeneID" id="19893921"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00223"/>
    <dbReference type="eggNOG" id="KOG2628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1415708_0_0_1"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR11797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="192" mass="22051" checksum="3A24C655A8A5BB11" modified="2013-05-29" version="1">MANDHEHKVVLNEDHKPKEDFIEAKIAIRALILGIIIGSTSIASFHVNFSELTIYFTILSFFHFLEFWITALYNPLNVSISSFLFSNGNQYILAHCFSILEYLLEYLFFPQMKMHKLINYTGLSGNLQFSKKYNDFKGFAIACGGQLCRSLSMIHATHNFSHKISLKKSDDHFLVTDDGFVIHPILDFFIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3D7</accession>
    <name>M7P3D7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="13">Aconitase</shortName>
            <ecNumber evidence="13">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PNEG_03175</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875238.1">
        <property type="nucleotide sequence ID" value="XM_007877047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P3D7"/>
    <dbReference type="STRING" id="1069680.M7P3D7"/>
    <dbReference type="GeneID" id="19896862"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03175"/>
    <dbReference type="eggNOG" id="KOG0453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006714_2_2_1"/>
    <dbReference type="OMA" id="KKQGMLG"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01584">
        <property type="entry name" value="AcnA_Mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF3">
        <property type="entry name" value="ACONITATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="14">
        <location>
            <begin position="56"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="15">
        <location>
            <begin position="571"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMR08335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="770" mass="84927" checksum="7408C83055BCD366" modified="2013-05-29" version="1">MSRMVFQARRLAFASSSLQKVRISNWEKDKYIDYHHLQRNIEIVKKRLGRPLSYAEKVVYGHLDDPYTQDIERGRSYLRLRPDRVACQDATAQMTILQFMSSGISDVAVPTTVHCDHLIEAQIDGKKDLIRAYNTNKEVYDFLSSACAKYNIGFWKPGSGIIHQIILENYAFPGGLMIGTDSHTPNAGGLGMVAIGVGGADAVDVMIDIPWELKCPKIFGVKLTGKLGGWTSPKDVILKVAGIFTVKGGTGAIIEYFGPGVESLSCTGMGTICNMGAEIGATTSLFPYNRRMREYLVATRRSYLADHLDNYSHILSADEGCEYDKIVEINLSELEPHINGPFTPDLSTPISKFKEAIKLNNWPSELKVGLIGSCTNSSYEDMSRSASIAKDAYDHGLTVKSKFTITPGSEQIRATIVRDGYLKILEDVGGVVLANACGPCIGQWDRRDVKKGERNSIITSYNRNFAGRNDANSSTHAFISSPDIVTAMVFAGDLSFNPITDTLMGADGKEFKLSPPNGEGLPSKGYDLGENMYQAPPEDRSSISVNIDPSSERLQLLEPFEKWDGKDPLNMPILIKCKGKTTTDHISMAGPWLKYRGHLDNISNNMYIGAVNAENGELNKVKNQLSGKYEKVPDVARAYKAKGIKWVVIGDSNLGEGSSREHAALEPRHLGGCAIIAKSFARIHETNLKKQGMLPLTFACESDYDRISSDDRLDIIGLTEFAEGKDLILRVHPKNGEVWEAVLNSTFNKQQIEWFKAGSALNYMASLKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3H0</accession>
    <name>M7P3H0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_03220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875283.1">
        <property type="nucleotide sequence ID" value="XM_007877092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P3H0"/>
    <dbReference type="STRING" id="1069680.M7P3H0"/>
    <dbReference type="GeneID" id="19896907"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03220"/>
    <dbReference type="HOGENOM" id="CLU_733874_0_0_1"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="377" mass="42801" checksum="9998AEE2A0D1D863" modified="2013-05-29" version="1">MNEIQSNTSGVYNGLLQETLQNVSTPHKEYNFFMDHELSIPHTLFLKENHTPVSYPLTLDNNSDLVSPSLKLAKSASLHEIQLPSNFDHNKSYFSSYEPYVNSVSTKFDCPDISSLSLSGQSTIYSPLQDRNTTFSPLLNNSKSIFSDDSFSLKSERSLKAENYSTQSIFTKKYPENNNLHDTSFNFSVKDNWSGPWKNSTTLQSNSKTSPKSLFNDKLRLPVSQKSYTFNESQSQKTDEHETTSNINFLSNPSSFGTSPSSRFCTFFSKYNDYSDNLTLKCSPGSVLYHDHIQPYHNDYNYCQTNELQIPSVLLNSAKNNVFHSKDISIIPEQKSLENLNKNSSLLSTNDIIKRSVATIDDEIQFDMDEEISQNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3K0</accession>
    <name>M7P3K0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_03256</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875323.1">
        <property type="nucleotide sequence ID" value="XM_007877132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P3K0"/>
    <dbReference type="STRING" id="1069680.M7P3K0"/>
    <dbReference type="GeneID" id="19896943"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03256"/>
    <dbReference type="eggNOG" id="KOG0541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072440_3_0_1"/>
    <dbReference type="OMA" id="TEWGKAH"/>
    <dbReference type="OrthoDB" id="1882547at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF39">
        <property type="entry name" value="PEROXISOMAL MEMBRANE ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="27"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="6">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="183" mass="20573" checksum="722B3B5E6A813EC5" modified="2013-05-29" version="1">MRSSLSFIRRIHINRIYGFRCENMVEIGPGDRIPKEKLMEKDLSDLVDLSDILPKKAIIIGVPGAFSPTCSMTHLPGFFSKINKFEEKGVGLMACISVNDVFVMNAWKSSFSIKSPLVRFFADPSAQWTKAANLSFDATKIFGNYRSKRYVLFLEDGLVKKAFIEPNFVGLVESTAEKVLHSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3M6</accession>
    <name>M7P3M6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Condensin complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_03280</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CND1 (condensin subunit 1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875353.1">
        <property type="nucleotide sequence ID" value="XM_007877162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P3M6"/>
    <dbReference type="STRING" id="1069680.M7P3M6"/>
    <dbReference type="GeneID" id="19896967"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03280"/>
    <dbReference type="eggNOG" id="KOG0414">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001867_1_0_1"/>
    <dbReference type="OMA" id="CPLEKLW"/>
    <dbReference type="OrthoDB" id="436262at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140602">
        <property type="term" value="C:nucleolar peripheral inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000272">
        <property type="entry name" value="Condensin complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032682">
        <property type="entry name" value="Cnd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007673">
        <property type="entry name" value="Condensin_cplx_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024324">
        <property type="entry name" value="Condensin_cplx_su1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12717">
        <property type="entry name" value="Cnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12922">
        <property type="entry name" value="Cnd1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017127">
        <property type="entry name" value="Condensin_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="6 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensin complex subunit 1 N-terminal" evidence="12">
        <location>
            <begin position="73"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Condensin complex subunit 1 C-terminal" evidence="11">
        <location>
            <begin position="974"/>
            <end position="1134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR08450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1171" mass="134204" checksum="89F0C8043838207B" modified="2013-05-29" version="1">MIFDLKEFLTAYLDDPENFLLDDNIEDVSKDVNCAIDNIIDAISTSLGIILEEEFMKSLFAILRTFEHIPSGSSNKFVDLIISSLQQVTESLLRDILENEIDIQDQRKNILEILGFSLYWLVSIIERITSNVSHSQNFFRGTKSFKLNKKTQKEENLDINYFFHNSLDVMCKILGLRLSKLWVTTSERDIFVSLFIRSAYLIFENEQLMKIPSVKMRVFKLLCIAVKHQGHAFGAQTSLIQGLQYYEHLPELVAEFLQILSEQYDYPQLLDEILRELSVKEFNSNDNKGPKSISLFLVKLSDMMPRNVLKQMTMIIKFFDSDSYTLRCGIIEVCGNLISSLFQSEQSNDHKGQIDRFFDILEERFLDVNPYCRSKVIQVYLKLCDLNNKFPKRRQIVTDLCVRSLQDKSSNVRKNAIRLLSKLISTHPFSLMHGGQLFKKLWCERLEAIEKQLNLLKPPVESPGLSKKKSLNHDKILEDFEYANLDDEKIIYKDPFSGISLENAKDNSDSNISFDNFMKLHFTKRYYCEALKFIESIHMGSVLVNQLLASKNKSEVLEAMEFYVVADAYKLEIAKSGIRKMLHLIWTKSTSDEGKAVQAKLIECYKGLFFDPPDGLNANEIANYIARNLISLTYGATLAELTSLEQLLCVMMREGYISDNVIKKLWGIYGTQKENVSKQQRRGAIIVLGMLGLADSDIIASGLECLLHVGFGDYGKNDFFLARYSCIALQRLKQVNGNSKDSSDYFQARLVDDHIIFSKLGNIILLPTENIEWFSVAEQAINAIYLLAKYPDKICTNLLRSKCKSVFRSFSVKKIGLDDDSLSIKSSSLLSQLLFIVGHVALKQIVYIESCENEFKRKKSDNQKVGNFQSHSLKISSATNSNELDFVVGTVEDDFSEAMNYIREYELLYGNNSLLARFCPLVQEICTNNHLYKDSCLQSTAALTLAKMMCVSARFCELNLPLLFNILEKSSDPLIRSNLVIALGDMNVCFNHLINENTEFLYRRLKDDDSSVKKICLMTLTFLILAGQVKVKGQLGKMARCLEDDDRRIVDFAKMFFTELSIKDNSIYNNFPDIFSSLSNDSESLDEASFKRIIRFLISFIEKEKHAKQLAEKLVIRLSKCDTERKWNDTAFAISLLPHKNDMIHKIVTDGYCHDIGIKQPIEHFKNDMIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3W6</accession>
    <name>M7P3W6_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_03036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875087.1">
        <property type="nucleotide sequence ID" value="XM_007876896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P3W6"/>
    <dbReference type="GeneID" id="19896723"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03036"/>
    <dbReference type="HOGENOM" id="CLU_2027716_0_0_1"/>
    <dbReference type="OrthoDB" id="10347881at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032157">
        <property type="entry name" value="PAC4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16093">
        <property type="entry name" value="PAC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="122" mass="13840" checksum="17EF74B20A986627" modified="2013-05-29" version="1">MSSLSLISTKERTIRLHPSLPPILIRLILLRPSTSLIFILNFLEKPLFGSLSLSIWTKDKGASSTSLRTTNIHSISQQLSCLLAKRFARQCYVATPLEAEWTVEYMECILNTCIELVKEEQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M7P4U0</accession>
    <name>M7P4U0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874651.1">
        <property type="nucleotide sequence ID" value="XM_007876460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P4U0"/>
    <dbReference type="GeneID" id="19896323"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02632"/>
    <dbReference type="HOGENOM" id="CLU_1355148_0_0_1"/>
    <dbReference type="OrthoDB" id="5386765at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="202" mass="23642" checksum="F5A665AFB8433196" modified="2013-05-29" version="1">MVLHNDKWKKKASKKYHNKRGTALGSDLNESSARKINISSEDNHHNSDELLSNRKVNNYVETIISDEDIWVDYTKVLAKEFTLPEPDIISNDELPKNRFGKGKLVYEDAENVYHLRRQVENELSLKEIKKKYNSRVKVRTVKGLCLDMEKSESDIEDIDELLKKTEFVEKQIDDNISQEKSIQMNTIIKDKELEDFLDKLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7P613</accession>
    <name>M7P613_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major surface glycoprotein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_03599</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874624.1">
        <property type="nucleotide sequence ID" value="XM_007876433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P613"/>
    <dbReference type="STRING" id="1069680.M7P613"/>
    <dbReference type="GeneID" id="19897286"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03599"/>
    <dbReference type="eggNOG" id="KOG3544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010455_0_0_1"/>
    <dbReference type="OrthoDB" id="5489296at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021041">
        <property type="entry name" value="Maj_surf_glycoprot_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003330">
        <property type="entry name" value="MSG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF421">
        <property type="entry name" value="CUTICLE COLLAGEN DPY-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02349">
        <property type="entry name" value="MSG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12373">
        <property type="entry name" value="Msg2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082719" description="Major surface glycoprotein 2 C-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="domain" description="Major surface glycoprotein 2 C-terminal" evidence="4">
        <location>
            <begin position="1004"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="894"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1172"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="150"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="915"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="937"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="960"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="978"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1181"/>
            <end position="1201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1224" mass="137924" checksum="3B9DB10A9F64C2C1" modified="2013-05-29" version="1">MRSTSFTFLVYLGCILVAALENAISNINKQELQVIELFENEKLLGSEKIRGSKGIWNPRINKDSYMDYFENHPGVDYFRKDDYENFFPEGYPQDNQWVEEITQKRAVTAQLVKRQAPGQAAGNDEIKEEQVLGLIVKNEYKNDDNCKKKLKEYCEELEKIDGKLENVDSKVKGLCNDKEKKCQDLKQKIQNELNNFKTELENALKNLTDEKCRKCEEKCVLLEEADPTNLKDNCVKLRDRCYKQRRHGVAKEILLRALNGKVTDINECEGKIKGVCQELSGYSDELMFSCFNAYTTCEYLGGNHTDNCKPLETELKDNELMEKCQEYLKKCYFYGSSCKNAKCDNIEKKCEEKGIRYRSPKLDFSPILHKPKLMERIEMENLYKEEEAKGIIIGRPKEKSFETVLLLLSEGKNNKLEEKCKNVIGNCEAFKYLDIMLENSCREASKKKEEKCKEIPNVKKKCLNFKIKLYTKGMSTEFEENKDSGLFSWRELQKSLSREDCIELESECFYLENVCTNKIENACKNVRATCYKKGQDRALGKYFESGLKNLRYLNFTGKKSECQKLVRDKCKKVNGDRKYMKKCLHPEELCLELLDDISVQSKELGETLDNVRDLPGKKDCVELKKRCDYLRNNSRLSDKKCATLDRQCRYLGVMEEMRKRFLKRKDDSLKTSKNCIDALKEECKGLSKEEKNPFSILCALPEETCEFMIAKTNIECFTFKDRTENILKNNNKNKNLVKRLCLSWSLYSDEYMEICSKILEEKTNGKESLQELKKNCDPFWKELELEKDLMHELKGNLGKDDECKEALKKHCTEQKNQTNQKFNSFCNTDKDNGVEEKVCKKLVEEVKRKCPTLKNELVKEKDELKEKKDEYEKVKQESEKFAKEAKLLLSRLEQDGQGGGSKVQDNSAPKPVDPAAPVAPVAPVAPVAPGTPGGTPGAPSTPGTPGAPSTPGAPGAPSTPSTPPAPAGPAGPSGGTPAGPPAGPPAGPPAPGGSTPSGTTNTSNVILVRRTFVSGEVSEAEKKAFVATARALELYLGLKEKCKTLKGDCGYRKDCPDCDTVCKEIDKLCEEIEGLKIISHPTATLTTIQATTKTATTTTTTTMTTTATTTATATETTATTTTESIDGEKVTEQCTLVRTTDTWVTSTSLHTSTMTSTSTVTSTVTLTSMRKCKPTRCTSDSSKETETQKEEKEEEEVKSNEGMKMRVPEIVKIILLGVMVIGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M7P620</accession>
    <name>M7P620_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription regulator Rua1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02247</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874234.1">
        <property type="nucleotide sequence ID" value="XM_007876043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P620"/>
    <dbReference type="STRING" id="1069680.M7P620"/>
    <dbReference type="GeneID" id="19895940"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02247"/>
    <dbReference type="HOGENOM" id="CLU_347846_0_0_1"/>
    <dbReference type="OrthoDB" id="5595379at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028012">
        <property type="entry name" value="Rua1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28125">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28125:SF2">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14616">
        <property type="entry name" value="Rua1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator Rua1 C-terminal" evidence="2">
        <location>
            <begin position="596"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="755"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="767"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="811" mass="94248" checksum="12A6FD3B1EC61026" modified="2013-05-29" version="1" fragment="single">MMEAFVSDLYEIREKENQWFSSSLNSEEPGFIYNELSSHEHGHSAIPFAYSSPLNDQYMFPSIQNINNIVDYGLENHKNSFGIYRNSNGYKKYASNEINLEYNQKSLLNTIEKTENDFLDSSFYEVENALLLNEKKLNTFISSDNKQLVPTEKHINDLDVFNGTTNINNPDDNFISIWEDTQNLMLSSQILSNTDDEPQQTSKYLSTININSNIYNQPQNQTLDISSMINTNVKDNAFSPRCFSDLRINSEYAFDSDMMLKSSDFQATSKQFQKNFCNRLANHYNLENIWKPLFMEPNTICPASLSSPTFSYQYTKDNNSSNSSETQNCLWKISSENLTSTPSTLISTSIPLISQNINQDNPTLTSFIRSYNTLKTQYSMKQVHSILTIHRVIFKLNHYARGLDWKHFLTACLQPLSNYTPPIVLPWKPAYVHCLKGYEECWNWEWAPKNRDSKPKEENNQKNKLLFLPPNLPFGSKDVPLFLNSKKRINPSMLTKALENCPQEFKELITYKEEDFVMQCPAIYLRLSTEMKAPNLAPQLRNKGLKPIPADDRFYYRSSLFDPIVPLDHYTISSELLVHSDPNERPYQNTKFEFIDRYNPEYYRYKGSKKQAHCSLCPPGGYDTGDDSKNDIFSVGNWYVTKCSAFWYHKRYKHGIRKYGYPYPYPENIEVIKDKSVQAQCPICHKWMKAGMVDDTVPRAFWTHYDQCWNMVEAILSPKKRKKDDEPCESNNIYGIRSKYTSYSNGLEKSTVKSKSELKVQGKEKDDDIEDEEMDEPVVLPTILPPLEIDDGDEYFPEEDEFSFVILKKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6N5</accession>
    <name>M7P6N5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874112.1">
        <property type="nucleotide sequence ID" value="XM_007875921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P6N5"/>
    <dbReference type="STRING" id="1069680.M7P6N5"/>
    <dbReference type="GeneID" id="19895823"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02130"/>
    <dbReference type="eggNOG" id="KOG0381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1086325_0_0_1"/>
    <dbReference type="OMA" id="WIAFIKE"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09011">
        <property type="entry name" value="HMG_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="84"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="182"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="84"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="182"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR09545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="256" mass="30256" checksum="4B6130ADD731D3AC" modified="2013-05-29" version="1">MISTNFIISIGFSTKTLGYRGIRAVFKRCLGGMIPINKEYIIQWTNTRRNKKNLFYDFHRFNSSKSTSRSTKANQELKALPTPSRMGYSPWIAFIKEKFKQMTGNGKEIMKQCSSIWKNMSQEERQTYKDISSESRLQASRTYMNWINSLSPKEIMKENHIRNQLRKQGKKGITFIKDPRKPKRPLSAFLFFCAYARSSPDFIEKYTEGTTKITEQTKILAKKWALMDDFEKQEFINSSINDKERYQKELEIYYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7P7V5</accession>
    <name>M7P7V5_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873672.1">
        <property type="nucleotide sequence ID" value="XM_007875481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P7V5"/>
    <dbReference type="STRING" id="1069680.M7P7V5"/>
    <dbReference type="GeneID" id="19895402"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01708"/>
    <dbReference type="eggNOG" id="ENOG502SAJQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_352367_0_0_1"/>
    <dbReference type="OMA" id="MIDACIC"/>
    <dbReference type="OrthoDB" id="2148418at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="798" mass="91533" checksum="4DA0F0A6421530E0" modified="2013-05-29" version="1">MDVQKERIDEEKSKKRDENETILDLSDGVVYFGTPTSAEKRLHAMETPPKHVSSRRKTVLLPSKAILYSTGNLNQQENYKERKSRRQSYLYATKNSVMLEQQRLQEIMDDKDFALYSNNSMDENLLFTEAPGSVERKIRKKSDTGKLSLTPSTCQKRVKTSRQFSVFNTMIPRSISTISRRKSTSLLSQKQNKTLHHAFEKDIWMSEMPLLCCIRIQATIRGYLIRKSIFLQNQAAKIIQHKYITILAKRKFFHQKRSAIIIQSAWRGWLGRMRYLEMIDACICIQKWWRQLFKEKKAKQTKAVVRVEEKEVMKNISNNSSLQGFLRKWESKKALVTAAKDKNLKRNSLLENNTSMVDNIKENIPFRLVEELSPQKPNPPISNESPKSFKKTEKQRILSSYSRSVSSMTLMLKQSISTTRILSDPTNSILSTTAHNYPVSFQNRPKLPRSQLAAPGFTSRTSVLTDISPNLLKQDTINVLNTPAKKNKVDGTSMVTLKVSTPSPKKNPCLVSPLRKTIKKNQPLGYRRTALLAPQNINSMHFSYIIPESTSPQKNVSHFVNNGLGSPSRHKIINQSDLASKNLEVSNEERNLLTRSRTIELKTLSTSTLQTYTSAIKNTISQNLSNSYRPLNYLTLGEITKMTRQNTYQNRIYRCDFNRVIVRKNYLRPPSPTAKSQSKLAAEARIRRKKFQKEKMHDYALGPGDDDNWIPRELTPLKKGVKWNKLLESEIGEPNHTLEKLNSGKVKVQKGCLSKKTNLIRLDDLGNVLDAHEPLTPIIGKAETVIIQKFLYKGEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7P8Y1</accession>
    <name>M7P8Y1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_01543</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the GSE complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873490.1">
        <property type="nucleotide sequence ID" value="XM_007875299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P8Y1"/>
    <dbReference type="STRING" id="1069680.M7P8Y1"/>
    <dbReference type="GeneID" id="19895238"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01543"/>
    <dbReference type="eggNOG" id="KOG3886">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044099_1_0_1"/>
    <dbReference type="OMA" id="LIPNMQD"/>
    <dbReference type="OrthoDB" id="10020193at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11384">
        <property type="entry name" value="RagA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.190:FF:000002">
        <property type="entry name" value="Ras-related GTP-binding protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000276">
        <property type="entry name" value="Ras-related GTP-binding protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039397">
        <property type="entry name" value="RagA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF1">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-0458">Lysosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR10280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="311" mass="35971" checksum="125AD504D7680402" modified="2013-05-29" version="1">MKKKVLLMGKSGSGKSSMRSIIFSNYIAKDTRRLGATIDVEHSHVHFLGNLVLNLWDCGGQDAFMENYLSAQRDHIFRNVEVLIYVFDVESREFDVDLHTYESCLEAIRENSPKAQVFCLIHKMDLVQEEMRDYVYQERSKILYQRSENLETVILATSIWDETLYKAWSCIVYTLVPNIPTLEKHLKQFALHVEADEVVLFERTTFLVISHTSRPEFNHPDLHRFEKISNIVKQFKLSCSKMQSQFILFELRTCPFSAFIAPYACDTYILVILSDPLVQSAALLMNIEIAKNSFERIDVPDKNHVKTVSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7P933</accession>
    <name>M7P933_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01598</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MUB1/samB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873555.1">
        <property type="nucleotide sequence ID" value="XM_007875364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P933"/>
    <dbReference type="STRING" id="1069680.M7P933"/>
    <dbReference type="GeneID" id="19895293"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01598"/>
    <dbReference type="eggNOG" id="ENOG502QTM3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014851_2_0_1"/>
    <dbReference type="OMA" id="QDMQYWA"/>
    <dbReference type="OrthoDB" id="5594178at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990304">
        <property type="term" value="C:MUB1-RAD6-UBR2 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900735">
        <property type="term" value="P:positive regulation of flocculation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051664">
        <property type="entry name" value="MYND-type_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442:SF1">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="8">
        <location>
            <begin position="433"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="480" mass="56131" checksum="AD4F3BA9DD4184BA" modified="2013-05-29" version="1">MRESNFCSPSQNKASIGITSALYDRRALDCTAVLPLVNSLSHLSFLTSTSSRIREILTEDEGLERLVRILKEGCRKNRLDMWKWQLAFQCVVNVGIRGSERVRTRVVEAEMVPVIVTILEGFLERLERDQEIQSGGEIRRMRYPFLTQMIGYSITEPMTEQIGRIGWRRWEMTEDNRGVERDNRRFERGTIESSRNLSTEETLSVLQLEESVRDTISSFSSMNEFVRGPFLSQTYQIGNSIESDDGNSDDVSSRERIRLNEGIQRDVFETAIEHIEESEQTGDAMEEDNALISDVYPIHLTEQMPENGMQLSNERSSELTMQESVQQPLFFDSRHFFFRNEDNVVFCLQLLAYISKYPQLRSYFQNSHDIPRLRYGNTGEIDEEKVTPINVFALVERFTLRIHPIEVQYWAGVIMRNACRKDESRGGIRQCAYIDCGRWETFNRQFAKCRRCRRTKYCSKQCQSRAWPGHRWWCRERASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7P972</accession>
    <name>M7P972_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptide transporter PTR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873025.1">
        <property type="nucleotide sequence ID" value="XM_007874834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P972"/>
    <dbReference type="STRING" id="1069680.M7P972"/>
    <dbReference type="GeneID" id="19894807"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01110"/>
    <dbReference type="eggNOG" id="KOG1237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004790_4_2_1"/>
    <dbReference type="OMA" id="QYFFIGC"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01022">
        <property type="entry name" value="PTR2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="63019" checksum="636ED033B6047C3B" modified="2013-05-29" version="1">MIEEVQKEIIQEKISDQSSLVEPTEEELLTLHRVSGKIPLSAYLVVAIELCERFSFYGLTTPFQNYIQYKPTDVIPGALGLKQSGATALNSFFSLWCYLTPILGAIIADQYLGRYSTIFWFSWVFLAGQIILIFTSTPAAINSGASLWGLILSMIIIGLGTGGIKVNVSPLVVEQYKSRNLYVKTLKNNKRVIVDYNVTLQHIFLVFYMAINIGSFGGILTIFLEKHVGFWLAFLVPACVFSIGMLVLIIGRRLYICQNPQSSVVLNAFKAIYIAIRSGFKLDNAKPSKTNGKHKLYWDDTFIDELRVTLVACRIFLFFPVYWLLYQQIVSNLLSQAGTMELNGLPSELAQQINPLVLVTMIPLFNNFIYPKLRKYGILFRPITRISFGFFVGSLAMAYSAIVQQMIYNSPPCYKYPGDVTRCSAIKRRGEPNKIHVAYQLPAFALVGISEIFSSITGLEYAYTKAPSTMKSFVMSLFFLTVAAGSIIQMALTPAFKDPLMVWFYSSVSIGSFITGTVFWFLFKKYNSLEDEMNSFQRSIRDIKNKDFKDAENKPVEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M7P983</accession>
    <name>M7P983_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01125</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane magnesium transporter (TC 1.A.67) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873040.1">
        <property type="nucleotide sequence ID" value="XM_007874849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P983"/>
    <dbReference type="STRING" id="1069680.M7P983"/>
    <dbReference type="GeneID" id="19894822"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01125"/>
    <dbReference type="eggNOG" id="ENOG502R2CA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132206_0_1_1"/>
    <dbReference type="OrthoDB" id="44756at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053279">
        <property type="entry name" value="EMC_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018937">
        <property type="entry name" value="MMgT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28144">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28144:SF1">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10270">
        <property type="entry name" value="MMgT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="98" mass="11461" checksum="EF3E3C0BEB6F8333" modified="2013-05-29" version="1">MLFHGGYSVHEIVSLMKSIDQEVKIPIDVILEVILSLIIFCIERVFFAEKLQPISYSKYINAKKESGDLIHSILDHRPGFIDIRQKRRKYKSLKEKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7P9Q5</accession>
    <name>M7P9Q5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873234.1">
        <property type="nucleotide sequence ID" value="XM_007875043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P9Q5"/>
    <dbReference type="STRING" id="1069680.M7P9Q5"/>
    <dbReference type="GeneID" id="19895005"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01308"/>
    <dbReference type="eggNOG" id="KOG1992">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009614_0_0_1"/>
    <dbReference type="OMA" id="AENEFLM"/>
    <dbReference type="OrthoDB" id="3268246at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046827">
        <property type="term" value="P:positive regulation of protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061015">
        <property type="term" value="P:snRNA import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF8">
        <property type="entry name" value="EXPORTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exportin-2 central" evidence="2">
        <location>
            <begin position="14"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-2 C-terminal" evidence="1">
        <location>
            <begin position="386"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="825" mass="95804" checksum="4AD9C6EAEBE9A416" modified="2013-05-29" version="1">MIVNLCILQTAHSIFGRWRSQFRSDSLFSEILFVLEKFCTPYKNLFQRLDELIMQNSENREALDLLFKNLILCIKIFYDLNCQDLPEFFEDNIEQWMGLLHKYLNYSNPLLVSEDHDIEGPLEKVKSNICEIVELYTQRYEDAFSMLPEFVNTSWNLLTNTSFEKKNDILVEKIMAFLTSVAKIQRYSYIFKSQDVLRHLIENIILPNISFQESDKEFFEDDSVEYVKRDLEEFDCNLRRNATSNFVRALLEQFETDVVSIVSTYINHYLVEFQKDKRKNWRAKNTAIYLFFSITIKSSANKLGVTSVTTITNVVDFFSQNIFQDLSLLSEDIHAMLKMILIKYVYIFRNQLQRDQILSCLPLLINYLNFPNYAVYTYAAVTIEAILNLNKEEGFLIEKMDIVQLSKELLDNLFKLIEKASTLGKLSENDFLMKCTMRVIATIKDGIIPLIDTISSYLINIILEISKNPSNPKFNHYVFESLAILIRYSAPNSREILLRLESSLFPSLRLILQNDVTEFIPYVFQILSQLLEYHNLSLPDIYKLLVPPILLASLWESRGNVPALVRFLKAVISQDPLFIVNSNYIEQILGIFQKLNSSRLDDHYGFELLETVFLHLPASVIEPYVKQIFLLLLTRLNQSRTGKFVECFIQLIFFLSAINKKEYGPDYFINVINNIQTGLFEQVFSMFCLPGVQNIKDTIDRKTCSIGMIIMLCRGSALQEIKYPTLWSSTLIAILKLFELPFEVTKNDEIIEVDIDDIGFQASFSRLAFSVKAKQDPCMFIKDPKAFLIEELMKGNSANRGNFSRIISTMSDDVKTVLTTYGYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAD2</accession>
    <name>M7PAD2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial import inner membrane translocase subunit TIM16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit tim16</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">Presequence translocated-associated motor subunit PAM16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_00938</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM16/PAM16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872850.1">
        <property type="nucleotide sequence ID" value="XM_007874659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PAD2"/>
    <dbReference type="STRING" id="1069680.M7PAD2"/>
    <dbReference type="GeneID" id="19894636"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00938"/>
    <dbReference type="eggNOG" id="KOG3442">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101461_0_1_1"/>
    <dbReference type="OMA" id="RMFKIND"/>
    <dbReference type="OrthoDB" id="10262892at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000006">
        <property type="entry name" value="Import inner membrane translocase subunit TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005341">
        <property type="entry name" value="Tim16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388">
        <property type="entry name" value="MITOCHONDRIA ASSOCIATED GRANULOCYTE MACROPHAGE CSF SIGNALING MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03656">
        <property type="entry name" value="Pam16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR10790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="125" mass="14010" checksum="138F11557140483D" modified="2013-05-29" version="1">MAHHLIAQIIIVGTQVLGRAFVQAYKQAALNATLRHEKKKGYMSSEEDSGFSMGNLSEKTGITANEACQILNIKKMPVELSDVIKRYEYLYKTNDPKNGGSLYLQSKIFWAKERLKGDISEGKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAJ5</accession>
    <name>M7PAJ5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01017</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872930.1">
        <property type="nucleotide sequence ID" value="XM_007874739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PAJ5"/>
    <dbReference type="STRING" id="1069680.M7PAJ5"/>
    <dbReference type="GeneID" id="19894715"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01017"/>
    <dbReference type="eggNOG" id="KOG3486">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_167122_2_0_1"/>
    <dbReference type="OMA" id="GESDACM"/>
    <dbReference type="OrthoDB" id="278325at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1230.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001931">
        <property type="entry name" value="Ribosomal_eS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018279">
        <property type="entry name" value="Ribosomal_eS21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038579">
        <property type="entry name" value="Ribosomal_eS21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10442">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01249">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002148">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00996">
        <property type="entry name" value="RIBOSOMAL_S21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR10870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="87" mass="9881" checksum="D46453C118E2A754" modified="2013-05-29" version="1">MENDQRVLVDLYVPRKCSATNRLICAKDHASVQINICSVDADGRQIPGKYTTYVLCGFVRTKGESDDCINRLATRDGLLKKVWSYQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAM0</accession>
    <name>M7PAM0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01046</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872959.1">
        <property type="nucleotide sequence ID" value="XM_007874768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PAM0"/>
    <dbReference type="STRING" id="1069680.M7PAM0"/>
    <dbReference type="GeneID" id="19894744"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01046"/>
    <dbReference type="eggNOG" id="KOG3841">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017270_0_0_1"/>
    <dbReference type="OrthoDB" id="10006572at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.40">
        <property type="entry name" value="TEA/ATTS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000818">
        <property type="entry name" value="TEA/ATTS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038096">
        <property type="entry name" value="TEA/ATTS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050937">
        <property type="entry name" value="TEC1_TEAD_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834:SF0">
        <property type="entry name" value="PROTEIN SCALLOPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01285">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00065">
        <property type="entry name" value="TEADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00426">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00554">
        <property type="entry name" value="TEA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51088">
        <property type="entry name" value="TEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TEA" evidence="7">
        <location>
            <begin position="62"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="TEA" evidence="6">
        <location>
            <begin position="62"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="560" mass="63043" checksum="3AC840A7CCA48D16" modified="2013-05-29" version="1">MSFVLGVAETVNAEKCPLGEISQNVESLGGSKIGTSRVEDVLSLKEGLNGMKRARLKYEKRENFGEKVWPVDVEEAFMDAIAHIPKLGRRKIVVGSKACGRNELIADYIYRRTGKIRTRKQVSSHIQVLKHLRREDPEFLRMISDTPCVSPEKLKPNHTFFTPSSPPLVNFDSSVPCRQSNTFDFSRSLPNNFLPSSIPKYPYFRVLEFSIWKTSFASEHVYSRLKDSSLTTVFLDSLPNWSVRFPYLVEVLLSPIGITCPVYYVSSILSIPSINDEKSAFQAHFVLSKPPTTVQDETWGCVIRIYTMSQCILELKQKAFVHDENIILPFAIDFWATFLSGLNSLSAEYHPADDSAGAEKSKYRKEWEIRVAVRGITVVFEVLRFSNSSSRMALLAWEFDTIFSDSGTTICKEVVFDRFSNNSCENEQLFTPLSNYEQCATPCMNFHSSPLSVYSTNCPIPLSNYLSPPSIMRPTNIPILYENLQQYAPSQAPNIANSLSFVSSGSYDSQDKFLTGSISENETVNAWQTESFPKLGFFSTDSNGVSTFDDSGNIKKNDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7PBV0</accession>
    <name>M7PBV0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA topoisomerase I</fullName>
            <ecNumber evidence="7">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA topoisomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_00379</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="7"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872252.1">
        <property type="nucleotide sequence ID" value="XM_007874061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PBV0"/>
    <dbReference type="STRING" id="1069680.M7PBV0"/>
    <dbReference type="GeneID" id="19894077"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00379"/>
    <dbReference type="eggNOG" id="KOG0981">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009193_1_0_1"/>
    <dbReference type="OMA" id="HRWKEVK"/>
    <dbReference type="OrthoDB" id="47179at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00659">
        <property type="entry name" value="Topo_IB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03488">
        <property type="entry name" value="Topoisomer_IB_N_htopoI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.41:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.11.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.15.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.11.10">
        <property type="entry name" value="DNA Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="entry name" value="Topoisomerase I, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.41">
        <property type="entry name" value="Yeast DNA topoisomerase - domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013034">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013030">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025834">
        <property type="entry name" value="TopoI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014727">
        <property type="entry name" value="TopoI_cat_a/b-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008336">
        <property type="entry name" value="TopoI_DNA-bd_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036202">
        <property type="entry name" value="TopoI_DNA-bd_euk_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013499">
        <property type="entry name" value="TopoI_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048045">
        <property type="entry name" value="Topoisomer_I_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051062">
        <property type="entry name" value="Topoisomerase_IB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290:SF3">
        <property type="entry name" value="DNA TOPOISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290">
        <property type="entry name" value="DNA TOPOISOMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14370">
        <property type="entry name" value="Topo_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02919">
        <property type="entry name" value="Topoisom_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00435">
        <property type="entry name" value="TOPEUc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56741">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52038">
        <property type="entry name" value="TOPO_IB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DNA topoisomerase I eukaryotic-type" evidence="10">
        <location>
            <begin position="371"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="177"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="735"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="6">
        <location>
            <position position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR11350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="847" mass="99267" checksum="1FDC6DBF99391FB8" modified="2013-05-29" version="1">MDEKVVNSRHFEGKLAENKDKYTKNKEDRVYASSLKIKNKPEKKKSKKRTKGVIESDKESNSGKEMEKCLKKKKEINKENIKTINYDLEHFKTENEDLCLEKPTFTLYKKILNNENDLNLSNLEEKNGLRKDGLVDSIKEKKTRKRMLKSKQSDNLKDKASENIEIKKEIDESYVETEKKLKKKHKTSEKELNSEKSKNEELSQSKEEEEDYKWWEQQQGDGTIKWKTLEHNGVLFPPPYEPLPSYVKMKYKGEPISLPPEAEEIAGFFGAMLSSEQYVKNPTFQKNFFHDFQETCKKTNAPVIPEKFEYCDFTPMFEYFEKKKEEKKNKSKEEKKKLKEEKDALEEKYKYCFLDGRKEKVGNFRIEPPGLFRGRGDHPKTGKLKTRVVPEQVIINIGKDSVIPSPPPGHNWKEVRHDNTVTWLATWNENVNNNVKYVFLSAGSSLKGQSDLKKYEKARELKLYIDNIRKQYREELEDKLMEVRQRATAMYLIDVFALRAGNEKGEDEADTVGCCSLRYEHISLRPPNTVVFDFLGKDSIRYYNEVQVDPQVFKNLKIFKRSPKTEGDMLFDRLNTSKLNNHLTSLMPGLSAKVFRTHNASYTMSEQLKNTPKDASVSDKVLAYNRANRMVAILCNHQRTISKAHGAQMERIEDKILALKYQKIRLRKAILTLDSQLGKNRPDLSEAISDIDEDWIKEHQKVLIEKEYDKIKRKFQKDNEKLLSQNEKPMPESHLEKFLKKINEMKEDFRIENEKGIVESKKRGITIEKLDLQIKKINERIRQMKALMIDKDQNKTTALGTSKINYIDPRLTYAWCAKYGVNIERVFTKTLREKFAWAASTTADWEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7PC56</accession>
    <name>M7PC56_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CTLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875591.1">
        <property type="nucleotide sequence ID" value="XM_007877400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PC56"/>
    <dbReference type="STRING" id="1069680.M7PC56"/>
    <dbReference type="GeneID" id="19897186"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03499"/>
    <dbReference type="eggNOG" id="KOG2659">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073203_0_0_1"/>
    <dbReference type="OMA" id="KMILWAQ"/>
    <dbReference type="OrthoDB" id="2415936at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="1">
        <location>
            <begin position="66"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="229" mass="26336" checksum="54771A43B1AE203E" modified="2013-05-29" version="1">MASRTLLETKRFAPEEWKRRCEQIDPSKTALNYLILNFFIIEGYESSALKFIEEAHLSPPEGLEWMSERMDILNAIYRGDIISAIEKMNEMDPELLDTRPTIHFMLLRLQLIELIRIALYSPDTDLMPILEFAEIHLAPRAPKNAGFLQDLESAMALLCFSSNNLIPALKPLLDLSLRKAVASNVNTAILEAQGLIQESKIKTLLRLWGWSEKKLRKELEFPTFNFTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCD2</accession>
    <name>M7PCD2_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_00009</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871860.1">
        <property type="nucleotide sequence ID" value="XM_007873669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCD2"/>
    <dbReference type="STRING" id="1069680.M7PCD2"/>
    <dbReference type="GeneID" id="19893707"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00009"/>
    <dbReference type="eggNOG" id="KOG0955">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001514_0_0_1"/>
    <dbReference type="OMA" id="WVMDEPP"/>
    <dbReference type="OrthoDB" id="336088at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048189">
        <property type="term" value="C:Lid2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036205">
        <property type="term" value="P:histone catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15497">
        <property type="entry name" value="PHD1_Snt2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.490:FF:000018">
        <property type="entry name" value="Lid2 complex component snt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000012">
        <property type="entry name" value="Metastasis-associated 1 family, member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029617">
        <property type="entry name" value="Snt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47672">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47672:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BAH" evidence="9">
        <location>
            <begin position="69"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="ELM2" evidence="10">
        <location>
            <begin position="382"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="11">
        <location>
            <begin position="554"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="785"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="841"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR11565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1112" mass="129057" checksum="51F59E272F9A3195" modified="2013-05-29" version="1">MLEYNIKEKYPSENIIEDKSYNTKSQELHNPKRKRKNTDKVDHIARIVKINYIQKNGQKEPVCTLTDGSVLYRNDTIYLVSEPPGEPYYLARIMEFTSMNNDPDSSINAIRVNWFYRPRDVQKKTNDSRQLFASMHSDICPLSAYRGKCRIFHKDEIENHDEYRKIPNSFYYDRLFDRYIYRYYEVVPIHKVTNVPDRVKEVLRQEWKYVIVEIGRGKELAMQHRGCKRCGNWCLSIESIRCAVCHDDYHMHCVKPPLLKKPTKGFVWTCTSCSRAEHRRIKANKSLEIPSERQSKTINLRKKSVQNDVDNNNEDSELSDISSISSNITESNNYSEINEKKKYKQPTEQQKAITKLWPYRYLGIHCNIEDVLDYDDRIYPRAASRIGGKHQAVIPEQDESFIEKQQVVVDLRKKRKGKHIYKFSNASEEEILEQTNSEAKMDNTKVNNSKECFPKPSNSKSLFNKNFSFTNEIGTRYVLRGHDHTSIKLFSKPENIPDDLVDNYLNKIKYIAENLSIPHFSTDFQDIALTTLYENQFDINASISSLSFLTKKHLRIPDFNVLELEQFENAISQYGSELSLVANEIPTKSLPEIIKFYYIWKKTESGKKIWGNYSGRRKKEEKLFSSNHNRSILDSSLHLTEDIADSSDDSAYNSEKATLKHKSFICKFCSITKSKLWKRAPGGSFISDKNVVTALCQRCGELWRKYSVRWEPPEEIAKKLSEPGARWRKKKFEEELLKEQHLFEEKEKIEENCDKNGPGKRRRLKTDVKYPKKDIDDSLILKGNSISCRVCELLEPKSILYTCKTCELMVHKTCYGISYVDPNSWICDMCINDKTPMVSTNYQCVLCSVHDCPSLNSNSFFREALKQTSGNNWAHVTCAIWIPELKFTDSSTLQPIEGIGAISLSRWQQVCFICKKVRGVCALCHVCHIPLHVTCAIYAGYTIGFDIALVKGSRKDNAVTIKFSGEFGIMTAAIWCPNHNMKKTIVHAINEYDYEINKYAIKAYVENYKTSMISAKIGNRRINMNAYYGHITPLTIAIKLEELRNLKKDQHSPIKEVTRSCYICETNISPVWWPKNNVSTSTNNLYNAKLLYACHLCYYTMKKKDGKPITKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCE0</accession>
    <name>M7PCE0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcriptional adapter 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PNEG_03577</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875670.1">
        <property type="nucleotide sequence ID" value="XM_007877479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCE0"/>
    <dbReference type="STRING" id="1069680.M7PCE0"/>
    <dbReference type="GeneID" id="19897264"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03577"/>
    <dbReference type="eggNOG" id="KOG0457">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018273_3_0_1"/>
    <dbReference type="OMA" id="YNGNHRP"/>
    <dbReference type="OrthoDB" id="270417at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140671">
        <property type="term" value="C:ADA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071470">
        <property type="term" value="P:cellular response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010520">
        <property type="term" value="P:regulation of reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02335">
        <property type="entry name" value="ZZ_ADA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000087">
        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000115">
        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.90:FF:000008">
        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041983">
        <property type="entry name" value="ADA2-like_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016827">
        <property type="entry name" value="Ada2/TADA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055141">
        <property type="entry name" value="TADA2A_B-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374:SF20">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 2-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22941">
        <property type="entry name" value="TADA2A-like_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25299">
        <property type="entry name" value="ZZ_ADA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025024">
        <property type="entry name" value="Transcriptional_adaptor_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="12">
        <location>
            <begin position="3"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="14">
        <location>
            <begin position="61"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="15">
        <location>
            <begin position="66"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="11">
        <location>
            <begin position="66"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="SWIRM" evidence="13">
        <location>
            <begin position="362"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR025024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMR08139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="453" mass="52834" checksum="56D198F63752C809" modified="2013-05-29" version="1">MPLNKYHCDICALDISRITHIRCAKCNDFDLCIPCFASGSEIGTHKSDHSYRVIEQPSFPIFDKDWGADEELMLIEGLDSYGLGNWQDVADYLGNGRSKEECEKHYHDIYISSPSFPYAKRLPFDIDREEFQKRRKERIGKFSTTDRLVPPQKQKPVVSTPSCHEIQGYMPGRLEFETEYENDAELTIKDINFDEDISENAEDVIELKLTILDIYNSKLDKRAERKKVIFEHGLLDYRKKLANEKKRTKDERELINKTKAFARLQNSRDYDAFVEGLLNELKIRRKIAELQKWRQNGFTTLEQGQKYERDRSQKQLTMKNPLSLMASDRYISRHTKNLTGKLPQSVSQEEYISFNQTKDSISKPLRKPIISNISSASGLHLLTLAEQTLCNQLHILPKPYLVIKDIIFRKLIKTGWQLKKRQARELIKIDISKTSRIVDFMISQGWIKNKDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCV3</accession>
    <name>M7PCV3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_03430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0507 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875517.1">
        <property type="nucleotide sequence ID" value="XM_007877326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCV3"/>
    <dbReference type="STRING" id="1069680.M7PCV3"/>
    <dbReference type="GeneID" id="19897117"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03430"/>
    <dbReference type="eggNOG" id="ENOG502R3ZQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002294_0_0_1"/>
    <dbReference type="OMA" id="HFPMIAR"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097422">
        <property type="term" value="C:tubular endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051248">
        <property type="entry name" value="UPF0507/Ank_repeat_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G09870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="272"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="743"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="994" mass="114709" checksum="2D6F4FFD19C60AB9" modified="2013-05-29" version="1">MKLGYSNIFLDRLFSVDQNNKSFAENLLSQGFSVYEIIILAPIAESLQGLEEGTGIPWIETIDDDFIESHILKSSSGSRYGVYGKIKEFTTINGKTVIIKNDFVYSDKGFSSLRHAKLLYDMLYYSEDLNRHPYLIYFLDRPLVKSCENCFRVSRSFSISNKPAEKITTLQELLKSNSSVLQKINKVLSNSLKKINILEKSDNLNLVNNIQQIIEDAVFSSLKMLRSLNLSSVRAFLNTTSLTEDDIGILVENYVCNETYDIVFPYLKAIYKDNDLELMDSIISMEHIDIYQLGLPFVNNEINDRIYDAINCFKKFEETKIPSEKLSILMKTIHLLVSKTVKIHEEFQRNKNYNENIFQDASNFLKDNLGGDYLIPLLLLVVVRAKLNYLETDFIYMTHFSFLNIRKGEELYAISSLEAVLHHILHQKDKLKAISNYNLILWDSVKSGDINILDSVFKKENPNFISVFFGDFTCTSKISSVLKDIYYYKDINGDSVIMLGIKTKQFSSVSFFLNHSQFSIEILLNDHDIEGSTLLMVAIKFEFKEAINMLLQKLKECSEDEFTNYLAQKDKLGRTVCHYLFHEPYLIMELGIYLSWKSRDKYGQTPLFILSTMYDHPDYKTMFLNAIKIVQLIENNTLNVDDHVDDNGNSLFHTINDSDCLLALLNCKGNINKKNNHGCTPLIYHAKSGKSELVKILVNDKRIDMTAKDKNGFTALHFSAQGNLDVMNLLTEVINIEERTSYTGLTALHIAAQEKSLDCINYLIRNKSANINALDYKGDRPVDLATDQEVIDLLDEYALFMNSSGRNKRMVRAVRAMIENDSTVKFVIKSGFVNSNSKNLITVIRTVEDFKLLYKFFIHEYSESWIPSFHINFLHPCMIPSKPSKSILQAFLNCSNAFLQALLQHSTFSTHELLWEFFTTPEQACIIIERTQKKNMDKDKEIPKKLISIEDVNDADFFFKYAKNNIGNMKHAYYRLYRNLYFLEFSYLGKFEQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCV6</accession>
    <name>M7PCV6_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875521.1">
        <property type="nucleotide sequence ID" value="XM_007877330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCV6"/>
    <dbReference type="STRING" id="1069680.M7PCV6"/>
    <dbReference type="GeneID" id="19897121"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03434"/>
    <dbReference type="HOGENOM" id="CLU_022141_0_0_1"/>
    <dbReference type="OrthoDB" id="5464814at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082904" evidence="1">
        <location>
            <begin position="18"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="538" mass="61153" checksum="6830FEF96BF5D9E2" modified="2013-05-29" version="1">MKIILFFLFTFITYVLSETFGPLGFATLMPPFKPSDIELGFFKNLVSKIYNYDDILLFLTKGDTRSCLRHLSDACKELTRVYGDLSKIGDAVKSICEHQHEACQKLPKVKEDLCRDQSDTYDNLENFFLSGTDCHTAYTKCRLRSRGCSSELSRKCRTLLSHCNYAYNEEHLRVLFANFLGDSTSESFRGKLKKLCNELSFLGDQFVQLCLNPDSLQTSLPGIRDSLRKSSLPFHSYPKMSIGALLDASELDGGLYSPKNNPTVDPSYFMGYLLGQHRSTSFASDCVKISQKCLGLDFFPQSAYFCDAETAVSLNSLCEKTAVALLEQHIPNLKKELEYKLSDEQYPEVISLSGIDVDFCKDFLGPCSYLENLDSTLYSLCDLLKGRCAYDLEIASSLSIYEYYFREVFLKKDPNTHIDLCQKVLPRICGFTLNTTVDFLTFCLNPAHTCFALATLLNLRCDRIKEGMTQVDPSHKDCVTKLREAETYGSLCTENEEYVKFLTTCYETYFDEYIKELANSKLKKLTPENKFGKLNDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCY3</accession>
    <name>M7PCY3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_03142</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Vacuole membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875202.1">
        <property type="nucleotide sequence ID" value="XM_007877011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCY3"/>
    <dbReference type="STRING" id="1069680.M7PCY3"/>
    <dbReference type="GeneID" id="19896829"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03142"/>
    <dbReference type="eggNOG" id="KOG0232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085752_1_2_1"/>
    <dbReference type="OMA" id="MGVMKPD"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="92"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR08299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="161" mass="16293" checksum="0A7F9EB0EF19E235" modified="2013-05-29" version="1">MTTELCPVYAPFFGVLGCASAIIFTSFGAAYGTAKSGVGISSMGVLHPELIVKNTIPVVMAGIIAIYGLVVSVLISGGLKQQLSLYTGLIQLGAGLAVGLSGLAAGFAIGIVGDAGVRGTAQQPRLYVGMILILIFSEVLGLYGLIVALLLNTRATDTTCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M7PEL2</accession>
    <name>M7PEL2_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_02686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874710.1">
        <property type="nucleotide sequence ID" value="XM_007876519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PEL2"/>
    <dbReference type="GeneID" id="19896377"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02686"/>
    <dbReference type="HOGENOM" id="CLU_2528387_0_0_1"/>
    <dbReference type="OrthoDB" id="5396146at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="84" mass="9992" checksum="F17CD4CF68E07DD6" modified="2013-05-29" version="1">MDEDSLKLKNIVSKTIRSFKTFLISIFNYTNTNLYFLKRTNQITIDHYNLIENSIKDISNNNESLSYICTIQYLITFQCINKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M7PG56</accession>
    <name>M7PG56_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02386</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874392.1">
        <property type="nucleotide sequence ID" value="XM_007876201.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PG56"/>
    <dbReference type="STRING" id="1069680.M7PG56"/>
    <dbReference type="GeneID" id="19896079"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02386"/>
    <dbReference type="eggNOG" id="KOG0922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_5_11_1"/>
    <dbReference type="OMA" id="CHENFLH"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000615">
        <property type="entry name" value="pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000145">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF118">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="138"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="326"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="61"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="753" mass="86777" checksum="05AB4369A845D27F" modified="2013-05-29" version="1">MKRTKRARNQGIHYKFNEKEDFEVIEEDSSNFSPKKNMKNDKKRRIYHTIFHEKRIKRIDKKKEENTIINEENEGENIKENSEIKKIDILEVEQSKNTNGIKNLIKEKKSKKELYQRKKELLKDRMKLPIWTARLRLIKEMENSRVIILLGEPGSGKSTQLPQFLLKCNYTKNNRIAVTQPRRIAAINLAKRVSEEVGTNLGERVGYSIRFDDCSSLDTQIKYMTDGMLLRELIGDPLLSIYSTIILDEAHERTLITDMLLGFLKKIIKLRPMLRVVIMSATLEAERFSTFFDNAKIYFIKGKEHPVNIYHTLQPENDYVDAVLRTVFQIHINEPEGDILAFLTGQDEIESLEISICHYAKQLEENVPKMLICTLFSALPQNIQQKAFIKTPSNTRKIILATNIAETSVTVKGVKYVIDTGLEKAKKYNNRLGIEVLHIGPISKSSARQRAGRAGREGPGRCYRLYTKSEFKKLKNTSTPEIKRANLSFAVLTLKARGENDVINFDYIDPPSHNSLLRSLEQLYSLSALDEKGEITKLGYDMSLIPLNPQLARVLIAAANDYDCLSCVIDIIACLSTENLFMSFQNKKNEANNAKMKFFNRNGDHITYLNVLRQFIEIRKNESMAKTWCYQNFINFRAITTIMEIRKQLMKHCKNASMKIEFSNKIDTELILRCFLTGFLMNTALLQADGNYHTVMGNTIVYIHPSSVLFNKKVEAILYNNLIFTTKPYVHIVSMIKSDWLRSTSQISKNNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7PGU7</accession>
    <name>M7PGU7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U1 small nuclear ribonucleoprotein C</fullName>
            <shortName evidence="9">U1 snRNP C</shortName>
            <shortName evidence="9">U1-C</shortName>
            <shortName evidence="9">U1C</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_01871</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. Interacts (via N-terminus) with TIA1 (via C-terminus); thereby promoting spliceosomal U1 snRNP recruitment to 5' splice sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">U1 snRNP is composed of the 7 core Sm proteins B/B', D1, D2, D3, E, F and G that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins U1-70K, U1-A and U1-C. U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the U1 small nuclear ribonucleoprotein C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873845.1">
        <property type="nucleotide sequence ID" value="XM_007875654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PGU7"/>
    <dbReference type="STRING" id="1069680.M7PGU7"/>
    <dbReference type="GeneID" id="19895565"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01871"/>
    <dbReference type="eggNOG" id="KOG3454">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079697_2_0_1"/>
    <dbReference type="OMA" id="QMRPPLM"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000059">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03153">
        <property type="entry name" value="U1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017340">
        <property type="entry name" value="U1_snRNP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148:SF1">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037969">
        <property type="entry name" value="U1_snRNP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="11">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="125"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR09684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="158" mass="17232" checksum="8C21C92A636968C7" modified="2013-05-29" version="1">MPRYYCDYCDVFLTHDSASVRKAHNAGKNHLTNVREYYQEIGHEKAQNVIDSITKAYENQPVMLPLPGMFPPLIPGMPPMPISGVPGPLPPHPGMLDTPLPPPIPGMPFPPPFVPPSRLNLPFPGGFVPPSVPPPGISQIQPSQQSSTFLPQNMQHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M7PHQ8</accession>
    <name>M7PHQ8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="2">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01752</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873716.1">
        <property type="nucleotide sequence ID" value="XM_007875525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PHQ8"/>
    <dbReference type="STRING" id="1069680.M7PHQ8"/>
    <dbReference type="GeneID" id="19895446"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01752"/>
    <dbReference type="eggNOG" id="KOG0903">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002446_2_0_1"/>
    <dbReference type="OMA" id="TQDYVDV"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140504">
        <property type="term" value="P:microlipophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042998">
        <property type="term" value="P:positive regulation of Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050714">
        <property type="term" value="P:positive regulation of protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05168">
        <property type="entry name" value="PI4Kc_III_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000016">
        <property type="entry name" value="PIK1p Phosphatidylinositol 4-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021601">
        <property type="entry name" value="Phosphatidylino_kinase_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057754">
        <property type="entry name" value="PI4-kinase_beta/PIK1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049160">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF22">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21245">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11522">
        <property type="entry name" value="Pik1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="6">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="5">
        <location>
            <begin position="595"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="881" mass="101677" checksum="303C385CC05A312E" modified="2013-05-29" version="1">MNGPKASGNDLLFRFFESTHFTSHLCVAYLARYPDNIGIHHYLCSKLKEFSATEIEFFLPQLCHLAVNLNTESVALEIFILDQCKSSSHIALMVFWLFQAHFTDLLKTPEYVSFRTCKRMFNKIQHIIFGEREIYDLNDFKVRENIFPSILLSSVIIGSASVPFLSKTVGPIAIAQARQYRPQSRETDKGMFQHTMFSDFFQTPRENVSESLSNSISMVQLDRNLSQDKQNLHEYSQFSNATSQETLLLSLYLYSKKSLLSDFYAQNYEILSSVSPRKQSLLLQTQYFRYETAFLQALQDISSRLIIVPELARLSALRAELTLLNSYLPADICIPSLCTATASYPIHHRIVRINSTEAIVLNSAKRVPYLLIIEILENDLSFDPEKMENKEKIAKILSNTGKSKRLFDLLHDPILSHNFDAELHKVNQKTDIESDLGDISVLSIYDYADDMLYKKTDLNGHSDTSLPEFSKLKHINHSFDPRLKFPQYQTETNMLSKENNSLSPFIDENSIIATYMRAAATMLAQLDSDGNKRPKVETSAIKSKIIKEMQNLEEKRINMNNCENFIDARMNNIKYNRIEEKNRNSTMKIFEEEWSVKVERIRKSSPYSHLPNWNIISVIVKTGSDLRQEAFACQLIYACQKIWDEYNIPVWVKRMRILITGNDSGLIETIINSTSIHSIKKKIIQSFSESSKGKVLSLKDYFLKMYGDTHSVQYKAAQDCFMRSLAAYSLICYIFQLKDRHNGNILLDTEGHLIHIDFGFMLTNTPGNVGFENAPFKLTTDYVNILDDRFDDWKDLMKQAFKALRKKAEDLILLVKIMQNESKLPCFSSGELTSIQFQQRFQLHLSETEADEFMESLITKANASLWTRLYDQYQQLTQGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7PHU2</accession>
    <name>M7PHU2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sister chromatid cohesion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01783</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873751.1">
        <property type="nucleotide sequence ID" value="XM_007875560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PHU2"/>
    <dbReference type="STRING" id="1069680.M7PHU2"/>
    <dbReference type="GeneID" id="19895477"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01783"/>
    <dbReference type="eggNOG" id="KOG1525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002562_1_0_1"/>
    <dbReference type="OMA" id="YPPAYNM"/>
    <dbReference type="OrthoDB" id="200660at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099115">
        <property type="term" value="C:chromosome, subtelomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140463">
        <property type="term" value="F:chromatin-protein adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051456">
        <property type="term" value="P:attachment of meiotic spindle microtubules to meiosis II kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19953">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039776">
        <property type="entry name" value="Pds5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663">
        <property type="entry name" value="ANDROGEN INDUCED INHIBITOR OF PROLIFERATION AS3 / PDS5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663:SF0">
        <property type="entry name" value="PRECOCIOUS DISSOCIATION OF SISTERS 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1173"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1177"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1202"/>
            <end position="1214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1214" mass="140491" checksum="88269419DAEDBCBA" modified="2013-05-29" version="1">MARLSFKETLISKGTSRLSVNELLKRLRVLQSELAEHDQEQIERGSLDGIIIELVNDGLLNHKDKGVRAYTACCLADILRLCAPDAPYTPSQLNNIFELFVGQLKNLFSSELPYYAQSFYLLESLSQVKSVVLIADLSNGHVLTMELFRIFFEMVTPEQPRNVIIAMVDILAQLIDESVTLPPKVIDIMLAQFTVTSSKKNHSFGLKTERPPAYIMAKQLFNICAERLQRYVCQHFTDIVFEANQSIERDPQAELDKAILEEVEKVHHLVYELYIVSPSVLENIMPQLEQELMVENVALRLLSTSTISEMFSVKEQKVDFVKEYPSLWKSWVSRGNDKNSSIRIRWLEGLFNVLINFGYSPEAMAVAIEGILSKHVDIDEKVRMTVCKMIGSLDYKIVSERIPSNVLEALSDRCKDRKHMVRIEAMHCLGKLYYIAYNDILKNSNSTTEWFLSIPSRILHTIYINDKEINALLEFVLYQYILDYTEMDDFKRTERMLFTFKNLDGRAKHAFLSLGRNQPKYAKITEYYLSICEKYNGGVISDNEKKVLAALKDAITRLKSLYGDSSKAELDFEKFSRLNDRRLYKLLRDCMNLLSDYKQIQKSQKEFFKRIEQSPTLVETFKILIFKISPMLYNKSVISPIIEYARSNKNMLADTACELLKEISLVQPSVYKAHIEEISSLIKEHDIKSNISYVDTLKVYAQFTTSFSHDITTDSKLLKALTFFALKGTPAESKQAVFILLHSVNKEKFTRDLIIKIFDELTIDSEYFLTRLSALSQFVLYAPEEMEPRADQYTSFFIKEVLLVNLISDDSSEEDWVEKDVLENECKAKILALKTLVNRLRANVNADGIHELAKPVFRLLASILTNMGEISKERNTPARFQSHIRLAAGRLFLKLSSYSVFEEMISVEDFYKMALLVQDPCFQVRYNFVKKLMKGLNLNKLTVRYYVPIFLMAHEPEEEFKQEVVKWIKLCTSAYRVREIFTIEYAIVRFIHFLSHHPDFSTDSDDLIDFAKYINFYLELVATSDCLSLLFHLVQRIKQVYDLISPENSDRLYVLSDLSQALIRIVAASNSWTIQIYPKKLKLPIELYAPLTNVKVATEIAQRNYIDKDIEEQLLSLTKSLRLIRKRKSIDEKQIEPIKRRFSKNTIKNQRKKKLENASVPLRRSRRVLQAVNYVENGDDDDDDEMMEEEINDRESDESDVQLDSLDTDSSLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7PIT8</accession>
    <name>M7PIT8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="3">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01616</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873574.1">
        <property type="nucleotide sequence ID" value="XM_007875383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PIT8"/>
    <dbReference type="STRING" id="1069680.M7PIT8"/>
    <dbReference type="GeneID" id="19895311"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01616"/>
    <dbReference type="eggNOG" id="KOG2529">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032087_4_2_1"/>
    <dbReference type="OMA" id="PWRHVTK"/>
    <dbReference type="OrthoDB" id="9995526at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767:SF2">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE TRUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="TRNA-PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase II N-terminal" evidence="6">
        <location>
            <begin position="58"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="315" mass="35847" checksum="99E05545CD2536EA" modified="2013-05-29" version="1">MNKGGIIAINKPSGWVCTHILNELEKILRKSYLYNQLVDISQEQAHKRRRKSKDSKYRKIKLGHGGTLDPLASGVLVIGIGKSTKKLKKFLNCTKEYEATALFGYSTDTYDSNGKILKCMPWSHLTEDKVTKALENFKGNILQKPPIYSALHMKGKRLYQYLREGIELPEEIKPQPTTDDAIDISSNVLQEQGAMNYKSEKRNLFNSTNEIKISDNLSNNVDNEEQKTSNIRSSIKRKAPAVKFRIVASSGTYIRSLIHDLAIFLDSAAHIVELVRCRQGKYILNENTIDWSKFQNGDWEKDFLEAISLEDDTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7PIX8</accession>
    <name>M7PIX8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PNEG_01119</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="function">
        <text evidence="15">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873034.1">
        <property type="nucleotide sequence ID" value="XM_007874843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PIX8"/>
    <dbReference type="STRING" id="1069680.M7PIX8"/>
    <dbReference type="GeneID" id="19894816"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01119"/>
    <dbReference type="eggNOG" id="KOG0070">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_9_3_1"/>
    <dbReference type="OMA" id="HYYANTN"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000554">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 15" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU369003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMR10404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="184" mass="20893" checksum="BD0E9A5FA321DFC3" modified="2013-05-29" version="1">MGLSISRLLQGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGIIFVVDSNDRERVSEAREELSRMLNEDELRDAVLLVFANKQDLPNAMNAAEVTDKLGISTMRNRTWYIQATCATSGDGLYEGLDWLSMNLKKRCSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJF4</accession>
    <name>M7PJF4_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Eukaryotic peptide chain release factor subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01299</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873223.1">
        <property type="nucleotide sequence ID" value="XM_007875032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJF4"/>
    <dbReference type="STRING" id="1069680.M7PJF4"/>
    <dbReference type="GeneID" id="19894996"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01299"/>
    <dbReference type="eggNOG" id="KOG0688">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035759_2_1_1"/>
    <dbReference type="OMA" id="GPGTEKM"/>
    <dbReference type="OrthoDB" id="10254527at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009302">
        <property type="term" value="P:sno(s)RNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.960.10:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000006">
        <property type="entry name" value="Peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="entry name" value="eRF1 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03676">
        <property type="entry name" value="aRF1_eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="5">
        <location>
            <begin position="5"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="432" mass="48788" checksum="B94C938CFDD81445" modified="2013-05-29" version="1">MNSNSNDVEKNVEMWKVRKLIKSLESARGNGTSMISLIIPPKDQVSRVNKMLGDEYGTASNIKSRVNRLSVLGAITSTREKLKLYSKVPPNGLVIYCGEIITDDGKEKKLSIDFEPFKPINTSLYLCDNKFHTEALSELLESDQKFGFIVMDGNGSLFGTLCGNTREVLHKFTVDLPKKHGRGGQSALRFARLREEKRHNYVRKVAEVAVQLFITNDKVNVAGLILAGSADFKTELSISDMFDSRLTSKIIKIVDISYGGENGFNQAIELVSDILSNVKFIQEKRLIQKYFDEISQDTGKYCYGVEDTLKSLELGAVETVIVWENLDVIRWTLCDSKGDTVIVHFTKEQCEKNREPFIDKETGNEMEVVSSIPFLEWLTEKYKDFGANLEFITDKSQEGNQFCKGFFGIGGLLRYKLDFSTIAMDSDDYYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJX1</accession>
    <name>M7PJX1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH myb-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872804.1">
        <property type="nucleotide sequence ID" value="XM_007874613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJX1"/>
    <dbReference type="STRING" id="1069680.M7PJX1"/>
    <dbReference type="GeneID" id="19894591"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00893"/>
    <dbReference type="eggNOG" id="ENOG502QRT9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_388362_0_0_1"/>
    <dbReference type="OMA" id="VEKRCIN"/>
    <dbReference type="OrthoDB" id="3366990at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052833">
        <property type="entry name" value="Telomeric_DNA-bd_trans-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47807">
        <property type="entry name" value="PROTEIN TBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47807:SF1">
        <property type="entry name" value="PROTEIN TBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="2">
        <location>
            <begin position="634"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="539"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="711" mass="82952" checksum="BACA4FF30AB573C0" modified="2013-05-29" version="1">MSEKDPQELLETLSKHELEDQLKEQLEHQLKVFHEEEIISNDSSYEESVLKDFSDLEIPNSDNILFNEYLPTLSPFTATTEIGTKNVENDVGNTSDYVNTLEERNNIGKGDKINEIEDIDILREMLPDLQYHSERIIQLLIPKTSFIAHVKQATTKGTKIYKKKEFLLQTLKLIALEYTKSSYIDISPFSHYLPNNEIYILFLANAALLLSELYGSFSIPPTLEDLKKRHNSLCEIDHWFPFIFNITFWQAYMQIIELRTQLFIYAIWLNRVSDDDIGSIQFKEDNELKRCFMDENGRFKRWEEGGKEYNDACAQRIKKIQNIRRLPTSLETLIQTFPWYHFIKLMIEFIQRNILNISNKSEIADKSNTQAYQNKKTSNIIPLNQSFSMDFQKNNFISPLEQNKEYSFNSENEGEISASDIKHLSQIVLDIDNNDNTKKTQKSDNKNKKHKKSFFDKQSDYRKIIWDSQNENSESIDNSLIHNILDKPATSIKENISYNEKKRKYDEQNESNSVEHENLSNTTYSKNILRTDTILSNTLSNSSSHSELSNLPPSSPPVIPSASAQAAMELYKKSLTIQRLGSTLSTDENNLEPFDDTKHIKEKSNTDQYKEYIAVKQHLRINRFRKKEYKPQHRVPWSETETNCLIKAIQEYGSQWSFILSLYGPNGTLSQDLAERGQVQLKDKARNIKEEYIRARWKLPPGFETVTCKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7PKE9</accession>
    <name>M7PKE9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoinositide 5-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01075</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptojanin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.36" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872986.1">
        <property type="nucleotide sequence ID" value="XM_007874795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PKE9"/>
    <dbReference type="STRING" id="1069680.M7PKE9"/>
    <dbReference type="GeneID" id="19894772"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01075"/>
    <dbReference type="eggNOG" id="KOG0566">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003016_2_1_1"/>
    <dbReference type="OMA" id="ICQQRFY"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990651">
        <property type="term" value="F:inositol-1,2,4,5,6-pentakisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990649">
        <property type="term" value="F:inositol-1,2,4,5-tetrakisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052659">
        <property type="term" value="F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052658">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990650">
        <property type="term" value="F:inositol-2,4,5,6-tetrakisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990640">
        <property type="term" value="F:inositol-2,4,5-triphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990648">
        <property type="term" value="F:inositol-4,5,6-triphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030487">
        <property type="term" value="F:inositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034485">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000029">
        <property type="entry name" value="Inositol polyphosphate 5-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF257">
        <property type="entry name" value="PHOSPHOINOSITIDE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SAC" evidence="10">
        <location>
            <begin position="142"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1007"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1007"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1020"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR10929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1029" mass="118305" checksum="6181FFD437C304A1" modified="2013-05-29" version="1">MKCFRRNSPSSIALKVGSDALVFQTCGKSLESQTCIAKFCKWDDIDYSEFFLATSKVIYGCMGLISIENNVFICLITGYSQIASVRAMETINRIHDVEFLCLDSSWDNFSRNINENNSESNIGELFDSFSKQNEPEHPCESIRKLLLNGSFYFSSNFDLTRRIQDRVESDFCIDKFDDQFLWNSYMISELFIFRSRLVESEKYVFDKGGFLVYVIRGFVGTVICKIGSLTSSLTLISRLSCKKAGTRFNSRGIDDDGNVANFVETETLLTINNFCFSFCQIRGSVPVFWEQEGIQVFGQKVEVTRPFEATQSSFEKHFESLISKYGYVHIVNLLSQNGGERLLLNSYRQHIDSLKGNLFHLICCSEFDFHAEVKNGGYDQASKILYYVDDNIKNFSYYLEDVGKKSIMLQQGGVFRTNCLDCLDRTNLVQALISKYSVMLFLKYLEICPEIFPWSEHSTIWADNGDALSRIYTGTGALKSGFTRRGKMSIVGVLEDATKSVSRMYVNNFQDKGRQLNIDLLLGRLVNQKTVHIYDPINEFVTMELEKRANEFSTIKNISIFVGTFNLNGKKRTDDLSSWLFPNGRKYKSDLVVIGFQEIIELTPQQIISVDPYSKKIWESDLYEILNRDKNEYVLLRSAQLVGSVLMIFVKESSVPFIKNVESAVKKTGLKGMSGNKGAVAIRMDYGNTRICFVTAHFAAGRFNYDERNRDYFTIVNGLNFRRGRAITDHDIIIWLGDFNYRINMSTEEVKEYIKINNFGKLYENDQLNLHMNSGSVFPNYSESQITFPPTYKFDNGTNNYSTSEKQRTPSWTDRILYKGSNLRQLSYNSSPLTFSDHKPVYAHFEASIRIVDEEFKERLRKDIYNFRKLKTEESDNNGIIRDFVDLEDKYYLSNKRDSLPSNIDIEEISLENNIPVKVTVPMQRTDSSPTFRNFLGSYGTAKLDSIENNTEESLSMISNARFHAMEKPKLPPRPQISEVSSMNESQPLYETFVAELAEKFSKMSEKQSNVESFSITHKSLNERFQRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7PKF3</accession>
    <name>M7PKF3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <ecNumber evidence="3 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01079</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="3 7"/>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872991.1">
        <property type="nucleotide sequence ID" value="XM_007874800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PKF3"/>
    <dbReference type="STRING" id="1069680.M7PKF3"/>
    <dbReference type="GeneID" id="19894776"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01079"/>
    <dbReference type="eggNOG" id="KOG3243">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089358_2_0_1"/>
    <dbReference type="OMA" id="HYDTVCN"/>
    <dbReference type="OrthoDB" id="2965at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="entry name" value="Lumazine/riboflavin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058:SF0">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE DMRL SYNTHASE LUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="Lumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="190" mass="21490" checksum="D2AE6ADEBB90A2F4" modified="2013-05-29" version="1">MLIKEPEPFKDELDGSSLRIAIVHARWNIFAVSPLVEGAKKALIKHGVRPENIYIESVQGSWELPFSIYKIIEASKLKENKCLKSSKVDRKPETSDSLFKQENIETLRQIKGEFDAVIAIGVLIKGETMHFEYISDSVSHGLMKVQLDTGIPIVFGILTVFNKEQALERSGMSGEFRKNHGKCVFLFFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7PKQ4</accession>
    <name>M7PKQ4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872541.1">
        <property type="nucleotide sequence ID" value="XM_007874350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PKQ4"/>
    <dbReference type="STRING" id="1069680.M7PKQ4"/>
    <dbReference type="GeneID" id="19894339"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00641"/>
    <dbReference type="eggNOG" id="KOG1102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003663_0_0_1"/>
    <dbReference type="OMA" id="ANFETAM"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000023">
        <property type="entry name" value="TBC domain-containing protein C1778.09"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="207"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="462" mass="54441" checksum="9BC9387BEFF8924B" modified="2013-05-29" version="1">MTLRLKITKEDFLVIKAKDLMAETNPIQIQQTGSLYQDTSSKDYESEEKGQGSSLVCKNRSSYDDIILSLQIKSFYEINEEICLEESSSEKNMIDNSNVDRYGFFSTRQKLPEEKNKIISQLRFLEFGNGFFRRKKRIILEIPHDFCFDQLLNQDNLTWYKEGYDANKKEINRIEKWRSMAESFRINGNTEYSFLNTKKLVNRVFKGIPDSWRSAAWYAFLSHSVKKNKSKYTDCELKLKYHELLQLPYTHDFQIDLDVPRTINGHVFFQRQYRDGQRLLFRVLHALSLFYPEAGYIQGMASLAATFLCYYDEESAFIMSVRLWEERGILSIFSNSFKNLFLCFNELQTRLLKTKVGKKLFSLGIDISTFTTKWYLTLFNNSLSFSTQLRIWDVFIWYDANEKNKLEILHITAMSLILGMKDTLMKANFETAMRLLTSRIHVIDDDAFLNLIKSQWKLIKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7PL93</accession>
    <name>M7PL93_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00823</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872730.1">
        <property type="nucleotide sequence ID" value="XM_007874539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PL93"/>
    <dbReference type="STRING" id="1069680.M7PL93"/>
    <dbReference type="GeneID" id="19894521"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00823"/>
    <dbReference type="eggNOG" id="KOG4317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1816600_0_0_1"/>
    <dbReference type="OMA" id="TIKCYRN"/>
    <dbReference type="OrthoDB" id="18412at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23024">
        <property type="entry name" value="zf-HIT_ZNHIT2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039646">
        <property type="entry name" value="ZNHIT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15555">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 2 PROTEIN FON -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15555:SF0">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR11234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="142" mass="17392" checksum="BB697E872EB81918" modified="2013-05-29" version="1">MNNRKILCQICNNQYGKYICPRCNQRYCSLICYRSQIHLRCSEFFYKDNVEQEIKNRKITKKEKTEVLHFLSKYSYNEDFKNFKFLDDNKKLSEKIEKSTLKNRMKDIDVENASFEEIWERLESNEREEFVHLAMAYNNDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7PLY0</accession>
    <name>M7PLY0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent RNA helicase SUB2</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">ATP-dependent RNA helicase sub2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PNEG_00489</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 also plays a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the DEAD box helicase family. DECD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872375.1">
        <property type="nucleotide sequence ID" value="XM_007874184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PLY0"/>
    <dbReference type="STRING" id="1069680.M7PLY0"/>
    <dbReference type="GeneID" id="19894187"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00489"/>
    <dbReference type="eggNOG" id="KOG0329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="OMA" id="YAHVEPK"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17950">
        <property type="entry name" value="DEADc_DDX39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000111">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000168">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase 56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 21" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="80"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="267"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="17">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EMR11474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="432" mass="48924" checksum="16FDB0C24CAE4077" modified="2013-05-29" version="1">MASNDDLIDYEEEELTPHTSVATVIGAGGTVNGDKKSEKKGSYVGIHSTGFRDFLLKPELLRAIIDCGFEHPSEVQQVCIPQSILGMDIICQAKSGMGKTAVFVLATLQQIEPVDGEVSVLVQCHTRELAFQIKNEYARFSKYMPDVRTCVFYGGTPVRNDIELLKNKEKCPHIIVATPGRLNALVRDKALRVGSVKHFVLDECDKMLEAIDMRRDIQEVFRATPHQKQVMMFSATLNNEIRPICKKFMQNPLEIYVDDETKLTLHGLQQHYVKLEESAKNRKLNDLLDILEFNQVVIFVKSIQRASELDRLLRECNFPSICIHGGLPQEDRIARYKSFKDFNKRICVATDVFGRGIDIERVNVVFNYDTPADADTYLHRVGRAGRFGTRGLSITFVSSSTDAEILDKIQERFEVNITELPEHIDVSSYMNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7PMM7</accession>
    <name>M7PMM7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">WLM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00153</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872014.1">
        <property type="nucleotide sequence ID" value="XM_007873823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PMM7"/>
    <dbReference type="STRING" id="1069680.M7PMM7"/>
    <dbReference type="GeneID" id="19893851"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00153"/>
    <dbReference type="eggNOG" id="KOG1558">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_984895_0_0_1"/>
    <dbReference type="OMA" id="GTLCEFY"/>
    <dbReference type="OrthoDB" id="261960at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053000">
        <property type="entry name" value="WSS1-like_metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WLM" evidence="6">
        <location>
            <begin position="4"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="5">
        <location>
            <begin position="269"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="38746" checksum="F8084981C5C6D749" modified="2013-05-29" version="1">MEFLKGIPSLSPIDKCVSLKSKKRNQEAYDLLKKIESLVMPIMKSRSLEVSVLAEFFPKNDALLGLNINRGSKICIRLRMKDDENMFYPLDYLIEIMLHELTHNVYSSHDAKFYGKLFFYMLNELNLEFNQLLCSGNIKNQFYSKDYKVGENISRNSLYHKTRVLEEKKLSNTLTNGSGSRLGGTRNVDNKPLRDLIREATEKRIKNLKWCMFESNIVIEDDEIYDGPKNDIFSSELLESGSDLNNPQLKKKIKVLTSKPKFFQKDIIPEDLWSCTFCTFKNNGNYLQCEACLSERSFNVFEFFNKKWNCIICSNLNEKQQYSCEFCNTIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7PMP3</accession>
    <name>M7PMP3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor U2AF subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">U2 snRNP auxiliary factor large subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_00168</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for the splicing of pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the splicing factor SR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872029.1">
        <property type="nucleotide sequence ID" value="XM_007873838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PMP3"/>
    <dbReference type="STRING" id="1069680.M7PMP3"/>
    <dbReference type="GeneID" id="19893866"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00168"/>
    <dbReference type="eggNOG" id="KOG0120">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021795_2_0_1"/>
    <dbReference type="OMA" id="MTQWDIK"/>
    <dbReference type="OrthoDB" id="10266058at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12230">
        <property type="entry name" value="RRM1_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12231">
        <property type="entry name" value="RRM2_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000074">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000097">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006529">
        <property type="entry name" value="U2AF_lg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01642">
        <property type="entry name" value="U2AF_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="214"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="323"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="438"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR11734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="531" mass="60711" checksum="20DD81B4657E0930" modified="2013-05-29" version="1">MKHNDLNGTSRDRRGERDERRGDRDRSRRDGLIGREERHHHYSERPSRHERGDERDREHSHRRSREDERRRRRRDEEYTQNGRNHDGGHSSGAGRSERDERMDRMIRDRRTGREEWHRRSRSPRYRGREPTPDLTDVVPINERRRRMSMWDVKPTGYEAITAEQAKMSGLFPLPGAPRQSMMDLSKLSTANKGPAAMNIPTPLALQPLQSRQSRRIYVGNIPQPIDEEHLVNFFNDTMSSLNVTTSGDNPVVSAQVNHEKAYAFLEFRQPEDATVAIGFDGISYMDSSLKIRRPMDYIIPQMPSDDGSYVPGVISTNFIDTPNKIHIGGLPIYLDEEQVIELLKSFGELKAFNLVKDAVTNESKGFAFCEYVDPDVTDIACEGLNGMELGDKTLVVKRASIGSRQKAISTSGGGISSITMLAEEEGHFRPTRILQMFNMVTPEELQDDDEYEEISEDIREECSKYGKVLDLKIPRGIGGSRSNFGVGKVYVRFETEASCLKAMKDLAGRKFSDRTVLTSFYPEENYEVGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWT9</accession>
    <name>A0A0W4ZWT9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminopeptidase P N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_04345</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="KTW32844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875472.2">
        <property type="nucleotide sequence ID" value="XM_007877281.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWT9"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZWT9"/>
    <dbReference type="GeneID" id="19897075"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04345"/>
    <dbReference type="OMA" id="DSYFWYL"/>
    <dbReference type="OrthoDB" id="4215474at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF4">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="7">
        <location>
            <begin position="54"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KTW32844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="484" mass="55384" checksum="C147943BAE81CFA6" modified="2016-03-16" version="1">MIVNIISYRTRHVLHFIFYANRCFSINKQFSLYGQAIYTTHPHLIKPTELTPGITAAEYATRRSQLASTLPAHSLVVLIGAQIMYKTTSTFYVFHQYPNFFYLTGVNEPYSIFAMERDHSFNGFKSYLFLRNKNPEEERWEGPRTGIEVAKDIFFIDEVYDLQEAENILSKSIHRTTQIYAEIPFNINISSIKPKSNASDILDKLCKRLLSYPILPITPWIHQLREIKSEAELSLMEQAASRSAAALNATMQVSPETEGLLWAKLSYELKKRDCDEAYVPVIAGGKNALIIHYTMNNMQLRNGDLVLVDAGGEYGNYVTDITRTWPVNGFFSPQQKDLYQAVLNVQKACIQLCSERHALSLDMIHQHSAELLKIELKQLGFNISHSDLYDILYPHYIGHHIGLEVHDCSKLPGKRLLKNNQTITIEPGLYIPDLPKFPKHFRGLGVRIEDSIQVGKENPIILSKDAVKEIVDIEKICNKYKEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZX37</accession>
    <name>A0A0W4ZX37_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_04256</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="KTW32934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872487.2">
        <property type="nucleotide sequence ID" value="XM_007874296.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZX37"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZX37"/>
    <dbReference type="GeneID" id="19894289"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04256"/>
    <dbReference type="eggNOG" id="KOG0691">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RPALMDK"/>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000028">
        <property type="entry name" value="DnaJ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052814">
        <property type="entry name" value="Peroxisomal_DnaJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006:SF1">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="7"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KTW32934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="410" mass="46686" checksum="3ACA0585896381A4" modified="2016-03-16" version="1" fragment="single">VGVIDREYYDILEVDPLADNLTIKRAYRRLAIRFHPDKNPDNPEESREKFQKIGEAYQVLSNPELRRKYNMYGKKEATPDQGFCDPSDFFANLFGGEAFVDLIGEISLIKDLTKALEIAEMEKKPKNEDTSVSIKSNIALSFSDKKTITCSSPPSPVSTISETEKNTQKNYKKRGLTKEQQEELLAFEKEKASVRKKRVEHLANKLVDRLNIWTESTKDELTTRAFQEKIKYEAENLKMESFGVELLNAIGVIYIQKGTSLLRSQKFLGISGIFSKIKEKGIIAKDIFGTISSALDAQMTAEQLSKLEEKGEDWDSIRKIELEKEMTGKILLASWRGAKFEVSGVLRRVLYSTKDVCDKVLSKSIPLEKRIERARALIMIGAIFCETQPDPGDEGRVFEELMRNSTKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7NI01</accession>
    <name>M7NI01_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_03359</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875441.1">
        <property type="nucleotide sequence ID" value="XM_007877250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NI01"/>
    <dbReference type="GeneID" id="19897046"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03359"/>
    <dbReference type="eggNOG" id="ENOG502QWKV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006409_0_0_1"/>
    <dbReference type="OMA" id="IDDYEVM"/>
    <dbReference type="OrthoDB" id="5569911at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056703">
        <property type="entry name" value="DUF7801"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029191">
        <property type="entry name" value="Uds1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25078">
        <property type="entry name" value="DUF7801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15456">
        <property type="entry name" value="Uds1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Up-regulated during septation protein 1" evidence="2">
        <location>
            <begin position="59"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7801" evidence="3">
        <location>
            <begin position="542"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="342"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="656"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="727"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="761" mass="89393" checksum="4D32D271D316FF9B" modified="2013-05-29" version="1">MNTVSYDKELKTKYGNVVPPAKSLLDTTEFYDNQEKNRLSNYTDSQILPLVNEQDEIGMQYLSSNAVFDSKEYEILSLEDVEKLKKEKHVLLNRIETVRRTLALESKLREAAQSLSRLHSNRGKRISRQVEDQLLISNSKIEEAAEELWRLQKNEHEISIRLLKHTAGVLRYALEKHTMSGYVSNLLQEKKPIDLYDFGELHFYRSVNNTELSENTESRKNKINDNISYTLVEIQKRLTISNNQLKSFLAGGKHINNQYTENQLHLNYNSIDVLEILSELEDTICNVHQQYLELKEASLLQIAEFQKNYKYIWDKTDIEDCPIKSYSIEHGQFSIDSLISRVELLTSELSKSKKMYKNLLEKEKVQEENNITAINSLKLEYENKINDLDIDLSKAKKTIGEFVVRESSISSELYDANEKISEYQQIIDSLNKEIEITKNDKEDDYRKWQDDQKNLENIIEDYAKQLKDNEIKFQELNNNYSNLLKSHSDSLSDFQKKIKQKESTLELLQDEISKLRNINAILEEKIQSLQSQYKDEQLACENKANETIRNLENDIVKLSTEITILKTEIDTIYNSKQQEMEKTVITQQFENENNSINQETKISESSKSTQENKLLEITEKNKMMSEKEINLEKRCQLLQSELNGMLNDFEQITRNMLDFESERTHLENTIDTLKEKCEELEGQLSDKKIQWLGKENLSPEKSNTEHNEAMNIALLRKEFRKMVQEIREEHSKKMKAELEERRKIENALRQLKKDMIQNNHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NIA4</accession>
    <name>M7NIA4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SGTA homodimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_03443</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SGT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875530.1">
        <property type="nucleotide sequence ID" value="XM_007877339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NIA4"/>
    <dbReference type="STRING" id="1069680.M7NIA4"/>
    <dbReference type="GeneID" id="19897130"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03443"/>
    <dbReference type="eggNOG" id="KOG0553">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044224_1_1_1"/>
    <dbReference type="OMA" id="DMARNMM"/>
    <dbReference type="OrthoDB" id="2335338at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000207">
        <property type="entry name" value="Small glutamine-rich tetratricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047150">
        <property type="entry name" value="SGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032374">
        <property type="entry name" value="SGTA_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831:SF2">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16546">
        <property type="entry name" value="SGTA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="SGTA homodimerisation" evidence="6">
        <location>
            <begin position="9"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="107"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="175"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="226"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="340" mass="37912" checksum="BB052D0171B5FF1B" modified="2013-05-29" version="1">MTSNFNTKHQFIAFMIVDWLQSCLKEGIIPEEEKEGIEIATHCISETFSVYPCDNEQRKNLGINSQTLTNIFEQALQQTGSSSLLTTEFTASINTTSDINPNNKAKAEEFKSQGNNAMFRKDYSHAIFCYTEALKLFPKDVIYLSNRAAAYSESGDNISAIKDAKLALEINPDYGKAYSRLGHAYFSMGEYKEALNVYLKGLKVDPNSEVMKRGYELVKKNLTEHNDSAPIQEKNLKSEDISKTSNLNSSSETPRVGIPDFTSMMNNPAFMSVAQNLMSSGALNNLLNNPHVARLAQNIMSGEQTPNIQDIINDPEMRNIARNFMGSFNGGNARQFSDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NIB3</accession>
    <name>M7NIB3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyl transferase family 8 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_03138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875196.1">
        <property type="nucleotide sequence ID" value="XM_007877005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NIB3"/>
    <dbReference type="STRING" id="1069680.M7NIB3"/>
    <dbReference type="GeneID" id="19896825"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03138"/>
    <dbReference type="eggNOG" id="KOG1950">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049943_0_0_1"/>
    <dbReference type="OMA" id="WRRTDQT"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="34954" checksum="6F1701C33FA1720A" modified="2013-05-29" version="1">MTDTCSKRSWVTLLSDLGEKNGYLNGILTLNYTLIKVKTRYPLLVIYTSKCQATALSILEKSGIKTKYVEMLQPSITLNYGTDTKRFNECFNKLRVFELFEYERVVFIDSDMIFMKNADELFDIPLDRGFIACAHACVCNPRKKRHYPKEWVSSNCAYTAQQNLHSGSLISCSYGIKMLNSGLVVLNPNPEEFAIILDHVRNCEKYPLSMLNFAEQSLLSCLYEEKWMPLPYIYNALKTLRTVHEKLWNDDDVKILHYILDKPWHDENESLNSQDPTHAWWWTLEKERLEKETNSIIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJ44</accession>
    <name>M7NJ44_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_03114</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875170.1">
        <property type="nucleotide sequence ID" value="XM_007876979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJ44"/>
    <dbReference type="STRING" id="1069680.M7NJ44"/>
    <dbReference type="GeneID" id="19896801"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03114"/>
    <dbReference type="eggNOG" id="KOG0653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020695_4_0_1"/>
    <dbReference type="OMA" id="QRMRDHY"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044843">
        <property type="term" value="P:cell cycle G1/S phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20537">
        <property type="entry name" value="CYCLIN_CCNO-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20559">
        <property type="entry name" value="CYCLIN_ScCLN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000010">
        <property type="entry name" value="G1/S-specific cyclin Cln1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="95"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="190"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="194"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="342"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="368" mass="42157" checksum="28030DD2C91A3A79" modified="2013-05-29" version="1">MPVKSIIPDSCLRANIAKQRRPSLPLSPISGEGTGEFKKRKESCIKNTQSSMIQDDYREETIAYMKTMEKATLASPKMMDLQPELEWYMRPYLIDFILEVHSGFHLQPVTLYLTVNLIDRYTSKRVVFKKHYQLLGCAALWIAAKFEEPKDRVPTLKELSTMCCDSYREEMFVQMESHIIKTLDWMIGHPTAFTFLQMMTIYANFPENIVTLAQFFTELALFHRDLICLPSTVAEASLFLAQSILQPKKYYMISSSDTFACINTFHSHLNNISDVILKKYSHIGIKKIISDYLSSISSTRTSLQVNSPHTPSPHRHSRHSQFYLCINNHTSETIADQFGDIQKSETGLPTPPADDNECNHYADVSPMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NK02</accession>
    <name>M7NK02_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02732</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874759.1">
        <property type="nucleotide sequence ID" value="XM_007876568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NK02"/>
    <dbReference type="STRING" id="1069680.M7NK02"/>
    <dbReference type="GeneID" id="19896423"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02732"/>
    <dbReference type="eggNOG" id="KOG0590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_82_2_1"/>
    <dbReference type="OMA" id="EVCTEEY"/>
    <dbReference type="OrthoDB" id="2421129at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF51">
        <property type="entry name" value="PAS DOMAIN-CONTAINING SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="198"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="514" mass="58918" checksum="3454973F49F6ADC4" modified="2013-05-29" version="1">MEYTGDSSSVKCETNDVSLLTKKLSICRLGSFSTPVSRVPSARCCSDVSFKGSSLDFSSVSPVSTMNMHSSKRIFLNDEQSRRPIYRIGNYFKKSKNLSIISSRFFSKCLSSRNNLSVDVSTKKFLKHENERVSNEKEAHVSHSLLDLKHFFKSHHDHVQLNTQESLRQKKYSLFKLKFRKFEDSFKNKYSALSYRYKKYGKLVGSGTGGSVRLLSSCDGTVYAVKEFRKRAPYESSREYKKKVSAEFCVGAALHHPNIIQTLDFVSDGSRYYEIMEYAPYDMFSIVMSGKMTREEIYCCTKQILQAVDYIHSLGLAHRDLKLDNLVMNDNGIVKLIDFGSAIVFRYSSKNFVKASGIMGSDPYLAPEVCTEEYYNPQPADIWSIAIIFCCMILCRFPWKNPRVSDVSFREFSMGKTETENNEIEYLMSAPTAMIGDSPSPNVRGPWRLLRLLPRETRSTIQGMLEINSKCRWTMEQIMEQAWIKSVEMCYINSKNEVVKAKNHVHTSVLEKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NKX5</accession>
    <name>M7NKX5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal RNA-processing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02253</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874242.1">
        <property type="nucleotide sequence ID" value="XM_007876051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NKX5"/>
    <dbReference type="STRING" id="1069680.M7NKX5"/>
    <dbReference type="GeneID" id="19895946"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02253"/>
    <dbReference type="eggNOG" id="KOG3911">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022876_0_0_1"/>
    <dbReference type="OMA" id="AMWFSDR"/>
    <dbReference type="OrthoDB" id="2019504at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010301">
        <property type="entry name" value="RRP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026">
        <property type="entry name" value="NNP-1 PROTEIN NOVEL NUCLEAR PROTEIN 1 NOP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05997">
        <property type="entry name" value="Nop52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="30976" checksum="C5986342BD4E1166" modified="2013-05-29" version="1">MMAEKPLITHEYRQIIKKLSSNDKKTRDSVVELLPSLLSLRPLEYIELLKLWKGLYYCMWMCDRPLAQQKLANDFVNLIFKCPSNNSLLFLKAFWETICREWNLIDSLRLDKFYLLIRKNIEGGFRLCMSLNWSEKVVNNYVLLLEDIPLNPTNPKIPNSIRYHILDVYLDELDKVFPVKSKNQNFQIKVFLAPFLNLVKKSPDKYLKKRISETIFLDKRIELWNNKKDDYNFDNEILDVDDKNNEDAFVEEWYGFDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NL40</accession>
    <name>M7NL40_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02322</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874322.1">
        <property type="nucleotide sequence ID" value="XM_007876131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NL40"/>
    <dbReference type="STRING" id="1069680.M7NL40"/>
    <dbReference type="GeneID" id="19896015"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02322"/>
    <dbReference type="HOGENOM" id="CLU_373426_0_0_1"/>
    <dbReference type="OMA" id="TIMISKP"/>
    <dbReference type="OrthoDB" id="5302170at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051266">
        <property type="entry name" value="CLCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579:SF57">
        <property type="entry name" value="OS11G0687100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="27"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="174"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="573"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="627"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="573"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="643"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="744" mass="84244" checksum="559FE969AE654A0A" modified="2013-05-29" version="1">MSLRKHDLQRRQSEYSLRASYLKPVFCVVCYRPIDALSSPYDPGCGHIGHEDCFRQKVNCPKCLGPVNMITGLQVKKSENKLQRLFSNAKQKSIFFRNSTIPLEQNHMYKSTQNECLSRKISEIPSHPAIFGIDFEIYTDYDVVQKSEGEVIMYINVLSQYQDTIDLPCIYSLDVAVCLDMSESMAHGNKFNILKEIIFTLLYDLQSTDRMCILTTLSDDKNKIFALHTCDNLHKAAVQANLGERLKDMKGIHSCYSDDGISKALDILIKNKRNGRLGHIIVISDGCEVSVSNDKVNHISSQAKRHNIAIHSFGIGPCPDPTYLRHLTSLGAEGGCYIRVNEIRKVKNFLKLCAAGSCMASLSNVKINVTGLEGVGICDIRGDKNVYYDADSVYKHDNKLELIIGNLTPLEERCFFITLSIPSVSNFSDVDPFVVSTEALASELESIVKTFPANIASCKISYNHPCFSTSTILRLNTKYATIKRSDNLEESQETSQKNRNRTVLLALLRQYALQGIIHAHEMVNRGRVKAASSLINVALGKIEDAVIDEVWRPDEINELKDELRFQRSRIHSRTVSTTPRRTYTCMTPSKHERSTKIQPLRTPPKVSPTSVSKELWKCPTKIQDTFLDTRPTPHKSILKDHSTNTVSTLETPKSQRSLSLARTRSHITKTTTTIEYSANLSHLKEGQRSRRRSLDPLVLRESSSYSSIILPQTNSQIHHRKESWQADDEAKRIWRELKREMRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLH1</accession>
    <name>M7NLH1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_03489</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875579.1">
        <property type="nucleotide sequence ID" value="XM_007877388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLH1"/>
    <dbReference type="STRING" id="1069680.M7NLH1"/>
    <dbReference type="GeneID" id="19897176"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03489"/>
    <dbReference type="eggNOG" id="KOG1692">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066963_4_0_1"/>
    <dbReference type="OMA" id="QEKMMET"/>
    <dbReference type="OrthoDB" id="62956at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082268" description="GOLD domain-containing protein" evidence="10">
        <location>
            <begin position="23"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="32"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR08047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="202" mass="24369" checksum="E62D0C874C39D83F" modified="2013-05-29" version="1">MRFFYIKKILLVILPLFPLSLGYSIVLKYGDHECFYEKMKKNEKLTISYQASSNEYEEEMLFVTFDVWDPEEKTLKTENSLFYDEFSINADIEGKYKYCFSNKVHHNLDIELFFNVHHIKDTHIAEDASDFNREVAFLNEVLMDIRDEQEYLKAREKVHRSIAENTNSRVQNWNIFQIIILISLVLFQVYFLRKFFEVKRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLY5</accession>
    <name>M7NLY5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_03381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875465.1">
        <property type="nucleotide sequence ID" value="XM_007877274.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLY5"/>
    <dbReference type="STRING" id="1069680.M7NLY5"/>
    <dbReference type="GeneID" id="19897068"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03381"/>
    <dbReference type="eggNOG" id="KOG2401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_618365_0_0_1"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052772">
        <property type="entry name" value="Endo/PolyKinase_Domain-Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535:SF1">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="23"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Smr" evidence="1">
        <location>
            <begin position="347"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="51653" checksum="97FADBAD2C910E36" modified="2013-05-29" version="1">MKYHKNCLFKNESNPSISQRKTSNNDTLSFLQMIFPQQDTDVLKHIQEEYGNSLEKVINENLDIMDDDKNYDSLNDSFSKDSLEIPKTKRKKSKKIKNIPLDEWYKRNEAQESTVDFRMKPSLKWNDIIPNIEWLADIFNIPKKQAASIYHQSSVSLSKSVYNLLSSDYMIQRINESLVMLQHDYKSNLKQLKKQFPSLEEHMYSRILLSVENDLPKAISVVKTIQQSPIYIKDQNQTHHFNTSSSERHNHINDDYKSKLDNSSDDMIHTDYNLEECKANLSTFIFNRNHAFKEAAKAYRKAKTQGLYRDIVTYYSKKAQEYNSKVKLWNMRAKMCMIQNSLPSYLIDLHGLTIAEAIPLVKKAVAQWWSHEQKLQTDIPTPLEIITGAGLHSKNKLPKIKPSILQLLNKEGWLIEEKPGKIIVQSFQTNEFHTTPKQLISHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7NM61</accession>
    <name>M7NM61_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial</fullName>
            <ecNumber evidence="4">2.1.1.201</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ubiquinone biosynthesis methyltransferase COQ5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">COQ5</name>
        <name evidence="5" type="ORF">PNEG_03394</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-methionine = a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="EC" id="2.1.1.201"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.201" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875479.1">
        <property type="nucleotide sequence ID" value="XM_007877288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NM61"/>
    <dbReference type="STRING" id="1069680.M7NM61"/>
    <dbReference type="GeneID" id="19897081"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03394"/>
    <dbReference type="eggNOG" id="KOG1540">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_0_1_1"/>
    <dbReference type="OMA" id="MNDVMSM"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008425">
        <property type="term" value="F:2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="161"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="293" mass="33651" checksum="FFDEDC912865B857" modified="2013-05-29" version="1">MLSLRRLLVYKPSFIIKSQYHFSPRILKDQILENGTHFGFKKVPESQKENLVHNVFTSIASSYDLMNDIMSLGIHRLWKDEFVQRLDPGSLNEEPMHLLDVAGGTGDIAFRLLDYATDVHFDTQTRVKCVDINPDMIEIGKKRLENSRYRYSKRIDFFIQNAENLTDIASSSINIYTIAFGIRNCTRIMDVLKEAYRVLKPGGVFSCLEFSRISLKPLESLYNYYLFNIIPIMGEVVVGNRDSYQYLAESIVKHPDQKTFSKMMESAGFKLIGNGYHNLSFGIVAIHTGIKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMD5</accession>
    <name>M7NMD5_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08271.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613285.1">
        <property type="nucleotide sequence ID" value="XM_019757757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMD5"/>
    <dbReference type="STRING" id="1069680.M7NMD5"/>
    <dbReference type="GeneID" id="19897123"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03436"/>
    <dbReference type="HOGENOM" id="CLU_022141_0_0_1"/>
    <dbReference type="OrthoDB" id="5464814at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006963422" evidence="1">
        <location>
            <begin position="18"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08271.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="543" mass="62526" checksum="5600470E19DBBA54" modified="2016-03-16" version="2">MKIILFFLFTFITYVLSGTFGPLGFTELMPPYEPPSIELHFTDNLISGTYSFDDLLIFLTARNDHSCLQHLSNTCEELTKVYGDLSRIGNAVKSICEHQHEACQKLPEVKKELCNLDKVTYEKLKESSFTEEDQCYTTYTKCRFRSRGCFYEYMEQCRKLLYICRYIYSEYELHAYFINLLGNDFSSETFREKLKVTCRDLFDTSDLFVQLCFNPDSLLSDLSITDVFQKAGKLSFFFYSQWSTGALLNAQGLDGGLFLPRTDPSVNPAYFMGYLLGQHGFTSFVSDCVKISQKCLGLGFFPQSAYFCNAESNTHWDTTCKKTEVALLEQHVPNLKKELEYRLSDQQYPEGIFWSGINVNLCTKFLRPCSYLGKLDSTLNSLCDYLRGHCAYGLEIGSSLNIFEYQFRKANLREDSIHNLDLCQQALPQICTSILNKTVDFLAFCLKPSHTCFALMSLYLHRCDELKKGMTEIDLSEKECLIKLQKADTYGSMCPQSEEYLKFLTTCYTNYPQNQYLKNLAASRLKDLTSQEIESEKLDDDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMI5</accession>
    <name>M7NMI5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mRNA 3'-end-processing protein RNA14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_03171</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">Nucleus and/or cytoplasm.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875234.1">
        <property type="nucleotide sequence ID" value="XM_007877043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMI5"/>
    <dbReference type="STRING" id="1069680.M7NMI5"/>
    <dbReference type="GeneID" id="19896858"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03171"/>
    <dbReference type="eggNOG" id="KOG1914">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007630_0_1_1"/>
    <dbReference type="OMA" id="PKRQYFK"/>
    <dbReference type="OrthoDB" id="26282at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045243">
        <property type="entry name" value="Rna14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980:SF0">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980">
        <property type="entry name" value="RNA CLEAVAGE STIMULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Suppressor of forked" evidence="5">
        <location>
            <begin position="90"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU369035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="752" mass="87993" checksum="507D0E5C5D43650B" modified="2013-05-29" version="1">MEDNISEKKEKEATLMNSEELISEDSLLNEKKRMNSSNFSERYMNHENSEKSEKKEKREDFMNNKITSESDSLQNISSLKTNKRKRLSQDRVGQLEDLIAMDDKDASSWLKLIKEHQDKNKIEEARNVYERFLKVFPTAAQQWIDYADMELTNNEFIRVETIFSRCLRSVLSVDLWKFYLDYIRRINNVSTGGAQARSVISQAYEFVLAHVGIDKDCGSIWSDYINFVKTAEKNSMWEEQQKIDHIRRIYHRAICIPIANIETLWREYDAFENNFNRSTARKFLSEKSSSYMMARTAWKDMASITAGFRATNIPKVPVWTEKDVEEVEQWKRWIEWEMSDPLDLKLKPAIVTRVKYAYKQAMINLRFFPEIWFSAVEYWLSLNEEKEAVEIMKNGIIANPTSYLLHFQYADFLEQNKRFSEMRTIYETLIENLSKEFKKISCYMENKISEVSKYLEYVTPQDPVEEGEIQKLTPKKEIQNIQKQGEEELNKLTKNISIVWSVFMRAVRRTEGIKAARQVFGKARKVPNQAYHIYVASALMEYHCSKDSTIASKIFDLGLKSFGNDPDFVLHYLTFLININDDTNARALYEKTITHLDPQIVKQLHEKLYTYESMFGDLSTTIKLQSRIAELYPDDSSILRFSRRFKFYNLNAILEKDLGVVFKSSIISEPTEIHNNDVFQLNLDIRKKNLTTSLLTTNDKLLSLPESILYFLSILPPASSYTGATFKIDELIKLISETEVPTSIKRKLTASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMM3</accession>
    <name>M7NMM3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS17c</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_03216</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875279.1">
        <property type="nucleotide sequence ID" value="XM_007877088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMM3"/>
    <dbReference type="STRING" id="1069680.M7NMM3"/>
    <dbReference type="GeneID" id="19896903"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03216"/>
    <dbReference type="eggNOG" id="KOG1740">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073626_1_2_1"/>
    <dbReference type="OMA" id="HPMYGKF"/>
    <dbReference type="OrthoDB" id="274752at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_uS17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_uS17_bact/chlr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004123">
        <property type="entry name" value="PRK05610.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="97" mass="10975" checksum="BA17BFB66CB3D203" modified="2013-05-29" version="1">MRQNFKGIVVSSGLMKKTVKVKVIRKILHPKVHKLITLHKNYLAHDEGSVCKNGDLVRIEACRPLSARKRFSVAEILQKAKISQDTIDQANDLTLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMQ2</accession>
    <name>M7NMQ2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Plasma membrane ATPase</fullName>
            <ecNumber evidence="17">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PNEG_01721</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:20853"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Cell membrane</location>
            <topology evidence="2 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="17"/>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873685.1">
        <property type="nucleotide sequence ID" value="XM_007875494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMQ2"/>
    <dbReference type="STRING" id="1069680.M7NMQ2"/>
    <dbReference type="GeneID" id="19895415"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01721"/>
    <dbReference type="eggNOG" id="KOG0205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_6_0_1"/>
    <dbReference type="OMA" id="VIEFHPF"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02076">
        <property type="entry name" value="P-type_ATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000011">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000005">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000008">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 17" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="14 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 17" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="327"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="689"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="719"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="759"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="826"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="861"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="18">
        <location>
            <begin position="68"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMR09963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="927" mass="101611" checksum="C15906AFC35EE204" modified="2013-05-29" version="1">MSEEGKALIHETVYYKHTNTFEINNSAKDLEKGDEEECLLEDEDNDIDALIDDLESQDGDQEDNIEDTEFQSQRQVPEELLATDTRIGLTSQEVINRRKKYGLNKMKEEKENMIIKFLMYFVGPIQFVMEAAAILAAGLQDWVDFGVICALLLLNAFVGFIQEFQAGSIVDELKKTLALKATVLRDGRLIDIEAEEVVPGDILQLEEGSIVPADGRIVTEEAYLQVDQSSITGESLAVDKHKGDSIYSSSVVKRGETFMVVTATGDGTFVGHAASLVNKASCGTGHFTDVLNRIGTILLVLVVFTLFIVYISAFYRSSTTITILKYTLAITIIGVPVGLPAVVTTTMAVGAAYLAKKKAIVQKLSAIESLAGVEILCSDKTGTLTKNNLSLSEPYTVEGISCDELMLTACLAASRKKKGLDAIDKAFLKALRNYPAVRSALSRYKVIEFHPFDPVSKKVTAIVESPSGERIVCVKGAPLFVLRTVEEDQPVPEDIQNAYKDKVAEFASRGYRSLGIARRAGNSNWEILGIMPCSDPPRCDTARTISEAIRLGLRIKMLTGDAVGIAKETARQLGMGTNVYNAERLGLGGGGDMPGSEVYDFVEAADGFAEVFPQHKYNVVEILQQRGYLVAMTGDGVNDAPSLKKADTGIAVEGASDAARSAADIVFLAPGLSAIIDALKTSRQIFHRMYAYVVYRIALSLHLEIFLGLWIVIFNHLMILELVVFIAIFADIATLAIAYDNAPYSLLPTKWNLPKLWGISLLLGAALAIGSWIALTTIYINDNAFGIVQGYGNVDAVMFLEISLTENWLIFITRANGPFWSSLPSWQLFGAVFLVDVIATIFCIFGWFTGTKEHGLERTSIITVVRVWLFSLGVFCIMAGIYYLLSDSVAFDNIMHGKSVKKNSKQRSLEDFVVALQRMSTKHEKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMX0</accession>
    <name>M7NMX0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_03053</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynactin 150 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875109.1">
        <property type="nucleotide sequence ID" value="XM_007876918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMX0"/>
    <dbReference type="STRING" id="1069680.M7NMX0"/>
    <dbReference type="GeneID" id="19896740"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03053"/>
    <dbReference type="eggNOG" id="KOG0971">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002523_2_0_1"/>
    <dbReference type="OMA" id="LIMECEQ"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000743">
        <property type="term" value="P:nuclear migration involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022157">
        <property type="entry name" value="Dynactin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF85">
        <property type="entry name" value="TUBULIN-FOLDING COFACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12455">
        <property type="entry name" value="Dynactin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="10">
        <location>
            <begin position="21"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="506"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="910"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR08577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1213" mass="141959" checksum="E9A64F110520626D" modified="2013-05-29" version="1">MISLNDRVFVGKTLGTVRFIGRTDFSTGEWVGVELDMPTGKNNGSVKGKQYFECKENYGVFVRISAVKKVELKEEELLEDVNDESGRSSSLSPSKRSVFQSFRSMGSVSRIPYIQSSVGQQKILNTKASFDESISPCKGKKSRYMCEKSPEVLRMESSVCKSPVRSKIFQEKEENDIQSEKEERIECEKGVFGGRLCFEESKVSFEDSYGKFESNDTVLIDELKKELKVLEKKRIEDRNKLKLLEEQLQEKESLEKAKNRLQNKILSLQNEIRDLKLSLRNMENEKAEFEMKFIEVSEILEVTTLDKEIAEQRADILESELNALKNEIQNSVDKRSEDISKKEQDELDEKDLEEQNKVLKEALIKLHTMTNNQEVELKNTIKHHQLEIESLKKYKVQYESLKEKLQETENLVDDLRQQVDISLTAEEMLEELTEKNLYLKEKIEQMNITIQDLESLKELNDELEENHLENERQMREELEYKDSILIENMNKITQLKEVNSEYELVILKFRELVGNLQRDLENLRLENQNAKMESTELSIRSKEIMDLNLKLKSSSVKSQATKIEYELKRLEGLEAVEKFEITQFFLPDSYSSENSSIMVYFKCRRIAMKSVLLHDIIKEKILYNISINNILEIDFLLEAMEINKNLVFLSTIARRFTYFMNICTLLDFGEISSSFSKLDILENILDTEINILKKNEYYEKKFLGVLEEAVLLFNSLSDVYIKPYDGESISKIESELFFSLSYIENFLKEESILRNLLESDYMKQIMGGNTTSILVLIEKLETFSSQAEKIIIIINKFFKIMDSMKENSLSLKETIVSEFFDLRNMANFLYDAMKKNLVYFNGLLNKYLEGIGVCFSEKDVLLDLNLDNISEKIASFTFILLKLEKNINYSENTFQISQNIAPWILHSNEIKSILQKNNDTEKKLNILQDRINQYIIDIRLKDKVIEEVNIKTELLNKRTADLKRHSETIKILEKSLNDAVLKEKQSNETIKTLNEKTKSMEKIINNFQTTKNVSDINSLEESIINSRIFQNRIQEFSNEIELFNNSISYLKEEIKLLSTNKMILDNSWLSEPLFKTNDEISKKREKRTSEIRFLLKSLRMFSSKTSVIKLSFKKQNGWMSETKRPRYKHFKQQEEYVSLCAKRDSLVSINDFTFRRPVCNSTTTPLVHCTLQMPSYGLNNIQQDDLLLQNIEINHFKELERIHYSILKPLRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMX7</accession>
    <name>M7NMX7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">A-kinase anchor protein 7-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875409.1">
        <property type="nucleotide sequence ID" value="XM_007877218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMX7"/>
    <dbReference type="STRING" id="1069680.M7NMX7"/>
    <dbReference type="GeneID" id="19897300"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03613"/>
    <dbReference type="eggNOG" id="KOG2814">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1168302_0_0_1"/>
    <dbReference type="OMA" id="HLTIGMI"/>
    <dbReference type="OrthoDB" id="277832at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009210">
        <property type="entry name" value="ASCC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360:SF1">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027019">
        <property type="entry name" value="Euk_LigT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A-kinase anchor protein 7-like phosphoesterase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="238" mass="27547" checksum="117F83E45DB907B2" modified="2013-05-29" version="1" fragment="single">YLRKAYSAIHFDKQIEEKSLNTKKFRENFKKRTGYPTHFLALPLRSKSLEKSIAEIKKLLINEVPLSIFRDYLLAHLTICTLRLPSDKEIESSLSLLYSLKDEVSKFSNNKKIHIRFRGLGTFPEEPTNCRVVYLKPSLKESSPALFPLCEFLMKKFVDAKFSDSNLLVLHSTILNTRYEKSYAKEKKSINASFLMEKFPSHFLFGDVTVDKICIFKMGARKTQNGLIYESIGEVNML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN40</accession>
    <name>M7NN40_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_03022</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875073.1">
        <property type="nucleotide sequence ID" value="XM_007876882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN40"/>
    <dbReference type="STRING" id="1069680.M7NN40"/>
    <dbReference type="GeneID" id="19896709"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03022"/>
    <dbReference type="eggNOG" id="KOG0578">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_26_2_1"/>
    <dbReference type="OMA" id="NFTHRVH"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13279">
        <property type="entry name" value="PH_Cla4_Ste20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000139">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000705">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="11">
        <location>
            <begin position="48"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="13">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="450"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR08541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="731" mass="81974" checksum="4AD153AC107E7463" modified="2013-05-29" version="1">MAHNLSSQYFVNPGPAPAPPLKIPSYSSSNIYAGRCFDVSQTYKDSKGILKAGWANVKEDSIKSWIWTKKYLVLREKVLYILKNESSTSPGLSIPLREITNVSRIELKDYCFEIVRDPGIGMCIRNGSGTKKSYFISLKSDNDLYSWMDEIYSRCPLMMVSNPTNFTHKVHVGFDPKSGGFTGLPEEWTRLLTASAITKEDYAKNPEAVIEVLQFYSDTQLREKDEFGEPSMLGPDPCDVENLDVKSFEQNKMTLEKYHANNGFIYQYPVSSASKSIVPLRERLKKMDIKGSEKMVPYRVPPVLPQNLPTRLNIDLGSSSHENDSLLSSGSLNVEKGFGVTVKKRQNALPDTLKHKQSQNNLAFISQAPTQPLPKIPVSSKNIPDISTAFSETSVKHPCLNKKLPSSLSNLRTAKQDLPSEDKKVNDLTENQVMERLRNVVSTDDPNILYTKIKKVGQGASGSVYVAKVNLDIKSGNCELKTGLKVAIKQMDIAHQPRRELIVNEILVMKESHHPNIVNFLDAYLAKNSELWVIMEYMEGGALTDIIDNNTLTEDQIAAISLETCKGLQHLHQQKIIHRDIKSDNVLLDFHGRVKITDFGFCAKLTEQKNKRATMVGTPYWMAPEVVKQKEYGPKVDIWSLGIMAIEMIETEPPYLNEEPLKALYLIATNGTPTLKKPDKLSKELKSFLAVCLCVDVKSRATAEELLEHEFLKKSCSLSNLSSLLAFKSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNC4</accession>
    <name>M7NNC4_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873405.1">
        <property type="nucleotide sequence ID" value="XM_007875214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNC4"/>
    <dbReference type="STRING" id="1069680.M7NNC4"/>
    <dbReference type="GeneID" id="19895162"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01466"/>
    <dbReference type="HOGENOM" id="CLU_2185086_0_0_1"/>
    <dbReference type="OMA" id="KFLIWSE"/>
    <dbReference type="OrthoDB" id="5344687at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42089">
        <property type="entry name" value="YALI0F09427P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42089:SF1">
        <property type="entry name" value="YALI0F09427P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="109" mass="12627" checksum="718978236AB969E3" modified="2013-05-29" version="1">MAPKISLIISPSLFIPEPITLPYEYCSLTLETPKPLEEVFECISDIKTSSLNHYEHLNKKFLIWSERLKQWEASAEARYLYEIRKIAPGYLDTNERLLQPTLTKPSSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNE6</accession>
    <name>M7NNE6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA repair protein RAD2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_03117</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the XPG/RAD2 endonuclease family. GEN subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875173.1">
        <property type="nucleotide sequence ID" value="XM_007876982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNE6"/>
    <dbReference type="STRING" id="1069680.M7NNE6"/>
    <dbReference type="GeneID" id="19896804"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03117"/>
    <dbReference type="eggNOG" id="KOG2520">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003018_0_0_1"/>
    <dbReference type="OMA" id="PNSMDFS"/>
    <dbReference type="OrthoDB" id="31113at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048256">
        <property type="term" value="F:flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09904">
        <property type="entry name" value="H3TH_XPG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09868">
        <property type="entry name" value="PIN_XPG_RAD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000030">
        <property type="entry name" value="Flap endonuclease GEN-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001044">
        <property type="entry name" value="XPG/Rad2_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF7">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00066">
        <property type="entry name" value="XRODRMPGMNTG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="13">
        <location>
            <begin position="737"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR08641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1093" mass="127658" checksum="17D21BA59141C436" modified="2013-05-29" version="1">MGVTKLWTILEEASRFVKLESLSGKILAVDASIWMYQFLKGFRDKDGNFIKNGHIIGFFRRICKLLFYGIKPIFVFDGNISVLKENIIKKRTEKRLKYDENSEKLAEKIFLLQMKKTVQKDIQGKKQNNKLKKSPYFENMENLSKDIEIIQKNGNRDIYNLPSLNVSFEQIQQSDDFRMTSQGNIQESIHNFTNEDLNSLDFSKIDYDSDFFKSLLPADQYNILNIARLRSRLRMGLRADELMTMFSNSMEFSKFQITKVKERNDLTQRLLNFNEINKAGALRVVGEPNREYLLVKDEDTKTGWVLNFDLKNQKNLIVINDEDHDSTHEDEEFEDIPLYDINSSPMENIGNFLIDDSEKEIFKKTDDYYKINCHSYNIKNKPLFLELDDFDINLECNEHVEKMKRDEKKIEHSKNNQFNDELKLNNIRYQSTPNSEENIAKSRRLKSNNKLSLPQFDIFSKSNENSENHLKTKVLVPKNEISKLNQNFEPLSNLEKSGHILNLSKPSFRYNKISSQNLLNNTIFLEENIEEPQEVYKSRNKKESFILFTDISTLKENSVFLNNFKAHNYFVDKNISHEDNSKKALDIKINLESIKNISAKNTSIKETDSKSDKFMSLSIPIVDNCSEIELVANNYSNSSNKNQEKSKIGADSIHNISDIDEYDDYNLDLENDTLTNYLLEENEEHNRFFSELNKTNDSTETNIEKDLDLLMNRYRKTKKNADSVTQIMIEECQNLLKLFGIPYIIAPMEAEAQCAELLKLGLVDGIITDDSDVFLFGGTKVYRNMFNHSKYVELYLLSDLEREFNLGRKNLIRLAHLLGSDYTEGIPKIGPVTALEILSDFPNSDSLNEFKEWYDRVKDSKETQDDETSKFRYRFKKNIYNILLPKDFPNPLVDKAYLEPEVDSNFKDFEWGIPDLDNLRDFLVSTVGWSLQKINEMIIPVIRNMNFKRMNMVQTVLTDYWFIGSNIFISKPKISNKATRFTKALNNLKRSGKTTYNQHKILNSESTLNENIANASKNFLEFGNSLINVKNKDFDIINKNINYTFDNTKSFSDNASIMNTQKYKKNIFLNLSRDLNEKKDIFKNIKRKQQDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNF2</accession>
    <name>M7NNF2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Elongation factor G, mitochondrial</fullName>
            <shortName evidence="8">EF-Gmt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Elongation factor G 1, mitochondrial</fullName>
            <shortName evidence="8">mEF-G 1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Elongation factor G1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MEF1</name>
        <name evidence="10" type="ORF">PNEG_03124</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875183.1">
        <property type="nucleotide sequence ID" value="XM_007876992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNF2"/>
    <dbReference type="STRING" id="1069680.M7NNF2"/>
    <dbReference type="GeneID" id="19896811"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03124"/>
    <dbReference type="eggNOG" id="KOG0465">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_4_1_1"/>
    <dbReference type="OMA" id="GQFAKVQ"/>
    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04091">
        <property type="entry name" value="mtEFG1_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000003">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000022">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000514">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047872">
        <property type="entry name" value="EFG_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009381">
        <property type="entry name" value="PRK12740.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636:SF2">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="63"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="72"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="147"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="201"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="765" mass="86688" checksum="233B8ACE4754A131" modified="2013-05-29" version="1">MFCQLFRSPLFSILLKRSENNHLYFGFQLKYLSSVVNTFSNSTQYVFKKKNENIMENNMERLKWQRNVGISAHIDSGKTTFTERVLYYTGKIKSIHEVRGKDNIGAKMDFMDLEREKGITIQSAATYCDWVKQDEGKEQKYSINIIDTPGHIDFTIEVERALRVLDGAVLVLCSVSGVQSQTITVDKQMKRYNIPRISFINKMDRVGSNPWKVIEQIRNKLKISSATIHVPIFDNSTFVGVVDIIKMKAIYNEGHRGINVVEKDEIPNGLLHLVNEKRTELIETLADIDNEIAELFLNEKIPTERQLYNAIRRTTLEKKFTPVLMGSALQDIAIQPVLDAICDFLPTPAEVENTALDISNNEECVKLIPSDSEKFVGLAFKLEESKYGQLTYFRVYQGTLKKGDYITNMRTRKKIRIPRLVKIHSNEMEDIEIIGSGEICAIFGVDCVSGDTFADDSLMYSMTSMFIPEPVVSLSLKQKGKESASFSRALARFQKEDPTFKVKLDTESKETIISGMGELHLDIYVERMKREYNVECTVGKPQVAYRETITSRSTFNYTHKKQTGGAGQFGKVEGYIEPILSDNSSNLDVEFLSRVTCGNIPTNFILACEKGFRDALKNGLLIGYPIKGCRMVLEDGATHSVDSSELSFYIATLNAFKQAYNKANPIILEPVMKLAVTAENEFSNAIISGLNKKKAVILNTDIRSDDFTVEAEIPLNNMFGYSTDLRANTQGKGEFTAEYLKHSVVPDYIQKELIIKYQKQAQRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNU1</accession>
    <name>M7NNU1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02708</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874733.1">
        <property type="nucleotide sequence ID" value="XM_007876542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNU1"/>
    <dbReference type="STRING" id="1069680.M7NNU1"/>
    <dbReference type="GeneID" id="19896399"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02708"/>
    <dbReference type="eggNOG" id="KOG2890">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1180637_0_0_1"/>
    <dbReference type="OMA" id="WDEAQIN"/>
    <dbReference type="OrthoDB" id="73612at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013861">
        <property type="entry name" value="TMEM115/Pdh1/Rbl19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377">
        <property type="entry name" value="PLACENTAL PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="196"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="235" mass="27324" checksum="F5E568717CBDF598" modified="2013-05-29" version="1">MIEQKASLLIKSIYGGYALYAGFLVALKQLIPEHVISFFKGIIRIRIKYTPALYIFIMPFIGLLVRDESLGILSWLGFLSSWIYLRFFKWNTPNLLSHLTFDLRGDTSETFAFSYFFPEPIHLLINTVSKKIHNFLVSTRIFSYSNETQTQQTEKLLNNFQQKQDFFLYSNTPRFEAERRKALALKTLEERLGSLTNSKPASQLSMTELSVSPKESFDQFSTINNENKNKNKSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNU9</accession>
    <name>M7NNU9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01624</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873582.1">
        <property type="nucleotide sequence ID" value="XM_007875391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNU9"/>
    <dbReference type="STRING" id="1069680.M7NNU9"/>
    <dbReference type="GeneID" id="19895318"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01624"/>
    <dbReference type="eggNOG" id="KOG3752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030894_0_2_1"/>
    <dbReference type="OMA" id="GWAAVIQ"/>
    <dbReference type="OrthoDB" id="407198at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09280">
        <property type="entry name" value="RNase_HI_eukaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017067">
        <property type="entry name" value="RNase_H1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036852">
        <property type="entry name" value="Ribonuclease_H1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="8">
        <location>
            <begin position="64"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="218" mass="25398" checksum="05E9B35E1822EB70" modified="2013-05-29" version="1">MNIFQRILKKNISLYNGLLNNYKRNSFSDMKNDKDRSNFVLKYIKKDINISSSICNFEQKKISKNNYIEIYTDGSSHYYEGGKVITGIGVYFGDNDKRKVNISERIFDKKQTSQRAEIIAVIRAIESVSDDEDIRINTDSKYTINSLTIWHKKWEKNNWKKINTKSVKNKDLLEKAVELIKKRSGCTELKYVSSHSNIHGNKQADYLANMSISFQKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNY6</accession>
    <name>M7NNY6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T-complex protein 1 subunit zeta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-zeta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02979</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875026.1">
        <property type="nucleotide sequence ID" value="XM_007876835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNY6"/>
    <dbReference type="STRING" id="1069680.M7NNY6"/>
    <dbReference type="GeneID" id="19896666"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02979"/>
    <dbReference type="eggNOG" id="KOG0359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_3_1_1"/>
    <dbReference type="OMA" id="LHPRIMT"/>
    <dbReference type="OrthoDB" id="10052040at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03342">
        <property type="entry name" value="TCP1_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000038">
        <property type="entry name" value="Chaperonin containing TCP1 subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000058">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000004">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012722">
        <property type="entry name" value="Chap_CCT_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02347">
        <property type="entry name" value="chap_CCT_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR08811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="534" mass="59245" checksum="3A703F6DB636C1AD" modified="2013-05-29" version="1">MITFLNPKAESLRREQALQVNMAAAQGLQNVLKSNLGPKGTIKMLVDGAGNIKLTKDGKVLLTEMQIQNPTASIIARAAVAQDEITGDGTTSICLLVGELLKQADVYIQEGLHPKVISEGFDLSLKEALKFLDEFKIDKEMDRSTLLLVARSSLSTKLHPLLVESLYPSIVDAVLSIQRENEPIDLHMIEIMKMQHRTSTDTQLIKGLLLDHGTRHPDMIKKVENAFVLILNVSLEYEKTEINSGFFYSSAEQRERLVESERRFVDNKLRKIVELKKQVCGNDLKKGFVVINQKGIDPLSLDVLVKNGIFALRRAKRRNMERLQLICGGIAQNSVDDLTPDILGWAGLVYEQTLGEEKYTFVEEVKDPKSVTILIRGPNAHTISQIQDAIRDGLRSVKNAIEDRCLVPGAGAFQVACSVHLQKNFIHNVKGKTKLGVQAFSEALLVVPKTLSANSGFDTQDTIVALKDESHQGHIVGVDLKTGEPFDPISEGVYDNYRVIRHMLHSSCVITTNLLNVDEILRAGRSSLKETSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP58</accession>
    <name>M7NP58_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal protein/NADH dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02674</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874697.1">
        <property type="nucleotide sequence ID" value="XM_007876506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP58"/>
    <dbReference type="STRING" id="1069680.M7NP58"/>
    <dbReference type="GeneID" id="19896365"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02674"/>
    <dbReference type="eggNOG" id="ENOG502S1AY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141769_0_0_1"/>
    <dbReference type="OrthoDB" id="1696305at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040049">
        <property type="entry name" value="Ribosomal_mS25/mL61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="5">
        <location>
            <begin position="38"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="129" mass="14908" checksum="A1E1FF6492B58975" modified="2013-05-29" version="1">MAKRHTKAAEKLARILMGPGAFKLPSDIHGLTLFMAFKNKDGHMGPRKFWKDYLPSIQFHNPYLHIQVCRSHKEKEAKLKIHQKSGDIELDMKHKHALDICREFIEKTKAVAVGKEEMNEFIEKSNLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPK2</accession>
    <name>M7NPK2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCT-theta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_02804</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874837.1">
        <property type="nucleotide sequence ID" value="XM_007876646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPK2"/>
    <dbReference type="STRING" id="1069680.M7NPK2"/>
    <dbReference type="GeneID" id="19896493"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02804"/>
    <dbReference type="eggNOG" id="KOG0362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_4_2_1"/>
    <dbReference type="OMA" id="WGLKYAV"/>
    <dbReference type="OrthoDB" id="1748577at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03341">
        <property type="entry name" value="TCP1_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000008">
        <property type="entry name" value="T-complex protein 1 subunit theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012721">
        <property type="entry name" value="Chap_CCT_theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02346">
        <property type="entry name" value="chap_CCT_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR09031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="546" mass="59759" checksum="FD76FC918267E755" modified="2013-05-29" version="1">MSLKMPKASGPALFKEGYRTQQGVEDVVIRNIHAISELSEIVRTSYGPNGYNKIILNHLAKMLVSSDASTILEELDIVHPAAKVVVMASKQQDLEMGDATNFVLIFAGELLKHAEALIRMGLHPSEIEEGYEMARDFALKTLEELSVDKVEDIKSSDEILKAIKSSISSKQFGYEKLLGSLVAEATLLVLPKNPLHFNVDCIRVVKILGGCLDESRVVKGMVFPRDPEGIVRKALKAKVGVFSCPLDISQTETKGTVLLKNAKEMLEFSKGEEVLLESMVKELFDCGIRVIVTGGGIGDLVLHYLNKYNLLVIKVLSKFDLQRLCRVVGATPLARLGAPMPEEMGFVDVVETIEIGGDRVTVFRQENEITKTATIVLRGATQNYLDDVERAIDDGVNLVKAIVKDPRLVAGAGATEMELSKRIFSYSEEVSGIFQYSIKKFAEAFEVIPRTLAENAGLDSTEVLGKLYAFHHADNNCTIGVDIEGNNDLPFDAKLAGIFDVLSVKSWACKLATEAALTILRVDQIIMSKPAGGPKPPGPNPNWDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPQ2</accession>
    <name>M7NPQ2_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_02567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874581.1">
        <property type="nucleotide sequence ID" value="XM_007876390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPQ2"/>
    <dbReference type="GeneID" id="19896259"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02567"/>
    <dbReference type="eggNOG" id="ENOG502R7C0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1019840_0_0_1"/>
    <dbReference type="OMA" id="WISASEY"/>
    <dbReference type="OrthoDB" id="5391496at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR09232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="273" mass="31281" checksum="D4A05115003A1064" modified="2013-05-29" version="1">MNFPIKLLFPTAKESYISQNDINFSSPLYIQVPYVSVLISIVLGRERLRWMSERLNFNEKKEKSVLILCGYTKETFLKEILHVQDIQHFSTSNSETSIWSDDSFWTMDATGAWISASEYIDLIYVPSLRGLRAILSVYHYSSSLNRLAIWSFLKIHEASGEFSAQGLSRTIALAIEACRNENIIFCDSISIKSLIQLLNSSTKVSGISVCSAIRQITVETVMERWISAFWEIVSLNEQGIGYGIWKYRGEHWKVCWKDSGNGEISDIEYIRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPQ5</accession>
    <name>M7NPQ5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00839</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872748.1">
        <property type="nucleotide sequence ID" value="XM_007874557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPQ5"/>
    <dbReference type="STRING" id="1069680.M7NPQ5"/>
    <dbReference type="GeneID" id="19894537"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00839"/>
    <dbReference type="eggNOG" id="KOG1779">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130128_3_0_1"/>
    <dbReference type="OMA" id="CASILCQ"/>
    <dbReference type="OrthoDB" id="5567124at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.100:FF:000001">
        <property type="entry name" value="40S ribosomal protein S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00371">
        <property type="entry name" value="Ribosomal_eS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_eS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_eS27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11594">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01168">
        <property type="entry name" value="RIBOSOMAL_S27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="83" mass="9137" checksum="0C90F1E6B58DCA07" modified="2013-05-29" version="1">MALAVDLLNPVPEAEARKHKLKRLIQRPNSFFMDVKCPGCFNITTIFSHAQTVVICGSCASVLSQPTGGKARLMEGCSFRRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPU9</accession>
    <name>M7NPU9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Outer kinetochore protein DAD2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PNEG_02479</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874488.1">
        <property type="nucleotide sequence ID" value="XM_007876297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPU9"/>
    <dbReference type="STRING" id="1069680.M7NPU9"/>
    <dbReference type="GeneID" id="19896172"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02479"/>
    <dbReference type="eggNOG" id="ENOG502SG7I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138063_5_0_1"/>
    <dbReference type="OMA" id="QAINMAS"/>
    <dbReference type="OrthoDB" id="3230169at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013963">
        <property type="entry name" value="DASH_Dad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08654">
        <property type="entry name" value="DASH_Dad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMR09136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="118" mass="13252" checksum="FC16EBE21564E7B0" modified="2013-05-29" version="1">MSGNSSLSYRRQASSSFVPAHLQPNSALAAKIQEKKQEYENLSQLRDFSGKLVTQMEQLEKKMEILVGGTEVVASVLENWQNVFRTINISSERLQKKTVSNKNEGLDLPETLVRIPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPZ4</accession>
    <name>M7NPZ4_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pantothenate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02282</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874276.1">
        <property type="nucleotide sequence ID" value="XM_007876085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPZ4"/>
    <dbReference type="STRING" id="1069680.M7NPZ4"/>
    <dbReference type="GeneID" id="19895975"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02282"/>
    <dbReference type="eggNOG" id="KOG2201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011154_3_1_1"/>
    <dbReference type="OMA" id="FKNPDIC"/>
    <dbReference type="OrthoDB" id="498611at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24123">
        <property type="entry name" value="ASKHA_NBD_PanK-II_Pank4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000115">
        <property type="entry name" value="Pantothenate kinase PanK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00555">
        <property type="entry name" value="panK_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF20">
        <property type="entry name" value="4'-PHOSPHOPANTETHEINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03630">
        <property type="entry name" value="Fumble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR09327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="378" mass="42360" checksum="7D7458FF1EC605E3" modified="2013-05-29" version="1">MDTVLKTLSVHINLQGARIVAETTPGKTREIALPHHKEEVSHIAVDVGGSLAKVVYITKDIEGGSRFNFTRFETKNIDECISFLSFLCRQYERSRLEGPAMCVMATGGGAFKYYDRLRDELGVEIIREDEMECLIVGLDFFITEISDEVFTYSESGPMKFCEPLPNIYPYLLCNIGSGVSMIKVSGPEKFERIGGSSLGGGTLWGLMSILTNAKTFDEMLEMSKSGDNTVVDMLVGDIYGTNYEKMSLKSTTIASTFGKVFQKKLTKKYDTIQDFQSCFRSEDIAKSLLYAISNNIGQIAYLQARIHELETIYFGGTYIRGHPLTMHTLSYAIRFWSGGTKKAYFLRHEGYLGAVGAFLKHQPRNWGRRRASRINGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQM5</accession>
    <name>M7NQM5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872525.1">
        <property type="nucleotide sequence ID" value="XM_007874334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQM5"/>
    <dbReference type="STRING" id="1069680.M7NQM5"/>
    <dbReference type="GeneID" id="19894324"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00626"/>
    <dbReference type="eggNOG" id="KOG4497">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024072_3_1_1"/>
    <dbReference type="OMA" id="CWHLNGD"/>
    <dbReference type="OrthoDB" id="10257284at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990811">
        <property type="term" value="C:MWP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990810">
        <property type="term" value="P:microtubule anchoring at mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052778">
        <property type="entry name" value="Centrosome-WD_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220">
        <property type="entry name" value="WD REPEAT PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN WRAP73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="455" mass="52400" checksum="92AA202D21E2FA7E" modified="2013-05-29" version="1">MDFTSFFVLNGKVGVVPSLSGSYLASLVYPSRLIIRSTTSLSIKRVINLDPEFCQRILFLKWCYIEGSDKILVADDKNAKAWIMEDEKWELNISDGYGIKNIQWSQNGSEILVWTDFMLKLTVWSLSKDSGSTIHYPKFFSKGYDYRPTSTHFVLITRPASHDFISIFDYSFNPWRLFKKWCLPTMDAQGCSWSQDGKWLAVWESPMEYKILLYTPNGYLLQQYSAYDIGLGIKTVQWNPPTGKFIAVGSFDGKVRFLDSFTSNSVIEITHAATIKFDGVTVWREIMSSMLIPKYEIVPQPVSLPFVRPNMEDPSSFLGVGILSFNRDGTLVATRNDNMPTILWIWSLSDLTPIAILIYCNPIKVVKWCPFNPFLLSLVCSGESKISNCVYLWNYQWDEPRAFSIPKYDFNVRWLRWLEKPQNIDNLERTGIVIGDKEEFVIGYIIDDNVKNIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQN7</accession>
    <name>M7NQN7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02163</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874144.1">
        <property type="nucleotide sequence ID" value="XM_007875953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQN7"/>
    <dbReference type="STRING" id="1069680.M7NQN7"/>
    <dbReference type="GeneID" id="19895856"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02163"/>
    <dbReference type="eggNOG" id="KOG2689">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1111768_0_0_1"/>
    <dbReference type="OMA" id="AQHFPRK"/>
    <dbReference type="OrthoDB" id="10254930at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032435">
        <property type="term" value="P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903094">
        <property type="term" value="P:negative regulation of protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="4">
        <location>
            <begin position="167"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="250" mass="29523" checksum="45CE96695A166FDF" modified="2013-05-29" version="1">MSLNGAEDPDFCENLEDYNEEIVRNEDIEKSGLKMSHVNLEEQIKETVPLTDEEKACKIKELKEKLNEKRMLQKIREEQEARENELIRRKRDREYVQLIEEQKRLAHLREIQLRKEEKRQDLLEKKRIKELIEADKRERKERAEQTLAMKNTASQNFSPAVPKSMINSYNTSRLQIRVEAGKECSLIIRVFSSEDTLRFVAESIFPESGISPDMAIFVSTYPKREYFGNDLDKNLRELQLVPSCVLFLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQP5</accession>
    <name>M7NQP5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FK506-binding protein</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02369</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874374.1">
        <property type="nucleotide sequence ID" value="XM_007876183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQP5"/>
    <dbReference type="STRING" id="1069680.M7NQP5"/>
    <dbReference type="GeneID" id="19896062"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02369"/>
    <dbReference type="eggNOG" id="KOG0552">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022297_3_1_1"/>
    <dbReference type="OMA" id="CPPHMAY"/>
    <dbReference type="OrthoDB" id="77911at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041232">
        <property type="entry name" value="NPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036824">
        <property type="entry name" value="Nucleoplasmin_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023566">
        <property type="entry name" value="PPIase_Fpr3/Fpr4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF19">
        <property type="entry name" value="39 KDA FK506-BINDING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17800">
        <property type="entry name" value="NPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001473">
        <property type="entry name" value="FK506-bp_FPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69203">
        <property type="entry name" value="Nucleoplasmin-like core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="8">
        <location>
            <begin position="310"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="145"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="228"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="396" mass="43590" checksum="E24480E91BDEC98D" modified="2013-05-29" version="1">MVQAVALWGCKVEPGKRVPAHDDEDTAGAFRLTMAAIDSSDKSSKSSTIKVIRRPRFHGDDDNIDDSDDISESDLKELEVEFVLCTLKHGDQYQQSLDLTFSADEEVFFTTSGDCPVYLTGNHVILSDFDDDYDISSNEDELFDKYSDDLDANDSESDELGDDSPKIEELSSSESKASDSEKKRNLLDNGLDGLDNLDSVIRNNGNKQDISKKRILDSGDVDISKLTKKQRKKFKHNSDKSSFSEEKSESNIFSKNNDSESRNFQNSKPSVTFAKDLDQYSTKTSKSKTLEGGVVIEDKVVGKGPQVKDGCRVGVRYIGKLLNGKQFDSNTKGKPFSFVVGSGEVIKGWDVGIKGMSLGGQRRITVPCSMAYGKKALSGIPAGSDLVFEVKLVKMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQQ8</accession>
    <name>M7NQQ8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Vacuolar fusion protein MON1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02383</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 3">Prevacuolar compartment membrane</location>
            <topology evidence="1 3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vacuole membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MON1/SAND family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874389.1">
        <property type="nucleotide sequence ID" value="XM_007876198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQQ8"/>
    <dbReference type="STRING" id="1069680.M7NQQ8"/>
    <dbReference type="GeneID" id="19896076"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02383"/>
    <dbReference type="eggNOG" id="KOG0997">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014574_3_0_1"/>
    <dbReference type="OMA" id="QQPFNAK"/>
    <dbReference type="OrthoDB" id="272411at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043972">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043971">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043970">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004353">
        <property type="entry name" value="Mon1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027">
        <property type="entry name" value="SAND PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027:SF7">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN MON1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19036">
        <property type="entry name" value="Fuz_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19037">
        <property type="entry name" value="Fuz_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19038">
        <property type="entry name" value="Fuz_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01546">
        <property type="entry name" value="YEAST73DUF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="FUZ/MON1/HPS1 first Longin" evidence="4">
        <location>
            <begin position="55"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 second Longin" evidence="5">
        <location>
            <begin position="218"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 third Longin" evidence="6">
        <location>
            <begin position="337"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="445" mass="51820" checksum="081089A4120DC963" modified="2013-05-29" version="1">MHNLNEASKCQKEKINVNPTKDKSCLENYDFSDLKVYNEDSKNKISNMEVQKPKKHFFILSRAGKPIYAKYGDEIIISEYMGIIQTIINLFHKKEDNLKSFTSNNLTVVVLLEGPLYLVGISKLQESEIQIKAQLNILYTQIATVLTLNKLLNIFIHKENFDLRRLLGNTEIFLDALSDMIVEGEPSVLLNGLQCLRLKKTVREKIDSILIKTRAKKLLCGIIASNLCIVSMIKPQNQLFLLFSMIFNTTSFKDETEHWIPLCFPKFDPKGFTYCYITFICDSTALILISTDKDAFFEMREMKQNIINDFRIHGILDIIKIAAETSYTTLDTNTPCIYHFIYKSKVDTQFTMPQWKTSEKNLQKKKIMKIYYKLHSLIHKKPFTKFQLISTQNYTAVAWITPSFDFFAIANPEITKQYLIKNINLVLEWIKKEEHRLFIKSRATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQY0</accession>
    <name>M7NQY0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TATA-box-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00724</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872625.1">
        <property type="nucleotide sequence ID" value="XM_007874434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQY0"/>
    <dbReference type="STRING" id="1069680.M7NQY0"/>
    <dbReference type="GeneID" id="19894422"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00724"/>
    <dbReference type="eggNOG" id="KOG3302">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060161_4_2_1"/>
    <dbReference type="OMA" id="NCEYEPE"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000120">
        <property type="term" value="C:RNA polymerase I transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097718">
        <property type="term" value="F:disordered domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008301">
        <property type="term" value="F:DNA binding, bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001179">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000979">
        <property type="term" value="F:RNA polymerase II core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001092">
        <property type="term" value="F:TFIIA-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001188">
        <property type="term" value="P:RNA polymerase I preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR11128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="246" mass="26989" checksum="83D7AD5829EC7D7E" modified="2013-05-29" version="1">MQNPLTVPLSAAEAASFMAPSSLSFPSSHILMSGAMYPGTRDEKGMEHGVLTSLNQTATNTFAGVSGIVPTLQNIVATVNLDCRLDLKTIALHARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVVTGAKSEDDSKLASRKYARIIQKLGFNAKFTDFKIQNIVGSCDVKFPIRLEGLAYSHGTFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKVREEIYQAFEAIYPVLSEFRKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NR48</accession>
    <name>M7NR48_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PXA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01912</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873888.1">
        <property type="nucleotide sequence ID" value="XM_007875697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NR48"/>
    <dbReference type="STRING" id="1069680.M7NR48"/>
    <dbReference type="GeneID" id="19895606"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01912"/>
    <dbReference type="eggNOG" id="ENOG502RM76">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007315_0_0_1"/>
    <dbReference type="OMA" id="INGWIIH"/>
    <dbReference type="OrthoDB" id="41200at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF47">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 122 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="4">
        <location>
            <begin position="134"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="706"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="707"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="890" mass="101763" checksum="4DCA3DC0A8034283" modified="2013-05-29" version="1">MKEISEPLQPASETSNYEESKEDEDNYRPLFSKLKKNAKSTLIYSRFSVFVKLSNIVSKIHPSIWIFCVFLLVIISHILYIQIFWLMVGLILGVMYQIRTPYMELSQEGEGGIGIVKKESFETLQVQEHLVNLSSMIATSLSLLFDNIIKEYVLHWYYPISNDMSFPKACRVLFDNFFLSLYRHIASRSSYDIMMMFFVQCSSTIIVALRELRSALAFSSDDHNINSLIAAYTAQNPNSALSRLLDRPLQRERFRFESENILKILGKKEDLDCLVLKTFAREMLTIQVFENIVETCSSSDFINEWIIYFYSTDKSRETDQEKDQKKSEAQLAMEEAMAEAAEMTRLLQDKSESQESPISGQSSPIAFNGVITPEKRDYFKNSNITCFASPMRSRASSPDGRYHFKAFSNFKSSSPDRSRLSISDHRETKISGTLPQDIFMEKDISNFPKESLYDAEISLSYVNSELSPKKIIKSKWSIQFLITIEPSGSQVSGWVIIKKYSDFESLHEVLRRLAVVSGLHSFNKELPHWKNVSYEDLRVSLEIYLQKALKSKDLSDSHAMKSFLDKQSKCDSVNFSGKRKSWQQLRTVSDGVRDVIKAPAAGGKAIINALGAVGRKTFLDIPDNIFETEVENSLTDTLEESPVVNSENLLFNASKDDRHIPSCRSSFQSHTEKKDFIKSQTASPNILLDNTASNLTSETCSEELMLEPDRNNDFNEEKKSSHEKTNSNTTKGFSNSDIQLFIDINFCILSEFYSLSPKTWSIRRSLLGILRSLLLRNGGTYVEIVKDAIEEKITNYFTNEKWISEQINEIIMKIWPPNPEKIVKKDSEKLLKEAKHLFLNKTIPDTLKSLVGGSATRESLEIVFESLQEKEFMRGILSSILSDILQVIFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NR71</accession>
    <name>M7NR71_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mak10 subunit, NatC N(Alpha)-terminal acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01932</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAK10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873908.1">
        <property type="nucleotide sequence ID" value="XM_007875717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NR71"/>
    <dbReference type="STRING" id="1069680.M7NR71"/>
    <dbReference type="GeneID" id="19895626"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01932"/>
    <dbReference type="eggNOG" id="KOG2343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011757_0_0_1"/>
    <dbReference type="OMA" id="QMEWIVQ"/>
    <dbReference type="OrthoDB" id="269405at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057983">
        <property type="entry name" value="NAA35-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007244">
        <property type="entry name" value="Naa35_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057982">
        <property type="entry name" value="TPR_NAA35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373">
        <property type="entry name" value="GLUCOSE REPRESSIBLE PROTEIN MAK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373:SF0">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 35, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04112">
        <property type="entry name" value="Mak10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25789">
        <property type="entry name" value="TPR_NAA35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAA35-like N-terminal" evidence="4">
        <location>
            <begin position="37"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="NAA35-like TPR repeats" evidence="5">
        <location>
            <begin position="325"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="711" mass="83829" checksum="D7BA7C0C1BAF8DF7" modified="2013-05-29" version="1">MEKEDIFVLSTFQQNQLSSFKDVTKEFFEALKDLSLGELVHDSSFSLEDSISALEMMDPKMDNGLEMNNEIIWDVEAELNPYKVLGLIDKAFAAEISWQSGYFLSQTVFTNVYIQKLLLERQGVIHINDFYLENKKKQTIYKDLVDVVLWPFMIASIKTCGIFCQIFNKGTLYEEEEVSFNSHGLSLLDNIDTAQILDLLRFSISWLDSHSSKFDEEDRKYIKVIQSRLETKISFLRALDFSSTVDSIKDLEYIINKENLIFDFGQEMDIFFSISVQAKLSTTMPPRPIMILPMDIAFNDFKHICEDFRRILLLSIANPSILTPSNILNFFKYFRAKKPASGIFIRTMLQSLFFSNNNMILNKYPVHQFVMDSISEIYSAKELFNVINKSNETYNDSKYSIFNSINNFIKTATPIYMNIFRIMCHNLSRQRRNFCKLILDLEFLQTEAENIDMQLHFHEDSIQKQDNIYPYIFSSWCFYEKLQIMILICFLGFELELHSSHELSLIYWYLDYLLKIYQTHLNKISSYNVRFFNKKYPTICFSEKNDTILVTQQMKFDQRWTNGLQLLCNSFYKLFLILKHFSLICSPNKPQAPKSFMYKQRFKPFLFLKTPEFLNYETFIKDSDMSDISIVELLKILIDNFSKAKTIFEIIKNTDPKISSMLLCYDDFQNNVKNIVELCLENELTCKIILEKYNHLWFPTISICQNHETLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRF9</accession>
    <name>M7NRF9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipase</fullName>
            <ecNumber evidence="7">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01893</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the phospholipase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="7"/>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873867.1">
        <property type="nucleotide sequence ID" value="XM_007875676.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NRF9"/>
    <dbReference type="GeneID" id="19895587"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01893"/>
    <dbReference type="eggNOG" id="KOG1329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000690_3_2_1"/>
    <dbReference type="OMA" id="DSLWTKH"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000011">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF76">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PX" evidence="10">
        <location>
            <begin position="210"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="9">
        <location>
            <begin position="642"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="9">
        <location>
            <begin position="950"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1428" mass="167704" checksum="331198958FD49174" modified="2013-05-29" version="1">MIGNKFRNRRELDEIENEESLVFSLQSLKENNRSEYLLKDIMDDNYVDIRRSCSNISLRYPSFYCFHKGLQQIPTKTFDDNDSFISDTKIKNILDNMAENRDSVLFHSLTTLSRSVTENDIETKRKKLWGQTRQPFHGLGALSFHENSFFQKWNALKSSIKLRNFKKKEKKNIHKPVKLLSQLEAGVPAVLMFASVFQRDDNGRRRVPILLDQLKIDVLDSKNTKSRSHALFQIKLKYGDGENAVEWSVYREWKDFLNLHTRYRVSETVNGQFKKAQGLPAFPKSSVPYLRGIRGFTSDDSDTCSKKSTKSSKQDRFAETNSEISDVNKKTNFMKNPSFSGMQRRKLEEYLRKMAHLFIFRLEGIRLCSFLELSALGIKLGKYEKYHGKEGLLAVVNSKGSTRKMTCNPIEVRDRSLPKWYLVRESYIVCVNDISSTKIYDVFLMDDGFEIARKHFSKEILSRSSKVKRDNLNKYQPKRHTFKIKNCERQVKLLAKNEITVQQFMENIKDMSKATIWTKFKRFNSFSPVRTNVAAQWIIDGRDYFWNVSRAILNAKETIYIHDWWLSPELYLRRPACVSENWRLDKLLKKKADEGIQIYIIIYRNVGTTVPIDSTYTKYSLLSLSPNIYVQRSPSHLRQSTFFWAHHEKIICIDEKISFIGGIDLCFGRWDSYEHVLYDDKPSGWDEMHNPISRIPEEPLIWPGKDYSNPRIHDFFTLDKPYEDMYNRTLIPRMAWHDISMQIVGQPARDIARHFVQRWNYHLRNKGPRRSIPFLVPPPDFTQEQLEENGFLGTNELQVLRSVGPWSIGTPMKIEHSILNAYVKCIETSEHFIYIENQFFITSSECEGAIIENSIGDALVRRVIKAYKNNEKWRAIIILPLLPGFQNDVDSQEGTSLRLIMHCQYRSICRCKYSIFKRLEAAGIDPIKYIRIYSLRNWAKLGENGRLVTEMVYVHAKCMIVDDRICIIGSANINERSMRGNRDSEIAAIVRDTEMQLSTMAGKSYMVGKFSYTLRVRLMTEHLGINSDELEKVECFMDGLAKNCKWKDMKTWDCDSLSTQETLNDEEKLIKEDFSKKNRQLDELYNEYMLSFQEKDYQYALNEKNEIVYQINSNIPQYKEFKSVPEFSEISFGRRKVTTTTTHLIFGLEVRKVLSDPNYFNINCLSPDSLESKIYEESDIEKQKVCDDTENLDKSKIDSDKLDINCDLYNFEKTNDFTRKKFKSKIPSEKWQKIKIDPLLFSDPLADSFFEDIWDKVAQRNTEIYRQVFRCMPDNEVRTWKEYYNYKRYTEKFMQRYELKKINTNSTQEISEALPSYYQEPYSSFNSTSDSIDNIKTTTMTLSKSTGDLSKEIYETNFVSGYPSAFPDKKTSKNSDEIFLEPQEKLEEKLLKIQGHLVIWPTEWLIEEYDHGNWLSTFDHIPPIDIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRH0</accession>
    <name>M7NRH0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mannose-1-phosphate guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00357</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872230.1">
        <property type="nucleotide sequence ID" value="XM_007874039.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRH0"/>
    <dbReference type="STRING" id="1069680.M7NRH0"/>
    <dbReference type="GeneID" id="19894055"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00357"/>
    <dbReference type="eggNOG" id="KOG1460">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_3_0_1"/>
    <dbReference type="OMA" id="MPVPNWW"/>
    <dbReference type="OrthoDB" id="285674at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06428">
        <property type="entry name" value="M1P_guanylylT_A_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="5">
        <location>
            <begin position="5"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="6">
        <location>
            <begin position="281"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="411" mass="45886" checksum="7C4D204DCF3BA953" modified="2013-05-29" version="1">MSAVAIILVGGPSSGTRFRPLSLDIPKPLFPIGGKPMIWHHLVALSKVETVREVLLIGFYEESVFSGFIKDAKEVFLNFSIKYLREYQSLGTAGGLYFFRDVILRDSPKTIFVLHSDLCCSFPLKNMLKMHLEKDAIGTLLGTKVSPDDANNFGCIVWDTATSEVIHYVEKPETYISSTINCGVYIFDGSIFDQIKESIRLRNERNKEMPSSSFDPDERLRLEQDVLVPLTQTKKLFIYETKDFWRQIKTAGSSVPANALYLLYSQEENDKKFFKDSGPEIVPPVYIHPSASVDHSSKLGPNVSIGLKVKIHSGVRISNAIILDGAEIKPNASVLHSIIGRRCRVGQWARVEGTPTLPTQHNTTILRNGLKVQSITVLANDVTIDDEVRVQNCIVLPHKEIKNGVVGEVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRJ6</accession>
    <name>M7NRJ6_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH-ubiquinone oxidoreductase 49 kDa subunit, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00385</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872259.1">
        <property type="nucleotide sequence ID" value="XM_007874068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRJ6"/>
    <dbReference type="STRING" id="1069680.M7NRJ6"/>
    <dbReference type="GeneID" id="19894083"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00385"/>
    <dbReference type="eggNOG" id="KOG2870">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_1_1_1"/>
    <dbReference type="OMA" id="TRMDYLT"/>
    <dbReference type="OrthoDB" id="1009at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.645.10:FF:000005">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="entry name" value="Cytochrome-c3 Hydrogenase, chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004739">
        <property type="entry name" value="PRK06075.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="HydB/Nqo4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH-quinone oxidoreductase subunit D" evidence="6">
        <location>
            <begin position="191"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="461" mass="52822" checksum="820E4A557FBFE449" modified="2013-05-29" version="1">MNIKRIVFSRYISCRSFLFHLNSLKFRVNYQSLSSITFPKFSEKNDQNLWKTTLTEVKEDGSIIDEKDSKFESKIRHFTVNFGPQHPAAHGVLRLILELNGEEILRADPHIGLLHRGTEKLIEHKTYLQALPYFDRLDYVSMMTNEQCFSLAVEKLLNIEVPERGKFIRTMFGEITRILNHLMAVLSHAMDVGALTPFLWGFEEREKLMEFYERVSGARLHSAYIRPGGVSQDLPLGLLDDIYAWATQFGDRIDETEELLTDNRIWKARTVGIGRVTAMDALNYSFSGPMLRGSGIPWDIRKVAPYDAYDKVEFGVPVGQNGDCYDRYLIRMQELRESLNIIHQCLNKMPEGPVKVDDWKISPPPREVMKENMEALIHHFLLFTKGYCVPPGETYTAIEAPKGEMGVYIVSDGSERPYRCKIRAPGFAHLAGADMISRNHYLPDMVAIIGTMDLVFGEVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRW1</accession>
    <name>M7NRW1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">WAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01772</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873739.1">
        <property type="nucleotide sequence ID" value="XM_007875548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRW1"/>
    <dbReference type="STRING" id="1069680.M7NRW1"/>
    <dbReference type="GeneID" id="19895466"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01772"/>
    <dbReference type="eggNOG" id="KOG1245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002631_1_0_1"/>
    <dbReference type="OMA" id="YANKMGE"/>
    <dbReference type="OrthoDB" id="332390at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028941">
        <property type="entry name" value="WHIM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013136">
        <property type="entry name" value="WSTF_Acf1_Cbp146"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32075">
        <property type="entry name" value="ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32075:SF6">
        <property type="entry name" value="ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02791">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10537">
        <property type="entry name" value="WAC_Acf1_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15613">
        <property type="entry name" value="WSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50827">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51136">
        <property type="entry name" value="WAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WAC" evidence="7">
        <location>
            <begin position="22"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="DDT" evidence="6">
        <location>
            <begin position="289"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="519"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="469"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="805" mass="95261" checksum="2203063C3D0B6291" modified="2013-05-29" version="1">MVLQKRKIIKYASIPENIQEDQQVWYIPITQEVFTEYDDYLTRMDFYNEKIFMCEITGHTNMTYFQAYQSELMHARDIEETFPESLKEPVLRKIQLSLTTRIDYLVDEIYDQFKKDYYPGESLICTLAGEKWEVQVREKTKFNEIISPNGIFRPAHTKYLVEMPEKYKKEDTREEMVDEKVLSRERGSFTKAILRAFIKNVVKKESWTGAPWIIKEKYAKRFKIDIISPKLRKEEIERQLHKKKMEIEGVVGKNARGYPLKYPIEDLDLVPASNVSHRPEFIFETLINKNSISVLLETWTFLNVFCEPLILDSFTLDDYIDSLHYTSLNPPCELINETHCSLLKSLVGERSPLCLSSCMSPSKKEVFNKINVINNNYIGNFGENWRELLQRRILENGKWIIIVIGIINELLKNSLYPEKYDLILKKFNVPHIKESYCEVYYNLNSDDKLRVLEILIELCYNTPLTRNYIEECSESIIQAKKDKQELIKTKKQHLEKIREIRDEIRKLFPGGIPRLEQLSPLEEQMDEETEDEDEEMHENFEPDDQSITNTEDNVLTIKTRSRSGVKRKRTFEEPKIKSQLPDAKTLKQHEKLTQEIKKIKRQIQKIEEDMVINDVNIREADAQRVRVLGYDRFWNRYWWLENNGMPYYGMPDSSTSYAGYATGRIWIQGPSPDIIEKFRQDKILERKQIEEGKTPLASFNDWAYIDTPEKIEELLNWLNPKGIRELKLKNVIQARINFIYQAMDARKKYLSGELIEAKRSTRATLGIDYERERFLNWVNSKAIEYFGCGHSHLQAKKERSSNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRW5</accession>
    <name>M7NRW5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal recognition particle receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_01776</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRP receptor beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873744.1">
        <property type="nucleotide sequence ID" value="XM_007875553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRW5"/>
    <dbReference type="STRING" id="1069680.M7NRW5"/>
    <dbReference type="GeneID" id="19895470"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01776"/>
    <dbReference type="eggNOG" id="KOG0090">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1215204_0_0_1"/>
    <dbReference type="OMA" id="CNKFDLF"/>
    <dbReference type="OrthoDB" id="41266at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019009">
        <property type="entry name" value="SRP_receptor_beta_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09439">
        <property type="entry name" value="SRPRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR10022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="228" mass="26388" checksum="BD1A901723A186C4" modified="2013-05-29" version="1">MVQVEIAAFFTVICLIISLVFLRIFWRYKSLKKIVILGVQGSGKTSFFTKLCYGHKQKAYTSTQLNEAVCCFFPGKKVILVDFPGHLKFYHLFSEIKHIRCIVFMIDSSSMIKNADHVVYQLYRLLKDARSKKIRHILIAANKEDLFTSLPCTKISSIIEEKLSEIVLFRLRGIAEIDKEIDDDDDWLLNSEKTIHLNNIEGFDIAVLTGSVKNDHLSPWTNWMSRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NS23</accession>
    <name>M7NS23_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01671</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873633.1">
        <property type="nucleotide sequence ID" value="XM_007875442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NS23"/>
    <dbReference type="STRING" id="1069680.M7NS23"/>
    <dbReference type="GeneID" id="19895365"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01671"/>
    <dbReference type="eggNOG" id="KOG1167">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_118_2_1"/>
    <dbReference type="OMA" id="FFRCEDD"/>
    <dbReference type="OrthoDB" id="10020333at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031322">
        <property type="term" value="P:ascospore-type prospore-specific spindle pole body remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007135">
        <property type="term" value="P:meiosis II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14019">
        <property type="entry name" value="STKc_Cdc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF23">
        <property type="entry name" value="CDC7 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="41"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="404" mass="46732" checksum="3E3368A8DAE1F252" modified="2013-05-29" version="1">MVYTNLIKRNTKIKFSSDVDKGSIREIEALLSAVPGLEEQYHVLKLIGYGTFSSVFKAIDLKYHEYDNSSWEKGFNSLRYCTRLSVQRTHYVAIKQIYPTQSSHRIIKELKILNELKGKPSVTCAITAFRYQDQVLIVLPYIMHSDFREFYLSYTLSDVSIYIRELFRALSSVHELSIIHRDIKPANFCWNPFSKRGSLVDFGLAQWENEFDASCACSKKHIPSNPGFFDKENMESFKLLEPNNAYIKKDLRPCKKGERGGTRGFRAPEVLFRCKSQRCAIDVWSAGIILLTFFIKRFPLFQSENDIDALVELTHIFGRQEMKNCARLHDCSFDDNIPSVPDSRIAWWQLIKVFSINDNYSIFDGEDNSIINSALDFLEKCLTLNPSERIQSKSALQHPFLNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7NS31</accession>
    <name>M7NS31_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <ecNumber evidence="3 9">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_00008</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="3 9"/>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871858.1">
        <property type="nucleotide sequence ID" value="XM_007873667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NS31"/>
    <dbReference type="STRING" id="1069680.M7NS31"/>
    <dbReference type="GeneID" id="19893706"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00008"/>
    <dbReference type="eggNOG" id="KOG0563">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ERAGYYE"/>
    <dbReference type="OrthoDB" id="60984at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF0">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 9" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="6 9" id="KW-0521">NADP</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="10">
        <location>
            <begin position="25"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="202"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR11563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="499" mass="58168" checksum="EAE48C7C48283FA6" modified="2013-05-29" version="1">MVEFVLKAFNDSDIEAKSKEDITFIVLGASGDLANKKIFPALFQLYQNNLISRKIHVIGYARTKMNNQEFHSRFSSYIKITSKDESVFKEFKNACTYISGKYNNNGFKKLLFHCEEIEDKSQKQSRIFYMALPPNIFNCASYYLKKLLYPESGIARLVIEKPFGKDFESNKKLQKALTCMWKENEIFRIDHYLGKEMVKNLLIMRFSNVFLDASWNKHYISNIRIIFKEPFGVEGRGGYFNEFGIIRDVMQNHLLQILVILAMERPDSFFSDDIRDRKVKILQDIPVIEPKDVIIGQYTCSEDRSKLGYTDDETIPKDSRCPTFAALTMFIENERWKCVPFILIAGKALDEQKVEIRIQYKDAFGEMFGNVLRNELVISIQPEEGIHMNINSKYPGLDMYAVSTKLNFIYKHEFPNIKIPEAYESLLLDAIKGDQSNFVRDDELDHSWRIFTPLLHYLDEHEDIKPILYPYGSGGPSELFDYIKSYGCKLCQINITFYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NS71</accession>
    <name>M7NS71_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_00045</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Lipid-anchor</topology>
            <topology evidence="10">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871898.1">
        <property type="nucleotide sequence ID" value="XM_007873707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NS71"/>
    <dbReference type="STRING" id="1069680.M7NS71"/>
    <dbReference type="GeneID" id="19893743"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00045"/>
    <dbReference type="eggNOG" id="ENOG502QRZZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021855_1_0_1"/>
    <dbReference type="OMA" id="CADFFAC"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF5">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9 10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005141195" description="1,3-beta-glucanosyltransferase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="386"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR11603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="445" mass="50553" checksum="BFFC1195FCA7099A" modified="2013-05-29" version="1">MIFFNGFLIFLLLNKVKIAVNALNPIIIRGNAFFDSITNERFYIKGVDYQPGGSSGIIDPLSNKEACERDFPLMKELGINSIRVYQVDNADNHDYCMDILDKNGIYLFLDVNTALISLWSLNTKSSYTQEYLQNIFATVDAFKKYSNVAGFFAGNEVVASVEQTNALPWVKAVVRDLKKYISLQSSRKIPVGYSATDLNNRVPTAFYLNCGEEAERVDFYAINLYSWCSPSSFTTSGYSQRVVDFFDFTIPIFFSEYGCNRAVPRPFDEVEHIYSSKMIHVFSGGLVYEWTEEKNNPNYGLVIVNGKEVTKKQDYLNLKEQYSKLSFPSNGGGYKIRGGGNECPKDAFSFNVHAALPNVPRGAERYFKNGAGRPLGLRPLGSKNRYIRPIDYNNNPEDTSDTTSDDSNDNTTPSKDKGASTRIYFNLRFYIYFILFIPLFRIYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSA8</accession>
    <name>M7NSA8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein phosphatase PP2A regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_00077</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871933.1">
        <property type="nucleotide sequence ID" value="XM_007873742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSA8"/>
    <dbReference type="STRING" id="1069680.M7NSA8"/>
    <dbReference type="GeneID" id="19893775"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00077"/>
    <dbReference type="eggNOG" id="KOG1354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021713_3_3_1"/>
    <dbReference type="OMA" id="LSHHDTI"/>
    <dbReference type="OrthoDB" id="6274823at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000705">
        <property type="term" value="P:achiasmate meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071475">
        <property type="term" value="P:cellular hyperosmotic salinity response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045143">
        <property type="term" value="P:homologous chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016237">
        <property type="term" value="P:microautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044818">
        <property type="term" value="P:mitotic G2/M transition checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001100">
        <property type="term" value="P:negative regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010515">
        <property type="term" value="P:negative regulation of induction of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031030">
        <property type="term" value="P:negative regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905477">
        <property type="term" value="P:positive regulation of protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900182">
        <property type="term" value="P:positive regulation of protein localization to nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061586">
        <property type="term" value="P:positive regulation of transcription by transcription factor localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018067">
        <property type="entry name" value="PP2A_PR55_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037309">
        <property type="entry name" value="PP2A_PR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01024">
        <property type="entry name" value="PR55_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01025">
        <property type="entry name" value="PR55_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU331113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR11638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="451" mass="51359" checksum="3524C1E340369A4A" modified="2013-05-29" version="1">MIEGIGGSQWKFAQCFGDKGDVEDITEADIISTVEFDHTGDYLATGDKGGRVVLFERNHTKKNCEYRFYTEFQSHEPEFDYLKSLEIEEKINKIKWCKRQNSAHFLLSTNDKTIKLWKVFEKSLKVVAENNLSDGLYSSYITSPDLLKLPRMSHHDTIIASVPRKIYSNAHAYHINSISISSDGETYISADDLRINLWNLNIADQSFNIVDIKPVNMEELTEVITSAEFHPLHCNQFMLSSSKGTIKLIDMRQSALCDQHAKIFEEQEDPSSKSFFSEIISSISNVKFSHDGKFILSRDYLTLKIWDIAMEKHPIKVINMHDKLRSKLCDLYENDCIFDKFECIFSGDGKNVLSGSYNNTLMIYPTDTSNTCSNREIVLHADRSAFKAKKVGGNKKLVRGVSPNLRENGGIDLIDTDNIDFNKKILHSSWHPNEDSIAVAATNNLFIFSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSB6</accession>
    <name>M7NSB6_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873376.1">
        <property type="nucleotide sequence ID" value="XM_007875185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSB6"/>
    <dbReference type="STRING" id="1069680.M7NSB6"/>
    <dbReference type="GeneID" id="19895133"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01436"/>
    <dbReference type="eggNOG" id="KOG1981">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_466237_0_0_1"/>
    <dbReference type="OMA" id="FINAVRM"/>
    <dbReference type="OrthoDB" id="276323at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010737">
        <property type="term" value="P:protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832:SF11">
        <property type="entry name" value="LD23868P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="585" mass="69085" checksum="9D50501B6C7D601C" modified="2013-05-29" version="1">MKCLSPVLSSKRSNDVFDISQNIICSGHKRLRNSDAFCEFSQMSNFHIFRDKFYILKEYNKISHSWLLAESSLSYLLNKHNSTMDSKFIPILLQDSLEMGPHGSVSLKIPIFFSAADYSMFNSYISPPVTQTILRKLELHEIFKNVQFRHDIVHEPNLQFRPNLDGESGKRKRFLASRYWECLLKEIEQVRLFQVKQMNGSNICHKYPCVTRIFVLFLELEDILLNLLPSSSREYIIEILDPDLIVQELLHNLFDVEKFIEHLACILKQHCAPVRDVLLDKMVQKVKLGFKINDLLKFVDGLRMGFDILEMMKLDVANHQLRVLRLYFLETAVEFEQKWFIDRISWGSIDIDDALSWYCYFHDSLITSDLRDFDYRKAFVNGIMASIAYVSLFNFPSTFVFDMPRLMSLRYNIRDIVSFQLIILLFWQLFKKQTIEVSKDDILEFKQELWLIVDSEYGENKWVNNISSITNRIAKYANKTKLISSNNILKLKEFGIIENWLYKHLFPMSSLYRLVESRILKSIGDKMFKSLCFSNPNILAPNVQRELYNMHADMVIEKLTKIVMFHWKVFGKWYIEYAKDRSISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSD3</accession>
    <name>M7NSD3_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cell division control protein 42</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_01785</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873753.1">
        <property type="nucleotide sequence ID" value="XM_007875562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSD3"/>
    <dbReference type="STRING" id="1069680.M7NSD3"/>
    <dbReference type="GeneID" id="19895479"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01785"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_21_3_1"/>
    <dbReference type="OMA" id="GDEPYTF"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01874">
        <property type="entry name" value="Cdc42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000236">
        <property type="entry name" value="Cell division control protein 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037874">
        <property type="entry name" value="Cdc42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 12" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR10031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="191" mass="21280" checksum="62D23E44784FEF29" modified="2013-05-29" version="1">MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGEEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLICFSVTSPASFENVREKWLPEVRHHCPGTPCLIVGTQVDLRDDPMIAEKLSRQRQTPITKELGERLAKELGAVKYVECSALTQKGLKNVFDEAIVCALEPPVTKKKSKCLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NT14</accession>
    <name>M7NT14_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SURF4-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01138</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873052.1">
        <property type="nucleotide sequence ID" value="XM_007874861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NT14"/>
    <dbReference type="STRING" id="1069680.M7NT14"/>
    <dbReference type="GeneID" id="19894835"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01138"/>
    <dbReference type="eggNOG" id="KOG3998">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056195_0_0_1"/>
    <dbReference type="OMA" id="RHRHFPW"/>
    <dbReference type="OrthoDB" id="7859621at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002995">
        <property type="entry name" value="Surf4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02077">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="33696" checksum="CC496594BB1F3DA5" modified="2013-05-29" version="1">MSAERFPSIPISYNSPSSSTSGFQAFQTYVKYFEECVETFLGPVKHYVPALGRFLIIGTFMEDSVRILTQMRDQLYYLEVHRHFYRGLSHAFLIINVIAMLTASFMIVARKKSEIAVGILFGVVIAQAFGYGLIFDKTLFFRNISMTGGLLMVLSDSWSKKQHLFAGLPQLSETDRKKYFLAVGRVLLIFLFTEFIFKETWTTVHVFMLIFSLIACFMVIIGFKAKWSAFFLVCILNIFNILINNWWDTKITEMEKDLLKYDFFQMLSITGGLILLVNMGPGGFSVDEKKKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NT81</accession>
    <name>M7NT81_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01204</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873121.1">
        <property type="nucleotide sequence ID" value="XM_007874930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NT81"/>
    <dbReference type="STRING" id="1069680.M7NT81"/>
    <dbReference type="GeneID" id="19894901"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01204"/>
    <dbReference type="eggNOG" id="KOG0052">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_3_5_1"/>
    <dbReference type="OMA" id="AIRDMGM"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000211">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="5"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR10492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="458" mass="50173" checksum="82CD48656C4665EF" modified="2013-05-29" version="1">MAKDKTHVNVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKGSFKYAWVLDKLKAERERGITIDIALWKFETSKYYVTVIDAPGHRDFIKNMITGTSQADCAILIIASGTGEFEAGISKDGQTREHALLAYTLGVKQLIVAVNKMDNTNWSESRFDEIVKETSNFIKKVGYNPATVPFVPISGWHGDNMVEESPNMPWFKGWTKDCKNTVLKGKTLIEAIDSIEPPVRPSDKPLRLPLQDVYKIGGIGTVPVGRVETGIIKPGMVVTFAPSGLTTEVKSVEMHHEQLTEALPGDNVGFNVKNVSVKEIRRGNVAGDSKNDPPKGCEGFLSQVIILNHPGQISAGYAPVLDCHTAHIACKFFNISEKIDRRTGKKIEDNPKFVKSGDACIVDMVPSKPMCVESFTDYPPLGRFAVRDMRQTVAVGVIKSVSKIEKAGKVTKAAQKASKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTA1</accession>
    <name>M7NTA1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA topoisomerase</fullName>
            <ecNumber evidence="6">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01223</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="6"/>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873141.1">
        <property type="nucleotide sequence ID" value="XM_007874950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTA1"/>
    <dbReference type="STRING" id="1069680.M7NTA1"/>
    <dbReference type="GeneID" id="19894920"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01223"/>
    <dbReference type="eggNOG" id="KOG1956">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002929_1_1_1"/>
    <dbReference type="OMA" id="VIHNVYS"/>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140226">
        <property type="term" value="F:RNA topoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000018">
        <property type="term" value="P:regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.140:FF:000003">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF21">
        <property type="entry name" value="DNA TOPOISOMERASE 3-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPO_IA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="7">
        <location>
            <begin position="2"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="8">
        <location>
            <begin position="166"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="617" mass="71390" checksum="D8BC24BEE481DF63" modified="2013-05-29" version="1">MKILCVAEKPSIARAISDILGGGKVHIRETKDVYNKNYDIRFKFNFSWGDSSVTITSVRGHLIEWEFEEKFKKWNSCNPLNLFEAKIIPTVNKDMKNIHDNILKESQNAHGLYIWTDCDREGEYIGTEIVNIARKANPKIEVKRAHFNNLERMHIIKAAHRPFDIDQKQVNAVAARIEFDLKTGSAFTRFQTLSLQSFEPLAKEIISYGSCQFPTLGFVVDRWKRVENFVSEKFWSIKVICSYNNNQISFNWKRIRLFDKLSVFLIYENCLLFDKAKVISVVRKPKSKLPYPLTTVELQKRGTKYLGISSKDIMTIAETLYTKGFISYPRTETDQFDDDIDLRSLIEKQVNDEQWGNYAQNLLNEKFCHPKKGKNNDKAHAPIHPVTYVKKNSLKSVNEHKVYSFIVRHFLACCSQDAKAKQTVIVIQWGEEFFSTSALIILENNYLDIYLYEKWNSSVSLPDFNQGEMIELDYTEMIEGKTESPGHLTESELINLMNINGIGTDSTIAEHIQKILDRKYVFKQSKNKNKKSQNNTIYEFIPSTLGIALVDGYDKIGFDQSLAKPFLRKEMELKLKNICDGKSSKEEFLKDIISQYKNLFIKANQKVDILKEVANIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTT9</accession>
    <name>M7NTT9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Raptor N-terminal CASPase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00838</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat RAPTOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872747.1">
        <property type="nucleotide sequence ID" value="XM_007874556.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NTT9"/>
    <dbReference type="GeneID" id="19894536"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00838"/>
    <dbReference type="eggNOG" id="KOG1517">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001136_0_2_1"/>
    <dbReference type="OMA" id="TEVCTND"/>
    <dbReference type="OrthoDB" id="10262360at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030874">
        <property type="term" value="C:nucleolar chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031139">
        <property type="term" value="P:positive regulation of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032682">
        <property type="entry name" value="Cnd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004083">
        <property type="entry name" value="Raptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029347">
        <property type="entry name" value="Raptor_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848:SF16">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12717">
        <property type="entry name" value="Cnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14538">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01547">
        <property type="entry name" value="YEAST176DUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM01302">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Raptor N-terminal CASPase-like" evidence="5">
        <location>
            <begin position="136"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1208"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1251"/>
            <end position="1292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1340" mass="153025" checksum="4609DA7A4D46F0CD" modified="2013-05-29" version="1">MKDSNVDRERIINFSIFKRNEIQTNSTIETKDFNKTIIKYFDSIETKEENNKDIKKDKDLKEKYVNTLVTKTSSKNNEVKIQAIKVRHGFKNKDLEKCNTIGENIFYMHYTAKRHETCGIPRLKNEKLQDWRMRERLKTVSAALCICMNIGVDPPDIVKTTPCAKLECWIDPFSLPSQKSLEAIGKNLQQQYETLSTRTRYKQYLDPSIEETKKFCSAQRRNAKDERILFHYNGHGVPRPTESGEIWVFNKNYTQYIPISLYDLQTWLGSPCLYVYDCSAAGNILINFNKFAEQRDAETQKQRAFDSTIPISSLQKESIQLAACGPREWLPMNPDLPADLFTCCLTSPIEIAVRWFVLQNPFLSNITIDMVMRIPGRLQDRRTPLGELNWIFTAITDTIAWNILPKPLFKKLFRQDLMVAALFRNFLLAERIMRVHQCHPMSYPSLPPTYHHPMWNSWDLAVDTCLAQLPQLLEAENGGPAYEYKHSTFFREQLTAFEVWLEQGSVFKKAPDQLPIVLQVLLSQVHRLGALILLSRFLDLGPWAVNLALSIGIFPYVLKLLQSPASELKPVLIFIWTRILAVDGSCQSDLLKDDGYSYFVQILSPSCGNLSVANVSEHRAMCTFILSIFSRNFTQGQTACLNSGVLQANHVHLRDKDPLLRQWSCLCISQIWKDFSDAKLLCIKEGIVDSLCDLLSDPVPEVRAASLFALTTFLSHPIEDKEVIAKEDYVVTSVLNLSLDGSNLVRKELIVFLSRYVSHYNKKIMVTAFEHLMHEFFNFGLNDSKFQKPLVNYSTNSLFLTVWKTLLLLTVDPFLEVELASIHVVNKIYNMLIKSQLGSTTKFIVEKVIGIKNDTTYKSKLHSSTNENIKSTSFGTQQTPSTSKLTNTLKCSTSIALSLKNLKIGTYNEASALESNLSFDEDIHHRSANHHSTLIKPFPKNFNLKFYKSSKHIIQSTFFDWSCEYFQEPQMKPAEADEPGSVNYNQRLWRRNRNEKIINEACSLKDIADSLSWSNQICNLKSGFAQISHLLFHQFESHLICTDDQDNVEVWDWESGIKLNQFSNNNTFGARITGIKFINEDDIGYILVGSSDGIIRIYKNYDTESIELVTAWRALTDIIPLNRGNGLVIDWQQKRGILFVGGEAEIIKIWDTSQEMCLNNISTKSRNCITSITSDEVDGNIFVASFGDGTIRIYDQRNSPRDAIVRIWKEHKTWIPTISMQKCGNRELVSGSISGDVKLWDIRLDNSIRTINTHSDGLRSLSVHEHIPCIATGSTNSDLKVWNTDGSNLSAFKYYYSFLHQGKPTSVNALNFHPHKAILACANGNDSHINIFTCDIGRNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTW1</accession>
    <name>M7NTW1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ADP-ribosylation factor-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01257</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873180.1">
        <property type="nucleotide sequence ID" value="XM_007874989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTW1"/>
    <dbReference type="STRING" id="1069680.M7NTW1"/>
    <dbReference type="GeneID" id="19894954"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01257"/>
    <dbReference type="eggNOG" id="KOG0073">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_12_0_1"/>
    <dbReference type="OMA" id="KTHHWQI"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001166">
        <property type="entry name" value="ADP-ribosylation factor D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="21287" checksum="51BB3E4CC8B99E2B" modified="2013-05-29" version="1">MGLYTIIKKQRRKDKEIRILMLGLDNAGKSTIVKKISGEDVTTISPTVGFNIKTLIWDCYKLNIWDIGGQKVLRGYWRNYFECTDAIVWTVDLTDRMRVKECCEVLKILLKEDRLLGTSLLILGNKCDMESGMDIEELKSYLELEDITSHSYNIFKVSALLGLKLYDAFKWLIEDIEKKKYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NV09</accession>
    <name>M7NV09_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00733</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872634.1">
        <property type="nucleotide sequence ID" value="XM_007874443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NV09"/>
    <dbReference type="STRING" id="1069680.M7NV09"/>
    <dbReference type="GeneID" id="19894431"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00733"/>
    <dbReference type="eggNOG" id="KOG3053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026793_0_0_1"/>
    <dbReference type="OMA" id="KRYCWVC"/>
    <dbReference type="OrthoDB" id="5817083at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46283">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="9">
        <location>
            <begin position="36"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="375" mass="43463" checksum="00CD9FAC7238DFEB" modified="2013-05-29" version="1">METFSHTIVGEHSLFPKDQCLDNEKNELTEILDIKKTSSNLERCWICFDDILEGLNDKGSWRSPCRCGLIGHEKCLLTWITESQKTDLSDKPVLCPQCKCPLRLKDSSTFTFWFLSKIDKVLRKSVPIFIVCGLGSSALISAAFYGIHTIYTICGEKDAQKIMEFEMNNEYFWKLAFGLPSIPFILIFSQFSQFDTIIPIIPLIFFGDQALDISRPLSPTFTLCILPWIRIIYNSIYRHFIIPIHRRFGQELYPQREISGYYPSEHQSIRQTNTRTQENEENHDIRGRMVVFEDIDFGRMIVGTLMFPKISSIIGSCIMKIPGAKKWIPSKFHCSVIGGCLFIVLKDAISLFYKYQKVKQRRSRRVLNYNENLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVN7</accession>
    <name>M7NVN7_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Plasma membrane proteolipid 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_03601</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11357.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613318.1">
        <property type="nucleotide sequence ID" value="XM_019757759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVN7"/>
    <dbReference type="STRING" id="1069680.M7NVN7"/>
    <dbReference type="GeneID" id="19897288"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03601"/>
    <dbReference type="HOGENOM" id="CLU_2942804_0_0_1"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF42">
        <property type="entry name" value="UPF0057 MEMBRANE PROTEIN ZK632.10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01309">
        <property type="entry name" value="UPF0057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR11357.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="45" mass="4984" checksum="3750454088AF4D6F" modified="2016-03-16" version="2">MALTCTDIIKFLFAIIFPPLGVFLEKGCCIDLLINILLTLLGYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVY2</accession>
    <name>M7NVY2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
            <ecNumber evidence="3 14">2.4.1.258</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dol-P-Man-dependent alpha(1-3)-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_00301</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the first dolichyl beta-D-mannosyl phosphate derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-dolichol to produce Man(6)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29527"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="Rhea" id="RHEA-COMP:19517"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="ChEBI" id="CHEBI:132516"/>
            <dbReference type="EC" id="2.4.1.258"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12 14">
            <dbReference type="Rhea" id="RHEA:29528"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyltransferase ALG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.258" evidence="3 14"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872173.1">
        <property type="nucleotide sequence ID" value="XM_007873982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVY2"/>
    <dbReference type="STRING" id="1069680.M7NVY2"/>
    <dbReference type="GeneID" id="19893999"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00301"/>
    <dbReference type="eggNOG" id="KOG2762">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035382_3_0_1"/>
    <dbReference type="OMA" id="PERYGIH"/>
    <dbReference type="OrthoDB" id="20028at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052925">
        <property type="term" value="F:dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007873">
        <property type="entry name" value="Glycosyltransferase_ALG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646:SF0">
        <property type="entry name" value="DOL-P-MAN:MAN(5)GLCNAC(2)-PP-DOL ALPHA-1,3-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646">
        <property type="entry name" value="NOT56 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05208">
        <property type="entry name" value="ALG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR11271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="410" mass="48810" checksum="76C44ACDF939E028" modified="2013-05-29" version="1">MIKSYLFFFIKTYHKARSILHGSSYAYYVSLSLLFLDAFFCLVILLKIPYTEIDWNTYMSQVSIYLSGERNYVNIKGDTGPVVYPSGFLYLYSVLYKLTDGGINIARAQYIFMLVYLLTLFFIFKIYYTIKAPLYTYFMLIFSKRLHSIYLLRLFNDCWAMLFSYIGIYAYVRNSWTLGTFFFGIALGIKMNVLLFFPAIVMILFQILGLRRMLYHFFLIFCIQTLLFIPFISYKKEYISRAFDFSRVFLYEWTVNWKFLSEDIFFSKEFSLLLLFIHVLILFVFSNTLWNRISGRSLKELALSLLNTKTLFINNVYKASFQTQRLIVIILFTSNLIGVLCARSLHYQFYSWFAWTIPYILSQTRIHPFLQFFIWALQEYAWNIYPSTTYSSIIVIMVLVSVLFLLLIRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NW37</accession>
    <name>M7NW37_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DBF4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872238.1">
        <property type="nucleotide sequence ID" value="XM_007874047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NW37"/>
    <dbReference type="STRING" id="1069680.M7NW37"/>
    <dbReference type="GeneID" id="19894063"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00365"/>
    <dbReference type="eggNOG" id="KOG4139">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023948_0_0_1"/>
    <dbReference type="OMA" id="GMKIWAI"/>
    <dbReference type="OrthoDB" id="21380at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031431">
        <property type="term" value="C:Dbf4-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010571">
        <property type="term" value="P:positive regulation of nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901987">
        <property type="term" value="P:regulation of cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3410:FF:000001">
        <property type="entry name" value="Protein DBF4 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3410">
        <property type="entry name" value="DBF zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055116">
        <property type="entry name" value="DBF4_BRCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013939">
        <property type="entry name" value="Regulatory_Dfp1/Him1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051590">
        <property type="entry name" value="Replication_Regulatory_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006572">
        <property type="entry name" value="Znf_DBF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038545">
        <property type="entry name" value="Znf_DBF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375">
        <property type="entry name" value="ACTIVATOR OF S-PHASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375:SF26">
        <property type="entry name" value="PROTEIN CHIFFON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22437">
        <property type="entry name" value="DBF4_BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08630">
        <property type="entry name" value="Dfp1_Him1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07535">
        <property type="entry name" value="zf-DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00586">
        <property type="entry name" value="ZnF_DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51265">
        <property type="entry name" value="ZF_DBF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BRCT" evidence="5">
        <location>
            <begin position="107"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="DBF4-type" evidence="6">
        <location>
            <begin position="468"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="61280" checksum="CF7B05848B10ED4A" modified="2013-05-29" version="1">MVEHKTNERQPLIARSMNLQFPSIYQQHHQNSEHEISPILKRVLIESPVQKVVDIETVNRKAIKRTKHESPTKSKTLAQTHLISTESWKRTFSIEETNAKVREWQRQYRKAFPSFRFYFDSVDQNVKHKITKQINKLGGTVEAFFSRNITHVITTRPIPDFTNISLQLAQKSSLNSNNTFSMFSASQNRSRKLFGLSDLLKDSCITSKLNQEELLKNDVLIKAHEYDIKIWSFDKFVNRILRSLLDPSLTPNQPKLSHLLYDEKVNGTRERDRATPREDYVYFKGPYLFVRDISNIYRPIIVKEWPKPPNGKISEGEWPQFRITELGHCPFIRDNARKSHPPSSLQKHKVLKELQNIPEPSKDLKEVLYRLKDDSSKIYNQVQSKRYQTDTNASGIIQSNLTSATRSQTSTNARSGGMAGSITIPLSKSVDDLKRKIFIQVQRRSIHENMNVFQQSQIDPTDKKKIKIESRPGYCENCREKFENFDQHINSRRHTKYAANDQNFIELDELLSTLKRKQLPWNIQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWI6</accession>
    <name>M7NWI6_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872417.1">
        <property type="nucleotide sequence ID" value="XM_007874226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWI6"/>
    <dbReference type="STRING" id="1069680.M7NWI6"/>
    <dbReference type="GeneID" id="19894227"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00529"/>
    <dbReference type="eggNOG" id="ENOG502S6YK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148782_1_1_1"/>
    <dbReference type="OMA" id="EKEWRYN"/>
    <dbReference type="OrthoDB" id="2100988at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34286">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34286:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="77" mass="9168" checksum="B9D05C6624849D7B" modified="2013-05-29" version="1">MVENHQLFPKHVWSPSGGWWCQPRKWKSNTAICIAGISLIVFWVWKTSVEKEWRYNKPSGWIPSLLWSKGLKEQNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NXB2</accession>
    <name>M7NXB2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_00222</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872091.1">
        <property type="nucleotide sequence ID" value="XM_007873900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NXB2"/>
    <dbReference type="STRING" id="1069680.M7NXB2"/>
    <dbReference type="GeneID" id="19893920"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00222"/>
    <dbReference type="eggNOG" id="KOG0475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003181_2_0_1"/>
    <dbReference type="OMA" id="TDWVHDT"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000013">
        <property type="entry name" value="Voltage-gated chloride channel (ClcA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF3">
        <property type="entry name" value="CLC CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="472"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="554"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="622"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="798"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR11796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="855" mass="96575" checksum="9AFA3435282FDBE8" modified="2013-05-29" version="1">MEHQSDFQTFKKSHKHQYMKQDIPDPSSKETENTFLIFPSSRKNVKNYGGIQQYSTTPQLNEDKFSSICKTKMFCNSIHKKFSKKIFNKTFEDEDHKNLNGEHIWYDNYNAIDWIHDTIKDATRAKKLRSIKGIRGWIRNTFDASQGWILVFFTGFITSCVAYVIDVVETIFFDWKFGYCSVTLILLTFITDNIDDLVGCKQWNTWGKHFNFPRKQQWIIDYLVYIAIALLFALISVQLTMTTRTTFPVSMENSSENLSQNISIKKKNNSRAEKVAYMASGSGIPEVKTILSGFTIHKFLGFRTLVVKVIGLTLSVASGLNLGKEGPFVHIACCIGNIACRLFNKYNYNDGKRRELLSAASAAGVAVAFGAPIGGVLFSLEEVSYFFPSKTMWRSFFCAMVAAITLKILNPYGTGKVVLLETHYSHEWHSLELFIFLFLGLFGGLYGSLFCKLNIHWAKTFRRLSFIKKHPIFEVFIVTLFTAIISYHNPYTKLGGTELVSHLLKECNNNELNEGLCPENKLMIPKVTILLILALIIKGSFTIVTFGTKIPAGIFIPTMAIGALFGRFVGLIVQFFYYTYPSAYIFSRCPLGDPNECIVPGVYSMVGAAATLAGVTRMTVSLAVIMFELTGSLSYVMPFMLSILVSKWVADAIEPQGIYDLLIDLNEYPYLDTKSKYTFSSYLSELLPPPITVYHTTIDLSFNSTVSYTKLRDMLKYVKNEGYIDGGFPIVYNKTLIGYIAAHELEHALDTIKSTVSNEDIEKIGCYLMPFGVTDSTSSLDTGTSYSLPDPADLRSYVDKAPISLNKEAPMELVFEMFSKLGLRYLCILDGAEFVGVVHKKRFVRYLKEIEKGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6B9</accession>
    <name>M7P6B9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Pentafunctional AROM polypeptide</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-dehydroquinate synthase</fullName>
                <shortName evidence="21">DHQS</shortName>
                <ecNumber evidence="21">4.2.3.4</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
                <ecNumber evidence="21">2.5.1.19</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="21">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
                <shortName evidence="21">EPSP synthase</shortName>
                <shortName evidence="21">EPSPS</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">Shikimate kinase</fullName>
                <shortName evidence="21">SK</shortName>
                <ecNumber evidence="21">2.7.1.71</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-dehydroquinate dehydratase</fullName>
                <shortName evidence="21">3-dehydroquinase</shortName>
                <ecNumber evidence="21">4.2.1.10</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">Shikimate dehydrogenase</fullName>
                <ecNumber evidence="21">1.1.1.25</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="27" type="ORF">PNEG_02355</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20 21 22">The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:21257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 21 22">
            <text>shikimate + ATP = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>shikimate + NADP(+) = 3-dehydroshikimate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21 22">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="21 22">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21 22">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 21 22">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 2nd section; belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 3rd section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 4th section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the C-terminal section; belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="22">In the N-terminal section; belongs to the dehydroquinate synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="21"/>
    <dbReference type="EC" id="2.5.1.19" evidence="21"/>
    <dbReference type="EC" id="2.7.1.71" evidence="21"/>
    <dbReference type="EC" id="4.2.1.10" evidence="21"/>
    <dbReference type="EC" id="1.1.1.25" evidence="21"/>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874359.1">
        <property type="nucleotide sequence ID" value="XM_007876168.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7P6B9"/>
    <dbReference type="GeneID" id="19896048"/>
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            <position position="160"/>
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00054455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRNR" id="PIRNR000514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF24621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="EMR09410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1584" mass="178441" checksum="23F135B3A233E685" modified="2013-05-29" version="1">MKDEEIIKLNILGKDSIHIGLHLWPHIINELFTYIFSPTYVIITDSNIETLYIPNFKTYFISMAKQKSINSRLLFFTIPPGEKSKSRKTKALIEDWLLSEKCTRDTVIIAIGGGVIGDLVGYVSATFMRGVRFIQIPTTLLAMVDSSIGGKNSINTPYGKNLIGTIWQPERIFIDFTFLETLTEKEFINGIAELIKTIIIWDESEFATLENISEKIAKKVRSMSLTSNKHSKLNEIIKDLKRYIISSIKIKAHIVSIDEKEKDLRTLLNFGHSIGHAIETILAPHILHGESISIGMVKEAELSRYLGILNPNVVSRLIKCLNTWGLPTSLKDRRFKEVTLGKKHLIEDILEIMTIDKKNDSSNKKIVLLSAIGKTYEKKASLVSDNDIRTILSQNILLYGIPLNAFQKHTTITLPGSKSISNRALILASLSNGICYLKNFLHSDDTYYMLSALEKLNAAEFKWGQDGDVLVVKGKSGYLENPQMELYLGNSGTTARFLTSICALVPPDSNKNHLILTGSHRMKQRPIGPLVDALRNNGCCIEYLESENCLPLLIKPRKLGFCGGHISLSATISSQYVSSILMCSPYAKTQVTLSLIEGKPISQPYIDMTISMMSSFGINITRSHSKENTYYIPKGCYTCPSEYIIEGDASSATYPLAIAAITGGSCTISNVGSISLQGDSKFAEYILKPMGCEVVQSPTTTYIKGPPKGKLKSLGTINMELMTDTFLTAAVLASVAYEESKPYITKITGISNQRIKECNRIDAMICELKKFGIEAGELPDGIYVKAQNISNLSYPVEGINCYNDHRIAMSFSVLACISQKPTTILDKACVNKTWPYWWDILNSAFKVQMKGIEFDLNPEINSSILHHPSKCTIFLIGMRGVGKTTLGQLAADFLGRKFIDLDSIIEEDIKTTILEFIQKYNWDAFRRKELHFLKTLLTEKKENYIVSCGGGIIETEEARNLLISYIKANGIVIHIHRNIQDITKYLNTDKTRPAYQDDIMHVWEKRKRWYNLCSSHQFHMISIDSTKFKKRDIPLNLKSSFNNFLRTITGKNDIFSLILKKKRSYFLSLAFSDLENIFSLLDIITTGCNAIELRIDLFQKPEEIGKYPSLEYIAEKISLLRQKTNLPLIYTLRTTNHGGSFPSSEKKLAKEYILHGAKLGFEFLDIELDIASELFKTINNSWPYVKIIVSFHNIKRPISCDDFEWIQKYKEAQHYGQIIKLVGTSSSIEDNFLLEEFKNKIINKKIPSIIINTGIKGQLSRLMNTFMTPVTHPLLPSKIAPGQLSIKEINTALHIMGLLPEKKYFLFGKPIKYSQSPNIHNLGFEILGLPYKYQLFETDSISELKEILHLEDFGGASVTIPLKTNISILLDEISDHAALIGSVNTITKIYNNGQYILKGENTDWQGIIKVINNFNKSEKSFESFSGFIIGAGGASRAAIYALLSLGISPIYVINRSKDKLNKLHYFFNTDRIIPITEYHELNNINFDIRIGISTIPADNPIDPSVLEIAKNLFNLKRKSSEGIFLDMAYGSDTTELISIAEAYNWKTIHGLEILLEQGSEQFLLWTETYIPYNQVKYAILGPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6H3</accession>
    <name>M7P6H3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein bL33m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02062</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874043.1">
        <property type="nucleotide sequence ID" value="XM_007875852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P6H3"/>
    <dbReference type="STRING" id="1069680.M7P6H3"/>
    <dbReference type="GeneID" id="19895756"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02062"/>
    <dbReference type="eggNOG" id="KOG3505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190949_1_1_1"/>
    <dbReference type="OMA" id="TCFNVKR"/>
    <dbReference type="OrthoDB" id="275534at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="entry name" value="Ribosomal protein L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052008">
        <property type="entry name" value="Mitoribosomal_protein_bL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_bL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="Ribosomal_bL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47037">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L33, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47037:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL33M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="56" mass="6503" checksum="1467919B9B2F8B96" modified="2013-05-29" version="1">MAKKPKSRIILVKLLSTVGTGWFYTANRPRLSPKLSCIKFDPRVNKRVLFEEVKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6P3</accession>
    <name>M7P6P3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RIC1 C-terminal alpha solenoid region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02142</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874122.1">
        <property type="nucleotide sequence ID" value="XM_007875931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P6P3"/>
    <dbReference type="STRING" id="1069680.M7P6P3"/>
    <dbReference type="GeneID" id="19895835"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02142"/>
    <dbReference type="eggNOG" id="KOG2006">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002060_1_0_1"/>
    <dbReference type="OMA" id="MVYDRAM"/>
    <dbReference type="OrthoDB" id="67540at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034066">
        <property type="term" value="C:Ric1-Rgp1 guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040096">
        <property type="entry name" value="Ric1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009771">
        <property type="entry name" value="RIC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746:SF10">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR SUBUNIT RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746">
        <property type="entry name" value="RAB6A-GEF COMPLEX PARTNER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25440">
        <property type="entry name" value="Beta-prop_RIC1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07064">
        <property type="entry name" value="RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIC1 C-terminal alpha solenoid region" evidence="3">
        <location>
            <begin position="758"/>
            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR09555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="933" mass="108740" checksum="C3621AAEC92AE50D" modified="2013-05-29" version="1">MYWPVGIPSVFQLKNDFLMGLEYTSISRGETILALKKFHNGTHFIVLTSKRIYVWQIRPTVLISCITRSAISLTLYGENRDFFIMKDSEFAIIKTSLGFLVIYSIHNNLDQKLYKFHYSHNKTTVFDFLDSHGLTEYELLYLKFRSMIKVDSGLLCVLALDECLLFSTFNPPSVQSVSQKEFNHTITMSDDVAHMEWIEDKNVAINNMIYEKTMNIYIWITSNSKAYLVRKNPSVKSRNQENIRNWTGICFYVPETEENYIVKTDINIRLSLIAFGCKNGEIKIFYIEKSKNLISYLYTIILDDFSVTGNIECMSWSEDGCVIFVGFQNTWSLWSAYGNLLCSKPNVENVSENSNEEIFMGGVSHALWFNEGAELIIVSNKEKSDGKLWKINMARSIRRFSLNSENSLNFILQISDVFLIYKGHEESDIDIINPKQIHWKHVQIPLNYFYDNWSIKYIAISACSEHLAIAGYYGMAYYNFKTERWKIIVKDTNFSFRISGGMCWYQDVLIASTSINNTYGLKLFSRKKTVDNIEVLSFIDIGVPIYLLTLISENLLLYTGNNLIFQYLIIMNDFKVKLVLVGSINLKDIVYYPKSLRAFTWCFLSDQMQNGRFINNIHMASIILLVDDKLMFLKPKKNDPALKYNIYLLSEKVEYFLFIDHLSQYLRPSICAFCGTEIKIWMDFSNIIDDTDNQSDDESFLNLKNDCNLITIPLDFYPVFFLLNKGVILGIKNTVIQQRNLDFFNFKFDIMTTLFLPYILEKYLDRTTIKESIILASKYQKLVYFNHILELLLYNVLEKEINCLKDFDPLLPKVASFLNHFPKMLDIVASCARKIEISFWKNLFSVIGTPRELFEKCMELDKLETATEYLIILHTMESTEDMDKNIIRVLEKAVLLKKWKLCSELARFSVSYNNEIILKKFILSFPDILGIHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7P746</accession>
    <name>M7P746_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial import receptor subunit TOM70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_01887</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Tom70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873861.1">
        <property type="nucleotide sequence ID" value="XM_007875670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P746"/>
    <dbReference type="STRING" id="1069680.M7P746"/>
    <dbReference type="GeneID" id="19895581"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01887"/>
    <dbReference type="eggNOG" id="KOG0547">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017516_0_1_1"/>
    <dbReference type="OMA" id="QWRGDIE"/>
    <dbReference type="OrthoDB" id="2942533at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="331"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="399"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="467"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR09700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="615" mass="70048" checksum="E983689B1B987F81" modified="2013-05-29" version="1">MLLASLGGALSGFEAYLLRFQNKDTEWFWKRAIRFFLGRRVLIYSAGVFFVFLSLGSTFYLYRGLSKDDTVGLDKKHGGYKKKPKNKKKRKVRITENDSVTKDGIQTLELLDEELVLTEDKIGKLSESELKAHSTKLKIEGNKAYSRKEYDKAIEFYTHAISCSKDPVFYSNRAACYIALNKPEQVIEDTTMALSLDSTYVKALNRRAAAYEMLNKNDEALLDYTTSCIMDGFSNENAAQSVERLLKKIAEEKAKAIMMTKKKQLPSPTFITAYLDAFRPRPIPKIETKDEASGDYHLKQGFKALLAKNYDNASKSFYKAIELECSNSLKSLAYNMSGTFKFIQGSTLEALEDFNKAIELDPTDTQNYIKRASVHMELGDRSATWSDFDTAQSVNPKDPDIYYHRGQMHFITGEFSEAAKDYQKSIDLDKEFIFSHIQYGVVQYKLGNTALSMSIFRKCLKMFQKSSDVYNYYGELLLDQQRFQDAIEKFDTAIQLEKSSKFTIMNVLPLINKALAVFQWKKDIIEAEKLCKRALAIDPGCDVAVATIAQLLLQQGKIEDAIEYFNKSAQLARTESELVNALSYCEATKIQLQVTRKYPHLAERLNNITKGNFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M7P828</accession>
    <name>M7P828_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873752.1">
        <property type="nucleotide sequence ID" value="XM_007875561.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P828"/>
    <dbReference type="GeneID" id="19895478"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01784"/>
    <dbReference type="HOGENOM" id="CLU_1294891_0_0_1"/>
    <dbReference type="OrthoDB" id="5416122at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="213" mass="24416" checksum="14C73B84C01F5971" modified="2013-05-29" version="1">MPRPIRHPRDSIILEYSHSFSSGPQASSTPTQDPSNITWVSDLSPIGTSASNKNTVIQEDTSPDPFGFREIRGIRPTFRAIHSKPSPKDLEICEKETSSDSLSSQEKSPSLRSTDDEEHLKLSSKKKSTGIKPKDLKYEENKNNELPKKRRYTRKDQNLTKNIEEEEIYKKDINTDGFKKQTMSSKDIIEYFREVDKFELDVEDVPADYTSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7P8Q4</accession>
    <name>M7P8Q4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PNEG_01497</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873437.1">
        <property type="nucleotide sequence ID" value="XM_007875246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P8Q4"/>
    <dbReference type="STRING" id="1069680.M7P8Q4"/>
    <dbReference type="GeneID" id="19895193"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01497"/>
    <dbReference type="eggNOG" id="KOG0201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="OMA" id="ACEPIKR"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000411">
        <property type="entry name" value="Probable Ste20-like kinase Don3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF27">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="6"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMR10225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="390" mass="44191" checksum="A2DE38CF300BAD4A" modified="2013-05-29" version="1">MDDAQYTLLEKLGTGSFGVVWKAVRRKTGEIVAIKQIDLESTDDDITEIQKEIALLSGCDSRYVTKYYSSFVKGHKLWIVMEYMAGGSALDLLKPGPFTEAQIAILCKELLEGLCYLHSEGKIHRDIKAANVLLSFSGQVKLADFGVAAQLSSHKSRRNTFVGTPFWMAPEVIRQSGYDYKADVWSLGITAIELARGEPPLSEYHPMRVLFLIPKAKPPVLEGNYSKEFKDFVSLCLIKDARARPSAKDLLKHKFIKSAGKPSLLQELLERRQEWDIRRGDRPHRTYVETIDTLPIDNHEEWNFDTIKPNILLESESTGTIRKDIQETTTALRRIDLNVYDSDTIKAHSYNVQSNPSKNEISPTLITLEKDNIIKENTEKSINFLNISNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7P9E6</accession>
    <name>M7P9E6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase EFM4</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFM4</name>
        <name evidence="7" type="ORF">PNEG_01202</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873119.1">
        <property type="nucleotide sequence ID" value="XM_007874928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P9E6"/>
    <dbReference type="STRING" id="1069680.M7P9E6"/>
    <dbReference type="GeneID" id="19894899"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01202"/>
    <dbReference type="eggNOG" id="KOG1271">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044783_1_0_1"/>
    <dbReference type="OMA" id="PTPSFQF"/>
    <dbReference type="OrthoDB" id="10069295at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03188">
        <property type="entry name" value="Methyltr_EFM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026635">
        <property type="entry name" value="Efm4/METTL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843:SF5">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE METTL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Methyltransferase" evidence="6">
        <location>
            <begin position="61"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="224" mass="25750" checksum="9848913E151376B2" modified="2013-05-29" version="1">MSIDELEPSVLGTRKYWDYVFKNERKNFESFKDYGEIWFPFGEDLENKIIDWLKNNISPQPDLKILDIGCGNGHFLCSLSSKGYSSCTLVGIDYSDVAIQLSKTIVNERGIKNITFKTLDILDFEDYFKEKWDVIFDKGTFDSISLNDEIIRDTRACLLYPTCIKKLIKKGGFFIITSCNWTKEELIFKFSSEGLIYHSSIDGPMFSFGGSYGSSFSTIIFTFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M7P9L9</accession>
    <name>M7P9L9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4045 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01271</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873195.1">
        <property type="nucleotide sequence ID" value="XM_007875004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P9L9"/>
    <dbReference type="STRING" id="1069680.M7P9L9"/>
    <dbReference type="GeneID" id="19894968"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01271"/>
    <dbReference type="HOGENOM" id="CLU_502589_0_0_1"/>
    <dbReference type="OrthoDB" id="5412583at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025118">
        <property type="entry name" value="DUF4045"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13254">
        <property type="entry name" value="DUF4045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4045" evidence="3">
        <location>
            <begin position="25"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="518"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="543" mass="60586" checksum="622C578A1523964E" modified="2013-05-29" version="1">MTAQANRCISSTNEHDIDLENWIIRVKKLQEDRNGEDEERDRKLEEEILAERQARHERRAQRELSLSPDRLKPVSCASSRHSICSLSNLFKEKCSTKTDLPNTVCYKDSFEENINKYSKNFSEISEQAYILTDMHTKEDSSSSALGTSADIENNQACNYEALSFQAKESLYASQLRSKDVSYASSILKVKEIDKMEPGVLENKQMPLKNLSNTILSSGNLENCKPVSSQNFIDVSSSPYSSPSLISSYSDTLVSNRLLGSDLPSLSPTKGSFVQSAAMKNNEYRKSVSELSRNSSILSRKSAKLNSEILIKMSGVQKIKLNDEINSLENDAIFSTKDNIILNSDYKLNLKESCNTLENTKTNMENMSFSGDLNVLDPLKKKGSDDSLKPASLEFKKLNTSPTSFHEFQNVSSKVKNNFSSQFSTPKSSIIEGSPDFSDFSKGKYSSSASFSNSSKMDSFKAGILDAKNNLRPSFRTSSPKYDPFKDDILNAKESLKSFSASPREKSDIFKERLLEARSSLGKPGSSSCKSSIEDSLPLRFKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAC3</accession>
    <name>M7PAC3_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00928</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872840.1">
        <property type="nucleotide sequence ID" value="XM_007874649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PAC3"/>
    <dbReference type="GeneID" id="19894626"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00928"/>
    <dbReference type="eggNOG" id="ENOG502S5M9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073624_2_1_1"/>
    <dbReference type="OMA" id="KLTICKE"/>
    <dbReference type="OrthoDB" id="2142503at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36854">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36854:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082699" evidence="2">
        <location>
            <begin position="25"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="130" mass="15217" checksum="27CD1B634A5F95E3" modified="2013-05-29" version="1">MKYSKKTFIIYIILIISLFPGIKAIYSYCKCTCFGNSTVLRLSKPTLKNKPCQDCTKKFCLEQNLPICQNVQFKNSEDLMENTDISTICFQRESIKDMTFIYIFIIITGILLILAPLRPYTTQFFKKIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAK4</accession>
    <name>M7PAK4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872939.1">
        <property type="nucleotide sequence ID" value="XM_007874748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PAK4"/>
    <dbReference type="GeneID" id="19894724"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01026"/>
    <dbReference type="HOGENOM" id="CLU_565140_0_0_1"/>
    <dbReference type="OrthoDB" id="5366841at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MSP" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="483" mass="56115" checksum="BA9639716DB64BFA" modified="2013-05-29" version="1">MTLRLSKHTLCFEEYQDRISKTCISVKNLSLKHKVAFNLQTTTASDHYTVYPSTAMLNPNCECEISFEKHPFSLFHENKESNKTIDSFIIQSIQIDDKMNKKITKMKKNDKIIWDFLESEVQKSFKKNKIKTVTLLVSINNKTDLDVSSNLTTKKSNGTKKESYNNITKKINHFSTLPIKFFRNNMFIQNQKEYEYLHQKKTFRSSSETLETIMSSSRKYQMQDNDLKSRKLFKGSCNMTDKHGNPFQNLKNDFFYSTDTFNTYMSDNTTITVVNLGHSHKTYNNETNNTSLSELWSNKDSDDDTDLNYLKVSTDVIEPKKIEGDFNKGIEHLQVWKLIQKQNKTKHPDTSSDKNEFSDNEFIIPSLPLKQNFIASTISIDSSPSLLSLSQRSTESFLSQEIFYTYKSSTCKGIRNDVRKISFNKESLFSHSQKSTYDNSITPDWMNGILNLQKDFQAMIDDFDQKINFDIKDFNLSTISCQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAR7</accession>
    <name>M7PAR7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major surface glycoprotein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00564</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR10960.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613311.1">
        <property type="nucleotide sequence ID" value="XM_019757723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PAR7"/>
    <dbReference type="STRING" id="1069680.M7PAR7"/>
    <dbReference type="GeneID" id="19894262"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00564"/>
    <dbReference type="HOGENOM" id="CLU_1071816_0_0_1"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021041">
        <property type="entry name" value="Maj_surf_glycoprot_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003330">
        <property type="entry name" value="MSG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02349">
        <property type="entry name" value="MSG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12373">
        <property type="entry name" value="Msg2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Major surface glycoprotein 2 C-terminal" evidence="3">
        <location>
            <begin position="967"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="801"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1132"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="73"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="801"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="842"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="912"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="922"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1140"/>
            <end position="1160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10960.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1183" mass="131450" checksum="DA403B6E75FBA5A2" modified="2016-03-16" version="2">MYDYFERIISRSTFDSPSHMLLRDKRWVEEVAQKEAAMAQPVKRQAAGQAAGNDEIKEEQVLGLIVKSDYSDKDKCKKKLEEYCAELKKIDGELKNVDVKVKGLCENKDKKCGDLKNKVDKELTDFKKEVEEALNDITDENCRKCEEKCVLLEEADPSNLEEKCVKLRDRCYRQRRQGVAKEILLRALKEKVNNKDECKKRMKEICQGLSEYSDELVLICFNSDKTCEYLKGSHQDSCKPLETELEDKELVEKCQEYLEKCYFYGSSCSNSKCKESKEKCGKKGIVYEGPKLDFSPVKEKPRFPEKIEVENLYKRLGAKGIIVGRPKYKTLQDLILLLIKRRNGNSPEEKCKKALEDCESFKHLDYELEQLCEDKDKDNKCKELVEVEDRCTNLKLELYLKGLSTEFEESNESKYVSWEYVPKSVTKEDCRKFESECFHLEGVCTNEIGKACENVRVACYKKGQDRVLNRYFQEGLKGLIGDLELATENLEKCQKSVVGNYTKLKEDRRYFTKCHLPTKLCYELLDDVILQSEELEVVLNLRRDFPSKEDCVELKKKCKDLESDSYLNHEKCDTLNRRCEYLKVTEELRKRLLKRGDDALRTQGNCTAVLKKECEELSRRGKDEFSVSCALREETCSFMVEQTENECLFLKNNINNEKILSKIENGKGNETLVEELCTLFDPYCHQYIENCPDRLKKANSAGGKGVCLELEEKCKPFFEKLKLENELTHELKGSLGKDDECKKALGKHCSEQKDPANQKFNSFCNTDKDKGVEEKVCKKLVEKVKRKCPTLEDKLDKEKDELKKKKDEYEKVKQESEKFTKEAKLVLSKPEQDGQDGNAPKPGGPPVQPPVPGGTPGGVPVPAPTLAPPAPVPGGTPGSVPVPAPTLAPGAPGAPGAPGAPGTPGAPGAPGTPGAPAGPAAPSTPPAPAGPAGPAGPAGPSGGTPGAPAGPPAPGGSTPSGTTNTSNVILVRRTFVSGEVSEPEKKAFVATARALELYLELKEKCKGLQGDCGFRKDCPGCEAACKEIDKLCEGIEGLKVTPHHTVISTATQTTTTTATTTTTTTTTTTTTTTTTTTATTTESVDGGKVTEECTLVQTTDTWVTSTSLHTSTLTSTSTVTSTVTLTSMRKCKPTRCTSDSSKETETQKEEEKEEEVKPNEGMKIRVPEMIKIMLLGVIVMGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M7PB69</accession>
    <name>M7PB69_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872632.1">
        <property type="nucleotide sequence ID" value="XM_007874441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PB69"/>
    <dbReference type="GeneID" id="19894429"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00731"/>
    <dbReference type="HOGENOM" id="CLU_1835969_0_0_1"/>
    <dbReference type="OrthoDB" id="3886018at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029167">
        <property type="entry name" value="Mug117"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15474">
        <property type="entry name" value="MU117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="140" mass="16069" checksum="196F7D34FECFA8CD" modified="2013-05-29" version="1">MGFKMYWIYIFIYILPIYSAFFKQNQDEKNNCYGSLMCGPSMTGSCWQAITKYQSNSYYSKYTSRTESDFGLGSGCTVIYTCDSNQYMNVSGKNIKQKAENIIKRCQEDPGIPCGSEYFNTAREKCRVTVNYCAECNDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7PB88</accession>
    <name>M7PB88_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872652.1">
        <property type="nucleotide sequence ID" value="XM_007874461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PB88"/>
    <dbReference type="STRING" id="1069680.M7PB88"/>
    <dbReference type="MEROPS" id="T02.004"/>
    <dbReference type="GeneID" id="19894449"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00751"/>
    <dbReference type="eggNOG" id="KOG1592">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021603_5_0_1"/>
    <dbReference type="OMA" id="RLWCAFT"/>
    <dbReference type="OrthoDB" id="77601at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04514">
        <property type="entry name" value="Taspase1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037464">
        <property type="entry name" value="Taspase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF8">
        <property type="entry name" value="THREONINE ASPARTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="2">
        <location>
            <begin position="176"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR11155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="345" mass="37132" checksum="2F6F15AF1965458A" modified="2013-05-29" version="1">MMGFVVAHIGAGCHNKTHENHYKKLCKRACEEAMKLIRQGGKAIEAVEKAVQLLERNKYTNAGYGSNLTLNGEVECDASIMDGFSGKLAAVGALKKIKHPISVAKALIDTQDDVLSLNRTQPIILVGEGATLWAIQNGITEVDPETLISPRSRILWEKWSKELELAKTLDINSVSDTVGVIAVDKDGILAAGSSSGGIAMKYPGRLGLAAIPLAGTWVEMNENGTGVAVVCSGSGEQIISTSLAKKCCERILMGEDLLKSVKNCIKNDFLSSRTIRGHTPFAGLVVVKIESLENTYIIDFLFAHCTPSMGVGYMFSNDTKSKAEISENEKSPNSFVYSGNSRSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7PBN8</accession>
    <name>M7PBN8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerases I, II, and III subunit RPABC3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_00305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the eukaryotic RPB8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872177.1">
        <property type="nucleotide sequence ID" value="XM_007873986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PBN8"/>
    <dbReference type="STRING" id="1069680.M7PBN8"/>
    <dbReference type="GeneID" id="19894003"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00305"/>
    <dbReference type="eggNOG" id="KOG3400">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103864_1_1_1"/>
    <dbReference type="OMA" id="IKQYEYV"/>
    <dbReference type="OrthoDB" id="20018at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005570">
        <property type="entry name" value="RPABC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03870">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000779">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00658">
        <property type="entry name" value="RPOL8c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR11275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="125" mass="14448" checksum="D6481B26D6FF4400" modified="2013-05-29" version="1">MSTEMVLIDEIFHINTVDSEKFDRVSRITAISSSQDMELTLDINSELYPLKPNESISVQVASTLHDSFKDSADYIMYGKVYRFDEGEKDLVSVYISFGGLLMCLEGPYKKLNRLSYDHVYLFIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7PC21</accession>
    <name>M7PC21_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00455</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat WDR59 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872336.1">
        <property type="nucleotide sequence ID" value="XM_007874145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PC21"/>
    <dbReference type="STRING" id="1069680.M7PC21"/>
    <dbReference type="GeneID" id="19894153"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00455"/>
    <dbReference type="eggNOG" id="KOG0309">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001497_3_0_1"/>
    <dbReference type="OMA" id="HRRETCL"/>
    <dbReference type="OrthoDB" id="311712at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061700">
        <property type="term" value="C:GATOR2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16488">
        <property type="entry name" value="mRING-H2-C3H3C2_Mio-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049567">
        <property type="entry name" value="WDR59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049566">
        <property type="entry name" value="WDR59_RTC1-like_RING_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17120">
        <property type="entry name" value="zf-RING_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="104"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="RWD" evidence="5">
        <location>
            <begin position="454"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR11435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1186" mass="138444" checksum="C7C6CA70F78EBF67" modified="2013-05-29" version="1">MKAINSPTLDKQMSIEVDEPVGSMSISACGRDVILGSRKGLLIIDIDNPYDPPRFLPHLTTWEVADVQSSPHASRSFWIASTSNQKTIVWNLLLPSRNAIEFVLHSHSRAITDINWSTHHPDILATCSIDSYIHCWDLRDTKKPINSYCDWTAGSTQVKWNNQNQHILASSHGQFLRIWDDRYGAQPFKSIRVCEYSTKIYGIDFNRTKETKIITCSLDKSVCFWDYEKNENIPERIIRTNTPVWRARHTPFGWGIITMPQRDDNSLYLWDIQDENSAPVEPSAKFEGHTDIVKEFVWRYSETDDISKDTRRFQLITWSKDHHLRLWPISNEILKSTGHNPEKPVRFRMTHLGTEYKTYRHEPFIDQKDTSSLHIPISPQTKSTLRSSINNKTNTLFNRYKTVTGNHIHGEYMTKSIRSFKGVQPLAWMRGVHIERSINSNSAITWNIPENLGEELSWIGQKFPKVNFEEINVAGRKCTLTLNGPWGIDNTMIFIRLLVQFPFNYPNSATPDFELEKTLSLSEENYIEIKQSLNKISESYLKKKTPCLEICIRYLLGESVLSGKWISDSEGDSSSDDDQMFSLSGSIFLEKNVNNIVVPTPRKCAATFCFGKLVCFFQKKNESINRIISIFSEKENKTFESPNHYFESFGNIESFINNKIGISSEDLLLKYNSLNLDEETQTNTSLWRSRSFKRKNLKFYSYNNQNERYFNRRASNIRSEDYHGNILIQNISYLEPIKETLARSYKICGPSLEVCEHNAKIALKYDLLELYEVWTLIKMIISGVELRTYTNLFTNKDKTDTNLKLFIYKKEQEISNFRKPMQKEPSVYNKIRWDNHPFGQWLIDQIFSYYESLRDVQTLAMLSCVLDSVESSIFQTSVADTDLNEKIYSSSIPQNSHKISNKNNNLHNNVTSILEKCYNHDSFFENTRISQKHFFDHYLTYIKRNDSSDHETIPFEITLPISTEDRKSEHSQLHINQNHSLSVKMFNYQQLDDELIPFSFFSEERRHLKKFYRINYAEFLFRWKLYKKRAEILKFNSRSNNNETFFTTKKDTFVSDNKSVDCIKCSSDQSSLDKNYIICKQAIFFSNCIFCEVYVKGLVSGCIICSHGGHAKCMKNWFMQTKECPTGCGCECLLWTISKEESHDINLQNFQQSENFPKENDIKEIWCKPHNITIFKSKKLQSRHID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7PC58</accession>
    <name>M7PC58_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycogen debranching enzyme</fullName>
            <ecNumber evidence="5">2.4.1.25</ecNumber>
            <ecNumber evidence="6">3.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glycogen debrancher</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PNEG_00495</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of (1-&gt;6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin.</text>
            <dbReference type="EC" id="3.2.1.33"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the glycogen debranching enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="5"/>
    <dbReference type="EC" id="3.2.1.33" evidence="6"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872381.1">
        <property type="nucleotide sequence ID" value="XM_007874190.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7PC58"/>
    <dbReference type="GeneID" id="19894193"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00495"/>
    <dbReference type="eggNOG" id="KOG3625">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001517_2_0_1"/>
    <dbReference type="OMA" id="YEEGHVH"/>
    <dbReference type="OrthoDB" id="10248904at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004135">
        <property type="term" value="F:amylo-alpha-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11327">
        <property type="entry name" value="AmyAc_Glg_debranch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000070">
        <property type="entry name" value="GDB1p Glycogen debranching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000039">
        <property type="entry name" value="Glycogen debranching enzyme Gdb1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000242">
        <property type="entry name" value="Glycogen debranching enzyme Gdb1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010401">
        <property type="entry name" value="AGL/Gdb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032788">
        <property type="entry name" value="AGL_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029436">
        <property type="entry name" value="AGL_euk_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032792">
        <property type="entry name" value="AGL_glucanoTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006421">
        <property type="entry name" value="Glycogen_debranch_met"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01531">
        <property type="entry name" value="glyc_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569:SF2">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14701">
        <property type="entry name" value="hDGE_amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14702">
        <property type="entry name" value="hGDE_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14699">
        <property type="entry name" value="hGDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Eukaryotic glycogen debranching enzyme N-terminal" evidence="18">
        <location>
            <begin position="35"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme glucanotransferase" evidence="19">
        <location>
            <begin position="134"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme central" evidence="20">
        <location>
            <begin position="722"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme C-terminal" evidence="17">
        <location>
            <begin position="1051"/>
            <end position="1504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF14699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF14701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF14702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EMR11480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1516" mass="175637" checksum="C19DBE4D70FAEF7B" modified="2013-05-29" version="1">MTRTQIYSVKLSSTGFPLISGKYICLPPPFVPYYLRFETDEISSIYYESVLKHNFPPKGAKFIRDKCYEVPLDINFNSTTKVDILIHTAGSFSYKIEYSQLPPWESKKSDNFVRKSTDEFCFTVSPVLKINDVCIPLNSLVIQSVVSKWMGPISEWDKFMFYIGKKKGYNMIHFTPLQSLGKSNSPYSIYNQLEFSDNLFDIKLISNQKNDIIKKYLRKMEAEWGLLSMTDIVWNHTSCDSKWLQDHPEAGYNLHNSPHLISAYELDTSLLEFSENLGKLGYPTNPNNIDDLLKIIHGVKICVLEKLKLWEFYVIDVEKSIKDTLDSYKQKRIAKLDSRFSIDINWSLKEKVNVFISVSAITNYNVLGERFSKRLIPEIGAAILCKLFGDDVEEQILVEELTKILDEFNLEYYTEYNSDKEIIIDQIYNRLKYLRLDENGPKQGEISQKRPLVETYFSRIKKNDDSLFHHDRNLCLVNNGWVWNASFNDFASQKSKAYLLRQVIVWEDCVKLRYGEKPTDNPYLWDHMTKYTQILAKLFNGFRIDNCHSTPLHVGVYLLDKAREVRSDLYIAAELFTGSEEMDIVYMQKLGISSLIREAMQAWSPNELSSLIYKHSGKPIGSLDSISSKYSFLEKTGKGDKTSNIIYVQGSQIHSLFMDCTHDNEMPSQKRIAQDTLPNAALVAMCNCSIGSVMGYDEIVPHYINIAEETRKYYYSLENTLGIGDVKAVLNRIHVEMGKESFEEMYVYNEGNYITVHTVNPKNYHGYFLLAHTAFFSHHENDKMEPIILRGTKADVIFSLSLTVDSSENLEDPNFIKGFFSTIIELDSPIITVKEDLEGIFTCVETPKEFPPGSIFLLKTWVENVDEKLDDFICSDAYKAMENLDLIDLNAVMYRCNQEEYDTINNGTYNIPGFGNLVYCGFEGWMALFKEIIQNNNLDHPLCKHLRQGQWALDYVVQRLYKMGNILSRLQLPAIWLQKRFSRIKKVPSFLLPRYFITIVYLVSMAARNRAISLMSLHVQNGHSFIKSLALCSVQLQGIVKSASLDPFVNTPCVAAGLPHFSCDWKRCWGRDIFISLRGLFLVTGRFDDAKRHILAFASVLRHGMIPNLLDSLKRPRYNSRDSVWFFLQAIQEYTKLVPNGIQILYERVKRRFPMDDSYVELDDYRAYSYESSILEIVHEIMQRHASGLHFREANAGMDLDMQMTDKGFNIDIYVDWKTGLIFGGSQYNCGTWMDKMGESLRAGNKGVPGTPRDGAAIEISGMLKSTLRWINELRKKNIYLWDCVVIQENGYSKNVTFEEWEKKIQENFEFCYYIPLDPQEDFKYDLNTSMINRRGIYKDLYHSSKEYEDYQLRPNFAVAMVVAPELFVPGHAFKTIEIADSVIRGPMGMSTLDPSDKDYHPYYINFYDSDDFATSKGRNYHQGPEWVWCTGYFLRAFLYFNTFYYYSIKNKITTCYYIHDRLAILMKRIQENPWAGLDELTNKSGEFCIDSNYTQSWSVSTMLDLYDDILKLRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7PC71</accession>
    <name>M7PC71_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_03514</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875606.1">
        <property type="nucleotide sequence ID" value="XM_007877415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PC71"/>
    <dbReference type="STRING" id="1069680.M7PC71"/>
    <dbReference type="GeneID" id="19897201"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03514"/>
    <dbReference type="eggNOG" id="KOG2543">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028223_2_0_1"/>
    <dbReference type="OMA" id="QLRRWHG"/>
    <dbReference type="OrthoDB" id="365981at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020796">
        <property type="entry name" value="ORC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047088">
        <property type="entry name" value="ORC5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048866">
        <property type="entry name" value="ORC5_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14630">
        <property type="entry name" value="ORC5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21639">
        <property type="entry name" value="ORC5_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="7">
        <location>
            <begin position="10"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="ORC5 lid" evidence="9">
        <location>
            <begin position="220"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 5 C-terminal" evidence="8">
        <location>
            <begin position="311"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="446" mass="51591" checksum="8A8805D0FA251704" modified="2013-05-29" version="1">MNKKDKLKDRFPARTAQIEQLAIFLEEKKLAQIPSLIVHGHRFTGKTSVLRGVLECFEADFVWIDCQDCFSIRILLERTIYQLREIIGKNKQNESLKSDDFVTFTVAIQNLFLKAKWTSNVIVVFDHVEQLQHFKVTIPTIVLLRLAELSFVPYLTTVLITTSLDTLSWGSYHVPTIYFPPYSKSEFIEIMSLHKDSVALLSNTLNFEDEITSADVINLWQKFCKIIWDTFGSVIEGDFDLFFSVSKKLWLIFIEPIKEGKATKKDIIKLYKFSQYASELSSSKAILEELSKLTYHKALIHDFESQSVTDLSWTSKYLIIASFLASYNPPKYDFTLFSKFRDHTKKRKRIKKPTSAIISQRLIGPKSFVLERMLAIFLAIQSNEDILTSDIYTQIENLATLKMLIRTSLTSDKLDSASRWKVNVSWNFVQKIAKSVGFELEDYLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M7PC79</accession>
    <name>M7PC79_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_00518</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872406.1">
        <property type="nucleotide sequence ID" value="XM_007874215.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PC79"/>
    <dbReference type="STRING" id="1069680.M7PC79"/>
    <dbReference type="GeneID" id="19894216"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00518"/>
    <dbReference type="eggNOG" id="KOG0174">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_5_2_1"/>
    <dbReference type="OMA" id="TFIYGYC"/>
    <dbReference type="OrthoDB" id="7854943at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03762">
        <property type="entry name" value="proteasome_beta_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000010">
        <property type="entry name" value="Proteasome subunit beta type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF0">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR11505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="218" mass="23614" checksum="6B65526B2E6FC4EE" modified="2013-05-29" version="1">MLNPRTNINKQKKEEIQLGTTIAAIKFIDGVIIAADSRTTMGQTIVNRVSDKLTKLYGKIWCCRSGSAADTQAISDVLRHHLSLYAIQNNKPPSVEIAANLAAEICYQNKDILTAGLIVAGFDDEKGGDIYSIPLGGSIHQQNIAIGGSGSSYIYGFCDKSFTPDMSKEEGIEFLKQAVSLAIKRDGSSGGVIRMAVITKDGVERLFFSQENNQIPNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCZ6</accession>
    <name>M7PCZ6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_03160</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875222.1">
        <property type="nucleotide sequence ID" value="XM_007877031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCZ6"/>
    <dbReference type="STRING" id="1069680.M7PCZ6"/>
    <dbReference type="GeneID" id="19896847"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03160"/>
    <dbReference type="eggNOG" id="KOG3408">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117291_1_1_1"/>
    <dbReference type="OMA" id="MKDHFRS"/>
    <dbReference type="OrthoDB" id="24683at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000299">
        <property type="entry name" value="Zinc finger protein 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051879">
        <property type="entry name" value="C2H2-ZF_Maturation_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR08319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="113" mass="13565" checksum="C449C2E808905045" modified="2013-05-29" version="1">MGRIRHKRKHTSNGRHRMYRTRRYQRDIDQIHKDIMIPESRKTLLFKKIDPDLPGLGQHYCIECSRYFETNNTLVKHRTGKLHKKRVKLLKEVPYSQEEAEAAVGIDIKNHIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7PD43</accession>
    <name>M7PD43_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_03214</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875277.1">
        <property type="nucleotide sequence ID" value="XM_007877086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PD43"/>
    <dbReference type="STRING" id="1069680.M7PD43"/>
    <dbReference type="GeneID" id="19896901"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03214"/>
    <dbReference type="eggNOG" id="KOG0126">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045495_3_2_1"/>
    <dbReference type="OMA" id="PMEQFIK"/>
    <dbReference type="OrthoDB" id="2573941at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12411">
        <property type="entry name" value="RRM_ist3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000609">
        <property type="entry name" value="U2 snRNP component IST3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051847">
        <property type="entry name" value="RNA_proc/Spliceosome_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045844">
        <property type="entry name" value="RRM_Ist3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880:SF1">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="31"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="141"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="211" mass="24257" checksum="55BA5A78C6BFB1EB" modified="2013-05-29" version="1">MNIVREITRINAAQIGASESESWHAQYKDSAYIYIGGLPYELTEGDIICIFSQYGEPLDINLVRDKKTGKSKGFCFLKYEDQRSTILAVDNMSGAKVLGRTLRVDHVLNYRHPKQNSDDEESGKLGMNAAPPILYQDIQKTKKESDEEDYGKGIDIDDPMRSYIIKKRKRESKKAKKSKKKSHSDEENQSNHGNHRKNHEKSKYEKDKNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7PD74</accession>
    <name>M7PD74_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_00259</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="10"/>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872130.1">
        <property type="nucleotide sequence ID" value="XM_007873939.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7PD74"/>
    <dbReference type="GeneID" id="19893957"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00259"/>
    <dbReference type="eggNOG" id="KOG1140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GEASYMC"/>
    <dbReference type="OrthoDB" id="26387at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16482">
        <property type="entry name" value="RING-H2_UBR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19673">
        <property type="entry name" value="UBR-box_UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase UBR2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="11">
        <location>
            <begin position="116"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="9">
        <location>
            <begin position="116"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR11835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="2024" mass="234271" checksum="10496AB816759517" modified="2013-05-29" version="1">MNKNSPEKMSPEKRLSIYLLEMPYAFRYTWNLRAKNSLLHELFCAMTGYNQCLETFFFKKGIPGIEKNPTVQKDPDFYKFTSMIEDDSDNEDKIIRINRENMEEKELSSKTSQYKGPCGHVFKKEEALYHCRNCALDDTCVLCSKCFRLSDHEGHDTMMSLNTRGGGCCDCGDPDAWKVDINCSLHSQKTSNYNKLIDKNSELSSIPKELSTYIEMTIERALDYVLDVLSCSPEKPHLLDLQSLKYLERSSRLYSDRYGTEDYPYAIWAVILWNDENHTFQEVIDHVSRVTHRDEEFGKRVANRVDKKGRDTIIVSDNLDLVQNICEKIGQIKLKATIRCARDTFRENMCGAIIEWLKDISLYQIKDNENYMRNIICKLFFESWKKGTCASMNSFFNNHTSNNSYDQLTRELKSEDNETEENMSATIGGNISSMAQKHLSQSSHKIVPESHWIITKSSDVENISAENKYELRIDKLLSFDIKLWKQIRSTLRELYISTMIMSSYYKHSLAIRFSQLYNSLAEEYIFNETEPDQSIINFSVQLFTVPDISLKLVQSYDFLTSLHRFIYTFLTHGHIDISNIIDSKEVLIFNTSNLSKRGYCQIFGDIRYILNTKLVQRIIPTNPKYLLQFIDLLRLFQGMNPCHRVTGAHVEYESESWISAFHLTIEVTKLIKTFSASYKNASASELCNAIGIVMKYLLQWSLGYETERFPTFEPISIHYLNNEISFHSGNTFNVSRDPISFHHPLHWLLISLLENTVILNKSNLLENGYSTILELLSVKFQEVNPKASENMVKKHLIRLIGDYPLSVCTWIDQIRAGLWVRNGISIKGQAHHYHDLSLRDHTYDKDIKWIQLLTVCGADLDDSVLQIIRQYDIISDELIWSLKDAEQHPYYDKSQYFFMFESLLSLFITLFSERSTTLSHDINESTKKELSQVLCFGPLAYSEIIKKIPENLYNNENFNDILVSLCIYRPPRGLHDQGTYTLKDQYFDLIDPYYYHYSWNQQEEANSILKKRANEKGLCYEKNRISNLKIQPIKDGPFEGLGLFTQTLTFVKLIYLCLLYSIHQDQKPESLIDKAVYLCILSVKQEIIQPHENKSYSFIKFANSNFNKNPFSQDSSKTNTTLICLISNMLKQNDLQFIHDKIHMLLYIIKTSSVSSIDSEEKDFTKDDQNSSILLKKMSLEFEERKKAAKERHTRIMAQFQQQQQSFLEKNSDFDIPEILMSNNNDINQDTTDTKNWQFPSGICIVCQEETNELRLYGSLGMIHQSSLLRMTPLNDFNFIQDVIDLPHDLDKNLDHIRPFGFASKSKKKHNTSEIHKKHETDQDYDITTGFPPDYVFHGLFATSCGHLMHATCFKRFYNSLTLRIHGQLSRNAPEDISKKEYLCPLCKSMGNVFFPIIWKESKKVYPGICKPETSYEEWILNSLKLCLMPFYSNVKNENSRNIQSPQKKPELSETLLNEDLFNDFSQKEKYMNIVQTMQTYTFDSVMKPIASLLKTSLLSPHRNHSIDNFIDPLLSETGLRIPLPFSIQSNFNNEMDILQVMYRLLSEILSINFGNTSSKYTESNIFDLDKLWHLFSYTISGIETIQRGKASILDEIVGSTLVHGIPEQSKILLRIISETIMTYITIGLTSKFQNNIQKEFLKKAKTRIYQLFYGHPIYKNSQIKISGLKPILSEDIFAVLVDSSFCVLPTMAFHVHHLIRICYLAEVTKITVTLLQLSQVIKSNGDWPNNIEDSLVNFKKFVFLCSTKLDSTKNIKYDDIVLLRYKFLIRKYVLIFMRKVAILMFSKFGIAFPSETEAQNHYGHSINDELSRLKKLMNLPTLEEIYSISQGTTKLDLIQQDLIFGWITHFNNLSSNNTLQSAPTLSLNHPAIFELLALPKHLQILLEKSMEIKCLKCNTVPQAPALCLFCGLFICSRSTCCSEGDLGECNIHMQKCGKSIGIYFLIKECAILFIHGSNGSFANAPYLDAHGETDFELRRGRPLHLYQHRYDLGVRNLFLQHSIPSFVARKLESILDTGGWTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7PDC0</accession>
    <name>M7PDC0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B22</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B22 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PNEG_03284</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Mammalian complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875357.1">
        <property type="nucleotide sequence ID" value="XM_007877166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PDC0"/>
    <dbReference type="STRING" id="1069680.M7PDC0"/>
    <dbReference type="GeneID" id="19896971"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03284"/>
    <dbReference type="eggNOG" id="KOG3466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108081_1_2_1"/>
    <dbReference type="OMA" id="KWERNAP"/>
    <dbReference type="OrthoDB" id="13598at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20263">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045292">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033034">
        <property type="entry name" value="NDUFB9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="16">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMR08454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="94" mass="11234" checksum="B86845754D68797A" modified="2013-05-29" version="1">MYRSRALSLYRRSLKLSLDWCVRRDIWRLEALKIRSRFESNKNIHDPRLLLAIFDETEEILKKYRHPDPYIVPTSPGGSKWERNILPSAHVSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7PDF8</accession>
    <name>M7PDF8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NTF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_03320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875396.1">
        <property type="nucleotide sequence ID" value="XM_007877205.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PDF8"/>
    <dbReference type="STRING" id="1069680.M7PDF8"/>
    <dbReference type="GeneID" id="19897007"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03320"/>
    <dbReference type="eggNOG" id="KOG0116">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022209_2_1_1"/>
    <dbReference type="OrthoDB" id="339151at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990861">
        <property type="term" value="C:Ubp3-Bre5 deubiquitination complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000003">
        <property type="entry name" value="Nuclear transport factor 2 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039539">
        <property type="entry name" value="Ras_GTPase_bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693:SF20">
        <property type="entry name" value="AT27578P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="NTF2" evidence="4">
        <location>
            <begin position="9"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="301"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="47022" checksum="05060538066A599E" modified="2013-05-29" version="1">MEKLSLDEIGWFFVQEYYTFLNKEPRRLHCFYTKKSTFVHGNEGEIVKPCSGQQEIHKKILELGFSDCKVLVSNVDSQASASGGIVIQVLGEMSNCDGPSRKFAQTFFLAEQPNGYFVLNDIFRYLKEDIDIELCDGECHSYSLDFRNDMLPSCLEINDKTPLIPEEKFANVSILSHDNNPNFQSNQLCTITEPSQELTSVVSTTDGHHEISYEKPSLASSSEKISSIEHIPGYLQNSTFNTLESQSAMYESSTISRPKTWANLFDKPPIHENKKVSSVVKPIITYPQPTLPLERVPAGSISVFVKNVKDRISEEDLRHALSKFGVVHYIELKREKNCALVYFETAAAVASAIAASSVKINKDTVLIEERRNNYDRSRNINGERRINGREYTKYGDEKRIGNDRRGYLNKDKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7PDR2</accession>
    <name>M7PDR2_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_03085</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875141.1">
        <property type="nucleotide sequence ID" value="XM_007876950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PDR2"/>
    <dbReference type="STRING" id="1069680.M7PDR2"/>
    <dbReference type="GeneID" id="19896772"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03085"/>
    <dbReference type="eggNOG" id="KOG0282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022571_2_1_1"/>
    <dbReference type="OMA" id="TLWHPHE"/>
    <dbReference type="OrthoDB" id="10257301at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000191">
        <property type="entry name" value="mRNA splicing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032847">
        <property type="entry name" value="PRPF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="272"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="316"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="402"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="534"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="567" mass="64886" checksum="F415D271A95564E0" modified="2013-05-29" version="1">MSLVSYISSDESENGEKREEKGSNCTRKIVAAPDVSIQDTKRLRLMQNDFKNGKIMLNIPYEDLSKPIQGPVNPFNGRMLEKKTVITGHAEEQGFSEATFRDQYRTFNAFGYARDPSLQSIGFDGPKAFVGDVELAMKQNGESVLERKFNKQRTKEIKSLREKTGDLGTVYGENTYKGPWAKYVFKETEQTFSPPETDEDEENEMPVSNPIIESQNIDVNTTGIEKTIFHGESMYDYQGRTYMHVPFDLDINLLKEPGQQECFVPKKRIHTWEGHTKTISAARFFPRSGHLILSGSMDSKIKLWDVYHERSLLRTYFGHSTGVRDITFTNDGRKFLSASYDRMIKLWDTETGQCISRFTTGKIPYVVKFNPDDDKQHEFLTGMSDKKIVQFDINSGEIIQEYDHHLGAVNTITFIDENRRFITTSDDKSLRAWEYGIPVPIKYIAEPYMHSLTSVALHPSGKYVACQSLDNQIIVFSVIDKFRQRRQKNFKGHSCAGYALEVNFSPDGRLLCSGDSGGYACFWDWKTCRMYKKFSAHNGPLSTIAFHPQETSKVVTGGWDGMIHYWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7PEP2</accession>
    <name>M7PEP2_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02715</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874740.1">
        <property type="nucleotide sequence ID" value="XM_007876549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PEP2"/>
    <dbReference type="STRING" id="1069680.M7PEP2"/>
    <dbReference type="GeneID" id="19896406"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02715"/>
    <dbReference type="eggNOG" id="KOG3422">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078858_0_0_1"/>
    <dbReference type="OrthoDB" id="268521at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_uL16_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_uL16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220:SF13">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="217" mass="24751" checksum="9E4D6D3EF5581900" modified="2013-05-29" version="1">MSYSFPCIKRDYFCFFPVKKSQFYGSFLPFLIPISFDRYLYNNYVMMRVRNGHQYAPRRTKYKKAHKGRIPVPIGMSIKGTTIMYGDFGMRLKDQGVRFTAKQLQTAEMQIKRVIKPIKGAKIYTRVSTNIAVCIKGNETRMGKGKGSFDHWAARVPVGRVVFEIGGGGISSEVATEALRKAGYKLPGKWEIIKRDMPGRIGLHYAPYKTLPNEVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7PF47</accession>
    <name>M7PF47_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02435</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role as a glucosyl donor in cellular metabolic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="6"/>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874442.1">
        <property type="nucleotide sequence ID" value="XM_007876251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PF47"/>
    <dbReference type="STRING" id="1069680.M7PF47"/>
    <dbReference type="GeneID" id="19896128"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02435"/>
    <dbReference type="eggNOG" id="KOG2638">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KEYCFLS"/>
    <dbReference type="OrthoDB" id="932129at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="515" mass="58511" checksum="EB4CA80148489D1B" modified="2013-05-29" version="1">MEGVQLCNTSVLGKEKELTYERMLSMEFEDTSINISSSSMRNELDKLLGTVKDEERQKFFKMEMDNFFSLFNRYLLNKMKKTLQWERIKIPNNEQVLQYKTIKEADINSARVLLDKLVVLKLNGGLGTTMGCVGPKSIIEVREGHTFLDLSVRQVEYLNKKYNVNVPLVLMNSFNTDEDTTRIIKKYTGQNVDILTFNQSRYPRISKESLLPIPRTYDSCIFEWYPPGHGDLFKALSNSGLLEKLLSRGKEILFVSNIDNLGAVVDLNILQYMVDNKSEYIMELTDKTKADIKGGTIIDYEGSIRLLEIAQVPPQHVEEFKSIEKFKYFNTNNIWLDLSSIKRVLENNELALEIIPNYKILSSDVKGDNDISVIQLETAIGSAIHYFGNSRGINVPRSRFLPVKTCSDLFLVKSDLYSLQHGQLTMDETRFGGVPLIKLGNHFKKVSDFQKRIPYIPKILELDHLTMTGAITLGKNVVLKGTVIIVAGDGQSIDIPNGSILENTVVTGNLRLLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7PFS6</accession>
    <name>M7PFS6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Beta-coat protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_02254</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1 10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasmic vesicle</location>
            <location evidence="10">COPI-coated vesicle membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874243.1">
        <property type="nucleotide sequence ID" value="XM_007876052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PFS6"/>
    <dbReference type="STRING" id="1069680.M7PFS6"/>
    <dbReference type="GeneID" id="19895947"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02254"/>
    <dbReference type="eggNOG" id="KOG1058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006949_0_0_1"/>
    <dbReference type="OMA" id="IYKNFDW"/>
    <dbReference type="OrthoDB" id="10261439at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011710">
        <property type="entry name" value="Coatomer_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016460">
        <property type="entry name" value="COPB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029446">
        <property type="entry name" value="COPB1_appendage_platform_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635:SF0">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07718">
        <property type="entry name" value="Coatamer_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14806">
        <property type="entry name" value="Coatomer_b_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005727">
        <property type="entry name" value="Coatomer_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="11">
        <location>
            <begin position="19"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit C-terminal" evidence="12">
        <location>
            <begin position="670"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit appendage platform" evidence="13">
        <location>
            <begin position="811"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR09294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="942" mass="107285" checksum="677A187E269B4421" modified="2013-05-29" version="1">MTSYTLIYQDNLYDTPTLEQLKMSLESKDDNVKIDAMKTILVIMCNGNDMPQLLMHVIRFIIPSRNKTLKKLLYYYWEICLKHSPDGKMKQEMILACNAIRGDLQHPNEYIRGVTLRFISKLREPDILEPLLPATRSCLEHRHSYVRKNAVIAIFSIYSHFPNLIPDAPDLILSFLAVETDQTCKRNAFISLFGMDHEIATKYLSQQLNTVTSMDELMQLAIIEFIKKDSSLNPNNKMQYLPLVFELLESGTNTIAFEAATTLTSLTNNSDIITAIAQKFIDLIVKEADNNVKFIILEKIDDLKRENGSILDDLVINVLSILTNSDINIRKKVLDTSMEMLSSRNVEDVVLLLKKELIKTVNQEHEENEYLQLLIHSLNTCTTKYPQVLEIVADVLIEFIGKFNNISAIDVVVFAKEVVEKFSIFRKSIIEKILLKLNEIKSGKTFYGILWIIGQYCVDEKDIEKAWEYIRNSIGEIPILASEQKLAEETQDDINQYTHINKESNPLSGFRKVLPDGTYATESVLVSETRIIDRHESMRNFHKTILRSLILDGDYYLASVLSSTLAKLIMHYSEVSKNTSKLNFMLAEGMLIMIGIIRVGQSKYVKVHIDEDSVDQILIYLKSLIEYQKNLTIKDIFLKDTRNAFVKLLSIEENKKKKCDTIKEKDILQPDDAITISLLASKSNIPGIDLTQLEISKAINGEIETNLFSLNSRKILQLTGFSDAIYAEAYMKVNQFDIILDILLVNQLSVTLQNLSIEFATLGDLKIVEHPSIHNLAPYDFLKVQITVRVLSTDTGIIFGNCTYDGVGPQDSNIVIFNDIHINIADYIRPSYCSESLFRRMWTEFEWENKVNISSITKSLKEFLNEIMAKTNMACLSPDTLFKEDCGFLSANLYAKSVFGEDALMNVSIEKQDNGCIVGHIRIRSKTQGIALSIGELINKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7PGL1</accession>
    <name>M7PGL1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bystin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874166.1">
        <property type="nucleotide sequence ID" value="XM_007875975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PGL1"/>
    <dbReference type="STRING" id="1069680.M7PGL1"/>
    <dbReference type="GeneID" id="19895876"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02183"/>
    <dbReference type="eggNOG" id="KOG3871">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029727_0_1_1"/>
    <dbReference type="OMA" id="TKLPVIW"/>
    <dbReference type="OrthoDB" id="2192561at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007955">
        <property type="entry name" value="Bystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821:SF0">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05291">
        <property type="entry name" value="Bystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="45887" checksum="81527662F327DB9A" modified="2013-05-29" version="1">MRIRKYREEKGYKRKKTLDVKLSQKILKIAQKQQEEFDDKYSQNVKDSPLIELEDLEFLSESSVDSDYNQKYSDLEDTDFEEIEIDKSDQDLFDKFLDLEPAFKKTMANQILGKIEECDSSIGLNNKTSCSIFSSLPQKVVDVYTKVGLLLSRYKSGKLPKAFKIIPSLRNWEDILFLTSPNTWSPNACYEATRLFVSNLKSYQFQRFISVILFNKVRQDILEHKKLNYHLYMSLKKSIYKPAAFFKGFLFPICETNCTLKEATIIGSILSKVSIPVLHSAAALLRLSEMDFCGSTSLFIKILLDKKYALPYKVVDALVFHFMRWKSLQRPLVVIEHQSLLAFVQRYKNDLTQDQKDILLDVIKAKGHEKIGPEIRRELINSINRGDISTEFMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7PGW8</accession>
    <name>M7PGW8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein sly1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873865.1">
        <property type="nucleotide sequence ID" value="XM_007875674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PGW8"/>
    <dbReference type="STRING" id="1069680.M7PGW8"/>
    <dbReference type="GeneID" id="19895585"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01891"/>
    <dbReference type="eggNOG" id="KOG1301">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016216_3_1_1"/>
    <dbReference type="OMA" id="VNDLRAW"/>
    <dbReference type="OrthoDB" id="10251230at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035543">
        <property type="term" value="P:positive regulation of SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="641" mass="73336" checksum="F26B480D490BE878" modified="2013-05-29" version="1">MSGPFLPNKTLYNAQMESLIKVLNLNSNDKKEESNNYDESMCLTEEIIWKILIFDKLGQDIISTVLKVNDLRDHGVTLFMQLMSERQPISGVPAIYFIEPTLENIQKISRDLSNNLYDTIYVNFLSSIPRSLLEDFASITSSQNTTEMVSQVYDQYLNFVVLDQDLFSLCLPNTYYTFNHHSVSESAIEEIVDKISTGILSVLITLGVVPIIRCPSNNASEMIAQKLSRRLRDYILNTKSNTVFNSSSSSCYRRPVLIILDRTIDLIPMLSHSWTYQSLINDVFEMKLNRIAVNVIESDKKTTRKNYDIYPHDFFWEKNSNTPFPQVAENIDLELTRYKNDANEISKKTGLDIADFDNSSKSENLKIAMTALPELTSRKQILDMHMNIATALLKAIKERQLDNCYEIEESITRQTKSNILEIINDPQKKAEDKLRIFIIYYLSVENISKVDMFEYEDALKKVNCDLKPLSYIKKVREITKMTTMISPPIQNSGTSSHTGDNLFRGLNSLSSILTEKLKDGAITGGLENLISGVRNFLPSYKDFTITKIVESLMEPTSSNISRTEDYLYFDPQNHQVQQNPIRRQQFNEAIVFMVGGGNYLEYGNLLDWAARYPGTKKRIIYGSSELLSPSAFLNELSRLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7PHR3</accession>
    <name>M7PHR3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01757</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873721.1">
        <property type="nucleotide sequence ID" value="XM_007875530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PHR3"/>
    <dbReference type="STRING" id="1069680.M7PHR3"/>
    <dbReference type="GeneID" id="19895451"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01757"/>
    <dbReference type="eggNOG" id="KOG3295">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075696_1_0_1"/>
    <dbReference type="OMA" id="RQHRANK"/>
    <dbReference type="OrthoDB" id="10264538at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00499">
        <property type="entry name" value="Ribosomal_eL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_eL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018256">
        <property type="entry name" value="Ribosomal_eL13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01104">
        <property type="entry name" value="RIBOSOMAL_L13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="197" mass="23326" checksum="C4DAD9F1D3A23792" modified="2013-05-29" version="1">MSIKHNNMLPNQHFRKHWQKRVRTWFNQPGRKLRRRKARQEKAARLAPRPVGMLRPTVFAPTVKYNYKLRLGRGFTFEELKAAGISKRYAATIGISVDHRRRNRCLESLERNVKRLMLYKTHLIVFPRKTKKTKKSDTMDVCNKKYSQVPIDTIIPSFDTKTQVESRIITEEERSFDAFATLRKARKEAKLVGKRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7PI00</accession>
    <name>M7PI00_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI mannosyltransferase 2</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_01844</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873816.1">
        <property type="nucleotide sequence ID" value="XM_007875625.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PI00"/>
    <dbReference type="STRING" id="1069680.M7PI00"/>
    <dbReference type="GeneID" id="19895538"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01844"/>
    <dbReference type="eggNOG" id="KOG2647">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029048_3_1_1"/>
    <dbReference type="OMA" id="GALFIWC"/>
    <dbReference type="OrthoDB" id="10252502at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468:SF2">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR10094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="393" mass="46464" checksum="988EB6461FF87100" modified="2013-05-29" version="1">MKLRDLLVLTVIFLGYKAIFIFICTLSSFLNVYDTSTLFVLKQPENILQRIITSLVRWDNIYFITLAHRGLLFEQEWAFGPGFPYLVRLFTDSIFLDKSLYNYALVSIIISHLFHFFSIFILYHLTFKIYKSRDMAIVTSLLYLISPSGIFLSAGYSESLFSFVTFLGFIFFEEGYNFLAALTWCIASTIRSNGILWSIFFLNSVFVYIYKFLKSPRFCLFFKIVKFGIYSTIVCTGFFWIQYHAYIKFCRKKKQRNWCFKRIPSIYSFVQSYYWNIGFFKYFTVPQIPNFILAFPSIYLSIRSGTYFLMSKNRVQKFTGKLDLYYIAQLLLTILCICVMHIQVFTRMISCLPGIYWWLANYLLNDKPIYWVKVWVLYGMVQAVLFGAFLPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7PI82</accession>
    <name>M7PI82_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Meiotic recombination protein dmc1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_01443</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RecA family. DMC1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873383.1">
        <property type="nucleotide sequence ID" value="XM_007875192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PI82"/>
    <dbReference type="STRING" id="1069680.M7PI82"/>
    <dbReference type="GeneID" id="19895140"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01443"/>
    <dbReference type="eggNOG" id="KOG1434">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041732_0_0_1"/>
    <dbReference type="OMA" id="ANPMKPV"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905334">
        <property type="term" value="F:Swi5-Sfr1 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006311">
        <property type="term" value="P:meiotic gene conversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010774">
        <property type="term" value="P:meiotic strand invasion involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19514">
        <property type="entry name" value="DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000239">
        <property type="entry name" value="Meiotic recombination protein DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011940">
        <property type="entry name" value="Dmc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02238">
        <property type="entry name" value="recomb_DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF30">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN DMC1_LIM15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="10">
        <location>
            <begin position="95"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="11">
        <location>
            <begin position="274"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR10169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="336" mass="37208" checksum="B64427EC3B593E80" modified="2013-05-29" version="1">MAVKEDDSDLSVDEEEQQYIDSDELQSHGIGVADIQKLKSAGYCTVMSIQMATRRNLSKIKGFSEAKVEKLKEIAQKLCPPPFQTAMEVSSFRRRVNYISTGSKQFDAMLGGGIQSMSITEVFGEFRCGKTQISHTMCVTCQLPKEMGGAEGKAAYLDTEGTFRPDRIKSIAARFGVDAEQAMNNILVGRAFNSEHQMDLINKMCTIFSEDGRYRLLIVDSIMALFRVDYSGRGELSERQQKLNIMLSRLTRIAEEYNIAVFLTNQVQADPGATLMFASNDRKPVGGHVLAHASATRILLRKGRGEERVAKIQDSPDMPEGECVYTIKAGGIDDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7PIB1</accession>
    <name>M7PIB1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01472</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873411.1">
        <property type="nucleotide sequence ID" value="XM_007875220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PIB1"/>
    <dbReference type="STRING" id="1069680.M7PIB1"/>
    <dbReference type="GeneID" id="19895168"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01472"/>
    <dbReference type="eggNOG" id="KOG3801">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120076_3_0_1"/>
    <dbReference type="OMA" id="YTTDKLV"/>
    <dbReference type="OrthoDB" id="275715at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20264">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045297">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051522">
        <property type="entry name" value="ISC_assembly_LYR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166:SF7">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166">
        <property type="entry name" value="PROTEIN C6ORF149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="2">
        <location>
            <begin position="5"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="101" mass="12094" checksum="5D20997C8D1D7A1C" modified="2013-05-29" version="1">MVRDQIISLYRSLLRNAKGLENYGFREYAIRRTKDAFQQHKNESDKQKIEELLQKGLRELRVLRRQSLIHYMYPSEQLIIETKSEGKKIRNINSEDVKKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJL9</accession>
    <name>M7PJL9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dilute domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01353</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873283.1">
        <property type="nucleotide sequence ID" value="XM_007875092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJL9"/>
    <dbReference type="STRING" id="1069680.M7PJL9"/>
    <dbReference type="GeneID" id="19895050"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01353"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007327_0_0_1"/>
    <dbReference type="OMA" id="YAKDWNL"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15473">
        <property type="entry name" value="Myo5p-like_CBD_DIL_ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037986">
        <property type="entry name" value="Myo5p-like_CBD_DIL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052072">
        <property type="entry name" value="Vascular_dev_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027:SF6">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="158"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="3">
        <location>
            <begin position="345"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="729"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="761" mass="87835" checksum="62C5186ECE6B9A87" modified="2013-05-29" version="1">MEELKSCTNDSQNDIEDPFTVNDIDSTQSLDFHPAEDREWPWMDPWMGKNEEPLEASLKNYNVDETTHSADASIIAEDTLTEEEKKGILQSSFIRAASHGDVERIESMLKGESRKYIDIDGCDETGGTAIIFAACFGHQGVVEALLEAGANINVRDKAKWSPLMWAINNHHGGIVKLLLAHGASFNARTIGGNSVLDVSSQIDMIDILQALHVEESLEDGESFEDHEWYHQGCLEQIEKEKMTEMPTLYDLEVDLSSIGLETSSKELDDIEEVFSEEDFVWNKCLPEQMYVFSEDHISCILDLVITNFEPLRSRDQKVIPADVIFLSIRFAHYYGTKDMLNKLLCDTLNRIRVLIHDKPDDMAILAFWISNCMLLLYYIKKDSGLLVTIIDFQLQLTELIHDIYLAFLQETKFRIEKHLNNSILDYETISTFDKVAFENKWYTFWRQKKKNSVYFSPEKHATPSPLLITILFSSIFFILDVYHVHFVIFKQVVNQIFYWFNAELFNRIITKKGYLSRSKAVNIRLNISVIEDWARVNNCQFQKKMHIKSLNSRYKSFDIYDSFKSHIAPLVQLLQWLQCLTSLNSIENIETTVDTLNLLTSTQLLYIVKNYKLEIDENKIGKEIIQYLSRKEEKDKDIKKESIQDSENYFTNDTFDNPKPPSFDKGKFRSSNLLMNVDLMLPFILPTGTDLLASYGSKIIKVDKKKKRCFIPVIPSDFMDLLKTKVDHGNKKEQTGTNNEELDDEEIQSAGDNDLSENFKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7PK38</accession>
    <name>M7PK38_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ras-related protein Rab-4B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00946</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872859.1">
        <property type="nucleotide sequence ID" value="XM_007874668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PK38"/>
    <dbReference type="STRING" id="1069680.M7PK38"/>
    <dbReference type="GeneID" id="19894644"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00946"/>
    <dbReference type="eggNOG" id="KOG0086">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_23_1_1"/>
    <dbReference type="OMA" id="ASQNICI"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001072">
        <property type="entry name" value="Rab family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="30807" checksum="24BD0C1A3754FBFB" modified="2013-05-29" version="1">MRWKRIQSISSSVSSTYDYENEQELENMYDYLIKLIIIGPSGSGKTCMLHRFVKNEFRTLSSHTIGVEFSSKVVKLGVGARKKRIKLQLWDTAGQERFRSVTRSYYQAAAGALLVYDITNHDSFTSLPSWLRDTRALASPDVVVVLIGNKSDRNREREVTVNEAMGYANREGLSMLEVSALTPHLIDDAFLLVARQILGKIELGHIDPNLPQFGIQYGDDGMYDWPTRGSLRGTFMWRKDYMRWSECLRNVIKKDDNISDSSQRWSCLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M7PK88</accession>
    <name>M7PK88_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872924.1">
        <property type="nucleotide sequence ID" value="XM_007874733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PK88"/>
    <dbReference type="GeneID" id="19894708"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01010"/>
    <dbReference type="HOGENOM" id="CLU_765298_0_0_1"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="362" mass="42933" checksum="D590132CED17B16A" modified="2013-05-29" version="1">MKVPSKLQIALAIVICRSKQPYLTIEEYIDYIREVLYRRNRKKEVKEICECSNTVSFWKNMFESMDRENVKLRIKIMELEKGLNKEDVLNKVKEGSKNECFDSEMSRYLCDMEKIDVLQHDSGSEKLYDSFRLFYLSCLRLKSPIIGTLDFRSTSVFETFQRLCKILSSYITDSISMALNNRRINAFRTILEYIAHAVKFSWDDESYYINSFSSVFDALFELIRYQSSYYLTISSKNLISSGILDKNSYVDERYEIVCLISNITNQFYTLFPIVVDLLVKHIKISYTRCQDRDMRLAIRNSENSACGYYLYNLSVLCRKNRRISPDNLEQLIRLVEGNFRDFRCFELDKLLWNSICYLSFME</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7PKJ6</accession>
    <name>M7PKJ6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Rad21/Rec8-like protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00582</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR10979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872477.1">
        <property type="nucleotide sequence ID" value="XM_007874286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PKJ6"/>
    <dbReference type="STRING" id="1069680.M7PKJ6"/>
    <dbReference type="GeneID" id="19894280"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00582"/>
    <dbReference type="eggNOG" id="KOG1213">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025342_0_0_1"/>
    <dbReference type="OMA" id="QQCHYVL"/>
    <dbReference type="OrthoDB" id="5427633at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21789">
        <property type="entry name" value="Rad21_Rec8_M_SpRec8p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF72">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN REC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="5">
        <location>
            <begin position="592"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="308"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="635" mass="72573" checksum="962E0A0242F6BFD3" modified="2013-05-29" version="1">MFYSQEILTRRKGGLGVIWLAATLGSKSSFKKLQRKEILSVNVPKACEYLSEPPEPLALRLSSNLMMGVTRIFDQQYGFFYTDVQLTHAKIRKELATISLEKANIDLPKTKTRTDLFTLVDDPGFMPDLNEYGMETLTLPWHPETSFDIEIGVQESHSSSFDLSTTPVSFSQHTLPRSSLSMNNHTSKLDFSGSISRSAINMSGLIERDTDILGSMNGELSFDFEFDAEGEIRKIEGKQSDISSSIQKKRNDVYKIDSDEGEETVRFQHAEAKRRKKFNHTFEKTLMAYEEVDESMIGELAETDFFDSRDPSFVPQNRNHETSSNTYEDDDQQRKKRKFLGMKTDIRTELPSEDLISWRDDYIKNMEKQSAIKTRKLQEKAALNNVHFFVWSFSEELMHPSLKAMFLDNQKQKYSLKHKKRTKNELNDEPADNIDSLNHQQTEKMPASMNSYFEEEIELGRHIDEELTRRTSSLMPWNQSHISSRPGSVGPGMASISFDTPSVSATGHFSSTIRKNKLIASPLADTLEDVNINIGEDIMEDFEIFEATNLDTQTILQDSQSTIMEKESYNFLEYTQARIHQKEGYTITFEELVPTSNSSRSVASQALCHVLLLASRNILTVHQAKPYEDICIKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>M7PKS6</accession>
    <name>M7PKS6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="17">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PNEG_00666</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="17"/>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872566.1">
        <property type="nucleotide sequence ID" value="XM_007874375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PKS6"/>
    <dbReference type="STRING" id="1069680.M7PKS6"/>
    <dbReference type="GeneID" id="19894364"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00666"/>
    <dbReference type="eggNOG" id="KOG1131">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011312_1_0_1"/>
    <dbReference type="OMA" id="WQTMGIL"/>
    <dbReference type="OrthoDB" id="272481at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000135">
        <property type="entry name" value="DNA repair helicase RAD3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000128">
        <property type="entry name" value="Putative DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000381">
        <property type="entry name" value="TFIIH basal transcription factor complex helicase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 21" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="20">
        <location>
            <begin position="7"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="248"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EMR11069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="778" mass="90111" checksum="D3E9AD86E5FD155D" modified="2013-05-29" version="1">MKFFIDDLPVLFPYPRIYPEQYSYMCHLKKTLDIGGHCVLEMPSGTGKTISLLSLIISYQKFYPEHRKLIYCSRTMSEIEKVLVELKSLMEFRKNVLGENDKFRALGLTSRKNLCLHSSVKQEKKGTIVDARCRNLTASFVKERRKKGENVNFCVYYENLEFLESHDLIPYGVFTFSDLLKYGEVNKQCPYFTARRAIPICNVVVYSYHYLLDPKISEYISKELSKDCIIVFDEAHNIDNVCIESLSVDITENSLKKVSNSINNLEKKIIDMKKNNSEKLQMEYKKLVEDLKKIDEEREEDVFISNPILPDDLLKEAVPGNIRKAEHFIAFLKRFVEYMKTRMKVLHVVAETPLSFLQHLKELTYIERKPLRFCTERLNSLIRTLELPNIEDYQYLQEIANFATLVSTYEKGFILILEPYETDTAAVPNPVFHFACLDASIAIKPVFNKFKTVIITSGTISPLDMYPKILQFNAVIQESYSISLARNSFLPMIVTRGSNQVAISSKFEVRNDPSIICNYGDILIEFSKITPDGLVAFFPSYLYMESIISQWHTLGILDEIWKYKLILVETPDSQETVLALKTYRTACDNGRGAVLLCVARGKISEGIDFDHHYGRTVIMFGIPYQYTKSRILKARLEFLRDMYHIKENDFLTFDAMRHAAQCLGRVLRGKDDYGVMVLADKRFSRADKRNKLPKWIQEYITGGTSNLSTDMSLAFAEKFLKAMAQPFNIKDQEGISWWDINKLHEYQEKEKIQLQSENNKNLMDINDNISDEIIENIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7PM08</accession>
    <name>M7PM08_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872405.1">
        <property type="nucleotide sequence ID" value="XM_007874214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PM08"/>
    <dbReference type="STRING" id="1069680.M7PM08"/>
    <dbReference type="GeneID" id="19894215"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00517"/>
    <dbReference type="eggNOG" id="KOG4391">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029375_2_0_1"/>
    <dbReference type="OMA" id="QYWTSED"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="78"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR11504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="281" mass="32246" checksum="72A19E93D8DC1110" modified="2013-05-29" version="1">MNLINIGISVFIGIITFTVFSIYYLQFRFIYLSWVPMGSRTRVERPDAYQIPYEEVTLSTPDGISLHAYLLIHNDSRPTLIYFHANAGNMGHRLPIVKRLYYDVQCNVLIFSYRGYGHSTGFPSEKGIKIDSLTVLNYVHQHPVLSKTSIIAYGQSLGGAIAIQSVSACQDKYSALIIENTFLSIPRLILDTMPYMYIIKGLFHQYWSSEKLISSITDIPILFLSGKKDEIVPFDHMYSLYQLSRTKKILKIFQDGKHNDTIIQPGYFETISSFLKQNHLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7PMA6</accession>
    <name>M7PMA6_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871904.1">
        <property type="nucleotide sequence ID" value="XM_007873713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PMA6"/>
    <dbReference type="STRING" id="1069680.M7PMA6"/>
    <dbReference type="GeneID" id="19893748"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00050"/>
    <dbReference type="eggNOG" id="KOG2693">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_547599_0_0_1"/>
    <dbReference type="OrthoDB" id="200954at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950">
        <property type="entry name" value="ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950:SF16">
        <property type="entry name" value="ZINC TRANSPORTER ZIP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR11609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="498" mass="57299" checksum="DC5690B8C5CE3DBD" modified="2013-05-29" version="1">MKDKTFWIRYIFTFSILILIFSCDNVKASRHDWSKREMPRNPKEKDPFSEISLNETIELLINDISSGKFGFLSAGFGNCPFLSECQESRIPYLHLGYDCYTYTMQNISNIFRSCQQLAVFLQLKNFVNYRKDQEPDEPEGNKSEFCQHLCSDSKKCPSYNKDNKLESLKDLVYKFEDHIMECLNIDKKSHNPIYFNIYEKKKGKLLQTFFPFSPTINSILATFYISGPPNFVLMLIPNNINKSLLDILVAFAIGGFFGDIFLHLLPKVFLDKKTNRDFDITFFDNQKNIVLSFFILMGFVCFMLIDKTLRLFIKHDSNHDHNEKYIKDGEDKKHDKPIAVSTSISLKSDNTNDIKKRIVVNDEKKRDSSISSAKVLKPALSGYLNFIADFFHNFTDGLALSTSFYVSPITGMTTTMAIFFHEIPHELGDFAVILHSGFTKYKALSCQFITATGAFLGTFIGILINKFSTNFFNTKTYLFNTSIVLNDLVLSFVIGKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZX19</accession>
    <name>A0A0W4ZX19_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anaphase-promoting complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_04272</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RING-box family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="KTW32919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613389.1">
        <property type="nucleotide sequence ID" value="XM_019757794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZX19"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZX19"/>
    <dbReference type="GeneID" id="30671566"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04272"/>
    <dbReference type="OMA" id="QWRWDTG"/>
    <dbReference type="OrthoDB" id="1681166at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16456">
        <property type="entry name" value="RING-H2_APC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000111">
        <property type="entry name" value="Anaphase-promoting complex subunit 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024991">
        <property type="entry name" value="RING-H2_APC11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12861">
        <property type="entry name" value="zf-ANAPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="35"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KTW32919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="85" mass="9833" checksum="83D56A6BEB7E11C2" modified="2016-03-16" version="1">MKINIKSWHAVASWHWNVPADDVCGICRVPFDGCCPDCKMPGDDCPIVWGKCNHTFHIHCIMKWLNTESSKGQCPMDRRKFEIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZX30</accession>
    <name>A0A0W4ZX30_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_04266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="KTW32929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613398.1">
        <property type="nucleotide sequence ID" value="XM_019757789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZX30"/>
    <dbReference type="GeneID" id="30671561"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04266"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KTW32929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="81" mass="9283" checksum="D27C5FEF2E584CCF" modified="2016-03-16" version="1">MKVDFDASFLGHLKVQFFYLEELINISSRVLPIISAFLVYHIAAKLENKFVKNNINSDEDIVINALSLPIEYIFYINSSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZX32</accession>
    <name>A0A0W4ZX32_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_04268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="KTW32931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613400.1">
        <property type="nucleotide sequence ID" value="XM_019757791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZX32"/>
    <dbReference type="GeneID" id="30671563"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04268"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KTW32931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="77" mass="9513" checksum="C6E28317EE042385" modified="2016-03-16" version="1">MLSIDFLFEFIKNSFSNKLRCNLINFNISDIHEYSFCDYYYKELTIVIKIITKECKIWFVDDFLQIYRIYIFENVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NHM3</accession>
    <name>M7NHM3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_03508</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875600.1">
        <property type="nucleotide sequence ID" value="XM_007877409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NHM3"/>
    <dbReference type="STRING" id="1069680.M7NHM3"/>
    <dbReference type="GeneID" id="19897195"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03508"/>
    <dbReference type="eggNOG" id="KOG0132">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016577_0_0_1"/>
    <dbReference type="OrthoDB" id="79367at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031126">
        <property type="term" value="P:sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16984">
        <property type="entry name" value="CID_Nrd1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000397">
        <property type="entry name" value="RNA binding protein Nrd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048892">
        <property type="entry name" value="Nrd1_Seb1_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF4">
        <property type="entry name" value="PROTEIN CBR-NRD-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21380">
        <property type="entry name" value="Nrd1-Seb1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CID" evidence="8">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="521"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="163"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="413"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="663"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="452"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="679"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="711" mass="77496" checksum="EE63C40DB77EF160" modified="2013-05-29" version="1">MDTFESILQGLWKARPPGVSGSKIHLLTQIAVQHVKDGGRMAMLLYKHFKKTPGSHKLGVLYVLDSVARAYQDLAEENEAVEDGTFSGGLQQLTVLLESLMNDMMFYAPAEHKEKVRKLVDIWERAATFPSELLVKLRSVHFSDEKDREKSINQEDRKKEIKQVDGLAFSDKKSPEKTKSSEDSSSINQSASSTSSSSLILEAILQMAQKMQATQTVQTAETTWNSFQHRMSVGGVPMTGLENSASFGASSSTLSSGSCGLGVTSTMPNDFHPSSSVLSSNSNASNTPVASSMASSLSLSDPRNMYRSVLPFSVPTHGNISSLQPSSDVVQAQQRALLQLLEQQGVSATQIQSIIQYVQSLPPNDTSTGLLPLNNVHPSLQAVEHSQQLPKDIQTAAQHSSILSSHALSLHQYPTGGRNVSTEIPSTTLPRSSTDSQASIRSRSPLKRKGSKEHLSTINRSRDPTKLKSFSRKRNERSLSPSEKCHLPLKTMPSESLSSLPSKLYIRDPSVPEDAVKVLSRTLFVGGVSQSITQEELLRMFSCYGDVQSCIVNYAARHAFIKMYKRKDAEAACAGLETVTYGDTIIRTKWGVGFGPRDCSNYTTGISLIPLRRLTEADRRWCISAGWGGTGGRLLEGGFVMEEPDIEIGAGVSSKLISRRLPLGRSEQKNDGNRLSIPSMPSQAVQPQPSSTLVSPWIGAIRENAASKISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJA4</accession>
    <name>M7NJA4_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874913.1">
        <property type="nucleotide sequence ID" value="XM_007876722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJA4"/>
    <dbReference type="GeneID" id="19896563"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02876"/>
    <dbReference type="eggNOG" id="ENOG502SZRN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_783294_0_0_1"/>
    <dbReference type="OrthoDB" id="5336671at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="354" mass="40000" checksum="3A49749DD559F658" modified="2013-05-29" version="1">MRRKLRQKATSASVQGRMGTAKSSKLKNTHTSSILPSLPRKRGRPSKKQEIKTEEGMIEASKKELKEIQTSKNKENNEKENLTQKQKQIKTPLSHKERGLSVSLVVGKSGIARVVQEEIDVVVSAPQANVRNGTGLMERVLSTQAHGIPYQAEYKRPNDSLAFITNREGYVRVEPLTGVLSPQLPTPMDSDFYMDIKGQEMMNIQSLLSPESQWESSGDDITDEEDIMDARVAMKKLIDKRRTVGLGLDEFLGSDVLNTPSFRVGKRQRKLSCKACHMTFRQLWILHAHEKKCNIKQTPFLSSDYFDDTIEDAISYFHEDTRSEQSISSPILPESIPLSKFIEHSTPRKNILSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NKA2</accession>
    <name>M7NKA2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02834</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874869.1">
        <property type="nucleotide sequence ID" value="XM_007876678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NKA2"/>
    <dbReference type="STRING" id="1069680.M7NKA2"/>
    <dbReference type="GeneID" id="19896523"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02834"/>
    <dbReference type="HOGENOM" id="CLU_1012374_0_0_1"/>
    <dbReference type="OrthoDB" id="2284405at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00120">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945">
        <property type="entry name" value="MADS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945:SF534">
        <property type="entry name" value="MYOCYTE-SPECIFIC ENHANCER FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="6">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="275" mass="32109" checksum="7FAE601FC29164CF" modified="2013-05-29" version="1">MFLDRQYQPLAPKIKSTTLLPYKPCGKGKTKIAMKYREDKRQRQITASKRLPGLMKKAAQYSELTGAKVVVLVRDEQRRVYRYCSEGESNIEKSANRMLTDPAEKIFTTEQFSEYSDFQNENSEKNEISTNNDSNLQKYEKKDIEIKTNEKEPEGNHNNIYEILRLDENDINSTEPLLNSINDNYLQWPITFIKSSTYSDLSPQIHEMKLSGSASSFPYNTLNTVNYNRNTSDTPENFFNYYSNTTEINSGFENQENSFMNSEVLWYPKKLKMFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>M7NKD5</accession>
    <name>M7NKD5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 20">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="14">IMP dehydrogenase</shortName>
            <shortName evidence="14">IMPD</shortName>
            <shortName evidence="14">IMPDH</shortName>
            <ecNumber evidence="14 20">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PNEG_02442</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14 20">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="14">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14 20">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homotetramer. Seems to be able to form heterotetramers composed from more than 1 of the 3 IMPDH gene products (IMD2-4).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14 19">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="14 20"/>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874450.1">
        <property type="nucleotide sequence ID" value="XM_007876259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NKD5"/>
    <dbReference type="STRING" id="1069680.M7NKD5"/>
    <dbReference type="GeneID" id="19896135"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02442"/>
    <dbReference type="eggNOG" id="KOG2550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022552_2_1_1"/>
    <dbReference type="OMA" id="MGYCGAK"/>
    <dbReference type="OrthoDB" id="416622at2759"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000007">
        <property type="entry name" value="Chromosome 19 SCAF14664, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14 20" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="5 14 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14 16" id="KW-0520">NAD</keyword>
    <keyword evidence="9 14 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 14 17" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 14 20" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="21">
        <location>
            <begin position="124"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="21">
        <location>
            <begin position="187"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="14 15">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14 15">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14 16">
        <location>
            <begin position="281"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 16">
        <location>
            <begin position="331"/>
            <end position="333"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14 17">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14 17">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14 17">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="371"/>
            <end position="373"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="394"/>
            <end position="395"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="418"/>
            <end position="422"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00062187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EMR09098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="529" mass="57915" checksum="9AB8E69E3AC7FAA9" modified="2013-05-29" version="1">MEEYNSLCLLEEVEKKLKEYPEKDGLDLNTLISSRHNGGLTYNDMIILPGYIDFEVNSVSLESHITKKIVLKTPFMSSPMDTVTESDMAINMALLGGIGVIHHNCTIEEQTEMVRKVKKFENGFITSPIVLSPNHKVTDVRMIKEELGFSGIPITDTGQLNGKLLGIVTSRDIQFHNNDDSLLLEVMTKDLVTGSEGITLEEANEILRSSKKGKLPIVDKEGNLTALLSRSDLMKNLHFPLASKLPDSKQLICAAAVGTRPDDRIRLKHLVDAGLDIVVLDSSQGNSIYQINMIKWIKKEFPGLEVIAGNVVTREQAANLISAGADALRIGMGSGSICITQEIMAVGRPQATAVYAVSEFASKFGVPTIADGGIENIGHITKALALGASAVMMGNLLAGTAESPGQYYYRDGQRLKSYRGMGSIDAIEHLSGKNKGDNAATSRYFSETDTIRVAQGVSGSVIDKGSLHVYLPYLRTGLQHSLQDIGVQNLTELRQQVRKKNIRFEFRTVASQLEGNVHGLHSYQKKLWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NKV6</accession>
    <name>M7NKV6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleolar protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_02603</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874617.1">
        <property type="nucleotide sequence ID" value="XM_007876426.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NKV6"/>
    <dbReference type="STRING" id="1069680.M7NKV6"/>
    <dbReference type="GeneID" id="19896295"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02603"/>
    <dbReference type="eggNOG" id="KOG1122">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_3_1_1"/>
    <dbReference type="OrthoDB" id="427002at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009383">
        <property type="term" value="F:rRNA (cytosine-C5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1170:FF:000001">
        <property type="entry name" value="Ribosomal RNA methyltransferase Nop2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023273">
        <property type="entry name" value="RCMT_NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054728">
        <property type="entry name" value="RsmB-like_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF30">
        <property type="entry name" value="28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22458">
        <property type="entry name" value="RsmF-B_ferredox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02012">
        <property type="entry name" value="RCMTNOP2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="248"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="465"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="340"/>
            <end position="346"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00082314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR09268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="598" mass="68909" checksum="E2F25A1D16F3D17B" modified="2013-05-29" version="1">METQQHNKQEVPSLKEFIKKHKVQYGHISNKRRFDEKSQMFKRKKAKLKKKTIKIIKETEKNEKSSHNSGKNESKLYLENESSITNFSNDHDNFKNSKDSSISDTDELYCSLGEDNNDSYKEYMFSDCNNKKRSDSDSIISEKMNLVLNTKSNQEKLIDKSINKESSVSLSEDEINQKKQDYDHQFLKTRIQKTIHLLSNFKNFSEKKQSRSEYIEQLLEDICKYYGYSRFLAEKLFNMFNVQEAFEFFEANEVPRPITIRTNTLKTTRRDLVNALMNRGVNLEPIEKWSKVGIQIFESQVPIGATPEYLSGKYTIQTASSFLPIIALSPQVNERILDMSAAPGGKTTHIAALQKNTGVIFANDFSKDRIKSLVANIHRLGVKNTIVCRHDGRDFPKVMGGFDRVLLDSPCSGTGIISKDQSIKIKKTEKDFNILSHLQRQLILSAIDSVDANSKTGGYIVYSTCSVTIDENEMVIDYALKKRPNIKLVDTGLSFGVDGFTRFRDKVFNPKMNLCKRYYPHVHNLDGFFIAKLKKISNKIPQNLNENITNHDKTIPQRLDDNIKFDELDNILIERSRIRLLKKKGIKPRKANKKDKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLA4</accession>
    <name>M7NLA4_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874396.1">
        <property type="nucleotide sequence ID" value="XM_007876205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLA4"/>
    <dbReference type="GeneID" id="19896083"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02390"/>
    <dbReference type="HOGENOM" id="CLU_1090387_0_0_1"/>
    <dbReference type="OrthoDB" id="5411161at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="255" mass="30072" checksum="67659337CFF9514C" modified="2013-05-29" version="1">MASNGSKNVFEGLYHSSKDTIDQIKQAYSSPKECVHSYWCLIPMIFVILFGIFILLVIYYFLMNIIRSCCCCCFLCRPSTYARSQPTVLVQPTVVPQYPVWYPERMDDHQRMDMYYHSLPKHTAKPLPQRSPWRKKELENNKKMHLIFNKKNPENFHYGVNNLESKENFGEFWADFEVESPKENNVLVDSREYLSELSVNSNYSYYGNSNQVSDEDLKSIYYSSNVKSYPDTLDRMENRSYSPDIYNKNRCYSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLJ9</accession>
    <name>M7NLJ9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EDC4-like protein pdc1 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_03512</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875604.1">
        <property type="nucleotide sequence ID" value="XM_007877413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLJ9"/>
    <dbReference type="STRING" id="1069680.M7NLJ9"/>
    <dbReference type="GeneID" id="19897199"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03512"/>
    <dbReference type="eggNOG" id="ENOG502R9YM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_272622_0_0_1"/>
    <dbReference type="OMA" id="KHIIFFD"/>
    <dbReference type="OrthoDB" id="21128at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055393">
        <property type="entry name" value="Beta-prop_EDC4L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24106">
        <property type="entry name" value="Beta-prop_EDC4L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="EDC4-like protein pdc1 beta-propeller" evidence="4">
        <location>
            <begin position="315"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="488"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="151"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="980"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1184" mass="132697" checksum="5226B167577BE6A1" modified="2013-05-29" version="1">MDASRSLLDLLRPNSESKERINQEGGVGTSKGINDVQSNFLSILIGKTGDSVDKNVAGGLKTNFQSEYLSNLIESKNNGILKESGKKERSVSVSERTVTSKGSVIASVGDKSTSAGISTGLPGSPDVSVTSSQSGLLSILLGDSAGGLSETLPTNSRNFKNAPESTGSNTVLTGGSETAPLTIKGPSASGTSTSVSTVSAGATMTDEKTPKAMFSAINIFDQLSVTNPRLSDLKPKKILKAPPRMNDSGSSKIEGESTSLKNTIVAADNFSSQKLTLKKEIELGKTQSIRKILLPRSPFKRILIPLAKNLGYYDKIELTEIARLSVTFDSLNNHTIDANKNYLAYAIPKDGNLRLMNQDDGSHILLSGQPGSKIHDVSFSKYIVNPENVTYLMTTNSKGGVIIWYILKTSFSNPSKSVKMIFRFNGEYSLSNTEIKAKFCPIMNIVAIKLLNRIYFFRFSTDRFEEVQRSEISMSNANIGFVVAEKFIEDFAFSPDGRVLVTIHEDGTAELWSIYEHIENSIKFAISTSILSYAVSNEPLFWVSFIGPKQLNAPSKYLIFGLRCNRKLYLLDLDSGLISQELILTGNSENSNSEVSSIALYDNSSQNLIVNDHSGFLYRFHYNNKDIEVPMSQDSYLQSLVSKNTSVDVSSKNWSLFDSFCIVSFIAKKTLYNFNLVSLNDSTLDLFAAHDKGYTILHFPISKQEIVVDELKESNIYTYTAQSVLITENTDMIAKSVNQNKEFSVEQKVVSDIKFHDGSYDSKQEFVKTIKKKKAKNDEVSSNNKTDVDIIESVDMNSSFSTLNIDDNSCNISDYADLRKFIKILFIEFNKQNKKIAELISQNDEIRASQDKLLFRVSENFNNIKEYIEKNVSLSVKNNILPVISKFASNTTDKQLTQLTPCIKKISQELTTEIYNVCSKFMDKTSLVQDISESLEKVYLKALNSEMDFYVKGNISQLQNVFQKISQMETKYDERLDFMLKQISDERKKQHTNIEMLLNNLLSLEKQLSTLLSKIDTDKLNMNPQNCSSKFLGDSYQSIDGVRAPFRDLLAKSHYNDVLAIWVQSPYKSETFDMFASLDPKVVLDNASYVILFSVANTLSEIIEDIGDPLIEKKLQWLETCFKLLMNMENHYFTGITLQILLLIENRMDNLYERLRHITPKVPYLRIVLSILYFAAELRQFFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLL8</accession>
    <name>M7NLL8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mini-chromosome maintenance complex-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_03474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875563.1">
        <property type="nucleotide sequence ID" value="XM_007877372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLL8"/>
    <dbReference type="STRING" id="1069680.M7NLL8"/>
    <dbReference type="GeneID" id="19897161"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03474"/>
    <dbReference type="eggNOG" id="KOG2545">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_544182_0_0_1"/>
    <dbReference type="OMA" id="EEHTEMI"/>
    <dbReference type="OrthoDB" id="329666at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019140">
        <property type="entry name" value="MCM_complex-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13489">
        <property type="entry name" value="MINI-CHROMOSOME MAINTENANCE COMPLEX-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13489:SF0">
        <property type="entry name" value="MINI-CHROMOSOME MAINTENANCE COMPLEX-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09739">
        <property type="entry name" value="MCM_bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="59971" checksum="6A20AC948AD1C75A" modified="2013-05-29" version="1">MVRSVVDSWLNNPINEICSIFEENYSKKQTLNIFSDFGVQECFLNVFYSNSQREKIPSLESTPRESLHTGRLVRMTCMIQDTSFGQEICMGAYKIEGEGWKLSRYDLLTPERSTLDPSDPTILLDERQCLYATSIPGESEWLQEDLANMLNSLSLDTSSGTCISERFALKDQKHLAVILKTYAGMEASFRVCNLVEVIGILEKDTETVQEFMTNEQYTVKLHLPIIHVIHMNMIDLNELVTRDLGTMKQDDILKTRKDIINHLATIFCNDVLVAEFLLLNLVSSVSSRLPAIILGSFPINIRNCTPTISLKFKEFLKNVIPAFVYEKIDIYNLNNNKFYPSSDGEKLQAGIMQLAKGTIVCFDETSMDEGTLNDTGIKNIRSLSQVVMSQVLPFHFSFSEFEIETDLTIIVLSKNEKTLLPVDTSISIRPQPLSDSTLLLSLTSDKLLQFRKYFAYTRQISVGISNDISEKIQLDFVQQRQFGNKIGEKELGFRISVAKLISKTCGSKSVSWDHWINAVRLTSSIEALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLS5</accession>
    <name>M7NLS5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_03531</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875623.1">
        <property type="nucleotide sequence ID" value="XM_007877432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLS5"/>
    <dbReference type="STRING" id="1069680.M7NLS5"/>
    <dbReference type="GeneID" id="19897218"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03531"/>
    <dbReference type="eggNOG" id="KOG1331">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029501_2_0_1"/>
    <dbReference type="OMA" id="VHEVYQQ"/>
    <dbReference type="OrthoDB" id="271595at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106335">
        <property type="term" value="F:tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051422">
        <property type="entry name" value="AlkB_tRNA_MeTrf/Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069:SF21">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="92"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="282" mass="32263" checksum="940744A399CE7DE5" modified="2013-05-29" version="1">MKDKDDIEQKEKNIKQFKKKHKNKNKTLKTQNNSILHNISTPCHITTSETIETSYVHNVYSAIAGHFSATRQKPWPTIENYLLKQPTGALGLDVGCGNGRYLFLSQNIFLIGIDRCEALLQIAKEAGEAHVILGDARLLPVRPIFDFAISIAVIHHLTIEAHRIDALRQLLTILRPGGTALVSVWALEQPNSRRGWNECSPQDILVPWISYTKAESPDNESRDIDQKDRVVETKIYQRYYHLFRKGELEEYIKKAGGEVIESGFERDNWWAQMQLKVNKTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLT4</accession>
    <name>M7NLT4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major surface glycoprotein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02212</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874195.1">
        <property type="nucleotide sequence ID" value="XM_007876004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLT4"/>
    <dbReference type="STRING" id="1069680.M7NLT4"/>
    <dbReference type="GeneID" id="19895905"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02212"/>
    <dbReference type="HOGENOM" id="CLU_283436_0_0_1"/>
    <dbReference type="OrthoDB" id="10542623at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050972">
        <property type="entry name" value="SDr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403:SF17">
        <property type="entry name" value="RETINITIS PIGMENTOSA 1-LIKE 1 PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403">
        <property type="entry name" value="TOL-PAL SYSTEM PROTEIN TOLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082275" description="Major surface glycoprotein 2 C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="825"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="837"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="966"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1023"/>
            <end position="1056"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1099" mass="124533" checksum="E762C23BE73732F4" modified="2013-05-29" version="1">MFFLRIIFIFIFLKISYAENTDKLSDFEKKYPELYQANPHALKLEALKSGFSGKSVKKGLGVFHIGNLGHYRDHKPVILHVIMGLTVGLAECRGTLAERCKVIKALGNPITQYCNKPYDTCQDYFDARNYLLPMKDQLKNPHAHHDACRTILLNCLFFKHRNYITSDCVPLVALCYLRVRQNFVEAIMTEALRGEINTKGAAAAMKKVCEKIGHESPDLLHLCFKTTVLEKLKRSNKQYIEDVKSRIRTVSTGNCRQVLEECYFNVLDYPDIYQSCRNFRRFCSEIGVVYTPVDSTFDLFQKPLSAEKLLIDTSSKISEDLGLGFSKYVQKKSSNLEIAAYLVNKTWVYDNDCRNKLKELCLHIASLPLTKQLCTLAHDRNSKLCRDFYNSIGTECYSLYYEFKNVGLLYNYTYRLSRDQCSKYVERCLFLREQYAYWNSLDTCANVFSSCYKEDMDFSAKLDLLNRIKDKIVVPKGNTRYFVELLCKSYIVAECSASDLMFKSYALMEACLHPERICRELKNHFSEESRKLENKLRSILKPTYYECKDLGQKCNSGFYFDGDIEAQCNHFKKRCQDKQERLKLINHIVNSSALYLANEVQCRTYFDSFCGANVKQEFKQICNKGANGICPDMIDDSKEHCAHLINHLTSLGISSSSASLPLDYCDSAINYCNSLSKFCTESKRQCDSVISFCTSESKKTDEYGSFIDQYPAAAANATKCKVTLKELCQDSSKKDSYSTLCAYNKDGYTEICKNLRNFIEKACENLRIHLHTYDTNSLNTNKGSAQDRCTYIRNLYFKFKNICLLVDPFYDLSPIITQECKTNISEPALPDKDPQPTSSPQPKPRPRPRPQPQPHPHPKPQPQPTPEPQPQPAPEPRPQPTSKPRPQPTSKPRPQPTPEPRPLPVPGPGPLPVPGPRPQPQPQPQPQPQPQPQPQPQPQPQPQPQPQPQPQPKPQPPSQSTSESASQSKPKPTTQTKPSPRPHPRPVPKPSSIDTGPSKSDSSFIFTVTKTITKISETEKPSTKPSVKPTSTKTTSKPSTKPSTKPSVKPASTKTTSESEKPTLEEVPETKGNGVRVIGFEGLQLLSMIVAIIIGIWIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLU9</accession>
    <name>M7NLU9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">B-related factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_03554</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875647.1">
        <property type="nucleotide sequence ID" value="XM_007877456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLU9"/>
    <dbReference type="STRING" id="1069680.M7NLU9"/>
    <dbReference type="GeneID" id="19897241"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03554"/>
    <dbReference type="eggNOG" id="KOG1598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010293_2_3_1"/>
    <dbReference type="OMA" id="EPPCKVM"/>
    <dbReference type="OrthoDB" id="511529at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000994">
        <property type="term" value="F:RNA polymerase III core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001156">
        <property type="term" value="F:TFIIIC-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001112">
        <property type="term" value="P:DNA-templated transcription open complex formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd20553">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20554">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000002">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000007">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.650">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011665">
        <property type="entry name" value="BRF1_TBP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07741">
        <property type="entry name" value="BRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Cyclin-like" evidence="12">
        <location>
            <begin position="87"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="12">
        <location>
            <begin position="181"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="440"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR08116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="491" mass="55499" checksum="C709EEB7CCFC94E5" modified="2013-05-29" version="1">MSTCSGCGGSNLEADSSSGITYCISCGNVIDENVIVSEITFGEASSGAAIVQGSFVGADQTHARAIGPYRKQNSLESREQTITNGRRRINALAAALHLSERHAETAVRYFTLAVTHNFIQGRRSQYVIASCLYIVCRLERTSHMLIDFSDILQINVFTLGSTFLKLVQILHITLPFADPSLYITRFAALLEFGAETHKVATDAIRLVQRMNRDWMQTGRRPAGICGACLLIAARMNNFRRSVEEIVHIVKVGDLTVRKRLEEFKTTASGDLTVQDFRTIWLEQTHDPPSYLQGRKKERRKKDIETIELLNSHKEYETEALNTVTGNQYSSKKILLPLKLVDSDDLVAELDDNFLKGEMESVLQDRNVQKMSIAIQESKKSSDKCYETLSDMDDDEINQIILSEPEVLAKTQVWMELNREYLAAQEARRLKLESDLKAGIGRQTKKRKKRKPRDSNSINLPSTPVESAKKMLQQRTFSKKINYDALNYLFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLZ8</accession>
    <name>M7NLZ8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_03340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oligoribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875419.1">
        <property type="nucleotide sequence ID" value="XM_007877228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLZ8"/>
    <dbReference type="STRING" id="1069680.M7NLZ8"/>
    <dbReference type="GeneID" id="19897027"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03340"/>
    <dbReference type="eggNOG" id="KOG3242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064761_3_0_1"/>
    <dbReference type="OMA" id="AFFHYRN"/>
    <dbReference type="OrthoDB" id="270189at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000003">
        <property type="entry name" value="Oligoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003765">
        <property type="entry name" value="PRK05359.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046:SF0">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="5">
        <location>
            <begin position="23"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="199" mass="23142" checksum="B1479294884E124F" modified="2013-05-29" version="1">MNCILWKSLTTKSLTTRIMIQNPMIWVDCEMSGLDPEKHELLEIAVLITDGNLNIIESKGFQRVIHHPEHILNSMDSWCRKYHEENGLIQSVLSSSHTLVSTEIELLDYLQKYISKPKVALLAGNSVYVDRAFLSRYIPSVLEYLHYRIIDVSTIKELARCWNYEVFQSAPKKKANHRAMDDILGSIEELKYYKKAWLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMP7</accession>
    <name>M7NMP7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_01716</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873680.1">
        <property type="nucleotide sequence ID" value="XM_007875489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMP7"/>
    <dbReference type="STRING" id="1069680.M7NMP7"/>
    <dbReference type="GeneID" id="19895410"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01716"/>
    <dbReference type="eggNOG" id="KOG1397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008721_2_1_1"/>
    <dbReference type="OMA" id="AVMITCN"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000011">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00846">
        <property type="entry name" value="caca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="84"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="263"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR09958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="414" mass="46545" checksum="B5EC047FA5A7E958" modified="2013-05-29" version="1">MQEVVKKKLLKVFYFKSLYNQENHSQESEESLQTIYNDENNFDKKKEKYLYFIIKVIFMSSYLNILLFFVPLGILYGYFEWNPTLVFIFNFLAIFPLATILSFLTEELSMKVGQTTGSLLNASLGNVVEMIISIIALNKGQLRIVQTSMLGSILSNDLLVLGICFIAGGLHYQEQQFNMTVAQTMSSLMAVATSSLLIPAAFRLSLPGTDETNKNIIILSRGTSIILLIIYFLYLIFQLKTHTEFYETVIEDTHKELIPPIVSAVFLVLVTLLVSLCAEYLIDSIDLFTASYNVNKTFIGLILIPIVGNAAEHATAVIVSVKNKMDLAVGVALGSSMQIALFVTPFLIIIGWVIGQPLTLYFKTFETVIMFVSVFIINYLIQDGKSNWLEGIMLIAVYCIISIAFFLYPEQKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMT0</accession>
    <name>M7NMT0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_03018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875069.1">
        <property type="nucleotide sequence ID" value="XM_007876878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMT0"/>
    <dbReference type="STRING" id="1069680.M7NMT0"/>
    <dbReference type="GeneID" id="19896705"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03018"/>
    <dbReference type="eggNOG" id="ENOG502S0ES">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_411677_0_0_1"/>
    <dbReference type="OrthoDB" id="5338458at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047092">
        <property type="entry name" value="AFUB_07903/YDR124W-like_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021264">
        <property type="entry name" value="AFUB_079030/YDR124W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102:SF1">
        <property type="entry name" value="YDR124W-LIKE HELICAL BUNDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11001">
        <property type="entry name" value="AFUB_07903_YDR124W_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle" evidence="2">
        <location>
            <begin position="219"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="667" mass="75987" checksum="E5164182D15954B4" modified="2013-05-29" version="1">MPRIPVRVEPYSSPSHQNRHFKCKRDRILRALCKSCYINKSNFAILLVNSRGDYETYASEAFQGQLKSWFNQKVLNDAQKLALAYQKSGDTFKDGLAKKNIRNKENIELKDDKMNGICYPGVLSEDDVLGLKCSDSLEKLFEGPSYDKSLMSDIMKSILGVNEFFIPKEKSLSSNTTCDSRDFQKQEDVNKNSLSVEVDTDDKSNEYVSGEVKYRSLVIGNTAEVIAFMESRFKQLQQSVCKIVAKAWIKVIEPKKQTRYPYNRGDKSKPSWWPVNIRHKEPDHLMKSERIGLLLTMLRCSRIPINRLELATAEISAFMPPNKTSLLREIYQVARQEERMRNGEIDKSTEIYITLTAYDLCSNNKTVSSEIDNQFNQHTSSSSAFLPESSIQSHQSHSDEVEPVHNLGVVQKHLCSNRVTNEQDTDLHKDYFPPYTHDSIQVENQIYSGDQNHLSSEYLVLKKHGIEDMSNHTDVYAEKDNNINSQPLGNFSVFKKNMNDSFYSMNSSDFKEGDRSCYPITSMFPLSSDQIFNSSYDLSLLDKSLSMHPKHVLHNYSSSSDSSSNSAISTYSTTDLFSQKNHQHISEMFSPNNSKYCLSYSNMNYSCFPLHPDTFYNDGSSGACFSIPMKTSVDPSDFPDSTAILQIKYGQDKTAKKAKEGFVKDTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN33</accession>
    <name>M7NN33_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutathione synthetase</fullName>
            <shortName evidence="9">GSH-S</shortName>
            <ecNumber evidence="9">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_03012</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9 11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="9"/>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875063.1">
        <property type="nucleotide sequence ID" value="XM_007876872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN33"/>
    <dbReference type="STRING" id="1069680.M7NN33"/>
    <dbReference type="GeneID" id="19896699"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03012"/>
    <dbReference type="eggNOG" id="KOG0021">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025152_2_1_1"/>
    <dbReference type="OMA" id="NGLVMYP"/>
    <dbReference type="OrthoDB" id="2020073at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.50:FF:000002">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01986">
        <property type="entry name" value="glut_syn_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="12">
        <location>
            <begin position="213"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="411"/>
            <end position="414"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR08531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="488" mass="56154" checksum="994BFDA634A74EE7" modified="2013-05-29" version="1">MKTICKNYPPFLDKNQQDFLISELMDYIQVHGINIRITHSEQDKKHFFNHQNVPLTLFPSLFPSIAFKKAKAIQCDFNKLYAFVANDEEFMCQVMENLVNIDDFIKKLWDIHLEVKKKGIVQPISLGIFRSDYLLEATQNSSPQLKQVEFNTIASSMGSFSSKISEMHKYLNSIGAYGSCILKEENFPKNDSIKLLTEGLANANRLYGEKNTKILFIVEPHDSFILDQRCLEYELFQVHGIQAYRVFLHSILDFIELRQNDKALLFKSPNSKIEEISVVYFRTGYSPNHYPSSIEWSARLLIEESRAIKCPTVITQLAGCKKVQQILCKKNIINKFLPENISKSLKETFVSIYALNRDLSGQEAYRLLMNNPQNYILKPQREGGGNNIYGLNIPTFLKTIPESQREQYILMEMIHPLLQTNTIIQNNELHHTNVINELGIYGVILWNKNGEIYHNKESGYLLRTKDKDKNEGGVMIGCSSIDSCVLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNM6</accession>
    <name>M7NNM6_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_02901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874941.1">
        <property type="nucleotide sequence ID" value="XM_007876750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNM6"/>
    <dbReference type="GeneID" id="19896588"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02901"/>
    <dbReference type="HOGENOM" id="CLU_2050622_0_0_1"/>
    <dbReference type="OrthoDB" id="5314331at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="120" mass="13771" checksum="C8F57185E200E59F" modified="2013-05-29" version="1">MSSKPLRRQLFGIRASLIPSVSITNVFGQEASTLYEDIMDPSSFTTLQFLETPVPGTEEHDQKILEKTKQTEALRKIYTSEQFQHKALGEAVRESLKRIIQDLKEDDWMFEAEETNPVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP07</accession>
    <name>M7NP07_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Multiple myeloma tumor-associated protein 2-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01154</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873068.1">
        <property type="nucleotide sequence ID" value="XM_007874877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP07"/>
    <dbReference type="STRING" id="1069680.M7NP07"/>
    <dbReference type="GeneID" id="19894851"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01154"/>
    <dbReference type="eggNOG" id="KOG4520">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061193_3_3_1"/>
    <dbReference type="OrthoDB" id="5390672at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019315">
        <property type="entry name" value="MMTA2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039207">
        <property type="entry name" value="MMTAG2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580:SF0">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10159">
        <property type="entry name" value="MMtag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Multiple myeloma tumor-associated protein 2-like N-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="214" mass="25098" checksum="8CE1B0DB4BCF559C" modified="2013-05-29" version="1">MADLLTGPIREGNRGGHGLFRWENVKEDKYRENYLGHSLRAPVGRWQKGRDLTWYTKNKKEVSTASLSARDEEIKLIKQAEKDALAEALGFKVEKTTESNEISQDIAKAIHRTEREDEDSRIGTAVKAADTVQGIGFQTMTRHYTQQKEKQNVLDTRRLKQNEHLYMARREDEQDLPVRRGSREDAIRSHYQSRYRSRSPSRNCSRYRNYNRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP45</accession>
    <name>M7NP45_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Pyruvate carboxylase</fullName>
            <ecNumber evidence="3 10">6.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PNEG_02661</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>hydrogencarbonate + pyruvate + ATP = oxaloacetate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.1" evidence="3 10"/>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874682.1">
        <property type="nucleotide sequence ID" value="XM_007876491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP45"/>
    <dbReference type="STRING" id="1069680.M7NP45"/>
    <dbReference type="GeneID" id="19896352"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02661"/>
    <dbReference type="eggNOG" id="KOG0369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_0_1_1"/>
    <dbReference type="OMA" id="AEACICY"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004736">
        <property type="term" value="F:pyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07937">
        <property type="entry name" value="DRE_TIM_PC_TC_5S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000018">
        <property type="entry name" value="Biotin carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000033">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000012">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055268">
        <property type="entry name" value="PCB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005930">
        <property type="entry name" value="Pyruv_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006761">
        <property type="entry name" value="PRK09282.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009554">
        <property type="entry name" value="PRK12999.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01235">
        <property type="entry name" value="pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778">
        <property type="entry name" value="PYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778:SF2">
        <property type="entry name" value="PYRUVATE CARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001594">
        <property type="entry name" value="Pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0092">Biotin</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="17">
        <location>
            <begin position="28"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="16">
        <location>
            <begin position="150"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="18">
        <location>
            <begin position="567"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="15">
        <location>
            <begin position="1097"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="576"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="648"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="13">
        <location>
            <position position="744"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="774"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="776"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="909"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="14">
        <location>
            <position position="744"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-biotinyllysine" evidence="14">
        <location>
            <position position="1145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMR08876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1181" mass="131921" checksum="E1EFCE6F77B8DC63" modified="2013-05-29" version="1">MLIDKNIIYNKYFDSNGIIKRSGVDAEDKLKLLVANRSEIATRIFRTAHELSISTLAIYSYEDRFSIHRQKADESCMIGKIGQYTPVSAYLAIDKIIEISKNRGVHMIHPGYGFLSENSEFARKVEEAGIIFIGPTPDVINVLGDKIRARKIAMEHNIPVIPGTYNPISTVKEALEFTKEYGFPVLIKAACGGGGRGIRVLYNEDLFEDYINRAISEAEGAFGNGSIFIEKYLDRAKHIEVQILADNVGNIVHLFERDCSVQRRYQKIVEVAPAKDLDLNVRNAILNDAIKLAKAINYTNAGTVEFLVDFQGKHYFIEVNTRIQVEHTITEEITGIDIVSAQIQIALGATLPQIGLSQDSIYPRGYAIQCRIIAEDPESDFRPEIGKIEAYYPPGGNGVRLDEGNVFAGAFVSPYYDSLLLKCSCNGHTYEIARRKMLQALKEFRIYGIKTNIPFLLRLLNDDIFILGKCWTTFINDTSLFPISSVGNKIQNLLLYIGDVIVNESYIEGQNGEPKLKDEIIFPILKNLENPNETIDITKPCSEGWRKIIIEKGPGEFSRQVRAYPGCLVMDTTWRDAHQSLLATRIRTIDILNIAPHTSYALKNAFSLECWGGATFDVALRFLHENPWDRLRKLRKLVPNIPFQMLLRGSNGLAYSNLPDNAIYFFCKQAKENGIDIFRIFDALNNLENIALGIDAVKKAGGVIEAAICYTGDILNFKKKYDYNYYMSLVDKVVSMGIHILAIKDMAGLLKPQSAKLLVGSIRKKYPDLPIHIHTHDSAGTGVVSMLACAEAGADVIDLCSNSMSGMTSQPSISAFLASVENTPFETGLSAQHVRNIDAYWEQIRLLYSPFDFDLKGPETDIYEHEIPGGQLSNLKFQTAKLNLVSQWEATKKSYIEANFLLGDIIKVTPTSKVVGDLALFMVQNNLTYSDVIEKAEKLDFPASVLDFFQGLMGEPYGGFPEPLRTNVLKNKREKIFGRAGKLLEPIDFTKIRSELISKYGTIDDTDIATYIQFPKVYDEYQKFVKKYGDISILPTYYVMAKPEFGKEFQIEVEGQIHIIKLLAIGPVLKETGSCDVFFELNGQIYPITVTDKKSALKTISRPKADLSKQGDIAAPMSGIVLEIHVQCNSFVKKGDVVAVLSAVKMEIIISSPISGRVDKIMVHQGDIINAGDLIVTIANH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP69</accession>
    <name>M7NP69_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874707.1">
        <property type="nucleotide sequence ID" value="XM_007876516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP69"/>
    <dbReference type="GeneID" id="19896375"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02684"/>
    <dbReference type="HOGENOM" id="CLU_819199_0_0_1"/>
    <dbReference type="OrthoDB" id="5345862at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="163"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="339" mass="40730" checksum="B460C28C4E703DDA" modified="2013-05-29" version="1">MESKEQNEYHSTRELLDYYKSRLFLAEQATYDDIFARLQEIQQGLSRMHSLERSLQEAIEEIETINEKNIELLEILKEVIGENIALRSKVQFVQQKYGYDISNYCKILNNQPKHKQYYETIITLLKNKIEAQKKMPCDYKRMNELIIKCEKLERVVFEGVHEILRERKTRENYEIQVKEAKAKIELQEKELKQRIEEANYTSKIKLDQNTNQIFTLQQQNEELKHKLIESQNKIDNIKKHSYDTIQEFEKQIKQLKKRYLFQNMAIVNNIRRTTKISPELLLEIASLYTKIKSLERMALKFAPLEGYHVNELFSDIELVKKRAQHIENILFDKKKKCKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP76</accession>
    <name>M7NP76_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01224</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873142.1">
        <property type="nucleotide sequence ID" value="XM_007874951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP76"/>
    <dbReference type="STRING" id="1069680.M7NP76"/>
    <dbReference type="GeneID" id="19894921"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01224"/>
    <dbReference type="eggNOG" id="ENOG502S54T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_513991_0_0_1"/>
    <dbReference type="OrthoDB" id="1112565at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="333"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="530" mass="61180" checksum="6C82718D1416F822" modified="2013-05-29" version="1">MEKYNSSENYHKKLSEIPLNIAFNTESKENDKFYKEKTFTTENSLMNNMDFFEKSQEKGIPWLCSSCCETFPSNELMYNTTEKQEAYYCKNCHLHLLSKNKNIYPNEISNNNTTSQHQDKNPQEHREKINHCINILDNLQTELNKQSFSENCPNSIENPDEVSLKDSIKNNYPIIDNLTPKVNISQSCALIPQGSMKNSEMWKLLRKKKRNSLSVRKHIENFVEVKRSHNSFKTNIIDVSSESSNFPDKIEKEETLESKISFITLSEAQTNISQENIPPILPSTKNYKNKLFLSDHIKFENNALSTIDYNSFSEKDTFSRHLKDSLNNDKQQFLCYSCKMNLTGTIIQITKEKKYHENCFKCNICNIFIRKNEYIFYKNNICHEKCMLELKNSFLSNSISPKKALTSNTISNIKPLKNNSSTEAFSVKKKSLPKFGGFDKCASCSESITFLESYPGPNSTKWHKKCLKCSGGCGKNMDSGSLNEIDKDGKMKVYCRFCWDTIKRGKKPIAISLVMSNTLQDFSTLEENRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP90</accession>
    <name>M7NP90_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Histone deacetylase</fullName>
            <ecNumber evidence="2 9">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_02422</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2 9"/>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874428.1">
        <property type="nucleotide sequence ID" value="XM_007876237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP90"/>
    <dbReference type="STRING" id="1069680.M7NP90"/>
    <dbReference type="GeneID" id="19896115"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02422"/>
    <dbReference type="eggNOG" id="KOG1342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007727_7_6_1"/>
    <dbReference type="OMA" id="CYETSIC"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045835">
        <property type="term" value="P:negative regulation of meiotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032874">
        <property type="term" value="P:positive regulation of stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000007">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF36">
        <property type="entry name" value="HISTONE DEACETYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR09077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="380" mass="43078" checksum="79D1C2555E52517F" modified="2013-05-29" version="1">MKPHRLTLTNHLVLGYGLHKYMNIYRPRRATDEELEQFHSSEYIDFLKRVTPENASSFSDISMKFNMGQDCPIFDGVYDFCSIYAGASLDAARKLNQNQTDIAINWSGGLHHAKKFEASGFCYVNDIVLAILSLLRYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYNANLVSPDKSFFPGTGYYNEIGSGKGKYYSLNIPLKDGIDDQSYVMLFRAILEPVINSYRPTAVVLQCGADSLGCDRLGQFNLSIRGHGQCLEFIKSFGLPLLVLGGGGYTVRNVARCWAYETGICLDAELPDTLPSETPYIDYFAPDYTLHPKITSRVENKNNRKYLENLRMHTIEQLRYLNSAPSVMMQEIPNSLLTEDGDINTNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP99</accession>
    <name>M7NP99_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02433</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874439.1">
        <property type="nucleotide sequence ID" value="XM_007876248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP99"/>
    <dbReference type="STRING" id="1069680.M7NP99"/>
    <dbReference type="GeneID" id="19896126"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02433"/>
    <dbReference type="eggNOG" id="KOG3022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024839_0_2_1"/>
    <dbReference type="OMA" id="KMCSEHS"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001278">
        <property type="entry name" value="Iron-sulfur cluster carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961:SF2">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="221" mass="24844" checksum="6F0024CB8EFF347C" modified="2013-05-29" version="1">MRLSGKKIGLLDADLFGPSIPKMFNLSEKPYLSKENQFIPLMNYGVKAMSMGFFIDNDSPIVWRGLMVMKALQQLIYDIDWGKLDLLVIDMPPGTGDTQLTITQHVILDGVIIVSTPQDIALIDAIRCINMFRKMNVNILGIVKNMSVFICPNCNYNSHIFGIDKLNSIAKNMNIEVLADIPLHKKIMQDCENGYPTVAAEPDGSQSLPFRRLADIIWKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPH8</accession>
    <name>M7NPH8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EKC/KEOPS complex subunit GON7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873242.1">
        <property type="nucleotide sequence ID" value="XM_007875051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPH8"/>
    <dbReference type="GeneID" id="19895013"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01316"/>
    <dbReference type="HOGENOM" id="CLU_2590749_0_0_1"/>
    <dbReference type="OrthoDB" id="5380690at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="9683" checksum="9653417C056AE996" modified="2013-05-29" version="1">MSNQQYKVKAIYLSQEKQIKTFEYDLLKPNDEFSKNDFLIELEKNIIKIQEDCNKILTEKINEKYPKTIPENDEDRRNQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPV3</accession>
    <name>M7NPV3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trafficking protein particle complex subunit 2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02484</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. Sedlin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874493.1">
        <property type="nucleotide sequence ID" value="XM_007876302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPV3"/>
    <dbReference type="STRING" id="1069680.M7NPV3"/>
    <dbReference type="GeneID" id="19896177"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02484"/>
    <dbReference type="eggNOG" id="KOG3444">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083394_0_0_1"/>
    <dbReference type="OMA" id="FHYIVHC"/>
    <dbReference type="OrthoDB" id="18320at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14854">
        <property type="entry name" value="TRAPPC2L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044760">
        <property type="entry name" value="TRAPPC2L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR09141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="177" mass="20048" checksum="E9C7C2865CEA41A8" modified="2013-05-29" version="1">MNPRIASVAVIGKQNNPLYLRVFSEKKTDLTYHFMIHSACDELEAALSRVSVEENTKKLQQNPLETNSNAKLNERSQTSVNPKTESLDAYLGLLHIQETAAGYGFVTNTQIKFIVVLDMSEMIITDADMKLLFKAIHSAYIVQVCNPFYSLDDKTPIQSRRFDKMIQQIVESWTSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ02</accession>
    <name>M7NQ02_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00916</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872828.1">
        <property type="nucleotide sequence ID" value="XM_007874637.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ02"/>
    <dbReference type="STRING" id="1069680.M7NQ02"/>
    <dbReference type="GeneID" id="19894614"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00916"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_536501_0_0_1"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000032">
        <property type="entry name" value="Krueppel-like factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="425"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR10768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="508" mass="58212" checksum="3717890BC0973446" modified="2013-05-29" version="1">MNLSSLEFKLMHHSDPLGSTFYSSKGSQMHMNQYLSPSLNTLSGSGRFYMNSTSIPVMQRDALTLFQPRSVYSATLNEENSMFHLFNTIHSFMGNEKQDLDEQDKDKIRNERAITVKMLQQNAIFEDKHLAVESICDIYQPSFDISDYILSGYETIIKSPRVFRSAVSPGSTTVSEFAPITPPSATNDLNYFDYMLPHTQPAALNQQWLVDMKQNSSNETHVDPSRLCVSPISQANFSVNESIVEKNLKHSENKDNKTGYDKQEELDEKVLVDASKNENDKKTEKIDLEHVEKPATILKTKKASKTKKSASKRRNESRYIEDVEYGLKPKRGRVPKEQRQKLLEMSTSAISNANSLVGLGISLHDSRYNQGMSTFFQDKVESDSKERDNANFPPHGVFLTKTKVSCRKYSQTHLQKRGSSIEKSFICEIIGCEKRFRRSEHLKRHVRSLHTGEKPFLCIVCHKRFSRSDNLNQHLRVHKISNGDNQNTLVNKRRTRMVTKKLRYHGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ55</accession>
    <name>M7NQ55_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinetochore protein Spc24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_00979</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
            <location evidence="10">Centromere</location>
            <location evidence="10">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SPC24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872893.1">
        <property type="nucleotide sequence ID" value="XM_007874702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ55"/>
    <dbReference type="STRING" id="1069680.M7NQ55"/>
    <dbReference type="GeneID" id="19894677"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00979"/>
    <dbReference type="eggNOG" id="ENOG502S52R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091441_1_0_1"/>
    <dbReference type="OMA" id="AQCTSHF"/>
    <dbReference type="OrthoDB" id="3344830at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11565">
        <property type="entry name" value="RWD_Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013252">
        <property type="entry name" value="Ndc80_Spc24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038066">
        <property type="entry name" value="Spc24_Fungi_globular_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08286">
        <property type="entry name" value="Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143026">
        <property type="entry name" value="Kinetochore globular domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 10" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR10833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="191" mass="22312" checksum="5E94DECAA8B92CF7" modified="2013-05-29" version="1">MPQELIQSTLSGFQIDLDLQSISRICERLDTISKNREIKQQNIKTISKNLERQLEISKSSIQAYENSPSRAEHASIILAMDRDKFSLAKNINELESSIHTLDTTYLRLKEELEELESEDIMKDNYEMTDDSTLLRLKIYRTLGIDLHEDEAGNYVKAIIRNKNNNDMHVVNIEPRYSSFFYSNYLWDLIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQE0</accession>
    <name>M7NQE0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">40S ribosomal protein S18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02261</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874250.1">
        <property type="nucleotide sequence ID" value="XM_007876059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQE0"/>
    <dbReference type="STRING" id="1069680.M7NQE0"/>
    <dbReference type="GeneID" id="19895954"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02261"/>
    <dbReference type="eggNOG" id="KOG3311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103849_0_1_1"/>
    <dbReference type="OMA" id="SYKGVRH"/>
    <dbReference type="OrthoDB" id="1702480at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.910.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_uS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="153" mass="17550" checksum="4F4740CB3FE07BFC" modified="2013-05-29" version="1">MSLVVQQQGTFQHILRLLNTNVDGRVKIMFALTQIKGVGRRYANLVCKKADIDLSKRAGELTVEELERIVTIIQNPLAYKIPPWFLNSQRAITDGKNSQVLANQLDNKLREDLERLKKIKVHRGLRHFWGLRVRGQHTKTTGRRGKTVGVSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQE7</accession>
    <name>M7NQE7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873000.1">
        <property type="nucleotide sequence ID" value="XM_007874809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQE7"/>
    <dbReference type="STRING" id="1069680.M7NQE7"/>
    <dbReference type="GeneID" id="19894785"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01088"/>
    <dbReference type="eggNOG" id="ENOG502SBJ2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_611276_0_0_1"/>
    <dbReference type="OMA" id="HENQAFR"/>
    <dbReference type="OrthoDB" id="3365399at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01763">
        <property type="entry name" value="Ubl_SUMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="375"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="448" mass="52561" checksum="C7359E476E0C36D1" modified="2013-05-29" version="1">MPNSKNEEKNIKTNKFQRKKDNKEIEKQYDEEIMFFSRKKTSFKSPETFTDVKYKYYSKKYDFSFDPTQISSSETFSSDENTLSSPKSISSESIEKLPIVISQENKESLEKNRSINISKKTHKNTHKKITNKSHSESSLSPSPSDRKRSISLTPPPRLSKQIIQEGHRMYMNLTQETKINKKAAKETNKSEEKENNNFYIYDNSNIETYDQYSTNETKNTDITELEAKEFPENNKKIEIFEITVIGKRNIKTDDIFFPESWEEPILFKIHENQAFRVMKNSFCSYKKLNKSYYDQVVLVFREKRIFESATPKGINMLKYGSKITINAMSKKEYKHLISEIEKRKRLKDEDIHDFSNSTEKTLESMTYIIIDDPPIELILRDKDNESIKLSIDTNATISKLIETFKTSKNINTNTNITLIFEGEYLEPNLSISYYDFENGDLIDVQINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQH9</accession>
    <name>M7NQH9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_00581</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR10978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872476.1">
        <property type="nucleotide sequence ID" value="XM_007874285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQH9"/>
    <dbReference type="STRING" id="1069680.M7NQH9"/>
    <dbReference type="GeneID" id="19894279"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00581"/>
    <dbReference type="eggNOG" id="KOG2662">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025144_1_2_1"/>
    <dbReference type="OMA" id="TRNNCII"/>
    <dbReference type="OrthoDB" id="10251508at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045016">
        <property type="term" value="P:mitochondrial magnesium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000005">
        <property type="entry name" value="Inner membrane magnesium transporter MRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.330:FF:000002">
        <property type="entry name" value="Inner membrane magnesium transporter mrs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR10978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="408" mass="46623" checksum="31606EA65CFD3E4E" modified="2013-05-29" version="1">MKKPFFISYKPYHCTFFLNLHYAFQQSIRSYTSASEFKPSTFFRTTSPILLENQELNNTRHVLEKALKSHKKNELLIKCTEFDATGCVKVVSGEFKKTDLCLKHGLLPRDLRKIDTGIQSLIPSILVRKNSILINLLHIRALLKADAVLLFNAYGSTDTHTQSVFMYDLEGKLRQGNKAAGGLPYEFRALEAILISVSTALDEEMKFLNSLVKDVLLRLEEDVHHQHIRNLLTYSKKVTAFEQKVTLIRNALNEILDQDEDLAAMYLTEKHQGKIRPLDQHDEIELLLESYLKQTDEIVQSVNNLVSNIKNTEEIVNIILDTNRNTLMQMELKISILTLATSSGAIITGLLGMNLKNFMEHWPYAFAIISSLALAIATIVGTLGLKKIKKIQRLSLWGKEQKFIKYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQR6</accession>
    <name>M7NQR6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">E3 ubiquitin-protein ligase listerin</fullName>
            <ecNumber evidence="5 16">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">RING-type E3 ubiquitin transferase listerin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PNEG_00665</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Mediates ubiquitination of proteins derived from mRNAs lacking stop codons (non-stop proteins) and other translation arrest products induced by poly-lysine sequences and tandem rare codons. Ubiquitination leads to CDC48 recruitment for extraction and degradation of the incomplete translation product. May indirectly play a role in chromatin function and transcription.</text>
    </comment>
    <comment type="function">
        <text evidence="16">E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the ribosome quality control complex (RQC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the LTN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 16"/>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872565.1">
        <property type="nucleotide sequence ID" value="XM_007874374.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NQR6"/>
    <dbReference type="GeneID" id="19894363"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00665"/>
    <dbReference type="eggNOG" id="KOG0803">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002223_0_0_1"/>
    <dbReference type="OMA" id="IYGSHWE"/>
    <dbReference type="OrthoDB" id="6108at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16491">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000038">
        <property type="entry name" value="E3 ubiquitin-protein ligase listerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039795">
        <property type="entry name" value="LTN1/Rkr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054477">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054476">
        <property type="entry name" value="Ltn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054478">
        <property type="entry name" value="LTN1_UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039804">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE LISTERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389">
        <property type="entry name" value="ZINC FINGER PROTEIN 294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22958">
        <property type="entry name" value="Ltn1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22999">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23009">
        <property type="entry name" value="UBC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 15 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="1591"/>
            <end position="1638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMR11068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1645" mass="193017" checksum="E588BC7D3408079C" modified="2013-05-29" version="1">MKQSVKNYKNEKERLNELLKSPTSVSIQNKNNVSKFKFGTYGNMRECNLSSFIIEPLDFDGVPPNLVVIFKNICKRDTTTKLKGLDDISSWINENGGELNENNILKVWSYLYPRLSIDIDRQVRLSCNHVHRKIYIQSGKKIVKFIKEIIGSWIMSTFDSDHGVKKVAIESFNTAFQTREKRLIVKKTYHKYILSFNKNIILKQSPSTLSDLRYISQEDSKAKYYRIIASILASFADIILNLELDELKKEEASYDEIMASEKFWKFLYETDFIGRKYFYEVIKNLSEKWPELLISQKNMIKKSVAKLMKNTEKSFISIILPTMEIFFSVCPELWEYDFFGDSEIFSYFKRLMLNNDSNSKQFWNCFYNLITKIPLNPHKSHFDVYLNDFIRMIWEGASKKTKYDNEAGFETFFKIMCYYMKHFENTRTISSIFEKKIMDIIINYFTDIKSLNTKTSDDFRHALVKGFLRNEYILNDIFNKFWYESKQCILEKLSKTSNIICEENYDEPFTVCLRWINTVDEFIKETDDNTVLADKSHVYLTICEVIYFIICHIRRSDDLPQKTIELLNCVVSKFSDIIFKNQRILSELESFIMEKIPKFITSLTESIGSILLIYIVKNKNTESVGLVWTSLFLHLSKIESRSERNVFTHKIAKMIIDSKINIEDLRNCLPCVNLIDDVLLDCVHFNIDNNFENWECLNDFLTVKEIVFSKESIVESLIFLVEKVFCPNDSEFYYIFNDDRILVLLHNVLGDNFDLCSCFLQNFRAIEFHIKIWNFTYINKGDISERISIFNDLFEKIYCLNNKIGSNLRFNIANIIQKQILLLDSLDFSLMRSLCSLNVKVLSFATESEKMDLLAIFLFSTHEWDTAFSFLISEYPNKNLELFSSLKTCCLIFSNFVKTKGNIETDNISKLLKMSVFSKTIINSLILDLCSLKIHWLILYGIMICEELIRDNFELEHANCLWKSITKEQEQELFTLIERSDDFVFDILTSDKIELFGIDNFVQRNDIKFLEKIKMKSIGCSPETYYSACVLSRTFQFLTKRIEYSQEEVETWLNDISIENDQNVFIFAAVINGFQQKLFFSKRLEGIRNRIGSDISGDFVVDRDLKKIVLFNVFIPFDGSLWKHFPQQRIIFLFQNLLKLIDKKNIIKVQNIDFCAEITKIFIKLIPFVKTIDGLYWYNICDYLCQCLKICIETSLDFLNFEFYSMKLFMTLSNCYSFNDSFNDAWNIHSKTLYSHLFQLFIHKKETHAKNQPLDICIQLLSRILLQIPIAIVEKPLVNSLYLHLLSQWKYTQITTFDWLTKWILKDQENLIVETEFSKEIDIDLPSKLLFMISDLPCYDSLDNIDHENNLSSKLRGYFLSWILIFTYFKNTSYILKSHYIESLKNSNCIPLTIEFIFKTLELLSDKPINAIEISWDILEWKSADNIKTEILSLMVYVYLLILRYIPSLARDWWIGCKNRQLTQSVETFTEKNISSILIEDEIASVLLESIQLKINDDNIHVKTSKTTREVTTSYTIDDQYLEMVIRLPACYPLNQVIVEGIQKIGVKDAQWRAWLLASRILITTQNGSIADAVSLFKRNVSLHFEGVVACHICFSIISVQDRSLPSKKCAICKNKFHSGCLYKWFKTSNASKCPLCRTTFSFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQV5</accession>
    <name>M7NQV5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">K37</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">K5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">KD4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00701</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 33 different proteins. The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and at least 46 different proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872600.1">
        <property type="nucleotide sequence ID" value="XM_007874409.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQV5"/>
    <dbReference type="STRING" id="1069680.M7NQV5"/>
    <dbReference type="GeneID" id="19894399"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00701"/>
    <dbReference type="eggNOG" id="KOG2309">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036235_0_3_1"/>
    <dbReference type="OMA" id="HPYKFKM"/>
    <dbReference type="OrthoDB" id="10267824at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000020">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000006">
        <property type="entry name" value="60S ribosomal protein L8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023672">
        <property type="entry name" value="Ribosomal_uL2_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007180">
        <property type="entry name" value="PRK09612.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 10" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="9">
        <location>
            <begin position="2"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="8">
        <location>
            <begin position="95"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00062148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00079874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00080160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00080743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="254" mass="27829" checksum="D35B1FA4AAFA64C6" modified="2013-05-29" version="1">MGRVIRAQRKCGGIFKAHQRLRKGAALHRVLDYTEKHGYYRGIVKEIIHDPGRGAPLAKVVFRDPYRYKKRIETFIANEGMYTGQFIYVGKKASLSVGNVLPLGNMPEGTIASNVEEKTGDRGSLGRSSGNYVIVIGHDPDNGKTRIKLPSGAKKVVDSTCRGMIGIVAGGGRIDKPILKAGRAYHKYRVKRNCWPRTRGVAMNPVDHPFGGGNHQHIGHASTVSRYAPAGQKVGLIAARRTGLLRGNIRIKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQY2</accession>
    <name>M7NQY2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL6 alpha-beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02107</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874089.1">
        <property type="nucleotide sequence ID" value="XM_007875898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQY2"/>
    <dbReference type="STRING" id="1069680.M7NQY2"/>
    <dbReference type="GeneID" id="19895801"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02107"/>
    <dbReference type="eggNOG" id="KOG3255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065464_0_0_1"/>
    <dbReference type="OMA" id="YAHFPMK"/>
    <dbReference type="OrthoDB" id="10252633at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000003">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000004">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002359">
        <property type="entry name" value="Ribosomal_uL6_CS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF16">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00700">
        <property type="entry name" value="RIBOSOMAL_L6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="97"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="188" mass="21697" checksum="2C26330484AE45FB" modified="2013-05-29" version="1">MKEICKQQELVIPDNVKVDIKARVVRVTGPRGFLKQNFQHINIDIRKIQANRIRLIIWHGGKKHVACLRTIRSLINNMIIGVTQGYRYKMRFVYAHFPINVSIGEEGKLIEIRNFLGEKVVRRVNMLEGVKVELSKSQKDEIILEGICLENVSQSAASIQQICNVRNKDIRKFLDGIYVSARETIEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRB5</accession>
    <name>M7NRB5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone deacetylase complex subunit SAP30 Sin3 binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01965</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873943.1">
        <property type="nucleotide sequence ID" value="XM_007875752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRB5"/>
    <dbReference type="STRING" id="1069680.M7NRB5"/>
    <dbReference type="GeneID" id="19895659"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01965"/>
    <dbReference type="HOGENOM" id="CLU_2085793_0_0_1"/>
    <dbReference type="OrthoDB" id="510958at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024145">
        <property type="entry name" value="His_deAcase_SAP30/SAP30L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038291">
        <property type="entry name" value="SAP30_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025718">
        <property type="entry name" value="SAP30_Sin3-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13286:SF22">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13286">
        <property type="entry name" value="SAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13867">
        <property type="entry name" value="SAP30_Sin3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase complex subunit SAP30 Sin3 binding" evidence="8">
        <location>
            <begin position="49"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="117" mass="13672" checksum="91630D45B6E981EE" modified="2013-05-29" version="1">MPPRPKQNESEVSQELLDRSGSRQKRSSADRLENCIVRESIPIFNANTLPIATLRKYQNVFKLRTQVNSSSNDALVNAVQRHFNALPVKEYDMIVQFLYTVKNKDKTFRRYFHNEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRZ8</accession>
    <name>M7NRZ8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00539</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872429.1">
        <property type="nucleotide sequence ID" value="XM_007874238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRZ8"/>
    <dbReference type="STRING" id="1069680.M7NRZ8"/>
    <dbReference type="GeneID" id="19894237"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00539"/>
    <dbReference type="eggNOG" id="KOG2839">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_5_3_1"/>
    <dbReference type="OMA" id="ESDESCQ"/>
    <dbReference type="OrthoDB" id="2011998at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034431">
        <property type="term" value="F:bis(5'-adenosyl)-hexaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034432">
        <property type="term" value="F:bis(5'-adenosyl)-pentaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008796">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052745">
        <property type="term" value="F:inositol phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052846">
        <property type="term" value="F:inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052847">
        <property type="term" value="F:inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052843">
        <property type="term" value="F:inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052845">
        <property type="term" value="F:inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990174">
        <property type="term" value="F:phosphodiesterase decapping endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901911">
        <property type="term" value="P:adenosine 5'-(hexahydrogen pentaphosphate) catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901909">
        <property type="term" value="P:diadenosine hexaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901907">
        <property type="term" value="P:diadenosine pentaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071543">
        <property type="term" value="P:diphosphoinositol polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071545">
        <property type="term" value="P:inositol phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04666">
        <property type="entry name" value="NUDIX_DIPP2_like_Nudt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047198">
        <property type="entry name" value="DDP-like_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629:SF0">
        <property type="entry name" value="DIPHOSPHOINOSITOL-POLYPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="37"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR11528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="200" mass="23236" checksum="DA4213263F865F19" modified="2013-05-29" version="1">MADFQGERTNVTPIVTPVERSMISRTDRTKERYDETGARLVAGIVPLSSAKTHPGYPERKYILCISSTNNKQSWVLPKGGWEIDELIEEAALREAWEEAGIVGKITCSLGMMHDPRPAKTFQRAVKYVMQENHPYMFHDSCIPPRAVFQYFELDVERLEDEYPEMNKRIRKWMTYSEAKEALAWRLEMVEALERSSILKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSA3</accession>
    <name>M7NSA3_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873366.1">
        <property type="nucleotide sequence ID" value="XM_007875175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSA3"/>
    <dbReference type="STRING" id="1069680.M7NSA3"/>
    <dbReference type="GeneID" id="19895123"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01426"/>
    <dbReference type="eggNOG" id="KOG2948">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051576_0_0_1"/>
    <dbReference type="OMA" id="FHCDEVV"/>
    <dbReference type="OrthoDB" id="10265310at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901857">
        <property type="term" value="P:positive regulation of cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003226">
        <property type="entry name" value="MYG1_exonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215">
        <property type="entry name" value="METAL DEPENDENT HYDROLASE - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215:SF1">
        <property type="entry name" value="MYG1 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03690">
        <property type="entry name" value="MYG1_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="322" mass="37267" checksum="642C1BEEF37D9EDA" modified="2013-05-29" version="1">MANKKIGTHNGTFHADECLAVYMLRLLPEFKNSEIIRSRDPEVLETCDIIVDVQGKYDGIKYFDHHQKYFNETFSENFKTKLSSCGLIFKHFGKRIISERLTLDINHPHVDILYVKLYESFLEALDANDNGISPYPQNIRPLFKTQLELSSLVANFNPRWNQPSDDTVLFNLFLKASDFIGSIFLDQLDYYGRAWIVARELILEAFKKRFKYDSEGRIVVFDEFLPWKSHLAQIEHEFNANGQILYALYTDGKDWRVHAVPVTPDSFTSRKNLPEKWRGLRDKILSLECNIEDCIFVHASGFIGGNKTKEGALQMAKKALIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSM0</accession>
    <name>M7NSM0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_01400</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873335.1">
        <property type="nucleotide sequence ID" value="XM_007875144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSM0"/>
    <dbReference type="STRING" id="1069680.M7NSM0"/>
    <dbReference type="GeneID" id="19895097"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01400"/>
    <dbReference type="eggNOG" id="KOG0207">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_0_1_1"/>
    <dbReference type="OMA" id="WECFFDE"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012510">
        <property type="term" value="C:trans-Golgi network transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060003">
        <property type="term" value="P:copper ion export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000005">
        <property type="entry name" value="Copper-exporting P-type ATPase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="852"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="881"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="11">
        <location>
            <begin position="119"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR10121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="949" mass="105714" checksum="8F99DAC39AF8F976" modified="2013-05-29" version="1">MNLQSRVKKSYKHVSPIALENMLENQKIDDFRKTVLSIEKISNFSCISTMKENLKKNSGILNINIFSAKKIIIEHKISIISINDLIYELKNVGIETSLINSETILYKIDFDNHDAINDTTIRLKISGMTCYNCVNSIKTVLESINGVNNVCINLATKEAKINYCPKISSIQSLINAIKKKGYDADILDFYSTEEKLENLNKTKDIELWKKTFIKCLIFAIPLLFFQKVAPHFKDYNKIETKVLFFPGLFFGDVLSLILTIPIQFNIGIYFYKSAFNSLYSGDITMDTLICIGTSTAFIFSIFSIILSISTYPHKRPSVFFDTSAILITFITLGRYIENKVKSHTSETLSKLISLNPSSTTIYINKTNPLDRKEITIPTKLLNVNDTVIIYPGDRIPADGVIISGESYIDESMITGESTPVYKQKGSIVYSGTVNCAKRIEFEVTKTDKDTRLSQIISLVQDAQTSQASIQKFADKVSSFFVPLVLFLGVMTFIVWMILSHTISHLPQIFNSEEQGGKMIMSAKLAISVIIIACPCAVGLSTPTAIMVGTGIGAKNGILFKSGIVLETVSEITKVVFDKTGTLTVGYMSVNEVKISNAWKDLEILWWKLVYISEERSEHPIGKAIQSKAKKELNLAGEELINYSATSEAIAGYGVKCSILLPNCTEESTELAIGSEVYIRKILGDQCEEFLNETQNNLNKEYTHVYIAINNKFAGWISLTDILRANAAQTINALKHMKIDVLMATGDSTDIALKVGRSLNIPDDKIYSSITPEEKYNLIIYLQSQNETVAMVGDGINDSAALTVANIGIALSAGSDIAIQAADVILTHPDPILDVPAAIHLSRAIFNRIRLNMLWACIYNIISIPFAMGFFLPFGIYLHPVISSAAMACSSISVVLSSLLLKFWHRPSWITNVDISENDVRGSKSFISKLKNCNIFYKFKKYRLINNLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7NT63</accession>
    <name>M7NT63_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01186</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873101.1">
        <property type="nucleotide sequence ID" value="XM_007874910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NT63"/>
    <dbReference type="STRING" id="1069680.M7NT63"/>
    <dbReference type="GeneID" id="19894883"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01186"/>
    <dbReference type="eggNOG" id="KOG3406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110343_1_0_1"/>
    <dbReference type="OMA" id="DLGQWVG"/>
    <dbReference type="OrthoDB" id="10249311at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990145">
        <property type="term" value="P:maintenance of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000530">
        <property type="entry name" value="Ribosomal_eS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047860">
        <property type="entry name" value="Ribosomal_eS12_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11843">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00972">
        <property type="entry name" value="RIBSOMALS12E"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01189">
        <property type="entry name" value="RIBOSOMAL_S12E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="5">
        <location>
            <begin position="22"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="136" mass="15024" checksum="F928D9D728D5E525" modified="2013-05-29" version="1">MPEGDEVSEIGAGRSSMSVEEALQEVLKKALVHDGLARGLRECVKALDRRQAHLCVLSESCDEEAYTKLVEALCAEHNINLVKVSDSKKLGEWAGLCTLDREGNARKIVRSSCVVVKEYGEESEALNVLLDYFKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTE4</accession>
    <name>M7NTE4_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01258</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRDE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873181.1">
        <property type="nucleotide sequence ID" value="XM_007874990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTE4"/>
    <dbReference type="STRING" id="1069680.M7NTE4"/>
    <dbReference type="GeneID" id="19894955"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01258"/>
    <dbReference type="eggNOG" id="KOG1972">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007550_0_0_1"/>
    <dbReference type="OMA" id="QEYARPN"/>
    <dbReference type="OrthoDB" id="297219at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902369">
        <property type="term" value="P:negative regulation of RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013633">
        <property type="entry name" value="NRDE-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471:SF0">
        <property type="entry name" value="NUCLEAR EXOSOME REGULATOR NRDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471">
        <property type="entry name" value="TETRATRICOPEPTIDE-LIKE HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08424">
        <property type="entry name" value="NRDE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="773" mass="92103" checksum="20FFBDAE5C0CAE8E" modified="2013-05-29" version="1">MNQIPKFNSFKTHLLQKQKDLHKKEETQELLDDLKKKKSYIEDEEYEKKNINKISYDRKKIEEKNKLFIIDLSGDINNIKYGKNDQYSIPYYRRSGHGRVLGCKENIRLRVYPENPNEIILFPLSSYNNYKKVFNSELNQNLQYLKEAKESNHFNEVNYQENYIPFEVENSDTPSITNDSKNHSNNISPESDKIENDVNILHIWKKGDPQLELKELSKKIEESPLDYKSWLKLVDIQDKILWTNNNKKSKVEQLAVNEVKLKILEKALSHCPDNDDLLLKYMSIIILIWEPQKINLEWNKILKKSLSLPLWKKYMDFYQTNSISFAYNECLENFQNNLQILKEASKNEKCQRKIENIEEIIQYILIRIWFYMKEAGYTENSIASIQALIEFNFFMPNNFLSNINDVNCLQDFEQFWDSEVPRFGEDGAKGWKNYHNKYQHIVLFENDSSDISLSNNENISQNIEDEYTKWYKQETAKNSYINPKRSTNTNTENDPYSVILFSDIEQLLYFFTTDRIRLGLIYFSLHFFGFSLHRIDKTSNESPLLDSFIQDFLPIDSFNWFWSNEYLSLKPSQQFNKNAIDSDYLLKHLKSPVHIKLKNWPITIDTLFSIDNTWYQNIDCQGFDKDFIKRYFEQLESVIDDDLFSMLHLLFRNYYSSSDVRKLAKFILKKKPLNMKLWCAYAQLEYINGNILEARKIFVNTLKNIKPDHTEKFYDYLVAYKLWAEIEMKNNEINNSIKILVSMVESELNIETLIFNDEKICSDSILLKAQKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTH8</accession>
    <name>M7NTH8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_01292</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873216.1">
        <property type="nucleotide sequence ID" value="XM_007875025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTH8"/>
    <dbReference type="STRING" id="1069680.M7NTH8"/>
    <dbReference type="GeneID" id="19894989"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01292"/>
    <dbReference type="eggNOG" id="KOG1195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006406_6_2_1"/>
    <dbReference type="OMA" id="YEFKWER"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07956">
        <property type="entry name" value="Anticodon_Ia_Arg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000058">
        <property type="entry name" value="Mitochondrial arginyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR anticodon binding" evidence="11">
        <location>
            <begin position="488"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR10587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="605" mass="69697" checksum="6FC7A820EFC21B63" modified="2013-05-29" version="1">MRRINTFDDLLESFKEFGISENILYCENSNPIRNPYDIFRLYIAHSLSKITGISNKEIYPILEHGSKLENGDLMLPVARLRLAENPVSLAKEWSEKFPQRIVYSKHQGAFIQFFFCPEFLTHLVIPYIHRDGDKYGYNESGKGKKVVIDFGSPNIAKPFHAGHLRSTIIGAFVSNIHEFCSWKVVRLNYLGDWGKQFGLLAIGFQLYGNEEALESDPIQHLYDVYVKVNSFASKKDNPEADDLNNKAREYFKRMEEGDETALSIWRRFRDLSIEKYKITYNRLNICYDEYGGESKVSPESIKMVINSLKERGLLTIDDGAMFIDLSKYSKNLGKAMLQKRDGASLYLTRDIGEAINRYEKYEFDKMIYVVSSQQDLHLAQLFKILELLDLPWAKSCIHINYGLVLGMSTRKGTAVFLDNILETAKENMHDVMKKNEKKYSQIEDPEYVSDVVGISAILIQDMSSKRINNYSFEWPRILTFEGDTGPYLQYAHSRLESVIRRQNISLEDIQKAKLDFLTEPAAIDLIRLLARYPDVINTTIKTLEPCTIITYLFKLTHTVSGCYDLLWVMNQSQDVAMARLSLFLACKRVLGNGMRLLGLTPLERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTJ1</accession>
    <name>M7NTJ1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873046.1">
        <property type="nucleotide sequence ID" value="XM_007874855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTJ1"/>
    <dbReference type="STRING" id="1069680.M7NTJ1"/>
    <dbReference type="GeneID" id="19894828"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01131"/>
    <dbReference type="eggNOG" id="ENOG502S0YW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_776400_0_0_1"/>
    <dbReference type="OMA" id="QWQHNAT"/>
    <dbReference type="OrthoDB" id="2430277at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051412">
        <property type="entry name" value="Formin_Homology_Diaphanous_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691:SF6">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="2">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="357" mass="38577" checksum="EB54C1A1CAC726CA" modified="2013-05-29" version="1">MSSQLAKPISHNSFSNKNEKSLIDNQNMDALLIQIQKGKVLKKTITNDRSAPIIKKVVSYEISNRVASTMSNSSKSSSNHSEPPSFVQKLPELFQDGAPKLKHREGGVNTGAIHIENAANSKNMQSSSKRESNAVQTSLLRNNSTSSRSVSDSQKTTYKKTSSTVLTRPICLPPPIPRTISMSVSKKTDVQGSSIIPPLAPPPPPPPPPPPPPPPTRNVSLSTPSTAPPPPPIPSSIAVNKTSTRPPPPPPPPPPPPHLSSSMAANTSKETYIYRSSSVLSSQGSLSRQNKSYVSLNFNKLYTGPGIKPSNINIMIDDSRWRFKDEDEFPAPRTFSGEQKIFRSGRQGGSTVPLNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTK3</accession>
    <name>M7NTK3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Maintenance of mitochondrial morphology protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MMM1</name>
        <name evidence="10" type="ORF">PNEG_01147</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <text evidence="8">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MMM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873061.1">
        <property type="nucleotide sequence ID" value="XM_007874870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTK3"/>
    <dbReference type="STRING" id="1069680.M7NTK3"/>
    <dbReference type="GeneID" id="19894844"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01147"/>
    <dbReference type="eggNOG" id="ENOG502QUUW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1220129_0_0_1"/>
    <dbReference type="OMA" id="MHHPPES"/>
    <dbReference type="OrthoDB" id="5599157at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21671">
        <property type="entry name" value="SMP_Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03103">
        <property type="entry name" value="Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027537">
        <property type="entry name" value="Mmm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019411">
        <property type="entry name" value="MMM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF0">
        <property type="entry name" value="SMP-LTD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10296">
        <property type="entry name" value="MMM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="topological domain" description="Lumenal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="9"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="9">
        <location>
            <begin position="25"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR10431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="227" mass="26023" checksum="C98C065C995C602F" modified="2013-05-29" version="1">MLRTSFSPRISHIVSKLYENIETRTSESLDWFNVLIAQAIVLFRNDYDFKEALLVYMSDILNGTNKPSFLGHVKVIDMNLGEEFPICSNCRIVSCSSNPERLNAVMDVNLVDQITLGIKTQFLLNYPKYEFAVLPIELSLSIMRFSGTLSISLIPCEKQLNASNIAAFIFSFSPDFQLDIDVHSLVGSRSKLQDIPKISQFLEFRIRNWFMENCVEPHFQRINIPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTQ6</accession>
    <name>M7NTQ6_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873120.1">
        <property type="nucleotide sequence ID" value="XM_007874929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTQ6"/>
    <dbReference type="STRING" id="1069680.M7NTQ6"/>
    <dbReference type="GeneID" id="19894900"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01203"/>
    <dbReference type="eggNOG" id="KOG4635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_733876_0_0_1"/>
    <dbReference type="OrthoDB" id="62at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534:SF3">
        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="377" mass="44474" checksum="23043BCDECA624F0" modified="2013-05-29" version="1">MRAPFYMSTTFEHNRSIQEHPRSSIFQRHRRMRNRNERPNQWFQVNRNDELWHGDTDENSISFDNSADHFPIRLSALRAIVVDSNGFSNNGINTFDHYYMRNALRSLDYDYISSAFERHSGRRRNYFSGGVISFDREGSSHYLEEVLNFLENTLVSPLTRDRLNFQNIPSTDDCTKIEYTSWLKSGSIFQGVQNFPGQPSIFLSESSHIRDERKIKVIIQDINFSKMSVSGQIEMFNASDVDFNNSSIIIWWNGEIVDFVGYYNLLAVKRGIAWKTDVAYWRKLEPFKGMDDYEFFNLLFAKDKITDICSKYIFMRWKESEFIGPFMFESDFATSGSYFCCLRRNDGFIEGYYFDPSLSCQYISLYPKMNDGVFKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUC9</accession>
    <name>M7NUC9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RAVE subunit 2/Rogdi</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872771.1">
        <property type="nucleotide sequence ID" value="XM_007874580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUC9"/>
    <dbReference type="STRING" id="1069680.M7NUC9"/>
    <dbReference type="GeneID" id="19894559"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00861"/>
    <dbReference type="eggNOG" id="ENOG502S2HP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_977026_0_0_1"/>
    <dbReference type="OMA" id="IMINICI"/>
    <dbReference type="OrthoDB" id="66510at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028241">
        <property type="entry name" value="RAVE2/Rogdi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618">
        <property type="entry name" value="LEUCINE ZIPPER CONTAINING TRANSCRIPTION FACTOR LZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618:SF1">
        <property type="entry name" value="PROTEIN ROGDI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10259">
        <property type="entry name" value="Rogdi_lz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="32901" checksum="AEA3479AE2DA1AB1" modified="2013-05-29" version="1">MSGNAQVASNNYEKIWKDKHLLLTKIELEWFISTIVPEIFKKINRHLNLCMEALSDEKSLTLVLSSIQSETIKGFLTRRGTSLIKGKFQIIFKNNIKLNQFYIKNTILLEQLSHLNDIICQSQIVLQTETTDADSIQKIINQLHLHIQSAQQILYPNEPINDLIYSLKNNDLDPPLPSNIMINICIDYTSIATHIYLLAEQNFTQRFSFLSRLFSFNGWKTTNPRSITINQQLMQIIDEIHLKSRDPALSIIIDHLTAIEYEVNHLKLNIDVLQKNINTSESTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUG3</accession>
    <name>M7NUG3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome c oxidase subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cytochrome c oxidase polypeptide VIa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_00890</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome c oxidase subunit 6A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872801.1">
        <property type="nucleotide sequence ID" value="XM_007874610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUG3"/>
    <dbReference type="STRING" id="1069680.M7NUG3"/>
    <dbReference type="GeneID" id="19894588"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00890"/>
    <dbReference type="eggNOG" id="KOG3469">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122515_0_2_1"/>
    <dbReference type="OMA" id="KLPWMVD"/>
    <dbReference type="OrthoDB" id="5947505at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.95.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6A, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.95.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001349">
        <property type="entry name" value="Cyt_c_oxidase_su6a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018507">
        <property type="entry name" value="Cyt_c_oxidase_su6a_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036418">
        <property type="entry name" value="Cyt_c_oxidase_su6a_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02046">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81411">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01329">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR10741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="129" mass="15485" checksum="D59EC29631ED5E74" modified="2013-05-29" version="1">MLWRYFLRKNTLIKDLRSIRHCNYTTEARTGHDFVLEQEIIKKHAGKTADLWKKITIFVCIPALLITSLNAYQLYTKHHSKLSHELEEKENDSTPEYPYQNIRTKRFFWGDGDKTLFWNDRVNKHKISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NV88</accession>
    <name>M7NV88_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TBP-associated factor 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_00644</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872543.1">
        <property type="nucleotide sequence ID" value="XM_007874352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NV88"/>
    <dbReference type="STRING" id="1069680.M7NV88"/>
    <dbReference type="GeneID" id="19894342"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00644"/>
    <dbReference type="eggNOG" id="KOG2341">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_759021_0_0_1"/>
    <dbReference type="OMA" id="KYSWMAT"/>
    <dbReference type="OrthoDB" id="21060at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08045">
        <property type="entry name" value="HFD_TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045144">
        <property type="entry name" value="TAF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007900">
        <property type="entry name" value="TAF4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15138">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15138:SF14">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05236">
        <property type="entry name" value="TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID component TAF4 C-terminal" evidence="10">
        <location>
            <begin position="67"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="190"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR11046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="348" mass="38428" checksum="D0603E5AE5D2C2B1" modified="2013-05-29" version="1">MDLKRSSNEDTPSSKKQKGSVNLSGQAVFSPPVSKSNSYLYSGSKGAVNAAVNTGKTSDNRQDAEQLQDALISAGVDIKEEEHNMSRSYDYVFGSNVIPLEEDRTKMTDFLNPIPLNDLIYRIAISNSLKTIDPDIGPLLALSLRDRMANLLSDMIVLSRHRTASLPVNRKIIDNVGKILEDINIKEKDKEEKRRAQVLSKKLEEENRMDKQTLLSGNPEDMDKKKKKKEILSNSSSKNLSEDAQKRNTDTTAAIMMGSGPNGPGGKKYSWMTSALPLSPGYITKTPRATSNHSQTNPETTIIQTVEEIGIITIRDALNVLEMDKEGAGEIFGRGARALSRGYIRLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWD9</accession>
    <name>M7NWD9_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ubiquitin-60S ribosomal protein L40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_00053</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871907.1">
        <property type="nucleotide sequence ID" value="XM_007873716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWD9"/>
    <dbReference type="STRING" id="1069680.M7NWD9"/>
    <dbReference type="GeneID" id="19893751"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00053"/>
    <dbReference type="eggNOG" id="KOG0003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010412_4_1_1"/>
    <dbReference type="OMA" id="EPEPTMQ"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000008">
        <property type="entry name" value="Ubiquitin-40S ribosomal protein S27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9 12" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="11">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR11612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="144" mass="16274" checksum="6075C994428DD063" modified="2013-05-29" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGAIQRCTMKQCSASAVRIVGDCNFCDGHFCGRHRQLENHACTGLQECRQQSHERNRTKLQKEQCVASKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWK5</accession>
    <name>M7NWK5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871967.1">
        <property type="nucleotide sequence ID" value="XM_007873776.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWK5"/>
    <dbReference type="STRING" id="1069680.M7NWK5"/>
    <dbReference type="GeneID" id="19893808"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00110"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018406_5_3_1"/>
    <dbReference type="OMA" id="CHCAKCA"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="54351" checksum="B195FDBB095DB792" modified="2013-05-29" version="1">MVKPLVAILDEKHISNGCSNCFICEEDKDDSEIYLMPCKACKILQYCCQKCMEEDWNMFHKYECSFFSSKWPKIIPGFMRICMRLIFYGRNHPSSLEWNTIKELESHLSEIMSSEKKEEILILSKGIQNFTNEPNEMLVLNLLCKIMINSFSLLTSSYDTIGTALDPTISRIDHSCYPNATLVFERNKIALRSLQKISMNQEITISYIDANNTQKNRQNELFSRYYFLCKCIRCKFPEKDESYLVLKNNMSIETFSHLEMLINKALSEKNINILRVLSILHRLKGWNSALYPLNELHKLALMYFLDENKIYNAFCHGLFIHLIGNRVFNKYMVDFNPVYVIQKFLLIKLIIFQASENCETQFKQINAKDMMIYAYKLLYDVIKLSYKSHGSSSRFSKRLQKTFEKTGEDISVYYWGKYWQSILKDDPENLEIKKECLRIEDNFLSEVKKYIEICIINYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWK6</accession>
    <name>M7NWK6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL30m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00546</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872437.1">
        <property type="nucleotide sequence ID" value="XM_007874246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWK6"/>
    <dbReference type="STRING" id="1069680.M7NWK6"/>
    <dbReference type="GeneID" id="19894244"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00546"/>
    <dbReference type="eggNOG" id="ENOG502S7S3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131047_0_2_1"/>
    <dbReference type="OMA" id="FHPAEPQ"/>
    <dbReference type="OrthoDB" id="509901at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000010">
        <property type="entry name" value="Large subunit ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_uL30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="8">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="82" mass="9421" checksum="0F5672DD3ABAE0AE" modified="2013-05-29" version="1">MGYFKITLQRSSIGLPKNIKRTLLSLGLRKRLSTVYHSISPVTAGKILKVKELVSVEEVDKRLTSIEMKRLRRPDKGYYVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>M7NX10</accession>
    <name>M7NX10_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="5">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00247</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="5"/>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872117.1">
        <property type="nucleotide sequence ID" value="XM_007873926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NX10"/>
    <dbReference type="STRING" id="1069680.M7NX10"/>
    <dbReference type="GeneID" id="19893945"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00247"/>
    <dbReference type="eggNOG" id="KOG1867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008279_11_2_1"/>
    <dbReference type="OMA" id="NVSCNCI"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF937">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="7">
        <location>
            <begin position="24"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="6">
        <location>
            <begin position="188"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR11822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="523" mass="60718" checksum="17485BF2E86418B2" modified="2013-05-29" version="1">MYLSTLILILLVKNNKKKISKYMSGCDHVWQLLSSPSKDFVCKTYFLAVNAIYFHKISKCERRSFSYKVFQKCSICHDFLKRTFLCLQCSHIGCWRRKHADIHSRIKNHVFAIDSYNGYLYCFACNDFVYDEFFEKIYLLAKRRLNLGLLNVKNSTYLLNKELKMTIENLDYLNEDDARVICCGDGLRGIQNMGATCFMNVIIQCLVHNPIFRNYFLSDSHIIKDCLQDNCSCCAMDTVIAEFFSKKDFSIPFGPCAFLEVMWKLSKELKGYAEQDAHEFFVCLMSLIHNHSGSKIDSTCDCVAHRTFSGILQSDVTCSACGNMTSTMDPIMDVSLELKIKRTPEIKSPSGEHLVRSLQECLQIFTSAESLANNEYKCSKCLSVSEKAIKQLKFKRIPLVICFQLKRFEHSSTPTKIDTHVSFSFQLDMFPYIVQDNYTNYNDDCVYDLLCVVCHQGQINTGHYTCFARSNDNWFQFDDTTINIANEKTVLASNAYDCVFLYLDLIEYRYLLFYIRRKLSYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7P2J5</accession>
    <name>M7P2J5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Rad4 beta-hairpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_03543</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875636.1">
        <property type="nucleotide sequence ID" value="XM_007877445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P2J5"/>
    <dbReference type="STRING" id="1069680.M7P2J5"/>
    <dbReference type="GeneID" id="19897230"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03543"/>
    <dbReference type="eggNOG" id="KOG2179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003639_3_1_1"/>
    <dbReference type="OMA" id="TWPGKTK"/>
    <dbReference type="OrthoDB" id="300780at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2460:FF:000001">
        <property type="entry name" value="DNA repair protein Rad4 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.290">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="7">
        <location>
            <begin position="468"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="8">
        <location>
            <begin position="530"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="9">
        <location>
            <begin position="600"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="729" mass="85097" checksum="F258C372B3C32F63" modified="2013-05-29" version="1">MSRLNNVKNIKRNRSDSLSDNEDNLKLSDKIDKKIVYDQTSKYFSKNTSFKTEEFLDDKFESNLLDSCFQDSGESSVDWEDVEIYQKISLKDGDLKDDSLENLDIVLNNQKKSKFKKKVSNINSLKRNIRVQIYLLHLTCLVFHGFFRNKWINDKETHDILRNKLKEESPLLFGKIENYRQILLNKRSDLLNFKKMLLMILKWFKQRFEIIALGIGKLDSYSTKCDFCLKNKACLFETIESIYEFRKIATFLKGSRDSGTQILTSLLRAFGFNARLIFSLQPIGLNFNLEDYEIHKEKCFESKKCSNDKFKNSKKARVGISENELDNTFIKSEENLVDKTELVLDSCFPYPVFWTEVYDENADIWYSVECMTLNCVISSDRSFFIPNTKALNKTKMNVSYIVAFEVDEYAKDVTFRYLNNMSTFSRVKLTTLERDKYTSFEKLVDIFKRPVLSDIDLKENNDLQPKNLSKKIQNITINDYKTHPTYILERHLKRQEVVRPGVSPVYVFMLGKGNKLKEERVFNRSDILLCKSVECYYREGRQIKSGELPLKIVKPRSVTLSRKRENELIAFETNKLAIQPLYAEFQTELYIPPPVVNGIVPKNGYGNIDVFVDSMIPKGATHLPYHGIGRIAKKLGFDYSDAVTGFEFKNQRAIPIITGILIATENASTCFEAWIFDEQKKIEKEIKKREKEILYRWKKFLLGLRIRNRVESLYGNSSNVLSGFIFSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7P2L1</accession>
    <name>M7P2L1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mitochondrial import inner membrane translocase subunit Tim21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_03563</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TIM21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875656.1">
        <property type="nucleotide sequence ID" value="XM_007877465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P2L1"/>
    <dbReference type="STRING" id="1069680.M7P2L1"/>
    <dbReference type="GeneID" id="19897250"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03563"/>
    <dbReference type="eggNOG" id="KOG4836">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1180639_0_0_1"/>
    <dbReference type="OMA" id="HFHVEGP"/>
    <dbReference type="OrthoDB" id="436405at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.320">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit Tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013261">
        <property type="entry name" value="Tim21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038552">
        <property type="entry name" value="Tim21_IMS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032:SF6">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08294">
        <property type="entry name" value="TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="235" mass="27760" checksum="12FEABEF6876D1B9" modified="2013-05-29" version="1">MYSRSFNFCTKGLWNSRNGIVQISNQFRYIRLYNTDRFLNLIQILKKDKGKIFLFFRDDTTKSWGQLHFMEKATRVVLISLKLSVIIVGVVVLSLASYSLGSYLFVVEAPAINMSLEYIKNNEECKRLLGNNIKVFSGSLQNSIRRNSYIPSQRIIEPDGREQIIMRFYVRGEKSQGEVSLKMIRKTFEESFQYQYLYLDVIVDNSLRRIWLIDVNKAKNEMKKNNFLLRFWGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M7P2R4</accession>
    <name>M7P2R4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease H2 subunit B wHTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875423.1">
        <property type="nucleotide sequence ID" value="XM_007877232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P2R4"/>
    <dbReference type="STRING" id="1069680.M7P2R4"/>
    <dbReference type="GeneID" id="19897031"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03344"/>
    <dbReference type="HOGENOM" id="CLU_1332424_0_0_1"/>
    <dbReference type="OrthoDB" id="29098at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019024">
        <property type="entry name" value="RNase_H2_suB_wHTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09468">
        <property type="entry name" value="RNase_H2-Ydr279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuclease H2 subunit B wHTH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="206" mass="24269" checksum="55CFBACF2A7591B1" modified="2013-05-29" version="1">MDDILDLFSEYHFPILISSLGPQMKHAIRSICHELDSSPSFFRFDESLLLKIMRTKVKKVASHLPKSIEFEAITKNFMDNIQGKELNSEKKPNELRKIIQLARIKTAMQLINNYLPIKYANLLLQSEDFTPLSLYLQKLQTHRASTLFIQNINHFTTDFYLKKDTVPKEKNKNKRSFENDNTRIQKKMDTKQINKITSFFKIQNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M7P336</accession>
    <name>M7P336_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875498.1">
        <property type="nucleotide sequence ID" value="XM_007877307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P336"/>
    <dbReference type="STRING" id="1069680.M7P336"/>
    <dbReference type="GeneID" id="19897099"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03412"/>
    <dbReference type="HOGENOM" id="CLU_713941_0_0_1"/>
    <dbReference type="OrthoDB" id="5370802at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018857">
        <property type="entry name" value="TORC1_cplx_su_TCO89"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10452">
        <property type="entry name" value="TCO89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="387" mass="44123" checksum="8BB5C3F12955EFBE" modified="2013-05-29" version="1">MADLPSKYPQNTLLLNRKTSSSVSSGEDLHAPRQAKLHKTFIVHGRHHTRVPSYGRNLNKTCRHSASAVSEVPSLLVKSKSSVSCDDLLKKSELLVKKENIEKNAENTERTPKEQLHIEDEKEKHIEPLKEAEQRENFESLRENVFSSVNITISSLEKKDDFNEEYVDKSQAEHITKRLVSMTNNQVAVPYLTCETAMAKNIPTTQLTSTKEFSCILPSSDNLGKTSTKSSVEPPTSNVLKYAASDPLFRNPISRTQQKLLLQRESSLSSVKSQSNKDHDYCEFIQHRINRINKEYSNILRLSDPLKHVILKLFNDGCLEEVKNIPSSLNHKTAEEKLPKNTSKFVDLIGKRENVFKESDKSKIEYDDMLSIQIILEEMWKSNENIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3Z8</accession>
    <name>M7P3Z8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_03061</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875117.1">
        <property type="nucleotide sequence ID" value="XM_007876926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P3Z8"/>
    <dbReference type="STRING" id="1069680.M7P3Z8"/>
    <dbReference type="GeneID" id="19896748"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03061"/>
    <dbReference type="eggNOG" id="KOG3275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_3_0_1"/>
    <dbReference type="OMA" id="YHAEFMH"/>
    <dbReference type="OrthoDB" id="672793at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039384">
        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="7"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="95"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="137" mass="15311" checksum="957040AC0C422561" modified="2013-05-29" version="1">MIVSKCIFCRIILGELPAYKLLETEKSLAFLDIQPLSRGHALIIPKEHAEKLHELNDDFLADILPIAKRLANAMGLEQYNLLQNNGSLAYQAVFHVHFHLIPKPSSSEGLYVEFKSANSVGSDLLESVAQTIRDKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M7P449</accession>
    <name>M7P449_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pescadillo homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Nucleolar protein 7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NOP7</name>
        <name evidence="6" type="ORF">PNEG_03116</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pescadillo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875172.1">
        <property type="nucleotide sequence ID" value="XM_007876981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P449"/>
    <dbReference type="STRING" id="1069680.M7P449"/>
    <dbReference type="GeneID" id="19896803"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03116"/>
    <dbReference type="eggNOG" id="KOG2481">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019619_1_1_1"/>
    <dbReference type="OMA" id="QKVTWIV"/>
    <dbReference type="OrthoDB" id="10264910at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17709">
        <property type="entry name" value="BRCT_pescadillo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000002">
        <property type="entry name" value="Pescadillo homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03028">
        <property type="entry name" value="Pescadillo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010613">
        <property type="entry name" value="PES"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221">
        <property type="entry name" value="PESCADILLO - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221:SF6">
        <property type="entry name" value="PESCADILLO HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06732">
        <property type="entry name" value="Pescadillo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BRCT" evidence="5">
        <location>
            <begin position="348"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="540"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="568" mass="66495" checksum="2562227DA746DFA9" modified="2013-05-29" version="1">MTKIKSKGKSGAAKNFITRNQALKKLQVTLADFRRLCIFKGIYPREPRNKKKANKGSTAPVTFYYSKDIQYLLHEPIIDKIRQYKIYIKKFNRALTHKEYEIVRSLEENKPFYTLDHIIKERYPTFLDAIRDLDDALSMLSLFSSVQVTEKIDSTIISNCERLCLEFQNYVIVSKALRKTFLSIKGIYYQVEIKGQEVTWLVPYKFSQRIPVDIDLRIMLTFLEFYQTFVGFINYKLYTDSGLTYPPPVNVSLFEEAGDISAYNLEKLTTIQTENQLEGNKRPKDIKKQISTLDKKLDKISEETNFLINDDLKISENIADEAVLDNFSLHNNSDDSNKLIQPVTASSTEVNIFEKFIFYLSREVPRYSLEFVIKSFGGKVGWDPVLGSGSLFKEDDMTITHQVYDRPTLHKKILNRIYIQPQWVYDCINKKKILSTNEYAPGSLLPPHLSPFVKIEDEGYNPEAEEDYDVKEQDESNNIDMNDYEKKDIQDSSLPFSYYIKKTKKSNETKETESEEIKDLSKVMLTNKQRKLYKKMIHSNLKKKEEIDRLKKRRKELIQKNKKNMLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7P4Z7</accession>
    <name>M7P4Z7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SP-L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02702</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL3 plays a role in coordinating processes of accommodating the aminoacyl-tRNA in the PTC.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 33 different proteins. The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and at least 46 different proteins. uL3 forms together with ES39L one of the contact sites for the signal recognition particle that targets ribosomes to the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874726.1">
        <property type="nucleotide sequence ID" value="XM_007876535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P4Z7"/>
    <dbReference type="STRING" id="1069680.M7P4Z7"/>
    <dbReference type="GeneID" id="19896393"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02702"/>
    <dbReference type="eggNOG" id="KOG0746">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033361_2_1_1"/>
    <dbReference type="OMA" id="QRTEYNK"/>
    <dbReference type="OrthoDB" id="1611972at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990145">
        <property type="term" value="P:maintenance of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000079">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1430.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000351">
        <property type="entry name" value="Ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="entry name" value="Ribosomal protein L3, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00059711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00063215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00083825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="394" mass="45124" checksum="E13689BA3D16AF1A" modified="2013-05-29" version="1">MSHRKYEAPRHGSLGFLPRKRASRHRGKVKAFPKDDPKKPIHLTAFMGYKAGMTHVVRDLDRPGTILHKKEIVEAVTIIETPPLVVVGVVGYVETPRGLRSLTTVWAEHLSDEVKRRFYKNWYKSKKKAFTRYAKKYSEMNRPIARELERIKKYCTVVRILAHTQIRKTPLSQKKAHLMEIQVNGETVDKKVEWAREHFEKTVDVKSVFEQDEMIDVIAVTKGKGFEGVTTRWGTRRLPRKTHRGLRKVACIGAWHPSHVMWTVARAGQNGYHHRTSINHKIYRIGSGDDPRNASTDFDITEKRVTPMGGFVRYGAVENDFIMLAGSTPGPVKRILTLRKSLLTHTSRKAIEKVSLKWIDTSSKFGHGRFQTPAEKKQFMGVTKKDIMHASKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7P5K1</accession>
    <name>M7P5K1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874510.1">
        <property type="nucleotide sequence ID" value="XM_007876319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P5K1"/>
    <dbReference type="GeneID" id="19896192"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02500"/>
    <dbReference type="eggNOG" id="ENOG502S2WW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123426_0_0_1"/>
    <dbReference type="OMA" id="MILTWWG"/>
    <dbReference type="OrthoDB" id="2344991at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013879">
        <property type="entry name" value="DUF1761"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40638">
        <property type="entry name" value="UPF0591 MEMBRANE PROTEIN C15E1.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40638:SF1">
        <property type="entry name" value="UPF0591 MEMBRANE PROTEIN C15E1.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08570">
        <property type="entry name" value="DUF1761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="157" mass="17260" checksum="FA79405268783F8A" modified="2013-05-29" version="1">MFKGSLSALANDGNIPKICPTAVIVGSVFEHLTSYLVYGPFLGRTWQRAMILDKNTEFWASKKTVSAGLMYGVSFISSGIQVYAMAALLKLTGSFKYKSAFYLSTLVFAATTLPNIVSGYFVEKRPKEYVLVKFVSGLAQTVGLNFVLASYHLRCKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7P5W4</accession>
    <name>M7P5W4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YAG7-like dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874594.1">
        <property type="nucleotide sequence ID" value="XM_007876403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P5W4"/>
    <dbReference type="STRING" id="1069680.M7P5W4"/>
    <dbReference type="GeneID" id="19896271"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02579"/>
    <dbReference type="eggNOG" id="ENOG502S59W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1103170_0_0_1"/>
    <dbReference type="OrthoDB" id="5399559at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058602">
        <property type="entry name" value="YAG7_dimerisation_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26434">
        <property type="entry name" value="YAG7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YAG7-like dimerisation" evidence="2">
        <location>
            <begin position="27"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="252" mass="29834" checksum="F058309C66D4D8D9" modified="2013-05-29" version="1">MVQEKEAKQKEIEIARKIAMNEVEERKKEKEQVRTLVLFLKYASLTRHTPTNDAEYNRAVEKVLQMVYEADENSIQVVEKLYEGSEEQIEESKRITYKYMKEQIEQKAEEMQKSFEYRLEESQQQKMPSYNLQESLEQMTFNKPSKVISPSNKKTRGPYEKINFLNESEIEGLSLKDPLTTNYTRGSMDALTNALYNHYPVNNNMFSVASMTHYHEMQNPTSVSWKEPRLNHQSTQHWSTERRSPLPNHEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7P604</accession>
    <name>M7P604_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Striatin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_02599</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat striatin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874614.1">
        <property type="nucleotide sequence ID" value="XM_007876423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P604"/>
    <dbReference type="STRING" id="1069680.M7P604"/>
    <dbReference type="GeneID" id="19896291"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02599"/>
    <dbReference type="eggNOG" id="KOG0642">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009046_0_0_1"/>
    <dbReference type="OMA" id="SKCSQEV"/>
    <dbReference type="OrthoDB" id="727118at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013258">
        <property type="entry name" value="Striatin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF0">
        <property type="entry name" value="CONNECTOR OF KINASE TO AP-1, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08232">
        <property type="entry name" value="Striatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Striatin N-terminal" evidence="9">
        <location>
            <begin position="21"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="438"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="491"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="636"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="105"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR09265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="723" mass="82498" checksum="A0045447C28212EA" modified="2013-05-29" version="1">MLFQNILDERNNHKGEIAEYTLQGVIHFLQTEAYRYQRDRNYWEIEYAEMKAKISKLEGERKGLDRLKDLHLKRIKMLEDSLQKERLKSMNLLSPTTSSIKHTLLDQLSSKTKNNNKSNSPGKIAESDEIAKQEEKELHSKLFPESKISHDNLQQSTKRTKSRQFLEKCLQEITYLINSQPDILTDIPILYQTNPIQSHYIPLHNNSALTPISSSINTEESSQQNKSNLYDENIKISSNQFCQQKNKSFKAYDTDNIGNSIENNCSSHINSYPIILNKDIHDGKNQKNIYHYNEILISNLPSMSLSKTSEAHQKDNQIHKKKIEHGAIITDSQLLLDSCLQQRHMATDIKNSSWDFNDDNEFDEKIDENNQNTYAEWKTKFVLKNHLTNIRSVSMSKNENSGYASMATCGDDGLVKFWRLPINNKKIRNQDIIPQITYRGHSGIVTNVCIALEANKIFSSGIDSSIRCWKIPEPQRNIYAPIDDCTLPSIFAGHSNAVWDLSFQPVSSLLASISADGTIKLWDINHTDSSPLLSTLNFHGNNLNKSSSAIPTSITFLNNDIRKISVSWNNAIIRIYDIETGSCVLELRNDEIYDGTNDTQINKIISLSKENMLISGHENKYIRFYDINSAQCTYSMLGHLNAISSLDISPDDRILVSGGHDSSIRFWDMQFPQVCIQKISNHHTKAQEGVNDVSWWHGRDNTCQLEYVTSVGGDGIIKVNTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M7P876</accession>
    <name>M7P876_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873802.1">
        <property type="nucleotide sequence ID" value="XM_007875611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P876"/>
    <dbReference type="GeneID" id="19895525"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01831"/>
    <dbReference type="eggNOG" id="ENOG502RMUH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_953513_0_0_1"/>
    <dbReference type="OrthoDB" id="5364312at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="292" mass="32698" checksum="353889D75056087B" modified="2013-05-29" version="1">MTFWGKKKSKKIPGSKPDDNASSDLEKGSRKIDNKINSLETEKLPLAESLSTCSYEIKKKSFFKRICQNKKEEMLSRTPKSDEDIKNASIPKINVDTTIYSTSIRSPSHIYKNIQHASPNSSIFDKSHVFERSVDYSSLASPSTSISFTPSVYKINLIDSTHQQRMVDNHVPTVLDASMEILNDSTDMDNIEIVSIKRLCSPALSSDTFQPKDSLTSYTSSLYTRETSLSFVSYADLVNVDYCETSLPVLTLSDSSKMLAQRSDPEYVSLKQTLLGTEVKRLLSNTDNVSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7P963</accession>
    <name>M7P963_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_01638</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Interacts with pap1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the importin alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873594.1">
        <property type="nucleotide sequence ID" value="XM_007875403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P963"/>
    <dbReference type="STRING" id="1069680.M7P963"/>
    <dbReference type="GeneID" id="19895332"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01638"/>
    <dbReference type="eggNOG" id="KOG0166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018084_6_0_1"/>
    <dbReference type="OMA" id="EMIQMLY"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000021">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="9">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="7">
        <location>
            <begin position="124"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="7">
        <location>
            <begin position="166"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="7">
        <location>
            <begin position="335"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00064973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR10385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="552" mass="61237" checksum="9110423121D178D5" modified="2013-05-29" version="1">MSNLDTSRFVPEYRRNNFKSKNIFRIDELRRRREEQRLEIRKQIKEESLAKRRNLNLPLGLETTESDDEESALHLENQLNNELPLMIAGVFSDNIEEQIPATTKFRKLLSKERNPPIEKVIECGVVSRFVEFLKSPHTLVQFEAAWALTNIASGSSSQTQVVIEAGAVPIFVELLSSPEADVREQAVWALGNIAGDSPECRDFVLRAGALKPLLSLLTESRKLSMLRNATWTLSNFCRGKNPQPDWNTISPALPVLAKLIFSLDDEVLIDSSWAISYLSDGSNDKIQAIIDAGIPRRLVELLMHPSTSVQTPALRSVGNIVTGDDIQTQVIINCGALQALLSLLSSPKDGIKKEACWTISNITAGNCTQIQAVIDANIIPPLINLLANADFKTKKEACWALSNATSGGLSRPDQIRYLVSQGCIKPLCDLLTCLDNKIIQVALDGLENILKIGELDKENKGGLNRFALYIEEAGGMEKIHNLQQNSNQEIYLKSYNIIEKYFNDEDDIDSGLAPQVEGQTFSFGNIASNAEFPATQQFDFSNINTNGDTTMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7P9R9</accession>
    <name>M7P9R9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01323</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873249.1">
        <property type="nucleotide sequence ID" value="XM_007875058.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P9R9"/>
    <dbReference type="STRING" id="1069680.M7P9R9"/>
    <dbReference type="GeneID" id="19895020"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01323"/>
    <dbReference type="eggNOG" id="ENOG502QWQU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_275215_0_0_1"/>
    <dbReference type="OMA" id="LRYAWIH"/>
    <dbReference type="OrthoDB" id="2149224at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032065">
        <property type="term" value="P:maintenance of protein location in cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053005">
        <property type="entry name" value="Nuclear_Pos-Cytoskel_Interact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024774">
        <property type="entry name" value="PH_dom-Mcp5-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190:SF1">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12814">
        <property type="entry name" value="Mcp5_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="870"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="454"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1000"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1117"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="234"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1021"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1117"/>
            <end position="1133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1145" mass="132653" checksum="FD82A9FC7A4A6D27" modified="2013-05-29" version="1">MDTTQTEKALERQLQEVTTRIYSAGRLGERLLNQKKKIEEQLEVLEGVNRIPENLKAKLQELEREFEEIRKESNDSWLLLGSLDEVSTLDQQIKPNVPQFISNGTISPIKHGLSMRRRNNKPISRPHDIEFATEIGQSLLTEVRRLQGLLNEREEQWRAIIREKGYIEHEMEGLEAKLKTLGESEEKYKEENWNLELMTQEMAKEISRLSTSETRIMQENARLLKITQTQIETIETLKQREMELTEILEQLRIKHESEITSFRKAQEELLEERYEWIRQVEELKAERLALFETNDYHYKDIKKEEEWAKDDEEIISEIITPERLSPQSPIKCTPSRNVPLEVETIKASFSHAQRTIHRLRNAVQHEKTEKIELRHLLNEALEKLEKLERESAKISKRRSSRKSQYSTMINPYEYKEVTNEITIESDSEWKNEYDASRITINTPDSTECLRRNSYVEEKRDSRDLEDKISNHTKKTHLDNSDISQDSDNEIDTNKRNEYLYSRKKKEFSLDASRKIQPLFKELQIFSQNNYVETADIGTMTDEASDIMKIRNFLFNLNTIVAEKKPVSFVLNENGILQPNDNSLINIESNNPDTVPSTNLSKEINKIDATENNIELQSKPFSFSSLVSVFKLRKKKSTQMPSIFEINKNTSNLTLNKLNYNDTLLNNSQLNSNLTNDIKQEDKSNVILNNDNSNAILENKRDNFSNSKMLFNDQEATLLTSSSKFSENTTDQSLQIGPLKPQNRSEILKKLNTSSSSQIELNKDKYHTFNKMTHMKKPSFEFLLHDPASKKPNTSLSTSTDKETTYGTITIFNSVLASKGSLINTSVKSSSSSFSSTRNIENFQSQTNGHRVSTNTQPSIDPQIIRCITQTMIGEYLWKYTRKHARKELSHNRHLRFFWVHPYSRSLYWCKRNPSTSYGQESYAKSAFIESVRVVYDNNNYPKGIHNKSIVVITPTRAIKFTAGLSTSHELWYQALSYLTSQINPLTEISSNTVESIETKRHNLTSQQTTDDLDPLFKQSRDSSSTFVTSSNKSSSERKTSLQRHASLPKLNQIIRSGINSYSSMRIKKLPSKGYLLSEESHLEEKYKKINSIMRQTNMENVRACCNGKHDVGSLSYRSRSFSSESRQSRSPSRGYHVNLNTSINH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M7P9S3</accession>
    <name>M7P9S3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Required for respiratory growth protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01328</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for respiratory activity and maintenance and expression of the mitochondrial genome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRG9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873254.1">
        <property type="nucleotide sequence ID" value="XM_007875063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P9S3"/>
    <dbReference type="STRING" id="1069680.M7P9S3"/>
    <dbReference type="GeneID" id="19895025"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01328"/>
    <dbReference type="eggNOG" id="ENOG502S7IA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1496849_0_0_1"/>
    <dbReference type="OMA" id="ANKWILP"/>
    <dbReference type="OrthoDB" id="5578174at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010487">
        <property type="entry name" value="NGRN/Rrg9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475:SF3">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06413">
        <property type="entry name" value="Neugrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR10625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="180" mass="21925" checksum="26E70293525264D5" modified="2013-05-29" version="1">MFLRFFYKRNLNYKSSLLSKKTTDSSKNIQKRRNKWVLPSPLDHEEIKKKHLKNNTLSKTSYQSLLSLKNVTWKENKELPQWKKQKIALKEKFPEGWNPFKKLSPDTLNQIRTLRQQNPKYTASVLSEMYKVSPEAIRRILKSKWQPSFKEYADRFARWKKRKNRLKDIWISQKFKKDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7PA47</accession>
    <name>M7PA47_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nitrogen permease regulator 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872785.1">
        <property type="nucleotide sequence ID" value="XM_007874594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PA47"/>
    <dbReference type="STRING" id="1069680.M7PA47"/>
    <dbReference type="GeneID" id="19894573"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00875"/>
    <dbReference type="eggNOG" id="KOG3789">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014995_3_1_1"/>
    <dbReference type="OMA" id="IVMHKPD"/>
    <dbReference type="OrthoDB" id="338854at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009348">
        <property type="entry name" value="NPR2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991:SF10">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991">
        <property type="entry name" value="NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06218">
        <property type="entry name" value="NPR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="48000" checksum="C77E5E45A350116E" modified="2013-05-29" version="1">MDRKELMEGYEQDRECETFPTKIVAIFFAQFHPVQGPQIVYQVPPNAITLEEEVVDKEPLFEFEPISEYIIPKRKLCDRVVAICTNGYRILGHPICIVDRTYERNALIFNCALVFREKDDSSCYVPVVKRLAKVFKSLEEQGNFISKQKKRMIIYNIIEQIMEDLNNYCECMIPIDETNTINIKLFPTFSNPPKVLPHQVPILTVQLDLLMNVNWDLTVRKIVPFIDGINSVRRITELTNTDYMFVCRCMEHLLYYGCLIMVDIFKFSNMYAPTPNINMLIEDSALREECLAYISTRHDISLSFAFVFHLYCSLRQGITLKDWIIENRLSLSGIDIRRFISFGIIKGFLYRIHRYPFLAEPYNSQNIDESLLKYLDGTHNMDEICTETKKSVKEVKADLETLGKINYIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAK0</accession>
    <name>M7PAK0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylethanolamine-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872935.1">
        <property type="nucleotide sequence ID" value="XM_007874744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PAK0"/>
    <dbReference type="STRING" id="1069680.M7PAK0"/>
    <dbReference type="GeneID" id="19894720"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01022"/>
    <dbReference type="eggNOG" id="KOG3346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_702307_0_0_1"/>
    <dbReference type="OMA" id="FRTQWDE"/>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="46587" checksum="8BBBB578351A9E38" modified="2013-05-29" version="1">MRHSLQQIYNTFYKINRNFIYIRHFAFLSKDYLKKHPRERIQNRKPNFYLQIANITSKSNESLSNESQILSLQQDSHVFDIENGNKEKKYPRLTYFSPKLGVNKAYDEALKVIEADRLEKQKKIKKIKLKIEQMLKNKDSITKDTEEQIINLKKYLNQLEILADINDPEIRWRFKHNDVDMSIPVYRYLAEQKWMKKPYHLLMQRIEQMYVIPDAYKRFKPTVEVLLRFGKEELEPGKFVPNNISALAPVIEINSFSGKEELYTIILLDLDVPDLEKDSFKIYLHWLISNIPISPTNASVQPSKGTILASYIPPHPQKGSPYHRYTLLVFEQVKKISNDYNIIRNCFNVNQFASLNNLKIVGIHFWRSVWDEHVDKVMSDAQLPQYKTMLKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAP2</accession>
    <name>M7PAP2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="14">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PNEG_01076</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="14"/>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872987.1">
        <property type="nucleotide sequence ID" value="XM_007874796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PAP2"/>
    <dbReference type="STRING" id="1069680.M7PAP2"/>
    <dbReference type="GeneID" id="19894773"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01076"/>
    <dbReference type="eggNOG" id="KOG0202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_3_2_1"/>
    <dbReference type="OMA" id="PLWNNMM"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000003">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000005">
        <property type="entry name" value="Calcium-transporting ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000027">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000037">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000014">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005782">
        <property type="entry name" value="P-type_ATPase_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01116">
        <property type="entry name" value="ATPase-IIA1_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 14" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="11 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="753"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="786"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="827"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="923"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="15">
        <location>
            <begin position="3"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMR10930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="995" mass="111158" checksum="14574AA0AD129623" modified="2013-05-29" version="1">MECAYNFKAEDVLMHFGVNESQGLSSKEVFLTRQKYGKNELEKDGGRKLWVLIMEQFKDKLVIVLLISAIISFILAFFGSDKNNTDFMDPFVILAILIINAIIGISQETNAEKAIAALQKYSPNEAKVIRNGKISRIHARDLVPGDIIDVSIGDRIPADCRLLKIKSNNFRVEQSILTGESESVEKCTDKIHIHNPTKQDQTNMLFGGTTVTTGHARAIVVLTGKSTAIGDICQNITSQISELTPLKYKLNNFGDILAKVISLICVLIWIINIKNFNDPLHQGFLKGAIYYFKTSVALAVAAIPEGLSVVITICLALGTRKIAEKNAIVRNLSSVETLGSTSVICSDKTGTLTTNIMCVSKIIILEQDESLLEFNVEGTNFNPFGNIYLNDGTIMKSPAFIYKSIKYLAEICSVCNDAKIIFDSNLNTYTRIGEPTEAALKSLVEKLGTDIEDIKPKHNLSYNDSANSCNIYYNTLSPRLKTFEFSRDRKSMSVVVGNIESPRLLVKGAPETILERCSYTIIGKSGQKIILTTNILSKINKKIAEYGLKGLRIMAFAQVDSKDFKAHPFHTKVSNNYEDYEQNMTFVGLVAMLDPPRPEVANSIAKCRSAGIRVICITGDNKKTAETICRQIGIFKKNENLEGKSYTGQEFDNLSPAQQLEAVKRANLFSRTEPAHKVQLVKLLQQTGEVVAMTGDGVNDAPALKKADIGIAMGSGTDVAKLTADMILIDDNFSTIEHAIEEGRAIYSNTQQFIRYLISSNIGEVISIFLTVLLGIPEVLKPVQLLWVNLITDGLPATALSFNPIGYNLMKRPPKDKNEPIVNLWLFIRYCITGGYIGASTIFGYIWWFVYYFKGPRITFKELSRFHRCSDTNPCYWFNNYTSSKASTISLSILVVIEMMNATNSLSQTESLLSLPLWTNIKLVYAIILSLLLHLAVLYVPYLQKIFSTIPLNWIEWKMVTFISLPIIFIDEILKFAERIYIKDFSNNKKNQKYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAQ5</accession>
    <name>M7PAQ5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DUF1640 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_01090</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCDC90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873002.1">
        <property type="nucleotide sequence ID" value="XM_007874811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PAQ5"/>
    <dbReference type="STRING" id="1069680.M7PAQ5"/>
    <dbReference type="GeneID" id="19894787"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01090"/>
    <dbReference type="eggNOG" id="KOG3156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063283_2_0_1"/>
    <dbReference type="OMA" id="MAYMRFR"/>
    <dbReference type="OrthoDB" id="889336at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000214">
        <property type="term" value="P:regulation of L-proline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000018">
        <property type="entry name" value="Mitochondrial protein FMP32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024461">
        <property type="entry name" value="CCDC90-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360:SF1">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07798">
        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR10945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="25753" checksum="C2BF5F26933271CE" modified="2013-05-29" version="1">MIQWKQMLFCIFQTIRAVPKPYNYLSLSICHFSTQTYKARRYFDTLQLVKQLEKEGFTKQQSLAVMQALQAVLEESFHDLTKTMVTKEEQERISYTQKVEFSQLRSELQTLEKNDLTSTRQEYDRILADLEKLKRIFREEINHTLANVRLDLNLEKGRIRDEYTAHELKIKETDTRIENEINNIKTQAETIKLQIFQWLIGIITGGGALVLAYIRLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAS2</accession>
    <name>M7PAS2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_00569</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR10965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872463.1">
        <property type="nucleotide sequence ID" value="XM_007874272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PAS2"/>
    <dbReference type="STRING" id="1069680.M7PAS2"/>
    <dbReference type="GeneID" id="19894267"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00569"/>
    <dbReference type="eggNOG" id="ENOG502QSWP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025694_1_2_1"/>
    <dbReference type="OMA" id="QQSFKGY"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007117">
        <property type="term" value="P:budding cell bud growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR10965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="403" mass="45759" checksum="18A77AE16458CEAF" modified="2013-05-29" version="1">MYYFSGTPGLFKGPVYWWQSGAAWNSLLDYSRYTGDKKWNKLIIEAILSQAGENRDLLPIQFRLSQGNDDQTFWAFTAMTAAETNLENPPPNEPQWLELVQAVFNEQVERWDEQNCRGGLRWQIFPYNLGYTYKNTVSNGAFFQLAARLARYTNNETYARWAEKAYVWMEDIKFINLTTYAVYDGAETPNCYPVTRVQWSYNNGLLMAGSAFMYDFTKDPKWKDRVYRYIFKAKKSFYRNNGILCEPACEFIKTCNQDQMSFKAYLSRFMGYTMNLMPDTISHILPLLKSSSIAAAGACSGPPSGHHCGMNWQASNYDGWDSLGSQMSALETMLAILAPNAMKPLTSDTGGTSKADPNNVYRDRSLYFSSDIRPPTIADKACAGLLTVLVVIGALAFFAWLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7PB13</accession>
    <name>M7PB13_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00667</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872567.1">
        <property type="nucleotide sequence ID" value="XM_007874376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PB13"/>
    <dbReference type="STRING" id="1069680.M7PB13"/>
    <dbReference type="GeneID" id="19894365"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00667"/>
    <dbReference type="eggNOG" id="KOG0594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_6_1"/>
    <dbReference type="OMA" id="FELWTVF"/>
    <dbReference type="OrthoDB" id="413582at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF576">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CSK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="4"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR11070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="300" mass="34452" checksum="A4AF36CFD84712A9" modified="2013-05-29" version="1">MNEFKEKSFHSEGTTGKIYRSIWSTRGDRVVALKISTLSINRMPHRPDYEIQLLEELKHENIVESLGSFRYGENHVLVLPFLPYDLLSIIKRGNKDENWLKEQIKGITSALVYIHDKGILHRDIKPENIMFLSENGKAVLIDFGIAWSYKNPGNEIQGKLITDVATGPYRPPELLLSYTNYGTSLDMWSWGVTIAQMFTFENKPLFDSGLGNNFGYSDLLLLSSIFKTLGTPTKDNWDEIDDLPDFKKVHFVHYDPQPWETILPNAPSEARDLISNLVTYSFKKRLSAKDALNHSYFLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>M7PB55</accession>
    <name>M7PB55_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase kinase kinase</fullName>
            <ecNumber evidence="2">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_00717</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872617.1">
        <property type="nucleotide sequence ID" value="XM_007874426.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PB55"/>
    <dbReference type="STRING" id="1069680.M7PB55"/>
    <dbReference type="GeneID" id="19894415"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00717"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003051_1_2_1"/>
    <dbReference type="OMA" id="TINARWQ"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd09534">
        <property type="entry name" value="SAM_Ste11_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06628">
        <property type="entry name" value="STKc_Byr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000334">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029458">
        <property type="entry name" value="Ras-bd_By2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14847">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01304">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM" evidence="12">
        <location>
            <begin position="10"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="13">
        <location>
            <begin position="183"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="545"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="574"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR11120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="822" mass="93068" checksum="EC32F3FB16C5800B" modified="2013-05-29" version="1">MNYLNEVKLWSEEKVGEWLKSNNFGDYVDIFKENNVNGDILLECNAALLKELGIKKLGDRIKLSVCIKKLREKCIESARKAKMSFLMIDNRISEFPFTSQSPTDPLIPVKSGDLISPTSNFQLDNPYNDACCFDSLNNSHSFLSNASHSTKSLSKDSFTSTQRVFEKSPIFSEINIMQSNSIKKNCLKFIGEKGQTRIVNISRCHTAEAILSKALKKFNIIEDPSEWRVFITNEDGSFECISNDTLLTISRQLSRPERERLILKRKSDPLTLEEFRKSQTIAREQQDAIYHTAVMAKTSGNLRKLETFFGEKLTPTFTSSFTTPLPSPLPKDNKYGNIKHIRNFFGQRPPSELINSNLAEYFPGHEKKVLEQTIKNSIKSTHLNSFRGPNFSTSSSTLAYDISSIPTVGEAWIQFEGQRLSEIGRTFSLSRFISTRFPTLLESSILKENSSHHTLSLSKSNTEDNTQDIKPIFCKKSEEKAFPNETFKSESPNVLGEPLILSDIYNTSLETARDVLDDNIFENNENKDFNFEKEVENNNTGPTRWIKGALIGSGSFGSVFLGMNALSGELMAVKQVEIPSFDIQGCKRKKAMLDALQREISLLKELHHENIVQYLGSSMDETHLTFFLEYVPGGSVTALLNNYGAFEEPLIRNFVRQILKGLNYLHNKKIIHRDIKGANILVDNKGGIKISDFGISKKVEANLLSMTRNQRPSLQGSVYWMAPEVVKQTLYTRKADIWSLGCLIVEMFTGEHPFPKMNQLQAIFKIGQYVSPEIPEHCTSEARHFLEKIFEPDYHARPTAADLLKYSFLGPMVSSPLTDAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M7PC01</accession>
    <name>M7PC01_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872311.1">
        <property type="nucleotide sequence ID" value="XM_007874120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PC01"/>
    <dbReference type="GeneID" id="19894131"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00433"/>
    <dbReference type="HOGENOM" id="CLU_2004865_0_0_1"/>
    <dbReference type="OMA" id="REDCEWI"/>
    <dbReference type="OrthoDB" id="5306256at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="124" mass="14558" checksum="C66184B3CD02F883" modified="2013-05-29" version="1">MSVNSTKLEEPKNEASIIEIKKTNNILDVLPRFDVDIMTAAYMSTMEIINEEEDLLFTEYKELCQELQSWIRSRIVYDHLMTRKRIRLTVDWVIAKEEELEKTRKEILGCMEAVKKALGLLFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCU7</accession>
    <name>M7PCU7_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00159</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat TRM82 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872020.1">
        <property type="nucleotide sequence ID" value="XM_007873829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCU7"/>
    <dbReference type="STRING" id="1069680.M7PCU7"/>
    <dbReference type="GeneID" id="19893857"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00159"/>
    <dbReference type="eggNOG" id="KOG3914">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_667571_0_0_1"/>
    <dbReference type="OMA" id="CVWDTKD"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106004">
        <property type="term" value="P:tRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03056">
        <property type="entry name" value="TRM82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028884">
        <property type="entry name" value="Trm82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288:SF0">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT WDR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288">
        <property type="entry name" value="WD40 REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="366" mass="41951" checksum="B65D3B70B5CBB32E" modified="2013-05-29" version="1">MRHPIQLILANTKKEEIYIGVGKNVYILDSKTGKNLANWTLPEANNVQLKETPINQIQCMNLSAEKDLLFISSNDKLLRIFDISEGLKIQNEIRCNKRPCVITVVEKLSKVFVGDKFGDVYSFLLNENSTVETNTGPIPPNLVLGHVSMITDMIVTKDSNYLITSDRDEHIKISCLPKCVVIKGYCLGHQEFVSKLSILSWNPDILISGGGDPYLFVWNWRNQELLSKIDLIKLLYKKDQKKYVLDNEKIAIIGIQQISTRKEIAIIIQKIQLLFIFGDLASEKPILKIIEPLPGDPLSITLDKNDVLWISLDNSTDYNIPFIYLYPKNEDFKKIVQEIDKTISIEVDYKFSPLYDFLQIRKSRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCZ2</accession>
    <name>M7PCZ2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Eukaryotic translation initiation factor 3 subunit E</fullName>
            <shortName evidence="4">eIF3e</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">INT6</name>
        <name evidence="8" type="ORF">PNEG_03155</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the eIF-3 subunit E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875217.1">
        <property type="nucleotide sequence ID" value="XM_007877026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCZ2"/>
    <dbReference type="STRING" id="1069680.M7PCZ2"/>
    <dbReference type="GeneID" id="19896842"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03155"/>
    <dbReference type="eggNOG" id="KOG2758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031132_0_0_1"/>
    <dbReference type="OMA" id="NCPWILR"/>
    <dbReference type="OrthoDB" id="417252at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070196">
        <property type="term" value="P:eukaryotic translation initiation factor 3 complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21378">
        <property type="entry name" value="eIF3E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03004">
        <property type="entry name" value="eIF3e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016650">
        <property type="entry name" value="eIF3e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019010">
        <property type="entry name" value="eIF3e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10317">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09440">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21357">
        <property type="entry name" value="EIF3E_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016255">
        <property type="entry name" value="eIF3e_su6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01186">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="240"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="456" mass="53856" checksum="A436D4B9C6E4DE8B" modified="2013-05-29" version="1">MIDESDNTASVESFHPSQYDLVPRMLPYLDKHLIFPLLEFLQQKKIYPNKDLLREKYNLLIETYMTDYIINLCQEMTTEDPTFKSQIELDKKKEEEEKEFSKLNKESQKVLEVLENHEIITALRQDKAQNLQYLKDTHGITVEMINVLYKLGEFQYNCGNYTSAVDLLYHFRALSMDNDMNISATWGKLASEILTVNWERAMEEINKLKDIIDTKSFSSPVFQLKHRTWLIHWSLFPFFNHEAGKEALCELFFLPPYINTIQTACPWILRYLTVAVVTIRSRSRNAMSYQRRIKELVKIIDQELYEYTDPIIEFINALYIQFDFEVAQNNLKEAEKVLKNDFFLVATCSDFINSAHYLMIEAYCKIYQRINIDDLSKRLNFSHTEIVKFIHDDIVDLNAKIGFEEGIITMNHPSQPIYQQIIERTRGLNFRTQVLTQTITRRQQGDKKEAIHEIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7PD09</accession>
    <name>M7PD09_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome c oxidase assembly factor 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_03174</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875237.1">
        <property type="nucleotide sequence ID" value="XM_007877046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PD09"/>
    <dbReference type="STRING" id="1069680.M7PD09"/>
    <dbReference type="GeneID" id="19896861"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03174"/>
    <dbReference type="eggNOG" id="ENOG502S7HF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142408_1_0_1"/>
    <dbReference type="OMA" id="CAKAWVK"/>
    <dbReference type="OrthoDB" id="5545577at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.140:FF:000003">
        <property type="entry name" value="Cytochrome c oxidase assembly factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048281">
        <property type="entry name" value="COA6_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="10031" checksum="D91B764771361FBF" modified="2013-05-29" version="1">MISIVNIPPTKSQRERCWEARDIFFQCLDKHSIVNPMTQIEKIHSLCSSEEENFRNNCAKSWIEYFKKKRVIDFQKGFYEKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7PD29</accession>
    <name>M7PD29_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tripeptidyl-peptidase 2</fullName>
            <ecNumber evidence="3">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_03199</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875262.1">
        <property type="nucleotide sequence ID" value="XM_007877071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PD29"/>
    <dbReference type="STRING" id="1069680.M7PD29"/>
    <dbReference type="GeneID" id="19896886"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03199"/>
    <dbReference type="eggNOG" id="KOG1114">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003084_1_0_1"/>
    <dbReference type="OMA" id="SLRDFQC"/>
    <dbReference type="OrthoDB" id="10256524at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04857">
        <property type="entry name" value="Peptidases_S8_Tripeptidyl_Aminopeptidase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000003">
        <property type="entry name" value="Tripeptidyl peptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034051">
        <property type="entry name" value="TPP_II_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046939">
        <property type="entry name" value="TPPII_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048384">
        <property type="entry name" value="TPPII_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048383">
        <property type="entry name" value="TPPII_Ig-like-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022229">
        <property type="entry name" value="TPPII_Ig-like-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046940">
        <property type="entry name" value="TPPII_Ig-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF14">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12580">
        <property type="entry name" value="TPPII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21316">
        <property type="entry name" value="TPPII_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21223">
        <property type="entry name" value="TPPII_Ig-like-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="11">
        <location>
            <begin position="42"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl-peptidase II first Ig-like" evidence="13">
        <location>
            <begin position="534"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl-peptidase II galactose-binding" evidence="14">
        <location>
            <begin position="667"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl peptidase II second Ig-like" evidence="12">
        <location>
            <begin position="790"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="167"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR08359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1239" mass="140652" checksum="13ABFA3583561D5E" modified="2013-05-29" version="1">MTELLLSSFLNDSVYSFPVKGLLPKDETESLQFIKKYPEYDGRGVTVAVLDTGVDPSAPGMQKTTDGKTKIVNLIDCSGSGDVDVTTVAEVFEEDEVLKTKGLSGRTLKISKEWKNRDGKWFLGIKRGYEFFPESLVTRLKKKRLETFNQQHTALLAHVQHHINLFKEEHKDESKLLKEEMDLKQDLEAQYDVLKDMMCNYDDPGPVFDCLVWHDGKNWRAVIDTDEDGDLTHKKPMCDYHIEHHYEYFSKQDMLCYSVNIYDNGSVLSLVTLCGSHGTHVSGIIGANHLDDPDLNGVAPGVQIVSLKIGDTRLGSMETNHSLLRAAIAMVNLGVDIANMSYGESTGINDAGIFIDFLRKIIIGKKDIIFVSSAGNSGPALSTVGAPGGTTSGVISVGAYVTASMIKAEYSIFENVPEGKYTWSSNGPCTNGAKGLTIYAPGAAITSVPTYVLSRSQLMNGTSMSSPSACGGISLILSALKAQKIKYTPPRIYKAIENASKNVCDIMNVGFLQVEKSYDYFIQYINFLDQDFDFEIIVNNSSFNGKGIYLREFEETNHLHQITVEVKPTLKDEEILEKNTLELRLVLLSSKPWVKVPNYLLLNATGRVFDVQVDPVVLSSGFHYAEIIAYDTIVPKRKIFTIPVSVCKPELILKSLISWKNILLASGYIERKFIRVPDTSNWAELRVRTKKIDTCIKIFIHFTQLVQNLRLKDTEHKFFLKLHQNELILKQFVVIPGTTMEVCFANFWSSIASGEIDVELEFHGLKLSSNKVNLMFSENSQSIKRIEVINTLAPEIFEPTLKLNSLRRTFYPSFSSIRPLGERDVFPDSKTLFEMILTYSLKFLENTEVTFFLPLSSSLYDSSFCMLTALFNRNKRLLHFGETEPIKTKLKAGEYVYRVQLVHDSILILEKVKNMTLSVIQSLGDSKELSLNIFNDHIDAFNKEKSQDFNMKLQQGDRKSVVISTFIDPKQLPKDAKNGDKLIGQLHLEDKTRNVKKAGYDVEISLILEPKESVPSKDESIIDFQVQVLNKIKDNEEKKKFLDDLLRLYPNELSVLNARLETILKFASDEEIIDAANAIFAYVDFEKIAEYIRSEQFSNINLSNDQKKEKEKWERQKSVLVKALQEKAKILGRTSDGILTKEFDDAFEECRKWMEFPGKDYDFFLLQVRRFIARKHYGLALQLILKLESDSSYDLNESEIAKVYELKIDILKTLDWSIWVTYQEKWKLILNPPKGYILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7PD48</accession>
    <name>M7PD48_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homologous-pairing protein 2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_03219</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HOP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875282.1">
        <property type="nucleotide sequence ID" value="XM_007877091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PD48"/>
    <dbReference type="STRING" id="1069680.M7PD48"/>
    <dbReference type="GeneID" id="19896906"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03219"/>
    <dbReference type="eggNOG" id="KOG4603">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063266_2_1_1"/>
    <dbReference type="OMA" id="QKYHREW"/>
    <dbReference type="OrthoDB" id="272266at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120231">
        <property type="term" value="C:DNA recombinase auxiliary factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120230">
        <property type="term" value="F:recombinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010774">
        <property type="term" value="P:meiotic strand invasion involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010776">
        <property type="entry name" value="Hop2_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040661">
        <property type="entry name" value="LZ3wCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938:SF0">
        <property type="entry name" value="HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938">
        <property type="entry name" value="TBP-1 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18517">
        <property type="entry name" value="LZ3wCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07106">
        <property type="entry name" value="WHD_TBPIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homologous-pairing protein 2 winged helix" evidence="9">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine zipper with capping helix" evidence="10">
        <location>
            <begin position="155"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="85"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR08379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="219" mass="25436" checksum="2AE75F1E14BFE395" modified="2013-05-29" version="1" fragment="single">MTKSKPQSNKRDDETLVLDYLRKTNRPYSATDICLNLHNAIPKTALAKILTTLSERGEIRCKTYGKQSVYVIDQEQFENPSSEELAIMDTRIEELRQQINETQEKNKQMKQALQSLMVQKTTAELQTMSKDLDQRITTLNNRLNSLQSGTARLISLEEKEIIQKNYEHMRKMWKDRKTLFRNLWDAISEGESSPAELKERLGIEDDVIDFNIDPLSGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7PD68</accession>
    <name>M7PD68_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hpc2-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_03236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875302.1">
        <property type="nucleotide sequence ID" value="XM_007877111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PD68"/>
    <dbReference type="STRING" id="1069680.M7PD68"/>
    <dbReference type="GeneID" id="19896923"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03236"/>
    <dbReference type="eggNOG" id="ENOG502RG9A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_771876_0_0_1"/>
    <dbReference type="OMA" id="AYGPSIN"/>
    <dbReference type="OrthoDB" id="5576775at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014840">
        <property type="entry name" value="HRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08729">
        <property type="entry name" value="HUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hpc2-related" evidence="2">
        <location>
            <begin position="185"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="359" mass="40736" checksum="2165199E0B24B33A" modified="2013-05-29" version="1">MSENQTTNEESKSSELSPEAHIPSGIIDESADNKEKENVPTVYEKEKQLATPSYSKSILTFSQSKNTSPTSTKTNTNKVLSDNFICYKEKPSIRIHVPLKGQVNVYVNFAREAEKQYGWTALHPLQATNLVKLGMLKFDNELDSDEGDESESNVDDDRKFKLSATHTENENSNLQEPFIPVPKKRKRRIQEEEYDTLDPFIDDSELFLEEIAASKDGFFVFSGPLIPKGDKVKIERTDESTKKGRSRGGKQNANRMINKNTKPKEAKSPKENNGKKNVKTIQNTKHTEQSENKKSAHLEKTIEKKEPKELKANKNLTPAKENLESNSTKSVNETKENKDTTTQKSKKSKKIEKPENEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7PDB0</accession>
    <name>M7PDB0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RecF/RecN/SMC N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_03275</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875347.1">
        <property type="nucleotide sequence ID" value="XM_007877156.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PDB0"/>
    <dbReference type="STRING" id="1069680.M7PDB0"/>
    <dbReference type="GeneID" id="19896962"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03275"/>
    <dbReference type="eggNOG" id="KOG0250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009063_0_0_1"/>
    <dbReference type="OMA" id="FMCHRSL"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="14">
        <location>
            <begin position="92"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="307"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="397"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="731"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="939"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR08444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1128" mass="130530" checksum="C1449086BB10FBA7" modified="2013-05-29" version="1">MVKRKIEDEKLFNEGNHRIFLDEKKYKSKVSLLDQGILNEDNICENESDNESQYNENENNENESSDGESKSQRVDLDMQNRRLLPCAEAGIIKSIELVNFMCHKYLKVDLCSNINFLVGHNGSGKSAILTAITVCLGGKASITNRGSNIKDLIREGANSSSVTIMLKNTGNDAYMHNVYGDTIIIERRFTRESCGGYKIRSADNRVISTKRDELNAINDHMGLQVDNPMTVLTQDTARQFLGSSSAEDKYKFFMKSIQLTQLNNDYNLVNESIEITANVIKTKKEGLFSLKQTLQDASARFQETFKIREMYEKLDNLKDEMAWAQVEEQEKRLDDITNLLENQRKKMLRAQEEYLKSESDLSNLSVKIAATQRNFDSIKEDKLPFSNQQYYEIKHRFDLNNEEIKELMIQQRELQDQIKIANNEITTCLKKISDEKGRRLELDGGCLEKLRKKKEELDLQISTLRSDNFKIDALIEEVGENIRIEGNKISKIKDTILVHDRSLKVLRDQLMSFEHAKKDRLTAFHPRMPMLIQAIEQENRFISVPIGPFGKFVQVLKPEWLFILETFFGTTLNAFLVKNTEDEKILKNLMQKCNCFVNIIIGTDDMFDYSKGEPDCEFDTILKILSIKDELIKRQLIIHHQIESTILIKDRFTADKIMYNKPANVTACYSLHKNGCDGFKIGGKRGSSSSIPVDGWKKALRLSENTDKEMLLIQKSIENAELEYNRSLQIQKLYMTSLKEMESKKKDLENQKKSIKHQINEKQNELDDINERFNEKENTGKIEALEENIKEAQEIVENYQGQYGDILKATNKLNEMNVLVKEELASKKKQISELETLIEQLKKVLEDFVGQRIQKKVDSEHYKKKVDEYLIKINEITENKVEQEKLVNEFIKKASQISKKVKVNHDAHYLDALIKQMTKRLSEAQQYLGATVEDIAQEFEKAQNDFDVASLEIKELEALYDILRNTLKERRQRWKYYRSMLSLRTKMLFHHFLSMRAFNGKLKIDHKARTLEPSIYVDAFSNEKNLLKNNTSRSLSGGEKSFSTVCLLLSIWEAMGSPIRCLDEFDVFMDAVNRKISISMMINAARDASMTQFILITPQDMSNIATGPDIKIIKMKDPERNQTILDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M7PDL7</accession>
    <name>M7PDL7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome assembly protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_03039</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for efficient biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RSA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875091.1">
        <property type="nucleotide sequence ID" value="XM_007876900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PDL7"/>
    <dbReference type="STRING" id="1069680.M7PDL7"/>
    <dbReference type="GeneID" id="19896726"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03039"/>
    <dbReference type="HOGENOM" id="CLU_1886618_0_0_1"/>
    <dbReference type="OrthoDB" id="69550at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051898">
        <property type="entry name" value="Ribosome_Assembly_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028217">
        <property type="entry name" value="Rsa3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28127">
        <property type="entry name" value="RIBOSOME ASSEMBLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28127:SF1">
        <property type="entry name" value="RIBOSOME ASSEMBLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14615">
        <property type="entry name" value="Rsa3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome-assembly protein 3 C-terminal" evidence="9">
        <location>
            <begin position="63"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="135" mass="16027" checksum="E01426E9996088B4" modified="2013-05-29" version="1">MEKKRKKIIEDNNDILPPYISEFKDVLTSMPDERKILSYEKNNLQQTNGTTENDSLDTSYDLFEQHYMDVVAREFEDELDQLRRDPSFNPKEMPLLVSALKKGVNIFSQEEKKKVMESLMRKDEDESKDNPRYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7PDN4</accession>
    <name>M7PDN4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_03055</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875111.1">
        <property type="nucleotide sequence ID" value="XM_007876920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PDN4"/>
    <dbReference type="STRING" id="1069680.M7PDN4"/>
    <dbReference type="GeneID" id="19896742"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03055"/>
    <dbReference type="eggNOG" id="KOG0717">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009539_2_1_1"/>
    <dbReference type="OMA" id="RANHEES"/>
    <dbReference type="OrthoDB" id="5894at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051964">
        <property type="entry name" value="Chaperone_stress_response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="4"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="455"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="57642" checksum="36FCE60063124263" modified="2013-05-29" version="1">MLNCYYNVLGVDQRASLDDIKKAYKRLALIYHPDKNNNSQEATEKFSLIQAAYEVLSDESERRWYDTHRKEILVQNNKTSSSRSSFTAIRVEELMSFFNPTISKKMDDSSEGFYTKIRNLFERLASEELAYANEQVNNIEKLPSFGNGKSPYIPTVKEFYEKWSCFSTLKSFSWVDQYKYKNSERKAKRIMEKENNKLRKIAIKEFNDAVKSLVNFIKKRDIRVKIEKVSETDRQASLLASSKAQAEKDRALFHASLGVYDEQEWTKINTNIEEEQEEKEEKIFECIICKKSFKSEKQFIEHEKTKKHIRSVNIFKKILKKESEKLNINILEKEPESSDSVEEYFTGDDNFETYQEQDLNNLKQENYNKEHSSIDDEQSLQFSDEESDIKYNSETSFMEVQDYKDNLSKNVDSLSNILDQNLTIKKKENDITKNKSPKNPKTKGKKNKNLNNNNNTCTFCFENFSSRNKLFDHVRHSGHAQPLPQLKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7PEP6</accession>
    <name>M7PEP6_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874745.1">
        <property type="nucleotide sequence ID" value="XM_007876554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PEP6"/>
    <dbReference type="STRING" id="1069680.M7PEP6"/>
    <dbReference type="GeneID" id="19896411"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02720"/>
    <dbReference type="eggNOG" id="ENOG502QTY2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009538_0_0_1"/>
    <dbReference type="OMA" id="RQDFGNT"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF69">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 11-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="641" mass="74170" checksum="AA9212C9F902D3FD" modified="2013-05-29" version="1">MDGDVYLRRLVQFIRANESSLASSLENPTRWIESEEKRISVLMGLYQWMNEGKMGWRSCTLSMTPHYLFYVLSRFSELELTTGPMNIRLERLQNGNEGGNYVSFLKDYPNGWKKEDTSDTRSIRSVNSIRSVVKGVSNIWGRLSSGWRISPKERVYEQVRTDIMYLYSSFTKLPSLRLVPSSSYRMIDGYEEFPFDTAIPLFVFKNLKSLEIVNIEIGRFYGWDKIADNLRFLTVKGCGIRDASELIVDIVLKNIEKRRKMRIRKSNSLPLALRNKSVESNQIHPLIEMANISSIESSIDLKKAFVSHVRKFSSPLYDNSEVQYHPHNSDSSNRSCNSADTMPIAQPHPEILPLKKWYFLKYLSLSNNSLNMLSFSAVIPIARSLVSLDISHNMFIEIPYSLSILTSLKSLNISYNRIESLQSLMRHPLLSIATIDIRSNRLRSLIGIEKLINLQRLDIRDNCLSDPMEVTRLANAHTFKQIWVSGNPFTYKHFSTYRITIFNIFRSMPNHVCDVLIDGQGPGIMERRRLIEKVRKRKQISLESEKISHDSSNIDPQKIIFSEHGIVDFDEFPKDDQILIGKTIVKNNDCNIDNFSLVQNNDVDMNFQKDEDYSHQVEALKKNAGKNWLTVLNEEMWVKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7PFG8</accession>
    <name>M7PFG8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Small nuclear ribonucleoprotein Sm D2</fullName>
            <shortName evidence="12">Sm-D2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 12">snRNP core protein D2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_02540</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874553.1">
        <property type="nucleotide sequence ID" value="XM_007876362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PFG8"/>
    <dbReference type="STRING" id="1069680.M7PFG8"/>
    <dbReference type="GeneID" id="19896232"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02540"/>
    <dbReference type="eggNOG" id="KOG3459">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_2_1_1"/>
    <dbReference type="OMA" id="DVKEMWT"/>
    <dbReference type="OrthoDB" id="437526at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01720">
        <property type="entry name" value="Sm_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000018">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027248">
        <property type="entry name" value="Sm_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12777">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 14" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="30"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR09204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="114" mass="13103" checksum="10A3BFEE62D49A4D" modified="2013-05-29" version="1">MADLVSKPRSELTEAELQQLEAYEFDTGPLSVLQQAVRNHNQVLISCRNNHKLLARVKAFDRHSNMVLENVKEMWTETPRNAKGKKGKPVNKDRFISKMFLRGDSVILILRNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7PFS3</accession>
    <name>M7PFS3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sorting nexin-12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874239.1">
        <property type="nucleotide sequence ID" value="XM_007876048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PFS3"/>
    <dbReference type="STRING" id="1069680.M7PFS3"/>
    <dbReference type="GeneID" id="19895943"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02250"/>
    <dbReference type="eggNOG" id="KOG2101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AMYVVEV"/>
    <dbReference type="OrthoDB" id="120967at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="5">
        <location>
            <begin position="103"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="425"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="4">
        <location>
            <begin position="814"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1156" mass="133907" checksum="1E6E0A538E1D406A" modified="2013-05-29" version="1">MLSAEGISVRSTLVYIISSILIGRIFRFFSLYQIFILSVVYFILFIISVFYVAFKYLGRSMPNDYANVPGPLVFAKLSDWIKAIKAYEKEASLDKQCFPLHESLLISEELNKIIDLIIRDFVVKWYKEIAPQGVFPVIIEKNIRYSLIQLRNRVKTIDIEDIIVRRIIPIITAHIAECRAADLKVQNLGLKQNLTDLTELNLAVAKKYNNGKLHPAVTFSHSGSIMCQKDHLRKLVGQFIRFILPESEMNSKVVFSLIREIVSCGVLSPIIDLLTDPDILNQLIVTITSSIIQERKKIRRIRDVVKKHSLYEKMERQRYTPKFPLNNEKMFEKYIYFIKQCNNLSDLRKMRNDLILENHKFQSKIYSNKYNYENDQHIDHVLAKFQKSKYFIEKQIRILTGNINIDYSDFIMQTPEVLFAQKDIKLIEILHNVSGLSYFMEFMDQKNRIVLVQFWLVVNGLNNPSDHDISSKNDPLGVISTFPENLDVRLSYKEDISTIFETYFSENLLNISEENKNVIKEFIESSDIPEKYHNAKEALFKIQNEVFEIMREEDLPGFVKSEIFLKYLTTMAEETSKNFKDNFQNQILNNIANKTTILSESIPEHNSNPILNISSIQSSKKESSNSNEIDFDILQEVETALNNIIDNDDDDEQNKYEISSNIDCILDTSSERCSSYLKKTLTVPSDSGSNGFSYSANKKVRMPLFEEPEQFDIDTSFDNQNIDMDLTDADIHHASSGDLTLSEAIDNISMEINSLEAEESVLSSLIKKAELTNSISELRIFRKSIKTIQSELRRKRYQRQQYMIQENDNLLYGRSKISIPAVTIGLGMDGSQYTLYIIEIQKFDSSKVVTSGWILGRRYSEFFHLHQRLKMYFPKVRNIDLPKKSVVLKMQKSFVEGRRIMLEKYLQTLLQIPEVCSSKELRIFLSQQNSTLPSLQKNSDLISYSDPREIVGYIFKYLSEDMEDTSPNSAFIDNFPETNLNILNTITSKENIESSVTRQPQNLKGLENDVTAFTKPICDLFLEVFDLRKSNNWLKGRAIIIILQQLLGGTIERKVRETLRNAFGEQSILNILQALKDTLWPNGILIKNRPLRSYEEKTKTRVEASFLFSAIFPVYLPDIAPKKIFNMLQNPLLNSHLIFNIFDEIVEIIFPEIRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7PG21</accession>
    <name>M7PG21_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calcium-binding protein 39</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mo25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874358.1">
        <property type="nucleotide sequence ID" value="XM_007876167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PG21"/>
    <dbReference type="STRING" id="1069680.M7PG21"/>
    <dbReference type="GeneID" id="19896047"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02354"/>
    <dbReference type="eggNOG" id="KOG1566">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035755_0_0_1"/>
    <dbReference type="OMA" id="AYDHKES"/>
    <dbReference type="OrthoDB" id="609103at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005933">
        <property type="term" value="C:cellular bud"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071958">
        <property type="term" value="C:new mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035839">
        <property type="term" value="C:non-growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007118">
        <property type="term" value="P:budding cell apical bud growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071574">
        <property type="term" value="P:protein localization to medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000100">
        <property type="term" value="P:regulation of establishment or maintenance of bipolar cell polarity regulating cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000920">
        <property type="term" value="P:septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000257">
        <property type="entry name" value="Conidiophore development protein hymA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013878">
        <property type="entry name" value="Mo25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182:SF3">
        <property type="entry name" value="PROTEIN MO25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08569">
        <property type="entry name" value="Mo25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="39010" checksum="002817134E7D080D" modified="2013-05-29" version="1">MAFFFNRRQKSVQDVVRGVKDGIQRLETLGSMADKKRVQEEVSRSLQAMKVLLYGDNDTDPVPDQVTQLSQQVYQTDLLYLFVVNFVHLEFESRKDVTSIFNVFLRRQIGTRYPTVDYLATKEDTLFILVRGYQIPEIALHSGLILRECFKHELLAKIVLWNSVFWEFFTYVESGTFDIASDAFQTFKELLIRHKNISADFLQNNYDDFFEKFTNLLNSSNYVTKRQSIKLLGEILLGRSNFNIMTTYIQSSENLKLIMNLLRDKSRNIQFEAFHVFKVFVANPNKTKQVLNILIKNKNKLLIFLSNFHNDRKDDEQFNDEKTFLINQIEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7PG60</accession>
    <name>M7PG60_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874397.1">
        <property type="nucleotide sequence ID" value="XM_007876206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PG60"/>
    <dbReference type="STRING" id="1069680.M7PG60"/>
    <dbReference type="GeneID" id="19896084"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02391"/>
    <dbReference type="eggNOG" id="ENOG502RWZH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1886617_0_0_1"/>
    <dbReference type="OrthoDB" id="3556830at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020999">
        <property type="entry name" value="Chitin_synth_reg_RCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28187">
        <property type="entry name" value="PROTEIN RCR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28187:SF1">
        <property type="entry name" value="PROTEIN RCR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12273">
        <property type="entry name" value="RCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="135" mass="15796" checksum="B65B2F1047E0BB2D" modified="2013-05-29" version="1">MDTTQRLWKRHYCDYKPTLQERYDCYSRWNAWGRWIVISIILIGIILLFTCLFCANKWRAEQGNAPIKYTGWFMPWQAYPPTQPYGYAMPMTSSYQHPGGPGRPWQNEQHPVPPYEPPNASSSNAQPPSPSQKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7PH63</accession>
    <name>M7PH63_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab GDP dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873935.1">
        <property type="nucleotide sequence ID" value="XM_007875744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PH63"/>
    <dbReference type="STRING" id="1069680.M7PH63"/>
    <dbReference type="GeneID" id="19895652"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01958"/>
    <dbReference type="eggNOG" id="KOG1439">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021695_0_0_1"/>
    <dbReference type="OMA" id="FETKAKM"/>
    <dbReference type="OrthoDB" id="9446342at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005093">
        <property type="term" value="F:Rab GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.10:FF:000001">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000806">
        <property type="entry name" value="RabGDI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF8">
        <property type="entry name" value="RAB GDP DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00892">
        <property type="entry name" value="RABGDI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="437" mass="49755" checksum="D0B04874B25B9599" modified="2013-05-29" version="1">MNETYDYIILGTGLKECILSGLLSVENKKVLHLDKNNYYGGETASLSLNQIYKKFYPGQEPPSYLGNDRSWSIDLIPKFIIANGELTRMLYHTDVTRYLEFKSISGSFVYKDKKIAKVPATDIEAIRSPLMNLFEKRRMKKFLEFICNYDENDTTTHQSLDFNHDSMDKVYSKFNLETGTKEFIGHAMALYLDDSYLFQPAQETYKRIILYINSVALYGKSPYIYPLFGQGDLPQSFARLSAVYGGTYMLNRKVDEIVYENGVAIGIKSDGEIAYASKIIGDPSYFPDRVRKTGKVIRVICILNHPIPNTDNSDSLQIIIPQSQVRRKHDIYIAMVSSVHNVCPKGYYLAIVSTIVETDNPHIEVEPGLNLLGPIVKKFIYVSDILEPIGDSKDNIFVSKSYDATSHFETATEDVNRIYRQAEGRDLIVKRSITTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7PH88</accession>
    <name>M7PH88_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01985</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873965.1">
        <property type="nucleotide sequence ID" value="XM_007875774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PH88"/>
    <dbReference type="STRING" id="1069680.M7PH88"/>
    <dbReference type="GeneID" id="19895679"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01985"/>
    <dbReference type="eggNOG" id="KOG3379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_7_1_1"/>
    <dbReference type="OMA" id="DAIYGMM"/>
    <dbReference type="OrthoDB" id="680339at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004081">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015964">
        <property type="term" value="P:diadenosine triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000011">
        <property type="entry name" value="Fragile histidine triad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051884">
        <property type="entry name" value="Bis(5'-adenosyl)-TPase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243:SF1">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="8">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="4 7">
        <location>
            <begin position="95"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="3">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="90"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for induction of apoptosis" evidence="6">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="169" mass="19454" checksum="1DD8FAE5E5AEF7D7" modified="2013-05-29" version="1">MISEIYFGPFLVSKQVFFHAKNSLALVNLKPVLPGHVLVIPRRPVPRLRDLTESEILCLFSTVQKVSSVVEKAFCASSCTVTIQDGKYAGQTVPHLHVHIIPRKPYDLKENDEIYERLASEDADLGKLYREKTKGFQKIDDADRKPRSDKEMEEEARWLEEFFDFNNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7PHB6</accession>
    <name>M7PHB6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Geranylgeranyl transferase type-2 subunit alpha</fullName>
            <ecNumber evidence="6">2.5.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Geranylgeranyl transferase type II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="6"/>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874000.1">
        <property type="nucleotide sequence ID" value="XM_007875809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PHB6"/>
    <dbReference type="STRING" id="1069680.M7PHB6"/>
    <dbReference type="GeneID" id="19895714"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02020"/>
    <dbReference type="eggNOG" id="KOG0529">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031996_0_0_1"/>
    <dbReference type="OMA" id="RKFPKCY"/>
    <dbReference type="OrthoDB" id="1658at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF2">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="324" mass="39242" checksum="1BD6512692CBD218" modified="2013-05-29" version="1">MNKNTSKKKTHKEIESLLKDIQKHFKNNNYNYEILTLTTEFLKESYENYTIWNYRRDILKNGVLLHTEYDKTIIQNIISKELQFLNELIKKYPKIYNIWSHRKWCFENAPFPIWEQEKAFLDLILTKDSKNFHAWNYRQYIIPMLEKQNKTSYVKNELDYTTSVLKDNFSNFSAFHYRTTLIPRFINESSYDYLERKHFFDQELFLTKSIIYTSPDNCSIWTYHNWLLNSISKLNDSLLSDDVTVKLNYINQEIKMIEDLMELEPNRKYLMNAYINYNILLSKTSKNLLNIPKKKIIETATKLKEIDFLRKGRYDDLILSLEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7PI59</accession>
    <name>M7PI59_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01424</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873363.1">
        <property type="nucleotide sequence ID" value="XM_007875172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PI59"/>
    <dbReference type="STRING" id="1069680.M7PI59"/>
    <dbReference type="GeneID" id="19895121"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01424"/>
    <dbReference type="eggNOG" id="KOG1749">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115574_0_1_1"/>
    <dbReference type="OMA" id="KFRWSQR"/>
    <dbReference type="OrthoDB" id="1713912at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000007">
        <property type="entry name" value="40S ribosomal protein S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_uS12_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003254">
        <property type="entry name" value="PRK04211.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="143" mass="15970" checksum="B4FB42B2E277CD63" modified="2013-05-29" version="1">MGKPQGLNAARKLRTHRRKERWSDQLFKKRLLGTLYKSSPFQGSSHAKGIVLEKVGVEAKQPNSAIRKCVRCQLIKNGKKITAFVPNDGCLNFLDENDEVLIAGFGRKGKAKGDIPGVRFKIVKVSGVSLLALWKEKKEKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7PIZ7</accession>
    <name>M7PIZ7_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_01140</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LOC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873054.1">
        <property type="nucleotide sequence ID" value="XM_007874863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PIZ7"/>
    <dbReference type="GeneID" id="19894837"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01140"/>
    <dbReference type="HOGENOM" id="CLU_2085791_0_0_1"/>
    <dbReference type="OrthoDB" id="1743802at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037650">
        <property type="entry name" value="Loc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28028">
        <property type="entry name" value="60S RIBOSOMAL SUBUNIT ASSEMBLY/EXPORT PROTEIN LOC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28028:SF1">
        <property type="entry name" value="60S RIBOSOMAL SUBUNIT ASSEMBLY_EXPORT PROTEIN LOC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="87"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR10424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="117" mass="13867" checksum="2CDAC25515066142" modified="2013-05-29" version="1">MSVFRPKNTISDDPKQFSEKKMPISLLNTSTPAKIQKPKKIFVEDKATLLSILEEVNRRLDNRAKIKQEKRKELEAIRCIKKSKIEMRKQAKKNKKQEKWENTLSKIRNKKYSISHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJB4</accession>
    <name>M7PJB4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase II subunit 2</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">ATP-dependent DNA helicase II subunit Ku80</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PNEG_01255</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ku80 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873178.1">
        <property type="nucleotide sequence ID" value="XM_007874987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJB4"/>
    <dbReference type="STRING" id="1069680.M7PJB4"/>
    <dbReference type="GeneID" id="19894952"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01255"/>
    <dbReference type="eggNOG" id="KOG2326">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010975_1_1_1"/>
    <dbReference type="OMA" id="WAMQYVW"/>
    <dbReference type="OrthoDB" id="30826at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00873">
        <property type="entry name" value="KU80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000073">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024193">
        <property type="entry name" value="Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF4">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="VWFA" evidence="18">
        <location>
            <begin position="6"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMR10549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="563" mass="63959" checksum="2739F05450D9E6E1" modified="2013-05-29" version="1">MSEKEVTVFVIDLDKRMKNCENNRTQSNLEWVLSYFWNKISSKVLSGRKTDCVGVVGFKTDETNNDMEDDKFYENISVLCPIQQITIKEIKELKKQLIPSNTDVGDAISAVIIGIDLISKYCRNLKYIKNLILITNGESDMNFSDLEKIAYQIRYMSINFSIFGIDFDTNGYKEVAKNTIKLNNEKNLLKFSNISNGTFSSMVEAIDSLNIPSVKKIRPISLFGGILSIGYSQNYSNVIEIMVQRYPRTRLAKMPAAHRYNVSGIIPKSTDYNKESTKTSTNLSDDDKNECFNEILTTKSYKIEEDGDEKEISKEDLELGYIYGKTIVPVNIIDEEEMVYKEDTGLTILGFIKNKSFPRFIALGEANIIVPAKANLNAKISLSSLVHAMLKTNTLALARIVTKANKFPEMIIMAPSIENNFECLIELTLPFLEDCKNFKFPSIKKDNILSNKKGSSMKDIDTLMEKYVTKMDLSNKTQDNNIKKTSQLKSMCIYNIALYRLNQAISSAAIYPDLELKNLLPDIKQFMYPSDDLLKRCEEEIKTLSELCNIKETILTVPESTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJS3</accession>
    <name>M7PJS3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00855</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872764.1">
        <property type="nucleotide sequence ID" value="XM_007874573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJS3"/>
    <dbReference type="STRING" id="1069680.M7PJS3"/>
    <dbReference type="GeneID" id="19894553"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00855"/>
    <dbReference type="eggNOG" id="KOG3991">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014832_3_0_1"/>
    <dbReference type="OMA" id="ADHVQIT"/>
    <dbReference type="OrthoDB" id="18915at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22749">
        <property type="entry name" value="Otubain_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.60">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.20">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019400">
        <property type="entry name" value="Peptidase_C65_otubain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042468">
        <property type="entry name" value="Peptidase_C65_otubain_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042467">
        <property type="entry name" value="Peptidase_C65_otubain_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931:SF15">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTUBAIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931">
        <property type="entry name" value="UBIQUITIN THIOLESTERASE PROTEIN OTUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10275">
        <property type="entry name" value="Peptidase_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="7">
        <location>
            <begin position="40"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="243" mass="28379" checksum="6BD77DE2F7313501" modified="2013-05-29" version="1">MNVETNIDPLVHDCIPIQELLKEYQENETFYKKIKALGNMSLYRIKRDGDCFYRALCFGWLWTLMHQTPRDSEKNIIEFSRTTELLQKSGFELLSYEDLYEEALLALSLLKPDENQDNQAKEKELLTLMNIPEKSNAIVVYFRFLTSAYIKQNAHKYAPFLDVPSVADVFAFCQNTIECIGKEADHVMINALSKALQVCIHIYYIDRSDSDQAKKYEFTVENENPITICLLYRPGHYDFIIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M7PKD0</accession>
    <name>M7PKD0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872968.1">
        <property type="nucleotide sequence ID" value="XM_007874777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PKD0"/>
    <dbReference type="STRING" id="1069680.M7PKD0"/>
    <dbReference type="GeneID" id="19894753"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01055"/>
    <dbReference type="eggNOG" id="ENOG502SECK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1294890_0_0_1"/>
    <dbReference type="OMA" id="AQETIMN"/>
    <dbReference type="OrthoDB" id="4093188at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013175">
        <property type="entry name" value="INO80_su_Ies4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28061">
        <property type="entry name" value="INO EIGHTY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28061:SF1">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08193">
        <property type="entry name" value="INO80_Ies4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="213" mass="23189" checksum="F469F0E9F56C7DCC" modified="2013-05-29" version="1">METKIISPPLSSVLYSKNIPLPAQETIMNNVQEHYTSQTPIKSNNSKYQSRIVKLKVNISRLASQSEPVGTPMSSPLPMSSPVLASSPVSNIINNGNIIKKTGKKARLSNNTGPKTIRRRKAEAATVIVINVEDASQKQGQQNIVINGQKTGSTPLSHSRLGPKANTGAINAGLRALDRSGKPCKRWYKRMITIDCINGIQWETNGWKDTSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M7PL13</accession>
    <name>M7PL13_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872656.1">
        <property type="nucleotide sequence ID" value="XM_007874465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PL13"/>
    <dbReference type="GeneID" id="19894453"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00755"/>
    <dbReference type="HOGENOM" id="CLU_096893_0_0_1"/>
    <dbReference type="OrthoDB" id="5391397at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="135"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="251" mass="30114" checksum="5CF2019EF922E934" modified="2013-05-29" version="1">MNIFLNLIQKITHFGATEDDRSFLEEMSIWEQKLKNLPHTKHLIKTIRLSLEKVLEIEEINEKLNTLNMIKKRLFSEICIIKKFLSEINQLYEVQEDIERSFSKAETLWKQLKDLDNIVSQKLKEKNLYDYKKWKSKAQNDLEEYKKMRLNKLEKKKLDYDEQLRKFAQERKMLYENIKSIPSSSKEKASINLEEELKNIELPLILNELESFFGEIKEPDITNLTIFEKDDHKKHNPTIDIIEDEDFNSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7PLU4</accession>
    <name>M7PLU4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">UvrD-like helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_00454</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872335.1">
        <property type="nucleotide sequence ID" value="XM_007874144.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7PLU4"/>
    <dbReference type="GeneID" id="19894152"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00454"/>
    <dbReference type="eggNOG" id="KOG1801">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000459_2_0_1"/>
    <dbReference type="OMA" id="MIFMECW"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001147">
        <property type="term" value="F:transcription termination site sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18042">
        <property type="entry name" value="DEXXQc_SETX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024481">
        <property type="entry name" value="Helicase_Sen1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056474">
        <property type="entry name" value="SEN1_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23576">
        <property type="entry name" value="SEN1_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12726">
        <property type="entry name" value="SEN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase Sen1 N-terminal" evidence="7">
        <location>
            <begin position="3"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase SEN1 beta-barrel" evidence="10">
        <location>
            <begin position="1035"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="8">
        <location>
            <begin position="1183"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="9">
        <location>
            <begin position="1472"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1338"/>
            <end position="1370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR11434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1804" mass="208386" checksum="9A610E1BDEA7FE85" modified="2013-05-29" version="1">MSIHKYIEHLREFDYERIYETLSELSNEILLEKNEITMNFRKFLVIYECMWDVELLEKEELKNKFKDIFLAIQKKNKFLRIYDEVVPAMVYFLFDEKFQDFYSWAEISLKKLSRKLNLFEFTSIAKKPFTIAMDNYLKTNNAMFKTSMSIFWKGVSILFHYTEKESIIADLYSQGWDIVGLTCSRFSENTPIILDILNAFFTLLDVLGSTFWEQAMYCNPLNAIDTICQNNYIHKLIKTLDMSNSQMNESSYMSFVLPFIWVKPFINSLQDSNRHHSCSRFMLYFLEYFQQDDYSKENRDNCKILAYQILSMEFEILLKSGFMDFDAYLILIQENKKVFEKYLGIVEESLFSTQTNDFLKSEACRLIGFVLKVDCKILQQEFSNMMKKSEKFDDSVMTITNYTLGRIWDILIQNIRDCDLDIMSQIFQSLSSLSCIEIIQESEKFVYFNKIAMELILKATQLFCKFDGMGSDIFKTMLQVPEINHSIISLLFSPVIEIGQLSSNIIKQAYDCIDQYEIFRFDLSHNFVSTLVGLINAVDNFENIQSFSVASKLIKAFVIVLDILCSSENGLLLLDQYKSKDYRPVIILLWSQFWTFLKMSFLFSLSWANDFPKDSMVVFIRDVLKMVSNMVIYSKVYDSIILLDNGDSEESFHTFHKLFFQIQDCLKYSFRWLRLSDKELLISTVDFICLLLFRLKVGNIVVEESVLAILRDFLEKKSYKTSLTNEQKIKLCSALQEFELMLDKFNDVKVYESSILSQKLLGNNSKICVGDVERKTSDISRSESLELGSLSNFASETKSKVQTKMVMEVLNSKAVLPSHESGNNLNKYNLKNLGYSKNKSLNSHRLGFKSSSIRQFRLDLLRDKKINRELRKSIKTSTNTLGSKLFRSEAHSDDLKDRDLEELVSSDTESGNSNIDNLPLMKGKISPKIRQIKRKSVQRLDHDIVGSSLFSKQKLQKQKVNTLKMKLFPSLSPLHKQVLQWNVSYNGEIPPCAIKQTYLEVDNKFQTPQAYLDTFEPLLLLECWQQIIKAKEENTDETFKIKIINRISVDEFIDLYVFISYEIFNSLVILDSDILVISDVSNPFTEFNAKSCLARVQTISKKKNSVELILRTCPLNKITALFYPSNELYGLKLFSLVTIQREYSALKSLEYLELCDSIINARSQPFPLVSSAEIQHAMTTYDVNEPQAEAIVGVTKSTGFYLIQGPPGTGKTKTILGMINAFLSQSKNRFCSGETHENNSISSRILVCAPSNAAVDEIVLRLKQGLPDSKGIKYYPKIVRVGSNTAVNFNVKDVTLDNLVEMELSKSNIKLEHGNQNVNQKTLREQLNEILKRRDFLFMQLENQVTEQEKKKMEIELKSLNFQKNNLGQQLDELRDPLNGTGKSLDIIRHDVQIDILKSANVICTTLSASGYELLGNLAFDFPTVIIDEAAQCIELSTIIPLKYGCRRCVLVGDPNQLPPTVFSQVAANYLYEQSLFVRMQKNCPSSVHMLSIQYRMHPCISQFPSKIFYSNKLFDGENMREKAKRPWHQINLFGPYRFFDIHGYEDEVSCSPFNLMEARAALLIYEAITQKFPSVNFNGSFGIITPYKQQLSKIKELFIKKYGNLIFENVDFNTVDGFQGQEKDIIILSCVRTSTKGIGFLSDIRRMNVSLTRARSSLIILGNVKALSCHSYWYSLIKDSKERGLLTKFDDIFKILKEKKDADFCNFDIKSDEKVNYKVDSFGENTGIQNFRLELIENTSCLKNNNNIISENFQVSEERVDKKAGSDSNFLIPSEKKPDVSLLIHKRRLDCDIFIRRPKIKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7PMK4</accession>
    <name>M7PMK4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Golgi apparatus membrane protein TVP23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00133</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Golgi membrane protein involved in vesicular trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Golgi apparatus membrane</location>
            <topology evidence="2 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TVP23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871994.1">
        <property type="nucleotide sequence ID" value="XM_007873803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PMK4"/>
    <dbReference type="STRING" id="1069680.M7PMK4"/>
    <dbReference type="GeneID" id="19893831"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00133"/>
    <dbReference type="eggNOG" id="KOG3195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074845_2_1_1"/>
    <dbReference type="OMA" id="KMIWWID"/>
    <dbReference type="OrthoDB" id="2151161at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008564">
        <property type="entry name" value="TVP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019:SF7">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05832">
        <property type="entry name" value="DUF846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="181" mass="21227" checksum="842C30A429712555" modified="2013-05-29" version="1">MIDRGVHELHLNNNLSIGQNKDSSIFELSSHPIALFFFFFFRFLAILLYLFGFFIFRNFILVFILIVIFSAFDFWTVKNVSGRLLVGLRWRNEIDDEGKNIWVFENANLQNKQNPTDSKIFWLVLYLTPIIWGIFGIIAILRFNFIWLVTVIIAFSLSGTNALAFTKNEIILFFIFLLIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7PN04</accession>
    <name>M7PN04_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="3 12">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_00262</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="3 12"/>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872134.1">
        <property type="nucleotide sequence ID" value="XM_007873943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PN04"/>
    <dbReference type="STRING" id="1069680.M7PN04"/>
    <dbReference type="GeneID" id="19893960"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00262"/>
    <dbReference type="eggNOG" id="KOG2144">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035267_0_1_1"/>
    <dbReference type="OMA" id="AWINDKG"/>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000040">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006330">
        <property type="entry name" value="PRK08560.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR11839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="361" mass="41263" checksum="7EBF8C714A15795F" modified="2013-05-29" version="1">MTFTNELVNKKYNLITRGLQEVLGAERLKKILEERDLKLYWGTSPTGKPHCGYFVPMIKIADFLKADVEVTILFADIHAFLDNLKAPIDIVKYRAKYYEYIIKAILKSIGVSTEKLRFVLGSSYQLTSKYSMDNFRLCTIVTEHDAKKAGAEVVKQVENSLLSGLLYPVMQALDEEHLDSDAQFGGVDQRKIFTFAEKYLPMLGYKKRIHLMSPMIPGLSGGKMSASGNENNKIDILDDAETVKKKINKALCVEATVENNSLLEFAKHVIFPVLALKGIPTLMINREEKWGGQVLYNSYELLELDYVNRRLSPQDLKIGISDSLNFILESIRLEFMENEEFQQILHFAYPDQEKQKSKKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWZ3</accession>
    <name>A0A0W4ZWZ3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_04289</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="KTW32902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613374.1">
        <property type="nucleotide sequence ID" value="XM_019757808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWZ3"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZWZ3"/>
    <dbReference type="GeneID" id="30671578"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04289"/>
    <dbReference type="eggNOG" id="KOG0686">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2707">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RGIDEQW"/>
    <dbReference type="OrthoDB" id="422427at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="207"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KTW32902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="426" mass="50589" checksum="0BACF661AD139D29" modified="2016-03-16" version="1">MVDETLDISLPTFDLNSYINNYKGYTRIERLIFISEHCSFLCVEALKLAIELSQTETLDTVLYEKLVTRLQQKDSSECNIVLDTEWIHETKKNTKNILQKLKSRLKNYKNNFIKESIRMGYKDLANYYYLCRDLENSLKFYFKVHEYCATSKHSMDTLLNMIKIFLELKDFINANTYLIKIQNMSCKNEITSKIEVISGLIYLNLENYKEAALKFCMIKMEEDMEFNDIISVNDLVIYAVICALSSFSRPELKQYIIDNVEFWKLHELEPQVFEIVTAFYSSNYLKCFDILNRLKNDFMLDIYLNRHVDNLFLYIRQRAYILYLKPFSYVDLRKMANVFLFLLNNMEKELIQLILESKISAKIDNINKFLIIIEPSQQDMIYEKILKISNEYKRAAKLSLIHMELVKKGLEIKTMCDLNIDIENEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZX00</accession>
    <name>A0A0W4ZX00_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Protein farnesyltransferase subunit beta</fullName>
            <shortName evidence="9">FTase-beta</shortName>
            <ecNumber evidence="2 9">2.5.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_04300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11535"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:86019"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="2 9"/>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="KTW32896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613369.1">
        <property type="nucleotide sequence ID" value="XM_019757818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZX00"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZX00"/>
    <dbReference type="GeneID" id="30671585"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04300"/>
    <dbReference type="OMA" id="MLYWIAN"/>
    <dbReference type="OrthoDB" id="10261146at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02893">
        <property type="entry name" value="FTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026872">
        <property type="entry name" value="FTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF6">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="10">
        <location>
            <begin position="37"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KTW32896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="401" mass="45073" checksum="1602D7F1B4E30BC3" modified="2016-03-16" version="1">MHPLILPDTIQTETSVLQDQTEQICLPYLTDKVNSQLNQKTHIEYLLNILTKPLPKSYLALDASRPWIIYWTLCAYALLGQSVEEYRERTIQSISVLQLESGGFSGGHGQIAHLAPTYAAVMALCIVGSEAAYNIINRSSLYCWIMRLKQSDGSFLIHEGGEKDARAVYCALSVASLLNLMTPELIEGTAVWLSRCQTYEGGLSGFPGAEAHGGYAFCVLASLTMIGKPSMIFDQYLNISKLMRWLALRQSSVEGGFSGRTNKLVDGCYSWWIGGCWAILSSVIEDVRTPLVDKNALRRFILTCCQYKTGGLRDKPEKYPDQYHTCYCISGLSVIQNVYFYSENDKKDTALGESVFNWYHDHLIEQSVFATDQIKAVHPILAIPMDKLCDIWLWRIKKDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZX05</accession>
    <name>A0A0W4ZX05_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial 2-oxodicarboxylate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_04301</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="KTW32897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613370.1">
        <property type="nucleotide sequence ID" value="XM_019757819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZX05"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZX05"/>
    <dbReference type="GeneID" id="19895434"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04301"/>
    <dbReference type="eggNOG" id="KOG0754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LPFQYQF"/>
    <dbReference type="OrthoDB" id="434783at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051752">
        <property type="entry name" value="Mito_2-oxodicarb_carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356:SF1">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="6"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="102"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="197"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KTW32897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="33001" checksum="0332D14DA7DE10BD" modified="2016-03-16" version="1">MTTSTVPFSVTFVAGAVAGISEIFLMYPLDVVKTRFQLNVGKAEYQGMKDCLISILKKEGVFRLYRGILPPILMEAPKRATKFAANEHWGLFYRNFFGMEKMNQGLSLITGATAGATESFIVVPFELIKIRLQSKANASKYKGAFDCLIKVSRDEGLFALYNGLEATMFRHITWNAGYFSVIFSVREKLNKLEWKMDERFKNFLAGTLGGISGTLLNTPFDVVKSRIQNTPKLSGQKPKYNWAIPSLWTIYKEEGFFALYKGFLPKVVRLGPGGGILLLVFDQVSKKNITLHSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NHK0</accession>
    <name>M7NHK0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein GZF3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_03485</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875575.1">
        <property type="nucleotide sequence ID" value="XM_007877384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NHK0"/>
    <dbReference type="STRING" id="1069680.M7NHK0"/>
    <dbReference type="GeneID" id="19897172"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03485"/>
    <dbReference type="eggNOG" id="KOG1601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035349_2_1_1"/>
    <dbReference type="OMA" id="QNCATSI"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056998">
        <property type="entry name" value="Asd-4/GZF3_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25026">
        <property type="entry name" value="Asd-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="9">
        <location>
            <begin position="39"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="83"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="158"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="282" mass="31631" checksum="B7AF6FD313787C4A" modified="2013-05-29" version="1">MLMKQRSNSDGISDENNISTRYLSRSNSAPLQISGSPVCQNCATSITPLWRRDESGATLCNACGLFLKLHGCSRPTSLKTDIIKSRNRIKNTKTRSVESSETMGRTTRSGTASPPEEENRCAASNSGVGHQPSAVAGHSETFYDGAAARNVGETVPTIDSLLQANAALRTRVSELELVNDLFRSRVSELEMNEAQMRRQDANLNDLDRQLRLREAELQRREAYLHILMRDMHHDLEQEEQQKRKKIRVSELLEETESFLINALPLESETKKIKIEHPILSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7NHW1</accession>
    <name>M7NHW1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">UBZ4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_03590</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875684.1">
        <property type="nucleotide sequence ID" value="XM_007877493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NHW1"/>
    <dbReference type="STRING" id="1069680.M7NHW1"/>
    <dbReference type="GeneID" id="19897277"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03590"/>
    <dbReference type="eggNOG" id="KOG2028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017985_0_1_1"/>
    <dbReference type="OMA" id="RIILSQC"/>
    <dbReference type="OrthoDB" id="10265467at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18139">
        <property type="entry name" value="HLD_clamp_RarA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000001">
        <property type="entry name" value="Putative AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000137">
        <property type="entry name" value="Replication-associated recombination protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3710.10">
        <property type="entry name" value="DNA polymerase III clamp loader subunits, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051314">
        <property type="entry name" value="AAA_ATPase_RarA/MGS1/WRNIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779:SF7">
        <property type="entry name" value="ATPASE WRNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779">
        <property type="entry name" value="WERNER HELICASE-INTERACTING PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBZ4-type" evidence="11">
        <location>
            <begin position="5"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="141"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR08153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="58936" checksum="9245B038D79DC78F" modified="2013-05-29" version="1">MTKKYVLCPICGKDVNIDLINTHLDRGCDSHEKKYSLSLGSIQQKLFNENFLNKSFPCNKNHRYSENILSCPSLSKRGVQNENELSSKEASYLKKSKNNSNFEFYSPLSERVRPQTLDDFVGQEDLIGKYGLLRKLIENDKFPSFILWGASGVGKTTLARIISKTTNNQFKEFSATSSTICDVKRAFDDAKKMLSLTGRKTIIFIDEIQQFNKMQQNVFLHYIEEGIVILIGATTENPSFKINNALLSRCRVFVLHKLSSMHVFEILKNAISIIKSSSENIINIDDSVIEYLANLSDGDARIALNTLEIILNFETKENDIITKESVRNILKRTSFVYDRVGDSHYDTISAFHKSIRGSDANAALYYLGRMLLGGEDPLYIARRMIRIASEDIGTSDNNALILAISAYQAVQSVGMPEADIFLAHAAIYLAEAKKSNRIYLALNNVKHVLKTEDGAFSAEIPLHIRNCPTKLMSELGYGVGYKYNHLYKDGKVKQEYLPSTLKTRIFLDVDKEMILDPEFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NHW5</accession>
    <name>M7NHW5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Nuclear transport factor 2</fullName>
            <shortName evidence="3">NTF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_03333</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875411.1">
        <property type="nucleotide sequence ID" value="XM_007877220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NHW5"/>
    <dbReference type="STRING" id="1069680.M7NHW5"/>
    <dbReference type="GeneID" id="19897020"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03333"/>
    <dbReference type="eggNOG" id="KOG2104">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131642_0_0_1"/>
    <dbReference type="OMA" id="QFVEYYY"/>
    <dbReference type="OrthoDB" id="6507044at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000005">
        <property type="entry name" value="Nuclear transport factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="4">
        <location>
            <begin position="7"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU369002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="124" mass="14325" checksum="7829836578EC28AF" modified="2013-05-29" version="1">MTDINQLAAQFTDYYYKNFDTNRSQLASLYRSNSMLTFENSQIQGVEKIIQKLMELPFEKVLHKITTIDAQPSMLSGGSIIVMVTGQLLVDEEQNPQQYSQTFHLIPEGNTFYVLNDIFRLNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M7NI06</accession>
    <name>M7NI06_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA 2'-O-methyltransferase fibrillarin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Histone-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_03364</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
            <dbReference type="Rhea" id="RHEA-COMP:12837"/>
            <dbReference type="Rhea" id="RHEA-COMP:12839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875446.1">
        <property type="nucleotide sequence ID" value="XM_007877255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NI06"/>
    <dbReference type="STRING" id="1069680.M7NI06"/>
    <dbReference type="GeneID" id="19897051"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03364"/>
    <dbReference type="eggNOG" id="KOG1596">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059055_1_0_1"/>
    <dbReference type="OMA" id="WNPNKSK"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140517">
        <property type="term" value="F:protein-RNA adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000056">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000001">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020813">
        <property type="entry name" value="Fibrillarin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00566">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR08193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="281" mass="31325" checksum="47A57652F741B53D" modified="2013-05-29" version="1">MGPKAGHGQKGQKGRYDKSQKQRRGDSRGMKSRGAPIRNKRFNRPRATKVIIEPHRHPGVFVARGKEDFLVTKNLVPGESVYGEKRISVEADGKKTEYRVWNPFRSKLAAGILGGLDEIYIRPGSKVLYLGAASGTSVSHVADVVGPEGLVYAVEFSHRSGRDLLHMAQKRTNVIPIIEDARHPQKYRMLVGMVDTVFADVAQPDQARIIALNAHTFLKNSGGIVISIKANCIDSTVEAATVFAREVKKLQEERIKPQEQLTLEPYERDHCIVVGKYIRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NI28</accession>
    <name>M7NI28_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic peptide chain release factor GTP-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ERF-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">ERF2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Polypeptide release factor 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Translation release factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_03382</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875466.1">
        <property type="nucleotide sequence ID" value="XM_007877275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NI28"/>
    <dbReference type="STRING" id="1069680.M7NI28"/>
    <dbReference type="GeneID" id="19897069"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03382"/>
    <dbReference type="eggNOG" id="KOG0459">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_3_8_1"/>
    <dbReference type="OMA" id="ARFDECT"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03704">
        <property type="entry name" value="eRF3_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04089">
        <property type="entry name" value="eRF3_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000503">
        <property type="entry name" value="Peptide chain release factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003285">
        <property type="entry name" value="Sup35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01343">
        <property type="entry name" value="YEASTERF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Tr-type G" evidence="14">
        <location>
            <begin position="201"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR08213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="630" mass="71655" checksum="FCEA1A2FD2AA5E3D" modified="2013-05-29" version="1">MSSEAKNVDVDDTWEERIDQEEILEKIGKLRMSAEAEEFRPRNLYYEPQDFSANYDINNVPYGYFNMSYDQNYDRRKYHPYNNDYSARDRDIRLCEKVLAPPEVKVSTLGGQRTTSKVIKIGECSKTPFSEESVVGRNGNKINKVDKGFCSVDMENLSLGASKQEKNHVSVGGDEERRDYDIVSQFQEEIDEEVLQDMYGKEHLNVVFIGHVDAGKSTLGGNILYITEMVDKRTMEKYEKDAKEAGRESWYLSWALDSTKEERSKGKTVELGRAYFETEKRRYTILDAPGHKSYVPNMIEGTAQADVAVLVISARKGEYETGFEKGGQTREHAMLSKTQGVSKLVVVINKMDDPTVEWSKERYDECTNGISMFLRKEVGYNPKTDFVFMPISAFTGVNIKERIDKKICPWYNGPSLLEYLDEMDTFERKVNAPLIIPIHAKYKDMGLVIEGKVESGYVKKGSNVILMPNKTVVEVIALYDELEEIRIGRCGEQVKLRIRGVEEEDVMTGHILSSLNSPVSTAKIFEAQIAILEVKNLLTAGYSCIIHIHSAVQEVTFLKLLYKLDKLTNRRSKKPPAFAIKGMKIVALLEAASPLCLETFDKYRQLGRFILRNEGLTVAIGKVTKLISEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NIJ8</accession>
    <name>M7NIJ8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_03244</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875311.1">
        <property type="nucleotide sequence ID" value="XM_007877120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NIJ8"/>
    <dbReference type="STRING" id="1069680.M7NIJ8"/>
    <dbReference type="GeneID" id="19896931"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03244"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_787825_0_0_1"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF32">
        <property type="entry name" value="ZINC FINGER PROTEIN RST2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="352" mass="39955" checksum="72BC84B032141ECC" modified="2013-05-29" version="1">MSNTDIERNHKKKVKNNKTFQCSGFGNCHMQFSRSEHLARHIRKHTGERPFKCYCGRTFSRLDNLRQHAQTIHTNEVINSPYSLSSNSLHTLTYKTRQSAAKNDSKQSEMATYKQNVETLEKNQETYTAKPKSNSIHLPVEKMMKSEDEDAFELSKFQSFIPNGFHSSDQIPDHYYSLKSFSPSLFFHSPIYNSLSSKTDPIPSKFSTLDLNLGLKTILPSNTNSPLPNECQNIQPLSQEIHPKNDFLKKNSSCNNSASITLYNNSCTLTSSNTPSPSDTTNSLRFNDNKLPSITILMDYDLQRSNIISLSNTNEHSLKHNNTQKMSIQFLCNQNITMGGIDILAEVAKIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NIY5</accession>
    <name>M7NIY5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_03045</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875100.1">
        <property type="nucleotide sequence ID" value="XM_007876909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NIY5"/>
    <dbReference type="STRING" id="1069680.M7NIY5"/>
    <dbReference type="GeneID" id="19896732"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03045"/>
    <dbReference type="eggNOG" id="KOG3282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073661_2_3_1"/>
    <dbReference type="OMA" id="CRQTLNN"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000001">
        <property type="entry name" value="Peptidyl-tRNA hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003314">
        <property type="entry name" value="PRK04322.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="128" mass="14320" checksum="74F80A6CE67849B7" modified="2013-05-29" version="1">MPYLNISEEYNEEYKLVLVVRTDLKMGKGKVASQCSHAAISCYKKLMCQNPKIIKYWELYGQPKIVLQVETKAELEKLHAHANSLGIISCIIHDAGRTQVEPNSVTVIGIGPGPKSIIDQITGYLKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M7NK15</accession>
    <name>M7NK15_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_02744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874774.1">
        <property type="nucleotide sequence ID" value="XM_007876583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NK15"/>
    <dbReference type="GeneID" id="19896435"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02744"/>
    <dbReference type="HOGENOM" id="CLU_2559250_0_0_1"/>
    <dbReference type="OrthoDB" id="76862at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071986">
        <property type="term" value="C:Ragulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024135">
        <property type="entry name" value="LAMTOR5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16672">
        <property type="entry name" value="LAMTOR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="82" mass="9282" checksum="42D99779EF397FF3" modified="2013-05-29" version="1">MNFTVALKKIVEKENVEGVILVDDNGLCLGSYGKVNEEYANKCIKFVDLELQTKMFAAVMSKKQKVLLHRDLGITTVLFMTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLD0</accession>
    <name>M7NLD0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major surface glycoprotein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02416</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09473.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874421.2">
        <property type="nucleotide sequence ID" value="XM_007876230.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLD0"/>
    <dbReference type="STRING" id="1069680.M7NLD0"/>
    <dbReference type="GeneID" id="19896109"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02416"/>
    <dbReference type="eggNOG" id="KOG3544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010455_0_0_1"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021041">
        <property type="entry name" value="Maj_surf_glycoprot_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003330">
        <property type="entry name" value="MSG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02349">
        <property type="entry name" value="MSG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12373">
        <property type="entry name" value="Msg2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Major surface glycoprotein 2 C-terminal" evidence="3">
        <location>
            <begin position="962"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="806"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1049"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1127"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="88"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="806"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="855"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="899"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1049"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1135"/>
            <end position="1155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR09473.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1178" mass="131766" checksum="22F77507754A2278" modified="2016-03-16" version="2">MLILKELANLYLSSKIISGSIFHSPTYMPLRDKRWVEEVAQKEAAMAQPVKRQAAGQAAGNDEIKEEQVLGLIVKKEYEDNAKCKKKLEEYCAELKKIDGKLENVDAKVKGLCEDGKQGEKCKNLKDKVKKELDDFKTELEKTLNDITDENCRKCEEKCVLLEEADPSNLEEKCVKLRDRCYGQRRQEVTKEILLRALKEKVNDTNECKKRMKEICQGLSEYSDELVLICFNSDKTCKYLKNTHVDSCKPLETELEDKELVEKCQEYLEKCYFYGSSCKNTKCDKVKNKCKGKGIEYEGPKLDFSPVKEKPRFPEKIEVENLYKRLGAKGIIVGKPKYKTLQDLTLLLIKGRNGKDEGEKCKEALKDCESFKHLDYELEQLCEDKDKDNKCKELVEVEDRCTNLKLELYLKGLSTEFEESNESKYVSWEYVPKSVTKEDCRKFESECFHLEGVCTNEIGKACENVRVACYKKGQDRMLNRYFQEGLKGLIGDLELATENLEKCQKSVVGNYTKLKKDRRYFAKCHRPTKLCYELLDDVILQSEELEVVLNLRRDFPSKEDCVELKKKCEDLESDSYLNHEKCDTLNRRCEYLKVTEELKKRLLKRGDDALRTQGNCTAVLKKECEELSRRGKEDFSVSCALREETCSFMVEQTENECLFLKNNMDIGKIIEKIENGKRNETLVEELCTLFDPYCHQYIENCPDRLKKTNNAGRKGVCLELEEKCKPFFEKLKLENELTHKLKGSLSDETKCKETLGKHCTEWKKEGNQTLNSLCEDAKKEELCKKLVKKVKEKCPTLKNKLDNEKDELEKKKDEYEKAKQESEKFAKEAKLVLSRPEQDGQGGGSKAQDGSVPKPVGPPVQPPAPAQPTPGGVPAPTLAPPAQPTSGGAPLPVPPAAPAAPGAPSTPGTPAAPAGPAAPGTPSTPSTPPAGPAGPSGGTPGAPAGPPAPGGSTPSGTTNTSNVILVRRTFVSGEVSQPEKKAFVATARALELYLELKEKCKGLKGDCEFRKDCPKCETVCKEIDELCEGIEGLKVTPHHTVTSTATQTTTTTATTTTTTTTTTTTTTTTTTTATTTESVDGGKVTEECTLVQTTDTWVTSTSLHTSTLTSTSTVTSTVTLTSMRKCKPTRCTSDSSKETETQKEEEKEEEVKPNEGMKIRVPEMIKIMLLGVIVMGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLT5</accession>
    <name>M7NLT5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_03540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875632.1">
        <property type="nucleotide sequence ID" value="XM_007877441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLT5"/>
    <dbReference type="STRING" id="1069680.M7NLT5"/>
    <dbReference type="GeneID" id="19897227"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03540"/>
    <dbReference type="eggNOG" id="KOG1812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017097_0_0_1"/>
    <dbReference type="OMA" id="IQIEVFR"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20353">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16630">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047546">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047544">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF42">
        <property type="entry name" value="FINGER PROTEIN (ZIN), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26191">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="257"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="621" mass="72951" checksum="CD4F91C0725173B4" modified="2013-05-29" version="1">MQEISVPSRKYTSENVSLPLSKNYFELLQLESLFPDADPLYLAECLAYYDEDAVQRSTLKIIFHCYGQYPKKSSWMHYIREDDKKNAKLDILNQIFPNIDVECLRNELIRRDDTYLLKSIESLLNIDIESTGVSRLRIGKIEPWQRFRSYEYISSVRFQLISEFPDVPSSTINAVMVENNNDYYRSKTVLSRMQGERWWKSLVSFVRKKRSKLNYVICEELSREMLNLEKKRRDQIVMKDFEHAVQLNWQEYYDKGLLIECGCCFSEYAWETLAYCSEGHIVCKKCLEKTVQEGIYGQGNLRGQLRIKCIFSNIETVCAGFYSKDILKNSLPSDLLKAYEDSLKFRCIFDSSCENLVTCPFCGYAEFIDVWKIKFYWKIFIMVFMIGFIMQLAFFLSFVMFLSSLIVITSVYLSGFFFIINCSSNFLRKWIDKTAYRILRKRSCSLFKCRNVDYCGKFSCCRCRKEWMPFHKCFEKELDGLRLYVEREMANAVKRTCPVCNLSFVKSDGCNKLICQCGYVMCYICRKNIKKESYAHFCHHFRSIPGKKCTECTKCDLYKVDDNIAEVAERATKEYLLGCKDSGVWLGLKHHTELLKDGSLFGRILVVINNLLELFLEHILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLU4</accession>
    <name>M7NLU4_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ATP-dependent rRNA helicase rrp3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_03549</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875642.1">
        <property type="nucleotide sequence ID" value="XM_007877451.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLU4"/>
    <dbReference type="STRING" id="1069680.M7NLU4"/>
    <dbReference type="GeneID" id="19897236"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03549"/>
    <dbReference type="eggNOG" id="KOG0330">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_1_1"/>
    <dbReference type="OMA" id="GIGIKCC"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17954">
        <property type="entry name" value="DEADc_DDX47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044765">
        <property type="entry name" value="DDX47/Rrp3_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF20">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="51"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="245"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR08111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="450" mass="50501" checksum="CB92151FDBF9FC73" modified="2013-05-29" version="1">MLETVIYGNDSFNNEVSVKKNFKDLGLIDELCDICKALKFELPTPIQQEAIPWAIQGRDIIGLAQTGSGKTAAFALPIIQALWKKPSSLFACVIAPTRELAYQISDQFSALGSNLGLKSVVIVGGMDMVSQAIALNKKPHIVVCTPGRLQDHLENTKGFSLRTIKYLVLDEADKLLDMNFGPIIEKILKVIPRERNTYLFSATMTSKVEKLQRASLLNPVRIAVSTKYSTVSTLIQSYLFFPFKYKDTYFVFLINELAGQSIIAFARTCSDAQRLTILLRHLGFSAVCLHGQMSQSSRLGALTKFKSGSFNILIATDVAARGLDIPLVDYVINYDIPTDSKTYIHRVGRTARAGRSGKSLSLVTQYDLELFLRIEKALGNKMNEFSTDKEVVMLLNERVSEAQREAIIEMKNMYNTRAKKQTQKHKKRISKSMTVLAKRKRDDMDLDKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLX8</accession>
    <name>M7NLX8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3 10">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_03583</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GPI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="3 10"/>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875677.1">
        <property type="nucleotide sequence ID" value="XM_007877486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLX8"/>
    <dbReference type="STRING" id="1069680.M7NLX8"/>
    <dbReference type="GeneID" id="19897270"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03583"/>
    <dbReference type="eggNOG" id="KOG2446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017947_3_1_1"/>
    <dbReference type="OMA" id="DWYRQLW"/>
    <dbReference type="OrthoDB" id="5831190at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1390.10:FF:000001">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000004">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001211">
        <property type="entry name" value="PRK00179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469:SF1">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR08146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="547" mass="62416" checksum="B1C97FD26B9F3F4B" modified="2013-05-29" version="1">MNEMNSWNLLKKYYDEKGKKLVIKDLFESDKDRFQKFSKEFCCSSDDYILFDFSKNIIDDESFKLLVQLAKEANVEGLRDRMFSGDHVNFTENRSVYHIALRNTSKKKMEIDGKDVSSDVYSVLERMQEFSEKVRSGEWKGYTGKSIKTIVNIGIGGSDLGPSMVTEALKPYALRNLQVYYVSNIDGTHISEALRLCDPETTLFLIASKTFTTLETIANAETAKKWFLKTSRSEEHISKHFVALSTNVKEVTAFGIDSKNMFEFFDWVGGRYSVWSSIGLSVILYIGFDNFWQFLEGAHAMDNHFSDTPIEDNIPIIGGLLSVWYSNFFGAQTRLVSPFDQYLQMFPRYLQQLSMESNGKSIDRTGKQVQYSTGVILFGEPATNSQHSFFQLVHQGTILIPADFIMAIESHNSIEENKHQLLLASNFFAQSEALMLGKTSSQVEENETNLELIPHKTFTGNRPTTSILLKKVTPRTLGALIVYYEHLTFIEGAIWNINSFDQFGVELGKALAKNIYQELLSNEYVTNHDASTRNLINIFKMKSRQNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NM23</accession>
    <name>M7NM23_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease III</fullName>
            <ecNumber evidence="2">3.1.26.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_03362</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875444.1">
        <property type="nucleotide sequence ID" value="XM_007877253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NM23"/>
    <dbReference type="STRING" id="1069680.M7NM23"/>
    <dbReference type="GeneID" id="19897049"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03362"/>
    <dbReference type="eggNOG" id="KOG1817">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000907_1_3_1"/>
    <dbReference type="OMA" id="RAWGANQ"/>
    <dbReference type="OrthoDB" id="2392202at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035613">
        <property type="term" value="F:RNA stem-loop binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106410">
        <property type="term" value="P:box C/D sno(s)RNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030847">
        <property type="term" value="P:termination of RNA polymerase II transcription, exosome-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034474">
        <property type="term" value="P:U2 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19876">
        <property type="entry name" value="DSRM_RNT1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000001">
        <property type="entry name" value="Ribonuclease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044449">
        <property type="entry name" value="Rnt1/Pac1_DSRM_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF0">
        <property type="entry name" value="RIBONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="9">
        <location>
            <begin position="35"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="8">
        <location>
            <begin position="232"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="271" mass="30897" checksum="C9D3150350EE4C3A" modified="2013-05-29" version="1">MVKKDPFFLEMVSLVQNSLKIEFVKESEIPSLPEIKDPLLLKQVFTHRSYAYSTQSYNVSERDILKLHNERLEFLGDSYLNHAVTRLLFNAFPDAREGELSVMRSELVGNTKAEKISRLYGFDKRLLLSESAESDNVRSLKKIVADIFESYIGGLVLDSSNGEKIAFRWISQLMAPDISLFQKKQKNSVELDKMAKQTLYNRIGREYHTDGQTRKKIEYIWIGGEGGNKDGYEYSCRIDGQEVGRGWGPNQKIAGIRSAMDALAKLPSENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NM72</accession>
    <name>M7NM72_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">transketolase</fullName>
            <ecNumber evidence="4">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PNEG_03137</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transketolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875195.1">
        <property type="nucleotide sequence ID" value="XM_007877004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NM72"/>
    <dbReference type="STRING" id="1069680.M7NM72"/>
    <dbReference type="GeneID" id="19896824"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03137"/>
    <dbReference type="eggNOG" id="KOG0523">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_0_0_1"/>
    <dbReference type="OMA" id="ADYMRGS"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000004">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF2">
        <property type="entry name" value="TRANSKETOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="15">
        <location>
            <begin position="356"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="117"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMR08292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="681" mass="76203" checksum="223989F089B32C5C" modified="2013-05-29" version="1">MSLKMIIEKCVNTIRVLSVDIVSRSNSGHPGAPMALATSAHVLFNNHLLFDPNDPLWINRDRFILSNGHACVLQYILLHLYGYKITMDDLKHFRQLDSKTPGHPETLITPGVEVTTGPLGQGFVNAVGLSIAQTHLAATFNKPGFDIINNYTYCFFGDGCAMEGVLYEAASLAGHLKLGNLICFYDYNAITIDGDIECAFTEDVAERFRASGWHVLFVNDGNTDIASIDEAIIQAKRVKDQPTMIQLKTTIGYGSKYQGTASVHGAPLKEDDVVSIKEKFGFDPKESFVISDDVYDYCRKASFRGIEAHKAWLELFSEYEKQYPELAKELQRRINKQFPENFKQAFPTYKFTDPPAATRKLSEIVLTKISDILPELIGGSADLTSSNLTRCPNSVDFQHPSRKIGDYTGRYIRYGVREHAMIGIMNGLAAYGAIIPYGGTFLNFVFYGAGSLRLSCISHFRIIVVATHDSIGLGEDGPTHQPIEASAWLRALPNMMFWRPADGNECSAAYYVAITSLNTPSTIALTRQNLPHLENSSLDKAIKGGYVLYEDDFADLTIASTGSEVFLCLDAIKILKEKYNIRARLVSIPCFYIFDQQNFDYKLTVLKDNIPILGVEVYSTLGWRNYSHEQFGLDTFGASAPYKDIYDKHEFTPEGIASRAQKTVEFWKHIENIRSPIRRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NM95</accession>
    <name>M7NM95_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Iron-sulfur cluster biogenesis chaperone, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_01957</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria. Assisted by the DnaJ-like co-chaperone jac1 and the nucleotide exchange factor mge1, it mediates ATP-dependent Fe-S cluster transfer from the scaffold proteins isu1/isu2 to grx5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873934.1">
        <property type="nucleotide sequence ID" value="XM_007875743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NM95"/>
    <dbReference type="STRING" id="1069680.M7NM95"/>
    <dbReference type="GeneID" id="19895651"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01957"/>
    <dbReference type="eggNOG" id="KOG0102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_2_4_1"/>
    <dbReference type="OMA" id="MGTDWKI"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11733">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000020">
        <property type="entry name" value="Chaperone protein HscA homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000003">
        <property type="entry name" value="Heat shock protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000007">
        <property type="entry name" value="Heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="633"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="568"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR09773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="657" mass="71875" checksum="D36FDCCFEE4E862A" modified="2013-05-29" version="1">MLLRNIILKTLSNNYVKKGLYLVRKNSQKVQGQVIGIDLGTTNSCVAVMDGRLPRVIENSEGSRTTPSVVAFTKEGERLVGVAARRQAIVNPENTFFATKRLIGRRYDDVEVKKDIDQVPYKIIKYTNGDAWLEARGEKYSPSQIGGFILNKMKETAESYLGRPVKNAVVTVPAYFNDSQRQATKDAGSIAGLTVQRVVNEPTAAALAYGLDKETDKVVAVFDLGGGTFDISILELNQGVFEVKSTNGDTHLGGEDFDITLVRYIVDQFKKEQGMDLSKDRMAIQRIREASEKAKVELSSTVSTEINLPFITADATGPKHINIKITRSQLEKLVEPLIKRTIEPCRKAIKDAGIPFSSINEVILVGGMSRMPKVIETVRNVFGREPAKSVNPDEAVAMGAAIQGGVLSGEVKDIILLDVTPLSLGIETLGGVFTRLITRNTTIPTRKSQVFSTAADGQTAVEIKVYQGERELVRDNKYLGNFVLSGLPPAPKGVPQIEVTFDIDADGIVNVSAKDRGTGKDQSIVVAGSSGLSESEIQAMIDEASKYAEVDKSRKESIEAANRADTVVHDTQKALTDFEAQIEKEEADKIRSSISELRELIAKAQSGETISSDELKNKTSELQQDSLKLFENAYKKKQEAQQNQQSAEPAGNEEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMG1</accession>
    <name>M7NMG1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSM3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM3</name>
        <name evidence="11" type="ORF">PNEG_02039</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874019.1">
        <property type="nucleotide sequence ID" value="XM_007875828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMG1"/>
    <dbReference type="STRING" id="1069680.M7NMG1"/>
    <dbReference type="GeneID" id="19895733"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02039"/>
    <dbReference type="eggNOG" id="KOG3460">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_5_1_1"/>
    <dbReference type="OMA" id="FDSHCNI"/>
    <dbReference type="OrthoDB" id="29543at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01730">
        <property type="entry name" value="LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000036">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034105">
        <property type="entry name" value="Lsm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040002">
        <property type="entry name" value="Sm-like_LSM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13110">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="15"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="98" mass="11209" checksum="B6ED18005A9D5FB0" modified="2013-05-29" version="1">MNDIGIKTDNASVSEPLDLIRLSLDERVYVKLRGDREIKGKLHAYDSHLNMVLSDAEETVYTIDIDDEAEEHISTRKTHSEMIFIRGDSVILISPPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M7NML2</accession>
    <name>M7NML2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TFIID subunit TAF5 NTD2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_03290</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat TAF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875365.1">
        <property type="nucleotide sequence ID" value="XM_007877174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NML2"/>
    <dbReference type="STRING" id="1069680.M7NML2"/>
    <dbReference type="GeneID" id="19896977"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03290"/>
    <dbReference type="eggNOG" id="KOG0263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005884_0_2_1"/>
    <dbReference type="OMA" id="HNHPVWD"/>
    <dbReference type="OrthoDB" id="10266330at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08044">
        <property type="entry name" value="TAF5_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.500">
        <property type="entry name" value="TFIID subunit TAF5, NTD2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007582">
        <property type="entry name" value="TFIID_NTD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037264">
        <property type="entry name" value="TFIID_NTD2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF1">
        <property type="entry name" value="CANNONBALL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04494">
        <property type="entry name" value="TFIID_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160897">
        <property type="entry name" value="Taf5 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="TFIID subunit TAF5 NTD2" evidence="9">
        <location>
            <begin position="66"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="392"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="434"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="476"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="518"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="568"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="671" mass="76067" checksum="4F31C3BC9E3D81E5" modified="2013-05-29" version="1">MPPVVPNITQQNIGRTITIEDMNRLVMNWLSQHGYARTEAILRLESARGPEALNSAKNSLDWLNGNEDTYFQSYMLLRDWIDSSLELYRPELRRVLFPIFIHSYLDLISKNQINSAKQFFNTYSSEHEVLHGHDIRQISSITLPEHIEENELVKLYRQNKYRITMWRTAFDLMLHFLFENESNGGAIIMRLLNQHIETKIVTGRPDQFINSVVTNDEGISGYDVYHLDNFNKQPVKLGEMPLDTDLKNNIEIELASLDNEIEKTNEKCNKSFLEEFKNKKEISEDSPMKNSIPLPTFKGIDVEKEIEVIKDLRKRLILGPQASLPSVCMYTFHNTHDSLNCADISENASLIACGFSESYIRVWNTSINKTVSSDSTTPNDSVLYQKSHSRRFIGHSGPVYGIAFSNDNRFILSCSEDRSCRLWSLDTNTCLVAYKGHNQPIWDIAIGPFGHYFATASHDQTARLWSYEHMYPLRIFAGHLSDVDCVSFHPNSAYIATGSSDKTSRLWDVQKGSAVRVFTGHTGPINCVTISPDGKLLATAGDDGLINIYDIGLGKQLKSMKGHTRKSIYSLSFSKESSVLVSGGSDCTVRIWDVKRDTSNNKNISEISEGYNVETENNTLPKASTLTTKEKKENIKTPDHMTALYTCKTPVYKVQFTRRNLCLALSVSGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN81</accession>
    <name>M7NN81_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="13">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_02865</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874902.1">
        <property type="nucleotide sequence ID" value="XM_007876711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN81"/>
    <dbReference type="STRING" id="1069680.M7NN81"/>
    <dbReference type="GeneID" id="19896552"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02865"/>
    <dbReference type="eggNOG" id="KOG2431">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003818_3_0_1"/>
    <dbReference type="OMA" id="WDAYTKY"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF55">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="438"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="524"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="354"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR08687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="544" mass="63519" checksum="EA6A32483C1CCAD2" modified="2013-05-29" version="1">MSENINPVFQHKKRLFFLRFLQKKSWRYRKYIWIFLSIFLFIIFIIIKNETINPALTWKQKPFEEEDIWKIKQELVKQVFLHSWNGYKQYGWGKDQYSPISKRGYNSILPNGAGWIIVDSLDTLYIMGLDQELQDARNWVESSLNFNQDKYISTFEVTIRMLGGLLSAYFLTKDNLYLNKATDLSNRILNAFNSPSGIPYPSVNLRTGNVNDFGGYVYASTAEVATLQLEFKYISYLLKSKQHWEKAEKVMKVIKDNNLKDGLAPIFLDTSNGKFQNSHISLGSRGDSYYEYLIKQYLLTQKQEKVYLEMFEEAVEGIKKHMVNYSKPSGLTFVAELPNGIGNYISPKMDHLACFLGATLALGVTKGLDLKTKKQQNWTEQHESTFKLSEELTRTCFEMYNVTASKLSPEIVYFNLEDKNKEDIIIHNLDKYNVQRPETIESLFVLWRITKNITYREWGWKIFEAFKEYTKVDGGYTSVQDVLVNPPILGDNMESFWLAETLKYFYLLFSPDDVLPLDKIVFNTEAHPFPTFDLQSLGFNTSWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNB4</accession>
    <name>M7NNB4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_01457</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SCO1/2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873397.1">
        <property type="nucleotide sequence ID" value="XM_007875206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNB4"/>
    <dbReference type="STRING" id="1069680.M7NNB4"/>
    <dbReference type="GeneID" id="19895154"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01457"/>
    <dbReference type="eggNOG" id="KOG2792">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050131_0_2_1"/>
    <dbReference type="OMA" id="MLYFRVE"/>
    <dbReference type="OrthoDB" id="270009at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000013">
        <property type="entry name" value="Blast:Protein SCO1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017276">
        <property type="entry name" value="Synth_of_cyt-c-oxidase_Sco1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151:SF5">
        <property type="entry name" value="AT19154P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037736">
        <property type="entry name" value="SCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="128"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR10183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="31114" checksum="C89F462379E12BBF" modified="2013-05-29" version="1">MAFIQTKGTYRLLFQNNLKKSLFLIHNKHFLRLRFHFSTLNLQRNREKIGPFSWKSGSFFVMTGIFLVWYFKNEKKKVEQRRHLNKNISIGKPRIGSDFELIDHNGRNVTNKDFLGKYMMIYFGFTRCPDICPEELDKMASVINNVNSQRNLVTPIFITCDPNRDTPSQIKEYLKEFHTQIIGLTGSYENIKAVCKAYRVYFSTPPDVKPDDDYLVDHSIFFYLMDPDGHFVDVFGRQYNAQQITSKILQYINDWESSRGQIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NND7</accession>
    <name>M7NND7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tuberous sclerosis 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874957.1">
        <property type="nucleotide sequence ID" value="XM_007876766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NND7"/>
    <dbReference type="STRING" id="1069680.M7NND7"/>
    <dbReference type="GeneID" id="19896603"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02916"/>
    <dbReference type="eggNOG" id="ENOG502R01W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004261_0_0_1"/>
    <dbReference type="OMA" id="IMFLPHI"/>
    <dbReference type="OrthoDB" id="6022054at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007483">
        <property type="entry name" value="Hamartin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154:SF2">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04388">
        <property type="entry name" value="Hamartin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="702"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="868" mass="102588" checksum="E6DF0E18837E8752" modified="2013-05-29" version="1">MPNQSLTRLLKALHNLFSSSEIPQKLPSEINDKISQYLKNHDNPDFFEIQKLQEQLLDLYHMRVEHKNVSFQGLFICCLQKFRSLLIGKEYTEIWWNIIVKHVFSSCQQQRNTLLNAESILLSMMVLEEDTKDRLHKEKQESSEMIKRFLFEFYLNNSKEVFSSVLKNSFIEDKRRYISANIESILIGYAKQRTKAFFNDIDVYFVQKKYRLQILTLLCAFVRLQGPYLYTIFETPLFENLLHCLENDSSTTVISLSLTILVMFMPHICNLLGKYLPRLFKIYVRVLCWDRFGAIQKHYDVLDNELEIKNQEALQIFSQSNIEWEKLDSLFDISPTIPPNCVQFFTFIYGLYPLNFLKFLHSAQTYLKEKKDQYYMYFDDDMIRSRSESLVKRHIIHPNLLLFTFETEITDQTRWMKLEIADIVAKCVSLDIFNTPQLSSRNIDRQYKQNENNLSACFKPAESDTEQLKDSIFDRNRNHLMSHIFFSNPENIISSHFDSNLNQNIAPVKIDDMLKLYEQLNSNSDILATGQIDMSLNNLSLESKESLVLKSKTEKYVKDSVSSPLFSKTLESDATVASLKREILLLQNELNFEKYLKLQHLHHLSRLKREYILDLSVEAERQNLYNTTRALKSRLVNLQSTLDRLRSEAITRQNQRIKRETELNTKLKLLREEQKCLKSDYDIMSEKLEESQKNISYLSIQLQHSNSERFKLNQELKELKAEQLKNKKMEVSAYDNNEQKKIHLEESLKKKDELLESADKTIFVLNQRLQQKEHEYDIIKSQYNLLLIKSMDIPFHHIVNTEIADSNTFQEDRSLKLNNILLEEFNLLENAHQKLLLDYRAIQSEMISKNSQIEILQQKIAQYQSQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNH0</accession>
    <name>M7NNH0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 4E type 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873448.1">
        <property type="nucleotide sequence ID" value="XM_007875257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNH0"/>
    <dbReference type="STRING" id="1069680.M7NNH0"/>
    <dbReference type="GeneID" id="19895204"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01509"/>
    <dbReference type="eggNOG" id="KOG1669">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043552_3_1_1"/>
    <dbReference type="OMA" id="NSVEQFW"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF18">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E HOMOLOGOUS PROTEIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="28790" checksum="FD26AB553D533515" modified="2013-05-29" version="1">MPQEPDFFFSLTSSNVTPSNESPILKTNQFKKSDVSQSRNIQANINVQSPVHMLKHSFTFWYMNRAFGSKIKDYESSLKKLITFSSVEEFWSIYAYLKRPDTLPVISDLHLFKEGIRPIFEDPANQDGGKWTLRLRKGIAVRYWEQLVMAIVGDQFWNIGDELCGIVLSIRNSEDLISVWNRSSDNGRINLKIRDLIKQILNLPLDTILEYKGHKDSFVDMYNHYSSEKNSHFYEKMNIAKHKVIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNH8</accession>
    <name>M7NNH8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphopyruvate hydratase</fullName>
            <ecNumber evidence="3">4.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_02858</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Mg(2+) is required for catalysis and for stabilizing the dimer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874896.1">
        <property type="nucleotide sequence ID" value="XM_007876705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNH8"/>
    <dbReference type="STRING" id="1069680.M7NNH8"/>
    <dbReference type="GeneID" id="19896545"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02858"/>
    <dbReference type="eggNOG" id="KOG2670">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031223_0_0_1"/>
    <dbReference type="OMA" id="RCMMSHR"/>
    <dbReference type="OrthoDB" id="1739814at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.10:FF:000001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000002">
        <property type="entry name" value="Enolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF1">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00178">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="12">
        <location>
            <begin position="3"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="11">
        <location>
            <begin position="142"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="371"/>
            <end position="374"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR08681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="433" mass="46869" checksum="F706F2D89B9E01B1" modified="2013-05-29" version="1">MGILKIHARSIYDSRGNPTVEVEVTTETGIHRANVPSGASTGIHEALELRDNGSSWCGKGVTLAVSNVNDIIAPSLLSAGIDVKDQRSIDKFLNDLDGTSNKSRLGANAILGVSIAICKAAAAEKGVPLYRHFADIADTKEPFILPVPYFNVLNGGSHAGGRLAFQEFMILPTSAVTFQEAMQQGSEVYSALKKLSKKRYGHSAGNVGDEGGVAPDIQTADEALDLIVTAIEEAGYTGKIKIALDVAASEFYKNGKYDLDFKNPESDPSQHKTSKELADIYLDLSNRYPIVSIEDPFDQDDWNAWIYLSKHATFQIVGDDLTVTNVSRIKEAVDKKACNCLLLKINQIGTISESINACKTAFDAGWGVMVSHRSGETEDTVIADLVVGLGTGQIKTGAPCRSERVAKYNQLLRIEEELNHSVYASVNYIKNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNK7</accession>
    <name>M7NNK7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16 17">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="6 16 17">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PNEG_02619</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16 17">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16 17">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16 17">Belongs to the CDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6 16 17"/>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874638.1">
        <property type="nucleotide sequence ID" value="XM_007876447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNK7"/>
    <dbReference type="STRING" id="1069680.M7NNK7"/>
    <dbReference type="GeneID" id="19896310"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02619"/>
    <dbReference type="eggNOG" id="KOG1440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023471_1_1_1"/>
    <dbReference type="OMA" id="FFAYMYF"/>
    <dbReference type="OrthoDB" id="10260889at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006658">
        <property type="term" value="P:phosphatidylserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016720">
        <property type="entry name" value="PC_Trfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773:SF8">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, PHOTORECEPTOR-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018269">
        <property type="entry name" value="PC_trans_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14 16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 16" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR018269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMR08832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="395" mass="45405" checksum="F196440972B7F3DF" modified="2013-05-29" version="1">MKNRSNFFLRTVWTFAMIFGFLVIIAAGHIWIIVLLTFIQVIVFKELIAIVNISDKEKKLPWFRTLNWYFLCTTLYFAYGESLIYYFKHIVIVDAFLFSITTHHRFISFILYIGGFIFFVMNLKKGHYKYQFTQYCWTHMILLLIVGQSHFIINNIFEGIFWFLLPASLVICNDIFSYLCGKLFGRTQLIKLSPKKTVEGFIGGWVCTVVLGLTMGNIILHWNYMICPLRDLGATALIGLECIPNPTFTLQQFPLPEFIISYLALPYHTITIRPVEFHLMVFSTFASLIAPFGGFFASGLKRAFKIKDFGDSIPGHGGLTDRFDCQFINGFFVYLYYHSFIAVTHVSVGSVLQTAITSLTYDEQIKLSNSIYKYLVSKGVLSNAILECLRKSIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNR3</accession>
    <name>M7NNR3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Increased recombination centers protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873533.1">
        <property type="nucleotide sequence ID" value="XM_007875342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNR3"/>
    <dbReference type="STRING" id="1069680.M7NNR3"/>
    <dbReference type="GeneID" id="19895274"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01579"/>
    <dbReference type="eggNOG" id="ENOG502RTVH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031716_0_0_1"/>
    <dbReference type="OMA" id="LMFTINM"/>
    <dbReference type="OrthoDB" id="10261384at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034627">
        <property type="entry name" value="Irc6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28043">
        <property type="entry name" value="INCREASED RECOMBINATION CENTERS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28043:SF1">
        <property type="entry name" value="INCREASED RECOMBINATION CENTERS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10199">
        <property type="entry name" value="Adaptin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="29216" checksum="6D7D69EB886F732A" modified="2013-05-29" version="1">MVSKKILILGTPSSGKLTFLKELTGTLPEISSDRKNHAGIIHQIEFETKYYKKTVDIWIDEFQYEEIELWIKQYLSDEASQVREVLGAIIIVFRETKGPKFNEYVIKQVKEVKRIIEACGPLWDGVLLAIKVPEKNISDTNLTKYIDDKALSDACFNEGFEYVDLEYQSTNESKEGIERVREALEAYVWDEKLFDSIEDIFNENNEENMNKKGSEKDVEEFEKLASKIMALREQANLLPLSERQSFILKALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP10</accession>
    <name>M7NP10_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Ribosomal RNA-processing protein 8</fullName>
            <ecNumber evidence="9">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_02773</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the methyltransferase superfamily. RRP8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874803.1">
        <property type="nucleotide sequence ID" value="XM_007876612.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP10"/>
    <dbReference type="STRING" id="1069680.M7NP10"/>
    <dbReference type="GeneID" id="19896462"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02773"/>
    <dbReference type="eggNOG" id="KOG3045">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027694_1_1_1"/>
    <dbReference type="OMA" id="KWPTNPL"/>
    <dbReference type="OrthoDB" id="10258825at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106142">
        <property type="term" value="F:rRNA (adenine-N1-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2150:FF:000001">
        <property type="entry name" value="Ribosomal RNA-processing protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2150">
        <property type="entry name" value="Ribosomal RNA-processing protein 8, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007823">
        <property type="entry name" value="RRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042036">
        <property type="entry name" value="RRP8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05148">
        <property type="entry name" value="Methyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="303" mass="35520" checksum="6A87F3A1A4A29D62" modified="2013-05-29" version="1">MKQKKKNIEKKIRKNRNIKKDSLKVIRSRKFSKKEKKYIKKTQKQNNLSISETISTSGNKEINKFVEKIDKNTQLTRLQQKMKSKLSGGKFRLINEHLYNITSKEAMEFFKENPEMYEEYHIGFQNQISSWPKNPTDLIIEDLSEFINESRKMILKVADLGCGDAKIARTMKDISNIKVYSYDLVSRNSFVTKCDISNLPLKSSTIDIAIFCLSLMGTNYIDFLKEAWRILKMNGKLWIVEIKSRFMDNEGTAFCTALSSLGFSFVKKETSNKMFIYLYFKKTNKLNEKNFGILLKSCIYKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPD5</accession>
    <name>M7NPD5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRELI/MSF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874474.1">
        <property type="nucleotide sequence ID" value="XM_007876283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPD5"/>
    <dbReference type="STRING" id="1069680.M7NPD5"/>
    <dbReference type="GeneID" id="19896158"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02465"/>
    <dbReference type="eggNOG" id="KOG3336">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067902_1_1_1"/>
    <dbReference type="OMA" id="YCPWNEK"/>
    <dbReference type="OrthoDB" id="407630at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="181" mass="21180" checksum="2502088A6A6DF052" modified="2013-05-29" version="1">MKFFGTTFVFDYPWHQVSIAHWRKYPNERATHVVSIDTLRREIDPETGVLRTERLITCRQSAPHWILKFVGGGDSYVREVSEVDPRTNREMLIIRSANLTFSHVVSVEEQVVYRPAPDDPKHKTLFEQEATFQAMASFTRLVNTKMEEWSVRRFSKNARTGREGFEGVLAQIYEQREEQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPH2</accession>
    <name>M7NPH2_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_01311</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873237.1">
        <property type="nucleotide sequence ID" value="XM_007875046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPH2"/>
    <dbReference type="STRING" id="1069680.M7NPH2"/>
    <dbReference type="GeneID" id="19895008"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01311"/>
    <dbReference type="eggNOG" id="KOG2126">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004298_1_0_1"/>
    <dbReference type="OMA" id="EDEYVIM"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16023">
        <property type="entry name" value="GPI_EPT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037675">
        <property type="entry name" value="PIG-O_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="449"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="513"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="570"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="637"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="717"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="768"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="794"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="866"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="905"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="948"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR10608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="971" mass="112777" checksum="D62926C6518A6A5E" modified="2013-05-29" version="1">MLKHNIRNNQKWTFIKNFLLFFIFFSWFIFLHISGLYLFTQGFLLTRSTLNLTSRCDIPPYVFTNQEILKNDCWYPSTFKKAIIVVIDALRYDFTIENPGSSLYCHNIFTVLHETSTKHPRQAFLRPFIADPPTTTLQRLKALTTGTLPTFIDAGSNFAGTVILEDNILAQLKSRGYRIGFLGDDTWISLYPTYFEPNITYPFDSFNVWDLDTVDNNINSYLFPLLNDTERTKWDILIVHYLGLDHAGHKYGPNHYETARKLSEMDTNIRKIMSKLQNDTLLIVLGDHGMDEKGNHGGDSLDEVVSALWMYNKGSTLPEFPSNLTSISQLDFVPTLSLLMGIPIPYNNLGGPIIEAFFYNKNLNWKDYSRAAKITVYQIKRYIKSYKNIYGLDGFEDIKVDLDTENIEYKFSQNNFQNNEFWKKQFFKYITYQQMILNKFREIWVRFDIWRIIAGIIILFGDLLCQFLFYLNLNYLTEKINILGIILKSIIGAGICALLSKLSFVFLNVSNSALFGGCFVSILSFLSFFLKKAFFVQFPKSFSKSITILLIIVHGLILSSNSFIVWEEKIILFTISSIYTLIFFSVFSKHKKNIRISAIIRILLLFLTGRMTSLIRQCREEQQPFCKSTFFYNTRNFVISFCFLFLLAFIFLVLLPSTISHFLTNSKIHKGSRSSPFIGFKVGFILILAHSIIDFETLHFSQLKHFNNEKIQEIKMILVRIVLFTYLFIFHLIWIFLSFNNRIKGKSKLSNLLNLTFMLKTYTHKFTNIYNSNYFSFILSWFIILTILQKPLGVISFSFLLFQILLYIELLHLLQKNSSSEIDVILFALLGRSHFFSTGHQATLSSIQWDSAFLASKTIIYPLSPALILGNTFGSQIFIAISLPLLNFHMENNAIDATSNRLFEILQIFLLYHSMMTTSSVLFTALLRRHLMVWKIFAPKYMANAIELLLIDIILLFFTLGFSIINFFHHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPW1</accession>
    <name>M7NPW1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02489</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874498.1">
        <property type="nucleotide sequence ID" value="XM_007876307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPW1"/>
    <dbReference type="STRING" id="1069680.M7NPW1"/>
    <dbReference type="GeneID" id="19896182"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02489"/>
    <dbReference type="eggNOG" id="KOG0733">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_8_2_1"/>
    <dbReference type="OMA" id="GLWSTHR"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19530">
        <property type="entry name" value="RecA-like_NVL_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000081">
        <property type="entry name" value="AAA family ATPase/60S ribosome export protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000018">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000110">
        <property type="entry name" value="Ribosome biogenesis ATPase RIX7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000365">
        <property type="entry name" value="Ribosome biogenesis ATPase RIX7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="211"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="540"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="792" mass="89017" checksum="782D945C2C5FE9D4" modified="2013-05-29" version="1">MKGKARLSRCLDDKIREYLDEYFDQFLKAPSSLLEAYEYLQGRDSLLRRTKKQVLEMSIKRVLGEKGPGISNKLLGESLGDMKETEFFEKTAISCENLSKISIKKEERSVLDSEEDVLSQKELLKSGYSSLKNEKIMKDRSYDISMSKRKNKMEKSDIPSKRLRVNENYNPPKGILFDDLGGIDECIDEILEYIVMPLMHPEVYSYIGIQLPRGVLLHGPSGCGKTLLANAIASEIGLPFISISAPSIISGMSGESEKKIRDMFNEAKSIAPCLIFIDEIDVVTPKRENAQREMERRIVAQFLTCMDDLSLDKTGGKPVLIIGATNRPDSLDPALRRAGRFDHEICLNVPNEIGREKILRTLLKKVRLSGDFDYRKLAKMTPGYVGADLSSLITASGIVAIKRIFKLLQNNASLNEKTLSQSNMDSSSPLDKNNSRVSMTDLNSFISDSFQNTAIIQRFLKTYPNTLPNDVLSLMCITIDDFLEALPKIQPSSKREGFATVPDVTWADVGALESIRMEMQMAIVQPIKHPELYERVGITAPSGVLLWGPPGCGKTLLAKAVANESRANFISVRGPELLNKYVGESERAVRQVFSRARASAPCIIFFDELDAIVPRRDDSLPESSARVVNTLLTELDGLNDRRGIYVIAATNRPDIIDPAMMRPGRLDKPLFVELPSEDERYEILKTLTKKTPISSSVNLLQIAKDQRCQNFSGADLAALVREAAVLALQNTFFIDLFTEKMLQNDFQDIPLYIEQYHFDKAFLTIRPSVSDKDRDRYYNLNRRYGCLTTESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPZ2</accession>
    <name>M7NPZ2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872818.1">
        <property type="nucleotide sequence ID" value="XM_007874627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPZ2"/>
    <dbReference type="STRING" id="1069680.M7NPZ2"/>
    <dbReference type="GeneID" id="19894605"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00907"/>
    <dbReference type="eggNOG" id="ENOG502QQWX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_568718_0_0_1"/>
    <dbReference type="OMA" id="ASADFYW"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050872">
        <property type="entry name" value="PPR_P_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128:SF211">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="60"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="56457" checksum="F079604E15064C89" modified="2013-05-29" version="1">MNKYNKMKLFIQQKIKYSKHFRMLHNDSYILSKEIKMLLNRGNITDAIIKVRNHNQNVSCTVSWNHIIDYCMNNGRVNLAFKCFNEMKKRSHFPNSHTFTILLRGLSMNSKHPRSFSYAFHIYKSLWSSKYTDRLSIIHTNAMLQVCAVTKQSQAAFEVFEEVSKSNLVADSITYTILFNILSHENMKNINVYDKRQKLLRKVIEAWNMRGFVVDESLICSISLCFLQGKKRKDSDFVFTLVERFFGIKRMIPPLQEKADILINDFNLNPSLSESQYIKISNKGLNIILLACLLLKKEKYGIEYWDFIIKNYGLVPDYNNYYNYFLLLIRTKLRSTIDKVIENIIQKQVSLENNVILLYMKACNKNRTHSDYIIAKTILKIVILHKMKINLFIIDLFLQIANNTVSKDDILDLLNLLQQFDLKSLIFAISHIKNRHERNDAISAGIRICSNLIKYSKYLSENEYKDIQILKDRVLKMRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQH1</accession>
    <name>M7NQH1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_00571</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR10968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872466.1">
        <property type="nucleotide sequence ID" value="XM_007874275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQH1"/>
    <dbReference type="STRING" id="1069680.M7NQH1"/>
    <dbReference type="GeneID" id="19894269"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00571"/>
    <dbReference type="eggNOG" id="KOG0860">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064620_2_1_1"/>
    <dbReference type="OMA" id="TEQFHRS"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090619">
        <property type="term" value="C:meiotic spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032120">
        <property type="term" value="P:ascospore-type prospore membrane formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15874">
        <property type="entry name" value="R-SNARE_Snc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR10968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="125" mass="14262" checksum="9BE83EC702E84072" modified="2013-05-29" version="1">MIPEDLHEPLGSHAANNSSYGPGNSRTAMIQAQIDDTVGIMRENINKVAQRGERLDILQDKTENLATSAQGFRRGANRVRKQMWWKDVKMRMCIIIGVIILLAIIIVFLEWLYFFFNDSIGSFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQJ3</accession>
    <name>M7NQJ3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">26S proteasome regulatory subunit RPN2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_02316</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the proteasome subunit S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874316.1">
        <property type="nucleotide sequence ID" value="XM_007876125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQJ3"/>
    <dbReference type="STRING" id="1069680.M7NQJ3"/>
    <dbReference type="GeneID" id="19896009"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02316"/>
    <dbReference type="eggNOG" id="KOG2062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IMFGRQE"/>
    <dbReference type="OrthoDB" id="261572at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000017">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016642">
        <property type="entry name" value="26S_Psome_Rpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048570">
        <property type="entry name" value="PSMD1_RPN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040623">
        <property type="entry name" value="RPN2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18004">
        <property type="entry name" value="RPN2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21505">
        <property type="entry name" value="RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015947">
        <property type="entry name" value="26S_Psome_Rpn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="9">
        <location>
            <begin position="6"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome regulatory subunit RPN2 C-terminal" evidence="8">
        <location>
            <begin position="757"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="929"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="929"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR09366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="953" mass="107084" checksum="FBE1AFB39E0D2980" modified="2013-05-29" version="1">MEGIQSVGGVLSLLDEKETDLQIHALKKLNELMDNFWHEIADEISKIETLYEDEKFPKRQLAALVASKVYYHLGEYNESAIFALGAKEWFDLSSSSEYVETIISKFIDTYIEKNFQKYEDSKTMIDERLITIAEKMFQRYLDNKQWKQVLGIALEARKLDIIEEVINKNQDEPLKNYLLDVSINLVQNLDFRNKVLSLLLDLFLKDKQPDYFSVIKCVVHLRNSDIAAKILQNLILKNDEKNLLIAYQIAFDLNDSATQEFLQKVSQNFQLLLKESEDENDMNKDLKDTIASRIKSILEGEESVKLYMKFLSQNNHADNQILVKTKDSLDARNSIFHSSITFSVAFMNAGTTSDKFFRQNLDWLSKALNWSKFSATAALGVIHRGDLSQGFSLLSPYLPQEGMSGSPYSEGGSLFALGLIHANHGKSVLHYLRTQLKNTQSEIIQHGAALGLGVAGMATGDEEIYEDLKNVLFTDNAVAGEAAGLAMGLVMLGTASPRAIDEMLQYAHETQHKKIIRGLALGIAMLMYAKEETADVLIDQLCSDLDPILRYGGIYTIAMAYCGTENNKAIKRLLHTAVSDVNDDVKRASVISLGFILLRNSFTLPRMVELLSESYNPHVRYGAALSLGIACAGSSMQDALDILEPLSKDPSDFVRQSAHISTAMILIQHNDQSNSRVVNFRKKLEKIISDKHEDAMAKFGAALAQGILDAGGRNVTIGLQSTIGSLNMIAIAGTAIFTQFWYWFPLTHFLSLSFTPTALIGLNKDLKIPKFEFISNAKPSLFAYPPETKKETDKGPGKVATAVLSTTAKAQARAKKTEKEKISKENDDDTMEMDTNFYDILESMPENMDTEEIKEIKDDNINEKNIIKKDEPLFEIMQNMSRVTPFQLKYISFKNNSRYIPVKKPTGGILMMMNKYPDEPEVFIDSALEDISGEEQELEADPPEPFEYSGFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQJ6</accession>
    <name>M7NQJ6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874320.1">
        <property type="nucleotide sequence ID" value="XM_007876129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQJ6"/>
    <dbReference type="GeneID" id="19896013"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02320"/>
    <dbReference type="HOGENOM" id="CLU_1225214_0_0_1"/>
    <dbReference type="OrthoDB" id="10457446at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082289" description="CFEM domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="7">
        <location>
            <begin position="33"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="226" mass="25454" checksum="CD7BCD9623B4BAC5" modified="2013-05-29" version="1">MLSPLIFVYFFIFIVSVSAKSHCVDHLADSQYLSDISKECYRSVIKTSSCRGIYDIKCICSSENYKLDIFSCILEKNRIDGYNMAVFFQETCKDLKNISKDCLEKKKKPVPEKTLSVAEQNVVFDPFLSIDDFMAQVRQEMEKDMAQKCIEQGNCKGRFDSTCSILYMFSTPQGSATKTASVKASQTDGSVLLNFASTDLGLFSSFSNLIKLFIAVISLMFLSIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQJ9</accession>
    <name>M7NQJ9_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02132</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874114.1">
        <property type="nucleotide sequence ID" value="XM_007875923.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQJ9"/>
    <dbReference type="STRING" id="1069680.M7NQJ9"/>
    <dbReference type="GeneID" id="19895825"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02132"/>
    <dbReference type="HOGENOM" id="CLU_1960498_0_0_1"/>
    <dbReference type="OrthoDB" id="5387342at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031632">
        <property type="entry name" value="SVIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15811">
        <property type="entry name" value="SVIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="128" mass="14803" checksum="5A3A7536E90B8170" modified="2013-05-29" version="1">MGIICCKIKKYTETFSESCEQQKTDEKMKIPISSKKNKSKSSKKGYMLSKEKNIEKTEHDIAFLREATANAAQARFEKNKSKGICTPGKLSSQLAAEKKKTRLELLEDISREKQIERDQKQKNDLRWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQP9</accession>
    <name>M7NQP9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_00652</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872550.1">
        <property type="nucleotide sequence ID" value="XM_007874359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQP9"/>
    <dbReference type="STRING" id="1069680.M7NQP9"/>
    <dbReference type="GeneID" id="19894350"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00652"/>
    <dbReference type="eggNOG" id="KOG2808">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039675_0_0_1"/>
    <dbReference type="OMA" id="SFAQVRW"/>
    <dbReference type="OrthoDB" id="10261918at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039979">
        <property type="entry name" value="PRPF18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007:SF19">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="11">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Prp18" evidence="10">
        <location>
            <begin position="189"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="125"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR11053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="338" mass="40075" checksum="02945CA241C44A06" modified="2013-05-29" version="1">MNLLTAEISRKREEIKNVTSQNSQKYIKQGDLEKKREKAYYEEKERMDNEKEEQRKKKRELLAQEEEKRVLFKKRYQESRLEKQNELLMKDISEEELIKKFREKNQPICLFGETFEDKKERLIILECVEERKKKQDEMLGNVESEGKAIELKDEIEALRKEAENDESVLKINLNELKNNPENLYKKILVYFEILIELWKKTLDERPDEIKESKQGKSVSANQQQSQKDLQVFFNLLKKKSMKSDILEGVSKITYHCQRREYIKANDAYLQLSIGNAAWPIGVTMVGIHERSAREKLHTGQTGHVLNDEATRKWLQAIKRLLTFIQTVKPPNDRNQLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQZ7</accession>
    <name>M7NQZ7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small ribosomal subunit protein mS35 mitochondrial conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873838.1">
        <property type="nucleotide sequence ID" value="XM_007875647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQZ7"/>
    <dbReference type="STRING" id="1069680.M7NQZ7"/>
    <dbReference type="GeneID" id="19895559"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01865"/>
    <dbReference type="eggNOG" id="KOG3933">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072379_1_1_1"/>
    <dbReference type="OMA" id="AMNLKWA"/>
    <dbReference type="OrthoDB" id="283424at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019349">
        <property type="entry name" value="Ribosomal_mS35_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039848">
        <property type="entry name" value="Ribosomal_mS35_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10213">
        <property type="entry name" value="MRP-S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS35 mitochondrial conserved" evidence="1">
        <location>
            <begin position="101"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="222" mass="26838" checksum="C207D0732305C31B" modified="2013-05-29" version="1">MFLNIFIRSLLNYSNSFLKIRCFSSKSLDSFSVLKKPLNYTYERRLKRRKDDNNVEKRMKEYKFDDITSLAHDYLDEHREIREYYRKIAWELPTLTKFSMKYEVPGKEDILKFRYTTYLGEKHPAESKVTMEVLLNNLGLSLVERHKLIVLSGPRYNPLTDVLKFNCELFPERDENKKYLNEQLKKLIEEAKDLRDTFEDIPQDFRHVKSKTSITFPKEWIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M7NR01</accession>
    <name>M7NR01_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873843.1">
        <property type="nucleotide sequence ID" value="XM_007875652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NR01"/>
    <dbReference type="GeneID" id="19895563"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01869"/>
    <dbReference type="HOGENOM" id="CLU_1390768_0_0_1"/>
    <dbReference type="OrthoDB" id="5353123at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR09682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="196" mass="22377" checksum="40E0636F016E085E" modified="2013-05-29" version="1">MCFNLLNTHEKPMNNKTKSCMCLPLSCLNEKSCKRKCEVMGLSNEQSDLDSYDCFFGNEMPVYMGKPHGSSKVNDFVLKGSPNIGKKMQKDIEVDRGTLKDIFQINPQYGDRSVGEIIKGLSKNSSSLRTLELNKLFNDPLDNESRYTDLITMNVNPQQILGKDSFNLLNRELGTIPENEVLHCFYTTYYRTDPHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRD6</accession>
    <name>M7NRD6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamine synthetase</fullName>
            <ecNumber evidence="3">6.3.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamate--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_01873</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10 11">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873847.1">
        <property type="nucleotide sequence ID" value="XM_007875656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRD6"/>
    <dbReference type="STRING" id="1069680.M7NRD6"/>
    <dbReference type="GeneID" id="19895567"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01873"/>
    <dbReference type="eggNOG" id="KOG0683">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036762_1_1_1"/>
    <dbReference type="OMA" id="DRRPNAN"/>
    <dbReference type="OrthoDB" id="1936100at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF57">
        <property type="entry name" value="GLUTAMINE SYNTHETASE 2 CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="12">
        <location>
            <begin position="22"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="13">
        <location>
            <begin position="108"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR09686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="353" mass="40271" checksum="C6A33A057916978F" modified="2013-05-29" version="1">MEKDKNVSNLLKYMILEQHGKIQAEYVWIDGSNELRSKTITLDKKPKSVSDLIEWYFDGSSSGQASGNDSDVYLRPVAFYPDPIRQGDNIIVMAECWNPDGTPNEYNYRYACSKLSEKYIKHEPWFGIEQEYTLLDKYGAPYGWPRGGFPAPQGPYYCGVGTGKVYCRKIAEAHYRMCLYAGIKIAGINAEVMPSQWEFQIGPCLGVTIGDDLWIARYLLVRIAEEFDVKISFHPKLVKQFNGAGCHTNFSSIEMRKEGGMEHILNAISKLKKKHEEHIKVYGEDNNQRLIGIHETGHIDHFSYGIADRTASIRIPRICAKQGYGYFEDRRPASNIDPYRVSSIIMETVFSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRT9</accession>
    <name>M7NRT9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01755</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873719.1">
        <property type="nucleotide sequence ID" value="XM_007875528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRT9"/>
    <dbReference type="STRING" id="1069680.M7NRT9"/>
    <dbReference type="GeneID" id="19895449"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01755"/>
    <dbReference type="eggNOG" id="KOG2898">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048121_0_0_1"/>
    <dbReference type="OMA" id="EKFTRWR"/>
    <dbReference type="OrthoDB" id="272512at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF60">
        <property type="entry name" value="LYSOPHOSPHATIDIC ACID:OLEOYL-COA ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="10">
        <location>
            <begin position="97"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="301" mass="34901" checksum="6A0892AB7E4ECE45" modified="2013-05-29" version="1">MEKFTKWRDEGTGLAPFFQNSFEIESPKCFFLIFGSFLYIIRHLFIFFLFINYFIFVHMLLSPIFQPIFPRLVHFVKKIFIGSVFFLCGISLSSVQINYTKKKKIFPCAQNIIISCYCSPLDILCLSFNYNPIFTISFSNTSFVQHVSGIKALFYTFSMPERSPYKNYMTLDSLSKLYPNRIICVFPEGTTSNGSGLLLFTQSLESVAPKTKIFPLSIKYGNYLTTPLPRSFFKFLFRFTFKLRHNFQIKISETPIIVEHPEKLREIASAALSRLSKVPRLGLGVNEKISFLKAWKTFSKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRU6</accession>
    <name>M7NRU6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_00488</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872374.1">
        <property type="nucleotide sequence ID" value="XM_007874183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRU6"/>
    <dbReference type="STRING" id="1069680.M7NRU6"/>
    <dbReference type="GeneID" id="19894186"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00488"/>
    <dbReference type="eggNOG" id="KOG0588">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_355692_0_0_1"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14081">
        <property type="entry name" value="STKc_BRSK1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000394">
        <property type="entry name" value="Serine/threonine-protein kinase HSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.220">
        <property type="entry name" value="Fungal kinase associated-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031850">
        <property type="entry name" value="Fungal_KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043024">
        <property type="entry name" value="KA1_sf_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16797">
        <property type="entry name" value="Fungal_KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="32"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR11473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="789" mass="91072" checksum="A18F20822985A84E" modified="2013-05-29" version="1">MVRVKKMSYGKGLEVKKSDVKEKERRTHIGPWKLGKTLGRGSTGRVRLAKHSITGQLAAVKIVPKTICVERSKAEKGRGKSNVLHGIEREIVIMKLIDHPNVMRLYDVWENRHELYLILEYIEGGELFDYLVQKGKLDESEAVGYFCQIIAGVDYCHRFNICHRDLKPENLLLDKHRNIKIADFGMAALQPLDRMLETSCGSPHYASPEIVAGKIYHGAPSDIWSCGIILFALLTGHLPFDDENVRHLLLKVKAGHFVMPSRISLEGKDLIRRMLDVNPHTRIKMADILNHPFLLKYRHLDNFQDIPKSPTLDELRYPVRKRSEIDVEILKNLQILWRDVSKEVIINKLLSKEQNPEKTFYYLLLKYREDRMYYYKNYLDSVDSRKSSVSYISKLPLYDQKSLSLYKHLKRSSSQYSKSSVSSSKKNIHKGSNIVVNMPHKRGVDFTYVKKKKNSVCFEHKNVSIQNGSDASDPSSLFEEFAAECETAFNQSVISNIDWKNSLSHVPKIPSLKQDFQLFHIHPSSVISKEFGNDKMAPKIYEENPESTDLKKNHRSNDLNSSEDIGHFKYFIVKNQPKLRVSSLPEFITGKYKLFDERRAVSAPTDSSDVTRNKNKKSIFFWEKRGSGISSLRMVYPTAIFRRISRSKGHKENKISNQKIVDSEIHQSFFAKVLNIKPSVKLLKTILPFEHLYQEIVNTLRRWEYLGIGITNVREDIQSYIVYANISNCNAMKLKAIKFHVQVLKEGNGSVVRFFLEKGINSSFQQLVKEFELILENKHVLDFSDCVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRZ7</accession>
    <name>M7NRZ7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Transcription elongation factor Spt6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_01805</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. Essential for viability.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SPT6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873774.1">
        <property type="nucleotide sequence ID" value="XM_007875583.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NRZ7"/>
    <dbReference type="GeneID" id="19895499"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01805"/>
    <dbReference type="eggNOG" id="KOG1856">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001680_0_1_1"/>
    <dbReference type="OMA" id="GYFYLCF"/>
    <dbReference type="OrthoDB" id="995477at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001073">
        <property type="term" value="F:transcription antitermination factor activity, DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00164">
        <property type="entry name" value="S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09928">
        <property type="entry name" value="SH2_Cterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09918">
        <property type="entry name" value="SH2_Nterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2740:FF:000002">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.850:FF:000001">
        <property type="entry name" value="Transcription elongation factor spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000056">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000065">
        <property type="entry name" value="Transcription elongation factor SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2740">
        <property type="entry name" value="Spt6, Death-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.850">
        <property type="entry name" value="Spt6, helix-hairpin-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="entry name" value="YqgF/RNase H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049540">
        <property type="entry name" value="Spt6-like_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028083">
        <property type="entry name" value="Spt6_acidic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042066">
        <property type="entry name" value="Spt6_death-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032706">
        <property type="entry name" value="Spt6_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028088">
        <property type="entry name" value="Spt6_HTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035420">
        <property type="entry name" value="Spt6_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035018">
        <property type="entry name" value="Spt6_SH2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035019">
        <property type="entry name" value="Spt6_SH2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028231">
        <property type="entry name" value="Spt6_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055179">
        <property type="entry name" value="Tex-like_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017072">
        <property type="entry name" value="TF_Spt6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145:SF6">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14635">
        <property type="entry name" value="HHH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14641">
        <property type="entry name" value="HTH_44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14633">
        <property type="entry name" value="SH2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14632">
        <property type="entry name" value="SPT6_acidic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21710">
        <property type="entry name" value="Spt6_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22706">
        <property type="entry name" value="Tex_central_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14639">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036947">
        <property type="entry name" value="Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158832">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="S1 motif" evidence="13">
        <location>
            <begin position="1049"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="989"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR10052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1368" mass="159535" checksum="8219091D1AA93C05" modified="2013-05-29" version="1">MEYKDPEDEENQNEDWEEKEGENDEEDSSDDDIDSSEEDEEEQRKVQEGFIVDDDEEEEEEGDEDVIKIRHKRRKRTNDKDRNMDNEELDEEDLDLVMENTGIFMARDEPKFKRLKRRKEKFRSKDLADIFSDKDESDVDERAYVKSVGFSDEFADFIEDDDFGDDLDDEKENRHEKAFHGEIYSKSIGIDSDAHAQVFEIFGDGGDYAYALENEDSEQYEKKDISLYDVFEHSEIVERMLTDMDEIIRITDIPERMQILRAPYYHLQLSDDDILKEYEWISSRMLLMRTDIDSSLEKPFRKAVKNVIDFYINDFFEPSFIWQNRKDYLLFSEKSDDERKTTKVHTLLRQGDLWKILDLDVKFRSLVEKRNFLFETFKNFNINDKLFEEYIDKIESLEEITDLHDYIYFRYSENIKDMNISQGFTFKRPSNKYSFYAKIRKEDFYNLVRAFGLPPEHIGKNFLENTKRYFPEDPDKWPEILAGKYIVNSNYSSATVALAVARRLVVDELFNDPQVRKAIRTIYFRKGYIDVEPTEKGIRKIDNDHPFYFFKYARHISMENMTHNPDFYLQMINAEDQDLVKIRIHLDGYDNLFYEMFELLTSDNVSEIASAWNDQRKLILTDLFDKIIPIIEKTIKENLKSDCEDALAFFCRKKFLDKLDRTPYPVKSLDKGEVPRVLTVSNGRGDATKDDTSCVFVNEDGKVLEHIRISDIHEENSKKELSDFIKRRNPDVIGVSGFSISVEFLRKSLKDLVDNINIEQNDNSNHIRVVYVNDDVARLYQNSERANKEFPNLSSLGKYCVSLARYMQSPLMEYAAMGNDITSISFHPWQHLIPQDKLQRVLETAIVDIVNLVGVDINDVVKSSYKLNLLPYVCGLGPRKAQSLCKRISAVGGYISNRAEFITKSILTKNIFINCASFFKIPYDDNSISDSSEILDSTRVHPEDYELARKMAADALELDEEDVEEYDSSGGVVAYLMNDDPDKLSDLILEEYAEQLEKAFQQLKRNTLETIRDELQNPYEELRKDYKDITDQEIFTMLTGETPESLKPGSVIPVTVKKIGSKHVTVRLNCGIDGNISSSQVTDNYNLLPSQVLQYGHTVQAVVLSLNFQKFTVELSTKASSIKEAYKNQKDSSLNRKFKWDSIAEEKDKSKIALRREAEQRITRVIKHPLFRPFNARQAEDYLAGMQRGDVVIRPSSSGPDHIAITWKVSEGIYQHIDVLELDKENEFSVGRQLRVRGKEQNYFYSDLDELIVSHIKSIARKVDEMTTNEKFQKGTRAETEQWLNRYSEANPRRSCYAFCFNPKYPGFFDLCFKANLKSKVVSWSVKVVPNAFSLKGNLYGDMNTLCNGFKMMFAAQANNRSMTNNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NS17</accession>
    <name>M7NS17_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit BET3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01666</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Golgi apparatus</location>
            <location evidence="1 8">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873628.1">
        <property type="nucleotide sequence ID" value="XM_007875437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NS17"/>
    <dbReference type="STRING" id="1069680.M7NS17"/>
    <dbReference type="GeneID" id="19895360"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01666"/>
    <dbReference type="eggNOG" id="KOG3330">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087110_0_0_1"/>
    <dbReference type="OMA" id="MVQMQVQ"/>
    <dbReference type="OrthoDB" id="10262857at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14942">
        <property type="entry name" value="TRAPPC3_bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000001">
        <property type="entry name" value="Trafficking protein particle complex subunit BET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016721">
        <property type="entry name" value="Bet3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018293">
        <property type="entry name" value="TRAPP_I_complex_Bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="186" mass="21222" checksum="E9103DC0C87193E8" modified="2013-05-29" version="1">MSKTKLGEEFWKKTEKVNAELFVLTYGSIVAQLCKEYDDYAQVNKELDNMGYNIGVRLIEDFLARTNIGRCKDFCETAEVIAKIGFKLFLNITPTVTNFSPDNKQFSLIFDENPLSDFVELPDDGRAQDELWYSNILCGVLKGALEMIQLQVEAHFVSDVLRGNDHTEMRVVLIKVIDDELPLSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSC4</accession>
    <name>M7NSC4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PNEG_00091</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871948.1">
        <property type="nucleotide sequence ID" value="XM_007873757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSC4"/>
    <dbReference type="STRING" id="1069680.M7NSC4"/>
    <dbReference type="GeneID" id="19893789"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00091"/>
    <dbReference type="eggNOG" id="KOG3359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008438_0_0_1"/>
    <dbReference type="OMA" id="NCHLNAP"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097586">
        <property type="term" value="C:dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p homodimer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900101">
        <property type="term" value="P:regulation of endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23285">
        <property type="entry name" value="beta-trefoil_MIR_PMT4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF51">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="578"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="615"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="645"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="700"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="314"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="383"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="445"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMR11653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="750" mass="89118" checksum="1D7E0252100F5DD6" modified="2013-05-29" version="1">MESFLRNRIKKTEIIEKIEEKDEIKKEKKSKKFFTYEFVFVIIFILSFLTRFYDIHHPSEVVFDEVHFGKFMSLYLRRTYFFDVHPPFSKLLLAFFGWIIGYDGHFLFENIGDSYIENSVPYVYIRLVPAFFGAMVVPLVFLIMKHSGHSLLSSTFAASLVLFDNAQVTQSRLILLDSILIFLMTSTLYCYIRFSNIRYLEFSFVWWKWLFLTGLFLSCTISTKYIGLFTYMAIGVMVVIDLWDLLDIRKGYTLNYFTKHFIARAISLLVFPFILYLLWFYIHLSILSKTGPGDRFMTPSFQETLDGNILSSSSIEVNYYDKILIKHKETNAFLHSHTARYPLRYNDGRISSQGQQVTAYIHNDTNNHWIIEPAYLSNETLLKKRVLNNDYIRLKHVSTDTYLLTHDVASPRYPTNQEFTTISNQLKDRYNETIFQIKCEYDKNNSVLKTKGKTFKLIHKLTGVAMWSNKDPLPDWAFKQQEVNGNKKIKQEHNIWLIDEIVDLNDTSREIKNYTLRSLSFFKKYIELQFSMLRHNNLLTKSHPYSSYPIEWPILNRGISFWTKESEFKQIYLLGNPLGWWFTFSFTIIFVIVIISDQILLRRGLNLIKESRELFYNYTTFFFFSWMLHYFPFYLMRRQLFLHHYLPAHICSALLSGSLFQLLFEKHSKSLISSYFFKKNKDKINIGREKIINTQNKAKIMFMILTSSLLACFIFFSPFTYGKPGLTSNELYKRKWSPNWDYAYLKYIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSK4</accession>
    <name>M7NSK4_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00162</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872023.1">
        <property type="nucleotide sequence ID" value="XM_007873832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSK4"/>
    <dbReference type="STRING" id="1069680.M7NSK4"/>
    <dbReference type="GeneID" id="19893860"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00162"/>
    <dbReference type="eggNOG" id="ENOG502QQZD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005863_0_0_1"/>
    <dbReference type="OMA" id="NMYTPGC"/>
    <dbReference type="OrthoDB" id="2503993at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902929">
        <property type="term" value="C:plasma membrane of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024982">
        <property type="entry name" value="Rax2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048266">
        <property type="entry name" value="Rax2-like_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048265">
        <property type="entry name" value="Rax2-like_third"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778:SF2">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12768">
        <property type="entry name" value="Rax2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20842">
        <property type="entry name" value="Rax2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20843">
        <property type="entry name" value="Rax2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082617" evidence="2">
        <location>
            <begin position="21"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1144"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like second" evidence="4">
        <location>
            <begin position="223"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like third" evidence="5">
        <location>
            <begin position="380"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like C-terminal" evidence="3">
        <location>
            <begin position="890"/>
            <end position="1134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR11728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1205" mass="136119" checksum="840A7C0E2769DB5D" modified="2013-05-29" version="1">MLRLVLKIILLFFLVNKAVSVTNITIPDIDLSKYGQTVITGDFSGISLYAYNERGRIHEESNRYKNELFMQVPNRTYISLGIVNGFINVISIIKDGKNIYAVIAGHFSRIGDVNTNSIVFYDLIESKFVTLKEGISNGYIKSIYYDEKNRHLYVGGSFRYNNSLNAIIWDLSNNEWIELPFKGFNGIVNTITRMNNGNILFGGQFEDAFSHGGGTHFVLNNYDRQVLNLHTAMILSEHSSLNEKYANPRNIICTNTYKNTTSWLLEKSEIGKWLALFRYVFRPQKIRFKNSDVQDYATKIFRVISFPIHGIMNLSYTDPVTKKIAFCEALCPLQQSSLEYQEFDFVNIIPMTGFRIEIIDWYGKGGGLKEVEVLLSDIQTFAVNTFNEPICVNESLRSNSYVTGGPWEVLRINDQSYLSANISRSALEKSSVVFEPRLQRSGYYHVHLYTPGCIQDNTCSFRGIVQVRIYYQENVNPVIVIVHQTQNYEKIDNIYKGFISGITSTFRPCVVIIPIQGQREYINVVALAVKFIPVSIFSSSNGLFEYNPSNYSLNAEKQSESKSVVDIARSLLSKNAIISSVIHDSSQTIIAGRFTNNEKPPFSNILRITPQVSSLAYGGVNGEIFSMLLHNNILYIGGRFNKILHSSSDAINNVVSYSIIDDSWTSLLWGLNGVVYNIYKYVASVNNTFKIYIAFSGNFRQILSFQNRKLSDVNGFALWDPEDKKWETNIDLFIDGQIQNSVLVSNNISLVSGNIRTLHSLRALGATALHISKSAHSLSPLFYSKAITPFFNLIVKRDIDKSSKNSIYTGAFYKFLSRPLIILGGQFEFENDENELIKNIAIIYNSKISGININLDPQSVILSLVVYNNILYIGGRLYHKINKESINGIFAYNLKEKRSYQLLPLSGDDTQVNILSMRPKSNELIIVGKFDSGKSSSCNGFCIFETSSNELRSSSSGFSGEVTALYWIDEKSVLISGNIKVNATLLNVAKYDFDTLTWSPVLPEKIYLPGPATSIIYDKNDKNSIYFSGKKRNGNAYFNKWNGRTLLQLDSELLPGSIINHMRIVSLKQRHRRNNVVPEDVTILVLGSLIFSSFGTVTAAFYDGNAWTPYLISSTLTGQPGIANSLFFEHEIYSSSRKYLAKGYVVLISLSISLSIIFLMTLYRAIFTNYQRKKGSLQIPYFPKEKELHKTPLTGISNDSDRDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSM6</accession>
    <name>M7NSM6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase</fullName>
            <ecNumber evidence="3 12">2.4.1.131</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_01404</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the fourth and fifth mannose residues to the dolichol-linked oligosaccharide chain, to produce Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:29523"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="EC" id="2.4.1.131"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11 12">
            <dbReference type="Rhea" id="RHEA:29524"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.131" evidence="3 12"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873340.1">
        <property type="nucleotide sequence ID" value="XM_007875149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSM6"/>
    <dbReference type="STRING" id="1069680.M7NSM6"/>
    <dbReference type="GeneID" id="19895101"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01404"/>
    <dbReference type="eggNOG" id="KOG1387">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017896_1_1_1"/>
    <dbReference type="OMA" id="ARLYGWV"/>
    <dbReference type="OrthoDB" id="2276068at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03806">
        <property type="entry name" value="GT4_ALG11-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038013">
        <property type="entry name" value="ALG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031814">
        <property type="entry name" value="ALG11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919:SF1">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15924">
        <property type="entry name" value="ALG11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="ALG11 mannosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="7"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="13">
        <location>
            <begin position="221"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF15924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR10126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="436" mass="51099" checksum="FB3B400EE413D1FC" modified="2013-05-29" version="1">MSQRPIIIGFFHPYCNAGGGGERVLWTAIKAIQSEYSHIICVVYTGDINSKKRDILEKTKEIFEIELDEKRIQFIYLYKRHYVSPERWPYVTLLGQSLGSLILAYEAINQCVPDIFIDTMGYAFTYPLISSCLDIPIVAYVHYPTISQDMISKLSNKRILKNVYWKMFALAYSFCGHYANLVITNSSWTQAHIESLWKKKKEIITIYPPCNIKELYDSSINQKIEREKLILYIAQFRKEKNHKLLLESFKTMLDTYPKTRDSGIKLILIGSIRENDEPYIDSLKNMTKHLNIDDRVLFFHNLSWKEIVTWLKKSWIGVNTMWNEHFGIAIVEYMAAALIPVIHDSGGPKLDIVVDYKGKPTGYHASTPSSFAKAFNDIFSMSQEDIDSMRKRAKESSIRFSQETFCNRWLDIMDILLKYEQTHRRERIYRTQFREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSM9</accession>
    <name>M7NSM9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Essential protein Yae1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01409</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873345.1">
        <property type="nucleotide sequence ID" value="XM_007875154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSM9"/>
    <dbReference type="STRING" id="1069680.M7NSM9"/>
    <dbReference type="GeneID" id="19895106"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01409"/>
    <dbReference type="eggNOG" id="ENOG502S9TX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1845945_0_0_1"/>
    <dbReference type="OMA" id="VGFQRFV"/>
    <dbReference type="OrthoDB" id="48036at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052436">
        <property type="entry name" value="LTO1_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532">
        <property type="entry name" value="GEO13458P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532:SF1">
        <property type="entry name" value="ORAL CANCER OVEREXPRESSED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="2">
        <location>
            <begin position="19"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="139" mass="16384" checksum="976596C1EF149D6D" modified="2013-05-29" version="1">MQINLDSLLWIENQFYHDGYQQGFRDGAVRARIEGRIEGIEKGYNTMFHIGRIYGRCDIWKWTICNQPRIIQQLLQLEQCLNKLISIQTSSPTLFRSLWNKSKAKFKTIAHLVNEQSLIETSDTEDMENTPFINDHTYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSS0</accession>
    <name>M7NSS0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cysteine-rich PDZ-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cysteine-rich interactor of PDZ three</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00215</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRIPT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872083.1">
        <property type="nucleotide sequence ID" value="XM_007873892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSS0"/>
    <dbReference type="STRING" id="1069680.M7NSS0"/>
    <dbReference type="GeneID" id="19893913"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00215"/>
    <dbReference type="eggNOG" id="KOG3476">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133934_0_0_1"/>
    <dbReference type="OMA" id="KITQGHS"/>
    <dbReference type="OrthoDB" id="147332at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019367">
        <property type="entry name" value="PDZ-binding_CRIPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805:SF1">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10235">
        <property type="entry name" value="Cript"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="105" mass="11594" checksum="32F75D8B7016C5B6" modified="2013-05-29" version="1">MVCSNCEKKGISLATPSIKKKSDIYMGSEMSKIVSSSERKIGENKLLSKSAKKRYDPYGVGCTICKQRTHHLGAKYCPSCAYKQGRCSICGKKILDTSAYKQSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSW2</accession>
    <name>M7NSW2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDB1- and CUL4-associated factor 12 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_00270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872143.1">
        <property type="nucleotide sequence ID" value="XM_007873952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSW2"/>
    <dbReference type="STRING" id="1069680.M7NSW2"/>
    <dbReference type="GeneID" id="19893968"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00270"/>
    <dbReference type="eggNOG" id="KOG4155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_11_1"/>
    <dbReference type="OMA" id="LDSSMCL"/>
    <dbReference type="OrthoDB" id="10251741at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056151">
        <property type="entry name" value="Beta-prop_DCAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051510">
        <property type="entry name" value="SKI8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090:SF1">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23760">
        <property type="entry name" value="Beta-prop_DCAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="188"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="DDB1- and CUL4-associated factor 12 beta-propeller" evidence="4">
        <location>
            <begin position="190"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="230"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR11848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="311" mass="34145" checksum="D4064CDD1302BAB5" modified="2013-05-29" version="1">MTIQYLISHIEENAHIADIYALAVTSELALTISGDSYLKIWDVDSHYHPLIHTFNPSHKIGGHSVTISKSGNAFIAASSGFLGDIIIWDLKEFKEITRLGESFNETKLGEAWTVALSPNGKILATTSYKGSLNLLDISSRENILQLETRGNFGICIDYSKNGKYIATGHEKGGLYVFSVEKGKLLHSLHGHTSTIRSVSFSPCSTFLAAAGDSKVIALYDVQSGEQVANLTGHKAWIFSLDWNITGEYLVSGAIDGTTKVWEIEKKECVGTQNHSQCAIWCVKWIIKRTGEGFISVGADKAIRWYRVAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSY8</accession>
    <name>M7NSY8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01493</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873433.1">
        <property type="nucleotide sequence ID" value="XM_007875242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSY8"/>
    <dbReference type="STRING" id="1069680.M7NSY8"/>
    <dbReference type="GeneID" id="19895189"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01493"/>
    <dbReference type="eggNOG" id="KOG4344">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010106_0_0_1"/>
    <dbReference type="OMA" id="RTNQFEV"/>
    <dbReference type="OrthoDB" id="66546at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22572">
        <property type="entry name" value="GCP5_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059169">
        <property type="entry name" value="GCP5_N_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF33">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="7">
        <location>
            <begin position="238"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="6">
        <location>
            <begin position="575"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="890" mass="104884" checksum="5F1DC770CB43915D" modified="2013-05-29" version="1">MKIRQEILELIEKLIENITGIKNENKLFYELRDKILNMIKDSSFIAINRFETKRSCYGLVEKFDILSEEYNSSMLEILFNELFMDKKNDPMIDIVALILSLSDNPCRKKRIFYEESVGNHIYEDCIDEVNDSPFIGEHWEEFNIYDDEKEEEEEEEEEEDKDDITLKSFMQKKDTVYTENVTKVPLSISITMNMQEFNFIEASQYWRTISCQNDVKRIVYKLNYNSDVSTILHETNVVREVIFMLQGNESILFLGNNDNIKINENFDISRVSHPIFISFMEWFLKKGKILNKIRNFISNSCFKSYLEDVFISSVEDLLRSLDSILAYCQSIAGNLGKKRTLTLLYLQNILDKILDPYIVLSDIISEIDDTAFETNISDFLNKLFDKANFYSICDQQTFLLITIIRSALLEAYLKPLDSWFSCGELPDIQGFFIIKSTLRPNDLLWLSEYQLNLANDGKLLIPDVLKKISQKSLLIGKLKRLLVSIFSKSGILFSDIDRDIFKQLNSDYETRLKLFSAKMNNVFDSNLFYEKSEILGESSEYDYLLNIFNWVDKNYYTTMKNFHHALFYNADFEKHLNAIFNIYCMYNNSSIINFINFVFEEMDRRKTWCDRFILQDMIQISLKHSSIDMNLINIRMKPISKDNNLSNNFYIDYKLPLSLTSIISLSSQSAYYKIFDFMFQLLKSRHDIKKYIFLFSNKLSLEKSSILIYRNLSQIKLYFNWLINVLISYFFDIVIKTQIENLEKNIKNALDLDEIINAHNTFINSVLTYCFLNLRFKRIHDSIMEIFVYVKSVSDLIISFQEKDSKKSLHMYFISDDDISNLEIDNKNLASGGLKNEEILLKNLIDIQKKTYSILKFIISELQELPQELTSTYIEILMENIEYAVLDIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSY9</accession>
    <name>M7NSY9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA wybutosine-synthesizing protein 3</fullName>
            <ecNumber evidence="3">2.1.1.282</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_01112</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36635"/>
            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.1.1.282"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TYW3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.282" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873027.1">
        <property type="nucleotide sequence ID" value="XM_007874836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSY9"/>
    <dbReference type="STRING" id="1069680.M7NSY9"/>
    <dbReference type="GeneID" id="19894809"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01112"/>
    <dbReference type="eggNOG" id="KOG1228">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047426_0_0_1"/>
    <dbReference type="OMA" id="TWLYVSH"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1960.10:FF:000003">
        <property type="entry name" value="tRNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1960.10">
        <property type="entry name" value="tRNA wybutosine-synthesizing-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003827">
        <property type="entry name" value="tRNA_yW-synthesising"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036602">
        <property type="entry name" value="tRNA_yW-synthesising-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48418">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48418:SF1">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02676">
        <property type="entry name" value="TYW3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111278">
        <property type="entry name" value="SSo0622-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA wybutosine-synthesizing protein" evidence="12">
        <location>
            <begin position="7"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00069229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR10397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="242" mass="27589" checksum="BB81F08C87A3ED5A" modified="2013-05-29" version="1">MRSEFQKKKANILNKLNAEGLDSSPKGFPDEPIVSLLDLINHHPHLVTTSSCSGRIAIYVESEIANNIGGKGLGGKWLMVQHEPWDDYLENLDILAKICGKYPVKTIDFNDSKKGPLIHFKFEPMILHIMSETISTARAFLISALSSSFRESGLILSKNNIIIAIRSSIGFSCPIGYLKKEQDVEFVQLLVDEKYLYLLIDMANKRFKENERRRDMLYRSISGWIMKESEMSMENKNELSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTB7</accession>
    <name>M7NTB7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873156.1">
        <property type="nucleotide sequence ID" value="XM_007874965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTB7"/>
    <dbReference type="GeneID" id="19894933"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01236"/>
    <dbReference type="eggNOG" id="ENOG502S997">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1548265_0_0_1"/>
    <dbReference type="OrthoDB" id="2152896at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="173" mass="20097" checksum="C67BA7F7C8088329" modified="2013-05-29" version="1">MLTVKSIKSFNDSTHEDIPLHMRMRRRGSGRYQGNGLKFKPYPSPSCSLSGTELSLDKMKKDTRKVSEVILNDIKCEHCGKGYKHISCLTKHRWEHTVYFNPKLSISKHQQVQLLEAASILIQMNQSSNFKSFPFDILFKKHDNFMDTLNDSDVNLEECVPEHHMEDNVDHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NU74</accession>
    <name>M7NU74_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Mitochondrial fission 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_00978</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the FIS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872892.1">
        <property type="nucleotide sequence ID" value="XM_007874701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NU74"/>
    <dbReference type="STRING" id="1069680.M7NU74"/>
    <dbReference type="GeneID" id="19894676"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00978"/>
    <dbReference type="eggNOG" id="KOG3364">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104368_2_0_1"/>
    <dbReference type="OMA" id="QFNYAWG"/>
    <dbReference type="OrthoDB" id="421154at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12212">
        <property type="entry name" value="Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000179">
        <property type="entry name" value="Mitochondrial fission 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016543">
        <property type="entry name" value="Fis1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033745">
        <property type="entry name" value="Fis1_cytosol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028061">
        <property type="entry name" value="Fis1_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028058">
        <property type="entry name" value="Fis1_TPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247:SF0">
        <property type="entry name" value="MITOCHONDRIAL FISSION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 11 TPR REPEAT PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14853">
        <property type="entry name" value="Fis1_TPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14852">
        <property type="entry name" value="Fis1_TPR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008835">
        <property type="entry name" value="TPR_repeat_11_Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR008835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR10832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="161" mass="18883" checksum="FE90AFD33EF25E35" modified="2013-05-29" version="1">MNSRKVFRYEEHSILPNAAETESILKPHDLEVLKRQYDREWPFVSTQTKFNYAWGLVKSKIRSEQQDGVKLLFEIYRESPERRRECLYYLALGLYKLKNYAEARRYNDLLLEKEPENIQALNLQILINKSVTKEGYVGMAIAGSLLAVGGLALGVWARWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NU88</accession>
    <name>M7NU88_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PNEG_00993</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-seryl-[protein] + alpha-D-glucose 1-phosphate = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:68748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = O-phospho-L-seryl-[protein] + alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:68752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872907.1">
        <property type="nucleotide sequence ID" value="XM_007874716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NU88"/>
    <dbReference type="STRING" id="1069680.M7NU88"/>
    <dbReference type="GeneID" id="19894691"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00993"/>
    <dbReference type="eggNOG" id="KOG0625">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009330_0_1_1"/>
    <dbReference type="OMA" id="WIQDRAN"/>
    <dbReference type="OrthoDB" id="2291at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000002">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000004">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000006">
        <property type="entry name" value="Phosphoglucomutase PgmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005737">
        <property type="entry name" value="PRK07564.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573:SF2">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PHOSPHOHEXOMUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24947">
        <property type="entry name" value="PGM1_C_vert_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="13">
        <location>
            <begin position="14"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="14">
        <location>
            <begin position="185"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="15">
        <location>
            <begin position="299"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMR10847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="556" mass="62524" checksum="A6142DB5A1202271" modified="2013-05-29" version="1">MNIETVQSRPYEGQLPGTSGLRKRVTVFQQPGYTENFLEAIFSVLRPKLGEIWIIGGDGRYYSETIIQIVIQMAAAHGVSKLVIGHKGILSTPAASWMIRTYQAAAGLLLTASHNAGGPNGDFGIKLNMSNGGSAPETIIHEIYKYTKNMTRYITLNIENIDLSEIGTRIEKGLTVEIVDPVQGYVDYLMDIFDFELIRAFFRRFTKFRMLFDGLHGVTGPYAKEIFLNRLGLPPASLQNCVPLPDFGGGHPDPNLTYAKTLITRVDAEKIDVGFASDGDGDRNMVYCVETLVSPCDCLALIAHHAEKIPYFKKNRIFGYARSMPTSRALDLVAEKKGLRCYEVPTGWKFFCTLFDHNKISICGEESFGIGSNHIREKDGLWGVLSWLNILAAINMEHEDQQFKGILDILDEFWEIYGRTYFSRYDYEEIDGFSAGKALNRFSEIIHDDDFIGSSPIYGYKVQDAGDFSYHDSITGETTEHQGLYINFSNRSRIVVRLSGTGSCGATIRIYIEKYEADRQKFHLKLQDVLRGLFEYSLSLLNLKEYIGTCTPTVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUA4</accession>
    <name>M7NUA4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Vacuolar protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01013</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 10">Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Vacuole membrane</location>
            <topology evidence="1 10">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the beta-catenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872927.1">
        <property type="nucleotide sequence ID" value="XM_007874736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUA4"/>
    <dbReference type="STRING" id="1069680.M7NUA4"/>
    <dbReference type="GeneID" id="19894711"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01013"/>
    <dbReference type="eggNOG" id="KOG4224">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021483_0_0_1"/>
    <dbReference type="OMA" id="VWDKPDG"/>
    <dbReference type="OrthoDB" id="7537227at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071563">
        <property type="term" value="C:Myo2p-Vac17p-Vac8p transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051656">
        <property type="term" value="P:establishment of organelle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061724">
        <property type="term" value="P:lipophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071562">
        <property type="term" value="P:nucleus-vacuole junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903044">
        <property type="term" value="P:protein localization to membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031503">
        <property type="term" value="P:protein-containing complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000131">
        <property type="entry name" value="Vacuolar protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045156">
        <property type="entry name" value="Vac8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47249">
        <property type="entry name" value="VACUOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47249:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0926">Vacuole</keyword>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="91"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="132"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="173"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="214"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="257"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="298"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="339"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR10867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="566" mass="62435" checksum="9B47F60577F73553" modified="2013-05-29" version="1">MGVFSWCFNCECFRGPSQATLYEPLLEDREREAVSDLLQYLENRSDVNFFCNEPLRALTTLVYSDNIDLQRSAALAFAEITEKDVREVSKNALEPILFLLQSPDIEIQRAASAALGNLAVNMENKALIVKMGGLEPLIRQMLSPNIEVQCNAVGCITNLATHDENKSKISSSGALGPLIRLAMSKDTRVQRNATGALLNMTHSDENRQQLVNAGAIPTLVTLLTSTDIDVQYYCTTALSNIAVDASNRKRLSQTEPQLVEYLVTLMDSSSPKVQCQAALALRNLASDEKYQVEIVQANGLPPLLRLLQSSFFPHVLSSVACIRNISIHPSNESPIIESLFLDPLVRLLSTNTNEEIQCHAISTLRNLAASSEKNKYAIVEAGAVQKCKQLILNVPINIQSEMTACIAVLALSDNLKGHLLSLGLCDVLIILTNSPSIEVQGNSAAALGNLSSKSKNYSHQKENMISTINDYSPFVNAWNEPGDGIHGYLCRFLCSQDITFQHIAVWTLLQLLESENKKLIDLIQNSSQITSLIEDISIREIQEEEGEVTILAKRAVEMLRNLKTYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUF8</accession>
    <name>M7NUF8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosomal protein L38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01082</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872994.1">
        <property type="nucleotide sequence ID" value="XM_007874803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUF8"/>
    <dbReference type="STRING" id="1069680.M7NUF8"/>
    <dbReference type="GeneID" id="19894779"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01082"/>
    <dbReference type="eggNOG" id="KOG3499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152057_1_0_1"/>
    <dbReference type="OMA" id="RCHRFIY"/>
    <dbReference type="OrthoDB" id="10250488at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022618">
        <property type="term" value="P:protein-RNA complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.90:FF:000001">
        <property type="entry name" value="60S ribosomal protein L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002675">
        <property type="entry name" value="Ribosomal_eL38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038464">
        <property type="entry name" value="Ribosomal_eL38_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01781">
        <property type="entry name" value="Ribosomal_L38e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR10937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="67" mass="7954" checksum="6F3C9FBFD897B3EC" modified="2013-05-29" version="1">MPKQIQDIKLFLEVSRRKDARSTRIVKDKKKVKFKIRCSRYLYTLVVNDPEKAEKLKQSLPPNLPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUU0</accession>
    <name>M7NUU0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spindle assembly checkpoint component MAD1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00669</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872569.1">
        <property type="nucleotide sequence ID" value="XM_007874378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUU0"/>
    <dbReference type="STRING" id="1069680.M7NUU0"/>
    <dbReference type="GeneID" id="19894367"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00669"/>
    <dbReference type="eggNOG" id="KOG4593">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010064_1_0_1"/>
    <dbReference type="OMA" id="YKLDFMP"/>
    <dbReference type="OrthoDB" id="331602at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008672">
        <property type="entry name" value="Mad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23168:SF0">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23168">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1 MITOTIC ARREST DEFICIENT-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05557">
        <property type="entry name" value="MAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75704">
        <property type="entry name" value="Mitotic arrest deficient-like 1, Mad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="34"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="151"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="314"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="414"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="694" mass="82181" checksum="7003A82311806217" modified="2013-05-29" version="1">MDIQETIRLRRLSDVRSAICGTSPLPNSPSMDKYDQLKIQFQSLKYDYSNAKNKWDMEKTNMEKRIHEIEQNSEEKEKKINELEKDKRFLYEKHKLQSEDMLKLKEEYSAQKQEYEWKIRELQRINSIDKENSTDRKNEEKSMFNFLHRKIETLELKNTGLEKVVEGLKDELRSKNTLINQKQQSLLEANELIDNLQKKKRSLEVETNDSTDIKILNRELFEQLSYIKSLEKKNFQQSKELKQLRESHKSIQILQEEKKDLEFQLKLMDDLRQRLGESEIERAILKREKAAWVAYLNDDDQRDFDSPKALSLTLAQQRIENAALTEKYSILEMELKEKDILHQSTCFELKKLSNRIVELEEKLNYELRNKLRLERQEVLSQKEVELLQEQLNSYNSEEMIFMHNNYDEQKTKRIKNLEMILDDYKIEIMKISEELQEAKNQTMSKSTEILKREREEIFNRHEREGDLLRRNKTLSEELLSVNKEHTLLKKELESLRQQLSYMESTSKNNGYNSQTRILQLRDNPLSALENLRQSTLDCLKNENAALLRQIEKNGEQFGDVVPIESLESLKLENLRLEGVIADKDKRIQRLKEIFAEKSSEFREAVYFLLGYKIDFLPSGKVRVTSMYSQKGDHSFVFNGKSSSMHLVKGDEFTGSIENLVKFWCEERKTIPGMLSALTLELFEQSTTGQSKGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUW6</accession>
    <name>M7NUW6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="10">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Exo-1,3-beta-glucanase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PNEG_01047</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="10"/>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10901.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613310.1">
        <property type="nucleotide sequence ID" value="XM_019757731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUW6"/>
    <dbReference type="STRING" id="1069680.M7NUW6"/>
    <dbReference type="GeneID" id="19894745"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01047"/>
    <dbReference type="eggNOG" id="ENOG502QQE6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028820_2_1_1"/>
    <dbReference type="OrthoDB" id="1293114at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF26">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00587">
        <property type="entry name" value="GLYCOSYL_HYDROL_F17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006963416" description="glucan 1,3-beta-glucosidase" evidence="15">
        <location>
            <begin position="21"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="322"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMR10901.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="437" mass="49101" checksum="C9CF3E1BE3657FFE" modified="2016-03-16" version="2">MNFLLSFWILIIAFIWRVISRGDLGFSISTRKLDGNCKSTKDYLEDISLISSYSKFIRLFSISDCNCMKNIMPAIISENMKIILGIWPGGVDTVQFRDQLSLLKEIPQEHVPYIYAISVGSEVLYRKDYSDEILLDQIITVRKLLNEMNFQSIKLGTADTWNVYADGTANRIIGALDIAFVNSFPYWQGYAIEHSVYSFFADISNTINVIRSMNYNIEVWIGETGWPTDGLTYGAAVPSVENAAYFWANVICTSLFNGLNVVAFELMDEPWKGNAIGLSGQSSNVEKFWGVFTIDKRQKYSLECPKESEKVISSINSKINNLSDSGNTNSDGSKVDSDNTDNDGSKTDFGNADNDGSKTDFGNADNDGSKTDSCNTDNDGSKVDSDNTDNDSFDEIFHDDDFLTDIKEPNKSFRVSFCLKNTFYLSFTAILFLLFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVE4</accession>
    <name>M7NVE4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_00708</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872608.1">
        <property type="nucleotide sequence ID" value="XM_007874417.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NVE4"/>
    <dbReference type="GeneID" id="19894406"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00708"/>
    <dbReference type="eggNOG" id="KOG0160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000192_9_0_1"/>
    <dbReference type="OMA" id="EIMFDDR"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15480">
        <property type="entry name" value="fMyo2p_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01380">
        <property type="entry name" value="MYSc_Myo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046943">
        <property type="entry name" value="Fungal_Myo2/2A_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036103">
        <property type="entry name" value="MYSc_Myo5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="12">
        <location>
            <begin position="1"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="11">
        <location>
            <begin position="1083"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="8">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="937"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="790"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="14"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR11111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1421" mass="165633" checksum="AB2A917C5A635961" modified="2013-05-29" version="1">MIRDNMNQTIVVSGESGAGKTVSAKYIMRYFATVEGPEKPLKRKLKNIKSGMSETEERILATNPVIEAFGNAKTIRNDNSSRFGKYIEINFDGDTEIVGARIRTYLLERSRIVFQPKNERNYHIFYQLCFGATENEKKEFDLKHPNDFNYLNQGESSTIPGISDLNNFIMTRNALKTMGISDEVQNSIFKVLAALLHLGNVKIQALRNNALLSPSDATLGFVCKLLGIDNVQFAKWIIKKQINTRSEKIITDLNLKQAIVVRDSISKFLYSSLFDWLISSINCTLKTKDEINIKTFIGVLDIYGFEHFDINSFEQFCINYANEKLQQEFTQHVFKLEQEEYMREEINWTFIDFSDNQPCIDLIESRLGILSLLDEESRLPAGSDESFVTKLVKNFSIPTYQNYFRKARFGMSSFTICHYALEVTYQSDGFIEKNKDTISDDLLNLLNSTTNNFVKEIILSSLAFQEKNQYESQNNTTRPINALSKKPTLGTIFKSSLIGLMDTINSTNVHYIRCIKPNDEKVSWKFEPKLVLSQLRACGVLETIRISSVGFPGRWTFQEFVSRYYILVHSSSWNNEVKRLSIEILEKTVNDTNKYQIGLTKIFFRAGMLAYFEHLRLNRLNECAILIQKNMLCYIYHKRYIRIRNSIILLQKYVRGFSIRKKTYEMKCNLAALKLQTAWRRYYSQKLYRKIRDAIILLQSIVRCYLIKKKILALKKEKTATKIQSLWKRYIARKKYKIQCKQIIYIQSCWRRKKAKDELKRLRIEAKSLSHFKEVSYKLENKVIELTHNLSKKHQENKLLLAQIEDLENLNNIWKTKSKKWEEERNNLENNLNNANKALERAFDLEKEIHVLKKQLNISKDNLKKLNEESNTLRESLFNKSAELESALSQKAEYEDARSNLVIEIEHLKDEVHRLSMGKNVPLGFKPNGSTRFINNTKPFSTSSPSKLHTKRQNISSSSNKENNYFEGKLLYEQKIDHKQRPASILFPLSPPKKQNILNNEISKTSYASVKDINHEFVYIVKNNDLLSDEIMVEVIKNLKIPQSSQQSSLSRKEILFPAYLINFVTFKMWKYGLIKESEHFLTNVMQTIQQAVIEYDEKDVIDFDMFWLSNVHEILSFVSIAESDILHGIAVEITDTECEEYNRLMLLVKHDLENLEFNIYHTWMKEVKKRLHKMIIPAIIESQSLPGFITTDGNKFFNKLLQGANNPQFTMDDLLSLFNKVYRATKSYYLEYSIHQQAINELLRLVGVTAFNDLLMRRNFLSWKRGLQIHYNTCRIEEWCKNHDLPEGILQLEHLMQVTKLLQLKKSTLEDIAIIFDVCWILTPVQIQKLINQYSVADYEHPISSEILKVIANKVVEDQHSNTLFLEAISLDESSIYEIPEVRELSYPQVYIPSWLNVPNIQKLAELSTCDIDTTIFSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVG3</accession>
    <name>M7NVG3_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872164.1">
        <property type="nucleotide sequence ID" value="XM_007873973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVG3"/>
    <dbReference type="GeneID" id="19893990"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00292"/>
    <dbReference type="HOGENOM" id="CLU_997914_0_0_1"/>
    <dbReference type="OrthoDB" id="5366636at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="279" mass="32399" checksum="7822CEE44DB4403C" modified="2013-05-29" version="1">MLNKPVFIDFSIKNDKNLKKNFELLNNVNSKLPNCYNEDELSSDYISLQCTSSCQALPSSPSCDIKIRLAELTTYIPSRKYKLFRKTFRLIRQNIISTCKNYISHFYYYVLEFIQQTLSFCFVFKRNQDLEESESYKRFKEEECYRRAFLQEILILTFFKQFTVKQEQIKNDEFNLSNIIKNDGSFVIKPSTSTCPITPQLQSPSSTAASVSQTSTDYTLLASELFPPFYDINQLSPGDFQSSPDKSSIMYTGDEKLTPNISLSPVFYQREQRMGIGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVK0</accession>
    <name>M7NVK0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc finger ZPR1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00765</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a protein folding chaperone for elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZPR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872667.1">
        <property type="nucleotide sequence ID" value="XM_007874476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVK0"/>
    <dbReference type="STRING" id="1069680.M7NVK0"/>
    <dbReference type="GeneID" id="19894463"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00765"/>
    <dbReference type="eggNOG" id="KOG2703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024138_5_0_1"/>
    <dbReference type="OMA" id="FREVVIM"/>
    <dbReference type="OrthoDB" id="308464at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000002">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000003">
        <property type="entry name" value="Zinc finger protein zpr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="entry name" value="ZPR1, A/B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.420">
        <property type="entry name" value="ZPR1, zinc finger domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004457">
        <property type="entry name" value="Znf_ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040141">
        <property type="entry name" value="ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056180">
        <property type="entry name" value="ZPR1_jr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042452">
        <property type="entry name" value="ZPR1_Znf1/2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00310">
        <property type="entry name" value="ZPR1_znf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22794">
        <property type="entry name" value="jr-ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03367">
        <property type="entry name" value="Zn_ribbon_ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00709">
        <property type="entry name" value="Zpr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="9">
        <location>
            <begin position="43"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="9">
        <location>
            <begin position="248"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="446" mass="51174" checksum="E3E92DC4BE06AC66" modified="2013-05-29" version="1">MGIDYKNKDSSVFKEIGAHVTNVDLDFSEESEKKDPTVEEIESLCVQCEEQGTTKLLLTIIPFFREIILISFECPHCGFKNSEIQSAGSIQEKGSVHTFVVESKEDLNRNIIKSETSSILLVELDLEIPPGKGRISNIEGFLKNVYEDLSLNQPLRKYQDPDLYEKIDQFMIRIHNLLDGLHFPFKIQLDDPAGNSWIEIEPGDPQYKWQKVDYERTYEQNVRLGLYNSEEVQNEEDFQKNEVHKFSTACPNCIKPCDTNMKLVDIPYFKEVIIMSTVCDSCGYRSNEVKTGGEIPENGKKITLKVENIDDLSRDILKSETCAITIPELDLDLHPGTLGGRFTTLEGLLAQIYDELYGRIYSKTNDSMEPEKRERWDIFLERLQDARNGKIKFTIILDDPVAGSYLQNLYAPDPDPNMTIEEYERTYEQNEDLGLNDMILNPETSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVN0</accession>
    <name>M7NVN0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GPI-anchored wall transfer protein</fullName>
            <ecNumber evidence="8">2.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00788</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">A acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PIGW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.-.-" evidence="8"/>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872692.1">
        <property type="nucleotide sequence ID" value="XM_007874501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVN0"/>
    <dbReference type="STRING" id="1069680.M7NVN0"/>
    <dbReference type="GeneID" id="19894486"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00788"/>
    <dbReference type="eggNOG" id="KOG0411">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020802_2_2_1"/>
    <dbReference type="OMA" id="GLYVMQP"/>
    <dbReference type="OrthoDB" id="15270at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032216">
        <property type="term" value="F:glucosaminyl-phosphatidylinositol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009447">
        <property type="entry name" value="PIGW/GWT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06423">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017321">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 8" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU280819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="479" mass="55120" checksum="9BD8BB6076E7E05B" modified="2013-05-29" version="1">MKSYFIFQKDMKSSYKLQKESFMSGHTGQSMTEIFLHMSIIVFMHVFSAALRSRGTNETYGISTFLIEFGIYYMIPLLFVTIFSSHLFFLALILLIPIPFLWRCPKAFKREENLTKKEKRRPKNPLNKNNIVNNGELKSYITIHRAAVMLITCLSILAVDFRIFPRRFAKVETWGISLMDLGVGFFVFSSGVVAIKSIKKNYSKETVSFFKKLILCFKQSYMFFVIGFIRILITKATNYPEHVTEYGVHWNFFFTLGFLSLSLSYLVIIALLSICNELLTRTQHILTYVLNAPRTNLISANKEGLFSFIGYLTIYLSGIHIGEHIFYRCLASRKDKSIIIYQYKTMLKMFLYSIFYFIVYFYFLFFGKYPMSRRLVNLPYVSLVSACGCGAIGCNMLIEFIFYGLSAEYTDTVPLLLHSVNKHGLIVFLAANIITGLVNSLINTLEVSNIVGFLIMVVYGIIISGLALIAEFKNWPSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWC1</accession>
    <name>M7NWC1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872337.1">
        <property type="nucleotide sequence ID" value="XM_007874146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWC1"/>
    <dbReference type="STRING" id="1069680.M7NWC1"/>
    <dbReference type="GeneID" id="19894154"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00456"/>
    <dbReference type="eggNOG" id="KOG0417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_13_2_1"/>
    <dbReference type="OMA" id="ANFKHFF"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120113">
        <property type="term" value="P:cytoplasm to vacuole targeting by the NVT pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23813">
        <property type="entry name" value="UBCc_UBE2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000073">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="2"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="151" mass="17347" checksum="73EFA0929DF41728" modified="2013-05-29" version="1">MSLPKRILKETERLIADPPPGIVAEPCQENLRYFKIKIQGPEQSAYENGIFCLELFLPEEYPMVAPKVRFLTKIYHPNIDRLGRICMDILKNAWSPALQIRTVLLSIQALLSTPNPDDPLDQSIGQEFLCSRETFDATAKEWTRLYAKIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWG2</accession>
    <name>M7NWG2_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871932.1">
        <property type="nucleotide sequence ID" value="XM_007873741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWG2"/>
    <dbReference type="GeneID" id="19893773"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00075"/>
    <dbReference type="HOGENOM" id="CLU_652310_0_0_1"/>
    <dbReference type="OrthoDB" id="5352686at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="421" mass="49872" checksum="A773D1EB6EC696D1" modified="2013-05-29" version="1">MDSLDKNLILFIDSCFEEELYQSGLEILDVVFIPNNENYGPMPFLPERYLLILINLIIQRDNTNQISQKAAQLLYRIVYSKKFSKNELYDQWSWMFCHQVRARKFRKLIDTTNIDDLNLQSNLQLNSIESIFSKFSNVWRLIQYCFEEPSTTLYILLNCIVSILELDYQEYSKESEKELEKMLFISSLKNNDREKPNIKQVLAAIFANIDLENYEYPLSFSSIMETSIKGNVIKSIESMMLRKRLLYLTYNVIYSLPKNINKFDFENELSIYLKKLEINKFIFYLSNVIPSPLKSNLCHMLLVKYSVHSKLSRHFLELSIDMLKLWPSIASHVKLGLSEKAKYSFLLQMLLKNIFNDILLKKITQEEQQAMYLAKMKRIAGFNDEFEKIKQKNKITSKYLHIKDVFEQSEYIISFILKQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWH0</accession>
    <name>M7NWH0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_00509</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872397.1">
        <property type="nucleotide sequence ID" value="XM_007874206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWH0"/>
    <dbReference type="STRING" id="1069680.M7NWH0"/>
    <dbReference type="GeneID" id="19894207"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00509"/>
    <dbReference type="eggNOG" id="KOG4709">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2110019_0_0_1"/>
    <dbReference type="OrthoDB" id="551633at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019186">
        <property type="entry name" value="Nucleolar_protein_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09805">
        <property type="entry name" value="Nop25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR11496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="14048" checksum="9EC43CD4A3D24BF8" modified="2013-05-29" version="1">MKKKKRKIEIIFDVQARWEYLTGFHKRKLERKKKVEEFMKKQEKNKRLRINKNVKEKKNIGIQKYIKSASLITQENAIQNLQDFNVRDENKNINIWQNKYDDQNYTTVTITEDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWW6</accession>
    <name>M7NWW6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_00189</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 13">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872052.1">
        <property type="nucleotide sequence ID" value="XM_007873861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWW6"/>
    <dbReference type="STRING" id="1069680.M7NWW6"/>
    <dbReference type="GeneID" id="19893887"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00189"/>
    <dbReference type="eggNOG" id="KOG2691">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093932_0_1_1"/>
    <dbReference type="OMA" id="DTSMVLF"/>
    <dbReference type="OrthoDB" id="282270at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001193">
        <property type="term" value="P:maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10508">
        <property type="entry name" value="Zn-ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034012">
        <property type="entry name" value="Zn_ribbon_RPB9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="14">
        <location>
            <begin position="71"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="11">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR11757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="110" mass="12551" checksum="26F02B295B7AD732" modified="2013-05-29" version="1">MATFHYCIECNNMLYPKEEKSQKRLLYACRNCDYSEVAKNLCIFRNELRSSLVETVGITADLGSDPTLPRSNKECPSCHGRESVFFHLQGKSAETKMSLHYVCVNCGKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NX99</accession>
    <name>M7NX99_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mediator of RNA polymerase II transcription subunit 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00208</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872076.1">
        <property type="nucleotide sequence ID" value="XM_007873885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NX99"/>
    <dbReference type="STRING" id="1069680.M7NX99"/>
    <dbReference type="GeneID" id="19893906"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00208"/>
    <dbReference type="eggNOG" id="ENOG502SD63">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1907564_0_0_1"/>
    <dbReference type="OrthoDB" id="203279at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.160">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009332">
        <property type="entry name" value="Med22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06179">
        <property type="entry name" value="Med22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR11781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="15270" checksum="0EE78F8D326DC23C" modified="2013-05-29" version="1">MNLSEDVDLLAVRTTELIKQIDEASFTLLSRFCQIIEVVDNDAKDQCTVASESYQIETHAASMIRSAEELLLISRLIKEAWMLWETNAWDPIPEQMKNISPLSLDQILALLNQYKYNQSSENTETEQQTQETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7P2D4</accession>
    <name>M7P2D4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent helicase IRC3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_03487</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875577.1">
        <property type="nucleotide sequence ID" value="XM_007877386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P2D4"/>
    <dbReference type="STRING" id="1069680.M7P2D4"/>
    <dbReference type="GeneID" id="19897174"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03487"/>
    <dbReference type="eggNOG" id="ENOG502QT4U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014765_0_0_1"/>
    <dbReference type="OMA" id="HVIDMVA"/>
    <dbReference type="OrthoDB" id="16911at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036121">
        <property type="term" value="F:double-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061749">
        <property type="term" value="F:forked DNA-dependent helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032042">
        <property type="term" value="P:mitochondrial DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18799">
        <property type="entry name" value="SF2_C_EcoAI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050742">
        <property type="entry name" value="Helicase_Restrict-Modif_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396:SF1">
        <property type="entry name" value="ATP-DEPENDENT HELICASE IRC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396">
        <property type="entry name" value="TYPE I RESTRICTION ENZYME ECOKI R PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="59"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="276"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="614" mass="70789" checksum="0831F24746015AC5" modified="2013-05-29" version="1">MKYCQLNNRILRLFLTLSQSSTYLHILQSQRYFGPYRFSSVRWNHLRPYQEACIQACLKSILEGKRRLGISLATGSGKTLIFSSLIERVEPIDPNATQTLIIAHRRELVEQAFEQCRFLYPEKTIDIEMANMHASGLAEITIASVCTLMSHERLKKFDPSRFKLILIDEVHHAAAASYIRILKHFSALNSDSKIIVIGVSATIFRLDGLKLGVAIDHIVYHRDLVDLINEKWLSNVSFTMVNSHIDLSKIKDNQFGDFERKALSSTVNTRPTNDICVRTWMKKASFRKSTLVFCISTAHCIDMANTFRSYGIDARIVTWKTPKSERYKLIEDFQKQEYPVLINCGILTEGTDIPNIDCILLARPTKSHNLFIQMIGRGMRLFPGKEDCHVIDMVGNISNGIVTVPTLFGLDPNEISHEISLNELKRIRNDKKEKRCQSSKNSQKYGISYVSSNIEQKEWNFTYDFIKQFQADLDVRRFSNFSWVRINSDKYILSIPLYGFIKVDKENDLYHASETLRIINSAKKSNAFYKKPRLIFSNVVSLKHAISAVDTYVKNKYPQRLLLKNASWRRSPATSSQIEFLRKRYPLITQNINNISKGYAWDLITRLKYGSKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7P344</accession>
    <name>M7P344_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_03417</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875503.1">
        <property type="nucleotide sequence ID" value="XM_007877312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P344"/>
    <dbReference type="STRING" id="1069680.M7P344"/>
    <dbReference type="GeneID" id="19897104"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03417"/>
    <dbReference type="eggNOG" id="KOG0048">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_931032_0_0_1"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="1">
        <location>
            <begin position="59"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="59"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="2">
        <location>
            <begin position="62"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="170"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="1">
        <location>
            <begin position="170"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="299" mass="35449" checksum="938956704910DA3B" modified="2013-05-29" version="1">MKFWTPPQVSKLQDSLQVYRLNKGLSGFISRNDSIWSEISSRIGKTAAQCYLKWKRSLNREIIKGPWTSSEKEIIEEAHKKYGSHWKKISMLVPGRTPEQIEIYFRENRRNHFKSNLRYSPYILDNIDHALSTGLYYMENGKISWTKLSKDRFPNIKPIQLRKAWLRNNTIGFKRRLWTPEDIERLVKAVEFVRSSNLSYQIWKAVAELVPGRTPASCKTKYRYLKFQRPASKIHHWTTVQYLRLINSAVTRQFRWVDVAIDIRQPEALCRTKFHDLLLEKGTISGNLAREAWFERKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3F6</accession>
    <name>M7P3F6_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_03200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875263.1">
        <property type="nucleotide sequence ID" value="XM_007877072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P3F6"/>
    <dbReference type="GeneID" id="19896887"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03200"/>
    <dbReference type="HOGENOM" id="CLU_824180_0_0_1"/>
    <dbReference type="OrthoDB" id="5332167at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="337" mass="39659" checksum="867AC3BBBC0A9C8D" modified="2013-05-29" version="1">MSEFSKKPYSDTFNSFNDKLKLRGCKINNTDKSINDLSLKIIVLKKIVEFSDQLTVDVLKTIPWDNIGQYLWKEIIDKGYDSLKLWKIFVEVYHNSIKSPDVFNRKEVFISSFIPIFKEINCDSLYWLSTLDINSNKSLTTEDFIYISYLHNLIALNVSNTNLTNMILSHWGRAAQKGKFIQLLYIDIRNNQCSISCAIYYMAKFKSLLYFSIEDNESKTMKILYEKYPQLKPSYQLIEHISQCKTFEESYRCIFNFHSHFARHSIIYNLLVKSQNTILIQQSPPLLFYLEPLKSSFSSLNITSAKRNSKTYEKSLKEKIYKKIKSKQIENWEDIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3I2</accession>
    <name>M7P3I2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PNEG_03232</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875298.1">
        <property type="nucleotide sequence ID" value="XM_007877107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P3I2"/>
    <dbReference type="STRING" id="1069680.M7P3I2"/>
    <dbReference type="GeneID" id="19896919"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03232"/>
    <dbReference type="eggNOG" id="KOG1748">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_0_3_1"/>
    <dbReference type="OMA" id="RFKTPRD"/>
    <dbReference type="OrthoDB" id="448946at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099128">
        <property type="term" value="C:mitochondrial [2Fe-2S] assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000035">
        <property type="term" value="F:acyl binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000003">
        <property type="entry name" value="Acyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002148">
        <property type="entry name" value="PRK00982.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002150">
        <property type="entry name" value="PRK00982.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863:SF28">
        <property type="entry name" value="ACYL CARRIER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Carrier" evidence="15">
        <location>
            <begin position="44"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMR08395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="123" mass="13906" checksum="6BA4D11803BCA32F" modified="2013-05-29" version="1">MLFKSISTIRPFSWNFLVQNRVNTNKMLKSVTTRFYSQARLSKEEIESRIIDIVKGFDKITDPSKITPTSSFSADLGLDSLDTVEVVMAIEEAFNIEIPDKEADEIRTIGEAITYISNHPDAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7P4P6</accession>
    <name>M7P4P6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">cis-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAPP small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875000.1">
        <property type="nucleotide sequence ID" value="XM_007876809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P4P6"/>
    <dbReference type="STRING" id="1069680.M7P4P6"/>
    <dbReference type="GeneID" id="19896642"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02955"/>
    <dbReference type="eggNOG" id="KOG3487">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085828_0_2_1"/>
    <dbReference type="OMA" id="RYMNQFI"/>
    <dbReference type="OrthoDB" id="10252102at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14825">
        <property type="entry name" value="TRAPPC2_sedlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5 6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="141" mass="16467" checksum="BF54EAA6610A1180" modified="2013-05-29" version="1">MSYFLVIVGTKDNPLFQTEFGTRKAGGDGVARFREEIRHRNQFVVHATLDLVEELQWVSSGMYMKSLDTFHQVMVSAFLTAGNIKFMLLHEIRNEDGIRNFFQEVYDLYTKCLMNPFYEVDMPITSFAFEQKVKSIAKKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7P4R8</accession>
    <name>M7P4R8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02983</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875031.1">
        <property type="nucleotide sequence ID" value="XM_007876840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P4R8"/>
    <dbReference type="STRING" id="1069680.M7P4R8"/>
    <dbReference type="GeneID" id="19896670"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02983"/>
    <dbReference type="eggNOG" id="ENOG502QPQM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PHIWISI"/>
    <dbReference type="OrthoDB" id="5784at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006676">
        <property type="term" value="P:mannosyl diphosphorylinositol ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF11">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE CATALYTIC SUBUNIT AUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="6">
        <location>
            <begin position="195"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="440" mass="50739" checksum="E43B8967F4AD54FC" modified="2013-05-29" version="1">MKRILVYPIWLTFSIFQKTENTSCIFKDMRARIKTKIKDINFNEFISRKRLFSLCKSVLLISYVEYFLSAIICISCLNILPCMAFIKIFIVLLYVLLLIFPITRVFFRPSLPIISWLILFYACRFIPSSMRPHIWISILPTLENILYGARLSSLLSNHTHFFLDILAWIPYGIVHFGAPFVTAIVIYLFSPSGTLPIFAKSFGYLNLIGVIIQLVFPCSPPWYESVYGSQLANYSMGGSAGGLARIDNFFGTKLYTSTFPASPLVFGAFPSLHSGHATLEALFLSCIFPKTTPYFVIYVLWLWWCTMYLTHHYFVDLIGGSCLAVFIFYIASYNYSSYMYSRNLFRRDYHNSIYDLPKTDPEISKLSFVRYNLLEDNKMDRISHDNHIQSFDVLSESLYTNKLSKDSLFSIWDEETVGYINTLSSFHDVGNYGDIGIVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7P584</accession>
    <name>M7P584_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endonuclease</fullName>
            <ecNumber evidence="10">3.1.30.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_02812</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.30.-" evidence="10"/>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874846.1">
        <property type="nucleotide sequence ID" value="XM_007876655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P584"/>
    <dbReference type="STRING" id="1069680.M7P584"/>
    <dbReference type="GeneID" id="19896501"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02812"/>
    <dbReference type="eggNOG" id="KOG3721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055174_0_2_1"/>
    <dbReference type="OMA" id="YVMPNQV"/>
    <dbReference type="OrthoDB" id="5418055at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004529">
        <property type="term" value="F:DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00091">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018524">
        <property type="entry name" value="DNA/RNA_endonuclease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF5">
        <property type="entry name" value="ENDONUCLEASE G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01070">
        <property type="entry name" value="NUCLEASE_NON_SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="13">
        <location>
            <begin position="71"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="12">
        <location>
            <begin position="72"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR09040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="311" mass="35155" checksum="6C3440111717EBA1" modified="2013-05-29" version="1">MVSKTYLIGMFTLGAISGGLLGFLSSSQRSPLRDSTSSNPSPREAVTQNEIINPSRIFDFCDPRPVHDLIVRKGYISCYDRQTRVPSWSATELTSESLKSGKSNRKYSKFKEDETIDPKFRAKLSDYFRSGYDRGHIIAAADVRFSQDALDETFYLTNISPQVGEGFNRNYWLYYEEFSRSLTSKFESVSIINGPLYLPKEDSDGKWRVTYEMIGNPPNVAVPTHFFSIIYAKDSSDDSVAVGSFVIPNTAIDDNTKLSEFIVPINAIERASGLDFTYKFGKKQKKLCESVECDVQQFIRDTRQSLASEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7P658</accession>
    <name>M7P658_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_02290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874284.1">
        <property type="nucleotide sequence ID" value="XM_007876093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P658"/>
    <dbReference type="STRING" id="1069680.M7P658"/>
    <dbReference type="GeneID" id="19895983"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02290"/>
    <dbReference type="eggNOG" id="KOG3089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057568_1_0_1"/>
    <dbReference type="OMA" id="DHFAQKA"/>
    <dbReference type="OrthoDB" id="1929311at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032704">
        <property type="entry name" value="Cms1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24030">
        <property type="entry name" value="PROTEIN CMSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24030:SF0">
        <property type="entry name" value="PROTEIN CMSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14617">
        <property type="entry name" value="CMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR09335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="255" mass="29796" checksum="BAA190D11C2150E9" modified="2013-05-29" version="1">MSVSEKTAKSEGENSTFECLETEEIILEKKRKKKEKRRLYRSKKRAIEEPYMPETVSFLSAAIQADYVEKKIREVYMNYSSLELEDMRMSEKYFFETCWTGGWNLEHLSKFLEIGIGYDPRYIPSPCGSPHTIILAMAALRVADITRSLRSYKTKDGDVAKLFAKHIKLKDHINYLSRTRLTIAVGTPGRILDLINCDSLKVDFLNWIILDTTYNDVKKRKFWDMPECWRAMIKLITTDPLKTMLKKGSVKIVYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6H6</accession>
    <name>M7P6H6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02067</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 19S cap proteasome complex which acts as a regulatory subunit of the 26S proteasome, involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both ends by the 19S regulatory complex (RC). The RC is composed of at least 18 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively. Component of the lid subcomplex of the 19S RC.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874048.1">
        <property type="nucleotide sequence ID" value="XM_007875857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P6H6"/>
    <dbReference type="STRING" id="1069680.M7P6H6"/>
    <dbReference type="GeneID" id="19895761"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02067"/>
    <dbReference type="eggNOG" id="KOG0687">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031814_1_1_1"/>
    <dbReference type="OMA" id="RLHCKVD"/>
    <dbReference type="OrthoDB" id="1452at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000005">
        <property type="entry name" value="26S proteasome regulatory subunit N7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049549">
        <property type="entry name" value="RPN7_PSMD6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21154">
        <property type="entry name" value="RPN7_PSMD6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="189"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00093435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00093502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="391" mass="45536" checksum="E74AE7B74F9BA3AD" modified="2013-05-29" version="1">MKEIPIAPVPDLRLADYIFVILNDKSLERKKNATELLLSAIKEGNLAPLYLYLHEHIQSFPFDTLLYNDLKAENDKELEKLDNEIKKVQEMDGEQEIADILRKKAEYFARICDKEKALESYQEAYNNTVTGFQIDILFGIMRIALFFSDTSLFIRNMDKVKNLIDNGGDWDRKNRLKTYMGLHYISIRNFKEATRLFLDSISTFTSTELMTYEDLVKYTVISASISLERVHFKQKIVDSPEVLSIIITDKSFISLKNMINSLYYCNYALFFRALAEVEENYLRVDRYLFLHADYYLREMKRKSYAQLLESYKALSISSMASAFGVSVEFIDKDLSKFIANKQLNCIIDRVNGIIETNRPDSKNAQYQLLIKQGDHLLNKLQKFQARVMAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7P7P1</accession>
    <name>M7P7P1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02054</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAND family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874036.1">
        <property type="nucleotide sequence ID" value="XM_007875845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P7P1"/>
    <dbReference type="STRING" id="1069680.M7P7P1"/>
    <dbReference type="GeneID" id="19895748"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02054"/>
    <dbReference type="eggNOG" id="KOG1824">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007157_0_0_1"/>
    <dbReference type="OMA" id="AYIPHFQ"/>
    <dbReference type="OrthoDB" id="6260732at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013932">
        <property type="entry name" value="TATA-bd_TIP120"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08623">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25782">
        <property type="entry name" value="TPR_CAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Stalled ribosome sensor GCN1-like HEAT repeats region" evidence="6">
        <location>
            <begin position="8"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="272"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="TATA-binding protein interacting (TIP20)" evidence="5">
        <location>
            <begin position="1052"/>
            <end position="1214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1243" mass="144010" checksum="3F1DCC6A869A7FFD" modified="2013-05-29" version="1">MILNSYFIYSLIEKMKSQDKDLVFMAIVDLMNEFQKSTTCQLEEDICIQVIDSLVRLLKDKNGEVQNLAIKCLTSFTKKCENNHLVIILDILCNFFESNEGILEKNMLRDISFTALRNIIIETPSPSPIAVTIVHFLFPKLLSQLITDTILENQMDIINVMIELLSKFGVEIASLSFVEQKHIQTILVHLLDSPYAVIRKCSVVALGLFSLYLSNDLFPLFMDNILKKVDTESNDRLKTLVFLFGKLSSSTFSTSASSFFSNYRFSKYLKSIIPVILKTLKKDDDEVRELALQTLEIFILHFDKETKPYISYIIEELVLLLNYDPNYTDSDINVEMESNSDEFDNSDYSNDDMSWRIRRFSCKLLNTIINTYITLFQQHYFQVAISLIQKFNEREEVVRYDVLNTFTSLIRQTSYLLFKRSENLDFGQFKENNMSNIYLELPFLFKKKISILLPEICKVLSIQLMSSSISICQAGYVLITELTKIMAKEMDSQYQYFMRPIEILLASSFYNEISSISMSSVTDLRIEALRFVKEMLSQTSYHIIQPYLHIFIKGITVSIQDKFYKISAESLCSLSFLIKLLPSNGDDFEKSFDELYFIVLEKASVANIHDDVEENAMMAMGHFLIYMNLDENKQNLVLNILTEKLNNETTQLLTIKIIRDIITFRIPKLDCKWVTKTVVLLLGFLEKNNKSLKLPCLLALSGFMKISENTLEFSVVRKLVDTIIFIIFSKDYHILSSTILLLVNLIKYIDVPFTIFEELFHHIMHLIRTPLVQNSIEIQDKVLDFMKVSIKKGSFNYLFKKLFFIDVSFNEMSFFSKIIALILENGFEFLINNFIEEVKVSEIVKKKCFLLMVLGEAGRKMNMARYINIMDVVFSQFFSSSNDLKRISAFALGNIVAGNISTYFPFFINQLQSEFSEYCLLLIALKEIIIHHDRSSNFMTYFIDVLNILFKCSISDESCRPIAVECIGRLALLKPHYFFPEFQKQVKNSSTEIQLVVISAIKFTFTSSVNEFDSFLSLIIDELLLSVENSQLIVKKLIFEVLNVAIHNKFYLVQIHMQKFLAVLYKETIIKDNLMKRVQVGPFVHIVDDSFELRKSVYEILYSICEMFFAYVEDVSGFLDIVICGLDDCHDIKIFSNLILIKLCTLAPREIQAVLDSISVKYSIILNSKLKDTAVKQEIEKNIELRQSILRSIIALSRISNKFATPKFYMFYNDLLNNLTNDEFKFVKEFEIVDCSSLNILSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7P8E9</accession>
    <name>M7P8E9_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873364.1">
        <property type="nucleotide sequence ID" value="XM_007875173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P8E9"/>
    <dbReference type="STRING" id="1069680.M7P8E9"/>
    <dbReference type="GeneID" id="19895122"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01425"/>
    <dbReference type="eggNOG" id="ENOG502QRTT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TTPDRSW"/>
    <dbReference type="OrthoDB" id="5577218at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048309">
        <property type="term" value="P:endoplasmic reticulum inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160031">
        <property type="term" value="P:endoplasmic reticulum membrane biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013635">
        <property type="entry name" value="Ice2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31726">
        <property type="entry name" value="PROTEIN ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31726:SF2">
        <property type="entry name" value="PROTEIN ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08426">
        <property type="entry name" value="ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="408" mass="45968" checksum="6EB84A06762F6DA3" modified="2013-05-29" version="1">MGFIYFCLKIFLSTISFGQLILSIPLSFDVGGRISGLAYTLSLEVLYFFICLFSILKKSPKIRPFVQIITLSQFLMVPSLMIYFLDTISEKSTPSLFIRICTRIWLAFLTRSTPIFTLLEGFTSLLVIQAVGQFVKWLVNNCSDWWMIFLLSGSGGILSASFYFLYQIYTSLIVTVQNATLIGILLTCAIFVCSFSIHTGRGNVVEGSLLFAYLVYSVYMISSDLQPSGDMLKEKNINRNGSVLPFPPIIMESYTTIVSSIAFKIPKALWRTVFFLKAITSTITPSIIISLVYRLIVLYSATFIVPAVRSVYRGVEHVPSLDNKELTSRIMNILISFSPCVLIAVYTHLLLQHFSLHGHDALIFGIQMGSVLIWRWLTAFMVVGFYAIEILLGDETTSDILISHWKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7P8G1</accession>
    <name>M7P8G1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HhH-GPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01434</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkylbase DNA glycosidase AlkA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873374.1">
        <property type="nucleotide sequence ID" value="XM_007875183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P8G1"/>
    <dbReference type="STRING" id="1069680.M7P8G1"/>
    <dbReference type="GeneID" id="19895131"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01434"/>
    <dbReference type="eggNOG" id="KOG1918">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1010556_0_0_1"/>
    <dbReference type="OMA" id="MILMFAM"/>
    <dbReference type="OrthoDB" id="415889at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032131">
        <property type="term" value="F:alkylated DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000004">
        <property type="entry name" value="DNA-3-methyladenine glycosylase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051912">
        <property type="entry name" value="Alkylbase_DNA_Glycosylase/TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003:SF5">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="4">
        <location>
            <begin position="90"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR10160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="288" mass="33315" checksum="53F667F71254B0F1" modified="2013-05-29" version="1">MKRINNKLLKVEKKHKKLDIIQWKISDCGMILNPIFSEEYSTLLSKALEHLIKANPRFQILSECFSCLPFSPEGLMENINPFQSLCIIILSQQLSKHSSASIYRRFLRLFFSNYLDTSQDDKLSLSQLSISKVFPTPQEVYDISSEDLRLIGCSSRKIEYLKLLADSFLSGKISPSFFINSSDEDIIERLIAIKGIGLWSAEMFLLFSLKRTDILSTGDLGIQRGMALMKGKNISKPNKGKWKYMSHEEMIQMAEPWRPYRSIASWFIWRITNTTFTQENHVSSLKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M7P940</accession>
    <name>M7P940_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873565.1">
        <property type="nucleotide sequence ID" value="XM_007875374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P940"/>
    <dbReference type="GeneID" id="19895303"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01608"/>
    <dbReference type="HOGENOM" id="CLU_2623032_0_0_1"/>
    <dbReference type="OrthoDB" id="5363732at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="78" mass="9335" checksum="B6D35E805E864E23" modified="2013-05-29" version="1">MQQLEFDEVLPLEKRLLVNYSEKKTSSQSTEFPVKPIIKRPEPTPLFKRLESFLPQIRELNQELIQKKQKNQLIIEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7P9A1</accession>
    <name>M7P9A1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_01146</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873060.1">
        <property type="nucleotide sequence ID" value="XM_007874869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P9A1"/>
    <dbReference type="STRING" id="1069680.M7P9A1"/>
    <dbReference type="GeneID" id="19894843"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01146"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_897476_0_0_1"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001485">
        <property type="entry name" value="Krueppel-related zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002157">
        <property type="entry name" value="Transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR10430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="310" mass="35641" checksum="DB4BD110D77AE978" modified="2013-05-29" version="1">MATIQSKQSDEKDPKKQKGLETRELEESCNKRRYPCSFEGCNKAFQQQAHLRIHLRCHSGEKPFVCEHCGKTFAQLGNLKTHQRRHTGEKPYICTYPNCEKKFAQKGNLRAHKLIHEGIRPYVCRLDNCTKTFTQLGNLKVHQNKFHNESICRLNAKLMSVQLPNPEDEQLLDYFSTLYRYSNQGIKGRGKEKIELPLKQETQSINDATDASEDFSVNSPHLSSADKMVSQTIKHENSSITDDIGVHELLQLNQEQIQQLIALNKLEKIVSDDLQDNSQNTLQELEQINVRDLLLQLGDPSNLHDMTEFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7P9I0</accession>
    <name>M7P9I0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kri1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KRI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873155.1">
        <property type="nucleotide sequence ID" value="XM_007874964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P9I0"/>
    <dbReference type="STRING" id="1069680.M7P9I0"/>
    <dbReference type="GeneID" id="19894932"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01235"/>
    <dbReference type="eggNOG" id="KOG2409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009647_3_0_1"/>
    <dbReference type="OMA" id="KIMATRH"/>
    <dbReference type="OrthoDB" id="10252032at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018034">
        <property type="entry name" value="Kri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024626">
        <property type="entry name" value="Kri1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490:SF5">
        <property type="entry name" value="PROTEIN KRI1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490">
        <property type="entry name" value="ZINC FINGER, ZZ TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05178">
        <property type="entry name" value="Kri1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12936">
        <property type="entry name" value="Kri1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kri1-like C-terminal" evidence="3">
        <location>
            <begin position="444"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="292"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="550" mass="65594" checksum="EDE4A14F2359FE0B" modified="2013-05-29" version="1">MHLLSDHDDSDDLDKIVINEAYARRYQHNKAREELHRLKDKYGSDFENTESSETEDEIGDLATPSMNAAILETILKIRNKDPDIYKSDVNFYENVEDELIIKEKSKPFRLNDYHRQQLLDSSKNGMEEEKKLDVSDPTYVEEQRMLKEEILTVFHGETHDDEFLTLRKKSLQEQEEEDKAYKDFLMEKVEDKVRKKILQQWINVSNKPLDESNEKSSKDTRDENFLFSYVLNRGWIDKNANRVASYDEVIKGLESDESFDEKVDEFEAKYNFRFEEEDSNQISSYSRDILSVRRKNEKRKHLREKKNQLKRIEKLKKEEEIFRLKNLKRKELMEKLNKIAQVTGDSTLKFEDIDIEGDFDPDKWSARMDKIFNEAYYSKKEKKPVFEDDTDIECIDSDYGESLKNYSDVEINSTNSQKNQMKSKKNISAVKLSKKEKEDRKRKLDFMLGQHYNVNIKKSGTFKYNKVDPYIFGLNHADILYANDAELNEFVSLKKLTPYRNKKLQEKDKKKYGKKKRLKEWRKKVWGEYLDNQDIVEKSNTNMFNDKKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAS5</accession>
    <name>M7PAS5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coiled-coil SMC6 And NSE5 INteracting (CANIN) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00573</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR10970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872468.1">
        <property type="nucleotide sequence ID" value="XM_007874277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PAS5"/>
    <dbReference type="STRING" id="1069680.M7PAS5"/>
    <dbReference type="GeneID" id="19894271"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00573"/>
    <dbReference type="HOGENOM" id="CLU_511014_0_0_1"/>
    <dbReference type="OMA" id="DMARTND"/>
    <dbReference type="OrthoDB" id="5350396at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="63062" checksum="594797B5CC049A7A" modified="2013-05-29" version="1">MSLNDKNFTKNKKTKNTIITDFFQLKNCSTSKLSEFPEKKDFLDNDKEISDLKNKLTIKYDFEKLNNQKNQEETLESTSSNYQFSLETLLKDQENRKKRYESFNRLEKLLNNEKTHLEDCSSHISSRIEMVIGKKKGLELQAVLDDINIFRKQFCWSFFGNDIEKIVQEDISIEDFELQMDILTFEKERFPFLLITGYFLDIVDSGKKFSMKFVQWLLDNISLEKNEMMLYGYFSILSKIYSSPQQMHVLSEFQIRRIFLLLGAVDEAINTKSSINPINIENTNYNIDRNYHSKIINLKLVLDLLRTALLHNRIKKHQSILFIFSIILKLYMDDNCLFHLGSSLYLCFLQLFNTISSTEFQTMALEMFNIAYNITKNSFMRLSILQSLPIGHVYGRILRFGLAFSMLLNIDVPPDNFPRSYIFPFSKIFDHIQMSRPFFPIDSDTDYFELCIAIYMLDYIFFQPSYQDNQEIKKICKLLKHIYEKISDCRTAFIIKTEAKAKIQKLLLRLTPHTYGDFSKMHQSTLEYHFNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAT5</accession>
    <name>M7PAT5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CAF1B/HIR1 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_00588</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR10985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872483.1">
        <property type="nucleotide sequence ID" value="XM_007874292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PAT5"/>
    <dbReference type="STRING" id="1069680.M7PAT5"/>
    <dbReference type="GeneID" id="19894286"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00588"/>
    <dbReference type="eggNOG" id="KOG1009">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010127_0_0_1"/>
    <dbReference type="OMA" id="QIYWHES"/>
    <dbReference type="OrthoDB" id="71227at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045145">
        <property type="entry name" value="PTHR15271"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271:SF4">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="10">
        <location>
            <begin position="1"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="135"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="177"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR10985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="517" mass="57662" checksum="BC0E64AADF34F526" modified="2013-05-29" version="1">MKASVIQIHWHTEAASIYSAHFEPCNKGRLATAGGDGNVRIWRVERSQVTSQLSNELNKMTHTTYSPRLIYLSTLSKHTQAVNVVRFSPRGGLLASAGDDGNVLIWVLSDGFHSSVSLGNDDSNDKEIWKIFRFCRSSGAEIYDLAWSPDAMYLLTGSMDHVARIYNVNEGQCIQQLTEHTHYIQGVAWDPLNTYLATTGSDRTVQIYRINTTSKFSVTLHASLSRMEYPTAFGMYHNEALLSFFRRLNFTPDGSLLLVPAGQYRSSSESEETLHTVYIYTRAGLNRSPIAHLSGHKRPAIIVSCSPKYYTLRNVEKNDKLTKTLPIVNIALQDDSVSNSASNCILDTFTDTSKSVFDRVPSAFSLAYRMIYAVATQDTIVLYDTQQVNPIGMLSNFHYATLTDLAWSFDGNALLITSTDGYCSIALFDENELGEEYIGPLSSSCSEHSTLLKDPLKVLIDIPNSMTNISSQPVKLQSTDKDNISSHNLEDPLSTAVSIKEKKRRIAPTPVQFFDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7PBG1</accession>
    <name>M7PBG1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DWNN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_00809</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872716.1">
        <property type="nucleotide sequence ID" value="XM_007874525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PBG1"/>
    <dbReference type="STRING" id="1069680.M7PBG1"/>
    <dbReference type="GeneID" id="19894507"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00809"/>
    <dbReference type="eggNOG" id="KOG0314">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019105_1_0_1"/>
    <dbReference type="OMA" id="CGAKDHW"/>
    <dbReference type="OrthoDB" id="106784at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16620">
        <property type="entry name" value="vRING-HC-C4C4_RBBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014891">
        <property type="entry name" value="DWNN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033489">
        <property type="entry name" value="RBBP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439:SF0">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08783">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01180">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51282">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DWNN" evidence="10">
        <location>
            <begin position="5"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="282"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="365"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="387"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR11220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="57935" checksum="8F63B9F44FB618DB" modified="2013-05-29" version="1">MSNSIYFKFKSQKEPGRISFDGTTGLSVFDVKREIILQNKLGSGTEFDLAIYNSNNEEYDDDTTIIPRSTSVTVRRLPPSKPGKGTAARYVSGNASIGSYARTDIFPKKPTELKTKPMPSLNTATPQGKEDAEDAAIQAMFAASNEQWRETQDKLATATPIFRPNNKKLIPTNVPDRPPPAGYICYRCGEKGHWIQLCPTLSDPSFDGKLRVKRTTGIPKSFLKTVEKTYNDNSGSFMVNADGEHVIAQPDNASWENYKSRTKIFTASNIYSFKPDDLTLECTLCHKLMKNPSTIPCCQEEYCEECIQTTLLEADFVCPKCGTKDILLDTIQINNDKKERIEEYINNKMRNENISVNKKSSLTTSNIDSSQVSQLNIKSKKRPFSDDGNSASQTHPKQNGQAMDKNQPLNPHSIQPDLSSQINGNFMSFFPDPFMLNPYMMSMNSIMTPSICGLPQYGNYECYPLDISKYGYFPNQQKVFSKEEDSPYTRIPLNDRNTHRQKRIRQADFRELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7PBX4</accession>
    <name>M7PBX4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="4">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate phospho-hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_00405</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>diphosphate + H2O = 2 phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872281.1">
        <property type="nucleotide sequence ID" value="XM_007874090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PBX4"/>
    <dbReference type="STRING" id="1069680.M7PBX4"/>
    <dbReference type="GeneID" id="19894103"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00405"/>
    <dbReference type="eggNOG" id="KOG1626">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040684_0_1_1"/>
    <dbReference type="OMA" id="GVWAMID"/>
    <dbReference type="OrthoDB" id="1608002at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.80.10:FF:000004">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR11380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="290" mass="33025" checksum="1D6CC9009190FE9A" modified="2013-05-29" version="1">MSNLYGKYTQRLVGTPNTPNFRVFIEENGVPISAFHDIPLYANPEKSILNMIVEVPRWTNAKMEISKEELLNPIKQDVKKGRLRYVRNCFPHHGYIWNYGAFPQTWEDPNLMHSETKAKGDNDPLDVCEIGEAVGYVGQIKQVKVLGAMALLDEGETDWKIIVIDVNDPLESRLNDVEDIEKHLPGLIRATNEWFRIYKIPDGKPENTFAFSGECKNKKYALEIIQECSESWDRLISGESDLRGINCTNTMVSHSPFYTTENIHIPPGENNPPAPKDPSIDKWFYISGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7PBY7</accession>
    <name>M7PBY7_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00419</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872296.1">
        <property type="nucleotide sequence ID" value="XM_007874105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PBY7"/>
    <dbReference type="STRING" id="1069680.M7PBY7"/>
    <dbReference type="GeneID" id="19894117"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00419"/>
    <dbReference type="eggNOG" id="KOG2363">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048451_3_0_1"/>
    <dbReference type="OMA" id="CYGPGIT"/>
    <dbReference type="OrthoDB" id="17948at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002738">
        <property type="entry name" value="RNase_P_p30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01876">
        <property type="entry name" value="RNase_P_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR11395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="261" mass="29375" checksum="115316A8E4A626FD" modified="2013-05-29" version="1">MYDLNVLWHGSGVSEIEMKKMIAFLIELGYSTIALNCMVYGKIGKKIVNPIRSNIVECERSIRILSRVTIVLEEGSQNYNLYSATDTFDILAVRPMNEKMFQHACTSMDVDIISLDMSQRLPFYIKHSTVSIAITRGIRLEICYGSSISDINCRKNLISNASALIRATRGKGIVISSEASNLMYCRSGYDVINLSTFWGLSQEKGRDAIGKEAKYVIIHGEARKNTSKGVIKLVDDKILQEKRNVKEELVHQINKKNKTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7PC87</accession>
    <name>M7PC87_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00528</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872416.1">
        <property type="nucleotide sequence ID" value="XM_007874225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PC87"/>
    <dbReference type="STRING" id="1069680.M7PC87"/>
    <dbReference type="GeneID" id="19894226"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00528"/>
    <dbReference type="eggNOG" id="KOG3769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034765_3_0_1"/>
    <dbReference type="OMA" id="KAWYLYE"/>
    <dbReference type="OrthoDB" id="67027at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19873">
        <property type="entry name" value="DSRM_MRPL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044443">
        <property type="entry name" value="Ribosomal_mL44_DSRM_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044444">
        <property type="entry name" value="Ribosomal_mL44_DSRM_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF32">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22892">
        <property type="entry name" value="DSRM_MRPL44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="9">
        <location>
            <begin position="251"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="353" mass="40043" checksum="E04AA0CD0913C737" modified="2013-05-29" version="1">MYKEILMKSKGFITIFCQLNIQRRLESTLQKKKINVNMSGNMNKKEEDIFKLMNEVSAKLFALHARLKLGPQFPNVTLVKTFLDFGVINGLGSVPNNRHLFTLGTCITEYFVSEYLMVRWPRLPYKIMKATLWGYCGTKALAKIGLEWGLETSNKEVNVIPNSSKNELDSVFFEVLSEARNGRLVFKRKGLPHGYSSSTYYEHLEKVVSRMVLSVIGGIYLHCGLTTVKKFVNDHIISRYLSISSMFSFEQPGRELSVLCSRQKLDPPVSRLIAETGRRSSAPLFVVGVYSGNDKLGEGHGSSLKEAKYRASVDALKAWYLYESKGFDFPSKTLENNKEIYTPVHIDYGEVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7PD04</accession>
    <name>M7PD04_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <ecNumber evidence="6">5.4.2.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cofactor-independent phosphoglycerate mutase homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_03169</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="6"/>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875232.1">
        <property type="nucleotide sequence ID" value="XM_007877041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PD04"/>
    <dbReference type="STRING" id="1069680.M7PD04"/>
    <dbReference type="GeneID" id="19896856"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03169"/>
    <dbReference type="eggNOG" id="KOG4513">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026099_2_0_1"/>
    <dbReference type="OMA" id="FMDGRDT"/>
    <dbReference type="OrthoDB" id="1886626at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1450.10:FF:000001">
        <property type="entry name" value="2,3-bisphosphoglycerate-independent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="entry name" value="BPG-independent phosphoglycerate mutase, domain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01307">
        <property type="entry name" value="pgm_bpd_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637:SF0">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="13">
        <location>
            <begin position="7"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="BPG-independent PGAM N-terminal" evidence="14">
        <location>
            <begin position="86"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR08329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="451" mass="51067" checksum="F8C020A85FB461F7" modified="2013-05-29" version="1">MAKPLEKVCLICIDGWGINPKKNSKEDAISAANIPIMSSLMKKYSSMELKAHGNAVGLTEGLMGNSEVGHLNIGAGRIVWQDLVRIDKTVKNKGFIQVEAIVSSMERSKAGNGRFHILGLVSDGGVHSHINHLFHLLETAKEIGLKEVYIHFFSDGRDTSPLSSIKYVEQLMNKIKDLGIGELATIVGRYYAMDRDKRWERITIALEGIIYGIGEEDSDVINVINRRYQKNETDEFLKPIIVNKKGCISDGDTLFFFNYRSDRVRQITQVLGVDSTLTSLQIPKNLSITTMTQYKVDYPFPVAFPPQKMDNVLAEWLSKKGILQSHVAETEKYAHVTFFFNGGVEKQFEGEQRDMVPSPKVSTYDKDPKMSVDGVAQKISERITENKYPFIMCNLAPPDMVGHVNFKLISFPFTINKIRQVYMMLLSKQLNILIELSELFIIHVKKKDIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7PDV6</accession>
    <name>M7PDV6_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_03122</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875181.1">
        <property type="nucleotide sequence ID" value="XM_007876990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PDV6"/>
    <dbReference type="STRING" id="1069680.M7PDV6"/>
    <dbReference type="GeneID" id="19896809"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03122"/>
    <dbReference type="eggNOG" id="KOG1728">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073626_0_2_1"/>
    <dbReference type="OMA" id="DYEKCPF"/>
    <dbReference type="OrthoDB" id="10254436at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.1000:FF:000001">
        <property type="entry name" value="40S ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_uS17_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_uS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_uS17_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006345">
        <property type="entry name" value="PRK08572.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS17 N-terminal" evidence="5">
        <location>
            <begin position="7"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="159" mass="18557" checksum="3C8B832F0A2CC502" modified="2013-05-29" version="1">MSELVLQSERGFQKQPHVFLNTKASLNKKFGKNRRWYKDVGLGFKTPKEAIKGEYIDKKCPFVGNVSIRGRILTGIVVSTKMTRTIIVRREYLHYIPKYNRYEKRHKNFAAHLSPAFRVNEGDIVTVGQCRPLSKTVRFNVLRVERHNEIDTAKQFGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7PDZ7</accession>
    <name>M7PDZ7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Pre-mRNA-splicing factor CWC2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PNEG_02867</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM CWC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874904.1">
        <property type="nucleotide sequence ID" value="XM_007876713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PDZ7"/>
    <dbReference type="STRING" id="1069680.M7PDZ7"/>
    <dbReference type="GeneID" id="19896554"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02867"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043308_1_0_1"/>
    <dbReference type="OMA" id="CNIAKDS"/>
    <dbReference type="OrthoDB" id="10251848at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12360">
        <property type="entry name" value="RRM_cwf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000249">
        <property type="entry name" value="Pre-mRNA-splicing factor CWC2, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034181">
        <property type="entry name" value="Cwc2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032297">
        <property type="entry name" value="Torus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16131">
        <property type="entry name" value="Torus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="16">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="156"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="13">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMR08689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="41772" checksum="D7B1F9D953DA78EB" modified="2013-05-29" version="1">MELASGDENTQNLSLNSKEKNVEKKKKRRPARRQVEGRERTGELMPPQTGQVFNIWYGKWAGGDKEDKYINKNKSETRCNIKRDSGYTRGDKIKGAYFCLFFARGSCSDGPDCTFLHRLPNVHDIYSPNVDCFGRDKHSDYRDDMGGVGSFMRQNHTLYCGRIHVTDDIEEIVARHFSEWGEVERIRVLNSRGVAFITYVNEANAQFAKEAMAHQSLENNEVLNVRWATQDPNPVSQARDARRIEEQAAEAIRRALPKEFIAELENYGKKIKRDDFGLDGYDAPDDIWYARGSSAVNPAGRPSHIPVEISIENTSDPSVSENAYDEETNEIFSRKTLDTLQSLNAVCTTHLSLNNSLGLVEYTSDDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7PES2</accession>
    <name>M7PES2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA mismatch repair protein S5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02742</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874770.1">
        <property type="nucleotide sequence ID" value="XM_007876579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PES2"/>
    <dbReference type="STRING" id="1069680.M7PES2"/>
    <dbReference type="GeneID" id="19896433"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02742"/>
    <dbReference type="eggNOG" id="KOG1979">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ANYHVKK"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000003">
        <property type="entry name" value="DNA mismatch repair endonuclease MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000014">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="6">
        <location>
            <begin position="230"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="683" mass="77716" checksum="EA7BD6381F486318" modified="2013-05-29" version="1">MNESTDLNLRFPKRILPLDITVVSKIAAGEIVQRPCNALKELIENCVDAGATSIDILVKGGGLKLLQVSDNGHGIMKEDLSILCERFTTSKLRTLEDLSSISTYGFRGEALASISHVSFLTVITKTTGSSCAWEANYLNGKLISPKLGEPSNPKPAAGKQGTQIVIKDLFYNIPSRLKSFCSANDEYVRILDIIYRYAIHCEKVSFSCKNYGEAIPSISISSRSTVIERIKQLYGTSVGFELLPFSLTSQDYMFQAHGFITSTSYSARKTVFLLFINHRSVDCNTLKSGLESIYSNFLPNSGHPFMYISLEIESSRVDVNIHPTKHEVHFFNEDEIIDLICDKVRLELSKTDSLKEFSMHSLKTTTYSLNSDINCNSMGGKVHDKYHVRTDSKFQTITSFLNNVNSLNSKKLKKSSSIEDFDHELLYEMNNREKVIVRLASIKELRDEVIDRRDDVLTNIFMNHIFIGVVDEEKQLAAIQCSTELYFVDYGSLCFELFYQIGLAGFANFGTIKLEPQLLLVELLEILSENLECDSMVSKKIIDVFKIIINYREMLYEYFSFGVTSDGKIYSLPLLLKGYIPNIGKLPLFIYRLCTKVNWDQEKECFCTFLKELALFYSPEPLFQKQYDIETYENEKKILARVLESVLFPAFKKRLIGTIELSRKKNVVQVATLPKLYKVFERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M7PGZ1</accession>
    <name>M7PGZ1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873885.1">
        <property type="nucleotide sequence ID" value="XM_007875694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PGZ1"/>
    <dbReference type="GeneID" id="19895603"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01909"/>
    <dbReference type="HOGENOM" id="CLU_679913_0_0_1"/>
    <dbReference type="OrthoDB" id="5410356at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="405" mass="46449" checksum="5DD43FA72FC64DDB" modified="2013-05-29" version="1">MINHSAISLDLKAHNHNIYDNFYFSELSDEDNVSSENIQESLTSLVKKLKWKIANKDRDKEKLFSDYENLQQKYNTLLLSYESLQVSSSKQLADMKAKLLSLSSEMNRNMNSLYEELEIKTLHLNEVKQKLEKFKKANRIANEHIESLQIEFNRERSRWEEEKIKLSLSLSKNSLKKNEILEEFMLLHKYFENIKLESLETKENSSVGAASSINIKNDGIIASSFDNFFPGQSLATELGLCSDKDKNSNSEAFISIDFLDINNSSVFSKTYTSDCQVDKISLPLKESILKPSSEDVIYSPTNINTSITSSTKIIEEKVSQLTLSTQTLPTKKTSMLNMIQICTNYSLNFKNPHLFESEKSKNYLLKNKKPCVSTATYFYKHQNSRISPPLPIPIRKASLIFKSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7PI38</accession>
    <name>M7PI38_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dystroglycan-type cadherin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01407</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873343.1">
        <property type="nucleotide sequence ID" value="XM_007875152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PI38"/>
    <dbReference type="STRING" id="1069680.M7PI38"/>
    <dbReference type="GeneID" id="19895104"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01407"/>
    <dbReference type="eggNOG" id="ENOG502QURR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_326279_0_0_1"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006644">
        <property type="entry name" value="Cadg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21559:SF21">
        <property type="entry name" value="DYSTROGLYCAN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21559">
        <property type="entry name" value="DYSTROGLYCAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05345">
        <property type="entry name" value="He_PIG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00736">
        <property type="entry name" value="CADG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082976" description="Dystroglycan-type cadherin-like domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="4">
        <location>
            <begin position="25"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="4">
        <location>
            <begin position="372"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="862"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR10129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="883" mass="98379" checksum="D0CA870EEE6261E0" modified="2013-05-29" version="1">MWKIKFIIFWILGISLLYGVEGIPILGFPVNSQVPPVARVSQPFLYKFAGNTFYNIQGSVRYSVDRLPSWLHFNPQERTFFGTPSRSDMGAIKFDLIATDSTGSAKNPVTFVVVDFPAPTLKIPLVQQLRMHGTIDLNGAFVVLPNQAFSFILDKNTFDARNTRIMTYYCVSGDNTPLPSWVKFDPKTLKIWGIAPSIQSKGVPPLYFWFNVIAADVLGFSGGVASFGIVVSLHHLQLGRSYYSITAVVGRSFVFPFPANSLTKGGVPISSSEASRFKYSISTSSWLSYNKNNLALVGTPSSMESPQNVIVVIMDGTYGITVFIRVNIGDHEILPRILQGPLQESLSRCASGDPSCSPVSVEMASKNTNVAPKVSTLPNINAISGKFFSYRIGDPSSLSSNDRVELQYSPSDASKWLNFNRDTMRISGVPSDEGTVNVKIHTVYGSGRSRDQYFSIYINKGDEENTNKKDLKWFIVGAVAFVFLFILFLILFCCIRRSKRRRSSTDHRYISRPIPPDSRYGQWPTMDEKTWDEPHRLSAFNIFKSTSANGLSGFVAEVKEAPDNTKSLDSNKKYRKTDVTSPYSIHVLPIKDEPIKKSTVFVSKGNMHPASNNSDVSSFLPMGPPGYGQPHRSWRRTTQGSFFWPSSSTYDESVMASGFKDSQANEPYTVRLVNDSITHSDESSGVISNAITSSTSHNSSNDLSRKTSDSKITLGSYSEDSIISKASISQNREDNDTHRLRKNDTYSRVRPWSAHLSERDSIDSLSLMSSEHSRNEFLCDEADNPYSSYFGDHNKRSQPIRGISGSDPLQFHIPTRLSTSLHTSIQSSSKSEISSSIPNRKTPILIKPTMVDRPKLFEYSRSNRTNTHSHIPSRDLSSKIAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJV7</accession>
    <name>M7PJV7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Succinate dehydrogenase [ubiquinone] cytochrome b small subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_00883</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CybS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872794.1">
        <property type="nucleotide sequence ID" value="XM_007874603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJV7"/>
    <dbReference type="STRING" id="1069680.M7PJV7"/>
    <dbReference type="GeneID" id="19894581"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00883"/>
    <dbReference type="eggNOG" id="KOG4097">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096618_0_1_1"/>
    <dbReference type="OMA" id="SEGSYHW"/>
    <dbReference type="OrthoDB" id="18577at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03496">
        <property type="entry name" value="SQR_TypeC_CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] cytochrome b small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007992">
        <property type="entry name" value="CybS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05328">
        <property type="entry name" value="CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <note>ligand shared with SDHC</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <note>ligand shared with IP/SDHB</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR10734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="154" mass="17245" checksum="2275D47CC12D41ED" modified="2013-05-29" version="1">MSPFRVVKFHTWSPLYFKAFFMKKGIGKASPQVIVGSVNDPSPTPLPSPIHGSYHWTFERLISLTLVPLVLAPFVGSSTTPIFDAILSLGLVVHSYIGFDSCITDYFPKREYGSFSTFMRWVLRSATGLVFAGLYEFETNDVGITEGIKRIWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7PK14</accession>
    <name>M7PK14_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-mRNA-splicing factor CWC26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872829.1">
        <property type="nucleotide sequence ID" value="XM_007874638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PK14"/>
    <dbReference type="STRING" id="1069680.M7PK14"/>
    <dbReference type="GeneID" id="19894615"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00917"/>
    <dbReference type="eggNOG" id="KOG2654">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024195_0_0_1"/>
    <dbReference type="OMA" id="NGFENRW"/>
    <dbReference type="OrthoDB" id="6022at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070274">
        <property type="term" value="C:RES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018609">
        <property type="entry name" value="Bud13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051112">
        <property type="entry name" value="CWC26_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809:SF0">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09736">
        <property type="entry name" value="Bud13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="36268" checksum="D03450998169798B" modified="2013-05-29" version="1">MSLASYLAKKYLNKEVIKKDKKKEIKDDIVHIIDGDLTGWKEIKSDIKKKASILKNDLKKELEKEQEGIKKGFKKASYSSWEKVEGPESNSEAQDTPVVIVSEEKNDIDIKMESKNECTMSSGARAGLQTAKQVADDIKRQKDQERAIFKTVDPKLTGKNAETIYRDASGRRVDIELAMMERQRQKAKEEARKKLEHEMSQGEVQKREKEEAKKAMEAIKYEPFSRSIDDPELNRMLKEKERWDDPANAFLSKKQQSTRPTYQGFYSANRFGIAPGYRWDGVDRSNGFEKAWFAYRNEKKAQAAEAYAWSIEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M7PK71</accession>
    <name>M7PK71_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872904.1">
        <property type="nucleotide sequence ID" value="XM_007874713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PK71"/>
    <dbReference type="GeneID" id="19894688"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00990"/>
    <dbReference type="HOGENOM" id="CLU_1332426_0_0_1"/>
    <dbReference type="OrthoDB" id="5386494at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="206" mass="24296" checksum="6A9FFCEDE287ACD5" modified="2013-05-29" version="1">MHMEGPSTPPEQIQRLPPTPPTPFYTSSRNNLICPLEKQKYTKRLSSWLETPCPVAKDVLLSPKKTPQNIFEKKEEKCINQIKSTFLSRNISKKREKKCNKDDSVEKMFFYDEKNPFFLKSKEIFNTEKEPIKKLNKTHNPEGFSFLFRGKKILQPFTDDAYDLKPKQLFAEMLSSLNTTIDEMNDEFTPSKRKRRKNNLDRLNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M7PME4</accession>
    <name>M7PME4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00083</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871939.1">
        <property type="nucleotide sequence ID" value="XM_007873748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PME4"/>
    <dbReference type="STRING" id="1069680.M7PME4"/>
    <dbReference type="GeneID" id="19893781"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00083"/>
    <dbReference type="eggNOG" id="KOG0596">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_375570_0_0_1"/>
    <dbReference type="OrthoDB" id="20524at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990813">
        <property type="term" value="P:meiotic centromeric cohesion protection in anaphase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033316">
        <property type="term" value="P:meiotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14131">
        <property type="entry name" value="PKc_Mps1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000131">
        <property type="entry name" value="Dual specificity protein kinase TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000224">
        <property type="entry name" value="serine/threonine-protein kinase mph1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027084">
        <property type="entry name" value="Mps1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF21">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="398"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="740" mass="84403" checksum="B403C3DC15A6E30C" modified="2013-05-29" version="1">MKSQDIQMNTQNLSRKVSKISLDFSTEEASDNEFEFESAYARMLFAKDRKSGERNCIEDNKYDIKKIRKKRSIKKERESPNEILKQNIEESNSTLQTIRSMENAGRNYIYDKKNDFIEKSINYHKNLKYTEELQSMPQKELVDISAFSNSMALITAQTKINQHSQESHTFQTPALKQSWGINASSSARWKRIGRIGLGPPKRAERLSSESVDELENGTEVRQEDSKLPFLGAEKQDIQTFNGGKENIPHEHIMNKENQFDIFPVLSNSTSPIENQKTSPKKFKKMQSLLINPVNCLQDTDLIVQNKNESVLPVYISKSSLFENLQKNIETNSPKDSSIKKSDSCCLQSMLKSEKKNSVDVNDNVLPQTNSPNTKTNLSSLQNVSSKSKSITYVNSKPYNRLDLIGRGGSSKVFRVMDQNHKMFALKKVHFDKADKSAIVNFKDEIELLKKLSGHERIIKLYDSEINDTKGYLTMILEIGEIDLSHLLAKQHQRPLDINFVRLYWDQMLQAVQAVHDQKIVHSDLKPANFLLVEGSLKLIDFGIAKAIGNDTTNIHRDSQIGTINYMSPEALSEAHSSTPGEQKVMKLGRASDIWSLGCILYQMVYGKTPFAHLTMFQKIKAIPDPKHSINFPTMAFPIAHNGQSQPDGVRVNKNLIKVMKSCLERDQTKRKTIPELLQDRFLQPEKHLQNEKPTVRLTLEQMIQLVEQIVEAVKSEKHTLEQLKAATNESFARLLEIQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7PMW5</accession>
    <name>M7PMW5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-oxoacyl-[acyl-carrier-protein] synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_00216</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 11">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872084.1">
        <property type="nucleotide sequence ID" value="XM_007873893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PMW5"/>
    <dbReference type="STRING" id="1069680.M7PMW5"/>
    <dbReference type="GeneID" id="19893914"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00216"/>
    <dbReference type="eggNOG" id="KOG1394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_69_2_1"/>
    <dbReference type="OMA" id="QIGHCLG"/>
    <dbReference type="OrthoDB" id="5334845at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000015">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000024">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005589">
        <property type="entry name" value="PRK07314.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712:SF336">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="POLYKETIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="12">
        <location>
            <begin position="1"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="10">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR11789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="430" mass="46242" checksum="A7B813866F5B97D5" modified="2013-05-29" version="1">MKRVVVTGLGLLTPLGTGVKHCWSRLLRGESGIVSLKGREGDERYERLPSKIGGIVQKGSFTDGLWDSEEWIDKEDRHRMATFSQYAVCASIQAINDAGLDGYSGESVGVCIGSGIGSLEDLVEMSNKFTQYGWKKVVPLFIPKILVNMAAGYLAIKYGFRGPNHACSTACSTGNHAIGDAFRFIQYGDADIMVAGGSEAPIHPLAIAGFSRIKSLATKYNDMPSKSSRPFDRDRCGFVIGEGSGIVVLEELEHARARGARIYAELRGYGLSCDAYHITSPSQDGLGPQLSMRNALKHARINPSDVDYINAHATSTPLGDMVENKAIKCVMLGPNGKSNAKEINVSSTKGAIGHMLGAAGAVESVFTILAIYHGVLPPTLNLENPGEPSEEFNCNYVPLYAQERKIKIALTNSFGFGGTNATLCFTAYND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWV9</accession>
    <name>A0A0W4ZWV9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_04334</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="KTW32858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613338.1">
        <property type="nucleotide sequence ID" value="XM_019757846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWV9"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZWV9"/>
    <dbReference type="GeneID" id="19896570"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04334"/>
    <dbReference type="OMA" id="TRFCAYF"/>
    <dbReference type="OrthoDB" id="446293at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000014">
        <property type="entry name" value="Protein hob3, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="4">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KTW32858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="246" mass="28729" checksum="4C498857A12415CC" modified="2016-03-16" version="1">MIKAGHVEKTVDREFDIEERRFHTMEQAVLRLQREAKNYLDSLRSMSASQLRIVEAMDEFYTDTYHKDRASKHYRQAAEDFDSRTMKELDEIYRLTVLDPISKFCTYFPEINAAITKRNHKLVDYDAVRAKVKRLTDKPSDDIRKLPIAEKEAAQAKELYVSLNSQLLKELPEFIDLRVPYLDASFEALVKIQFQFCYDGYDRMSKVQQYFASNVRNQYSTGNLDQKIDDVLQKVKNLSIAGLGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWW1</accession>
    <name>A0A0W4ZWW1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">I/LWEQ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_04001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLA2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="KTW32862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613341.1">
        <property type="nucleotide sequence ID" value="XM_019757760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWW1"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZWW1"/>
    <dbReference type="GeneID" id="30671537"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04001"/>
    <dbReference type="eggNOG" id="KOG0980">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FQMSVEM"/>
    <dbReference type="OrthoDB" id="10262320at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043325">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17007">
        <property type="entry name" value="ANTH_N_Sla2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1410.10:FF:000004">
        <property type="entry name" value="Cytoskeleton assembly control protein Sla2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000021">
        <property type="entry name" value="Cytoskeleton assembly control protein Sla2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035964">
        <property type="entry name" value="I/LWEQ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002558">
        <property type="entry name" value="ILWEQ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030224">
        <property type="entry name" value="Sla2_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407:SF15">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01608">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00307">
        <property type="entry name" value="ILWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109885">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50945">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="7">
        <location>
            <begin position="20"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="I/LWEQ" evidence="8">
        <location>
            <begin position="800"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="384"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="468"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1009"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KTW32862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1047" mass="120193" checksum="BB390688E641EAE4" modified="2016-03-16" version="1">MDYRYQEHRNKDSYISRNIDLNRSESDLAVNIKKATSIKETAPKRKHVRSCIVYTWDHKSSLSFWAGLKAQPILSDDIQIFKALICMHKVIQEGHPVTLQEAQAQKSWLEICSRSVIGGNVKGYGNLVKEYVEFLIAKLSFHKLHPEFNGMFEYDEYLTLKNTSDPNEGYETITELMQLLDRIDLFQKTIFLHFRSGSTNECRIAALVPLVQESYGIYKFITSMIRAIYHSTQFSEGIKPLKLRYNSQHHKLVKFYYECSNLRYLVNLISIPKLPQDPEDLIEDFELSSQKFSIQEKDSLSEGSSKNENNHDISKSSNILSISQMQKTPTYEELQAQKETEYAKQEFDQQKLAHERLLNEQYQAYIQNRVSELEQEVFNMHGQYNRDQHMLEQYDKKVKILENELQNLNINASQQIESKDSYIKSLQDQIIMWKNKYESLAQLYTQLREEHIDFLSKFKQVQLKAASAQESIEKKEKIEKEMDSKNMELTIITRERDRLKLDMDKLKNQKEELDKINKNLMSSLEKTESSEKSKSLELSSLTSKYNKEVSDFEKLLLAKQEMIDEISLKLQESYDQLETVSKEKDDELEIYKAEMDSAFMKLNDLHMNNRNMDSAINSEINRILTDNSKKLNNIIDAILQSAIQIIDNSLYELVSPMQTGNQNSTPEYLLSTIEKGSSNAMDFFTTFSNFIVDSPNGDHSEIIRLINIFSSSVSEILTNAKGIVRLAGDDDIGERLISYAHDFAITSQRNLEALQTHSLIDLSDEKKIEIVISKNLDVQLCLKKLAQLSENFVPKEIVDLVANSKEDIGDLVDRELRNASHAIEEAAARLSKLKERPKDLQFTCSELQIHDSILEAAIVITNAVSRLIRAATDSQNEIVSQGKGSSTRAAFYKKNNRWTEGLISAAKTVAGSTNILIETADGVINGRNIHEQLIVASNEMAAATAQLVAASRVKASFMSETQQKLEDASKAVSLACKTLVKQVQDIVESRFQQDNIFDYSKLTPHEFKVHEMEQQVEILKLENQLANSRKKLGEMRKVSYYKEIIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWX6</accession>
    <name>A0A0W4ZWX6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_04314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="KTW32871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613349.1">
        <property type="nucleotide sequence ID" value="XM_019757830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWX6"/>
    <dbReference type="GeneID" id="30671593"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04314"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KTW32871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="59" mass="6680" checksum="4E1EBF0683E6E4E5" modified="2016-03-16" version="1">MADEDACLQLKIHGIIQMNDKKSLEEVGLEDGAILEFSRLHNGVWEPFESESYPESNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZX25</accession>
    <name>A0A0W4ZX25_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_04279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="KTW32910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613382.1">
        <property type="nucleotide sequence ID" value="XM_019757800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZX25"/>
    <dbReference type="GeneID" id="30671571"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04279"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KTW32910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="71" mass="8533" checksum="4FDEC5D1D2DB1461" modified="2016-03-16" version="1">MFYSVLLQNIYFLCVFFDEVFKALSKRNHNRRLLHTLTNTCAREKRRRKKVESGQGKKVKVRDDILNSDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZX42</accession>
    <name>A0A0W4ZX42_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_04257</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="KTW32935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613403.1">
        <property type="nucleotide sequence ID" value="XM_019757780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZX42"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZX42"/>
    <dbReference type="GeneID" id="30671554"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04257"/>
    <dbReference type="OMA" id="RMVMIAN"/>
    <dbReference type="OrthoDB" id="189226at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="5">
        <location>
            <begin position="106"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KTW32935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="362" mass="43422" checksum="CDEED6BFEB8F9F76" modified="2016-03-16" version="1">MQKKQLIKNITILCQWSGRILVFIGFICVSIAIAILQLLATFFYKYKQNWYYKYIRRTKKHAGVICMAIAKLLIPSYAILYGDKIILSHFEKDLNKKEEIEESNRFIFISNHQIYIDWFYIWWIAYLKKIDNGIYIVLKDSLKRIPIIGMKTFGFIFLSRSWQEDHLRFNNHFRNLSLSANQSMLLLLYPEGTNISLHTKHQSLAYVKKNDLPILDYVLLPRIKGLYFCLKNLHKTTKYLYDCTIGYEGVTHNTYAQDIYTLKSILFDGQFPKNVHIHLRRFSIDTVPLDNEDQFKNWLYNLWIEKDKLMHQFINHGYFPGDFTLKRKIQLDSILEILSLWDVYIVIFLFIIFIYYFLKIIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7NIC8</accession>
    <name>M7NIC8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL49</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_03154</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL49 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875216.1">
        <property type="nucleotide sequence ID" value="XM_007877025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NIC8"/>
    <dbReference type="STRING" id="1069680.M7NIC8"/>
    <dbReference type="GeneID" id="19896841"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03154"/>
    <dbReference type="eggNOG" id="KOG4034">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085757_4_1_1"/>
    <dbReference type="OrthoDB" id="19439at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007740">
        <property type="entry name" value="Ribosomal_mL49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477">
        <property type="entry name" value="MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05046">
        <property type="entry name" value="Img2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="106" mass="12341" checksum="38507FA3DA26B7FE" modified="2013-05-29" version="1">MNIFKITEIKYRFARSFFSSIPLRAYFVRRTRFGSLPVYLDIKGGGTKHLTLIRKVEGNAHELCKKLEKDLKLSQKELFVNNLTKHVIIKGSRVNEVKEILIKDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NIP2</accession>
    <name>M7NIP2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="7">3.4.21.92</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_03291</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="7"/>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875366.1">
        <property type="nucleotide sequence ID" value="XM_007877175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NIP2"/>
    <dbReference type="STRING" id="1069680.M7NIP2"/>
    <dbReference type="GeneID" id="19896978"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03291"/>
    <dbReference type="eggNOG" id="KOG0840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058707_3_2_1"/>
    <dbReference type="OMA" id="IHQPYSE"/>
    <dbReference type="OrthoDB" id="2017408at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009368">
        <property type="term" value="C:endopeptidase Clp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000001">
        <property type="entry name" value="ATP-dependent Clp protease proteolytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001368">
        <property type="entry name" value="PRK00277.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381:SF11">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="250" mass="28159" checksum="2EF6B8C00F65BC7C" modified="2013-05-29" version="1">MKLSQLYSTYFREREFFGYIDRKCLLKFQIRLFSHIPVPYVIEQTGRFLNTFDIFSRLLRERIVCLNGAIHDGVSAVIVAQLLFLEAENPEKPISLYINSSGGNVTAGLALYDTMQYIRSPVSTLCIGQASSMASLLLAGGAPGQRYALPHASIMIHQPSGGVSGQASDIAIHAREILKVRERLNLIYQKHLTRIKDLNDIGKFSNNLLLLTALEKIMERDYFLTPQEALELGIIDEILVKRNKESIKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NIT5</accession>
    <name>M7NIT5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GRAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_02996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875045.1">
        <property type="nucleotide sequence ID" value="XM_007876854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NIT5"/>
    <dbReference type="STRING" id="1069680.M7NIT5"/>
    <dbReference type="GeneID" id="19896683"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02996"/>
    <dbReference type="eggNOG" id="KOG3294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1372711_0_0_1"/>
    <dbReference type="OMA" id="SNRLEDH"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13214">
        <property type="entry name" value="PH-GRAM_WBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044852">
        <property type="entry name" value="WBP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606:SF1">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="22626" checksum="AD28A5A45BF6A1BD" modified="2013-05-29" version="1">MSINSVDVNPENEPILLPFEQFFFCGNKVEFILECGNGYPANHIINKTYSSSSGRLYFSNHRIIYFPSQATASFKNFACPLNKFVDGSFIQPWFSSNYYQATVYPVPQGGLPSVASVKFIFKEGGGFDFATKFSDIQFRLHENNNDPRYVQHLEELPQYQAHDSSLLPNVNQLIIDDIPSLSYVNRDAPPNYEDVAKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7NKF9</accession>
    <name>M7NKF9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Vacuolar protein sorting-associated protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02466</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the VPS29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874475.1">
        <property type="nucleotide sequence ID" value="XM_007876284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NKF9"/>
    <dbReference type="STRING" id="1069680.M7NKF9"/>
    <dbReference type="GeneID" id="19896159"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02466"/>
    <dbReference type="eggNOG" id="KOG3325">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063749_0_1_1"/>
    <dbReference type="OMA" id="VRGNMDY"/>
    <dbReference type="OrthoDB" id="10258130at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07394">
        <property type="entry name" value="MPP_Vps29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000015">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028661">
        <property type="entry name" value="Vps29"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="190" mass="21305" checksum="AB7E2987EC7131E0" modified="2013-05-29" version="1">MLILLIGDLHIPSRALDIPVKLKKLLVPGRISQILCTGNLVDHETSDFLQTVAPDVHFVKGDFDQSRGWPLSRVIAIDSFRIGLIHGHTVVPRLDSDALHMVARQMDVDVLVWGGTHRFEAYEWDGKLFVNPGSATGALYTGWETEEPIPTFVLMSLQTTVLVLYVYQLIGDDIKVEKLQYPRGKTENTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NKR4</accession>
    <name>M7NKR4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874582.1">
        <property type="nucleotide sequence ID" value="XM_007876391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NKR4"/>
    <dbReference type="STRING" id="1069680.M7NKR4"/>
    <dbReference type="GeneID" id="19896260"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02568"/>
    <dbReference type="eggNOG" id="ENOG502QWBK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044538_1_0_1"/>
    <dbReference type="OMA" id="CGPDFRQ"/>
    <dbReference type="OrthoDB" id="341300at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16279">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663:SF6">
        <property type="entry name" value="HYDROLASE C777.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663">
        <property type="entry name" value="HYDROLASE C777.06C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="67"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="310" mass="34843" checksum="96BFC4AB34764937" modified="2013-05-29" version="1">MAQAKPVELIFLGTGTSGSVPSIHCLTQNPPTCSVCIDATYINSKNRRRNTSAVILIKDCNDDLKTLVIDCGKTFYEATLEYFPRYSLRKIDALLITHAHADAINGLDDLRGWTLKGLIQDYIDIYLTSETMDTISTTFPYCVYPEKATGGGDVPSFRFHIIDFIHPFIVESCGNITIYPLKVQHGVFQNKQGNKLPFYILGYRINNLSYISDVSVIPDETIDIIKGCEFLVLDALKEQPHLSHFSIPQALDFLSHLSPNLPKKIFFIGFDHSIAHDDLEKRLSQEIQHGILKNTCILPAYDGMRISLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M7NKU9</accession>
    <name>M7NKU9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PNEG_02592</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 14">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874607.1">
        <property type="nucleotide sequence ID" value="XM_007876416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NKU9"/>
    <dbReference type="STRING" id="1069680.M7NKU9"/>
    <dbReference type="GeneID" id="19896284"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02592"/>
    <dbReference type="eggNOG" id="KOG1376">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015718_1_1_1"/>
    <dbReference type="OMA" id="YMASCIL"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098863">
        <property type="term" value="P:nuclear migration by microtubule mediated pushing forces"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000008">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 14" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="15">
        <location>
            <begin position="49"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="16">
        <location>
            <begin position="248"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMR09258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="449" mass="50292" checksum="15B97E6FD8172BDB" modified="2013-05-29" version="1">MREVISIHVGQAGTQIGNACWELYCLEHGIEPDGRLSAEKTSKPLDDGFSTFFSETGSGKYVPRSIYVDLEPNVIDQVRTGTYRQLFHPEQLITGKEDAANNYARGHYTVGKELIDHVLDRIRRVADNCTGLQGFLVFHSFGGGTGSGFGALLLERLSVDYGKKSKLEFSVYPAPQVSTSVVEPYNSILTTHTTLEHSDCSFMVDNEAIYDICRRNLDIERPGYENLNRLIAQVVSSITASLRFDGSLNVDLNEFQTNLVPYPRIHFPLVTYAPLISAAKAHHEANSVAEITNACFEPNNQMVKCDPRNGKYMATCLLYRGDIVTKDVNSAVSSIRTKRTIQFVDWCPTGFKLGVCYQPPQYVPDGDLAKVSRAVCMLSNTTSIAEAWSRLDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGQDSIEGEIMEEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NL91</accession>
    <name>M7NL91_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02376</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874382.1">
        <property type="nucleotide sequence ID" value="XM_007876191.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NL91"/>
    <dbReference type="STRING" id="1069680.M7NL91"/>
    <dbReference type="GeneID" id="19896069"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02376"/>
    <dbReference type="eggNOG" id="KOG2476">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019955_2_0_1"/>
    <dbReference type="OMA" id="IVPITHY"/>
    <dbReference type="OrthoDB" id="444325at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061632">
        <property type="term" value="F:RNA lariat debranching enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07380">
        <property type="entry name" value="MPP_CWF19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF4">
        <property type="entry name" value="CWF19-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc knuckle CX2CX3GHX4C" evidence="6">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="5">
        <location>
            <begin position="394"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="4">
        <location>
            <begin position="538"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="617" mass="71993" checksum="E8016BC0265622D7" modified="2013-05-29" version="1">MNHNTSKVLFFGSSNGNFKKIFEKTHDLNKKHNFDFLFCIGDFLPESGTDELEIIDLLEGRIQIPITTYFSIGKQRLHKKVEKKAIKNNGEICKNLFYIGKLGTLTTSKGIKISCLGGMYEEKQFYCKILPEDTEIKPYIYESEVDFIMKKGKDSDILVTFEWPKDIHKFSCKKMSKMIPGVQSIAKVTSYIQPKYHFSSNGSIFYEREPYKNISIEDRQKTNITRFISLGSLDNPDKERSSYAFNITASSLYDTSNTLNIPNVTRNPFTEEINTNSKEIKHNLEDSQYTFFWNKESSNSIKRQKHDTEISKSYDHIIKKEKKETNSDQVPQNCIQIHNITDHLIYNSSKLNKEKYEKESTIPPNYTCKICMQKGHWIQNCPQKKTTASRKPIRNHPKLEFCFFCLSDPRIARHLITSIGSETYLALPKGPLTTSSTNSPSLSFPGHVLIIPIAHVPTINAIEEVNRDKTKEEMERYRISINEMFKSKGCDTVAFEISRINGIHLHWQVIPIKKNLSDELENTFISMGNEKKYNFEKRDIKKDEENYLRIWLPNNTILVHIIKPETYFDLKFARYVISKVLNLEERSDWKNCVQTNEQEFQDSIQFKKHFKDFDFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLM1</accession>
    <name>M7NLM1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL32m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02149</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874130.1">
        <property type="nucleotide sequence ID" value="XM_007875939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLM1"/>
    <dbReference type="STRING" id="1069680.M7NLM1"/>
    <dbReference type="GeneID" id="19895842"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02149"/>
    <dbReference type="eggNOG" id="KOG4080">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2185089_0_0_1"/>
    <dbReference type="OrthoDB" id="2014905at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051991">
        <property type="entry name" value="Mitoribosomal_protein_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL32M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="109" mass="12634" checksum="F18E06EA92E9E331" modified="2013-05-29" version="1">MFGVFLGLIIEKYVQPTIISWIPTFISTGKYSALIPMKYGYGMSFESILWAAPKKKTSYSKKRMRQATKGLRDIQHLNYCSACGKKKLAHTLCLFCYKEIKEFIKSKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLM6</accession>
    <name>M7NLM6_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02154</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874135.1">
        <property type="nucleotide sequence ID" value="XM_007875944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLM6"/>
    <dbReference type="STRING" id="1069680.M7NLM6"/>
    <dbReference type="GeneID" id="19895847"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02154"/>
    <dbReference type="eggNOG" id="KOG1508">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072852_0_0_1"/>
    <dbReference type="OMA" id="PGKEFPN"/>
    <dbReference type="OrthoDB" id="19419at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140713">
        <property type="term" value="F:histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="217"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR09568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="250" mass="29191" checksum="2F4C928D68A805FE" modified="2013-05-29" version="1">MSLKRINEKRPEILPESNPTSLDEVADIELEFEKADVELLKHQVQLFNPLYEKRANVLRKIPKFWPIALEAAPSDEFSVYINPEDANVLEHLIDLRVYRPNEDPRDIKIVFEFEPNEYLESNSLYLEKLFRYSSQKAEASSSNTDKEPSQLISEKVNIKWKKNKDLTKPTKGVAPSFFTWFLWTGENNDIFEDGEELAIFIAEDLYPNAVKYFTDALQENEENDDEEIDLENENGDNISEEEPPKKKTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLY2</accession>
    <name>M7NLY2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_03588</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FKBP-type PPIase family. FKBP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 6"/>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875682.1">
        <property type="nucleotide sequence ID" value="XM_007877491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLY2"/>
    <dbReference type="STRING" id="1069680.M7NLY2"/>
    <dbReference type="GeneID" id="19897275"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03588"/>
    <dbReference type="eggNOG" id="KOG0544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013615_12_1_1"/>
    <dbReference type="OMA" id="FTSMNNQ"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000025">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050689">
        <property type="entry name" value="FKBP-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516:SF443">
        <property type="entry name" value="FK506-BINDING PROTEIN 59-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="20"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="111" mass="12121" checksum="411E5FCF7E2EC659" modified="2013-05-29" version="1">MGVIKKTIREGNKKDYPTKGDRVSIHYTGTLENGKKIDSSYDKGKPFSTIIGTGQVIRGWDEAILQMSIGEVAELTITGDYAYGQVGYPGIIPPNATLIFEIKLLEINGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NM18</accession>
    <name>M7NM18_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_03357</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875439.1">
        <property type="nucleotide sequence ID" value="XM_007877248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NM18"/>
    <dbReference type="STRING" id="1069680.M7NM18"/>
    <dbReference type="GeneID" id="19897044"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03357"/>
    <dbReference type="eggNOG" id="KOG3166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055193_0_1_1"/>
    <dbReference type="OMA" id="RMVKWPA"/>
    <dbReference type="OrthoDB" id="29563at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="131"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="258" mass="29628" checksum="16E50007A2430DB8" modified="2013-05-29" version="1">MPSKANAGKKIVETFPTESSTTKSESKNPLFEKKPKNFSIGQDIQPKRDLTRFVKWPRYVQIQRQRRILSMRLKVPPAIYQFNFTLDKNVALELFKLLNKYRPETKIEKKQRLLSKAENNFKGIIAKDLEKKPFYVKSGLNHIVSLIENKKASLVIIANDVDPIELVVYLPSLCRKMGVPYCIIKNKARLGTVVHRKMSAVLAFTEVRSEDKNTLATLISAIRVNYNDKYDESRRIWGGGIMGQKSINNAIKKQKTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M7NM29</accession>
    <name>M7NM29_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_03367</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875449.1">
        <property type="nucleotide sequence ID" value="XM_007877258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NM29"/>
    <dbReference type="STRING" id="1069680.M7NM29"/>
    <dbReference type="GeneID" id="19897054"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03367"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1737">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001040_1_1_1"/>
    <dbReference type="OMA" id="LPEMKGW"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000001">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF205">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="195"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="261"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="496"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="943"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1027" mass="118168" checksum="82091AE16A9C54AB" modified="2013-05-29" version="1">MSVNALDLSKKVGAEECLRTFRLLKAFRSGDIHAVDKCFDNYEKDLPEECTRTPTSSIKAFDLFSPLILAVQCASASIVEHILHKNIFDVNHKDDYGNTALHLAVYMCRFDVIKMLLLNANINDTILNNNRKQAYELSTSSEIHHYMIGERARFIEKTEEKFSQLIFFKKYDEIKKMLEIPRVSALLDLNKVDKNGSTFLHEAVKGNDMQILQILLDHGADPLKVDKNGRTPSDIAKDDLIKRKLLVSSSDGVVVTFPGEPIFMSGYMDKWTNYKSGYKKRWFVLRNDDADTECRGSINMRTARINYGSGDKRAFEILCCDSVKYSVKVTNPSEARKWVWALTNSIQWAKDENVTIIDDTSKFSPKEREKVPLKESGLYLPFQYLSCNDLDDDESSETCDPGESCKDNFLITMNSFRIQLDILSQIFDDVLSNFDSISEKGLNSKMESFVEAFYQSIDSLRGALGNLDQIFLDGEKYWKRMINKEKRMRILWEENMHKLASEQEEIEKNLQNAENERRRAKKALRQAKRKLNFTPKIIRSSSDGVKSENDFETHDSFLDLRSNRSLQNTDIENNSLDDNDSSSSPDEFFDVTNSIETKIDKILTFDSTGEKISQKKSIKEMQIELSYHGYEDPLRLKLDLIDDRPKLSLWGMCILKSMIGKDITKITLPVSFNEATSLLQRVAEDMEYIDLIDISVTLPESYDRMLYVAAFAISEYSSTINRIAKPFNPLLGETFEYCRPDKGYRFIVEQVSHHPPISAAHAESLNWEYWGESRVSSKFYGRSFDINPLGTWFLRLHNDSGLDELYTWKKVTTSVIGIITGCPTVDNFGEMLIKNHSIGDVCTIDFKKRGWRGDGAYEIKGIITDSKGISRWSIGGHWNDKLYAKRMNGISVATDTAILLWQNHERPPAPFNLTPFAITLNALPEKLKPWLPPTDTRLRPDQRAMENGEYEFAAKEKERLENKQRAARKERELKGEIYVPRWFEKSINKITGDEQWLFNGEYWKLREILGSNNQKSDAHSWGVMDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>M7NM94</accession>
    <name>M7NM94_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">BAH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_03162</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875225.1">
        <property type="nucleotide sequence ID" value="XM_007877034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NM94"/>
    <dbReference type="STRING" id="1069680.M7NM94"/>
    <dbReference type="GeneID" id="19896849"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03162"/>
    <dbReference type="eggNOG" id="KOG1827">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_365284_0_0_1"/>
    <dbReference type="OMA" id="PPYWYLG"/>
    <dbReference type="OrthoDB" id="1742084at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04717">
        <property type="entry name" value="BAH_polybromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF21">
        <property type="entry name" value="CHROMATIN STRUCTURE-REMODELING COMPLEX SUBUNIT RSC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="11">
        <location>
            <begin position="28"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="11">
        <location>
            <begin position="246"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="BAH" evidence="12">
        <location>
            <begin position="347"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="129"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="711"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR08322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="764" mass="88200" checksum="C7DC2DC5EABE890C" modified="2013-05-29" version="1">MSHVPLTKAHKEAIKKLLDVLYNAVDSSGRSISKIFEELPDKKEVPDYYEVIKKPMALNVIKENVNKNLYNVFHEFITDVAQIYYNAKLYNRRSSVIYSDACLNEMIIAKELSVLKDKNLVDDSILPVLGPLPPSSQGEEKSDDDGFDPDIEDKNEEDDDDDDEARHKRRRKEVKIKPYEPTKAMRFDIGDIKRKRGRPPKVDTPDEARMKIILRVIRKEKDERGRTLFTWFEKFPDDKFSQINKIKQTISLEDIRQKLKRREYKTLKNFLDDLDLLYNNVKLISPPGSNMYRDADFLQQVTHEVASIEASRRDIDFTGYKKDPTSSIGTLIKVNRTPLPKIEVKGEILEVGDWIHLVNHNDVNKPIIAQIFNLWENLEGEKWISVCWYYRPEQTVHRADRIFYENEVFKTGQYRDHQINDIIDKCFVMFITKYIRGRPKDAGNKSIYVCEFRYDEETKVFHKIKSWRACIPDEIRNKEYDMYCFERQQQPKRTLSPILHLLPSKVIEDPNAPIPEPTQGKENAPPIIGAIIPAPIPDESTLNPPEIFMPSVVSASIIPQKPIIPSLVTQTHASVAISPNSQSQTSRKVHIPYYPPVAFTLPVSNLISKNDIENPVDKNNEGINGDMDINIREEIDEDEIERNENDNLEIENGDKIENVKGMRKSNNFSDEVAALFSQDEQGRVLWFPVPPIDVVAPAVDTFVKGRSLAYLANVDNMMEKYKKDSEEEKEQKTNIIKTSDDSEFSGFLIAALDKMTQNIKSSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMB1</accession>
    <name>M7NMB1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TPR repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_03187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875250.1">
        <property type="nucleotide sequence ID" value="XM_007877059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMB1"/>
    <dbReference type="STRING" id="1069680.M7NMB1"/>
    <dbReference type="GeneID" id="19896874"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03187"/>
    <dbReference type="eggNOG" id="KOG1128">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004905_0_1_1"/>
    <dbReference type="OMA" id="WNIRLIC"/>
    <dbReference type="OrthoDB" id="1936594at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044244">
        <property type="entry name" value="TTC27/Emw1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="556"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="590"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="855" mass="99392" checksum="A05186B259751EA5" modified="2013-05-29" version="1">MTINLKKKDFYMLEWALIKGQNININIEIGKLIQLVIDGDFKTVFLSPKIQRIFKKNQKHVNIIEESKSYNLETYIEDRISDIPSTLEGELLLLLLAVSSIHVFIQIHFTGPKPIFDSYILLPEEWKIEYTEICLRKDVLKCLEIGSAYPYHLIQCPIFLLISKIILSRTFKYSKTCFWWKARVNFMHQRILDEQVAILYDCIFENMEKMKKECEEHGSYVYARYALELELCLVYYGKNSKALDIIKDAAEKIGLKWVLTGILGRRTKFQTFDTSQLVLIAKGENSVEEIQEKNQKIPKTLDLNDDTLLETISFKSGKIISSEYLQDSSIPKSLEDIDPNDPPSLSPLDSCILIALTLLIKNTNPNDGLTMEKMAAYIDRVLKHPRNWTVHSMALLIRSKLEMSKGRTMERSILQLQVLVDQLLDDIDSLEDISKNTSFLRKPDSYEESASTKQRLMYSWQLLLIPRWAIEEELADRYLSIGMIRSALEIFERLQIWEKIAICWNALDKKKKAIDVLVSQLAIEPENPKILTLLGDIEENPDYWIKAWYVSGNRYAKAQKSLGMFYYSRQEFEKSAKAFKLSLDINSLNYSAWFTYGCCQLKLNNWEIASQAFTRCVSLDPSDGESWNNLSLSFLKHDPPRKQDAWNALKQALSSCYESWRIWENYLTISLDMLEWNEVIRSIRRCIELRGEKLGENVIDIKILEILVHEVTKNEYTGDEKGFIKNAIELMTSIIPPLITSKPELWRLVAKINIWRKNPSGVLEAYINSYNIWTSKANINTDKDVWIGTVKSAMELVDAYENFGSMKDHMGNLIIPDWKFKAKSILRTLKGKSQTYWSESEEFNRIIESLERFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7NME7</accession>
    <name>M7NME7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein transport protein SFT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_03450</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875539.1">
        <property type="nucleotide sequence ID" value="XM_007877348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NME7"/>
    <dbReference type="STRING" id="1069680.M7NME7"/>
    <dbReference type="GeneID" id="19897137"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03450"/>
    <dbReference type="eggNOG" id="KOG2887">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099529_3_0_1"/>
    <dbReference type="OMA" id="MMSNSIR"/>
    <dbReference type="OrthoDB" id="660759at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF36">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SFT2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="178" mass="20832" checksum="4E0C78A7DFCADE69" modified="2013-05-29" version="1">MINRIRSYPLFHKKYTEILNVNKQDLESSPTDVQQYNKLSYTDRVIIFIICILSSAICFIFAIFLMTTLFKPRKVVLLWTIANLLFLASFSALQGPWTYIKHLFSAPRFPFTCIYLGSMVLTLYFILHLKSTILAIFSSIIQFITLLWYLISYFPMGSQGLHWGFRLIISRIKSYLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMK0</accession>
    <name>M7NMK0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_03186</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875249.1">
        <property type="nucleotide sequence ID" value="XM_007877058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMK0"/>
    <dbReference type="STRING" id="1069680.M7NMK0"/>
    <dbReference type="GeneID" id="19896873"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03186"/>
    <dbReference type="eggNOG" id="KOG0014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_809229_0_0_1"/>
    <dbReference type="OrthoDB" id="1898716at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00120">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="343" mass="39808" checksum="3B7C936A0B923C4D" modified="2013-05-29" version="1">MGKKKIQIKKIMDPKTQITTFSRRRNGLLKKAHELSVLCGIEVTVLIFDEKNKCHVYCSNEEENAAEAMMQKYINKRFKTDTSKKQSESIGLECQLDGTMLEKNQYNFNDRVENVAIIQTYQVIQNDNKKKDMPLAFISSEDSLDKTEGLYVKSKRTYHVYTESPKKDPEAECQKSDSYYLKQLQNGFIDHYQNNNLQTNYTNHAQSTINSDNKSFQSYPYSYMMNNNYNFGKSAPNLLLFSNLENISQNSTPVVHNNLINPICNYSDQTYAESLLDDSLKKFNNQISSDFEIYNQTESNMLNNIMQESYKEMTSSPLSPNDKKYNIPNGILADFQNHLYIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMY7</accession>
    <name>M7NMY7_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_03317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875393.1">
        <property type="nucleotide sequence ID" value="XM_007877202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMY7"/>
    <dbReference type="GeneID" id="19897004"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03317"/>
    <dbReference type="HOGENOM" id="CLU_1917947_0_0_1"/>
    <dbReference type="OrthoDB" id="5318889at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="132" mass="15912" checksum="398841C117222916" modified="2013-05-29" version="1">MDEDKEFVGFLYENCYSYDFEWSDGNDKCKKEMTEDTFLEQKKTWKPKIEDKYILSKTPNPIPRPADKFSLAILKSAAEEQYYLRNYQKSLDYVNDLLKPKDSNLKEDYELCEKEKKQMNYLRNKCLEKLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN29</accession>
    <name>M7NN29_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_03113</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875169.1">
        <property type="nucleotide sequence ID" value="XM_007876978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN29"/>
    <dbReference type="STRING" id="1069680.M7NN29"/>
    <dbReference type="GeneID" id="19896800"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03113"/>
    <dbReference type="eggNOG" id="KOG0810">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042423_0_1_1"/>
    <dbReference type="OMA" id="RWICFIL"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044853">
        <property type="term" value="C:plasma membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070056">
        <property type="term" value="C:prospore membrane leading edge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070057">
        <property type="term" value="C:prospore membrane spindle pole body attachment site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032120">
        <property type="term" value="P:ascospore-type prospore membrane formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15849">
        <property type="entry name" value="SNARE_Sso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000008">
        <property type="entry name" value="Syntaxin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF307">
        <property type="entry name" value="PROTEIN SSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="201"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR08637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="304" mass="35799" checksum="12AEC0CE326C2BB3" modified="2013-05-29" version="1">MKWQSNKHEENEKELEIKGEKEDSNDYELEDLSDKTTLTEFFKKIEDLRNMISTIKENVQQIEQLHQRLLNEITEEQITYLHQQLDDTKARTRHIQNLVRDDIKILEKKNKQSAQTADLQVRLTQTSNIKKKFLESIQNYSKVENSFNQRYRQRLCRQIETVNPNMTQEEIHVALNDDQGMQIFSQALLRSNRHGEARIALQEVQERHQDIKKIEQTIMELAELFNEMNILIEQQDEPLQVISQQAETVYTNIEQGVQHQDKAIENIRAARRKRCYCFGLVVLILIAITIVIIIVKCIGGVCKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN59</accession>
    <name>M7NN59_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873337.1">
        <property type="nucleotide sequence ID" value="XM_007875146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN59"/>
    <dbReference type="STRING" id="1069680.M7NN59"/>
    <dbReference type="GeneID" id="19895098"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01401"/>
    <dbReference type="eggNOG" id="KOG4406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_427066_0_0_1"/>
    <dbReference type="OrthoDB" id="410651at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808:SF2">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="12"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="192"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="641" mass="72420" checksum="866FA63851BF277D" modified="2013-05-29" version="1">MTFTFSCARKKESDSINDQELSALVGRLIFSAGVDDEGRPLVVLNASNFPDSKVVDYDELLRRMLLVMDTFVDENDYSVILFAGGVRHRPRWNWLFQAYQSLGRKYRKYIKVLYIVHSTWWIRVMLDCMNHLVSPKFSQKMIYVSTLSELAKLVPFRQINVPPDVYAHNLKYESHVTLSEMSSESVSQMFGLSLSQLMGNEGENGLPRVVKDICAYIREEALMVEGLFRRSPSSILLKQVREAYDRGNPVRLSEYGPHLAAVLLKLYLRSLPEPLFTHNLYPLLRKISHQSSSKNILFIRNTLLPKLSTPSVILLANVCLLLHDVSLHSKENLMHPRNLSICISPTLVRHPTDPLLDVQLCNLGGGLGMMMVIAIESTYDIFDFVFPLNPESLQSDIIQKIPETSPSGMEQKVSETLRSEMVQKIPETSPSGMEQKVPEALRNGMVRKIHETLHTEILQEIPETIHTEMVREVFESFIPNLVESAPVSYLSQVFSSSPISCVSSLTSEQSRKSISLPESPLFNGVSSLKHEPINESSFLLTSKPNRSSNLTIRRQNLSSLSNLSPTCRRSKTTSVHEMFNSKLRSGIDISPNAKFSLIGSNSLKVKTGLVESLRNLYEEKSILKTSKDFDVSKLQGKRVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNA1</accession>
    <name>M7NNA1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01442</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873382.1">
        <property type="nucleotide sequence ID" value="XM_007875191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNA1"/>
    <dbReference type="STRING" id="1069680.M7NNA1"/>
    <dbReference type="GeneID" id="19895139"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01442"/>
    <dbReference type="eggNOG" id="KOG0096">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_13_0_1"/>
    <dbReference type="OMA" id="NACGVEN"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000369">
        <property type="entry name" value="GTP-binding nuclear protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="216" mass="24699" checksum="A892DB7456DBAA42" modified="2013-05-29" version="1">MANQSQDSIPTFKLVLVGDGDMSIPVFFWKKKTNFGKKYVATLGVEVHPVTFYTNYGQICFNTWDTAGQEKFGGLRDGYYIQGNCGIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLCGNKVDVKERKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLINATLEFVASPALAPPEVQISQEMIAQYQTELLEAQALPLPDEDDVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNE2</accession>
    <name>M7NNE2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Eukaryotic translation initiation factor 4E</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_03112</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G. eIF4E is also known to interact with other partners.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875168.1">
        <property type="nucleotide sequence ID" value="XM_007876977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNE2"/>
    <dbReference type="STRING" id="1069680.M7NNE2"/>
    <dbReference type="GeneID" id="19896799"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03112"/>
    <dbReference type="eggNOG" id="KOG1670">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043552_2_2_1"/>
    <dbReference type="OMA" id="QTEFKMM"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000004">
        <property type="entry name" value="Eukaryotic translation initiation factor 4E-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="38"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="33194" checksum="2AB867D9EECF3161" modified="2013-05-29" version="1">MEEHTKKDLPEKTEIESSVEVEKDEIENQIKKISKIDLEKKENEENKVEDEENDPCESENKDSLRNGVSSNVIDSSENLNSSNVSSVVTVFHNSKNFTVKHPLMHKWTLWFTKPLTPGQRANTTDAWADSLKEVITFDSVEEFWGIYNNIAKASQLPPKSDYHLFKTGVRPEWEDKQNQRGGRWSYNNRDRRSVNIDELWLHIMLAAIGETLENEGDNEVMGVVVNIRKGFVRLGLWTRSTSNEEVLRAIGKRFREAMKIPDKEMIEFYSHSDSAHSGSTRAKSKMYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNF9</accession>
    <name>M7NNF9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Major surface glycoprotein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_03598</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08661.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875038.2">
        <property type="nucleotide sequence ID" value="XM_007876847.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNF9"/>
    <dbReference type="STRING" id="1069680.M7NNF9"/>
    <dbReference type="GeneID" id="19897285"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03598"/>
    <dbReference type="eggNOG" id="KOG3544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010455_0_0_1"/>
    <dbReference type="OrthoDB" id="10515944at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021041">
        <property type="entry name" value="Maj_surf_glycoprot_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003330">
        <property type="entry name" value="MSG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02349">
        <property type="entry name" value="MSG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12373">
        <property type="entry name" value="Msg2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Major surface glycoprotein 2 C-terminal" evidence="2">
        <location>
            <begin position="924"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="779"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="878"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1097"/>
            <end position="1117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08661.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1140" mass="127781" checksum="449DDBC551E6CE64" modified="2016-03-16" version="2">MPLRDKRWVEEVAQKEAAMAQPVKRQAAGQAAGNDEIKEEQVLGLIVKSYYSDDNKCKANLKQYCEELKKIDGKLESVDVKVKGLCENGKEGEKCKELKKKLETELGAFKTEVENALNNLTDEKCRKYEEKCLLLEEADPNNLEEKCVKLRDRCYRQRRQGVAKEILLRALEGKVNNKDECKKRMKEICQGLSEYSDELVFSCFNSDKTCEYLQKNHGDSCKPLEKELEDKELVEKCQEYLEKCYFYGSSCSNSKCDKVKNKCKEKGIEYEGPKLDFSPVKEKPRFPEKIEVENLYKKEEAKGIIVGKPKYKTLRDLALLLIKERNGKDEGEKCKEALKDCESFKHLDYGLEELCGDKDKEDRCKELVEVEDRCTNFKLELYLKGLSTEFEKDKESDYFSWGQVSKLVSREDCIKFESECFHLEGVCTNKIGKACENVRVACYKKGQDRVLNRYFQEGLKGLIGDLELVTENLEKCQKSVVGNYTKLKEDRRYFTKCHLPTKLCYELLDDVILQSEELEVVLNLRRDFPRKEDCVELKKKCKDLESDSYLNHEKCDTLNRRCEYLKVTEELRKRLLKRGDDALRTQGNCTAVLKKECEELSRRGKEDFSVSCALREETCSFMVEQTENECLFLKNNIENGKILNKIENGKGNETLVEELCTLFDPYCHQYIENCPDRLKKEKNSNKNGVCLQLEEKCKPFFEKLKLENELTHKLKGSLSDETKCKETLGKHCTEWKKEGNQTLNSLCEDAKKEELCKKLVKKVKEKCPTLKNKLDNEKDELEKKKDEYEKAKQESEKFAKEAKLVLSRPEQDGQGGGSKAQDGSVPKPVGPPVQPPAPAQPTPGGVPAPTLAPPAQPTSGGAPLPVPPAAPGGTPGGAPVPVPPPAPGTPPAGPAGPSGPSGGTPAGPPAPGGSTPSGTTNTSNVILVRRTFVSGEVSEPEKKAFVATARALELYLELKEKCKGLKGDCEFRKDCPKCEAVCTEIDKLCEGIEGLKVTPHHTVISTATQTTTTTATTTTTTTTTTTTTTTTTTTATTTESVDGGKVTEECTLVQTTDTWVTSTSLHTSTLTSTSTVTSTVTLTSMRKCKPTRCTSDSSKETETQKEEEKEEEVKPNEGMKIRVPEMIKIMLLGVIVMGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNX8</accession>
    <name>M7NNX8_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875016.1">
        <property type="nucleotide sequence ID" value="XM_007876825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNX8"/>
    <dbReference type="STRING" id="1069680.M7NNX8"/>
    <dbReference type="GeneID" id="19896657"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02970"/>
    <dbReference type="eggNOG" id="KOG0789">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001645_9_1_1"/>
    <dbReference type="OMA" id="GHKWWIA"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18533">
        <property type="entry name" value="PTP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="192"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="288" mass="34097" checksum="080201120BDB5273" modified="2013-05-29" version="1">MDLSYDALHEKFAQLQILEKQRKKSLASEWSVTESQKKKNLSRNRYSDIVPYNKSRVKLINSENDYINASYIFLPNDKKYIASQGPLKSTILHFWNMVWDNLEDQGIILMLTKIEEQGLEKCAKYWPEEEKEFIFPEVFLKVEFIGKEYDEKAETLIHHLKLSRLNKPELSKYINHFYFKNWPDHGIPQNLLPFINLISLVTLIKKKNDYIIVHCSAGCGRTGTYIALDYLISTLSTFKVNFNENINEDPIFNIINQIREQRMHMVQSFSQLEFIYKTVKYFLKTLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP83</accession>
    <name>M7NP83_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Disintegrin and metalloproteinase domain-containing protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02698</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Probable zinc protease.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874722.1">
        <property type="nucleotide sequence ID" value="XM_007876531.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP83"/>
    <dbReference type="STRING" id="1069680.M7NP83"/>
    <dbReference type="GeneID" id="19896389"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02698"/>
    <dbReference type="eggNOG" id="KOG3607">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012383_1_0_1"/>
    <dbReference type="OMA" id="WNADCSA"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000003">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082179" description="Disintegrin and metalloproteinase domain-containing protein B" evidence="6">
        <location>
            <begin position="20"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="688"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="8">
        <location>
            <begin position="273"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="7">
        <location>
            <begin position="507"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00056552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00074021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="778" mass="88474" checksum="7D897B43B639C4A8" modified="2013-05-29" version="1">MRYLFSYILLYPFLKGIHASLITQQVNIHEVFPLKDVVLYPHETSKKSIDSHSSFDLTFTLPYHYQQTEYPDWMKKYVKLTMVPNLDLLSEDSYLKIHNEDGEVISSERIDRNNYRVYRGDAFITYTENNTGLLEKKWHKIGWARISLHQDGDLPIFEGAFSLSNDFYTVKTAENYMLLKEAHEPEIFEPKKSMVLWRESNKPPKTLRKRSNIYLDNKCLLNSLYDDMVPINLAALSSNSRKSNAAEKSSLFSSRIRLAEYIGDNSGCPKYKQIAYVGAALDCNYISMFQSSIDATNHVIHLYNRVSLIYEETFNISLGLLNITIMNRSCPKENPKVLWNVACSLQHNISTRLKHFSLWRTQIKDNIALWSLFTTCRNTMEVGIAWYGVLCQDIISKNQDINWVSGTNVIASPKNIEHVVLAHEIGHGFGASHDCTSETCKNESASCCPLSTTICNANEMYIMNPKSSITARTFSQCTIGQVCNNLKKKHVNSNCLVNNKNVSLISQKKCGNGIVEDGEDCDCGGEEGCKGNLCCNPKTCKFTRGSECDDSNEVCCIKCRYAPKNTICRSSRGECDLVEVCSGTSSICPRDKFKKDGTPCGNKSKCASGICTTRDMQCINHFNNSKGSCHSSCVLFCELGGVCIYSGFQSYFIDGTPCGFYGYCYKGNCIEGSYGKHLKSLLSGLKNWIFIIIFILGLVLAFLINCIFSRCFSHVSQKEKVIDQDYQTDHIPIYTNYPYNYDNIPNYIPHMQYNPHRHYHNFNERNFYYEANPNLPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPC6</accession>
    <name>M7NPC6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 2 subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01269</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF2B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873192.1">
        <property type="nucleotide sequence ID" value="XM_007875001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPC6"/>
    <dbReference type="STRING" id="1069680.M7NPC6"/>
    <dbReference type="GeneID" id="19894966"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01269"/>
    <dbReference type="eggNOG" id="KOG2916">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033458_0_1_1"/>
    <dbReference type="OMA" id="DVNEHQR"/>
    <dbReference type="OrthoDB" id="1685042at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990856">
        <property type="term" value="F:methionyl-initiator methionine tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1130:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000015">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.190:FF:000002">
        <property type="entry name" value="Translation initiation factor 2, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="10">
        <location>
            <begin position="17"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR10563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="304" mass="34780" checksum="B1C21DE759C0080A" modified="2013-05-29" version="1">MSTTSCRFYENKYPDVDELVMVNVKQIQEMGAYVQLLEYNNIEGMILLSELSRRRIRSVQKLIRVGRNEVVVVLRVDKEKGYIDLSKRRVSPEDIIKCEDKFNKSKTVHSILRNVTEKHSIPLEELYMSIGWPLYRKYGHAYDAFKFAIVDSNSVFEGLTPSNPQIIDDLITQITRRLTLQAVKIRADVEVSCFEYEGIDAVKRALKAAEAKNSKDALIKVKLIAPPLYVIITSALDKKLGIQILEEALEEIEKSITASGGEFVVKMKPKDVNEVDELELQALMQRMEWENAEKSGDEDESDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPF9</accession>
    <name>M7NPF9_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_02756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874787.1">
        <property type="nucleotide sequence ID" value="XM_007876596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPF9"/>
    <dbReference type="GeneID" id="19896447"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02756"/>
    <dbReference type="HOGENOM" id="CLU_600082_0_0_1"/>
    <dbReference type="OrthoDB" id="5423432at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="456" mass="53166" checksum="338E862AB3C6DB79" modified="2013-05-29" version="1">MMQMFLLKKGIKLYFLKIYYFLFYYIRSSGDVEMFTSIKDYKSFYASDMMTFDPYNTASFIPEFRNNVINIDNNDDNISRTFTKYGIAHIFNDDVNDNCEANSARIVHGKSIAIENVKPKTSQEFAEEMYYKRKIRTSLREKKCESAFENRNNTLLESSLDRIKPLNLNSSDLIRNAKKNTINEIKTWEMDMKYNNMPSIIDDNKNVEGFRDLKNTIISGDSRDRIKTILKLEVSRKDVPIEHKEEYISEYDNKYDRNSSSYSRLKNVDGEFDSMYFLSNSRQVSSSRYHNLDSNQTSRFSTFFASDSINLISDVKKNNLNVSSNNEPLSTEYSDTGLIYGSDYNDKFSEISITTSKTSDEIGFQRIMDMLRKSNQSISTNRLISHNSKITSNEIDYNKSNEYSIQNSDNLLKYQSFMHKDISDSKFFLSLLNQPSHLSSLHVDSLNNENINAFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPH1</accession>
    <name>M7NPH1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874802.1">
        <property type="nucleotide sequence ID" value="XM_007876611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPH1"/>
    <dbReference type="STRING" id="1069680.M7NPH1"/>
    <dbReference type="MEROPS" id="A28.A06"/>
    <dbReference type="GeneID" id="19896461"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02772"/>
    <dbReference type="eggNOG" id="KOG0012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020435_2_0_1"/>
    <dbReference type="OMA" id="NTHTRHP"/>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05479">
        <property type="entry name" value="RP_DDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14309">
        <property type="entry name" value="UBA_scDdi1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057273">
        <property type="entry name" value="Ddi1/2_HDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019103">
        <property type="entry name" value="Peptidase_aspartic_DDI1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15397:SF3">
        <property type="entry name" value="DNA DAMAGE INDUCIBLE 1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15397">
        <property type="entry name" value="SODIUM-GLUCOSE COTRANSPORTER REGULATORY PROTEIN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09668">
        <property type="entry name" value="Asp_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24669">
        <property type="entry name" value="Ddi2_HDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="1">
        <location>
            <begin position="282"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="320" mass="36028" checksum="544747216962A71F" modified="2013-05-29" version="1" fragment="single">MWNSLDPEILRLRLLSRPQFLEIIQQTHPELAEAAVHNPEEFKRIVQSMYFDRNYLEIQRQREISALNADPLNIEAQARIEEIIRQEAVMENLENAMEYHPESFGRVTMLYIDVEINKYKAKAFVDSGAQNTIMSPSCAKACGITHLIDKRFFGVAKGVGTANIIGRVHSAQIKVGPLFLACSFTIIEGKDIDILFGLDMLRSHQACIDLKRNALVINDTLIPFLSEAELPDSAKMETIYVPETINHDSEQTKANNTQKQLGSLDNSNILDQSAYKGQSESKYHEKDIRQLQALGFSKEEALQALEAANGDVSIAANFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPL9</accession>
    <name>M7NPL9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase I subunit RPA49</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01352</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873282.1">
        <property type="nucleotide sequence ID" value="XM_007875091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPL9"/>
    <dbReference type="STRING" id="1069680.M7NPL9"/>
    <dbReference type="GeneID" id="19895049"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01352"/>
    <dbReference type="eggNOG" id="KOG4183">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034953_2_1_1"/>
    <dbReference type="OMA" id="DVYPFDE"/>
    <dbReference type="OrthoDB" id="532500at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009668">
        <property type="entry name" value="RNA_pol-assoc_fac_A49-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14440">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06870">
        <property type="entry name" value="RNA_pol_I_A49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="47021" checksum="16AFCAF803BB0937" modified="2013-05-29" version="1">MTDLSFKKIRLHSVQNVPGPILISSPGFLPDQKTHFTVSREEKSNEWIVEGDSGGIRYHGSTANKRGDSFFQYCIAVENQENDTFDMIPVPLIHLKCHVKSQKIHEDIEKNIEKKDYEKEKKELGETFGSKKMKKIIQNKAFNIIDTQQFEDISSHMINDVKEVTKNMSSLEEIHANTYPNLPIPPPNTQATKLEEVYSLSDIVTEPELLAIHVKAILQEQNERNRTLLLPFKNSRYVNEHLSKALKAEKKNKRHIKLLYYVSLLMAFYTNRHLVSKKELLIKKLGDLPLILIDHLITRFSEYIRSGTNYETIQSVITSHGMDKILCYLFALCLIIDNFSVDINLLAQDLSLSTQKCKGLFKTLGCKIQGCTEAQRLAMNLSKAEVKLYKRAVLTLPFEIVSKKQRKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPM0</accession>
    <name>M7NPM0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor Pcc1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02539</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874552.1">
        <property type="nucleotide sequence ID" value="XM_007876361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPM0"/>
    <dbReference type="STRING" id="1069680.M7NPM0"/>
    <dbReference type="GeneID" id="19896231"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02539"/>
    <dbReference type="OMA" id="KHLVYRE"/>
    <dbReference type="OrthoDB" id="10025739at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000005">
        <property type="entry name" value="L antigen family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283">
        <property type="entry name" value="EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283:SF5">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT LAGE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="10140" checksum="2B5168FC12E3F78F" modified="2013-05-29" version="1">MSQSFIKFDHIIDISIPFPTEQLASQVAAVLSVDLELKKHLVYREIRVDGLYFSVVFQSNDLKVLRVSVDSFLDNIILIIRTVNECGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPN7</accession>
    <name>M7NPN7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase II-associated protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02553</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the RPAP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874566.1">
        <property type="nucleotide sequence ID" value="XM_007876375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPN7"/>
    <dbReference type="STRING" id="1069680.M7NPN7"/>
    <dbReference type="GeneID" id="19896245"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02553"/>
    <dbReference type="eggNOG" id="KOG4151">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_918968_0_0_1"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051966">
        <property type="entry name" value="RPAP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025986">
        <property type="entry name" value="RPAP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46423">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46423:SF1">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13877">
        <property type="entry name" value="RPAP3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="71"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-polymerase II-associated protein 3-like C-terminal" evidence="6">
        <location>
            <begin position="183"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="309" mass="36115" checksum="98276A8113871CC1" modified="2013-05-29" version="1">MAQLTGKIQADAAYLKGDFEAAEALYTQALLEAPDDERLWTNRAQTYLQLKRWSEAINDCSEALKRNPYNLKALFRRGKAYEQQGNIKAAKEDWNLALIQDPKNKTVQEALFLLNKTKINCTDEKVEKVVKKIPIAIKEVETLPSWAENEYQHNSNTKEYKPSLNGLKYKTSTKEVIPTLQILEQKLRTMEETEISKQEKLMYFFSINYVMLPHLFGTAGLEGIFLETFLHAIKYAYQQEKDKIKWWKQSLGILQQLSCCSRFDIAILFVKKTILEDMNQLFEKAIIEMEEKIKESYRTIWEIWMNQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPR9</accession>
    <name>M7NPR9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02445</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874453.1">
        <property type="nucleotide sequence ID" value="XM_007876262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPR9"/>
    <dbReference type="STRING" id="1069680.M7NPR9"/>
    <dbReference type="GeneID" id="19896138"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02445"/>
    <dbReference type="eggNOG" id="ENOG502RZ32">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069841_2_0_1"/>
    <dbReference type="OrthoDB" id="19092at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="110"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="239" mass="28293" checksum="724D415E82C2260E" modified="2013-05-29" version="1">MKIKSNKKSLGNLYEKRQSLPSKWLQTDIFGTIYRDYAYSCDDPRFYKSPLEYDFLKSTLNSCMRFSFTDDDLDFDQDLLLKDDYFQSTFENEQFNDIESYKVLETSADEIYGKAVALFDFIPEHENEFALVRGQKIWISYRHGQGWLVAVDPETGDTGLVPEEYVQMYDFDDVFSDNKKQYISIKQSEETILENDVQKDKINDNYDSSRNSDMDDVMKNETYSLDEQYSRLSLYEENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPU5</accession>
    <name>M7NPU5_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_02474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874483.1">
        <property type="nucleotide sequence ID" value="XM_007876292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPU5"/>
    <dbReference type="STRING" id="1069680.M7NPU5"/>
    <dbReference type="GeneID" id="19896167"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02474"/>
    <dbReference type="eggNOG" id="ENOG502SDNM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139293_0_0_1"/>
    <dbReference type="OMA" id="KSMGLCL"/>
    <dbReference type="OrthoDB" id="4392610at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR09131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="125" mass="14877" checksum="9C062291DBD7C33A" modified="2013-05-29" version="1">MNSAQVRRLYRQFLRIGCQAVCNSIPAKYIIRDKIRAAFRILPPPTEKIVNTLQFLIRASKRKGLEHAILKNLCYLDQSKKLYVKRRRKPLSMMKEEEMFLYKRVYDESDLTIYMINETCGLCLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ18</accession>
    <name>M7NQ18_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Peroxin/Ferlin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00936</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872848.1">
        <property type="nucleotide sequence ID" value="XM_007874657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ18"/>
    <dbReference type="STRING" id="1069680.M7NQ18"/>
    <dbReference type="GeneID" id="19894634"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00936"/>
    <dbReference type="eggNOG" id="ENOG502QT80">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016397_0_1_1"/>
    <dbReference type="OMA" id="PPFYILT"/>
    <dbReference type="OrthoDB" id="5586090at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052646">
        <property type="entry name" value="Peroxisomal_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00694">
        <property type="entry name" value="DysFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00693">
        <property type="entry name" value="DysFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxin/Ferlin" evidence="6">
        <location>
            <begin position="267"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxin/Ferlin" evidence="7">
        <location>
            <begin position="358"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="432" mass="51205" checksum="5011C446B06CBA98" modified="2013-05-29" version="1">MATINSDWVNDVVLPAKKKLIYATFSKDTPLESSSTSSSLNKVNLFASTPPSVIRSIIFVRPLLEWTNWILSLLTWTSNDPWNSFLLVICWWIFVFNIETLIIFGPLVVIFIMAFLYIKKRKDLKLEQNKIYTQNDLDIFIQQTDFFKERVSILTSSINEIRTFLNWSSPQLSVTIVIRLLFISPFWIAMLLFLVTPRQMIFTIVTIIFIWHAPWIKGTRLILWRSRLVRIIVGEVVGINFIPRENKIIQGFSEKKIQNELEVSDETVKYTFILWENQRKWIGFGWTCSMFPHERTPWTDEDGYPSTSPDAFLLPKDKIIIRINSETGSKEKYRTYWEWIDKSWVIEHSDLGDKDSDGWIYTDNLWKKESLKDDFRKYTRRRKWIRNAELLEVIHEMKNDVEVEKNDITKKSFDNNDNISETRLKNTDLDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ66</accession>
    <name>M7NQ66_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase II degradation factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PNEG_00994</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872908.1">
        <property type="nucleotide sequence ID" value="XM_007874717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ66"/>
    <dbReference type="STRING" id="1069680.M7NQ66"/>
    <dbReference type="GeneID" id="19894692"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00994"/>
    <dbReference type="eggNOG" id="ENOG502S359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_325742_0_0_1"/>
    <dbReference type="OrthoDB" id="5396806at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14368">
        <property type="entry name" value="CUE_DEF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041803">
        <property type="entry name" value="DEF1_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051833">
        <property type="entry name" value="TC-DDR_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308:SF13">
        <property type="entry name" value="PROTEIN LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308">
        <property type="entry name" value="UBIQUITIN ASSOCIATED PROTEIN 2-LIKE/LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="CUE" evidence="17">
        <location>
            <begin position="65"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="114"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="497"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="725"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="813"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="725"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="761"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="835"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMR10848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="885" mass="100343" checksum="AAFAEC544E7CCFDF" modified="2013-05-29" version="1">MTEVQQLQKKQSRKEFRQTHPRRSHNHGTQETYKTQVSMEKSSQENPEETSTNPLSLESAMLKTRYHRQLLSCKELFPDWTEDDILYAIQEASGDFELAVTRISEGRADKWGEVKKRTKDKGKKQDALHSSTSLVGGGKNFRDKIRDPKNVKNKENFPKSGGGRSNGISKRNHQTLSDSSLVVWDTVKNAESRTVSIDTTGTASNIKSSWTSYQQSRDSLEQCLDVKKDINKTIEYDIKETENSIWEDFNPINQDSGSISAWSDAATKASSVTAGWGESGSFYMSNAESQNSSSSKLRTKVISPGMNPSWASLLKQESIPDMQEQQLSPISRTSFRSDENFTNTFTISKLTEKKDHEIINGLNHVPIVSKTPLTALNLESINKENIEHVVSLKKPKNSINIANQSLNNTARFHEFNKSHSSKSTYHRHLSQDAPVVMPNLTNISERVEVQFGSLNISDQENGLFLNREKSKPELNSVSQGISMNLHSPIGPALQPPQSIGNSESTDLQKTQKIYPESSNTTQQPHLLPNRTTMFPSNLNKTNQQLSEQKQVQFQPFDQDSYNNYTNHPIRDHVPNFGNFSLPNEYQRFYGSEDSRPHFTQGYYDPSAFSCGQPSNTSIHRDASNINNEYIQTSRFDPNALEGSSIPSQQVASGPIVHKQVPMGPNTLSQSHSSTQGHFHQAQTYPIHPYYNPYTAYYVNQYGYGNYPYTKQNIYNHLQQDYSRSYNENSFTNSDTTKKFNGHRRDLSQSTNQGNPQDYPASKSQNSNTSQQQQWSQQKNISNNSLDYTGEKLNTTTHQSNYIQHMQKFHQQNPVRPIYPGSSHTFPPYLQQPLHPQASSTQSSSTQAQPSPYSMHPHAIGFHGPYQPMLNRQDHPNLNWTNYTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQL5</accession>
    <name>M7NQL5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sphingolipid delta(4)-desaturase</fullName>
            <ecNumber evidence="8">1.14.19.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_00618</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Delta(4)-fatty-acid desaturase which introduces a double bond at the 4-position in the long-chain base (LCB) of ceramides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = an N-acylsphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:46544"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:31488"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="1.14.19.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.17" evidence="8"/>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872516.1">
        <property type="nucleotide sequence ID" value="XM_007874325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQL5"/>
    <dbReference type="STRING" id="1069680.M7NQL5"/>
    <dbReference type="GeneID" id="19894316"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00618"/>
    <dbReference type="eggNOG" id="KOG2987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032156_0_1_1"/>
    <dbReference type="OMA" id="GATCNQN"/>
    <dbReference type="OrthoDB" id="200948at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042284">
        <property type="term" value="F:sphingolipid delta-4 desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03508">
        <property type="entry name" value="Delta4-sphingolipid-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011388">
        <property type="entry name" value="DES1/DES2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013866">
        <property type="entry name" value="Sphingolipid_d4-desaturase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879">
        <property type="entry name" value="SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879:SF8">
        <property type="entry name" value="SPHINGOLIPID DELTA(4)-DESATURASE DES1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08557">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017228">
        <property type="entry name" value="Sphnglp_dlt4_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01269">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingolipid delta4-desaturase N-terminal" evidence="10">
        <location>
            <begin position="9"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR11018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="331" mass="39049" checksum="2ED4B53EB7E49C36" modified="2013-05-29" version="1">MSIEKNKKNNLNDFLWTFQEEPHKTRRKEIIKAHPEVIKLCGHEPLTKYIICTVVLFQLVSAYLLRNENWMSLKFLLYVYFFGATANHNIFLSIHELSHNLVFKNAKLNQYFSIFANLPIGLPYSASFKPYHLLHHKYLGEDGTDTDLPTKLEVILFNNVLGKAFFCTFQIFFYSLRPIFLKRLPFTSLHIYNLLIQLLFDIILIRLAGSGALFYLIFSSFLAGSLHPCAGHFIAEHFSIIKNTNETIDTYSYYGILNILTYNVGYHNEHHDFPFIPWSRLPKLNNIANEFYRNIPYHTSWIYVMWQFITDDRVGLWCRIKRRNKLTLISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQW3</accession>
    <name>M7NQW3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="9">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_02089</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="9"/>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874069.1">
        <property type="nucleotide sequence ID" value="XM_007875878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQW3"/>
    <dbReference type="STRING" id="1069680.M7NQW3"/>
    <dbReference type="GeneID" id="19895783"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02089"/>
    <dbReference type="eggNOG" id="KOG2867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030733_3_1_1"/>
    <dbReference type="OMA" id="DACHISP"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016325">
        <property type="entry name" value="Phstyr_phstse_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0697">Rotamase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR09501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="320" mass="37086" checksum="AA3FC336A378B77B" modified="2013-05-29" version="1">MSIQYPSFDTISPEEAFSLGCLKRIDSRNDVFLFQKSIAYSRITDFIKVLNLALPGTKLTDYMNESDEIRKILSVLDVVSSWIEEIPPEKGPKRFGNKAFQKWIDRLENEALVLLKKFLPDWIYPALNELYPYFTGGFGHGKRLDYGTGHELSFTAFLCGLLLLRFFKLDRDEVPIVLRIFNKYFEIIRTLVITYNLEPAGSHGVWGLDDHFFLPYVFGSSQLSCTNVTVLPKDILDKNIVKQQKSENLYFSAISFINDVKHGPFYEHSPYLYDISGIEYWKKVNQGMLKMYYAEVLGKFPVIQHFLFGNILFPFDPVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRE8</accession>
    <name>M7NRE8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Autophagy-related protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PNEG_00327</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATG27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872200.1">
        <property type="nucleotide sequence ID" value="XM_007874009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRE8"/>
    <dbReference type="STRING" id="1069680.M7NRE8"/>
    <dbReference type="GeneID" id="19894025"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00327"/>
    <dbReference type="eggNOG" id="ENOG502RBBE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047751_0_0_1"/>
    <dbReference type="OMA" id="CKGINSE"/>
    <dbReference type="OrthoDB" id="29460at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018939">
        <property type="entry name" value="Autophagy-rel_prot_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09451">
        <property type="entry name" value="ATG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0072">Autophagy</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082229" description="Autophagy-related protein 27" evidence="16">
        <location>
            <begin position="20"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="17">
        <location>
            <begin position="21"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMR11298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="256" mass="30355" checksum="3A63502A15D2C343" modified="2013-05-29" version="1">MSFLILILVISRLCIKVFGLFECYFNLDGFVFNLTGLDYTYYVTNFYRLETEQVNMTWTISLCKGINSEIFGGGGYCKKDSRICSVKKVISGEEERVEEVKGLYFDFDNKYLTDSGFEVIFHNNRVRKSNLSAIIHFICDEEEHNPRLIFYKYSMLWLEWKTNFACKNIETEKKRNDGSIFSFFIWLMIIFFLIILSLVLFHLYFNYRYYGSLEIDLFSYIEMIKNMKYFLKDFTSKAIVYIKSLGNSFQGGYTPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRP7</accession>
    <name>M7NRP7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome c oxidase subunit IV</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_01945</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase IV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873922.1">
        <property type="nucleotide sequence ID" value="XM_007875731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRP7"/>
    <dbReference type="STRING" id="1069680.M7NRP7"/>
    <dbReference type="GeneID" id="19895639"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01945"/>
    <dbReference type="eggNOG" id="KOG4075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070101_2_0_1"/>
    <dbReference type="OMA" id="YVIHLFA"/>
    <dbReference type="OrthoDB" id="186013at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00922">
        <property type="entry name" value="Cyt_c_Oxidase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.442.10">
        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004203">
        <property type="entry name" value="Cyt_c_oxidase_su4_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036639">
        <property type="entry name" value="Cyt_c_oxidase_su4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707:SF10">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02936">
        <property type="entry name" value="COX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81406">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR09761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13738" checksum="CCCF91A5D2409438" modified="2013-05-29" version="1">MSSDEKIDIQRQLNERQRGPWHDLTKEEKKAAYFIAFGPYGSRSTIHPPGFFKKVVIGTLSMLTISTILFFTVRSFAASPPHTMTKEWQEASNELLKTQNIEPITGISSKGYKGKGMVQSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRQ9</accession>
    <name>M7NRQ9_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01725</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873689.1">
        <property type="nucleotide sequence ID" value="XM_007875498.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NRQ9"/>
    <dbReference type="GeneID" id="19895419"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01725"/>
    <dbReference type="eggNOG" id="KOG4674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_237445_0_0_1"/>
    <dbReference type="OMA" id="HAQQNYE"/>
    <dbReference type="OrthoDB" id="343070at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057974">
        <property type="entry name" value="NUA/TPR/MLP1-2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012929">
        <property type="entry name" value="Nucleoprot-TPR/MLP1-2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898:SF2">
        <property type="entry name" value="NUCLEOPROTEIN TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898">
        <property type="entry name" value="NUCLEOPROTEIN TPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25785">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07926">
        <property type="entry name" value="TPR_MLP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUA/TPR/MLP1-2-like" evidence="7">
        <location>
            <begin position="484"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoprotein TPR/MLP1-2" evidence="6">
        <location>
            <begin position="1041"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1827"/>
            <end position="1848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1865"/>
            <end position="1936"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="58"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="128"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="474"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="562"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="661"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="897"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="990"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1288"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1508"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1634"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1723"/>
            <end position="1772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1829"/>
            <end position="1840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1867"/>
            <end position="1884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1936" mass="227427" checksum="32492D24B97136FE" modified="2013-05-29" version="1">MALVESAVDVGRISSFLDLSSDFITNLGSKEEITLLLSGILQKANEFEELKKSKVILEVNYEQETHAANRRLQSIKNELETSLEDNKYLKEQSTLYKTTSEKLETEIAGLRSSNTDLKEYIHTLESRNRFLESEKREVVEVLERKTQEILRQEEEYQNLTERYGKLRKEINSIESENHELKDKEISWKFKEQTSLQEIELLKKNIEWLNREVEDKTNEFSEYRKDKSSQISTLQLELENTVSASTIHENNANTSKKQLEKMSNKLEETLFKLKECQDKIVEQEESFRNEMDVQHRLTELLEQNLKNSRQRITELEEHLDEDSTKEGQEALKWMNIAEKEKNRADSMELQLEELELKAEKLQVELVVAKDQLSQGISNENAPLGIGLLSPSAQAANKLEKSGMSLTKLYSEYISLKEQLKSEKKHNEIMQNNLNDLLSDLETRAPQIHEQREEFSRLQVEIADISGMLQESNELKEKIDRENKILKIHIKDLEQEKLLYLQQTRDLSRQIQCLLYEMEIQNYTGVIMTEEEKSVIKKISESDIIEPTDTHFLISERLTLFKDIKTLQEQNQNLLKVIRELGTRMEKEELENRERLENLESAAITEANNVIEDMKEEMKKLKIKMDSYIRERDMFRRMLVYNGQTDPLSSSDLETNESDTISAIKSQNALRELQIQFDQYRNETSINNKTLSQQLRDATNHNSNLQIQLAKMTSQLELFSERYNMLSENADILKNERDNIGLRNQQMQETLAKQDLKLLHLSEEVVEFKSTIDNLRTETANLKAEKQLWKNIEMRLTSDNENLTLEKNRLNKLLSDLQAILNEKERIDSESRRRLIEQNELIEKELQQIRHKATEENEEYKKLMIRKEHEFLEYQSKINNLTTKYSETYENLLVAQTTQQNLQSKVDELSILLKSTEEKLLVYQKNTTETLENESLSKEQQLEIEIMNLRSSLDIAKSEAEQAKKYADQMKLISHAAEETLQDMNNIHDEYKAAVEKLLFDKENDIKELTQKIKIISEELETRKIELLQFETSQNEQRENFDNEKKELIAKIEKLEEIEKLSIKAQNDYKEDLRKQFQISQEARSSYERELVSHAETTNNLQLLRQENSDLKTEILTLNKDNESFKFQLSTSENSWKTLKENYEKELQDIKTRCNELVQQNNLLHNQFENISLQALKLQKVANQDDIHDLSDTVTCDKSTEDLKEIVRFLRREKEIVDCQYELSIQENKRIKHELSKTLKSLDDVRLTLNSERQQKNDLINSTSQYQDLMSKINELNILRESNTVLRTENKINVEKLKEYEKSIQNLTSQIQPLEDQLRMLQAEQEVKESQLKLTQEDNERWKNRVQQILQKHGQTDPDELKNIKDKFVLLEKENSKILQEHQNAKEEIEKLNLQNTNLANAWKTKYDRLIAQSKEKIQTIRSQILQKTQELEIKTKSEEELKKQIAQLQEIISKDQRVNVQEKNKANKSENSIVSFENEKIKWEVEKKSFQDKFQEEIQLKEKMYAEKVAELEKVKETSDQETKKLKAKALIFFREKNSALEELKKANTQLSKLQDTVQLLKDSNTEELIKKKVEERLSELEKNKNDEIELQVNNRIKELQKGLENKGEKTTQDIKLDENFPKNLNNHNIETIIYSRIEKEKEQWKEDHKQALLAKEDELKKIHEEKLKTFIEQTKKNSNTTLRANPMKEQIEKILSKRLSTELSKAQSKWENETQTKIKDALEKQELQLKNKHTQDIENLRKENEMRNKLKLSEAEKQISDLKNKIILLESKKTESSQNLTEKSNDNLKEHTETKPDLMGFIIQHFPQKSEIVSKDPKKQMKLEYIQKDTPSQTDQSIPLQTDKPLEPNIESNISVSTTNIQTPKEISNTSDNISDNSTSHNTIAPSKPLSATAAKFVPTKRIREEEGSVISETPPTNLRKRKINENPDLNVEKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NS76</accession>
    <name>M7NS76_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00049</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871903.1">
        <property type="nucleotide sequence ID" value="XM_007873712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NS76"/>
    <dbReference type="STRING" id="1069680.M7NS76"/>
    <dbReference type="GeneID" id="19893747"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00049"/>
    <dbReference type="eggNOG" id="KOG2710">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_527976_0_0_1"/>
    <dbReference type="OrthoDB" id="3196451at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF25">
        <property type="entry name" value="F-BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="60"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="489"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR11608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="516" mass="58887" checksum="9955A442B8D87A3A" modified="2013-05-29" version="1">MQEKGQKLNEAITLSQKLSLFLSWRQFKEKQGWKKLVTEKTKGIFGVPLQISLRYANVAISFVDNNENSMIYGHIPVVVAKCGAFLKENAKDVKGIFRLNGSAKRCKELQTIFDTPPKYGRNLEWDGFTVHDAASILRRYLNYLPEPIIPHKFYEPFRKPLKNESYNKEEYISIYKRLIASLPPINRQLLLYILDLLAVFASKSKENLMTVSNLSSIFQPGILSHPEHDMSPKDYFLSQKVLIFLVDNQDHFFTNTAGIDSDLVISLTRCRDNDILERASTINSLKFASRKKHNVLKKIPHVSSKSLSFHKNKHSKSMDFNLKKSFRFLLRSNVLPNKSQCIEIDSHVIQDLVSPKKLKTLKNSKFPSRKLSIDNNTFYNKIKRRNSYSSMGTSTEDIHIYSTSRTSKNTKSKSFIYTFSSSLVDAIRPLKFQNKSLYKTIPINLSSSSLKTIGTCSNTSPLKLEAHRSSQSIHSAHSRTISIPSSLASEDKFSRDSSIFTKKAPRKDSSGDAQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSX9</accession>
    <name>M7NSX9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Potassium transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01488</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873428.1">
        <property type="nucleotide sequence ID" value="XM_007875237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSX9"/>
    <dbReference type="STRING" id="1069680.M7NSX9"/>
    <dbReference type="GeneID" id="19895184"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01488"/>
    <dbReference type="eggNOG" id="KOG1341">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005947_0_1_1"/>
    <dbReference type="OMA" id="WESANEN"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032178">
        <property type="term" value="C:medial membrane band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031520">
        <property type="term" value="C:plasma membrane of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004773">
        <property type="entry name" value="K/Na_transp_Trk1/HKT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00934">
        <property type="entry name" value="2a38euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF30">
        <property type="entry name" value="HIGH-AFFINITY POTASSIUM TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 10" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="461"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="645"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="669"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR002450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR10216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="761" mass="87267" checksum="4BEC3A0B725F2E16" modified="2013-05-29" version="1">MMGGTIEKLKTSQVVVPKINFLRLHYIYILSAILISTFLIYIPKNIKFVDALFLGCSAATQAGLATLDIDTLSTYQQVILYVVSILTTSIFIHSLTAVVRFFLIRSKFDNIVQQARSQSLRRNQNLSHPFLSYSEIEERGVGDRAIHVLLRWESANENEFHPTPLRRTSISFGNANSQPKLQDHERKNEVHRYLEGSSCLNNTSNSNNSIHKEDNTDIKLQKSESIIPREERQVSSDIRFGDLPVPVRQSIDVTKDNELHIVQEPFEQENEFNNKLRKSKSVEPQSVSATNEPLTPITRLPTYDNNYYLRMRKSTTADRSISKVSTFDRYISNTFWKKRDSSPLSQRTSKSFPYLSYQPTIGRNSAFVTLTKEQRDELGGIEYRALKLLCWILVCYYLIFHSFAAILFLIFSIYAKSYHKAINEASESSVWWAFFTSASLFNNFGMALNPTSLIEYRQSKFILIFGSFLIVAGNTAFPILLRFFIWLITFILPKDSLHKESLHFLLDHPRRCFILLFPSKVTMWLFALLVMLSITDAILFMVLDFNNPSLAEIGPIYLKILNSLFQSFSTRTAGFTVVNLLTLHTAVLVSYMFMMYISVFPVAVSIRKTNVYEERSLGIYTIDDDSAQNSSFVGTHIKHQLSFDLWYIFLGLFIICIVENTNIKDESLPNFSVFSILFEIISAYCTVGLSLGHSDIDSSFSSKLSTISKLVIISLQIRGRHRGLPYALDRAVLLPTEKMERVEEEDYRRKTRGPIINNENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSY4</accession>
    <name>M7NSY4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pru domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01107</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873022.1">
        <property type="nucleotide sequence ID" value="XM_007874831.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSY4"/>
    <dbReference type="STRING" id="1069680.M7NSY4"/>
    <dbReference type="GeneID" id="19894804"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01107"/>
    <dbReference type="eggNOG" id="KOG3037">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041798_0_0_1"/>
    <dbReference type="OMA" id="PTFAKQP"/>
    <dbReference type="OrthoDB" id="340431at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13314">
        <property type="entry name" value="PH_Rpn13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.70:FF:000001">
        <property type="entry name" value="Proteasomal ubiquitin receptor ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.70">
        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038633">
        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038108">
        <property type="entry name" value="RPN13_DEUBAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pru" evidence="6">
        <location>
            <begin position="15"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="319" mass="37125" checksum="E8257ED6C7E47E39" modified="2013-05-29" version="1">MSSMTTSFSEKTKDLKEEYIVKFKAGKMIRDGTTNIVKPDTRKGMIFIRIENDDLLHFYWKDRTTNIIEEDLIIFPGEAEFSCVKDSPSGRVFALHFKSSFQIFFFWMQDLNSNKDDYYVNKINEAIKNPVISESNEYNESPNVNDTQFFDNENDKCVKIASLDSGKENMETKEQNTLPSMTCKNRFSLSEYFLSLKSFLSNVHIPDDFPKESFILTDILTPSEAINLLQNKFIREALFPNLPPDILQNFELDEKSLENIISRECFQQSLRSLNYIISIGKLDAFISKFASDNFRKLDVFFRVIMSLIETIDQEMNISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NT68</accession>
    <name>M7NT68_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal peptidase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01527</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface. Essential for viability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPCS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873471.1">
        <property type="nucleotide sequence ID" value="XM_007875280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NT68"/>
    <dbReference type="STRING" id="1069680.M7NT68"/>
    <dbReference type="GeneID" id="19895222"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01527"/>
    <dbReference type="eggNOG" id="KOG3372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068714_2_1_1"/>
    <dbReference type="OMA" id="WVGALTW"/>
    <dbReference type="OrthoDB" id="10261524at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007653">
        <property type="entry name" value="SPC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 23 KD SUBUNIT SPC22/23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04573">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016089">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR10261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="179" mass="21141" checksum="1C6E3E5F50F63318" modified="2013-05-29" version="1">MYSTIQRLNTLSSLWINALFFLCLWITVSTYFDKKYATSNVNLISAQRKIARISYSFRNIKQEYAFVRFELDTDITPLFHWNTKQVFIYVVASYVSSKNYPYNEIILWTRTIRRKKDAIIHIRNQQNVYSFNDIEGSFMNKNLTLSMYYNIMPQVGILKWGNGSPSGRLPFSVLNEILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUA7</accession>
    <name>M7NUA7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exoribonuclease phosphorolytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01019</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872932.1">
        <property type="nucleotide sequence ID" value="XM_007874741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUA7"/>
    <dbReference type="STRING" id="1069680.M7NUA7"/>
    <dbReference type="GeneID" id="19894717"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01019"/>
    <dbReference type="eggNOG" id="KOG1069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063514_2_1_1"/>
    <dbReference type="OMA" id="SYKCPAT"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11372">
        <property type="entry name" value="RNase_PH_RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="6">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="219" mass="24516" checksum="74449A363E0DF444" modified="2013-05-29" version="1">MKNILFETSLLDRVEGSCIYQEGSNKVVCSVVGPSDIKTRDDALGEAALDVMIRFDIGMSGAKERQMEQIIWKTISPMIIRTMYPHTLIQVVIQVVSYERSENTASLLAAMLNATCIALIDSGISLLSTFSAVCLAVLLKNKEISIIVNPTLKILNECMSTHVVCYAFPDEKLLSCESIGLFTENEFFEILLKAQDACRNIHYEIKTTITKKIMEENHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUH0</accession>
    <name>M7NUH0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">RNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_00895</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872806.1">
        <property type="nucleotide sequence ID" value="XM_007874615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUH0"/>
    <dbReference type="STRING" id="1069680.M7NUH0"/>
    <dbReference type="GeneID" id="19894593"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00895"/>
    <dbReference type="eggNOG" id="KOG0154">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012131_1_1_1"/>
    <dbReference type="OMA" id="AHPYSFQ"/>
    <dbReference type="OrthoDB" id="29221at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948:SF3">
        <property type="entry name" value="FI21118P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="57"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="13">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="198"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="12">
        <location>
            <begin position="530"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="466"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="507"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR10746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="607" mass="68740" checksum="60D2C7BF8F0EA4E2" modified="2013-05-29" version="1">MNTLNGENQISYEYKCRREEEYRCFGGSQRNERSDRGYHGTSYKKRIYEEGPGEPNIQVIFQGLESHIIEIDIQRAIEERGGQIENVILIRNRETRESRCFAFAKFISLEHSKQFIEANYPFLYIGNHRVKISYSKENKWEEDGWICFSCGINNYPRREVCFKCGIPKQDVTVAGNLTHSAPLVLNDGSQDIATTPSQFLLLRKLDLLTTEELIVKGMAKLQVPIVRVLLIRDRMTRQSWGFAFVEYADVNGSKKALANAMSLTSNKGFTISSKTIELSFIHGGVFVPVYDQKNEFAFKSSKNGQLLAYWDEKGFTSEYCPESQKSKDESNALPGEINVSIGSNATCSDNIVSMKEPSFSTKDASTSLKRGVNTVCEQKKQKKRCDNSSIKMAPHLQKWAVKQQELRTGQVENEKIDEIFSDLNLMACLLCQRKFKSEKEIRQHEKLSELHKKNLTDEDLKAQARQRLKKVSTKKDTEVESLNDSNYRDRAQERRIAFNQPSKPDVPSHNSKKNIINSSPKIPEEPANITKGKGAAILGKMGWTEGMGLGLEGKGISKPLNPEMYQEGAGLGSLGAKLGDNPRPSDYAAYVRSVKDRAKRRYETEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUK0</accession>
    <name>M7NUK0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Methionine aminopeptidase</fullName>
            <ecNumber evidence="9">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_00590</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 9">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="9"/>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR10987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872485.1">
        <property type="nucleotide sequence ID" value="XM_007874294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUK0"/>
    <dbReference type="STRING" id="1069680.M7NUK0"/>
    <dbReference type="GeneID" id="19894288"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00590"/>
    <dbReference type="eggNOG" id="KOG2738">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FYGDHAY"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031615">
        <property type="entry name" value="Zfn-C6H2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15801">
        <property type="entry name" value="zf-C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52013">
        <property type="entry name" value="ZF_C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C6H2-type" evidence="10">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR10987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="344" mass="38568" checksum="C857B13CDB85B9B9" modified="2013-05-29" version="1">MSICKGLDCNKVASALQCPVCLKLGIRGSLFCSQDCFKKNWSFHKSIHGSGNYVSDSSSILLVLTEKCFFSNIVIRTYDPFPNFAYTGTLRACYPLSPRRKIPLHIQLPDYAEDGIPRSEQAQSRSFKAIILTKEEQQGMRKVCKLAREVLDIAAAALRPGITTDEIDEIVHMACIERNSYPSPLNYYNFPKSVCTSVNETICHGIPDKYVLKDGDIVNLDVTLYHGGFHGDLNETYYIGEKAKQDADTVRVVETARECLERAIKVVKPGTLFRDIGSVIENYAKSRNCSTVRTYCGHGINRLFHCFPEIPHYAKNKAVGIAKPGMCFTIEPMISLGVWKDVTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUP2</accession>
    <name>M7NUP2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotide exchange factor Fes1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00625</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FES1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872524.1">
        <property type="nucleotide sequence ID" value="XM_007874333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUP2"/>
    <dbReference type="STRING" id="1069680.M7NUP2"/>
    <dbReference type="GeneID" id="19894323"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00625"/>
    <dbReference type="eggNOG" id="KOG2160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046722_1_0_1"/>
    <dbReference type="OMA" id="VDYGHEK"/>
    <dbReference type="OrthoDB" id="10250458at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013918">
        <property type="entry name" value="Nucleotide_exch_fac_Fes1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF18">
        <property type="entry name" value="HSP70-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08609">
        <property type="entry name" value="Fes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nucleotide exchange factor Fes1" evidence="3">
        <location>
            <begin position="4"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR11027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="294" mass="33935" checksum="5DC71296164B18D1" modified="2013-05-29" version="1">MSSLEKLLDFTTSFHTERSESDLNTFRSNLDPELIDHILGKDDAVLMKEAMSIISNPNQSLENRKIAFENFEMLVENIYNAKNLANMNMWEPLIQQLSSSESIIRMHAASVCGTAVQNNFDSQQHFLNNRGLEKVLVLFNSDDDPHVRLKSFYAIASEVRNNLFALEEFCKFDGWSILVKYLNDNNYTILQRKILFFIWTLLLQDTGVDLVIEHIKLNQLQKILVEIIQRKEIQNNALEEALGSISLLYKKSLVFDTNELIIIKNIIKIIKEKRDFEAISEDSINEISVQFGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVM3</accession>
    <name>M7NVM3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome c oxidase assembly protein COX15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_00371</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2</text>
            <dbReference type="Rhea" id="RHEA:63388"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:61715"/>
            <dbReference type="EC" id="1.17.99.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:63389"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872244.1">
        <property type="nucleotide sequence ID" value="XM_007874053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVM3"/>
    <dbReference type="STRING" id="1069680.M7NVM3"/>
    <dbReference type="GeneID" id="19894069"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00371"/>
    <dbReference type="eggNOG" id="KOG2725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017627_0_1_1"/>
    <dbReference type="OMA" id="AFVCYSW"/>
    <dbReference type="OrthoDB" id="1726137at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120547">
        <property type="term" value="F:heme A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01665">
        <property type="entry name" value="HemeA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023754">
        <property type="entry name" value="HemeA_Synthase_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR11342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="53517" checksum="7DE3B9D182485C2D" modified="2013-05-29" version="1">MSLIKLLRSRNCCLFDSSFSRNWYKNRISKRNNIFFGILSKKQLSLSKIRYFSYKNIENNLFISKENNIQLNKSYIGYWLLGCSSLVFGIVILGGLTRLTESGLSITEWKPITGIFPPLSHEEWVSEFEKYKATPEFKFINQDISLSHYKFIYNMEWGHRLLGRIIGVVFVLPAAYFIIRRKVTPNMAKKLISMGCLLGLQGFIGWWMVKSGLKYENFKENKSIPRVSQYRLAIHLGTALFLYIGMLWAGLDILKENKWASKTNEARSFIFQELNNPHLRILKRMIFTLSGLVFITALSGALVAGLDAGLIYNTFPYMGRSLIPPKSELFPEAYSRNNSKLDLWRKNIFENPVMAQLNHRIFGISTFILTSAIFFYSRRMVFLKTTSINIRNTISTLMATMCIQVILGISTLVHLVPISLATMHQANSLIILTFIIILGNRLSIPNYFLKNHHVFFLSNHFKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NW44</accession>
    <name>M7NW44_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872428.1">
        <property type="nucleotide sequence ID" value="XM_007874237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NW44"/>
    <dbReference type="STRING" id="1069680.M7NW44"/>
    <dbReference type="GeneID" id="19894236"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00538"/>
    <dbReference type="eggNOG" id="ENOG502S59S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080196_0_0_1"/>
    <dbReference type="OMA" id="WASEESC"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20534">
        <property type="entry name" value="CYCLIN_CCNM_CCNQ_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048055">
        <property type="entry name" value="Cyclin-Q_first_cyclin_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="263" mass="30950" checksum="C8D14C50264E57AB" modified="2013-05-29" version="1">MAEDIRIPFYPFFILLSSILRLPEETTMLASIYYHKYYRWLEKVNEDNLLRLLDDYTLAIASLSLASKATEQFRRMREFLIPAYSILNPTKPRLTFPSEIYDSLRDSIVNAELLLLRIVKFDLRIILPFSYLEKALNLTLTTWEAEITESTLHRDACLMNTALGRYARCCIMDAMSDYRLSTLYDPQTLSSACLWYVLRDFKIFPEEKFIPWVISVTGNTQIREDIQDAVDDLIQLDLKRCVRRGSSDLQMNISKRQYYDIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWC9</accession>
    <name>M7NWC9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">WH1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_00465</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872347.1">
        <property type="nucleotide sequence ID" value="XM_007874156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWC9"/>
    <dbReference type="STRING" id="1069680.M7NWC9"/>
    <dbReference type="GeneID" id="19894163"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00465"/>
    <dbReference type="eggNOG" id="KOG3671">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015385_0_0_1"/>
    <dbReference type="OMA" id="NGRMRST"/>
    <dbReference type="OrthoDB" id="8963340at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045010">
        <property type="term" value="P:actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00132">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01205">
        <property type="entry name" value="EVH1_WASP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000281">
        <property type="entry name" value="Actin associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000010">
        <property type="entry name" value="Related to Neural Wiskott-Aldrich syndrome protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011026">
        <property type="entry name" value="WAS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033927">
        <property type="entry name" value="WASPfam_EVH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47912">
        <property type="entry name" value="Wiscott-Aldrich syndrome protein, WASP, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WH1" evidence="10">
        <location>
            <begin position="19"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="9">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="11">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="220"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="348"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="533"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="465"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR11446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="597" mass="64785" checksum="9784AF2ED876E38A" modified="2013-05-29" version="1">MPNVSTLTSEDKQIIKKCIPKPTNKIITAAVARLYVAHPNPNEWRFTGISGAIVFAHDMIGNTLFLKMVDISNSNRGIIWDQELYENFQYHQDRTFFHSFELEKCMAGLSFADVNEASAFYRRVNGRLSISSHKNVPMAGGLKMNTKKKYIDKSKIGAPSHFKHVSHIGWDSERGFTTENIDPSWKKLFDDLGQFGFSYEQIEENKDFIREYVVRNGGLGNVKQVPESSQTNTSVLQESIKRPRLPPPPPLPPPPTSPTPSSKTDINKKSPLSLKRVPPPPPRKSHVFMSETSRSLESTSAPPSPPPLRNSVVNQHKSLHVSIVNTNALPELVNSTENDVLLESEAKKAFSHENSTRKSCPSSSSGLSCSNNSADLNSDPTVSSTPASKSDASFLFSNKDKDITSDNPAFSSSSRNSVSQLRLPNKTFTSDGSSGSLSISAFAPPPPPPPPPPPPPPPPLSILTSVSSDSKSASLGSSNKSIAFSVSHSSDEKATSSHNIASIDQTLDLPSEYISSVDRSNLLASIRSSGGVSMLRKVEPASSSRSSSSCFNGISRSTNGAGGHINLEDALVAVLNHRKGKVTLSDDDESEDDDWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWF1</accession>
    <name>M7NWF1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872377.1">
        <property type="nucleotide sequence ID" value="XM_007874186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWF1"/>
    <dbReference type="STRING" id="1069680.M7NWF1"/>
    <dbReference type="GeneID" id="19894189"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00491"/>
    <dbReference type="eggNOG" id="ENOG502SGDH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149439_2_2_1"/>
    <dbReference type="OMA" id="GSWHGGF"/>
    <dbReference type="OrthoDB" id="3358869at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042332">
        <property type="entry name" value="Hsk3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013183">
        <property type="entry name" value="Hsk3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28289">
        <property type="entry name" value="DASH COMPLEX SUBUNIT HSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28289:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT HSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08227">
        <property type="entry name" value="DASH_Hsk3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="76" mass="8498" checksum="1D3E9D139211C20B" modified="2013-05-29" version="1">MYRQSTTPAQIKSRQLSHLNSQLAQLHAHLSDLENHFRVTAIQADAVRRLGGLQGSMFISASKVFGEENTQNMESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWT1</accession>
    <name>M7NWT1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arp2/3 complex 34 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00171</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872032.1">
        <property type="nucleotide sequence ID" value="XM_007873841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWT1"/>
    <dbReference type="STRING" id="1069680.M7NWT1"/>
    <dbReference type="GeneID" id="19893869"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00171"/>
    <dbReference type="eggNOG" id="KOG2826">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059439_1_0_1"/>
    <dbReference type="OMA" id="FRSYFHY"/>
    <dbReference type="OrthoDB" id="148331at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072697">
        <property type="term" value="P:protein localization to cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007188">
        <property type="entry name" value="ARPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058">
        <property type="entry name" value="ARP2/3 COMPLEX 34 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04045">
        <property type="entry name" value="P34-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="291" mass="34149" checksum="7EE3402A8DDA4476" modified="2013-05-29" version="1">MNRKTTSAIDQVISDFDGVLYHVSTPETKTKMLVSTKIGCYKSLMKYDLQTVLERYYGELIVSPEEKYDFSLYIDLEKIFDDEKEKKDLIRSIGLLKRNILSAPFEKAFYLQQLLEKEQKNEQKIKNTEKEIIKIPYRDEEAIFIIPSSDRVTVIFSTIFKEETDIILGKEFVDARRRPAIQNAPQVFYSYRDPPLEIQSLSDLKLSDNIGYVTFVLFPQHYTPQKKENCISKIQLFRNMLCYHIKASKVHMHERMRARVAEFLKVLNRAKLENTEKEKKTASGRSFNVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NX41</accession>
    <name>M7NX41_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uroporphyrinogen decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_00160</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the sequential decarboxylation of the four acetate side chains of uroporphyrinogen to form coproporphyrinogen and participates in the fifth step in the heme biosynthetic pathway. Isomer I or isomer III of uroporphyrinogen may serve as substrate, but only coproporphyrinogen III can ultimately be converted to heme. In vitro also decarboxylates pentacarboxylate porphyrinogen I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>uroporphyrinogen I + 4 H(+) = coproporphyrinogen I + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:31239"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62626"/>
            <dbReference type="ChEBI" id="CHEBI:62631"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:31240"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>uroporphyrinogen III + 4 H(+) = coproporphyrinogen III + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:19866"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="5"/>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872021.1">
        <property type="nucleotide sequence ID" value="XM_007873830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NX41"/>
    <dbReference type="STRING" id="1069680.M7NX41"/>
    <dbReference type="GeneID" id="19893858"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00160"/>
    <dbReference type="eggNOG" id="KOG2872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040933_0_0_1"/>
    <dbReference type="OMA" id="LWLMRQA"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000008">
        <property type="entry name" value="Uroporphyrinogen decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091">
        <property type="entry name" value="METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091:SF169">
        <property type="entry name" value="UROPORPHYRINOGEN DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="14">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR11726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="353" mass="39813" checksum="ED518E199020D331" modified="2013-05-29" version="1">MSIEFPPLKNDLLLRAARGEKVERPPRQAGRYLPEYHEIGQDIDFFAKCRSPELVSAITIQPVDRYDGLIDAAIIFCDILVIPQALGMAIKMVDKKGPCFLNPLETPDDIQKLKLKIDIKKELGYVMDSITLTRKKLNGRVPLFGFAGAPWTLMTYMIEGGRSKTFEKSKTWIYKYSEASKRLLECLTDIVIEFLAQQVVAGAQIIQVFDSHAGELSPYDFKDFSLPYLSDIAKKLPQRLIQLEQSLVPMVVFAKGAWYALDSLCSLGYHCVSLDWKHDPEDAQKINRGRCTLQGNLDPCILLGDINTITQRTKNMIQSFGGGKQYLICNLGHGILHTTHPDSLKIFFEACHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M7P2T2</accession>
    <name>M7P2T2_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_03352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875433.1">
        <property type="nucleotide sequence ID" value="XM_007877242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P2T2"/>
    <dbReference type="GeneID" id="19897039"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03352"/>
    <dbReference type="HOGENOM" id="CLU_091042_1_0_1"/>
    <dbReference type="OrthoDB" id="5403729at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="192" mass="22621" checksum="ABD4493CEF2AFD05" modified="2013-05-29" version="1">MTEKEIIEIRLSRIENIVYGSNNIASDEFISLNIPCFVDFIETKVNNLVKESEVLKKMMNFLNSYSFLLEEKVYSLFKSCNTIRNEKIRLIFLNLHLYNNVLSQMLSIKELSIPDSNIYSQAASKIPQFHILLMTIKSFEIQLNHLSKRIAKILELWYEIGINAVNDCFLEWDERINNINLRLKKQMSSIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M7P313</accession>
    <name>M7P313_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T-complex protein 1 subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_03398</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875483.1">
        <property type="nucleotide sequence ID" value="XM_007877292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P313"/>
    <dbReference type="STRING" id="1069680.M7P313"/>
    <dbReference type="GeneID" id="19897085"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03398"/>
    <dbReference type="eggNOG" id="KOG0357">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_7_2_1"/>
    <dbReference type="OMA" id="SHPQMPH"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03339">
        <property type="entry name" value="TCP1_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000053">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000003">
        <property type="entry name" value="T-complex protein 1 subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000049">
        <property type="entry name" value="T-complex protein 1 subunitTheta, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012718">
        <property type="entry name" value="Chap_CCT_epsi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02343">
        <property type="entry name" value="chap_CCT_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR08230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="550" mass="60210" checksum="DFF627474A4C14FC" modified="2013-05-29" version="1">MGEVVFDMKNAFVARDEQGNPFIILKDQGKKKRLTGNDAIKSHILAAKTVANILKSSLGPRGLDKILISSDGDITITNDGATILSQMEVEHQIAKLMVELSKSQDEEIGDGTTGVVVLAGALLEYAEELINKGIHPIKIADGYDQACKIAVEHLDSIADVVEFSKTDTTNLFRATKTSLGSKIVSKAHDKFSEIAVDAILSVADLDRKDVNFELIKIDGKVGGALEDTMLVKGVVIDKDMSHPQMPRSICDAKIAILTCAFEPPKPKTKHKLDITNVEEFKKLQNYEREKFEEMVKKIKDTGANLVICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAVATNGRIVPRFEDLTAEKLGTAGLVRELSFGTTRDKMLVIEGCVNTRAVTIFIRGSNKMIIDEAKRAIHDALCVVRNLVKDNRIVYGGGSAEISCSIAVANAADKAPGIEQYAMRAFANALDVIPMALAENSGLSPIETLTNIKSKQIKYSNPALGIDCMQKNNDDMKEQYIIDSLINKRQQLLLATQLCRMVLKVNDVIISGSENDSHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7P468</accession>
    <name>M7P468_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sphingolipid long chain base-responsive protein PIL1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_03129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Negative regulator of cell wall integrity (CWI) in unstressed cells, probably by inhibiting protein kinase ksg1/ppk21 activity and regulating their downstream CWI pathways pck2-MAP kinase pathway and protein kinase gad8 pathway. Activity may be regulated by the transient increase of sphingolipid long chain bases (LCBs) during heat stress.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875187.1">
        <property type="nucleotide sequence ID" value="XM_007876996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P468"/>
    <dbReference type="STRING" id="1069680.M7P468"/>
    <dbReference type="GeneID" id="19896816"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03129"/>
    <dbReference type="eggNOG" id="ENOG502QQ1T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046464_0_2_1"/>
    <dbReference type="OMA" id="NRWLGKG"/>
    <dbReference type="OrthoDB" id="5599269at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036286">
        <property type="term" value="C:eisosome filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000005">
        <property type="entry name" value="Sphingolipid long chain base-responsive pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028245">
        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962:SF1">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13805">
        <property type="entry name" value="Pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00053166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="36965" checksum="7F28A72A1796C7D1" modified="2013-05-29" version="1">MHRTYSVRSTRTSGTSQANFFPLPVSSTKANRFFGLRSIGHSFRKSSAAIFSPDLARRLAVLIKMEKNVMRSYELVGRERKEVAKQLSLWGEDCDDDISDITDKLGVLIYEIGELEDSFIDRYDQYRMTMKSIRNIEASVQPSRDRRQKLIDQIYMLKHKEPDSQKLLVLEQELVRIEASCLVAEAQLNNTTREKLKTAFTYQFDAIKEHSEKLALIAGYGKYLLELLDDSPITPGEARATYNGYEQSKQIIIDCENALSQWSFETSSIKPTISFHNKIDELTDGLSNQNKNLQNDSFWVSNIKDEKRPQELEESNKIILAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7P4N0</accession>
    <name>M7P4N0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Postreplication repair E3 ubiquitin-protein ligase RAD18</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Postreplication repair E3 ubiquitin-protein ligase rad18</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 18">RING-type E3 ubiquitin transferase RAD18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PNEG_02935</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 25">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RAD18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874980.1">
        <property type="nucleotide sequence ID" value="XM_007876789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P4N0"/>
    <dbReference type="STRING" id="1069680.M7P4N0"/>
    <dbReference type="GeneID" id="19896622"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02935"/>
    <dbReference type="eggNOG" id="KOG0287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028491_2_0_1"/>
    <dbReference type="OMA" id="IPNTGPR"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097505">
        <property type="term" value="C:Rad6-Rad18 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000172">
        <property type="entry name" value="E3 ubiquitin-protein ligase RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039577">
        <property type="entry name" value="Rad18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="21">
        <location>
            <begin position="27"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="22">
        <location>
            <begin position="168"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00082369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EMR08765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="280" mass="32393" checksum="8CBB228BE1E0D497" modified="2013-05-29" version="1">MINISDSLDWISSMLPEMAVLEEVLRCRICRDLMQTPLITGCCHTFCSLCIRRCLSQKQQCPLCRQPEQENRLRRNTSIEEVIEIFERIRPGLMALANPLSNTEIKLSNTDSIPTIVKCPVCYQSVDYDKIHMHLDICLNQKSNTSLQTEISPKTIPHAYSRLPKLNYALLSESKLRSELKSLGLKISGDKAMLQRRHTEWINLWNANIDSKTPVSKRILLEKLDAWDQMQLKTTTMKNISDKDWIQTYKTDFENLIENARQSKKRKADTSPKNEPPETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7P4S9</accession>
    <name>M7P4S9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874636.1">
        <property type="nucleotide sequence ID" value="XM_007876445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P4S9"/>
    <dbReference type="STRING" id="1069680.M7P4S9"/>
    <dbReference type="GeneID" id="19896308"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02617"/>
    <dbReference type="eggNOG" id="ENOG502RZJP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_649111_0_0_1"/>
    <dbReference type="OrthoDB" id="5348546at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22699">
        <property type="entry name" value="FHA_PLM2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="77"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="423" mass="48629" checksum="60FB94200B348A6B" modified="2013-05-29" version="1">MEIEILDEELSKKFSKEKTQNLSSSPLYYLQNSDEKNPYLTPDLSSCADLYPSLSPQYTYDSFNNFPFLRLDESKAVYIGRSSQSCNLSISKKNMFISRIHAKLEYHSENKAVYVTCLGWNGMLLHIQTEHGPRKIRKGETSVVEWVPNVGSIIVEIAGSYSRVLWPTSLELSIDNKTRIDEINSPYTNNENVQPFSQKIYRNLGFYKNKPERSPLKRLTYQDFENTRIYDSSIFPNSNYFPLSASLDNSDTYVNHSSDNPYSTFLSTDKAKINTNNSLSVDIKNFGPEPDSIDSSLLDSVLTTLAFSPLSAVPLSTLTCLFPSTFLKEDVEKWLRNAGQFIAEIKREGKDASGKPLENQWYYVPEKDDNEERKASLLPFIRPIRQSRKIHKQYYWKKPRLPTSNNITALTFVKKKKKISRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7P537</accession>
    <name>M7P537_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">18S rRNA factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02750</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF2/ABP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874781.1">
        <property type="nucleotide sequence ID" value="XM_007876590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P537"/>
    <dbReference type="STRING" id="1069680.M7P537"/>
    <dbReference type="GeneID" id="19896441"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02750"/>
    <dbReference type="eggNOG" id="KOG3152">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054086_2_1_1"/>
    <dbReference type="OMA" id="TENECHT"/>
    <dbReference type="OrthoDB" id="287393at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12263">
        <property type="entry name" value="RRM_ABT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039119">
        <property type="entry name" value="ABT1/Esf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034353">
        <property type="entry name" value="ABT1/ESF2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311:SF7">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="64"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="180"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="259" mass="30165" checksum="C18D524FC61D0290" modified="2013-05-29" version="1">MNSRNKTNNSDSLNNSKKSNIKSTIDIDNTLSKTNKEAIETILFCGKTLTKKVLDASEKSKISGIVYLSKIPPFMKPETIRRLLSQYGEIGRIFLAPEDYKSYIKRIRYKGNKKKKYTEGWVEFKEKKKAKLAADTLNTTIIGGKTSTYYHDDIWNIKYLPKFKWSHLQEQIASKSASQASKLRAEISRTKRENQNYIKNYEHGKMIENIKNKKRKTNEDISSNSEKRTKYKFKQREAIINNISTDIKNEINKVLDKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7P5E7</accession>
    <name>M7P5E7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="7">PPIase</shortName>
            <ecNumber evidence="2 7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02449</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 7"/>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874457.1">
        <property type="nucleotide sequence ID" value="XM_007876266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P5E7"/>
    <dbReference type="STRING" id="1069680.M7P5E7"/>
    <dbReference type="GeneID" id="19896142"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02449"/>
    <dbReference type="eggNOG" id="KOG0865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_4_3_1"/>
    <dbReference type="OMA" id="FKSIVPR"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000013">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="5"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="162" mass="17605" checksum="0AFC1D52441120F3" modified="2013-05-29" version="1">MKNVYFDVSSGNAPLGRIVFKLFDDVVPKTAENFRALATGEKGFGYKGSTFHRVIPNFMIQGGDFTRHNGTGGKSIYGERFPDENFKLKHDKPGLLSMANAGPNTNGSQFFITTVSTSWLDGRHVVFGEVIEGMDVVKKIESYGSSSGTPSAKVVIQECGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6C4</accession>
    <name>M7P6C4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02360</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874364.1">
        <property type="nucleotide sequence ID" value="XM_007876173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P6C4"/>
    <dbReference type="STRING" id="1069680.M7P6C4"/>
    <dbReference type="GeneID" id="19896053"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02360"/>
    <dbReference type="eggNOG" id="ENOG502T0CY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086133_1_2_1"/>
    <dbReference type="OMA" id="TMAIGHE"/>
    <dbReference type="OrthoDB" id="261831at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="50"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="138" mass="16410" checksum="10060A559C54336C" modified="2013-05-29" version="1">MGSKTRYNGLFHRENRSSLSKTKYPQFDQDIYYSSFDQQYDGNSFGLSGNQNEYDIDHLSSKIKTLKDITISIGDEIRESSVFLSSMNDKFSSTRVMLNSIFKNMNRIAMQQNIGWFHFFLFIFFVCILFWGFWYIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7P7E9</accession>
    <name>M7P7E9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01949</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873926.1">
        <property type="nucleotide sequence ID" value="XM_007875735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P7E9"/>
    <dbReference type="GeneID" id="19895643"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01949"/>
    <dbReference type="eggNOG" id="KOG4754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039184_1_1_1"/>
    <dbReference type="OMA" id="NALPCDT"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR09765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="23732" checksum="1150FBF8423DF609" modified="2013-05-29" version="1">MVFHKEIYIMRHAQAEHNVSKNYNLKDPVLTEFGKDQARLLLLHFEQLKKVELIISSPMRRALETVMIGFDGYLDLKDQKHINYPSIPLIILPQLQETSDRNCDTCSSLKNLKSWFPSLDWSFCSQEQLLKTGFFAYEPSMLEKRAIWLRNWISKRKEGKILIVSHLSFIKYLVDDSTYWANLEIKKYNIGTGPIFKQVPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7P7L4</accession>
    <name>M7P7L4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA methyltransferase 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02026</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874006.1">
        <property type="nucleotide sequence ID" value="XM_007875815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P7L4"/>
    <dbReference type="STRING" id="1069680.M7P7L4"/>
    <dbReference type="GeneID" id="19895720"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02026"/>
    <dbReference type="eggNOG" id="KOG4589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009422_2_0_1"/>
    <dbReference type="OMA" id="WSQVAVN"/>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF18">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005461">
        <property type="entry name" value="23S_rRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="8">
        <location>
            <begin position="57"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="305" mass="34482" checksum="1FB760A502A079A4" modified="2013-05-29" version="1">MTILNLKIYKSKISKLFFIYTQKFHSSNQLNSNSSSKRWIQRQKNDYFTREARVLQYKSRAAFKLLEINEKYKIFKPGNTVIDLGFSPGSWSQVAVEKVGSKGRVLGLDIIPSQPPAGASSMQGNFLSKATQRAIIMYLSDPNRGRQSAISSLSSENGEKLSYIDLEKRLEQNNTKCYNSKVADVILSDMLAPLPQIDGFYKRSLSDPYHRLANVSGISVKDHGASMDLCDSALLFCIDALHVGGNFICKFYSGIEDKILLKKMQKVFQEVKREKPCASHSESRESYFIGLKMRASINKKDIENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7P920</accession>
    <name>M7P920_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome assembly factor mrt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01586</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">Associates with the pre-60S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873540.1">
        <property type="nucleotide sequence ID" value="XM_007875349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P920"/>
    <dbReference type="STRING" id="1069680.M7P920"/>
    <dbReference type="GeneID" id="19895281"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01586"/>
    <dbReference type="eggNOG" id="KOG0816">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071690_0_0_1"/>
    <dbReference type="OMA" id="LEWAENY"/>
    <dbReference type="OrthoDB" id="10262308at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05796">
        <property type="entry name" value="Ribosomal_P0_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000005">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000003">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033867">
        <property type="entry name" value="Mrt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051742">
        <property type="entry name" value="Ribosome_Assembly_uL10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841:SF1">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 MRTO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="7">
        <location>
            <begin position="125"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="236" mass="27588" checksum="E64D1BF6C2FC8D74" modified="2013-05-29" version="1">MPKSKRFKIVSLTKTKKKDFEHKKKLFKDIRDYIDKYEYIWVFCIENMRNVHFKEVRNKWKDSRIFMGRIKVIAKSLGVTKDEEYRENLSELSKMLTGNAGVLFTSEPVSFVVDFFSKFSRMDFARSGFTSPFTFTVPAGTVYSRGGKISIDNDNPLPHTFDSVLRGLGMPTLLKNGHVTLFNEYTICKEGDILDSRQTRLLKIFGVIMSEFKIKLKGYWSSLDNKVRFMEDYLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7P9A4</accession>
    <name>M7P9A4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01151</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873065.1">
        <property type="nucleotide sequence ID" value="XM_007874874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P9A4"/>
    <dbReference type="STRING" id="1069680.M7P9A4"/>
    <dbReference type="GeneID" id="19894848"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01151"/>
    <dbReference type="eggNOG" id="KOG3662">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011607_0_0_1"/>
    <dbReference type="OMA" id="LHCMKYP"/>
    <dbReference type="OrthoDB" id="5977743at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF4">
        <property type="entry name" value="METALLOPHOSPHOESTERASE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="85"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="451" mass="53034" checksum="99E70EBBE05A313F" modified="2013-05-29" version="1">MAEILKNKRIVFFPELFEQNFMKKLKEIIIMIYKKKRHLSKLKISIIISWFIILWYGEVNIFKQTISRCSWSLWEKWEEGTKPYRVALIGDPQLVDKHTYNRSFLLTAFTNFYTDKYMKRNWKYLNNELHPQSLIFLGDLLDGGRDLEMKSWIKEYKRFDDVFFQPPGVKVISTLPGNHDIGFSDGVTLNRLNRFRAYFGESSSSYVLGNHTFVLLDTISLSNTINTQVSEYTKQLLDDLKNTYDKDFPRILLSHVPLFRPANTPCGPNREKNTSIKLERGYQYQNVILSSISTYVLEIVRPIAVFSGDDHDFCEVKQTIKKYGITIIERSIKSFSMAMGISQPGVQLVSLYNPSLKKTENQTFQTKLCLLPKQYYIFSLYLITFIVTVSIICIYQYLFVEKDLQYLSTYTNKYKNISHESSFKSLDHILSDIINIAIIVFPWYLYLLIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7PA17</accession>
    <name>M7PA17_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exosome complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00856</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the C1D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872766.1">
        <property type="nucleotide sequence ID" value="XM_007874575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PA17"/>
    <dbReference type="STRING" id="1069680.M7PA17"/>
    <dbReference type="GeneID" id="19894554"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00856"/>
    <dbReference type="eggNOG" id="KOG4835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1272756_0_0_1"/>
    <dbReference type="OrthoDB" id="1421013at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011082">
        <property type="entry name" value="Exosome-assoc_fac/DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341:SF3">
        <property type="entry name" value="NUCLEAR NUCLEIC ACID-BINDING PROTEIN C1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341">
        <property type="entry name" value="SUN-COR STEROID HORMONE RECEPTOR CO-REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="217" mass="25064" checksum="3D586C3D271EE368" modified="2013-05-29" version="1">MATKIHPNEGDLNLLIENLKERVFCLENIFFEFKLNDQNNLSELSSKLSMLDKAKLYITLCYAINSLIFMILKLNQVDLKNHAVMKELKRVEEYVLKIKEIEMLFSKRTMALNKQVASRIIAHDLSGNLKNDNKKESLHIQDCLNLNMSSKGRVHIKFEESNAKLSETCLDAKQIKIEKDIGTSTKHFQDLMISMGSYSKTQNRTSKKQKKYKTSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>M7PB40</accession>
    <name>M7PB40_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_00698</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872597.1">
        <property type="nucleotide sequence ID" value="XM_007874406.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7PB40"/>
    <dbReference type="GeneID" id="19894396"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00698"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_27_6_1"/>
    <dbReference type="OMA" id="RRRYILW"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000825">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000006">
        <property type="entry name" value="ATP-binding cassette, sub-family C (CFTR/MRP), member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF353">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN_PERMEASE VMR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="545"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="977"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1066"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1153"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1255"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="322"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="653"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="1070"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1316"/>
            <end position="1560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR11100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1581" mass="181947" checksum="00ED8A65F7121CB0" modified="2013-05-29" version="1">MMYLEEYTNSIWKDNDFTEYFKYKYIIWISALYLLISLLILLSTGIYVIVLKYCKNSKKYISLTQEDNALNFLGMSFMDICFSKKASSFLHSEFDESNKQYLKEYKVKPPKQASVIITEGIIILFMIFLYFLFLGGSKHPLFITIRIFAWVYVFILVVIRLASIDVDSFPLSTLWYHTSFLYAFHWPLFYIDLRSMIIAHEPTIFIILSAINLVLLSVLNVIVLLSRKGNRTVRLIALNGLKPSKEKLSSILSMLTFSWVDSIIVQGFRKNLTFSDIWDLSEGEHAAAVMDAFCITKKASYLIYTLLRHFKATLIIQFIWEILHSIMSFAPVILLKLILEYIDNPKEHAKEVVWIYIVGMFFSILISSFFMGQSYYIGRKLCIKVRSALIGEIYSKALRRHTSSNVITSNDDTIDSFQASIGTIINLVAIDAYKISEVYAYIHNLFITVPLHLIVAFILIFRIFGWSALTGFSTIILFMPVNTYFSTLYRKIQKEMMSISDTRIGLINEIFQNIRLIKYFAWEENVTQNINNIRENEIKQLWKKYILLSFALLSWNASSVIASLITFLVYTKIAHNKLTAPIAFTSLALFNSFRTPLEQLSEVLSSFLDSKVSMNRIDAFLKEEEIQKYDRDTDFPSSDDLIIGFKNASFTWASKNDVIKNTEFHLNSFRIYDLNIKFPLDKLTVIIGPVGSGKTSLLMALLGEMTNLSGKGFCPGKYNKNHLIPDHQTGFTESVAYCAQQPWLLSDTIRNNILFYSSYDAQRYNKVVKACALERDFQILDGGDQTEVGEKGIILSGGQKQRISIARAFYSSAKYVILDDCLSSVDSYTAKWIFNYCIKGELSNGRTIIMTTHNENLCVPEADFVLIMDNGRVSAQGAPNDLFDSKLLDRHESSLKTVSSSTSLIRSIHSSQASSKEQAFDLYEEKDETNEYDIKNTKTFDAFGPCKGKLIEEECYLSSSINKSIYIEYMKYFGGKFFLFVLFLSFIIPPVLNVCQSLWVRKWTQDKSIRSSYYPRDFQKDQLHEKNNIFYTIYYFFITTFRRFSHTSTNHAHQTKYQDSFLDVNYYINIYILISLLYIFSTFFRIIMAFTGGIRVSIKLHEKLFQSVLGAKIRFFDITPIGRIMKRFSNDIGVVDQEVSYISLTFVYDFFNSIFLVAVITYIIPSFLISEIFIMIIYIAIALFYIRPSRRLKDLDSITKSPIYQHFRETLTGINTIRAYGYEKIFIRENLQKLDLNNRPFIYLWACNRWLSIRIDFIGGLITIFAGIFIVLNINKLDAGFAVLSVFENFFFIEQEAPSIIPSNRPGKNWPEKGEILVQNIVVQYLPELQPAICNVSFKVDPCSKVGIVGRTGAGKSTIAATFFRLIELQSGSIIIDGINISTIGLRDLRSSLTIIPQDPVLFKKSLRYNLDPFNIYTDAEIFEALRRVHLIGSETINDESKNSNTNIFLNLDTQIAEGGNNLSHGQRQLICLARSLLKSSRIIIMDECTASIDYNMDAKIQKTIRSEFSYSTILTIAHRLKSIIDYDKILVLDSGKLVEYDHPYLLLQNPQSEFRFMCESSGEYDTLRRLAQEAYENKCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7PB74</accession>
    <name>M7PB74_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00736</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a component of both the DNA-binding general transcription initiation factor complex TFIID and the transcription coactivator SAGA complex. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription. At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B. SAGA interacts with DNA via upstream activating sequences (UASs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TAF10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872637.1">
        <property type="nucleotide sequence ID" value="XM_007874446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PB74"/>
    <dbReference type="STRING" id="1069680.M7PB74"/>
    <dbReference type="GeneID" id="19894434"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00736"/>
    <dbReference type="eggNOG" id="KOG3423">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064104_4_1_1"/>
    <dbReference type="OMA" id="GFECDDV"/>
    <dbReference type="OrthoDB" id="154356at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="HFD_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017246">
        <property type="entry name" value="TFIID_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01443">
        <property type="entry name" value="TFIID30KDSUB"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR11140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="165" mass="18931" checksum="423E45EC2987B9DA" modified="2013-05-29" version="1">MSDEKEIQEEKTGNDEIKMEDVNTENVSEKMEESTEIPASYRKQKDRTLREFLNMMDDYAPIIPDAVTDYYLSIAGFECDDIRIKRLLALAAQKFIADIAQDAYQYSCIRSSSMMSAVLSNQTGYTGSIRNRYGKEKGKTVLTMEDLSAALHEYGINMKQPDFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7PBT9</accession>
    <name>M7PBT9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_00364</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872237.1">
        <property type="nucleotide sequence ID" value="XM_007874046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PBT9"/>
    <dbReference type="STRING" id="1069680.M7PBT9"/>
    <dbReference type="GeneID" id="19894062"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00364"/>
    <dbReference type="eggNOG" id="KOG2208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003293_1_1_1"/>
    <dbReference type="OMA" id="DHAGQQV"/>
    <dbReference type="OrthoDB" id="10027144at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22448">
        <property type="entry name" value="KH-I_ScSCP160_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22450">
        <property type="entry name" value="KH-I_ScSCP160_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22452">
        <property type="entry name" value="KH-I_ScSCP160_rpt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057778">
        <property type="entry name" value="KH_Vigilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054548">
        <property type="entry name" value="SCP160-like_KH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22952">
        <property type="entry name" value="KH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24668">
        <property type="entry name" value="KH_Vigilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="108"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="181"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="266"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="503"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="588"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="674"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="740"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="824"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="900"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="981"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="1158"/>
            <end position="1225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR11335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1232" mass="139466" checksum="CD98EE578F6F7222" modified="2013-05-29" version="1">MSMNLSLEKNKLFLHDLQSNQTNSSFVHTQKNYLNDRNFDNSSEKYIDYDMSSNYSIIGFNSEESFPTLKSSIASATKKSKTENINISKSNSDENKKKHMAVPLIKTTIETIRLEASQRMPLKEFGSKSSVGEIARQIMEETHTHIDISTARKTGITTFLVRGKPEDVHHARRMLMKELSQKVTIKLLVPLNTLGFIIGSKGKVLNNIIEKSGAKIQFPKRNISRDLPCNNANDEYNDETVEIIISGDVEAAESAKKEIEAIVEERTSHITVKITSINPKFYGLISSTNNSRIQEWIQDKDLKIDIPSPYLESDSEKLKPIIISGEKNLVNNVKTEIEAIYSELESTTVSASIVISKRLHKYLDEKLLQDILSRLKCSVIIPPYSSPSENLLISGIPSFIGETIQCLMEKANSICLDMLDITKAHPSASDHIAHARDITRYFLKKKEIVRIEKEYQIQITLPSMDTLLKQNLTSIVYEFAGENAGNVKNAKKEIIMLINSYPPYRILRLNLDPLLHCHIIGQKGRNLQKIREQYFIDILFSNEDSFNSEIVLIYEGRPGEKLPSAPTIQLTLEKVAELLKKTATEMADIISRDIYIPDKYHKYILGPKGSTLNSIIKDSNSIVKVKFSTAKPRKFDNTVVEENMVNVRGVSFGVEYVIKEIEKIVENLKFQDQNSYSLTFDFPQKFLKDLFDKGHNNISKIRELNVKMTTEEGKITIQGAKNNVEEAKSHIQEFIKKLDEQTVLHLSIPVKHHGSLIGQGGKFVKRLEEKYQVKINFPRENLENKDADNKKSEAKDEVTIRGDKNGVTLAKLELLDLLDYEKEHGNTVTFTVPMFTIAQILGKAGNNINELKNETETRIEIEKSTSDDPSALATIFIQGTKDGIKRAKNSILDTVKTIQDQVTRTIFVNRKYHRTLIGPGGSTLRNIITECGAVGDRSQLAKIIQFPKPEKKSDEIVIAGNKELVDKIIEKINSMVKEIEEKITLIIPVPLSKMKTIVGKEGNVRKELESKYSVVIKIPKKPKDSTEKNAQIKVIGKKEQVDKAAKEINTFIKIENSSEINIPLKCHPYISENGIFARRMKTLYGVILEYHDDSIPKEKIEEIDIDEKVLDENQKYPWSVVMDLEEDKEISWTLKGKMGNIEQVKEIINAALEQMKHHTATGYLKVPPNYYGIIIGQGGSRISQIKSESDCCINIPRTNNGNLITLRGTLDGLEKARSMIINTLDYINNKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7PBW7</accession>
    <name>M7PBW7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase I-specific transcription initiation factor RRN3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872271.1">
        <property type="nucleotide sequence ID" value="XM_007874080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PBW7"/>
    <dbReference type="STRING" id="1069680.M7PBW7"/>
    <dbReference type="GeneID" id="19894095"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00397"/>
    <dbReference type="eggNOG" id="KOG2434">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010579_0_0_1"/>
    <dbReference type="OMA" id="VCSPAIV"/>
    <dbReference type="OrthoDB" id="26970at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001042">
        <property type="term" value="F:RNA polymerase I core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007991">
        <property type="entry name" value="RNA_pol_I_trans_ini_fac_RRN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790:SF0">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IA RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05327">
        <property type="entry name" value="RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="592" mass="68583" checksum="329DB58E56599D65" modified="2013-05-29" version="1">MISLNGFSKKLSFSEDSNFSEDMIHKYIINALETCDKGDKEAYEDLRKKLSMDFQSSEALSSLQLKQLLFSLIQVASRLNSNYQSLINDILKIHWVERDDEFVSVYIRFLGTIASAHSGYIPLIIKMLVQTMALDTCSITSLPGETSISYDLIYDRVHFSLKYILDLVPISYTFLFSILAMEFPYKSHKTLLQVAYLKNLLRVLEYAPVISSQVFGLIIDKIIQIDVEIQIELEDLDEEVDELTGIVMNEMHDNADKSLSYNDYNNIEENDQNEESLDISENHVYFQAITCIREMVDKLDCMLVVLFNYLDAIFSSSKEVNHKSESLADIIFGDLLRAFDSIILHTFRSRYTQFILFWASQINEKYTNMFLGLILERALDDSRSHVSRSISCVYVASFVARAASLNKDMVRNAINMLCGWINVFLDGWENETGSSGDFVKKFSIFYFIVQSVLYIFCFRWRDLTDDDAQEHGTGWFKSLFILQRAIASELNPLKYCSSNIVSQFSEIAHKLNFLYCHPIIQQNKQSTDISSVFYLQSPDQSKSTIHIDIHSYFPFDPYHLKLSRRFIDHIYIEWKSITELDHYQITIDSEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7PC74</accession>
    <name>M7PC74_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_00513</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872401.1">
        <property type="nucleotide sequence ID" value="XM_007874210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PC74"/>
    <dbReference type="STRING" id="1069680.M7PC74"/>
    <dbReference type="GeneID" id="19894211"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00513"/>
    <dbReference type="eggNOG" id="KOG3281">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1343769_0_0_1"/>
    <dbReference type="OMA" id="RCEIKDE"/>
    <dbReference type="OrthoDB" id="16535at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010591">
        <property type="entry name" value="ATP11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126:SF0">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126">
        <property type="entry name" value="CHAPERONE ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06644">
        <property type="entry name" value="ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR11500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="204" mass="24070" checksum="952AF3E9D51EF59B" modified="2013-05-29" version="1">MKSNKENTQTILESNFVQKNRNLAQSNTKILKNEKKEQIKTLSFYIDIEKIRSYNVKEIELIWKACHSQNDHSLCGLIPSQKFEIMEKNAKKYNMFILPINHAQGIEMHFLQWFFVNDFTKYILITSLLEYKAKGEFARPHTFISYYTDLSSDKNIVLMKGELEKNRGITMNDLRIIIFQIEIFFSATEGNQKKPTQIRTSKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M7PC81</accession>
    <name>M7PC81_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875616.1">
        <property type="nucleotide sequence ID" value="XM_007877425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PC81"/>
    <dbReference type="GeneID" id="19897211"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03524"/>
    <dbReference type="HOGENOM" id="CLU_2159492_0_0_1"/>
    <dbReference type="OrthoDB" id="10572559at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="111" mass="12451" checksum="F6AFE12C1F7BDDD6" modified="2013-05-29" version="1">MPSQTISSPTVETGAEQVKTETLLMGNKSKDKLSKRRATEPTETKESPEENESSDESSEYSDPPPKKHKKENSNEDEESGSEEEEESGSEEIEDTQETEEDSDDDFEDDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7PC91</accession>
    <name>M7PC91_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872421.1">
        <property type="nucleotide sequence ID" value="XM_007874230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PC91"/>
    <dbReference type="STRING" id="1069680.M7PC91"/>
    <dbReference type="GeneID" id="19894229"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00531"/>
    <dbReference type="eggNOG" id="KOG0111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_27_1_1"/>
    <dbReference type="OMA" id="YKPVWID"/>
    <dbReference type="OrthoDB" id="407442at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037">
        <property type="entry name" value="ATPASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR11520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="118" mass="13743" checksum="BF55C24229599DCF" modified="2013-05-29" version="1">MLHEMFIPFGEIVGVELPRDETTEEPHQGFGYVEFEHIEDAREAIDNMDQSEVWGRILHVTTAKAERKILEGLGSKIPVWEQEAWIQQYQINKEDRKIVEEKQEIIQSSFVPVGPRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7PDS8</accession>
    <name>M7PDS8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein PBDC1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_03101</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PBDC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875156.1">
        <property type="nucleotide sequence ID" value="XM_007876965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PDS8"/>
    <dbReference type="STRING" id="1069680.M7PDS8"/>
    <dbReference type="GeneID" id="19896788"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03101"/>
    <dbReference type="eggNOG" id="KOG4093">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103791_1_0_1"/>
    <dbReference type="OMA" id="IQFYAFE"/>
    <dbReference type="OrthoDB" id="10248897at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990593">
        <property type="term" value="F:nascent polypeptide-associated complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061770">
        <property type="term" value="F:translation elongation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3560.10:FF:000001">
        <property type="entry name" value="Protein PBDC1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3560.10">
        <property type="entry name" value="yst0336 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023139">
        <property type="entry name" value="PBDC1-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008476">
        <property type="entry name" value="PBDC1_metazoa/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021148">
        <property type="entry name" value="Polysacc_synth_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410:SF9">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04669">
        <property type="entry name" value="PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysaccharide biosynthesis" evidence="5">
        <location>
            <begin position="16"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="150" mass="18163" checksum="09FB635C83BCE914" modified="2013-05-29" version="1">MTSKSEKYLIENVEDIEKQFAVKAVEHAQVYWKLLTRTKGSTLRLTRVDHEIYNHFIREFQEYASKESVSLIDENKIKSSENKARWRKFMMIYENKIEDYNFGTLLRIDSHGEYEEKTTIFVPRIQFYAFEIARNQHGLNDWIYETYKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7PFL3</accession>
    <name>M7PFL3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02578</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CENP-W/WIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874593.1">
        <property type="nucleotide sequence ID" value="XM_007876402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PFL3"/>
    <dbReference type="STRING" id="1069680.M7PFL3"/>
    <dbReference type="GeneID" id="19896270"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02578"/>
    <dbReference type="eggNOG" id="ENOG502R10N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159428_1_1_1"/>
    <dbReference type="OMA" id="YILFMQE"/>
    <dbReference type="OrthoDB" id="2543597at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13732">
        <property type="entry name" value="HFD_CENP-W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028847">
        <property type="entry name" value="CENP-W"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052484">
        <property type="entry name" value="CENP-W/WIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34832">
        <property type="entry name" value="CENTROMERE PROTEIN W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34832:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15510">
        <property type="entry name" value="CENP-W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="9022" checksum="83B9C392BF3A300A" modified="2013-05-29" version="1">MTKPYPRRTLKTILKAHIPHRRLAKNLDVLVYLDYLLFLSTLVRTATLEARQMNEKTLRVPHLHKTIQLSLDRFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7PFX3</accession>
    <name>M7PFX3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inner kinetochore subunit AME1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874303.1">
        <property type="nucleotide sequence ID" value="XM_007876112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PFX3"/>
    <dbReference type="STRING" id="1069680.M7PFX3"/>
    <dbReference type="GeneID" id="19895999"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02306"/>
    <dbReference type="eggNOG" id="ENOG502R7H1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_642692_0_0_1"/>
    <dbReference type="OrthoDB" id="5377952at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048743">
        <property type="entry name" value="AME1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20994">
        <property type="entry name" value="CENPU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inner kinetochore subunit AME1" evidence="2">
        <location>
            <begin position="252"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="427" mass="49241" checksum="1D7282800048CE9B" modified="2013-05-29" version="1">MSRELWNKNQAIERHQKQATRQRGAVKHKVRDVPFEIHPIYLGSSKFSDKNRNENRESLLIKELEKKSSSIRHLDASLVQSPSISASRALNGSQKNVYKYEDYGGRRDSVDHRQTHYKIPTPSFARRTGSPATKPPPRISVGLTPLKEHFLNDNVVKPSLKRTLQTTQSVSDMKRLKKTRIKQVKSGKTVKRQKIHESPLVEEYSDQYHSDGETGSDKEENIDKDSDLEDEEHDSSYDETETKFVIAVHKSSERSTASVNEIDVVSHVVSELLKRLRRKTESTYAKKVIHAFEDEVSVKFLEMTDIFDNYLILDGAVKKSTRNISHLRNELFTIRKARNDVALKMHHLRQHHNDINNENQALKSIQNFLEEIEILHNKIPSDVQHTEKTGIVSLLHTVTPFMRKSWGILEHLTAFNTFLEKVDKALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7PGB1</accession>
    <name>M7PGB1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874057.1">
        <property type="nucleotide sequence ID" value="XM_007875866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PGB1"/>
    <dbReference type="STRING" id="1069680.M7PGB1"/>
    <dbReference type="GeneID" id="19895771"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02077"/>
    <dbReference type="eggNOG" id="KOG2043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002149_2_0_1"/>
    <dbReference type="OMA" id="SWLYHLI"/>
    <dbReference type="OrthoDB" id="342264at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035361">
        <property type="term" value="C:Cul8-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990683">
        <property type="term" value="P:DNA double-strand break attachment to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18436">
        <property type="entry name" value="BRCT_BRC1_like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18437">
        <property type="entry name" value="BRCT_BRC1_like_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18438">
        <property type="entry name" value="BRCT_BRC1_like_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17743">
        <property type="entry name" value="BRCT_BRC1_like_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053036">
        <property type="entry name" value="CellCycle_DNARepair_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667:SF1">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16770">
        <property type="entry name" value="RTT107_BRCT_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="1">
        <location>
            <begin position="86"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="1">
        <location>
            <begin position="320"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="1">
        <location>
            <begin position="576"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="1">
        <location>
            <begin position="688"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="803" mass="92551" checksum="0D6862ACFA02C548" modified="2013-05-29" version="1">MTIFKDVVFYLDGFAPDVDKQLEKYGATRATLPDDYSQLTHIITTDFNRKTTRLMKKKGIPIINVNWVEASIRRKHLQNIKYFSADPRHFFTGVVITCVGLSDGNRNAIHEGALALGGQCTEVLSKSVTHIITLDVNNETCRQVLKRPELGIKILSPAWFNDCLKQRQRVDETPYLLTDYIFDENKTKTESVLPHMIKKINDSVENLNEIPLKFTKQVLKNKKIFFSKDLEINESLLYTIETIVVSFGAIVVSSIQNATVFIGIYREGNEYIQAALQGIIIGNLTWFYWMYVYETWVNPELNLLHYPIVKTGLPEMHEMVITISNYQGESRQYLEKLIKALGATFTKNMTPNNTHLIIPCESGQKYLAALEWNIHIVNHLWLEETYAEWKLQNITTPRYIYFPPKTSFMKIVGNTPINLDVIKLFYENVSNDLIEKKSPLKESNLLKHSNNISSNNNELSLDSFSSSLNMPSTLDNFDLQIHSDNESSFQASDCNLTKENFPSFHKRRAATVALERLHNEIMPDVLLYQKECKRKTFSDSSGDMTNSRKKPKELFIEFKDLKNSQVLKKTIAKFFPTNKDFRDYSVRILVTGYKDWDNQMEKALLTIGIATVQDAKDCTHLVTSRIQRTQKFLSALSYAPKILSVDWIKACLKERKIMDENNYFLIDPESELKYSFKLSESLDRARKNKHSLFKGYLFQISPAAVSNYNNGIDTIKQIIEVNGGVCISAISRKNRIEYGLSPILISNISDTRILKHFIEKRKEAGKVPLVYNMEWVLTTVLRQELSFTDENSLLEEYNHLFMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M7PGF2</accession>
    <name>M7PGF2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_02120</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ORC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874101.1">
        <property type="nucleotide sequence ID" value="XM_007875910.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PGF2"/>
    <dbReference type="STRING" id="1069680.M7PGF2"/>
    <dbReference type="GeneID" id="19895813"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02120"/>
    <dbReference type="eggNOG" id="KOG1514">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012774_1_1_1"/>
    <dbReference type="OMA" id="WVETEIP"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000199">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041083">
        <property type="entry name" value="AAA_lid_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF23">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17872">
        <property type="entry name" value="AAA_lid_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="12">
        <location>
            <begin position="39"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR09534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="711" mass="81718" checksum="CDC41CB5346ABCDD" modified="2013-05-29" version="1">MPLKKSIIKPYENDFEWIGKGIESSEGIFFYKAVCCEKETFYIGDCILVRSNSGKGSWAAMITCFYETKLGEKMADLLWFERSTHIRREKQRHPICHSELFICGTKDSNELSVFQRKIQVISYDAFIKRYPKGLTRYMNDYDKVFYCRSGFHSRKEIYLDFIDWDQFYRHQETDFDALIAWVNTTCIQACSVQKHSKHIEVDESGADELVKEETVSENDVENSDIEDIYMPVESDESSDIINTEDDESINNTFSNKTPHKRGKSTPKLVTPVSGRRMTSGKRRCYKKHLEMTPLPLRYLFYDKSQLSPYQSARSRLHVSTVPMSLPCREREFSLIYSQVLNALEAGHGECIYISGPPGTGKTVTIKEVVRCLFQKVDEGEIDDFKYVEINGMRMIDPNHAYTLLWEALTEERVTSRHALMLLEKRFSQPSPNRVPCVVMIDELDQLVTKDQKLMYNFFNWPALQYSRLIVISIANTMDLPERMLTNKISSRLGLTRIGFSGYTFDQLQVIIRTRLQGIPGHLMDQDAIELASRKVSAISGDARRALDICRRAVEIAEISVTTNEKSSLINQDQIYHGKITMKTIQRAISELSASPVQTYLRTIPLAYKVFLISLMLKMKRSGLSTHKLGEIIDICLRMCKTTEKLCLQEFYRLSIDIDLNLINSAFALAEAGIIFFNTNGGKRQAHVQLKIAPQDVQMALQDDIDFRGILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7PGS4</accession>
    <name>M7PGS4_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01849</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873820.1">
        <property type="nucleotide sequence ID" value="XM_007875629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PGS4"/>
    <dbReference type="STRING" id="1069680.M7PGS4"/>
    <dbReference type="GeneID" id="19895543"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01849"/>
    <dbReference type="eggNOG" id="ENOG502QUDZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1180731_0_0_1"/>
    <dbReference type="OMA" id="RAWAYNK"/>
    <dbReference type="OrthoDB" id="359154at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_uL24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_uL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_uL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22682">
        <property type="entry name" value="Ribosomal_uL24m-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="4">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="224" mass="26878" checksum="FDC31156A8969ACC" modified="2013-05-29" version="1">MTKRIRCIEHIRRDIWSKFGNLRDERMGSRTSYNPQWIHPKDRIKFWNIAIGDQVQIITGKDKGLQGRVIEIDKKTNRLKVEGLKLCKKYLPRVLRTKETAKSVLEMPMFIHYSNVRLVGEIQGEEYGTKKLINIRHINKGKLFYNKDRKLLTWRRWIAGENKFLPWPTNLPKTEKEREQVYKDHRVDTKMNDVYAKTFVPVLYSPPFPLSLEDELRNKYSKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7PHG8</accession>
    <name>M7PHG8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diphthamide biosynthesis protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01660</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH = 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71239"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:17998"/>
            <dbReference type="Rhea" id="RHEA-COMP:18001"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:33723"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] = [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]</text>
            <dbReference type="Rhea" id="RHEA:71235"/>
            <dbReference type="Rhea" id="RHEA-COMP:17996"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:33751"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DPH3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873621.1">
        <property type="nucleotide sequence ID" value="XM_007875430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PHG8"/>
    <dbReference type="STRING" id="1069680.M7PHG8"/>
    <dbReference type="GeneID" id="19895354"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01660"/>
    <dbReference type="eggNOG" id="KOG2923">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155991_4_1_1"/>
    <dbReference type="OMA" id="LFTYPCP"/>
    <dbReference type="OrthoDB" id="66964at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.660.10:FF:000001">
        <property type="entry name" value="Diphthamide biosynthesis 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044248">
        <property type="entry name" value="DPH3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454:SF31">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454">
        <property type="entry name" value="DPH3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPH-type MB" evidence="8">
        <location>
            <begin position="3"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="79" mass="9349" checksum="9B38D93FAD51C7BB" modified="2013-05-29" version="1">MNIYDEIEIEDFTFDKELELYHYPCPCGDRFEISLDDLKEGENIAYCPSCSLMIRVIYDQNRFTQDDEELSVQSKLIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7PHK5</accession>
    <name>M7PHK5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial</fullName>
            <ecNumber evidence="15">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PNEG_01698</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Complex I is composed of about 40 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion inner membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
            <orientation evidence="15">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="15"/>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873661.1">
        <property type="nucleotide sequence ID" value="XM_007875470.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PHK5"/>
    <dbReference type="STRING" id="1069680.M7PHK5"/>
    <dbReference type="GeneID" id="19895392"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01698"/>
    <dbReference type="eggNOG" id="KOG2658">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014881_0_1_1"/>
    <dbReference type="OMA" id="QGDGKPH"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.230:FF:000001">
        <property type="entry name" value="Mitochondrial NADH dehydrogenase flavoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.600:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11540:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050837">
        <property type="entry name" value="ComplexI_51kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054765">
        <property type="entry name" value="SLBB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010120">
        <property type="entry name" value="PRK13596.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22461">
        <property type="entry name" value="SLBB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="Nqo1 FMN-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142984">
        <property type="entry name" value="Nqo1 middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="Nqo1C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 15" id="KW-0288">FMN</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="11 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 15" id="KW-0520">NAD</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding" evidence="17">
        <location>
            <begin position="373"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="466"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMR09939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="482" mass="53716" checksum="E4403BEB1F1A4D24" modified="2013-05-29" version="1">MPPHFLNRNTCISYFLQQSYRNFYSFAFVQELSKKTVYGGLRDYDRIFQNLYGRYDSSLKSAQKLGDWYKTKEILLKGHEWIISEIKASGLRGRGGAGFPSGLKWSFMNKPGFEKDTRARYLVINADEGEPGTCKDREIMRKEPHKLIEGCLVAGRAMNATVCYIYIRGEFYNEALVIQSAIDEAYKAGLIGKNACGSGYDFDIYIHRGAGAYICGEETSLIESLEGKQGKPRLKPPFPADVGLFGCPTTVANVETIAVAPTICRRGAAWFNSFGRERNSGTKLFCISGHVNNPCTVEEEMSIPLRDLIEKHCGGVKGGWDNLLGIIPGGSSVPILTKTQCENVLMDFDSLKDAQSGLGTAAVIVMDKSTDLVRAISRFSAFYKHESCGQCTPCREGTTWIYNIMKRFETGDAQLREIDMLWELTKEIEGHTICALGDAAAWPVQGLIRNFRSHIEDRIKKRSHNSIKTSENPSLTSSNNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7PHL4</accession>
    <name>M7PHL4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Superoxide dismutase</fullName>
            <ecNumber evidence="7">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_01707</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="7"/>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873671.1">
        <property type="nucleotide sequence ID" value="XM_007875480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PHL4"/>
    <dbReference type="STRING" id="1069680.M7PHL4"/>
    <dbReference type="GeneID" id="19895401"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01707"/>
    <dbReference type="eggNOG" id="KOG0876">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031625_2_0_1"/>
    <dbReference type="OMA" id="DSLINWD"/>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000004">
        <property type="entry name" value="Superoxide dismutase [Fe]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF6">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="8">
        <location>
            <begin position="24"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="9">
        <location>
            <begin position="119"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR09949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="220" mass="25926" checksum="A9F668F8D08BEF80" modified="2013-05-29" version="1">MLKSFKDLVLKKTIKNFRFFSHSKYVLPNLSFDYQALEPYLSGDLIELHYNQHHRAYVTNLNKTVEKYYEENESSLDSFINRLNLLTSIKFFAGGHINHSLYWENLLPNKQGGGQIINGPLVEAIKKEWKSVDEFIRIFNMQLAGIQGSGWAWLVKSPFSQRLSIQTTMNQDVVTQGKVILGIDAWEHSYYIQYLNNKTKYFENIWNVVNWKVMNQRFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7PHP2</accession>
    <name>M7PHP2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_01737</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA1 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873701.1">
        <property type="nucleotide sequence ID" value="XM_007875510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PHP2"/>
    <dbReference type="STRING" id="1069680.M7PHP2"/>
    <dbReference type="GeneID" id="19895431"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01737"/>
    <dbReference type="eggNOG" id="ENOG502S786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132216_1_0_1"/>
    <dbReference type="OMA" id="EVSNPWK"/>
    <dbReference type="OrthoDB" id="1920692at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017384">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17098:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17098">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE MWFE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15879">
        <property type="entry name" value="MWFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR09979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="72" mass="8222" checksum="BA94CF296E10EAF6" modified="2013-05-29" version="1">MPVPFEAVLPFGIIIGMFVVTGGLLTAVKQYRNEGYTPRYSVDRWDEQMMERDRRLTGSLRKQSDAARASKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7PHQ3</accession>
    <name>M7PHQ3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01747</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873711.1">
        <property type="nucleotide sequence ID" value="XM_007875520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PHQ3"/>
    <dbReference type="STRING" id="1069680.M7PHQ3"/>
    <dbReference type="GeneID" id="19895441"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01747"/>
    <dbReference type="eggNOG" id="KOG0938">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026996_5_2_1"/>
    <dbReference type="OMA" id="VWKIPRI"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09251">
        <property type="entry name" value="AP-2_Mu2_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14836">
        <property type="entry name" value="AP2_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043532">
        <property type="entry name" value="AP2_Mu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043512">
        <property type="entry name" value="Mu2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="10">
        <location>
            <begin position="169"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="432" mass="49906" checksum="27D98B06ACEECDF6" modified="2013-05-29" version="1">MILGIYFYNQRGEVLISRIYCQGLKRSVEDVFRIHVLFNRDIDSPINTIESNTFFHVKHENIYVVAVTRNNANTSLVFEFLYKIISLHEGYFKKFNEDSIKNNFTLIYELLDEVIDFGYPQNTDINSLKMYITANEFKSENDIKNNSSKITRHVMGTIFWRESDIKYRKNEAYLDIIENINVAMTANTTLRSDISGQIIMKSSLSGIPQCKIRFSDRVFINNSQLPITSTNTSKVEKTDYITLENCHFHQCVKLGSFNKDKSIIFIPPDGEFELMRYRVTENVRLPFLLFPIINEIGKTKVVYQLTIKASFSSDLSATDVIIKIPTPLNTANTNSRANRGKTKYESASNNIIWKIPKISGKMEYIFAAEATLKATSDDRHWSKPPISLNFSIPMFTGSGLHLKYLKISEKENYKSVKWVRYISKAGNYEVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M7PI16</accession>
    <name>M7PI16_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873323.1">
        <property type="nucleotide sequence ID" value="XM_007875132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PI16"/>
    <dbReference type="GeneID" id="19895085"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01388"/>
    <dbReference type="HOGENOM" id="CLU_950357_0_0_1"/>
    <dbReference type="OrthoDB" id="5379894at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="293" mass="33839" checksum="306481F7436E60B2" modified="2013-05-29" version="1">MKNIQFYIPPLSLGDDINKIRLDFTACYTVFYPDKNAISSWKKYDILKGNDLNLKLTTLWKNKHLNHDFINKLGQFISSAELWKQLYLRPIILQSIDKENDITLNLLPSESYPILHYPKSIAEKTSEHLNIVSRSLDRISKRSICTSLQGKLHSLKKISSQDSCFLTQELWNTVKKTILVRKTITEFKSALNPVYSSKSLQKNTDIKHNTDLSFFSINNNDSISYDNFLETKLLPIYSNSEVNSQNLLSYPTIIKQKENSPKTYDSSCNQFYCKKNTNKSISNKIETIILSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7PIM2</accession>
    <name>M7PIM2_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873494.1">
        <property type="nucleotide sequence ID" value="XM_007875303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PIM2"/>
    <dbReference type="STRING" id="1069680.M7PIM2"/>
    <dbReference type="GeneID" id="19895242"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01547"/>
    <dbReference type="eggNOG" id="ENOG502SVAG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_376876_0_0_1"/>
    <dbReference type="OrthoDB" id="5376259at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021750">
        <property type="entry name" value="Sid4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11778">
        <property type="entry name" value="SID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="382"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="582"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="736" mass="85121" checksum="EBFB3DBD11F9654A" modified="2013-05-29" version="1">MEKEESYGDDTWSTQYRWIQDSCESTIHPSINDMSFHNSNFLQHDINPIKTEKIRRLARLLDDTQMSTKTIKKEITLRTPYIASDSISNKKEYSQEIRGSASFLNSQLDAALSFDKHMNMHLNNKDSTSSKSSSSIPTLTANNDQSFLEPSLLESSGVSSCTAQSSSSITFSKKNRQETSPHPETQSRKSPNKSDVSSSFSWSSETVKEYLNEILEEIYQEKKEEIKLFHKSNHYKRFLGQNTGTTQENANFLENLIDKKGEASKKSENILDLMKEKIFLDTHDSNHYTNISENQNSLKLQIKDQSKPLSDENTHISPRKNETNNSYIQDSFVNASNHFLNKATPYRNSPSILNKKQTDDQKYTEIKSRQTNFETQYSYEDHNKYKEDIINIQNSLKQLASEYDRRGNMIDKLIDEFSALKSETKNQNDENALKISFDETKKHALFVEKDLDAARLEIADLKTICHDLIEALKINPQNIQKYYPSTPKAGNEESLKEKMMRWKTHLSPQFSPIQSTKPFCFSQNANTCDRKEPLHDLNIPANIQSPRQKIPSVSDKQKEISENFPVTQTPRTDNETLSNEKIYDLKMQLEKAEQEIERLRSIIPNVSHEHHTRPITPQNMPDAHKPISKAEKIYYSLQLYKIDKLCSNETSNLLKNILIQLNIPFDSLPETITSIRYQLQQSLRLREFAEEVHLSLYEGEPMDPKLVSKKCLGDMITKVDQLARSSRRRRIRRSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJX6</accession>
    <name>M7PJX6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00898</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 33 different proteins. The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and at least 46 different proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872809.1">
        <property type="nucleotide sequence ID" value="XM_007874618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJX6"/>
    <dbReference type="STRING" id="1069680.M7PJX6"/>
    <dbReference type="GeneID" id="19894596"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00898"/>
    <dbReference type="eggNOG" id="KOG0378">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060400_1_0_1"/>
    <dbReference type="OMA" id="GHIQLNL"/>
    <dbReference type="OrthoDB" id="1109245at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.740:FF:000001">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_eS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018199">
        <property type="entry name" value="Ribosomal_eS4_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00528">
        <property type="entry name" value="RIBOSOMAL_S4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="9">
        <location>
            <begin position="42"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00062825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR10749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="261" mass="29471" checksum="219BBCE101B376B2" modified="2013-05-29" version="1">MARGPRKHMKRINAPSHWLLDKLGGTYAPRPSPGPHKLRDCLPLIIFLRNRLKYALNNRETIAILMQRLIKVDGKVRTDHTYPAGFMDVISIEKTGENFRLVYDTKGRFTIHRITSTEAKYKLCKIKKIQLGSKAIPYAVTHDGRTIRYPDPAIRANDTVKFNLEFGKIEGFISFDVGKLAMVTGGRSKGRIGVIINRERHDGGFDIVHLKDALDRAFATRLSNVFIIGDAAGPWISLPKGKGIKLTISEERDKRRSLQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7PKL5</accession>
    <name>M7PKL5_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR10999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872497.1">
        <property type="nucleotide sequence ID" value="XM_007874306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PKL5"/>
    <dbReference type="STRING" id="1069680.M7PKL5"/>
    <dbReference type="GeneID" id="19894298"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00600"/>
    <dbReference type="eggNOG" id="KOG0104">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_5_0_1"/>
    <dbReference type="OMA" id="SRTPMIQ"/>
    <dbReference type="OrthoDB" id="10262720at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10230">
        <property type="entry name" value="ASKHA_NBD_HSP70_HYOU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF3">
        <property type="entry name" value="HYPOXIA UP-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004083007" evidence="5">
        <location>
            <begin position="27"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="893" mass="101485" checksum="A91C54A34F1F436B" modified="2013-05-29" version="1">MKRSFIFGVTSLLCFLFFSLSDLIMSVNGVVLAIDYGKEWIKGAIVKHGIPIEIVLTRDSKRKDMSVIAFNGDERFYGTRAADLLLRNQSSVFPSLKSLIGKSYDSREVREYLSLHKNIELVPSSKGSGVAFVQDNRTFTVEELTAMIFENYKTMAEDIAGQKITDVVITVPSFFTEIERHAILDAAEIAGLNVLSLVNEGYAIAMNYATTRIFSNESQYHIFYDMGAGSTTATYVSFKTLTLLNNKTLTLLKVLGVGYNRYFGGDTITWKLLEYLLQDFEISKRSYMRDSIRSNSRAIIKLFHESSRIKQILSINSEAHVMIENLHEGIDYNIKVSRDIFEGLLQGLADDIKKPIIDAVSMTSKPIRFVNSVVLAGGGARVPFVQKEIEALVGPKKVARSVNADEAAVLGAVFRGAGLSGRFRVKNIKSTDINLNSIFISYPDVDDASKIVTHSLFLKGSELNKNKTVTFSLLSDFDVVFSHVVGFKLPGTVFATLKISGFNDSINFLKNQYGDDYCENIITSITFRLDFSGLITVKRAFVECRSKIGDTSELLRESHKEYERKLFEEYNHVEYYDSYESTDDDAEDNNRTMPLDFEILYTSLNPQDKAFKVASRNMLLDLKEIDKKRIVRDEARNVLEAYVYNVQELLEIDEFIAFSTKEQREELLNTVKSVAEWLEKNGDVSTLDELTERKNSIKILEVPISERRADARERSIKVDELRRRIQGFMHFLNGLPIEKMKESSDTSTDDAKLAYEKILSKAGYGSDTKGNMHDVVEPGFRVEDVETYRKNVMKIEEWLNESVTAQDILKPWENPVLKVKDIMLKIWELEQTKENIRVMEQVYLRSRKYFKKNYTNAKPSVNESDPSVSTQQNVTLELPINTTLAESVIHTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7PKN3</accession>
    <name>M7PKN3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription elongation factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_03602</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ELOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872738.1">
        <property type="nucleotide sequence ID" value="XM_007874547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PKN3"/>
    <dbReference type="STRING" id="1069680.M7PKN3"/>
    <dbReference type="GeneID" id="19897289"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03602"/>
    <dbReference type="eggNOG" id="KOG3214">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105983_0_3_1"/>
    <dbReference type="OrthoDB" id="445983at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007808">
        <property type="entry name" value="Elf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038567">
        <property type="entry name" value="T_Elf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934:SF0">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05129">
        <property type="entry name" value="Zn_ribbon_Elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR11019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="89" mass="10189" checksum="C611BF7FEB8D0C5A" modified="2013-05-29" version="1">MGKRKTKMKRPKPKPRAPLDKTFNCLFCNHEKSTLICKVCGQTHQSIIHNLSAPVDIYSDWIDACDAVANKTNRNLTQELNLNNNDYNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>M7PLJ6</accession>
    <name>M7PLJ6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="14">ATP-PFK</shortName>
            <shortName evidence="14">Phosphofructokinase</shortName>
            <ecNumber evidence="14">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PNEG_00343</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14 15">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="14">Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14 15">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="14"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872216.1">
        <property type="nucleotide sequence ID" value="XM_007874025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PLJ6"/>
    <dbReference type="STRING" id="1069680.M7PLJ6"/>
    <dbReference type="GeneID" id="19894041"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00343"/>
    <dbReference type="eggNOG" id="KOG2440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011053_0_0_1"/>
    <dbReference type="OMA" id="EWQDQMC"/>
    <dbReference type="OrthoDB" id="537915at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000007">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000008">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03184">
        <property type="entry name" value="Phosphofructokinase_I_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040712">
        <property type="entry name" value="Pfk_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02478">
        <property type="entry name" value="6PF1K_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18468">
        <property type="entry name" value="Pfk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000533">
        <property type="entry name" value="ATP_PFK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 14 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 14 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase N-terminal" evidence="17">
        <location>
            <begin position="12"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="16">
        <location>
            <begin position="193"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="16">
        <location>
            <begin position="588"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal catalytic PFK domain 1" evidence="14">
        <location>
            <begin position="1"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal regulatory PFK domain 2" evidence="14">
        <location>
            <begin position="588"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="264"/>
            <end position="265"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="294"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="340"/>
            <end position="342"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="384"/>
            <end position="386"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="475"/>
            <end position="478"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="658"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="715"/>
            <end position="719"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="753"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="760"/>
            <end position="762"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="820"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="846"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="852"/>
            <end position="855"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="920"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMR11314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="949" mass="106290" checksum="83EF9C48B4119B42" modified="2013-05-29" version="1">MSNDEEFSLIDGLSSISFITYSLESYYKAIEFYCKIGFKEIFHYDRKEEHISRSLIDFSFKSDREIWLYILGGKEKELTIKIHFYHNDISKKSTKLTDSCQKENSDLSYTLIVASLTTIISRLDEINVPYDLYPNQTFPLQVTVKDPLGNFISFTEKISSFSHSQEKSAFLDPQREISLNNLDKKENVSKRRKIAVMTSGGDAPGMNAAVRSIVRMIIAMNCEAYFIYEGYKGLVEGGNMIKRAFWSDVRGWLSEGGTLIGTSRCISFKEKEGRLSAVKNLILNEISSLIICGGDGSLTGANIFRSEWPLLIEELISTNVLTRKQVENHMNLHIIGLVGSIDNDMASTDVTIGAYSSLHRICDSVDSIGATALSHSRAFVIEVMGRNCGWLALMAGISTGADLVFIPESPPLEDDWQSEICKTIKKQREMGKRKTVIIVAEGAIDKDLNPITATYLKELLVEKLNLDTRVTTLGHIQRGGVPCFYDRLLGTLQGVEAVHAILESTSDSPSQIIAINENKITRKCLSESVELTHSSAEAIQKKDFKKAMQLRNIDFSDYYQTYLYMTVFQKPPKLDNDSLILFSRENLRIAIIHVGAPAGGMNIATRSFVRYCLNRGHVPLAIYNGFQGLVSNDIVKELSWMEVEDWITRGGSEIGTNRDLPNTDIGMTALMFQKYNFNALMIVGGFEAFLSLLQLYKARVSYPAFRIPMICLPATISNNVPGTDFSLGTDTCLNTLIDYCDAVKQSANASHNRVFVVETQGGCCGYITVLAGLTVGSLVVYSPEDGINLKILTEDVKYLRKYFELQKGGNRRGKLILRNEKSSNIYTTDMISSIIVAEADHRFDVRTAIPGHVQQGNVPSPMDRVRSTRLAIKCVQFIEKMCYTNMHNDPSSAAVIGIRSSKVVTTPIEVLQHETDMEKRCPKTSWWFNIKDLINILSGRNVPFHLIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M7PLR6</accession>
    <name>M7PLR6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872305.1">
        <property type="nucleotide sequence ID" value="XM_007874114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PLR6"/>
    <dbReference type="STRING" id="1069680.M7PLR6"/>
    <dbReference type="GeneID" id="19894125"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00427"/>
    <dbReference type="eggNOG" id="ENOG502S0CB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085801_0_0_1"/>
    <dbReference type="OMA" id="IKFSRQN"/>
    <dbReference type="OrthoDB" id="37297at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02972">
        <property type="entry name" value="DsbA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875:SF2">
        <property type="entry name" value="ACR183CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875">
        <property type="entry name" value="OS09G0542200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="23892" checksum="56B8C0E5EDE04BC3" modified="2013-05-29" version="1">MTSNIISNFLCFGNLTSHHSLEFFLDFVCPFSKKLFKTVYEEFYPWVKKNKNDIKFIISLQVQPWHPSSTLVHEAVLAVSKLSENRTVDFIAELFEHQEEYFDTALVEESRLNTYKRLSLLAENAINIDRNKFLDLLHIENVKVGEKGYNVGNKVTTDLKLHIKNGRSRSVHVSPTVFYNGVMNDSISSSWTFDNWKEWYMKVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7PM77</accession>
    <name>M7PM77_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00023</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871874.1">
        <property type="nucleotide sequence ID" value="XM_007873683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PM77"/>
    <dbReference type="STRING" id="1069680.M7PM77"/>
    <dbReference type="GeneID" id="19893721"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00023"/>
    <dbReference type="eggNOG" id="KOG1651">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029507_0_1_1"/>
    <dbReference type="OMA" id="HRYDISW"/>
    <dbReference type="OrthoDB" id="446890at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140824">
        <property type="term" value="F:thioredoxin-dependent peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000010">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="7">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="158" mass="18367" checksum="E92D082469EE370F" modified="2013-05-29" version="1">MSFYNLKPTLNNQAYDFNILRNKVVLIVNVASKCGFTSQYSNLEKLYQKYKDSGFEILAFPCNQFGNQEPGTNEEIIEFCSRKYNVTFLIFDKIEVNGDNADPVYVFLKNQKKGLLNISRIKWNFEKFLINKTGEVVNRYSSFTKPENIACDIEKLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7PMG0</accession>
    <name>M7PMG0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial</fullName>
            <ecNumber evidence="20">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PNEG_00097</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 20">Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="18">Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 20">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 20">Mitochondrion inner membrane</location>
            <topology evidence="1 20">Peripheral membrane protein</topology>
            <orientation evidence="1 20">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="20"/>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871954.1">
        <property type="nucleotide sequence ID" value="XM_007873763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PMG0"/>
    <dbReference type="STRING" id="1069680.M7PMG0"/>
    <dbReference type="GeneID" id="19893795"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00097"/>
    <dbReference type="eggNOG" id="KOG2403">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014312_6_1_1"/>
    <dbReference type="OMA" id="PTGIWRM"/>
    <dbReference type="OrthoDB" id="71672at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000001">
        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.40:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000482">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.100:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit (SdhA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.40">
        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000171">
        <property type="entry name" value="SDHA_APRA_LASPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 20" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 18 20" id="KW-0274">FAD</keyword>
    <keyword evidence="6 18 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 20" id="KW-0813">Transport</keyword>
    <keyword evidence="5 20" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="21">
        <location>
            <begin position="61"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="22">
        <location>
            <begin position="511"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="66"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="455"/>
            <end position="456"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="19">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00059077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000171-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EMR11659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="646" mass="71308" checksum="261E669D525B055F" modified="2013-05-29" version="1">MLNKLCYLNTFLLNKDFFKIRVRRIHISKPVLKTISNQTIRSKQAKGFIGSKYSIVDHEYDVVVVGSGGAGLRAAFGLSEAGYSTACVTKLFPTRSHTVAAQGGINAALGNMTEDDWRWHMYDTVKGSDWLGDQDAIHYMCREAPRSVIELEHFGVPFSRTKDGKIYQRAFGGQSLNFGKGGQAYRCAAVADRTGHAILHALYGQSLKYNTNFFIEYFALDLLMEGDTCVGVIALSMEDGTIHRFNSHKTILATGGYGRAYFSCTSAHTCTGDGNAMVQRAGLPLSDLEMVQFHPTGIYGVGCLITEGSRGEGGYLLNSKGERFMERYAPTAKDLASRDVVSRSITIEIREGRGTGPLKDHIDLQLSHIPADILRERLPGISETVSIFCGIDVTKDPIPVLPTVHYNMGGIPTKFTGEVITLDNEGNDKVVPGLYAAGEAACVSVHGANRLGANSLLDIIVFGRACANHIKETLKPKTSCKPLSSDAGLASIQNLDKLRNANGSIPTAKIRLNMQRVMQTDVSVFRTEESLQKGVENIMKVDESFNDVKTTDRGLIWNTDLIETLELQNLLTNACQTAHSALARKESRGAHAREDYKERDDKNWMKHTLSWQDPITRKVTLRYRPVKSHTLDENECKSVPPSKRVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7PMS4</accession>
    <name>M7PMS4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00186</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872049.1">
        <property type="nucleotide sequence ID" value="XM_007873858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PMS4"/>
    <dbReference type="STRING" id="1069680.M7PMS4"/>
    <dbReference type="GeneID" id="19893884"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00186"/>
    <dbReference type="eggNOG" id="KOG0590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_435527_0_0_1"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="213"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR11754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="628" mass="71021" checksum="850CD8C4FF3C6729" modified="2013-05-29" version="1">MKEMPQKELLISSISLINASSPKKKEREDTEMITSSNSMKRLCQESNIFISSLDHHRSFSLNTGMGCLSEGFTELVEPFDHLSLCRSSDFLQELRPPPRISSAPYYFHGKYLKLNGLSKSLPPKPEVVYDFDFDKDPSTPNRHGISRSAAPSYTPSYTHTSNIPNHACAELGSGLKSKIFRNRSLSIGFQQLISREGIIKLKERYIYRNTHHGFRKKDIGSGATATVQVVSLKPGCHSTIESNGGDSGLFAVKTFRKKSRSERKEDYLKKLASEWTIQRRVNHPNVVRAVDLCLDDHTLTADSWCEIMEFCAAGDLHSLIKSMVDWTAEPEPKEMAPNLRNCLFKQLLRGVNYLHSEGIAHRDIKPENLLLNYNGILKITDFGTSDVLFNKNSPNGEKNIKKCHGICGSDAYIAPEVFMQKEYDGFKVDIWSCAIVYFCLTWGGTLFVKAIPGDKHYDNYLDAFKKFHAKFINSPDSTLYSNFISPSQTSIESSMTFSTSVSAVSNLIELSPLHSPVHSINGIKDEKLPAYAPFKHWKACAQHTIYRMLNPDPDERLTAEEVLASKFVQRIECCSSDKVQEVDSHGKVDVSNKDCFKQMETRVKHDHIPLDLLRKLKKSSFSINEKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7PMY8</accession>
    <name>M7PMY8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prefoldin subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00244</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872114.1">
        <property type="nucleotide sequence ID" value="XM_007873923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PMY8"/>
    <dbReference type="STRING" id="1069680.M7PMY8"/>
    <dbReference type="GeneID" id="19893942"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00244"/>
    <dbReference type="eggNOG" id="KOG3478">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125172_1_1_1"/>
    <dbReference type="OMA" id="VQTEFAQ"/>
    <dbReference type="OrthoDB" id="248120at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23161">
        <property type="entry name" value="Prefoldin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="4"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR11819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="10979" checksum="CC3E903298EE438B" modified="2013-05-29" version="1">MSLESKLEKKLNSQLQENKLVQKEFSILENEAVIYKLTGPVLVKQEKSEAILNVEKRLEYIETEIKRLETQIKKHNKTLEEQKLDITKLQNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWZ9</accession>
    <name>A0A0W4ZWZ9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">BRCA1-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_04299</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="KTW32895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873703.2">
        <property type="nucleotide sequence ID" value="XM_007875512.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWZ9"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZWZ9"/>
    <dbReference type="GeneID" id="19895433"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04299"/>
    <dbReference type="eggNOG" id="KOG0365">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0804">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SIECIDM"/>
    <dbReference type="OrthoDB" id="273556at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16457">
        <property type="entry name" value="RING-H2_BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12717">
        <property type="entry name" value="RRM_ETP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011422">
        <property type="entry name" value="BRAP2/ETP1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034931">
        <property type="entry name" value="ETP1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047243">
        <property type="entry name" value="RING-H2_BRAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007:SF7">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07576">
        <property type="entry name" value="BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="339"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="8">
        <location>
            <begin position="373"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="519"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KTW32895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="672" mass="78317" checksum="500AABE4FA709EF6" modified="2016-03-16" version="1">MTRFHQRIICFYPEASPWLEIYLERLFGASFTANFLYKIQQAKKLPKTDIFEQLPSEDFEYYQNIYKRAAEYSWSVKENSFERQTNIFSLNKGKRPVNNIIKGEDSRVEYIFVEWLDIEEKTGKKMKVKSQNEASFKDEKTSSNPPLNDKISRAQYIPFKEDNMNTQKHGIANFGFGVIHIYRDGKMLSTKEEWDGEELTSKDKVVAILAVPSYMTTSDFLGFVGEDVKNQVSHFRFIRTSAPNRYMVLLKFRQFKNAKAFYNTFNGKSFSSTEPEKCHTVFIKQILFQSKQIPKKELLSSTDDPFLPVFDIFETCQAASTLTIPIVSPTFGLRELPTCVVCLERMDASVTGLLTILCQHTFHCQCLSKWGENNCPVCRYSQQKDVLNAARINSQCSVCGLQKNLWICLICGHIGCGRYDLAHAYDHHINTGHCYVMDMETERIWDYVDDCYVHRLIQNKIDGNLLKFPSTSYCPDTEESVSEKNYLDMKKKLESMSLEYTYLLTSQLELQRIYYENKITAAMDKAKKAAEEEKQVKQEMDNLMKKFSELEINFNESQKKINDLKILNSQNGKKLEKSSELARRMEKEWKEEKLLNSTLMHRIEHLNIENNKIRLDSEGLKLKIEDLSDQLRDAMFFISSQKHLDTMNDDLKKELQAGTIFIPKKSKKKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZX46</accession>
    <name>A0A0W4ZX46_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase mitochondrial F1 complex assembly factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_04252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="KTW32946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613413.1">
        <property type="nucleotide sequence ID" value="XM_019757776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZX46"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZX46"/>
    <dbReference type="GeneID" id="30671552"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04252"/>
    <dbReference type="eggNOG" id="KOG1724">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3015">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TICYHAD"/>
    <dbReference type="OrthoDB" id="5322896at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3580.10">
        <property type="entry name" value="ATP12 ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011419">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023335">
        <property type="entry name" value="ATP12_ortho_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013:SF10">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2/ATP12 PROTEIN, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07542">
        <property type="entry name" value="ATP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160909">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KTW32946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="34397" checksum="62A008FBA309937B" modified="2016-03-16" version="1">MFCFFILKGLKHFISEYSAFTFFWNRKNRFYRRLIHNITTKLNYKDSSESFDLKKLLDGYQILLNNNPFKTPSGKIFEFPLRKHNLAYSVLLECRSFSPNFFEYNFLPLTSLSIRAIDMFSEKKDREQASSGLLKYLDTDTILSFASKNESGGDLLVLQKKMWEPLHEWAQKYWNVEILKTNNDFGIIMNPQPKKTKSLIKEWICNLDQWQFAALERAICLSKSFIIGAKMVATSNSPPIERLDVEKAFNLAQLEILFQIERWGKIDDSHDIEEKDIKRLLETVCTMLNDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZX47</accession>
    <name>A0A0W4ZX47_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Transcription initiation factor IIA subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_04249</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">TFIIA is a heterodimer composed of the large TOA1 and the small TOA2 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TFIIA subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="KTW32943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613410.1">
        <property type="nucleotide sequence ID" value="XM_019757773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZX47"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZX47"/>
    <dbReference type="GeneID" id="30671550"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04249"/>
    <dbReference type="OMA" id="QYYELYR"/>
    <dbReference type="OrthoDB" id="586585at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000979">
        <property type="term" value="F:RNA polymerase II core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10014">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10145">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.190:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIA subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.18.10:FF:000003">
        <property type="entry name" value="Transcription initiation factor IIA subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.190">
        <property type="entry name" value="Transcription factor IIA gamma subunit, alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009083">
        <property type="entry name" value="TFIIA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003194">
        <property type="entry name" value="TFIIA_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015871">
        <property type="entry name" value="TFIIA_gsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015872">
        <property type="entry name" value="TFIIA_gsu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10966">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02751">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02268">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009415">
        <property type="entry name" value="Hum_TFIIA_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit N-terminal" evidence="10">
        <location>
            <begin position="6"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit C-terminal" evidence="11">
        <location>
            <begin position="63"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KTW32943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="110" mass="12797" checksum="6C4018EE0F8786BF" modified="2016-03-16" version="1">MSNTRYYELYRRSSIGISLTDALDDLIREGQIPPQLAMKILLNFDKSITDNLTEKVKSRMTFRGHLDTYRFCDEVWTFIIKNPSFRLENDTMISDKIKIVACNSKKPGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M1FKB0</accession>
    <name>M1FKB0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 17">NADH-ubiquinone oxidoreductase chain 5</fullName>
            <ecNumber evidence="3 17">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">nad5</name>
    </gene>
    <organism>
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="21"/>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2013" name="FASEB J." volume="27" first="1962" last="1972">
            <title>Sequencing and characterization of the complete mitochondrial genomes of three Pneumocystis species provide new insights into divergence between human and rodent Pneumocystis.</title>
            <authorList>
                <person name="Ma L"/>
                <person name="Huang DW"/>
                <person name="Cuomo CA"/>
                <person name="Sykes S"/>
                <person name="Fantoni G"/>
                <person name="Das B"/>
                <person name="Sherman BT"/>
                <person name="Yang J"/>
                <person name="Huber C"/>
                <person name="Xia Y"/>
                <person name="Davey E"/>
                <person name="Kutty G"/>
                <person name="Bishop L"/>
                <person name="Sassi M"/>
                <person name="Lempicki RA Kovacs.JA."/>
            </authorList>
            <dbReference type="PubMed" id="23392351"/>
            <dbReference type="DOI" id="10.1096/fj.12-224444"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="function">
        <text evidence="17">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the complex I subunit 5 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="3 17"/>
    <dbReference type="EMBL" id="JX499144">
        <property type="protein sequence ID" value="AFR90413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_007475003.1">
        <property type="nucleotide sequence ID" value="NC_020332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M1FKB0"/>
    <dbReference type="STRING" id="1069680.M1FKB0"/>
    <dbReference type="GeneID" id="14657952"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010934">
        <property type="entry name" value="NADH_DH_su5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018393">
        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01974">
        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829:SF2">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06455">
        <property type="entry name" value="NADH5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01434">
        <property type="entry name" value="NADHDHGNASE5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 17 21" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 17" id="KW-0520">NAD</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 17" id="KW-0813">Transport</keyword>
    <keyword evidence="13 17" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal" evidence="19">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:quinone oxidoreductase/Mrp antiporter transmembrane" evidence="18">
        <location>
            <begin position="48"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="NADH dehydrogenase subunit 5 C-terminal" evidence="20">
        <location>
            <begin position="335"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF06455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="AFR90413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="551" mass="62453" checksum="73A217C41B7AFA82" modified="2013-05-01" version="1">MYLPVLTISFLVHCYSITYMKSDPHNPRFFSYLSLFTFFMLLLVSGDNYLILFIGWEGVGIMSFLLISFWYTRVQAVKSAMSAILYNRVGDLFFILGMAILLASVGSLKFSIVFSVVPSLNKTVLFLVGVCFLLAATGKSAQLGLHIWLPQAMEGPTPVSALIHAATMVTAGVYLLLRSSPLLEFNSYVLYLISGLGALTALVSGCIGLFQNDLKRIIAYSTCSQLGMMFVSIGLSKYSLALFHLINHAFFKALLFLSAGVIIHAFNDEQDLRRMGGLRPGMPLTYLFVLIGSMSLMAMPFLTGYYSKDVILEMSFERIEFYCLLVFVSVLTSSYSFKIIYYVFLSFPNGGHPKTYEKVHDVPSGMFLPLFFLSLCSIFGGYFTRELFIGIGSSALGNSLFTARESFIEFEIPVFFKILPMLLSILTVIVLFIIYHWNPWISSRGNLYRMFNQRMWLDLLFAKILQRVLSIGYYTSKYLDKGVLEYIGPWGFYKFFTYLTQSLSRADTHILRHYLIYMCLGLWGVILIVYSNIDYSIILIMLMSTLLIFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NHL8</accession>
    <name>M7NHL8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase delta subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_03503</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875595.1">
        <property type="nucleotide sequence ID" value="XM_007877404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NHL8"/>
    <dbReference type="STRING" id="1069680.M7NHL8"/>
    <dbReference type="GeneID" id="19897190"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03503"/>
    <dbReference type="eggNOG" id="ENOG502S6S5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047736_0_0_1"/>
    <dbReference type="OMA" id="GFIHNEN"/>
    <dbReference type="OrthoDB" id="514823at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904161">
        <property type="term" value="P:DNA synthesis involved in UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.20">
        <property type="entry name" value="DNA polymerase delta, p66 (Cdc27) subunit, wHTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019038">
        <property type="entry name" value="POLD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041913">
        <property type="entry name" value="POLD3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598:SF13">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09507">
        <property type="entry name" value="CDC27"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="385"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="385"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="414" mass="47329" checksum="21AFDB2DEA073884" modified="2013-05-29" version="1">MEQYLDKLETWIQSEQKVITYRFLSRYMGIHVEDSKQILFDYHKKCQESGKKCHAIYMISGYMNESIVNSGLDRSEKVESLPSNSQDESRICLESSTAKMKVFFLVKEEDIEYIKKKFDEITSIHVYSLELDLCKDSSTLSDAFFDSYNCIKYDEILSPEEMSKKYGIIHHMNVKVFPAGFQASNIDISSSKTTGILSEINSSQTINASSDSKEKTQTSMIRSFFDCSGHGTKSTLKSNKNPPKPIKRKSSFMDSFLNLGSNTESKPSSICSSNSVLPVKSLSNLENKESEELIVRRQQEINLLMAMMENQEKDDTNKSKESVSKAYNVDPIVKNEQVNLDKKRRGRRKVLKKVTSCDKKGYLVTKNEFVWESFSEDETAIPIKTKSDTEFKEGPEKNNPKTGETKITLFFSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NHX8</accession>
    <name>M7NHX8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydroxymethylglutaryl-CoA synthase</fullName>
            <shortName evidence="5">HMG-CoA synthase</shortName>
            <ecNumber evidence="5">2.3.3.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-hydroxy-3-methylglutaryl coenzyme A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_03342</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10188"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="5"/>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875421.1">
        <property type="nucleotide sequence ID" value="XM_007877230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NHX8"/>
    <dbReference type="STRING" id="1069680.M7NHX8"/>
    <dbReference type="GeneID" id="19897029"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03342"/>
    <dbReference type="eggNOG" id="KOG1393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008065_0_1_1"/>
    <dbReference type="OMA" id="DDAYNWI"/>
    <dbReference type="OrthoDB" id="1269963at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000008">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000590">
        <property type="entry name" value="HMG_CoA_synt_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010122">
        <property type="entry name" value="HMG_CoA_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01833">
        <property type="entry name" value="HMG-CoA-S_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01226">
        <property type="entry name" value="HMG_COA_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="6">
        <location>
            <begin position="7"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="7">
        <location>
            <begin position="178"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="453" mass="51051" checksum="E5BC11A648E36724" modified="2013-05-29" version="1">MRILESPKNVGIKAMEIYFPSLCVLQEDLEKYDQVSPGKYTIGLGQTMMGFCDDREDIYSLCLTTVSRLIKNYNVDVNNIGRLEVGTETLIDKSKSVKTVLMQLFSPNYDIEGIDTINACYGGTNAFFNAVNWIQSENWDGRDAIVVAGDIALYSRGNARPTGGAGCVAMIIGKDAPIVLDSGLRGTCMDHVYDFYKPDFTSEYPIVDGHYSISCYTRAIDYSYKAYNMKYSIRRSLGDTNCNTAYSLPIDRFDYCIFHSPTCKSVQKAYARLMYNDFIENQDHPEFESVKHLAGIEYQSSLVDKDLEKQFINLSKKRFESRVGIGLDVSKNVGNMYTASLYGCLASLLSNVLPSKLVGKRIGAYSYGSGLAATFFSFTIHDDVSYIVKILDLKTKLANRKVLSPVEFERMISLREQAYLAKDYIPHGDISNIALNAYYLVKIDEKYRREYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NI21</accession>
    <name>M7NI21_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_03378</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875462.1">
        <property type="nucleotide sequence ID" value="XM_007877271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NI21"/>
    <dbReference type="STRING" id="1069680.M7NI21"/>
    <dbReference type="GeneID" id="19897065"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03378"/>
    <dbReference type="eggNOG" id="KOG0251">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014248_1_0_1"/>
    <dbReference type="OMA" id="TKATPGQ"/>
    <dbReference type="OrthoDB" id="44015at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16988">
        <property type="entry name" value="ANTH_N_YAP180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.150:FF:000004">
        <property type="entry name" value="ENTH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
        <property type="entry name" value="ANTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014712">
        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF5">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN LAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="4">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="311"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="575"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="576"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="605" mass="68694" checksum="2F277096CF19DBB4" modified="2013-05-29" version="1">MPYKALSYQKAVNGATKIKLAAPKQKYLERILGATYSGDIALFEVFSALFSRLREPSWTIVFKSLIVIHIMIRDGSRDITLQYLSNNMRYFSIKELFGDTSFFSYDSGGLLFLGELAISQQSRNIQNYGLYLQEKIQSFKDVQVDYVYAKSSKTIEGRLRRLTVAKGLLREVEIVQRQIDTLLCCKFLEDGLTNNITIVAFRLLIGDLLSLFQVINEGVINVLEHYFEMSRYDAEKALEIYKKFVKQTANVSDYLSFACRMETLTCIEVPNIKHAPVGLSRALQEYLDDKNFEKNRLQYIENKNALDSSKKKANLTVPSAKTSSKKKTTDTQSLSGNTQKQNSNNINLIDFFSSIENEQAFMFPSAPMKNIAYEPSNFSGIQPTQPIQPIQTVVNSAPEEQSIVSFPQNVPSQMQPQVQVSYGLYNQYSSAFHPNNAPYQSTQPIMQNPNSFQASFPINQKQDYNSIYPMQANFSGSAYGIYHMQSNAHPFNQTHHFNQIVPSPVLETNNSSINHTNPFHRPPLSMNTEFEHQRTLLTNQFPPTITSTQFPPPTNPFSKSYDNVTTPFLDPKARTVRQNASTLPFAQKPRTNPFSNDNLPSEHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJQ7</accession>
    <name>M7NJQ7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874649.1">
        <property type="nucleotide sequence ID" value="XM_007876458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJQ7"/>
    <dbReference type="STRING" id="1069680.M7NJQ7"/>
    <dbReference type="GeneID" id="19896321"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02630"/>
    <dbReference type="eggNOG" id="KOG2208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002477_0_0_1"/>
    <dbReference type="OMA" id="ANTRILW"/>
    <dbReference type="OrthoDB" id="271862at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22453">
        <property type="entry name" value="KH-I_MUG60_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02394">
        <property type="entry name" value="KH-I_Vigilin_rpt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056553">
        <property type="entry name" value="KH_Mug60-KHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF76">
        <property type="entry name" value="KH DOMAIN-CONTAINING PROTEIN YLL032C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24563">
        <property type="entry name" value="KH_Mug60-KHD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="233"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="461"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="529"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="614"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="811" mass="93484" checksum="B5E13505DEF77776" modified="2013-05-29" version="1">MTERVRHVPQKIHLAFALPPSFPATPNLEKCYYSFSRHSLNLYPAAGLSPNTNYHNHDPYVLRMAQHCWEASGMVEAVHAVQSLPPLSVLDEEDAAFVQIFLSGESNHVAETREKIFSECLPQRQACIAVSRYLLLSEEGVIDPQLSTRFDEIALDTGTSIYILKSDVSLLTMHTLISSKTETNLGGISITLPIYKKIMLPDDVTLSVLVSGDVASLEYALVKIFVHLDMLMGMQVKKLEINPRFHPLICGRKRSNLKNIMEETFTNIYMPMPFANVLSIRRHLPPLVSDEIYVTGQRENIINAEKRIYAAYQSFTLISKTIVIVASKKDWLLIKKLDDIKNIMDNNVSYIKFPMLGSQNIEIDVFSTHDHLIDNTIDSFISLLSDYYNATYWIFPRSNQQNYELLFTDLEIQKILLEITKKHPVEIIYKHGCFEIAGMKDEIKKVVRSISKIPNVQNRPQQIRFTVEFSSKYHEFIQGKKEGKINAIRKHVGVIVELHTFSNRSFYIDIIAENLEQAMHCLSMLEDEFPTEITFYIPEEYHRRMIGIRGNTIQSVMRQYGVFVKFSNTSALAAPGHHNYPDDNVLVRCPAKNAANLIELKETLMNMANYKDKDSISENIYVPCVYHKMLKNRSNKIIHNVEQSTNCVIRFPNNELHKDYITVIGSEAQVPRAIDMIMKSIIDEYKFCIVSSKALDNIIESKEYKFWVVEYIRKKYCIEVTSFPNNVNTNAYPNVRYHVFRLSFPKSQLSYLDLAINVIFRYFMQHRIPLHLSFKEDAGQVSRLKAYDSFSHFNSMLFPPVSASTGKFWEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJZ7</accession>
    <name>M7NJZ7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-mRNA polyadenylation factor Fip1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02728</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874754.1">
        <property type="nucleotide sequence ID" value="XM_007876563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJZ7"/>
    <dbReference type="STRING" id="1069680.M7NJZ7"/>
    <dbReference type="GeneID" id="19896419"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02728"/>
    <dbReference type="eggNOG" id="KOG1049">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_723844_0_0_1"/>
    <dbReference type="OrthoDB" id="1917198at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007854">
        <property type="entry name" value="Fip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051187">
        <property type="entry name" value="Pre-mRNA_3'-end_processing_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484">
        <property type="entry name" value="FIP1-LIKE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484:SF0">
        <property type="entry name" value="PRE-MRNA 3'-END-PROCESSING FACTOR FIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05182">
        <property type="entry name" value="Fip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA polyadenylation factor Fip1" evidence="6">
        <location>
            <begin position="134"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="317"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="382" mass="42250" checksum="03C332AF6F3B71CA" modified="2013-05-29" version="1">MADDEGDKYLYGEEDEYKTSIGDEVLKNGKNGSPVFGKNVEMQDVSKNKENGSEEEEEGESDSDIEFVIETKPGQRAEPLSRPAPYSSVKISAPTKGIDKVFIASSKQEPPSTKPPGVDVDYVAEWNGKPLYQLDVESFAEKPWRKPGADITDYFNYGFDEFTWMAYCAKQTGIRRDFTPQKIMQMMEHMSGTDMISMAPNMQVMMATGGFPGMQNISGMKPDIVPMMGMGMSDMSGFVMNMGQMGFQQFPPGLNSMTPESQLGQAVQGKQMPYSHNLYNVQSYGGYNQMQPQYGSQMQGLKSMSSVSKAHNTDGVKVLSNERVQSSVNYKQESSLASSKESHESIESISSTSQNRSSGRSNMQNRNKSSSLSNIGKSRSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NKW4</accession>
    <name>M7NKW4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02242</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874228.1">
        <property type="nucleotide sequence ID" value="XM_007876037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NKW4"/>
    <dbReference type="STRING" id="1069680.M7NKW4"/>
    <dbReference type="GeneID" id="19895935"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02242"/>
    <dbReference type="eggNOG" id="ENOG502S254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_11_0_1"/>
    <dbReference type="OMA" id="ESINACA"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008413">
        <property type="term" value="F:8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042262">
        <property type="term" value="P:DNA protection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03427">
        <property type="entry name" value="NUDIX_MTH1_Nudt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43758">
        <property type="entry name" value="7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43758:SF2">
        <property type="entry name" value="OXIDIZED PURINE NUCLEOSIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="6">
        <location>
            <begin position="10"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="204" mass="23924" checksum="C092433A22CB9219" modified="2013-05-29" version="1">MNCSELPHIETKQYTLVIPYDAKNTHVLLGLKKRGFGVGKHYYVYLIFKSVLTLIRWNGFGGKVMENESINACAARELKEECGIEDAVLEKMAILLLKWERSTCVTEIHVYKATQFLDKPIESEEMIPQWFSVDPSAHNSIPYDHMWEEARIWYPEFHRGRKFVFNVLFKGDIDISDNTPLIIHYHLTPVENIHDYTYTNHLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NL51</accession>
    <name>M7NL51_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitobiosyldiphosphodolichol beta-mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.142</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Beta-1,4-mannosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">GDP-mannose-dolichol diphosphochitobiose mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PNEG_02334</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an N,N'-diacetylchitobiosyl-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13865"/>
            <dbReference type="Rhea" id="RHEA-COMP:19510"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57269"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="EC" id="2.4.1.142"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:13866"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.142" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874337.1">
        <property type="nucleotide sequence ID" value="XM_007876146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NL51"/>
    <dbReference type="STRING" id="1069680.M7NL51"/>
    <dbReference type="GeneID" id="19896027"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02334"/>
    <dbReference type="eggNOG" id="KOG2941">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012079_0_0_1"/>
    <dbReference type="OMA" id="CKLIIDW"/>
    <dbReference type="OrthoDB" id="614844at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004578">
        <property type="term" value="F:chitobiosyldiphosphodolichol beta-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026051">
        <property type="entry name" value="ALG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036">
        <property type="entry name" value="BETA1,4 MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036:SF0">
        <property type="entry name" value="CHITOBIOSYLDIPHOSPHODOLICHOL BETA-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="17">
        <location>
            <begin position="254"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMR09388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="442" mass="50977" checksum="9796E365DEDA45EF" modified="2013-05-29" version="1">MIIWYIILFFAGFGLQKLLRSRYKNNRKISQRSICLVALGDLGRSPRMQYHALSFSKHGFEVNLVGYQGSLLFPNIQESKNIHIIYIPFEPKFLNKCNLLPFLLSGPIKVFFQTFFLFFALFYLPQSTEYLVLQNPPSIPSFGVTRLICSMRSIKLIIDWHNLGYSVLSLKLGSKHILTLLYKWYERVFGNCADIHFTVSYAMTTFLQEKWKYKSPIYTLHDRPPMHFKPLDNLEKSSFLSTFVHTYDFDISNEKTKLLVSSTSWTADEDFSILLEAFITFDRMNTILSKNREPLSILAIITGKGPLRKFYEQKIKNLNLKYVKIVTAWLDAKDYPRFIGSADLGICLHTSSSGLDLPMKIVDMFGCGIPVCAIESPALPELVKDGKNGIIFSSSNQLANSLKKLFYSHEELAKLKKGAMEETRYRWHNEWDAKIAPLFKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLL5</accession>
    <name>M7NLL5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GTP-binding protein yptV4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_03527</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875619.1">
        <property type="nucleotide sequence ID" value="XM_007877428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLL5"/>
    <dbReference type="STRING" id="1069680.M7NLL5"/>
    <dbReference type="GeneID" id="19897214"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03527"/>
    <dbReference type="eggNOG" id="KOG0098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_23_1_1"/>
    <dbReference type="OMA" id="TNATHAC"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001129">
        <property type="entry name" value="ras-related protein Rab-44 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="23756" checksum="96D204DD85A6012E" modified="2013-05-29" version="1">MDDWVYTIKFVIIGDSGVGKSNLMRRMMNNQYLERHDATIGIEWGARIIDIDGVKMKLQLWDTAGQETFHAMTRNYYRGSSGALLVYDITRRETFEHMAVWLEDLKMYGSSNISIALVGNKADLENTFREVGLEEARKWANEKGICIFAEVSAKTGDQVNESFMRVARDIYGKILSNQLDVNDRLNGIKVRRKNLLDMDVKQGKRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLQ7</accession>
    <name>M7NLQ7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02182</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cclA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874165.1">
        <property type="nucleotide sequence ID" value="XM_007875974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLQ7"/>
    <dbReference type="STRING" id="1069680.M7NLQ7"/>
    <dbReference type="GeneID" id="19895875"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02182"/>
    <dbReference type="eggNOG" id="KOG2626">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_380890_0_0_1"/>
    <dbReference type="OMA" id="CATCSRW"/>
    <dbReference type="OrthoDB" id="10266026at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048189">
        <property type="term" value="C:Lid2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12872">
        <property type="entry name" value="SPRY_Ash2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037353">
        <property type="entry name" value="ASH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049455">
        <property type="entry name" value="ASH2-like_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053835">
        <property type="entry name" value="ASH2L-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598">
        <property type="entry name" value="SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598:SF0">
        <property type="entry name" value="SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21198">
        <property type="entry name" value="ASH2L-like_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21257">
        <property type="entry name" value="PHD_ash2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="8">
        <location>
            <begin position="405"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="314"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="314"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="734" mass="84856" checksum="67F25EADDA7976BC" modified="2013-05-29" version="1">MEESISENPNSKMTIYSNEKNININCERQLNDKILSEEKINQTTMKIEHIIKDIPLKPILNYNPDELRWNSTHTINLEHVYCYCAQDRTLDEPDFQCRVCKNFFHARCFRSPLKEVLPFLINYTLVCSLCSSTNTEEFHRSIASWKAICGCVIANLTSQKIISDHPEWTKDMISSKNHLELTRLEYFFTKKADIVPFLENPFNWKILCIDKEKASSWQSTLGNLLLSSKDTFRAQDEGNRSQNSPYSLIDTNLFQFRSMYTSGSHKLTLNTSRKRQNSIYHDENIHTKFLKNSSTISNSIENISSNIKKENLENKKDIKESRERKETWKKKESHTKKKDKVSDTNISNMSILPRIRPPPYRPSDFNSTPRLPTFIRVENNNINQDFYSLTDQPFNRKAFRYLPCEATPLMPNIMYRQIELPPYRARISWNDTSQHVFLDKDGMTATTDKGFRMARANVCMNEGDWYFEFIIERGNGDQGGFVRIGIARREASLDAPVGFDGYSYALRDKGGQKVHMSRPRDFMESFGTGDVIGFHVSFPKTTSKNSCILKSDIFRDRIPIRYKGQLYFEQLEYIPSKEMEDLMNPASNAVKSATLPSIIKNSFIKVYKNGKFMGTAFQDLYAFLPPNSQTIQAQDINDGMLGYYPAVSMYRGGIVRLNFGPLFKYPPKDIPLGSVVIPLFERYTEQIAEDIVWDLVDEIDLSFSSEIMDSLSAIRTKETTNSSEISEIKEIEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLQ9</accession>
    <name>M7NLQ9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PWI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_03570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875663.1">
        <property type="nucleotide sequence ID" value="XM_007877472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLQ9"/>
    <dbReference type="STRING" id="1069680.M7NLQ9"/>
    <dbReference type="GeneID" id="19897257"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03570"/>
    <dbReference type="eggNOG" id="KOG2253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009938_0_0_1"/>
    <dbReference type="OMA" id="DGCVNKK"/>
    <dbReference type="OrthoDB" id="6275295at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12446">
        <property type="entry name" value="RRM_RBM25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052768">
        <property type="entry name" value="RBM25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034268">
        <property type="entry name" value="RBM25_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806">
        <property type="entry name" value="RBM25 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806:SF4">
        <property type="entry name" value="RNA-BINDING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="107"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="PWI" evidence="5">
        <location>
            <begin position="609"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="227"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="391"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="697" mass="80681" checksum="955CC0EB42BDBB04" modified="2013-05-29" version="1">MYCPPQGPYGTNPLYGYQGYQTYQQNLQAPPGYVPNAVQSQSVGYGLPTNISKIDFNAPVIHFGTNVNQMKPQAAVITSAPVLVSRTAAVRDTPSLLQPPTVEQQLRTLFICSIPDYLDDFWIDKILKSVAKLKEWKRASNATGSLRNFGFAEYDDPEHVQRAIIALENLVIPPLKGDGEGSKIMVVVDQKTREYLDEWNETRENKNPQRDRSLIMQAKSNLTKVLEDFKDPNKRDPKKTSSEDSFRDLQASESKDTSKVVTVTLNVDDELEDIPVEHREAVAREISSFRERSERREHEKLKREEETERRRLELERMSGLFVSSKFASQSNNSISQRARNNNIQPPNYSDDLYGQMSKDYQKSITFVSKESNGYVQSHEDELDDTRTCEEIEKERRNRKQKELEAAFQEREKRWLNREKSRTSALEREMNRDKEEAFREARDREIMSRRLAEWNDDLEAEAGVEEYYKDRSSWLRHRAIFRTREMEMDARDRALEEREEVEKSKASTNVDFLSKKQAAEYKHAESGISKDSGIGPIRLTLGSAKKQTDVPKRVVSEVEKLLEDDDDHYTGNKKPVLLPLEYDDTEAAEDDESKIRRIKEIVASVPSEKEGLWSWSIKWDRLTESIIEEKIQPFITKKIVEYVGVQEDDLIKFILDHLRKKGSAEELAKELEMAMDEEAELFVNKVYRYVIVISEACI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLW2</accession>
    <name>M7NLW2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peptidase M16 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_01848</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873819.1">
        <property type="nucleotide sequence ID" value="XM_007875628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLW2"/>
    <dbReference type="STRING" id="1069680.M7NLW2"/>
    <dbReference type="MEROPS" id="M16.A09"/>
    <dbReference type="GeneID" id="19895542"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01848"/>
    <dbReference type="eggNOG" id="KOG0959">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004639_1_1_1"/>
    <dbReference type="OMA" id="WIFDEMK"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000005">
        <property type="entry name" value="nardilysin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000004">
        <property type="entry name" value="Putative insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082450" description="Peptidase M16 N-terminal domain-containing protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="9">
        <location>
            <begin position="67"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="10">
        <location>
            <begin position="231"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="11">
        <location>
            <begin position="412"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="12">
        <location>
            <begin position="801"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR09658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1068" mass="124291" checksum="FF39683C8DA9131F" modified="2013-05-29" version="1">MWSYFIFFSLIFLLKTESHIIQHNKTDHILYKRATTATLLTENIKKPEGDHYSYRLIQLSNGLKTLLISYPDSLSAGAALDVKVGHFSDPDDIPGVAHFCEHLLFMGTKKYPGEDDFSEYLLTHAGTYNAYTSTEDTNYFFSVEPKSFEKALDMFSQLFISPLILKRSVEREAHAVDLEHKKNLQNDAWRLFQLEKSISNPKSPYSKFGTGDYVTLVENTRKKGIDIASVVSKFFSTYYSSNLMKLVIFSSESLDNLEKLAVKYFTDIPNKNLEVPKFTEKPFGADVIGKQYWYKPIADSNSIELVFPIDTQRMFYKSSPSDYLRHFLDHRSYGSVFYTLNQRGWITDISVYSEYIVSETDALRINIGLTEIGLDNYEDILGLVFQFLRMLRDNTPNEDYFKDLIKIDDVSFRFKDQPKLMSYASHLASVMQLPYIEDVDLLRSSYLSEYDHKQFAKLLSVLRDDNYFLTITSKTKPGYWDLREPWYGSEYKVDVFSQTLLEKTRKDDLNISLKFPEKNIFIPELFIRANVSTHKKTKPTLMYNDTRLRYWYKEDDTFSIPKTFISALIKIPDYSSSPFETAHSKIYLDMLINHVSTQHYNAIVAGYSLTISAIDIGIYLSIYGFSDKILLLLDKVIESMRLYTPSLASFMSSRQKYLYMYEYDKVSMPYSKVSQVSLAFHDPLYWPSSEMLYAINSTTYEDVQVFHSRRFSSVFTEVLAVGLLSNSTKDLLEIYFKALSPKKQYPYQILPSRSYIFKEGSNYIYEMSLLNPQEVNSAILYSLQVGSSKDSKLIALLNVLFSLIRSRVFNQLRTEEQLSYVVRVSSYTSTALMSFFFVLQSLRDPFYLEQRINAFLYRFAAFIDTITDEQLKSVVNTLLPLFSGRYTSLPKESGVYLASIVSGFYDFDIRKKIYRSLKGLTKEDLKDYFYNYFYPDSATRKKLSIHLKSQTLESVSVRDFSPRRLQYYFKCNGLDISLEDLSDLIESSHLLVDFEKALKKFFTNKYPHKDVSEIVSQAFKYLKELYTKLKKDAIKNYDAQHFTDLTTFKNSLKLSPVPLPVMKWSSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLZ7</accession>
    <name>M7NLZ7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_03391</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08222.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613284.1">
        <property type="nucleotide sequence ID" value="XM_019757756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLZ7"/>
    <dbReference type="STRING" id="1069680.M7NLZ7"/>
    <dbReference type="GeneID" id="19897078"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03391"/>
    <dbReference type="eggNOG" id="KOG0570">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065214_0_1_1"/>
    <dbReference type="OMA" id="IHDSYSM"/>
    <dbReference type="OrthoDB" id="10253553at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009244">
        <property type="entry name" value="Mediatior_Med7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044888">
        <property type="entry name" value="Mediatior_Med7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428:SF11">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05983">
        <property type="entry name" value="Med7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0010">Activator</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08222.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="217" mass="25353" checksum="F5E55B040797CE6D" modified="2016-03-16" version="2">MQDSALETELSSTFPPPPRHYKLFTKENLDAFKEKKYDFIRDLDNLGVYDATNTCSPKLERFFTPPKAPTKGFYRCFHEQWKIPDELPSLSDFGIQELFDSSNGPLCAQKRVNELKKMLKSLLLNFLELVGIMSIAPEQFVEKVEHIRIILLNMHHLINEYRPHQARHTLCRLVEKQVQEEKEQLLACEDVCNDIKDTIHAYKSILEFNPDQQLSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M7NM98</accession>
    <name>M7NM98_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_01962</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873939.1">
        <property type="nucleotide sequence ID" value="XM_007875748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NM98"/>
    <dbReference type="STRING" id="1069680.M7NM98"/>
    <dbReference type="GeneID" id="19895656"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01962"/>
    <dbReference type="eggNOG" id="KOG0933">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001042_9_0_1"/>
    <dbReference type="OMA" id="THNKIAM"/>
    <dbReference type="OrthoDB" id="10255539at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034506">
        <property type="term" value="C:chromosome, centromeric core domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990814">
        <property type="term" value="F:DNA/DNA annealing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003680">
        <property type="term" value="F:minor groove of adenine-thymine-rich DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903342">
        <property type="term" value="P:negative regulation of meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070550">
        <property type="term" value="P:rDNA chromatin condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070058">
        <property type="term" value="P:tRNA gene clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03273">
        <property type="entry name" value="ABC_SMC2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000278">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000385">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027120">
        <property type="entry name" value="Smc2_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="13">
        <location>
            <begin position="521"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="246"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="319"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="747"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR09778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1174" mass="134279" checksum="FD700995CB5B19A6" modified="2013-05-29" version="1">MYLSEIIIDGFKSYAHRTVISGLDTCFNAITGPNGSGKSNILDAICFVLGITNMSTVRAQNLQDLIYKRGQAGITKASVTVIFDNSDSKKSPIGFEDHPQITVTRQIIMGGMSKYLINGHRAQQQTVQNLFHSVQLNINNPNFLIMQGRITKVLNMKSMEILSMIEEAAGTRMFEERKDKAIRTITKKDRKVEEINALLAEEIEPKLEKLRQEKKAFLEYQQIQSDVERFTKLVVAYDYLKSNDKLTEFEIDLQNKNNRVIDLESSIKTRKYEVTSIEENIKTLKEEKEIQLRKGGNFQKLENDFKDCSHELVRLNTLIELKEGSLAEEKIKLAKLEETSKELHISLEEKKRHFHSIEEFYNKLKIEFDAKNDEMNRKEELLQTLSTGIAAREGQTNNYTDQLQEARNNLNRAMTEEKQIILKMDHFQKRIIEIGPKANKAQKENEVLLNGLEKMKQELKVIEEKISALGLQNNINDNFYKEKSDYETKIASLTSRYENLKRNVANIDFTYSSPSPEFDHLKVLGFVAQLFTLDEKNYNASMALEVCAGGRLYNVVVEDEIVAAQLLQHGRLKKRVTIIPLSKISSVKIPVEKIDMAQKRAPGKVNLALDLINYGKNVKAAMEYVFGSTVICENAEIAKQITFDPNLSLKSITLNGDIYDPSGTLSGGSSTSSNGVLVQLQKLNEVKNELNLYNNKLLEINTFLEKNKERLDKISSLKKNYDLKSHEIKLTEKQISLNSSSKVMNEIKELESNIELCKTTLAEVKLKQEQYKKDIKEIEKDMEEFKNNKDSKLLQLQKTLEKLKSVVEKQSENVKLECKKYQSLKLEKEQLEGDLVIIQKQLKENNALISSQNSEINTLKFEQAQAKENYEKLQRVLENERAKLTGYDKEFKHLENAMKIKTSYISEANLELQSLRHEINRLNKDKQSTLQSLNQMEAQYEWISDEKENFGKPSTAFDFSDYDIKKCKASLNSLTERFQALKKKINPKVINMIDGVEKKENALKTMVKTIHKDKRKIEDTIKSLEDYKMEALQRTWKKVNSDFGKIFSDLLPGSFAKLVPLDKKTIADGLEIKVCLGKVWKDSLAELSGGQRSLVALSLIMSLLQFKPAPMYILDEVDAALDLSHTQNIGHLIKTKFKGAQFIVVSLKDGMFSNANRIFTTKFVHGHGSVVETM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMH0</accession>
    <name>M7NMH0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamate-rich WD repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02049</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874029.1">
        <property type="nucleotide sequence ID" value="XM_007875838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMH0"/>
    <dbReference type="STRING" id="1069680.M7NMH0"/>
    <dbReference type="GeneID" id="19895743"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02049"/>
    <dbReference type="eggNOG" id="KOG0302">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025272_1_1_1"/>
    <dbReference type="OMA" id="RHWKPNA"/>
    <dbReference type="OrthoDB" id="2161379at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051972">
        <property type="entry name" value="Glutamate-rich_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903:SF1">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="5">
        <location>
            <begin position="74"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="275"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="328"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="370"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00040876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="466" mass="53016" checksum="D399DFFAD12BE069" modified="2013-05-29" version="1">MHKRQRLESSKENIPFENMIKSSEIKKNDDSIGEFEDPWEDEIESEEYIEDINEDPMNEEVKVYLPSSRSLKEDEVLEPDQSAYEMLHSINVQWPYLSFDILKDNLGLRTNYPVTVYLVSGTQADIKKDNNITVIKLSHLCRTQYDDDSIDSNDSDIDEDPILEYRSLPTFGTTNRIRAFYKEGESYFVASFSETGKVHIWDVAPHLLSINNPGVSVAKKYNSPIYTVLNHKVEGYAIDWNTLSSHNFLISGDNNGFIYLTSLSEASWFTEKTPFLGHISSVEDLVWSPSERNVFASASTDGTVKIWDIRNKRHKPALSADLHPGVDINVISWNKNVLYLMATGADDGKFNIWDLRTFQSSSIPSFIASFSWHTAPITSIEWHPSEKSVISVSDKNHVSLWDLSVEVDNESQVSKKTDDLDHIPNQLMFIHMGGKDIKEAHWHHQIPGCVVSTSSTGIQVFKTISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMJ9</accession>
    <name>M7NMJ9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Conserved oligomeric Golgi complex subunit 6</fullName>
            <shortName evidence="10">COG complex subunit 6</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Component of oligomeric Golgi complex 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_03277</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the conserved oligomeric Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the COG6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875350.1">
        <property type="nucleotide sequence ID" value="XM_007877159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMJ9"/>
    <dbReference type="STRING" id="1069680.M7NMJ9"/>
    <dbReference type="GeneID" id="19896964"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03277"/>
    <dbReference type="eggNOG" id="KOG3758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011361_1_0_1"/>
    <dbReference type="OMA" id="HSCLDFF"/>
    <dbReference type="OrthoDB" id="272987at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010490">
        <property type="entry name" value="COG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048369">
        <property type="entry name" value="COG6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048368">
        <property type="entry name" value="COG6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506">
        <property type="entry name" value="COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20653">
        <property type="entry name" value="COG6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06419">
        <property type="entry name" value="COG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01087">
        <property type="entry name" value="COG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric complex COG6 N-terminal" evidence="11">
        <location>
            <begin position="28"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved Oligomeric Golgi complex subunit 6 C-terminal" evidence="12">
        <location>
            <begin position="172"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR08447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="633" mass="73900" checksum="9F40A82EAD0C2EED" modified="2013-05-29" version="1">MDPLSKISQILSHSYSDTKVKELFKIISQTELKNDEISKKKFKIDNVSNIISINTKIIQEFEKIIIELKTFKDYISTIKNLTNEMEKEADIISLKSTHFLKQITTIYDRKILINTKQSLLKSFNNNFIIENEDLEILSSISKPVDERFFKILFKVKQIYLNCQKLLIAGYNKAGVEIMEKMDKYLDTGFEKLCYFIQQELKLAKYKSYEPKDDIKKALYMLSEKHDLFKKCLKTISKERQKFLPENSQFELIHNIPLTSIHQIKIQTYDLLQYTSDMLSWIHQTVVNEKDFFEILFGIHIDSESIKIMNDLPNFCSLSEYKDINKVVFEIIDNNILNSCEIFKIETESIIQDIENIVTIYRIANLIQFYHFTLQKIMPNDSCLLNILRNTEKSVMNAFSKNIQKKLHSIKKSNLFPSPQLEAPSFLINTISELKILHKSIEATHNSSESLENCVKTILKIILDPYCDLCCSISDKLDEPHKSIFLINCWKTCEENISQISPGNSKMQEFKDDINNLFKNLESNQLDYFFNASGLNNLINILESKEEKNLERSLDTVLVETSKNFQNFLPFAITNALDRIKYLEISNATRITNKAAEMFIEKISDLINILPQITDNYQTYFHWTPNEIKLLLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NML0</accession>
    <name>M7NML0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01673</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873635.1">
        <property type="nucleotide sequence ID" value="XM_007875444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NML0"/>
    <dbReference type="STRING" id="1069680.M7NML0"/>
    <dbReference type="GeneID" id="19895367"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01673"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016304_6_1_1"/>
    <dbReference type="OMA" id="VRIFKMQ"/>
    <dbReference type="OrthoDB" id="446113at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12611">
        <property type="entry name" value="RRM1_NGR1_NAM8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12613">
        <property type="entry name" value="RRM2_NGR1_NAM8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12346">
        <property type="entry name" value="RRM3_NGR1_NAM8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000065">
        <property type="entry name" value="mRNA binding post-transcriptional regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000222">
        <property type="entry name" value="mRNA binding post-transcriptional regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000227">
        <property type="entry name" value="mRNA binding post-transcriptional regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF10">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="66"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="159"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="275"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="344"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="394"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="452" mass="49609" checksum="F565C44E7456B845" modified="2013-05-29" version="1">MSFNYDYGKGNTPSSSVSTAQSQNNQIVPPTNTSSPTFQTSNAVSQNINNGKISTSQSPLQGENKTALWMGELEPWVDEAFIRQVWFNLGEQVNVKMIRDKFSGSNAGYCFVDFSSTAAASKALSLNGTIIPGTTRLFKLNWASGGGLTDRKDDREPEFSIFVGDLGPEVNEYLLVSLFQSRYPSCKSAKIMTDLVSGMSRGYGFVRFSDEMDQRRALTEMQGVYCGNRPIRISTATPKNKPGMNHINMMHMGMPPLGYYGAPQPMNQFTDPNNTTVFVGGLSSYVTEDELRSFFQGFGEITYVKIPPGKGCGFVQFVQRHAAEMAINQMQGYPIGSSRVRLSWGRSQNNSGPIGTPYRPNPPPPVPYASLGLPPQHAYSSFAPINPNAAHMHPPQQQGQPLPAQPGQLSGSQNPMDPIPVTLLNELYSATRNARLDRLEADRNSFHGVYAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMX3</accession>
    <name>M7NMX3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01787</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873755.1">
        <property type="nucleotide sequence ID" value="XM_007875564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMX3"/>
    <dbReference type="STRING" id="1069680.M7NMX3"/>
    <dbReference type="GeneID" id="19895481"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01787"/>
    <dbReference type="eggNOG" id="KOG0927">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_6_1"/>
    <dbReference type="OMA" id="YLDQHTK"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000011">
        <property type="entry name" value="Putative ABC transporter ATP-binding component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF131">
        <property type="entry name" value="RIBOSOME BIOGENESIS ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="242"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="560"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="510"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="788" mass="90358" checksum="EBA76C3FCD1C4FE3" modified="2013-05-29" version="1">MVKNKEKSQSQQKTKHLPLKKANVVVDNSKTKDNAAHVCHKAKKINQKDKKIYNFISDEDDHYNIDYKSEENIENYIEEWKIEKKNKESKKNMFNFLNEGFKENDVNNEENISDRTQEANHWMDPRSESVLKGLENLSTKNLDEEEGVSEAKLLKKDIKNQELNEKKKTRKERKMEYKKKIIETKALEKSKNGENILNEDKDQITTIYSHASGSLIVSENTHISKAIAVTGNLVSPLNSKNLQVDKVTIQAYGKLLIKESELNLINGRRYGLIAPNGSGKSTLMHAIASNLIPRPPALDVYLLDKEYTPTKMTCIEALLDINEYEKRCLEEELISLLDDPDKNSVRISSIGQRIGELEIGGSDHKARHILEGLGFSEEMIQQKTCDLSGGWRMRISLARILFVKPTLILLDEPTNHLDFEAIAWLEDYLVHELNGHTLLMTSHSQDTLNEVCTDIIHLYNNHLYYYSGNYDTFKKIRKEKDIQIMKKTKIKENKMEILQKKMNMTGNKQREQAKSRIATMEKKMEKDKQKNKVLEEEIVKEKKLIIRFEECSGGIPSPAIKFRDVSFGFPNKRLLFKNLNFGVDLNSKIALVGPNGAGKTTLIKLFMGSLQPISGDITRHHHLRIAQFHQHMNDQLNLDISAVQWLHEISPERSEGSMRGFLGSYGLTGKSQVIPMKQLSDGQRRRVLFAFLGLKNPHIIMFDEPTNALDINTIDALSDAINNFNGGAIIISHDFVLINRVATEIWVIENGEVKVWDGNIKEYKENLKKKFQKKREKEAELAVLGKTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN74</accession>
    <name>M7NN74_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED18</name>
        <name evidence="9" type="ORF">PNEG_01414</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873351.1">
        <property type="nucleotide sequence ID" value="XM_007875160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN74"/>
    <dbReference type="STRING" id="1069680.M7NN74"/>
    <dbReference type="GeneID" id="19895111"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01414"/>
    <dbReference type="eggNOG" id="ENOG502S7EN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1200630_0_0_1"/>
    <dbReference type="OMA" id="PVHQHHE"/>
    <dbReference type="OrthoDB" id="5348092at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019095">
        <property type="entry name" value="Mediator_Med18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13321:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13321">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION, SUBUNIT 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09637">
        <property type="entry name" value="Med18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="231" mass="26491" checksum="5B2E13FFA51AAF48" modified="2013-05-29" version="1">MQEISLFSGISCHRREKVIQLLERLTGRKQHEFKEWHLVYAPPASLESDSALLVRPDLYLRLSTSLTNSCLVDNNSNNDFLLAPNDTSNILMQFSSYDWKISLVDAPDMGVKRPVTSRLYLQSRVLSGNVFAFLEELDYVFHFEYVMQGVQFIYGNCILILFQTLRPLEKHLLEDLVHVDISGGWILQASVYIEDASDQALMTQATDELAQIRKILNGICHLEPVTDNRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN83</accession>
    <name>M7NN83_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Biogenesis of lysosome-related organelles complex 1 subunit KXD1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873362.1">
        <property type="nucleotide sequence ID" value="XM_007875171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN83"/>
    <dbReference type="GeneID" id="19895120"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01423"/>
    <dbReference type="HOGENOM" id="CLU_1670116_0_0_1"/>
    <dbReference type="OrthoDB" id="5342763at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="18870" checksum="A3598751FFF82777" modified="2013-05-29" version="1">MENSPIDITSKDDFDEKPLSIEILDLLEHLKERIQNLTEKQTYLNEYLSKEKDNFNKISEYKDIILNIQAIPKYISKTKYLKHKVKFFGEKIDYLSEFSRQIYNKRHDLSEQWKTIKKIEQKKDITRLLAQKSNKDNSPPVVTLKRDVSKVKDAYIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNG7</accession>
    <name>M7NNG7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BOD1/SHG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874886.1">
        <property type="nucleotide sequence ID" value="XM_007876695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNG7"/>
    <dbReference type="STRING" id="1069680.M7NNG7"/>
    <dbReference type="GeneID" id="19896535"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02848"/>
    <dbReference type="eggNOG" id="ENOG502S313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1971787_0_0_1"/>
    <dbReference type="OrthoDB" id="5579731at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055264">
        <property type="entry name" value="BOD1/SHG1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05205">
        <property type="entry name" value="COMPASS-Shg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BOD1/SHG1" evidence="1">
        <location>
            <begin position="9"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="121" mass="14247" checksum="AA9C85778A0575F4" modified="2013-05-29" version="1">MDEEITITELVHKFKLNGKFDSLRKEILTIYKNSNTGLQLKSKLEEIIKKEIDNNHTLFTQDRGKTVIMISNIIDKSEVYNHARELMNDTIFMSKEFRTRVNIIMQEIKNDLEKITEKGNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNK5</accession>
    <name>M7NNK5_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873468.1">
        <property type="nucleotide sequence ID" value="XM_007875277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNK5"/>
    <dbReference type="STRING" id="1069680.M7NNK5"/>
    <dbReference type="GeneID" id="19895219"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01524"/>
    <dbReference type="eggNOG" id="ENOG502R7SZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_295273_0_0_1"/>
    <dbReference type="OrthoDB" id="3647690at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070823">
        <property type="term" value="C:HDA1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038609">
        <property type="entry name" value="HDA1_su2/3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021006">
        <property type="entry name" value="Hda2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11496">
        <property type="entry name" value="HDA2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="761"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="898"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1025" mass="119363" checksum="CF48C9D2BCAB970E" modified="2013-05-29" version="1">MKNIYTNKYKKEETNDGNFEYESNVFNEKKYKNNRKNTDNICEIDKLKEDKLERIDSENGDLLFSSVANSQNNTYFEPYESLEYTQELPQMIHSDTPVYEKSTNAKILGDMEKTYHASPTKLDNILPSIDLNTELKYDPLETPMTDIAMGRVFNFSEFSKKPLNIENDQDILLEDTASSIYHMANDNNIKTSSSRMDMFSKPGSIDNISNVSYDKYKKEVDNNDEKTAALKEKNVSKTQKRLKKNHCDNISKNYHQQLESPSPSEKVSTWLSNNESIQLKILNDSHVQTYTPIANIQENRLNNIEYNYLDSCISIESESLFSVEKDNISMKSKISDEGISEKYDNNTSTVSAFDDFIVSLRSVQNKPHIYFFGIEMNNTQRNMYLQLILQYNDLLQEFCSTLNPDKTLIKKAQRFINILTMLTIHPYLIFKDKFENEFLEKIELENLVHSSPKFIFLATFLEKSKNLELVIGISSDNEMLLDLIEILIKKLNILYLKTNQYSENINIRKNIKVLLIAYGKGKGENLEIYSDIVICIYTSTHILSIRNFNYSSDDKIKNHIIPITINSVEHIQLSVMKDIPQILYFQNVAKITILLRKFAGILPSNQFFSNESPQLVYNWIKGNYKDKWMLPRVSDLRELAITLTHKDSRLISEEQLNYLLELKEKIYQHDNYLFKVHQEIHDTSNITSKSDSFDSSDKKILEDLSSQFEISQLQSNVCDFSANNRLNCLTLSSEAIQRSCLDNVKISSNTKTEKDLLYIEINDLKNNLFTTQSLLKNTENELLSFKISTDRLQKRYEEMQEQYRNLSLEFKNIVNIKDELQKSLNNLQENFINVQKNLASSSEMEKLKRKSLSSENQEKVSTNTSFVLEKEYLSEENSRLKKIIENKTFDFEFLRSQYQEASSSALNLANEVKQLEAENALLKNKAEGEALRLKEIMIQLLEKKLDERIEELEIQNSLYLKQLKQKMNDESTKHSYPYEPYQLINMSQNTKMIPRKCLIRNINIQSSEDLNGRSTSEIAININEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNQ0</accession>
    <name>M7NNQ0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_02920</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874962.1">
        <property type="nucleotide sequence ID" value="XM_007876771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNQ0"/>
    <dbReference type="STRING" id="1069680.M7NNQ0"/>
    <dbReference type="MEROPS" id="C12.002"/>
    <dbReference type="GeneID" id="19896607"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02920"/>
    <dbReference type="eggNOG" id="KOG1415">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054406_0_2_1"/>
    <dbReference type="OMA" id="IDLHYVC"/>
    <dbReference type="OrthoDB" id="427186at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="206" mass="23460" checksum="F4AF44F3472C1114" modified="2013-05-29" version="1">MLEFIPRPVYALLFVFPVKESDKNCNSIKTKEILIKNQKNVIWFKQTVRNSCGAIALLHATTNGGAKNFILPNTLLANLLKKIEYLSSSSLSNMFEFSQLKTIHESKKKNYFILYFLKIEFASQGETTPPGALEDISLHYICFVKSSVDGHLYELDGRNPLGPIDHGLLNDNDILGNQTIQIIKNYINKREKDIQFSLCALAYKFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPE9</accession>
    <name>M7NPE9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="10">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_02746</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the phage and mitochondrial RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="10"/>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874777.1">
        <property type="nucleotide sequence ID" value="XM_007876586.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPE9"/>
    <dbReference type="STRING" id="1069680.M7NPE9"/>
    <dbReference type="GeneID" id="19896437"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02746"/>
    <dbReference type="eggNOG" id="KOG1038">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003364_1_0_1"/>
    <dbReference type="OMA" id="KWFEVDM"/>
    <dbReference type="OrthoDB" id="276422at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034245">
        <property type="term" value="C:mitochondrial DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001018">
        <property type="term" value="F:mitochondrial promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006391">
        <property type="term" value="P:transcription initiation at mitochondrial promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1320.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000041">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.280:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1320.10">
        <property type="entry name" value="DNA-directed RNA polymerase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024075">
        <property type="entry name" value="DNA-dir_RNA_pol_helix_hairp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046950">
        <property type="entry name" value="DNA-dir_Rpol_C_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002092">
        <property type="entry name" value="DNA-dir_Rpol_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037159">
        <property type="entry name" value="RNA_POL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029262">
        <property type="entry name" value="RPOL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00940">
        <property type="entry name" value="RNA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14700">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01311">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00900">
        <property type="entry name" value="RNA_POL_PHAGE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00489">
        <property type="entry name" value="RNA_POL_PHAGE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase N-terminal" evidence="12">
        <location>
            <begin position="316"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR08971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1259" mass="144772" checksum="39BB6B812C54195B" modified="2013-05-29" version="1">MINIFNTLPTCTKIFKRMRYYFYLTNIIKKRNVKFNFFQHIHNQYNCFQESEPSKNINISLEKKSPIIILPIPKQSTQFHKGGLPRGITFYDNNELLAVFDACVSTGDLNRGYILMNRLSHEAEPSFIIQIHNRYLQALVDKIKKTGDFESINKCFHDLEKKYNIIGNETTFALMLKAALYIKDPEESKITINGFNKLWHLKKKENIGKIFNESSVLDHQEILNIFKIMNINFSELKQEYRHILKKVVDVDEKGSTNTYLFHPLENVPELLSTCVSGPGLQLLKKTLRPLTDPNTEINYDIKDLSGEFHSTSFNMARQRLLENNALDTALERWKWDHEQLVQRGGLSFSKTLNPLLFEWHSLMIPLIKEEIERCKNAINNLSNKRNSNNTETDRLSYGPFIQLLSPEKLGTITILEILRLHSTGGIAQGMRTARAILSVGKSIEKEYASELLKKNKNILGKDINLSQIFGNPRQFQSALYKTQNNVNFEIYPKWPVTVKAKIGSILVSILMHVAKIDVITETENENISQKTPAFYHTYQYQKGRKLGVIKLNDQLMKQLGSQPLRGNIHPRLLPMLVEPKPWISWDSGGYYLSKSIVMRSRDSPEQINYLKTASERNNLKSIFEGLDVLGSTAWAINRPVFDVVSEVWNSGQEFAEIPPVNSDITFPPQPTSKDPGERISWQVLCKQIARDAQNKQSIRCDINYKLEIARAFLHEKMYFPHNLDFRGRAYPIPPHFNHLGNDLCRGLLTFHEAKEIGESGLRWLKIHLANVCGFDKESFIEREAFTTENLKNIFDSADNPLKGSRWWLTFDDPWQTLAACFELTAALRSPDPYKFKSRLPVHQDGTCNGLQHYAALGGDILGARQVNLEPSNRPYDVYTKVAELVNEQLQKDAKEGNHLAVLLQGKITRKIVKQTVMTNVYGVTYVGARNQILNQLKNINDLPREMLFNLASYLAKTVFFSLKSMFTGAHKIQEWLNEAAKRISKSINTSLSDDINLMTSVIWTSPLNLPIVQPYRKLSRKQIKTNLQSIFITDPNNINPVDTRKQQTAFPPNFIHSLDATHMLMSAVSCKNAGLTFASVHDSYWTHAADIDNMNVILRETFVKLHKENIMENLLNEFRERYKGYKTLISISKSSKEGKKILSSKKKKLQETNKISLINNDNKSETYENLSTKDICITNDEKNTVNLSDFTSKKTDYLNLENSNSILEEKNESTIETNTKSEKKRKDLIHVWIDLEFPPLPKKGNFDVRNLRNSKYFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPH3</accession>
    <name>M7NPH3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_03610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 33 different proteins. The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and at least 46 different proteins. eS26 interacts with eS1 forming part of the mRNA exit tunnel. eS26 interacts with TSR2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eS26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874626.1">
        <property type="nucleotide sequence ID" value="XM_007876435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPH3"/>
    <dbReference type="STRING" id="1069680.M7NPH3"/>
    <dbReference type="GeneID" id="19897297"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03610"/>
    <dbReference type="eggNOG" id="KOG1768">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129451_1_0_1"/>
    <dbReference type="OMA" id="KCYCVSC"/>
    <dbReference type="OrthoDB" id="10262653at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1740.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.20">
        <property type="entry name" value="Ribosomal protein S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000892">
        <property type="entry name" value="Ribosomal_eS26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047864">
        <property type="entry name" value="Ribosomal_eS26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038551">
        <property type="entry name" value="Ribosomal_eS26_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01283">
        <property type="entry name" value="Ribosomal_S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00733">
        <property type="entry name" value="RIBOSOMAL_S26E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00061939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="123" mass="14117" checksum="1CC61E056038CED6" modified="2013-05-29" version="1">MTFKRRNNGRNKHGRGHTDSIRCSNCARCVPKDKAIKRFTVRNMVESAAIRDISDASVYQEYALPKLYIKLHYCVSCAIHSHIVRVRSREGRRIRVVPLRAHYNKDGRKINPTSAAKALISQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPJ9</accession>
    <name>M7NPJ9_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02799</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874832.1">
        <property type="nucleotide sequence ID" value="XM_007876641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPJ9"/>
    <dbReference type="STRING" id="1069680.M7NPJ9"/>
    <dbReference type="GeneID" id="19896488"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02799"/>
    <dbReference type="eggNOG" id="KOG1126">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008850_0_1_1"/>
    <dbReference type="OMA" id="WHSPQAW"/>
    <dbReference type="OrthoDB" id="329563at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051728">
        <property type="term" value="P:cell cycle switching, mitotic to meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000018">
        <property type="entry name" value="Cell division cycle protein 27 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="443"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="511"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="545"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="579"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="613"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="681"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="300"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="747" mass="84741" checksum="5B06B7383C3DF0FB" modified="2013-05-29" version="1">MSLKAYIVQQFREIIWYSLDNGLLSNATFIAERLYVYDTSNADAKHLFSLCLLRSGRYLTVLYMTEGVKHVGCAYIYALACLQLGKCKQGIAALEAVSSQWTKSNYMYQHDDLYRSHLPDAAAIFCLLGHLSKKGGMMKKATDYYICSVKLNPFLWEAFDGLCALGCNLHVKNIFKATAGMQAARLKAQNIPVQTNILKNMDSYMSQNIDTEAQSMNHTVQTPDIFNSQKNHTPPFASHCQQSSFLDRLEMVETPGSPTQQVDSSEIAHGFLDHSISTSSSFISPPNFLDTKIRLNQTKANPTIRSNIDKDLPKSSTPIDIPQRRSQRHLPNASKIASKLVSTTSSIRDSRKNKSQNSRSKQEEIPQSSIIQIPGSNQSCFQYGQKPNGQTVMSLVERIEAETCLLDLCKSIADGCHALAKYDGAKAIECFKSLQPASQRNSVFVLSKIGRAYFEMVNYDEAEKYFYRLRKADPTRVEDMEIYSTVLWHLRKEVELSFLAHEILDLDRLAPQSWCIIANCFSLQREHDHALKCIRRAIQLNPNFAYAYTLEGHEYVANEEYERAQTSFRNAMRVDMRHYNAWYGIGMVFLRVGKNDLAMYHFRKAAEINPTNAVLLCCIGMIVERNKDFPEALQLYKKASELAPTSALARFKKAKVLVCLRQYHLALKELLFLKDLAPDEANVHFLLGKLYKQLGDKPSAMRHLTVALNLDNRASHLIKEAIESIDEPEENLLGETGEVYKNLDREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPW4</accession>
    <name>M7NPW4_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_02493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874504.1">
        <property type="nucleotide sequence ID" value="XM_007876313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPW4"/>
    <dbReference type="STRING" id="1069680.M7NPW4"/>
    <dbReference type="GeneID" id="19896186"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02493"/>
    <dbReference type="HOGENOM" id="CLU_103450_0_0_1"/>
    <dbReference type="OrthoDB" id="14339at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332:SF1">
        <property type="entry name" value="ELMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR09151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="234" mass="27546" checksum="D8AAC33950B0A721" modified="2013-05-29" version="1">MPLSLHVLIREVAGIKEKRFRLIQHITQIHDGDIHWLNTIFLEKNQIDIYFNVKPACKKTQSYHMLGYLLSSLVPPSTSQTFEDYLKNYLTILTTWETTTRDFGTWTPRMKAFFGSRGSRKSNFNIENSYFDEEESVTKSLTYPHLPFMPSYTQTVLVLCDLLRETYTVITNIILNTRYNRFIEIFYRIDNKIKKILETMAKDIEAYAREMIKKELNSLLQLSDTEEDSNKASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQC0</accession>
    <name>M7NQC0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major surface glycoprotein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_03600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09276.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874625.2">
        <property type="nucleotide sequence ID" value="XM_007876434.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQC0"/>
    <dbReference type="STRING" id="1069680.M7NQC0"/>
    <dbReference type="GeneID" id="19897287"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03600"/>
    <dbReference type="eggNOG" id="KOG3544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010455_0_0_1"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021041">
        <property type="entry name" value="Maj_surf_glycoprot_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003330">
        <property type="entry name" value="MSG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02349">
        <property type="entry name" value="MSG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12373">
        <property type="entry name" value="Msg2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Major surface glycoprotein 2 C-terminal" evidence="3">
        <location>
            <begin position="978"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="812"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1065"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1143"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="116"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="812"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="853"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="923"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="933"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1065"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1151"/>
            <end position="1171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR09276.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1194" mass="133685" checksum="39D14D599C0B6191" modified="2016-03-16" version="2">MYAYHKKIKMYGYFERIISRFRFDSPSHMLLRDKRWVEEVAQKEAAMAQPVKRQAAGQAAGNDEIKEEQVLGLIVKKEYNDDAKCKKKLEEYCAELKKIDGELKNVDVKVKGLCENGKQEEKCKNLKNKVKKELDDFKTEVEEALKNLTDEKCKKCEEKCVLLEEADPTNLEEKCVKLRDRCYGQRRREVTKEILLRALKGKVNDTNECKKKMKEICQGLSEYSDELVFSCFNSDKTCEYLGKNHGDNCKPLEKELEDKELVEKCQEYLEKCYFYGSSCSNSKCKESKEKCKGKGIVYEGPKLDFSPVGEKPRFPEKIEVENLYKKEEAKGIIVGKPKYKTLQDLILLLIKGRTEKDNKEKCKEALKGCEFFKHLDYELEELCEDKDKDKENKCKELVEVEDKCTNFKLELYLKGLSTEFEKDKESEYFSWEQVSKLVSREDCRKFESECFHLESVCTNKIEKACENVRVACYKKGQDRMLNRYFQEGLKGLIGNLGLADENLKECQKSVVGNYTKLKKDRRYFAKCHRPTELCYELLDDVILQSEELEVVLNLRRDFPRKEDCVELKKKCEDLESDSYLNHEKCDTLNRRCEYLKVTEELRKRLLKRGDDALRTQGNCTAVLKKECEELSRRGKDEFSVSCALREETCSFMVEQTENECLFLENNMDNGKILNKIENGNETLVEELCTLFDPYCHQYIENCPDRLKKEKNSNKNGVCLQLEEKCKPFFEKLKLENELTHELKGSLSDETECKKALGKHCTEQKDPANKKFNSFCNTDKNKDVEEKVCKKLVEKVKRKCPTLEDKLDKEKDELKKKKDEYEKVKQESEKFTKEAKLVLSKPEQDGQDGNAPKPGGPPVQPPVPGGTPGGVPVPAPTLAPPAPVPGGTPGSVPVPAPTLAPGAPGAPGAPGAPGTPGAPGAPGTPGAPAGPAAPSTPPAPAGPAGPAGPAGPSGGTPGAPAGPPAPGGSTPSGTTNTSNVILVRRTFVSGEVSEPEKKAFVATARALELYLELKEKCKGLKGDCEFRKDCPKCETVCKEIDELCEGIEGLKVTPHHTVTSTATQTTTTTATTTTTTTTTTTTTTTTTTTATTTESVDGGKVTEECTLVQTTDTWVTSTSLHTSTLTSTSTVTSTVTLTSMRKCKPTRCTSDSSKETETQKEEEKEEEVKPNEGMKIRVPEMIKIMLLGVIVMGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQF3</accession>
    <name>M7NQF3_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-dependent chaperone ClpB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02274</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Homohexamer, forming a ring with a central pore.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09316.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874265.2">
        <property type="nucleotide sequence ID" value="XM_007876074.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQF3"/>
    <dbReference type="STRING" id="1069680.M7NQF3"/>
    <dbReference type="GeneID" id="19895967"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02274"/>
    <dbReference type="HOGENOM" id="CLU_235089_0_0_1"/>
    <dbReference type="OMA" id="ERMKAVM"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140602">
        <property type="term" value="C:nucleolar peripheral inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140453">
        <property type="term" value="C:protein aggregate center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="entry name" value="Clp, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF18">
        <property type="entry name" value="HEAT SHOCK PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="Double Clp-N motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="10">
        <location>
            <begin position="2"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="406"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09316.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="901" mass="101634" checksum="D495004E465A9132" modified="2016-03-16" version="2">MMNYQFTDKTEKTIAESYSLAQSSGHIQIFPVHIASVLLKEESPQLIRLVVEKSGGDLVKFEREVLRLFVRIPTQENPPENVMLSPQCMKVLKTAHELQKLQRDTYMSQDHLILALAEDPSIKKALEEAGVTFQLLDQAIRKIRGNRHIESKSAELGYDSLSKYTVDLTEQARNGALDPVIGREDEIRRTVRVLSRRTKNNPVLIGDPGVGKSSVVEGLAQRIINADVPSNLFACRLLSLDVGALVAGSKFRGEFEERIKSVLKEIEDSQETIILFVDEIHLLMGAGNTGEGGMDAANLLKPMLARGKLHCIGATTLGEYRKYIEKDAAFERRFQQILVKEPSVPECISILRGLKEKYEVHHGVTILDSSLVSAATLASRYLTNRRLPDSAIDLVDEAAAAVRVARDSAPEELDSLERQLRQLQVEIHALEREKDNLSKERLAKARLEMENVEEKLMPLRERYQIEKQRANDIQRAKKKLDELKAKAIDAERRMDLQTAADLTYYAIPDLQKRIEDLEILKAKADAEIIEKSNCPKLLLTDVVTTDQINEIVSRWTGIPVTRLTLSEKEKLLKMEKSLTQFVVGQKEAVKAVANAIRLNRSGLSNPNQPIASFLFCGPSGTGKTLLTKQLAEFLFDDKKAMIRIDMSEYTEKHSVSRLIGAPPGYVGYDQGGQLTEQLKRRPFSIILFDEIEKAAQEVLTVLLQVLDDGRLTSGQSQTIDAKNAIIIMTSNLGAEYLTNAAVTSDGKIDDITKAMVMDSIRKFFRPEFLGRTTVVMFNRLTKKNMQKIVIKRIEEIQKRLEDNNKKIKIDVDEAVITYLSEAGYSPSYGARPLNRLIQNEILNKLSVFMLRGQIRENETVNIFLHEKKIYIQPNHESTSDTLDESMDDEVMSEDIDTEEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQH5</accession>
    <name>M7NQH5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00576</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR10973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872471.1">
        <property type="nucleotide sequence ID" value="XM_007874280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQH5"/>
    <dbReference type="STRING" id="1069680.M7NQH5"/>
    <dbReference type="GeneID" id="19894274"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00576"/>
    <dbReference type="eggNOG" id="KOG0015">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063931_1_0_1"/>
    <dbReference type="OrthoDB" id="2284405at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00266">
        <property type="entry name" value="MADS_SRF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000002">
        <property type="entry name" value="Serum response factor b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033897">
        <property type="entry name" value="SRF-like_MADS-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="36"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="214" mass="23921" checksum="2B0C47446F0036E1" modified="2013-05-29" version="1">MTQKRGVEDGELLGGSVEEEGKRARTEEDDEDKVNRERRKIEIKFIEDKSRRHITFSKRKAGIMKKAYELSVLTGTQVLLLVVSETGLVYTFTTPKLQPLVTKAEGKNLIQACLNAQDSGTGIQDEAEPNIINGPTAIGANLQSYPPPPPSMRALYFNPDQAAVYQQYMQQPPYMQPGRMLAQPPPPQHHLPHLVPMGGHLPHHMGDVHIRVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRL6</accession>
    <name>M7NRL6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TFIIS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01936</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IWS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873912.1">
        <property type="nucleotide sequence ID" value="XM_007875721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRL6"/>
    <dbReference type="STRING" id="1069680.M7NRL6"/>
    <dbReference type="GeneID" id="19895630"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01936"/>
    <dbReference type="eggNOG" id="KOG1793">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045275_1_0_1"/>
    <dbReference type="OMA" id="MPAYNIQ"/>
    <dbReference type="OrthoDB" id="21124at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.10:FF:000003">
        <property type="entry name" value="Putative Transcription factor IWS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
        <property type="entry name" value="RNAPII_TF_IWS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010:SF1">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="8">
        <location>
            <begin position="195"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="372" mass="43214" checksum="DFB59712C92EC837" modified="2013-05-29" version="1">MNKKEERIRNPTSSKKMDEFDLDTDEELSELDEEQFKDLKDSQVEKADLTEYTMHNLPKFKRKGLLQEGSVKPKKSKLIRKRRRTHETLLEENKDELSSKMDPDKLARWELDQALNEAIMSSRRKKRKGEEDLEGMADDEIIALREKMRQAAIEDVQANAEKKPATQKLKMLSEVEDALRKTSFTDSILDNNLLEVVRIWLEPLPDKSLPALNIQKVLFSALSRLPIQTEHLRESGVGKVVLFYKQSKKPDPLIKKQADQLISEWSRPIIKRSSNYRDRSISTVLYNPNTAMYNDQRISNSDIIDSKAYKKTIIPVPVNTSYEIAPKVHLKVNHNISKMRNDDHLRKLKQKMQKMKQPVKRNGISIEGRGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRN1</accession>
    <name>M7NRN1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-chaperonin molecular chaperone ATPase</fullName>
            <ecNumber evidence="1">3.6.4.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00426</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="1"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872304.1">
        <property type="nucleotide sequence ID" value="XM_007874113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRN1"/>
    <dbReference type="STRING" id="1069680.M7NRN1"/>
    <dbReference type="GeneID" id="19894124"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00426"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_0_1_1"/>
    <dbReference type="OMA" id="NIPPMQA"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000004">
        <property type="entry name" value="Heat shock protein SSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000005">
        <property type="entry name" value="Heat shock protein ssb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="612" mass="68184" checksum="7716725EC40BFD51" modified="2013-05-29" version="1">MEVYNGAIGIDLGTTYSCCAVWTDDSPNVEIIANDQGNRTTPSYVAFVENERLIGESAKNQAAINPQNTIFDVKRLIGRRYDDPDVRNDIKTWPFKVIDIDGSPQIEVEYLNEKRIFSPQEISAMVLGKMKEIAETKLNKKVEKAVITVPAYFSDSQRLSTKDAGAIAGLNVLRIINEPTAAAIAYGLDSKSEKEKNVLIFDLGGGTFDVSLLTIQGGVFSVRATAGDTHLGGEDFDNNLLEYFKAEFKRKTKLDLDDDPRALRRLRTACERAKRALSSVMQTTIEVDSLKDGHDFICNINRARFEDINSKIFYSTLEPVKRVLKDSKIEKSEIDDIVLVGGSTRIPRIQKLVSEYFDNKPLNKSINPDECVAYGAAVQAAILTNKANSEKTSDLLLLDVCPLSFGVAMEGNIFGVVVPRNTPIPTIKKRTFTTVKDSQTTVVFPVYQGERVNCLENEFLGEFELQDIPPLQKGQAELEAIFELDANGILKVTAKEKSTGKSAHIEISNSVGRLSSQQIQDMINNAKKFSEKDKEFSKRIELKQTLEAYISSIESTINDPSIAMKLKKTQKKNIENALADAISALEIEDYDTLKRTELDLKRITTKTFSLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSK0</accession>
    <name>M7NSK0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01508</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873447.1">
        <property type="nucleotide sequence ID" value="XM_007875256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSK0"/>
    <dbReference type="STRING" id="1069680.M7NSK0"/>
    <dbReference type="GeneID" id="19895203"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01508"/>
    <dbReference type="eggNOG" id="KOG3327">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049131_3_1_1"/>
    <dbReference type="OMA" id="YWHQFDA"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120136">
        <property type="term" value="F:dUMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01672">
        <property type="entry name" value="TMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000679">
        <property type="entry name" value="Thymidylate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF1">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="10">
        <location>
            <begin position="14"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR10237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="215" mass="24721" checksum="775FEB690782BAC3" modified="2013-05-29" version="1">MVDISRKRGAFILIEGPDHSGKTTQCELLAEEFCTKNVPVKIQKFPNRSTEIGKIIDLYLRGDLELEEHAIHLLFSANRWEISKKIRNDLENGITVIVDRYIYSGIAFSVAKGLNIEWCRSSDKGLPLPDGVIYLDICDKMASLRHNYGLERLETNTIQKKVRSIFKNMFEKNHNTGYPWYWVDASNSIIQVKINVWNAAQDIINNLSDDIKEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSR2</accession>
    <name>M7NSR2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Signal recognition particle subunit SRP72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_00205</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SRP72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872073.1">
        <property type="nucleotide sequence ID" value="XM_007873882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSR2"/>
    <dbReference type="STRING" id="1069680.M7NSR2"/>
    <dbReference type="GeneID" id="19893903"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00205"/>
    <dbReference type="eggNOG" id="KOG2376">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013808_1_0_1"/>
    <dbReference type="OMA" id="NDMKVLA"/>
    <dbReference type="OrthoDB" id="5421607at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013699">
        <property type="entry name" value="Signal_recog_part_SRP72_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031545">
        <property type="entry name" value="SRP72_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094:SF9">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08492">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17004">
        <property type="entry name" value="SRP_TPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038922">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="Signal recognition particle SRP72 subunit RNA-binding" evidence="11">
        <location>
            <begin position="538"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="533"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="541"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="558"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="573"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR11778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="610" mass="70588" checksum="7D03E32677C86071" modified="2013-05-29" version="1">MELQDSGHLLRKTDNLKDLFMKLSIAISNNKHEEVIELSDKIKGFSISDIKSTKSKIIALIKLDRYSEALFLIRSELSAEKALLEMIYCLFMLKKYEEAMDWAKKSNKREIKHIKAQIAYQKDQMIDASEIYKELQQDPYRIENEEFDLSINLLATQVTWPSIEISNHPAIYQSLDYRFNIGCHLIYRKEYMKAKELFELSKEQCLSTTSQEEMKSRLHPILVQLAYIYSSIGQESDAISIYEDLINKSHVDQIIKLICINNYYTIKSDANPYLILYSLNTILSNAKLSKLTNTQNKIIHKNMAILNILCKKYSACHNIVKKLQNTYPDDETIILILVSSIISRFTGNRAYSELIKLHEKNSSNVTLSLAIIQFMISSKDNYNTQKIIEKLLDSLKDNKSIRFKPELVRLLVEIYEKRGRKDLSRQELYAASEYWRNTGSNDPNLIELLCESGKLKLKSMIKKKESNLSPVDDFTYILKLSPNNQKALAGLVIYYLDTDINEASKYANKLPALDVLTQGIDVDHLEKSGIVNHSLKEKKNNHSKSLLKQKRKKSKLPKNYDPDKQPDPERWIPKKQRSYYKSSKGKKRQSNKTQGELVVENNFTTNTGNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSS3</accession>
    <name>M7NSS3_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NEDD8 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873380.1">
        <property type="nucleotide sequence ID" value="XM_007875189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSS3"/>
    <dbReference type="STRING" id="1069680.M7NSS3"/>
    <dbReference type="GeneID" id="19895137"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01440"/>
    <dbReference type="eggNOG" id="KOG0005">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010412_6_4_1"/>
    <dbReference type="OMA" id="YAGKQMA"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01806">
        <property type="entry name" value="Ubl_NEDD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000023">
        <property type="entry name" value="NEDD8 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038738">
        <property type="entry name" value="Nedd8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="78" mass="8797" checksum="ADA123A443D802C6" modified="2013-05-29" version="1">MLIKVKTLTGKEIELDIDPSDKVIRIKERMEEKEGIPPIQQRLIFGGKQMSDERTASEYNLEGGSVLHLVLALRGGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTC1</accession>
    <name>M7NTC1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Delta(14)-sterol reductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">C-14 sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Sterol C14-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PNEG_01240</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17813"/>
            <dbReference type="ChEBI" id="CHEBI:18364"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.70"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:18563"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="15">Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873161.1">
        <property type="nucleotide sequence ID" value="XM_007874970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTC1"/>
    <dbReference type="STRING" id="1069680.M7NTC1"/>
    <dbReference type="GeneID" id="19894937"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01240"/>
    <dbReference type="eggNOG" id="KOG1435">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015631_0_3_1"/>
    <dbReference type="OMA" id="EWCELRP"/>
    <dbReference type="OrthoDB" id="10262235at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000009">
        <property type="entry name" value="C-14 sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="8 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="9 16" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="366"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00060638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMR10532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="426" mass="50094" checksum="298DEC10608D90CF" modified="2013-05-29" version="1">MKLQIKDLSVKKRSYEFGGPLGIIAIIFGTLLTVFELYLLCNENGCNVSVKYVRNSFFLLGDLWDPIAFLIYFLWWILLIVCWIFIPGDIKKGNYLSHGVCLSYKMNGFRSLVFVLSCCIIGFYLKGMYFLEFIWDHYPGLITSSLIFSVLFSCYTYGCSFFPGRYLSENGNTGNWIYDFYMGRELNPRIGSFDIKEFVELRPGIILWVVFNLSFAVHQYIILKGRITASMFLVCLFQIWYAIDSLWNEELVLTTMDIVTEGFGFMLCFGSITWVPFTYSLQARYLAFHPVYLNKFAILGISMLQCLGFWIFRSANLQKNTFRKNPTAPSIQHLTYITTERGTKLITSGWWGKSRHINYFGDWLMAWAWCLPTGFENPITYFYVVFFAILLIHRERRDNYNCHLKYGKDWERYCHQVPYRIIPYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTJ6</accession>
    <name>M7NTJ6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pumilio homology domain family member 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01310</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PUF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873236.1">
        <property type="nucleotide sequence ID" value="XM_007875045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTJ6"/>
    <dbReference type="STRING" id="1069680.M7NTJ6"/>
    <dbReference type="GeneID" id="19895007"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01310"/>
    <dbReference type="eggNOG" id="KOG1488">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_382672_0_0_1"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000004">
        <property type="entry name" value="Pumilio homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="8">
        <location>
            <begin position="367"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="387"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="423"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="459"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="495"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="531"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="600"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="637"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00081811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="723" mass="83916" checksum="791D92085A5DC40F" modified="2013-05-29" version="1">MGSTNLSQPYKKDPKDSWCRNTSNMIHTGDNNIYGNRFWPDTTMILKDSLLKSPAHSQANEGLNTFPSFTTLQQTRYLQAASAQAAAMTHNMKLSGKEIYVPDLSVVEKTQGSHGLRQVFSGLNDGYSGEYGDMFEEKQDTIAKEEILDKLSKLRVNYHKHDEIQKNSQVSYLHQAKDNEINYNYQKNNLFNYYTLMQNMRHETLNSKDCDRIYSMDQKKNSMKSLIHPYMGYTNNLRNFFKESSLNQNGSYKYNGISKKQMYSYYSVKDNDFPKNTVNMQSTVPTKHPLKDTTPLVTYSESETVQKDYSQGGETQPTGYSEDMFYYPQQYYDDTLHVLQQTYVRPISSTLNFSTQIRRENDRYQSLRSSLLEEFRNNKNKKYELKDIFGHIVEFSGDQHGSRFIQQALEEANSEDKEVVFQEIYPNSLQLMTDVFGNYIIQKFIEHGSQTQKTLLLEQMKGHILNLSLQTYGCRVVQKALEYIEIDQQINLVKELDGNVLRCIKNQNGNHVIQKIIEKVPMKHMQFIINTFQGQIYTLATHPYGCRVVQRMLGYCSQARDLLNELHLYSRSLIRDQYGNYCIQHIIEKGEPEDRSKVISVVKENILKFSKHKFASNVVEKCITYGTDEEKRLLIDKIMENDEDGFPRLLPMMKDQYANYVIKKALDVASGDQLNKLIAEIKPHLQFLKKNVHGKALSLNIERLITLSNNQSNQNNETLVTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTV7</accession>
    <name>M7NTV7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP-1 complex subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_01252</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit APL4 and beta-type subunit APL2), a medium adaptin (mu-type subunit APM1) and a small adaptin (sigma-type subunit APS1). AP-1 interacts with clathrin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873175.1">
        <property type="nucleotide sequence ID" value="XM_007874984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTV7"/>
    <dbReference type="STRING" id="1069680.M7NTV7"/>
    <dbReference type="GeneID" id="19894949"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01252"/>
    <dbReference type="eggNOG" id="KOG1062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003824_0_0_1"/>
    <dbReference type="OMA" id="REPNTKK"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000030">
        <property type="entry name" value="AP-1 complex subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017107">
        <property type="entry name" value="AP1_complex_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037094">
        <property type="entry name" value="AP1_complex_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="11">
        <location>
            <begin position="683"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR10546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="803" mass="91881" checksum="0E4478A7CB2019B1" modified="2013-05-29" version="1">MGTLKQFIKSVRSAKTAADERAIIQKESAVIRAFFREESNNHYYRRNNLSKLLYLYILGECTHFGQIECLRLLASPLFADKRLGYLGTMLLLDENQEVLMLVTNSLKNDLNHPNPYIVGLALCTLGNIASPETARDLFLDIEKLMDSPNVYIRKKAALCAMKIIRKVPDFLENFIDHSKSLLKDRNHGVLLCGLTLIIDMCIHNPSIIKYYRPLTSYFVKHLKSLVNFGFSLEYDVSGITDPFLQVKFLRLLRVLGHGDIEVSEQINDILAQVATNTESSKNVGNSILYETVLTILDIEANKGLRVLGVNILGKFLSDNDNNIKYVALNTLSKVISIEPNAVQRHRSTVLKCLRDPDISIRRRALDLSFALINESNIRILVRELLVFLETADNEFKLNMTTQISIAANKFAPNKRWHIDTILRILRLAGNYIKEHVFSNFIQFIITTPELQSYTIRKLFFSLQKDITQEALTLAGIWMIGEYGELLLQPYQSFEEELNDVVKESNIIELFKNIIDSTHCSKTIMEYLMTSLMKLSVRIKDQSQIEKIRNLFGKYSTSIDVEVQQRSMEYERLFQFDEIREGVLEKMPPFVIKDSEMFDFSTRKLKSRKEADEDPLFDLLDGDFFSKKDSNDINNNKSAILDILGSLNHCESKDTEKNVSVSVQNPELLGIGVDFTSYKFNETTGNDIYTVYEKNGLKFTLQIDSLHISDMCTIVITNRFLNVGLTQISKINLQAAVIKSQKLQMYPISGTFIEPGGNLMQTMKITASKGSLLRLRFKILYNCYELGDVVEQVDFNQFPHNLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUF7</accession>
    <name>M7NUF7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872796.1">
        <property type="nucleotide sequence ID" value="XM_007874605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUF7"/>
    <dbReference type="STRING" id="1069680.M7NUF7"/>
    <dbReference type="GeneID" id="19894583"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00885"/>
    <dbReference type="eggNOG" id="KOG0893">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112570_1_1_1"/>
    <dbReference type="OMA" id="EVWKQGI"/>
    <dbReference type="OrthoDB" id="9739313at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.440.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="14358" checksum="725FA32F9B494DBD" modified="2013-05-29" version="1">MGFRKKKIATRSAISDVVTRDYTIHLHKRLHGCSFRKRAPRAIKCIRKFAELHMGTKDVRLDPQLNKEVFKSGIKSVPHRMRLRLSRKRNDQENAKERLYTYVQAVNVSNRAKGLQTTVVENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUK6</accession>
    <name>M7NUK6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00594</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-actinin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR10992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872490.1">
        <property type="nucleotide sequence ID" value="XM_007874299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUK6"/>
    <dbReference type="STRING" id="1069680.M7NUK6"/>
    <dbReference type="GeneID" id="19894292"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00594"/>
    <dbReference type="eggNOG" id="KOG0035">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005217_0_2_1"/>
    <dbReference type="OMA" id="QQRWITV"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21215">
        <property type="entry name" value="CH_SpAIN1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000223">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000030">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000077">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="10"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="125"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="353"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="641" mass="74158" checksum="C8D21095CC564E3C" modified="2013-05-29" version="1">MSLLDRSWQDVQHKTFTKWVNTKLSAHELPPAVSLKTDLSDGIRLINLLEIIGDETLGKYNKNPRLRIQKAENVNKALDYIKSKGIPLTNIGAEDIIDGNLKLILGLLWTLILRFTIADINEEGYTAKEGLLLWCQRQTAEYENVNICDFTTSWTDGLSFCALIHKHRPDLLNFHELDAKDHRKNISMAFEIASKYIGIPQLLDVEDICDVSKPDERSVMTYIAQYFHAFSTLDKVETAGRRVEKFAKTMQSASSMQKEYEEKMKDLINSIIKIQTLWDMSSFDDSYADAKHQSSEFNEYKKTLKRDWVKLKHDLESLIHDIQTKLRTYCLRSYIPPKGLELNDLDIVWKGLMKAEVQRSKQINDKIKEIKEKLRQSFAERANDFSLMLNTLSIEISGLKGDLEEQLEQINLLKEHIKPLRNELLQLKRLEEECKEAKIEENDYTNFSYDDLEYELDLASDLIHKKLQFIENQIITRQKTNLTSAQMKEFDSVFKHFDRYGINALQGDVFTAALAALGLAYDEQEMEDIIAKASNETGVVTYNQFIDFLVDEMEDHDSPDQVLLAFRDVADGKPYVTELDLRQSLIPPTEVEYLISQMPELQENETEIDDEDRGCPIFDYCSYMEKLLDLNDATINNKNNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUM3</accession>
    <name>M7NUM3_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872841.1">
        <property type="nucleotide sequence ID" value="XM_007874650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUM3"/>
    <dbReference type="GeneID" id="19894627"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00929"/>
    <dbReference type="HOGENOM" id="CLU_2777005_0_0_1"/>
    <dbReference type="OrthoDB" id="5348131at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="69" mass="7918" checksum="2F096BB00E6A47E0" modified="2013-05-29" version="1">MKVFNLRLSDIIHRSLVVFLSGLSVYGTVNVGYLLYKRKKKLKIIEDQIREGLLPPTPVKKSTSHDKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUR7</accession>
    <name>M7NUR7_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00987</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872901.1">
        <property type="nucleotide sequence ID" value="XM_007874710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUR7"/>
    <dbReference type="STRING" id="1069680.M7NUR7"/>
    <dbReference type="GeneID" id="19894685"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00987"/>
    <dbReference type="eggNOG" id="KOG1961">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010797_1_0_1"/>
    <dbReference type="OMA" id="IHVVMVE"/>
    <dbReference type="OrthoDB" id="19482at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007258">
        <property type="entry name" value="Vps52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048361">
        <property type="entry name" value="Vps52_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048319">
        <property type="entry name" value="Vps52_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190">
        <property type="entry name" value="SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190:SF7">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20655">
        <property type="entry name" value="Vps52_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04129">
        <property type="entry name" value="Vps52_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps52 coiled-coil" evidence="6">
        <location>
            <begin position="54"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Vps52 C-terminal" evidence="7">
        <location>
            <begin position="243"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="555" mass="66164" checksum="F90D7092408ADA3C" modified="2013-05-29" version="1">MEKSKIFIRNLDRIMTESSKWGFKDIEMSFFDSDRTSDERKKEDLNIKKISKKYIREMNTVESLHSYIMSSDKALDSLESYLFCFRNDLNEIDNEIKALQFRSIVLGQQLQIRKDAEKRIRNIVENFIISPETIYHISESKIDEKWQNNLSILNNILENFDSNKKKGNISKIQEHMEKQLEKLLWIAAERIREFFINKIKILHNPCSNSKAIQQCIINYKFLFSFLYKTQKQLTSEVKQIYQNTMQWYYSYNFKRYTNFLEKLKINTFDTFVLDSEKTSKKNNMHFQKGICIFSSYKEFNISHRASIVLGEDQNIIITRISNQDKKIYNLENIFYSYNQVLINNIVIEHFFLSEFMLFNSRQELNNYLENVIKCTLSNSMKFNQQLIKNSYNVLDILLCIKVTEKLVLILKNKEISILDNYMNEILALLWYQFQNSIDLHCKNLNQLSIKNTLLENYNRTSPDIITQIFGDLLNGIFILFSQDYNELIEENVEKLVNSYKIYLTKINNKIKSEEQEQFLYNNYSLILAIIGNTKGYLAKKQQAHFHELQLNIKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUT5</accession>
    <name>M7NUT5_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_00664</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872564.1">
        <property type="nucleotide sequence ID" value="XM_007874373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUT5"/>
    <dbReference type="STRING" id="1069680.M7NUT5"/>
    <dbReference type="GeneID" id="19894362"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00664"/>
    <dbReference type="eggNOG" id="ENOG502QWHV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_487548_0_0_1"/>
    <dbReference type="OrthoDB" id="5554151at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053088">
        <property type="entry name" value="Beta-glucosidase/SUN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005556">
        <property type="entry name" value="SUN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31654">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE ADG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31654:SF0">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE ADG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03856">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082311" evidence="4">
        <location>
            <begin position="17"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="372"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="511"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="341"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR11067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="559" mass="61704" checksum="A8311E9CF766DBDA" modified="2013-05-29" version="1">MIIIRTSLLFMAITNAYPAINPLARYDHRTSSDSHEVYQGRCSIFDPTLSIHPFTLSDGESRLLNCSPGNDCLYVCKSGYLPSRLDSRVNYDLMGVPGGKVSCDSQGILGLTPGVPLCLPSKQNIYVTSLLRLPSSFCQKVSFEGNSFFSPNFLQPRLLSSIAVSDNSYGSSLYYFNSPGVASQHECSTDFSTTGTGASSPYVLEVTKDPNNHVLIRLGWNPFYVTDDYLNKHSPGWGMKVLCEGVDCSQPCYIDPIRHAVNQCENCEQGYGGSSFCTVKVPENMEAVVFLFSSDNGQHTNSFTGFSSFEKTHKFSVTGRVQTSGFRETLDSKGLAYTGKDRNEKSEVDKLKQEDEELTKKEKELLEEAQRSRIENKLPGNQDEQFHQQGGSKHDDSRLFSTESAKEFMHHENNLKSSLNGVKNEDAVDLVYLKISGGNNKDIDDFKGFLDEKSLSLNKESAKDTGALNDVSSSISTGNSLCKTDKCKSLLTSITESAYELCSLLKSEHSSSNLSKKSSNPQLKVAPTDLESSKQENSATDIKTNTHWILILLGIIMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUW2</accession>
    <name>M7NUW2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01042</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872955.1">
        <property type="nucleotide sequence ID" value="XM_007874764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUW2"/>
    <dbReference type="STRING" id="1069680.M7NUW2"/>
    <dbReference type="GeneID" id="19894740"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01042"/>
    <dbReference type="eggNOG" id="KOG1919">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_12_4_1"/>
    <dbReference type="OMA" id="QTYCKGR"/>
    <dbReference type="OrthoDB" id="424794at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02557">
        <property type="entry name" value="PseudoU_synth_ScRIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="4">
        <location>
            <begin position="157"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR10896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="425" mass="49994" checksum="6722B0FAD5D9CEA5" modified="2013-05-29" version="1">MYKKIILKVVQLDFNFNSLYKKFYQFHGYCSQMSLKHRKEETRKKSQLEYKYNPLENACYTFDNGLRKVVPYFFNFKTYAKERWRGRTIYDVFSKEFRDRTPQYYEQEIKNGNVIINGRIATFEQIIKNGDIIEHLSHRHEPPVTDKKIDIIYQDDDIVVINKPPGIPVHPTGRYRHNSITHIMMAEMGFDSLAPCNRLDRLASGLMILARNVRIAEEMRKKMHDRRILKEYICKVRGLFPEGEIVCTEPLLTVSPKLGLNRVHPDGKPSKSTFKMLGYDGENSIVHCRPLTGRTHQLRVHLQWLGKPIVNDPVYSDIGIWGYDMKKNDTFTFNDNELFPSLIKSKKIEASSWYINKIEEAERLRGNKLDELLTGEVCDVCQAPLYSDPSQNDLRIYLHAWKYKSDDNSWSFETELPEWANIDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NV52</accession>
    <name>M7NV52_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
            <ecNumber evidence="12">2.4.1.132</ecNumber>
            <ecNumber evidence="12">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_00766</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10 12">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11 12">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="12"/>
    <dbReference type="EC" id="2.4.1.257" evidence="12"/>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872668.1">
        <property type="nucleotide sequence ID" value="XM_007874477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NV52"/>
    <dbReference type="STRING" id="1069680.M7NV52"/>
    <dbReference type="GeneID" id="19894464"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00766"/>
    <dbReference type="eggNOG" id="KOG0853">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030619_0_0_1"/>
    <dbReference type="OMA" id="AMYMKCP"/>
    <dbReference type="OrthoDB" id="448893at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="14">
        <location>
            <begin position="12"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="13">
        <location>
            <begin position="288"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR11172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="387" mass="44857" checksum="E591710942E7DA44" modified="2013-05-29" version="1">MKIAFVHPDLGIGGAERFTVDAAIGLQDLGHKVVIYTSHCNRNHCFEEIKKGLLSVKVYGDRIPSKIFGKFSILCAIFRQLYLSLVLFFKIESYDVIIMDVLSFGLLILRWKCLKILFYCHFPDKLLASRNNILRRIYRFPFDLIENLTLLMADKILVNSYFTASVVRKTFSNIKNLTILYPSINIYENDNSLEKSPLITQSHLYFILSINRFERKKNIDLAVKSYSHLKKDSNFNKCCLIIAGGYESRIKENVQYHNELLDLCNHFSFKSKTFMHPYKFPLDFSGYNVVFLLSIPTNLKNYLLQNATILLYTPPYEHFGIVPLEAMFHQTIVLAQNNGGPLETIDDGVTGWLKKPNETEWAEVLRNVLFQMTDAQRAIMGEKWHKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVF0</accession>
    <name>M7NVF0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00283</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPI10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872154.1">
        <property type="nucleotide sequence ID" value="XM_007873963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVF0"/>
    <dbReference type="STRING" id="1069680.M7NVF0"/>
    <dbReference type="GeneID" id="19893981"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00283"/>
    <dbReference type="eggNOG" id="KOG4067">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084839_1_1_1"/>
    <dbReference type="OMA" id="WWAKFER"/>
    <dbReference type="OrthoDB" id="10248398at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048364">
        <property type="entry name" value="Hikeshi-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008493">
        <property type="entry name" value="Hikeshi-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031318">
        <property type="entry name" value="OPI10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925">
        <property type="entry name" value="HIKESHI FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925:SF0">
        <property type="entry name" value="PROTEIN HIKESHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21057">
        <property type="entry name" value="Hikeshi-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05603">
        <property type="entry name" value="Hikeshi-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hikeshi-like N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Hikeshi-like C-terminal" evidence="3">
        <location>
            <begin position="150"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR11252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="216" mass="24131" checksum="90A44193B454A35D" modified="2013-05-29" version="1">MFGVICAGRPIQTNIQQIENNKFIFVLENAASINHIIIFLLPDNFFQEDFGATVYLQYPGKQFQLLGGLSNKKPSAIFRLRNISNSSNTNSEMEVMQDVSESAQSVAAVLGISIEPLLSVEQQLSSLSMAQQDQKKLQKSVEVSRPAPPIQVIVQRIVTNLYNFIVGFTTSQLPHGSQLLGNAQIDNTFIPLKAFQDWHSKFSSKLSMDPHFLEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVG7</accession>
    <name>M7NVG7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00732</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872633.1">
        <property type="nucleotide sequence ID" value="XM_007874442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVG7"/>
    <dbReference type="STRING" id="1069680.M7NVG7"/>
    <dbReference type="GeneID" id="19894430"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00732"/>
    <dbReference type="eggNOG" id="ENOG502S1WJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_621302_0_0_1"/>
    <dbReference type="OMA" id="HKRDICY"/>
    <dbReference type="OrthoDB" id="4703at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052416">
        <property type="entry name" value="GTF3C_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR11136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="49643" checksum="507BC545D6BFBA00" modified="2013-05-29" version="1">MEDEELNNVNGLILDDYLKASLPLKVYIGTYEASKLHIIERFSFYSLKKAYPLKTGYIIHAGFPIWGLDWCPGHLEGKQYLAVSGHPDYETHSTLLYATKPKKSAIQIWSFLPGSNDGLCNNPQLEIFIFHAFGSVWDLKWCPLTSKIDGKLGFLAAIFGDGCARIFSIPLSNKTNETLYMKLEQVKLSLKIHDTRCTCLCWISSNRIAIGASNGQICILDLEKKDPNIPIISFFAHSSYIRNIASCSPSYPNLLISSAYDCTVKITDIRDPLGDIAFIQRQRAMNFILQWWDELSCIILSDNMCGLRFIFFQTLQSSNHIISLDGTLWAVAMSPVHPFVAVAGADGTISIVNFIRKTFSKLRQPLSIRRIYQLSVNYQDMSYLLVESFKPEKYQKINSNPIIFPPEIGITVASWNPTKKYGGWLASGSASGILRVEDLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVV4</accession>
    <name>M7NVV4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribosomal protein/NADH dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_00461</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872343.1">
        <property type="nucleotide sequence ID" value="XM_007874152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVV4"/>
    <dbReference type="STRING" id="1069680.M7NVV4"/>
    <dbReference type="GeneID" id="19894159"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00461"/>
    <dbReference type="eggNOG" id="KOG3446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110897_1_0_1"/>
    <dbReference type="OMA" id="FIEQQYV"/>
    <dbReference type="OrthoDB" id="10250268at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016464">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B8 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005822">
        <property type="entry name" value="NDUA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR11442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="92" mass="10824" checksum="99ECE56D03B8182C" modified="2013-05-29" version="1">MGRYVLPKHIKELRFHLCQISEESKNTRLFIRKAYPILKKNNPYIPVLIREALGVSPMLWVRYEYGKEENLSLEGLSVKECKERVNSLLFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NW39</accession>
    <name>M7NW39_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00533</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872423.1">
        <property type="nucleotide sequence ID" value="XM_007874232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NW39"/>
    <dbReference type="STRING" id="1069680.M7NW39"/>
    <dbReference type="GeneID" id="19894231"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00533"/>
    <dbReference type="eggNOG" id="KOG4547">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023936_0_0_1"/>
    <dbReference type="OMA" id="CEHAVNP"/>
    <dbReference type="OrthoDB" id="30195at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052414">
        <property type="entry name" value="U3_snoRNA-assoc_WDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="131"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="6">
        <location>
            <begin position="475"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="661"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="674"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="711" mass="79707" checksum="AF776805615AF7C4" modified="2013-05-29" version="1">MVRKSSKSKRIRQVDTRTPINKISSVLISAFHPKKKFFAVAMNVLDAHNICIFDVVSGLLKTSFSLDKGLICRSLSWGIEFGYDNKTTLKKRRAEDGDTYSNEKDVLYLCLSNGEIFLFSITLNKIYMKLMGGHTQSVTGFAFSNDFKIGWSCGLDGKIVEWDLLTSKILNTFSFELLDSLTAIIYYNSKIICASHNIYILNLPLLDISQTFNAHITHVDSLLVCSDSNGSICCFSASKEDRFINMFLLNVEKNDVSVLVTEDNVKTLSFSTFFDMTILAVLTTSGIVNIFHDLFDKSFIGIFKQKKSLIRQPISKIIAFDESTSTQIEIVDIGIKDDNIIIVLVNGVTFIFETVSYLDNDKNFKQGEIHVFLKKSDFLKIHVNGVSKPNIKSYNESNAAVIDGDDMRNLDDDETSQSSEDIQSEKDVSKAINELSLAEKLEELEMKSSKPPEISVEVPSAKSLISLLMQALQVNDKTLLESCLNCQDSETVMATIKRLESPLAVLLLERIAERLSKRPSRASSLSIWIRWTIIIHGGYLVTLPNLMKTLSTLQLTLLRRASALPRLLALHGRLDMINAQIKLRKEYEPQNEESESGIEYVEGEDDSDEDMLAIDDTMHVKTLNNNNDNDGNIYEIDGSDYDTIDDNSLKNSNSPIDELLTEEVSDELSSNEISGDEIGEDEIEDEAGDDDLEVFGSASDSDYETIIEKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NW90</accession>
    <name>M7NW90_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TBP-associated factor 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_00424</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872302.1">
        <property type="nucleotide sequence ID" value="XM_007874111.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NW90"/>
    <dbReference type="STRING" id="1069680.M7NW90"/>
    <dbReference type="GeneID" id="19894122"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00424"/>
    <dbReference type="eggNOG" id="KOG1932">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002317_2_0_1"/>
    <dbReference type="OMA" id="EQPDYQW"/>
    <dbReference type="OrthoDB" id="308861at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09839">
        <property type="entry name" value="M1_like_TAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000011">
        <property type="entry name" value="Transcription initiation factor TFIID subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057345">
        <property type="entry name" value="Ig-like_TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037813">
        <property type="entry name" value="TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057991">
        <property type="entry name" value="TPR_TAF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25316">
        <property type="entry name" value="TAF2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25577">
        <property type="entry name" value="TPR_TAF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="10">
        <location>
            <begin position="356"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 2 Ig-like" evidence="11">
        <location>
            <begin position="570"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 2 TPR repeats" evidence="12">
        <location>
            <begin position="754"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR11401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1187" mass="136853" checksum="4BB535A2A784B941" modified="2013-05-29" version="1">MSDIDNDETCIGRGFTITHQKVMIDVDFINRNLRGCTEMTIVPTDPLLRKIRINSYDCDIISIHINEIEASFEYLFSKNELKLYKRSSVHQHHLLRKKFEAFHATFEYGNLSINIPKSIKIESKKNNETCTQTEEKEKDPNNSNDQISTKGNIFSLFLPIVIKINYSVKNPSTGLNFVGCDIDDNKYPHVFTTHVPISAATSNWLPCIEGIWDRCTWDFEITVPKTLRDMWILSDSSKSLNGNHVYYNNDTIDNGNLLNEPNDHLEFKVICIGDQLDEFTTPENNHKKTVCFSLGSLVSSQFVSFAVGPFDEINLTNFCNTDKDDTMGCDSVEVLGYCLPGRVLELRNSCMFIYKAIDFFVREYGSYPYNVFKLCFVDDHPTSAVPCASMVIANNNLLFPPDIVDPIYSTTRILTFALANQWIGVNIVPKHWNDIWLTIGLAYYITDLFLCKLMGNNDYRFRLKKAAEKVCEEDIGRPALTDPKLSPPIDPFSIEFISLKAPVVLYILEKRLTKSGPSWGLSRIIPKLFLQAMGGNLINNTLSTSHFLKVSEKVSRISLDIFAQQWIHGQGYPRLRIIQRFNRKKMLIEIGIRQVQDVETPSKPLTVTSFFDDAKYYVDNISNPSPLPVFTGTMTIRIHEADGTPYDHVVEIKEAFTKLDIQYNIKNKKLRKNQSKKQKKDIMDIDGLGDIDNDNDFGVQYFGNILQSEQEMKDWKLEEWPKEDEEKMSDEAFEWIRFDADFEWICLMWVNQPDYMYFSQLRQDRDVIAQYEAVQYFSNCKANSAYSTILLRTLMDSRYYYGIRCEAALALVKCATEELNWVGWFHLFKAFQTNYCFPNSSISKSNNFSNLSEYYIQCIIPVAMSKIRDKNGNSLTQVKKFLADLLRYNDNSTNKFSDSYYICTLINSLASTLITENKESFEYNFNLNNPENKSIIETILFEIERLQKIDQLLPSFQNIISITSLKIKYNLSKAGIILLDFQEVLRYTRLANYSLVRLTAFDILLKLGGLRQGPFTRYVFSTIFNDKSPIIRRYLSYSVSEALALMALNDQQNQTPVTTEQMIIEDDIDKAIEQKKKILVRANISGAITALRQEVMEEETLKEELWACVNSDKLDYVIRLNFLNIISLLFDPKESRVITLKIPNSRPRLTAQIIGEGKLIIRKEIAEKEPTENKKLPKIKIKISNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWS3</accession>
    <name>M7NWS3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein BZZ1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_00047</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in endocytosis and trafficking to the vacuole. Functions with type I myosins to restore polarity of the actin cytoskeleton after NaCl stress.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the BZZ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871901.1">
        <property type="nucleotide sequence ID" value="XM_007873710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWS3"/>
    <dbReference type="STRING" id="1069680.M7NWS3"/>
    <dbReference type="GeneID" id="19893745"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00047"/>
    <dbReference type="eggNOG" id="KOG3565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015390_1_0_1"/>
    <dbReference type="OMA" id="YADGWWE"/>
    <dbReference type="OrthoDB" id="8783038at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045010">
        <property type="term" value="P:actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20824">
        <property type="entry name" value="C1_SpBZZ1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11912">
        <property type="entry name" value="SH3_Bzz1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000060">
        <property type="entry name" value="Actin polymerization protein Bzz1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035459">
        <property type="entry name" value="Bzz1_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057870">
        <property type="entry name" value="HR1_TOCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF21">
        <property type="entry name" value="PROTEIN NERVOUS WRECK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25610">
        <property type="entry name" value="HR1_TOCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="F-BAR" evidence="13">
        <location>
            <begin position="6"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="12">
        <location>
            <begin position="407"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="11">
        <location>
            <begin position="527"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="11">
        <location>
            <begin position="618"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR11606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="669" mass="76572" checksum="B5F3FD942B3B44B8" modified="2013-05-29" version="1">MESQRTSFGEELKESRSLNMKICIVNNGIKWLDDLQSFYRERSIIEKEYSLKLASLSRKYHEKKGKRSTSLSVGDNPKMTPGSLESASVTTWENILNHTENLAKERQIFSEELQTQVVDKLKALAIKSDDLRKKHVVFSERLLEERERIYMELKKMKLKYDEHCHLVENSRQKHEKSSEENKTKAKKIYNQNILNMNNAKNNYIIAIHVANAHKNKYFFSDIPDILDSMQDINELRIQSMNSIWTTAAHLEISTFSKCKNHLNDLIKFVGKNDPILDSTMFVHHNVSSWHEPPDFVFEPCSIWHDSDQMIADDHSIIFLKNKALRSRIKLLQLQENVDTKKREINGLQNLREVYSKNPNLGSQDEVTNNLLDARREVAFMDNRRLTLEIEVNIISNIIGEIDTNILLHDFKPSSFTIPTNCDCCHSTIWGLTRQGLTCKFCNYNCHFKCEMKVSISCPGKKEGKKTRKTKEVLESQNFGKNTSSSLSPSFKNIDLDKSSSHEKIPSHSPLKTTMLMNQSHISLSSSSEKQIAKVLYNYVSGSNTELSVKEGDEIIVLEKDDGSGWITARLGSQEGIVPTTYVKMLNSQGFISNESVSSTLVKPEKKSGPAVVPRRAKKKEIYVKALYNYDAVSDFEISIKRGDLIKLIKSDQGDGWNEGFTSTLTNYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWZ2</accession>
    <name>M7NWZ2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GED domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871976.1">
        <property type="nucleotide sequence ID" value="XM_007873785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWZ2"/>
    <dbReference type="STRING" id="1069680.M7NWZ2"/>
    <dbReference type="GeneID" id="19893816"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00118"/>
    <dbReference type="eggNOG" id="KOG0446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008964_5_0_1"/>
    <dbReference type="OMA" id="MLEPCKQ"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034643">
        <property type="term" value="P:establishment of mitochondrion localization, microtubule-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015886">
        <property type="term" value="P:heme transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097753">
        <property type="term" value="P:membrane bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090149">
        <property type="term" value="P:mitochondrial membrane fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140572">
        <property type="term" value="P:vacuole fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF235">
        <property type="entry name" value="DYNAMIN-RELATED PROTEIN DNM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GED" evidence="1">
        <location>
            <begin position="454"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="541" mass="61919" checksum="6D60AEE9E05AC742" modified="2013-05-29" version="1">MDHGTNALDILLGRVYPLKLGFIAVVNRSQQDIITNKSLKDSLRFERDFFCNHPIYKNISHLCGTPYLVKSLNIILMQHIREKLPDIKAKLITLMEQTRQGISSSDSQCLIAKNKGSALLYLINGFSNAFISSIDGSSSEISTKELCGGARIYYIFNNIFKHALNMIDPTENLTVQNIRTAIRNSSGPRSSLFVPGLAFDILVKPQIKLLEIPSRRCVELVYEECVKVCYACCNNELERYPRLQAKLVEIMSDLLRERLEPTSNYVESLILIQMAYINIDNPNFVDRMGLISSIFQDSNKDKKNIKADKKETDNKRRVSGNIIATNGILESSRSVPNDLTNNIVQNNTCSRETGVPGFELNSDFALQSGIFSNSIGHINSSDIKELFFNFFSNDKKEYTKTPRSSIPFSEKDLNTLKYPDNSISHDIVSLNKDSLDIVDSDYDENMTERQQLEVNLIRSLIISYFNSVRETIQDQVPKAIMHFLVNYCKKCLQNKLVTELYREEFFDDLLYEDETLTMEREKIQKLLNVYKQALKYINEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NX49</accession>
    <name>M7NX49_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat WDR3/UTP12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872031.1">
        <property type="nucleotide sequence ID" value="XM_007873840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NX49"/>
    <dbReference type="STRING" id="1069680.M7NX49"/>
    <dbReference type="GeneID" id="19893868"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00170"/>
    <dbReference type="eggNOG" id="KOG0306">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005318_0_1_1"/>
    <dbReference type="OMA" id="MNIPLTC"/>
    <dbReference type="OrthoDB" id="407922at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000157">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000178">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25173">
        <property type="entry name" value="Beta-prop_WDR3_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25172">
        <property type="entry name" value="Beta-prop_WDR3_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="110"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="207"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="403"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="484"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="580"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="657"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="7">
        <location>
            <begin position="793"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR11736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="928" mass="107215" checksum="D7E5AE7203640A30" modified="2013-05-29" version="1">MVKSYENYEFGFSWGIIASYLSNSVLVDDKEISEKFKAKNGLAIVPALEDVIIWDIKKGEEVLRWSDFDCKVETTSIKRNMADKYMFAVGYEDGSIRLWSLEKKQVLMKLNGHRSSVTVLTFDITGTRLVSGSKDTDIIVWDVVSETGMYRLRGHKDQVTECVFLRTPLNEIGFVDPIKDHGWIVSVSKDSFIKIWDLSTQHCVETHIAHQGECWALGVSPDQKICVTAGLDGELKIWDIQSDVLAIRSESVPETNYRLTLKCTLTRQSKERPITIAFHPIFDMFACHGSDKIIEIYKKRDEKELKKVLSRRKKRNREKHNDSNKDISLLPEDEIVLYTTIRTSSKIRSIDWGTLGQNPFKKKILQLLVSFSNNVIRIYDIPIVAKIDYSEPPEYLQTFSIEMQGHRSDIRSLSIDSNDEMLASVSNRTLKIWNIKTGRCIRNLDCGYALCCSFCLENKYVIVGTKEGYLEIFDIPSSTMVERILAHKRSIWSLKIHPNGQGFVTGSSDKSVKFWDLKIIKDLSDKEIMKLHIKEMRILNLTDDVLSVCFSPDGRLIAISLLDTTVKVFYTDTLKFFLSLYGHKLPVLSMDISSDNKLLVTSSADKNIKLWGLDFGDCHKTLCRLHLKKKGHNFFSTGKDKLIKYWDGDKFENILKLEGHHSEIWALAVSNDNKFIITGSHDRSIRIWNQTDEPIFLQEQKEKELEKFYEKDLVEKMDKYEMNENKKIDELASAGKQTLESVMAGEKIIDALDIGIKDIELIKEHEEARKNNDKLKNPTRNPIFVANENISAEDYVLNILEKIDSSHLEDALLVLPFKSVTYMLTFINLWAEKGSNIQLICRILFILLRVHHQQIVANKTIRYMLDSIRIKLREELQVQKDMIGYNLAALKYIRQSWEIHHTKEFYNEEEYRKQLESGKKRVFSALEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7P2B0</accession>
    <name>M7P2B0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase 9.5 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875552.1">
        <property type="nucleotide sequence ID" value="XM_007877361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P2B0"/>
    <dbReference type="STRING" id="1069680.M7P2B0"/>
    <dbReference type="GeneID" id="19897149"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03462"/>
    <dbReference type="eggNOG" id="ENOG502S74C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166990_0_1_1"/>
    <dbReference type="OMA" id="EKPAIFW"/>
    <dbReference type="OrthoDB" id="2093409at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22903">
        <property type="entry name" value="NI9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039961">
        <property type="entry name" value="Nuo9.5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8874" checksum="E4B4CEF7A0A7B87C" modified="2013-05-29" version="1">MPSITSFWSGSIKYIYQTAEEKPHIFYSFLLGSLGPIIFFLVPPIRKKLGYVPPEPIPRTYQLPKRKREILEGYDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7P2M3</accession>
    <name>M7P2M3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_03573</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875666.1">
        <property type="nucleotide sequence ID" value="XM_007877475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P2M3"/>
    <dbReference type="STRING" id="1069680.M7P2M3"/>
    <dbReference type="GeneID" id="19897260"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03573"/>
    <dbReference type="eggNOG" id="KOG0027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061288_13_1_1"/>
    <dbReference type="OMA" id="HDQASTN"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071341">
        <property type="term" value="C:medial cortical node"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="3"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="74"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="141" mass="15769" checksum="457146A16B54542C" modified="2013-05-29" version="1">MDSSNVAYKEAFSLFDKYGKGTVSKECIGDLLRAVGQNPTLSEVSEIEESILDEVTFDTFLRILNRPNGFRPVSDHADFIRGFQVFDKDSTGFIGVGELKYILTNLGEKLSDDEVNELLKDVNTKDGVVNYGEFVRMILSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7P330</accession>
    <name>M7P330_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_03408</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875494.1">
        <property type="nucleotide sequence ID" value="XM_007877303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P330"/>
    <dbReference type="STRING" id="1069680.M7P330"/>
    <dbReference type="GeneID" id="19897095"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03408"/>
    <dbReference type="eggNOG" id="ENOG502QVTM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DKYKFDS"/>
    <dbReference type="OrthoDB" id="338531at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052406">
        <property type="entry name" value="Chromatin_Remodeling_Comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970:SF14">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="5">
        <location>
            <begin position="18"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="RFX-type winged-helix" evidence="6">
        <location>
            <begin position="552"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="801" mass="91515" checksum="A3C2E6DE040FF8CC" modified="2013-05-29" version="1">MRGKGLIKITDDDDIERNEEYNEFIKDLEAYHIKRGTGTFVREPIIGPHRIDLLKLYKRVIELGGYDKVSSEKSWWKNLSNHYKLPPMSNAGYLLKSIYYKNLAAWEMEKHWKKTPPAPEHLEFQTAKGGDIMTRTAENYQVTTKEDIRLDSSSPMPLVRNLRAAPAPRTFYQPDERLTQARSALQKQAQQQLQMQAQQQPFSTHFATSTFPEDVNNKLQPQPVITPANTHALEYLRNSTYGSQNGTKIGAGIQGAPFMVRIALALKSGLVSELDWALHHLVRLSYEQGNNLRFDRIPDLAETLIKKLYEFLKQVSRKEMEFDEENDDWSMDYQSRKALDKILEAALILRNLALLSDNASYLARLEMTHPTLVLGIKQMDDFSFIELKHYCMDIIEAVSFYTIINDENDDLYLSLCELLQCDDRAMLIGALRALARLALHDTNNRLLQNISPYILYRVRLLLSLDDEELLGSALDFMYQYTTYKANTQSILELEDIHDLIDQLVRLMMFQAEEKEIHVSLSADIKQYIPTGPPPLPAEIVQELLGFGEPDRAVKWMRVCYQESSSDDITQMHLWQSYQARFSPFIAAGRPLLSAADLIKIASRAFPKAKAMVLNAPEGQSFIIRGVRPREIAISIKGESYVSCKWVVETNDSGICGSQFPNSQELFKHIIDHHLPEVRLLSSSAPPLVCKWFDCTRFTLPGEKDRFIVLSHLRTHIPDKLTQFVSSSLWENISIHTKTTAVDERGEAIGVALTATLILRNLAKSKHRQDLFINIENSIIHVVAQNPVLSTYLSELLVEIQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7P386</accession>
    <name>M7P386_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="8">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_03440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="8"/>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875527.1">
        <property type="nucleotide sequence ID" value="XM_007877336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P386"/>
    <dbReference type="STRING" id="1069680.M7P386"/>
    <dbReference type="GeneID" id="19897127"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03440"/>
    <dbReference type="eggNOG" id="KOG3742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015910_1_0_1"/>
    <dbReference type="OMA" id="RDVRNHI"/>
    <dbReference type="OrthoDB" id="6335297at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000014">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000045">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="679" mass="78234" checksum="EAD42F27419841F9" modified="2013-05-29" version="1">MDSEKLRDVKNHILFEVSVEVCNRVGGIYSVLKSKAPVTSLEYSYDRYIAIGKFTQSAINFEVEQLSTEDQPILHKTLQYMKNRGISYTYGRWLIDGAPRVLLFDIGNAFHWLNEWKGDLWNTTGIPSPPDDSETNDAIAFGYIVAWFLGEFISHEYERAVVVHFHEWLAGVALPLCRKRRLDLTTIFTTHATILGRYLCADNADFYNNLQYFDVDYEAGKRGIYHRYCIERAAAHSADVFTTVSHITAYESEHLLKRKPDGVLPNGLNVVKFAAVHEFQNLHATFKQKINEFVRGHFYGHNDFDLDNTLYFFISGRYEYRNKGVDLYIESLARLNERMKASDSKMTVIAFIIMPAATHSYTVEALKGQAVMKSLQNTIEHIQKGIGQRIFEKCCRHSKDFDEKFIDTSSLLTDQDKILLKRRVFALKRSTLPPIVTHNMADNNDPILTQIRRVQLFNSDDDRVKIIFHPEFLNSNNPILPLDYDDFVRGCHLGVFPSYYEPWGYTSAEAVVMGVPSVTTNISGFGCYMENIIENPSDYGVYIVDRRMKSVDESINQLTNIMYNFTTKTRRQRINQRNRCERLSDFLDWKIMGLEYIKARQLALRRAYPNSFDTDDLIDKNIDLSLGTLIKVPHPLSAPTSPKCRNGFLSIHNLDDIQNIQCLNTSEYATNKHSDNDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3I8</accession>
    <name>M7P3I8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="8">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_03242</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 8">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="8"/>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875308.1">
        <property type="nucleotide sequence ID" value="XM_007877117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P3I8"/>
    <dbReference type="STRING" id="1069680.M7P3I8"/>
    <dbReference type="GeneID" id="19896929"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03242"/>
    <dbReference type="eggNOG" id="KOG3355">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070631_1_1_1"/>
    <dbReference type="OMA" id="TWMCEAH"/>
    <dbReference type="OrthoDB" id="17199at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160203">
        <property type="term" value="P:mitochondrial disulfide relay system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000003">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF0">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="10">
        <location>
            <begin position="62"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR08405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="174" mass="20478" checksum="12BE2E06EF7C2608" modified="2013-05-29" version="1">MITKETVDISAEDKKDTPVSGNMSKNSCRVCVSFKKWMQNQNNSLFDKEKTSNLDNIDLTNCPPDSELLGRSTWTFLHTMAANYPELATAKEQVEMQEFLRVFAKHYPCFYCARDFREWMSRKENQVKANGREDLSLWICQAHNEVNRKLGKPIFDCFKWKERWREGWKDGSCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7P526</accession>
    <name>M7P526_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase MRP protein 1 RNA binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874766.1">
        <property type="nucleotide sequence ID" value="XM_007876575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P526"/>
    <dbReference type="STRING" id="1069680.M7P526"/>
    <dbReference type="GeneID" id="19896430"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02739"/>
    <dbReference type="eggNOG" id="ENOG502S2QW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1949728_0_0_1"/>
    <dbReference type="OrthoDB" id="5414547at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000294">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, RNase MRP-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22573">
        <property type="entry name" value="RMP1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047205">
        <property type="entry name" value="RMP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047204">
        <property type="entry name" value="RMP1_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37792">
        <property type="entry name" value="RIBONUCLEASE MRP PROTEIN SUBUNIT RMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37792:SF1">
        <property type="entry name" value="RIBONUCLEASE MRP PROTEIN SUBUNIT RMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20945">
        <property type="entry name" value="RMP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase MRP protein 1 RNA binding" evidence="1">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="RNase MRP protein 1 RNA binding" evidence="1">
        <location>
            <begin position="58"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="129" mass="15545" checksum="EDF9915A45041162" modified="2013-05-29" version="1">MIKKPNTNELNALWHNYEIICSIFYRNKNQHHGQVWWKYVSMLRQKLRVYFLLPLRLREQQQKKILTFIPNAYLYFSSIIAQGQFPKLGIVLFTIIASIRNIFWKDETFQENTQEIDSEDIGEVIDICF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7P557</accession>
    <name>M7P557_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Pre-mRNA-splicing factor SYF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02785</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">May be part of a spliceosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SYF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09010.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874816.2">
        <property type="nucleotide sequence ID" value="XM_007876625.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P557"/>
    <dbReference type="STRING" id="1069680.M7P557"/>
    <dbReference type="GeneID" id="19896474"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02785"/>
    <dbReference type="eggNOG" id="KOG2609">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051065_0_1_1"/>
    <dbReference type="OMA" id="RRRMHND"/>
    <dbReference type="OrthoDB" id="199717at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013260">
        <property type="entry name" value="mRNA_splic_SYF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264">
        <property type="entry name" value="GCIP-INTERACTING PROTEIN P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08231">
        <property type="entry name" value="SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0747">Spliceosome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="68"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09010.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="285" mass="34489" checksum="AD12363FE07B4670" modified="2016-03-16" version="2">MTNEKIMTKTGEKNGEYLENIDKEHVNNKGLKEFDERLGYPENLDNEEKSLKVKNRMDQLMNLRKRMRLSAEANRKDLFSEYQRLKEDPKLAKKIEFKRQDAEKKLEKQESIERGEDYERKRAWDWTIEESERWDQRMKEKQEARDKSLFADYTQVAQHSYEKLMRKFKPDLETYEKERAKVVANKTILDENDSEVTNTYESFYRDANFLGFANNKPSKKAIDRLIEDLNKQKEMRNKSRRRIDPDDEDVSYINERNANFNRKISRFYDKYTREIRESLERGTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7P651</accession>
    <name>M7P651_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">40S ribosomal protein S9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02280</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874274.1">
        <property type="nucleotide sequence ID" value="XM_007876083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P651"/>
    <dbReference type="STRING" id="1069680.M7P651"/>
    <dbReference type="GeneID" id="19895973"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02280"/>
    <dbReference type="eggNOG" id="KOG3301">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089738_0_0_1"/>
    <dbReference type="OMA" id="RQFITHG"/>
    <dbReference type="OrthoDB" id="1697570at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000021">
        <property type="entry name" value="40S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003139">
        <property type="entry name" value="PRK04051.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF5">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="10">
        <location>
            <begin position="6"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="9">
        <location>
            <begin position="107"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="190" mass="22391" checksum="D4A2B30B70793A0A" modified="2013-05-29" version="1" fragment="single">MPRAFRNYRKTYKVPRRPFESARLDAELRLCGEYGLRNKQEIWRNLLILSKIRRAARELLTLDDKDPRRLFEGNALIRRLVRIGVLDETKRKLDYVLALRIEDFLERRLQTQVFKLGLAKSIHHARVLIRQRHIRVGKQIVNVPSFLVRLDSQKHIDFALNSPFGGGRPGRTRRKKLSAKAEIDTAEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6G2</accession>
    <name>M7P6G2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SWI/SNF and RSC complexes subunit ssr4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874409.1">
        <property type="nucleotide sequence ID" value="XM_007876218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P6G2"/>
    <dbReference type="STRING" id="1069680.M7P6G2"/>
    <dbReference type="GeneID" id="19896096"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02403"/>
    <dbReference type="eggNOG" id="ENOG502S7WA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_639543_0_0_1"/>
    <dbReference type="OMA" id="QICTARF"/>
    <dbReference type="OrthoDB" id="5321006at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013859">
        <property type="entry name" value="Ssr4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046464">
        <property type="entry name" value="SWI-SNF_Ssr4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20497">
        <property type="entry name" value="SWI-SNF_Ssr4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08549">
        <property type="entry name" value="SWI-SNF_Ssr4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWI/SNF and RSC complexes subunit Ssr4 N-terminal" evidence="1">
        <location>
            <begin position="22"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="SWI/SNF and RSC complexes subunit Ssr4 C-terminal" evidence="2">
        <location>
            <begin position="282"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="49708" checksum="1D4B6DFAC055B0BB" modified="2013-05-29" version="1">MIETAQQYLVSSIPKPEWRTQVWCKSTLSYPVNPHLSIESITDMLLKAPGVVQKVPFVWNFIDKPVDGQIFLVWLSPESSMHPPPDGFQYMDSENCYRIDIGGNTVEIFEHKYGFYPMTESHTSRIRRRFRLVKGGNDQLWLIYYLRSSENDRLVVNSHTATPQPSRTYPLPFIQNKPFLLYESTTPQPSRSYNSVTSNVPTRPMMYYNNLTSVQGNQNFQKHQYTNQSGGTHSTATYNTQPNIPLFYDLKKKTKTNSSASTDHGSSNFQNPLLHHSKAISEEEEPQGDELDFLTPRDISIARYMRHHDWMEEIFNNTFKISNILSSPLFPKSEDYTIEALKEKLSNNEIQTMKDLHEKKINEIKFSNEAIWLKNAINDLNNAQNMEEIASVTKAVEEKLRKSVQKVSVKEIYIKETNKELENSEVFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6J6</accession>
    <name>M7P6J6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PNEG_02093</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874073.1">
        <property type="nucleotide sequence ID" value="XM_007875882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P6J6"/>
    <dbReference type="STRING" id="1069680.M7P6J6"/>
    <dbReference type="GeneID" id="19895787"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02093"/>
    <dbReference type="eggNOG" id="KOG0347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_13_0_1"/>
    <dbReference type="OMA" id="QMIQKAR"/>
    <dbReference type="OrthoDB" id="4310724at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="115"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="338"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMR09505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="609" mass="70376" checksum="F99F21D97DE66B79" modified="2013-05-29" version="1">MKRRYSITYILFFLKKRYIQEKIVDKNKGNRKKRSKSSIKAEISNKKQDTSRKDKQIEEKEDLALFKSESINNSEETNKTLDLPNWKDFNLSKIVLEGLSDLSFLSPTKIQRKAIASIIKGNNVIAKAETGSGKTLAFGIPVIDYIIKNNFCIVSALIFAPTRELARQIARHLESISKFSSLSIITIAGGLSIQKQERLLKRNPNIIIATPGRLWEIMNQNDGFIKMFSKVKFLVLDEADRLLQEGHFKELDDIFNTLKGYKDQMQVLVFSATFKKSLQKKINNIVYETSTSTQNEIELFLNKLKFKNKFDFIDTNPEESIPKKIKEGMIECENMDKDLYLYYFLLKYPGRTIVFMNSIDHVYRIVLMLNEFNINPLPLHSKLPQKRRLQVIEKFNENETSILIASDIAARGLDIFKIQHVIHYHLPRSTDLYIHRSGRTARAESSGVSILLCTPDETIKLKKMLFFLGKNADEMLSFPVDYSLLKKLKPRINLGRKITNVIRHINKQRHNYVWLKEAADDLGVNINELNSENDKEKNISKKDIQILRHQLKELLSQTLYSEFSQKYLTNGLNNIAQNIIQGKTHPTFLGTIKLDALDIFKKKMSNSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6W4</accession>
    <name>M7P6W4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_02214</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874197.1">
        <property type="nucleotide sequence ID" value="XM_007876006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P6W4"/>
    <dbReference type="STRING" id="1069680.M7P6W4"/>
    <dbReference type="GeneID" id="19895907"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02214"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_503545_0_0_1"/>
    <dbReference type="OMA" id="QIVCENY"/>
    <dbReference type="OrthoDB" id="942095at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="73"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="8">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR09630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="541" mass="62651" checksum="3B7FD5C7515FC14B" modified="2013-05-29" version="1">MDHPHIIRLYEVLYTEEHVWLVQEYCSGGELYDYLVKHTKLPEYETKTLFSQISSAVAYIHLHGSVHRDIKLENIFLTASGSAKVGDLGFVREQVTNKLLQTWSGTLAYSAPEIVNESINTEEKIDVWSLGVLLYALLCGELPFDDDDEGILRSKILNDHPKWKNDLSSEALELLQLMLAKNYKNRPTMIDVLKHPFLEPVGKEYLKYLKVQNLQHFSTNLEQDILFNMNMIGINVDMLKRSVIENKCDALRALWLLIKEKAEKSAGSSINKKSSKKQKKDKFFWLNILSQDMIKKKSFKKLFNLKDMFIYSKFSSYFYPKSTQNIIENDCRGISKKSHKHKDNIGLRVSILIIFKKWLISLLKYKNSKNEENLDTGISLNMQKHTCKNGNTLKKPRSYILHEVDEANTNLIQKPSILSLSLCISNRSKGSEALKNENNSYISNSKKKMPLKGLFKHLDCNTDKYIYPYENSISNPFNERIIHSDPSFLSSYKKLTAIKEQCNNYNESDTKLGNTKRLKKNEKAESRFLQKIVEEDETLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7P833</accession>
    <name>M7P833_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873757.1">
        <property type="nucleotide sequence ID" value="XM_007875566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P833"/>
    <dbReference type="STRING" id="1069680.M7P833"/>
    <dbReference type="GeneID" id="19895483"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01789"/>
    <dbReference type="eggNOG" id="ENOG502QW2I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022381_5_1_1"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF1">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="363" mass="42461" checksum="16E239CC186604AF" modified="2013-05-29" version="1">MPKIRKDVTVLSLILSLYLLVAYFFYLSNTNYTKYPNLLSKTHVDIRKQKKISYYSNELRYKESSRELRMTMFSTKTFENKPQTLYEHLAFQFPYKEQRFPDYIWQFWKYEPSDSNFDSRFLPLEASWKKYHNSSIYTIVKEEYAHYLIRHLYLSIPDVIKAYNALSTSILKANFFRYLILFARGGIYSDINTELLLPASNWISESIELSSIGLIIGIETDITSRPDTMQDNSEFFRFSSKTIRAKPGHPVLREIIVNITEEILQKKSTSKNSLKSTQFINSALWTNIIIDYLSSDAISSSKVESENISYSYLSKINKEMTIGDIVILPITSFSLNERYISSKTSESPQAILRHSFKDIKELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7P8P5</accession>
    <name>M7P8P5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_01492</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873432.1">
        <property type="nucleotide sequence ID" value="XM_007875241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P8P5"/>
    <dbReference type="STRING" id="1069680.M7P8P5"/>
    <dbReference type="GeneID" id="19895188"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01492"/>
    <dbReference type="eggNOG" id="KOG3071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048483_6_1_1"/>
    <dbReference type="OMA" id="WTYFTST"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF134">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR10220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="327" mass="38493" checksum="91ED543789D0BFE7" modified="2013-05-29" version="1">MISVERPFGIYLWSIFSKIWKKSIGYPVERFEFVAGKTYLSTWTEVLGLVISYYVVILVGKWIMRFFAPIKLNTIWQIHNLFLSIISGFFFLLLFEQMFPIVWNHGIYYSICNPKSWAQPVVTIYYINYLIKYIELIDTVFLFLNKKPLQFLHCYHHGATVFLCFTQLIGQTPVSYVPIILNLGVHIVMYYYYFLCARGIRVWWKKWVTRIQIIQFIFDLLFVYFATYTYFAYTYFPFLPNFGDCAGKEFAALVGCFLLSSYLLLFIGFYVATYKSKEGKVINKNLNKNIQSQSHKLNDISFKDLSNKVVNSTGVNSIGMTTRSRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>M7P8V2</accession>
    <name>M7P8V2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_01521</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873465.1">
        <property type="nucleotide sequence ID" value="XM_007875274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P8V2"/>
    <dbReference type="STRING" id="1069680.M7P8V2"/>
    <dbReference type="GeneID" id="19895216"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01521"/>
    <dbReference type="eggNOG" id="KOG1863">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003532_2_1_1"/>
    <dbReference type="OMA" id="HTAHHRF"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000005">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024729">
        <property type="entry name" value="USP7_ICP0-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029346">
        <property type="entry name" value="USP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF644">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14533">
        <property type="entry name" value="USP7_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12436">
        <property type="entry name" value="USP7_ICP0_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="10">
        <location>
            <begin position="59"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="11">
        <location>
            <begin position="213"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR10255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1123" mass="131474" checksum="88A2BDADFBED0E74" modified="2013-05-29" version="1">MNDLEENERLQGNPGILLTRIYGQAMELDQEEKTLKANEFEKMTMKLLPTLPDLETICETHFTWHVESWQSLGRKAYSPEFASGNFIWRILVFPFGNYQSDQFSIYLECQPSDRSASWYCCAQFCIVMWNKNDPSVWTHHYATHRFIPEESDWGFSRFYDLRKLMMRFEDRNHSIIENDETSITVYLRIVKDSTGILWHSFINYNSRKETGYVGLKNQGATCYMNSLLQSLYFTNFFRRAVYMIPTEKDEPNDSIALALQRLFYLLQTSSEPVSTIELTRSFGWDTLDSFMQHDIQEFNRVLQDNLEGKMKNSEAENALSKLFVGKMKSYIKCVNVDYESSRSEDFWDIQLNVKGMKTLRESFRDYIQVETLDGDNKYFAEGYGLQDAKKGVIFQSFPPVLHLQLKRFEYDLQRDTMVKINDHHEFPLEIDLEEFLSDDANKSKPHIYKLHGVLVHSGDLHGGHYYALLKPEKKGHWYKFDDDRVTKATLKEVLDENFGGDMSPTNNYIKNPYSRNSSLKRYMNAYMLVYFRENELDEILKPVVESDIPEHLRKRLESEKAALEARRKEREEMHLYLYVKIVTDEDFKAHQGFDLSNIEERDPPVCLFSTHKILKETLFTNFKMQIAENHGIDSKNIKFWVMVNRQNKTIRPDTPVPENDPTLTLEMIRDKMLPRKGDLLLYMELFSADSCDTLLESWNSLETQGNNAKILIFLKHFDIKKQLLHGVSHIYINKHDKIGTLISIICSLMDWPSTTLIQLYEEIKPTMIEMMKLKQTFYQAEIQDGDIICFQKVISEEEIEEILSDGGYGSAIEYYDFLLNKITLSFKPRYLDQDVTEEFDLVLSRKTTYDVLSFKVGERLNVPSTHIRFTTINSATQMPKFTVKRVPSLTLQNILQSAYLQSPLNILFYEVLEISLSELETKRTLKIGWLPDGITREELIEVLVPKTGILKDVVQALIQKLNLSSDLIDRFHIFGAHLNRVYKDFDLSYPVASLQDFLLLYAEMIPEDELNLEKDDQYINVYHFQKEPARSHGIPFRFIIKPNEKFNQTKARLLKRTGMKEKDMGKVRYAVIQQTSFAKPHYLEDDDVIYDILRNSDDLLGLDHLDKTVRTGRHGEKAIFIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7P925</accession>
    <name>M7P925_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01591</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873545.1">
        <property type="nucleotide sequence ID" value="XM_007875354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P925"/>
    <dbReference type="STRING" id="1069680.M7P925"/>
    <dbReference type="GeneID" id="19895286"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01591"/>
    <dbReference type="eggNOG" id="KOG0191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038617_1_1_1"/>
    <dbReference type="OMA" id="FINEHAG"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00238">
        <property type="entry name" value="ERp29c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1150.12">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011679">
        <property type="entry name" value="ERp29_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036356">
        <property type="entry name" value="ERp29_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF11">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07749">
        <property type="entry name" value="ERp29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47933">
        <property type="entry name" value="ERP29 C domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082722" description="protein disulfide-isomerase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="126"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="357" mass="41204" checksum="8BF79B39E46ED1DB" modified="2013-05-29" version="1">MKFIFFAIFLNILNIIRAKVLELTPETFYSVVGKDKPALVKFYAPWCGHCKRLEPIYDELSSLYQGKNIIIARVNADIYNELGKKFEIRGFPTIKWFNAGSLDAKIYDNDRNIQSFTDFIEKRTGIKARGSGSSLSVPELTPETFNEIVFDPKKDVLVKFYAPWCGHCKKLEPIYERIHKCFSSDKHVSIVKFNADYYKDFAKVYNIEGFPTLKLFLKGSLQKTILEYNGPNTELGIVSFINKNTGTSRVPGGDLSSIAGRINEFDAIIKEYKTSNERDILSKLKDLASKSNNNYGLYYVKVLEKAMQSADYVENEYKRLERLLKNNFERKKRDDIQIRKNILSVFRDKGKLMSNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAG8</accession>
    <name>M7PAG8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA mismatch repair protein MutL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00981</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872895.1">
        <property type="nucleotide sequence ID" value="XM_007874704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PAG8"/>
    <dbReference type="STRING" id="1069680.M7PAG8"/>
    <dbReference type="GeneID" id="19894679"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00981"/>
    <dbReference type="eggNOG" id="KOG1978">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004131_0_2_1"/>
    <dbReference type="OMA" id="SFNNVQY"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000017">
        <property type="entry name" value="PMS1 homolog 1, mismatch repair system component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="5">
        <location>
            <begin position="218"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="4">
        <location>
            <begin position="643"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="474"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="755" mass="86636" checksum="60CC98E389C8B38A" modified="2013-05-29" version="1">MLGEIQPIKNELKGYISSCQVITDLSMAVKELLENSLDARSTRIEIRLKNYGLNSIEVVDNGNGISIDDLECLAQQNATSKIREFENLDSLLLYGFRGEALYSLCRLSQVQIITATEKTEPQGIQIIYDQKAKILSKEIVPSCKGTTVKVEHLFSTLPVRRKEFEKNHKQDFQKALAIVQAYAIIKVGVKFLVTHQLPNKPKVTHISTSGNENLRENVANLFGANVLSTLVNMEFEMTILDLYKINVSGLISRPFFKEECLISKKQYVYINSRPCLLPQITRTITEIYKVYTVSQRPFIIANFIMPSDSYDVNVSVDKRTIFLHNEKEIISELKLHLNKLLQNISVDQNFFFSNQIPINNVSNISKNIVLEKKKVTTGIHEHFKIENSKNTQDILKEKSDLKTESPTSIPSLNKLISETEHQETINTLFEEKSISEDPHNKELTTNKTISPFKNVENNKFSTLTNLKRKNMPIFSEKTSDSRDAQFSNLNIRSDSQLKKSSTDNSDKHGQKKFIDDYSYRNMNKTENTMISESKNNKSITHEVTNLNILENKNQNLETSTKPKTQKVSDNINLKRLSEYECRQLTTSISISKDQIKEKFLRTFINKTHNSKIEPSDTYTMSQEQSENQLNSTLAKEDFFNMRVIGQFNLGFIITSLPSNEKDYISNIFIIDQHASDERYNFEKLQLNTTMDSQLLIKPYELVLTIIEESIIIEHVEILEKNGFKIEIDYNKDPGKRCKLLSLPQAKHITFGIEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAH1</accession>
    <name>M7PAH1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872900.1">
        <property type="nucleotide sequence ID" value="XM_007874709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PAH1"/>
    <dbReference type="STRING" id="1069680.M7PAH1"/>
    <dbReference type="GeneID" id="19894684"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00986"/>
    <dbReference type="eggNOG" id="ENOG502R79N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_839696_0_0_1"/>
    <dbReference type="OMA" id="VAQWAND"/>
    <dbReference type="OrthoDB" id="4034134at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038872">
        <property type="entry name" value="Put_GTT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807:SF1">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="3"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="331" mass="38282" checksum="C8A1CBAED53CE2A5" modified="2013-05-29" version="1">MALKGMRKSDLQRLASQLNINSDGLKANLETRIVEHLLENKALLSKNPEFSSYYEDSLEDTGSFVNNVKGSSRKKSVVVQKTNVKRPLFATNQSDSFDYKFKNHSEASLLYENNKARHRFNELVNESSDAASESVLSETICISGFNGGCVLKDTFNSCFQYDVLFDKLLNIRKCLSKVLMLDFLFCIYEFYNLLSFLIPWSYKAFLPLFSSFFDYRILYLPDLSVIFSFEKFWSPFLTWWIFTIFIPLIVATIFNFHESRKGEGFKIIDPMTFAVVKTIVVYFIFYKGFQKSFFFANSLSIIKSAIGIDLMFTLSFIGVLYAMYDTLISRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7PB00</accession>
    <name>M7PB00_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Signal recognition particle, SRP19 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00653</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872552.1">
        <property type="nucleotide sequence ID" value="XM_007874361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PB00"/>
    <dbReference type="STRING" id="1069680.M7PB00"/>
    <dbReference type="GeneID" id="19894351"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00653"/>
    <dbReference type="eggNOG" id="KOG3198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065433_1_1_1"/>
    <dbReference type="OMA" id="QDMMQEM"/>
    <dbReference type="OrthoDB" id="2190947at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006617">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.30:FF:000003">
        <property type="entry name" value="Signal recognition particle SEC65 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.30">
        <property type="entry name" value="Signal recognition particle, SRP19-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002778">
        <property type="entry name" value="Signal_recog_particle_SRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036521">
        <property type="entry name" value="SRP19-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01922">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69695">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR11055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="25175" checksum="3B7AE6809BAF69E6" modified="2013-05-29" version="1">MGSNIEDSFQQDSISSTKSQILNEDVSSNKIFYEDTDTSKIIYIENTKEFRRWSILYPLYFDSRRSIKAGRKVPISKAVTNPLANIMANGAKVLGFSCIFEPNKTHPKDWANPGRIRILFKENGIPSHVSLKTKKALYLALSSYLQANPTTKMSPMKVPVSGFNKPPSLPDIPKGILMGDILPLNSPALVSDEFLENFSKDMTKEQKCNINRSKQKKEKKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7PBA5</accession>
    <name>M7PBA5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF866-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_00764</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0587 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872666.1">
        <property type="nucleotide sequence ID" value="XM_007874475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PBA5"/>
    <dbReference type="STRING" id="1069680.M7PBA5"/>
    <dbReference type="GeneID" id="19894462"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00764"/>
    <dbReference type="eggNOG" id="KOG1296">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114688_0_0_1"/>
    <dbReference type="OMA" id="TAHFVWR"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857:SF0">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="CXXC_Zn-b_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141678">
        <property type="entry name" value="MAL13P1.257-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004083040" description="DUF866-domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR11170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="18629" checksum="F953C1E5CAF1FE1A" modified="2013-05-29" version="1">MVALGLFLSAILENITSLEPFDPQNHYYTFKVQCTSCREIHPNLVKISPRETVNIPNSRGKASLVWKCRYCQKENSANIEEKVSQYTFEISPQESHILSFECRGCEFIEFFPDGEWCCKGIKSGTLFRGINLIEGEWYDYDENSLNEVSITNIKWEIKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7PBM9</accession>
    <name>M7PBM9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00295</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872167.1">
        <property type="nucleotide sequence ID" value="XM_007873976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PBM9"/>
    <dbReference type="STRING" id="1069680.M7PBM9"/>
    <dbReference type="GeneID" id="19893993"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00295"/>
    <dbReference type="eggNOG" id="KOG0109">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_556821_0_0_1"/>
    <dbReference type="OrthoDB" id="407442at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="34"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="57177" checksum="CCEB49DB9ED38D39" modified="2013-05-29" version="1">MASASSEAQRTIPNNHQSLPGVVSRPLTEDGRPLKCYIGNLSNQCRMYHLREKFSPFGTIINVELKPNIGCGFVEFVDPESCIKACDALDGTELFGQTLRVETQKQVYGIRKIVTEKLEGCFNCGAKNHWAKHCPKMPPPGTPQNVSPPRSSMLSSEAYGYLKPYSHSVNNYDYPRYYSENLPHYRQPCLNGYRDPYYYAPRDYIFRDRDTRDLRNFQKYRNRGQWNLPSAEKIPENATVSHKRYANSEPWFNESHQLTALPRTSQISTESKFKAEKSLDEDKDAKTQLRNSTHAETMLKTSEKDFISEKKLSNDQNLATCDSPTLAKETQINDSLENKKVIPYRLERKERVSSSYSEPRYNNCYNCQDHIHSESYDRPYLSSKYPNNNPHYDHHVNYTNRHALFRMRSKYPDGYRYCSYSEPYLPYTPYDSNYRSRKSLQHLDYSSNSRMDCAPLNYSQGYLRRCSPLPNLYSPNLYSPTYNYGYSEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7PC16</accession>
    <name>M7PC16_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_03461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875551.1">
        <property type="nucleotide sequence ID" value="XM_007877360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PC16"/>
    <dbReference type="STRING" id="1069680.M7PC16"/>
    <dbReference type="GeneID" id="19897148"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03461"/>
    <dbReference type="eggNOG" id="ENOG502SGD4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_943720_0_0_1"/>
    <dbReference type="OrthoDB" id="2093409at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021036">
        <property type="entry name" value="Ribosomal_mS45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S35, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12298">
        <property type="entry name" value="Bot1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="295" mass="34632" checksum="D97A70D65479B929" modified="2013-05-29" version="1">MILKILRKRQANTMSRLENVSLCILKKIRHFYTEKACNENAKLGSKKENRNLKSNDKKKIQNKKRFSEQSDYIKWLVDPMEGGQYIKPLSKAGTNFIHQKEYPYPLNPKFKPQPPLSLEARRNIGEKWKQGKSLREISDMFGISVIRVEAVLRLLELESKWRQEERTLDSYAQTMHHMLGSATNQSFNEPPFFVFTPSETQNFTLIHENSEFTSKDAADELQRCLYSDFKEKVIQFQSNTFLHNKHDISNKELKLQKEIINSISEKNRFDLKVVDSYTGNIWLLSKGLLKQIKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7PC37</accession>
    <name>M7PC37_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-terminal methionine N(alpha)-acetyltransferase NatE</fullName>
            <ecNumber evidence="5">2.3.1.258</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_00473</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-methionyl-L-alanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-alanyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50564"/>
            <dbReference type="Rhea" id="RHEA-COMP:12726"/>
            <dbReference type="Rhea" id="RHEA-COMP:12727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133398"/>
            <dbReference type="ChEBI" id="CHEBI:133399"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N-terminal L-methionyl-L-leucyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50520"/>
            <dbReference type="Rhea" id="RHEA-COMP:12711"/>
            <dbReference type="Rhea" id="RHEA-COMP:12712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133377"/>
            <dbReference type="ChEBI" id="CHEBI:133378"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-methionyl-L-lysyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50580"/>
            <dbReference type="Rhea" id="RHEA-COMP:12734"/>
            <dbReference type="Rhea" id="RHEA-COMP:12735"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133406"/>
            <dbReference type="ChEBI" id="CHEBI:133407"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-methionyl-L-phenylalanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50528"/>
            <dbReference type="Rhea" id="RHEA-COMP:12715"/>
            <dbReference type="Rhea" id="RHEA-COMP:12716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133382"/>
            <dbReference type="ChEBI" id="CHEBI:133383"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-terminal L-methionyl-L-seryl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50568"/>
            <dbReference type="Rhea" id="RHEA-COMP:12728"/>
            <dbReference type="Rhea" id="RHEA-COMP:12729"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133400"/>
            <dbReference type="ChEBI" id="CHEBI:133401"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N-terminal L-methionyl-L-threonyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50576"/>
            <dbReference type="Rhea" id="RHEA-COMP:12732"/>
            <dbReference type="Rhea" id="RHEA-COMP:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133404"/>
            <dbReference type="ChEBI" id="CHEBI:133405"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-terminal L-methionyl-L-tyrosyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50532"/>
            <dbReference type="Rhea" id="RHEA-COMP:12717"/>
            <dbReference type="Rhea" id="RHEA-COMP:12718"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133384"/>
            <dbReference type="ChEBI" id="CHEBI:133385"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-methionyl-L-valyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50572"/>
            <dbReference type="Rhea" id="RHEA-COMP:12730"/>
            <dbReference type="Rhea" id="RHEA-COMP:12731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133402"/>
            <dbReference type="ChEBI" id="CHEBI:133403"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.258" evidence="5"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872356.1">
        <property type="nucleotide sequence ID" value="XM_007874165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PC37"/>
    <dbReference type="STRING" id="1069680.M7PC37"/>
    <dbReference type="GeneID" id="19894171"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00473"/>
    <dbReference type="eggNOG" id="KOG3138">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_5_3_1"/>
    <dbReference type="OMA" id="ICCRLET"/>
    <dbReference type="OrthoDB" id="47374at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120518">
        <property type="term" value="F:protein N-terminal-methionine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000078">
        <property type="entry name" value="N-alpha-acetyltransferase 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051556">
        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF8">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="14">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR11455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="132" mass="15573" checksum="8D3D6EA55D5997CF" modified="2013-05-29" version="1">MLHQVIFPITYDERFYEESLKMGELVKLAYFNDICVGCIRCQLENKKLYLMTLGVLAAYRGLGIGQKLLNHILEQAKKLNIETIYLHVWTENKEAIEWYTKREFHILETLSNYYTKIHPGTAYVLVRNIVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCB0</accession>
    <name>M7PCB0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Post-GPI attachment to proteins factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_03552</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the lipid remodeling steps of GPI-anchor maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PGAP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875645.1">
        <property type="nucleotide sequence ID" value="XM_007877454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCB0"/>
    <dbReference type="STRING" id="1069680.M7PCB0"/>
    <dbReference type="GeneID" id="19897239"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03552"/>
    <dbReference type="eggNOG" id="KOG2970">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032917_1_1_1"/>
    <dbReference type="OMA" id="DFMIEDC"/>
    <dbReference type="OrthoDB" id="419770at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007217">
        <property type="entry name" value="Per1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148">
        <property type="entry name" value="PER1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148:SF0">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04080">
        <property type="entry name" value="Per1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 7" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016477161" description="Post-GPI attachment to proteins factor 3" evidence="7">
        <location>
            <begin position="20"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="326" mass="38935" checksum="9467105643ED9AD8" modified="2013-05-29" version="1">MVKSLFLLFPFFSIVYVLCSRGNELPEFKNCVSACVALNCREDAPRQFIRGRLSLVLRIGMWDCQSECDYSCQRIVTLYRKKNGLQKEQFWGKWYFIRILAMQEPASVVFSILNGYVHYLGFCWIKLLIPSDYVFKKFYIIYALLGLNTWFWSAVYHIRDFKFTERADYFSAGALTLWSFFFTPLRIFRLDLCRNYNFFVYLWAFTCIFAFLIHVIYLSFVKFNYSYNMAANVLIGFSQNILWVYYSLSNYGTRPFALWPMYIVCAIMIAMCFEIFDFPPILYLFDAHSLWHMATIPIVYYWYKFLILDSNFESKNVKGVQEAIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCE2</accession>
    <name>M7PCE2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinetochore protein mis13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871870.1">
        <property type="nucleotide sequence ID" value="XM_007873679.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCE2"/>
    <dbReference type="STRING" id="1069680.M7PCE2"/>
    <dbReference type="GeneID" id="19893717"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00019"/>
    <dbReference type="eggNOG" id="ENOG502S2VJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052069_0_0_1"/>
    <dbReference type="OMA" id="RIHRYLA"/>
    <dbReference type="OrthoDB" id="3364649at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013218">
        <property type="entry name" value="Dsn1/Mis13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14778">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14778:SF2">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08202">
        <property type="entry name" value="MIS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="39928" checksum="8F47A17FC7BD1D99" modified="2013-05-29" version="1">MPQKGIFNAAGPCKALQDVRCLKTTIHEEDSGFQFVRTRKPEMQESYGDTSTHSSMHMMDSFIKLPTCDTPVIEKNRDLRQRRRSSLGLRGKRASSIIANGSIALPHPSISHESFFKHISEDLPEPVRMKQLLIWCAKRALDEQKMSGLGKDSRAASLARTIEEEILSDLIENKLSPSWYNRKEEDILIKPKPHPRNIENQKKIKEFEEKLSRLKEEINTWNRLETSFLSCKNNRDFENPQDIVSETAANGVLFPSEDIKLDCPIDHSELLEWLKSEKANLEFKVDRLYHSLHVIDSFTQVSNRYATQLLSNVAKAIQEREKQAQVNSGTSDINIKDVLREITRRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCI8</accession>
    <name>M7PCI8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Endonuclease III homolog</fullName>
            <ecNumber evidence="13">3.2.2.-</ecNumber>
            <ecNumber evidence="13">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="13">DNA glycosylase/AP lyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">NTH1</name>
        <name evidence="15" type="ORF">PNEG_00059</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="13"/>
    <dbReference type="EC" id="4.2.99.18" evidence="13"/>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871915.1">
        <property type="nucleotide sequence ID" value="XM_007873724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCI8"/>
    <dbReference type="STRING" id="1069680.M7PCI8"/>
    <dbReference type="GeneID" id="19893757"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00059"/>
    <dbReference type="eggNOG" id="KOG1921">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_4_3_1"/>
    <dbReference type="OMA" id="QIIWYGR"/>
    <dbReference type="OrthoDB" id="2099276at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034042">
        <property type="term" value="F:5-formyluracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034043">
        <property type="term" value="F:5-hydroxymethyluracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000003">
        <property type="entry name" value="Endonuclease III homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000005">
        <property type="entry name" value="Endonuclease III-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03183">
        <property type="entry name" value="Endonuclease_III_Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030841">
        <property type="entry name" value="NTH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286:SF1">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HhH-GPD" evidence="14">
        <location>
            <begin position="118"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR11620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="333" mass="37950" checksum="855C94D38A9F6C3C" modified="2013-05-29" version="1">MTQRSYCASKNTTKKTVINFLRKNTRNRFPNGIQKMKEQGRSDAVKKLETDILLHSRIDYNENTSESSPKYWKVVYNEIKKMRETIASNAPVDTMGCDVAADKDVDTSRLQTLISLMLSSQTKDTANYIAMKTLKQKLPGGLTLKSLIEVDENLLNDYIRPVGFHNRKTKYIKETVKILEKDYNGDIPSTIEDLVALPGVGLKMAHLCLSSAWNKTEGIGVDVHVHRISNLLGWVNTKTPEQTRLKLESWLPKKYWKEINHLFVGFGQTICLPRGRKCSQCTLSSQNLCPSSIKEKNILSKNLYEKDTENMNNTSNLENIINKYKIIDVEDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCS2</accession>
    <name>M7PCS2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Dihydroorotate dehydrogenase (quinone), mitochondrial</fullName>
            <shortName evidence="11">DHOdehase</shortName>
            <ecNumber evidence="4 11">1.3.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_00139</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>(S)-dihydroorotate + a quinone = orotate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="11">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="4 11"/>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872000.1">
        <property type="nucleotide sequence ID" value="XM_007873809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCS2"/>
    <dbReference type="STRING" id="1069680.M7PCS2"/>
    <dbReference type="GeneID" id="19893837"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00139"/>
    <dbReference type="eggNOG" id="KOG1436">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013640_4_0_1"/>
    <dbReference type="OMA" id="VYCYSAL"/>
    <dbReference type="OrthoDB" id="14784at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106430">
        <property type="term" value="F:dihydroorotate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050074">
        <property type="entry name" value="DHO_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01036">
        <property type="entry name" value="pyrD_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109:SF4">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11" id="KW-0288">FMN</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="12">
        <location>
            <begin position="91"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR11705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="409" mass="45312" checksum="FBC8F0B902F621C4" modified="2013-05-29" version="1">MIKTGFFAFSPSFKYYPFFFALKRVTTGVFAASFSGLFLYYYTDSRAAIHTYGTCLLLRTIVPPELAHNFAIKAIRWGLAPWDKKIDDSSLMLNVWGKVISNPVGLAAGVDKQAEAIDGLFDLGFGYVEVGSVTPCAQPGNPPPRFFRLKKDASVINRYGFNSDGHDVIARRLHDRISKYVFKNYPDLGQIPHFLVQSARNIELVNFLNIPKSLRKNKLLAVNLGRNKNSDGIDDYVKGVRRLGQYADVLVINISSPNTFGLRLLQQKKYLETLLSAVVQERDLLPDPKPALCIKISPDLKDLELQDIVDVILKIPIDGVVVSNTTIQRPKNLKEDKFLHEQGGLSGPPLKLLALDIIRFLRGKLPENCLIIGCGGISSGKDAIEYARAGASLTQCCTAFGKVAIVHNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCU4</accession>
    <name>M7PCU4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA ligase</fullName>
            <ecNumber evidence="1">6.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_03426</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + (ribonucleotide)n-3'-hydroxyl + 5'-phospho-(ribonucleotide)m = (ribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.3" evidence="1"/>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875512.1">
        <property type="nucleotide sequence ID" value="XM_007877321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCU4"/>
    <dbReference type="STRING" id="1069680.M7PCU4"/>
    <dbReference type="GeneID" id="19897113"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03426"/>
    <dbReference type="eggNOG" id="ENOG502QQB9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010316_1_0_1"/>
    <dbReference type="OMA" id="FQDWDYK"/>
    <dbReference type="OrthoDB" id="276239at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051730">
        <property type="term" value="F:GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032056">
        <property type="term" value="P:positive regulation of translation in response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000622">
        <property type="term" value="P:regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019039">
        <property type="entry name" value="T4-Rnl1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012387">
        <property type="entry name" value="Trl1_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015966">
        <property type="entry name" value="tRNA_lig_kin_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015965">
        <property type="entry name" value="tRNA_lig_PDEase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004:SF1">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09511">
        <property type="entry name" value="RNA_lig_T4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08302">
        <property type="entry name" value="tRNA_lig_CPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08303">
        <property type="entry name" value="tRNA_lig_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019634">
        <property type="entry name" value="tRNA_lig_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="T4 RNA ligase 1-like N-terminal" evidence="5">
        <location>
            <begin position="68"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase kinase" evidence="4">
        <location>
            <begin position="388"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase phosphodiesterase" evidence="3">
        <location>
            <begin position="562"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="2">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR019634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR019634-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="788" mass="90971" checksum="603F0388F5E036F4" modified="2013-05-29" version="1">MSGSVKKENQETAHELISRIEKEVKKNENKKSKSISKHTFIYGDGVKIDSWKLPNFGFKKSSKLVTDIRGLFSITNDKNIHEIVIRGYNKFFAVNEVKETKWDSLEKHTIGPYALTLKENGCVIFVSALSDDSLIVASKNSMGPVANGTSVHAQVGETWLERHLSDSMHTRKQLARVLRQMNATLVFELCDDGFEEHIIEYPPEKRGLYLHGINLNEATFVTYEFDKVCLFAHNWGFRQVDYKIFQTLSELKYFLEDSEKTKSYYGREIEGFVIRCKSKLLDDIHFHDFFFKYKFKEPYFIYRRWRELTHAIISGTYKFNSNEDDITKKYVIWVRLLLKENPDFVEKYKQNHGIVALRKQFLKEYNYSPSDFSKKLVINCPLEDRNILLVPIATIGCGKTTLAFALSLLFGFKHIQNDDIPGKKAKIQKFVSAIVDALKHQHVVVADKNNHKYSERDELIRLVSERSPNTRFIALYYDHFDKNDDLVTRKEKLNEILKVTKARVLARGSNHQTIDASLNQGKTAIGIMNGFLSRFEPLDLNKEPDNLFEDSIILDPMKDTKFNLENVIKRLHEIAPKFVIKIPTASEIDSAIRIALNHFCPNKRSGLTLSHQKTGLLSQQKSQYFGIILKDDLAPYIEQIMKDQKKEVSAFWEHLKRSKRVQSTFHVTLIHISDKSKYPEIWQYYLSQMDSSGVVCSAQVEFTYLVWDSRIMALVAVILDMENKKIQSANPILHATIGTENKTIHPKEANDMLALWNFQTSHSNIHTLSLSPKHFDGTVALVDSFSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7PDF3</accession>
    <name>M7PDF3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_03315</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875391.1">
        <property type="nucleotide sequence ID" value="XM_007877200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PDF3"/>
    <dbReference type="STRING" id="1069680.M7PDF3"/>
    <dbReference type="GeneID" id="19897002"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03315"/>
    <dbReference type="eggNOG" id="KOG3405">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112527_0_2_1"/>
    <dbReference type="OMA" id="MTYNDEP"/>
    <dbReference type="OrthoDB" id="259769at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.10:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00192">
        <property type="entry name" value="RNApol_arch_Rpo6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028363">
        <property type="entry name" value="RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002208">
        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500154">
        <property type="entry name" value="RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="159" mass="17780" checksum="2E1144A873CA98B9" modified="2013-05-29" version="1">MSDYGGDDGNRYDFDEPTLDDDDFLPLPEEGIDENLDEINEEEIGGSRGLNGLGQDVDMMESNESKARFSGSRGKGKAVLPENRVTTPYMTKYEKARILGTRSLQISMNAPVLVDLEGETDPLQIAMKELSQKKIPLLVRRYLPDGSYEDWAVSELITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7PDQ2</accession>
    <name>M7PDQ2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor 1-gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_03075</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875131.1">
        <property type="nucleotide sequence ID" value="XM_007876940.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PDQ2"/>
    <dbReference type="STRING" id="1069680.M7PDQ2"/>
    <dbReference type="GeneID" id="19896762"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03075"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_3_0_1"/>
    <dbReference type="OMA" id="TQYFSWT"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03181">
        <property type="entry name" value="GST_C_EF1Bgamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03044">
        <property type="entry name" value="GST_N_EF1Bgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000006">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000142">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1010:FF:000001">
        <property type="entry name" value="Elongation factor 1-gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1010">
        <property type="entry name" value="Translation elongation factor EF1B, gamma chain, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001662">
        <property type="entry name" value="EF1B_G_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036433">
        <property type="entry name" value="EF1B_G_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00647">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01183">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89942">
        <property type="entry name" value="eEF1-gamma domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50040">
        <property type="entry name" value="EF1G_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="87"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="EF-1-gamma C-terminal" evidence="4">
        <location>
            <begin position="241"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="46040" checksum="CA5113A4B84DBC0E" modified="2013-05-29" version="1">MSFGKLYGYAENSRTIALLILAKENNLDVELVVENPNVGLSKEYLEHFPKGKIPGFLGSDGFCLTETNAIAIYFASQNEKTTLLGKTKQEYTSILQWMSFANTDLIRSIALWFFPLVGRMPYSKKVVDENQAETNRLCRYVDDFLKLRTFFVGERLTLADLVMAAHITPGFLTVFGADWRRGFPNLVRWYLTVVNQPIWTAASPIPVMIEEPVKYVPKKSEKETIPPKSDAELEKPLVEKPKHLLDSSPSSSFVLDEWKRQFSNNDLETAMKWFWEHLDIEAYSLWRLDYKYNDELGLIFQSSNLCGGFFQRLDASRKHIFGSLVVYGKDRDNIISGVFLVRGKDFKTAFDVAPDWESYNFICLDPTKEEDKKHIKSVWGRNDPIEVDGKIYPAADGKIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7PEI2</accession>
    <name>M7PEI2_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">60S ribosomal protein L11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02659</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes). Component of a hexameric 5S RNP precursor complex; this complex acts as a precursor for ribosome assembly. rpl11a/rpl11b/uL5 forms a heterotrimeric complex with rpl5a/rpl5b/uL18 and syo1. Interaction of this complex with KAP104 allows the nuclear import of the heterotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874680.1">
        <property type="nucleotide sequence ID" value="XM_007876489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PEI2"/>
    <dbReference type="STRING" id="1069680.M7PEI2"/>
    <dbReference type="GeneID" id="19896350"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02659"/>
    <dbReference type="eggNOG" id="KOG0397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061015_3_0_1"/>
    <dbReference type="OMA" id="MDFYCIM"/>
    <dbReference type="OrthoDB" id="1734943at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_uL5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057266">
        <property type="entry name" value="Ribosomal_uL5_euk/arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003258">
        <property type="entry name" value="PRK04219.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="7">
        <location>
            <begin position="8"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="8">
        <location>
            <begin position="65"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00064641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="175" mass="20086" checksum="D37A8A9B2593D558" modified="2013-05-29" version="1">MEIEKGSNPMREIKIQKLVLNISVGESGDRLTRAAKVLEQLSGQTPVYSKARYTIRAFGIRRNEKISVYVTVRGAKAEEILERGLKVKEYELKRSNFSDTGNFGFGIHEHIDLNIKYDPSIGIFGMNFYVVLGRPGFRVSKRRRCRSSVGSNHKVTKEDAIRWFKNRYDATVLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M7PER6</accession>
    <name>M7PER6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_02738</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874765.1">
        <property type="nucleotide sequence ID" value="XM_007876574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PER6"/>
    <dbReference type="STRING" id="1069680.M7PER6"/>
    <dbReference type="GeneID" id="19896429"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02738"/>
    <dbReference type="eggNOG" id="KOG0859">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064620_1_1_1"/>
    <dbReference type="OMA" id="NTKLMIM"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15843">
        <property type="entry name" value="R-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF168">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="7"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="135"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR08959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="228" mass="26419" checksum="ACFD1BA7DA61EBD6" modified="2013-05-29" version="1">MSIFYVGIARGRDILAEYTVDGIEIKHLVSLVLEKIESNEETRLTYLYKSYMIHYICTPVVPVGSLTYLCITSDQIGRRVPFALLAEIKHEFGSRFSLCDIFELPTSSFSFFSHEISKKIDTIMNSEDGMIMVDMARVVHKEIEQVKSAMMENIERVLERGERIELLVDRTQNMNETAFTFSKRSTYLRRRILWESIKTTVILSLVVLFLLYLLIGFGCGFPVWQNCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7PFB6</accession>
    <name>M7PFB6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA replication regulator Sld3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874506.1">
        <property type="nucleotide sequence ID" value="XM_007876315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PFB6"/>
    <dbReference type="STRING" id="1069680.M7PFB6"/>
    <dbReference type="GeneID" id="19896188"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02495"/>
    <dbReference type="eggNOG" id="ENOG502S01X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_454243_0_0_1"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013948">
        <property type="entry name" value="DNA_replication_reg_Sld3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042511">
        <property type="entry name" value="Sld3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28067">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28067:SF1">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08639">
        <property type="entry name" value="Sld3_STD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication regulator Sld3 C-terminal" evidence="1">
        <location>
            <begin position="160"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="601" mass="69530" checksum="872E03829BAAA968" modified="2013-05-29" version="1">MKRHERKTIFPQKPSYIVSDFVIHPEGVDALHASILYQASRNTIPRHWIAHENIPLVFQCRMLEILLNNDNVLVVEAKKDVEPVYGVIECMKHRIYVFSEFDSRVTRIEVLKLHGRCEISENIEKTADIETPLLQVVLPWQPLVINSIKDSDMKQISSKEILNSLRQQYFYILYISKVSLAYFAKTTLAKARKECQEVYLHENKGYFEMMKFIETEMLRTPEELEMKFKKWLPLLVEVTLDETNDVNINEWPEEVKCWPVDADEREFILKWCNCNEDCVFRNKKNVNKRIDALKFREFELQIILVLEVLLLCYETKNYVSDQELKKSHMSINVEQYLDILVDRLCIWQALNDTDLSFDKNIDQKTNSDQLLQFCAEVVMPFYASKLPDICSGLFVKCGGPILCHHSLRSKSDKKKIQKANPSAFSKPLVTAIKSLSNVSTKSPVDITSSLATALGDEKAKLQSVSVTPRPSMDSRVKGISRDGILNSKKSLQHREIKMPLSKITKKEKLDDLTSLSNQQFVRPRVETQRIQMKQKSVTGQIQVLATPQKNRMARQTTNSMGDLAEWNEGWVMNTSINVDVNRTPLKKRQKVDVISETPIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7PFH3</accession>
    <name>M7PFH3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translationally-controlled tumor protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCTP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874558.1">
        <property type="nucleotide sequence ID" value="XM_007876367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PFH3"/>
    <dbReference type="STRING" id="1069680.M7PFH3"/>
    <dbReference type="GeneID" id="19896237"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02545"/>
    <dbReference type="eggNOG" id="KOG1727">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095877_0_0_1"/>
    <dbReference type="OMA" id="AYNKCIK"/>
    <dbReference type="OrthoDB" id="10248936at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007026">
        <property type="term" value="P:negative regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.10:FF:000002">
        <property type="entry name" value="Translationally-controlled tumor protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018103">
        <property type="entry name" value="Translation_control_tumour_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
        <property type="entry name" value="TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
        <property type="entry name" value="TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00838">
        <property type="entry name" value="TCTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01653">
        <property type="entry name" value="TCTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01003">
        <property type="entry name" value="TCTP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TCTP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR09209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="167" mass="19228" checksum="4FC34E5D02974180" modified="2013-05-29" version="1">MLLYRDIISGDELISDAYNLKEVDDVVYEVDCAMVQIKQGEVDIGANPSAEGDEEVAEDGVEIVNNVVYSFRLVSTTYTKKDYQVYIKSYLKKLKQYLQENRPDRVEVFEKGVTTFIKKVLANFSDYDFFIGESMDVDGMVVLLNYREDGITPYMTFFKDGLKEEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7PGT3</accession>
    <name>M7PGT3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription regulator Rua1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873830.1">
        <property type="nucleotide sequence ID" value="XM_007875639.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PGT3"/>
    <dbReference type="STRING" id="1069680.M7PGT3"/>
    <dbReference type="GeneID" id="19895553"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01859"/>
    <dbReference type="eggNOG" id="ENOG502S1PM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_484936_0_0_1"/>
    <dbReference type="OrthoDB" id="5595379at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028012">
        <property type="entry name" value="Rua1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28125">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28125:SF2">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14616">
        <property type="entry name" value="Rua1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator Rua1 C-terminal" evidence="2">
        <location>
            <begin position="412"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="562" mass="63875" checksum="C301837FCE7BDF57" modified="2013-05-29" version="1">MKSEKDLSYAFRRNACDMFLTSTVNMFSSAYIPEKARASIAVWQDDIVDGGIVDIKCIENIQSISSHSFNGNIVNLNESSVSEELSVLESSTRVDNFSIHEEELSSVLEVGEEGDWLDKVWVDENRRRVISSSINGRRPLAALSTNTLALKKKEIYSSIALCESALQYDPVYTCNSSATIFSITPSLTEFCHSTPTDHKTTILSVDNSLNDEFSNTHMNSSTIEENTIQKRKDTLALSSFVLAQFRTKRISTLRATTLGKRVGQELTKLSKNVSCKRLFPNNKRTIVAGRQFRRVRQKATEDEVEDLLLKSEFSHSHIQNIYSTQKFTRPSYIYSKRIDFLDNNIALKSESSSDSSHSSNFYSPLSSRPSLPLSTQRTFPENIPIHPDFFRYYLAHPRFTYSNGNPPIQYDVDDLYNPRYIKGIGINKMGMCPICCENIERGGQGKEVWLKMKISAFWYHMNFFHGINPTTALPYSPPVSFRTVPLVTMNANGISKKKKASGFTSIPDRKEILEGKCHKCKKWVRVQGIKEQEVKVAEIFWWKHARSCHGTSRIKGEGCEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7PHX7</accession>
    <name>M7PHX7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01819</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873791.1">
        <property type="nucleotide sequence ID" value="XM_007875600.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PHX7"/>
    <dbReference type="STRING" id="1069680.M7PHX7"/>
    <dbReference type="GeneID" id="19895513"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01819"/>
    <dbReference type="eggNOG" id="KOG0835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022000_3_2_1"/>
    <dbReference type="OMA" id="WEDVWSV"/>
    <dbReference type="OrthoDB" id="10264655at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20532">
        <property type="entry name" value="CYCLIN_CCNL_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20533">
        <property type="entry name" value="CYCLIN_CCNL_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036580">
        <property type="entry name" value="Cyclin_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="37"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="267" mass="31282" checksum="1FA3976D7E78ECFA" modified="2013-05-29" version="1">MRRNNAQIDVNQAKETPSRRSGISKDLEGEMRNAGAELIRQASILLELHITCFGTAEVLFQRFYYSESLRKFSIKEIAMGAIFTASKITEYPIKIKDIIRIFSRLFDCREGKPMKVLEYFEEFFYRTRDQILIAEITILSSLGFDTFVELPYRLAIHYLQILDLINHEIILQKVWSCINDALCTRVSCIQSAPSIAIGCIFIATREEKIKLPYAWWEIFDVFLEDVKYIAASIKSFYIEEEERKRREREGNLTPIDLEELEKYLSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7PIB7</accession>
    <name>M7PIB7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ceramide glucosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.80</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glucosylceramide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">UDP-glucose ceramide glucosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">UDP-glucose:N-acylsphingosine D-glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PNEG_01477</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">B123</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.80" evidence="5"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873416.1">
        <property type="nucleotide sequence ID" value="XM_007875225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PIB7"/>
    <dbReference type="STRING" id="1069680.M7PIB7"/>
    <dbReference type="GeneID" id="19895173"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01477"/>
    <dbReference type="eggNOG" id="KOG2547">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030898_1_0_1"/>
    <dbReference type="OMA" id="HELRWNR"/>
    <dbReference type="OrthoDB" id="1483400at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008120">
        <property type="term" value="F:ceramide glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006679">
        <property type="term" value="P:glucosylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02520">
        <property type="entry name" value="Glucosylceramide_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726:SF0">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13506">
        <property type="entry name" value="Glyco_transf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMR10204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="410" mass="47562" checksum="245F2EAD5512E9CF" modified="2013-05-29" version="1">MVFLEIFAWTVLTWYVFVISLIILGWVTIRSIDSESMIHNEETLTETLPGVSILRPLKGLDPHLYDCLESTFVQKYPKFEIILSVADETDPAVSVAKEIIVKYSNVDARIIIGDERIGQNPKINNLVRSEREAKYDILWILDSNIWISQGCIERSVKSLMTPGVQLVHHLPVCIASSSRPSVGSCLDEMFLSTFHARMYSAINRIAVTPCVIGKSNLFRRISLLSRAPKGLKEFSNYIAEDHLIATTLWTRRKSHFMASEYVWQPVENIRVSDYIARRIRWIRLRKYVVTVPTLVEPFTESILSGFLGAWSISILSNFRHVYILWIIHMFIWMVMDYTQFNILRSSLPTEIKNDSNLTPCCYNFFHWICIWVLREILAFPIWVIGISGSRIYWRNQTFTLRSDMTAQTVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7PIK4</accession>
    <name>M7PIK4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone-binding protein RBBP4-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_01529</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873474.1">
        <property type="nucleotide sequence ID" value="XM_007875283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PIK4"/>
    <dbReference type="STRING" id="1069680.M7PIK4"/>
    <dbReference type="GeneID" id="19895224"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01529"/>
    <dbReference type="eggNOG" id="KOG0264">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020445_3_1_1"/>
    <dbReference type="OMA" id="PHEEGCL"/>
    <dbReference type="OrthoDB" id="427795at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000512">
        <property type="entry name" value="WD-40 repeat-containing protein MSI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="9">
        <location>
            <begin position="38"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="277"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="321"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="378"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR10264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="430" mass="48605" checksum="E024069A41A8CCCC" modified="2013-05-29" version="1">MQKRNESDGNFQQDTTMTMNADEREAEEQIVAEKLINEEYKIWKKNSPFLYDLIVTHALEWPTLTIQWFPDKETVPGKSYSVHRLLIGTHTSGNDQNYLKFAEVHLPLSSTDIDIRKYDEEKEEIGGYEGTDAKINIVQKIDHEGEVNCARYQPQNPNIIATMTVSGEVYIFDRTKHSSNPMGTCNPQIKLKGHTKEGYGLSWNPHKLGYLVTGTEDTTIWSNILSPIHIYTTHTAVVTDVAFHPLHDSLFGSVSDDLYLQIHDIRSSNITSAAHKVNAHSEAINSLAFNPACEYVLSTASADKTVALWDLRNLKLKLHSFEGHDDEVTSLSWSPHEETILASSSIDRRIILWDLSKIGEEQSPEDAEDGPPELLFMHGGHTNRVSDFSWNLNDPWVLASSAEDNIVMVWQPANNIYKKDDIDVPSSDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7PIS8</accession>
    <name>M7PIS8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Las1p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873564.1">
        <property type="nucleotide sequence ID" value="XM_007875373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PIS8"/>
    <dbReference type="STRING" id="1069680.M7PIS8"/>
    <dbReference type="GeneID" id="19895302"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01607"/>
    <dbReference type="eggNOG" id="KOG2425">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_581602_0_0_1"/>
    <dbReference type="OrthoDB" id="10263222at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002:SF0">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="50787" checksum="4C425CFEDB8A1081" modified="2013-05-29" version="1">MNLSFRIVPWRSRSEFNQVRDWFYGTDRNQESLMKGLSRVNAWQVRGRLPHAVESTANLVCVLVEEERGICNPLGLRLSYAMALIRFVNGFLDPEQQGQYIIPMQTLARNINLPLSFVEIRHAATHEQLPSLVVLRSMTIRALEWLLDKYWSRSYEDIEGMDEKKIQDIIKKWEIFQEKNLDKGSKSKDSAKEMSIIIKESIILCNSSNGVEIITNYLLEKIMALPKNMKKEDFFNRSYAIWLPFIKKVSFISDLVQHFALKIISKLGSNDPKNNYMIDPLPIFSLSALKGSLKNDINDVCHILLLWLQNLLNEKYQGDISAKSLFPQLSIHKIIHACLLQTDSYTAQFLKNIVLSDQHLLKSYHTLISLRLNIATFPQKKHTLDDIEIEVNAFKKRFYTLTRKVDDSNSIEKKPLILANGRWKKWHGKWVSKPIGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJ21</accession>
    <name>M7PJ21_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01163</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873078.1">
        <property type="nucleotide sequence ID" value="XM_007874887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJ21"/>
    <dbReference type="STRING" id="1069680.M7PJ21"/>
    <dbReference type="GeneID" id="19894860"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01163"/>
    <dbReference type="eggNOG" id="KOG3146">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1195299_0_0_1"/>
    <dbReference type="OrthoDB" id="302705at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03382">
        <property type="entry name" value="PAP2_dolichyldiphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039667">
        <property type="entry name" value="Dolichyldiphosphatase_PAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF59">
        <property type="entry name" value="DOLICHYLDIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="63"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="232" mass="26983" checksum="43A462CD30E3B092" modified="2013-05-29" version="1">MPIIMQSIYSKQSELYNVSSFQTTYIYNPRDFLSTISALLALLPLEVVVVYLTLIYCRREVEVILIYIGQIICQLLNVHLKEKIQQPRPNPLIKGYGMPSNHAQFTSYFTGYMILWMFFRARYLPKIYYTRNTIVLAFLLISICFSRVYFKYHTIWQVIVGVLVGTAFSTICELAASFKAKCIFLHQRHDERGTPINRKRMAGLEAKTSNTAEESNARTVIILNRPHQSYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJU1</accession>
    <name>M7PJU1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872779.1">
        <property type="nucleotide sequence ID" value="XM_007874588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJU1"/>
    <dbReference type="STRING" id="1069680.M7PJU1"/>
    <dbReference type="GeneID" id="19894567"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00869"/>
    <dbReference type="eggNOG" id="KOG2606">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034963_1_1_1"/>
    <dbReference type="OMA" id="YELGAHY"/>
    <dbReference type="OrthoDB" id="415023at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22762">
        <property type="entry name" value="OTU_fungi_OTU2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049771">
        <property type="entry name" value="OTU2-like_OTU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF10">
        <property type="entry name" value="DEUBIQUITINASE OTUD6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="1">
        <location>
            <begin position="52"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="198" mass="23255" checksum="8A9D50AE41B06502" modified="2013-05-29" version="1">MSRKNRQKIRQEKKKKEIERIKNEASFDEESSVDMRKFEKDIISSIIEKMSFEEKDIVPDGHCLYRAFSDQLAVRHDIHIDYLQLRTVAASYIREHEQSFIPFLFNDETGEIRDVESYCNDIEHTAIWGGEVEIIALARAYKVNVELIQMKGLPLKINFDPDGETSFSQNKNTIKLSYYQHMYALGAHYNSLRDKVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7PKM3</accession>
    <name>M7PKM3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00610</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872507.1">
        <property type="nucleotide sequence ID" value="XM_007874316.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PKM3"/>
    <dbReference type="STRING" id="1069680.M7PKM3"/>
    <dbReference type="GeneID" id="19894308"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00610"/>
    <dbReference type="eggNOG" id="KOG1781">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PFVQQEE"/>
    <dbReference type="OrthoDB" id="274944at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01729">
        <property type="entry name" value="LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000043">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017132">
        <property type="entry name" value="Lsm7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037188">
        <property type="entry name" value="U6_snRNA_Lsm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="9">
        <location>
            <begin position="30"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="121" mass="13811" checksum="2AE8A1ED938B479E" modified="2013-05-29" version="1">MDRNYDFTKNNDYGIRGRSYMSTADKPKKEAILDLGKYQDQKVRVKFMGGREIVGILKGYDPLMNLVLDEVIENLRDEDGNITDQKRQLGLVVIRGTTLVLFSPVDGSEEIKNPFLEQVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M7PKS3</accession>
    <name>M7PKS3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PNEG_00661</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872561.1">
        <property type="nucleotide sequence ID" value="XM_007874370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PKS3"/>
    <dbReference type="STRING" id="1069680.M7PKS3"/>
    <dbReference type="GeneID" id="19894359"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00661"/>
    <dbReference type="eggNOG" id="KOG0924">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_6_1_1"/>
    <dbReference type="OMA" id="VDVMFHR"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000615">
        <property type="entry name" value="pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000018">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase prp16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF91">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="558"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="743"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1226"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="487"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMR11064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1246" mass="142124" checksum="193EABD05DA33AC9" modified="2013-05-29" version="1">MKSFSGFGDEFIHTIAIRLSRYLNLMNPNEVLAKKVVSLAVEMADICSFAEAIRTFGRFSDEVAETLWKDIREEKSKLLEEEVPECLTVFSSEVDQLPGSLNPEIGGLLPMNSGPANMGGPKIVQRPSLLGLDKLSQKKREHVGLKMEKDMKRLCSDINDKHLESPNIEFKAPLSKKVDGSFSSRNNARIRRIDTPSYGSGLSEVSKENLRLYRSRHDNMKGLFEKKKDMEYGRSNNHNSRFNENNYSFFDRNVSITKSFSNDPEMLYKMGDLEHIERNTDLPINTNGMDKMKYLNTPRVTGSVWNNQESTSQENIKNDYDLVEWENNEAKLDRDWYNADEFGNVYGDDTHNPFFQFEDQERNQNEMLFKKKTKRISAKQREFNRENDHWEMNRMLVSGVAQRSFVDMDFEDENENRVHLLVHDLKPLFLDGRQVFSKQDSVSAVKDPQSDMAVFARKGSLLVRERRELSERMKASAEVANLAGTTLGNLMNIRDEVKDKIEKAKSKQKLGEDEDIKESNKFSTYMKKSEAASEFSRGKSLTEQREYLPAFAVREELLNVIRENRVTIVIGETGSGKTTQLTQFLHEDGYSNYGLIGCTQPRRVAAMSVAKRVSEEMMVKLGTVVGYAIRFEDCTSSDTVIKYMTDGVLLRESLVDPDLGKYSCIIMDEAHERSLNTDILLGLIKNILTRRKDLKLIVTSATLNAERFSRFFGNAPQFNIPGRTFPVDILFSKSPCEDYVDSAVKQVLTIHLSHPSGDILVFMTGQEDIEITCQVIAERLEQLDNPPKLLILPIYSQMPADLQAKIFERAENGARKVIVATNIAETSLTLDGIMYVVDSGYCKLKVYNPRMGMDALQITPISQANSNQRSGRAGRTGAGIAYRLYTESAFQNELYIQTIPEIQRTNLANTILLLKSLGVKDLLNFDFMDPPPEDTIMSSLFDLWTLGAVDNIGNLTPLGQRMSSFPMDPPLSKLIIASEDYGCTEEMLTIVSMLSVPSVFYRPKERQEESDAAREKFFVPESDHLTLLHVYSQWKSNGYRDEWCTKHFLHPKVMRRAREIRQQLVDIMKFRKMKSISCGSDWDVIRKCICSGYFHHAAKVKGIGEYVHIRSGMPCHLHPTSSLYGLGYLPDYVIYHELILTSKEYMSIVTSVDPYWLAELGGMFYSVKEKGFSISKKATERIISRKLEYEAEIQAERERQIQLEEERQKEVLRTKKSAIAAARIATPGLNRKGLKGSETPRRSRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7PKY1</accession>
    <name>M7PKY1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00725</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in vesicular protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the VPS35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872626.1">
        <property type="nucleotide sequence ID" value="XM_007874435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PKY1"/>
    <dbReference type="STRING" id="1069680.M7PKY1"/>
    <dbReference type="GeneID" id="19894423"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00725"/>
    <dbReference type="eggNOG" id="KOG1107">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005836_0_0_1"/>
    <dbReference type="OMA" id="YIRSREY"/>
    <dbReference type="OrthoDB" id="10258141at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030906">
        <property type="term" value="C:retromer, cargo-selective complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.660:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.660">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35, helical subcomplex Vps35-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005378">
        <property type="entry name" value="Vps35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042491">
        <property type="entry name" value="Vps35_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03635">
        <property type="entry name" value="Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009375">
        <property type="entry name" value="Retromer_Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="891" mass="102824" checksum="BDA81847507460E0" modified="2013-05-29" version="1">MSTVSGSTTLQENQGKPLDELLASIRTYTHQMRRCLDSNRLMDGLKHASTILSELRSDHLGPKQYYELYMAVFDALRYLSIYLLEAHQAGRHHLTDVYELVQYAGNIVPRLYLMITVGTVYMGIKDAPVKEIMKDMMEMSRGVQHPIRGLFLRHYLSGQTRDHLPVGASTGPEGNLNDSISFILTNFIEMNKLWVRFQHQGHSRERAKREEERTELKILVGTNLVRLSQLEGIDLHIYKTNILPSIMEQIIQCRDVLAQEYLMEVIIQVFTDDFHLQTLDQFLSVTMKLNPHVNIKQIWIYFIDRLTAYVSKEAEVESFDERVKKEKLALEALGDQLSSMNLNEEILDVSAENNCSNDIKEQDYDITNGTIKTEIDDKSSVVPNDVKLFDLFWLQIIKLVKVRPDLPIQDITALLVSLCNLALTCYPYEFHYIDQVLKYARLKMMEYVDSIDLHSPESRDNFLKLLLAPISSYSYILTVLFLPNYIPLLQTQLYHTRKVVAATVIQSLIKSKICIDTPSILEGVISLVRVLITEGMKLSPVGNVQQNRRTKDNETDETLEEQGWLARLVHLVYNENADIQFKLLQILRKNFFEGAERIKYTSPPLITQAIKLARKYKSQENLDNDWNQKASSVYKFIHQIISNLYTKVTNAELCIRYFVIAGQVADQGAFEEIAYDFFAQAFTIYEESLSESRAQYQAVVIIAGVLQMTRNFSSENYDTLITKCALHGSKLLKKPDQTRAVYFASHLWWVTNIPAKGEHDDKNLYHDGSRSLECLQKALKLADACIDPLTSTELFVEILNRYIYYYDHQNESILPKFLNSLIDLIKQNIDNFDALTFEPNSRQFPVVTSTSSILEPEGNMQDYVIKYFKRTLAYIEMRKKQEPSLWSVIHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7PMN8</accession>
    <name>M7PMN8_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">40S ribosomal protein S13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00163</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872024.1">
        <property type="nucleotide sequence ID" value="XM_007873833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PMN8"/>
    <dbReference type="STRING" id="1069680.M7PMN8"/>
    <dbReference type="GeneID" id="19893861"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00163"/>
    <dbReference type="eggNOG" id="KOG0400">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090139_1_0_1"/>
    <dbReference type="OMA" id="MHTRRKG"/>
    <dbReference type="OrthoDB" id="623277at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000003">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.130:FF:000001">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_uS15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_uS15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006331">
        <property type="entry name" value="PRK08561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15P/S13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF6">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="151" mass="17163" checksum="C604A832010E7C48" modified="2013-05-29" version="1">MGRMHTPGKGISSSALPYSRAPPSWCKVESEEVCELIFKYAKKGLSPSQIGVVLRDSHGIPQIRFITGNKILRILKSNGLAPQIPEDLYHLIKKAVTVRKHLERNRKDKDSKFRLILIESRIHRLARYYKRIGSLPPVWKYESATASTLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZX01</accession>
    <name>A0A0W4ZX01_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_04295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ATPase epsilon family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="KTW32891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613365.1">
        <property type="nucleotide sequence ID" value="XM_019757814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZX01"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZX01"/>
    <dbReference type="GeneID" id="30671581"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04295"/>
    <dbReference type="OrthoDB" id="269124at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12153">
        <property type="entry name" value="F1-ATPase_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.20">
        <property type="entry name" value="ATP synthase, F1 complex, epsilon subunit superfamily, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006721">
        <property type="entry name" value="ATP_synth_F1_esu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036742">
        <property type="entry name" value="ATP_synth_F1_esu_sf_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04627">
        <property type="entry name" value="ATP-synt_Eps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48690">
        <property type="entry name" value="Epsilon subunit of mitochondrial F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KTW32891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="79" mass="9409" checksum="2F99891F0868CFA3" modified="2016-03-16" version="1">MFQKQIMEKEKKKSDKTYFWCLNGVLVVKNIFTYNRYSSICANIVRKCLNKNKRVEAEKREIISNWENGKQGKSETLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZX03</accession>
    <name>A0A0W4ZX03_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_04296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="KTW32892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613366.1">
        <property type="nucleotide sequence ID" value="XM_019757815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZX03"/>
    <dbReference type="GeneID" id="30671582"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04296"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KTW32892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="77" mass="9630" checksum="1CD5778562857093" modified="2016-03-16" version="1">MYYKCLKNIKTKELNKFIFNFYTLDIEIKNPKRQICRLNRLFERMFLSRFRSFLKCFILIKCRLKYKLSTSLKEFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZX26</accession>
    <name>A0A0W4ZX26_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P53 and DNA damage-regulated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_04276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="KTW32923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613392.1">
        <property type="nucleotide sequence ID" value="XM_019757797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZX26"/>
    <dbReference type="GeneID" id="30671568"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04276"/>
    <dbReference type="OrthoDB" id="20282at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KTW32923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="12902" checksum="7D1A0E5C08CC6C17" modified="2016-03-16" version="1">MIYINIKDLETKVSLEEEIYQDKKLIEIYEQRKRDNKEGLKALERLKERDKVWVNVDNLFMRQKVEETIRCIKEDEKYLELEIEKVKERLLCLCEKLEVLQNKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M1FRL4</accession>
    <name>M1FRL4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Cytochrome c oxidase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cox3</name>
    </gene>
    <organism>
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="11"/>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="FASEB J." volume="27" first="1962" last="1972">
            <title>Sequencing and characterization of the complete mitochondrial genomes of three Pneumocystis species provide new insights into divergence between human and rodent Pneumocystis.</title>
            <authorList>
                <person name="Ma L"/>
                <person name="Huang DW"/>
                <person name="Cuomo CA"/>
                <person name="Sykes S"/>
                <person name="Fantoni G"/>
                <person name="Das B"/>
                <person name="Sherman BT"/>
                <person name="Yang J"/>
                <person name="Huber C"/>
                <person name="Xia Y"/>
                <person name="Davey E"/>
                <person name="Kutty G"/>
                <person name="Bishop L"/>
                <person name="Sassi M"/>
                <person name="Lempicki RA Kovacs.JA."/>
            </authorList>
            <dbReference type="PubMed" id="23392351"/>
            <dbReference type="DOI" id="10.1096/fj.12-224444"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome c oxidase subunit 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="JX499144">
        <property type="protein sequence ID" value="AFR90410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_007475000.1">
        <property type="nucleotide sequence ID" value="NC_020332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M1FRL4"/>
    <dbReference type="STRING" id="1069680.M1FRL4"/>
    <dbReference type="GeneID" id="14657964"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01665">
        <property type="entry name" value="Cyt_c_Oxidase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.80:FF:000002">
        <property type="entry name" value="Cytochrome c oxidase subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.80">
        <property type="entry name" value="Cytochrome c oxidase, subunit III, four-helix bundle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024791">
        <property type="entry name" value="Cyt_c/ubiquinol_Oxase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033945">
        <property type="entry name" value="Cyt_c_oxase_su3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035973">
        <property type="entry name" value="Cyt_c_oxidase_su3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013833">
        <property type="entry name" value="Cyt_c_oxidase_su3_a-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11403:SF7">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11403">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00510">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81452">
        <property type="entry name" value="Cytochrome c oxidase subunit III-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Heme-copper oxidase subunit III family profile" evidence="10">
        <location>
            <begin position="2"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFR90410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="261" mass="29497" checksum="8A872EBD793E7E41" modified="2013-05-01" version="1">MYLHPYHMVHPSPWPILSSFALLSLALSSVLMFQSTEYGMLLFVGSLLSVLGSLLFWFRDIISEGSYEGSHTSVVVKGIYIGMILFLISEAFFFLSIFWAYFHSALSPTVEIGEQWPPKGIKAINPWELPLLNTVILLSSGSTVTYAHYSFIGGNRKGTFVGMFLTILLALLFTGLQGIEYLESSFTISDGIYGSCFYFGTGFHGLHVIIGTIFLIVGLYRIYNYQLTEDHHLGLEAGILYWHFVDVVWLFLFITVYWWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NHL3</accession>
    <name>M7NHL3_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_03498</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875590.1">
        <property type="nucleotide sequence ID" value="XM_007877399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NHL3"/>
    <dbReference type="STRING" id="1069680.M7NHL3"/>
    <dbReference type="GeneID" id="19897185"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03498"/>
    <dbReference type="eggNOG" id="KOG2318">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010564_0_1_1"/>
    <dbReference type="OMA" id="DHDFAID"/>
    <dbReference type="OrthoDB" id="431825at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039754">
        <property type="entry name" value="Esf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056750">
        <property type="entry name" value="RRM_ESF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202:SF0">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25121">
        <property type="entry name" value="RRM_ESF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ESF1 RRM" evidence="7">
        <location>
            <begin position="142"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="6">
        <location>
            <begin position="559"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="446"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="448"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="460"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="603" mass="70562" checksum="C76A913154B94140" modified="2013-05-29" version="1">MDQRFPVDSDPRFIRPKKRGRVVLDSRFSSILDPDFSEQPVFDLYGRRLKNRKKDIKDIESLYILPSKTCSDSNGFLVKNKDFKKKDLNEVESLKTSSEESIISLRDDSFSSEEDLSSDFSTEDLKLVDPEPEIEIPRGEMTYRLAVVNLDWDHIRSVDIFAALGSFVPKGGRILSVKIYPSEFGKKRMEKEDVEGPPRDIFSIKPSKTLSLENKAQELKEFHKETENDTDDTDNTDDINSISDEKIQKELVKEDKGNDFNMTQLRKYQLERLRYYYAIVVCDSVNTAKYIYKQCDGREYEASANFFDLRFVPDEESFDSMQIRDECLSLPEAYVPEEFVTDALKHSNVKLMWDNDDPVYLQMVKRAFSGKEINENDFKVYLASTDSEASDIEVAKKYRSLLLNNEDLLNDQENVVGDMQVTFMPGLDEKKSDEIVVETTLEKYKRKEKERKKKKKDKKHYSQENGLHDSKDQEKTDLGFNDPFFSQEPVLSKKTKQKTLDKNNLQKAQLELLMMDDNISKTNTIDHHLHIKDIRKFKKKPKSLHPQEIQDNFDIDLNDPRFSAMYSSHHFDIDPTNPRFKKTHSMIKIIKERQRRHEKLSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NIG8</accession>
    <name>M7NIG8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_03208</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875271.1">
        <property type="nucleotide sequence ID" value="XM_007877080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NIG8"/>
    <dbReference type="STRING" id="1069680.M7NIG8"/>
    <dbReference type="GeneID" id="19896895"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03208"/>
    <dbReference type="eggNOG" id="KOG0533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1050202_0_0_1"/>
    <dbReference type="OMA" id="GTCRAFF"/>
    <dbReference type="OrthoDB" id="5382468at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12418">
        <property type="entry name" value="RRM_Aly_REF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF82">
        <property type="entry name" value="THO COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="113"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="265" mass="30969" checksum="5A1760A1604F8BF0" modified="2013-05-29" version="1">MSLERSLDSIINSEKVFDNTGESSFFFCFNSPYRRLEIRDYQDGNQNDYFLKRIGLICILRHVFFLRFLGPIDLYKRNYNEPWTHDLYEGSGEKSSIGVSKQAYKQVPKPLSYRVKVENLHYELTEDDLNGLFKRIGPVSKLNIKYDRSGRSTGIAFVSFERIEDAHNAINQFNGANAAGQPITLTLDLQPSRKSQRKSDSLFGRISNFKVDPYRRKLFNNYRSYRRLEGEYKTQEDLDNELDKYMNVAIQSSNDTEKPMVIDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7NIM2</accession>
    <name>M7NIM2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_03270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875341.1">
        <property type="nucleotide sequence ID" value="XM_007877150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NIM2"/>
    <dbReference type="STRING" id="1069680.M7NIM2"/>
    <dbReference type="GeneID" id="19896957"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03270"/>
    <dbReference type="eggNOG" id="KOG0417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_13_3_1"/>
    <dbReference type="OMA" id="VHFTTRI"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000010">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2-16 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="147" mass="16406" checksum="B25708E39D45A0D2" modified="2013-05-29" version="1">MALKRINKELGDLARDPPSSCSAGPIGDDLFHWQATILGPGDSPYSGGVFFLAIHFPTDYPFKPPKVNFTTRIYHPNINSNGSICLDILRDQWSPALTISKVLLSICSMLTDPNPDDPLVPEIAHVYKSDRSRYEATAKEWTRKYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJ20</accession>
    <name>M7NJ20_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_03084</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Nibrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875140.1">
        <property type="nucleotide sequence ID" value="XM_007876949.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJ20"/>
    <dbReference type="STRING" id="1069680.M7NJ20"/>
    <dbReference type="GeneID" id="19896771"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03084"/>
    <dbReference type="eggNOG" id="ENOG502RS0G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_411093_0_0_1"/>
    <dbReference type="OrthoDB" id="552194at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22667">
        <property type="entry name" value="FHA_NBN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10980">
        <property type="entry name" value="Nibrin, BRCT2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040227">
        <property type="entry name" value="Nibrin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032429">
        <property type="entry name" value="Nibrin_BRCT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043014">
        <property type="entry name" value="Nibrin_BRCT2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162:SF0">
        <property type="entry name" value="NIBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162">
        <property type="entry name" value="NIBRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16508">
        <property type="entry name" value="NIBRIN_BRCT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="9">
        <location>
            <begin position="24"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="668" mass="77527" checksum="2D3EC709C2847A05" modified="2013-05-29" version="1">MWVLESSSTELNGIRKYLRPGKEYLVGRAKHITDITIDSKTVSKKHAKFVVVSVEKGASLLLEEKTVIYLIDLNSKFGTMVNGEKLGEFAKKCDENFQEITFGKCQGKFRLSWNPVVFTLSGIKIKDIQLLVETYGIKITKEYCNKTTHVVSKQRNTTKNLQAFIYGVFVVSYSYVQELVRTIDLLEFNFDQGFPNPEDHIPQDNHYLNINVSPKDFLPNKQRRHLFRGLTFIFFDKNQYCNLSLPINAASGKTAFCKETSNIEQITIFIRNYSNVIAVSPLDDSYFVDMACKRLRINMISQDKFFEPIVKMDLSLFEKDFYTNNDPNYKDDIVINNTKYNSQIFPTSKSELNNELTFQVFKKSDINVVSNDNDNKRDIKSSEHINEIFDKDDILSQNFSNCNKFSTKARIIYPISDNENTISVNSNIKMDSEFYSPIKSLRSQILPSNNSNIIHDIYEVDFRNTSNSPKKNALDLENSNKSTYETNSYNHLKSDLSLISTAKNFEISLPSTLQENKTNSFQTIKNESSVSHFSKSAEKDEKLKVIEYFKVELKPQKSFVNLSPRWDPKWNGRKNFKKFIRVKRIQPLTFTQHVRLVEYKPNMRLIQESSKQKSNEQIFKKNVKNTISGSDRTFIFKNKTKTFSTNIQNYFDITQDDTDDDDPLKFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJY9</accession>
    <name>M7NJY9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanine nucleotide-binding protein subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_02719</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">G proteins are composed of 3 units, alpha, beta and gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G protein gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874744.1">
        <property type="nucleotide sequence ID" value="XM_007876553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJY9"/>
    <dbReference type="STRING" id="1069680.M7NJY9"/>
    <dbReference type="GeneID" id="19896410"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02719"/>
    <dbReference type="eggNOG" id="ENOG502S5Z5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163540_1_1_1"/>
    <dbReference type="OMA" id="NGCCAVM"/>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.260.10:FF:000003">
        <property type="entry name" value="G-protein complex gamma subunit Ste18/GpgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041848">
        <property type="entry name" value="Ste18_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="G protein gamma" evidence="11">
        <location>
            <begin position="14"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR08938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="84" mass="9670" checksum="17434161C2BA5C0C" modified="2013-05-29" version="1">MVGSHKRPLKSSISELKLRRMTELNNRLKEDLERPRILVSEACQSLILFATSTKDPMLPSVWAQNDRFPGSFSNRRSFSCCILM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NK37</accession>
    <name>M7NK37_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02769</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874799.1">
        <property type="nucleotide sequence ID" value="XM_007876608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NK37"/>
    <dbReference type="STRING" id="1069680.M7NK37"/>
    <dbReference type="GeneID" id="19896458"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02769"/>
    <dbReference type="eggNOG" id="KOG1492">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048898_0_0_1"/>
    <dbReference type="OMA" id="CKRFTST"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000035">
        <property type="entry name" value="CCCH zinc finger protein, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156">
        <property type="entry name" value="CCCH ZINGC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156:SF1">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="214"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="296"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="214"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="296"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="378"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="417" mass="47981" checksum="AAC294B4FEFA97F3" modified="2013-05-29" version="1">MMEKKKYIEKEKKDRIREVAILNEIATVAGAINRHKHRRGEIENKDVEKLSFKPCSYLKNPRHRSRHMSLVISTRHSETNVNNETQSVSTGWIQKKDRHLQLINASIYDSTVKKRAKAIEETRLQKKMKQDEIFKKNKYKDARVNGIKELMIDGVKFYVKKNGYKLIRAEDNDPFVETSKKAVVSGSVFWRTKNGNLWHTSLIKSKIGDKSFEKKSEKYCQYYTRTGKCLQGKSCSYKHDPNHVAICPLFMKGKCPNKNACDLSHEPTPHRVSACLHFLRGQCLNTNCLYAHVRVNPSAPICRAFAIDGYCEKGIECREKHLRECPDFSEKGLCLIKNCRLPHIERAARKRKECFLSTSDDESSFGFERNDLISNTNAQSVERLPDKDSSSSSQSDLDTFSSPDSSSIDVDQDFIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NL68</accession>
    <name>M7NL68_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor IIIC putative zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874357.1">
        <property type="nucleotide sequence ID" value="XM_007876166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NL68"/>
    <dbReference type="STRING" id="1069680.M7NL68"/>
    <dbReference type="GeneID" id="19896046"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02353"/>
    <dbReference type="eggNOG" id="ENOG502S7UK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008513_0_0_1"/>
    <dbReference type="OMA" id="EERRMEC"/>
    <dbReference type="OrthoDB" id="6021743at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044230">
        <property type="entry name" value="GTF3C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024761">
        <property type="entry name" value="TFIIIC_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024764">
        <property type="entry name" value="TFIIIC_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15496:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15496">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12657">
        <property type="entry name" value="TFIIIC_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12660">
        <property type="entry name" value="zf-TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor IIIC 90kDa subunit N-terminal" evidence="1">
        <location>
            <begin position="19"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC putative zinc-finger" evidence="2">
        <location>
            <begin position="610"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="696" mass="80805" checksum="A0099F4797E15CD8" modified="2013-05-29" version="1">MIKNVKIGLPFTLNSCKLSKDGIIGIACGTRVQLISWNTSFQSQKKDFQVQDIDLSSYFELQENTYIFHDKKHFYLSESSDTFIKEIDWSPTGVSESKNCVLAILTSKHVVYIFKPYKNPYSNKWVLLHNISKITIKYLFNSSKPNTNITDFLKSRARCILWSPTLYTQEEKWGKCYLGIGNEYGEIELWSITSEEAVLSLKLKVLETWVTKLSFSPWIQENVNTYCSLLSVSGESGPTRIIKLSVSINNENVYLISPSIKKLYVDNNEFETPSNNSLWLLQSTILYLILIHVERISVFQCSVTFDPIFIKYLHTGTFLQASGTSIIYNGIDPIGFLVAYHNGLIQTFTFSKLSNEIEPITNNITSKLKEQLSDYMQTHSFSEFNIRIYGLSSLPPFLYQIFICEIIPSDEIRYITHKQAEAKLVFLESSNISNEKILKVVEQYVISNTHFSTTCMLWDLGLSKFFNTSYREINFLKCFDHLKKFNKEISDEICQTIPDKLFNSKFLNSQRLLNSIINMFKMKKDLETIYHTIISNLRSHLIMTVLSESNYFHQHTSCSLLTSKERKLIMLYCSFIINYFPNDNLLLSLLKIWKQHFLSSELLQIHDWKINTEEYCNVCKSNIPFKNVEFGTCEKKHTWPRCSITLFTLMDTSPKTCQNCSRKRISFSNQDHSFVSKLIDACDICFYCGGRWYSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLB0</accession>
    <name>M7NLB0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874401.1">
        <property type="nucleotide sequence ID" value="XM_007876210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLB0"/>
    <dbReference type="STRING" id="1069680.M7NLB0"/>
    <dbReference type="GeneID" id="19896089"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02396"/>
    <dbReference type="eggNOG" id="ENOG502T3NF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080510_2_0_1"/>
    <dbReference type="OMA" id="DAYYSFL"/>
    <dbReference type="OrthoDB" id="5229808at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013248">
        <property type="entry name" value="Psh3/Shr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228:SF1">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08229">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00786">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="198" mass="22858" checksum="EFE584CE48A4A2DD" modified="2013-05-29" version="1">MKKTLASYLIVCSSSFFLGILFISWIVDHFTFWMNPVTDQALLNAETYYLLLYQAPSIHKILLHILICFGFFAHVMKLYGGNKSNLLFDSGSLVLYIAGIIIYNVYLIQGILFYYYNAFYLDYLIIGLETIFQRTYISFNRIDTLRILAASHVVLALILIGILVLQSSQFCAEQTVIHSETLSKRPKKHLQSSRRLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLN0</accession>
    <name>M7NLN0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RecA family profile 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_03541</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875633.1">
        <property type="nucleotide sequence ID" value="XM_007877442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLN0"/>
    <dbReference type="STRING" id="1069680.M7NLN0"/>
    <dbReference type="GeneID" id="19897228"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03541"/>
    <dbReference type="eggNOG" id="KOG1433">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072132_0_0_1"/>
    <dbReference type="OMA" id="TQMTSKV"/>
    <dbReference type="OrthoDB" id="5957327at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000707">
        <property type="term" value="P:meiotic DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052093">
        <property type="entry name" value="HR_Repair_Mediator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3 RAD51C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="7">
        <location>
            <begin position="29"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="333" mass="37243" checksum="E1C0DB0176AF5A5B" modified="2013-05-29" version="1">MESSQIYLSSLYHRLPTTSAFDALTSDHTLSFISSSISALDSIFGGNGFKTGQITEISGPPGSGKTAIALQATINCLKKKEKILWIETFQPFPMHSLKKVITQSKKKKTKLIDYTHEEINPLNYLTILHAPSLNNLIALFLHSYKTNSKDLIQQKKLIIIDDIATPIIAAFPPDNVENQSRNSTHDLTQLKKSQVLTNLLLSFNRIAAKNNACILILSKMVIKINNINGKECAILSSPLSLSWSQNCPNKIILLRKNVDILENENNLYNNKQVRFIYIQKVGGVTINSNSLIPFIISDEGIINITNDSNNVLNTYQIESQDKVNNRDENECIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NM19</accession>
    <name>M7NM19_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">3'(2'),5'-bisphosphate nucleotidase</fullName>
            <ecNumber evidence="3 11">3.1.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_03409</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3'-phosphoadenylyl sulfate + H2O = adenosine 5'-phosphosulfate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:77640"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine 2',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:194156"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:77644"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>adenosine 3',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:10041"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.7" evidence="3 11"/>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875495.1">
        <property type="nucleotide sequence ID" value="XM_007877304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NM19"/>
    <dbReference type="STRING" id="1069680.M7NM19"/>
    <dbReference type="GeneID" id="19897096"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03409"/>
    <dbReference type="eggNOG" id="KOG1528">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033446_3_1_1"/>
    <dbReference type="OMA" id="RNERSCN"/>
    <dbReference type="OrthoDB" id="411145at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043647">
        <property type="term" value="P:inositol phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01517">
        <property type="entry name" value="PAP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000003">
        <property type="entry name" value="PAP-specific phosphatase HAL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006239">
        <property type="entry name" value="DPNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051090">
        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01330">
        <property type="entry name" value="bisphos_HAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF6">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR08242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="250" mass="27742" checksum="75740771A605ED23" modified="2013-05-29" version="1">MVSRTLEGEDRNIGYIEGRERLLEVIEHGRNERNERSCNRWWIIDPIDGTKGFLRGGQYAVCLALVENGQPCLGVLGCPNLRRNIEDNDDLGVLFYACKGEGAYQGILNGNDKSLIHMNNIENVVDARVCQSHAPGHSALETHKKIIDVLGITKPPIELDSQVKYALLARGESDIYLRLPVDPNYHEKAWDHAAGALIVEEAGGIVTDVYGKALDFSKGKRLSENHGIVAASKYLHAKVLEAVMFILKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NM40</accession>
    <name>M7NM40_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_03376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875459.1">
        <property type="nucleotide sequence ID" value="XM_007877268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NM40"/>
    <dbReference type="STRING" id="1069680.M7NM40"/>
    <dbReference type="GeneID" id="19897063"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03376"/>
    <dbReference type="eggNOG" id="KOG0379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005349_2_1_1"/>
    <dbReference type="OMA" id="CPMLIYS"/>
    <dbReference type="OrthoDB" id="10001928at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF2">
        <property type="entry name" value="NEGATIVE REGULATOR OF SPORULATION MDS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="632" mass="72000" checksum="A397724C972A2C67" modified="2013-05-29" version="1">MEEISNCLNNLASLALSTTGEIPPPLVGCSFTLIGTKLYVFGGRLVSNWNLTNDLYVLDLESYIWTKIHNLSPHLPEPRYFHSADIYLNSIYVFGGIGLSKNPDNPYCLLDDIVVFDLQFGKWKKIMVPPSSYFPKPRYAHLSVINMNYLMIIGGQDLENNYIEEANCFDLNMHIWSSSFVFNKHCGLYRSVASCKMETFPECALNLSEKNTLISEIASSYQSSPFQSKRKSLSISESSRRLSAHSEISNLLYHSQAKKSFDGTQKSDGELISTHVQYVSNNPIFIYSNYNFKNLKNELYMITSLEDDQYNIVDISDKFSGELKPSGLRFPSGGILGDHLVIFGTYLTNTTHSYSIWCIDLNSLTWSRIDPGPLLDEGSWNKGIIDYDKNCLLIFGNKEQDLVEDYNHRRINFDHIILVELEAFGVYRVTIPKMSLAAQELGLMMLEDPSFSDMEMLTQDNVILPCSTKVLSTRWPRFHSFFKASLKKDTTEFSTYDFLTKNQRNTLTLHNNLTQLSSSGPSSARFYNRSRTLYIPHPSSVVQQFLRFLYTYSLEPNILDDISALFALLSLSKSFGPDLEVKDLSLYIFYALQKCLTSQNASSIYEMAVLYGHRGLQIRSLKLISSLKKDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7NM65</accession>
    <name>M7NM65_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cleavage and polyadenylation specificity factor subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nudix hydrolase family. CPSF5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875534.1">
        <property type="nucleotide sequence ID" value="XM_007877343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NM65"/>
    <dbReference type="STRING" id="1069680.M7NM65"/>
    <dbReference type="GeneID" id="19897133"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03446"/>
    <dbReference type="eggNOG" id="KOG1689">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068704_0_0_1"/>
    <dbReference type="OMA" id="NDEWEIG"/>
    <dbReference type="OrthoDB" id="277288at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18871">
        <property type="entry name" value="NUDIX_Cfim25_Nudt21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000005">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016706">
        <property type="entry name" value="Cleav_polyA_spec_factor_su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13047">
        <property type="entry name" value="PRE-MRNA CLEAVAGE FACTOR IM, 25KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13869">
        <property type="entry name" value="NUDIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017888">
        <property type="entry name" value="CPSF-25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR017888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="239" mass="27712" checksum="1C7890A43851C3FD" modified="2013-05-29" version="1">MASKLYPLQKGFNERQPETVRLYPLSNYVFSTKEAQPEEDPSVISRLERLKSHYEKNGMRRTCEGILVVHEHNHPHILMLQIANAFFKLPGDYLRPNEPEIQGFVARLNERLAPTTPESPEDMKWEIGDCLAQWWRPNFETFMYPFIPAHVTRPKECKKLYLIKLPKTKVLAVPKNMKLLAVPLFELYDNSARYGPQLAAIPQYLAKYNFEFVDSNDRVIVQTPGNTMGDGTVVRNNVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMD2</accession>
    <name>M7NMD2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_03212</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875275.1">
        <property type="nucleotide sequence ID" value="XM_007877084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMD2"/>
    <dbReference type="STRING" id="1069680.M7NMD2"/>
    <dbReference type="GeneID" id="19896899"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03212"/>
    <dbReference type="eggNOG" id="KOG2889">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039466_2_1_1"/>
    <dbReference type="OMA" id="GEHFKYL"/>
    <dbReference type="OrthoDB" id="190958at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="198" mass="23576" checksum="961F96BC9DB969B9" modified="2013-05-29" version="1">MEASETRKDESYMEQSIHSMNPVNLIEKIIRERILECRYYKEMCFGLTAATICDRAVKMKYIGGQYLNQRPTEFLCLTFKLLQLQPEKEIILEYLYANDFKYLQALAAFYIRLTFPAKECYLILEPFLNDYRKLRIRYSTGLYGLSYIDEFVDHLLNQERVCDIALPRLPTRFILEEMEELEPRKSALESELETDEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMD3</accession>
    <name>M7NMD3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADP-dependent L-serine/L-allo-threonine dehydrogenase ydfG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02009</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873989.1">
        <property type="nucleotide sequence ID" value="XM_007875798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMD3"/>
    <dbReference type="STRING" id="1069680.M7NMD3"/>
    <dbReference type="GeneID" id="19895703"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02009"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_1"/>
    <dbReference type="OMA" id="NVCVREI"/>
    <dbReference type="OrthoDB" id="6251714at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004090">
        <property type="term" value="F:carbonyl reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052588">
        <property type="term" value="F:diacetyl reductase ((S)-acetoin forming) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031132">
        <property type="term" value="F:serine 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045149">
        <property type="term" value="P:acetoin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="28524" checksum="60B768652F8EC21E" modified="2013-05-29" version="1">MSRLSNKTIFITGASSGIGKACAYEFAKTNNTVKLIISARRDVTEIAKDIESTFPGVKVLPLRLDVSKLEDIEEKIEGLPDSFKDIDILINNAGFVIGMERVGEINPGIMMDMFSTNVFGLINITQKILNIFHQKGGKGDIINIGSIAGREPYPNGSIYCATKAAVRSFTNSLRKELINTRIRVIEIDPGLVKTEFSIVRFCGDKSRADAVYQNMEPLTGEDVAEAIVFAASRRENVVIADTLIFPNCQASISHVYREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMI0</accession>
    <name>M7NMI0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_03166</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875229.1">
        <property type="nucleotide sequence ID" value="XM_007877038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMI0"/>
    <dbReference type="STRING" id="1069680.M7NMI0"/>
    <dbReference type="GeneID" id="19896853"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03166"/>
    <dbReference type="eggNOG" id="KOG2604">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_366851_0_0_1"/>
    <dbReference type="OMA" id="CEDLITH"/>
    <dbReference type="OrthoDB" id="296793at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048685">
        <property type="entry name" value="COG3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048320">
        <property type="entry name" value="COG3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007265">
        <property type="entry name" value="COG_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302:SF8">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20671">
        <property type="entry name" value="COG3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04136">
        <property type="entry name" value="COG3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 N-terminal" evidence="9">
        <location>
            <begin position="104"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 C-terminal" evidence="10">
        <location>
            <begin position="267"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR08326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="760" mass="89597" checksum="4174E4B3A395DB61" modified="2013-05-29" version="1">MVFYKGSCLMNEESSEYLGLDTSVVNDFEEKDVSYLLKNKHIFSEKKEQITRSLSLNDLKHVYETFYFSQVARNMNYYRSLVWSNEMEKSIQNQQDLHFRLFKKEYLEKISICEDLITHVSKMFEKLRVINIDLKKSYENSHVFRNNYEKLEKEKQNAILLKDQIRQNLEAYCSLDVIYKLLNTSGVELITKPEFFDMLKKLDKGSQMMKEHPEFKNSWIYREKFEQCLTKAMTLICVFFVQVIKELNEGINEDFSFKVSNNINQTAFLYTKFRVRAIELRPYIKEIEERIKDHNEYNVMINDCQKFYFGIRYKLVKPIISQKLNELSNENIIRFSRISIAFFTGLCFDEFSLFRDFFQNDDSKFYSYSQKLFEPISTYLQSNLFKETNLSLLCEVCSVFKVKISEDSENENSLDIGQDCYKIDYSVIFNEIIQHIQSFIVVQVRNVAKLEIQNFIPSKNAFNFSKTLEKRDQSDSLLTKVSDVSKEELYDSDLVIRWYPTLNKTISLLSKIYPLLNTKSFNTVAYDIVNICISSLSHGSQVQTDISMRDRQLFLVKHLLILRNQILEFNIDFFHFEKDVNIDTANISSWDVYNKLRLFNPLELYKSAWSKISGFSSTERDIYNKFNTLLQTAINASIEHSLKPFIEPIQKIRKIKKLSNDSIEAIINESLISIEKEAPLLRITFLSYIEDSQIIHIFFIDIIDKFSKELGDIGKCLSPEYLTTWSQTDQLISCLSRLLLNNNSSEKVSKTAHQDIIMIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMX1</accession>
    <name>M7NMX1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA-binding protein VTS1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">RNA-binding protein vts1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_03303</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA-binding protein involved in post-transcriptional regulation through transcript degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875378.1">
        <property type="nucleotide sequence ID" value="XM_007877187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMX1"/>
    <dbReference type="STRING" id="1069680.M7NMX1"/>
    <dbReference type="GeneID" id="19896990"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03303"/>
    <dbReference type="eggNOG" id="KOG3791">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017632_0_0_1"/>
    <dbReference type="OMA" id="MSTVNNR"/>
    <dbReference type="OrthoDB" id="2155283at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09556">
        <property type="entry name" value="SAM_VTS1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000033">
        <property type="entry name" value="Protein vts1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050897">
        <property type="entry name" value="SMAUG/VTS1_RNA-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057327">
        <property type="entry name" value="Vts1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037635">
        <property type="entry name" value="VTS1_SAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515:SF5">
        <property type="entry name" value="PROTEIN SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25479">
        <property type="entry name" value="Vts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SAM" evidence="13">
        <location>
            <begin position="499"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR08475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="563" mass="63147" checksum="D56048F9C3431A87" modified="2013-05-29" version="1">MMSVTPTLEHDKSSLKHLSSKIQRNYQIRTSFDLSNFNSPLSGRNNRPTSEVFLRTPQKTQMPEVAAFDKWLEDLQSYENTLEEMASASLDQNFKEELRAIEQWFRVLSEAERTAALYALLHQTTQVQVRFFITILQQMAHSDPMNAFLSPTNLDKDSMQNNLSGTMSQINHDRKNGTIMKLLSPSINHSSSQIQNGSYLDAKAVNTMFPNTSSALANQKTRLNTNCNTSVFTDTHNQDTIPIRNNNSPIMLKHDVCPSPLWSQPLNKISENTPLGFNRPKSADIEKNQDTQQLNSLATHNPSSNPDYGEFSPFSPGGNWASMVNTPLVPMFSQTPSQSNDLKAATSKLSSLSLSMQNNDPIILDTDVKKYHRGKSTLLSSTADKNGFNQHPTNVLMYTEHGHLMQMSSQRSISSPLLSRKISPKSESSIPPGFSEQSGWHMPVSSHSNGYLAPFDASSPLLATEEYISDNSDAIITNRKGRRLTSKPPENPVNDLLLNDIPAWLRGLRLHKYSDNLGDMNWKELIEMTDEQLEMKGVAALGARRKLLKSFDQIKEARNLGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN02</accession>
    <name>M7NN02_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c oxidase subunit 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01814</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873785.1">
        <property type="nucleotide sequence ID" value="XM_007875594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN02"/>
    <dbReference type="STRING" id="1069680.M7NN02"/>
    <dbReference type="GeneID" id="19895508"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01814"/>
    <dbReference type="eggNOG" id="KOG3352">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1687422_0_0_1"/>
    <dbReference type="OMA" id="KTRECYL"/>
    <dbReference type="OrthoDB" id="10249250at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990145">
        <property type="term" value="P:maintenance of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00924">
        <property type="entry name" value="Cyt_c_Oxidase_Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.11.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002124">
        <property type="entry name" value="Cyt_c_oxidase_su5b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036972">
        <property type="entry name" value="Cyt_c_oxidase_su5b_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01215">
        <property type="entry name" value="COX5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57802">
        <property type="entry name" value="Rubredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51359">
        <property type="entry name" value="COX5B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602124-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="17853" checksum="757567A0B32F701F" modified="2013-05-29" version="1">MNILNKTRECYLSSFFFKKRLIQVLRINKVIYKIERNFITKSYIKNDKNPKPVEGKVPSSLEQATGIEKYELLQKLSGKDAFDLKPLDASRLGTLKDPIVVESLDKTRLIGCTGFPVDSHDVLWFELSVNKENSRCPECGSVYKLNFTGGDIQNHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN57</accession>
    <name>M7NN57_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Replication factor A protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02843</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874877.1">
        <property type="nucleotide sequence ID" value="XM_007876686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN57"/>
    <dbReference type="STRING" id="1069680.M7NN57"/>
    <dbReference type="GeneID" id="19896530"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02843"/>
    <dbReference type="eggNOG" id="ENOG502SBIR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141922_2_0_1"/>
    <dbReference type="OMA" id="HRYKEIF"/>
    <dbReference type="OrthoDB" id="188186at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04479">
        <property type="entry name" value="RPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013970">
        <property type="entry name" value="Rfa2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114:SF1">
        <property type="entry name" value="REPLICATION PROTEIN A 14 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114">
        <property type="entry name" value="REPLICATION PROTEIN A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08661">
        <property type="entry name" value="Rep_fac-A_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="11620" checksum="EAEBD22073E84121" modified="2013-05-29" version="1">MDKPTPRINVSLCEQFVDQTVRMIVKVKKLKGDTALVDSCGLIEVHLNRDSNFIEGNAFEIIGKINPDLSVNVLTAINFGKDIDFEAVNLVVQVSHKYHELFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNA2</accession>
    <name>M7NNA2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02885</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874922.1">
        <property type="nucleotide sequence ID" value="XM_007876731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNA2"/>
    <dbReference type="STRING" id="1069680.M7NNA2"/>
    <dbReference type="GeneID" id="19896572"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02885"/>
    <dbReference type="eggNOG" id="KOG0585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="OMA" id="MACGPCM"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF77">
        <property type="entry name" value="SERINE THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="62"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="388" mass="45051" checksum="7214700F062008B8" modified="2013-05-29" version="1">MSNNSIEKVRKKAGKRSSSTSEDRLLLFRESEKVLGSFKSSFKETLDVFLSDDDGFNRLNRYDIKDQIGHGSFGAVNRCIDMLTGEEYAIKEFSKVQLKKVYGYSRFSHFKSESDSFIYNNDISSYWHVKNNYEQNNNPFFYIKEEIDIMKKINHRNIVNMIDVLDDPNGDSIYIVLEMCEKGALMDLDLNKIATPYSETDCRRWFRDLMLGVEYLHFNGICHCDIKPENLLLSKDGILKITDFSISKMFRRDDSFRKIKGTPAFMAPELCFPEGNAVSCRAADIWSMGITLWCLRFGCLPFYDSDIVKLYDMIKTKEIVIPQYISPSLKDLFEKILEKIPEKRIKLHDLRKHSWITQDGIDPLITYEENVMGSTANSTRNFDSSSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNW4</accession>
    <name>M7NNW4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_02951</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874996.1">
        <property type="nucleotide sequence ID" value="XM_007876805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNW4"/>
    <dbReference type="STRING" id="1069680.M7NNW4"/>
    <dbReference type="GeneID" id="19896638"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02951"/>
    <dbReference type="eggNOG" id="KOG0239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_12_1_1"/>
    <dbReference type="OMA" id="MCRVRPP"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01366">
        <property type="entry name" value="KISc_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000065">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF45">
        <property type="entry name" value="PROTEIN CLARET SEGREGATIONAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="462"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="56"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="164"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="365"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="556"/>
            <end position="563"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR08781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="815" mass="92345" checksum="35F4321B82C7307B" modified="2013-05-29" version="1">MEEKNQSRLPQPLSRMVSPITKIKTNPLADSTSSVNIIPQRNVSGTKRSLKDLEINVSDNSKKKNTTVSERKTLVERAVAPRKPSGSSNNRSSVNENNKSVSVYQKTCQPGLSRSLNGGHVRSASTLGGNLPNTMLNSQTIQRSGTKTLGDRPKRPAWDTRGRLEDMEIAYSELKEQISIGNAEKDAIITALESERHKLNELEVVKKSLMNELEEARSFLLTRKLEMDEQLSKLRCENLELERKLDDERRQFRNEMDDFVRKNRDEIDLLERKHRDEIKSLEKTYKEEIDEIKQDGKQKLESLVSYYKNEMEMMEKKHTTAIEEACSQSILELQKFKIESALEKQKADLAFDAKERELQMTKISLNEVTSDLEREKILNVSLRNEINEKCVSNLTLESSVSVFRTEIGKLESQIASQKADIEEFSRLAKDAQEEKEIYCKKLREEETFRRKLHNQIQELKGNIRVFCRVRPFLEHEKPENGAVDIKYPDESKEGKEIEIFGQTVESSLGSVHSKSYPFSFDKVFSPKCSNDMIFDEISQLVQSALDGYNVCIFAYGQTGSGKTYTMCAKDGMIPRAVNQIYNTAHALSEKGWCYSMEGQFLEIYNEHINDLLGHPDEFDKKKHEIRHDPKECRTIVTDLTTVVLDTPSKVSSILKKASNNRFVAATHANERSSRSHSVFILTLYGTNSITGETSRGTLNLIDLAGSERLSQSQSIGDRLKETQAINKSLSCLGDVISALSNPKGHIPYRNSKLTYLLQYSLGGHSKTLMLVTLSPLLQHLSESLCSLRFATKVNNTVIGTARKTSKVQNVSLTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNX3</accession>
    <name>M7NNX3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02961</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875006.1">
        <property type="nucleotide sequence ID" value="XM_007876815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNX3"/>
    <dbReference type="STRING" id="1069680.M7NNX3"/>
    <dbReference type="GeneID" id="19896648"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02961"/>
    <dbReference type="eggNOG" id="KOG3154">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035060_4_2_1"/>
    <dbReference type="OMA" id="DCSWESA"/>
    <dbReference type="OrthoDB" id="10262062at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:rRNA small subunit aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426:SF0">
        <property type="entry name" value="18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal" evidence="7">
        <location>
            <begin position="19"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="191" mass="21952" checksum="26C6BAFD45520999" modified="2013-05-29" version="1">MARLGLIKTLKMGQKWNGIILSHDKELFLSKEDAPLLREMGVAVIECSWQRIDEIPSRYIRGRNFRALPYLIAANSVNYGRPWKLNCAEALATCLYIAGYQSYAHILLSYFSWGETFFRINSEFLDSYASCSNNFDIKMAQDSLLSSLSTEYLENKQNSIIFPSEDSFEETSHSENDDINFQKKQTSLSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP36</accession>
    <name>M7NP36_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02651</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the INSIG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874672.1">
        <property type="nucleotide sequence ID" value="XM_007876481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP36"/>
    <dbReference type="STRING" id="1069680.M7NP36"/>
    <dbReference type="GeneID" id="19896342"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02651"/>
    <dbReference type="eggNOG" id="KOG4363">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_909501_0_0_1"/>
    <dbReference type="OrthoDB" id="205546at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025929">
        <property type="entry name" value="INSIG_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15301">
        <property type="entry name" value="INSULIN-INDUCED GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15301:SF3">
        <property type="entry name" value="PROTEIN NSG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07281">
        <property type="entry name" value="INSIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="306" mass="35956" checksum="F5314D3B41F6BF88" modified="2013-05-29" version="1" fragment="single">MNDNMFIHDQVQRSDSYDSFNSWGFFNLSSNQILKEDGSSSISEIFMKQKSSIFLPLNGIKDGSSALFSIYSSLLDEPETPKVFYKQKKDLKCHYKSFLFIRRFWTFLLKFICLYIWGRVITIFVFHAQMKENITSPYKFEILTHIPHFRTLYSLGMALFGFLTPVIDSLMYKFGFTQASKNAYQIEIPNSKYIEIFEIMRVFSTFTGIVYAFVKLSWVLDVKASLFLFFIGFSMWFIFDRAQTGFFLSSITSIIFTIILSFTSDIFKNEDLMRKEIFGIRSWILGFFFSSCITASNIGRRLFRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP46</accession>
    <name>M7NP46_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01196</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873112.1">
        <property type="nucleotide sequence ID" value="XM_007874921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP46"/>
    <dbReference type="STRING" id="1069680.M7NP46"/>
    <dbReference type="GeneID" id="19894893"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01196"/>
    <dbReference type="eggNOG" id="ENOG502S4CU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097653_0_1_1"/>
    <dbReference type="OMA" id="HICAMYG"/>
    <dbReference type="OrthoDB" id="9995210at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="80"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="166" mass="18620" checksum="824DF870C681D2B4" modified="2013-05-29" version="1">MEYDGASPSEILLNACHKENPYLLNQILDDPSTDISLINNSRDGLGNTALHLSVQYGSIACLNVLLDVKDLEINSKNFLEENTPLHKAVEYQYKDEDIALEMVESLIDAGADPRMKNKMKQKPIDLVDQQHSGIRDVLKKAELVYFTSKNDIQSTDNESETFSSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP54</accession>
    <name>M7NP54_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA (guanine(37)-N1)-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA methyltransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TRM5</name>
        <name evidence="12" type="ORF">PNEG_02819</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="10">Predominantly in the mitochondria and in the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRM5 / TYW2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="10"/>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874853.1">
        <property type="nucleotide sequence ID" value="XM_007876662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP54"/>
    <dbReference type="STRING" id="1069680.M7NP54"/>
    <dbReference type="GeneID" id="19896508"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02819"/>
    <dbReference type="eggNOG" id="KOG2078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022610_2_2_1"/>
    <dbReference type="OMA" id="VGSHSQF"/>
    <dbReference type="OrthoDB" id="408788at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070901">
        <property type="term" value="P:mitochondrial tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.110:FF:000001">
        <property type="entry name" value="tRNA (guanine(37)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03152">
        <property type="entry name" value="TRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025792">
        <property type="entry name" value="tRNA_Gua_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF36">
        <property type="entry name" value="TRNA (GUANINE(37)-N1)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="11">
        <location>
            <begin position="80"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="207"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="235"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR09047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="382" mass="43915" checksum="738F0DC14DC780D0" modified="2013-05-29" version="1">MKRIIPVVYGDSSFKKIILRPEVSAQNISKLTERSYKFIRDNNISIVPYLLELDYDFWSSDDILNAILPENLLEEVPCGFTQVGSIAHMNIREEYLPYKKIIGEVILSKNKGIRTVVNKVDTIDTKFRNFKMEVLAGENNFFVQHSESNCLFKFDFSKVYWNSRLSYEHNRLIELFQKGDAICDVFAGVGPFSIPAGKKGAIVFANDLNPDSYESLKENISLNKVDLLVRAYCKDGRQFIRDSVQELLDFSKQKIIKISHENNSKSQKKISKFENILIPQVFKHFVMNLPETSIEFLDAFKGIYSEHKHLFFSNKNSLPIIHVYCFSKIDPPDDLISKLSSSLGTELSKSDVNVYCVRKVSPNKAMYCCSFKFPESVAFNYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPQ3</accession>
    <name>M7NPQ3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein BFR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02432</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AATF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874438.1">
        <property type="nucleotide sequence ID" value="XM_007876247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPQ3"/>
    <dbReference type="STRING" id="1069680.M7NPQ3"/>
    <dbReference type="GeneID" id="19896125"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02432"/>
    <dbReference type="eggNOG" id="KOG2773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018299_0_1_1"/>
    <dbReference type="OMA" id="LEHEHAC"/>
    <dbReference type="OrthoDB" id="5783963at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025160">
        <property type="entry name" value="AATF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039223">
        <property type="entry name" value="AATF/Bfr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012617">
        <property type="entry name" value="AATF_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565">
        <property type="entry name" value="AATF PROTEIN APOPTOSIS ANTAGONIZING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565:SF0">
        <property type="entry name" value="PROTEIN AATF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13339">
        <property type="entry name" value="AATF-Che1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08164">
        <property type="entry name" value="TRAUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AATF leucine zipper-containing" evidence="5">
        <location>
            <begin position="38"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Apoptosis-antagonizing transcription factor C-terminal" evidence="4">
        <location>
            <begin position="219"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="310" mass="36494" checksum="15FB04FB4FD1D6A9" modified="2013-05-29" version="1">MISLMRKQKKKRRNELKSFIENEQKNFVQEIAKMNSLEIEKGKHIQTQIKIYDSLLDARIRLQKALVAVNSLSIDYKINDLEKNKLFIKNVENESNSLIGCLSEIRKTLIEMDKIDVEYTLERNKDFSKSSLESLCDNVIDLDKQILTWQNETLLKWSDKVKATSVLSLNKFNSLNQNILDLIQKNMTNKEKLLEATYIDRTEKKQPKNKERFDDTDFYQALLFNLINKRMVDSGNTQGLRWSILKQKKQKNNIDTKASKGRRLRYHVHEKIQNFMTPNPVNLWVEEKIDNLFSSLFGQIPLDNIMKTCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPS8</accession>
    <name>M7NPS8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP synthase subunit J, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872773.1">
        <property type="nucleotide sequence ID" value="XM_007874582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPS8"/>
    <dbReference type="STRING" id="1069680.M7NPS8"/>
    <dbReference type="GeneID" id="19894561"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00863"/>
    <dbReference type="eggNOG" id="ENOG502RAAZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174950_1_1_1"/>
    <dbReference type="OMA" id="KPMWPFY"/>
    <dbReference type="OrthoDB" id="5520611at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006995">
        <property type="entry name" value="ATP_synth_F0_jsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28060">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT J, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28060:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT J, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04911">
        <property type="entry name" value="ATP-synt_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="63" mass="7514" checksum="0287CADE90999336" modified="2013-05-29" version="1">MKKWPTPFNQPLIPFFIAGGLVFYGVYRMADAMMQSEPYINDPRNPRGIYSYFIFYIKTYSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ91</accession>
    <name>M7NQ91_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PDZ GRASP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02379</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874385.1">
        <property type="nucleotide sequence ID" value="XM_007876194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ91"/>
    <dbReference type="STRING" id="1069680.M7NQ91"/>
    <dbReference type="GeneID" id="19896072"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02379"/>
    <dbReference type="eggNOG" id="KOG3834">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025095_0_0_1"/>
    <dbReference type="OMA" id="NRRHETT"/>
    <dbReference type="OrthoDB" id="3318at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000026">
        <property type="entry name" value="Golgi reassembly stacking protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007583">
        <property type="entry name" value="GRASP55_65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024958">
        <property type="entry name" value="GRASP_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893">
        <property type="entry name" value="GOLGI REASSEMBLY STACKING PROTEIN GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893:SF0">
        <property type="entry name" value="GRASP65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04495">
        <property type="entry name" value="GRASP55_65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51865">
        <property type="entry name" value="PDZ_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PDZ GRASP-type" evidence="6">
        <location>
            <begin position="24"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ GRASP-type" evidence="6">
        <location>
            <begin position="113"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR607583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="304" mass="34380" checksum="1FC7979014A459B8" modified="2013-05-29" version="1">MWSSLKRQLSAALRGEDEERSRTHGFHVLRVVEGSVADKAGIESYYDFICEVDGVELTEDFGWLSTYLLGADRPLRVVIWSLKDQMERCILLLPSEHFGLSLRWCSISVAQKVVWHVLSIETGSPAEAAGLFPYDDYIVGTPEDLLRSESDLGTLIDNYMNRSLGLYVYNRRHETTRLVILIPNRKWGGSGALGCGLGYGYLHRLPGITRKKIQPVSKVSETFVYEELQDTLGIPLTETEKMLGVSLNSQLTSQTKLKTKSRKTNKVFDEEILELMKEGEEKSQEIERKVVFVSPEPVSQETTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQN1</accession>
    <name>M7NQN1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SUMO-conjugating enzyme UBC9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin-conjugating enzyme E2-18 kDa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_02158</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874139.1">
        <property type="nucleotide sequence ID" value="XM_007875948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQN1"/>
    <dbReference type="STRING" id="1069680.M7NQN1"/>
    <dbReference type="GeneID" id="19895851"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02158"/>
    <dbReference type="eggNOG" id="KOG0424">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_12_0_1"/>
    <dbReference type="OMA" id="TWECGIP"/>
    <dbReference type="OrthoDB" id="6600758at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106068">
        <property type="term" value="C:SUMO ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061656">
        <property type="term" value="F:SUMO conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000035">
        <property type="entry name" value="SUMO-conjugating enzyme ubc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="13">
        <location>
            <begin position="4"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR09572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="157" mass="18174" checksum="FB3E3574EC0F9090" modified="2013-05-29" version="1">MSALCRRRLQEERKQWRKDHPFGFYAKPNKLPDGTMDLMNWSVGIPGRPKTSWEGGMFKLTMFFPEEYPTKPPKCKFTPPLFHPNVYPSGTVCLSILNEEESWKPAITIKQILLGIQDLLNDPNPNSPAQSEAYTLFKKDRAAYEKRIRQQAREMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQN2</accession>
    <name>M7NQN2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DUF1640 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02356</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874360.1">
        <property type="nucleotide sequence ID" value="XM_007876169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQN2"/>
    <dbReference type="STRING" id="1069680.M7NQN2"/>
    <dbReference type="GeneID" id="19896049"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02356"/>
    <dbReference type="eggNOG" id="ENOG502S3SM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_956826_0_0_1"/>
    <dbReference type="OMA" id="ILERSKW"/>
    <dbReference type="OrthoDB" id="5424147at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024461">
        <property type="entry name" value="CCDC90-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360:SF12">
        <property type="entry name" value="MOZ PROTEIN REPRESENTS A CHROMATIN-ASSOCIATED ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07798">
        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="34080" checksum="C0785C1E592C999F" modified="2013-05-29" version="1">MLKLTNYNLKFKITQNYRLWFLYPLARKYKPQHKAIIQSYFNSHFHLYLQRRKNTEEPKKDAILIHSHIPTSKILLTKLKNSSKFSIHQFDTYNLVSTLETTGFTHSQAVAIMKSIHALINNLEAAKTKFISRSNLENETHLFHTSQSELKTEIQSMRKNETTVLRAETSNLRKQLETLEQTLKEDLMALKNDVAIDVNERKNSNKVEEKDIEIKIQELNNKFTIILGEIRAILERSKWDATRYGMCKFFLLQQNLNIIKVAIFIIAGFALIVISMQETIQKKTHKIKSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQW0</accession>
    <name>M7NQW0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="6">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00705</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 8">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872604.1">
        <property type="nucleotide sequence ID" value="XM_007874413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQW0"/>
    <dbReference type="STRING" id="1069680.M7NQW0"/>
    <dbReference type="GeneID" id="19894403"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00705"/>
    <dbReference type="eggNOG" id="KOG1255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052104_1_0_1"/>
    <dbReference type="OMA" id="VIICITE"/>
    <dbReference type="OrthoDB" id="1664372at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000005">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004230">
        <property type="entry name" value="PRK05678.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="9">
        <location>
            <begin position="41"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="6 7">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="53"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="132"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="336" mass="35990" checksum="9A099600A1CDAA9C" modified="2013-05-29" version="1">MLTRRFIRSYFKHSLSRICSFSTCFVAHQNLYDETLKNLRLTKETRVIFQGFTGKQATFHAQQAIDYGTCVVGGTNPKKAGTMHLSLPVFKDVKEAMKNTKVDISAIFVPPPLAADAIVEAIEAEVPLVVVITEGIPQYDMIRINQILKVQSKTRLIGPNCPGIIAPGRCKVGIMPSHIHKQGNVGIVSRSGTLTYEAVNQTTNIGLGQSLVIGIGGDPFPGTNFIDALTFFLKDEETKGIIIIGEIGGSAEENAAEFLKEANLFSSSPKPIVSFIAGISAPPGRRMGHAGAIVTGGKGTANTKISALEKAGVIVSKSPARLGALLYDEFVKHGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQX9</accession>
    <name>M7NQX9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">10 kDa heat shock protein, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01852</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GroES chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873823.1">
        <property type="nucleotide sequence ID" value="XM_007875632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQX9"/>
    <dbReference type="STRING" id="1069680.M7NQX9"/>
    <dbReference type="GeneID" id="19895546"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01852"/>
    <dbReference type="eggNOG" id="KOG1641">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132825_0_2_1"/>
    <dbReference type="OrthoDB" id="184876at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF0">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082571" description="10 kDa heat shock protein, mitochondrial" evidence="4">
        <location>
            <begin position="24"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="11405" checksum="021EE714D0D3BDE7" modified="2013-05-29" version="1">MYYFLFKLFTFLLFDLFFRRIKPLSNVIANIRFRSLEKLSEGKVIAVGPGGLDKDGKMVKTNVKVGDKVIIPAYGGSNIKVGDQEYQFYHDYELLATISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NR15</accession>
    <name>M7NR15_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="5">PPIase</shortName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00758</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872660.1">
        <property type="nucleotide sequence ID" value="XM_007874469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NR15"/>
    <dbReference type="STRING" id="1069680.M7NR15"/>
    <dbReference type="GeneID" id="19894456"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00758"/>
    <dbReference type="eggNOG" id="KOG0884">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_16_3_1"/>
    <dbReference type="OMA" id="FHEATPK"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01928">
        <property type="entry name" value="Cyclophilin_PPIL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000012">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF2">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="6"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="161" mass="17807" checksum="E082625A8FDA39E0" modified="2013-05-29" version="1">MSVTLHTDVGDIKIEIFCELVPQTAYNFLALCASGYYNGCLIHRNIKGFIVQMGDPTGTGKGGTSIYGKHFADEFHSLLKHNGRGVVSMANSGPDTNGSQFFITYTKHPHLDGKYTVFGRVIDGVDTTLNTLEKLQVNEKYRPLKEVYLKNITIHANPLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M7NR94</accession>
    <name>M7NR94_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_02224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874208.1">
        <property type="nucleotide sequence ID" value="XM_007876017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NR94"/>
    <dbReference type="GeneID" id="19895917"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02224"/>
    <dbReference type="HOGENOM" id="CLU_642694_0_0_1"/>
    <dbReference type="OrthoDB" id="5375567at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR09641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="427" mass="48847" checksum="F91F7D82449DB904" modified="2013-05-29" version="1">MGNTQGKQSFYEKKTSAGRLTKKWKNRGYYNGSIFKNRYTGTPIYQFADIFDPGTNLISKSDECYPKNTKQKNDVSSMYLDTSNIRFPINGKKEFLRSRNQYPSKRYRIDLLNSKTPCHYFPSKTLQCQNFSNTIPCSNSVRHNSIVSNTSCYNSSPFTLLDETLPTLSSYSTRLSNKRLTSSSNVDFGLISPGVLRVVNGNPSPCSSDDELSLLSFSQGRSLPYTIEENKLKRSVTPEPKRIVSEDMLKHTPSPSSTTEELLKEYYDHKDKNTDDYFQTDGNSKMTQFNHILDKSKQSSNPILKTKNSKQNYPITYAQDEIRSKSFSNHTHEHKNNNSIKHLRKLDVHSKALKDDSLNIFSKINNSETHTNDFLQKKSGIQERINNNQQQIHKNTKSYLVYNNIDIPSIPSIPNLFVSDQRIAISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRP9</accession>
    <name>M7NRP9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Calnexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_00446</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the calreticulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872324.1">
        <property type="nucleotide sequence ID" value="XM_007874133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRP9"/>
    <dbReference type="STRING" id="1069680.M7NRP9"/>
    <dbReference type="GeneID" id="19894144"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00446"/>
    <dbReference type="eggNOG" id="KOG0675">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018224_1_2_1"/>
    <dbReference type="OMA" id="SGCGKWE"/>
    <dbReference type="OrthoDB" id="1938156at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.250.10:FF:000001">
        <property type="entry name" value="Calnexin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000011">
        <property type="entry name" value="Probable calnexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018124">
        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF1">
        <property type="entry name" value="CALNEXIN 14D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00804">
        <property type="entry name" value="CALRETICULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006776369" description="Calnexin" evidence="9">
        <location>
            <begin position="20"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="519"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="523"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="141"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601580-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR11423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="562" mass="63591" checksum="BFDBA759FC75F237" modified="2013-05-29" version="1">MVGLLRLCILLVISGIARFSKNVGVYASIKNEGLSEKQPTFEVVYLKNAGFVEQFTEDWKERWIVSSALRHTDGNDTFFYVGEWRVEEPLVYKGIIGDKGLVLKTVAAHHAISAKFDKPINNKGKTLVVQYEVMLQNRLECGGAYLKLITESNEDIRYKEFSDKTPYTIMFGPDKCGATNKVHFIFRHKNPITGKYEEKHLKSPPVIDDSKFTTLYTLIVRPDQSYEVRINNKVSKSGNLLTDFEPPVNPNKFIVDPLDKKPEDWVDQAKIADPNAKKPDDWDEDEPFEILDVNAVKPADWLENEPLMVPDPDAKPPEEWNEEEDGEFTAPLIPNPLCKEASGCGPYMPMIRNPKYKGKWKPPLIDNPKYVGEWKPRNIPNPAYFEDNSPSNFETIIGVGFELWTMQSDILFDNIYIGHSVEEAEQFAKTTFQVKYEYERKQEKGITPEPEVVLDDVAKESYFDVAVKKVTTFVDLVKTSPVSAFKQMPGTASTIGVVFVTFIALLFGLVTLVSSGHTSAGSEKVEDDHSKSDETLKDDLSDGARDSSEQVTSKKRTTRRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRV0</accession>
    <name>M7NRV0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Phosphoribosylaminoimidazole carboxylase</fullName>
            <ecNumber evidence="4 11">4.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_00493</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2</text>
            <dbReference type="Rhea" id="RHEA:10792"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.21" evidence="4 11"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872379.1">
        <property type="nucleotide sequence ID" value="XM_007874188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRV0"/>
    <dbReference type="STRING" id="1069680.M7NRV0"/>
    <dbReference type="GeneID" id="19894191"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00493"/>
    <dbReference type="eggNOG" id="KOG2835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011534_2_1_1"/>
    <dbReference type="OMA" id="ITFDHEH"/>
    <dbReference type="OrthoDB" id="15425at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000037">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016301">
        <property type="entry name" value="Ade2_fungi/plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054350">
        <property type="entry name" value="PurT/PurK_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004679">
        <property type="entry name" value="PRK06019.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609:SF5">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609">
        <property type="entry name" value="PURINE BIOSYNTHESIS PROTEIN 6/7, PUR6/7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22660">
        <property type="entry name" value="RS_preATP-grasp-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001340">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52255">
        <property type="entry name" value="N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="110"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR11478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="584" mass="64370" checksum="A65A496B4B371DE8" modified="2013-05-29" version="1">MDGRIIGILGGGQLGRMLVEAAQRLNIETIVLDPDVDSPAKQINSSKKHINGSFSDFDSIMSLANKCDVLTIEIEHVNVKALENISLEGRVKVYPSFTTIKIIQDKYLQKLHLIKYGNPVVENIAVNSTLEDIRLAGEKLGYPFMLKARTMAYDGRGNYKVDCLESCNSSLAAFEKVSLYAERWVSFEKELAVIVVRNEDGVIGSYPVVETVQSDNICRFVYAPARVPSSVSENAKRIAEKCVQCFSGAGVFGVEMFLTESGDIIINEIAPRPHNSGHYTIDACPTSQYESHIRSILNLPFSKDSFIFSTPETSAIMLNLIANGSKIEYMEICKRALKVEGSIIHLYGKKEPRKGRKMGHITIVAASMSEAENKLYKIFPFSEISSSSCLLTKELFSFRKPLVAIIMGSDSDLPIMKSAIEIFKKFDVPIMGPDIVSAHRTPRKLMEFSCNAAFNGYKVIIAGAGGAAHLPGMVASMTTLPVIGVPIKGSALNGVDSLYSIVQMPRGIPVATVAIGNSTNAALLALRIIGTVDNRVKFLLDEYARNMEADVLLKSKKLQDVGWEHVSLYYIYILDKLMFDLYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRX9</accession>
    <name>M7NRX9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Peptidylprolyl isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_02037</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 18">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874017.1">
        <property type="nucleotide sequence ID" value="XM_007875826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRX9"/>
    <dbReference type="STRING" id="1069680.M7NRX9"/>
    <dbReference type="GeneID" id="19895731"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02037"/>
    <dbReference type="eggNOG" id="KOG0883">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_7_0_1"/>
    <dbReference type="OMA" id="NFIKHCA"/>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01923">
        <property type="entry name" value="cyclophilin_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16663">
        <property type="entry name" value="RING-Ubox_PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000079">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000014">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase cyp65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026951">
        <property type="entry name" value="PPIL2_U-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN-PROTEIN LIGASE PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04641">
        <property type="entry name" value="Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="14">
        <location>
            <begin position="38"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="13">
        <location>
            <begin position="307"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR09856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="62697" checksum="1861145F825E0EEA" modified="2013-05-29" version="1">MGKNTDKLYVTHSEWSGIDGQYSTSTGITKRKIDQPFYKLSFQYCNLSLQPFENPVCYINEANEAFIFELLHIIPYIKKHKKNPITGERLEAKSLLKLNFHKNEDGEYCCPITYKIFNNHSHIVAIKTSGNVFSWDAVNNLNIKAKNMKELLTNEPFTRNDIITIQDPHNFQTHEISKLEGLNKTEDFIVKIQEGTNKELESNISSTKKNITNSKSTFNNEPTMNLVIQNKRNDLSDTKDLKDNPKYSKQKEKHSYNVAPYTTGLAAASFTSTSLTPITSLERALYTDEEYMLIPKRIKTKGYARIQTNLGNINIELNAEWAPKAVYNFIMLAKRGDYKNVIFHRNIKNFMIQGGDPTGTGRGGKSFWEKDFNDEIQGPLSHNQRGILSMANRGKNTNSSQFFITYKETRHLDRKHTIFGKVVGGMETLEKMENSPVDSFDKPISDIIMTDVIIFVDPFEEFKKIQLLNEQKQKNTNSTENDDTTWTGKFLTTNKDIHKSSIIGKYLKQNNISNKIDERIIEINNKPEISEPKKKKRGFGNFDNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NS10</accession>
    <name>M7NS10_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein BOI2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01657</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873618.1">
        <property type="nucleotide sequence ID" value="XM_007875427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NS10"/>
    <dbReference type="STRING" id="1069680.M7NS10"/>
    <dbReference type="GeneID" id="19895351"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01657"/>
    <dbReference type="eggNOG" id="ENOG502QPMX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_376528_0_0_1"/>
    <dbReference type="OMA" id="FGDGWWE"/>
    <dbReference type="OrthoDB" id="73680at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001881">
        <property type="term" value="P:receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09535">
        <property type="entry name" value="SAM_BOI-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045188">
        <property type="entry name" value="Boi1/Boi2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902:SF27">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902">
        <property type="entry name" value="SESQUIPEDALIAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="3"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="7">
        <location>
            <begin position="125"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="447"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="591"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="619"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="591"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="658" mass="75009" checksum="B83511C37DFFC671" modified="2013-05-29" version="1">MKSLENLVFALHDFEAVSPEDLPLKRGEQIFVLKKDEGFNDGWWEGQNMEGRKGLFPVIYTMSYSELVKVLLFDPLSPKTPVETTKEVDLMKTTISNIDDLLSYIDRSGFKNMSLEDSSVDVLSWTPQEVASWIESKGFGSVADKFIEHEITGDILIQMDYSHLKELDILSFGKRFEIEREIKLLRDSLSITTEKQINERILKDDTRSSQSMITARNFQSEKSDYAQSMHSINSASVKRRSYENSFLHMNNVSIDHSYRSSRNGIPLDGIGGAVSKHSLDQSASIYDHKIEMPNASECSESLKLHSRDTEVTVNNKSSWKVTNKLIRAYKRKSKPYVMVGRLQKIDKGFDYKKAARLSKHVNQDVLKACPYGNYRQMDTITMLKEIQSYNTASSKTFKVEKDALKVPLKKPSKVSIAKKSLLKRDQKVPTAIKEGIRHISVHDAIKEADHYGWMRKKTERYGQWKLRFFCLTGTRLSYFYSEDDVGEKGLIDINSYRVVSVNSRFFYGERKFCFKIIPPVPGTAKGINFTSPKVHYFATDTLEEMKEWVRALIKITIGRDNSVPVLSSCKVPTISLKAAKEKISANILMNDKSEPESLSENHSKRTSYQEHAISSGLTKSYHAENALEDPNPTENSSFISDIKSAWENVEILANSTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7NS40</accession>
    <name>M7NS40_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Major surface glycoprotein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10097.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873311.2">
        <property type="nucleotide sequence ID" value="XM_007875120.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NS40"/>
    <dbReference type="STRING" id="1069680.M7NS40"/>
    <dbReference type="GeneID" id="19895074"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01377"/>
    <dbReference type="HOGENOM" id="CLU_441870_0_0_1"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021041">
        <property type="entry name" value="Maj_surf_glycoprot_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003330">
        <property type="entry name" value="MSG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02349">
        <property type="entry name" value="MSG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12373">
        <property type="entry name" value="Msg2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Major surface glycoprotein 2 C-terminal" evidence="2">
        <location>
            <begin position="907"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="760"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1072"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="861"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1080"/>
            <end position="1100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10097.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1123" mass="125581" checksum="776F5239E373321B" modified="2016-03-16" version="2">MAQPVKRQAAGQAAGNDEIKEEQVLGLIVKSYYSDDNKCKANLKQYCEELKKIDGKLESVDVKVKGLCENGKEGEKCKELKKKLETELGAFKTEVENALNNLTDEKCRKYEEKCLLLEEADPNNLEEKCVKLRDRCYRQRRQGVAKEILLRALEGKVNNKDECKKRMKEICQGLSEYSDELVFSCFNSDKTCEYLQKNHGDSCKPLEKELEDKELVEKCQEYLEKCYFYGSSCKDTKCDKVKNKCKGKGIEYEGPKLDFSPVREKPRFPEKIEVENLYKKEEAKGIIVGKPKYKTLRDLALLLIKERNGKDEGEKCKKALEDCESFKHLDYGLEELCGDKDKDNKCKELVEVEDRCTNFKLELYIKGLSTKFEDIESDYFSWGQVSKSVSREDCIKFESECFHLEGVCTNKIGKACENVRVACYKKGQDRVLNRYFQEGLKGLIGDLELVTENLEKCQKSVVGNYTKLKEDRRYFTKCHRPTELCYELLDDVILQSEELEVVLNLRRDFPRKEDCVELKKKCKDLESDSYLNHEKCNTLNRRCEYLKVTEELRKRLLKRGDDALRTQGNCTAVLKKECEELSRRGKEDFSVSCALREETCSFMVEQTENECLFLKNNMDIGKIIEKIENGKRNETLVEELCTLFDPYCHQYIENCPDRLKKTNNAGRKGVCLELEEKCKPFFEKLKLENELTHKLKGSLSDETKCKETLGKHCTEWKKEGNQTLNSLCEDAKKEELCKKLVKKVKEKCPTLKNKLDNEKDELEKKKDEYEKAKQESEKFAKEAKLVLSRPEQDGQGGGSKAQDGSVPKPVGPPVQPPAPAQPTPGGVPVPAPTLAPPAQPTSGGAPLPVPPAAPGGTPGGAPVPVPPPAPGTPPAGPAGPSGPSGGTPAGPPAPGGSTPSGTTNTSNVILVRRTFVSGEVSEPEKKAFVATARALELYLELKEKCKGLQGDCGFRKDCPGCEAACKEIDKLCEGIEGLKVTPHHTVISTATQTTTTTATTTTTTTTTTTTTTTTTTTATTTESVDGGKVTEECTLVQTTDTWVTSTSLHTSTLTSTSTVTSTVTLTSMRKCKPTRCTSDSSKETETQKEEEKEEEVKPNEGMKIRVPEMIKIMLLGVIVMGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NS63</accession>
    <name>M7NS63_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">37S ribosomal protein S25, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01396</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873331.1">
        <property type="nucleotide sequence ID" value="XM_007875140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NS63"/>
    <dbReference type="STRING" id="1069680.M7NS63"/>
    <dbReference type="GeneID" id="19895093"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01396"/>
    <dbReference type="eggNOG" id="ENOG502RZQQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081350_0_0_1"/>
    <dbReference type="OMA" id="WELARPQ"/>
    <dbReference type="OrthoDB" id="5542239at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23701">
        <property type="entry name" value="At1g26750"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059242">
        <property type="entry name" value="mS23_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016939">
        <property type="entry name" value="Ribosomal_mS23_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13741">
        <property type="entry name" value="MRP-S25"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="212" mass="25559" checksum="6394F330F297D823" modified="2013-05-29" version="1">MPIDLRPLQIHILTSKLLQINYIKKEPKWFRPIVEAPPSFNLLRRLPPQFLKIKKSLKPKLLRPQNIEYPEDQLRRRFFKDHPWELARPRNLIEYNEKNTEHYDWSQLHQKAKPLDGESVVQRQFWLMTYAKPKRTEENAYTEALSEFYVARAQEQILQIVSEDEAKMHGAKFDKSHIEIGIILEQNILKIWRKKATLQSYLQKKRYNNINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSH9</accession>
    <name>M7NSH9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM5</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_01489</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873429.1">
        <property type="nucleotide sequence ID" value="XM_007875238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSH9"/>
    <dbReference type="STRING" id="1069680.M7NSH9"/>
    <dbReference type="GeneID" id="19895185"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01489"/>
    <dbReference type="eggNOG" id="KOG0481">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000995_7_2_1"/>
    <dbReference type="OMA" id="ITYCKTR"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006267">
        <property type="term" value="P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030174">
        <property type="term" value="P:regulation of DNA-templated DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17756">
        <property type="entry name" value="MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000241">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008048">
        <property type="entry name" value="MCM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054125">
        <property type="entry name" value="MCM5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF42">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21933">
        <property type="entry name" value="MCM5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01661">
        <property type="entry name" value="MCMPROTEIN5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="320"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR10217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="719" mass="80734" checksum="F2FAA6F3A7DF4B95" modified="2013-05-29" version="1">MSVIGWDQPSVYSTSVLSGEIQPNAPKELEKQFKDFIQEFILNNSYIYRDQLRDNILVKQFYLNVNVAHLISFNEELAHKLTSNPADMLPLFEMAVKDSAKQIIYSGSDSKKEFPDCQVTLYSDANYTLIRDLNASYISKLVRIPGIVIGASTLSSKATRLHIMCRTCRNIKIISVNGGFSNIQLPRTCDNPATHGEKKECPLDPYIIIHEKSSFIDQQVLKFQEAPNMVPVGELPRHILLSIDRYLTNKVTPGSRCTVIGIYSIYQNKSFKTSNAVAIRNPYVRVVGLQAEIHGNSKSSFIFTEEEEEEFLTLSRNPNLYEIFANSIGSSIYGNIDIKKAICCLLFGGSKKILPDGMRLRGDINILLLGDPGTAKSQLLKFVEKVAPIAIYTSGKGSSAAGLTASIQRDAASREFYLEGGAMVLADSGVVCIDEFDKMRDEDRVAIHEAMEQQTISIAKAGITTILNSRTSVLAAANPVFGRYDDIKSPADNIDFQTTILSRFDMIFIVKDEHNENRDKTIAAHVMNIHMNKTVDDNSTREISIEKMKKYISYCKNKCAPRLTPEAAEKLSSHFVAIRKQVRQVEQNSNERSSIPITIRQLESIIRISEALAKIRLSTVATEEHVDEAIRLFMKSTMDAVGEGQITRQELVEEVHKIESELRKRLPIGWSTSYATLTREFINGKGYSLYALQKALYIMERRETIQLRNQGASVYRIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSM4</accession>
    <name>M7NSM4_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01519</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat MORG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873462.1">
        <property type="nucleotide sequence ID" value="XM_007875271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSM4"/>
    <dbReference type="STRING" id="1069680.M7NSM4"/>
    <dbReference type="GeneID" id="19895214"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01519"/>
    <dbReference type="eggNOG" id="KOG0316">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_1_1"/>
    <dbReference type="OMA" id="MCWDIRT"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051980">
        <property type="entry name" value="WD_repeat_MORG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842:SF3">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING PROTEIN 83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="55"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="270"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="304" mass="33536" checksum="A5BD0E6FC029F87E" modified="2013-05-29" version="1">MLTFPTQKVHVLSPAGKFPANVILYNTKGQYALTGSHDRFVRLWNPHTGGLIQEYRAHGYEVLDITVSCDSTKFASSGGDKQVFLWDVTAGRTIQRFSGHFSRVNTVSFNLEATVLASGSYDSSVRLWDCRSLSHTPIQVLEDGKDSISSVLIANHEIITGSIDGRVRTYDLRRGQLYTDVIGQPVTSVEQSNDANCLLISTLDSTIRLLDKCNGGLLQTFKGHVNSEYRVKSCFGQSDKVVISGSEDGRICVWDLLEAKLIHQLRFAPENSQRSCVSCVAFHPKKNQMLSCGVNGEITVWGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSU2</accession>
    <name>M7NSU2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pre-rRNA-processing protein Ipi1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873395.1">
        <property type="nucleotide sequence ID" value="XM_007875204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSU2"/>
    <dbReference type="STRING" id="1069680.M7NSU2"/>
    <dbReference type="GeneID" id="19895152"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01455"/>
    <dbReference type="eggNOG" id="KOG2149">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_950358_0_0_1"/>
    <dbReference type="OrthoDB" id="361362at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024679">
        <property type="entry name" value="Ipi1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12333">
        <property type="entry name" value="Ipi1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein Ipi1 N-terminal" evidence="1">
        <location>
            <begin position="26"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="293" mass="34673" checksum="1991982F812C524E" modified="2013-05-29" version="1">MIDEESDVRRALQSLLSSIFTEKAELIEPHVIFMILYIHSAMTHILPDVRNDSTKILIWLLEIQGEYVVKYAWEKFLNTFSVLFGWKSDENIKNTNTYLFKSTFSQESRYQHFKAFDIFLRKGLCFDKENSHVAPKIYLNQTRYLSGINHPMVSRYLGWPLKSSPYFHLSLFSQVNNISKKVYKDVWSRSMLFYLYLPGLLSYLQGTWFELLPSSMDSLSFITIKTCIHVISILDHINLVLKKIEVDELSLKQNLKTLHGFITRIEFTMKELKNYNESVELRKYWIKTGLYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M7NT83</accession>
    <name>M7NT83_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873486.1">
        <property type="nucleotide sequence ID" value="XM_007875295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NT83"/>
    <dbReference type="GeneID" id="19895235"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01540"/>
    <dbReference type="HOGENOM" id="CLU_1050204_0_0_1"/>
    <dbReference type="OrthoDB" id="5335762at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035187">
        <property type="entry name" value="Mpm1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17234">
        <property type="entry name" value="MPM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="265" mass="31547" checksum="9E73B6A790EFE166" modified="2013-05-29" version="1">MEEKEIMPGIFKISSYFKKLWKKKTALILSSFFGVPFVLPSASRSAFILMDDTLPCSTDKQEKASENARRDPERCFYMERDPYFGRSLWFHPVFDFIFPGWGFYTIPSFFRWFFREHGVLDRNERETRDFERYRDFLWRPRLFHDEIWKDAFETFEELRTKEIDNEEVFENKNEYKKGKESSWDESSKKVTSTFSKKMLRTFGDGSYETIEIIKRCFDDGTCETTKYTDSSNGKYAKKGEILDNKVQSPTSTCTEESAFHPAIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTG4</accession>
    <name>M7NTG4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein ARV</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01277</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Regulates also the sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ARV1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873201.1">
        <property type="nucleotide sequence ID" value="XM_007875010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTG4"/>
    <dbReference type="STRING" id="1069680.M7NTG4"/>
    <dbReference type="GeneID" id="19894974"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01277"/>
    <dbReference type="eggNOG" id="KOG3134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1338119_0_0_1"/>
    <dbReference type="OrthoDB" id="2192830at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097036">
        <property type="term" value="P:regulation of plasma membrane sterol distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007290">
        <property type="entry name" value="Arv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467">
        <property type="entry name" value="ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467:SF0">
        <property type="entry name" value="PROTEIN ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04161">
        <property type="entry name" value="Arv1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR10572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="167" mass="19598" checksum="A6F6FAA2163274B9" modified="2013-05-29" version="1">MLLCVECAHPVTSLYTEYSKNNFRLTQCPLCKEFADKYVEFDYVIITIDLMLIKPQVYRHLLFNQLGTQDNHFNPYIVRFWLLLILFDVYLMWLRADRQSEQSISTSTSSQAILSGIAKCLYFLIICLLETISFHWGPRILARQWLGWQRKILLYASGTISLTSLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTJ5</accession>
    <name>M7NTJ5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01137</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL1 forms part of the L1 stalk, a mobile element that plays a role in evacuating the exit-site tRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873051.1">
        <property type="nucleotide sequence ID" value="XM_007874860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTJ5"/>
    <dbReference type="STRING" id="1069680.M7NTJ5"/>
    <dbReference type="GeneID" id="19894834"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01137"/>
    <dbReference type="eggNOG" id="KOG1570">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062853_3_0_1"/>
    <dbReference type="OMA" id="GPRNKMP"/>
    <dbReference type="OrthoDB" id="2449818at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000006">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000002">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_uL1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="215" mass="24085" checksum="05E510DCA7EFF57B" modified="2013-05-29" version="1">MSKVSALAIHENVRNLLHASQEHKRGFLETVELQIGLKNYDPQRDKRFSGTVKLPHVPRRLNICLLADAYDLDRAKELGVDALSVDDLKKLNKQKKLVKKLAKKYDAFISSDSLIKQIPRLLGPGLSKVGKFPTPLSHTDDLSTKLTEVEATIKFQLKKVLCLGVAVGNVQLTEDQLVANIMLSINFLVSLLKKAWQNVGSLVIKSTMGRPYRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTV4</accession>
    <name>M7NTV4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GTP-binding protein RHO3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_00853</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872762.1">
        <property type="nucleotide sequence ID" value="XM_007874571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTV4"/>
    <dbReference type="STRING" id="1069680.M7NTV4"/>
    <dbReference type="GeneID" id="19894551"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00853"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_21_2_1"/>
    <dbReference type="OMA" id="THTIMLC"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005933">
        <property type="term" value="C:cellular bud"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045921">
        <property type="term" value="P:positive regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090338">
        <property type="term" value="P:positive regulation of formin-nucleated actin cable assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010590">
        <property type="term" value="P:regulation of septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000780">
        <property type="entry name" value="Rho GTPase Rho3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR10702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="203" mass="22999" checksum="DE48572B3E4A6D71" modified="2013-05-29" version="1">MVFCLSSPKALHRKIVILGDGACGKTSLLNVFTRGYFPQIYEPTVFENYVHDIYVDGQQIELSLWDTAGQEEFDRLRSLSYADTHVIMICFSVDSRGSLENVQSKWVAEIASHCEGVKLVLVALKCDLRELEDEIAYNDRGMNDQHRYIQYEEGLSVAKFIRAVRYLGVNEAFTEAARVAIAAKPKGASADDRSYRQRNCDIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7NV92</accession>
    <name>M7NV92_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone deacetylase complex subunit SAP18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872548.1">
        <property type="nucleotide sequence ID" value="XM_007874357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NV92"/>
    <dbReference type="STRING" id="1069680.M7NV92"/>
    <dbReference type="GeneID" id="19894348"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00650"/>
    <dbReference type="eggNOG" id="KOG3391">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064128_0_0_1"/>
    <dbReference type="OMA" id="TYRMREI"/>
    <dbReference type="OrthoDB" id="440566at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.550">
        <property type="entry name" value="ASAP complex, SAP18 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010516">
        <property type="entry name" value="SAP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042534">
        <property type="entry name" value="SAP18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082:SF0">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06487">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR11051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="21600" checksum="20F7B0AF0D94CB59" modified="2013-05-29" version="1">MYISKPSKPIDRQKTTPFLLRIFCKIGGFHSIEEFQPESQPVADEVQIYTWKDASLYELAQLLAKAIPNNNSTRFSFRLIYNDNYKEKYLTKDIGHVLLFSRGLEANKTLDDVRFVIGDWIDVAINNDEGPKTRTLNRGFGRGRTNTLTKGRNHPYPDLPPGRDWRKRDTDGNHGRGRLEPYKGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVR7</accession>
    <name>M7NVR7_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872293.1">
        <property type="nucleotide sequence ID" value="XM_007874102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVR7"/>
    <dbReference type="STRING" id="1069680.M7NVR7"/>
    <dbReference type="GeneID" id="19894114"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00416"/>
    <dbReference type="eggNOG" id="ENOG502S64Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054960_0_0_1"/>
    <dbReference type="OMA" id="KTTKWAG"/>
    <dbReference type="OrthoDB" id="5583277at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053065">
        <property type="entry name" value="Archenteron_Induction-Rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024382">
        <property type="entry name" value="Vps3844_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049205">
        <property type="entry name" value="Vps3844_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36853:SF1">
        <property type="entry name" value="DUF3844 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36853">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21656">
        <property type="entry name" value="DUF6859"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12955">
        <property type="entry name" value="Vps3844_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar sorting protein Vps3844 N-terminal" evidence="2">
        <location>
            <begin position="21"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar sorting protein Vps3844 C-terminal" evidence="1">
        <location>
            <begin position="292"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR11392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="367" mass="42487" checksum="34AB7FF73B5486A5" modified="2013-05-29" version="1">MVYKILPHKYSEIHSSQYPDSLTPEEARQVLAHMLGVSRFHKLGFQGQSTKILDKKEMLNEENLWKETENHMIITLAGVIDYKMFYKQHPLFTIENSPSSEAYNYLIKRFLNQLNELTGLTIERLYANMYGGGLFLIPPILGIHDYIQHAPSLEMFENIFDKKFTGIFNLQYKEDRCFLSEILSLNSFINALSNSSELSTNRLISAYLANLEVLYHQYGIYSKQYTAATEAASLILGQISKKMPNTTFIVLLLPPKPIIKNTLLRRAEIQNVFGDDHSAPALKGFRNIYPHCFSSKADCEKLTNYCSNHGNCEKYLEQEKCYTCRCFPTFTNATGNGKKVFYWSGSLCQKRDISFEFQMFFWVHFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVY4</accession>
    <name>M7NVY4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_00487</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872373.1">
        <property type="nucleotide sequence ID" value="XM_007874182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVY4"/>
    <dbReference type="STRING" id="1069680.M7NVY4"/>
    <dbReference type="GeneID" id="19894185"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00487"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_767513_0_0_1"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001156">
        <property type="entry name" value="Zinc finger protein 407"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF66">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR11472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="361" mass="40756" checksum="9DFDBFDD49CD7D1B" modified="2013-05-29" version="1">MNLIRSPKGSKTLFHVSLPQDDGKVCSEIRSLQSSPNISSIIKDGVESSKLIDQTSSSQGQQLDHSSKLFDIQRPFSPSHFFSQHGNSFITRLQSEEMCDSQSLSSSNSGIPNLVGYWPVAPLQTGSRSDSHVFQQHPYLVFQQQLLSPLNTRFEHSYSPQATTHFPLSVYSSYLSQRNLDSSFGMNRQPQPADKFPSLPFSTSPLYQLHDNNLANYHSYLQFPSLHNTYPPMGSISYSSGEYSNYYINNQPVFSDLTSGNDITSQSYTQFLSRNHSFPPSKQSKSAEYLPSARSIKTGNSFSNRPFKCDQCFQSFNRNHDLKRHKRIHLAVKPFPCPSCEKSFSRKDALKRHILVKGCIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NW55</accession>
    <name>M7NW55_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_00547</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872438.1">
        <property type="nucleotide sequence ID" value="XM_007874247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NW55"/>
    <dbReference type="STRING" id="1069680.M7NW55"/>
    <dbReference type="GeneID" id="19894245"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00547"/>
    <dbReference type="eggNOG" id="KOG2286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011776_2_0_1"/>
    <dbReference type="OMA" id="MNIGPKT"/>
    <dbReference type="OrthoDB" id="190098at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051601">
        <property type="term" value="P:exocyst localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.50:FF:000006">
        <property type="entry name" value="Exocyst complex component sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.70">
        <property type="entry name" value="Exocyst complex component Sec6, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010326">
        <property type="entry name" value="EXOC3/Sec6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042532">
        <property type="entry name" value="EXOC3/Sec6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06046">
        <property type="entry name" value="Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="217"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR11537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="740" mass="87722" checksum="6EB1EFE2CB920CBF" modified="2013-05-29" version="1">MEEPLDSAIKCIEELLRQPDDLYKLDNLITQFSRKKSSVDAQIKAIIKDQLSIIRSGLAFLSSTQQHMYSIKDNMFKIDKLFSESRMIEKFSIIDNASKIYKNFNDVQKMTENLRNIPKELDKIDTMMKQDEEDETLRMQNFLNIHYKLVQLQNFRDQAMYQSRNAGQDVQRILERYFSRLNSISKLFENMLWILTQDILKIVRNGNHDLVIRLAKVIDTEDRLDREFSEIEKLKENNRELACRLKTIHDSPRILRNYKERFFEEIKISIDINLKEFQERFKFDYSGILENIFWIFDDLHLVNQEITNLVPLKWNIFEVFLNFYHAGIYDILKNIMYDEPDAKTILKVLEFVKKYYLKMNKELGVTRDKLIPRLLDGKESEIVDDYLRLIVKKMKEWVSNLSKKEFNSFIRREEQPEVDTDNLYGMPGAVIMFQMISQQMDVAAESNQSRVLLGVVLECSKILQQHREAWGDLLHSEVIKQIEQPNDIPGGLVEYIIALANDQIRCADYTEAISARILPWVSEKYKLEISECLSKTTDGFLDLSHKCIISLLKLICNDLKSAFLFFFTPVWYGGNHMSLIMDTYKEYLDDCRSHLNENLFGILVEDLLTEFLVLYLSCVRNKGCRFKMPNCIEQIKNDVRLAFGLFARYINPKELEYHFNVIERMLTLLSTTRTLFFQDYMAFKHDYWDLPFWYVEDLLTKRDDLDKSTVKEMLETIKREEVQTNEVHNNNITIMSKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWM3</accession>
    <name>M7NWM3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome c oxidase copper chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00123</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871982.1">
        <property type="nucleotide sequence ID" value="XM_007873791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWM3"/>
    <dbReference type="STRING" id="1069680.M7NWM3"/>
    <dbReference type="GeneID" id="19893821"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00123"/>
    <dbReference type="HOGENOM" id="CLU_149618_1_3_1"/>
    <dbReference type="OrthoDB" id="1915887at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007745">
        <property type="entry name" value="Cyt_c_oxidase_Cu-chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05051">
        <property type="entry name" value="COX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 8" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR607745-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="59" mass="6792" checksum="B3525DE742128361" modified="2013-05-29" version="1">MAEIKKKSDISEEKPKPCCVCLETRKARDDCMVSKEGDPLIICQELIEAHRQYVLIWIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWU8</accession>
    <name>M7NWU8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TECPR1-like DysF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871926.1">
        <property type="nucleotide sequence ID" value="XM_007873735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWU8"/>
    <dbReference type="STRING" id="1069680.M7NWU8"/>
    <dbReference type="GeneID" id="19893768"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00070"/>
    <dbReference type="eggNOG" id="ENOG502QQTF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_711991_0_0_1"/>
    <dbReference type="OMA" id="HITILQF"/>
    <dbReference type="OrthoDB" id="74314at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052816">
        <property type="entry name" value="Peroxisomal_Membrane_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="TECPR1-like DysF" evidence="6">
        <location>
            <begin position="49"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="388" mass="45034" checksum="D0C37F4B356A8B3E" modified="2013-05-29" version="1">MADKQLKQSVTVQDVFISAITSSLASSSPKGDLNSSQIPFDDDDSSVAPFSLHILTQNFKKISSRIGILFQARDKLASIFQWENPYKTLSFLCIYTLISINPSLILMIPSTIFIFGLLLPSYEARYPDSYSDIFSLNNKDIITSKKSNTNGKPSEAKDFTINIRNIQNSMSEYTHFYDLIYGFLLKYTSFNDDKLSSTVFLFCIIISVFLILFSHWIPLRLIFLLFGWISVLSINTDVQKAIKALIEEYKKNRLQLESDLFFNYDYIYNWIDYNYIAPEIPKKTIFVEIFEFELKTDQKNEKLIYYSSNPYALPPNKTSTPAEEGLRELLYDDSSITGSINCIHPPEGYKFEKNSFWKVDDNNTENLSINLNHKDWRRRRLRREVVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NX19</accession>
    <name>M7NX19_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="5 18">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 18">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PNEG_00256</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="17 18">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18 19">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="5 18"/>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872127.1">
        <property type="nucleotide sequence ID" value="XM_007873936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NX19"/>
    <dbReference type="STRING" id="1069680.M7NX19"/>
    <dbReference type="GeneID" id="19893954"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00256"/>
    <dbReference type="eggNOG" id="ENOG502QPJG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049944_5_0_1"/>
    <dbReference type="OMA" id="HGCGMIS"/>
    <dbReference type="OrthoDB" id="448573at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000022">
        <property type="entry name" value="CDP-diacylglycerol--serine O-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016271">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF61">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000852">
        <property type="entry name" value="Phosphatidylserine_synth_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 18 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 18" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR000852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EMR11832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="229" mass="25843" checksum="F9AA08C195D8F4BD" modified="2013-05-29" version="1">MPKNKTPILNKTEKKSSTNIYDDKHFSLIRTLQLADFITELNGFCGIMSVFSSMKYCLGDPLDTTWLWKSMTLMPLGLCFDFLDGRVARWRKKSSPMGRELDSLADLVSFGIAPSVFAFALGIRTLIDSIILSFFVLCGISRLARFNISVDSLPKNKYGKLKYFEGTPIPTTLSIVAMMAWWVRSGWILEKLPFGVIYKNSFFEFHPAAIVFALSGCAMCSKTLKVRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7P2C5</accession>
    <name>M7P2C5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_03478</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion inner membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875567.1">
        <property type="nucleotide sequence ID" value="XM_007877376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P2C5"/>
    <dbReference type="STRING" id="1069680.M7P2C5"/>
    <dbReference type="GeneID" id="19897165"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03478"/>
    <dbReference type="eggNOG" id="KOG3489">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IFFDINT"/>
    <dbReference type="OrthoDB" id="344165at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0811">Translocation</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="7">
        <location>
            <begin position="52"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="118" mass="14256" checksum="96D204836A8F840F" modified="2013-05-29" version="1">MTDTLKLLESLDNKSRDELSQFIEQENGKAKIQQGFFHIFLNKIKKLYKGILEFTDRCFKRCITNKLGNNLDRTEETCLQNCVDRWLDVNIHLIKYLENFKKRNIKINFVNIYRIFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7P320</accession>
    <name>M7P320_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_03403</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12 13">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875488.1">
        <property type="nucleotide sequence ID" value="XM_007877297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P320"/>
    <dbReference type="STRING" id="1069680.M7P320"/>
    <dbReference type="GeneID" id="19897090"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03403"/>
    <dbReference type="eggNOG" id="KOG1868">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005922_2_0_1"/>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015063">
        <property type="entry name" value="USP8_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF95">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08969">
        <property type="entry name" value="USP8_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140856">
        <property type="entry name" value="USP8 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="640"/>
            <end position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="991" mass="115318" checksum="59AA436F141FE7DF" modified="2013-05-29" version="1">MGTENEEPGPGDTLEILKKKAAIFEKGVNYPIKLWISTARKLYDQAFKYENESRLEIAYVKYLRASSIVIEVIPSHKDYVLFKSQGGPILKQYQELRQETSLSFFRFQKIHQILKLRDIEKMSLNKSNTVVNTKESFLRSSSKSVSPELIQRDLKPGLSYSFSLNEKIDFPKNDHMEISDIRRSQSIDLLNSQFRLPTPISFPFKFSPTNTDLKLSFSETNIDKDMNPFTSSSLLTDLNKKHVLSDQITIFPNFSFIDSDTLYKYIISKDNKSRILFLDIRPRSEFNKFRIASENIVCIEPIILTLQEDISGDQLEDSLIISPLSEQKTFSNRHKFDLIVYYDWDSKNDNLSGNISQNEKARIFYNLNKAIYNYGGFQKPLKHIPVLLSGGLKEWVNFIKKNDIFCDFIEGTNTHNIRNGFTENILPSDHESNYLYLKSNINIPNSYAPSDYSLYSVDIGLEKKNHKNSIEMTMSMEKFQSLFKNNMNLTDNKDISSGSNNDLHLKMKEKYPSHLTLSQQSLIKFMPYFETNDIHNSLRDYHNINKYEFLSQKMDINDLNNCEKKGISSNNPFYDFIEPKNTNNEFPRRSTSREYNSLDSYKFKQPSLSDINSIITKPQTLTSQIYNTEQFCVRGIIGATGLTNLGNTCYMNAIIQCLNSTIPFVRYYRDGSYKKHINFNNPLGYKGELVQTFARLITYLWDNEHTYVSPLFFKNVVGRLKEQFRDNDQQDSQEFLAFLLDGLHEELNIAAGQLRPKELTPEEELKIENMPDKIASNIEWQKYVRLNNSIVVSLFQGQLQSRLKCLTCDFQSTTYNPFTYLSLPIPLTQAKTSTLYECLQFFVQKEYLKDKEQWYCSKCRKPRDATKTLTISKIPQILLIHLKRFQTCGHWKDKINTKIDFLINNFDLTDFLLDSTQSLSDPLNHGQYLYHLYAVTNHYGNLDGGHYTAMVKNSFTNSWNLFDDRRVVFCSERDVVSPAAYILFYIRNNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3D9</accession>
    <name>M7P3D9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,3-beta-glucan synthase</fullName>
            <ecNumber evidence="3">2.4.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,3-beta-D-glucan-UDP glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_03180</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-beta-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21476"/>
            <dbReference type="Rhea" id="RHEA-COMP:11146"/>
            <dbReference type="Rhea" id="RHEA-COMP:14303"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.34"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.34" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875243.1">
        <property type="nucleotide sequence ID" value="XM_007877052.1"/>
    </dbReference>
    <dbReference type="SMR" id="M7P3D9"/>
    <dbReference type="STRING" id="1069680.M7P3D9"/>
    <dbReference type="GeneID" id="19896867"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03180"/>
    <dbReference type="eggNOG" id="KOG0916">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000844_0_1_1"/>
    <dbReference type="OMA" id="AWTDFFI"/>
    <dbReference type="OrthoDB" id="1880850at2759"/>
    <dbReference type="BRENDA" id="2.4.1.34">
        <property type="organism ID" value="10172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000148">
        <property type="term" value="C:1,3-beta-D-glucan synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003843">
        <property type="term" value="F:1,3-beta-D-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
        <property type="term" value="P:(1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051278">
        <property type="term" value="P:fungal-type cell wall polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026899">
        <property type="entry name" value="FKS1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056261">
        <property type="entry name" value="FKS1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003440">
        <property type="entry name" value="Glyco_trans_48_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF48">
        <property type="entry name" value="1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14288">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23605">
        <property type="entry name" value="FKS1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02364">
        <property type="entry name" value="Glucan_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01205">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="564"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="607"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="645"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="695"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="769"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1376"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1432"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1519"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1545"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1635"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1678"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1717"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1816"/>
            <end position="1842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1879"/>
            <end position="1899"/>
        </location>
    </feature>
    <feature type="domain" description="1,3-beta-glucan synthase component FKS1-like" evidence="13">
        <location>
            <begin position="374"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR08340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1948" mass="224477" checksum="FB432844EC036648" modified="2013-05-29" version="1">MSQQQHYYDESYPGQNGPYYGEHGYGNSGFNNGSYASGVYDEQGEYYAPEYGQEYYDEYDSGGVMYDGQGREMYNGGEDGYYRQEDRYYDYPQDAYIADTYDPYGVPMADQRPLQYFEGQDEYHMYDRKGKRRGSSEGSETFSDFTMRSDMARAAEFDSYGRFDERYRSYGPSTESLNQMASRQRGYRPDSQISYTGNRSSGASTPIYGMYYNQAAMMTSARSREPYPAWTAENQIPVSKEEIEDIFIDLTNKFGFQRDSMRNMYDHMMVLLDSRASRMTPNQALLSLHADYIGGDNANYRNWYFAAQFDLDDAVGFSNMDLGKNRKSSYSQKSSKKFQKNSASKNILQALDGDNSLESAIYRWKTRCTQMSQYDRARELALYLLCWGEANQVRFTPECLCFIFKCANDYLNSPQCQAMVEPAPEGSYLNDVITPLYTYMRDQGYEIINGRYVRRERDHNKIIGYDDINQLFWYPEGIERIVLSDKTRMVDLPLDQRYPRFKDVVWKKAFFKTYRETRSWFHLFTNFNRIWIIHITVYWFYTAANSPTVYTHNYQQSLDNQPPFAYRMSAVGFGGGVASLLMIIATLAEWAYVPRRWPGAQHLTRRLLFLILFLIINVAPGVYVIKFAQWKPNVSVVTTLISIMHFLIAIFTFLFFAIMPLGGLFGNYLYKKTRRYVASQTFTANFAKLKGNDLWLSYGLWIAVFACKFAESYFFLSLSLRDPIRYLNTMTIGHCGIRYLGSALCPYQAKITLGIMYITDLVLFFLDTYLWYIIWNTICSVARSFYLGVSIWTPWRNIFSRMPKRIYSKILATNDMEIKYKPKVLISQVWNAVVISMYREHLLAIDHVQKLLYHQVPSEQEGKRTLRAPTFFISQEDHSFKTEFFPSHSEAERRISFFAQSLSTPIPEPLPVDNMPTFTVLVPHYGEKILYSLREIIREDDQLSRVTLLEYLKQLHPVEWDCFVKDTKILAEETSLYNGGVPFDKDEKDTVKSKIDDLPFYCVGFKSSAPEYTLRTRIWASLRSQTLYRTVSGFMNYSRAIKLLYRVENPDVVQMFGGNTDKLEHELERMARRKFKFVISMQRFFKFSKEELENTEFLLRAYPDLQIAYLDEEPPMNEGDEPKIYSSLIDGYSEIMENGKRRPKFRIQLSGNPILGDGKSDNQNHAIIFYRGEYIQLIDANQDNYLEECLKIRSVLAEFEEMTPIEESPYNPNEVSSAANPVAILGAREYIFSENIGVLGDVAAGKEQTFGTLFARTLAQIGGKLHYGHPDFLNGPFMTTRGGVSKAQKGLHLNEDIYAGMTALLRGGRIKHCEYYQCGKGRDLGFGSILNFTTKVGTGMGEQMLSREYYYLGTQLPLDRFLSFYYAHPGFHINNLFIILSVQLLMIVMINLGSMYNILLICRPRRGQPITDPYLPVGCYSLAPVLDWIKRSIISIFIVFFIAFIPLVVQELTERGVWRASTRLAKHFGSLSPLFEVFVSQIYANSLLQNLAFGGARYIGTGRGFATTRIPFSILFSRFAGASIYLGSRTLIMLLFATVTMWIPHLVYFWVSVLALCISPFIFNPHQFSWTDFFVDYREFIRWLSRGNSRSHANSWIGYCRLSRTRITGFKRKALGQPSEKLSGDIPRAGFSNVFFSEVIGPMILVLLSLVPYCFINSRPGFEPFGKSNPAKNGSNPLIRIAIVSFAPICVNAMVAFVFFGMACCMGPILTICCKKFGAVLATISHAIAVIILVTFFEVLWFLEGWSFSKTILGLVTMISLQRAFLKMLTIMILTREFKHDGSNLAWWTGRWYSNNLGVYAMSQPAREFVCKVIELSLFAADFCLGHLLLFILTPILAIPYIDRWHSMLLFWLRPSRQIRPPIFSLKQNKLRKRIVRRYATLFFGLFLLFLMIILVPALGHSKFPKSLNNIAFLKNLGLIQPSNDPRGATGRTTRPGNSNGTYKLFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3V4</accession>
    <name>M7P3V4_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_03026</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in endocytosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YPP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875077.1">
        <property type="nucleotide sequence ID" value="XM_007876886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P3V4"/>
    <dbReference type="STRING" id="1069680.M7P3V4"/>
    <dbReference type="GeneID" id="19896713"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03026"/>
    <dbReference type="eggNOG" id="KOG4162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003276_1_0_1"/>
    <dbReference type="OMA" id="CNGDWQA"/>
    <dbReference type="OrthoDB" id="29013at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23270">
        <property type="entry name" value="YPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051722">
        <property type="entry name" value="Endocytosis_PI4K-reg_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083:SF464">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT DOMAIN 7, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN, TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="869"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="916" mass="106880" checksum="4B3B8C804D7612D7" modified="2013-05-29" version="1">MRSEKAVLYERLLDTALCSHDWSNVPELVRKVRKHDEKKDALCEIVLAEYRLESLMKSEKNEKIEDKILCTVFVDARNMFSVVDEVSISEIMEIVMKFLNSVETQHEKLHARTVLSHIYFLKSDYRRALETISSYCEVTSILESSGYCLFNIIKGYFIKGLCQECMFETSLAIETYKSAVYAIEQIKHNRIPEKAFEWLDFIYYRSCLLFLRSDSYNAIKSGYLDNSISLIKKALYSAAVCRLYYRLLSELLNNSILSDTPKDESSNLKESDLPYCVFSVSELESRILKIEPIYKSLLLQVVNFPKSGRLNGIILEYVDWVMKNWKNMGKGLDYAETIVETIYHAINKTYKSHRLIRYLMEVLIFLRNYDEARCAFDLYVELVERAKISPFRQEIMSRRNEPIEQDTGQDFDDDITVAETYVNGIKLYIIHYDDFEKALAIVKKLRHALDTLESPKHCKVIGDIWEVIGITYSCQSIKTYEASERPSIQQDAINAFQKSLEYVPDKKSTLYHLAFQYAEQREITDAILTIKNVVSQKYMLYQSFHLLSLLLSTRGEYSQAIQICEAAIQISGVETGDNFSHLDYRDRESLVEIKITLCALLEARDGIDVAIEMYKNIFNFYAKVFKTEYSFPVFELSDSIPMETISSLLLTENKVMIKSLEERLSSHVFSQRYTSSQLSLFNASKRSVSFCSLNSNIQDINSKLKHKYSSLDHSDLNVSRISQLSLENGSQSKILSFKQSEFSHYYLKKEQKKISKRCLRKIWLVFSSLYCRASKWDESLMSIKEAEKIGLFHPDVHTQWGIFYYHLNRLEDAARRFEWALLEDHDHINANIGLSKVFLDLKGEKYESYRDRAEQMLDMVTKLSGWDSSEAWLLLGESWEKMNDLKNAKKAYWYAVELEDTRPVRHWRNVSPRFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3Y2</accession>
    <name>M7P3Y2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar proton pump subunit B</fullName>
            <shortName evidence="6">V-ATPase subunit B</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Vacuolar proton pump subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_03047</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Vacuole membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875102.1">
        <property type="nucleotide sequence ID" value="XM_007876911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P3Y2"/>
    <dbReference type="STRING" id="1069680.M7P3Y2"/>
    <dbReference type="GeneID" id="19896734"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03047"/>
    <dbReference type="eggNOG" id="KOG1351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022916_3_0_1"/>
    <dbReference type="OMA" id="EGFKIKP"/>
    <dbReference type="OrthoDB" id="1735853at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18112">
        <property type="entry name" value="ATP-synt_V_A-type_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18118">
        <property type="entry name" value="ATP-synt_V_A-type_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit B, brain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005723">
        <property type="entry name" value="ATPase_V1-cplx_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003235">
        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01040">
        <property type="entry name" value="V-ATPase_V1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF4">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="8">
        <location>
            <begin position="27"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="7">
        <location>
            <begin position="150"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="9">
        <location>
            <begin position="382"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="519" mass="58447" checksum="13D4544872BE2B3A" modified="2013-05-29" version="1">METDFKINSEASKQDYSLYPRISYKTVTSISGPLVVLDQVKFPRYNEIVNLYLENGDVRTGQVLESRGTTAIVQVFEGTASIDVRSTRVEFTGKSLRIPVSEDMQGRIFNGSGKPIDQGPLVIPEDYLDINGSPINPYSRIYPQEMIQTGISAIDTMNSIARGQKLPIFSAAGLPHNEIAAQICRQATLIKPTKDVQDGHEDNFSIVFAAMGVNMETARFFKRDFEENGSLERVTLFLNLASDPTIERIITPRLALTTAEYYAYQTEKHVLVILTDMTSYADALREISAAREEVPGRRGYPGYMYTDLSTIYERAGRVEGRNGSITQIPILTMPNDDITHPIPDLTGYITEGQIFVDRQLHNRQIYPPINVLPSLSRLMKSAIGEGFTRRDHPEVSNQLYANYAMGKDAAAMKAVVGEDAISDEDKLSLEFLEKFEKYFISQGPYESRTIEESLDIGWSLLRIFPREQLTRISEEIIKEFYPRAPAKKKNSEINNSKNNYDNDVTIESAILSQENSNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7P456</accession>
    <name>M7P456_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_03119</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875177.1">
        <property type="nucleotide sequence ID" value="XM_007876986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P456"/>
    <dbReference type="STRING" id="1069680.M7P456"/>
    <dbReference type="GeneID" id="19896806"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03119"/>
    <dbReference type="eggNOG" id="KOG0974">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1147591_0_0_1"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051973">
        <property type="entry name" value="tRNA_Anticodon_Mtase-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="160"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="242" mass="27807" checksum="45913BAEDCA20003" modified="2013-05-29" version="1">MDFSVIEFSNKDNYLIVMACSDSSIRIWSFLYKTSEYILILNKKYSTKCLLNVTYILEKDYCYLLVTSTDGFITLWDISNYIYSSEIIIKSSEESFLPIWKNQIHQSNIKSMILRRLEENVYLLVTGGDDNKINILKIIVKLDSNLSNYKISSKTITNKLNAHNSSITGLAFSVSGLLFSIATDQKLKIWKIDTSQLVYLAEFYTYIADPCGISIAKVLNKEILAIYGVGLEFFSFDYTFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7P497</accession>
    <name>M7P497_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02852</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874890.1">
        <property type="nucleotide sequence ID" value="XM_007876699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P497"/>
    <dbReference type="STRING" id="1069680.M7P497"/>
    <dbReference type="GeneID" id="19896539"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02852"/>
    <dbReference type="eggNOG" id="KOG0467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_3_1_1"/>
    <dbReference type="OMA" id="FARCDIQ"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16268">
        <property type="entry name" value="EF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000002">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000746">
        <property type="entry name" value="Ribosome assembly protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056752">
        <property type="entry name" value="EFL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25118">
        <property type="entry name" value="EFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="3">
        <location>
            <begin position="17"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1009" mass="115457" checksum="685E7A31FB9744D2" modified="2013-05-29" version="1">MPSVLPEILVNIQKNPDHIRNICLLAHTTLADRLIASNLIISNKIAGTIRYLDNRDDEITRGITMKSSAISLYAKIIKKDESNSEYMINLVDSPGHIDFNFEISAASRLCDGALIIIDVIEGCCSQTISMLRHAWTEKLKPILIFNKIDRFILELHLSPEEAYSNLLQLLNHVNAIMSTFFTEDNLKNLERNELLENQETNNTNNIVPPSYDKTDKDLYFSPEKGNVIISSAIDGWAFRINQFSEIYEKKLGIKQSILNKVLWGSFYLDPKTKNILQPEDLKGRNLKPMFVKLILENIWTIYHSIILNKDQNKIEKIISNLELKIPHREIISKDSKCLLTSIFSQWLPLSTSVILSIIDQIPSPKKSQKLRLSHIIEHSPNFDLVPSYIYNSIMECSTNNLSPVIGYVSKLIPIPIKELPKDKKIYTKLENENQEIQIKISEKDSPLCETYVLESSPDYILEKNNYNSLEHTKHFEKNYFIGFTRLYSGIINIGQELYVFKPKYDPKTPEKNISKIIVSNLYLLMGKELIQIEKVYAGNIFGIGGLEESIIKNGTISSLPISYNLASIINDAPIVRVALEPTSPSDMQKLTEGLKLLNQSDPCVQIQHQDSGEHIILATGELHLEKCLKDLCEKFSKINIHVSKPIVPFRETIVKLKENNVPKGIVEVSVPLTNIKIKLRVYPLPKDITEYIYSFSKVIKDAYLYIEIADSSITNRLDTNFTNNFKLDNFKKQLFEKLNSTEKTDIDWTKVYERIVAFGPNKTGPNILIDNTGKLRKLFINNTFIAKNLNINNDLQSLSFNEIEKHINTGFQLSVLQGPLAEEPMHGVSIFIEDIEFENININHKLKIEQITSHLISSFKDGIKQGFLDWSPRLMLSMYACDIQAPGNVLGKIHAIISKRRGRIVSEELKGTLYLIKALLPIVESFGFSKDIRKKTSGAANPQLIFNGFEILDQDPFWISRTEDLEDTENIKNKENISQKYINDIRKRKGLFINQKIIFRAEKQRTLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7P4U5</accession>
    <name>M7P4U5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome assembly protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Notchless protein homolog 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ribosome biogenesis factor RSA4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_02637</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NLE1/RSA4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874656.1">
        <property type="nucleotide sequence ID" value="XM_007876465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P4U5"/>
    <dbReference type="STRING" id="1069680.M7P4U5"/>
    <dbReference type="GeneID" id="19896328"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02637"/>
    <dbReference type="eggNOG" id="KOG0271">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_16_1"/>
    <dbReference type="OMA" id="AWEPYHR"/>
    <dbReference type="OrthoDB" id="10267436at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110136">
        <property type="term" value="P:protein-RNA complex remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000092">
        <property type="entry name" value="notchless protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="129"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="172"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="215"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="263"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="386"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="428"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="470"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00068030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00080836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="503" mass="56415" checksum="B28422E966ACD53D" modified="2013-05-29" version="1">MATLPPLNLRKQKSPIKNAISVEIPEHFQSVLCRFKGLDGISSIPSTLIPGNISLEDLGILLNKLLNNNERISYLFSAEIDGKWIEIKENLYSSIFHNNLKSTEDELTLIYIPQENFRVRAINRCTATISGHNKEILCAQFSPKTSSYFSTGSGDGNIRIWDCDTGTPLHTLKGHSNWVLCISWSPDAKLVASGSMDNTIRLWDPEKGKNVGEALKGHTKWITSLSWEPIHLSTENSYRLASSSKDTTVKIWDINSRCILLTLSGHKSSISCVKWGGNGWIYSASHDKTVKIWDGKTGKLLHTLLAHAHWVNTMALSTDFVLRTGAYDYTGIIPSSFEEMKSKAKKRYDEIIAYGGNKGERLVTGSDDFTMYYWNPEESVKPIKRLTGHQNLVNHVSFSPNGQWIASASFDNSIKIWNGLTGEFIVTLRGHVASVYQCSWSNDSRMLVSSSKDTTLKVWDIHEKKLKCDLFGHVDEVFACDWSPDGIRIGSGGKDRDTKIWSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7P4X0</accession>
    <name>M7P4X0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874691.1">
        <property type="nucleotide sequence ID" value="XM_007876500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P4X0"/>
    <dbReference type="STRING" id="1069680.M7P4X0"/>
    <dbReference type="GeneID" id="19896360"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02669"/>
    <dbReference type="eggNOG" id="KOG4539">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043838_2_0_1"/>
    <dbReference type="OMA" id="PFFYLAY"/>
    <dbReference type="OrthoDB" id="5562676at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018786">
        <property type="entry name" value="Mit_KHE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062">
        <property type="entry name" value="K+-H+ EXCHANGE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10173">
        <property type="entry name" value="Mit_KHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="248" mass="28927" checksum="74E09BDD34310B32" modified="2013-05-29" version="1">MKLFIIPITRNRFFLYCHQNSIHSKPSLIDKFTNKVGDLWKNWGQSEIKWKKRLVELGNKIVDSLPYEEWSLRNIPSRKKVDQIQGTGSSQYKVTVHYPTSIGPEKAIFTISDLVERRALFHKRWMIFSIIGTPFTLPLALIPIIPNIPGFYLLYRAYSHWKAFHGAQHLKYLLKNNLFYPSASSSLEKVYGNSLQNTTHDDFLLNTTKISIISRIIDNKDFKMHLERAIRQLQKENSLQTSNLSMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>M7P5R2</accession>
    <name>M7P5R2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor Tu</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02541</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874554.1">
        <property type="nucleotide sequence ID" value="XM_007876363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P5R2"/>
    <dbReference type="STRING" id="1069680.M7P5R2"/>
    <dbReference type="GeneID" id="19896233"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02541"/>
    <dbReference type="eggNOG" id="KOG0460">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_0_0_1"/>
    <dbReference type="OMA" id="EGDKEWG"/>
    <dbReference type="OrthoDB" id="2067at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03707">
        <property type="entry name" value="EFTU_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000001">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000003">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000766">
        <property type="entry name" value="PRK00049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009372">
        <property type="entry name" value="PRK12735.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009373">
        <property type="entry name" value="PRK12736.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF36">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="53"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="444" mass="49623" checksum="527B37C9BE8E544A" modified="2013-05-29" version="1">MITKAIKICNLSKPLRPFFSSNTRWNIWSQIEHQKIIYRQTIVRNMATFDRSKPHINIGTIGHVDHGKTTLTAAITKCLSTINQTSFKDYSEIDKAPEEKARGITISTSHIEYETKKRHFSHVDCPGHADYIKNMITGAAQMDGAIIVVSATDGSMPQTKEHLLLAHQVGVKHIIVFINKVDAVHDKEMLELVEMEIRELLSTYGFDGEKTPIIVGSALCALEGKKKEIGEDSIWKLIDAIDNHIPVPQRDIQKPYLMPIEDIFSISGRGTVVTGRVERGTLKKGEEVELIGFGTPIKTIVTGIEAFNKELDQSIAGDNCGLLLRGIKREQVRRGMVVARTGTVKSYKKFLASFYILTEKEGGRKTGFVNYYRPQMFCRTSDVTIILSHPKETKDADSKVVMPGDNVELVCELIHDIALEDGMRFTIREGGKTVGTAIITKILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7P684</accession>
    <name>M7P684_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycosylphosphatidylinositol anchor biosynthesis protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02315</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874314.1">
        <property type="nucleotide sequence ID" value="XM_007876123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P684"/>
    <dbReference type="STRING" id="1069680.M7P684"/>
    <dbReference type="GeneID" id="19896008"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02315"/>
    <dbReference type="eggNOG" id="KOG3144">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1180636_0_0_1"/>
    <dbReference type="OrthoDB" id="17366at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009580">
        <property type="entry name" value="GPI_biosynthesis_protein_Pig-F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06699">
        <property type="entry name" value="PIG-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="27456" checksum="C639F0721E860237" modified="2013-05-29" version="1">MLLHHYSFKIYDIFHPFILLFFLYLNFNSLLIHTVKTLIGSLFIPVFLLQILRFVVIVNLKKAHVLYVCFIDKFVFLSYLKVCLCNQKICLIFKNMTIVCLYFVFSCILVHIFIVFYGALVINYLLETILCALHLTVLGILPMICIFGVDRRKYMELVSLELDLENFENLKLSVGFFGTFVGSWLGAIPIPLDWNKGWQKWPIPIVIGGYLGYSLSIFIIFLVYVKKSIFFKKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M7P688</accession>
    <name>M7P688_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874319.1">
        <property type="nucleotide sequence ID" value="XM_007876128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P688"/>
    <dbReference type="GeneID" id="19896012"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02319"/>
    <dbReference type="HOGENOM" id="CLU_1124935_0_0_1"/>
    <dbReference type="OrthoDB" id="10502500at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082955" evidence="2">
        <location>
            <begin position="20"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="247" mass="27158" checksum="3B8F60A4923126B8" modified="2013-05-29" version="1">MRFNFILSGVLALASLVSAALNVASQQVSEFSLKELVDLEVHRIPYSHLDLVLVCFYKGGLDDLYTIKQGLSFSASLNSKVRIAHISRKCDSFFLKVLAYDECDNLFVYFSSGFSVSVSGRVEYHRECVPAKVVQPSQTTKPVPQLTDASTSTSDTLCDETPTKTEVKVPTKTYEGQEQLIPSRSVPLPSTRKTEPIETLTSATHSQTSATDVKPTRKPDDIDNSGSVLTFKLFGTLFAVLVIFLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6J1</accession>
    <name>M7P6J1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02088</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874068.1">
        <property type="nucleotide sequence ID" value="XM_007875877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P6J1"/>
    <dbReference type="STRING" id="1069680.M7P6J1"/>
    <dbReference type="GeneID" id="19895782"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02088"/>
    <dbReference type="eggNOG" id="KOG3436">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110381_1_1_1"/>
    <dbReference type="OMA" id="VMNQKAR"/>
    <dbReference type="OrthoDB" id="528635at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000002">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3450:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_uL29_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045059">
        <property type="entry name" value="Ribosomal_uL29_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="123" mass="14374" checksum="49D370405384D84B" modified="2013-05-29" version="1">MAKASAYFLRKKSKAELEKELEELKQELLTLRVQKISGGAASKLAKISNVRRSIARIHTIINLTQRQQLRLFYKGKKYIPLDLRSKKTKASRLSLTRHEKSLKTLKQQKKCKYFPRRVYALEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6L9</accession>
    <name>M7P6L9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nop domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02115</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874097.1">
        <property type="nucleotide sequence ID" value="XM_007875906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P6L9"/>
    <dbReference type="STRING" id="1069680.M7P6L9"/>
    <dbReference type="GeneID" id="19895809"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02115"/>
    <dbReference type="eggNOG" id="KOG2574">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026337_2_0_1"/>
    <dbReference type="OMA" id="IGNGPMD"/>
    <dbReference type="OrthoDB" id="4771285at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000002">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein Prp31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000003">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027105">
        <property type="entry name" value="Prp31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019175">
        <property type="entry name" value="Prp31_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09785">
        <property type="entry name" value="Prp31_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="237"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="355"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="506" mass="56161" checksum="D9DFF8CDA6601E65" modified="2013-05-29" version="1">MDLADELLHEVFDQSDVDDVDEKIQKPLEGAFSFSNGEMTLKTHEDRNSSGITKNSRKTEKNGTEKTQLSSTKKLFNVHTLLKSEFMINILNKIDAYSKNQTLSFQGNIEDHPEYQLIVDSNNLAVEIDNEIITINKFIRDNYSQRFPELESLVVNPLDYAKTVRIIGNQMDITQVNLSHLPSATVMVITVTNSTSEGTLLQQNKLDMVFEACDLTLELESAKKKILEYVQSRMNLIAPNLLAIVGSTTAAKLISVAGGLAGLVRMPGCNISALGAKRQSQTGFSSTIGIRHQGFLFHSEILQKVPPDLRKQALRIISSKIALASRVDRLHQSPDGSIGASLREYIEKRLDKLSQPNPSKTVKALPAPNDAIKKRRGGRRMRAMKERYQMTELRKQQNRLAFGKQELEVSINDEMEGMGMIGQDGQYRIRAPIIDSRSKAKVGKAIKHFASFSHNSGTATSGLASSVVFGSNVGMQLINPELLSAPKTTESNDWFKGGTFTQVHKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7P7I5</accession>
    <name>M7P7I5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear pore protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01991</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the nucleoporin interacting component (NIC) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873971.1">
        <property type="nucleotide sequence ID" value="XM_007875780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P7I5"/>
    <dbReference type="STRING" id="1069680.M7P7I5"/>
    <dbReference type="GeneID" id="19895685"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01991"/>
    <dbReference type="eggNOG" id="KOG2168">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011846_0_0_1"/>
    <dbReference type="OMA" id="LLMCGQF"/>
    <dbReference type="OrthoDB" id="1918363at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044612">
        <property type="term" value="C:nuclear pore linkers"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044615">
        <property type="term" value="C:nuclear pore nuclear basket"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007231">
        <property type="entry name" value="Nucleoporin_int_Nup93/Nic96"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93 NUCLEOPORIN NUP93 DEAD EYE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04097">
        <property type="entry name" value="Nic96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="4" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="909" mass="104343" checksum="AD256003A8443602" modified="2013-05-29" version="1">MYHQEPSLKPPSLSDILESSKKLQHKLFRLELPQIQLGLDQIRQCSEEQVLNLGMRDGDTKAHYLLAGSGMNAKETLQTLMSIQLLPFYESAPLMDTDIDGYLRYKKERNILLAIEDMIKQSQRDFDAFVARNVNYKLEKNKMNLLNDFQNTKELSNVKQNDVSKEELKNVTESTMEKSFFESSFKKSRFAKSAFKDFDDVELSVQHTPVISTIRQKYAEIVSLLNEFRLKGKGFGIFNAFCDVLRLYRGDIRYQQLSDSWKLLSKIVEENNYLYDSVSSKTTNERQFVSYIDNPASRPAMFKKIVSGAKSFLEFQFFSLIEREIIKYPHDAKLGGVPSAENKIRAYLNIKFMKNGRWIKSNLEIVNNIPIWAFLFYLIRCGYLEEAVQYTLKHESLFQKIEKAFPIYLKAYFMSPNGKLPRQLNDRLHAEYNQRIRFITETSDPYKYVIYKIIGRCELSKRSLPEVLPLAEDYMWLQLNLIRSIEDSGESVHERFTLEDVQKTLLSFGAKHFTSKGTNPIVYFQLLLLSGQFERAIYYLYSYYPIDAVHFAIGLTYYGLLHIPVVDNSLETELLSINDNNIACLNFSRLICVYTKTFQKLDPRVAVDYLCLICLNGDLSPPIGNAQKNICYEAIKELVLSTRDFSQLLGDVKADGSREPGIIEKRLELIQLHSESEYLKTITEQAAIQADNDGCTADAILLYHLSEDFDTVVSIINKVLGEALSSPSLSTYVESGNSSLKINLSLMAMEDPRRLAENMMSVYFNNVEIYSKITPTNRDACKTLLKIADARAAYKEGKWEQSLMIIEQLNVIPLDCNADIGAIKKQAQDFSSLHGSIARNVPGLLVMSMECLYKLNNKLKLSPFSDSSRNAKLIELRKRAKSAMIYAGLIQYRMSSEIYSHISRLDVMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M7P7P6</accession>
    <accession>M7NP85</accession>
    <name>M7P7P6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major surface glycoprotein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02060</name>
        <name evidence="3" type="ORF">PNEG_02418</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Rovira Torres L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <title>Mechanisms of Adaptation to a Mammalian Host Environment by Pneumocystis, an Opportunistic Pathogen of Immunosuppressed Patients.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C.A."/>
                <person name="Ma L."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Bishop L."/>
                <person name="Fantoni G."/>
                <person name="Sherman B.T."/>
                <person name="Jiao X."/>
                <person name="Hu X."/>
                <person name="Yang J."/>
                <person name="Jones K."/>
                <person name="Raley C."/>
                <person name="Stephens R."/>
                <person name="Lempicki R.A."/>
                <person name="Kovacs J.A."/>
                <person name="Chen Z."/>
                <person name="Abouelleil A."/>
                <person name="Goldberg J."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Sykes S."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
                <person name="Gabriel S."/>
                <person name="Lander E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09072.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09880.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874041.2">
        <property type="nucleotide sequence ID" value="XM_007875850.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613298.1">
        <property type="nucleotide sequence ID" value="XM_019757743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P7P6"/>
    <dbReference type="STRING" id="1069680.M7P7P6"/>
    <dbReference type="GeneID" id="19895754"/>
    <dbReference type="GeneID" id="19896111"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02060"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02418"/>
    <dbReference type="HOGENOM" id="CLU_010455_0_0_1"/>
    <dbReference type="OrthoDB" id="5415993at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003330">
        <property type="entry name" value="MSG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02349">
        <property type="entry name" value="MSG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="783"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09072.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR09880.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1113" mass="128375" checksum="7CADE9E08AC5C9FC" modified="2016-03-16" version="2">MYSNLSNILKLNAYDMFFHTIYIIILIELLSLINSAYGRQNIPLRSKEAEMNSVNSSFEYLVDEESIYALILKTNYNNEAKCKEELEKYCEELKEVDLNLESVDNRVKEICNDRGKLEKKCQDLKTEFTKKLKKIEDKAKQLIDDPKDEDCEEYEAECLFLDQSSPLLSYYCNKMTNECYKKKRQKVADEILFRALKGTVNDTDKCKERIKEVCPILSKESDELMLLCLYPDSTCKKLEKKIDYFCNFLRTELNNNELEEKCHERLGDCYFYGENCNKTKCDEVKKQCEEKGITFKIPGSDFIPIKPKVTLLEEIGLEEVFKRAKDKGIIVGRSGEKKLEDMLLLLSKDEKNKNKKCAKALSVCSTSDYLASELKTLCEDSEKESKCENLMNVTIRCSNFRSKLYTNKLSPYSNNKDAETILRHLLPRSLTEEECIMFESECFYLENICSEILKKTCKNLRAACYRKGQEAILYELSKDQLRGKFNLKSENKSVKECQKEVLKNCRKLKENKEQISRCIKPKQVCLEFSEDISTRSKGLKRNLDMIRDSFTKKECVELKKSCEDLEKDSSLNYWNCITLNIRCKYSEVVEELKNRFLKEKKDTLKNQENCERALKEKCDGMFKKETNLFRISCVLQKETCQSIRKGMESHCHLLKENIENQNILDEKSGKGNETLLERICLLWSPYCDQLMENCPDLLKKESNGNDGVCLKLKEKCKPFREKEHLDDELTYKLKGNLGDNAKCKVALENYCVQWKTGTNDTLKSLCNTNKNMNVENEICKRLLEKIAEKCSTLKTNLEKAEKELQEKEKEYEKVKKETKEAMEKSGIFLSRPKESLDQQSIQANAVNSSVLLSSILPENYLNKLSNAKTKLRVIQKSYVDTETSEVEKEGFNAVVRILELYLEFKEECKVLQLDCDFKKDCPESEEVCKKIEKLCELKPLEIKPSNATIMTTTIEGSLCNVTMATEPGKTTEKTITIIKTMNETATKQRSTITLTRTKIIGEGNFTSLCDINIQETNVSFYTSTLTSTLTSTLTSTLTSTLTSTLISTSIITSTVRLTSIQKCKPTKSMIDSTKETQKEEEKEEKVKLNEGMKMRVPEIVKIILLGVMVIGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7P896</accession>
    <name>M7P896_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosomal protein L27a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01379</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873314.1">
        <property type="nucleotide sequence ID" value="XM_007875123.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P896"/>
    <dbReference type="STRING" id="1069680.M7P896"/>
    <dbReference type="GeneID" id="19895076"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01379"/>
    <dbReference type="eggNOG" id="KOG1742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109163_1_0_1"/>
    <dbReference type="OMA" id="WGRVGQH"/>
    <dbReference type="OrthoDB" id="61900at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="6">
        <location>
            <begin position="72"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="148" mass="16881" checksum="A9E5A1B855F23EB5" modified="2013-05-29" version="1">MPTRLHNTRKHRGHVSAGYGRVGKHRKHPGGRGLAGGMHHHRINMDKYHPGYFGKVGMRYFHKTNNQFWRPPVNVEKLWSLISKEEREKFLNQKTDTSPIIDTLVHGYGKVLGKGRLPSIPIIVRARHVSQTAERKIKEVGGIVELVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>M7P8W8</accession>
    <name>M7P8W8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PNEG_01530</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873475.1">
        <property type="nucleotide sequence ID" value="XM_007875284.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P8W8"/>
    <dbReference type="STRING" id="1069680.M7P8W8"/>
    <dbReference type="GeneID" id="19895225"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01530"/>
    <dbReference type="eggNOG" id="KOG1123">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008213_0_0_1"/>
    <dbReference type="OMA" id="MIANTRN"/>
    <dbReference type="OrthoDB" id="10262986at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000019">
        <property type="term" value="P:regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001111">
        <property type="term" value="P:RNA polymerase II promoter clearance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001113">
        <property type="term" value="P:transcription open complex formation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001174">
        <property type="term" value="P:transcriptional start site selection at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18029">
        <property type="entry name" value="DEXHc_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18789">
        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000077">
        <property type="entry name" value="Probable DNA repair helicase RAD25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000117">
        <property type="entry name" value="Putative DNA repair helicase rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00851">
        <property type="entry name" value="XRODRMPGMNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="374"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="590"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMR10265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="850" mass="98015" checksum="7FB62BD1BBE1C0F9" modified="2013-05-29" version="1">MLTNDIQETSDEVINSNKNKRRARSPTPDYVCQEFSDEEYFKRNKDIQGQDVKSTRIKIKLNHGNNTFNTETQQKYSYDSVAYIFGENDFSSVLKLKSDHESRPLWINPYDGKIILEAFSPLAEQAQDFLITIAEPVSRPIHIHEYRLTAYSLYAAVSVGLETDDIISVLDRLSKFSIPENIIEFIRMYTISYGKIKLVLKQNRYFIESSHVEILQKLLKDDVIGPLRLEAEMSRNKSYSSTLNSQTNDIYSDKKKNIEDKCKNSKDNDSGDNIKDEESTSKQIDQNEAKNLEEIGELFPAIDIDHDDDDDDNVHSFEIPSSSVEIVKKRCSEIDYPMLEEYDFRNDTSNPDLEIDLKPSTQIRSYQEKGLSKMFGNGRARSGIIVLPCGTGKTLVGITAACTIKKSVLVLCTSSVSVMQWRQQFLQWSNIKNEDIAVFTSDNKEKFKGESGVIISTYSMIANTRNRSHDSQKIIDFLTSREWGFLLLDEVHVVPAIMFRRVITTVAAHAKLGLTATLVREDDKIDDLNFLIGPKLYEANWLDLAQKGYIANVQCAEVWCPMTTEFYNEYLNETSRKRMLLYIMNPNKFQACQFLIDYHEKRGDKIIVFSDNVYALRAYALKLQKYFIYGGTSQHERIKILENFRYNDMVRTIFLSKIGDTSIDLPEATCLIQISSHYGSRRQEAQRLGRILRAKRRNDQGFNAFFYSLISKDTMEVYYSVKRQAFLIDQGYSFKVITHLKGMENLPNLAFSTPAEQRELLQEVLLQNEDAADIDKSDERDGHYDNFSKKSKKDLYNFSKIKRNITNLSSLSGGDDFAYIEYNKSANKQLKDFAVARNPIIKKFYAQRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7P9H6</accession>
    <name>M7P9H6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873149.1">
        <property type="nucleotide sequence ID" value="XM_007874958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P9H6"/>
    <dbReference type="STRING" id="1069680.M7P9H6"/>
    <dbReference type="GeneID" id="19894927"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01230"/>
    <dbReference type="eggNOG" id="KOG2190">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022670_4_2_1"/>
    <dbReference type="OMA" id="SIAKEPH"/>
    <dbReference type="OrthoDB" id="442947at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070935">
        <property type="term" value="P:3'-UTR-mediated mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903138">
        <property type="term" value="P:negative regulation of cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903753">
        <property type="term" value="P:negative regulation of p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22455">
        <property type="entry name" value="KH-I_Rnc1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22456">
        <property type="entry name" value="KH-I_Rnc1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22457">
        <property type="entry name" value="KH-I_Rnc1_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049786">
        <property type="entry name" value="Rnc1_KH-I_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="70"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="158"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="303"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="386" mass="41891" checksum="9870CC598985B9ED" modified="2013-05-29" version="1">MTELSTSFNVDKMARFPGLPLGTTHGTANNVSNDGLTKNLLFESSYTPLQGNGEVQESRIETKNEGYSNSQLTLRALVSTKEAGIIIGRQGKNVAELRGANGIKAGVSKVVPNIYDRVLTISGTLEGVSKAYGTIAQSFINNPIGHSNHHLTSSSSEPQSSIRLLVSHNMMGTIIGRQGLKIKHIQDISGARMIAFKDILPQSTERIVEVQGVVSSIQSAIWEIGKCLIDDWERGIGTVFYNPSVRLSSASSIVPGHQTNSIFSGPQSGHFLQYQRQGSHLSYSRLSNLASHFQESLDASSQDICVQNISIPSDMVGCIIGRGGSKISEIRRISGSKISIAKAPHDETGERMFTIQGTSSSNEKALYLLFQTLETEKNRRGQENLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7P9S9</accession>
    <name>M7P9S9_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873260.1">
        <property type="nucleotide sequence ID" value="XM_007875069.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7P9S9"/>
    <dbReference type="GeneID" id="19895029"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01332"/>
    <dbReference type="eggNOG" id="ENOG502QSDS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_236057_0_0_1"/>
    <dbReference type="OMA" id="GDILQYC"/>
    <dbReference type="OrthoDB" id="2386201at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035361">
        <property type="term" value="C:Cul8-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019021">
        <property type="entry name" value="Mms22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28122">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SUBSTRATE RECEPTOR MMS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28122:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SUBSTRATE RECEPTOR MMS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09462">
        <property type="entry name" value="Mus7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1985" mass="234604" checksum="6D1E9F56F068E397" modified="2013-05-29" version="1">MILVKDIVFPEKKAFSNLEISCSEGEDEAWSTEIEEDISKDEGLVRIEEEKIAEKLLEKRQFRKRRPEQKRPYTYDFLKHNEEFRRIGIKPMESEFMEHLNLDDEDTQYESQDSKDSQTTLAHIISENEDFELEEFKRNKPSATFINPNRHNWRLNRVKKALQKQTSSASKSTKKVKDFLHYNSDTEITMLKSIQNFKRVSGIENEECGSENNISDVSETFSNHHSPSFVRTKHNSRIKYILQDSSESDIKKDDSCYEEHNFINDISHYKRKLKGILPPSYLTLENKFIISNSYSKINTPAKKTNIQEENKKGLVKRKMAKFPSTLKPFLMDLDTNNLTHQPKKAKYLDFKENNNNNYYSSNESSNGNDVSERKLINRMYAGTKSNNHMYFPKEHRRDNTRENSLKKTSKYLLPEKIKRLNKFPSKFIKKKKVTKIGILDLFKKHKDKNQQALPRFINLVCRIMKSRKDLGRTYPYRKVFFFDNFDDRQEINKIFEKWKQGTLTPIYSKNDIFSCYTKPKSITNSINFTENIPCLSAEIHEIKQNVEVKDNNSRKIIGKILFQGELKKKISENFMKRPNESYCRKNNPKSCITNKYESIYEWLNKLSSSKPDIIDKIDNNMENKINDPKIRHYNRKSIAKRIDSNHFDDTIIHRHIINKVNARRENSNNYFQQSLEQFWLQKSTFSMTFNVNPIKQDIFFDSETFIGSGLLQKLLSESDNDANQPLYSIDCYTIFDYKMQNNLFDDIEKIQKIFEELSYNILKYNIQQSKEENIVDNSLYSHLLYIFRYINFRLQNNTSELLIEFSKNLLELCENLSQQLIPSIQICENLSLKSIPVKLFFQLQMFFLVFAFKFAKSYFRKNEVPKFHDMCRIITDISQRLVKHLLQFGFDSLNSGLRKQNSSKYSSKGINNNDYFIEVWVVTIHIMDFSNNLFGEFVPNFWTLLNSELKIINSSEIYEFLDHEKCWYSIINLTVLYQFNISGVSGIPNGLANWIMIERILSNFFENTEIYKKELGNSQNMYIRTLFGRCHYLISTWKWSNAKSIVILLYTFFCKRQLRNLINENTPGYPSFIQNLKDLPSTSIETSDTCFHIFLKVIILVLDQLKIQLNSSFIPSKDLKILISRITPLHNRKYSNNQELSIQDFISLENHHSLLLILFRIVPNQYRPPITMIQDLVQIENAHCKAKLVNLKAWLYLTRFLLFNSNNDDFQAVCNWYNMVLDTTREEYMSIYRTHKRQSESKTLKYLPNDKLLEYNLKQLENAMISCLRCKKEIINSVESNVSKGKILQLFCKASSTNIFNSSSVIPSSVIIEALNLTSSFIRRLCKKSSYEKYTESYMEDSQDYGDISIFYDLVDNNDSENNIEHDFSVIINETLSGQIFQMLSNYLGSDVEISYELLNAIIECWVLTADLLVRNGIKEWSNYLDYGQESWIRFGNNSKINQAGVIFMSKVIQECPNAYFSYRITFISYWFRVIVEDKLYNQHTLTSLILNIDSSNKLWRNVQFSKKSNLFEIKLHEIKHHQFSIISNTLANMGEIYTHLESENLIQNTKSEFLTYLSNLFHSMRDTYQKLVQENDNDIKKYIDLCQKLIGCVLQYCGEFVNENTLPILDWFINSTNFPQPKEDIIYTAKKLKGYEKRNLNDPLIQQELFRFIKAKCEIALFEHKRNQFSTLMRLVLSDTKDYNIIIHRKIQTLDLVCFIIDEVFSAYMAYSKSHITWIYIIPMLEATKELFSSLLEYKYQNFYICSILNIMESFFQVLLSCLKTFFESSTLLAIYGSVKIFEILAILVELLGSINYTDYYKNKHLYIAENKNIENLWKYISKFLKLTPIFVSWISWGKENIHWPDLYIVELQKKHLETIQRQIYREWTLKESQKNYTWLHNFRNQEIKLISDFNQEEIKQLLLKGVFDFIACLFSCGGVWQLHIKELIPSILFKGLSVDHNVIVKFMANIGELNEYDYLWKNIFSIPNNTQIIYTECLGNLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAG4</accession>
    <name>M7PAG4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Endocytosis protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PNEG_00976</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the END3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872890.1">
        <property type="nucleotide sequence ID" value="XM_007874699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PAG4"/>
    <dbReference type="STRING" id="1069680.M7PAG4"/>
    <dbReference type="GeneID" id="19894674"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00976"/>
    <dbReference type="eggNOG" id="KOG0998">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040829_0_0_1"/>
    <dbReference type="OMA" id="DEHISHN"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990964">
        <property type="term" value="C:actin cytoskeleton-regulatory complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030476">
        <property type="term" value="P:ascospore wall assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025604">
        <property type="entry name" value="End3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF74">
        <property type="entry name" value="ACTIN CYTOSKELETON-REGULATORY COMPLEX PROTEIN END3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12761">
        <property type="entry name" value="End3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EH" evidence="18">
        <location>
            <begin position="8"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="19">
        <location>
            <begin position="40"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="18">
        <location>
            <begin position="137"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMR10830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="377" mass="43936" checksum="397B8B5E183A5D56" modified="2013-05-29" version="1">MEEITTEEQKKYWDIFISLNPINGYLSGDQAAKVLRNSKLSNEKLEKIWNLADIDKDGNLDFEEFCISMRLIFDVINKVYLEVPSRLPDFLIPTSKAHLIVAQEAIYENEQNAHLMQKTNKTKILSDNFDWYIQPSDKQNYEAIYSSNADLYGNISFNTLRNFYAILDISEEELRNAWKLVNPKMKETIEKDQAFYFLHILNQRNKGIRVPSVVPANLRATFEKNPVDYNINEVSSYKNDHKNAIFPQSSKHTSPVKKYDSSKEMHATYVEDSNMDGIRQKRQEIHYQGKKYRSDGSDEHISHNIILAELEQMLEFKKNELKLLKEGNIKSVTGMNDLESVQSDVLVMKQQIDNLGSYLIKKTDELQKLRSDIRQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAI8</accession>
    <name>M7PAI8_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PNEG_01006</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872920.1">
        <property type="nucleotide sequence ID" value="XM_007874729.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7PAI8"/>
    <dbReference type="GeneID" id="19894704"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01006"/>
    <dbReference type="eggNOG" id="KOG0386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_15_3_1"/>
    <dbReference type="OMA" id="VNYISHT"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17996">
        <property type="entry name" value="DEXHc_SMARCA2_SMARCA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000008">
        <property type="entry name" value="Chromatin structure-remodeling complex subunit snf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000843">
        <property type="entry name" value="Chromatin structure-remodeling complex subunit snf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014978">
        <property type="entry name" value="Gln-Leu-Gln_QLQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029295">
        <property type="entry name" value="SnAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08880">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14619">
        <property type="entry name" value="SnAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00573">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00951">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01314">
        <property type="entry name" value="SnAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51666">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="QLQ" evidence="17">
        <location>
            <begin position="101"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="HSA" evidence="16">
        <location>
            <begin position="341"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="512"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="820"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="13">
        <location>
            <begin position="1213"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1116"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1313"/>
            <end position="1342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMR10860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1342" mass="154835" checksum="F53293853F107812" modified="2013-05-29" version="1">MGDGASAPLGLTRESIQSMYWRWQMLRNQGATEATDLEFSQLSIVLKAIQQAQHIRHQNVKLVQSAGKSEERKTPEIGIDKKEEVLETEKQEVSGGLSQTTFTPEQLVTLRNQILAFKLISRNLPVPANIQQALFVNKPTDFSVSQISQGSSMGSSTLGEGEKLNQMEDVKEKIQDSESIDTVARESMAMKGCKTLGLSTSTLFNQEGLYRRVLIPSLMPSGIDPRKISQERKQAIAHRMAKRISELENFPGTLEDIYVTNTGKRNRNFENLNPSSRLKLKALIELKSLRLLEKQRMLRDEIIYSMAHFNTLTASADRAAFRRMKKRSLKECRLTEALERQHRTNKEQIQKQKQVSYLQGICSHGYDVIQRQKSLQAKIFKLGRSVLAYHSYIEKEESRRLERTAKQRLQALKADDEEAYLKLLDQAKDTRITHLLKQTNAYLESLAQAVKVQQNEFGHDDHDLSNQNEDEDKKIDYYNVAHKVKEAIIEQPSLLLGGNLKEYQLKGLQWMVSLYNNRLNGILADEMGLGKTIQTISLIAFLIERKRQNGPFLVIVPLSTLTNWTLEFEKWAPSVSKIVYKGPPLIRKHIQHQIRQGNFQVLLTTYEYVIKDRPVLGKIKWVYMIVDEGHRMKNTQSKLSYTLTTYYSSKYRLILTGTPLQNNLPELWALLNFVLPKIFNSVKSFDEWFNTPFANTGGQDKIELSEEESILVIRRLHKVLRPFLLRRLKKDVESELPDKVERVIKCQFSALQSKLYSQMRRSGMLYVNSGEKGRKGLQNIVMQLRKICNHPYVFEEVENIVNPERVSDDNLWRVSGKFEFLDRVLPKFFRTGHRVLIFFQMTTIMNIMEDYLNFKGYKYLRLDGSTKADDRSAAMKEFNHEDSDIFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQTKEVRILRLITEKSVEENILARAQYKLDIDGKVIQAGKFDNKSTAEEREAFLRSLLETENDDNADGGEENETFDDDELNEIIARDDEELSIFREMDEKLRLESPYGPGKKLERLMTEDELPEVYTRDECLEPDEVLSVTGRGARERVQIHYDDDLTEEQWLEAIDNDELTLEEVKQKKREKAARRLENKLKKQKLMSNSSNSSASGGDVIKRKRGRLRINSSNSNNDERRKRQKVFSSSQDKPQKSKNKNSVDLSNSEKSLILKDIFQKCYDAVISSVDSETNHSRSEMFLELPNKRIYPDYYMLIKNPIALNKIKKRLDSSYYTSLDDFKADFYQMFENARTYNEEGSMIYDDANALENVLNRSIEEFASEFIDKPLKKTSVSSKNTSNHVDNTTTHDTTTDLLNSDVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAX7</accession>
    <name>M7PAX7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWR1-complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_00628</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872527.1">
        <property type="nucleotide sequence ID" value="XM_007874336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PAX7"/>
    <dbReference type="STRING" id="1069680.M7PAX7"/>
    <dbReference type="GeneID" id="19894326"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00628"/>
    <dbReference type="eggNOG" id="KOG4776">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1058136_0_0_1"/>
    <dbReference type="OrthoDB" id="445677at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011421">
        <property type="entry name" value="BCNT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407:SF1">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07572">
        <property type="entry name" value="BCNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51279">
        <property type="entry name" value="BCNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCNT-C" evidence="4">
        <location>
            <begin position="188"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR11030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="263" mass="30458" checksum="B99E49A8809330E7" modified="2013-05-29" version="1">MFAILYIYIFKTKVDFDKMSHASIEESNKNSDNDDEFTDDDFILEEGDSEYDSKSSNSESDSCYDSGDKKVIDSLKRKKGNNDDFSCKNYNGVKTRSQRNRNEKVFISTPKSSQIDVNVIWNSMNDKKPSNEADYRPYNSSEEKVKISRIYEFAGKVETEEKFVPKDSLEAKVHFSSLNDSKITQFPLRKPTKRLSSLEISNNKPVKLNTLEKSRLDWAKFVDKEGISEELKNASKDGYMDKQLFLQVAEERMIKNIKESMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7PBE8</accession>
    <name>M7PBE8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA replication complex GINS protein SLD5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GINS4/SLD5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872706.1">
        <property type="nucleotide sequence ID" value="XM_007874515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PBE8"/>
    <dbReference type="STRING" id="1069680.M7PBE8"/>
    <dbReference type="GeneID" id="19894498"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00800"/>
    <dbReference type="eggNOG" id="KOG3176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071893_2_1_1"/>
    <dbReference type="OMA" id="ILETAWI"/>
    <dbReference type="OrthoDB" id="338231at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11711">
        <property type="entry name" value="GINS_A_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21692">
        <property type="entry name" value="GINS_B_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008591">
        <property type="entry name" value="GINS_Sld5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031633">
        <property type="entry name" value="SLD5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038749">
        <property type="entry name" value="Sld5_GINS_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206">
        <property type="entry name" value="SLD5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16922">
        <property type="entry name" value="SLD5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007764">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="7">
        <location>
            <begin position="67"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein SLD5 C-terminal" evidence="8">
        <location>
            <begin position="159"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="212" mass="25054" checksum="B94EA57D528FC212" modified="2013-05-29" version="1">MDLNLDTFFDLQDPSSDQNDRKNDLLQLMKSWISERTAPEILPCQTTLLERMMERIQRQISQDIKTNFRMILIQTEIERIKYIIRSYLQTRIYKLDKYAIYILQTPESLACLSSIEIEYLKKHQEILMNYYTSAVLKYLPKKLQRLDDTQGGISMIEKPDLETAVFCRVINTVEQDIPISKNETITLNKGNIYLLKYKVIRSFLRTGDVELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7PC28</accession>
    <name>M7PC28_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="4">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Palmitoyl-protein hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PNEG_00464</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872346.1">
        <property type="nucleotide sequence ID" value="XM_007874155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PC28"/>
    <dbReference type="STRING" id="1069680.M7PC28"/>
    <dbReference type="GeneID" id="19894162"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00464"/>
    <dbReference type="eggNOG" id="KOG2112">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049413_3_8_1"/>
    <dbReference type="OMA" id="WYDILAM"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000276">
        <property type="entry name" value="Acyl-protein thioesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="15">
        <location>
            <begin position="5"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMR11445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="223" mass="24969" checksum="28600D2089F13A05" modified="2013-05-29" version="1">MSFPAFIIPSRAKHTATVIFAHGLGDSGEGWKFLGEKLGSSGLFSHVKWVFPNAPIRPVMLNFGMKMPSWYDVTSLDEIDEEDEENMLKSCKEIQRLVMEEVKLGIKSERIVVGGFSQGCVIGLLSGLTCEKKLGGIVGFSGYLPLRKKIHLMLTECNLNIPIFMGHGKNDPIVKFEYGQESARILAEQLKLNVNWKAYDGLQHSVNEHELKDFSVWLGNILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCH8</accession>
    <name>M7PCH8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00051</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ERGIC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871905.1">
        <property type="nucleotide sequence ID" value="XM_007873714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCH8"/>
    <dbReference type="STRING" id="1069680.M7PCH8"/>
    <dbReference type="GeneID" id="19893749"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00051"/>
    <dbReference type="eggNOG" id="KOG2667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034705_2_0_1"/>
    <dbReference type="OMA" id="MTNHYLR"/>
    <dbReference type="OrthoDB" id="5541786at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF81">
        <property type="entry name" value="ER-DERIVED VESICLES PROTEIN ERV41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="7">
        <location>
            <begin position="19"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="6">
        <location>
            <begin position="159"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR11610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="333" mass="38221" checksum="3188A0A92123FE4C" modified="2013-05-29" version="1">MENFEGLPGIRKFSAFPHIKKLDYFPKIDSCYTKKSSKGSLFTLIWIILLIFFVWKEILIYKTGVEEHQFNIEKDLMEHITLNVDIVVAMPCDVIDVNVKDVTSELILAGQTLKKEGALFEPSSIDFSGKYFQPIESVKHVFQNLGKKSFKPGKNVLNASACRVYGSIEIHRVVGIFHITAQGHGYGIKHLSHKKMNFTHIINSFSFGTYYSNIISPLDKTGEITHENFYLFQYYISIVPTTFVKGNKRVLTNKYSVKGKASAVDYFNVPGILFIYDIEPISLTITGKRTSLFHFLMRIFAIIGGLTFFTEWLYKFVNQISEIIGFKKRYLHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCJ6</accession>
    <name>M7PCJ6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871925.1">
        <property type="nucleotide sequence ID" value="XM_007873734.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7PCJ6"/>
    <dbReference type="GeneID" id="19893767"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00069"/>
    <dbReference type="eggNOG" id="ENOG502QTEB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_252374_0_0_1"/>
    <dbReference type="OMA" id="LMHDSNK"/>
    <dbReference type="OrthoDB" id="160374at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052609">
        <property type="entry name" value="Ribosome_Biogenesis_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018849">
        <property type="entry name" value="Urb2/Npa2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682:SF2">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10441">
        <property type="entry name" value="Urb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal" evidence="1">
        <location>
            <begin position="1204"/>
            <end position="1431"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1432" mass="168568" checksum="2A2E2A825795AA87" modified="2013-05-29" version="1">MTNDIPVRSTQEVTRFLRNKSETLENKLKTANDLLNGNINIYFPQKENFLLNWVLDKLKEIIPNEKNSLKVISELWEFLRNVLESKDLLAESKYFNFQKHSFTTLLSITMSFAAKVKEKKLLSLISSITKTIDYILSEGTLFFFIKGSFDTTTTILADFFCCIKDLNLYNDTISILGSQIFGIWEKSIYGLENFKKVSKTISSKVLPHACYLIGKKDTPSWLNDLFSTVLYKTLFSPELLIDYINDQIQNSKSRNIALKESSLELFFNSLLNNLPKTSHFNILSSLPKFLEIAQNSVSYNSVYSKVKINVNPSKMMQLNDIFLSEILKFVFKLSLEQKTFKYSIILNILEVSKDNSISHKVSNIILEQQISEIFKDSFLLIKEDNTMMIGWKLLYTLLKFNFELILPYNEQLWTNLTQIDMTSEYSEICYELIKLFVNNYKMQRNLHEFINNWMKFLNFSLINNCILLSDEILIIVMGSANTLPLNKIKAIINYILEENNFEVLKKSVDSNELSLKNSLDISKNQIKSPFFVFYPLLSILHGLTDTEIISDIWKDMVKLYKSIIIEVFSNISTFLEDHGIHLIFRIHYKTMLLSHEYISSTDPYKNLEYIRSISNFKRISPKIFFYMIQCQLFYLQYFDQGYSENFKTENRLLLMDSILDDIIFFLRSTSINSLWKAGKMQLINKDNISIAYIYAINNNWLYLINKLCSFDKIKKFMNIFIKYSVESSLEVNISQLLSFSNLWYIFLSNAEIYELALLRDASLSAFTDYIFSYEFDQILFQDSIKSYSNKKHKNLIEDNKDDFDILKFRKIIKYLQIIPINCIKDSVKEKLLDFLFYIDFQFIKRYSMNIVLDESRKLLYRIMMTINTLNSLLYNIFSLVYFCVSLDNIKVKEESLISISSLISKEIIRKKIFSDNSLADKLIKIIKKYEINLLDYYHAFLYQQTENTFYIPGIIQLISIFFFEIQNNDKIHKKEFLKEEITKLMHFYFETIEKCLKKLLEICQKNTSNLEKALNSIYLFQLFFKLSFFFSEYDKDSLKQLIFLMSTCCFYYENINIYLYEKSQDLLLSLLKIHCNKIRSHDDILETSIVLITAFKNIQLSLTDIPKISTYYNFESLSIYCFIQQKSQSLKFQDFERICKVLCLSSWKVENINMAANILCAILLSRIEEVDESKKKYLELFQTFVSCLISVAKRAKDLEILYNFINLFNILLYKKSQYFSLQNLDQLFVLITITLSSSSPILNLSPNITIDDICKRFCKMISLILKKNYKKLNGRYHLLTNCFQSLLYLFAHDNTNTKITKNSFFHRIPNWILTSSCSISTAKIYSDSLLCWIQTSHSNKSSKKLKLNSFKTSEKAIAKYLLWIIVEYIKLLLNYSINSEIKVILTSSIMEIFKLLSTHELRMINNALDSQGKIVFKKLYSNYTQYDKWDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCK0</accession>
    <name>M7PCK0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_03360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875442.1">
        <property type="nucleotide sequence ID" value="XM_007877251.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCK0"/>
    <dbReference type="STRING" id="1069680.M7PCK0"/>
    <dbReference type="GeneID" id="19897047"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03360"/>
    <dbReference type="eggNOG" id="KOG3519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007879_0_0_1"/>
    <dbReference type="OMA" id="EVENIMP"/>
    <dbReference type="OrthoDB" id="1594986at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00014">
        <property type="entry name" value="CH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13246">
        <property type="entry name" value="PH_Scd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000046">
        <property type="entry name" value="Related to CDC24-GTP/GDP exchange factor for Cdc42p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010481">
        <property type="entry name" value="Cdc24/Scd1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033511">
        <property type="entry name" value="Cdc24/Scd1_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053026">
        <property type="entry name" value="CDC42_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06395">
        <property type="entry name" value="CDC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="79"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="220"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="418"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="5">
        <location>
            <begin position="854"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="805"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="811"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="823"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="949" mass="107671" checksum="5132E68766C32A1A" modified="2013-05-29" version="1">MTQSRPTKSNISANASNNFSKYNGLHSSGSVSSVETINNRNLSSKFVPLPANSITNKPAIASSSIYQICREIHGRLLNVPNFEIYLDNAKSQNDLSPAGIVNDPVSLLWQCFRQGASLCALFNALRPAKPLTVNPDSYLTSMNACKASVYHFLLACRNELGYKDDDLFSISQLYQDDTNGFVKVTKTVSLILDKLEEKNLLLKRKKIIYNDQDIKKPKDNRAKVVAELLDTERKYVQDMETLQNYMHALQSNEIVSADTIHLLFANLNMLVDFQRRFLIGIEANSALHPEHQRFGALFIQMEESFSIYEPFCSNYTYASDLAIEETSKLNKLAHIVEPTYELPSLLIKPIQRICKYPLLLKELLKYTDPSDPHYEELKQGMYAIKRVTDRVNETRRRQENEVVVMELERKIEDWKGHNVSNFGALLLEDVFIVIKGDVEREYHVYLFERILLCCKEIPASKKQAKVMSISKKSHKKRGNLQLKGRIFINSVLNIDSISKNGQYTLHVHWHNDHEKEFFILKCRNEENLKQWHNVLKKLIEESKSKDDTQINHNTMNYKSNKIDNQFNTMKSFNTKSKNYATDDSDNESSYKDVRDIIDNSNDIGTSTISKNLSSISVRSRSATNDSIASFGNNYYGTQIFSSRNPPQTSKVSQICYQSYSTNPKGVLENIDCKPFENNYMIPDSHISITTELSSNPTRESLGSSITDSYSFTGFNTQNTSNHDLDQLRYTIPSVSQTSHKNNNIPCSLHNYRIPAHPTSIPDIMSKNNTRSISNPVINAFPENQIPPNTSLLSSVSSSHIISNHKIEHNDSTSSISPNTSLSRPTTESPNTTTGNISPSTIPQTRLEGNKNENQVKIKVNYLDDIFVIIVAPTIGYAQLMERVERKIHLCGNYATKNLRQPLRIRYQDEDGDHITINSDEDVQMAVEMRHLYGTEGLSGAPGIVNLYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7PDQ7</accession>
    <name>M7PDQ7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CP-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_03080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08604.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613291.1">
        <property type="nucleotide sequence ID" value="XM_019757751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PDQ7"/>
    <dbReference type="STRING" id="1069680.M7PDQ7"/>
    <dbReference type="GeneID" id="19896767"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03080"/>
    <dbReference type="eggNOG" id="KOG1424">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_671064_0_0_1"/>
    <dbReference type="OMA" id="VNKADMM"/>
    <dbReference type="OrthoDB" id="61815at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01857">
        <property type="entry name" value="HSR1_MMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF2">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="6">
        <location>
            <begin position="107"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08604.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="553" mass="65445" checksum="C054EE8980E177D5" modified="2016-03-16" version="2">MRHRWILFYLKLISQKQKEKNIEIIEKSQRKNHILSQDKGKELLEIHQQLKSDLIIPRRPYWDSKTTAEELERNEKEAFLNWRRKLAFLQENYNLYLTPFERNLEVWRQLWRVIEKCDLIVQIVDARNPLLYKSKDLESYVEEMNKKNFLLINKADLLTEKQREYWADYFKMKGISYTFFSAVAKKSNDDQYINKKHKNSLKKVMNEIEEIFDEEILESEKDVFDSKLKIENNNPLKDERIRIVSVDELKDIFFKEIELLNNNNTENFEKFYVGLVGYPNVGKSSTINSMISEKKVSVSSTPGKTKHFQTIHITDKIVLCDCPGLVFPNFTTTKEELVCNGVLSIDQLKDYISPIALIVSRISKEVLEMIYGISLKIKTVEENGMEILAAEEFLEKYASSRGIDKSRASRHIIKDYINGKLLFCTPPPEIDPYMFNFEYYDSFKLSGDKCLQTKDYTKNGMISRPLKNNKKQTYSEDEQSLHTKLSRFDKDFFSQNRLSLNSNQKITKGFYYKKHIGPFTTHSFENYQNNILNKSKKHFNAHKRKKYYIQGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7PE02</accession>
    <name>M7PE02_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enhancer of polycomb-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_02872</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the enhancer of polycomb family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874909.1">
        <property type="nucleotide sequence ID" value="XM_007876718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PE02"/>
    <dbReference type="STRING" id="1069680.M7PE02"/>
    <dbReference type="GeneID" id="19896559"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02872"/>
    <dbReference type="eggNOG" id="KOG2261">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010580_1_0_1"/>
    <dbReference type="OMA" id="HIKWNEG"/>
    <dbReference type="OrthoDB" id="435275at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024943">
        <property type="entry name" value="Enhancer_polycomb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14898">
        <property type="entry name" value="ENHANCER OF POLYCOMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Enhancer of polycomb-like N-terminal" evidence="9">
        <location>
            <begin position="5"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="462" mass="54264" checksum="2940DF0EF80EDF9F" modified="2013-05-29" version="1">MSLNSKQVYIPTPDASKIVDNYEKLYKKTFIEPSTFIRFSMTVEDSEGCPYSMNEEDSDWLLKFNGSKRSRENYCSEDVFELIMNQFEVLTNEKQCLYTDVSQISDFSEFESAFVNSSISSYKYFAKQIYPYWKHRRISNNGKQLMPSLRFEENEKDDNDPYICFRRREIRQIRKTRRSDAQSSEKLRKLRSEMEQARNLIELVVRREQLKKESILLEQRIFNQRCHVKEIKRKLGIKDDDDDLVSHKKKKTHDNGSSTVHISVPQTTGFNEGDTFFLLEDYQAEKAAAAHSALEKALRQRQLSNVGWKDITDNPYCPYPKLYPLTFFRTITASYCLNTKKASLGLSSKEDYSSLPFDSSSVLSHSTKFNTRRLFYRQRIGRGGRIMIDRKSIVRYIHSPLLDPLVVDRYKYDHDDFDSEIEIDDMNELSLKYRIGLLSDEHNIFDQTSTCNNEVKSTNNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7PEF2</accession>
    <name>M7PEF2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex protein EXO70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02626</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Also plays a role in the assembly of the exocyst.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Bud</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EXO70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874645.1">
        <property type="nucleotide sequence ID" value="XM_007876454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PEF2"/>
    <dbReference type="STRING" id="1069680.M7PEF2"/>
    <dbReference type="GeneID" id="19896317"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02626"/>
    <dbReference type="eggNOG" id="KOG2344">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010236_4_1_1"/>
    <dbReference type="OMA" id="GIIRAGP"/>
    <dbReference type="OrthoDB" id="1922221at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.170">
        <property type="entry name" value="Exocyst complex component Exo70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004140">
        <property type="entry name" value="Exo70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046364">
        <property type="entry name" value="Exo70_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542:SF41">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542">
        <property type="entry name" value="EXOCYST COMPLEX PROTEIN EXO70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03081">
        <property type="entry name" value="Exo70_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20669">
        <property type="entry name" value="Exo70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex subunit Exo70 C-terminal" evidence="5">
        <location>
            <begin position="241"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="616" mass="71685" checksum="0104CE8883CFF00F" modified="2013-05-29" version="1">MLNSTSIWLDIDDDKADLGVLDETLRKTNELTDKISTIFSTLNYRLEKVEHTFKPIYKTTRSLIKTSENIQETIVAIDRTRKYFSIIPEAEEIIKRGPDGDLTFFLNTLKKVKNSLVILRVSNFRSSEKSILKLTQIWKGGCLQLYEIFQKILLDHSVPLEPLYYTTKNLEFPVIPKDSLSNIVLLSSFFYSTGFPESIKEIEKIYHEIRAEYLSESLKLLSKGSLSTALKRGNNMYERNSNGIIIYTQALLGMFKSESLIIRDVFPKNYQNVLLILIYPAIVTYCDTVQKLNQHIHQNMSTDFALSYEIIEEISKIMRFIDSYGNEGPVINELNKSMKMMENTGIYSLSDIIERIRKRISSISSMPTDGNVSEITIESISRLLYINDYEETVTYLIMSMKNEEWNSFLFTDNKKTFNSNTDKKIVYRNFFSEVVDILYSQIEQKARILLKKNSHLSLFLLNNLSYIEKNIKNTNLSSAISLNIFEKIAKIKNRYIDEYLETWKGCAENLLDVTYVRGGIANSIKLTLGSKERDAIKEKFKNFNNEFDELLKLNKMAVINDIELKSTLVGEVKRIVVPLYTRFYDKYFNSDFSKHQEKYIKYDKNTIDINLTYLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7PEG7</accession>
    <name>M7PEG7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Prenyltransferase alpha-alpha toroid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02641</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874660.1">
        <property type="nucleotide sequence ID" value="XM_007876469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PEG7"/>
    <dbReference type="STRING" id="1069680.M7PEG7"/>
    <dbReference type="GeneID" id="19896332"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02641"/>
    <dbReference type="eggNOG" id="KOG0367">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028946_2_2_1"/>
    <dbReference type="OMA" id="CHKTFLP"/>
    <dbReference type="OrthoDB" id="24893at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF4">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-1 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="8">
        <location>
            <begin position="3"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="352" mass="40090" checksum="B65481B2467B71E5" modified="2013-05-29" version="1">MSLDIDKHTKFHLRHLKMLPHDYLFSDTSRMSICFFCICSLDLLGSLETSTTSLQRKNWIDWIYSCQVSNGFRDWPTTESFQPSCHDLVHIVSTYFAICILLILKDDMKRLNKKNIIQLIVHLQNKDGSFRPCLGSDKNIQRLEKTDIRFTYCSIATLYILGCKNIDKFIHIESLLKYIESCKSYDHGFSENPKKESHAGYTYCAIASLSLLKNMSPFINKKLSSLCLEKTINWLLKKQLSNIDDYGGFSGRTNKSSDTCYSFWVGAALKCLQGDTDLISEESCKGFLLNRTHSIGGFIKSEGEHPDVMHSYFGLAALSIFGEKNVQEIEPALGISKSSLQGLKILNENLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7PGK1</accession>
    <name>M7PGK1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH-ubiquinone oxidoreductase 21kDa subunit N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02173</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874156.1">
        <property type="nucleotide sequence ID" value="XM_007875965.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PGK1"/>
    <dbReference type="STRING" id="1069680.M7PGK1"/>
    <dbReference type="GeneID" id="19895866"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02173"/>
    <dbReference type="eggNOG" id="ENOG502S1BF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087364_0_0_1"/>
    <dbReference type="OMA" id="TVPWFNF"/>
    <dbReference type="OrthoDB" id="196140at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053229">
        <property type="entry name" value="NADH-Q_oxidrdct_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024549">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_C_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019721">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 21KDA SUBUNIT N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10785">
        <property type="entry name" value="NADH-u_ox-rdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12853">
        <property type="entry name" value="NADH_u_ox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit N-terminal" evidence="2">
        <location>
            <begin position="9"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit C-terminal fungi" evidence="3">
        <location>
            <begin position="103"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR09589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="18631" checksum="EA5F972BE7ED615B" modified="2013-05-29" version="1">MVSAKKLHTEFPVIDTDPHFFRVIRYARPSDYIVFIMGVAGFPISMLVLEKLSPSLNKAGLAPALRLGGLLGICGGFLLAYQRSSLRLWGWTENAREVKMDKEEMEQKRAENKPLYGKSEMPEDIQRIAAQNSRYSALKFSAFPWFNFVNHNEHNTDSSKYQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7PHS2</accession>
    <name>M7PHS2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">5'-3' DNA helicase ZGRF1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873731.1">
        <property type="nucleotide sequence ID" value="XM_007875540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PHS2"/>
    <dbReference type="GeneID" id="19895459"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01765"/>
    <dbReference type="eggNOG" id="ENOG502SEDR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1338003_0_0_1"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052800">
        <property type="entry name" value="DNA_Repair_Helicase_ZGRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018838">
        <property type="entry name" value="ZGRF1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28535:SF1">
        <property type="entry name" value="PROTEIN ZGRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28535">
        <property type="entry name" value="ZINC FINGER GRF-TYPE CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10382">
        <property type="entry name" value="ZGRF1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5'-3' DNA helicase ZGRF1-like N-terminal" evidence="2">
        <location>
            <begin position="18"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="205" mass="24281" checksum="EBCC9CD0659EBFBA" modified="2013-05-29" version="1">MTTSTIQQHMEQTSIAKVDRFKCLWTANKHQIRKRWHDGILHFHTFNFRAMLYDEANVLIDDLFIPKQHIVSGNEIEFDNYLVIIEDALDAIYSDISSLYVRHQERRAKETEKPSKTRYLKKRSKEQTQPDSPSINTSLYTLSKETKTKTQKHLVSSTCTTSKKKQKETKLSMKQKDMLEHEEKDKEHIYETFISDDEAYDLFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJ03</accession>
    <name>M7PJ03_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcriptional repressor Tup1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01145</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873059.1">
        <property type="nucleotide sequence ID" value="XM_007874868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJ03"/>
    <dbReference type="STRING" id="1069680.M7PJ03"/>
    <dbReference type="GeneID" id="19894842"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01145"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_23_1"/>
    <dbReference type="OMA" id="GTTHMML"/>
    <dbReference type="OrthoDB" id="17410at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000111">
        <property type="entry name" value="Transcriptional repressor rco-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013890">
        <property type="entry name" value="Tscrpt_rep_Tup1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF728">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR TUP11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08581">
        <property type="entry name" value="Tup_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcriptional repressor Tup1 N-terminal" evidence="8">
        <location>
            <begin position="18"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="357"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="392"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="433"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="475"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="526"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="567"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="201"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="223"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="604" mass="66905" checksum="7EB0210EAC7EF2D9" modified="2013-05-29" version="1">MSNLYNHRSTGPSVVSNRLAELLEAVRNEFDNIAQEAMAFRNHKDDYEHKMTSQIQEMQTIRQMVYELEMAHQKMKQSYEEEIARLRRELESRGIHLPTTSTSAQPSLPRLSNPPNLPFPPPNLGLSTNNLSMGRTSHGDLKTCLAPLETNQSVVQLPYPNTGYPSVNNVLPLQSCPQHANKRICSDSGVDNTYNVPKGSNYSAVSGSFSPSSKRNKSHSNRAETSNSFIPVQPSSARSVVPSTPLTTAPQQPSTSVALGQSLSMADIDPDMIPCELKKEDSDWTVLFNPNVPRVLDINLVHTLEHQSVVCCIRFSHDGEYLATGCNRVAVIFDVKTGKRLTVLQDESVDREGDLYIRSVAFSPDGKYLATGAEDKRIRIWDILKKKIRHLFTGHEQDIYSLDYSQNGKFIASGSGDRTARVWDIETGHCILTLSIEDGVTTVAISPDSRYVAAGSLDKVVRVWDAKTGYLVERFEDHKDSVYSVAFSPNGCELLSGSLDKTVKLWELMDAKTSTGPKNGLCKTTFTGHKDFVLSVASSPDGHWVVSGSKDRGVYFWDYHGRAQLILQGHKNSVISVAVSPTGRLFATGSGDCRARIWEYTTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJ08</accession>
    <name>M7PJ08_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Ubiquitin-related modifier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">URM1</name>
        <name evidence="7" type="ORF">PNEG_01150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of UBA4, then thiocarboxylated (-COSH) via the rhodanese domain of UBA4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the URM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873064.1">
        <property type="nucleotide sequence ID" value="XM_007874873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJ08"/>
    <dbReference type="STRING" id="1069680.M7PJ08"/>
    <dbReference type="GeneID" id="19894847"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01150"/>
    <dbReference type="eggNOG" id="KOG4146">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148208_0_0_1"/>
    <dbReference type="OMA" id="DYELQPN"/>
    <dbReference type="OrthoDB" id="10248987at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097163">
        <property type="term" value="F:sulfur carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007114">
        <property type="term" value="P:cell budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01764">
        <property type="entry name" value="Ubl_Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03048">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015221">
        <property type="entry name" value="Urm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14986">
        <property type="entry name" value="RURM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09138">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037379">
        <property type="entry name" value="Ubiquitin-related_modifier_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="modified residue" description="1-thioglycine" evidence="5">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)" evidence="5">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="107" mass="12236" checksum="D1A4F8F1D447A6A3" modified="2013-05-29" version="1">MKDILDITVRFSGGLQTLFGNQNTHHVQLLLSDPVLEGSPPNIAYLIHFLSQNLMNDTRKDLFIKDDTVRPGILVLINNEDWELNNEKYYILQPKDEITFISTLHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJA5</accession>
    <name>M7PJA5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">TATA-binding protein-associated factor MOT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01247</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873168.1">
        <property type="nucleotide sequence ID" value="XM_007874977.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7PJA5"/>
    <dbReference type="GeneID" id="19894944"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01247"/>
    <dbReference type="eggNOG" id="KOG0392">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_1_1_1"/>
    <dbReference type="OMA" id="WYSDIAC"/>
    <dbReference type="OrthoDB" id="10252227at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045898">
        <property type="term" value="P:regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17999">
        <property type="entry name" value="DEXHc_Mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000009">
        <property type="entry name" value="B-TFIID TATA-box-binding protein-associated factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001793">
        <property type="entry name" value="TATA-binding protein-associated factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044972">
        <property type="entry name" value="Mot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044078">
        <property type="entry name" value="Mot1_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022707">
        <property type="entry name" value="Mot1_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498:SF1">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12054">
        <property type="entry name" value="DUF3535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="1282"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="1622"/>
            <end position="1773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR10539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1851" mass="210868" checksum="29F0DFB8C5A9B302" modified="2013-05-29" version="1">MGIKSGGSHLDRLILLLDTGSTQVIRQTAAQQLGSIQKDHPYELYNIFEKLIPYIRSKSWDTRTAAALAINAVIRQVPLWDPNKEDFKHENTFKLLLKEEKCRGMFDDTLNTVFSFETFDISLVIKNGRKLLGSDGKEYDFDSSDFFSEENLSFQKKNLISRLGFGGEYVDDNLFTTSDLTQSINDSFKSSEQEFISSITNNTTLSARQRNVMKRKAKNNAKNTRTNKICITSVPTNVKTEKSEDIVPPELPTIIKQENSSESNLLKSQVEGSCTVIENESSSIIKNLTESLEWPFKKIAELLKIDLFHPQWEIRHGAAMGLLEIIKIHGKGAGRVVGLSRTENNKKNKIWLDDIACKLTCIFALDYFGDYISDQVVAPIRESVSQILAALLIHVDSESVKAVYKILYRLVFQQDIGIENPIWEVAHGGMLGLKYLVAVRKDVVFESNEMFDGVVQAVLYGLKNYDDDVRSVSASILSPIALEFVENKLEAVSDLIKTLWICFSDLRDDLSISVANIMDLLSKLCSFPKVIDIMKRNAILNQSQSFYFLVPKLFPFLRHTITNVRKAVIKALLTLCNLENDKFESWIDGKALRLIFQNMLVEQNIEVLNLTLELWNTIVSLIKSDSDSLRFYVQYSSHLLPTTELLMTPIGVPRHPYAMDVPFLLPFGDSDSSVNFSNENFIKSNVNLRKKQDKNHESIIFYNIDKPMIQGDIDLLGTEVIIQSRLISAKALGFLISRFPKDKINEIINYLLNYFLSPFSTPRFLTAIVFQSFCENIGDKTEFLALIHEKFINILNDPLPSMFANLVPYMRIVRSQCCVLCNTFIGDGNLDPSDIPYISTEIQGEVNASLDAFSLKDAEKLIEDDFNRLQDMILPSYRTKASKVLMEVQKSAKDAIKVVKNAKFLSDVQIMAAIACTLVSTKELPKKLNPVIRAIMDSIKNEESLVLQTHSAESLTRLVDLCILSHPNVIDKLISNLCTFLCLDTSEIPEFYCNRALQKCILSLKKEEDNQCLKEILYEKNSEVHIKKNGAKLVLINIVKTFGENLFEKIPKLYACMFKSIEFAFKEGFDFPKDITERSSILGQNIIDGLSILRILVSYFNKSLYPVVIEHFNIILRALQSEFSVIRYAAARCLAVICNVITVEGMNEVILHALPLLKDADNVIKRQGAVELIYHLVQIMDANILPYVIFFIIPILARMNDSDNDIRVFATSTFAALVKLVPLESGIPNPPGISDELLKNRDSERKFISQILDGSKLEPFSVPSCIKATLRKYQQEGVNWLAFLNRYQLHGILCDDMGLGKTLQSICIISSDHFFKNEEYVSKNIDIRLIPSLIICPSTLLRHWQHEFSTYAPFMRILIYVGNLSERMKLRNSFEKYDVVVTSYDICRNDSEEFSKRNWNYCVLDEGHIIKNAKAKLTKAIKLIKANYRLILSGTPIQNNVLELWSLFDFLMPGFLGTQKSFHEKFAKPIAVSRDSKVSSREQEAGALALESLHKQVLPFLLRRLKEDVLDDLPPKIIQDYHCDLSPIQRQLYEDFARTQVSEVIKHLKGEKIGKKSHIFQALQYMRKLCNSPALVLNSKHPQYEKINLQLRQQNSTIYDIEHSPKLIALRDLLLDCGICMNDDTLGIQVNQHRALIFCQFKDMLNMIEDQVFKKLLPNVSYVRLDGDIDLKQRYEIVQKFNSDSSIDVMLLTTNVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKNVVNVYRLITKETLEEKIMSLQRFKLNIASSVINQQNFGLSTMNTDQILDLFITTQEEQASDSQSANKQSILDSEGNLLQKNQKNIIENLNDLWDPAQYEELYDLDEFILSLPPIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJD9</accession>
    <name>M7PJD9_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873208.1">
        <property type="nucleotide sequence ID" value="XM_007875017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJD9"/>
    <dbReference type="STRING" id="1069680.M7PJD9"/>
    <dbReference type="GeneID" id="19894981"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01284"/>
    <dbReference type="eggNOG" id="ENOG502SC4N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1215203_0_0_1"/>
    <dbReference type="OMA" id="WNIGLEI"/>
    <dbReference type="OrthoDB" id="2159786at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053029">
        <property type="entry name" value="RNA_pol_I-specific_init_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007224">
        <property type="entry name" value="TIF_Rrn11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04090">
        <property type="entry name" value="Rrn11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="228" mass="27115" checksum="7DB975B3DF566012" modified="2013-05-29" version="1">MFLLPISRKIHKKQPKVLKEIYMKINIGPETLLNKKFEESKKIYSIRKHQIKALHTILHLSLLRGEFSDAHYAFSILIRCREIRLYDIWDIGLEILRHIDPDQQERYLKGLIAFYQTPIRSDSSKDKVGEELLKALILLYIEKEEFEKLLNILEDYLLSAPYSENSSFYEYAGMAALELSEKTTITTERKQFYERAEYMFQKAREKNKSISYRNVFNMFSNKNGKIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7PK27</accession>
    <name>M7PK27_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Splicing factor U2AF 23 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00932</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872844.1">
        <property type="nucleotide sequence ID" value="XM_007874653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PK27"/>
    <dbReference type="STRING" id="1069680.M7PK27"/>
    <dbReference type="GeneID" id="19894630"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00932"/>
    <dbReference type="eggNOG" id="KOG2202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059852_1_0_1"/>
    <dbReference type="OMA" id="MIDTRQA"/>
    <dbReference type="OrthoDB" id="423462at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000066">
        <property type="entry name" value="Splicing factor u2af 23 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="44"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR10784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="208" mass="24252" checksum="D32A850ABF8A978A" modified="2013-05-29" version="1">MASFLASIYGTEQDKVNCSFYFKIGACRHGDRCSRKHVKPSYSQTILCPNLYQNPAHDQHNQLNEQQIAQHFDSFYEDMYAEFCKYGELEKVVVCDNVGDHLIGNVYARFKYEEDAQKAVDSLNSRWYAARPVYAELSPVTDFREACCRQHETSECMRGGFCNFMHSKKPSPALLRDLELSQRKYLRLQGKDRSPTRSPSPIRRDRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M7PK47</accession>
    <name>M7PK47_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00956</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with ODC and thereby sterically blocks ODC homodimerization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ODC antizyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872869.1">
        <property type="nucleotide sequence ID" value="XM_007874678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PK47"/>
    <dbReference type="GeneID" id="19894654"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00956"/>
    <dbReference type="HOGENOM" id="CLU_1215202_0_0_1"/>
    <dbReference type="OrthoDB" id="5369127at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008073">
        <property type="term" value="F:ornithine decarboxylase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075523">
        <property type="term" value="P:viral translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002993">
        <property type="entry name" value="ODC_AZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038581">
        <property type="entry name" value="ODC_AZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02100">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0688">Ribosomal frameshifting</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="228" mass="25455" checksum="0BE147624B3F8980" modified="2013-05-29" version="1">MAHNNTVYYLNSQEIDLDNEILMSPCSKVLDNDMEYNYYDTVSLTCTVTPLKQPNSSGVPEVLCEYSPPASAGASLDVLSSASGKYDTAGFSRSSSLESESGFSVLRERLICGVWWKEFGIEGNDVVESVSINENNKVLCRGITTFSKNKRNIYIIGDICNKPYLKQRLVAIIDFASIFLFCNELFIRIKKLSSGLESLVKGLIWIGFRIVPSASFSSEYYLLLSIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7PKZ9</accession>
    <name>M7PKZ9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872641.1">
        <property type="nucleotide sequence ID" value="XM_007874450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PKZ9"/>
    <dbReference type="STRING" id="1069680.M7PKZ9"/>
    <dbReference type="GeneID" id="19894438"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00740"/>
    <dbReference type="eggNOG" id="KOG1763">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042870_2_0_1"/>
    <dbReference type="OMA" id="HYHEDAN"/>
    <dbReference type="OrthoDB" id="278280at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681:SF0">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681">
        <property type="entry name" value="ZINC FINGER-CONTAINING PROTEIN P48ZNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="175"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="175"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="243" mass="28455" checksum="7BE1ED2B54BE2EBE" modified="2013-05-29" version="1">MPQKKTAPSVKKNPQKIVEDKTFGLKNKNKSSKIQAHIRQIESQAANIGKNKITKEKEMQKKEQTEKKIAEESRKMELSELFKQPPQKVPFGVDPKSILCQYFKQGFCDKGKKCKFSHNLDVEKRSEKKDIYTDSRLIHLNENKSLIDKKNDTIDLWDDEKLQSVVLSKHGNPKTTTNIVCKFFLEAIEKGIYGWFWVCPNDGDNCKYKHRFIILIFFLRLKYIIAFHLDLFSKISKKIKKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7PLH9</accession>
    <name>M7PLH9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-splicing endonuclease subunit Sen54 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00323</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872196.1">
        <property type="nucleotide sequence ID" value="XM_007874005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PLH9"/>
    <dbReference type="STRING" id="1069680.M7PLH9"/>
    <dbReference type="GeneID" id="19894021"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00323"/>
    <dbReference type="eggNOG" id="KOG4772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028449_0_1_1"/>
    <dbReference type="OMA" id="FNVWKPQ"/>
    <dbReference type="OrthoDB" id="408683at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032473">
        <property type="term" value="C:cytoplasmic side of mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024337">
        <property type="entry name" value="tRNA_splic_suSen54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024336">
        <property type="entry name" value="tRNA_splic_suSen54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12928">
        <property type="entry name" value="tRNA_int_end_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen54 N-terminal" evidence="3">
        <location>
            <begin position="57"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR11294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="364" mass="42607" checksum="5460823353C165BF" modified="2013-05-29" version="1">MSSDFDIEDEIQDFSLLSDYKRNISNTVFLKRGEKDFEPDGTFKQQEVLRNRINSMFNVISGERCISKKIYSKAIWVSDLKLARVERMRGTQFKSLGKCVNDVVWLLPEEVIYLVERGSLECWWENGIPMSLQAVYSACLEESGGIERYQVYSYLKRLGYYVFRPVKCENGVSRFSFLVSYGSEKISPFFLWMKALIRFVYSIFEKYTANNWNTLVGGRCYHSYNQIYKSLEIIPYHCPPSSEENYIYDENKAKDPFSIAYYVWKPIPNFRKSKLENPDFRIIVVNSRTTSLPSLKEFSDIFDSVPLINYEKNTTAFQRLKNGARHIIFALIDSGAISFIKFMDIGFGNEKMYIKDDTHKKIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7PMZ7</accession>
    <name>M7PMZ7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00253</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872124.1">
        <property type="nucleotide sequence ID" value="XM_007873933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PMZ7"/>
    <dbReference type="STRING" id="1069680.M7PMZ7"/>
    <dbReference type="GeneID" id="19893951"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00253"/>
    <dbReference type="eggNOG" id="ENOG502QRAF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_359846_0_0_1"/>
    <dbReference type="OMA" id="NGIHATI"/>
    <dbReference type="OrthoDB" id="5598057at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13311">
        <property type="entry name" value="PH_Slm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046868">
        <property type="entry name" value="BAR_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046869">
        <property type="entry name" value="SLM1/RGC1-like_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043453">
        <property type="entry name" value="Slm1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941:SF16">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE-BINDING PROTEIN SLM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20400">
        <property type="entry name" value="BAR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20399">
        <property type="entry name" value="PH_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="322"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="568"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="577"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR11829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="778" mass="87572" checksum="5D15F1506F2347C4" modified="2013-05-29" version="1">MGFPETAVLRSRSESNQEKLPDMSLALKENLSRDAHYNNLDSIFSSSFSKNLDPTKNLASRFSSWKVLLKELVIYFKAVINIEEVKANEFKKLGSILNIHSNEKSFQDGGIQEVEKVFCEWNRKYSTHLSMIPGSVNQEIILKLEKLRVMLSERVKDISKMSSQFRNNLSKEADTTKKLMEIYKQSLLRWESSPYQITPRTDPYIIKLSLEKQIAQTLLEENALQQAYLNIENYCRNIERSVINTVREVFSEYKDILQREVSFISDFNKNIVTADDSISLDKGWNNFLREDSSSSNPKDSVNFRKLRYFCDLLYAQNHPAVKEIRSGFLQKRTRILKSYNSRFYVLTASGFLHQFKSDNLSSDQIPQMSLCLRECEICEHSSADSQKYKFSLKGSKNGSSGRIHTFVFKTNTYDDMIDWYNDIKKFTGLLNMPENEFRDYIVALQVGNSVDGQATDIPNDASDQEKKFSLVLKDDFKDDVDIMTSVSSAFYETKSSVHNGQMDHTANKECITNENGDLNKNSSFSGENKISVCINGDITSGQEKSEKDVLTDTSALLNTSGTCVNDSTDLKDTTFGSSSNSSYSSTNEYSCPMDIQNSPPNHKSDLGKPVVDTQKNSNQRDRSCSLHPVLEPQVNNSQGLCSSLSYPGLSQSPLSATTQSKFKEDLGQAALSNLDVSDISDNKLDSEQLQCSKNIGSVNGADNISGMPSDKALDSAELCSRKSIVESECQLPSAVSDSEVLGKSNHKELKENLKVLDNNDYLTKELHKSDKDVPSKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWW2</accession>
    <name>A0A0W4ZWW2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tim44-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_04324</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="KTW32864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874280.2">
        <property type="nucleotide sequence ID" value="XM_007876089.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWW2"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZWW2"/>
    <dbReference type="GeneID" id="19895979"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04324"/>
    <dbReference type="OMA" id="CAQADMQ"/>
    <dbReference type="OrthoDB" id="19619at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024621">
        <property type="entry name" value="Mba1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051975">
        <property type="entry name" value="mtLSU_mL45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L45, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07961">
        <property type="entry name" value="MBA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KTW32864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="32971" checksum="247E966DB0C9F04D" modified="2016-03-16" version="1" fragment="single">MVSKLYKRLNFWMKVGTGGSFRIYEDSVRLYMKKCIEMRFVFKRKIHRPLIQKHMMIPEDLGMLDVYIAPSRSCLPSFWKTPGQRIRLAWRWFYHQIMGWFQKKLFEERIRPVRIDFKQLQLTIGKFYEKVNQAYANGDIKEIDSICGKAYAKTLKSQIAKRPEALRFKWVLHRMIKPPKLVSFSQAQVEIDSNKYLAQAVYRIHSEQSLTIFSDGLKKEEFLKEFIEYYVFQYKTWVLPYKWYIWGKTVEASPDAIKVKLWKKDGKSVRTVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWX7</accession>
    <name>A0A0W4ZWX7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_04315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="KTW32872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874523.2">
        <property type="nucleotide sequence ID" value="XM_007876332.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWX7"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZWX7"/>
    <dbReference type="GeneID" id="19896205"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04315"/>
    <dbReference type="eggNOG" id="KOG2496">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2852">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DDTVYAC"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF150">
        <property type="entry name" value="OXIDOREDUCTASE TDA3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KTW32872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="363" mass="39636" checksum="6889FA70A2928896" modified="2016-03-16" version="1">MTKQSIVIIGGGIIGSTTAYYLTSHSKYDSSRMSITLIEGTGIASGASGKAGGLLALDWHGQETAPLAKLSYELHETLAKEHDGEKKWGYRKLDTLQITSSFRPRRSAALPGTLDWIDAEKIERVSILGTTFTTAQVHPYNFTNTIFSLAQEKGVRLILGTVLPLDDIKTVRYIPKGESFVQTISADYVLITAGPWTGRIYPGIPISGFRSHSIVVTIDKPLSAHALFTHMKLENGQFVSPEIYARKDELYICGETDNEPLPSTTEDVQVKDSSCEQLKKWGDELSRFIKNGHVKTKQACYLPVCTAHTNGPLIGKVKDGLYVGSGHGCWGICNGPGTGKVLSEILLDGEATSIDIRKLNFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWZ5</accession>
    <name>A0A0W4ZWZ5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4536 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_04302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="KTW32898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613371.1">
        <property type="nucleotide sequence ID" value="XM_019757820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWZ5"/>
    <dbReference type="GeneID" id="30671586"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04302"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KTW32898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="9052" checksum="35417B1178500557" modified="2016-03-16" version="1">MTEKNTGEILEKNQCFSCKLTSILTFGILGIYILYQGRKKYRHCKLFIKSGCFQNLNLLLKKKKIQICSFVSWDIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NHP7</accession>
    <name>M7NHP7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_03533</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875625.1">
        <property type="nucleotide sequence ID" value="XM_007877434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NHP7"/>
    <dbReference type="STRING" id="1069680.M7NHP7"/>
    <dbReference type="GeneID" id="19897220"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03533"/>
    <dbReference type="eggNOG" id="ENOG502R6VN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_900649_0_0_1"/>
    <dbReference type="OrthoDB" id="5598695at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000087">
        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWIRM" evidence="3">
        <location>
            <begin position="198"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="287" mass="32864" checksum="548FF27A06AC3C63" modified="2013-05-29" version="1">MLFSPPEIHSGFSRWSEPKLSNTLCKLYHHGFIIPSPPPSPKENVTSLNETKTDNIEIKKKEEGEKEGLSSATFVARVFDLYKNDPRGMLRNERKWLAYHMPSSGIEGQKKRVRSSQGVVRRTVSTSGCRTTSTVRGVGKTKTQFFSIGMPNYKPKQSSKEHYMHTHSFDVANTPYELLPDFCPPTSTLDKINHPRPLRAEWKGIPLDLSNDPHVDQLHPAEVYLASQLRLPAMVYLDNKRRIFAEYHARKEAGLGFRRTDAQRCARIDVNKASRLWQAFERVGWLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJ16</accession>
    <name>M7NJ16_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein LTV1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_03079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTV1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875135.1">
        <property type="nucleotide sequence ID" value="XM_007876944.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJ16"/>
    <dbReference type="STRING" id="1069680.M7NJ16"/>
    <dbReference type="GeneID" id="19896766"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03079"/>
    <dbReference type="eggNOG" id="KOG2637">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028555_1_0_1"/>
    <dbReference type="OMA" id="TAQHFTL"/>
    <dbReference type="OrthoDB" id="5852896at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007307">
        <property type="entry name" value="Ltv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531">
        <property type="entry name" value="LOW-TEMPERATURE VIABILITY PROTEIN LTV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531:SF0">
        <property type="entry name" value="PROTEIN LTV1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04180">
        <property type="entry name" value="LTV"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="41361" checksum="C9F6DF4BDDED46C2" modified="2013-05-29" version="1">MLDVIKMPRKRFIDKKNSITFHLVHRSQKDPLIHDDQAPSRILVPAFYSNKKKISNGLNMIEKSQENISLEKNNNESLKKDEGVENLRENVGEAILYGISYDDTKYDYMQHLRGIGKSPGTILLQRPIDKKLSIIDELPKEVFPSDTEQKRSYRDQQSIPDDISGFQPDMDIRLREVLEALEDDRYLSSDEDGDLDELIKSGKADDSSVIENLDTDWDSDDTKISKEILSQDLHTYNNDSIFRECLKNKKKKFRKPLSTATYSSISSSILPRSEALMLLDDRFEKIKKEYDDDISDKESKGDSERMDFESIMDNFLDNYEIVGKKIVPKIYSKEFNIKHSKPMTELDEIRQLRTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJL0</accession>
    <name>M7NJL0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02953</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM208 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874998.1">
        <property type="nucleotide sequence ID" value="XM_007876807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJL0"/>
    <dbReference type="STRING" id="1069680.M7NJL0"/>
    <dbReference type="GeneID" id="19896640"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02953"/>
    <dbReference type="eggNOG" id="ENOG502S72U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1661531_0_0_1"/>
    <dbReference type="OrthoDB" id="10012212at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008506">
        <property type="entry name" value="SND2/TMEM208"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505:SF7">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05620">
        <property type="entry name" value="TMEM208_SND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="159" mass="18689" checksum="B1E1E03947F377C9" modified="2013-05-29" version="1">MANASLKKQARKNKTAIRTLKIGGILSNLFFISIRLIYYYPSTTKYTFIFYFISCFLSTALSFLLWSMGSPKSEKKSLHSFEDLNQKGLVAYMFYTIYITWVVYVFTAIFTDKAWLLYLIPCFLLSSHLLSIIKLFFMNKYIKIEQESINKKVKYIHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJZ2</accession>
    <name>M7NJZ2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial aspartate-glutamate transporter AGC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Aspartate-glutamate carrier 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PNEG_02723</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Calcium-dependent mitochondrial aspartate and glutamate carrier. Transport of glutamate in mitochondria is required for mitochondrial transamination reactions and ornithine synthesis. Plays also a role in malate-aspartate NADH shuttle, which is critical for growth on acetate and fatty acids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer (via N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874749.1">
        <property type="nucleotide sequence ID" value="XM_007876558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJZ2"/>
    <dbReference type="STRING" id="1069680.M7NJZ2"/>
    <dbReference type="GeneID" id="19896414"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02723"/>
    <dbReference type="eggNOG" id="KOG0751">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014931_2_0_1"/>
    <dbReference type="OMA" id="AFQNVMR"/>
    <dbReference type="OrthoDB" id="2161at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000004">
        <property type="entry name" value="Calcium-binding mitochondrial carrier protein Aralar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF9">
        <property type="entry name" value="CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="97"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="169"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="344"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="442"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="540"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00082232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMR08943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="674" mass="77380" checksum="0F348259EDCD89EE" modified="2013-05-29" version="1">MFLELQSIFERIISVFSDKSRSLENHYKFVFEKYATVEKYGELYMNVEDFVNAITSEGECHKIKRDEYCILFRVADVKKKGLLSLEDWICFEKLLAKYDAEYEIIFKFFDINGTGKISYEDFKKIISTNKCSDSIPFNWNTSWSKIYMSNVRKYNMMTYPEFIQMMKDLEEERIRQAFVYYDKENLGYIGLDEFSKIINKLSWHKLSDYLLTHLHTLCNMVSGQKISYANIRAFHNVIGKMNMIERIVRTATLNSPDSRITKIDFMREAEKMGCSSLFTPMEMDILFHFSSLDNDTGRLSYQDFIKILDVSWKNSVEQKNILSCDELKIVNKYGKIKKLLPNLLDSIYHFSLGAVAGASGAIVVYPIDLVKTRMQNARIRIGEQMLYRNSFDCAKKVLRNEGIWGLYSGVGPQLIGVIPEKATKLTVNDLVRNIVKEDNGKIKLYWEILAGASAGASQVIFTNPLEIVKIRLQMQGEHIVSSKDAFRKNALFIIRDLGLSGLYKGTSACLLRDIPFSAIYFPVYSHLKNDYFKENSGKKLKIFEHLVSGAIAGIPAAYFTTPADVIKTRLQVEARKGETTYKSIRHAFFTIIKEEGVSTLFKGGPARVFRSSPQFACTLAVYEALQSLFSKSTHSSQLLFDSKEKNVSLPYLRSCNALHTILDMDINYGNYFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7NK64</accession>
    <name>M7NK64_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Histone acetyltransferase type B catalytic subunit</fullName>
            <ecNumber evidence="3 9">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_02796</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HAT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 9"/>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874829.1">
        <property type="nucleotide sequence ID" value="XM_007876638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NK64"/>
    <dbReference type="STRING" id="1069680.M7NK64"/>
    <dbReference type="GeneID" id="19896485"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02796"/>
    <dbReference type="eggNOG" id="KOG2696">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036024_2_1_1"/>
    <dbReference type="OMA" id="WTCDAND"/>
    <dbReference type="OrthoDB" id="10253098at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043997">
        <property type="term" value="F:histone H4K12 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043995">
        <property type="term" value="F:histone H4K5 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043996">
        <property type="term" value="F:histone H4K8 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.360.10">
        <property type="entry name" value="Histone acetyl transferase 1 (HAT1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019467">
        <property type="entry name" value="Hat1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037113">
        <property type="entry name" value="Hat1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017380">
        <property type="entry name" value="Hist_AcTrfase_B-typ_cat-su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013523">
        <property type="entry name" value="Hist_AcTrfase_HAT1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12046">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21184">
        <property type="entry name" value="HAT1_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10394">
        <property type="entry name" value="Hat1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038084">
        <property type="entry name" value="HAT-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histone acetyl transferase HAT1 N-terminal" evidence="13">
        <location>
            <begin position="9"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="11">
        <location>
            <begin position="199"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="219"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with histone H4 N-terminus" evidence="12">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR09023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="396" mass="47586" checksum="083F554700F4D7A2" modified="2013-05-29" version="1">MEVFKEKNYSFNAKDVIFIEIANINETKMPIIFHPIYTYSIFEEERITGYKDLNINLKFCCHDLQIYLKIQYTDKAENKEHLSCKNIEETLRKYLPKTIMTDETTFYSYLRDNKSFVPPGNKISSYMLNNSVFEVFMGSIVDPEIEKIVNNMQIFSLFLIEGASFIDIEDSKWMIFLLYEKQSRNDQDYYCFIGYSTVYLYYWYSRESLDNSRARIAQFVILPPFQRNGHGGKLYDALYTYILSNSKIQEITVEDPSDEFQDMRDKQDIIRLKISGIFNEKEFKPPIPYLWILEAQKKSKISLNQFFRCIEIALLERLNIRDEKAYKEYRLQIKQRIYKKNFENLNQYNKDEILKKLEETYKSIEKDYLRIIKSMKAHKCKEQDGSNRIKRKEIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLH3</accession>
    <name>M7NLH3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Probable proline--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_02101</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874081.1">
        <property type="nucleotide sequence ID" value="XM_007875890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLH3"/>
    <dbReference type="STRING" id="1069680.M7NLH3"/>
    <dbReference type="GeneID" id="19895795"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02101"/>
    <dbReference type="eggNOG" id="KOG2324">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016739_0_0_1"/>
    <dbReference type="OMA" id="NCDYAAN"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00779">
        <property type="entry name" value="ProRS_core_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000042">
        <property type="entry name" value="probable proline--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050062">
        <property type="entry name" value="Pro-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033730">
        <property type="entry name" value="ProRS_core_prok"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME PROTEIN L39/PROLYL-TRNA LIGASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753:SF2">
        <property type="entry name" value="PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="99"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR09513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="587" mass="68356" checksum="86B05E13F88029B4" modified="2013-05-29" version="1">MKDIFFSRLIFLKKIKMLIKISYHNRNSIRNPSRYHSFPSYLFFNSCILFFSHKRFNFISTHSRPCLSNIFIPHGISCQNSQKIDKSGHDLLIKAGFLRQSSSGIYTILPLALRVQEKIENIIDTSLYKINASKISLPNLSTSYLWKKSRRWDLLGNELFRLKNRRGTEYCLSPTHEEEITNLIATEISSWRQLPLKLYQTGKKFRDEIRPRRGLLRGYEFIMNDLYTFDKSKEDALQTYKLICDTYKEIFSKLELPIVMAEANNGNIGGDLSHEFHIIFSCGEDTLIICKSCGYISNEEFTHVKLKFQIPFKLENCNCFYIKDINDIIIGIAYVPIDREINLLLVNKMMKSINSEIFTITPNTDVKRGTKNHYKNEIIHILDENFNPNSFTYPNHLKCFRNRLITASIIKSRKKDLCYKCSKPLISQKSIELAHTFYLGTKYSSALSATFTSEKDNNILPIEMGCYGIGISRILSSIAEINKDDKGLIWPITIAPWKAVIISTSDLDHMLYKVYDMIFCYFEKDSIIIDDRKNKGFIWKMKDSDLIGFPYTIIIGRHWKETGELEIQIRKTGEKIFVKPENIKNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLH7</accession>
    <name>M7NLH7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="17">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PNEG_02104</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="16">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="17"/>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09518.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613300.1">
        <property type="nucleotide sequence ID" value="XM_019757738.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NLH7"/>
    <dbReference type="GeneID" id="19895798"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02104"/>
    <dbReference type="eggNOG" id="KOG0204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_9_3_1"/>
    <dbReference type="OMA" id="MINVHDI"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 17" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="517"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="562"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1009"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1042"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1083"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1116"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1157"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1191"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="19">
        <location>
            <begin position="385"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="20">
        <location>
            <begin position="1036"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00059328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EMR09518.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1371" mass="153846" checksum="E087A68BA7C92781" modified="2016-03-16" version="2">MDEDIKKQVPVVMIDTSNVPISTSSEDQNRNDQGSRGSDQNSCVDSLVQYDCFTQCDTSTQYLSRNSWDMSTATSCIARKALYSYAFREMALRTLAIRGSGRKGPFAFTAEQLEVLVDPRNVEILRIIGGIEGLCLGLHTDPILGLNVDEKCVAKEVTLKDLMSTDDYLMYEKMCQDYKIECQNLKSKDNVKKKCMFWKKKKMEFSPSNSLFMKKKFSEKTNCMKLYFKKFFHCINMIYNAILRILCFIPKLMLKIKFIRVLKEVFIGKSESYKEFLSLYGESFKTRISVFGINRTPKRHIKGIIPLIFNVFKDSILILLLCSTIVSFGIDIYFGLVHSNDDESYNSNVDGIAMLVAIAVISVVSAVNDYQKEVQFEQLNAKKENHDVRVIRSGKPIFISVYDLQVGDILLFELGDLLPADGILIDSYNLCCDESSTTGESDAIEKVSCSVCLENTSPDVIFDEKYDPFMISGSKVVEGTGKYIVTSVGLHSYYEKIMVSIQTELDSTPLQIKLSKLAIGISKFGICVSFSLFVILFCRFLVYLVDNKITIYEKATNFMKILIVSITILVVALPEGLPLAITLALAFATRKMSKENNLVRHLRSCETMGNVTTICSDKTGTLTQNKMTLVVGIIGLSTQFRDNFDSEIDENTSEMVTLEASSLLKSLNPSVTQLIIQSIVVSSTAFLATDKQGKTSFLGSKTDCALLEFAQKYFNMDDPSIERAKVDVLQFIPFSSSRKYMASIISLPNGGARLYVKGASETLLEYSSYVLHEPLSRKSDTLSVLPLTQEGKDLIYKTIVRYATHSLRTIALVYKDFDVWPDHNLQNSITGSEINFNSIFSQMIFIGVLGIMDLLREGVKDAIETCKKAGITVRMVTGDNKITASAIARLCGIYTPGGILMEGVDFRNLSSEDMDMIVPKLQVLARSTPEDKKILVTKLKELGEIVAVTGDGTNDGPALKKADVGFSMGISGTDVAKEASDIILMDDNFSSIVKACAWGRTINLAIKKFLQFQITVNITAVFLVFVTAITDSEMRSVLTPVQLLWVNLIMDTFAALALATDPPNSTILNRKPEPKTSLITFEMWKMIIAQSIYQLLVMLSLRFWGGTIFRYNNERAYMFDTLPTLIFNVFVFMQIFNELNCWRLGNDVNIFEGIRSNPWYIFINLIMISGQVIIVFYGGKAFQVSPLNLEQWGISIFLGALSVLVFILVRHIPDRFLMKIIPLSFKQSLLKSDNSFSNSQTQWDLASLQVKDELVFLKALKNRYTVDYSRRTQEMNRFYEKLTQAIHITGEDTEKVKDLLSKQNFQFFVTPSLRAATLAPAIMAGSIGGCISSGLPQTAVFNDSLRDRGVELYSFAQSDKTTNTFDQNFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLV8</accession>
    <name>M7NLV8_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874220.1">
        <property type="nucleotide sequence ID" value="XM_007876029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLV8"/>
    <dbReference type="STRING" id="1069680.M7NLV8"/>
    <dbReference type="GeneID" id="19895928"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02235"/>
    <dbReference type="eggNOG" id="ENOG502S2YR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_894646_0_0_1"/>
    <dbReference type="OrthoDB" id="5367584at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024312">
        <property type="entry name" value="TACC_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12709">
        <property type="entry name" value="Fungal_TACC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="136"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="259"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="311" mass="35999" checksum="920341955A76510B" modified="2013-05-29" version="1">MSGNHIFIKKSNTSPPKIDSFSKRNSSFEEKTHCQAKHNELCIENGIKNLSDKHKNQSFSKGEIDTPNRTLSTPNSQKPSHNLLLSFNSPTVPFVTSSMKLPPLPPSTPTETQKLLLDMSPEPVFVTPRSIPKYTLHDLEKERSKLRTEIVNLESQLRGREAEINELRMHVAKIENIVSIMEREKNDLIISWEKERLEFKNLASLSADSKTTSPIIDQALLTELETKHQEQLTNLANDLHRQYSQKHHQKVQALKISYEKKYEAKINTLQEKLEETNRMLENEQKEKMEIISMSEELMKVMEERGEKEQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7NM04</accession>
    <name>M7NM04_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rnh202 triple barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875424.1">
        <property type="nucleotide sequence ID" value="XM_007877233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NM04"/>
    <dbReference type="STRING" id="1069680.M7NM04"/>
    <dbReference type="GeneID" id="19897032"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03345"/>
    <dbReference type="eggNOG" id="KOG4705">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2400617_0_0_1"/>
    <dbReference type="OrthoDB" id="29098at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040456">
        <property type="entry name" value="RNase_H2_suB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041195">
        <property type="entry name" value="Rnh202_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383:SF11">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17745">
        <property type="entry name" value="Ydr279_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rnh202 triple barrel" evidence="1">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="93" mass="10783" checksum="0C4E59BAEB3F2F58" modified="2013-05-29" version="1">MTKIIIKPRNFLNGKTTEEQIIALPHPKTQIPVRYLIQKPQLLQLIKVNDSYKKGSWFINNNIVKDGTIYLATPFDLVFLAIPVLEETYKEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2024-01-24" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M7NM37</accession>
    <name>M7NM37_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873894.1">
        <property type="nucleotide sequence ID" value="XM_007875703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NM37"/>
    <dbReference type="STRING" id="1069680.M7NM37"/>
    <dbReference type="GeneID" id="19895612"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01918"/>
    <dbReference type="HOGENOM" id="CLU_2016215_0_0_1"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="14427" checksum="D50F6901D2E2557A" modified="2013-05-29" version="1">MSFETSQQAVVRLTLGLTEKFKKHISQQEKLAKNRVKNKKYYKNNISEDKFDESLKYQSFESVFIQEKSLKTNILIDRYELKSFIGAGAFSCCILAVDKLRPDQPFRVIKKMNQTYEEFGLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NM48</accession>
    <name>M7NM48_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_01928</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873904.1">
        <property type="nucleotide sequence ID" value="XM_007875713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NM48"/>
    <dbReference type="STRING" id="1069680.M7NM48"/>
    <dbReference type="GeneID" id="19895622"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01928"/>
    <dbReference type="eggNOG" id="KOG3106">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057784_0_0_1"/>
    <dbReference type="OMA" id="WKSRSCE"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045015">
        <property type="term" value="F:HDEL sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00951">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00952">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR09743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="212" mass="24885" checksum="20409B789760E869" modified="2013-05-29" version="1">MNLFRFLGDLSHLASVFILLQKIRKSRSCSGISFKSQVLFSIVYLTRYIDLFLNYVSFYNTLMKIFFIASQSYIIYLMKGPFKPTNDPNIDTFKIQYLIGGAAILAIISPSRYTFLEIFWCFSIWLESVAILPQLLMLQRTGEAESLTTHYLFCLGLYRGFYIPNWIYRYITERFYDIVAIIAGLIQTGLYADFFWLYYTKVLYGKKFELPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMB5</accession>
    <name>M7NMB5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylglycerol/phosphatidylinositol transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_01984</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873964.1">
        <property type="nucleotide sequence ID" value="XM_007875773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMB5"/>
    <dbReference type="STRING" id="1069680.M7NMB5"/>
    <dbReference type="GeneID" id="19895678"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01984"/>
    <dbReference type="eggNOG" id="KOG4680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1525806_0_0_1"/>
    <dbReference type="OMA" id="QTIFPRN"/>
    <dbReference type="OrthoDB" id="6409159at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF0">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL_PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082286" description="Phosphatidylglycerol/phosphatidylinositol transfer protein" evidence="8">
        <location>
            <begin position="22"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="9">
        <location>
            <begin position="35"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR09803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="176" mass="20365" checksum="F2A8DC03D7E663F1" modified="2013-05-29" version="1">MKVYVITLILLLCKHFSRIRANNEIKNVSQERSIISFCPYTNPETYILQIKSLKIIPNPPQRGSQFIVEGQGTLNEDVLVGSYVLLSVTYGIIPILNMRIDLCEQTRKVQFPCPISKGEYQATREFYIPSSIFPGRYIIKADAFLENNKRIACFIVDITFIPKFFLKQLYFNNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMH3</accession>
    <name>M7NMH3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDENN FLCN/SMCR8-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875219.1">
        <property type="nucleotide sequence ID" value="XM_007877028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMH3"/>
    <dbReference type="STRING" id="1069680.M7NMH3"/>
    <dbReference type="GeneID" id="19896844"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03157"/>
    <dbReference type="eggNOG" id="KOG3715">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035854_0_1_1"/>
    <dbReference type="OMA" id="THFCDKH"/>
    <dbReference type="OrthoDB" id="5599713at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037521">
        <property type="entry name" value="FLCN/SMCR8_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021713">
        <property type="entry name" value="Folliculin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037520">
        <property type="entry name" value="Folliculin/SMCR8_longin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31441:SF2">
        <property type="entry name" value="FOLLICULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31441">
        <property type="entry name" value="FOLLICULIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11704">
        <property type="entry name" value="Folliculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51834">
        <property type="entry name" value="DENN_FLCN_SMCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN FLCN/SMCR8-type" evidence="1">
        <location>
            <begin position="56"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="281" mass="31913" checksum="FCF28ACE15780683" modified="2013-05-29" version="1">MILSLAHFCEIHGPTAIFCTQAISSHHETSFVDFMEDNKNGNSSEGVLLREEACASCQFSVPTDLTVHKNGFPILKTQSSDHKVLYISTRRPIFVHENSALKHACVRSLSCELLPGKTGPILFGDATFGYTIAYVFRLADPYARGLKRWYSFICLMQNQTNLSRAWRFIIEKFEILVHRLDTKSKMVLVGIDGGNIQGNSVEVKRSPEGFLRKYDSSSMPQSLAKLVDMQDIFVQIHASFAWILSIWGIQFERSSKNNYSEFKNLIEMKPRKDESEKGEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMN4</accession>
    <name>M7NMN4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mannose-1-phosphate guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01701</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873665.1">
        <property type="nucleotide sequence ID" value="XM_007875474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMN4"/>
    <dbReference type="STRING" id="1069680.M7NMN4"/>
    <dbReference type="GeneID" id="19895395"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01701"/>
    <dbReference type="eggNOG" id="KOG1322">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_0_0_1"/>
    <dbReference type="OMA" id="GPNCWIC"/>
    <dbReference type="OrthoDB" id="1733332at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06425">
        <property type="entry name" value="M1P_guanylylT_B_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000013">
        <property type="entry name" value="mannose-1-phosphate guanyltransferase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045233">
        <property type="entry name" value="GMPPB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="9">
        <location>
            <begin position="2"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="10">
        <location>
            <begin position="253"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="362" mass="40314" checksum="564B7CA4940CFB10" modified="2013-05-29" version="1">MKALILVGGFGTRLRPLTLTLPKPLIEFGNRPMILHQIEALVSSGVTDIVLAVNYCSDIMVSTLKQYEQQYHIKIVFSVENEPLGTAGPLALARDILEKDHSPFFVLNSDVICEFAFSDFLHFHKQHGAEGTIIVTKVEEPSKYGVIVMKPASSEIERFVEKPAEFVSNKINAGIYVFNPSVLKRIPLRPTSIEKEIFPAMANEGQLHSYDLEGYWMDIGQPKDYLTGTCLYLSSLAKNKPSYLDHTSSYIYRGNVIIHPSAKIGINCRIGPNVVIGPDCTVGDGVRLQRCVIFQGSRIQNYAWIECSIIGWNSTVGKWARLENVTVLGEDVTIKDEIYVNGGSILPHKCIDQNIEVPSIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMX5</accession>
    <name>M7NMX5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_03058</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875114.1">
        <property type="nucleotide sequence ID" value="XM_007876923.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NMX5"/>
    <dbReference type="GeneID" id="19896745"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03058"/>
    <dbReference type="eggNOG" id="KOG0996">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001042_4_1_1"/>
    <dbReference type="OMA" id="CPALDNM"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000481">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000585">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF172">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="14">
        <location>
            <begin position="688"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="430"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="616"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="921"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1034"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1144"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR08582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1356" mass="156570" checksum="847ABFC03CD0216B" modified="2013-05-29" version="1">MVRPSRNTRANFPEKKRCYGRIVGSSESETENENNKEQRDITRSPITSTSVASMTSSPMSALSPKKEDNLTMEFSSLKMYTSPDKTKEKDIKIKQGPLSSKVKRVPLVQLSSLSQNSPIQKLSSISPAKLGLSNQLILSEQAVNDSKQIERLMISQLVLTNFKSYAGRQCIGPFHPSFSSIVGPNGSGKSNVIDALLFVFGFRASQMRQSKISALIHKSLAYSDLDFCSVEIYFEEIQEIENSNSSSVSYIIKPESRMVISRKAFKNNTSKYMVNDRESSYTEITKLLKEKGVDLDHKRFLILQGEVESIAQMKPKAPNDHEDGLLEYLEDIIGTSNYKKRIEETSIKLDRLNELCEERLNRVSVVKKEKDNLESRKEIVLSYIRDDNILTMKQSKLYQAYIFECDANIEATKEHIKKLREIIDADEFMYKENSKKIKELEKQHEKILKEHENLEIDLLNAQKEFTKYDQENIKLQEKQKHLLQKQKKNNTLIQTNSHSYLEAVRSIENCANQITSCEKEIFELTNRLQLETKELEKIRYELKDKTHDISDQLEIKQKKLDPWIEQINNRQSKIDVINSEIKILVDKENRSVQEIHNIQKRIRTIEEEETIAKETIQQCRIDKENKERELLYAKEEYEKMKEEEKRFKEKLSQCHQKEDEARASYSEFRNHNSVLDGLMKLKESGRIDGFYGRLGSLGTIPDKYDIAISTACSSLNHMVVETVEAGQQCLEYLRENNLGRAVFIILNRLPSRSMSPIETPENVPRLFDLITPKEKKFSPAFFNALQNTLVVDDLLQANRIAYGKKRWRVVTLDGQLIDKSGTMTGGGNKVLRGGMSSKLESNVSISSITKYEQERKVIEKAYQTFSSKYIQLQSKINNIAKEIPELDVKISILSLELSTYHNNILDAKKTLKEVSSLYEISPVEIKKKKELENEVASLEKENVMTRKNMVGIEQEIKQLQDRIMEIGGIRLRTQKAKVDNIQDQLNTIHDSIANADVLKIKKEKDKVRFEKAISDSKNELQVIETQVFDVKSNITKKTKLIDTLRSKIEKIQQEINDKADELLEIKSRQNEEMKVNNAARAKEIETKNKLEEYNKVLLDNEKKSKHWKDKLNGLKLQNISDTLEDNEPLELQVFSKEELKNINQEKLKSEILVLEEKTQNIKIEFGVLEEYRKREQEYKARSEDLENIVNERNSVCSYLNELKQTRLNEFMLGFNLISLKLKEMYQMITMGGNAELELVDSLDPFSEGILFSVMPPKKSWKNISNLSGGEKTLSSLALVFALHHYKPTPLYVMDEIDAALDFRNVSIVANYIKDRTKNAQFIVISLRNNMFELAARLIGIYKTENMTKTITMENIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN00</accession>
    <name>M7NN00_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_03326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875403.1">
        <property type="nucleotide sequence ID" value="XM_007877212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN00"/>
    <dbReference type="STRING" id="1069680.M7NN00"/>
    <dbReference type="GeneID" id="19897013"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03326"/>
    <dbReference type="eggNOG" id="KOG2422">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_412756_0_0_1"/>
    <dbReference type="OrthoDB" id="205993at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006994">
        <property type="entry name" value="TCF25/Rqc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684">
        <property type="entry name" value="NULP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684:SF0">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04910">
        <property type="entry name" value="Tcf25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="559" mass="64852" checksum="564E225317A7F432" modified="2013-05-29" version="1">MSFRNLKKLERLQDSSSACFIDDGLGNEIVLDYDDNDLNLLSSNNCNRFSILDTNVEIDQDTASESDNKIVKYNNGNNVHLKKCIIKKKKNKSKIINKDSYGVDDNCTFLIFHEIESINEISNKYNSLSKSITENFENKLQQRQLNLLSINLHFLDSNMEMKTLFGKKAVDDNNSRKKSKKHKASFKTSKFSKSPLMCFKESWPPLLNTGISMDIIDYIDGIGYFKFTFSKTYQDIQRQFLNAVHSFDPNNLLMLLQYNPYHVDTLLQVSEILKLEGNHQDSIDLIERALYSLGRGFHPTFNISTGYVRLPFKYSENRSMYLALYRYIHNLEKKGCWRTAFEFNKLLLSLSPLEDKDCYGALLTIDFFALMAKEYDYIIELSEWYDQEYLKRLPSFAFSYALALFHKENIDDLHINSKEKIVVAACTFPWVIKPLFLLLELNIPDGYELINPPTDLDALYMDIYLSRVKDIWNTSKHISFLCSVFLEPPLVDKNIKNLDYSIPAGVLRYVLLSGNRNFIQYLPSSITSQPIMEYDLFPPDNFTTFIDSSTFDSENNLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNJ6</accession>
    <name>M7NNJ6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SAM-dependent MTase RsmB/NOP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02879</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874916.1">
        <property type="nucleotide sequence ID" value="XM_007876725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNJ6"/>
    <dbReference type="STRING" id="1069680.M7NNJ6"/>
    <dbReference type="GeneID" id="19896566"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02879"/>
    <dbReference type="eggNOG" id="KOG2360">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_7_4_1"/>
    <dbReference type="OMA" id="MNFYQHA"/>
    <dbReference type="OrthoDB" id="435282at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009383">
        <property type="term" value="F:rRNA (cytosine-C5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049561">
        <property type="entry name" value="NSUN5_7_fdxn-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048889">
        <property type="entry name" value="NSUN5_RCM1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF4">
        <property type="entry name" value="28S RRNA (CYTOSINE-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21148">
        <property type="entry name" value="NSUN5_fdxn-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21153">
        <property type="entry name" value="NSUN5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="6">
        <location>
            <begin position="117"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="428" mass="48228" checksum="659D2B9C6986FDFF" modified="2013-05-29" version="1">MSLYERAAQILENVEAKKGSIYSLSSIYPDARRLCALIFETLKHKSLLEQIIERSGFCSCEKKVPRTLALLLIHDLLLSKNGLVRCRKSIRDAVLRHKTRLHAELVRIRLKNITPFNSIDPIVIRPRWARINTLKSNLSEVLDRFSHFSHSLIDTLLPNTYAIDIHIPNLLAFHPSTILTQHPAYLDGSLILQDKASCIPAFILSPPPKSHVIDACASPGNKTTHLAAIMKGTGHILAFERNAQRLDTLKTMLNKAGATHLVTTICLDFTMTNVYDPMFQHVTHILLDPSCSGSGRQNKEDFLQKKDTAALNERLQRLSLFQLRLVIHAMKFPSALKITYSTCSIYCIENERVAIHALKSEVAQKRGWRIAHIMPGWTTRGKIDNSSNNKALATEVANSSIRCDSNEMTGFFVCCFVRDVENENIEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNM4</accession>
    <name>M7NNM4_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_02639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874658.1">
        <property type="nucleotide sequence ID" value="XM_007876467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNM4"/>
    <dbReference type="GeneID" id="19896330"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02639"/>
    <dbReference type="HOGENOM" id="CLU_990856_0_0_1"/>
    <dbReference type="OrthoDB" id="5334849at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="281" mass="31926" checksum="8B5CB3D9A424EA4C" modified="2013-05-29" version="1">MREDKENIVVRVAQTPVARGDFSEKAGYISNLQKQDAVGFSRTSFVTPLGPRQILGGKDTNVKNMAVSVLGEKSSLLNTNRLIKNKCLYATSTKKTENKSIHKSLHEKNTIVNPFKLNESTLIENFEKVSDPEYMPPKPKSLEENIPGFSPVDLSTLQVWPLYKSYFNRLDDQGQSELEKNQQAILGESSWKLINSPVQPSDICIKKQQKSITKLYGYQKPTLSFQRKSNTNLLSNFTQKPDFINLQKQFDLSLNDFGLTQNEINPLDDSLILEDPFPFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNV9</accession>
    <name>M7NNV9_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NBP35</name>
        <name evidence="9" type="ORF">PNEG_02946</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874991.1">
        <property type="nucleotide sequence ID" value="XM_007876800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNV9"/>
    <dbReference type="STRING" id="1069680.M7NNV9"/>
    <dbReference type="GeneID" id="19896633"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02946"/>
    <dbReference type="eggNOG" id="KOG3022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024839_0_1_1"/>
    <dbReference type="OMA" id="VSGCPMR"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904564">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly scaffold complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001119">
        <property type="entry name" value="Iron-sulfur cluster carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03038">
        <property type="entry name" value="NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028601">
        <property type="entry name" value="NUBP1/Nbp35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF35">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="71"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="317" mass="34922" checksum="FD449AB0C520C643" modified="2013-05-29" version="1">MSQISQSIDKFKNVPDECPGTSSQTAGQASICKGCPNQEACLTRNPLPDPDIDCIKKRMESIQRKILILSGKGGVGKSMFTAQLAWCLSTDKKQVGILDIDLCGPSIPTIMGCNTERIHSSGSGWTPVYITDNISVMSIGFMLPSEEDAVIWRGTKKNGLIKQFLKDVEWSDLDYLLIDTPPGTSDEHMSIVQFLKENGIDGAILITTPQEVSLLDVRKEVNFCRKIGLPILGIVENMSIFICPHCHNSSHIFKANTGGAYAFSKEMDINFLGEIPLDPKMRNACDEGLNFMEEYPDSLTSQAILKIVNELSQRLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNZ8</accession>
    <name>M7NNZ8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01144</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873058.1">
        <property type="nucleotide sequence ID" value="XM_007874867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNZ8"/>
    <dbReference type="STRING" id="1069680.M7NNZ8"/>
    <dbReference type="GeneID" id="19894841"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01144"/>
    <dbReference type="eggNOG" id="KOG1617">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051314_0_2_1"/>
    <dbReference type="OMA" id="RIAMSPY"/>
    <dbReference type="OrthoDB" id="10020554at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043337">
        <property type="term" value="F:cardiolipin synthase (CMP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF60">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE (CMP-FORMING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR10428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="33296" checksum="E72C89CE8AF98668" modified="2013-05-29" version="1">MIFPKPYVARRYLFSFRYSSGLRCKLNHLYSIFPSECRLNTQRTFQTSTMLLFYSPFPLKIRNTYINYIKLKNYKKNPRNVTHENIYTIPNFLTLSRLIVAPITGYCILHEQHLYSVLFFIYASLSDVLDGWISRKWDVKSIAGTILDPMADKFFIIISTLCLTIKQQIPYYLFSVIFGKDILLGLFAIYYRWISLSPPCTFVRYFDFSIPSVEIKPTLISKINTVLQHLLIGITIIHPFIYSEILSVFLIPIQFFVFITTIWSGLSYVYTKNAILILNAQKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPG2</accession>
    <name>M7NPG2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MaoC-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873227.1">
        <property type="nucleotide sequence ID" value="XM_007875036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPG2"/>
    <dbReference type="STRING" id="1069680.M7NPG2"/>
    <dbReference type="GeneID" id="19894999"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01302"/>
    <dbReference type="eggNOG" id="ENOG502S5QU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028690_1_0_1"/>
    <dbReference type="OMA" id="NRNRMWA"/>
    <dbReference type="OrthoDB" id="3257538at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052741">
        <property type="entry name" value="Mitochondrial_HTD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152:SF1">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="38092" checksum="87BD627B5740A5BD" modified="2013-05-29" version="1">MINLYKNKRATISFIFLYRNRYYFHDKPISKLLHAPVTFISDFLSPTIGRQLNFTLSSYFKNGLDFSRFRTGNELPVGYHYLYFHRCHLEDSLAKDGGDMIYAPLRNWNRRLWAKGSLEYIKKNMEYPLRMGFPAICVERLEKVDWNGHNDDNISVWTCKEISPLDDKECARDVCLRERICIVYQSIYKMGEKTIQISKKSWIPDFSLSITPSQILLFRYSALTFNTHKIHYDYSYLKEEKYDNLLVQGSLSVIFLLELLQQNVSSDLRLKCFYYKIQSPLYANFSYKFCGKRLKELNGIQYALWVESDKLLHMKGTAEMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPI3</accession>
    <name>M7NPI3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate dehydrogenase assembly factor 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01321</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDHAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873247.1">
        <property type="nucleotide sequence ID" value="XM_007875056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPI3"/>
    <dbReference type="STRING" id="1069680.M7NPI3"/>
    <dbReference type="GeneID" id="19895018"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01321"/>
    <dbReference type="eggNOG" id="ENOG502S6UN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2498797_0_0_1"/>
    <dbReference type="OrthoDB" id="201362at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012875">
        <property type="entry name" value="SDHF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524:SF3">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07896">
        <property type="entry name" value="DUF1674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="35"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="86" mass="9831" checksum="124760D9D0996795" modified="2013-05-29" version="1">MKKSFLYRKTLLSRFFTTISLVSKNETKLSISKENFSKKKKQPDTRIPPKSDFKGYVNPETGEIGGPKTDPLIHGDYSFKGRAIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPI7</accession>
    <name>M7NPI7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_02512</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874522.1">
        <property type="nucleotide sequence ID" value="XM_007876331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPI7"/>
    <dbReference type="STRING" id="1069680.M7NPI7"/>
    <dbReference type="GeneID" id="19896204"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02512"/>
    <dbReference type="eggNOG" id="KOG1465">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_4_3_1"/>
    <dbReference type="OMA" id="SHSCAVA"/>
    <dbReference type="OrthoDB" id="269919at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000008">
        <property type="entry name" value="Translation initiation factor 2B, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051855">
        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR09172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="374" mass="41456" checksum="E1EC25247F17A906" modified="2013-05-29" version="1">MPSQDPNITIESLIFRLKRNRILTGFQVAVETALLLRQVVSTARWTNVNQLISQIQKLGSKLVEAQPKEFVSGNIVRRVLFLIREEFNNASDESELNTSADDHLAKSSIEGNLERITSSPIYSSMLNLLGKPSDYEPNVSQKFTNRINIDLRPIFIQGIQDIIDELEKTHSDIATQAMDHIHSNEIIMTYGASKTIETFLRAAAKKRKFTVILAESYPNDHASSHMSIVALTNAGIDTILIPDAAVFALMSRVNKVILGSHTVFANGGVLVSAGAKNLAAAAKHHSTPVIICAGIYKFSPVYPHNPDSLIALSSPNHVIPFDEDLMDSVDMINVCHDYIPPSMIDLYITNLGGHPPSYLARLIREHYDPEDMIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPV8</accession>
    <name>M7NPV8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription initiation factor IIA subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02241</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIA subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874226.1">
        <property type="nucleotide sequence ID" value="XM_007876035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPV8"/>
    <dbReference type="STRING" id="1069680.M7NPV8"/>
    <dbReference type="GeneID" id="19895934"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02241"/>
    <dbReference type="eggNOG" id="KOG2652">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030027_2_1_1"/>
    <dbReference type="OMA" id="NNVRQDF"/>
    <dbReference type="OrthoDB" id="6275927at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07976">
        <property type="entry name" value="TFIIA_alpha_beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004855">
        <property type="entry name" value="TFIIA_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03153">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01371">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="190"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="32173" checksum="13FB9E39D1BAB7BA" modified="2013-05-29" version="1">MSNVIVGEIYQDIISDVIQASRHDFEEYGVDSSVLTQLKQIWQTRLATTNVAQFPWTASFLTETMPVPSRRTEVPLLSNPAMSAMRAAQQIQQLAQARQARFYGGEFAQNKHLDHIPQTDGIEVETWAALKKEVFSKDSIPTTKQIDTSLNETLLQIHNTQKAFRAHEKEALGFQQSLKTQEIQGSDRSFLQTDGMDSDSINSDLDSETNSNPDDLPEHDDDGQLVLCLYEKVQRTKNKWKCVLKDGIVGMGGKDYLFMRANVRKVPIRLKTVFNLFKGEFEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ28</accession>
    <name>M7NQ28_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">WD repeat-containing protein 75 second beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00945</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872858.1">
        <property type="nucleotide sequence ID" value="XM_007874667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ28"/>
    <dbReference type="STRING" id="1069680.M7NQ28"/>
    <dbReference type="GeneID" id="19894643"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00945"/>
    <dbReference type="eggNOG" id="KOG1963">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005417_0_1_1"/>
    <dbReference type="OMA" id="TRIDGPH"/>
    <dbReference type="OrthoDB" id="4096at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057644">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053826">
        <property type="entry name" value="WDR75"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23869">
        <property type="entry name" value="Beta-prop_WDR75_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23769">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="317"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="WD repeat-containing protein 75 second beta-propeller" evidence="9">
        <location>
            <begin position="435"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR10798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="856" mass="98442" checksum="D715D052D9083DA3" modified="2013-05-29" version="1">MEINDELISYKEENKEESMELLSETDNEYHSAIDISPFTAKKEIQKKNNIIKKNVKKISYLEWKIQNVAGGSFSDITPIFTKDEKRILIALGSFVKVYDIKTGICIQTIGELDQRNNIDLPKITSMILDPSNEYRIYLSYEEGSIKLWDWTDNSILRCRQTRKKIHTIITSPLDPSSIYAVLENSSDSSNLHNFPISTKSLYKKIYEVYCYTFPSINSNSTKIIRSQRIIKFKAYVGISISHDGKILVIGNTHSIYICKKTNFENKQSSWEIRKFNTGSVINTLVIHDDHVAVGDNEGKLLIYYNILKFEEPIIRTFHWHPQPFSALNWILQGSYILTGGKESVLVFWQLKTGNKQFLPRLGSPIKKIGVSRTNSFYAILLENNSIKIINAIDLKANTEISGVQIGKDISQRLPSIVHPITKNIIFACQSLFSSTFLQSYDIVGDYQVYKTEIIRMFHLETLEKNGSIISKPKITHISLLMDGLWMATVDEWESLNEDYDLYEENTEIYLKFWRWDSTNKKWDLNTRIDSPHGLGKKVNGLHASPNKKKFSTIGSDGSLKIWKLKVKNENATVKTEIWICHKVIRYTRISDDSSKQNEIFCMTWTLDGSMIVLGCRNILLIVNEQLGTICHTVNNLYRGKIIFLQALGAFIIIITKKNILVWDILRATTKWCLDIPKIYQSLKDFCLAADHANQLFAISFNNPKEHNSKLYIFKITSPIPIFLQQHPHRIIALNHVPLNSSFSSFIFLDLSGQFFSLATDDTAFIKKNDSEPIQENEFSLSNIYGASLNRTIKSLPEDDMQFKIVSMETLSFIFDKPAYTMPSLTTLLEETMKWIGEPPLKPFSKTFYSENQKKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ38</accession>
    <name>M7NQ38_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874570.1">
        <property type="nucleotide sequence ID" value="XM_007876379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ38"/>
    <dbReference type="GeneID" id="19896249"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02557"/>
    <dbReference type="HOGENOM" id="CLU_1759588_0_0_1"/>
    <dbReference type="OrthoDB" id="5353587at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="148" mass="17642" checksum="62F3199FA5EA34AB" modified="2013-05-29" version="1">MSKRSIFIKVSVIVFVFFVFLVFFHHRKPKIKVPFVPTKEDIFDIGTPFFLEEKTPFRCFRIGECSLCPENITIPPCDKNPRYRLNIHCKYDETEEDQSKLPPLPSWVSCFPAKNLEKVHFFIVQVFFAVTSFISVSFIVWRRYIRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQP3</accession>
    <name>M7NQP3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">60S acidic ribosomal protein P1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02167</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 33 different proteins. The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and at least 46 different proteins. The acidic ribosomal P-proteins form the stalk structure of the 60S subunit. They are organized as a pentameric complex in which uL10/P0 interacts with 2 heterodimers of P1 and P2 proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09582.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613302.1">
        <property type="nucleotide sequence ID" value="XM_019757740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQP3"/>
    <dbReference type="STRING" id="1069680.M7NQP3"/>
    <dbReference type="GeneID" id="19895860"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02167"/>
    <dbReference type="eggNOG" id="KOG1762">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114656_5_0_1"/>
    <dbReference type="OMA" id="IQVENIW"/>
    <dbReference type="OrthoDB" id="2194681at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05831">
        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09582.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="11436" checksum="1E2864A37A20436D" modified="2016-03-16" version="2">MSIELAVSYATLILADDGVEITSDKLQTLVKSAGIQVENIWTSLFAKALEGKNIKELLLNINFGEPALATEGVSSLQTNETVIEEAPKEEEKEESDEDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQR4</accession>
    <name>M7NQR4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PNEG_02186</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874170.1">
        <property type="nucleotide sequence ID" value="XM_007875979.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NQR4"/>
    <dbReference type="GeneID" id="19895879"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02186"/>
    <dbReference type="eggNOG" id="KOG1035">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1936">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FEDIAWD"/>
    <dbReference type="OrthoDB" id="341578at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071232">
        <property type="term" value="P:cellular response to histidine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070314">
        <property type="term" value="P:G1 to G0 transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031571">
        <property type="term" value="P:mitotic G1 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990625">
        <property type="term" value="P:negative regulation of cytoplasmic translational initiation in response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071264">
        <property type="term" value="P:positive regulation of translational initiation in response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14012">
        <property type="entry name" value="PK_eIF2AK_GCN2_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23823">
        <property type="entry name" value="RWD_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14046">
        <property type="entry name" value="STKc_EIF2AK4_GCN2_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000050">
        <property type="entry name" value="eIF-2-alpha kinase GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000948">
        <property type="entry name" value="Related to GCN2-ser/thr protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016255">
        <property type="entry name" value="Gcn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024435">
        <property type="entry name" value="HisRS-related_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF136">
        <property type="entry name" value="EIF-2-ALPHA KINASE GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12745">
        <property type="entry name" value="HGTP_anticodon2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000660">
        <property type="entry name" value="Ser/Thr_PK_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RWD" evidence="15">
        <location>
            <begin position="14"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="230"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="549"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="142"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="749"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="555"/>
            <end position="563"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="578"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000660-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000660-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMR09602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1561" mass="181481" checksum="773B02BC19398140" modified="2013-05-29" version="1">MDLGLVECFEIQKNELEALKAIYMDDFVYIDNNTFSHTSNNPESFLKIHLHSDFNGVSFFSLDLIIYMTDTYPKTRPRVSIDNSVNLLKSQLAQIDDLILRTMNKLEGHEMIYEISSNIQDILYEWQNEYQPSINLGQERHLRILKEELKQQLTEEKMKKEQEYFKKEEEIILDEMIRKELIRRKGQLTRVNKRQQDSYGFQELSDDIIIFDKEIEIQNEQCKFIRFQAVKDLLVFRKQSFMTVKLVTPATDKNRENIFVLKDLILNSEFWNTSDGTKEIYKMEEELQAAISLRHPSIVQFHACKISLLNSGSWRLSCLQEYMPRGSLRDILENVGSVSLDIARSWAMDLLEGINEAHRRGFLHKNLHLGNILIFKSEKGRSVAKISDYGISYSLQHMNKLCSFSLNESSFSKKSNIPKIWYPPECKSETENSVFNRKSDIWMFGVIFLQMIFGINSTSKYSSLKEISDSMISGSVIDFLNFTLEINWHKRPSASDLLASPFFTSGEIARTLGLNTEILTNPFHGFVRASKYNSQSSRLHLASRYENDFEEVKWLGKGTYGKVIKVRNRLDGQYYAIKRISLNKNKNEYSRILREVMTLSRLHHQHIVRYFSAWLEDLFSGETIHDHIPRKFGRSVDSYSKGSDIIPSNVTEFVSSSRPERSFLNCFEGEISKSTSSNWSSGSIDSEISVDLKSHSSGILYIQMEYCERRTLKDILELKQVNTDEIWRLFRQILDALVHIHGQGVIHRDLKPSNIFLDENGDVKIGDFGLATECWTIIENLVSRKYSENIENDNDLTSGIGTALYIAPELLEHNTKHSYNQKVDMYSLGIILFELCYPFKTTMERIKTILNLRDSNIIFPLKFPSNKFSNQKHIITWLLQHDPKTRPTSFQLLRSELLPPKVEDEYIRESLHTLANPNTPYYLKLMEALFSQNIDKCKDYTYDIITKTLNVESPLMEWLKSCLVSIFKRHGAISNNDRSQLFPKNDIYNAGQNLATFLDCHGTLLQLPYDLILPFARQLTKCSLKYGKYYCFGKVYRNSTIDTIPWSLNEVNFDIVTKNDDNLSLYESECIKILDEIINEVPSLLKMKILININHCDILDCIFDYCGIDISYRPRASILLSQLGKSATLKQIQNQLRSESLLSGSSLEQLDKFNFQDEFEAGILRLLNIFDVSMHKRLLCSIENIRSVFLYLKYFHIEHEIFLSPLTVHNYQFYKGGLIFEALIIQNKKCDIFAVGGRYDSLINQCLPPLSSGKVSISVVGISIFIEKIFSYLSKFSFKEFPSRKYSKAISGSIRWPYNVVNCDVLVSSIGHGFLKECLEILSELWKFNIKTDLSRSNLETLDDIMDFAKKNGINWIIIVRHKSYEVNGLFKDYSVKVKNIASEHDEEITYSSLVPWLLGEIAERNRQDISENLIKFNRINDENINDMIIRKRALDVNFSKKKELSVRFLSEESSGKIKLKKKKFIINKAYEYVSELINDICSRNIVVLCVDLSDNIYELIKNTNLQENQWRKVIDATPAHQRQYVHQLWTSLKDIQSELGHQRAWLYTFRANKAFLYEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQZ5</accession>
    <name>M7NQZ5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Conserved oligomeric Golgi complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00739</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872640.1">
        <property type="nucleotide sequence ID" value="XM_007874449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQZ5"/>
    <dbReference type="STRING" id="1069680.M7NQZ5"/>
    <dbReference type="GeneID" id="19894437"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00739"/>
    <dbReference type="HOGENOM" id="CLU_681721_0_0_1"/>
    <dbReference type="OrthoDB" id="18786at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019465">
        <property type="entry name" value="Cog5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048485">
        <property type="entry name" value="COG5_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049176">
        <property type="entry name" value="COG5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228:SF3">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20649">
        <property type="entry name" value="COG5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10392">
        <property type="entry name" value="COG5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 N-terminal" evidence="5">
        <location>
            <begin position="14"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="404" mass="47670" checksum="3FD5F296FBB47040" modified="2013-05-29" version="1">MTSKKYINYERLDQPMFDVYKYANTIVKETHNPSDNMIDIDVPLRKVQYDLEEIMEQIQEKLKENHEDLINHIKFTKETSNENIGWIKKYTESLVTLFEEMDRKWTSKYESASCLLVSLKNNHVTSQLLEEVQESIILLQRLESLYQKIKSHVNEVELWKDCLRIAVIIKEWKILLQNLKDILIITKYIPFVTSVSEELESMAYDALFVKKYTSKILLVSIISTYFLLNEDALISNLKKYNSKSIEDAVEYFCKSIEINLTLKRLSITDPTKATTILLTNIEKGWSDIVNISRNIYYLNEALEESIPSFLKETFLIHKDTIISNILEKLNGEPPIQYFWKQFSSKLIPKIKDMAKQSLWLNKILYQESDFILKLIQKTLYHELHNLELQELILKDIKSSITEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NR47</accession>
    <name>M7NR47_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_00785</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872689.1">
        <property type="nucleotide sequence ID" value="XM_007874498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NR47"/>
    <dbReference type="STRING" id="1069680.M7NR47"/>
    <dbReference type="GeneID" id="19894483"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00785"/>
    <dbReference type="eggNOG" id="KOG2256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011272_0_0_1"/>
    <dbReference type="OMA" id="GCLRYYL"/>
    <dbReference type="OrthoDB" id="10266662at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030691">
        <property type="term" value="C:Noc2p-Noc3p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005343">
        <property type="entry name" value="Noc2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687">
        <property type="entry name" value="NUCLEOLAR COMPLEX 2 AND RAD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687:SF4">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03715">
        <property type="entry name" value="Noc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR11193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="602" mass="70349" checksum="DF42EBF1B8A4FF9F" modified="2013-05-29" version="1">MAKTSKSTKKFEKKTASKKNEIIEPEENELVDCFSKEVSDSLSEFISEENENDNVSLNGNDDHKAQLEALKEEDPEFYKYLKEEEAELLAFEDSDISDTKKIEDDNKKDDIDRKTLTLSVLNKWEKSLVEEKSVKVLKKVVVAVHTAIQFNEKTVFSTNSLISDSEVFNALIILAFKQVPSILYDYFQSKISMHKKEKSRDEKKEKELSFIFRTQFSNMLRLLHDLTDSNTLHLILEGAEKLIPCALTHRKFMKNLIKLLANLWSTQSHDQIRNSIYSIIEKTFSTNDKNYIEYGLKTFYTALIQQSSHTNTITLPFICSMKNFASKLFGVDQVISYQVSFKCIRQLAIYLRNAIIKHDKAKVYSWKYVHSIDFWSLVLSNYCNKIEKNTHTLVMRDLIYPLVQVTLGTIKFVSLVQFFPLKFHLIRSLIRISYYTKVYIPLAPYIFEVLESKEIKNKPNLSTAKPIDFELCIRVPQSYLKGKVYQDGLIEQIIELLQEIYSLQCKSISFPEMAMPIIIQIKRYIKQSKNSKLNKLLSIFIEKLKENSEFINSQRNSIEFLAENIDKMNAFLEDYDWNKTPLGKYVCQQRKIRQRLKKVEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRI5</accession>
    <name>M7NRI5_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873887.1">
        <property type="nucleotide sequence ID" value="XM_007875696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRI5"/>
    <dbReference type="STRING" id="1069680.M7NRI5"/>
    <dbReference type="GeneID" id="19895605"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01911"/>
    <dbReference type="HOGENOM" id="CLU_1256501_0_0_1"/>
    <dbReference type="OrthoDB" id="4094614at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038843">
        <property type="entry name" value="Sed1/Spi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35523">
        <property type="entry name" value="CELL WALL PROTEIN SED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35523:SF1">
        <property type="entry name" value="CELL WALL PROTEIN SED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082588" evidence="2">
        <location>
            <begin position="19"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="220" mass="23653" checksum="7BF26332391B3A4B" modified="2013-05-29" version="1">MRVVGVLSVLAFFSSVLAESEREPSLLPRWFGWGSGGSDSTPNVDSKELGNKLPDTKNFEDTKGGLKDIKGGVKEKDIKGNLKDKDIKGSVKENGHLESVVIKLKDGTTKTTSGKLLTTTTVVASYTTSISGPTTLNENGVKYMVVGPTVLTITDCPCTRTLTFMTSTVTKCVCTTEVTSFDVLPTDDMPFVNFATKSSIAGFGMAFIAFFLVFLTMTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRR4</accession>
    <name>M7NRR4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PNEG_01731</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">B123</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873694.1">
        <property type="nucleotide sequence ID" value="XM_007875503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRR4"/>
    <dbReference type="STRING" id="1069680.M7NRR4"/>
    <dbReference type="MEROPS" id="M41.004"/>
    <dbReference type="GeneID" id="19895425"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01731"/>
    <dbReference type="eggNOG" id="KOG0734">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_9_3_1"/>
    <dbReference type="OMA" id="MSHFEWA"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031942">
        <property type="term" value="C:i-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141164">
        <property type="term" value="P:mitochondrial protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000002">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000175">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048438">
        <property type="entry name" value="Yme1-like_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF97">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21232">
        <property type="entry name" value="Yme1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="339"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMR09972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="742" mass="83308" checksum="A97AA4215BF0AC5D" modified="2013-05-29" version="1">MANISGRIHLFLISEYLKTNFDNLIYGIGKKRLYSNRITKTFEEVFFQYNKRMIFIFIPSRSYSTDIQQFTIIKQAKMYLSINPNTRRLCTNLYSIFHQRYYRTLNQSYNCYLADLEEKANASINDPEQQYIYYKSLLNSYPEFIISRYEDTGAARNKDCDLIYAKALESTGQIEKALIVRKYINTNLQDAFSGSITQKSDNILANTQENTSSNSSSKQFSSNHPYMSIIQSFSQDTKKNPIYVITEESRQAKVFKWAKFLLSFTFVGYIFILLSTIFAESAGILRSLNKSQDIEASGDNLPDVKFSDICGVDEAKEDLQEVVDFLKNPQKFTALGGKLPKGVLLIGPPGTGKTMLAKAVAKEAGVSFFFMSGSEFDEMYVGIGAKRVRELFNIAKDRSPSIVFIDELDAIGSKRNPKDSAYIKQTLNQLLVELDGFSNKEGVIIMAATNFPESLDPALTRPGRFDKHVIVPLPDIRGRLSILKQHTKKIRMAKDIDLTILARGTPGFSGADLQNLVNQAAIKSSKLNSRYVSMKDLEWARDKILMGTERKNAFITEESKRNTAYHEGGHALVALYTPGAMKLHKATIIPRGSSLGMVMQLPDMDKYTESKKEFLAKLDVALGGRVAEELTLGKDNVTSGSLSDIQNATAIAKAMVTQYGMSDKVGPVAYDQDLSRLSSSTKALVESEIKTLLEEAQARATNILKTHKKELDRLAKALIEFETLTSEEIEKAIRGEKIDHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRT5</accession>
    <name>M7NRT5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein-sorting-associated protein 36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ESCRT-II complex subunit VPS36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01982</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the VPS36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873962.1">
        <property type="nucleotide sequence ID" value="XM_007875771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRT5"/>
    <dbReference type="STRING" id="1069680.M7NRT5"/>
    <dbReference type="GeneID" id="19895676"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01982"/>
    <dbReference type="eggNOG" id="KOG2760">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015433_3_1_1"/>
    <dbReference type="OMA" id="YAMYNKS"/>
    <dbReference type="OrthoDB" id="271448at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021648">
        <property type="entry name" value="GLUE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037855">
        <property type="entry name" value="Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031558">
        <property type="entry name" value="Vps36-NZF-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128:SF12">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16988">
        <property type="entry name" value="Vps36-NZF-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11605">
        <property type="entry name" value="Vps36_ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51495">
        <property type="entry name" value="GLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GLUE N-terminal" evidence="8">
        <location>
            <begin position="7"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="417" mass="47224" checksum="21A59D99EB6FDDB4" modified="2013-05-29" version="1">MKYWKSISVTQSNSPVLFSGEKILFIQPSTEIYDSFSKDYILKDGLIYLTTHRICYLYPSTCHIQSLGLNLSQIEELKTSTYFFKSSPKITIYYKKSEETNNLKTYNKHIEKIDSSLLIGDTWICKVCSFSNPVPESYSIDRNLPPCLACGVSIINKHLSYPKNIEVSVSESTEGESSLSCKRCTFFNHPALKQCESCGLSLVCQEKNIIYPESIVKETNKLSLEDSTNDYCKIKFKSGGERLFYERLKEAINQKEWTIKSNPIEEQNIEERKVGGISVLQYTDENIKLNNARILNQGLSSLNALMSKAKELVAFANSLRLQLQTSPNVSRNILDTLQISLQTMGLESSMTTQDLSNNLVTKEITKDDKLYYMELAKQVAEFLESGVLKKEGGIMTLVDVFALYNRARGAGKLFISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M7NS61</accession>
    <name>M7NS61_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873678.1">
        <property type="nucleotide sequence ID" value="XM_007875487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NS61"/>
    <dbReference type="GeneID" id="19895408"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01714"/>
    <dbReference type="HOGENOM" id="CLU_1939038_0_0_1"/>
    <dbReference type="OrthoDB" id="5357018at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR09956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="130" mass="14938" checksum="0240C5C12C278551" modified="2013-05-29" version="1">MRSIKDIYGHLTSKSSYTYPEPSSVLISMSSKESSVIENIERQSRIASQGQDENTGCISKPEPPIRLLFHPGAEVNTRIKDHNIGYSLDFGYERVIIKGDNDYQRWLKDYAKKDMFTDWVETTFGRLVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSH3</accession>
    <name>M7NSH3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873793.1">
        <property type="nucleotide sequence ID" value="XM_007875602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSH3"/>
    <dbReference type="STRING" id="1069680.M7NSH3"/>
    <dbReference type="GeneID" id="19895516"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01822"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028982_1_0_1"/>
    <dbReference type="OMA" id="IHNNPQT"/>
    <dbReference type="OrthoDB" id="9976382at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030905">
        <property type="term" value="C:retromer, tubulation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140318">
        <property type="term" value="F:protein transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032120">
        <property type="term" value="P:ascospore-type prospore membrane formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014461">
        <property type="entry name" value="Retromer_complex_Vps17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053055">
        <property type="entry name" value="VPS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011791">
        <property type="entry name" value="Vps17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="1">
        <location>
            <begin position="74"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Sorting nexin/Vps5-like C-terminal" evidence="2">
        <location>
            <begin position="206"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="54344" checksum="F3A742D4ECB3A2EA" modified="2013-05-29" version="1">MLRSRGSTSKKSWRTFFDAITDNKEDIEQNGSEITTEPESRYFYVIIREVERSGKVPVIRFNVDTNIEHFRSSQFTDVRRTYEEFIKLGKHLTISNPECLVPPLPPSITSAGLGLEEETKYLHIRMQKWFDLISESPILMQDKELVYFIEGHFGYSPVIRKNKHGSVLKRKAIKIQAAPPDDTPELCNLRPIIKQFYRQTSESSTKLEKVIKTLRVLSASEDELGLKFITIADMEQHSGMSNAFRKLGKIIQSISHSRLTQANIKAVIFIDTLSYISSDAFVVEEALMNRQILIKELLSAQTSSRSKVSTITRLKSSSSIKPEKVDEVLASLEETRSHEQNLNIKLTRITTNLLQEGRKWIKRTSSDIKSSLKEYTKRQIEYERRLLAILESSRPDIRNIDHTGGLSRLGREFSRLKNRNDINSSQTAQGDAWSGIQRQKNHIKKEYDSKFLKRIDDVLDARSAFETLGTKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSI1</accession>
    <name>M7NSI1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosomal protein L33-A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_00142</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872003.1">
        <property type="nucleotide sequence ID" value="XM_007873812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSI1"/>
    <dbReference type="STRING" id="1069680.M7NSI1"/>
    <dbReference type="GeneID" id="19893840"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00142"/>
    <dbReference type="eggNOG" id="KOG0887">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100745_2_0_1"/>
    <dbReference type="OMA" id="DETRVIW"/>
    <dbReference type="OrthoDB" id="1166329at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.190:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00573">
        <property type="entry name" value="Ribosomal_eL33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018266">
        <property type="entry name" value="Ribosomal_eL33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01105">
        <property type="entry name" value="RIBOSOMAL_L35AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR11708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12764" checksum="43A55BF8940C951B" modified="2013-05-29" version="1" fragment="single">MSKTHSKLYVRGRHLSYQRGKRNSNPNVSIIKIEGVNSKGETQFYLGKRVAYVYRAKKEVKGTRIRVIWGKITRPHGNSGCVRARFRHNLPPCTFGASLRIVGYIFIFIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSJ0</accession>
    <name>M7NSJ0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type proton ATPase catalytic subunit A</fullName>
            <ecNumber evidence="2">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PNEG_01499</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873439.1">
        <property type="nucleotide sequence ID" value="XM_007875248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSJ0"/>
    <dbReference type="STRING" id="1069680.M7NSJ0"/>
    <dbReference type="GeneID" id="19895195"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01499"/>
    <dbReference type="eggNOG" id="KOG1352">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008162_3_1_1"/>
    <dbReference type="OMA" id="RIVKTFW"/>
    <dbReference type="OrthoDB" id="1676488at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18111">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18119">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01134">
        <property type="entry name" value="V_A-ATPase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000008">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000052">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005725">
        <property type="entry name" value="ATPase_V1-cplx_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003220">
        <property type="entry name" value="PRK04192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01042">
        <property type="entry name" value="V-ATPase_V1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607:SF1">
        <property type="entry name" value="H(+)-TRANSPORTING TWO-SECTOR ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="27"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="ATPsynthase alpha/beta subunit barrel-sandwich" evidence="16">
        <location>
            <begin position="131"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="14">
        <location>
            <begin position="236"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="17">
        <location>
            <begin position="469"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMR10227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="616" mass="69238" checksum="720358A31EC65B91" modified="2013-05-29" version="1">MVGCIENAKKYLVKLRDAEKEGDFGFVYSVSGPIVIAEKMIGVYMYELVKVGYYELVGEVISINYDKVTIQVYEETAGIAVGDPVLRTHKPLSVELGPGLSGKIYDGVQRSLQTVQLLSKSIYIPRGIYTDALDRSVQYDFSSCNFKVGDHITGGDIFGSVYENSFLSEHKILLPPKAKGTILYIAEDGSYSIDEKIIEVEFDGKTTSYCMFHHWPVRTPRPVAEKIPADTPLFTGQRVLDSLFPCVQGGTTAIPGAFGCGKTVISQSLSKYSNSDYIVYVGCGERGNEMAEVLMDFPELSIEIDGKKESIMKRTTLVANTSNMPVAAREASIYTGITLSEYFRDQGKDVAMMADSTSRWAEALREISGRLSEMPADSGYPAYLGAKLALFYERAGKVICLGNPIRKGSISIVGAVSPPGGDFSDPVTSSTLGIVQVFWGLDKKLAQRKHFPSINWSMSYSKYLNTLQPWYENNYPGFIETRNQIKEILQKEEEMIEIIRLVGRNALSEVDKVTLDVAGLIKNDFLQQNGYSKWDCYCPIWKTFYMMRIIISYYQQALHIVDDYSIPWNKVRESTLEVFQKLSFMKFEVPDNEQEVSIRYEKLLTEISECFRKITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSN6</accession>
    <name>M7NSN6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-3' exoribonuclease 1</fullName>
            <ecNumber evidence="5">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01528</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the 5'-3' exonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="5"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873472.1">
        <property type="nucleotide sequence ID" value="XM_007875281.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NSN6"/>
    <dbReference type="GeneID" id="19895223"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01528"/>
    <dbReference type="eggNOG" id="KOG2045">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001581_1_2_1"/>
    <dbReference type="OMA" id="VASWPWF"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016494">
        <property type="entry name" value="5_3_exoribonuclease_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041385">
        <property type="entry name" value="SH3_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040992">
        <property type="entry name" value="XRN1_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047007">
        <property type="entry name" value="XRN1_D1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041106">
        <property type="entry name" value="XRN1_D2_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047008">
        <property type="entry name" value="XRN1_SH3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF7">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18129">
        <property type="entry name" value="SH3_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18332">
        <property type="entry name" value="XRN1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18334">
        <property type="entry name" value="XRN1_D2_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006743">
        <property type="entry name" value="Exonuclease_Xnr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 D1" evidence="9">
        <location>
            <begin position="702"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease Xrn1 D2/D3" evidence="10">
        <location>
            <begin position="895"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 SH3-like" evidence="8">
        <location>
            <begin position="1136"/>
            <end position="1202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR10262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1307" mass="152762" checksum="FFABDBA3ECED9B8F" modified="2013-05-29" version="1">MGIPKFFRWISERYPMCSQLITEKRVPEFDNLYLDMNGIIHNCTHMDENKREIPENEAFLAIFKYIEHIFGTIKPKKLFFLAVDGVAPRAKMNQQRSRRFRAAKEAYEFYQEKINKGEEVPKEPFDSNCITPGTIFMKKLSEQLKYFINRKVSEDANWKEIDIIFSGHEVPGEGEHKIMEYIRLSKAQPNYEPNLRHCLYGLDADLIMLGLLSHDPHFCLLREEVLFGPLKKKKQELEEQNFYLMHLCLLREYLEMEFQELKSIDDFPYNFEKILDDFILLAFFVGNDFLPNLPKLHINEGALALVFKIYKEVIPKAKGYINNSGVINLKHLALILEGLEKQEREDFKAHMENKSWVSSKKKEIGEETCLVKKKTLTMTSNQKELFLKMEEFLIQNLKKLDFSPTLSTADRYFVSKMADDFHVKCEKYTLDNKTYLSIEPYSSSEIQDMNKIESIITKELDRYKNSIILDNEESYFDKENEAFEEKWLEWKNSYYIEKLGFSINDTEKLREMAENYIQGLQWVLFYYYRGVCSWSWFYKYHYSPKVSDIKRGFDANLSFNLDSPFKPFEQLMAVLPKQSRKLIPKIFSDLMDDETSPIRDFYPENFELDMNDKKASWEAIVKIPFIEEERLLKAMKIKESLLTDEEKKRNSFGYNLKYSYDENLDYIYLPFIDIFPIIPHCHCKEEVYKLPEILGVEQLVHGLCKGVNLGNISPAGFPSLNTLPHTGHLDNQRVNVFKSESKNESMIITIQNQLDSDTIENFLEKKIGKRVFVGWPYLHEARVNAVSTEQFRYEYLPSSENSDVIISKTLNDSVAWKKSSLKLELNYKKYFGLIINTIKAIVHVSMLKGLRTTEDGALEKDYEPCNSENSEYPLQLVLNEVAVEDTRYIEKPPLDIKQEYPLGSRGFFLGKYNYGRPLEITAHKNGKIDCWIATQTREPDFGKLIYEKFLKDIHYYPSYVASKMAGLSGLVFSKILSSFYVMVDNKKVDLGLNLKYEAKKIKVLGYSRKTEKGWEYTQNAINLAREYKERFPDFIHSIQLHLFDDIPLINKLIPNDNYKEKVKDIRSWLKMINEKNNFERATLDVEQLDKLAIQTIEKELDKIAKNISLFTPKRINNVPRNAILKPSQCELRLHDQEFSLGDRVIYVHDSGKVPIATKGVIVKTGKKVIDIIFDVPFMSGTTLGGKCSAYRGLSVETHFVLNLTKQALLVSTKPLANKKYDKIKSNDRVENPGILPSQSIYPFQKNVYSKPFQTVPQIYHYNSENQSLNTSLKNNLQSHFQNIPKPHHLIHSQVQIHSTRRKIEKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSS1</accession>
    <name>M7NSS1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01569</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873522.1">
        <property type="nucleotide sequence ID" value="XM_007875331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSS1"/>
    <dbReference type="STRING" id="1069680.M7NSS1"/>
    <dbReference type="GeneID" id="19895264"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01569"/>
    <dbReference type="eggNOG" id="KOG1872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017549_2_1_1"/>
    <dbReference type="OMA" id="FKSDAEY"/>
    <dbReference type="OrthoDB" id="333239at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02657">
        <property type="entry name" value="Peptidase_C19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF1">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="7">
        <location>
            <begin position="36"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="415" mass="47653" checksum="080DE3257712980B" modified="2013-05-29" version="1">MLLGSTEAQSKMCFEQPVFLEDTSGSQLHKKLSLPSGLKNLGNTCYMNSTLQMLKSMPELESELEKISQDKTRKLDNSGTIIESLSDVFRNMNIYSDFSPLIFLGCLRIVFPQFAERDNIHGRFCQQDAEECWSQLIQNLRTHMPMNGDSPSFVNKYMVGTLINEIKCTESEDEPPIISNEDFIKLNCHIGMNTNYMIDGLKEGLKETITKRSEILNKEATFIKVSKISRLPKYLTINFVRFFWKFSIRKKVKILRKVKFPFELDICEFCEDNLKSKLIPVRDILRNINKSLEEKETRKKVKTSLDNDTYEYLEKSLNEMIKELWRLVDIKSIDEGSNVSGLYNLIGILTHSGASADSGHYQAWIRIPNSSEWCQFNDDNVTIVPRSKIETLDGGSENDTAYIALYSAMELPTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTI2</accession>
    <name>M7NTI2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01297</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873221.1">
        <property type="nucleotide sequence ID" value="XM_007875030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTI2"/>
    <dbReference type="STRING" id="1069680.M7NTI2"/>
    <dbReference type="GeneID" id="19894994"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01297"/>
    <dbReference type="eggNOG" id="KOG0858">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051898_1_2_1"/>
    <dbReference type="OMA" id="FKSQYWR"/>
    <dbReference type="OrthoDB" id="1716531at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="194" mass="22895" checksum="C230673E31A80B5C" modified="2013-05-29" version="1">MLWPLEAWYMDVPIVTRLFITGAIATSIAVQCNWVTPFQLFFSWHSVIIRKQYWRLVTTFLYFGNLSFDFLFHIFFIARYCRMLEETSFRGRSREFAYLLLYATTSLLILSPLVSLTFLASPLSFCLIYLWSRRNPSVRLSFLGLFVFNAPYLPWILLWFSFILHNTIPKGDLLGMFVGHVYYYLKDVVPTISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTM5</accession>
    <name>M7NTM5_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Histone H3-like centromeric protein cnp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_01170</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873085.1">
        <property type="nucleotide sequence ID" value="XM_007874894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTM5"/>
    <dbReference type="STRING" id="1069680.M7NTM5"/>
    <dbReference type="GeneID" id="19894867"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01170"/>
    <dbReference type="eggNOG" id="KOG1745">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078295_6_0_1"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061638">
        <property type="term" value="C:CENP-A containing chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810:SF17">
        <property type="entry name" value="HISTONE H3-LIKE CENTROMERIC PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810">
        <property type="entry name" value="HISTONE H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="9">
        <location>
            <begin position="50"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR10456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="113" mass="12365" checksum="5334460862C69A44" modified="2013-05-29" version="1">MARAKNTARKSAGRLSEGSTRAARKTLAGASGNIEPGDPIPRGKARRYRPGTVALKEIRKYQKSTDLLIRKLPFARVVRDIATDYVASFSTDFGLRWQSTAILCLQEATEGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7NU24</accession>
    <name>M7NU24_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872822.1">
        <property type="nucleotide sequence ID" value="XM_007874631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NU24"/>
    <dbReference type="STRING" id="1069680.M7NU24"/>
    <dbReference type="GeneID" id="19894609"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00911"/>
    <dbReference type="eggNOG" id="ENOG502SDYM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_801977_0_0_1"/>
    <dbReference type="OrthoDB" id="5396103at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42106:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42106">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="346" mass="39442" checksum="98DD31467BE88AD4" modified="2013-05-29" version="1">MSQNIVSNYDPSEYSFSKRKPLRCTSLHHSILLNSIEESGRISNYGLSNETNFLQGYRTNACHIQDSQDLINAMIHKETQSSSSDEERGINDIEENMVYFTDYEANLSRINMKDRLDMERMPCSFIENSNLNKKETVPDFYQKQSDNIDLFIMPYVQSDAIKRVVTRNKSLIPKPKMIQRIAESLLEESSPAESEIKNEALLSEILRKSRYISGCINSYNNIQEKELHDTADTSSMTSIHRNNLHSKDFIDLFPVKKPNTDSTVKSSPMVSPSPIKSFIQNVKTSKRKVNSDERFEPYLSFKRRAVSPSLGGSSPTLTTNSSPLSSKLSIFPMQDTNDSLMKMSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7NU32</accession>
    <name>M7NU32_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RCC1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_00925</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872837.1">
        <property type="nucleotide sequence ID" value="XM_007874646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NU32"/>
    <dbReference type="STRING" id="1069680.M7NU32"/>
    <dbReference type="GeneID" id="19894623"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00925"/>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005210_4_0_1"/>
    <dbReference type="OMA" id="RPAKLTY"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101024">
        <property type="term" value="P:mitotic nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046827">
        <property type="term" value="P:positive regulation of protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031291">
        <property type="term" value="P:Ran protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901673">
        <property type="term" value="P:regulation of mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032888">
        <property type="term" value="P:regulation of mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00625">
        <property type="entry name" value="RCC1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="93"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="4">
        <location>
            <begin position="95"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="150"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="220"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="273"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="326"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="383"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="448"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR10777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="505" mass="54826" checksum="79C29C0528677001" modified="2013-05-29" version="1">MAPPLTRNRETKQGISKIDRILKKTTKSYGDLKKISQTHSLTLDAIQRSDELGDLKLKRSFMSLRSLTSKEKVLRKPSIPFINELPVLKDERLCVFVFGTGSMSELGLGPEPTGRVVKRPRLNPLLPHDTVGIVDIAVGGMHSAAIDYKGNVYTWGVNDQGALGRDTTWKVNRTDSDSDDEQMLNPKDSVPGKVEGIPDGVKIVRMACGDSISVAITDQGQVYAWGSFRCSDGILGFSPQIKVARHPIHIKQLKNIVSVACGTDHVLALTAYGSVFSWGNGQQFQLGHRVVERTRINALVPREFGLKKIKAIGAGSYHSFAISHDGKVFSWGLNQFGQCGIESSGGEDGAVVSSPTHVQSLDHYNIVYITGGEHHSAALTLDGELLVWGRLDANQLGIPRASLPNYTVHDASNRPRFVPIPTKVPGISRVRRIYCGTHHNLAILKDDGSVWSWGFGESYQVGQGPSGNDIEVPTKIDNTAIRDKVIVAGGAGGQFSVLLGLPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M7NU51</accession>
    <name>M7NU51_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873275.1">
        <property type="nucleotide sequence ID" value="XM_007875084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NU51"/>
    <dbReference type="GeneID" id="19895043"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01346"/>
    <dbReference type="HOGENOM" id="CLU_421562_0_0_1"/>
    <dbReference type="OrthoDB" id="5329482at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082301" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="650" mass="73662" checksum="788C4C4A8322F6BD" modified="2013-05-29" version="1">MKFINFIIIFNLIFLYCQNCKGSFFLTFQEHIESNKACHDFLHNSNFKEPLIKCVRKIARESHCGGTYDVQCLCNSDHFFFSTLFVKTYASCFRSLSSDEHFSFSQFFEGLCKDPPVPDSSCVSLNKPPPPILCSDPYKGIKFGRELLACMKKFANQSLCRNVNDANCLCDSRSYWIGANECLRSEDISKLALVQEFRKSLCNSPLELPGCSGVPDVLPDCPDVFQAANLDSSLRECLTTIAKGTRCGNMDAVCLCDSKKFIDATTKQENYDICFAKLSLSVRQSYLKYKAELCSSPKQTNMCILKKPSYQQVICFDPYKDANFRDSLETCLIAAAKNSLCEQPYDSLCLCDSLSYLNAVRKCVIGLDNIERNKVGVFHEVMCKNPASLPGCRKKTELLSLCKDVFENTNFRSELKECLREIAKKSRCGGSYDPVCLCNSKYFMESTIFIDTYEKCYRLLTVEEHLAFTDFYNIMCKNPLLPPVPCIQLQVSSKKPVLCSDVYKNLEFGEKFMECMRKALKKSNCLEPYDALCLCDSKSYFDAVNRCIITTDNNEYKVFRDFSEILCKNPSLLPGCSMDTVSLTESKTTSVSTTVSSTELLKITETIKYTSTYTTIPVPGIIISHFSGSQQIKINNVFFFFIMIFIIINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NU62</accession>
    <name>M7NU62_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01355</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873285.1">
        <property type="nucleotide sequence ID" value="XM_007875094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NU62"/>
    <dbReference type="STRING" id="1069680.M7NU62"/>
    <dbReference type="GeneID" id="19895052"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01355"/>
    <dbReference type="eggNOG" id="KOG3418">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067359_0_1_1"/>
    <dbReference type="OMA" id="NQWFFTK"/>
    <dbReference type="OrthoDB" id="2365484at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06090">
        <property type="entry name" value="KOW_RPL27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.770:FF:000001">
        <property type="entry name" value="60S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001141">
        <property type="entry name" value="Ribosomal_eL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041991">
        <property type="entry name" value="Ribosomal_eL27_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038655">
        <property type="entry name" value="Ribosomal_eL27_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10497">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01777">
        <property type="entry name" value="Ribosomal_L27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="4">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR10656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="136" mass="15963" checksum="EF06B106B9BD8491" modified="2013-05-29" version="1">MVKFIKPGKVVLLLRGRYAGRKAVIVQQIDSGSKFHPFGHAIAIGIDRYPRKVTKRMGSSKVSKRSKIKPFIKIINYNHFMVTRYTFELETLKGIVTPETFREPSQREEAKKAIKRILEERYMSGKNRWFFTPIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUN1</accession>
    <name>M7NUN1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872851.1">
        <property type="nucleotide sequence ID" value="XM_007874660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUN1"/>
    <dbReference type="STRING" id="1069680.M7NUN1"/>
    <dbReference type="GeneID" id="19894637"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00939"/>
    <dbReference type="eggNOG" id="ENOG502S5FR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1343770_0_0_1"/>
    <dbReference type="OrthoDB" id="78858at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019152">
        <property type="entry name" value="DUF2046"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09755">
        <property type="entry name" value="DUF2046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="152"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="204" mass="23093" checksum="058DE5A70D325FD4" modified="2013-05-29" version="1">MSKDIPISKEKQFSVPFSVKNYSTNSGTVPVAAVAELHNALESEQEAITNNLLKRLEQLKYDKIRIESELEIESENIMNKLTRELNQLRTSQNHSSGPLSSPKQSPITFSVNTLNSPTRYVLPKRDTIPTSLVQSSLSSRLTNEIMHNSNTIETLKTENNTLKTQLKTLNAEYTNLKSERDHLKKKLDEICQTYNISIDDVLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUT2</accession>
    <name>M7NUT2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872921.1">
        <property type="nucleotide sequence ID" value="XM_007874730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUT2"/>
    <dbReference type="STRING" id="1069680.M7NUT2"/>
    <dbReference type="GeneID" id="19894705"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01007"/>
    <dbReference type="eggNOG" id="KOG1929">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_405496_0_0_1"/>
    <dbReference type="OMA" id="PKYKFAA"/>
    <dbReference type="OrthoDB" id="251770at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17740">
        <property type="entry name" value="BRCT_Rad4_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18433">
        <property type="entry name" value="BRCT_Rad4_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17723">
        <property type="entry name" value="BRCT_Rad4_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000010">
        <property type="entry name" value="DNA topoisomerase II binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561">
        <property type="entry name" value="DNA REPLICATION REGULATOR DPB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561:SF20">
        <property type="entry name" value="DNA TOPOISOMERASE 2-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="7"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="102"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="268"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="373"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="477"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="678" mass="79766" checksum="D6388F9C0F92D763" modified="2013-05-29" version="1">MSDQLNNGLKPLSGFVICCTSILSEIRVDLALKVLKLGAIYVQDLTSQVTHLIAGKLNTQKYKYVAMYRVDVKIMHIDWIFDIYKQWLKGDDISLLEYEKRYILPPFYNLLICVTNISIEHREEIEQKVIDLGGKYTRDLTRDTTHLITSNPTGKKYEFGVKWGIKIITPEWFWQSIERGACLEERLFDVHMAPNEVGKGAWFPAQENEKDEDKQISLKRRIKKIKLDLSHQVWNNIVNEGNYLENNTFKDNNDFIPIHTTPEMENSKVNGMFRGLYFYAWAFDNRKTEILQNIIKSHDGTWCKTIQDFPDEPVHIYIIVSHDLPRSKFIDIPRGFFVTEWWIERCLHNKKFIDPSEHLLCSPLPCDFPLEDMKDFSICLTGFSGIDLMHISKLIVLLGANYYESLNKKRNLLIYNINSEKSKKYIKAKDWNIRIVSQNWLWEVVKQGNVINFDEWEKKNEFENRLDGVETNNYDDHQSKILAGSVLYFYSIKETTYMNEMLILARKLGAKISKRLDNFVTHIICDEYFLNINEQTDIFIKKCKVVSSKWLLECQKHMKRLDEQDFSNIRNIEKIIKDFGYENLDIMEGKYDIKATNMNYLPDLLKDNSSEKRKKEKIKGRSTSLSIISTNTPIISSTHKNDSDVFNKNKIIQSEYVKYEDFDALYEKMQVLEKLNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVH6</accession>
    <name>M7NVH6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-ribose-5-phosphate ketol-isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoriboisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00742</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872643.1">
        <property type="nucleotide sequence ID" value="XM_007874452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVH6"/>
    <dbReference type="STRING" id="1069680.M7NVH6"/>
    <dbReference type="GeneID" id="19894440"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00742"/>
    <dbReference type="eggNOG" id="KOG3075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056590_0_0_1"/>
    <dbReference type="OMA" id="ACHVQEK"/>
    <dbReference type="OrthoDB" id="1555531at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006014">
        <property type="term" value="P:D-ribose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000014">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000018">
        <property type="entry name" value="Ribose-5-phosphate isomerase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00170">
        <property type="entry name" value="Rib_5P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020672">
        <property type="entry name" value="Ribose5P_isomerase_typA_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001924">
        <property type="entry name" value="PRK00702.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934:SF0">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75445">
        <property type="entry name" value="D-ribose-5-phosphate isomerase (RpiA), lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="249" mass="27829" checksum="A665121A50DCBA04" modified="2013-05-29" version="1">MSEYKNIWEKSFKSEIEEAKRHAAYKAVDECFSEEMKVIGIGSGTTVAYAIERIAQKDVKDIIFIPTGFQSRQLILDFGLYLGDVDAYSTVDIVFDGADEVDENLNCIKGGGACLFQEKLVASSAKKKVIIADYRKKSHILGEKWHQGVPVEVIPVACSRVMNNLIRLGSSKPRLRLSSRYKAGPMITDHGNFIIDAPFGRIKDPEILEKNIKMIIGVVEVGLFVNIADVVYFGNEDKTVISYYKGYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVP5</accession>
    <name>M7NVP5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial</fullName>
            <ecNumber evidence="11">1.14.15.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2-methoxy-6-polyprenolphenol 4-hydroxylase</fullName>
            <ecNumber evidence="11">1.14.15.46</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">COQ6</name>
        <name evidence="14" type="ORF">PNEG_00394</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-polyprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid. Also acts downstream of coq4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-polyprenyl)phenol to 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to coq6 from NADPH via a ferredoxin/ferredoxin reductase system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)phenol + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81183"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="EC" id="1.14.15.46"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81195"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="1.14.15.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.45" evidence="11"/>
    <dbReference type="EC" id="1.14.15.46" evidence="11"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872268.1">
        <property type="nucleotide sequence ID" value="XM_007874077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVP5"/>
    <dbReference type="STRING" id="1069680.M7NVP5"/>
    <dbReference type="GeneID" id="19894092"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00394"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_8_0_1"/>
    <dbReference type="OMA" id="VKQMQVW"/>
    <dbReference type="OrthoDB" id="683240at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120538">
        <property type="term" value="F:2-methoxy-6-polyprenolphenol 4-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106364">
        <property type="term" value="F:4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000021">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03193">
        <property type="entry name" value="COQ6_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010971">
        <property type="entry name" value="UbiH/COQ6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000689">
        <property type="entry name" value="UbQ_mOase_COQ6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01988">
        <property type="entry name" value="Ubi-OHases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="3 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="4 11" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="13">
        <location>
            <begin position="18"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="13">
        <location>
            <begin position="335"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR11367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="468" mass="52979" checksum="C80D8A2FF06D42F2" modified="2013-05-29" version="1">MKYLKNVKIPQYFSLNVYDIIIVGGGISGLTLASVLGSKLEDFPLRIALIEKSDLKSLKKWVPFESKYSNRISSLNLSTVLFLEDVGIWKYVKKERVQSYYGMQVWDGISSSRIDFCIGNYKENQDESKALAFMIENANLQSALLKKINEFSNFIDIFDSTKISCIKYDNCGNDVYDLSDWPVVKLLNGKTMISRLLIGADGVHSLVGKFSGIESFGWDYNAHGLVAILKLTDFSSVNEIITAWQRFLPYGPIAILPLPNKYATLVWSCPPEMAAFLKSLPKSTFLFLVNAAYRLDIADLSYILSLKSYLEIESQIKWRLGFYQKNGPVPPFAVDLQNDTRESFQLRTRHLKSYIKERIALLGDAAHTIHPLSGQGLNMGLGDVRSLSRVIFNALSIGQDIGTSQVLKQYESDRYLKNYIMLGVTDKLYKLYSTENPFIVGLRSIGLSGINKFDWIKKTLIRKVSLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVP7</accession>
    <name>M7NVP7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apurinic-apyrimidinic endonuclease 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00801</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872707.1">
        <property type="nucleotide sequence ID" value="XM_007874516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVP7"/>
    <dbReference type="STRING" id="1069680.M7NVP7"/>
    <dbReference type="GeneID" id="19894499"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00801"/>
    <dbReference type="eggNOG" id="KOG3997">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025885_1_0_1"/>
    <dbReference type="OMA" id="HPGSHLR"/>
    <dbReference type="OrthoDB" id="7663182at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000001">
        <property type="entry name" value="Probable endonuclease 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002199">
        <property type="entry name" value="PRK01060.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445:SF0">
        <property type="entry name" value="APURINIC-APYRIMIDINIC ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="ENDONUCLEASE IV ENDODEOXYRIBONUCLEASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="9">
        <location>
            <begin position="84"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="381" mass="43107" checksum="B659E612A9749995" modified="2013-05-29" version="1">MNKIPGKLELVKSATQLPEKRSFNVLEDQEVDNKDTEIKEGVSSNKSMVTFSKIQNFELFIGAHVSAAKGIENSILNSININGNAFALFLKSQRKWMSPCLKPYNIQEFRKLCNNHGFNPKKHILPHGSYLVNLASADKEKRDKSYENLIDDLKRCQQLGIGKINFHPGSCGTSSRTNGINNLVYCINKAHKDVSDVMLVIENMAGQGNTLGTNFEELSTILSKVEDKSRIGICLDTCHLFASGYDIRNKDSYNNVMNQFENKIGFQYLVGVHLNDSKTPLGSRRDLHANIGRGYIGLEAFRLIINDKRMQGIPLILETPTNDDSKVWKQEIELLRWLYGKESDDAELSAKSNELKQLAKDEHLNNLKLDKNSKKFKKIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>M7NW16</accession>
    <name>M7NW16_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PNEG_00515</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872403.1">
        <property type="nucleotide sequence ID" value="XM_007874212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NW16"/>
    <dbReference type="STRING" id="1069680.M7NW16"/>
    <dbReference type="GeneID" id="19894213"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00515"/>
    <dbReference type="eggNOG" id="KOG0243">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_33_2_1"/>
    <dbReference type="OMA" id="DWETFDQ"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000073">
        <property type="term" value="P:initial mitotic spindle pole body separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01364">
        <property type="entry name" value="KISc_BimC_Eg5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000051">
        <property type="entry name" value="Kinesin-like protein bimC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047241">
        <property type="entry name" value="KIF11-like_kin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025901">
        <property type="entry name" value="Kinesin-assoc_MT-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF12">
        <property type="entry name" value="KINESIN FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13931">
        <property type="entry name" value="Microtub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10 14" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="17">
        <location>
            <begin position="78"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="421"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="165"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMR11502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1107" mass="126694" checksum="8E36202F5BCBFD24" modified="2013-05-29" version="1">MISGRRIRPPITQRGSSLSMQSLSNSTSSIPNNEPSSPNQKPLEKKTLHVYSSEPTPIITKKKKSYENSNEINNGETNIQVVVRCRGRSKREIRENSCSIVSTEGPRGREVCVQTSPLSQMNTRTYTFDRVFGPEADQAMIFDDVVLPILREVLDGYNCTIFAYGQTGTGKTYTMTGDMSNNYGVLSDTSGIIPRTLYRLFSILETENTEYSVKCSFIELYNEELRDLLSIEDKKVKIFEDTVKKGIVISGMEDIPITNSSDGINLLQMGSHKRQVAATKCNDLSSRSHSIFTITMHIKDTTEFGEDLLRVGKLNLVDLAGSENIGRSGAENKRAREAGMINQSLLTLGRVINSLVDKSQHIPYRESKLTRLLQDSLGGKTKTCIIATISPEKINLEETISTLEYANRAKSIKNKPQVNQMMTKKTLIKEYIQDIERLKNDLNACRQKSGIYLAESSYKELTEENQSNKALVEEQQRKIDALESSLKSTREQFEQNMKLFIQTKKDLEKTSKTLEDTKNALRKTEVDLVDTKQHLDEEIVLRKAHQTTEWELDIIANELHSTLKKTIVDINSLHEKIERKTDIESSNKILWDETKSHITRFMEDLDNNITKYHLFQFQYSNKLENEITEFVTKEVEHIDDNFQFIDQQLLNFENRHAEISNEISTAKYETNNFLEEIKKLKEKIKLGIKDGFKNLNKATEKISGEVFGEMIKFQQQIHNSYSQLGHDMKSVFDDTEKHITIQTTEIQNLKSEILGLSQSIKNKIFQISDHFKKSLSQEQKKNSEEKMELLTHISSLINSFFEKQNERQTAQIDYAQSSVDDISTNIDELASTFSRKIDIWSAKEGLFVKKLMNSKEDIKNNVILSAKNSDGKGAAIQGNTQTIYSEILQLIDAQIQDVNTQIQTFDNIIAKAHSQNSVHYDAYIQNNDSVFDDIKNSYQKLKTKVNDIKKDIDVHSYFVNDLTKNQKSENDFHKDSIISQITVTHNKILSTSIKNEILTGKTPKKCNYEYPASWKLTKPHEEILKQLRKVPLSEIDTNIVSVENPKYLEFKELENNTVEEKSSSLYVEINSNSGEKLCNTNAKPSTNVESYEDEFKSKIRKRTYQMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWQ6</accession>
    <name>M7NWQ6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00151</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFA5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872012.1">
        <property type="nucleotide sequence ID" value="XM_007873821.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWQ6"/>
    <dbReference type="STRING" id="1069680.M7NWQ6"/>
    <dbReference type="GeneID" id="19893849"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00151"/>
    <dbReference type="eggNOG" id="KOG3365">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099943_0_1_1"/>
    <dbReference type="OMA" id="ENQWKWP"/>
    <dbReference type="OrthoDB" id="286811at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006806">
        <property type="entry name" value="NDUFA5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-B SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04716">
        <property type="entry name" value="ETC_C1_NDUFA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="14375" checksum="EEFD8B2706393DC1" modified="2013-05-29" version="1">MKIIHFLSQAKKLATGLTGIDGHLNPRPVLLEIYQETLKVLSSIPDHSVYRQATETLTKQRQMIVKENEITEDIENKIGCGLIEEVIFQAKDELSLAKKMLEWKSWEDLEVHPPAGQWEYFRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M7NX06</accession>
    <name>M7NX06_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872112.1">
        <property type="nucleotide sequence ID" value="XM_007873921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NX06"/>
    <dbReference type="GeneID" id="19893941"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00243"/>
    <dbReference type="HOGENOM" id="CLU_1272754_0_0_1"/>
    <dbReference type="OrthoDB" id="5386649at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="217" mass="25430" checksum="45254C6CA7B8D6CF" modified="2013-05-29" version="1">MKLKSNSDDSDSTFENTFPVSKTNFSVLNDFQQTDFLQRKLVSKEYFYNKKIVLLRFPRELTLSSIDALIFDSNKIKEIRIKGSDNIYSSYNETIMDNSYGLIFSSNGSNIYEIYQNFHFADQTTVTVMERIPEISHIAFDTPSLKRNFRSLKTKFKSNEFDDNFGDIKISELKMHSKNMTFPHVDDVNLKSIVAKKHMYGDYKNNRKKMKVKKNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NX30</accession>
    <name>M7NX30_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00150</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872011.1">
        <property type="nucleotide sequence ID" value="XM_007873820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NX30"/>
    <dbReference type="STRING" id="1069680.M7NX30"/>
    <dbReference type="GeneID" id="19893848"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00150"/>
    <dbReference type="eggNOG" id="KOG2180">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007339_0_0_1"/>
    <dbReference type="OMA" id="YKFAEAK"/>
    <dbReference type="OrthoDB" id="10261632at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.110">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 53, C-terminus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031745">
        <property type="entry name" value="Vps53_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038260">
        <property type="entry name" value="Vps53_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007234">
        <property type="entry name" value="Vps53_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16854">
        <property type="entry name" value="VPS53_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04100">
        <property type="entry name" value="Vps53_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps53 N-terminal" evidence="8">
        <location>
            <begin position="9"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Vps53 C-terminal" evidence="9">
        <location>
            <begin position="599"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="34"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="788" mass="92199" checksum="B28B2E22A6398ED9" modified="2013-05-29" version="1">MVNAIQIEDYNLLEELNNIINEPILSHEVVAPCLSHLERYKNQLNYELDKAKNELESKEKDTSFNENIKEKLKDLTEMIESMQLRAFQVEKLVTEITVDIKQLDYAKRNITYSMIVLKRLQMLTVAYEQLKMLIKTKQYEEITHLLQAIFQLTSYFKSFRSVDQIATLCNNISELKRNLFEQACLDFENIFINPMDLNKKASQLLNICNMLDILGDNARERILLWYCNSQLREYRTVFRGNDEAASLDNISRRYAWMKRMLSLYDEKHAKMFPKSWNTDERLCQNFCTNTSEDIQEVLSKSGRNIKIPILFEALQKTLEFEQYLEKRFISDYYSLTNTFNPKQKSKTITFHKSIKNAFDSYLHIFIQFHENALSNMIQSFKKLDIENEIKNNPQLMVTSSSTELFLFYQQTLTQYEKLSNVQLLFDFSYLFGKWLIIYAETILLPTMDGKHASNINICCLILNTSDYCYKTTMQLEELIKSKVSDNFREKISFDKEKEMFLNIAGISIKNLIKIIETNLSGSFKDMIKIDWSQLKNIVDQSAYVTSMTSILKNMSKKIIEKILIEKFTRIFCDKMVESFLDNFMFYITRCRPISEVGAEQMILDLYSIKMVLLKLPVITNEKNIQAHISYTKFVNKQVSKIETILKLLLTQINSSEEFVKNYFVLIGDKNTSNFLKILELKGLRKQEQSQLLEIFNIQASQYSDLIDSSPFLEPLVLSPQTGTNISLPYCFDASNINSSIFSAARENSERLYRNSIPINSESFSSSRLNEHFKGLFKRDSSLNASYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M7NX66</accession>
    <name>M7NX66_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Telomere length regulation protein conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TEL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872046.1">
        <property type="nucleotide sequence ID" value="XM_007873855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NX66"/>
    <dbReference type="STRING" id="1069680.M7NX66"/>
    <dbReference type="GeneID" id="19893881"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00183"/>
    <dbReference type="eggNOG" id="KOG4346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005799_0_0_1"/>
    <dbReference type="OMA" id="AGIMVKL"/>
    <dbReference type="OrthoDB" id="10258062at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.720">
        <property type="entry name" value="Telomere length regulation protein 2, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038528">
        <property type="entry name" value="TEL2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051970">
        <property type="entry name" value="TEL2_Regulation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019337">
        <property type="entry name" value="Telomere_length_regulation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830:SF10">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10193">
        <property type="entry name" value="Telomere_reg-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomere length regulation protein conserved" evidence="2">
        <location>
            <begin position="549"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR11751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="906" mass="104758" checksum="07964DAF1A993FEC" modified="2013-05-29" version="1">MNDIERILNTLSSQPSLQELLSVLEVIFRFQEKEEIVSCENAKIMNILTNEILPEYLPLILSKDITLSGEKMKKYLLGCLSSVSGIKAILLRIKKMTMENGNSFFFQHIAELLEILQEIFCSEGRLILVWMRCHSGINENKSIKSFSSHIWDEYVSLIAGGKLLGITSEGLLKLWKYCEIDQRPVFWIADCSKYVEHFGNEIVASINDSRFNEKMEKDFSVLTARLFSLGCTAQIIFSFFGNETITHDYLLRLDKIVKYFTFSQKTVYIHSLFSFFDKKYFQNTENFFEKLDICHELFISEIEMISIIIKDILAMDNDIIDIVDNWFLNYNSKTYIYTRRAIVNSYCSFTNGLETDDNILVRLCLKWSNKIFINYASVIEQEDLTQNFLLFSAFVPRNILEKLSHSKAYLNGLTNRLSSSSERVRFLGMIVGESVTRKLFPNDEKKWLTFNVDNTLTPESNWWRNIINVDNITNIKSLSLGSTNNDCNSSLGSGQDAIKEHEQIQPIQENDTVVAVDDEFVPYALPDSDDDDSDDDPAFTEKNKKINAPVYIRELISMLKDNTSYPKLHMALKTSPNLIRRKANFGTELSKEAVTLARIISSMNDEFNMDKFIELKQESMTALVATCPELVASYFIEQYFTGDISIQQRYMILSALALGAREISGIDSSKKKMFPSKVLVSKLHQQYVSPIDIIVKEMNMLSVKQNTSNLTKIDSLNSINPLKVRRFSKRTEIMKNKQLPKKNPLAAIAGKCFIFPMIGYWWVYTKDAYNDNFHYEPLLLSQFLKTIAIIFQASYPASLQHEILREIWEFSFFLRNQIDLIIKNALLFLILTLLEITDEKLLIQKYSYELIESRNWASVVLENASEEETRLLSSCIIFRITSLFESYKNTFIYPFSNIVDMQKYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M7P2C0</accession>
    <name>M7P2C0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2423 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875562.1">
        <property type="nucleotide sequence ID" value="XM_007877371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P2C0"/>
    <dbReference type="GeneID" id="19897160"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03473"/>
    <dbReference type="HOGENOM" id="CLU_2050623_0_0_1"/>
    <dbReference type="OrthoDB" id="5422440at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019434">
        <property type="entry name" value="DUF2423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28219">
        <property type="entry name" value="UPF0642 PROTEIN YBL028C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28219:SF1">
        <property type="entry name" value="UPF0642 PROTEIN YBL028C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10338">
        <property type="entry name" value="YBL028C_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2423" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="120" mass="14364" checksum="8DF6080EA7BFFA7D" modified="2013-05-29" version="1">MAKSIRSNKKRLYRAEKRRSIFEPIYAARVKRLSSRLKKLFSENVDDLDKMIIDQDQNNNMNRNSKDIINMNIDETQISSTKLQNEDQSQVKHAVVGLKKKKFRKIKIHKKKTVFWHMFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7P2X5</accession>
    <name>M7P2X5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">GPI transamidase component PIG-S</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_03375</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875458.1">
        <property type="nucleotide sequence ID" value="XM_007877267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P2X5"/>
    <dbReference type="STRING" id="1069680.M7P2X5"/>
    <dbReference type="GeneID" id="19897062"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03375"/>
    <dbReference type="eggNOG" id="KOG2459">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010026_3_1_1"/>
    <dbReference type="OMA" id="AEHKYAV"/>
    <dbReference type="OrthoDB" id="28748at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019540">
        <property type="entry name" value="PtdIno-glycan_biosynth_class_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072:SF13">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10510">
        <property type="entry name" value="PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR08205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="567" mass="66490" checksum="1A79A23AEC763088" modified="2013-05-29" version="1">MVNMVSFSHKQRRWIVFSYLLFVFIAIPVWWKLTEIYRAKLPLVQMDYWSKGHMCNIQFDIPIVIEVSQEFNDLKGLIKKIRQIIVSKQQENIIKLHIKEKYLNKDESYYTVKLRENNEISSVSRHIYYNRTLYIDYNLKITSELPKIISEVLLDIFSVQEKYMKFHLEKIKDQNSSSKLEDMDIKVVKYSSSFDIVFSLINGGEKNVILFWDIEKAINLYFGPLLKQLSIFSKFYVESQVQFCAELTFSPQKSKRNDVFEIPADRFSEFVNSIEWNLATTLSSHKIINFLVYVPRYDTQPLFFKDFDDHLISNNSFLVPQWGSIVIYNQEPTNVNPYLNMTSLLPIFYIFVSNFLSLLGVPSLPSYIHQEPLPILNTWRLDGLYRQRIVENMVFASTTLGSLSRLVRQISNMAVPDQVQQDVFKTIDHLRKACQNLNDFNSFSALKDASAATSLVEKAFFDPSMVSMLYFPDEHKYGVYLPLFGPLFFPLITALVQEIKAFFYYWRKKSKKKESDSAIQDNYPATQDNLSEIQDNLPAIQDKQPVQISNHSIRYRLSARFLNLFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3A5</accession>
    <name>M7P3A5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_03139</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875198.1">
        <property type="nucleotide sequence ID" value="XM_007877007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P3A5"/>
    <dbReference type="STRING" id="1069680.M7P3A5"/>
    <dbReference type="GeneID" id="19896826"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03139"/>
    <dbReference type="eggNOG" id="KOG2867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030733_0_0_1"/>
    <dbReference type="OMA" id="SWIKINA"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006970">
        <property type="term" value="P:response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016325">
        <property type="entry name" value="Phstyr_phstse_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0697">Rotamase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="351" mass="41048" checksum="0FA45E1DBCD6F4B4" modified="2013-05-29" version="1">MSLDNIVPQRRIFTNHDLELFCSSHTYEDIFGFICMLNNQVQGIPTSETFDLSQNVLYILSMLEQIHSLIDRHPPIQNNKSRFGNAAFRSFYDDMEKSAQDMHTWFSLPENTIIEVSKYFTESWGNKMRIDYGSIHELHFISWLFCLYKINILTDLDGKALIIRVFNRYILVMRRIQTVYWLEPAGSHGAWGLDDYHFLPFLFGSAQLINHKYIRPRCIHDNDILEEFSKDFIYLDYIRFINSIKTVSLRWHSPMLDDISIVKQWKNVNIGMLKMYKAEVLSKFTIMQHYLFGRLIPAAEGMTQNNHNNIAVTQCNNTWGDCCGIRIPSMIGAASIDKKDKLRVINGIFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3T1</accession>
    <name>M7P3T1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_03002</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875052.1">
        <property type="nucleotide sequence ID" value="XM_007876861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P3T1"/>
    <dbReference type="STRING" id="1069680.M7P3T1"/>
    <dbReference type="GeneID" id="19896689"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03002"/>
    <dbReference type="eggNOG" id="KOG2074">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019188_0_0_1"/>
    <dbReference type="OMA" id="FWKRYFE"/>
    <dbReference type="OrthoDB" id="360521at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13229">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027079">
        <property type="entry name" value="Tfb1/GTF2H1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013876">
        <property type="entry name" value="TFIIH_BTF_p62_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12856">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08567">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BSD" evidence="7">
        <location>
            <begin position="112"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="BSD" evidence="7">
        <location>
            <begin position="186"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="521" mass="61557" checksum="25DAD86B8C47F964" modified="2013-05-29" version="1">MDIRTFEVLYKKIKGILILKESSIEWIEFGKQMPTVSISLDSIKNLQATPITSPRAMIKIFKKDQKNEIVSYIFTFISSKAQDDCNNFKLEIQKKNSKRKYLHNIQQSVTDILTRDDFEQDIDLQQSLLKNNNELMKTFSEAVIKGNLTNEQFWSTRIHLLRTYAVEKAQKRGPYNVLTTIKPQTIDNKVKLSLNKEKIYDIFQQHPLIKHIYNENVPPLSEDDFWGRFFLSRLCKKLRGEKLNTYDSNDEILDKYLDYENDFIQSYSNDTKNISYFIDLTKNEHHITKTADFESSIIMKELENIQMMHSLNNLSTKMINCLKKNIDKKKKDNNNINNLILNDLEGIISEDNIYLYIKDQKKYFLKNSIFQEDYSKKFKRPKLYIKFENTEHQMEPIINISNINILSRDTTHDIFQQINIKSRIRHNFKTVIPLDIKNQVILCHETANEFLNQFWIKFLSNETITLQLPQIVNLLKKTNDNINTIIKSNDISINNLEIIKNYFKPTIIAIVKALQEYKNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3U6</accession>
    <name>M7P3U6_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_03016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875067.1">
        <property type="nucleotide sequence ID" value="XM_007876876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P3U6"/>
    <dbReference type="GeneID" id="19896703"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03016"/>
    <dbReference type="HOGENOM" id="CLU_1678673_0_0_1"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="157" mass="18071" checksum="EF0ACC9AC8A122E0" modified="2013-05-29" version="1">MSISHSGLFTNKTTFSKFCSLGNFGLEQSECEICFQQGFVDCKNAPSILESFTGIDSFEYRLQDILGSKRLEHKSMMQKDELEPLEVNEWLYVSPLFNHLLNVSLSFRLVSDENTSKQTLLEPIDHFNHLDVCDSSKLHNEDLFDMDHSFMEDNTCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>M7P4V5</accession>
    <name>M7P4V5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Histone-lysine N-methyltransferase, H3 lysine-4 specific</fullName>
            <ecNumber evidence="3 14">2.1.1.354</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PNEG_02650</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the COMPASS (Set1C) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="3 14"/>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874671.1">
        <property type="nucleotide sequence ID" value="XM_007876480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P4V5"/>
    <dbReference type="STRING" id="1069680.M7P4V5"/>
    <dbReference type="GeneID" id="19896341"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02650"/>
    <dbReference type="eggNOG" id="KOG1080">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004391_1_0_1"/>
    <dbReference type="OMA" id="CHMTALF"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20072">
        <property type="entry name" value="SET_SET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024657">
        <property type="entry name" value="COMPASS_Set1_N-SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017111">
        <property type="entry name" value="Set1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024636">
        <property type="entry name" value="SET_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11764">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11767">
        <property type="entry name" value="SET_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037104">
        <property type="entry name" value="Histone_H3-K4_mtfrase_Set1_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01291">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51572">
        <property type="entry name" value="SAM_MT43_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 14" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 14" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RRM" evidence="17">
        <location>
            <begin position="120"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="18">
        <location>
            <begin position="916"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="19">
        <location>
            <begin position="1039"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="233"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="531"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="667"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="239"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="539"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="586"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="701"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR037104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMR08865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1055" mass="121645" checksum="91A0617FBF0A47D8" modified="2013-05-29" version="1">MSKNDQDSQKENNIHKKGGLETPILESSKQSKISTNGIPRKKNYHIIYDPELISKEHSKGRKAIYRFDGEADPPLIIEDPRLKTLKYGKEKSRGRKTYMSILKKVEFDFDENSIGPDPPTQILVSNLSTLTTSDNISMHFKTFGDIQELEIQVNPMTGTSLGLCRIRYRKNQSNKLQGHHAAKNAVEKGNGMKVGTNIIKVEYDENGVKCKAIIEEHIKKTSLTNVSYSHKYRSSCPEESMRREEEYRNSDSIHRKLSRDHRNYDHYSPNKNDTRTNNKAYGYSQNSLGLSRIYNSNSQDFNDDFEKSEEHTHETSISMTADILKKINKSPYIFINEKCLPFSKFSINDLKKHLNKHDWTDICIDKKGFYIIFKDNQSAQKCFVTMNQTSIYQYRITMDLHRYTPTLIDQNSKFKNSFQPVDNVAEATNIIIKELSQVFMKDLKTKIIGPLLYELLDSFRFSSEIKHEKNNLAIRMSNIKLNEIESGNLNDYSTSNANSKTNEFYSKTNGLSFDGISKRFSVLPKFKKRTHDNSYGGESLRDSLRRSRNVDSRPLHHRLNDFANSHNSDSDNSDTDNQFQNMSFSDSEKEVSDVSTRDYNKSSKKVADSKKKTITIPRLRDYTSSDDDMSTSCEDNFLEQFHKRDGFDKNKKKPTSYETIYSNISDKQTKVKKNKRQNIDFTSSEEPSSEFLKEDIEDIQSSETETNESQLSEYEEKPKKKKHKKKSSNEIKKVNKSIISNEHANLDENYQISYTSTKTLLLDDDVDILLDIYGIQSIVKDEEDFMFLLEALKPVESAKIDNIALWAWGKKEIKTSNVDGYPVVTRIPKDKKYNRINKSGSARTEGYFTITDAEKSLYLPLRNKAIISTDSLTTSTTSRMNRINNRRLAVGIEMQKKISSSETDILRFNALKVRKKQLKFSKSPIHNWGLYAMEHIDMGDMVIEYVGEIVRQTVADIRERQYERQGIGSSYLFRIDDDTVVDATKKGNIARFINHSCDPSCTAKIIRVEGEKKIVIYAHRDIEKGEEITYDYKFPIEEVKIPCLCGAKVCRGTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>M7P4Y9</accession>
    <name>M7P4Y9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Mitochondrial chaperone BCS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PNEG_02692</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874716.1">
        <property type="nucleotide sequence ID" value="XM_007876525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P4Y9"/>
    <dbReference type="STRING" id="1069680.M7P4Y9"/>
    <dbReference type="GeneID" id="19896383"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02692"/>
    <dbReference type="eggNOG" id="KOG0743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010189_6_2_1"/>
    <dbReference type="OMA" id="WMTLYQR"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19510">
        <property type="entry name" value="RecA-like_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000768">
        <property type="entry name" value="Probable mitochondrial chaperone bcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="BCS1 N-terminal" evidence="15">
        <location>
            <begin position="45"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="246"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMR08910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="50710" checksum="383D64F9A397E1D5" modified="2013-05-29" version="1">MIESTVNVENDNPVIEETVKFRKKNSIVSSIFNENQFFIAGLGLMGLGTGLALFRHGIIQSMHLAKRYFTVSLEIPSKDKSYLWVLHWISSQKSMKRMHQFSVETMYKQHDNGSSSTTFSLIPGHGKHFFKYKNSWIQFYRERDGKMVDLSTGSPWETITLTTLFQDRKIFNELLHDARNLSMKMHQGKTVIYTSWGSEWRPFGQPRRRRILESVILDKDVKEQIINDIKDFLNSGDWYSQRGIPYRRGYLFYGPPGTGKTSFIQSIAGELEYNICLLNLSEKGLTDDRLNFLLSSVPTRSIILLEDVDSAFSKREQTEEHNFRNNMTFSGFLNALDGVASAEDRIIFMTTNHLDQLDSALIRPGRVDVLKYFGFATDYQIQTMFLRFYENKNKEANIFLEKIKATGVPVSTAALQGLFIYSKGDPQRAIEMIHILNEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M7P5G5</accession>
    <name>M7P5G5_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_02468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874477.1">
        <property type="nucleotide sequence ID" value="XM_007876286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P5G5"/>
    <dbReference type="GeneID" id="19896161"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02468"/>
    <dbReference type="HOGENOM" id="CLU_983931_0_0_1"/>
    <dbReference type="OrthoDB" id="5385167at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR09125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="283" mass="31673" checksum="57C23A80673FA4D0" modified="2013-05-29" version="1">MKQKATYSRKKQTITTDIKSDIRTKESPCEDLGFNMDIPNNPVLPRRTYLHKPIPARILSDKSNIVDKPVKNLVSKESVLLHKQKKKEIDNLPKKRTINRLSKPSPSKKTIPKATVPISKLRKKCPLPLDKQPPISTNKKRNLSTIACLDDSTQAKNNPHIDINDLSANILDGLSSFQQLSSDAPPVATSTPKEIKHTKEMAQPTLNISENISSDISSLLLSTSTENISEQEMLKLASLNLNTNKPIKQSRNKLKKKGMFVKYLAQPITCDSSLDDEIITKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7P5T4</accession>
    <name>M7P5T4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GPI transamidase component GPI16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874569.1">
        <property type="nucleotide sequence ID" value="XM_007876378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P5T4"/>
    <dbReference type="STRING" id="1069680.M7P5T4"/>
    <dbReference type="GeneID" id="19896248"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02556"/>
    <dbReference type="eggNOG" id="KOG2407">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021459_2_1_1"/>
    <dbReference type="OMA" id="NHGHYIG"/>
    <dbReference type="OrthoDB" id="331263at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007245">
        <property type="entry name" value="PIG-T"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959:SF11">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04113">
        <property type="entry name" value="Gpi16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="548"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="606" mass="69610" checksum="F49B1EAA5575F957" modified="2013-05-29" version="1">MLYITLHMYIYILFYIILFFPGKNGALEGNKPFFQEHLFIKPVSSSNLLASFRFNTSSDFECLPKVPYVFSGDLEGFFPGSSRLPRSLRYIMEETHTYEVHLRMTRGKWSHKGWGMLPDRGEFAGGTGIELWAYIEGDTEEIVWKRWNKLTNAFSGIFSSSIGSMDSTRIIIPILTFAKDKRHAERYELGGKGYLLHGSLPQETICTENLTPFLKLLPCKGRAGISTLLDSHRLFDAEWYSIFLDVVHFCDKDKKGLSNLVQGVDMVLNIERASRRDESPIPRPKPLNEIVCDKTRNHIKNDSCFPLDNPSNMEWSLSKLFGRPIQGSCSLDFAPTEVVTVAHPYERVISPAPNTILVEENVIFSKYMISEPFLDITMASKAYNAQFNVTSAPLFVERFLTRKNRISVVISNPHSIEFQIIYLEVFPWFMKPFIHTLNARILSSNTRYSPNFEDIYFRPSIDRKCGSYFELRMHIPCNSTIEIVWEFEKMLLRYAEYPPDPNRGVSIAPSILTVFNAGDEINKTDPIAVIRTTSLLLTLPTPDFSMPYNVIVLTSTIIAMLFGSMFNLLIRRFVSLEEAKGLKIMRLNILIFNLKTMFKKIFVYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6Q8</accession>
    <name>M7P6Q8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tethering factor for nuclear proteasome STS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02156</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Binds the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the cut8/STS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874137.1">
        <property type="nucleotide sequence ID" value="XM_007875946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P6Q8"/>
    <dbReference type="STRING" id="1069680.M7P6Q8"/>
    <dbReference type="GeneID" id="19895849"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02156"/>
    <dbReference type="eggNOG" id="ENOG502RNK4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033658_0_0_1"/>
    <dbReference type="OMA" id="DYTPHFL"/>
    <dbReference type="OrthoDB" id="10061064at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031144">
        <property type="term" value="P:proteasome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1590">
        <property type="entry name" value="Tethering factor for nuclear proteasome Cut8/Sts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013868">
        <property type="entry name" value="Cut8/Sts1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038422">
        <property type="entry name" value="Cut8/Sts1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032:SF1">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08559">
        <property type="entry name" value="Cut8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR09570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="296" mass="34017" checksum="F567672E5EBA5320" modified="2013-05-29" version="1">MEERSPVTLVLTYNNSDICFSKGSCNSLKVENNIINRICNGNSFRKSLKRKTIEDEEMSYVPLSSPAVLNSKKPRMIYHGRSFPITRLLEHLDCCTLRSIIETLVDRHPTLFSEVVGLSSLPDLFSVISLLNGMEEQVRCSFPYGGDIRGEYAYNRIRPVLQKFMDALVEYMIIFSPPYQKSRNLTLTFLDHISSMLHRLPEWNNPVHNYYKEELYDSVSNAWISVISSMSKEGFDGINGNEWIAKLIKHNETSGGRFKRVIDTARNELACFFIEKDLNVSFSNNNRLGFDFASCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7P7K0</accession>
    <name>M7P7K0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-2 complex subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_02011</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873991.1">
        <property type="nucleotide sequence ID" value="XM_007875800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P7K0"/>
    <dbReference type="STRING" id="1069680.M7P7K0"/>
    <dbReference type="GeneID" id="19895705"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02011"/>
    <dbReference type="eggNOG" id="KOG1077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003824_1_0_1"/>
    <dbReference type="OMA" id="PVLMHRY"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017104">
        <property type="entry name" value="AP2_complex_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003164">
        <property type="entry name" value="Clathrin_a-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02296">
        <property type="entry name" value="Alpha_adaptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037091">
        <property type="entry name" value="AP2_complex_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0168">Coated pit</keyword>
    <keyword evidence="3 7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="9">
        <location>
            <begin position="705"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="6"/>
            <end position="7"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="51"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR09830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="942" mass="108931" checksum="40F7231B6433B514" modified="2013-05-29" version="1">MNKPMRGLAVFISDLKNSKTRQHEEQRINQELANIRNKFKAGHLNSYQKKKYICKLLYIYILGWEIDFGHMEAVHLISSQKYSEKQIAYLAITLLLHEKHDLTCLVINSIKQDLLDSNEYYNCLALHAIANIGGKEMGDILAPDVNRLLVSPVSKNFVKKKASLTLLCLYRKNPDIIRQEWAESIISTLDDPDLGVSLSITNLLISLVQNNNRLYERCYLKAIHRLKRIVIDGEYSYDYVYYKVPAPWLQIKLLRLLQYYPPPDDKDTQELICKVLQFIITSILHELPKNVQQNNIQNAVLFEAINVAIHIDIDETLTNQTIHLLSKFISYKEINSRYLGLKALIYLAEHVNTFEPFRKYQDIIIHSLKDKDISIQRKALELLYYTCDSNNTKTIIDELIHYLESANTEIKEDIAVRIAILAEKYVTECQWYVDIMLQLINISKEHIGDDILHRFIQVIENNKELHKYSAKTVLKYLKNNPHENMIKLGGYILGEFGHLISDSPESSPIEQFISLHIKFNAYSPRTQALLMSTYIKFVNLFPEIKLDIQVVFEEYANSIDSELQQRACEYLALCHMPNNNLLRELLNKTHPFLKNQSLLISKLLKQKNEDKRLENIKEKKSSREKNKISAKSCCNYKTIDFSDLEIHKNNLIELDTSNTHSSSPSISSSKTSDQSNILSDFVSDVKYISLSDNYGLSKKYETNFNKLLCTNEGVLYEDEEIEVFIYSGYRNHLGKMELLYKNKSPLMYTSFTSSIQNSCESNLSIVSTIDIPCTLEALKQVRQVLNIEVLDIFLEPPSISISYMSTSMKSLTLKLPIVLSKFSEGVELDSGSFFHRWRQIGKSRECQKIFAIKDKEKNINFYDNVKILKGFGWEILKEIDTNNQNIVGASVLYTSQGGKYGCLLRLEPNYETKMYRITIRSTKEEIANHLESLIERELSGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M7P8D7</accession>
    <name>M7P8D7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Adenylosuccinate synthetase</fullName>
            <shortName evidence="11">AMPSase</shortName>
            <shortName evidence="11">AdSS</shortName>
            <ecNumber evidence="11 13">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_01416</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Plays an important role in the de novo pathway of purine nucleotide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11 13">
            <text>IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11 13">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 13">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="11 13"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873354.1">
        <property type="nucleotide sequence ID" value="XM_007875163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P8D7"/>
    <dbReference type="STRING" id="1069680.M7P8D7"/>
    <dbReference type="GeneID" id="19895113"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01416"/>
    <dbReference type="eggNOG" id="KOG1355">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029848_0_0_1"/>
    <dbReference type="OMA" id="FHHAKPI"/>
    <dbReference type="OrthoDB" id="10265645at2759"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019002">
        <property type="term" value="F:GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071276">
        <property type="term" value="P:cellular response to cadmium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046040">
        <property type="term" value="P:IMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.170.10:FF:000001">
        <property type="entry name" value="Adenylosuccinate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.300.10:FF:000002">
        <property type="entry name" value="Adenylosuccinate synthetase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002223">
        <property type="entry name" value="PRK01117.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846:SF0">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 11 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11 13" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="20"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="21"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="46"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="48"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="303"/>
            <end position="309"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="335"/>
            <end position="337"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="417"/>
            <end position="419"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR10140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="428" mass="48158" checksum="019344BDE6A94C8D" modified="2013-05-29" version="1">MATGQKVQDGVTVILGVQWGDEGKGKLVDILSREADLCARCQGGNNAGHTIVIGDQTYDFHILPSGMTSPNCLNLIGSGVVIHIPSFFAELEAIEKKGICTQNRIFVSDRAHLVLDYHQVIDELKELELGEYSIGTTKKGIGPAYSHKAERNGIRVHHLYDFSEFERLFRENFESCRRRYGQFEFDVEKEINKYREYAEKLRCYVVDAVYFIHSIMTTQKRILVEGANALMLDIDYGTYPYVTSSNTSIGGVCTGLGLPPKKIKNVIGVMKAYTTRVGSGPFPTELFDNIGEHLQRTGSEWGVTTGRKRRCGWLDLVLVRYSNWINGYSSLMITKLDVLDTLKEIKIGIAYKVNNKEIPYISADLKTFKNLVVEYKTLPGWLTKTSGCTSFDQLPIQAQTYVKFIEDFIGVKILYIGVGPSRNDIILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M7P914</accession>
    <name>M7P914_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Pre-mRNA-processing factor 19</fullName>
            <ecNumber evidence="5 18">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PNEG_01576</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 18">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the WD repeat PRP19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 18"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873530.1">
        <property type="nucleotide sequence ID" value="XM_007875339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P914"/>
    <dbReference type="STRING" id="1069680.M7P914"/>
    <dbReference type="GeneID" id="19895271"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01576"/>
    <dbReference type="eggNOG" id="KOG0289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023894_0_1_1"/>
    <dbReference type="OMA" id="SLDQHWA"/>
    <dbReference type="OrthoDB" id="687049at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16656">
        <property type="entry name" value="RING-Ubox_PRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000027">
        <property type="entry name" value="Pre-mRNA-processing factor 19, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038959">
        <property type="entry name" value="Prp19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013915">
        <property type="entry name" value="Prp19_cc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055340">
        <property type="entry name" value="RING-Ubox_PRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08606">
        <property type="entry name" value="Prp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 18" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15 18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 18" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="14 18" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="16 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 18" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="9 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="13 18" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 17" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="U-box" evidence="19">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="279"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="362"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU367101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMR10320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="478" mass="53518" checksum="9AB051ED6A42C54F" modified="2013-05-29" version="1">MFCALSGESIDIGVVSKKSGNVYEKRLIEAYIQENEKDPVTGEPLTLDDLVELKTSKTIRGRPPQATSIPSLLAIFQNEWDSLALETYNLKQQLNQARQELSTALYQHDAACRVIARLLKERDEAREALKKIKISLEFPGTSITNNEQMDVDAQALPEHVIQKIDETQKTLSSNRRKRKIPADWTTVEQIQQFKLSKSISPFKSKITSIAITDLGNMILVTCKNTLKIYYVTDEKPAYSLKSPGGEITCGLWIGELPAIAKSDGTIHIYTSLDDNDKKISTHESKVISLALHPSNDLLASATIDGEWALHDLQSDQTIAKYRENTEFTCAKFHPDGYLFACGTIDGLIKIYNVKTGKNVANFDSHKGSITSLCFSENGYWLSVSSAQDSRVHIWDLRNNTQTQFLQATDSILSLNWDYTGQYLAIGSPKTITLWSYSKSTKSWTKLQDIQNPVSHLLWGSRAATLFVANDTNLTTFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7P9D2</accession>
    <name>M7P9D2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP synthase subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01184</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the eukaryotic ATPase B chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873099.1">
        <property type="nucleotide sequence ID" value="XM_007874908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P9D2"/>
    <dbReference type="STRING" id="1069680.M7P9D2"/>
    <dbReference type="GeneID" id="19894881"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01184"/>
    <dbReference type="eggNOG" id="KOG3976">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077208_0_0_1"/>
    <dbReference type="OMA" id="YTEWADG"/>
    <dbReference type="OrthoDB" id="67388at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008688">
        <property type="entry name" value="ATP_synth_Bsub_B/MI25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013837">
        <property type="entry name" value="ATP_synth_F0_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733:SF3">
        <property type="entry name" value="ATP SYNTHASE F(0) COMPLEX SUBUNIT B1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE B CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05405">
        <property type="entry name" value="Mt_ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161060">
        <property type="entry name" value="ATP synthase B chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0138">CF(0)</keyword>
    <keyword evidence="3 8" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="236" mass="26866" checksum="898B72EA956D8818" modified="2013-05-29" version="1">MLFPAARKGVRGILTSLRPISLSVFYNQKWDNCNFSTKIDPKLKAATIIDMLPKLSFLSKTGIIATGTVLSIAAISNELYVVNEETIILGSFFSIIWFLINSGKQNYINWMDGHINHVRSLLNNSRQQHTIAINERIVAIKPLKDIVDVTKNLFEVSKETVHMEAKAFELSQIIAVQQQAKAVLDSWVRYESALRQREQAYLANTVISKVEKELRQPKIQQQILDQSITKIENLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M7PA73</accession>
    <name>M7PA73_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872805.1">
        <property type="nucleotide sequence ID" value="XM_007874614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PA73"/>
    <dbReference type="GeneID" id="19894592"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00894"/>
    <dbReference type="HOGENOM" id="CLU_455011_0_0_1"/>
    <dbReference type="OrthoDB" id="10662558at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="600" mass="68781" checksum="506676E07C388F6A" modified="2013-05-29" version="1">MIEEKFINDIDIEKSGTDKNIDGNIDGNINGDTESVKAIYIKENFTQKRQKSCLSTCTIQRRSGKIWNHDNEQRNLLGRSSSDIGVKYRSNTFTTLSASSDTDSLLTIEMQETLESEKILDSSDKLSEGSDNLLNEAPDSSNSLVSDSSNSLVSESLNTLKRSKRYRHQPIRHIFKEKVYKEFPWESLQEKDNLLSKEEFHKNENFMKNNFEKKKAIKFKSVLSIIEEISKSTSELLNTGLQYVEMPNSLYESSITESEKSIDIPFPSPTITLQQGENIYGNEEIEEQPNRTSLFRRSIFGGYIPENNFQSIKLALKEIVQDNKKLREKKGLSDKHMQYSSVENGSTNNLINSNISVLAQNDLKSNKLSKVNKEHQNNHTFMNRFSESRLSLQETSNLNNSFEFLLENYKNYKLTTIKGSPDSTFALNIQKDVDGKSISKEKNIKNISFEAKRIANNENIRPNDDSLFNLKNSNKISRNYNYNDSSILDFNQVNKQTNPEDFSSIDSCNNTYPIHTEQFNENEGSDLNSDKLSSWLLSVKNKYQNIDLEKICDICNSTDLDSKHSSQMENNQIINIFSFSKLGNKSSFIVKKTFNSFKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAI3</accession>
    <name>M7PAI3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KIN17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872915.1">
        <property type="nucleotide sequence ID" value="XM_007874724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PAI3"/>
    <dbReference type="STRING" id="1069680.M7PAI3"/>
    <dbReference type="GeneID" id="19894699"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01001"/>
    <dbReference type="eggNOG" id="KOG2837">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030065_0_0_1"/>
    <dbReference type="OMA" id="NHEDERD"/>
    <dbReference type="OrthoDB" id="10266249at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2030:FF:000001">
        <property type="entry name" value="DNA/RNA-binding protein KIN17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2030">
        <property type="entry name" value="DNA/RNA-binding protein Kin17, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056767">
        <property type="entry name" value="C2H2-Znf_KIN17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019447">
        <property type="entry name" value="DNA/RNA-bd_Kin17_WH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037321">
        <property type="entry name" value="KIN17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038254">
        <property type="entry name" value="KIN17_WH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805:SF0">
        <property type="entry name" value="DNA_RNA-BINDING PROTEIN KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805">
        <property type="entry name" value="KIN17 KIN, ANTIGENIC DETERMINANT OF RECA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25095">
        <property type="entry name" value="C2H2-zf_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10357">
        <property type="entry name" value="WH_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01253">
        <property type="entry name" value="Kin17_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="245"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="157"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="300" mass="35722" checksum="89B5BA42F3A7399F" modified="2013-05-29" version="1">MGGRAEKGTPKWLANRMKSKGLQRLRWYCQVCEKQMRDENGFKCHTQSEAHVRQMLLIGENPNRHIHNYSVEFKNNFIQLLRTSHGEKRVHANHFYQEYIADKGHLRMNATRWVTLTEFVKYLGYEGICRVDETDKGLYISWIDNSPEALRRQQSIIKRDRQDKGDEERELKMINEQVERAKKMVKDDEQDHENVIKELKRNENKISISLSKPSVHQENALSILQEDEKSRSNKISSLKKQENVFKTLARSTPPKQIQNKEKKPLTTAEKIILEEMEERKRKEMQRDNHFDSKRRRVHLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCG2</accession>
    <name>M7PCG2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Golgi apparatus membrane protein TVP18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_03334</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875412.1">
        <property type="nucleotide sequence ID" value="XM_007877221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCG2"/>
    <dbReference type="STRING" id="1069680.M7PCG2"/>
    <dbReference type="GeneID" id="19897021"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03334"/>
    <dbReference type="eggNOG" id="ENOG502S3AC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118698_0_0_1"/>
    <dbReference type="OMA" id="IYAQWLG"/>
    <dbReference type="OrthoDB" id="5591789at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019365">
        <property type="entry name" value="TVP18/Ca-channel_flower"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314:SF2">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10233">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01077">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16361" checksum="187E1E615863CE9D" modified="2013-05-29" version="1">MGFSDEIKSRNFSIYAQWFGILSMILCLILGFSNLFHIGVIVVFGILSMIMGIILSFVEIPHLLRICPTSQKFDSFVEYFNQNWPRAGLYAIFSITLFLSGIVKWTSLIVPALFMAITCLCYTTAALQGKEFISSSVFGGTGVSQTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCK2</accession>
    <name>M7PCK2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="15">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PNEG_00073</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="15">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="15"/>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871930.1">
        <property type="nucleotide sequence ID" value="XM_007873739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCK2"/>
    <dbReference type="STRING" id="1069680.M7PCK2"/>
    <dbReference type="GeneID" id="19893771"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00073"/>
    <dbReference type="eggNOG" id="KOG0342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_26_5_1"/>
    <dbReference type="OMA" id="LMEFHSQ"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990417">
        <property type="term" value="P:snoRNA release from pre-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17942">
        <property type="entry name" value="DEADc_DDX18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000379">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000460">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044773">
        <property type="entry name" value="DDX18/Has1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14 20" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="19">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="97"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="287"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="522"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="543"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMR11635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="559" mass="62829" checksum="EB377BCAAD0DBA19" modified="2013-05-29" version="1">MTLNLQEKKSTENDLIDKDTLKKILKTEKKEKKSNIISETEANTNSHKDSSLISSMSATSTKDSPVLFSDLSLSKPTEKALQNMGFSKMTEVQARTIPILMTGKDVLGAAKTGSGKTLAFLIPAIEILYSLKFKPRNGTGIIIISPTRELALQIFGVAKELLEYHSQTFGVIIGGANRRAEAEKLEKGVNLLIATPGRLLDHLQNTKGFIYRNLKALIIDEADRILEIGFEDEMRQIIKILPNENRQSMLFSATQTTKVEDLARISLRPGPLYINVDSDKKSSTVDGLEQGYVVCDSDKRFLLLFTFLKRNLKKKIIVFFSSCNSVKYHSELLNYIDIPVLDLHGKQKQQKRTNTFFEFSNAKQGILICTDVAARGLDIPAVDWIVQYDPPDDPRDYIHRVGRTARGAEAKGKSLMFLVPSELGFLRYLKAAKVSLNEYEFSKLANIQFQLEKLISKNYYLNKSAKDGYRSYLQAYASYALKSIFDVNNLDLAKVAKSFGFAIPPSVNINIGSGSKSSRKYSKNLKRSYHSSSKNEHFKKQKTSLIHKSTENGKNTWSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCM8</accession>
    <name>M7PCM8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FMR1-interacting protein 1 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871960.1">
        <property type="nucleotide sequence ID" value="XM_007873769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCM8"/>
    <dbReference type="STRING" id="1069680.M7PCM8"/>
    <dbReference type="GeneID" id="19893801"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00103"/>
    <dbReference type="HOGENOM" id="CLU_943719_0_0_1"/>
    <dbReference type="OMA" id="NICETND"/>
    <dbReference type="OrthoDB" id="273070at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019496">
        <property type="entry name" value="NUFIP1_cons_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10453">
        <property type="entry name" value="NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMR1-interacting protein 1 conserved" evidence="1">
        <location>
            <begin position="120"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="295" mass="35094" checksum="9F2C04568134E99E" modified="2013-05-29" version="1">MNQQYIYDPPPSPPPKATMFLSPLKTHSPLQLSKKKFHRVEKIYKNNYNSGKNNFKNFLSKPEKSLKNIKNKSDRPDKLEKYSKCTYSTLLDDGTISYKTVFYNKDGYAMSSTANICETNDNESIENIPKNEKTEIQEDINAWIEERKKKWPTDKNIEKKKEEKLKELNRIKDSFEEKIKLDFLENNDHFKPANDNCIKSNEVKKIETPELLFENINSPLSYFLKEKSDDKSNYGFKHDNISKKKHEKRFTKSNRNCIWRVRKSLYTKLVEKEELQENMIILQVIKHLIEFYNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCN2</accession>
    <name>M7PCN2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cystathionine gamma-lyase</fullName>
            <ecNumber evidence="4">4.4.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Gamma-cystathionase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00108</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871965.1">
        <property type="nucleotide sequence ID" value="XM_007873774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCN2"/>
    <dbReference type="STRING" id="1069680.M7PCN2"/>
    <dbReference type="GeneID" id="19893806"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00108"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_2_3_1"/>
    <dbReference type="OMA" id="YKQDGVG"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004123">
        <property type="term" value="F:cystathionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000008">
        <property type="entry name" value="Cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000009">
        <property type="entry name" value="Cystathionine gamma-synthase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF15">
        <property type="entry name" value="CYSTATHIONINE GAMMA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="5 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="393" mass="43230" checksum="5294A0ACB1161732" modified="2013-05-29" version="1">MKNNKLGFGTLAIHSGSGTDPQTGAVISPIYLSTTFAQLSPGNPVSKYEYSRSGNPTRENFEEAIKTLENAKYALAFSSGCAALMTIFHILSPGSHAISAMDVYGGTHRYLTKIASTYGIEVTFADLKDEKSLNLYIRPETKLLWIETPSNPTLSVIDIFFISKLAHQHNIIVVIDNTFLSPYLCNPLDHGADIVLHSATKYINGHSDVILGVIALNSDVLYTKFKFLQNAIGAVPSPFDCWLAQRGLKTLHLRYKQCCINALAIAKALEKHELVIQVFYPGLESYPQRKIVEKQHRNGLGGGMVSFRIKGGSTAAEKFCQSTKLFCLAESLGAIESLCEIPALMTHSGISKEEREKIGIYDDLIRLSVGCEEEEDLVNDISQALEKSSIYNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCR1</accession>
    <name>M7PCR1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PAN2-PAN3 deadenylation complex catalytic subunit PAN2</fullName>
            <ecNumber evidence="10">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Poly(A)-nuclease deadenylation complex subunit 2</fullName>
            <shortName evidence="10">PAN deadenylation complex subunit 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PAN2</name>
        <name evidence="12" type="ORF">PNEG_03411</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 2 metal cations per subunit in the catalytic exonuclease domain.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Positively regulated by the regulatory subunit PAN3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase C19 family. PAN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="10"/>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875497.1">
        <property type="nucleotide sequence ID" value="XM_007877306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCR1"/>
    <dbReference type="STRING" id="1069680.M7PCR1"/>
    <dbReference type="GeneID" id="19897098"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03411"/>
    <dbReference type="eggNOG" id="KOG1275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002369_1_0_1"/>
    <dbReference type="OMA" id="GCISCEM"/>
    <dbReference type="OrthoDB" id="16516at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06143">
        <property type="entry name" value="PAN2_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000028">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex catalytic subunit PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03182">
        <property type="entry name" value="PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030843">
        <property type="entry name" value="PAN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050785">
        <property type="entry name" value="PAN2-PAN3_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048841">
        <property type="entry name" value="PAN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028881">
        <property type="entry name" value="PAN2_UCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728">
        <property type="entry name" value="DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728:SF0">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20770">
        <property type="entry name" value="PAN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13423">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="USP" evidence="11">
        <location>
            <begin position="393"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="786"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="788"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="895"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="948"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR08244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="996" mass="114011" checksum="E03792A2F07EC125" modified="2013-05-29" version="1">MNRRGLFKWTLDNLNMDLQCMTFISRTSSNILVGGLQSSMLTINIERGSVVDKLHCKEDTVVMRHGRYICCGSSKGGLSLLDPSDYKEVHSIQAHSGTFSDLDIQGNLILTCGFSRRDAHYVIDPLVKVFDIRTLRPLVPVAFPAGPAYIKMHPKMSTTAFIISQSGLFHIVDTVNTVNVQLRHASSNTYFTSVCVSQSGDALILCDAEGILQLWSQKPAPNFSEFSIPLEWPNIPTNIPDIQIHDDTPLNVIGMPYYREELFSSWPAHLIYDVGKIPCVLNPDTISNLKTLEFVGYSMYTENMKRNQTRYYARNKDAGTRGLIAPKFHSEKAKELTLGNIKKDSAPLHFEDENDDLNEPSVIPKYYKLLEIKYSKFGVEDFDFGYYNNTPFSGLEIHIENSYCNSLVQLYYFIPSIRQLAIAHSISSCIKEDCLLCEMGFLFKMLFDANGQNCQATNFLHVLSTSSQAMSLGLIIDESMEKKISFSPIIQGLNRFLLEKLNEESLDKCSSDEHNTNNISPLAETNGIFSKIISFCTCGVNSIRNSIIFSIDFIYPKITSEKNFSLTSFSSILAASINREKQNKAWCSNCHQFRFLTTRRTISSFPCYLNINAMAYTQEHWKYWSSKNWLPTKIALNHHLGKVICFQGKDINKKTNNEFYIYELKGLVVEICFKNESHLVSFIHVTDENIKLKYKTSWFLFNDFLVMSVSEDQVLNFSKAWKVPAILIYEKVDYSESLIKMKLPSLDISILYRDYSISLNRNIQTIRHQILEGTEKIDHNTVIGLDAEFVSMQKEEIDVRSDGTRFIVRPSKLSLARVSAVRGNGKLENVPFIDDYIAVNEPIVDYLTEFSGIKHGDLDPMISKYTLVPLKIAYKKLRLLVTLGCKFVGHGLQKDFRIINIHVPKDQVIDTVNLFYLESRQRKLSLRFLAWYLLQDYIQQDSHDSIEDARTALLLYKKYENFKKEGIFEEKLKEIYDLGKKYGYKPPVANDKRELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCT5</accession>
    <name>M7PCT5_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_03421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875507.1">
        <property type="nucleotide sequence ID" value="XM_007877316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCT5"/>
    <dbReference type="GeneID" id="19897108"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03421"/>
    <dbReference type="HOGENOM" id="CLU_1409335_0_0_1"/>
    <dbReference type="OrthoDB" id="10349760at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="193" mass="22880" checksum="6AD6471302C75D74" modified="2013-05-29" version="1">MLSQSFFHLSEHKQLVLSLFKRLLFYAKRLPVDSQEICIHLIKDYFSTMKTSTNLKKNIDGLKYAYKAEQILKEAVVLKNSVLLKKLQMYLSEYKSEQVKKKLSLIKLSKRKDYSRLCMILTKRIRSFQNLQDRLTKLQDILFHAKHEQQFYKRLGISEQGWTSELETHIGVINIQLSLQTIKKMVLKAQLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7PF33</accession>
    <name>M7PF33_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription initiation protein SPT3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SPT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874426.1">
        <property type="nucleotide sequence ID" value="XM_007876235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PF33"/>
    <dbReference type="STRING" id="1069680.M7PF33"/>
    <dbReference type="GeneID" id="19896113"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02420"/>
    <dbReference type="eggNOG" id="KOG3902">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038706_2_0_1"/>
    <dbReference type="OMA" id="QFMFNEQ"/>
    <dbReference type="OrthoDB" id="66982at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22926">
        <property type="entry name" value="HFD_SPT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000023">
        <property type="entry name" value="transcription initiation protein SPT3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF16">
        <property type="entry name" value="TRANSCRIPTION INITIATION PROTEIN SPT3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="35127" checksum="769F83BC41830E93" modified="2013-05-29" version="1">MSSEKKYKIEIQQMMFVLGEVLDSLPETTALVEDIVRGQVIEMITQATQHAMKRGSRTISVEDLIFLIRHDKPKVNRLKTYLSWKDVRKNAKEQDGVESSEILDDSDTKMRVRKSRIDLPWDIYSMFNEPIPFNLDEEDDYDSDEQESNLDTLLRLRFADLRTRTMTKDEYVHYSECRQASFTYRKSKRFREWSGMNQLIDSRPNDDIIDILGFLTFEIVSTITEESLRVKAQMDSLEESSALKERRGGKYLFDDPEEGRTPLQIKHVEEGFRRLQTPRPKHVAMRGFDGGLVKSRVNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7PFD8</accession>
    <name>M7PFD8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Checkpoint protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02514</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the HUS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874524.1">
        <property type="nucleotide sequence ID" value="XM_007876333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PFD8"/>
    <dbReference type="STRING" id="1069680.M7PFD8"/>
    <dbReference type="GeneID" id="19896206"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02514"/>
    <dbReference type="eggNOG" id="KOG3999">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035754_0_0_1"/>
    <dbReference type="OMA" id="VCWMRLE"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044778">
        <property type="term" value="P:meiotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016580">
        <property type="entry name" value="HUS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007150">
        <property type="entry name" value="HUS1/Mec3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900:SF0">
        <property type="entry name" value="CHECKPOINT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900">
        <property type="entry name" value="MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04005">
        <property type="entry name" value="Hus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011312">
        <property type="entry name" value="Cell_cycle_HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="287" mass="32544" checksum="3CF7039F5B3C3AE7" modified="2013-05-29" version="1">MRFKTGISNISTFIRLVQSLERIGRICWLKLTPETVHFIVVPDHTGTQVWAYEIINNSMFLIVTSIFRDYHIQSNTDNIINLEIPVDNLHKALKSSVNASEIILRLTKQDHFPMLSCSISLLGKSGSMSAVTHNIHVRVLSPLVQLSEPVVPEPDCHIILPPLSQLRYISERFRAISNKIILKANMSGEFQIGVVSDSCKIETKFKDLINPELDPNTVKDISKHPSQIRDKKSFVTMKVDVKDWLNLLQVHIVAKRVIACFCEGHALVLYVYIMEPEDENSAVLVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7PFI9</accession>
    <name>M7PFI9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA(Ile)-lysidine synthetase</fullName>
            <ecNumber evidence="1">6.3.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(34) in tRNA(Ile2) + L-lysine + ATP = lysidine(34) in tRNA(Ile2) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="1"/>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874573.1">
        <property type="nucleotide sequence ID" value="XM_007876382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PFI9"/>
    <dbReference type="STRING" id="1069680.M7PFI9"/>
    <dbReference type="GeneID" id="19896252"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02560"/>
    <dbReference type="eggNOG" id="ENOG502QQNE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015599_1_0_1"/>
    <dbReference type="OMA" id="ARIPECH"/>
    <dbReference type="OrthoDB" id="434144at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032267">
        <property type="term" value="F:tRNA(Ile)-lysidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="TRNA(ILE)-LYSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033:SF1">
        <property type="entry name" value="TRNA(ILE)-LYSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="7">
        <location>
            <begin position="22"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="470" mass="54689" checksum="57EA6F6DF2A6CF43" modified="2013-05-29" version="1">MKLYIDLLLKPFQHLINYRWGFAVSGGCDSMALCLLFQNMANRIYTFTVDHQLRPKSREEAEEVHKKMTQMGFQHKILTIAWPKDKYFKGSLEALLRDQRYTLLTQECLNNDIGVLFLGHHLNDQIETVLMRLIRKSGSSGLAGMQKISSNPMIGRVKDSEKILICRPFLDIPKIVLKSACEKYGLTWFEDPTNALMNISKRNAIRALFQKPEQLPKALRPYNILHLANIMAVKRMEISEKVKQLLTKTHITFSEMTGSLDVICDMDIYDENIATLSKWLGHLVFIVSPLSRQRISVVRRIVIDLFEEKLVKTKQYTVGGVLIHTTRHFQALFMQLSRQPYEKSMKERFAVFLQSSSFSNPQNTWILWDGRWWIRILSKNNEIMQFKVRPLMESDMKLLYSMIYAADSCNRKMMLDSLKTIKGYARFTVPLVETKIRIIGLPTLGIIFDYTFIIETKFKIDISTYLNCII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7PFP8</accession>
    <name>M7PFP8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02598</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874613.1">
        <property type="nucleotide sequence ID" value="XM_007876422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PFP8"/>
    <dbReference type="STRING" id="1069680.M7PFP8"/>
    <dbReference type="GeneID" id="19896290"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02598"/>
    <dbReference type="eggNOG" id="KOG3155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094365_1_0_1"/>
    <dbReference type="OMA" id="TPSKWWL"/>
    <dbReference type="OrthoDB" id="200404at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051654">
        <property type="term" value="P:establishment of mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1760.10">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007204">
        <property type="entry name" value="ARPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036753">
        <property type="entry name" value="ARPC3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12391">
        <property type="entry name" value="ARP2/3 COMPLEX 21 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04062">
        <property type="entry name" value="P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016315">
        <property type="entry name" value="ARP2/3_P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69060">
        <property type="entry name" value="Arp2/3 complex 21 kDa subunit ARPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="177" mass="20340" checksum="CEAC4C2D7972F7EB" modified="2013-05-29" version="1">MPAYHSSFINNTEFQIAGFAILPLKTKFRGPSQIVNDLSVQDIVDECIELFRANCFFKNFEIKGSADRTLIYGILFISDCLNKLSRANCTKNDSIKLLNTFALENFTIPGDAGFPFNSLYPAPSNQSDLDFLRQYIAQFRQELALRLINHVYANSDNKPNKWWLCFSKRKFMNKTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7PGD8</accession>
    <name>M7PGD8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874087.1">
        <property type="nucleotide sequence ID" value="XM_007875896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PGD8"/>
    <dbReference type="STRING" id="1069680.M7PGD8"/>
    <dbReference type="GeneID" id="19895799"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02105"/>
    <dbReference type="eggNOG" id="KOG4781">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052827_2_1_1"/>
    <dbReference type="OMA" id="GRKCIIT"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF7">
        <property type="entry name" value="THIOESTERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G10800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="120"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="228" mass="26103" checksum="4CE8D5036F7F3F98" modified="2013-05-29" version="1">MLGILSISSFSIFFGYKLNDLLRKNFYLSNERIIETNIDYEIENYIESHSLTQLLRSKPYISETRPYLDLSLKFKSFNFTAGLLFGKGRISVAPYCFYDEKEKEITIIFHLGTQICGYENIIHGGLLATLIDEGFARCSYLMFPNKPRFTANLNINYRAPAKANNYYVLKAKVTKMEGRKVWIEGHIETLSSYSLFSNKGNKPVIIADATALFIEPKNSSLIKKIISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7PHA8</accession>
    <name>M7PHA8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="2">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873990.1">
        <property type="nucleotide sequence ID" value="XM_007875799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PHA8"/>
    <dbReference type="STRING" id="1069680.M7PHA8"/>
    <dbReference type="GeneID" id="19895704"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02010"/>
    <dbReference type="eggNOG" id="KOG3157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059988_2_0_1"/>
    <dbReference type="OMA" id="PLEWHMI"/>
    <dbReference type="OrthoDB" id="10264196at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06822">
        <property type="entry name" value="PLPDE_III_YBL036c_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000018">
        <property type="entry name" value="Pyridoxal phosphate homeostasis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00044">
        <property type="entry name" value="YggS family pyridoxal phosphate-dependent enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146:SF14">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine racemase N-terminal" evidence="5">
        <location>
            <begin position="28"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2 3">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="246" mass="27579" checksum="54746BB754A8856B" modified="2013-05-29" version="1">MSYVSRIEEICLGLKRVQDAIVSCSKGRDVRLVAVSKLKPVDDIKIAYDYGQRHFGENFVQEMIEKAKLLPLDCCWHFIGRLQTNKCKALASISNLWAVESLDSSKKAYLLNKALIDLKKSSGIDNHSRKLNVFVQVNTSCEEGKNGVSISDSMELCSYIINNCKELYLKGLMTIGSLSESNSEYNKDFEALAKCRDEITKSLGIELELSMGMSRDFELAIKMGSTNIRVGTDIFGVRPSRYMNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7PHF6</accession>
    <name>M7PHF6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peptidase M16 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_01646</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09884.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613305.1">
        <property type="nucleotide sequence ID" value="XM_019757733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PHF6"/>
    <dbReference type="STRING" id="1069680.M7PHF6"/>
    <dbReference type="GeneID" id="19895341"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01646"/>
    <dbReference type="eggNOG" id="KOG0959">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1661534_0_0_1"/>
    <dbReference type="OMA" id="LQSDCWR"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000012">
        <property type="entry name" value="Protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006963421" description="Peptidase M16 N-terminal domain-containing protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="9">
        <location>
            <begin position="66"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="10">
        <location>
            <begin position="229"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="11">
        <location>
            <begin position="413"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="12">
        <location>
            <begin position="777"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR09884.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1040" mass="121719" checksum="3BB93D5FB9214F54" modified="2016-03-16" version="2">MWNYFIFSLFLLFLQAESYKIQYNASNYFLDAKDKKNIKILFSDIEKPETHLSLYRVIELPNKLHVLLISDPRTQLSAASMDVGIGYYSDPDDIPGLAHFCEHILFMGSLKASTNINFFSYIKRHNGIYNASTRAEGTSYFFNIPSSYFELALDKFSSFFIAPLFSRSSVERAVHAVQSEFNLYKQSDSLRIQQIEKTLSSVDSPYNKFGIGNFQTLMVNPKNIGKDILEEVKTFYNTYYSSNLMKLVVASSESLDRLQELILKYFSEIPNKDIQRPVFTQKPFTDKTLGMQYWYKSSLNSIKMELTFSIEVQTNFRNTNPSEYFRYLIEHKSSDSLYLYLLEEGWIVSLTTCTENILFDLDFLRITLYLTPKGLAQYEEIIVAIFQYLKMLKDQGPQEWIFHELLRLGDMNFRFSPYIPSYKVISYLSMVMQKARSDYSDLLKFGFITKYSPENIINLLNSLHPDNYLLSISSNNKPSDWNLREHWLESEYKLESLPETLVQRSNNLPANNSFKLPKPNKYIPENYVIRPLSNEKVYKPYLEYTARFFRYWCKQDDTHSSPKTYLFLFFKIPNFSSTPIQKALINIYINILACNISEIKYYTEVAGSQVSIFPHKLGFQLFIFGYTDKLFVLYQDVLDAILEFEPTPFIFNLALKAVKDEIFPSLYDISTYLYTDGYWPSDEILSVLQKALAVGSPPENASLIIENSLKNIFSKQFYNPFYDFDARTSVLEEGNNFIFQLTRVNLEDLNSHIYYSLQIGEANNPKLLVLVNIIHLIISKISFDQLRTKEQLGYFLKVCYSQTLTMINYDIILTSERDPFYLEQRIIVYLYRLAAIIENITDEEFKDYIDSIIHKFSYKYENIFLEANFISSGIYNFDFSTMAIDVLKNLTKDDLKKFFYKYFYPDSPNRKKLSIHIRSGVLEEVSSSDLSLQRLYYYFKCNELEIPFDDLFTLAQSNPKLSNFEKSIQELLVKKYPDTDISIIVAQAFKYLENHYKELKQKALKNYNAVNILDPVVFKNSMKLSSVPPPLLSFEAYKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7PHS7</accession>
    <name>M7PHS7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vps72/YL1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01769</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS72/YL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873736.1">
        <property type="nucleotide sequence ID" value="XM_007875545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PHS7"/>
    <dbReference type="STRING" id="1069680.M7PHS7"/>
    <dbReference type="GeneID" id="19895463"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01769"/>
    <dbReference type="eggNOG" id="ENOG502RXYF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_598669_0_0_1"/>
    <dbReference type="OMA" id="GNIKEHR"/>
    <dbReference type="OrthoDB" id="3942062at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046757">
        <property type="entry name" value="YL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275">
        <property type="entry name" value="YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05764">
        <property type="entry name" value="YL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="4">
        <location>
            <begin position="388"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR10014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="457" mass="53136" checksum="43AA6F103CA39B09" modified="2013-05-29" version="1">MSSSEEETGESIESIEGLVKGREKRITAGNRLQALLDEEFVAESIFDVTDEQDEDFESDKNQLQDIEISESDEEESSSCSEGSEERAIERREKKIKKRKPPEAFFKARKQLKKEREESSVRKSSYKEISIVHPESIRHSSRPHTIENKNLIDHRLRESNKRRSRQNTYVKIKEKQMTQEERIAEAKITEEKSKELLQRLIKMEKEKKKNARNLLKTNKTLTSPFIRFLSKSIDKCLDEKIFSKKKEINQDKDVDIVKKNIGETIEHDHNANNWSLNTSEELSKTLEENIVKNNKETLEGDKEFIDNDDKTINTTLFQENDDESISIHFDDKQSKKISNKKTIIPTENFSEYISRNYIILEGFSEPFDLNKQKNILFSHTDPPIQPKKNLCLITGKVAKYKDPVSGLYYSDLSTYQTIYRIIRGDIPWSRIACTFVAALKPANGVPSDFHDSQPFQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7PIA5</accession>
    <name>M7PIA5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61</fullName>
            <ecNumber evidence="2 9">2.1.1.220</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_01467</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine(58) in tRNA + S-adenosyl-L-methionine = N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10365"/>
            <dbReference type="Rhea" id="RHEA-COMP:10366"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
            <dbReference type="EC" id="2.1.1.220"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="2 9"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873406.1">
        <property type="nucleotide sequence ID" value="XM_007875215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PIA5"/>
    <dbReference type="STRING" id="1069680.M7PIA5"/>
    <dbReference type="GeneID" id="19895163"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01467"/>
    <dbReference type="eggNOG" id="KOG2915">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025402_4_0_1"/>
    <dbReference type="OMA" id="PCIEQSL"/>
    <dbReference type="OrthoDB" id="1925287at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF2">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="12">
        <location>
            <begin position="2"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="204"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR10194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="292" mass="33869" checksum="6A2675C9D754213B" modified="2013-05-29" version="1">MGYLHILRPTPELWTRALPHRTQIVYTHDISFIQSKLRIQRGTTVIEAGTGSGSMTHALARGVGITGRVFSYEYHEKRYKEALSEFKQNQILAPKGPVILSYQDVITDGFCIKGYEVIAHAVFLDLPAPWKVICKLIPHFSKERQTKICCLSPCIEQVQKTLKHLRKSGFYDIELSEINHCEWIARKVEYKDILEAAQRIHEVQENRKNGKQPDNGDSRPQKRIKEGREDRNWKDVGRMEKNVKNHTSYLTFATWIPFSQDYQIPSDKNDVLYMKNDVENINYDTNNLETSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7PIN3</accession>
    <name>M7PIN3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873509.1">
        <property type="nucleotide sequence ID" value="XM_007875318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PIN3"/>
    <dbReference type="STRING" id="1069680.M7PIN3"/>
    <dbReference type="GeneID" id="19895255"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01560"/>
    <dbReference type="eggNOG" id="KOG1605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_669248_0_0_1"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000089">
        <property type="entry name" value="NIF domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009968991" description="FCP1 homology domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="FCP1 homology" evidence="3">
        <location>
            <begin position="229"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="411" mass="48169" checksum="B04B36AFDC8157F6" modified="2013-05-29" version="1">MKSFRIFLILFNKFRLGTAIDVKPVVSDFERISLYMRRGSKENGIFDRELKKESKSSEKKVYFWGFLTCFIVYINSLVLYLWSKLKGVYIYIYFMKKEFFKEREDTSSRSWLNIAVYFFLFPYFWISNGKKLIKSSFMSEFPYKGCSDFKSSRDSSNTQLSTQLFASQAENSLLFHNQDSSSNLIHFMLYNKDVIDKDNLKSPSSSMIIDMSQWSEFLHTSIPRPLFPKTLMPKTLILDLDETLIHSLVKGGRIATGHMVEVMLGKHAILYYVHKRPHCDNFLKKVSKWYNVVIFTASVQEYADPVIDWLEKDRKFFKARFYRQHCTFRNGSYIKDLSIVHPDLSKVIIIDNSPISYSMHEDNAIPIEGWISDPSDKNLLHLIPFLYGLRYVLDVRALLGLRTGVFSFNTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJ71</accession>
    <name>M7PJ71_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome biogenesis protein RLP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873133.1">
        <property type="nucleotide sequence ID" value="XM_007874942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJ71"/>
    <dbReference type="STRING" id="1069680.M7PJ71"/>
    <dbReference type="GeneID" id="19894912"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01215"/>
    <dbReference type="eggNOG" id="KOG1723">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089419_0_0_1"/>
    <dbReference type="OMA" id="TCYFCSG"/>
    <dbReference type="OrthoDB" id="10262490at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000001">
        <property type="entry name" value="probable ribosome biogenesis protein RLP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023442">
        <property type="entry name" value="Ribosomal_eL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF8">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01073">
        <property type="entry name" value="RIBOSOMAL_L24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="TRASH" evidence="6">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="181" mass="21435" checksum="1D73B143E32465E3" modified="2013-05-29" version="1">MRIYTCYFCSGPIYPGHGIMFVRNDAKEFRFCRSKCHKNFKMRRNPRKVAWTKAFRKARGKEMAIDTTLTFAARRNIPIRYNRDIVATTLKAINRVCEIRTRRERVFYKHHMAGNKTKLLEDAKKLIKMNPQQFPESEELMSNSQNILEEASQEKTEAIKIPLLSKKRKSIRFQIDDTNID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJK1</accession>
    <name>M7PJK1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="3 14">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PNEG_01339</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
            <location evidence="1 14">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="3 14"/>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873268.1">
        <property type="nucleotide sequence ID" value="XM_007875077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJK1"/>
    <dbReference type="STRING" id="1069680.M7PJK1"/>
    <dbReference type="GeneID" id="19895036"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01339"/>
    <dbReference type="eggNOG" id="KOG1057">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000914_3_1_1"/>
    <dbReference type="OMA" id="IQERWCC"/>
    <dbReference type="OrthoDB" id="18042at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052723">
        <property type="term" value="F:inositol hexakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052724">
        <property type="term" value="F:inositol hexakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000830">
        <property type="term" value="F:inositol hexakisphosphate 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000831">
        <property type="term" value="F:inositol hexakisphosphate 6-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052846">
        <property type="term" value="F:inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052843">
        <property type="term" value="F:inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052845">
        <property type="term" value="F:inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071545">
        <property type="term" value="P:inositol phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051516">
        <property type="term" value="P:regulation of bipolar cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110162">
        <property type="term" value="P:regulation of mitotic spindle elongation (spindle phase three)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000036">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11950:FF:000002">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="VIP1 N-terminal" evidence="17">
        <location>
            <begin position="37"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp fold RimK-type" evidence="16">
        <location>
            <begin position="247"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="567"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMR10639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="919" mass="106467" checksum="F7F2EDFFD2DF8365" modified="2013-05-29" version="1">MSLSADSVCSSFSEPITLSQPSSPPVSPGVKAKPKWIIGVCAMDQKARSKPCQNILNRLIQHGEFETVIFGDKVILDEEVENWPWCDFFISFFSYGFPLDKAISYVKLRKPFCVNDLPMQKVLWDRRLVMSILDSINVSTPYRIECSRDHGPKIEQGLADKLFENFGIRTNVIRNINYLKCIDEDTIEIDGKILKKPFVEKPVDGENHNIHIYYPKSKGGGGRRLFRKIGNKSSEFDPELSSPRTDGSYIYEQFMDVDNAEDVKVYTVGPHYFHAETRKSPVVDGFVRRNTYGKEIRFVTKLSEKECEMAKKICQAFSQMICGFDCLRVNGKSYVIDVNGWSFVKDNNEYYDNTSRILRQTFIDAARKKKPRIPSFGHTISSLSLEQNSWRIKGMFSVLRHADRTPKQKFKFSFKSEPFVELLQGHTDEVILRNEQLKMVISATEKAKQENCEDMEKLNQLHSTLLKKIGFLGTKVQIKPNYSIETGKLEKIQLILKWGGEFTHSARYQSKDLGENIRKDLILMNSDCLDDVKVFTSSERRVSASAEIFAMAFLDKEELPSGFLEVRKDLLDDSNAAKDNMDRVKKKLKTLLRDDLSARPQFTWPKDVPEPNEVMREVVELMKFHRTVMQHNFSAFSDKLDTFQTRWCCNENPFLFRERWEKLFCEFCDSEKVDPSKISELYDTMKYDALHNRPFLDAIFLPKDYHDFNKSEKLLSSDRENGTPREIGGPKMLPGLEKLRKLYRLAKILFDFVSPQEYGIENEEKLDIGLLTSMPLLKKLIKDINETKSSTRARCYFYFTKESHIYTLLNCIFESGIPTKISRNEIPELDYLTQINFELFERTTNSNFGTKEHSVRITLSPGCHSQDPLYMQLDAKHCISVAPRKSLTKHLDLQEICGKIEEKFQRVDLPKRFTPYVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7PK05</accession>
    <name>M7PK05_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA repair protein rad9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00908</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the rad9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872819.1">
        <property type="nucleotide sequence ID" value="XM_007874628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PK05"/>
    <dbReference type="STRING" id="1069680.M7PK05"/>
    <dbReference type="GeneID" id="19894606"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00908"/>
    <dbReference type="eggNOG" id="KOG2810">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030657_1_0_1"/>
    <dbReference type="OMA" id="NETQCRF"/>
    <dbReference type="OrthoDB" id="60092at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071479">
        <property type="term" value="P:cellular response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026584">
        <property type="entry name" value="Rad9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007268">
        <property type="entry name" value="Rad9/Ddc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04139">
        <property type="entry name" value="Rad9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009303">
        <property type="entry name" value="Cell_cycle_RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="387"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="413" mass="47958" checksum="CB9B092D1E6AE5BF" modified="2013-05-29" version="1">MNAVISGVYLKEFSKILFCLSKIGDELSIEARKNNLLLSSINSTKSVFGLVTFDSKRFFEKYEYFPYEQSYEISSKNNQSLKCRVQIRLLLAIFKARNLENRESKNVSVQKCELRIIRPNNIDRECRLIVRFLCKHGVLKTYKITYEQCQTMHALCNKSLCKNKWKIHSRTLKEYLDHFSSRAEELTLMSQNDKLLLTSFTEGLVYDKEILKQPIQTAILLDKRDFEEIYYEEQTIITFPLKEFKAVVTLGDSMNVLLNAYFNIGGEPILFEFEKNVLSIRFIFATTSDSSQENFAPYDLNKSSNSNNLHMHSQIHPHTNDYFSQNGTTLNNEINDSVMENYEENMHDNKKSVNPLSKDISSINNAFKKDKDTKHVSENIYYAGKMKDDTNETDSDDEVGPTQKETCIKSIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M7PK09</accession>
    <name>M7PK09_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872825.1">
        <property type="nucleotide sequence ID" value="XM_007874634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PK09"/>
    <dbReference type="STRING" id="1069680.M7PK09"/>
    <dbReference type="GeneID" id="19894611"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00913"/>
    <dbReference type="eggNOG" id="ENOG502SAS5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5054775at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021711">
        <property type="entry name" value="DUF3295"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053043">
        <property type="entry name" value="Ras-cAMP_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014:SF1">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11702">
        <property type="entry name" value="DUF3295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="1">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3295" evidence="2">
        <location>
            <begin position="93"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="515" mass="59360" checksum="195065BE5EB5E97C" modified="2013-05-29" version="1">MLSKPFSDPVLSLVSNSIEKLSILDLENLSRIWTVFAKSAENLENGYRLENLSWRLWYRTAFFCKENALSYINEADNDDSDKSIEYSKNKNFDIPELSTSIDSASTLDEHEIKHIPNYNTSKIPAFVQSRLKRPNTMQYVSPGRFQKIISDLSLFKLETEKWKNGNNKMVSKHDSREIRISDSPKENKIDYVSSKDSQSFTQSIEFSSNMHQSLTSNIDSIFPNEECLNLIERVGDIHEFSTNKISHETHVPHHSIQASKHLEKTDKIFFIQETLPAESYIETLSKNDFKSNALKLSSKSSFKPKSTKRISFEKLPSASSFETSNNEQFKYNIYNSIDNDDDNDWDSIYGSSSSSVTNEKPIFQKIDTRLLQLQLNPQRSLLSFMLQNKANGDLTNSCSKSSPAIALSQTSISFSISRQIPQNIQYHATRIEDQYSSMVSPRTIRRNMFATELSESLRKNLLWERQQRALTAYATLKRRHTEYDVTKLNGFPDRSNGGNYDFFYDVNYSYHVAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7PK79</accession>
    <name>M7PK79_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protein PBN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_01000</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872914.1">
        <property type="nucleotide sequence ID" value="XM_007874723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PK79"/>
    <dbReference type="STRING" id="1069680.M7PK79"/>
    <dbReference type="GeneID" id="19894698"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01000"/>
    <dbReference type="eggNOG" id="ENOG502QS8N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_585399_0_0_1"/>
    <dbReference type="OrthoDB" id="5546453at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042322">
        <property type="entry name" value="Pbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013233">
        <property type="entry name" value="PIG-X/PBN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28533">
        <property type="entry name" value="PROTEIN PBN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28533:SF1">
        <property type="entry name" value="PROTEIN PBN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08320">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00780">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR10854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="467" mass="54955" checksum="EF3E52FB8789FE67" modified="2013-05-29" version="1">MNLWRITYISEDKHETLSQFYSIERNEIFEKYMNLWKELKGVVSFPIKYSSELASYKLITIHWCRQDSCVRPPFATIPSNGIYIMIYPLDASKMTFSTLSFLKDLWKNKTPTWESFVDNKTGKLYYDSTISSSSFLLDLICMFNRHLCDQKDIESIGQIELFIYPSSKTIVVKIVWKLRLKSLDWNKYSKFLQNTSAHVEIGLLEPISNVTKRIKYLWRRAVLGQFNILEPYTTFFSNDFLDNSFIHSEVISSKGFHRKIRSKITISKLQNDTCSLYILYYLPKFVYVDKYQLENLVHFNIGNLKKIHFIRGETNLEAASWQLNKWGSLILVEALTHQNISFFVDLPIHLRYYLPMKNKFHTFNLSLPTSFYFCESLQDISTSQSPFSSSWQLFHDHFSKNGTFHFLHHSNHNYSTSMTIHIPVLNSSHILFVQIGTFLVILTSFLYILLKIFISSQKSGIFKHKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7PL97</accession>
    <name>M7PL97_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_00828</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine = N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10234"/>
            <dbReference type="Rhea" id="RHEA-COMP:10236"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8 9 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872735.1">
        <property type="nucleotide sequence ID" value="XM_007874544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PL97"/>
    <dbReference type="STRING" id="1069680.M7PL97"/>
    <dbReference type="GeneID" id="19894526"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00828"/>
    <dbReference type="eggNOG" id="KOG0820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041220_4_0_1"/>
    <dbReference type="OMA" id="PRMSMEL"/>
    <dbReference type="OrthoDB" id="74991at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052909">
        <property type="term" value="F:18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000007">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF7">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 9 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="11">
        <location>
            <begin position="36"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR11239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="221" mass="25195" checksum="E37D79DDFEE26BFA" modified="2013-05-29" version="1">MGKYREKNNTMQKAVSNNIFKLDKDIGQHILKNPLVIQGIVDKADLKPSDIVLEVGSGTGNLTIRILQKAKKVIAVEMDPRMSMELIKRVQTISEQKRLEMILGDVIKIDLPYFDVCISNTPYQISSPLVFKLLRQNPPPRLAILMFQREFAMRLLAKPGDSFYCRLSVNVQMWAKVTHVMKVGKNNFKPPPQVESNVIKIEPKVPPPPISFEEWDRSVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7PLN6</accession>
    <name>M7PLN6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_00391</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872265.1">
        <property type="nucleotide sequence ID" value="XM_007874074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PLN6"/>
    <dbReference type="STRING" id="1069680.M7PLN6"/>
    <dbReference type="GeneID" id="19894089"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00391"/>
    <dbReference type="eggNOG" id="KOG0201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="OMA" id="SCRIEEK"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000499">
        <property type="entry name" value="Serine/threonine-protein kinase KIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="8"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="446"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="526"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR11364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="677" mass="76285" checksum="6AB5F4EEB8B179DB" modified="2013-05-29" version="1">MTIAKPLYTLQELIGRGSYGAVYKGIHNETKQVVAIKVLNLDTTEDDVADIQREISMLSQLKQVDAQNVVRYHGSFLYDTRLWVIMDFCEGGSIRTLMKSCRIEEKYLSVIIREILIALNYIHRSGIIHRDIKAANILITNDGRVQLCDFGVAAQLTANNFKRNTFVGTPYWMAPEVITEGASYNFKADIWSLGITIYEIATGNPPFADQEPMRAIILIPRSPPTRLEGTQFSSQLKDFVAICLNEDVNERPSAMELLKTKFIKQTMKTPTSILKELLIRYELWCQHAGIRKSLNANVNDKINDENFEFDNMDNQFTEEWTFDTVQGYPDTKTFDIEDKNSLNKHEKDKIYLNETLKNKSPNSNNALNNTKMNHPLLQLFVQESEKTEPNTYITSSLINSSKNFTKTDDFKDELNQISIDISNIDLAPSLACSLQNDNLKSQQLNSNSLQPKIHSQTESSQISFNHHYSKSTQSNPVVSVDYLPRMIPTSPLQFPGSTPLKPSYSCSQSLNLPSKSTSSVFSSKIFPEPQLNSRQSSKSSNKNKHISVKDQSNTSNSMSHALDQKIPLLNTKSQTQNISPVSKYSGMDDLIFLPPSPSQPSISPNFHIPLKDSTLSSVWKNPPLIPLNLEVLSDYANSGGNTTNNSIINELEKVLLEFQNYLEVLDKGLSIIQKNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7PLQ6</accession>
    <name>M7PLQ6_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00413</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872290.1">
        <property type="nucleotide sequence ID" value="XM_007874099.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7PLQ6"/>
    <dbReference type="GeneID" id="19894111"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00413"/>
    <dbReference type="eggNOG" id="KOG2079">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000917_0_0_1"/>
    <dbReference type="OMA" id="HQACGLI"/>
    <dbReference type="OrthoDB" id="289913at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059070">
        <property type="entry name" value="TPR_VPS8_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025941">
        <property type="entry name" value="Vps8_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23410">
        <property type="entry name" value="Beta-prop_VPS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12816">
        <property type="entry name" value="TPR_Vps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25066">
        <property type="entry name" value="TPR_VPS8_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23413">
        <property type="entry name" value="zf_RING_Vps8_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 8 central" evidence="2">
        <location>
            <begin position="702"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="domain" description="VPS8-like TPR-like repeats" evidence="3">
        <location>
            <begin position="1261"/>
            <end position="1451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR11389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1582" mass="183949" checksum="0F49995513083249" modified="2013-05-29" version="1">MNLMEKKRDLKLQEIKENNSTKLELKDIIYENELDFSEKRSFFSEIIDGNKKKDNYKQLTSIFEKGVSFRNKHKKENKEDYDDYKNVENLSFLNVEKIHPSFSGNFENKSETFFQKSASYSSFLLKDDTNSFKHSRTQSLMSLSSINPACFNYSLDSLISSSFEDSKDGERSFNFEDAICWSKLKEINSQIFTEFSKEKFGSPVSMSISNIIAIGTSKGLILVFDYRQVLRHIIGMGTKAMDSGSTTSISISDDCMFLCSGHSKGYIFVWELRIPTNPVITISPIVSDAFQNIHNNGHLDNSKICHIAFVNSYYSIVSSDIHGMTFYHILNRTIISNSLLSIRLAGHYLTSPSFKKSDIILALTSLSMKNSKKSSDSIILIAILTSYKLSIISTTPVLKTQFIMTKPKSLKISEYTLGTLSWFSCEKFKKNDIENTDINKNKIRLLCSRENHLFVIEIRKKASEHGNSKDILPLSFKTISEWKEREPVLASQWFNMTILVILSKSQEIFIINVETMESFFSCNISSKGVLVMDPFNDELIQNKMTNKSSERNLMTSTMFCQSFFIFKKKFFLLCKDNVFIGILPNWEHKLSLVISSKEFIKAISLMNLYYKGNCEKIILGLPLDDDLRHELLQEKLLKTIDTSLEIILDENSSSLKNNIISNRQIKKKLAFVCIEACINMKITDFLFNDIYDRFKKTKNDEIFLESLETFILIMGLKIIHPNVMKDMIVGLLKKKLYLRLKDIIFKIDFISLDIQETLKICHKEELYDILIYIWTQAFNDFITPIIHFLGLIVFFLKNKNIQINQEQKNNSFSEDIDILASQINELFLYLSHSLSGRIYPIGLDMNKNISFLAKSSIYWFIFSGTNIIWPKNNGILIKLNTDDSQELTFPYLRLILNYNAQAFLSLLDDVFGDNFLNEIDNNSKSSSFSEIKITRQLIINILLEIMQEETYSQSIIYLYIFIASSISKYRQFILLSGSVLEKILIGLAKNSNQDISDQCQLSINYILSFYRPNDIDYLINLYEKVGFYKVLKFIYKQEKMFLKLLKIHIEDKSEPNELFRCIKELFQLQNQSKNKKILKIHKIILEYSEEICSIDATRFSLIVDKYLPELHTKILKKLKIPIIQYNYLKCILNSSELLINKENVSSEDDIIALNDQNNSKIWITKDILELFINFLCSFEIEKVTDYIKSLNINDIDVDNVLLILENYRIIDAIVYLLSLEGKNIIAFEKILEYIAESMLEIDMSLKLETYVNDINALDFNHIKKQLGNVEKNIITGIYLCEQYFLEINSKKNQIFQDSLNPFDLSLLNSKFQWIKLLEVIIKISQIMLTKLSNQFLKMSSENLSYNLTENKSLLKISNISEKIGTFMQNSIQNIFTSLYNLTSLSNSHSIIFLHVLEQFFEIITSLSLPILEFKELLINIFKNYKYDERLLIIINSILHKDLFKLMKYDNQIKKKGSKVQFNSCGVCEKDIWNPEDIISFLHSFGEKKQQEEVLDVKQEHSYSLIKKGDNFIPSFEEKKIIGKKKMHTKQNSADLLEYKDLFIENEVFPKIIVFMCGHNYHENCLYNIQKRRDFTCILCGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7PLY4</accession>
    <name>M7PLY4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">quinol--cytochrome-c reductase</fullName>
            <ecNumber evidence="3">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PNEG_00494</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
        <text evidence="17">Binds 1 heme c group covalently per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872380.1">
        <property type="nucleotide sequence ID" value="XM_007874189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PLY4"/>
    <dbReference type="STRING" id="1069680.M7PLY4"/>
    <dbReference type="GeneID" id="19894192"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00494"/>
    <dbReference type="eggNOG" id="KOG3052">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040334_1_1_1"/>
    <dbReference type="OMA" id="WVKKFKW"/>
    <dbReference type="OrthoDB" id="5925at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000002">
        <property type="entry name" value="Cytochrome c1, heme protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000003">
        <property type="entry name" value="Cytochrome c1, heme protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002326">
        <property type="entry name" value="Cyt_c1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021157">
        <property type="entry name" value="Cyt_c1_TM_anchor_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266">
        <property type="entry name" value="CYTOCHROME C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266:SF3">
        <property type="entry name" value="CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02167">
        <property type="entry name" value="Cytochrom_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00603">
        <property type="entry name" value="CYTOCHROMEC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81496">
        <property type="entry name" value="Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 17" id="KW-0349">Heme</keyword>
    <keyword evidence="13 17" id="KW-0408">Iron</keyword>
    <keyword evidence="15 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR602326-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMR11479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="294" mass="33443" checksum="0B24C4B98DD033B7" modified="2013-05-29" version="1">MWFNFSRKFFYSYKAKIGQTGSQTVVLTLSTFTSLSSAFLYYYIYGNPIKAMTPEEHGLHPPKYPWPHKGFLSSYDHKSLRRGYQVYKEVCSACHSLSLVAWRNLVGVTHTVDEVKAMAEEHEYEDGPDDNGNMFMRPGKLFDYMPSPYPNEEAARAANAGAYPPDLSLIVKARHGGCDYIFSLLTGYMDPPAGVVLSDGMNYNPYFPNGQIAMARTLFDGLIEYDDGTPATTSQMAKDVVSFLNWAAEPEHDDRKRMGFQTLIILSTLFALNLWVKRFKWAPLKTRKIVYNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M7PML5</accession>
    <name>M7PML5_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872004.1">
        <property type="nucleotide sequence ID" value="XM_007873813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PML5"/>
    <dbReference type="GeneID" id="19893841"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00143"/>
    <dbReference type="HOGENOM" id="CLU_2942803_0_0_1"/>
    <dbReference type="OrthoDB" id="2330118at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="60" mass="7151" checksum="7244AEED7842DB16" modified="2013-05-29" version="1">MAETMLQEELGYLRILRATLESLRKITERISYDIQTTCENYQDIIELNKRWKRIADDTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWW4</accession>
    <name>A0A0W4ZWW4_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_04326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="KTW32866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613344.1">
        <property type="nucleotide sequence ID" value="XM_019757838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWW4"/>
    <dbReference type="GeneID" id="30671600"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04326"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KTW32866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="92" mass="11419" checksum="761AC66F56CEC32C" modified="2016-03-16" version="1">MTYSCQLLIIFYVLKNEHKISFYFNNLKKLNYIGKKCKDIMNIIFLWFLKIILIFENRLSYKKPFNSNSNFNYKITIKKMNYTKPSEYYWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZX10</accession>
    <name>A0A0W4ZX10_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_04280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="KTW32911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613383.1">
        <property type="nucleotide sequence ID" value="XM_019757801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZX10"/>
    <dbReference type="GeneID" id="30671572"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04280"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KTW32911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="79" mass="9157" checksum="2A0B8FE9268998DE" modified="2016-03-16" version="1">MSHLYIFSKPNISSSIGIKIGIENHNFKGKSLNNNEIIEIYANLFYAILLPIHSFFTKNRGFFVFIDLSQIKRYTSIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZX33</accession>
    <name>A0A0W4ZX33_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_04269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="KTW32932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613401.1">
        <property type="nucleotide sequence ID" value="XM_019757792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZX33"/>
    <dbReference type="GeneID" id="30671564"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04269"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KTW32932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="72" mass="8235" checksum="77C8748F86B55662" modified="2016-03-16" version="1">MLEEIYYAFNKSPLLFAKSVNISDVDNISVIINGMFFQCIFKHVRKNSSGSYLIRSIPKATLIEETDLMTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZX34</accession>
    <name>A0A0W4ZX34_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Major surface glycoprotein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_04005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="KTW32924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613393.1">
        <property type="nucleotide sequence ID" value="XM_019757764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZX34"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZX34"/>
    <dbReference type="GeneID" id="30671541"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04005"/>
    <dbReference type="OrthoDB" id="5423421at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021041">
        <property type="entry name" value="Maj_surf_glycoprot_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003330">
        <property type="entry name" value="MSG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46345:SF8">
        <property type="entry name" value="FORMIN 3, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46345">
        <property type="entry name" value="INVERTED FORMIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02349">
        <property type="entry name" value="MSG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12373">
        <property type="entry name" value="Msg2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Major surface glycoprotein 2 C-terminal" evidence="2">
        <location>
            <begin position="903"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="761"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1068"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="761"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="853"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="864"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1076"/>
            <end position="1096"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KTW32924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1119" mass="125298" checksum="0D84538833006CE5" modified="2016-03-16" version="1">MARPVKRQAAGQAAGNDEIKEEQVLGLIVKSDYSDDNKCKANLKHYCEELKKIDGKLESVDVKVKGLCENIDKKCGDLKDKVEKELNSFKTEVEKELNNLTDEKCRKYEEKCLLLEEADPSNLEEKCVKLRDRCYRQRRQGVAKEILLRALEGKVNDTNECKKKMKEICQGLSEYSDELVFSCFNPDETCEYFRKNHGDNCKPLQKELEDKELVEKCQEYLEKCYFYGSSCKDTKCDKVKNKCKGKGIEYEGPKLDFSPVKEKPRFPEKIEVENLYKKEEAKGIIVGKPKYKTLRDLALLLIKGRNGNSPEEKCKEALKDCESFKHLDYGLGELCGDKDKDNKCKELVEVEDRCTNFKLELYIKGLSTKFEDIESDYFSWGQVSKSVSREDCIKFESECFHLEGVCTNGIVKACENVRVACYKKGQDRVLNRYFQEGLKGLIGDLELVTENLEKCQKSVVGNYTKLKEDRRYFTKCHRPTELCYELLDDVILQSEELEVVLNLRRDFPRKEDCVELKKKCKDLESDSYLNHEKCNTLNRRCEYLKVTEELRKRLLKRGDDALRTQGNCTAVLKKECEELSRRGKDEFSVSCALREETCSFMVEQTENECLFLKNNINNEKIIDKIENGNETLVEELCTLFDPYCHQYIENCPDRLKKEKNSNKNGVCLQLEEKCKPFFEKLKLENELTHELKGSLSDETECKKALGKHCTEQKDLANKKFNSFCNTDKDKGVEEKVCKKLVEKVKRKCPTLEDKLDKEKDELKKKKDEYEKVKQESEKFTKEAKLVLSKPEQDGQGGGSKAQDGSAPKPVGPPVQPPAPAQPTPGGVPAPTLAPPAQPTSGGAPLPVPPAAPAGPAAPGTPSTPSTPPAPAGPAGPAGPSGGTPAGPPAPGGSTPSGTTNTSNVILVRRTFVSGEVSEPEKKAFVATARALELYLELKEKCKSLKGDCEFRKDCPGCKAACKEIDELCEGIEGLKVTPHHTVTSTATQTTTTTATTTTTTTTTTTTTTTTTTTATTTESVDGGKVTEECTLVQTTDTWVTSTSLHTSTLTSTSTVTSTVTLTSMRKCKPTRCTSDSSKETETQKEEEKEEEVKPNEGMKIRVPEMIKIMLLGVIVMGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M1FPY2</accession>
    <name>M1FPY2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase chain 2</fullName>
            <ecNumber evidence="3">7.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NADH dehydrogenase subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">nad2</name>
    </gene>
    <organism>
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="12"/>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="FASEB J." volume="27" first="1962" last="1972">
            <title>Sequencing and characterization of the complete mitochondrial genomes of three Pneumocystis species provide new insights into divergence between human and rodent Pneumocystis.</title>
            <authorList>
                <person name="Ma L"/>
                <person name="Huang DW"/>
                <person name="Cuomo CA"/>
                <person name="Sykes S"/>
                <person name="Fantoni G"/>
                <person name="Das B"/>
                <person name="Sherman BT"/>
                <person name="Yang J"/>
                <person name="Huber C"/>
                <person name="Xia Y"/>
                <person name="Davey E"/>
                <person name="Kutty G"/>
                <person name="Bishop L"/>
                <person name="Sassi M"/>
                <person name="Lempicki RA Kovacs.JA."/>
            </authorList>
            <dbReference type="PubMed" id="23392351"/>
            <dbReference type="DOI" id="10.1096/fj.12-224444"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 2 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="JX499144">
        <property type="protein sequence ID" value="AFR90416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_007475006.1">
        <property type="nucleotide sequence ID" value="NC_020332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M1FPY2"/>
    <dbReference type="STRING" id="1069680.M1FPY2"/>
    <dbReference type="GeneID" id="14657965"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00445">
        <property type="entry name" value="NDH1_NuoN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010096">
        <property type="entry name" value="NADH-Q_OxRdtase_suN/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22773">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="365"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:quinone oxidoreductase/Mrp antiporter transmembrane" evidence="11">
        <location>
            <begin position="126"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFR90416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="478" mass="53351" checksum="EF7D2F96CE5D78DC" modified="2013-05-01" version="1">MLLLSIIGQLIAIAFSSPHWNLVLLSRISILSLIYSIFLTYNVYYVDLLGSGLGIYSGFLQVTSLTQFIDVFISLLGICILGITGFYSIDKKNSRELTNLFDFKQILEYPLLSIFLLLGSQLIISSLNMISFYLSLELQSFSLYILSSLYSSKHGLKYYFLGALSSCFVLLGLGLLYSYTGITSLESLAIFNEVNTNIYLQISILILISGILFKVASVPFHQWAIDVYDGVPTIITTWLTTLTKISLLIFLMEFLSSTSSSSGLTILTFLSVLSIVVGSLLGLSQSRIKWLLIYSMVSHVGFLILSLSILQEKSLEAFLFYLVQYSLTNLNIFLILIAMGYFCNNPDSEDSPIMYIKSLRGFTKVNSLLSICFTISLLSLGGIPPFIGFFGKFNILYNTVSQGYLFITIIILLASVLSISYYLKVIQSIFFGESTSSFNNIQISTYLSTVISLLTLTILVFLIYPDLLLQLVHLTICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7NI43</accession>
    <name>M7NI43_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_03396</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875481.1">
        <property type="nucleotide sequence ID" value="XM_007877290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NI43"/>
    <dbReference type="STRING" id="1069680.M7NI43"/>
    <dbReference type="GeneID" id="19897083"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03396"/>
    <dbReference type="eggNOG" id="KOG0178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_4_3_1"/>
    <dbReference type="OMA" id="YVLNDNM"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080129">
        <property type="term" value="P:proteasome core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03752">
        <property type="entry name" value="proteasome_alpha_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000031">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="249" mass="27669" checksum="30598195BC13475D" modified="2013-05-29" version="1">MSRRYDSRTTIFSPEGRLFQVEYALEAISHAGTALGVMSVDGIVLAAEKKIINKLLEKNISTEKIYIIDDHMICAVAGITADANILINYTQRIAQQYLLTYGNNMPCEEIVKSLCNVKQGYTQYGGLRPFGVSFLWAGYDPIRGFQLYQSNPSGNYGGWKATCIGANSASAQSLLKQDYKETSLKEACSLAIKVLSKTVDSTTLSNEKVEFATIGTNKQGKIYHHIWTPDEIDTLLKENKLLEDIETET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M7NI65</accession>
    <name>M7NI65_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA replication ATP-dependent helicase/nuclease</fullName>
            <ecNumber evidence="20">3.1.-.-</ecNumber>
            <ecNumber evidence="20">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PNEG_03415</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 20">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="20"/>
    <dbReference type="EC" id="3.6.4.12" evidence="20"/>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875501.1">
        <property type="nucleotide sequence ID" value="XM_007877310.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NI65"/>
    <dbReference type="GeneID" id="19897102"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03415"/>
    <dbReference type="eggNOG" id="KOG1805">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001666_2_2_1"/>
    <dbReference type="OMA" id="NYCEAAI"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071932">
        <property type="term" value="P:replication fork reversal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18041">
        <property type="entry name" value="DEXXQc_DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22318">
        <property type="entry name" value="DNA2_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000789">
        <property type="entry name" value="DNA replication ATP-dependent helicase/nuclease DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001170">
        <property type="entry name" value="DNA replication helicase Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026851">
        <property type="entry name" value="Dna2/JHS1_DEXXQ-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014808">
        <property type="entry name" value="DNA_replication_fac_Dna2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF433">
        <property type="entry name" value="DNA REPLICATION ATP-DEPENDENT HELICASE_NUCLEASE DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08696">
        <property type="entry name" value="Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 20" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="20" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 20" id="KW-0227">DNA damage</keyword>
    <keyword evidence="16 20" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 20" id="KW-0235">DNA replication</keyword>
    <keyword evidence="15 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 20" id="KW-0347">Helicase</keyword>
    <keyword evidence="10 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 20" id="KW-0408">Iron</keyword>
    <keyword evidence="14 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18 20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 20" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Dna2 N-terminal" evidence="21">
        <location>
            <begin position="291"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="22">
        <location>
            <begin position="854"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="22">
        <location>
            <begin position="963"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="23">
        <location>
            <begin position="1032"/>
            <end position="1247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU367041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF08696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EMR08248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1316" mass="153374" checksum="1EB6D26B84C5ADEE" modified="2013-05-29" version="1">MEYLVNQLKTFLPEPWKRLHTQKTSVSLPSEDMQLPKQAMEMKMHTEIEKDNEEFFMEEQMLFQKEEAFDEFSETLSDEIEEISKCFDRNIKENTKEMERIVVFDNPLIEKSEEIGRKHEELSLEANQVNIDFLKNYTEKNNEKSSERNEVNKLSENFSLEADPVQTSSSDDILDDSFTDDMLDEEIEAVLSALDTCKEVDIEEVKAKSVELDVPEEQYIFEKNKNEIFASNVKNEMVSDYYSKNMSLKEYDACNDEKKNHSFLNYKVYNIKEEPWIDSNGYKGLQKVVLSQEKQTILLRQDWFFTPIEIGDYLYLHGEYDENGICIVDNSHFLVILNPDFLVSCTSVATSYSCIRRIILQERVKITDSISKSQIYGKILHRLFQLCLENDNFSLSFLKEKTKQLVLDNLEHLDIVGETIENAMKHISGKFSNLQKWASKYFLNTPEENLYIKSFRSRRSDTSHISINKLLRAEEHILSPKYGLKGYIDVTVQLAVKSDIDLQYSIAPFELKTGNNIYVMQHRAQTILYTLLLSEYYGKNVEFGLLFYLEKGETIQVFPVHDEIRGLIITRNNIAKYLKNNQELPSMLKNMFVCKKCPMRKPCFVFHKAIELGTAETSGLGQYFDDETNSITSKDSYFFQYWDFILSKEENEIFRFRKELWTMTSKEREKHGRCLSNLKIKKIHSISEEEILGYIDHYVYTLEKCSSSNNDDSLLNSEISYNDFIIVSDENGHYALAYGTVINIEPKFITISLNQQLYSPTSILSDHDVQYTQIPKSSMLKVFKNDFNKLDDKNILYRIDKDEFKSGISLARDNLTKLLYLEQEKRRRELIINLYPPKFNSILTDFFKIPEYEKLNNDQKKAILKVMTALDYTLILGMPGTGKTTTITYLIQILIANNNTILLASYTHSAIDNILLKLNIKKENVLRLGSIERIHPDLRKKIITEEYVVNDSESFQLKYIRPSIVATTCLGITHSIFSRRTFDYCIIDEASQIVLPICIGPLRFSKKFVLVGDHYQLPPLVRSIDVANQDIETSLFKHLLDTNPSAIVNLEYQYRMNKDIMLLSNTLIYDGKLKCGDEKIAYKLLDCGDFQMLDALHLKEGNEFACNINECWIKKILEPRLSVVFANTDYVPAPESRKGDRIQNEVEVQLLKQVIICLLNQGISESDIAVLSVYRSQIKLIQHHFRHFEKIETDTADRFQGRDKNCIIISFVRSNDKNEIGELLRDWRRLNVAFTRAKLKLIFFGSKSTLEKTGIFNLFFDLLKQKQWIYHLPKNAHLLHFLDDFIKQTNIKKLPKKKIDHISKNCSLLKTIMHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M7NIN8</accession>
    <name>M7NIN8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_03287</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875361.1">
        <property type="nucleotide sequence ID" value="XM_007877170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NIN8"/>
    <dbReference type="STRING" id="1069680.M7NIN8"/>
    <dbReference type="GeneID" id="19896974"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03287"/>
    <dbReference type="eggNOG" id="KOG1744">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075666_2_1_1"/>
    <dbReference type="OMA" id="FCPFAIR"/>
    <dbReference type="OrthoDB" id="10254238at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000014">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="29"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR08458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="135" mass="15026" checksum="8F0424628CA8419F" modified="2013-05-29" version="1">MPQKPAEKKPVAGKGFSGKVPLEKRNVSDKLHSDRKKRLKSRKETYSSYIYKVLKQVHPDTGISNRAMSILNSFVNDIFERIASEASKLASYNKKSTISSREIQTSVRLILPGELAKHAVSEGTKAVTKYSSSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NIW6</accession>
    <name>M7NIW6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Brix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_03029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08548.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875080.2">
        <property type="nucleotide sequence ID" value="XM_007876889.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NIW6"/>
    <dbReference type="STRING" id="1069680.M7NIW6"/>
    <dbReference type="GeneID" id="19896716"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03029"/>
    <dbReference type="eggNOG" id="KOG2780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040063_1_0_1"/>
    <dbReference type="OMA" id="EWEHRPD"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="84"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08548.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="291" mass="34571" checksum="B90B3D33131BE8E6" modified="2016-03-16" version="2">MHAKNYEKFRRIYSKKSRVLMGEKISKKRGKTREKQEHFEVKKTDTIESKREKRGNVFPEENIEIYEDIKKNELKSITDSDYTPKILIITSKKSSKNTYFFAKELVGLFPYSTLIRRDIQFEIKKITEYSIKRKYTSLIFINENRKKPDSLIIINLPSGPSFYFTLSSIMPTSCIYRHGRATSHVPELIINNFSTHLGLIVENLFRSLFPVQADFEGRQVVTIHNQRDFIFIRRHRYIFKNDIKVSLQELGPRFTLKLRRVQRGIHDREAGNVVYEYKPGEESNRSRFWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJ04</accession>
    <name>M7NJ04_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pre-mRNA-processing-splicing factor 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_03064</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875120.1">
        <property type="nucleotide sequence ID" value="XM_007876929.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NJ04"/>
    <dbReference type="GeneID" id="19896751"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03064"/>
    <dbReference type="eggNOG" id="KOG1795">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000380_3_0_1"/>
    <dbReference type="OMA" id="ANKWNTS"/>
    <dbReference type="OrthoDB" id="1931567at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000386">
        <property type="term" value="F:second spliceosomal transesterification activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000389">
        <property type="term" value="P:mRNA 3'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08056">
        <property type="entry name" value="MPN_PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13838">
        <property type="entry name" value="RNase_H_like_Prp8_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.230:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000002">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1570.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.40">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012592">
        <property type="entry name" value="PROCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012984">
        <property type="entry name" value="PROCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021983">
        <property type="entry name" value="PRP8_domainIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043173">
        <property type="entry name" value="Prp8_domainIV_fingers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043172">
        <property type="entry name" value="Prp8_domainIV_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019581">
        <property type="entry name" value="Prp8_U5-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042516">
        <property type="entry name" value="Prp8_U5-snRNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019580">
        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08082">
        <property type="entry name" value="PRO8NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08083">
        <property type="entry name" value="PROCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08084">
        <property type="entry name" value="PROCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12134">
        <property type="entry name" value="PRP8_domainIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10597">
        <property type="entry name" value="U5_2-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10596">
        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="MPN" evidence="7">
        <location>
            <begin position="2107"/>
            <end position="2238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="2340" mass="273097" checksum="B4CFEA0A26D65B1B" modified="2013-05-29" version="1">MSLPPGFRGAVNGMEMKIKDPIQIQLDEKARKWRQSQRHRFEEKKKLGYIETQKAELPAEHLRKIIKDHGDMSSKKFRHDKRSYLGALKYMPHAVLKLMENMPMPWMEVKYVPVLYHITGAITFVNEIPRVIEPHFIAQWGTMWIMMRREKRDRRHFKRLRLPPFDDEEPVIDYGENIADVEPLEAIQMELDPKEDGAVNEWFYEHKALLDTVHVNGPTYKRWNLNLAQMSTLYRLAHQLLSDLTDQNYFYLFNLNSWITSKSLNMAIPGGPKFEPLHKDTLDMDEDWNEFNDIYKLIIRHQIRTEYKVAFPYLYNSYPRSVRLSIYHEPSTTYIRTEDPDLPTFYYDPIINPISMRSFIESLPIGLHEDNIFQGEEVDTFRLPENLESFLNDVPLYTENTSMAIALWWAPHPFNKRTGRMIRAEDVPLVKQWYLEYCPPGQPVKVRVSYQKLLKNYVLNALHTKPPKSHLKKDLFRQLKNTKFFQTTTIDWVEAGLQVIRQGYNMLNLLIHRKNLNYLHLDMNFNLKPVKTLTTKERKKSRFGNAFHLMREILRLMKLLVDSHVQYRLGNIDAFQLADGIHYCFNHIGQLTGMYRYKYRLMRQIRTCKDLKHLIYYRFNTGPVGKGPGCGFWAPSWRVWLFFMRGIVPLLERWLGNLLARQFEGRHSKGIAKTITKQRVESHFDLELRAAVMHNILDQMPQGIKANKSKTILQHLSEAWRCFKANIPWRVPGLPAPIEQIILRYVKAKADWWISVAHYNRERIRRGATVDKTVAKKNLGRLTRLWLKAEQERQHNYLKDGPYVTAEEAVAIYTATVHWLESRKFSPIPFPPLSYKHDTKLLVLALERLKEAYSVKGRLNQNQREELILIEQAYDNPHECLSRCKRFLLTQRAFKECGIEFMDQYSYLIPVYDVEPMEKITDAYLDQYLWYEADKRHLFPSWIKPSDSEPPPLLVYKWCQGINNLSEVWETDQGQCNVILETSLSRVYEKIDITLLNRLLRLVVDSNIADYISGKNNINLTYKDMNHINLYGLIRGLQFSSFVFQYYGLIIDLLILGLHRASEMAGPPQMPNDFLQYRDIATEILHPIRLYSRYIDKIHIFFRFTADEARDLIQRFLTEQPDPNNESIVGFNNKRVWPRDCRMRLMRHDVHLARAVFWDVKNHIPRSLTTIEWSDSFVGVYSKDNPNLLFSMCGFEVRILPKIRSATEEFTLKDGVWNLVNEQTKERTAQAFLRVTKDDMAKFNNRIRQILMSSGSTTFTKITNKWNTALIALLTYYREAVVSTPELLDLLVKCETKIQTRVKIGLNSKMPSRFPPAVFYSPKELGGLGMLSMGHILIPQSDLRWSKQTEAGITHFRSGMSHEEDQMIPALYRYIITWESEFIDSQRVWSEYAMKRQEAIQQNRRLTLEDLEDSWDKGIPRINTLFQKDRHTLSYDKGWRVRTDFKQYQLLKNNPFWWTSQRHDGKLWQLNNYRTDVIQALGGVEGILEHTMFKATGFPSWEGLFWEKASGFEESMKYKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGIYMHGKIPTLKISLIQIFRSHLWQKIHESIVIDLCQVFDQELETLQIETVQKETIHPRKSYKMNSSCADILLFATYKWNVSRPSLLNDSKDVLDGTTTNKFWLDIQLRFGDFDSHDIERYTRAKFLDYTTDSQSIYPSPTGLMIGVDLAYNLHSAYGNFFPGLKPLIQQAMAKIMKVNPALYVLRERIRKGLQLYSSEPTEPYLNSQNYSELFSNQIIWFVDDTNVYRVTIHKTFEGNLTTKPINGAIFIFNPRSGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQIVVTRKGMLDPLEVHLLDFPNIIVKGSELQLPFQAALKVEKLGDMILKATGPQMVLMNLYDDWLQTISSYTAFSRLVLILRALHVNMDKTKMILRPSKEIITETHKIWPTLTDQQWIDVELALRDLILGDYGKKNNVNVASLTSSEVRDIILGMEISAPSIQRQQITEIEKSQQEQSQLTARTTKTTNIHGDEIIVVNTSNYEAQTFSSKTEWRIRAISTTNLHLRTNRIYISSDDIQDQEQYTYIIPMNILKKFIIISDLYTQVAGFLYGASPSDNAEVKEIKCIAIVPQLGSNAGVQLPHKLPKHEFLLDDLEPLGWVHTQSHEMPHLSPNDLTIHSRIMAEHKEWDSKTITMTVSFTPGSVSLAAYCLTSSGYEFGAKNKDMTSGNPQGWVPTMAEKCQLLLSDRIVGFFLVPEDDIWNYSFNGANFSDKATYHMKLDVPIPFYSPQHRTTHFSSMMQLENEDTLLGDRTDVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJF5</accession>
    <name>M7NJF5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Replication protein A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02917</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874958.1">
        <property type="nucleotide sequence ID" value="XM_007876767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJF5"/>
    <dbReference type="STRING" id="1069680.M7NJF5"/>
    <dbReference type="GeneID" id="19896604"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02917"/>
    <dbReference type="eggNOG" id="KOG3108">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051033_1_2_1"/>
    <dbReference type="OMA" id="WLEMETI"/>
    <dbReference type="OrthoDB" id="25571at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04478">
        <property type="entry name" value="RPA2_DBD_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014892">
        <property type="entry name" value="RPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF16">
        <property type="entry name" value="REPLICATION PROTEIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08784">
        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication protein A C-terminal" evidence="5">
        <location>
            <begin position="76"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="187" mass="21135" checksum="322025D252373D72" modified="2013-05-29" version="1">MEDGTGLIEVKQWLEMETITDDNPKKNIDITPDTYVRVIGQLKSFNNKRHIYAHHIRPISDLNEVQYHILETTAIHLYFTRGPPQNNDSSKPFTTIDRNSSNYGIHDPMNINEMLGAQFSLRNLSPYLQKVMAAVHAAPNTNEGVNIHQLAKTIGGGNIERAIEELTNDGLLYTTIDDEHVKSTIQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NKE0</accession>
    <name>M7NKE0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02447</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874455.1">
        <property type="nucleotide sequence ID" value="XM_007876264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NKE0"/>
    <dbReference type="STRING" id="1069680.M7NKE0"/>
    <dbReference type="GeneID" id="19896140"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02447"/>
    <dbReference type="eggNOG" id="ENOG502QS1N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_454242_0_0_1"/>
    <dbReference type="OMA" id="YHENKIN"/>
    <dbReference type="OrthoDB" id="5588096at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005826">
        <property type="term" value="C:actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902716">
        <property type="term" value="C:cell cortex of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022018">
        <property type="entry name" value="GIT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039892">
        <property type="entry name" value="Spa2/Sph1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056439">
        <property type="entry name" value="VBS_C3G9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601:SF0">
        <property type="entry name" value="PROTEIN SPA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601">
        <property type="entry name" value="SPA2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12205">
        <property type="entry name" value="GIT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23742">
        <property type="entry name" value="VBS_C3G9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C3G9 VBS-like" evidence="3">
        <location>
            <begin position="272"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="ARF GTPase-activating protein GIT1 C-terminal" evidence="2">
        <location>
            <begin position="479"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR09103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="601" mass="68344" checksum="06C967637EAC89B0" modified="2013-05-29" version="1">MIEEGSDVEISPIKASISSNSFRLDAAASQELSRSLDKKTEDYNLRLKEIDYHENKINSKKQTINNKTESIDNIRKNEPSTDYEYRIVSLQNKIFSLESQLNIVNAKLAESEQELSLIKKTYEKNVEDEIQLRKTLEINLKELQQSNKILNEEIQILNEKQDTLNKNNEKYQLLLVNYEKLKSEMEEQQRVTNEVKREAREFLKEMKSLSEKETCSWQQIEALSQQVSFLQDEVKEWKNQYSKAKSQLLGLKATSYTEPLKFKTNYENCVEEHGVISNIAITNFQIAIDDLLHAGRSLEHKSVLEAMKDVIVSIKSINMNLEDNKHKSIFNDPQKSSAIAKLKSRMSATTNNLMIASKNHALNKGLSPVSLLDAAAFHLTATVIELVKLVKLRPPIITDSPEELNDNFDNTKEPPINPSLTQTNLDVLEDKTSEILSKNTDIHDICSTNTNTSKMPKTSVLKAVIDSDFDNNLDDFKTFLETKTEDIVELIQSLLSSVRADAQIKKLKDHMTKITSIVQSVVSKTFQVIAIENDENLREKISTIVNGLISCCSRSEELLGDKIENINIDKLFKQKLAGIAFDIAKQTKELLRTINGDNENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NL16</accession>
    <name>M7NL16_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02297</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874292.1">
        <property type="nucleotide sequence ID" value="XM_007876101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NL16"/>
    <dbReference type="STRING" id="1069680.M7NL16"/>
    <dbReference type="GeneID" id="19895990"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02297"/>
    <dbReference type="eggNOG" id="ENOG502S6CR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107213_0_0_1"/>
    <dbReference type="OMA" id="KYWQNEP"/>
    <dbReference type="OrthoDB" id="409928at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000006">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR09343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="17131" checksum="B127BDC4198E650B" modified="2013-05-29" version="1">MPSLHYLCSHLQNASRAYLAQTSLPATKLNLDICLGLYTHGLLGSVRRGSYCGPDTVYTPTTFDNISTRRIWVDLKYQMMVPVLKQIKVISKPGRRQWMSASNLALLTRQRVNFIPALEMGECLFIQTRKGVMEIREAIGLNLSGELLCRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLG5</accession>
    <name>M7NLG5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine incorporator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_03484</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875574.1">
        <property type="nucleotide sequence ID" value="XM_007877383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLG5"/>
    <dbReference type="STRING" id="1069680.M7NLG5"/>
    <dbReference type="GeneID" id="19897171"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03484"/>
    <dbReference type="eggNOG" id="KOG2592">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029574_2_0_1"/>
    <dbReference type="OMA" id="DKHCNPL"/>
    <dbReference type="OrthoDB" id="5963193at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="55316" checksum="59D6414D48F363A1" modified="2013-05-29" version="1">MWIILLIPLFLVGGIFMSSRWLISCFSHLSFSAFCKFSSFKSSNFLTRILYALLFILNCLFSWLMRSSWAIKKLEKLTPGIRMSCPEEKCYGVLSVHRINFSLGLLHLILAVLLMGIRSNKQKRACIQDGFWAFKIIGWSLIVMTAFLINDSFFIFWGNYFSFIGSIMFILFGLFLLIDFAYSWAEICYQKYEITQNNLWKTCLIGSTLFMYLGTIILMLVMYIFFAKPGCSLNQLIIFINFILLLVITTISIHPTVQDYNPQSGLAQSATVCLYTTYLTVSALSNEPVDSNNPLCNPMAHPSHTKTINIVFDAIFTFLAIAYNTSRAAVQSAFLYSKNDSLYYERLKEENDDDYPIIDESLHKMELRQKLLKTSVETGSLPASALNGSDDIFNDLSDQNYLEYNYSVFHFIFFLATCYTTCLLTGWGTLKTQGNKYDNNGPFLAIGYSYSIVWMKIFSSWICHGLYIWTCIAPVLFPDRFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>M7NM24</accession>
    <name>M7NM24_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair protein RAD51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_03414</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required both for recombination and for the repair of DNA damage caused by X-rays.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875500.1">
        <property type="nucleotide sequence ID" value="XM_007877309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NM24"/>
    <dbReference type="STRING" id="1069680.M7NM24"/>
    <dbReference type="GeneID" id="19897101"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03414"/>
    <dbReference type="eggNOG" id="KOG1433">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041732_0_0_1"/>
    <dbReference type="OMA" id="RAYNSNH"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000262">
        <property type="term" value="C:mitochondrial chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905334">
        <property type="term" value="F:Swi5-Sfr1 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030491">
        <property type="term" value="P:heteroduplex formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007533">
        <property type="term" value="P:mating type switching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000708">
        <property type="term" value="P:meiotic strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990426">
        <property type="term" value="P:mitotic recombination-dependent replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036298">
        <property type="term" value="P:recombinational interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120290">
        <property type="term" value="P:stalled replication fork localization to nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19513">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000008">
        <property type="entry name" value="DNA repair protein RAD51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000092">
        <property type="entry name" value="DNA repair protein Rad51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011941">
        <property type="entry name" value="DNA_recomb/repair_Rad51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02239">
        <property type="entry name" value="recomb_RAD51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF39">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="8">
        <location>
            <begin position="100"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="9">
        <location>
            <begin position="279"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="343" mass="37042" checksum="0588C9F94A60A201" modified="2013-05-29" version="1">MGLDEELAEETAQDMNEEDIICGPTPLSKLEGNGISASDIKKIIEAGYNTVEAIAYTPKRAILLIKGISEAKADKLISEASKLVPMGFTTATEFHQRRCELISITTGSKQLDTLLAGGIETGSITEIFGEFRTGKSQICHTLAVTCQLPIDMGGGEGKCLYIDTEGTFRPTRLLAVADRYGLNGEEVLDNVAYARAYNADHQLQLLGQAANMMAESRFSLLIVDSATSLYRTDFAGRGELSARQMHLAKFLRTLQRLADEYGIAVVITNQVVAQVDGNASMFNPDPKKPIGGNIIAHSSTTRLSLRKGRGEQRICKIYDSPCLAEADAVFAITNGGVDDPVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMH5</accession>
    <name>M7NMH5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_02052</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874034.1">
        <property type="nucleotide sequence ID" value="XM_007875843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMH5"/>
    <dbReference type="STRING" id="1069680.M7NMH5"/>
    <dbReference type="GeneID" id="19895746"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02052"/>
    <dbReference type="eggNOG" id="KOG4505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008635_5_0_1"/>
    <dbReference type="OMA" id="QSWAHES"/>
    <dbReference type="OrthoDB" id="5327978at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF4">
        <property type="entry name" value="NA(+)_H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="26"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR09873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="382" mass="42908" checksum="D22501A1DB3FD142" modified="2013-05-29" version="1">MVWNHVDISKPHIAYAIFGCFTSLFMLVSLFIKQRLYIGKAMVATIVGIIFGPYYINIFDPDYNILEFSRIVLIVQVFAVGVEFSKGYVLKHWKSLVMLLCPVMIFGWVVMSVIVYLLVSNLVFIEALILGACVTATNPVLVSSIVGKSEFSKKIPEYIRNILSCESGCNDGFVLPFLFIGLQLLVDSFRLKTIGKFLHIKILYEVVFGCILGSFIGFSAGAVFSWDDWFSKKTEESHVSNVIYLLLNFAFSVYWRAIILCKQYNMPELGVTPWRLLIVAICPLIPDIHTWREAFFCGHFGPMGVGAIFVSVLAPIKLETKIDEPSESVLANPIISYYKLILMIWPITSFLILSSIIVHGSSVAISVYGKHLNLFSFTPTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMH6</accession>
    <name>M7NMH6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="8">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_03161</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875224.1">
        <property type="nucleotide sequence ID" value="XM_007877033.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMH6"/>
    <dbReference type="STRING" id="1069680.M7NMH6"/>
    <dbReference type="GeneID" id="19896848"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03161"/>
    <dbReference type="eggNOG" id="KOG2315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013809_0_1_1"/>
    <dbReference type="OMA" id="RCCAYSP"/>
    <dbReference type="OrthoDB" id="2194683at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000596">
        <property type="entry name" value="Eukaryotic translation initiation factor 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="10">
        <location>
            <begin position="208"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="477"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR08321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="605" mass="68234" checksum="7642552D1FC0B1B1" modified="2013-05-29" version="1">MVFTQFACRTAQYISLTIGHPLYTPLPGFDRPEKNTVSCCYGQDGRFFAWSSLQDVKIIDTSTGELVRILEIPKVCEIKLSPKSNFIVTWERPSKAEDGSANKNLKIWKINTGQKLCSFVQKSQIWNLQYTTDGKLCARKVTNEIQFFESANMEKGPIYRLHANGVSSFSLSPGRNNVIAVFIPEMKGTPATVSIYNIPTFSFVISQKAFYKADNVQMKWNKIGTTLIISTSTDVDKTNKNYYGETNMYILSAIRNYDSRINLDKEGPIHDITWSPNSREFGVVYGYMPSKTTIFDNQANIIYSLPLSPRNTILFSPHDRFVLVAGFGNLKGTIDIYDKEKEMKKITTIEASNSTVCEWSPDGRHILTGITSPRLRVDNGIKIWHYSGALMYSEEINELYEVFWQPQNPEIYPLRSSLSPVPKPHSSASLVANKTPLKSVGAYRPPHARSTATPKEYKREDEKIMIISSQEIKHKTTTDPFIPGANPSIQTQGSSKAALKNKKRRDAAKKAKESKVIDVQSTNGISSQSITSNLEPPHVIENSLDNENKKIRSLLKKLRAIEKLKTQQEKGNKLEDTQIEKIATEGRLRSELKALGWNDQCMSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMV0</accession>
    <name>M7NMV0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_03286</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875359.1">
        <property type="nucleotide sequence ID" value="XM_007877168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMV0"/>
    <dbReference type="STRING" id="1069680.M7NMV0"/>
    <dbReference type="GeneID" id="19896973"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03286"/>
    <dbReference type="eggNOG" id="KOG1756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CALESQH"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099115">
        <property type="term" value="C:chromosome, subtelomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140463">
        <property type="term" value="F:chromatin-protein adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045143">
        <property type="term" value="P:homologous chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000008">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="14"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="13">
        <location>
            <begin position="93"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR08456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="148" mass="15758" checksum="913161249B93A1EA" modified="2013-05-29" version="1">MSSGGKGGKAAANKSGQSRSSKAGLTFPVGRVHRLLRKGNYAQRVGAGAPVYLAAVLEYLAAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGHVTIAQGGVLPNIHSNLLPAKSKKLGKGSACVYEIIKIVNHYLASQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMW1</accession>
    <name>M7NMW1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aspartate aminotransferase</fullName>
            <ecNumber evidence="8">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_03044</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="8"/>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875099.1">
        <property type="nucleotide sequence ID" value="XM_007876908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMW1"/>
    <dbReference type="STRING" id="1069680.M7NMW1"/>
    <dbReference type="GeneID" id="19896731"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03044"/>
    <dbReference type="eggNOG" id="KOG1411">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032440_1_2_1"/>
    <dbReference type="OMA" id="VGACTIV"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006533">
        <property type="term" value="P:L-aspartate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000026">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF22">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="51"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="422" mass="47644" checksum="6AFCDEF737FFB251" modified="2013-05-29" version="1">MIYLQRNILGTFFSKFRGVALSSTWAHVEQGPRDPILGINEVFELDKSPLKVNLGVGSYRDDNEKPYVLPSVREAEKRILFADLNKEYAAITGVSSFVKYASRLVYGEDSKALKEGRISVVQSVSGTGALRLGGEFLSRFYLSKKIYLPSPTWGNHIPIFKDSGLEINYYRYFDKNTIGFDIEGALEDIRAAPKGSIILFHACAHNPTGVDPTQEQWHLISSAVKSRNHYVFFDMAYQGFASGDLLKDSYALRYFVEEGHSLCVSQSFAKNMGLYGERVGTFSIVCESSEEKERVESQLKILIRPLISNPPIHGARIAAEILGNDELYKQWLSELKGMANRIISSRKMIRKCLEEDFQSKHDWSHITSQIGMFCYTGLNPEQVKLLTDKYHIYLTNDGRISIAGISSNNVRYVSESIHNVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN78</accession>
    <name>M7NN78_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GTP-binding protein rhoA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_01418</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873357.1">
        <property type="nucleotide sequence ID" value="XM_007875166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN78"/>
    <dbReference type="STRING" id="1069680.M7NN78"/>
    <dbReference type="GeneID" id="19895115"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01418"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_21_2_1"/>
    <dbReference type="OMA" id="EVNHYIP"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032995">
        <property type="term" value="P:regulation of fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01870">
        <property type="entry name" value="RhoA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000329">
        <property type="entry name" value="GTP-binding protein rhoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR10143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="193" mass="21707" checksum="734F7749E1467E2A" modified="2013-05-29" version="1">MSLEYRRKLVIVGDGACGKTCLLIVFSKGTFPEVYVPTVFENYVADVEVDGKHVELALWDTAGQEDYDRLRPLSYPDSHVILICFAVDSPDSLDNVQEKWVPEVLHFCSTLPVLLVACKKDLRHDMKTIEELRKTSQRPVTTEEGRAVSARIGAVDYHECSAKTNEGVREVFESATRAAMLTKQKKTKKCIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>M7NND1</accession>
    <name>M7NND1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histone acetyltransferase ESA1</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Histone acetyltransferase esa1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 20">protein 2-hydroxyisobutyryltransferase ESA1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 21">protein acetyltransferase ESA1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 22">protein crotonyltransferase ESA1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">PNEG_02912</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2E)-butenoyl-CoA + L-lysyl-[protein] = N(6)-(2E)-butenoyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53908"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:137954"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:53909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:131780"/>
            <dbReference type="ChEBI" id="CHEBI:144968"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:24181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:45949"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874952.1">
        <property type="nucleotide sequence ID" value="XM_007876761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NND1"/>
    <dbReference type="STRING" id="1069680.M7NND1"/>
    <dbReference type="GeneID" id="19896599"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02912"/>
    <dbReference type="eggNOG" id="KOG2747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011815_2_0_1"/>
    <dbReference type="OMA" id="DSPEGNN"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044016">
        <property type="term" value="F:histone H3K4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106226">
        <property type="term" value="F:peptide 2-hydroxyisobutyryltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140065">
        <property type="term" value="F:peptide butyryltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140064">
        <property type="term" value="F:peptide crotonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140861">
        <property type="term" value="P:DNA repair-dependent chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031453">
        <property type="term" value="P:positive regulation of heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000526">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000002">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF218">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE ESA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="24">
        <location>
            <begin position="201"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="23">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00074445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00075313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00076782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00077673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EMR08737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="485" mass="56959" checksum="3342E8C89DC25862" modified="2013-05-29" version="1">MSSEVSANISQIEDLKSQKLSMGCKIFVRKDKSFQKAEILSLQTRKNQPYFYVHYQGFNKRLDEWVSLSRIDFSKEIEFPKVDKAKKISKSNIQKTDDTETKIEDRTSKRHRICREEVSLDASTTGLKEIKEKDKTSTLKPKNDNQEGCYAQEEKEDIMLDIVEGDQMNCINKGQEKCSKTNEIEKLRTSGSMAQNIHEISRVKNLTMIQIGRHEIEPWYFSPYPIELTELDLIYICEFCFSYFGSKKQYERHRMKCTLQHPPGNEIYRDEHISFFEIDGRKQHTWCRNLCLLSKCFLDHKTLYYDVDPFLFYCMTTRDEYGCHLIGYFSKEKDSSENYNVACILTLPQYQRLGYGRLLIEFSYELSKKEGKLGSPEKPLSDLGLLSYRAFWADVVIELLMNTRVEVTIDEIANKTSMTSQDVLHTIQNLSLLKYYKGQHIICISEAIEQQYEKYKTKQRRKIDPNGLAHWKPPVFNSTQLRFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NND3</accession>
    <name>M7NND3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">20S-pre-rRNA D-site endonuclease NOB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01476</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NOB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873415.1">
        <property type="nucleotide sequence ID" value="XM_007875224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NND3"/>
    <dbReference type="STRING" id="1069680.M7NND3"/>
    <dbReference type="GeneID" id="19895172"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01476"/>
    <dbReference type="eggNOG" id="KOG2463">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024666_2_0_1"/>
    <dbReference type="OMA" id="DYAMQNT"/>
    <dbReference type="OrthoDB" id="446759at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09876">
        <property type="entry name" value="PIN_Nob1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000020">
        <property type="entry name" value="20S-pre-rRNA D-site endonuclease NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.10">
        <property type="entry name" value="Nin one binding (NOB1), Zn-ribbon-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039907">
        <property type="entry name" value="NOB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017117">
        <property type="entry name" value="Nob1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036283">
        <property type="entry name" value="NOB1_Zf-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014881">
        <property type="entry name" value="NOB1_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08772">
        <property type="entry name" value="Zn_ribbon_NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037125">
        <property type="entry name" value="D-site_20S_pre-rRNA_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144206">
        <property type="entry name" value="NOB1 zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ribonuclease PIN" evidence="10">
        <location>
            <begin position="14"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Nin one binding (NOB1) Zn-ribbon-like" evidence="9">
        <location>
            <begin position="243"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037125-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR10203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="385" mass="44294" checksum="DA8EBB414BFF2FCE" modified="2013-05-29" version="1">MTSTDKSSYFIGALVLDSSCFISFFKLSIINKASSFYTVPNVLTEIKDKSSCQTLSLWKEKIVIRTPKPLYIEKIITFSKKTGDYEILSITDIHLLALTYELESEMNDDSFQSYKELYQSKIDESPKKDDIDTLINENDLSNISTLKDSFEEKHQDKNLTNNVHQLVNDLENINFKEIDDDDSGWITPSNIHYHKLLNERSNMIPMKTTKYIKVACVTSDFAIQNILLQMNLNLVSPETGLKIKAVKSWVLRCHACFKIVKDMSKKFCPGCGGNTLLRTSCSIDSNGKFRIYLKRHMQWNNRGTIYPIPKPRHGSASGKGYKPIILREDQKEYQKALKYQKRKKEINLLDPDKLPDILTGKRNTSCYNVVIGMGKRNPNEKRKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNH4</accession>
    <name>M7NNH4_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PNEG_02952</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP = N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hydrogencarbonate + acetyl-CoA + ATP = malonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11308"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874997.1">
        <property type="nucleotide sequence ID" value="XM_007876806.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NNH4"/>
    <dbReference type="GeneID" id="19896639"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02952"/>
    <dbReference type="eggNOG" id="KOG0368">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_5_2_1"/>
    <dbReference type="OMA" id="PTPKGHC"/>
    <dbReference type="OrthoDB" id="14612at2759"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101026">
        <property type="term" value="P:mitotic nuclear membrane biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.460.10:FF:000001">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000010">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.460.10">
        <property type="entry name" value="Biotin dependent carboxylase carboxyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1770.10">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049074">
        <property type="entry name" value="ACCA_BT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013537">
        <property type="entry name" value="AcCoA_COase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08326">
        <property type="entry name" value="ACC_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21385">
        <property type="entry name" value="ACCA_BT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0092">Biotin</keyword>
    <keyword evidence="9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="17">
        <location>
            <begin position="1"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="16">
        <location>
            <begin position="115"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="15">
        <location>
            <begin position="598"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="18">
        <location>
            <begin position="1419"/>
            <end position="1757"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="19">
        <location>
            <begin position="1761"/>
            <end position="2075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMR08782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="2178" mass="248103" checksum="0BF9AEC9A3C23B33" modified="2013-05-29" version="1">MATPEDLKVNADYIKMAEQYVEVPGGSNNNNYANVELIVDIAERMGVHAVWAGWGHASENPRLPEMLSQSKNKIVFIGPSASSMRSLGDKISSIIIAQSANIPCMLWSGSNLKKVDIDKNCGLISIEDSVYHDACINTPEKGLEKALEIGFPIIIKASRGGGGKGIRKVEDKSEFKSSFLQVMAEVPGSPIFIMKLAENARHLEVQILADQYGNIISLFGRDCSVQRRHQKIIEEAPVTIAKPDTFSSMEKAAIALGKIVGYVSAGTVEYLYSHTDDKFYFLELNPRLQVEHPTTEMITGVNLPAAQLQIAMGLSLHKIKDIRLFYGLDPWTTTEIDFHFSKTKSLKTQRRPQPKGHTTACRITSEDPGEGFKPSSGMMHELIFRSSSNAWGYFSVAAPGGIHNYSDSQFGHIFAFGENRAESRKHMVIALKELSIRGDFRTTVEYLIKLLETYDFEQNTITTEWLDTLILQKLTLERPDKMVAIVCGAVIKAYVANKERILEYKTCLEKGQVLSRETLKTVFSVDFIYLKEKFKFTVTRSSSDSYNLFINGSKCTVETRRLSGGGLLILLGGKSHTVYWSDNKTNTTMSINGKTCILEQENDPTQLRSPSPGKLVKYLVGNGEHVKKGQVFAEIEVMKMYLSLTVAEDGIVQLIKQPGATLETGDILGILTMDDPSRIKHAKPFEDSLPSWGLPQVIGNKPPQRFVQLIRILKNILQGYDNQLLIISTLKELIEVLEDPELPYGEWHFQFSALSSNIPEKLGEHLLDIVKKNYSKHKEFPGKKILRKFDLFIRRNILSDDIEILKMKLNSLFQIALKYKDGMKVHKYLVLSNLLEEYWKIESLFNLQNIREEDVILRLRDENKDNIDKVLEIVLSHSKVNAKNDLISAILDIIKTCPSEDISKYLGPSLRKLIDLESRDTVKVSLKAREILIQCSLPSFGERISQMKQILQSSIEEKLNNNQLKYRTPVLDILRELIDSKYAVFDVLTFFFAHKNPWISLAALEVYVRRAYRAYSLLSLEYHVESDGPFMISWKFQLRSSTSQGINACTAAQLPSISTEFTENRKLKRVASISDMSLLISDSKPPRAGVIVPTETLGQINDQLPRALKKLPIDKENTDEYEQDIEIDSPHELKNSTSKKQLIHVLNVLIRNIENLDDKAIIDHLCPIVKDHTPLLLIHKVRRITFVCGRQNESSYPLYYTFRKLEGLSNEIANVYAEDKSIRHIEPALAFQLELGRLSNFHIEPVFTRNRNIHIYRAVAKESPGDKRFFTRALVRPGKLTNEIPTSEYLISETNHLIGDILDALEIIGIEYTDLNHIFINFVPIFNLAPDEVEPTLGGFIERFGRRLWRLRITSAEIRIICTDSLTGLASPLRIIISNVSGFVVCFELYTEVKTSKGHHIFQSIGPPGSMHLRSITTPYATKEWLQPKRYKAHLIGTTYVYDFPEIFRQAVRISWQKYIQINNNCKIPDDILKVKELVMDDKFQLQEVIREPGTNSIGMVAWLVTAKTPEYPQGRQFILIANDITFRTGTFGPDEDQYFFKATLLARQLRIPRIYLSANSGARIGLSEELISLFSVAWNDPKNPEKGFKYLYFTPEIYKQFEENNREDFISEKIIENGEERYKITAIIGSEEVLGVECLRGAGLIAGETSRTYEDIFTITLVTCRSVGIGAYLVRLGQRTIQVEGHPIILTGISTINKLLGCEVYSSNLQLGGTQIMYKNGISHLTAKNDFNGISKIMNWLSFVPDKKDNPVPVLPSLDSWDRDVEYVPPKSAYDVRWLIEGKEDDNCFLSGLFDRKSFHETLSGWAKTVVIGRARLGGIPIGIIAVEARSIENTLPADPANPESYEQNIIEAGNVWYPNSAFKTAQAINDFNYGEQLPLFILANWRGFSGGQRDMFNEVLKYGSYIVDSLSKYKQPIFIYIPPYCELRGGSWVVIDPTVNEDMMEMYADEKSRAGILEPEGLVEIKFRKEKLLGCMSRLDPIYASLKKQLQNPNLSQDQLTEIKTKIDEREKLLLPIYHQISIEYADLHDLPIRMERKGAIRQCLQWSQSRRFFYWRLRRRLNEHYAIQKIKKVNKKLSFRQSVEILKKWISQLYNNDLDWDNNDREIVLLLEKNKEHIESLIKEFEKTTISDEIVDMAKLNKASVLNGFSRVLEEMSDQETNEIIKILSQRKIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNT4</accession>
    <name>M7NNT4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">F-actin-capping protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02928</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the F-actin-capping protein alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874971.1">
        <property type="nucleotide sequence ID" value="XM_007876780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNT4"/>
    <dbReference type="STRING" id="1069680.M7NNT4"/>
    <dbReference type="GeneID" id="19896615"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02928"/>
    <dbReference type="eggNOG" id="KOG0836">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045161_3_0_1"/>
    <dbReference type="OMA" id="VACIEDH"/>
    <dbReference type="OrthoDB" id="340550at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904600">
        <property type="term" value="P:mating projection actin fusion focus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902404">
        <property type="term" value="P:mitotic actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.60">
        <property type="entry name" value="F-actin capping protein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002189">
        <property type="entry name" value="CapZ_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042489">
        <property type="entry name" value="CapZ_alpha_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017865">
        <property type="entry name" value="F-actin_cap_asu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01267">
        <property type="entry name" value="F-actin_cap_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00191">
        <property type="entry name" value="FACTINCAPA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00748">
        <property type="entry name" value="F_ACTIN_CAPPING_A_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0117">Actin capping</keyword>
    <keyword evidence="4 5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="269" mass="31348" checksum="D4AD480A4D1052E9" modified="2013-05-29" version="1">MTISIYDLIEDSPPGEVNDVFNDIRILVNNDKSFFEEIVPCLARYNKEQFTNIRIPGSENETIISQYNCEDGRFFDPISKKSFLFDHLNLQVSDIQPYEIDEKISEKINDLLKPLLIYLSEHFPSSVNYGIFPGKNDTYYILIVGNKYNPVNFWNGRWRSFYQFSESSLVITATLLIDVHYYEDGNVRLTTNHNFSFEAKSANSSDIIAAIAEEEKKYQEELNMTFHGLNDHDFKSLRRQLPMTKQKINWENISSLKIGKDMAGRNQTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNU5</accession>
    <name>M7NNU5_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat cdt2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873577.1">
        <property type="nucleotide sequence ID" value="XM_007875386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNU5"/>
    <dbReference type="STRING" id="1069680.M7NNU5"/>
    <dbReference type="GeneID" id="19895314"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01620"/>
    <dbReference type="eggNOG" id="KOG0321">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038595_0_0_1"/>
    <dbReference type="OMA" id="DSRVHTY"/>
    <dbReference type="OrthoDB" id="2096344at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000779">
        <property type="term" value="P:regulation of double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051865">
        <property type="entry name" value="WD-repeat_CDT2_adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852:SF0">
        <property type="entry name" value="DENTICLELESS PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852">
        <property type="entry name" value="LETHAL 2 DENTICLELESS PROTEIN RETINOIC ACID-REGULATED NUCLEAR MATRIX-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="108"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="421" mass="47695" checksum="3E90B8B0853D5D4B" modified="2013-05-29" version="1">MKLTRNDILRGQSEGCCLYKFPLSTLERNLSGNNIYDLSISIRKKLMRSFYSRPFDRFLIENEDTLDVPFAVSFSNNHPILGVSDESGFIHFIDTVKKEKQIDEFLKVKCHDNAIFDISWSYDDKLLASSSGDQTARVLDISNQKFVAILSKCTSSTLKQVSFQKDDPNILATCSRNGKILIWDLRSHGVESSAQMPVVSILNAHGKIKHHSRRSKLMPMSNSITSIQWLHRKNLLASACDANSFINIWDIRFYSQKFIKLYESKPAVSIKNKRDHGITSLAMPSFGSTFYGLSRDNYIYAYSSTHPEEPIGSFTHPQLMVKSFFVKISCSKDGQFLGCGSSNSQVIIADTASMTENKNIGVALISGCEKEITGISWSYDDCIASISDDTSCRIWRQGQNNEAEDIRSWNEGKRWEWGWVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP30</accession>
    <name>M7NP30_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02642</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874661.1">
        <property type="nucleotide sequence ID" value="XM_007876470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP30"/>
    <dbReference type="STRING" id="1069680.M7NP30"/>
    <dbReference type="GeneID" id="19896333"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02642"/>
    <dbReference type="eggNOG" id="KOG4373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_921730_0_0_1"/>
    <dbReference type="OMA" id="RMNFCAK"/>
    <dbReference type="OrthoDB" id="1920326at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06141">
        <property type="entry name" value="WRN_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051132">
        <property type="entry name" value="3-5_Exonuclease_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620">
        <property type="entry name" value="3-5 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620:SF104">
        <property type="entry name" value="EXONUCLEASE 3'-5' DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="3">
        <location>
            <begin position="88"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="302" mass="34879" checksum="9FB5B36FA0A96AF9" modified="2013-05-29" version="1">MQKLLNIVCFYRNFSVRSERFAFFLKKKVIYSFIKMSVQRLSSTCSSEEKIDVFPNNKDSKQIVEPKKYRYWSYLDIKNSRGKPQAKIHYILKLSGVQNAISLLKGPYLGFDMEWKPHGDSKIAIIQLSDANSIVLFHLSQMDLEGTFPGPLKDLLENPYFIKCGVGVRNDGYKLYKDFGIIGSGFLELSQLAITVDKDKWDPSLRLIGLTRLAEEYLGKPLFKGSVRYSNWEDELIFKQMHYAATDCFAGLKIFERLNDLRQSSDVPLNIPELIDMHLDPSVIDDIQKKEKNILLQLKKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP31</accession>
    <name>M7NP31_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Branchpoint-bridging protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PNEG_01182</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the BBP/SF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873097.1">
        <property type="nucleotide sequence ID" value="XM_007874906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP31"/>
    <dbReference type="STRING" id="1069680.M7NP31"/>
    <dbReference type="GeneID" id="19894879"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01182"/>
    <dbReference type="eggNOG" id="KOG0119">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016864_3_0_1"/>
    <dbReference type="OMA" id="INLICRI"/>
    <dbReference type="OrthoDB" id="6777263at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045131">
        <property type="term" value="F:pre-mRNA branch point binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02395">
        <property type="entry name" value="KH-I_BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000030">
        <property type="entry name" value="Branchpoint-bridging protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000024">
        <property type="entry name" value="Branchpoint-bridging protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032570">
        <property type="entry name" value="SF1-HH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047086">
        <property type="entry name" value="SF1-HH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF45">
        <property type="entry name" value="SPLICING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16275">
        <property type="entry name" value="SF1-HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 15" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11 15" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 15" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 13 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="18">
        <location>
            <begin position="313"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="18">
        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="458"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMR10468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="525" mass="57380" checksum="A6FA95FDF0D613FC" modified="2013-05-29" version="1">MHCETTGTNNVPLGSRRRFGQEEPGTEAEHDGKQHGNRYIPPLPSDSSAPLPPGVDEPRGYRTGGPRVRKRKNRWGTGGAEGNKALGLIGLPTAITSNMTNEQLEAYALHMRLEEIGQKLRIGDVVPRDGERSPSPPPQYDNFGRRTNTREIRYRKRLEDERHRLINKAMCTIPDFKPPVDYRRPTKTQDKIYVPVNDYPEINFIGLLIGPRGNTLKKMEAESGAKIAIRGKGSVKEGKGRNDPSANSNLEEDLHCLVMADTEDKVRHAIKLIEDIIETAASVPEEQNDLKRQQLRDLATLNGTLRDDENQVCQNCGNVGHRRFDCPERQNFTANVVCRICGNAGHMSRDCIMRNDPEVLRQLNNGNDAADREYENLMQELGQGRNEAGRIEGASTAPWASLMGSSAAPPWAKALPDTHNVSVPPPWVQSNVSIPPPPGVSQGAHGVTSYGVPGTAPPTLPMYGPPPGMSTYGSSGSLYSSMPPGLASSNPPPLPNAPFQPLSSSNGSYGIPPPPPSDYKHPLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP39</accession>
    <name>M7NP39_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01191</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat mio family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873107.1">
        <property type="nucleotide sequence ID" value="XM_007874916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP39"/>
    <dbReference type="STRING" id="1069680.M7NP39"/>
    <dbReference type="GeneID" id="19894888"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01191"/>
    <dbReference type="eggNOG" id="KOG1008">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005843_0_0_1"/>
    <dbReference type="OMA" id="YEPTGHA"/>
    <dbReference type="OrthoDB" id="341486at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16691">
        <property type="entry name" value="mRING-H2-C3H3C2_Mio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037593">
        <property type="entry name" value="MIOS/Sea4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049092">
        <property type="entry name" value="MIOS_a-sol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031488">
        <property type="entry name" value="Zn_ribbon_mio"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453:SF9">
        <property type="entry name" value="GATOR COMPLEX PROTEIN MIOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453">
        <property type="entry name" value="WD40 DOMAIN-CONTAINING PROTEIN MIO FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21719">
        <property type="entry name" value="MIOS_a-sol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21720">
        <property type="entry name" value="MIOS_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17034">
        <property type="entry name" value="zinc_ribbon_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="MIOS-like alpha-solenoid" evidence="5">
        <location>
            <begin position="452"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="GATOR2 complex protein MIO zinc-ribbon like" evidence="4">
        <location>
            <begin position="806"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="930" mass="106623" checksum="71D2C4712DE9B8C9" modified="2013-05-29" version="1">MGEKSTIKRIPSLGYDKESHFVCTFPHKNEVHLYTVNNQNNCYSLTCLKSKIPFIKCIDCSPSQKNMVAIGKTTGDALLLCLDNEKPPIQFPIKQQRACNAIALNALEDLAVGLEKMKNEPCIMIWDIRQDVELNNKISPVQQLAISEPVFSLSYFPDSPKQLVSGINLRSIKIFDLREKSSTSMITLYSTRFIHSITIDPKNPNYFASISDEGLISIWDRRKSSNGEPCLLLNRGANQFSRIIDLKFTGTKPGQLSGLSKEGIIKLWDINYNHDDYNEFILFNDKKTSEISEPSTLIKSNPLSLMYLREASTKCSEKIISFDYIPSEPYKNYQFYYIKSDNKIGRLKIRSLCDTVSINSLNDIVISEKINLHLSQKNNDTILAKNKIENEDNKSQVSDSLSINIEENLSNNQIEESETYPLFSNSKIDQEYDTEYSFNIQDILENDISYLMYKRAKDGYGMEPAKNKKILENTYLLDLWTWINNAENLALENKMISSDFDLSYQGVYNIWHGIPHPNSLKKYDENNENSFKNSYTIAVKEINNKLKNNVFTSVTSKIEIRKLALVSCGWNISRENLDDEIKQLEEKGLCSKAACRALFHDNFNRTVQVLSKGTEKHRLMSTAIAGFSAKNNTNNTMWKEMCRKMSTELDDPYLRAIFAYVSNGDWRDVLDEQGLPLKERIGVGLRFLDDDDFSFYLNDIVKNVINTGDLEGIILTGISVNTVNLIETYLNRTSDIQTAALVSSFCVPKFIDQRILTWIEDYRQLLNRYSLFYSRAKFDVLRKKYSRNSEEFLILEKPPQQVYLRCNFCNKSITHKPITSKHHTNIQNSNIPSTGNIQKSTLCPACSKPLPRCAVCLLSLGTSCNLTNKNIKDPQDFEKLFEKWFNFCLSCHHVSHNDHATKWFETHSICPVADCNCLCREKDRIPKASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP48</accession>
    <name>M7NP48_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_02814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874848.1">
        <property type="nucleotide sequence ID" value="XM_007876657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP48"/>
    <dbReference type="GeneID" id="19896503"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02814"/>
    <dbReference type="HOGENOM" id="CLU_877506_0_0_1"/>
    <dbReference type="OrthoDB" id="5399567at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR09042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="317" mass="36239" checksum="39F636993065B8D6" modified="2013-05-29" version="1">MEGPSFNSLFNTCDQKEMTVLKTKEKNVCNKSIESGKIYELQDKLLISKKEQNLPDSMTITKLPKEMKQNSINLTGFVSSIINSVKGAWIKAKKDYKKSLRKQTKLRHLKKYSNSDFLKVKKTALKARKRLKHAEIDKENVSCIYTEPITFQSCVEKSPVCELKSPDIPMSIDINGPNLDNSLTISDSMDKDLKGPELVKTNDLYCSFESLKEEFEKTKKRLQIFEQKYGPFEQLFPNVEHKETLEIFNTPKTQNQTMVDLASSIPSISKDISTSIDNLSNFNQTKNYQLLDEDPSLEILSPVILQNKNVSYNTEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPA3</accession>
    <name>M7NPA3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PNEG_02437</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874444.1">
        <property type="nucleotide sequence ID" value="XM_007876253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPA3"/>
    <dbReference type="STRING" id="1069680.M7NPA3"/>
    <dbReference type="GeneID" id="19896130"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02437"/>
    <dbReference type="eggNOG" id="KOG1729">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069851_0_0_1"/>
    <dbReference type="OMA" id="NFCPLHD"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16489">
        <property type="entry name" value="mRING-CH-C4HC2H_ZNRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051878">
        <property type="entry name" value="ZNRF_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNRF1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15" id="KW-0458">Lysosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="20">
        <location>
            <begin position="28"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="181"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EMR09092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="228" mass="26441" checksum="9E7F3CFFD83B291B" modified="2013-05-29" version="1">MNPLSCQSSNIKQRSNSFSNSSKIWQPDSDVLLCPFCKRAFSFFHRRHHCRKCGCVVCSSCSSNNWDFSRSFDLKKNSNKQCDSKVLRVCDKCFMQLFEEQSQKKTESHSLIQKTRINNDEMMECPVCLESFSMIPTLSEREIHIDKCLKNNHYTSESTLNKRRFLSYVLPQSSSLVGTECIICFEEMLPGEKIARLECLCNYHVICIRQWISITTGRGCCPIHMLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPL3</accession>
    <name>M7NPL3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC1 atypical kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01348</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873278.1">
        <property type="nucleotide sequence ID" value="XM_007875087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPL3"/>
    <dbReference type="STRING" id="1069680.M7NPL3"/>
    <dbReference type="GeneID" id="19895045"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01348"/>
    <dbReference type="eggNOG" id="KOG1234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_9_2_1"/>
    <dbReference type="OMA" id="HGMFNAD"/>
    <dbReference type="OrthoDB" id="201153at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF3">
        <property type="entry name" value="COENZYME Q8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="6">
        <location>
            <begin position="178"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="393" mass="46012" checksum="C8C419D30064B919" modified="2013-05-29" version="1">MRTSSLLNQYFYIHRTNRNIFIVFKRFYIFYSNRDVIIGRKNKEIKACLTHKLKKIQITCFLRKYSKKSNKKNENNESLNYESTKELPSMQESTVPTSQIERLYHFGSLFVGLGIGALQESFQRLSSKRENTSLIMNKSNINRLVAKLSKMRGAALKVGQIISFQEMLPTTLHEILVKLQNHANCMPMNQMEEIMTKEFTKDWRNLFSKFNETPIAAASIGQVHSAVLKSSYLPVAVKIQYPGIKESIDSDLSNLEILLIASGFFPKGLFLDKIIDFARKELILECDYEREANCMKHFQELFKNDETFLIPKVIPEITSKHVLTMEYLSGKSLAKVNEVDQKTRNWLGTSLFKLCLREIIEFKYMQTDPNWSNFLFDENSRKEFLIYNYWKHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPN8</accession>
    <name>M7NPN8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">T-complex protein 1 subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_01372</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873303.1">
        <property type="nucleotide sequence ID" value="XM_007875112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPN8"/>
    <dbReference type="STRING" id="1069680.M7NPN8"/>
    <dbReference type="GeneID" id="19895069"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01372"/>
    <dbReference type="eggNOG" id="KOG0364">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CGGSTIR"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03337">
        <property type="entry name" value="TCP1_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000073">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000085">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000005">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012719">
        <property type="entry name" value="Chap_CCT_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02344">
        <property type="entry name" value="chap_CCT_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR10673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="549" mass="61410" checksum="CDE47E91D6C7EB0F" modified="2013-05-29" version="1">MRNPVILMDMNAKRQLGRKAQVSNIHSAKTVADIIRTCLGPNAMLKMILDQMGGVLLTNDGHAILREIEVAHPAAKSMIELSRTQDEEVGDGTTTVIVLAGECLIHSLLHLERNIHPVIVISAFKHALADALSIIEEISQKVNTKSDKEMNELINISIGTKFINRWSDLMCKLALKAVRIVENNVDGKHEIDIKRYARVEKIPGGEINQSVVLDGIMLNKDVTHPKMRRKIENPRIVLLDCPLEYKKGESQTNIEITKDEDWNRILQIEEEQVRQMCEAILALKPDIVFTEKGISDLAQHFFLKANITAIRRVRKSDNNRIARAVGATIVNRVEDLRENDVGKDCGYFEISKIGDEYYTFLTKCKNPKACTILLRGPSKDIINEIERNLQDAMCVARNVLFYPKLSPGGGATEMAISVRLSEKAKSIEGIIQWPYKSIADAMEVIPRTLVQNCGANPVKVLTELRAKHVNGQHSWGIDGETGKVVDMRLYGIWEPQAVKAQSIKTAIESACHLLRVDDIVSGIKKPKEKGSSVVETQNISEKDIENQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPR6</accession>
    <name>M7NPR6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gem-associated protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gemin-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872758.1">
        <property type="nucleotide sequence ID" value="XM_007874567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPR6"/>
    <dbReference type="STRING" id="1069680.M7NPR6"/>
    <dbReference type="GeneID" id="19894547"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00849"/>
    <dbReference type="eggNOG" id="ENOG502SCAA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1185614_0_0_1"/>
    <dbReference type="OMA" id="DIFENCA"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035426">
        <property type="entry name" value="Gemin2/Brr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794:SF0">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794">
        <property type="entry name" value="GEMIN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04938">
        <property type="entry name" value="SIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="28669" checksum="53F8514C226D0ED7" modified="2013-05-29" version="1">MRKKTKKMIRNETKMIISGPIDVETNQRGVFPELIELNESSESDDSLPLDGVSYLKKVRIEAKHRPIIKAVEAPPTAMTITQISEPKINNKAEEIYSSVWEEKFLKSFIKLRRNLNLQTKSVILRPLPKDKIEWRRLILEELEPPSISLLNSINQCTALNLLKWNTEWFSYNSPEQQIMWIFFLLIKIDMVMTSDELSILRELCKKCLFLRNSKKNLPLHIQSNIDMVISIVGNIFGQKDLLLNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPX0</accession>
    <name>M7NPX0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_02252</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874241.1">
        <property type="nucleotide sequence ID" value="XM_007876050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPX0"/>
    <dbReference type="STRING" id="1069680.M7NPX0"/>
    <dbReference type="GeneID" id="19895945"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02252"/>
    <dbReference type="eggNOG" id="KOG1332">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032441_0_1_1"/>
    <dbReference type="OMA" id="IWKEEGD"/>
    <dbReference type="OrthoDB" id="364224at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061700">
        <property type="term" value="C:GATOR2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051664">
        <property type="term" value="P:nuclear pore localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902953">
        <property type="term" value="P:positive regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070863">
        <property type="term" value="P:positive regulation of protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000017">
        <property type="entry name" value="SEC13 homolog (S. cerevisiae)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="52"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="207"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR09292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="304" mass="34441" checksum="18768F462AEE6066" modified="2013-05-29" version="1">MSNQRTLETQHEDMIHDAVLDYYGRRLATCSSDKSIRIFEIDGDQQRLVETLRGHDGPVWNVSWAHPKFGVILASGGYDGRVIIWKEINNLWSKLAEHTFHQASVNSVSWAPHELGAILACGSSDRRVSVLEFKDDGTWDTRTFPAHSVGCNAVSWSPCTPPASLIRTGKDQDLNFFKKIVTGGSDNLLKIWNFSNEQNNWVIEEVLEGHTDWVRDVDWAPNIGLPKSYIASASQDKTVIIWTKEGDGPWKKTYLSDEPFLDTVWRVNWSLLGNILAVSCGDNRIYLYKETLKGTFKQINEITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPX8</accession>
    <name>M7NPX8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02267</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874256.1">
        <property type="nucleotide sequence ID" value="XM_007876065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPX8"/>
    <dbReference type="STRING" id="1069680.M7NPX8"/>
    <dbReference type="GeneID" id="19895960"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02267"/>
    <dbReference type="eggNOG" id="KOG0350">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_15_3_1"/>
    <dbReference type="OMA" id="HEVKAFD"/>
    <dbReference type="OrthoDB" id="3370at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17956">
        <property type="entry name" value="DEADc_DDX51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="170"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="424"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="635" mass="73484" checksum="70F78B3E89D3BA5D" modified="2013-05-29" version="1">MLGYERYDPAANYPSKDARDSILSRINERFKRSPQEIQKNEERENKRKRKNDIENEDNKAFIPIFDVSDEKYGEIWHENDKNGSKTKDLSEEDLVEKDFDLKIDNNDYMDCLLDLLPKWLSTPTKIVSDLRLSLDDHSIHLDKEFKDRLRSRNYIELFPVQVETLKIILNDPYGVKGDFFISAATGSGKTLAYTIPVVQMLSKRKIVRLRCIVIVPTKELVYQIRECFEYCIGGSGLKIGISTGQRSFIYEQSKLVGDLDHCFSGGQSLVDILICTPGRLVDHIQHTPNFSLQHLKYLIIDEADRLLSQRFQNWIEILMNEIELSKSYKDSHYKTVEDLPDAVSDSLKLIFKDDLSMEKRPCNLQKFIFSATLTCNPEKIASLRLRNPQLILIQESKSNLDQCFFKTKAFLQNNDISTFFVPPTLIEYVILVESNAKPLYLYYLIKSREMEGVLCFTKSNESASRLCKLLNLIHENFISGPLNSITEKSDSKFISTSFDLVKLFGLFTSEVPKKQRNVALERFKNGDTKIFICSDLIARGIDLSQVFHVINYDIPQTSRQYIHRIGRTARAGKTGKAWTLYQKFESKKIHKILENVGRETKVIHEKMSAIIFTSEYTMAYKFALKKLKKYIKGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ09</accession>
    <name>M7NQ09_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED8</name>
        <name evidence="10" type="ORF">PNEG_02301</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874296.1">
        <property type="nucleotide sequence ID" value="XM_007876105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ09"/>
    <dbReference type="STRING" id="1069680.M7NQ09"/>
    <dbReference type="GeneID" id="19895994"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02301"/>
    <dbReference type="eggNOG" id="ENOG502S8U1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108151_0_0_1"/>
    <dbReference type="OMA" id="PQWYSLQ"/>
    <dbReference type="OrthoDB" id="5329317at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019364">
        <property type="entry name" value="Mediatior_Med8_fun/met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13074">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13074:SF9">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10232">
        <property type="entry name" value="Med8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR09347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="193" mass="22791" checksum="8EE2EC0537FC801B" modified="2013-05-29" version="1">MEFFPLNILESLRNRVLQLLHSFTHFLNIIDHSDALPSWKVLISNFNTLLSHVDSISFLLQESDILKETKVFPSSNFPVRQQEGLLTTLLRKKVAPETEEWEAEGRLLGTNAEESTSFYEWAKYIVMQEKEKRNWKGYYTREQELEISQNKTFNQEDTLEEIRKKRKLEETETKAKMNDVLLFMRTGKLEAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ60</accession>
    <name>M7NQ60_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00984</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872898.1">
        <property type="nucleotide sequence ID" value="XM_007874707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ60"/>
    <dbReference type="STRING" id="1069680.M7NQ60"/>
    <dbReference type="GeneID" id="19894682"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00984"/>
    <dbReference type="eggNOG" id="ENOG502QPWC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009666_1_1_1"/>
    <dbReference type="OMA" id="HHIAMMA"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900087">
        <property type="term" value="P:positive regulation of G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009303">
        <property type="term" value="P:rRNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000001">
        <property type="entry name" value="APSES transcription factor (MbpA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF3">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="433"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="530"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="725" mass="81300" checksum="4B0938EB7665EBAA" modified="2013-05-29" version="1">MNHDISSSEVYSAVYSGVPVYEMICQGISVMRRRSNSYLNATQILKVAGIDKGKRTKILEKEILVGEHEKVQGGYGKYQGTWIPFERGVEFCRQYGVEQMLWPILSLDLSVENQNNNTPTKEQALAFRRKHSLDSVENKKSNPLKIKPSYATYPSSSSVTNPNNPKVVPPKAGNYTSLEFHNNVPVYHSTAYPKNQVLTLNNSKINENIEESSEKHHGFFNKPSNCIIPPDIARREHPAFMDIYLQTNNKPFEPLDQKVAHNFHRSRNILTSIFLDNDIHNVPNVLINSSSDYALDIDVCIDELGHSALHWASALARLPLVAALVYKGSDPRRGNFSGETALIRAVLVTNNLDQSTFSELLEYIYPAIPLVDHQGRTVLHHIALTAGIKGRSAASRYYLETLLEWIVKNSEGEKNVLTLSSFVAKVVDAQDKNGDTALNIAARIGNKSIVQQLLDIGADATVPNRAGLRPLDFGITGEIPLSFQELRNQSPVIPATVVQKSQDIFESMKSMMTILDKEFYNEIHKKQALIDLAYAQLRDATRTLAELRKNLENSRAQASYLADIQQKCRNIERAINDETLYYYNYSDPSFKTNKEITDISSNIFNEKIDPDAPFAVDISFLDVNDQDSPLYISIPILRARISAYQKNAKALSSLATSLRGRSSELEDKCRRVVSLCIGVEESKVDSLLEGLLQAVESDDHQAVDMVRLSGFLKLINEDRHGTKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ64</accession>
    <name>M7NQ64_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">General transcription factor TFIIB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_00989</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872903.1">
        <property type="nucleotide sequence ID" value="XM_007874712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ64"/>
    <dbReference type="STRING" id="1069680.M7NQ64"/>
    <dbReference type="GeneID" id="19894687"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00989"/>
    <dbReference type="eggNOG" id="KOG1597">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043736_1_0_1"/>
    <dbReference type="OMA" id="DHDQRMK"/>
    <dbReference type="OrthoDB" id="25790at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001139">
        <property type="term" value="F:RNA polymerase II complex recruiting activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001113">
        <property type="term" value="P:transcription open complex formation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001174">
        <property type="term" value="P:transcriptional start site selection at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd20551">
        <property type="entry name" value="CYCLIN_TFIIB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20552">
        <property type="entry name" value="CYCLIN_TFIIB_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000008">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000141">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000036">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="13">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR10843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="338" mass="36637" checksum="B133EEE93A62B307" modified="2013-05-29" version="1">MQLASTNLYTINPGAINLNVRIICSDCKEDPPNLVEEFSSGDTVCGSCGLVVGDRIVDTRSEWRTFANDEGGDNQSRVGTSANPLLNGSQLDTIISTQDGGHGLSKTQGRSVAQKGEKNLVSAYREISAMCDAIHLPKSISDIAKQVFKKVDDSKALKGRSNESIISACIFIACRQGKAPRTFKEICALTNVPKKEIGRVFKSLQKMLTDDNLLSSNAGQGDDSYIPSSTSPKDLMIRFCNRLSLPTSVQIAASELANRASAEGTLAGRSPISIAASGIYMASYLFQHPKLPREIAEVVGVSDSTIRNAYKSLYLEREKLIDPKWLNGKSMDMILPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ79</accession>
    <name>M7NQ79_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine-rich transmembrane CYSTM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872923.1">
        <property type="nucleotide sequence ID" value="XM_007874732.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ79"/>
    <dbReference type="GeneID" id="19894707"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01009"/>
    <dbReference type="HOGENOM" id="CLU_2373668_0_0_1"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="10180" checksum="30BAA9DB4634E73F" modified="2013-05-29" version="1">MSAKDYYDAKDVNNQNYPPPPPQYPQQSYYPPSGAAPPPGAPPSQYPPGAYCNGYYSQPQPVYVQQQSSSNKAATGCLACLAACCACCMLEECLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQL3</accession>
    <name>M7NQL3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874340.1">
        <property type="nucleotide sequence ID" value="XM_007876149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQL3"/>
    <dbReference type="STRING" id="1069680.M7NQL3"/>
    <dbReference type="GeneID" id="19896030"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02337"/>
    <dbReference type="eggNOG" id="KOG2132">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016785_0_1_1"/>
    <dbReference type="OMA" id="VPDYCYI"/>
    <dbReference type="OrthoDB" id="47172at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000046">
        <property type="entry name" value="JmjC domain-containing protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF101">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="284"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="430" mass="50353" checksum="FEB27929283114F7" modified="2013-05-29" version="1">METRQKQYNILKQLEKRLFPDVFRPCGMAVDYLIRQSLKRLQVLQETPFTDVTQTELKNILDRVNDTLRLSTEKFYSYPFSKVPFAWKQLYAYASILKAIIQTEMHEETAEIIKTLDMALIMTNGADVKAFIMTLLALQEPKINADHQIQDFYVRKTEKHKKIQFPIRYAECPSLEAFHKDMFNIKQPLIIKNSINHWPALAQDGWAKIKTLLDKTHQGLRIVPVEIGKNYTSEDWGQRLMPFYEFLEKYILQKKNSSNEKNKEKEIGYLAQHDLFSQIPALREQIVIPDYCFLTPPPIPFHQQEYIKEMPTLDEPLLNVWFGGEGTVSPLHTDPYHNILSQVVGWKYVRLYAPEEREALYPRSIEGGIDMSNTSQVDLDNPDTEKFPKFLQAKYVESIIGPGDCLYIPVGWWHYVRSLSISFSVSFWWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQW8</accession>
    <name>M7NQW8_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_02094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874074.1">
        <property type="nucleotide sequence ID" value="XM_007875883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQW8"/>
    <dbReference type="GeneID" id="19895788"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02094"/>
    <dbReference type="HOGENOM" id="CLU_1704985_0_0_1"/>
    <dbReference type="OrthoDB" id="5299893at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR09506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="154" mass="17116" checksum="2488FC952DE7C04C" modified="2013-05-29" version="1">MGNCWSLCQGNRRHQSTLHERASLLHSKHVSSSCPCRSEQTLSSADLALEEQEVLSKIVLNASERLINMYALTSEKPSLPDTSGLKMDDLKRLEQLTAPEIPIYNGLISIGMTRKELELMDGVAKLVKEAIKEIKTIKNVGQVIVKLDESRKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NR58</accession>
    <name>M7NR58_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcriptional coactivator p15 (PC4) C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01922</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transcriptional coactivator PC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873898.1">
        <property type="nucleotide sequence ID" value="XM_007875707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NR58"/>
    <dbReference type="STRING" id="1069680.M7NR58"/>
    <dbReference type="GeneID" id="19895616"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01922"/>
    <dbReference type="eggNOG" id="KOG2712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104273_1_2_1"/>
    <dbReference type="OMA" id="EYYEETA"/>
    <dbReference type="OrthoDB" id="2505440at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.10">
        <property type="entry name" value="Transcriptional Coactivator Pc4, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003173">
        <property type="entry name" value="PC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009044">
        <property type="entry name" value="ssDNA-bd_transcriptional_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045125">
        <property type="entry name" value="Sub1/Tcp4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13215">
        <property type="entry name" value="RNA POLYMERASE II TRANSCRIPTIONAL COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02229">
        <property type="entry name" value="PC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54447">
        <property type="entry name" value="ssDNA-binding transcriptional regulator domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcriptional coactivator p15 (PC4) C-terminal" evidence="8">
        <location>
            <begin position="37"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="120" mass="14244" checksum="56ED21732038E257" modified="2013-05-29" version="1">MSKHERVEDENEEKNVEKRIHTHSTEPFYDINGQAYWELGGRTRRLSISRWRGQVLIDLREYYEETATGQMKPGKKGLSLTQKQFEYLIKILPEVDAILKNMNKDVLNDSNEKKIYKNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRV1</accession>
    <name>M7NRV1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor CWC24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_01763</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the CWC24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873729.1">
        <property type="nucleotide sequence ID" value="XM_007875538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRV1"/>
    <dbReference type="STRING" id="1069680.M7NRV1"/>
    <dbReference type="GeneID" id="19895457"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01763"/>
    <dbReference type="eggNOG" id="KOG1813">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050460_3_1_1"/>
    <dbReference type="OMA" id="FICRKEY"/>
    <dbReference type="OrthoDB" id="25761at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16539">
        <property type="entry name" value="RING-HC_RNF113A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000045">
        <property type="entry name" value="RING finger protein 113A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039971">
        <property type="entry name" value="CWC24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 113B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930">
        <property type="entry name" value="ZINC FINGER PROTEIN 183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6 7 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="176"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR10007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="247" mass="28329" checksum="15EEF1E84799B931" modified="2013-05-29" version="1">MEPVKFIRKGRTKFVRKREEDSSSEDETVVKSKKVNFRQKHTTTNNNISTKSPLIESFESGSSNTTDSVITASDHTIKSNQTLSRPGPVQAKHVLPTTFIDYAPDVCKDYKQTGFCGFGDTCKFLHDREDYKAGWQLDHEWEQFQHKKRAAILHGNKYDTHTDDSSTEEDDIPFACFICRKEYVQPIVTKCGHYFCETCAIQRYRKNPNCIICGAGTSGIFNVAKKLQSRLLEKKQRIHEKHISSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRY5</accession>
    <name>M7NRY5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S8/S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01796</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873764.1">
        <property type="nucleotide sequence ID" value="XM_007875573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRY5"/>
    <dbReference type="STRING" id="1069680.M7NRY5"/>
    <dbReference type="GeneID" id="19895490"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01796"/>
    <dbReference type="eggNOG" id="KOG1153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_1_4_1"/>
    <dbReference type="OMA" id="QEDENGH"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031638">
        <property type="term" value="P:zymogen activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="160"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="432" mass="48119" checksum="DD473B0926F0F6EB" modified="2013-05-29" version="1">MKFIAKFIIFIIIGFIGSISSIPIIVFSENEYDDYIVIFRESVDNIKVQRHYLWIYDHLRWFQQYKKEKFGIDNENTNIHDWLKYEFNISDKLRGYHGRFLKEFVKYIGEYEDIAFVEKDQYVHALSLQKNAGWGLARLSHRNTLNFSTFNKYDFDSSSGQGVTIYIIDTGINIEHTDFGGRAKWGITVPSDCENIDDNGHGTHVAGIAAGSTYGVAKNANLVAVKVLRSDGSGLLSDVLKGIEWSIMMHLKDVESIKNKSSFKGSVANLSLGGIKSKILDYFVDIAVSLGLHFTVAAGNENDDACNYSPASSKAAITVGAATILDNKAYFSNFGKCVDIFAPGQNIISAWIGNNLATMPLSGTSMAAPYVCGLLAYLNSLIFRNSTYDIFFTSEMLKKKILDLGTKGKLHDIPPFTANIIAYNGYDENTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRZ2</accession>
    <name>M7NRZ2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription and mRNA export factor SUS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">SUS1</name>
        <name evidence="2" type="ORF">PNEG_02051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex required for deubiquitination of H2B and for the maintenance of steady-state H3 methylation levels. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. May also be involved in cytoplasmic mRNA decay by interaction with components of P-bodies.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least SUS1, SAC3, THP1, SEM1, and CDC31. TREX-2 contains 2 SUS1 chains. The TREX-2 complex interacts with the nucleoporin NUP1. Component of the 1.8 MDa SAGA transcription coactivator-HAT complex. SAGA is built of 5 distinct domains with specialized functions. Within the SAGA complex, SUS1, SGF11, SGF73 and UBP8 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with THP1, SAC3, SGF11, and with the RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ENY2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09871.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613304.1">
        <property type="nucleotide sequence ID" value="XM_019757737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRZ2"/>
    <dbReference type="STRING" id="1069680.M7NRZ2"/>
    <dbReference type="GeneID" id="19895745"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02051"/>
    <dbReference type="OMA" id="KLHECGW"/>
    <dbReference type="OrthoDB" id="6221744at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071819">
        <property type="term" value="C:DUBm complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03046">
        <property type="entry name" value="ENY2_Sus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018783">
        <property type="entry name" value="TF_ENY2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038212">
        <property type="entry name" value="TF_EnY2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12514">
        <property type="entry name" value="ENHANCER OF YELLOW 2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10163">
        <property type="entry name" value="EnY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0010">Activator</keyword>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09871.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="104" mass="12143" checksum="8BB94ADFE59BADFA" modified="2016-03-16" version="1">MSVPTETIVNLRAQVNQKLVESGAYERILFYLNKKLHECGWYSDMKNHALFKVRHQEKPNFEDLVKEIEPKGLATVPEDLKMEVLGMIKKFLEEVVTIEETDSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7NS60</accession>
    <name>M7NS60_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ADP-ribosylation factor 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_00037</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871888.1">
        <property type="nucleotide sequence ID" value="XM_007873697.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NS60"/>
    <dbReference type="STRING" id="1069680.M7NS60"/>
    <dbReference type="GeneID" id="19893735"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00037"/>
    <dbReference type="eggNOG" id="KOG0071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_9_3_1"/>
    <dbReference type="OMA" id="GGQISKM"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04149">
        <property type="entry name" value="Arf6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000286">
        <property type="entry name" value="ADP-ribosylation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041838">
        <property type="entry name" value="Arf6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR11593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="182" mass="20741" checksum="998BFAFBCDE56DAE" modified="2013-05-29" version="1">MGTSISKLMNRLFGNKEMRILMLGLDAAGKTTILYKLKLNQTVTTIPTVGFNVETVIYKNVKFNVWDVGGQDKIRPLWRHYYTGTQGLIFVIDSADRDRIDEARKELHRIISDREMRDSILLVFANKQDLETAMSPGEVTEKLQLDKIYNLWYVYPSCATTGEGLFEGLAWLSSNAKATLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTE6</accession>
    <name>M7NTE6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SRP9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873566.1">
        <property type="nucleotide sequence ID" value="XM_007875375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTE6"/>
    <dbReference type="STRING" id="1069680.M7NTE6"/>
    <dbReference type="GeneID" id="19895304"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01609"/>
    <dbReference type="eggNOG" id="KOG3465">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096859_1_0_1"/>
    <dbReference type="OMA" id="ICIRFRT"/>
    <dbReference type="OrthoDB" id="5419752at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039914">
        <property type="entry name" value="SRP9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039432">
        <property type="entry name" value="SRP9_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834:SF12">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05486">
        <property type="entry name" value="SRP9-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP9" evidence="1">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="113" mass="12824" checksum="BF7999A2ECE1BF70" modified="2013-05-29" version="1">MPLVKTVDAFLNLSYSLLQASPVTTRISTKYRFDEESKGFLTVKTYDPVSGICIRFRTDQAVDVSRLFLGKSRLGHVMANINVSLEQMLEQMANLTEQKVVESGKKHKKKSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTK1</accession>
    <name>M7NTK1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01315</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VAM6/VPS39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873241.1">
        <property type="nucleotide sequence ID" value="XM_007875050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTK1"/>
    <dbReference type="STRING" id="1069680.M7NTK1"/>
    <dbReference type="GeneID" id="19895012"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01315"/>
    <dbReference type="eggNOG" id="KOG2063">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004190_1_1_1"/>
    <dbReference type="OMA" id="EEYCNQV"/>
    <dbReference type="OrthoDB" id="5325112at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019452">
        <property type="entry name" value="VPS39/TGF_beta_rcpt-assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019453">
        <property type="entry name" value="VPS39/TGFA1_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF49">
        <property type="entry name" value="VAM6_VPS39-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10366">
        <property type="entry name" value="Vps39_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10367">
        <property type="entry name" value="zf-Vps39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CNH" evidence="5">
        <location>
            <begin position="7"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="4">
        <location>
            <begin position="621"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR10612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="907" mass="104729" checksum="E5A69A2776316BBE" modified="2013-05-29" version="1">MALNSVSFDLSGVISIVAHDDRVISGSSNGFLNDIRFAQTQPLHLPPVQVSQSPIRQIVCIYEAALIACLIDAQVILFDLHSLAQQGVLPRSNGALAISLISYLHMDELGIPIIISRLVVVFKRKISVYSWHDSELIANTIDLALNQRIKTLEWINSTKLCLCFISTCAFADISTGRIFKSISIKDFISLRPLRVLKTSANYIGYYKKTSKFIITRVSNDELLLTYNIKSLFMDSNGQLLERSPIIWSLEPTHIVYFHPYFIVVFNQHIEIRNIESYLIIQTFDIGNITCIFSGKYLFISTQSQIWKLSNIPFDNQVDDLISQNRLDDALMLFNRVNSVLFQNKTTKIRYIKMMKAYQLFNEGKYKNSMILYSESSSSPIVVISMFPIEIFDCEQYLNDSSISKYINASRIFLEKMCKKNGQISKDFNHPEFNIKAATRALVSYYLNDVRRKLSFLISSMSQFQESFQDILNGTLLPEYYFTLPDSNNALTLEEMEKLLEIVDTTLFRAYIFVSPDLVGPLVRLQNKIQLKVAKDLLEKNRRYKDLIDYFFRKSLHRDALDLLKKLGQGIISDSIYQEQFKGISEIIKYLKKLDNDYIEEIFSFIKWPLEVDSDFAMEVFLNDNQQLCLSKKKVYNFLLSLNENLAIRYLEYLINNLNDLTSEFHDFLIMHYFKNIEEHQESDNILEKLLKLLIDSKAYNSAYILEHLPKNNKLLEHKAIILSNLGRHKYALKIYLFEIKDFKKATDYCIKVYSMNNTESSDEIFLILLNLLLKPPDGHEIQLSNALDLLSLYRSYIKIETVASCLPLNIKISDIKLYLETSIQNKTTDIINGKIISSLHIANLMKYQNKLIDACNKKYTITSEKTCGNCHKRLGQSVLAIFPNDSIVHYGCQRAFLKAQNMPYTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTN2</accession>
    <name>M7NTN2_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01338</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873267.1">
        <property type="nucleotide sequence ID" value="XM_007875076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTN2"/>
    <dbReference type="STRING" id="1069680.M7NTN2"/>
    <dbReference type="GeneID" id="19895035"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01338"/>
    <dbReference type="eggNOG" id="KOG1539">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CIYAWRA"/>
    <dbReference type="OrthoDB" id="10250769at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059157">
        <property type="entry name" value="WDR36-Utp21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007319">
        <property type="entry name" value="WDR36/Utp21_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840:SF12">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25171">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25168">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04192">
        <property type="entry name" value="Utp21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR36/Utp21 N-terminal" evidence="6">
        <location>
            <begin position="60"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="289"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="490"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="573"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="WDR36/Utp21 C-terminal" evidence="5">
        <location>
            <begin position="706"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="914" mass="104608" checksum="F25826B84F17D42F" modified="2013-05-29" version="1">MNRFVEKRDSKHLKLSPKNENKDENENIKSSYLFSPFRTIGHVSNNIPFDIMIRGNSFLVSLCVGQNIQTYDCSKLNLLFVTPRTERKISSICSWGDFILAGAGQNIFAYRKGKIEWSIKQEDDEKVVLMSVLGGYLVTYTEKNNLIIWNILSREMYLKIEFNQNESVLCMIHPATYLNKFILGKKDGTLQIWNIRTGKLIHQFSSFKFSITCLEQPPVLDIIAIGLANGLIFIYDIKKDKELFQFKQDGKVTSISFRTDGPPIMCSSNDNGDIFIWDLLKKRILNVLYTAHFGSIVRIKFLEGQPLLLSSGIDNSLKEWIFDSPDSTPRLLKHRSGHSAPPSIIRFYQNDSHFILSASRDRSLRGFCIFNDSQNTELSQKPFVKKPISLKFSLEELRLPEILSFAVQPTKEKYWNNIITAHKGENVARLWSWKRKAIEKFVLKTSDKSSIKSVAISVCGNFGFVGSSLGTIDMYNMQSRFHRRKFCDDLNGHKKEITGIVSDSLNKTLVSSSLDGTIKFWKISTGKLIYTLDIKLPITLMRYQKSSDLLAIVCDDFCIRVIDIETTKIVRELWGHTNRITDLVFSYDGRWIISSSLDSTIRTWDLPVGCLIDAFRTPSICTSLDFSPTGDFLATTHVDNFGITLWTNKSQFSEVFVRSIQESEIKTINLPAISGENSSGIIDLSLKNIPNDTDIFFKTEYTSSKQINQMLTLSSVPRFKLNTLYNLDIIKLRNKPKEPPKAPKNAPFFISFLKDTSKDITPSILYTNESLEIDKSVSRIIKMKDLSVESQFTKLLKQGATQKDYMKFINHLKTLNPSSIDFEIRSLSPDSLFSEIIWFLDALTQSLKKQIDFEFIQICMAKFLNIHGDIFIENPNNDALQQSLINWEKEHKIINIKLKKLVDYCSGVLSFIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTT2</accession>
    <name>M7NTT2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PNEG_01231</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873150.1">
        <property type="nucleotide sequence ID" value="XM_007874959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTT2"/>
    <dbReference type="STRING" id="1069680.M7NTT2"/>
    <dbReference type="GeneID" id="19894928"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01231"/>
    <dbReference type="eggNOG" id="KOG0749">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_12_0_1"/>
    <dbReference type="OMA" id="CWATIYK"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000001">
        <property type="entry name" value="ADP,ATP carrier protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="9"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="114"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="214"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMR10521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="311" mass="33981" checksum="0946398CEBC3BE59" modified="2013-05-29" version="1">MANKTDPQSNFFIDFMMGGVSAAVAKTSAAPIERVKLLIQNQDEMIKSGRLSQRYTGIINCFSRTVKDEGIISLWRGNTANVLRYFPTQALNFAFKDKFKKMFGFKKDRDGYWPWFFGNLASGGCAGAASLLFVYSLDYARTRLANDAKSAKKGGERQFNGLIDVYKKTLASDGIRGLYRGFGPSVAGIIVYRGLYFGLYDSVKPVVLTGPLEGSFIASFVLGWIVTTTSGLASYPIDTVRRRMMMTSGEAVKYSSSFQAFSQIIAKEGSRSLFKGAGANILRGVAAAGVISMYDQLQMIVFGKKYSGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7NU06</accession>
    <name>M7NU06_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872807.1">
        <property type="nucleotide sequence ID" value="XM_007874616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NU06"/>
    <dbReference type="STRING" id="1069680.M7NU06"/>
    <dbReference type="GeneID" id="19894594"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00896"/>
    <dbReference type="HOGENOM" id="CLU_1496847_0_0_1"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="180" mass="21564" checksum="A75CE7322E85A180" modified="2013-05-29" version="1">MAEINKINPEERLQKELLKIYLFYISGFKDKLRIINQWKISEKGKKYLKFCCLFELHKQLNLIGYSLPVQKMPLYKLLLLPLLKCHDFSIVSSTIRRTSFLQQRIKNKLSFNYMFLFHLHFPAVLNEEVSIVLYNDILIIFNSTYTSIAKTMNVKELQTSHIWKRHDTELHFMYQDLKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NU91</accession>
    <name>M7NU91_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_00998</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SHO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872912.1">
        <property type="nucleotide sequence ID" value="XM_007874721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NU91"/>
    <dbReference type="STRING" id="1069680.M7NU91"/>
    <dbReference type="GeneID" id="19894696"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00998"/>
    <dbReference type="eggNOG" id="ENOG502QW7A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043316_1_0_1"/>
    <dbReference type="OMA" id="GFEPEFY"/>
    <dbReference type="OrthoDB" id="5983572at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007232">
        <property type="term" value="P:osmosensory signaling pathway via Sho1 osmosensor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11855">
        <property type="entry name" value="SH3_Sho1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000213">
        <property type="entry name" value="High osmolarity signaling protein SHO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035522">
        <property type="entry name" value="Sho1_SH3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="11">
        <location>
            <begin position="204"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR10852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="265" mass="30494" checksum="A6420F2E0A37AA3B" modified="2013-05-29" version="1">MYMKESQQMQSYFDISYLIDDIFLLGTIIFAFIGWIITVISLIVSNVREIDLPYYSWWVTVYQFFIIFCVITVILSNSGNTYRIALVGLITVALFSQALLCDTMLYYSKPSQRAIASGCIFLSIVDVLWILYYGTSNDSVYHLWTNSYISESSENIEKNFISKVTSDKDITSDDNHVAMTYTTQEHRPLNFLDSTVNSTAVQHEYPHKVKAIYSYNANPDDPREISFHKNEILEISDVTGKWWQARKHDGTVGIIPSNYVQLIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUH5</accession>
    <name>M7NUH5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA/pantothenate metabolism flavoprotein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872811.1">
        <property type="nucleotide sequence ID" value="XM_007874620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUH5"/>
    <dbReference type="STRING" id="1069680.M7NUH5"/>
    <dbReference type="GeneID" id="19894598"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00900"/>
    <dbReference type="eggNOG" id="KOG2728">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042326_2_0_1"/>
    <dbReference type="OMA" id="NTIRRCN"/>
    <dbReference type="OrthoDB" id="70224at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990143">
        <property type="term" value="C:CoA-synthesizing protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990181">
        <property type="term" value="P:acetyl-CoA biosynthetic process from pantothenate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/pantothenate metabolism flavoprotein C-terminal" evidence="2">
        <location>
            <begin position="34"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/pantothenate metabolism flavoprotein C-terminal" evidence="2">
        <location>
            <begin position="168"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="308" mass="36303" checksum="08900C7836029113" modified="2013-05-29" version="1">MDHETYFEMNKEPVLLKDCAQKVQDFVKIQLKLNSRVVLVTSGGTAVPLETQTVRFLDNFSAGTRGSASAEYFIKYGYSVVFLYRQHTLLPYSRCYFHNKYDFLDYFEETDNCNVMVKAKYREKMVHHLRCYQDAKLNNKLLMISYLTITEYLFYLREIAIIFRPLSRNALFYLAAAVSDFFIPPERISEHKIHSESNDKRLVIEFDPVPKFLAKLIEKWAPRASIVSFKLETDEDILISNARMSLQRYGHRLVIGNILTKRKYEVVFVTETQESWIRLTQEEKDNGIEIESKIVPRIIQLHDTWIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUI0</accession>
    <name>M7NUI0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR10962.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613312.1">
        <property type="nucleotide sequence ID" value="XM_019757724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUI0"/>
    <dbReference type="STRING" id="1069680.M7NUI0"/>
    <dbReference type="GeneID" id="19894264"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00566"/>
    <dbReference type="eggNOG" id="KOG2048">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2004866_0_0_1"/>
    <dbReference type="OrthoDB" id="8883818at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046351">
        <property type="entry name" value="UTP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10962.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="149" mass="17624" checksum="AE750DF9690C78A3" modified="2016-03-16" version="2">MSTSRHEDKLVGYDFGNEDTLLWAIKNLENEVMVIGYSMESVKFWDQKYYLLLWSFKSHTAGVLCLSSNKEYFIFSGVDCKTIMYRIINKENQQWADVGYRYSSNKKVKKLKVHSLEFIGETILLFDQRLNFVIAHLKLIFCIYVHRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUK8</accession>
    <name>M7NUK8_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trehalose-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872826.1">
        <property type="nucleotide sequence ID" value="XM_007874635.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUK8"/>
    <dbReference type="STRING" id="1069680.M7NUK8"/>
    <dbReference type="GeneID" id="19894612"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00914"/>
    <dbReference type="eggNOG" id="KOG1050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002351_2_2_1"/>
    <dbReference type="OMA" id="TSWDKRR"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000036">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF15">
        <property type="entry name" value="TREHALOSE SYNTHASE COMPLEX REGULATORY SUBUNIT TPS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082678" evidence="2">
        <location>
            <begin position="17"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="894" mass="103912" checksum="B5BA39F5DC151E71" modified="2013-05-29" version="1">MPKLYVVCLFLPNTLSFDLDETDSIKLNPQRSNYKKEPIPHLINKLASCSENFQDTNCNISLSNDEETRFFYLLKDKNVLENEKNREDEDEMFEGRKKELNQPKFKSRVSSLSTAISQISTKGKSSYTMQNYPHAPILASRRRRSSFDVNLFSKVPWTIELNDQSNVGLGNAIRAADKSGNLQEHMFIGLLGIPTDSLSIMRKYEVEREFMTKCRSIPIFVSDNEFDNHYNYYCKQILWPIFHYQIPDIPKFKMYQDYSWNHYVALNQAFANKIIENYNDGDIIWVNDYHLLLVPQMIRQKLQYAMIGFFLHVSFPSYEVFRCLSVRKQLLEGILGANVIGFQTDEYAYHFLQTCTKLLNVKMSSRNIQFGSSFVNICDLPIGIDPDNLEKKKTLSSVKLWISLLKERYSGKSLIVGRDKLDEIKGVRQKLLSFELFLNKHSEWREKVVLIQVALSTSEENETQSQVSNIVLRINSTYGNLSHQYQPIVFLRQDITFSQYLALLTVADAFLVTSLREGMNLTSHEFVFCQRGNYGPLIISEFAGSAARFKDAAITINPWNLNQVSNAIYQALTMSSKERLIRWEKLSDTIMNHDAAHWAINFINEIKCNSFFQEKKKDIHVPKLQLDLFAQKYDNSKICIFFLDYEGVFLNLGNHLNDFHTNKEKVISVLSSLALNPKNIIYIMSHSNIKDTEKFFEKIPNLGFITQDGYYICHNNNQINPIFGNDIAWKTSVKEIFSYYSERIPTSYIEELPFSVIFHYNSKDIESYTSWEIDEFTKHVSYSFSNISCHTIFMENEVVIRQNNIDKSTVICNTLEYIKELFGNSKKIVFIAGDNKNDENVFDWAIKFKNNNETDYVLTVNIGTKDTKALTWVDHVSEYFEILEKLAILSIQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUR9</accession>
    <name>M7NUR9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872549.1">
        <property type="nucleotide sequence ID" value="XM_007874358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUR9"/>
    <dbReference type="STRING" id="1069680.M7NUR9"/>
    <dbReference type="GeneID" id="19894349"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00651"/>
    <dbReference type="HOGENOM" id="CLU_183941_2_0_1"/>
    <dbReference type="OrthoDB" id="15108at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39476:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39476">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE 6.6KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="55" mass="6243" checksum="42108FEFAAA5E900" modified="2013-05-29" version="1">MRASQHTYFKWTPKTVVASLVLGIFVPSCIGYLALITEGRWNFRGKGIKDKLTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M7NV63</accession>
    <name>M7NV63_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872678.1">
        <property type="nucleotide sequence ID" value="XM_007874487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NV63"/>
    <dbReference type="GeneID" id="19894473"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00775"/>
    <dbReference type="HOGENOM" id="CLU_1129473_0_0_1"/>
    <dbReference type="OrthoDB" id="5416916at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="118"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="246" mass="28779" checksum="48D51DB568F13E69" modified="2013-05-29" version="1">MRFSLGLSENTLEDITPLNKDLEINKNSINDLDNFHISLRTFLSSGIKKDYKRSKSSSPRKPLQLKKNINDDNLFNISEGVKSIQNAPCVQFSTAKILPSKKIYSESGTLKKPWTPQRIILQQENESLKKYINELKKALKEKKEDFDNNVDNNIIKKLRNLVDFVQIESNIYLKTKDSELNKTLKEFEEIKLENEKLKKQNSYILEMWKLEKDRVKRREKQLGVEQMKNKQISAQLGILEEAMMNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVB3</accession>
    <name>M7NVB3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872573.1">
        <property type="nucleotide sequence ID" value="XM_007874382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVB3"/>
    <dbReference type="STRING" id="1069680.M7NVB3"/>
    <dbReference type="GeneID" id="19894373"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00675"/>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_371767_0_0_1"/>
    <dbReference type="OMA" id="THVNEIF"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="11"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR11076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="748" mass="86566" checksum="14B794880B09566B" modified="2013-05-29" version="1">MVKPELDGSVNYYECLQVLPTASADDIRQQYRKLALLYHPDRNPGNEAEFKRKFQSLNMAYEVLSDAEKKKSYDRARLIVLSSKITQNKKESSCGMKSPFRSSFTSSFAPKTPAHSRSPGSPHSSKSSPSSKSKYTSQSKRSEDIYAGYENWFSKSTSAYSFFYERNSPKFDPRKPSYTSPFGSPIPKKQDEEKSFAKAKDDARKAAASKYAETRMQYEKENLKDIFKKNTQTSDEKASSKHTFFDIKSKAEHKDEVCLQSRGDNTLNHQNIFTEKKIPCEKTSEFFSFSLSKKKESENTQPAEQPIVFEKFSNTELNESSFSFSSIPTDLKFGTQTTHVNEIFQSNDSKEIRFNSLKNTLKQNKKRNTTRSLRHLSSQIETGFNPVFSTKIPDNWCSNKETFEKNNSTKENNEDLNLKKKNSNLFDNNLEKNPTLSSSKISFTIKKPSFLKIENPFAFDSSSKEIKKKVLLDDTCETFKNITGTFQDRYNEKYDKKTENKFKHVSQKSVEINSADSSLLSERVKKELESYRNFKISYETEKANKNINKLSINKSHVLEQFQDLTLSASKSSETNKKSASVETSKSPSFIEFSRFQVNTEKHLQDLWNTNDDSNIPTNMEKKAKILNIPDLPDPVIPLLSPSIPNCFTISSFSTYLKEMIKYQQIWLGYSSTYLKFFQKWDKYKELCHQYDLLKDADIYEAFVMATEKEEKIREGWWSEEKRYRQALKDFLHIKKSYEYGQKLPFGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVB5</accession>
    <name>M7NVB5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6B homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_00816</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872723.1">
        <property type="nucleotide sequence ID" value="XM_007874532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVB5"/>
    <dbReference type="STRING" id="1069680.M7NVB5"/>
    <dbReference type="GeneID" id="19894514"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00816"/>
    <dbReference type="eggNOG" id="KOG0727">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_2_0_1"/>
    <dbReference type="OMA" id="QDIGGMD"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045899">
        <property type="term" value="P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000046">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000033">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="197"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR11227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="418" mass="47151" checksum="F05C03F7A915DE89" modified="2013-05-29" version="1">MENDNDYLENSCRTDSVSKKETKGPQNSIFPKTVMSNDPYIRLKYLQRHLEMLELQETFIKNDQKSLKRELVRAQEEVKRIQSVPLVIGQFLEAIDENTAIVGSTTGSNYIVRILSTLDRELLRPFSSVALHRHSSALVDILPPEADSSIAMLRPDERPDVTYQDVGGLDMQKQEIKEAVELPLTQADLYKQIGIDPPRGVLLYGPPGTGKTMLVKAVANSTTASFIRVVGSEFVQKYLGEGPRMVRDVFRLARENAPSIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQGSNVKVIMATNRADTLDPALLRPGRLDRKIEFPKTDRRQKRLIYNTIASKMSLSPEVDLDSFILRPDITSGAQIAAVMQEAGLVAIRKSRYLVIHSDIEEAYRSQIQEADSEKFTFYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVK6</accession>
    <name>M7NVK6_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Biotin-[acetyl-CoA-carboxylase] ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00351</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the biotin--protein ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872224.1">
        <property type="nucleotide sequence ID" value="XM_007874033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVK6"/>
    <dbReference type="STRING" id="1069680.M7NVK6"/>
    <dbReference type="GeneID" id="19894049"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00351"/>
    <dbReference type="eggNOG" id="KOG1536">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006150_1_1_1"/>
    <dbReference type="OMA" id="HHAFYSN"/>
    <dbReference type="OrthoDB" id="10250105at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin--[biotin carboxyl-carrier protein] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019197">
        <property type="entry name" value="Biotin-prot_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835">
        <property type="entry name" value="BIOTIN PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835:SF5">
        <property type="entry name" value="BIOTIN--PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09825">
        <property type="entry name" value="BPL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="383"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR11322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="682" mass="78573" checksum="ECBF5979B23E2DD0" modified="2013-05-29" version="1">MEVLIYTGILNIERKNIKMVLINFIFILDIETSKLSVRQTFSVFHFLLGSYYVIKKADKSYLEQRSTWDNVALFIMPNSEDIIYNNGLGEIVSEKILKYLKNGGKYIGIAAGGYYASAYTEIESNNTQKKQNKLSKFVIFPGIARSIDFSKYICSNDSNKHLALIHIEDESYKYENDLYYYHSGVSFVNADQFLNTRILATYKEINPNNKTPPNAAIIHCKIGKGEAVLFGVHPEYSGFNTDLKDNTRNYLEDFDRLLLFENNRTIFLRHILQSLGLRTTSKPIISSEITNLHLFSKFSNLIKEITNILYNISEIINGERVIRCENDSFYLQKSSTYTFSQNPLNNFHDYDYEIIPKYIKIHKHLPTILEIPFFNHEIYFKNLLASRTLKKEKKYMGNIILYGETVSSSQTLLNKNLKLLRVLPTGFVFVATQQIAGKGRKNNVWISPQGVLAYSLIIRQPEYLIFSSIVFIQYLVSLAIVEAIKTYDNHYNELDIHIKWPNDICVKQSEENTIEPSFILNNIGYIKIAGILIDCKHIDNEFLMIIGCGINVSNFLPTTSLEIIIKTLNARKILEKQPLLSEITQEKLLARIMTTLESMYYEFCLNNGFKLFEHQYYKYWLHTGQIVTLEDNSNAVITGINPIHGGLNAEGIENGKKNGKIWELYPDSNSFDMIKGLIKKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVL1</accession>
    <name>M7NVL1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U2 small nuclear ribonucleoprotein A'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00774</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the U2 small nuclear ribonucleoprotein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872677.1">
        <property type="nucleotide sequence ID" value="XM_007874486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVL1"/>
    <dbReference type="STRING" id="1069680.M7NVL1"/>
    <dbReference type="GeneID" id="19894472"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00774"/>
    <dbReference type="eggNOG" id="KOG1644">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061027_1_0_1"/>
    <dbReference type="OMA" id="PNYREYM"/>
    <dbReference type="OrthoDB" id="433501at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000026">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044640">
        <property type="entry name" value="RU2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552:SF6">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="234" mass="26587" checksum="3F05359D9D4BAB84" modified="2013-05-29" version="1">MRLNIDLLNNAPSYINPAKERELDLRGHKIPAIENLGVTKDQNDAIDFTDNDIRFLGNFPKLIRIRTLLLSRNRISSISSQLSSTVPNLRTLILTSNSISELSDIRCLSGLRKLTFLSLMDNPVSRKENYRLWVVWICSSLRVLDFSRVRQYEREAAKVLFGVSISEPTALAESILGVKSHAFDIHESTDEGKDNFKLTDDERKRIQDAIRNATSMSQVVKLEAMLNEGWVPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NW74</accession>
    <name>M7NW74_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUS-like FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00406</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872282.1">
        <property type="nucleotide sequence ID" value="XM_007874091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NW74"/>
    <dbReference type="STRING" id="1069680.M7NW74"/>
    <dbReference type="GeneID" id="19894104"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00406"/>
    <dbReference type="eggNOG" id="KOG2334">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013299_3_1_1"/>
    <dbReference type="OMA" id="KEYSILW"/>
    <dbReference type="OrthoDB" id="10262250at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102264">
        <property type="term" value="F:tRNA-dihydrouridine20 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052582">
        <property type="entry name" value="tRNA-DUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="9">
        <location>
            <begin position="3"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="245" mass="27217" checksum="29B8FD7DB7AFA9E9" modified="2013-05-29" version="1">MEKSKLIFQLGSADPELAVKAARLIAQDVAAVDLNCGCPKHFSVHSGMGAALLKNVDRLESILIALVKNIGIPYNIGISAKIRILEDIKETEALVRRICETGIIGLTVHCRTISMRNKEKAIRDQLKMISKICREKGVACIANGDIIDRKNGLEVIKEWDIDGAMIARAAKKNPSCFRMEGLLSQIEVAQEWLRMAIQTGNSFSNTKFCILQILDDKSISRKTVFQPFQNAKSFFEMVKILGIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWY2</accession>
    <name>M7NWY2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00109</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871966.1">
        <property type="nucleotide sequence ID" value="XM_007873775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWY2"/>
    <dbReference type="STRING" id="1069680.M7NWY2"/>
    <dbReference type="GeneID" id="19893807"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00109"/>
    <dbReference type="eggNOG" id="KOG2920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038704_1_1_1"/>
    <dbReference type="OMA" id="NLLLTWH"/>
    <dbReference type="OrthoDB" id="1723750at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045903">
        <property type="term" value="P:positive regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="304" mass="35167" checksum="F8B063DD2FA44B12" modified="2013-05-29" version="1">MDAYNEDTSSNISSLPPKRHTLEELIEFLPENISFDVLKVDFKEYSSYKTLLPKRAIWDIRLQLMAYDYDTSQSELLFLTGSSDIIPNVYEGGYKTWECSYDLVEYLSKTSLKYSKLGCGSALPSVVLFIQTLLYSRNQAVNFTFQDYNISVLKFLTIPNLFLAWAIIKNQEIASMKEMNITNTIKEEFLSDLIEKKITINFISGGWCDKMNHLILDKHDLILASETIYSKQNLNTFINILAYNIENHKESKALIAAKKTYFGLDVSIEDFIRKLEEFHLNYSYVYESINTGIVRVILNIESFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWY7</accession>
    <name>M7NWY7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">ER membrane protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00114</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871971.1">
        <property type="nucleotide sequence ID" value="XM_007873780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWY7"/>
    <dbReference type="STRING" id="1069680.M7NWY7"/>
    <dbReference type="GeneID" id="19893812"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00114"/>
    <dbReference type="eggNOG" id="KOG3188">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060791_0_0_1"/>
    <dbReference type="OMA" id="KDMDPRW"/>
    <dbReference type="OrthoDB" id="6745403at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045050">
        <property type="term" value="P:protein insertion into ER membrane by stop-transfer membrane-anchor sequence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008568">
        <property type="entry name" value="EMC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116:SF5">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010045">
        <property type="entry name" value="DUF850_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR010045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="276" mass="32048" checksum="1D7BB94998C28AEC" modified="2013-05-29" version="1">MDLKKSQDLYLDKSLRNWVLFSIFIVMILTGIMKHYISILLLETPRKMTVKEIREIRALQRSEILRVNCNHIPFAAFYARKTFLIKAFSNGEYLENPELRGSQLMNPMINLKNMDQMMRIFKSNMANIIPQTIIMAWINFFFNGFILIKLPFPLTLRFKSMLQSGVATDDLDVSWVSSLSWYFLNFFGLKPIYDLILGDGNFASGGETTGIEMAIPGMIESNSNMSDLQSYIPSGTDPDKLFSIEIENLELVMHKWILEDVEDRILEKYQNMEIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M7NX24</accession>
    <name>M7NX24_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872006.1">
        <property type="nucleotide sequence ID" value="XM_007873815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NX24"/>
    <dbReference type="GeneID" id="19893843"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00145"/>
    <dbReference type="HOGENOM" id="CLU_2159490_0_0_1"/>
    <dbReference type="OrthoDB" id="10324822at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="111" mass="12848" checksum="748EE304348FACF3" modified="2013-05-29" version="1">MLNFWDLNIKRHTSFKNRTITPSGISLPLESKSAPQLSKVCNTSIPSFTCNNFGENYNQSNNHSCGSSIYEENVLKERENIEETEISEGILKFTAEDYIQEIQKIEKQYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7P2J9</accession>
    <name>M7P2J9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Brix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_03548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875641.1">
        <property type="nucleotide sequence ID" value="XM_007877450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P2J9"/>
    <dbReference type="STRING" id="1069680.M7P2J9"/>
    <dbReference type="GeneID" id="19897235"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03548"/>
    <dbReference type="eggNOG" id="KOG2963">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026936_1_0_1"/>
    <dbReference type="OMA" id="KRTHAQI"/>
    <dbReference type="OrthoDB" id="10261452at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045112">
        <property type="entry name" value="PPAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661">
        <property type="entry name" value="PETER PAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661:SF5">
        <property type="entry name" value="SUPPRESSOR OF SWI4 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="25"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="323" mass="37189" checksum="4CE371EFF29310DE" modified="2013-05-29" version="1">MVKTKKKRTHLRKNEELSNTRIPKSMVIRAGASNVGSSISQLARDIRRMMEPHTAVRLRERKANRLKDYIAMSRPLGITHLLLLSKTELGPNMRIIRSPHGPTLYFRIKTYSLCKDIIKTQKNPRSPGSEFLMPPLLILNNFISGKKELPHETLLTSTFRNLFPEISVKRTQTSYIKRTLLLHRDPCKGYIDLRHYAIVTKNVDICQPIRRISTNLGIKKKPLPNLGFIKDISEYVLHNTGFISCESDSEIDDDAIVEVKEETNMKNYSKEKIQKKAIKLIELGPRLQLELYKITEGVSEGNILFNKSISNTLNEEINFKEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3B3</accession>
    <name>M7P3B3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pheromone alpha factor receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875208.1">
        <property type="nucleotide sequence ID" value="XM_007877017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P3B3"/>
    <dbReference type="STRING" id="1069680.M7P3B3"/>
    <dbReference type="GeneID" id="19896835"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03148"/>
    <dbReference type="eggNOG" id="ENOG502QTV4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035056_1_0_1"/>
    <dbReference type="OMA" id="VSICYFS"/>
    <dbReference type="OrthoDB" id="5402633at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038038">
        <property type="term" value="C:G protein-coupled receptor homodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004932">
        <property type="term" value="F:mating-type factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.920">
        <property type="entry name" value="Pheromone alpha factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000366">
        <property type="entry name" value="GPCR_STE2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027458">
        <property type="entry name" value="STE2_TM1-TM2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28009">
        <property type="entry name" value="PHEROMONE ALPHA FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28009:SF1">
        <property type="entry name" value="PHEROMONE ALPHA FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02116">
        <property type="entry name" value="STE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00250">
        <property type="entry name" value="GPCRSTE2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="41594" checksum="9389032B26CAFEE4" modified="2013-05-29" version="1">MAFSPTNQTIFLKNSKGETIPFLLSDFDEFSLSRAQTSMIFSAQCAMSLLLALVLMLTSKREKRKTLLFFLNIGGLVTVFIRACLQCAYLSGTWVSYSVQFLGEFELLSQKDFYISIIASCIPIFIILFIELSLLIQIRVVYATDKRLQIPLTIFFSIIIIIVITFWILAAVQNSMAVLSQTHFGHSGVWGAPWPYTVARISFAFSIFIGCIVFIYKLLITIYRRHKMGVKEFGPIQIIFIMSCQTLIIPAILILIDFGVKITGFSSLTQALVVMSLPLSSLWASSKVEKNKNNVTPTYYKDMKSIGDYSIESTPSSFTKPSYIGFRKPSYFSEYSKSPFYDEYFDDNGSKLDILVEKSLNVFPEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3C8</accession>
    <name>M7P3C8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit K</fullName>
            <shortName evidence="4">eIF3k</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">eIF-3 p25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_03165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit K family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875228.1">
        <property type="nucleotide sequence ID" value="XM_007877037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P3C8"/>
    <dbReference type="STRING" id="1069680.M7P3C8"/>
    <dbReference type="GeneID" id="19896852"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03165"/>
    <dbReference type="eggNOG" id="KOG3252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076723_0_0_1"/>
    <dbReference type="OMA" id="GDDLCAD"/>
    <dbReference type="OrthoDB" id="337745at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.250">
        <property type="entry name" value="ARM repeat, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03010">
        <property type="entry name" value="eIF3k"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009374">
        <property type="entry name" value="eIF3k"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016020">
        <property type="entry name" value="Transl_init_fac_sub12_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="55"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="241" mass="27853" checksum="BBB49D546DDA59FA" modified="2013-05-29" version="1">MTFDFEFSHFPSIAAIPSSRSSVIQHLIDGVDRYNPQNAPLLEEYLMQQCQDGAYDCLANLAILKLYQFNPHLSKDEVITNILVKALTVFTQPDFSVCLHLLHPSVLLPREVFIGDSLHEIVQKLHTLYLLLDAAKYKEFWQLIDNDDLYADMIADCIGFEDTIRLGIAKVISQTMKEVKLDILEEWINLHDEKLKIWIHDVFHWEIVGEIVKLPENKDNILLSKATSEKIPFTDLYQLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3G7</accession>
    <name>M7P3G7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein SYS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_03215</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875278.1">
        <property type="nucleotide sequence ID" value="XM_007877087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P3G7"/>
    <dbReference type="STRING" id="1069680.M7P3G7"/>
    <dbReference type="GeneID" id="19896902"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03215"/>
    <dbReference type="eggNOG" id="KOG4697">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081382_0_0_1"/>
    <dbReference type="OMA" id="EYEMVGM"/>
    <dbReference type="OrthoDB" id="542931at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019185">
        <property type="entry name" value="Integral_membrane_SYS1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952:SF0">
        <property type="entry name" value="PROTEIN SYS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09801">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="21088" checksum="70A8BEA32E8C7A1A" modified="2013-05-29" version="1">MISRRNSLDFALIISQIIAFQSLFYLSQTVLIQFMLYVLEKPVSLDYIFDFHKITLDNNESAVTGLVWDINSIFGVLIIFFVVRRSKQVLDFTLTMHFIHFIIVFFYSGSLPTNTYWWIVQIISCIFICLGGEWICMQRELKPIFFGSWQNLPMIESNPNIEQYELDKIDAQKHYEALC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3J3</accession>
    <name>M7P3J3_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875313.1">
        <property type="nucleotide sequence ID" value="XM_007877122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P3J3"/>
    <dbReference type="GeneID" id="19896933"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03246"/>
    <dbReference type="HOGENOM" id="CLU_314253_0_0_1"/>
    <dbReference type="OrthoDB" id="5373489at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="931" mass="107173" checksum="727A7669638D8A34" modified="2013-05-29" version="1">MEDEDEIDRRSLKEIWKRRKHPRKEEKGHWFYGIHCQTENTELYKLAASLKSKTLVNTEEKYNHEELYSPERFMHEKQCGDMFKENFSLSYESKSPKKTSNKSKRSFFWLPEIKGLKKEKQNHTLEYDLKTSNPPTFIDMYGTISENNIKIPHPLNPVEQPIKNVYQEKSELPEKQRISKNISSISKTDFLLSKLLDCFSKQPKILETKGTQTSKYSTPTTEMNHTYQTYTQTSSSIDSHISSQIFVDARETFMPSPVEEINLYKPKRENIRKKDEENPRGYSGIHCLCQKISLRRTLFPPSVSPCKLYTIKNMGNYEPQRCYESKYINYPFRRKMQISPKNITPSQSSIYSFTPFMKTRIPPTEISQKNVSPNFIIKKELSSPFSYEAKADYSTLQYLELLSNEEDYINNDSKCIKKKSIIDESLGMKFKNEINQDKKALFSKKVDLSLTNDNIINYQNPENDLFDISELENKINSMLSALSTENKSNILTRLQEKAVSKNNLESILRDEKPLGKMENIKKNAMSKQISSNHTKSDIFSEANFEKKGKVRIPSIFLNKNKSSPLQPISKTPGLTVSSQNIKITQDICPKITSSSKNISKKENSRPQDSIITNIEKNNNNQTHVPMEKETDSFLFKSYTKKEHQKSSSPATNLDRQKLATIQDINSRKNKSSPLALKNTSMSQLYKKSSNTYSSITHNTSTFDSENFSKNNQIPLKKSVKSFNTGCKVIIPPVFLLEKDNDVNNNNILKESVSLNRLPSDSALNSTLLNRKNSESYNKKANNYHQKFKLDNFNESKKISSLPDIKRSFIENICPQSKLTSKNNQNKSDHSSTSSSFYCKQEYKNDSKIGFTSSGLKKTRVDSKIDIPTNFSDISTKTKDVFGDKSPRHKYLVSAYQEAINISTISSKTTKINELNRTQPNKIIIPSIFTMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M7P462</accession>
    <name>M7P462_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875182.1">
        <property type="nucleotide sequence ID" value="XM_007876991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P462"/>
    <dbReference type="GeneID" id="19896810"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03123"/>
    <dbReference type="HOGENOM" id="CLU_1644429_0_0_1"/>
    <dbReference type="OrthoDB" id="5374757at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="161" mass="19244" checksum="AD58059394DB061A" modified="2013-05-29" version="1">MSHSIINRKYLQISKDLVIEMRLFLDNPYPLCLSNSLLRNIVDLIKPSVILKLQKEQLQKQKKNMKDLIEDDRFKITLFFVPSKSCNFLLKRVNDFVFLLEEKDKSTIDHFTENTTTITNFDIKEDSEAFIKPMSIITYKKYSIYKKILYVKVNFKDYKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M7P4R0</accession>
    <name>M7P4R0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875021.1">
        <property type="nucleotide sequence ID" value="XM_007876830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P4R0"/>
    <dbReference type="STRING" id="1069680.M7P4R0"/>
    <dbReference type="GeneID" id="19896661"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02974"/>
    <dbReference type="eggNOG" id="ENOG502R7M9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_602855_0_0_1"/>
    <dbReference type="OMA" id="KSHALMM"/>
    <dbReference type="OrthoDB" id="5354116at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="496" mass="56257" checksum="BBC9475A2392D222" modified="2013-05-29" version="1">MTNKHSNQNSMVQKIQSSDSLRQKKKNESLSNLEEIISSSGNMERTLEDLYYVFSGTPGGSLVLKQSLDEDKKNSKNASTISLKLQKKTYNSLAALESDLYTAVTLLLNNIRPTDTDYALVSSFYTFSRKLLIREQKHSITQALGSDAKKYTQDSFPFRSPSNECLFVISPNGPLFSSLAAKSVFDTRPINTEGRAYITQVIPNYSASTKSIQTFANICPASSQSESSALKKRKLKHPTLKLIPSVKWLYYNSYSSYAPTKDMETAIFSEKHLNAVWWKRKNEKLSMKQKKEKDIEKDATKQSDIDQPSTLELDEKLILSYEPINISDELKASKLYKEYNDVNINEIGKLIQTLSEMQSLRIARSQTEEPGELEEQLAFHIQQLLLKQIVSFNLQPRELLPKPLSLSMSFLVLGPSYTGTLPNVPLMSSAEEFRNQHGSYSELQNYTRNEGSYNQNSQKISNIPITLPSLIRNDSYRSFLNSSLSAYRKIGNRTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M7P5N9</accession>
    <name>M7P5N9_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell differentiation protein rcd1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874540.1">
        <property type="nucleotide sequence ID" value="XM_007876349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P5N9"/>
    <dbReference type="STRING" id="1069680.M7P5N9"/>
    <dbReference type="GeneID" id="19896221"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02529"/>
    <dbReference type="eggNOG" id="KOG3036">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IFIVQKF"/>
    <dbReference type="OrthoDB" id="1183224at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033620">
        <property type="term" value="C:Mei2 nuclear dot complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000014">
        <property type="entry name" value="Cell differentiation protein RCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007216">
        <property type="entry name" value="CNOT9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12262">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04078">
        <property type="entry name" value="Rcd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="345" mass="38538" checksum="691D8328DE5A7428" modified="2013-05-29" version="1">MISPVSGSAFGSSQYLHYSIPKTQQQMISDAFNTTNFPLSRTSPGFGTSAAFGNAFLGSRGDDGHQNLPDNIKMYNWIIELISGNVGREHALLELSKKREQFDDLAFILWHSFVKIGVMTSLLQEIVSVYPLLLSPQLTSHASNRVCNALALLQCIASHNETRTLFLNAHIPLFLYPFMSTTSKSRPFEYLRLTSLGVIGALVKNDSTEVINFLLSTEIIPLCLRIMETGSELSKTVAIFIVQKILTDDMGLAYICQTYERFYSVGTVLSNMVSQLVENQVHRLLKHVVRCYLRLSDNPRAREALRQCLPEPLRDATFSNILKDDLSTKRALAQLLVNLSDSVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6A0</accession>
    <name>M7P6A0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02332</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874334.1">
        <property type="nucleotide sequence ID" value="XM_007876143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P6A0"/>
    <dbReference type="STRING" id="1069680.M7P6A0"/>
    <dbReference type="GeneID" id="19896025"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02332"/>
    <dbReference type="eggNOG" id="ENOG502QUQ4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026011_0_0_1"/>
    <dbReference type="OMA" id="IDPHPLA"/>
    <dbReference type="OrthoDB" id="545910at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF4">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="5">
        <location>
            <begin position="234"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="GRF-type" evidence="6">
        <location>
            <begin position="351"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="409" mass="47954" checksum="A43D1D2329C865B1" modified="2013-05-29" version="1">MIYDNDENDTEIKLALLSSIFPDKSIETLLEKLVENNGIVENILNVNSQSDFKNENALLKRKKQRKIEEFIENDEYKHKRTFVSGKLSSDTLWPIKMQNDSFERSKRVNVHVQHLYFPDQIAKLTPCTLIHNFLGKDLCNSLLLKMLKESETWERNEFRLFERKVVSPHKSCYYLYSDENKLLEQKFFHNGLEIKNVREFSEEMNVVRLLVKDIVNKILSKRENLEYQYPGEWDPNIVVANLYSNAKENLGYHSDQLTYLGPMPTIACISLGTEREFRLKRVGFEHNESVKSIHLPHNSLLIMHSPCQEDYKHSIHPAHTVMLHPISGTIRISITYRFCRKTYQPKYIPTCKCNIPSVLRCVQKKRSTKGRYFWSCNANKLVNGNGKGCQFFQWAVFTKDGENILAYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6V6</accession>
    <name>M7P6V6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SF3B5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874187.1">
        <property type="nucleotide sequence ID" value="XM_007875996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P6V6"/>
    <dbReference type="STRING" id="1069680.M7P6V6"/>
    <dbReference type="GeneID" id="19895897"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02204"/>
    <dbReference type="eggNOG" id="KOG3485">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138804_3_1_1"/>
    <dbReference type="OMA" id="YDRFNIH"/>
    <dbReference type="OrthoDB" id="274726at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009846">
        <property type="entry name" value="SF3b5/RDS3-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017089">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978:SF0">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07189">
        <property type="entry name" value="SF3b10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037010">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="85" mass="9867" checksum="387FEF1D289FE95B" modified="2013-05-29" version="1">MADKLRIQSQLEQLQQKYVGTGHADTTKYEWIANQHRDSYASYLGHPHMLNFFAVASNDSRERVRLNMIEKMVLPCGLPIVKDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7P7U6</accession>
    <name>M7P7U6_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polyubiquitin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01699</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873662.1">
        <property type="nucleotide sequence ID" value="XM_007875471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P7U6"/>
    <dbReference type="STRING" id="1069680.M7P7U6"/>
    <dbReference type="GeneID" id="19895393"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01699"/>
    <dbReference type="eggNOG" id="KOG0001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010412_0_0_1"/>
    <dbReference type="OMA" id="MSDEHTL"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000004">
        <property type="entry name" value="Polyubiquitin Ubiquitin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="153" mass="17195" checksum="17906CF7197EFDF8" modified="2013-05-29" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7P8N0</accession>
    <name>M7P8N0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_01483</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873422.1">
        <property type="nucleotide sequence ID" value="XM_007875231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P8N0"/>
    <dbReference type="STRING" id="1069680.M7P8N0"/>
    <dbReference type="GeneID" id="19895179"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01483"/>
    <dbReference type="eggNOG" id="KOG2085">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012437_1_2_1"/>
    <dbReference type="OMA" id="LIYPEVI"/>
    <dbReference type="OrthoDB" id="10264446at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070199">
        <property type="term" value="P:establishment of protein localization to chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901991">
        <property type="term" value="P:negative regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031107">
        <property type="term" value="P:septin ring disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031134">
        <property type="term" value="P:sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000016">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR10210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="622" mass="72647" checksum="EC3C87C447ADBC57" modified="2013-05-29" version="1">MKGFRNKVLLRTKSSSESNKGSQNSKTKDLKERAGVSEKKPERSLKLKDSFRQLAQSAFSIPSIPASVTNVPLYMNTTSMHLTSSGVSEIISGDLTLLKHGTKTGAFERLQTTPKDSAALDAIKTPKRNTSSRFRISTEQELEKLPSFHEVPLNNRQDLFVQKLKQCNVIFDFTNASMDMRSKEIKRETLHELLEYVTNNRNVITEPLYSKVIDMFSTNLFRPIPPPVNTYGECYDPEEDEPVLEVAWPHLQMVYEFFLRFIESPDFNTNLAKSYIDHHFILQLLELFDSEDPRERDLLKTTLHRIYGKFLTLRSFIRKSINNVFFQFIYESERFNGIAELLEILGSIINGFALPLKDEHKLFLIRVLLPLHKVRSISMYHPQLSYCVVQFLEKDPSLTEEVILGLLRFWPKVNSTKEVLFLNEVEEIFEVMEPSEFVKIQVPLFQQLSKAISSQHFQVAERVLYYWNNDYFCNFVNDNVDVILPIIFPALYENSKMHWNRTIHGMIYNTMKMFMEINPTLFDECYNDYTFSQEEAEIKDKERRDMWLALEIMSNSGGKDSYENIEVFSKSLKETRRPLEQSIENLRLDDHKYTQAISIAKPTRINTETDDTRIKLNTKYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7P9E3</accession>
    <name>M7P9E3_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01198</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873114.1">
        <property type="nucleotide sequence ID" value="XM_007874923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P9E3"/>
    <dbReference type="STRING" id="1069680.M7P9E3"/>
    <dbReference type="GeneID" id="19894895"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01198"/>
    <dbReference type="eggNOG" id="KOG3204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076922_0_0_1"/>
    <dbReference type="OMA" id="TRFNKTH"/>
    <dbReference type="OrthoDB" id="1882297at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR10485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="197" mass="22916" checksum="603DE76EBF84E623" modified="2013-05-29" version="1">MLFQKEPIVVDGKGHLLGRLASVVAKQLLNGQKIVIVRCEEINISGEFFRNKLKMHAFLRKRTRFNATRGPFHFRAPSRIMYRAIRGMIPHKMARGSSALERLKVFEGIPPPYDKKKRMVVPEALRVLRLKPGRKFCTVGRLSKEIGWKYENIISKLEEKRKIRSHAYYTTKVAKEKKFLEAKKNVSTSKILEEFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAN1</accession>
    <name>M7PAN1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873019.1">
        <property type="nucleotide sequence ID" value="XM_007874828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PAN1"/>
    <dbReference type="STRING" id="1069680.M7PAN1"/>
    <dbReference type="GeneID" id="19897293"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03606"/>
    <dbReference type="eggNOG" id="ENOG502SA77">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_472639_0_0_1"/>
    <dbReference type="OMA" id="MRDLWMR"/>
    <dbReference type="OrthoDB" id="629492at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="143"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="556" mass="64757" checksum="A930F8A67D8E5017" modified="2013-05-29" version="1">MLSIRLIKLYVSKVKIYYEVLKLYIKAKRFYLFGSYQFYTKLRRNKTMALLDNRTSVLEKIEKYESALKDSYMMIRSYPRNIEGYLRAGKILQLMNKHIKAIYIYKLGIKCLSHDLKKKNLLKKLFFSTLKNIKKNKSLVLQFDIFRKFPMEIILNIFYYLSFKTISLCLRVSRNWRQMILSLDYLFYNLDFSFAKKTVSSKIILLNIKRSHNLVQKIVLNHKCVINDSVITYMSRFCKKLTHLTLTKGFDSNLFLCSFSAFSSLLSLVFLCEIELSFIAQVMSNAPDSLQKIEARKLLVNFIPRWGQKITYIKIIKLIRVDISFCSNKLRIFDISDMLRIIPKATQIFLNNWIEILVLDSYGFSHLDKLDVLDLSGSRLSRIPLMPKCLLNLNLSYLLETDLSFSSLNFECLRCLNLSYSPRLYSDTVITLIGYSGSSLKELFLDYCPLIDRHCIINIVSSCKFIDKLSLSGNSWVDDSLLAIIISELKVLKYIDLSNCLHVSGSSIVELVKTHLSSIIRIRLNGCYNVSLDAVTWIRQLGINIDYSFENNYAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7PBH8</accession>
    <name>M7PBH8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_00824</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OST3/OST6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872731.1">
        <property type="nucleotide sequence ID" value="XM_007874540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PBH8"/>
    <dbReference type="STRING" id="1069680.M7PBH8"/>
    <dbReference type="GeneID" id="19894522"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00824"/>
    <dbReference type="eggNOG" id="KOG2603">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052855_1_2_1"/>
    <dbReference type="OMA" id="VLFGMYS"/>
    <dbReference type="OrthoDB" id="67566at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021149">
        <property type="entry name" value="OligosaccharylTrfase_OST3/OST6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692:SF0">
        <property type="entry name" value="GH11935P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04756">
        <property type="entry name" value="OST3_OST6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004083046" description="Thioredoxin domain-containing protein" evidence="10">
        <location>
            <begin position="21"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR11235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="37497" checksum="B0703D23AB800484" modified="2013-05-29" version="1">MRINLQKLYLILAFLSYVFSTQDLVLDFLKRAESNNGIIQLDGTSIYSILTKPRNYSIVVMFTTNSIEYNCYVCKKLYPSFRLIAKSRHKTHPKSKTLFFGVLEYLENANIFAQLQLTKIPTIIVYPATVGPAALKNSKPLMLNIRDGDISSEWLAQAISQKINEPIHIVQFLNYGKIVFYSFIAFLSLLFFKITHSFIFYIMSRKELWLIFSLACILIFNSGYMLVKIRKSPFNGQDDNSPSYILRSSHAQYGIESHIIVVTYLILMFTVILLTVFTPKIANKRKQTALIILLIIFQFVIFSFLLHIFRMKNRNYPFKLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7PC66</accession>
    <name>M7PC66_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartyl aminopeptidase</fullName>
            <ecNumber evidence="4">3.4.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_03509</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.</text>
            <dbReference type="EC" id="3.4.11.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase M18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.21" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875601.1">
        <property type="nucleotide sequence ID" value="XM_007877410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PC66"/>
    <dbReference type="STRING" id="1069680.M7PC66"/>
    <dbReference type="GeneID" id="19897196"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03509"/>
    <dbReference type="eggNOG" id="KOG2596">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019532_2_0_1"/>
    <dbReference type="OMA" id="GPILKVN"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.250.10:FF:000001">
        <property type="entry name" value="Aspartyl aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002759">
        <property type="entry name" value="PRK02813.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF3">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 11" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR08069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="484" mass="54121" checksum="F6CEDD6D8E702E82" modified="2013-05-29" version="1">MTCQIYKNLHDNMQPKVVTDHSYAYGFLKFLHSSPTPYHVVNSIRNILISAGFKELKERDPFEEHVEPGKMYFITRNTSSLIAFSIGKEWRPGGPIALAGAHTDSPTLRIKPISKKISEEYLQVGVETYGGGIWHTWFDRDLGIAGRVMVAEANGLLKQYLVDIDSPVLRIPSLAIHLDREVNQKLEFDKEAQLLPILGENSPHEDSKSEGVLLDELSRHHKDLLTLIAQKLSINIHQIRDFEIILKDTQPPCFGGVNKEYIFSGKLDDQDMCFCILHGFLESFQCKTLVNSDTSIKMISFFDHEEIGSISAHGAQSTFLPLILRRLFNTPIAKKYGNSSSFEQSIARSLLVSADMSHAVHPNYASKHESMHKPKINKGLVLKINANQRYATDAPGILILREVAKKVQANLQLFVTSNSIPSGSTIGPGLSASLGIRTIDVGNPQLSMHSIREMAGTADINNAILFFRSYFENYACIQKQVMVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7PDD0</accession>
    <name>M7PDD0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4</fullName>
            <ecNumber evidence="6">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Carbon catabolite repressor protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Cytoplasmic deadenylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Glucose-repressible alcohol dehydrogenase transcriptional effector</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">PNEG_03292</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">Acts as a catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="6"/>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875367.1">
        <property type="nucleotide sequence ID" value="XM_007877176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PDD0"/>
    <dbReference type="STRING" id="1069680.M7PDD0"/>
    <dbReference type="GeneID" id="19896979"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03292"/>
    <dbReference type="eggNOG" id="KOG0620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016428_4_0_1"/>
    <dbReference type="OMA" id="PHYYARA"/>
    <dbReference type="OrthoDB" id="428734at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007089">
        <property type="term" value="P:traversing start control point of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09097">
        <property type="entry name" value="Deadenylase_CCR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000037">
        <property type="entry name" value="Glucose-repressible alcohol dehydrogenase transcriptional effector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000447">
        <property type="entry name" value="Glucose-repressible alcohol dehydrogenase transcriptional effector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF100">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="25">
        <location>
            <begin position="362"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="116"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00030493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00031469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00033317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00045495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EMR08464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="718" mass="81849" checksum="B10A463A7F216714" modified="2013-05-29" version="1">MADNGSNVINNYQQYSSLPQRLFQPRHTHESPSKNDISSQSYPSTPSHTSNLSYNLTNSAHHDLYSSTQRYSSQINISKFQQTQEHLNSANGLNSQHTFTSRNPINISNNNNSLTFDASSANSPHWQQQLSYAKISRQSSSPHHHARTAATTTHNVSSNSGITDTNNLNKASADGIHRKDGPPVEKQDVQRDNGGKIKRQDWTNLDMGGMGLRNISQELFRYTFLTSLYINHNKLLRIPSDIGRLRLLTQLDVSGNNLTNLPPEIGMLTNLKELLFFDNQITNIPPEFGTLYQLETLGLEGNPLPDAFKSLLAKDGTKSLIYYLRDSCPVPLPPPEREWITFPGKKSENSSLENETFTVFNYNILCDRCATVIMYGYTPSWALSWDYRKELILHEVLSYNADIVCLQEVDVDNFEEYFSPKLSIKGYKGIFWPKSRAKTMNEAERRIVDGCATFFKTNIFDLLEKQLIEFNQAPLRRDGHKLTHDMYNRVMTKDNICVVSLLEHRNAGYRLIIANTHFYWDPKFRDVKVIQATMLMDELTEMAENYAKIPVRKRPSKILDDTFDFNWNENRPTYSSGTKIPLIICGDFNSIPGSGVYDFLSRGHILENHSDFMDSKYGTYTTDGRSHSFQLKSSYNIIGELPFTNYTPGFSGVIDYIWHTTNSLEVTGLLQEVDKQYLDGVVGFPNAHFPSDHISILAEFKVKKEKNQLPPPDFGSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M7PED0</accession>
    <name>M7PED0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome assembly chaperone 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875024.1">
        <property type="nucleotide sequence ID" value="XM_007876833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PED0"/>
    <dbReference type="GeneID" id="19896664"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02977"/>
    <dbReference type="HOGENOM" id="CLU_1116136_0_0_1"/>
    <dbReference type="OrthoDB" id="5347372at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="28040" checksum="47BFEDC28731F3DF" modified="2013-05-29" version="1">MNFYEDPPKRYSLDNSETSSDEDLGENNFFKKDKIKKNISSCIIESVNSFPNDIKNVIIASELFLDILKIFPGENTSEVLFKFTGNKSIALFSNSNLSLYSIIFPNNIPPEMCYHLSSYIFDHLKFKRIFLLATIFQWAVFSPVSFLRTTSSSFQIENELCPLLKPPALLFGMEASILSLCEQRNLDAIAIIASSNGPSAHLQISTDIAEQVANILDQLIGNGNFGLKTALCNYNAYIKKRTNILSMYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7PEN7</accession>
    <name>M7PEN7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874735.1">
        <property type="nucleotide sequence ID" value="XM_007876544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PEN7"/>
    <dbReference type="GeneID" id="19896401"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02710"/>
    <dbReference type="HOGENOM" id="CLU_742114_0_0_1"/>
    <dbReference type="OrthoDB" id="5402089at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="6">
        <location>
            <begin position="239"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="373" mass="42720" checksum="A9286818EDF9DD71" modified="2013-05-29" version="1">MLCDLYKNAFIRFKAQELLFCISLLSIKANKPFVFKIKKRISSTFLKNIKISLLFIFLCFSTGLAYKSEKESNNNKHDGSLSLDTGFYAKQNTYDSIQADISNNYGIEDDDFSDDYTEEESFKKDFDINTYGKTEEGDFKKYFQSFEGSYIPPYVKRAIINSLKPIMQISSRHLAEKKKPLDYFIKFFKRSFTASSSKLQKKSTRNSIYKRSFLHLSKRDQVQCVNFLEKLEDSSLNKKARECFKESIFFSGCPNIFDIPCLCRSNSYKSHIALCIYQKSTVQLINAFAFASEICSSYESLPSSCISSLMADSSNIYKKYNFKDKIDTSKESSSSKEECSKSYSIFTNFSILTLIFIVAGAGIFVQTGILSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7PFF3</accession>
    <name>M7PFF3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Iron hydrogenase large subunit C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02528</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NARF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874538.1">
        <property type="nucleotide sequence ID" value="XM_007876347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PFF3"/>
    <dbReference type="STRING" id="1069680.M7PFF3"/>
    <dbReference type="GeneID" id="19896220"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02528"/>
    <dbReference type="eggNOG" id="KOG2439">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018240_0_0_1"/>
    <dbReference type="OMA" id="VMPCTCK"/>
    <dbReference type="OrthoDB" id="10253113at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.950.10">
        <property type="entry name" value="Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050340">
        <property type="entry name" value="Cytosolic_Fe-S_CAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11615">
        <property type="entry name" value="NITRATE, FORMATE, IRON DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="Fe-only hydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron hydrogenase large subunit C-terminal" evidence="4">
        <location>
            <begin position="104"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="482" mass="54838" checksum="7C699DEEF70EB851" modified="2013-05-29" version="1">MSKILSAEYLNDFISPSQTCIKPIDIIGNTSKNNHIKIDKEGYYELDNDGIKKKLEPVSITLSDCLSCSGCITSAESVFIKTQSSQKINEVIKENIGLVENEQKILIASISSQSRASIAAAFNLSIKSTHARLTYFFTKILPFSHFIDTNFGRELALNELSNEFIRRYKAREKGCKNQLPLLTSACPGWICYAEKTHREILPYISHVKSPQQIMGSIVKSKVEKSSGKHRQYIYYVSIMPCFDKKLEASRDEFSENGIRDVDCVITTTEVIEMLKERSLDLRQIPEASHDLLFSDYINSDIIEHPGSSSGGYLAHILSFSSQELFNTDNTNTNIEHNITMNIIRNNDMKEYIIKGPNGIVLRMATCYGFRNIQNLIRKLKTKNRISQEAGYDFVEIMACPSGCINGGGQLKPEIIGLSKTFTHKEWVDYVNELYDSSIKKPVNSFHISQYIKNWGSEFTSKSLYTTYRSIQQNFTKKINQEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7PFL7</accession>
    <name>M7PFL7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rab proteins geranylgeranyltransferase component A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rab GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874598.1">
        <property type="nucleotide sequence ID" value="XM_007876407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PFL7"/>
    <dbReference type="STRING" id="1069680.M7PFL7"/>
    <dbReference type="GeneID" id="19896275"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02583"/>
    <dbReference type="eggNOG" id="KOG1439">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_589409_0_0_1"/>
    <dbReference type="OMA" id="HQYLEFQ"/>
    <dbReference type="OrthoDB" id="1923006at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF4">
        <property type="entry name" value="CHM, RAB ESCORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="53302" checksum="CE63381AD5CB83E8" modified="2013-05-29" version="1">MENNEQYDYIVYGTGLTESILVCACSVKNTVLNVDINPYYGKDYGSLRWDELKKWAKELKSNTVYYDSELIINNEEAMEKPKMYYFSLTPSLIYCKSKIIDLIISFNLQLYLHFKSFESSLIYDELYENGFSEILYTKEMLAFNKNVDFIWKRRVMRFIEFIYDITSEKSQEILKGHDDDLFVDFISSEPFSLPTLYTNMFVYGIALSYLPNITVKEALPKIRQFFLSLGVFIKFAILNCSFGGGSELIQALSRNAALKGATFVLKKRITSYNIDDKEEYPVTVTFDDNQKIKCKKLITSYQIGNYQPNTIILDEIPLLRSICLVKGDLSRILKKNTSIICSFPPHSLKSNEYPVQVIIDGSATGNCPNGQYIIYASTLTATKEKISILSAIQAILRVASINTSTSPEIIFTLTYFQHPIRTEPLYSQHLIPVQGISFNIDFNQDINHASDIYRFLFNQDLSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7PGB6</accession>
    <name>M7PGB6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Golgi SNAP receptor complex member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_02083</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOSR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874062.1">
        <property type="nucleotide sequence ID" value="XM_007875871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PGB6"/>
    <dbReference type="STRING" id="1069680.M7PGB6"/>
    <dbReference type="GeneID" id="19895777"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02083"/>
    <dbReference type="eggNOG" id="KOG3208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078034_1_0_1"/>
    <dbReference type="OMA" id="YLEARIM"/>
    <dbReference type="OrthoDB" id="422156at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048219">
        <property type="term" value="P:inter-Golgi cisterna vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023601">
        <property type="entry name" value="Golgi_SNAP_su1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094:SF2">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094">
        <property type="entry name" value="GOS-28 SNARE- RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR09494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="25585" checksum="2190CA23EDC949A0" modified="2013-05-29" version="1">MLNETKSWSTLRLQLISLESQTESLLLELVTSSETLEEHAQDLFNKRNVIINSLSSLLDPDYGGDTIKRYHVERHIEILEKHKEEYEKMNVSLEIDYYFFHSFRKRENQIIKKLIILKIILKNNESDYFLEESNRIDNSHNMTDEILLQAYTTRDDFYHQKDMLHDMNQRMLRATNFISGIKYFISKINTKRKKNNLILSFVISACIIMTYFMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7PGE3</accession>
    <name>M7PGE3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874092.1">
        <property type="nucleotide sequence ID" value="XM_007875901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PGE3"/>
    <dbReference type="STRING" id="1069680.M7PGE3"/>
    <dbReference type="GeneID" id="19895804"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02110"/>
    <dbReference type="eggNOG" id="ENOG502QRUI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1300162_0_0_1"/>
    <dbReference type="OrthoDB" id="360689at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047865">
        <property type="entry name" value="Ribosomal_uL10_bac_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR09524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="24566" checksum="934F0B290EF2D735" modified="2013-05-29" version="1">MNFHPILNFKGFCSKKITPKEKKAFIQTIYLELIKLHPTFLLIQQNNVSAEAWKYIRRKLYGLGANIKVLRIRLFIRALQAAFKDLESKSLNKDASLQSKIEDLKALKEMVVGPIAIITFSSCIEPSFLKRVIYLIDTSNGQFLLLCGFFEGKFVNTKELLYIKEIPDRSVLHTQLIYSLMFKSNELIQTLEYSSEVLTLILLKNNNYKHIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7PGG7</accession>
    <name>M7PGG7_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HMG-box protein STE11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02134</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874116.1">
        <property type="nucleotide sequence ID" value="XM_007875925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PGG7"/>
    <dbReference type="STRING" id="1069680.M7PGG7"/>
    <dbReference type="GeneID" id="19895827"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02134"/>
    <dbReference type="eggNOG" id="KOG0528">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_497921_0_0_1"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051356">
        <property type="entry name" value="SOX/SOX-like_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789:SF2">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="207"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="207"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="150"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="258"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="547" mass="62359" checksum="E0F37DAD3A80648E" modified="2013-05-29" version="1">MLGKNIESDWLGYWGKDHSMALNTFSKMSIEKEGVLNQKDFFMPFDGLAEELMEHNTEIPEVLGQDMLNDRINSVKESQEITYEEPQSSFYRLMPGLNIDLSVPTFPVSSELPVRLSSPIQLNLSTSMPNPTIEQLHSKKKNYVSQNTVNMVGSLSGSPPTDCYSHGENSNARRSLTTRALSLSPVSSDTAAKKKSPSRSGSSSSGIKRPLNSFMLYRRDKQSSIPTNNHQSISRIIGEMWKRETIEEKERYAEMAQRERERHAKEYPDYKFLPRKKKDKNTSGKSPRRRKTFDPALEQDESNILRMMLNQISHKKSQSEAEKFKLDQYSWLLSDEDNHELQKRTFDIACQTNTNTNHSQTGLVHASQHSEISFMPNIYTTPNSVPLPIFPIKNKIEKIDTNNSLDGYLHTFDNLGDYEFRSLMNNYSTPSVNDSRLSTSFNKSCTESPQSITIYDDIKNLDIFSEKKETPNVSLIPTYDSAIFQDDTGHGYDNFVGIWDDAVEFSSFSFLPFDNHRVLGHSSFELLNSGLVSPLNTSKLGDKCRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>M7PGJ1</accession>
    <name>M7PGJ1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_02165</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874146.1">
        <property type="nucleotide sequence ID" value="XM_007875955.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7PGJ1"/>
    <dbReference type="GeneID" id="19895858"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02165"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_27_1_1"/>
    <dbReference type="OMA" id="ACAQWFH"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18606">
        <property type="entry name" value="ABC_6TM_YOR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="815"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="855"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="934"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="959"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1042"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="129"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="534"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="824"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1135"/>
            <end position="1378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR09579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1385" mass="159240" checksum="E66AA753584269D7" modified="2013-05-29" version="1">MENLNNKENKENINSKCIELEKTKKNSCIQSIKTKLKDIILGPAPSSTKVIPEAHANIISKLLWSWLDHLMVLGFKRPLEISDLWFIDEKRTSKKLGDELLKHYEKHKQKKQGLLLALNDTFRNHYWSATIIKFFCDLLVILSSLMVKYIIIFSQKRALHDQNTHINPKQHVVYGIMLCLVLYLFQTISSFCLHHSFYRTMTVGALSRTALVSCIYRKSLLLKNKQRLFYNNGKIMNLINTDVTNVDISLGYTHIIWTATVQILLIFLILYINLGVPALLGLSLLLISAPILAKVSKTFINKNLRISSIADIRARITNETLQSIKIIKFYAWENFFLDKILNLRKNEEKVIKLLIAIRSLVDSLFMTLPFFCIILAFITYYLIKKNLDPAIIFSSLTLLNHLRISFMLLPFAMGVTSNMLASLKRIQTMLSNEDDFENSDSVKEFRNTLAYQKPENSQEEECNDAIIIKNGYFTWASGSLGQDLEKKELKYSENTFFKKKSSLNQSNLEKKDKKKTKNEKLNEKEKKYISDIVLQEKDKIQNNSEKSFEKNNIEIDLKNINLRIKKGELVCIVGPIGSGKSTLLLSIINEVYIINGTIKLNGTISYCSQISWIQNTTIIDNILFGKPYDEQRYQEVIEACCLELDFQILPNGDLTEIGEKGVTISGGQKQRINIARAVYFGADIVLLDDPLSSVDSHVSKDIFEKCILGLLKDKTVILVTHKLDILDKADKIIYLEDGEIREIGKYSDMISKQEHFYEFVKKFLNTQVESDEYSKKAPETVISGEKERKIKTLMQDEEREIGSIKFKVYIEYIKAAAGLWIIPAVILLLSIYQFFNIGNNLWLSFWIKNQFKRSAKFYMLIYVLLGIIEIILYFIIEISLFNIGRRASTKMHYKAIHRVLRLPMSFFDTTPLGRIINRFTKDIRILDIALSDSYLMFLVTLSFIISIFILIIILLHYFFIALICLMSLFFILMSFYRASSREIKRLDSLQKSNLYSQISETLTGLPIIRAYEKQSKFKLENEKRLDLSNSAYLLVFAAQRWLALRLDAIGNMITLSITILSIISNIDPTTAGLILSYSLQIVGIMSWMLRQFSEFEINMNSVERLHHYGENLKTEAPLIIPEKRPPPDWPQNGEIIFNNVWLKYREELPYSLKNLNIHISKGEKVGIVGRTGAGKSSIIVALYRLVEISKGSITIDGISISDIGLHDLRSKLSIIPQEPTLFEGTIRSNLDPFQQYSDQEIWDSLKKSWFLDSIKKYRNTGSEELSEFNLEWPIETDGQNFSHGQRQLLTMARALLRKSKIVVFDEATSSIDAKTDMEIQHTILTHFKDATLLCIANRINTVIHYDTIIVISSGTLIEFGSPRELFNKKDGVFRSMCIHAGITDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7PH79</accession>
    <name>M7PH79_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01977</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873955.1">
        <property type="nucleotide sequence ID" value="XM_007875764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PH79"/>
    <dbReference type="STRING" id="1069680.M7PH79"/>
    <dbReference type="GeneID" id="19895671"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01977"/>
    <dbReference type="eggNOG" id="KOG3197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NDYENNA"/>
    <dbReference type="OrthoDB" id="10254258at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845:SF13">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR09794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="155" mass="18223" checksum="6A139093128B9975" modified="2013-05-29" version="1">MYRMSIISMLCTELSINRDNFYRCIKMALIHDLAECIVGDITPFDKISPEEKHQRELDAMITLTSKILPKTRSQAAKEMIDLFLEYEEGKTPEALFVKDIDKFELLVQMVEYEKRTKKNLQQFLCVVPKIGNSLILEWVNDVLKEREEFWASINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7PIF8</accession>
    <name>M7PIF8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2Fe-2S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adrenodoxin/putidaredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873449.1">
        <property type="nucleotide sequence ID" value="XM_007875258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PIF8"/>
    <dbReference type="STRING" id="1069680.M7PIF8"/>
    <dbReference type="GeneID" id="19895205"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01510"/>
    <dbReference type="eggNOG" id="KOG3309">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082632_5_0_1"/>
    <dbReference type="OMA" id="TPMEEDM"/>
    <dbReference type="OrthoDB" id="268593at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018298">
        <property type="entry name" value="Adrenodoxin_Fe-S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426:SF65">
        <property type="entry name" value="FERREDOXIN-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="FERREDOXIN/ADRENODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00814">
        <property type="entry name" value="ADX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="7">
        <location>
            <begin position="19"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="128" mass="14525" checksum="DC947F55081C83FB" modified="2013-05-29" version="1">MNRIFFYRKFTCSVSRKKIECTFITPFGERKTLKVCEGSSVLDIAHEHNIDLEGACEGSIACSTCHVIVDPKYYSKMEEQSEKELDMLDLAFGLTETSRLGCQIIMNKSLDGITFIIPAATRNIQFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7PIL3</accession>
    <name>M7PIL3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="5">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_01539</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the TOP6A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="5"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873484.1">
        <property type="nucleotide sequence ID" value="XM_007875293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PIL3"/>
    <dbReference type="STRING" id="1069680.M7PIL3"/>
    <dbReference type="GeneID" id="19895234"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01539"/>
    <dbReference type="eggNOG" id="KOG2795">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037229_0_1_1"/>
    <dbReference type="OMA" id="IETAGMF"/>
    <dbReference type="OrthoDB" id="5377392at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000706">
        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013048">
        <property type="entry name" value="Meiotic_Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848:SF0">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21180">
        <property type="entry name" value="TOP6A-Spo11_Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01551">
        <property type="entry name" value="SPO11HOMOLOG"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52041">
        <property type="entry name" value="TOPO_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Spo11/DNA topoisomerase VI subunit A N-terminal" evidence="13">
        <location>
            <begin position="105"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="14">
        <location>
            <begin position="214"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="12">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR10274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="398" mass="46129" checksum="326CC754E1A325B9" modified="2013-05-29" version="1">MGELLSGESPEESGIVKYIDLSDNMTEENLYIDTVPQTREWVILRIEKLIETTINSIYNKKPLLIKLSMRNNKCIFDRQSNMIKRNSVVKQRVFRFPSKTQIGSWRFAVLIRVLDLIHESLVSNTPVTKRNIYYRDINLFKNSRIVNKIIEDIAYTFKIRRSALNVLATAKGLVCGHIKIKRKNFEEINCLQDSEVLIPSETEIESIETEADWILIVEKESTFRTLVISKFYDHPIAGKGVIITAKGYPDISTREFLYMISKSISTSPSPYKRSTPILCLVDYDPHGINILATYKFGSYAEAHNSHLMAIPSIKWIGVHSNDFHKNQENGYIPMNNKDIKKAFDLLQKEWIQEHINLKNELCRMIFTRVKAEIQLLSENDERCLTEYLADKISKGEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M7PIS3</accession>
    <name>M7PIS3_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873558.1">
        <property type="nucleotide sequence ID" value="XM_007875367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PIS3"/>
    <dbReference type="STRING" id="1069680.M7PIS3"/>
    <dbReference type="GeneID" id="19895296"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01601"/>
    <dbReference type="HOGENOM" id="CLU_338341_0_0_1"/>
    <dbReference type="OrthoDB" id="5382953at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="841" mass="98730" checksum="2CBC0E77548712EF" modified="2013-05-29" version="1">MREDQAFKPLKPETINDLPQCELAYVYITRHVYPRLKIDEKDEPEDIFDAIEKGPFVVTGVIRIIKDEQSQYRHNLEKVVFIKLMNVYLYKIERLSNNSLLIWIIGQRALYVIQSVCDEYKETYNIVTEKADLYSDLRTIRESETKECKFTFHEYLEQISYVWEEEKSEIKDKVIKYSKFLFFMMLDDTLLDWPKSLFFKDLVELCSDSFELAKLNKKRVEILRNNAIDILGLTNGFSDTSMENHDQKLNNFQLQNNFFNINFSLRKLQNNILTYPFPRTNAEGRKLYNDLKKALMHVSFKPKNLDIDMAAVFLGDDLNSVDDIKEKIKSHAEGLIDLIKMSKKWEKSNLFKQLNNITKGIDMPLKKTKSMLLKNENQKKLLYNRRNRIIYDIPFKKIDKEISLFHLIDNSSSEGDNNTTFQTNIHPKKEFLQKIMNLLVSELIDSQKYAKRYNLKIFIHNVTNIFKISYKTILKFILENIECIIGLITQKHTEIYKDLENMLIFKSEFLNNFKTKSLNNRKKKDSSCSYNLLKSNILDSIEDLSFKNKNESSEKSITTDNTYESLDAKASLESNTISTENKISNSLNNLYESSNIELNIQKFNNALINLRKTEKRLKNAISHNFSKSPFNTNSIFNDKKENEEKIYHNNPRPDIMSISSSDINLRDKPLSDNIINTPNNETKSYDLDKISSKSLISSKKNIINSSNSNKNHDKSIYFNKKNKSNDPVINDNSTFNQFTKSLFEFNLIEPGRGKPMLQIIQLPSTQPSQNSKLWFCPFKNCNYFSETLVPNKYFKAIIKHLKYHKDSFSSKHKHKNFNQSQNNMVRDFVEKLETIAESWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJE9</accession>
    <name>M7PJE9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein RER1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01294</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RER1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873218.1">
        <property type="nucleotide sequence ID" value="XM_007875027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJE9"/>
    <dbReference type="STRING" id="1069680.M7PJE9"/>
    <dbReference type="GeneID" id="19894991"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01294"/>
    <dbReference type="eggNOG" id="KOG1688">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074889_1_0_1"/>
    <dbReference type="OMA" id="GWYVVCY"/>
    <dbReference type="OrthoDB" id="448250at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004932">
        <property type="entry name" value="Rer1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743:SF0">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03248">
        <property type="entry name" value="Rer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016013">
        <property type="entry name" value="AtER_Rer1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="189" mass="23050" checksum="502C1BE69030356A" modified="2013-05-29" version="1">MADMENLEFSESFTTMFTIKKNRYAQQFQVLLDRSTPYKAWRWLGSLGLLVLFMIRIFVAQGWYIVCYALWIYLLNLFLAFLTPKLDLSLEQDLQEEDTEVRLPIHQDEEFRPFIRRLPEFKFWYSATRVILMAFICSFIPFFDIPVFWPILLMYFCILFTFTMRRQIKHMIKYRYVPFDIGKKRFSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJP9</accession>
    <name>M7PJP9_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00835</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872744.1">
        <property type="nucleotide sequence ID" value="XM_007874553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJP9"/>
    <dbReference type="STRING" id="1069680.M7PJP9"/>
    <dbReference type="GeneID" id="19894533"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00835"/>
    <dbReference type="eggNOG" id="KOG2539">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_652311_0_0_1"/>
    <dbReference type="OMA" id="PRKHPGI"/>
    <dbReference type="OrthoDB" id="421327at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052571">
        <property type="entry name" value="Mt_RNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184:SF5">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="421" mass="49036" checksum="DDC4B4346B5664D3" modified="2013-05-29" version="1">MFSFFFRNLSFFKGSREFIIRDIMMKCYFSNKSLQDLDRAQQKLYSATVFSNKRVGNVEIPSSIVKSIQDIIENSYKSNIRLSFIKMHPFRGFRKIKDNFSEIEADSYLFYIMPQVYASLYNVINELRLRLGDKWVPETVLDCGEGPGIGALVFQELFSNSIEKVKSIMVLEPIYTMRKRTLYIHKANKTKIISNFSSITKFKFDFIIANHMILDTNVPERIFSNSIRKLWAKVSPENGILLLLERGNPLGYQAIAKARQIILSNSDSNSKKSEVTNVAHVISPCPHDKQCPLYLDGHRFNPKKWCHFGQRLIRPIYLQKIKHFASNIENSKFSYCIIRKEIVRPSLKESKTNLSKDKLFSDPYSWHRLILPPLKKHGHVVMDTCVSDGSIKRMIISKRYGKIHYQNARKAYWGDLWALKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7PKZ3</accession>
    <name>M7PKZ3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_00735</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872636.1">
        <property type="nucleotide sequence ID" value="XM_007874445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PKZ3"/>
    <dbReference type="STRING" id="1069680.M7PKZ3"/>
    <dbReference type="GeneID" id="19894433"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00735"/>
    <dbReference type="eggNOG" id="KOG1620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_368855_0_0_1"/>
    <dbReference type="OMA" id="RVRIGWQ"/>
    <dbReference type="OrthoDB" id="2573163at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF21">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR11139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="755" mass="86835" checksum="44135DB12CDCF980" modified="2013-05-29" version="1">MNDMSCVASGASLITDESFKVMNTIHVPRRSEDLTVIEEVQEKNEEINLEKREKKTNKAPEFQESEDIKVDSELAIDLTVSPVPSGFSLDDVLMTPCIDDYSSTSDDSDDVLETHSFSDYQLEYSPGFVELKPYKHQVGGHHTLFRFSKRAVCKPLVKRENEFYEAVEHLHQDLLAFMPRYMGVLNVTYKDNLHMVSLDKNTFQTSKMEEPSHEQLQKEHTSACIHAVTSLPKVSLEQNMHMLSASIQQNKTSSYPISSHVEGEEGFRPRFPTWGATMIHQNLQEQVLREVFSPREYRQNKSTHRHRIIRQRTQVRHRDDSFEQRNLSDSLTPNTLYDTGPISSLDFDEKYAYLSKRRHSSGNLYEEKDPKGMKGLEGYSLDHSPQLIQSPVMDTNSINIETGDQTTSLQSSSNDIFSMVDLSESLLSKNDSLKNVNSSCDIHKNVSSYTDVGFNWAQRCYELECAKRLKKLQSQQTISVTPLPGDSVHDTLNDSARIERFILIEDLTSGMKRPCVLDLKMGTRQYGVDASEKKRVSQTKKCAMTTSRQLGVRICGMQVWNRKTNAYLFQDKYYGRNLKAEVDFQATLTRFLHDGRTQEEGGGVFYDKIPIVLNKLVKLEKIIRTLKGYRFYASSLLLLYDGGYYESDEEHFTNIKKEPDFDIDIKIVDFSNCIIQENHFSSEIIFPPKHPNTCDYGYIKGLRTLRVYLQKIWEEASEKCFIQCHGNDLSYLNTEHIEIDREKKKNTTDESDVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7PLE9</accession>
    <name>M7PLE9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872161.1">
        <property type="nucleotide sequence ID" value="XM_007873970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PLE9"/>
    <dbReference type="STRING" id="1069680.M7PLE9"/>
    <dbReference type="GeneID" id="19893988"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00290"/>
    <dbReference type="eggNOG" id="KOG2274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NPDQYTI"/>
    <dbReference type="OrthoDB" id="431626at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056840">
        <property type="entry name" value="HEAT_IPO9_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF9">
        <property type="entry name" value="IMPORTIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25018">
        <property type="entry name" value="HEAT_IPO9_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="23"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR11259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="990" mass="113817" checksum="C17F8557B9A297B1" modified="2013-05-29" version="1">MEQKIEQLLSFCQSTDAFIRKQAEDELKILENSGEYPISLINISASSSTETYLRQASLLILKKYVLNHWSPVFQEFYGFIVNQDIKNRIRNLLLELLSSELKVIRNTSAHVISKIAIVDWPDEWPDLLDNILFKLSKDPQIETYGGLKVLKELIDNALTSEHFFSISLCLTRFLYEISINELYSFRTRAQSLSVFKSCLDSLEMIKDIHPEIINSFAIETLDSWMNLFITIISKNIMKTLNYDFILFKLNVIKILYKLHQTFSYLLTRYLPSIFEALWIEIEQVKEIYSEHYILNLYESNEENDSDGELINLPTLLTEELSFIQISLKDKTLQKKMNLEDYSNDSILNKIIDISLFYSQLSLSQEREFIDNSNSFIEDELNENVRYTLRQISADVVEELGNCNLVSTSKILIKKLESMISGLDLGWRYNEAILFLVSRIVENFDISIKRNIVIFSLSFYNIEKPPELLRARAILILGQLSIALNNNELSSVFSNCISMIFSESIGVIKLSAFKTIQRLSVSLSLEYLVPFQLRIIDAIEFYISQVHNESLILLLEVLLLSVKIDRDAILYSKPAIISILFKIILHNLGDPYLIGIIQDIFEDLAKNVSNFSAFCDTILLPLKELFSTKISDASETQLTEVAFDLLCPVIKGGSSSLSIEFLEEIVPGLIYIMKNCDSNEVLQSAEEILRQIILKDYDKLISLKSETGISIFDEIVNILRILLEKSVSESVNFFFGPLVIAIIYRAGERFRDYLPDFLEAIVIRLTYPSSPRFCQELLLIFAHLIINQTKLIVDFLYNIKINGVTGLEILLKSWCENIDIIHGYKNIRTSSVALINLFMLQDQRFSDIVVKGDLIINESDEIITRSKAKLNSEKYFFISFLVKVIKILLKELSTFIEIDDKKSIGTSKADFSNDDDDEWEDDLDSNTYNTYEAYTLSNDDDSIDDPLNELDLQKFLVDFFKNIVSNNINDIKSMASYLTQEECSILASVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7PLZ4</accession>
    <name>M7PLZ4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872390.1">
        <property type="nucleotide sequence ID" value="XM_007874199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PLZ4"/>
    <dbReference type="STRING" id="1069680.M7PLZ4"/>
    <dbReference type="GeneID" id="19894201"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00503"/>
    <dbReference type="eggNOG" id="KOG3519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030277_0_0_1"/>
    <dbReference type="OMA" id="ECDSMAK"/>
    <dbReference type="OrthoDB" id="10256089at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031991">
        <property type="term" value="P:regulation of actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032955">
        <property type="term" value="P:regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051492">
        <property type="entry name" value="Dynamin-Rho_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF20">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="1">
        <location>
            <begin position="41"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="508" mass="60321" checksum="1F14E661CC0874BB" modified="2013-05-29" version="1">MSETSLSFLPITIDSSSTKTMYLHDTFNMEINENEMKMLFKKKKIIIELIVTEENYKNDLFVIEKIYKRKAIEYSVLSQEDMKIIFCNIYDIWQFTNKFSKLLRTAGKNILETNFESNTDLKHSKILFNKLSDTWIGKAFSQMIPQIEKIYSVYCINHDISSERLQKLEKNLSIQKWLEECKKISKEQTNAWDLASLLIKPVQRILKYPLLLIQILDTTSPNHPDIMLLNHANKEITLVIDRINEIKRCKDMVKHVISGRTDNSIRHVIVKGISRKTEKLKQTVGLIETYHDIFYEKLFEEFRRQQIQISTFKRKIKNWFKELTNYLLHQSNLAFAYSNCMITGKKSFSEIQKKWKEYKTLIDKASKDGLCELEKNLAYFVFKPLKLLKNLYKIPNSIIKKRNTKILDYIHVKTLKEKGILPNKVLVQSAEIYNVINTQLKKELPDFLHYTSELFNEIIIRLSYCQQQWYKFWILILKNCLKNYNPLIDFNNISDLFSRKSVTIKTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7PMW9</accession>
    <name>M7PMW9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exosome complex component RRP45</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Ribosomal RNA-processing protein 45</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_00220</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872089.1">
        <property type="nucleotide sequence ID" value="XM_007873898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PMW9"/>
    <dbReference type="STRING" id="1069680.M7PMW9"/>
    <dbReference type="GeneID" id="19893918"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00220"/>
    <dbReference type="eggNOG" id="KOG1614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038194_0_0_1"/>
    <dbReference type="OMA" id="GPQFENG"/>
    <dbReference type="OrthoDB" id="10264038at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11368">
        <property type="entry name" value="RNase_PH_RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000005">
        <property type="entry name" value="Exosome complex component RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033100">
        <property type="entry name" value="Rrp45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF14">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="11">
        <location>
            <begin position="34"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="12">
        <location>
            <begin position="189"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR11794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="286" mass="32938" checksum="899122DED206B0DF" modified="2013-05-29" version="1">MKKDIDMSLNERQFILEALNNNLRLDGRDFDIWRDLSLIFGNNYGQVEISLGKTRIFVCISAEITEPYPDKPYEGIFTIDIELTPIIYSPFESGRSSEETQIISIIDKAIKKSRMLDKESLCIIYGHYCWSIRADVHYLNHDGNLVDATCIAVVAALLHFRKPVVTVKGEEIIIHPIEERVPVPLILTHIPICVTFSFFNKGKILLMDTTLQEERLREEYMIITLNKNKEICQISKPGGITIETSHIFKCLDLALKKTLEITDYLNKKLEENEKLNGYDNEIKNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWU6</accession>
    <name>A0A0W4ZWU6_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_04330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="KTW32854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613334.1">
        <property type="nucleotide sequence ID" value="XM_019757842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWU6"/>
    <dbReference type="GeneID" id="30671603"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04330"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KTW32854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="75" mass="9161" checksum="49F259D3DE6F1A3C" modified="2016-03-16" version="1">MNVMLLIIFYNSKLSLFLKKLVYLIMIAFRKVQNLFFQIKFYLRIYLFNINIVFNEDLVLTCYTFLIDKTFCINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWV7</accession>
    <name>A0A0W4ZWV7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_04338</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="KTW32847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613328.1">
        <property type="nucleotide sequence ID" value="XM_019757850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWV7"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZWV7"/>
    <dbReference type="GeneID" id="19897179"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04338"/>
    <dbReference type="eggNOG" id="KOG1993">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SFHYVFH"/>
    <dbReference type="OrthoDB" id="361693at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="23"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KTW32847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="964" mass="113930" checksum="46D527B88D3C2879" modified="2016-03-16" version="1">MYEAIIQTLYDSVSQDISIVKLAEEKLKSWETIPGFYLSLQDVFMEKVLPDNVRWISIIYLKNGIDRYWRKSAKNSTLSVDEKEKIRKRVLQCSIEENHLLAIFQMIGMNNYKQKNLSLINRPFLFEELSSMIMDSITSKSYTFQQRHLYTLYQIVKNLCASRLVRAKYNLQQITPKLFQLISEIFKNYTDQWIYTVQSNFSESEIFPFLQISHICLKILRRLIIYGFEYPYRNENARFFFQLSYTYLKIYFDLCQYFKEEMSSFLYSHIILFGKMFLKFSSTQSTSIFLMPNSIEIVLTYLNIIEKNADIFTGQDTEYVKFIHKIVMQGLFLIKSSVKFLHNSDILLEFKLGEYKQEIEKAYKILKENLFNSEILQRIFELLITKFMVLKPNDLFAWEEDPEQWLLTEEKQSWEYELRPCAECLFIDIFSIYNNVLSNSLISLLQAVEISFDENTIFLKDAVYNAFGLSICFLPDSVDFNYIFINFLSKDIQVQNSRISKIIYRRILILISQWVSSKSSKNIQSNIYTIFERFLDPYEESNDLVVQFTASMSLKQCLDEWDFEKEQFYPYLKNILDSLLHLINRCKLSDSKLKILEVINIIIERMGQHISPYIQSIVDILPSLWENSEEGHLIKAIIIVTLTKLIKSLREESEKYHPLVIQLIKYSIGSSLNAYIYLMEDSLELWHVLLQETQNSSFQVLSLIPLAITCLDYETGNEFMKFHSLQFLTKLSNLLGESRFDVFYIIIKVLDLTLQTTSINLYSDELIKSGFIFKILESIIINQEPKSITIQYFSLISRICLQDPSIIFDFLAKFSFQQDVLTNEEIINNFLNTWISIFDNIGNPKYRKLNVMGITSLLITNNPYVLINIKPLINIWSETLSEIKENKEGDALIYWNTQDEENDLDTTNNPEMIRRQQLIKQDPIHTTHLETYIHQFFFSCVEKNNGIEQFKINYQIEDISNIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWW5</accession>
    <name>A0A0W4ZWW5_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_04320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="KTW32870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613348.1">
        <property type="nucleotide sequence ID" value="XM_019757834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWW5"/>
    <dbReference type="GeneID" id="30671597"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04320"/>
    <dbReference type="OMA" id="PQPEHYP"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050972">
        <property type="entry name" value="SDr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403:SF14">
        <property type="entry name" value="OS05G0225800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403">
        <property type="entry name" value="TOL-PAL SYSTEM PROTEIN TOLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KTW32870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="122" mass="13886" checksum="EBE055A5E395B310" modified="2016-03-16" version="1" fragment="single">PKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPTPKPTPKPTHKPTHKPKPKPTPKPTPKPTHKPTHKPTHKPTHKPTHKPTHKPTHKPTHKPTHKPTHKPTHKPTHKPTHKPVQFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWW7</accession>
    <name>A0A0W4ZWW7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongator complex protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_04323</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="KTW32863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613342.1">
        <property type="nucleotide sequence ID" value="XM_019757836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWW7"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZWW7"/>
    <dbReference type="GeneID" id="30671599"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04323"/>
    <dbReference type="eggNOG" id="ENOG502SAXJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CISCRPL"/>
    <dbReference type="OrthoDB" id="9995306at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018627">
        <property type="entry name" value="ELP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184:SF6">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09807">
        <property type="entry name" value="ELP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KTW32863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="31902" checksum="BBF6109373233E85" modified="2016-03-16" version="1">MDFSEYFRFNNNNIPPEESVIIVSFTVLVSPAFIIYHFIKTSIENNQRVILVRFLDDFEDLLFASKKWGFDLLSKVLSGNLIYIDGLTKLYGHCLDKWSSKDKNIPKKYVTLTGESNLNGIFSTIMSSIEEVSSPNMKPSLIFWGVDFLVASEILTPSDLLLLVSSLQEMVHYCVITLNSDFAFLSPKKRPSDLEINYSTFAYAIIHRAHSIISLRHFPSGKIKEVTGVIRISRGSGYYTAQKDNFLDISDHEESTNTQLEMLYSVNDSGVRFFHKGTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZWX9</accession>
    <name>A0A0W4ZWX9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Brix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_04318</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BRX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="KTW32875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874591.2">
        <property type="nucleotide sequence ID" value="XM_007876400.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZWX9"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZWX9"/>
    <dbReference type="GeneID" id="19896268"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04318"/>
    <dbReference type="OMA" id="YRHRHLM"/>
    <dbReference type="OrthoDB" id="1638493at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000464">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000465">
        <property type="term" value="P:exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000003">
        <property type="entry name" value="Ribosome biogenesis protein BRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026532">
        <property type="entry name" value="BRX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRX1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="50"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KTW32875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="311" mass="35998" checksum="243B764FA6F062B4" modified="2016-03-16" version="1">MSVYKYQTQKKEKKPLEELLKHSTGIKEDGYCKGFVEKLNDSTGFKKIRQKVLILSSRGTTFRQRHLMKDLADMLPHSKKDTKFDMKSKLYHLNEVAELYNCNNILFFEARKHQDLYIWMAKVPNGPTIKFHVQNVHTMDDLHLTGNCLKGSRPILSFDSSFDAEPHMRLIKELFSHIFGVPKGARGSKPFIDHVVTFSIADNKIWFRNYQIVEKTEGGKKNFQPDVDMSLVEIGPRFVMTAICILEGSFGGPVIYENKEFISPSRIRSLIKREKSSKYKDRQAANIKKFIKKKESMLPKNPLSNSILFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZX51</accession>
    <name>A0A0W4ZX51_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E3 ubiquitin ligase complex SCF subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_04253</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="KTW32947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613414.1">
        <property type="nucleotide sequence ID" value="XM_019757777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZX51"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZX51"/>
    <dbReference type="GeneID" id="19894024"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04253"/>
    <dbReference type="OMA" id="DKYTASM"/>
    <dbReference type="OrthoDB" id="2342932at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043224">
        <property type="term" value="C:nuclear SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017117">
        <property type="term" value="C:single-stranded DNA-dependent ATP-dependent DNA helicase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101026">
        <property type="term" value="P:mitotic nuclear membrane biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045841">
        <property type="term" value="P:negative regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000018">
        <property type="term" value="P:regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000133">
        <property type="entry name" value="Suppressor of kinetochore protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="5">
        <location>
            <begin position="3"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="4">
        <location>
            <begin position="114"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KTW32947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="164" mass="19080" checksum="93DC3972A63B3CFB" modified="2016-03-16" version="1">MSKVTLMSSDNESFIVDKIVAERSILIKNMLEDVGESDLPIPLPNVTSNVLRKVLEWCEHHRGDPLSSTDDDLDLSMHRLKKSTEIDEWDQKFMQVDQEMLFEIILASNYLDIKPLLDIGCKTVANMIKNKTPEEIRKTFNIVNDFTPEEEEIIRKENEWAEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M7NIZ0</accession>
    <name>M7NIZ0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875105.1">
        <property type="nucleotide sequence ID" value="XM_007876914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NIZ0"/>
    <dbReference type="GeneID" id="19896737"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03050"/>
    <dbReference type="HOGENOM" id="CLU_2159491_0_0_1"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="111" mass="13307" checksum="3ED93A5B72F8ABE5" modified="2013-05-29" version="1">MLFNLTILFNNILMNKRFVVVANHDFKLSKYLFCQFYGKKKTYSTLSSINLFIGCLLTGYKILILIRHSFNFFIIFIFKKKQYFYLNAVLYENAFVFLLLLVNSYKYFNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJV5</accession>
    <name>M7NJV5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Replication factor C subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_02685</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the activator 1 large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874709.1">
        <property type="nucleotide sequence ID" value="XM_007876518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJV5"/>
    <dbReference type="STRING" id="1069680.M7NJV5"/>
    <dbReference type="GeneID" id="19896376"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02685"/>
    <dbReference type="eggNOG" id="KOG1968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003574_1_1_1"/>
    <dbReference type="OMA" id="QENYLHY"/>
    <dbReference type="OrthoDB" id="446168at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000021">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000005">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000001">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000395">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013725">
        <property type="entry name" value="DNA_replication_fac_RFC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012178">
        <property type="entry name" value="RFC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF6">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25361">
        <property type="entry name" value="AAA_lid_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08519">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036578">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="12">
        <location>
            <begin position="277"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="915"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="919"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="942"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR08903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="962" mass="108960" checksum="157945720A8EBEB2" modified="2013-05-29" version="1">MTNIRNWLLGEDGRKKSGLKRSKIESVDDLNNDKTKKRVILSDDEEFELVNKKENIKKNVKKQDIQSVEEPCLVPINVSQFFMDKNKILRSSPASKKVVSDEAVQESYINDDDFSFSQSDLLEFEELDKIYKDEINQNSPPKTVDFGNRNDICNIESSLIKKDPIDLKGECTDTSLPVIKDTFSNIKTKESVIISKKKNDTKVKITPKKKSNYTNLITDKQEQNVEDAKNIAQKVLNECPLISLSDLENVESKGVEFYDHTTHVPLVTNASKEIPIGRINCLSGLTFVFTGILKTIDREEGCNLVKRYGGKVTTAPSSKTSFVVLGTDAGPKKIEVIKKNKLKTINEDGLFYLIKNMPALGGDTKAAQLVQKKREEQNLEAEKMAKLLAPETREMQKIQSCQLWTTKYAPQSLKEICGNKSLVEKLQRWLRDWDQNRIANFKKPGSDGLGFYRAVLISGPPGIGKTTSAHLVAKLEGYDVLEFNASDTRNKKLLEDSLIRIYNNTSLSGFFSTYEEAGKKNKLVLIMDEVDGISTGDYGGIGELNSFIKKTLIPIICICNDRASRKLLPLDRTTFDLKFRRPDVNSLRSRIMSIAYRENLKLEPQAIDQLAEITNGDIRQIINILSSWKITQTFMSIDDGKNAAKAAEKHIIMNPWDIVGKFLSGGIFRHTSKLTLSDKIELYFNDHELSHLMFQENYLKTRPDLLSSITNLKQKNHEHLKLIEKASESISYSDIVDSMIHGPQQHWGLMPMHAVFSCVIPSFYVSGFSTSQYSFTSLLGNLSKTNKLMRYLQSIQAHMSSKITGNCSEVRKFYIPLLFDLLLRRLEIKGQDIIPDIIKLMDEYFLSKEHSEYILELSLGPNNGNLLKIPTQTKASFTKQYNKTIHPIPFCDTFDSVKPGIVYNTPDIEDALETNSYESQERVSDNEDGPEKDKLVIESGKKGKRSSKGTAKKKKNNNFDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NKV2</accession>
    <name>M7NKV2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidyl-prolyl isomerase CWC27</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Peptidyl-prolyl isomerase cwc27</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 9">Rotamase CWC27</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02597</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. CWC27 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874612.1">
        <property type="nucleotide sequence ID" value="XM_007876421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NKV2"/>
    <dbReference type="STRING" id="1069680.M7NKV2"/>
    <dbReference type="GeneID" id="19896289"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02597"/>
    <dbReference type="eggNOG" id="KOG0885">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_14_1_1"/>
    <dbReference type="OrthoDB" id="442970at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01925">
        <property type="entry name" value="cyclophilin_CeCYP16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000007">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CWC27 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF6">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="10">
        <location>
            <begin position="21"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00082698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00083804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="382" mass="43680" checksum="55C44A9B63367118" modified="2013-05-29" version="1">MQVYNQEPYTNGKVRINTTKGEIEIELWGKETPKASRNFIQLCMEGYYNNTIFHRLVSGFIIQGGDPTGTGMGGQSIWDEPFSDEFHSRLRYNRRGLVGMANTSKNDNGSQFFITLAPTPELQGKNTLFGRIVGNSIYNVLRMAELETDKNERPLYPPKILSTDVLLNPFDDIIPRTTEGDRLKCMESFLSSEEGFKSKTKKNKVLLSFQDEETNEEICKLPKFKSSHDIGDDLKLSEQPAIVTSVKRKYDLLDETKDIKIATRDVKDIENETKNLSYPTLYVEKLGKKDSSDSKKTKIEEIQAQIHILKDDIKAIGKKKSKYLGSLEFEKGKLLSYLEKEKERYRVSEKAIVGGKGKSKKGREEEVYRLFSLKLSFYVTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLK7</accession>
    <name>M7NLK7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874115.1">
        <property type="nucleotide sequence ID" value="XM_007875924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLK7"/>
    <dbReference type="STRING" id="1069680.M7NLK7"/>
    <dbReference type="GeneID" id="19895826"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02133"/>
    <dbReference type="eggNOG" id="KOG3063">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031077_0_0_1"/>
    <dbReference type="OMA" id="FKWKFSS"/>
    <dbReference type="OrthoDB" id="3821113at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170071">
        <property type="term" value="C:CROP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030906">
        <property type="term" value="C:retromer, cargo-selective complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140318">
        <property type="term" value="F:protein transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000004">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="36859" checksum="ABDA3CA17F9C7F4C" modified="2013-05-29" version="1">MASLFFKTPVDVDIRLEGEDSRKMVDIKVGKDRKQKAPLYYDGESVKGSVTLRPKDGKRMEHSGIKVQFIGSIEMFFDRGTHYEFLSLVQELAAPGEMRHSQTFDFEFKNVEKQYESYHGINVKLRYFIRVIISRRMPDIVGEKDIWVYSYKMPPENNSSIKMDVGIEDCLHIEFEYSKSRYHLKDVIVGKIYFLLVRLKIKHMELSIIRRETTGSSPNQYNESETVIHFIKKSIKSMFNELKKISRFEIMDGQPVRGETIPIRLFLGGFDLTPTFRDVNKKFSTRYYLSLVLIDEDGRRYFKQSEITLYRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLN3</accession>
    <name>M7NLN3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02159</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874140.1">
        <property type="nucleotide sequence ID" value="XM_007875949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLN3"/>
    <dbReference type="STRING" id="1069680.M7NLN3"/>
    <dbReference type="GeneID" id="19895852"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02159"/>
    <dbReference type="eggNOG" id="KOG1960">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040265_0_0_1"/>
    <dbReference type="OMA" id="EPLYLHI"/>
    <dbReference type="OrthoDB" id="397265at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22385">
        <property type="entry name" value="KH-I_KHDC4_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22386">
        <property type="entry name" value="KH-I_KHDC4_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000037">
        <property type="entry name" value="KH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000051">
        <property type="entry name" value="Putative kh domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047890">
        <property type="entry name" value="KHDC4_KH-I_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047889">
        <property type="entry name" value="KHDC4_KH-I_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031121">
        <property type="entry name" value="RIK/BLOM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744">
        <property type="entry name" value="BLOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744:SF0">
        <property type="entry name" value="KH HOMOLOGY DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23469">
        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="236"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR09573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="426" mass="47504" checksum="104B437A5671FDC3" modified="2013-05-29" version="1">MSSSRHGNRQDPNSPDSRFSRDSTREKESSRRHRHDREEKSSNRRRSASPCTAPTTSVREDNLSSGTHLSDEKRPKNPAAIAAAAAARINAMYSNRTSVPVSSEPQKQPTTAPPAPPAPIIRDPYNQEGDYVKDIEVNDLRNRYILTKGATQKMIKEETGADVTTRGKYYPDKTLATERDPPLYLHVTATTKAGLEAAVKKIEELMSQELPSLVDERRFKRKDDVERDELGRRKWPEERLYIGLEPIRGFHLRASIVGPNGQYVKHVQQETKCRVQIKGIGSGFMEPTTGRESDEPLYLHITGPDPTEVQRAKSLCEDLLKSVKQQYEQFKASPHGQNFPGYTGSNNAYGSASGYQAPTAPIGPPGVSGSYSADPYAAYGGYEAYVQYYQSYYQHYYQQGNSANPAQQTQNSQQTGNYHTIAPPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLS9</accession>
    <name>M7NLS9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874190.1">
        <property type="nucleotide sequence ID" value="XM_007875999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLS9"/>
    <dbReference type="STRING" id="1069680.M7NLS9"/>
    <dbReference type="GeneID" id="19895900"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02207"/>
    <dbReference type="eggNOG" id="KOG1150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070940_1_0_1"/>
    <dbReference type="OMA" id="EIVNKAW"/>
    <dbReference type="OrthoDB" id="342454at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620:SF1">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="34"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="208" mass="24833" checksum="4410A288F0A59FD1" modified="2013-05-29" version="1">MTNVNEIDKILENEDAEYAKDQEIERILNAFRLDAYSVLDLQPGVSTSNIQNAFRKKSLLIHPDKTKNPKAPDAFDRLKKAESELMDPKIRERLDTAFATARRMLIQERKWTLDHPELNTEAFRIEVREKTKSVLIEDELRKRKARQIKMAEEGREKKRLEDEAEERKRKKEYDKAWEENRENRINSWRDFQKVGPQKKKRQKQKVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7NM80</accession>
    <name>M7NM80_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial GTP/GDP carrier protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_01942</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873919.1">
        <property type="nucleotide sequence ID" value="XM_007875728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NM80"/>
    <dbReference type="STRING" id="1069680.M7NM80"/>
    <dbReference type="GeneID" id="19895636"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01942"/>
    <dbReference type="eggNOG" id="KOG0750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053371_0_0_1"/>
    <dbReference type="OMA" id="GQPWFSD"/>
    <dbReference type="OrthoDB" id="409947at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001409">
        <property type="term" value="F:guanine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000010">
        <property type="entry name" value="Probable YHM1 (Mitochondrial carrier)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053042">
        <property type="entry name" value="Mito_GTP/GDP_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974">
        <property type="entry name" value="MITOCHONDRIAL GTP/GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974:SF1">
        <property type="entry name" value="MITOCHONDRIAL GTP_GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="216"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR09758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="34962" checksum="8091CC981A821597" modified="2013-05-29" version="1">MLTTTSIKAPISSYHKESNIARISGSITAGILELVLFHPIDTISKRLMSNQGRITSLSHLSKVIFKKNTSSPLYLKFVSLFPGLEYAAGYKIFQRVYKYSGQPIITDYLSNHYGEEFQRIFGKENTKAMIHATAGSLIGVGEIILLPLDMLKIKHQTNPDAFKGRKLFQIIIEENFKLYRGWGWTAARNAPGSFSLFGGSALAKEHLFGLSDYTKATWLQNFVASIAGAVASLTISAPLDVIKTRIQNRNFDHPGNGLLILQSMIKNEGIFSFFKGLTPKILTVGPKLVFSFTVAQSLTPMFDTFFSTSKKHMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NM85</accession>
    <name>M7NM85_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_03413</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875499.1">
        <property type="nucleotide sequence ID" value="XM_007877308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NM85"/>
    <dbReference type="STRING" id="1069680.M7NM85"/>
    <dbReference type="GeneID" id="19897100"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03413"/>
    <dbReference type="eggNOG" id="ENOG502QQWQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003258_0_0_1"/>
    <dbReference type="OMA" id="MDFTRYR"/>
    <dbReference type="OrthoDB" id="67716at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059141">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056548">
        <property type="entry name" value="HEAT_Nup120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021717">
        <property type="entry name" value="Nucleoporin_Nup160"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11715">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23300">
        <property type="entry name" value="HEAT_Nup120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup120/160 beta-propeller" evidence="4">
        <location>
            <begin position="69"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin nup120-like HEAT repeat" evidence="5">
        <location>
            <begin position="862"/>
            <end position="1025"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1184" mass="138531" checksum="FFC32ED9F5DD0464" modified="2013-05-29" version="1">MKSENWLKETSLSVDQLIQNQCVYLNVLRIDEDEDEQLDMPVDPESYYSKAFLASQSSLFLRKNGRYVRKILWRVVYGNILELIPVEISNLGVFSGINIYISFPSEIKPYCVVLIDNNEKDEFTIHVLTKVNLFYTLRFTSEHFFRQEMFSNNMINWCHVYRSCYFDIRAPHFFISITPEKVIFSLKDGGLLMFEKNDQNEYSEIPFSDGSYFSSLKGMFLWGISKNDRLSSNLIISMEVSITYSLLFTISLDGKLKVWSIDNGILLKTYNVWNDQKIFDPHPRCLISILEKPTFPGYKFYLLTFSSIIETGFVLWGATHYEMSFSGLVNLNSFVHLYMRLRPPTNNSVWVVLKFHLSNNFLKNETDSKDYNIKSGMIIWVLWKSNTSSIVQFIAIDPFNPSFSSDEWNTLIPMYRFLSKKISPAVTFDTSPYDVSEYWYRQISIPGQFSSVTIKTSLEIYKYKNHLYDYANNSGIDVTFNCLQEMKEVIYKEINTIVTLQRDPYNGLLLFDKHRQELNAEWIRFLRLCTELEELGSEPLDFICDSETNLIYIVKANAIGVINNCTSSEVIYYHSLNKRRDDPRFQKWCSSKGDPIYSYIGNDTTRFDIAQLLLISNKFLDDFSDMQILFVKQVLEEEIRQKHSFSIGDRIWILSERIFCQHIETSKIDDINLIFNDISDPIFAMTILLRCLINDKCFQLGFYMKNKSALSLNITTSSIYQVVYIYYDILLRMLLVLVFVGCYNDNVQKLTGFYQLFDNYLSEFRECCCIRECCSHLLNKTNEMLVLDTIKNRNYDAKVLNKRNIQRLFGLESTLRLFLREFSLFKELKNNDITDPNNNSSSLILGVFKDGYEMSFCISALLFQFKYLLEAMEVVSWISFIPLGIYLKARIFLSCGKLEKSSVLFRRASLGICSSMTQISDTMLNILKDFGFSFTFNDLYLYFIHVADTYYQEALFFYSAEFYEEARKVGLEKLNSTEKEDLYCKMFQTYMAAKMYDNAYLTLLQFQSYDKKCDSLYKLVDAMCEENLSKKLCEYSFLGLSDELDSILHFRAQNMIDVRANPCYHKILYSWRIKQGNFRGAASIMYHRLQKLRNGSLVKSAGNQEQLDIIEGYLALLSALSCVDISNSWILYPDFDSTYHTNKKIKQSSSKNDATKQRQVLDIVTIRKEYIQELKRMQNMLNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NM86</accession>
    <name>M7NM86_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_03153</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875214.1">
        <property type="nucleotide sequence ID" value="XM_007877023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NM86"/>
    <dbReference type="STRING" id="1069680.M7NM86"/>
    <dbReference type="GeneID" id="19896840"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03153"/>
    <dbReference type="eggNOG" id="KOG2744">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_331530_0_0_1"/>
    <dbReference type="OMA" id="INLMMLY"/>
    <dbReference type="OrthoDB" id="1938591at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16871">
        <property type="entry name" value="ARID_Swi1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051232">
        <property type="entry name" value="ARID/SWI1_ChromRemod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033388">
        <property type="entry name" value="BAF250_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964:SF27">
        <property type="entry name" value="HAT-TRICK, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964">
        <property type="entry name" value="RBP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12031">
        <property type="entry name" value="BAF250_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="5">
        <location>
            <begin position="189"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="864" mass="96268" checksum="6CD86A0CFF5F7F11" modified="2013-05-29" version="1">MEEAPLDSAKQFKNDLMYSGWTAPIYEQPQPFPMFLPGQETDVTQAELVYPPFAKAGQTNTKYMQMHRLLPGYGTQSFSGPVESAYVPSSTNIQTSGSINTLPAINMPINNVISGPINTPINSITSFQPAPSTITSPQMSTQSLSVSSTLIQPSFYSPSTCSPSISIQQGISGTQTLSGRVGPIVQTKPSTIDSLMASLIEFMNKRGISINAHPYIGDQQINLAVLYIQVMRLGGSHKVTQANAWGSIAQAFGINLTLIPNAGQQLSECYKNYLAAYEEAWIYNQQLLMKQQAISNKYKHGIVQEKNEEKNTSYNTTNKALLHFQTQHVLPSKSTSQPISQPISHPVSQPVSQSVSQPVSQPISLVPQSIPQSISIPIADNSVPSNSHPTILSSQSTFTQQYKPKKRIVDTYGGFDMELITRMSNDLENLRYRPPALHELGTINIYALIMSIQSRLHSEVNRALDVLTIITGDKRWCLPLLECDELLDSIIEIADEEYQLLIPDVKNADETISISSYEQMVDLYYDEIDDLTINYRPGSQGYGRFRSMEKILCITTILRNLTFAEENQNVMAKNNALLILIEHLIILISKTNILEISYRQRLDLAKDLIILLSNISQDILIDNESTAIAIIRLITAFSPDSNICLNPDKIIFTPYNPTLHPYLPAAIDTLAKLFARSFPNRHTFAKIMIFLSSKQCLRDNIFIRALMLCISPIPISTLTHPIHTCEVRLALLEHCTLAAETIINIFPKEDNLAHSILSSDDSFLDSFVKLACLLSSIGGGQLPNQIHNIESNPFSRFARRTMNILRILIEKAKEEKPPNEPRHIFSTTSKKEQLLGSLLTPHMDGMIIKDLWSLVEGNCAEETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMB3</accession>
    <name>M7NMB3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear rim protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873959.1">
        <property type="nucleotide sequence ID" value="XM_007875768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMB3"/>
    <dbReference type="STRING" id="1069680.M7NMB3"/>
    <dbReference type="GeneID" id="19895674"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01980"/>
    <dbReference type="eggNOG" id="ENOG502S7S0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_748254_0_0_1"/>
    <dbReference type="OMA" id="RANAECE"/>
    <dbReference type="OrthoDB" id="3363151at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043007">
        <property type="term" value="P:maintenance of rDNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018819">
        <property type="entry name" value="Nur1/Mug154"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293:SF1">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10332">
        <property type="entry name" value="DUF2418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="321"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="43558" checksum="5211812A4DC9598D" modified="2013-05-29" version="1">MEGDKKKTSRLIRRSSRKLLCFQIFLEWMEKIYYHHSWFEYDGLGTYLFLILCQILFILSRSLGKQQEHFFLKKEVKFKKKNVLKITTDLQTDIWKKKFHGMCSWISIGLFIWSVFCTILCFGTSRQYCLFAREEEHPPPSTSARRRVLNKEGISGTLRNLIDRFRLVNSKEEKKNSNISEEVWELRVWNPSTLLIRFFCFFNPVNLILLWTNPFSPKNILLATGISIQLYLFHRIYANYVIDKSIIHSEVFHEYSKKFVEPRLFPYKRDVATSTHPELVQIEAHTPQEKPNKIMHQPSVPTSNRIRSLIEEEWHTPCQKPHGGFRGFPISPSKKVQPSPAKGFRPANSWSIGTSGNHLSYTNIKTTKHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMJ1</accession>
    <name>M7NMJ1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SGT1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875239.1">
        <property type="nucleotide sequence ID" value="XM_007877048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMJ1"/>
    <dbReference type="STRING" id="1069680.M7NMJ1"/>
    <dbReference type="GeneID" id="19896863"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03176"/>
    <dbReference type="eggNOG" id="KOG2406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006241_2_0_1"/>
    <dbReference type="OMA" id="TKDYIWQ"/>
    <dbReference type="OrthoDB" id="27237at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010770">
        <property type="entry name" value="Ecd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060:SF0">
        <property type="entry name" value="PROTEIN ECDYSONELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060">
        <property type="entry name" value="SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07093">
        <property type="entry name" value="SGT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="492"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="594" mass="69555" checksum="998561365CA6CFDA" modified="2013-05-29" version="1">MFSDVCEYWIYIVTADLLCHEDQVFHLKEVQEIIKTEFMSWIKEYLWHYEPFRLEIYDIPGPVHLYGKTHFREGNQDEWAIVFLLREITRNIKDIYVRIIDSDGEFLLIESSRKLPRWINEKNSTYRVWMNQGRLLIIPPENEKKKREIKGLTLSEGLFFLRNKPEQLIHDEKVEKEAFRRIKGYPEKIKENLHRTQVIVPRKIAHILHTEPNLISAAIHEFCQRDPISFKVCEKMKYFYPEDMVSVVIKMTKTLYAQLKGQSFEKHPLFDLSGSKYDQNVMGMKITCGFEMLSAKTPKNHFEYSLKSDPEWKIFIKKLNATGYFENEKEGSEKYKSLEKHAEKCFLRSCPSNPPITNDPVLQIFDILKHPLPTDEEIAEWPNTYDSDSFLHVSPEELDELMRLKTEISSDEDNIEEMPKHKPISNKPVKSLIEKFEDFVNNENAGLYGVEVECDSFTDNTTTDSDISFDADEFIKIMKETLDFSDEPMTEIKDEKIQNESLQNEQEEDKLELKDFMNAMDTELLSTTLKDSFSNLPSDTVDSINEQDKIDANMHYNLLKNLYESVNGQQDATGPANTMLKSMHLSLPSTHLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMK9</accession>
    <name>M7NMK9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoporin POM33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_03196</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PER33/POM33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875259.1">
        <property type="nucleotide sequence ID" value="XM_007877068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMK9"/>
    <dbReference type="STRING" id="1069680.M7NMK9"/>
    <dbReference type="GeneID" id="19896883"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03196"/>
    <dbReference type="eggNOG" id="KOG4002">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065417_2_0_1"/>
    <dbReference type="OMA" id="NVQYLIM"/>
    <dbReference type="OrthoDB" id="5581259at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990809">
        <property type="term" value="P:endoplasmic reticulum tubular network membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140480">
        <property type="term" value="P:mitotic spindle pole body insertion into the nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051645">
        <property type="entry name" value="PER33/POM33_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005344">
        <property type="entry name" value="TMEM33/Pom33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03661">
        <property type="entry name" value="TMEM33_Pom33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="32818" checksum="6997E9AC21DD65E3" modified="2013-05-29" version="1">MASHTYIQLPLSRRIKVLVKHPQFVWFIGHSVLLLFSLRYLFSYLTFSSIRHVFSYRCAFLGAILTYSIVVYKTYRKTYTKSKIDLNVILRIWLDENFQYLLLATVWFLSRPVALSLTPYVIFSLFHFLTYLRSNVLPTLNPNALKLDENCIEASICRYIQFLIKQHYDSAMKLVSKVEVILIGTRVLIGAFTFQNSFTVLLFYAFFIRYRYFTSTYTRQTFVHISIYIDHLVADSRVPGSVRNSWVSIKRFIKDYAARSFINAPSDPLTNKESHNKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMP5</accession>
    <name>M7NMP5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar ribonucleoprotein protein MPP10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_03327</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
            <location evidence="1 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the MPP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875404.1">
        <property type="nucleotide sequence ID" value="XM_007877213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMP5"/>
    <dbReference type="STRING" id="1069680.M7NMP5"/>
    <dbReference type="GeneID" id="19897014"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03327"/>
    <dbReference type="eggNOG" id="KOG2600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011271_1_0_1"/>
    <dbReference type="OMA" id="THHEVID"/>
    <dbReference type="OrthoDB" id="445326at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012173">
        <property type="entry name" value="Mpp10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04006">
        <property type="entry name" value="Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017300">
        <property type="entry name" value="snoRNP_Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 7" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="582" mass="68083" checksum="1000792C152A4E86" modified="2013-05-29" version="1">MIEHEMYTQLDVLLHDPKQFLKPSNKLHSTILFQVKKLLDPIIKQNSIFDDLYLNGLDGNQIFEEVRLITNELIDRLLEKLKIILKNQVNLKKKLKYKTKREIDTAKEDVDSPKGLNKEKCQENSIDIIAYKSNILPINDEYISKEDKNIFKEKVLGLNNLPISTNNFNNKIKKLEKIDNLLDEKNNDVYYLSNLSESEVSSEYSDKGFENTNEIKYANFFLPSIKKKSDELSNIQKTPKNQKHNDGNFEKDANIKENHENIMSKVQQDLFANSNEEIKEHKISNKSKYMKTQKILSEEIKKLEMENIAKKDWTLMGEVKAKDRFINSLLEEDIEFERETRPEPVITKQDILNLEEIIKKRIIDSNFNDIQKIYSKKKKTFHPSKLFEIDDEKNKKSLAEIYEDEYNKKTDPNYIGKKDEKLIKEHNEIEELFKKAMNKLNSLSSLYHKPKLAKPTLNIISNVSTIIMEEAQPSSLATNDMLAPHEIYITGSKKVKGEILKRSGIIIAKNEMTREEKNKTRKYLKSRKKHKLLNQTNKLAGEIIKTLKKSNVKIIQANNEKKNIIKHPKSSKEIKRSFELKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN96</accession>
    <name>M7NN96_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873377.1">
        <property type="nucleotide sequence ID" value="XM_007875186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN96"/>
    <dbReference type="STRING" id="1069680.M7NN96"/>
    <dbReference type="GeneID" id="19895134"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01437"/>
    <dbReference type="eggNOG" id="ENOG502QX5C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_804400_0_0_1"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053116">
        <property type="entry name" value="GATA-type_Znf_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47341">
        <property type="entry name" value="GATA-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47341:SF1">
        <property type="entry name" value="GATA-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="2">
        <location>
            <begin position="262"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="345" mass="38931" checksum="269F2DA2976F5E53" modified="2013-05-29" version="1">MCTPDIRVDQSSLRFHTRKQSSPLRSAQTKYNSDMMCDYMDDTDPGVIFKFRFLWPFNRRDVRQLSPTSSISSSSDHSNESVFKSSSYSYSSGSLSCNVSSFPCLLGQIIDHERQKRSKLPSDLFEFEEDTKRASGAIILASKRLQCIVKDNEKRPANTTNNESGRKKLKSPFIYHVSLGVSSAYPDTDLEFWRNNLQKQMSLRHRNSCRVFKKTNKQTITASPKLRSRSVASKTSVIKVPDFQPSPVTPSNSVSNIVGQAATPERRCISCGSSSTPCWRPSWYGNTGLLCNSCGLRYKKIGVRCLNKNCRHIPLRSEFREMKSRVNGNSTIDCIKCGGEVKIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNA7</accession>
    <name>M7NNA7_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874927.1">
        <property type="nucleotide sequence ID" value="XM_007876736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNA7"/>
    <dbReference type="STRING" id="1069680.M7NNA7"/>
    <dbReference type="GeneID" id="19896577"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02890"/>
    <dbReference type="HOGENOM" id="CLU_181953_0_1_1"/>
    <dbReference type="OMA" id="WEGHDDH"/>
    <dbReference type="OrthoDB" id="531564at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044980">
        <property type="entry name" value="NDUFB2_plant/fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36987:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36987">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="58" mass="6781" checksum="75EDEB7CB869BACF" modified="2013-05-29" version="1">MKGTNGIHFHPPPKSYIVISQLLGASMWFFMLYRMKKDGPIILGLKNPWENHESEEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNB1</accession>
    <name>M7NNB1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SUN-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_03082</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Interacts with EMP65.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the SLP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875138.1">
        <property type="nucleotide sequence ID" value="XM_007876947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNB1"/>
    <dbReference type="STRING" id="1069680.M7NNB1"/>
    <dbReference type="GeneID" id="19896769"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03082"/>
    <dbReference type="eggNOG" id="KOG1396">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006633_1_0_1"/>
    <dbReference type="OMA" id="CYITRIF"/>
    <dbReference type="OrthoDB" id="266334at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000099">
        <property type="entry name" value="Uncharacterized protein, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
        <property type="entry name" value="SUN DOMAIN-CONTAINING OSSIFICATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="591"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="12">
        <location>
            <begin position="154"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR08606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="613" mass="72579" checksum="7EC1743A0E453906" modified="2013-05-29" version="1">MSIKAFYLCYITRIFGISFFSLFFLGFLSVYTQHLSLIKDPHWHEFKKAFFLLNNQCFPCEYRDVLEKSFFVSKKEELDVKLKNFEYCSELSFEESKKQAVGEIIDENHEILLEKEHKNNMVHNETLLYDFKERKDQIEDDNDTKKVKDYVFTKEDIPEKFKFYDYLSESLKERFNYASVDCAANVLRANVEAKGISSILSSDNDFYMLNKCSAANKFVIVELCNDILIDTIVLGNLEFFSSTFKDFRVSVSDRYPIKETQWKELGIFTATNIKDVQTFMISNPLIWSKYLRIDFLTHYGDEFYCPVTLLRVHGTTMIEELKYEESELKESVKFNDKTVLEAQDLKQLPNDVLNFNKRSTENHKINFDGEKTHEISPLHTECFINASIVTNLCNDIFVQDINRYRDSDSSFFSSRSKSPYLNGNHYWISAFFIKNPICSSLDNFSSSTFYLNFTEKKIMDNQTTQNTTQSSFYNIENLGMQENIYKTISKRLSFLEMNTSLYLQYIEQQSKMLKNTFIKMEKMQDNKIDFVIQTLNSTVFSRLNILKHQYEELWQNILSKIEYERNKSKKDVDMVASKLEYLSNEILIQRWIIVFQFLILFTIFILFIFKFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNF7</accession>
    <name>M7NNF7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mitochondrial import inner membrane translocase subunit TIM22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_01495</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM22 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873435.1">
        <property type="nucleotide sequence ID" value="XM_007875244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNF7"/>
    <dbReference type="STRING" id="1069680.M7NNF7"/>
    <dbReference type="GeneID" id="19895191"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01495"/>
    <dbReference type="eggNOG" id="KOG3225">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091077_1_0_1"/>
    <dbReference type="OMA" id="VNPNMAD"/>
    <dbReference type="OrthoDB" id="75343at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039175">
        <property type="entry name" value="TIM22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR10223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="164" mass="17984" checksum="AD9DA56212FC1C25" modified="2013-05-29" version="1">MLPYDQDVSHILSEENMEIQQKRIIEAINNIQESCIFKSILSGGTGFVIGSVFGLFMSSISMDISVDHKIYDKSFKEQLKYGFKDMGKRSWLSAKNFATVGAIFSGSECCIESYRAKNDIYNGISAGCFTGGALTIKSGPKAMAIGCLGFSAFSAVIDYYLRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNH1</accession>
    <name>M7NNH1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02947</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
            <location evidence="1 6">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874992.1">
        <property type="nucleotide sequence ID" value="XM_007876801.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNH1"/>
    <dbReference type="STRING" id="1069680.M7NNH1"/>
    <dbReference type="GeneID" id="19896634"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02947"/>
    <dbReference type="eggNOG" id="KOG2065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_473353_0_0_1"/>
    <dbReference type="OMA" id="QLSMWLL"/>
    <dbReference type="OrthoDB" id="78652at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF27">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="3"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="291"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="576" mass="68417" checksum="0495109BE5C2B67E" modified="2013-05-29" version="1">MFHELLILLSSYSSHQLVSIFDSSPWIHPSERILVHSLCKLARQHSFLRQNKRISLELKKSWINIVYMGICEICEPFMKLILEIEEQILSKDSILVGGKDNISLSQIEIMFKPWYRRMDYLEHIVLQIKENCKEEEIMNELEEDMKAGYKDIENIARFLLCLMQKSWVNRMIPWMFWGKIPLNEEFYISVIKEKDLEEYRYDMKKVPKFVSEKAAYDIFTNGKAICKMENVLRDEFFEHSVISDNMNLILTLEYPISLCLFENVIKKIKENCSKSIFKNIISINMITNLIRLLCDYYLIQYSEFAFYFLKEVFNKQKVIKMSKQTQISIILIRTFKELSRFEENLNLDDNIPNRRMLSLLISKDSVHNTSFSDLLIGVPIILSFSIPWPLTLFFSEKDVEKYSDIFSYLIAIKQARTLLSDLWRERRVVANPDRIKRSYWATANYVLYFLDGLWAYFQANVILTEYEKLMSCFSDDFSYDPESIQICHQQFLFSLTKKLFLKNDNFLATLKKILLSVNLIASVINSCFVNNYTVPQQFDENLIRGFIKQIIRIIEEIEHTDVDLRLVNHLLLRMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNJ5</accession>
    <name>M7NNJ5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02984</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875032.1">
        <property type="nucleotide sequence ID" value="XM_007876841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNJ5"/>
    <dbReference type="STRING" id="1069680.M7NNJ5"/>
    <dbReference type="GeneID" id="19896671"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02984"/>
    <dbReference type="eggNOG" id="KOG3313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083737_0_0_1"/>
    <dbReference type="OMA" id="YNWDVAQ"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23156">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000001">
        <property type="entry name" value="Prefoldin subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016655">
        <property type="entry name" value="PFD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016396">
        <property type="entry name" value="Prefoldin_subunit_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="127"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="181" mass="21349" checksum="0A6840072BCD5612" modified="2013-05-29" version="1">MKSKEVSSHRKGIPTAPFVDKIENYVTSQEQVEPTLRQFQKLIAKYRFMEISFQRHTAGLLEKIPEMDKTLQMLRFLESKKENKEPFETYFELDDTLYAKAVIPSTNKADIWLGANVMIEYPIPEAIEFLLSKLASAKESLKQYEEDLEFVRENITTLEVNIARIYNWVYLIYNEKESQHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNQ1</accession>
    <name>M7NNQ1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_01567</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ELP1/IKA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873518.1">
        <property type="nucleotide sequence ID" value="XM_007875327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNQ1"/>
    <dbReference type="STRING" id="1069680.M7NNQ1"/>
    <dbReference type="GeneID" id="19895262"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01567"/>
    <dbReference type="eggNOG" id="KOG1920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001477_0_1_1"/>
    <dbReference type="OMA" id="WRESLYC"/>
    <dbReference type="OrthoDB" id="40048at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056167">
        <property type="entry name" value="A-sol_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056164">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056165">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006849">
        <property type="entry name" value="Elp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056169">
        <property type="entry name" value="HB_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056166">
        <property type="entry name" value="TPR_ELP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23925">
        <property type="entry name" value="A-sol_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04762">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23797">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23936">
        <property type="entry name" value="HB_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23878">
        <property type="entry name" value="TPR_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017233">
        <property type="entry name" value="IKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="ELP1 first N-terminal beta-propeller" evidence="7">
        <location>
            <begin position="1"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 N-terminal second beta-propeller" evidence="8">
        <location>
            <begin position="396"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 alpha-solenoid" evidence="10">
        <location>
            <begin position="680"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 TPR" evidence="9">
        <location>
            <begin position="891"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 three-helical bundle" evidence="11">
        <location>
            <begin position="1062"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1178"/>
            <end position="1224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR10308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1264" mass="145884" checksum="E80E7FF86C544029" modified="2013-05-29" version="1">MRNLYLLKRENIVLHREKEKKRYISDLSFNSNCNSGIIVCSLGEINESILIEEMKNEEKVSVVVKKETLWDLSSFLDLEIVDFQFLSETQTSCIIIKNGDIVLIRNNTSLDEEKAEIVGSVEGGIVAAKWAPDETVLSICTETSRFLLLSQSFETISEITLQKSDINLSNHVSIGWGKSETQFQGKKSKNMPRDPTIPEKVDEGILSPLDDQITRISWRQDGAFVVLSKIESENKRINRVFSRNGALDSVSQPVDYLESPLAWKPSGSVIASIQRKPKELDVIFFERNGLRHGEFSLLPSLLSDERIIDIQWNCDSTLLSILLSNKLQFWCMSNYYWHLKYEIKSNNNKNTSIKWHPKIPLILTLINDGDLIVYNFSWIIISSPLNLPYDYGTIAVVDGNNLKLTPFKIANVPPPLSFKDIKLSGTPTSISISMDSNHILSLIDNMVEIIHWPLNTDLTSSPEIINKLDLTGLLNDYYPRQILYLEENIFTILLDTYNTSKILFFLYNLHKDFKLLDGITFKSKIALASPASNGKSVIAESIKGEVFNLFLKKDHKIDNILLFSLPLFCYCMKNIQYMEEKITFFLSDNGKLFANDHLISNNCTSFICCKEYLIFTTTLHLVKFVKLTSKIEDFIIPSDDTTNKNVRSIEKGAIIISVIPSITALIFQMPRGNIETIYPRVLVLSSVYELIKSKKYDKAFLLCRTHRIDTNVLYDYNPSQFLNNISLFVTQLNSREYLNLFLSTLKEEDLTKTLYNMELTKNDTDPETKVLNTKSSKVNMICDSILKVLETYSDDKYIESILTAHLSKIPVDYDSALKLIIDLKNTDSNNAKKGIKYICVLADVNKLYNHALGLYDLRLTLLIAQNSQKDPKEYLPFLEDLQKQSISRRCFNIDNYLKRYEKALMHLIDIGDEVFDELCDYVVLHNLYKEALKKLQNNFSNYNKILELYAAYLEKNNHFEESALAYEILNNYEYSIIMYKKAGLWRKALTLAMKSKVSEDDLNKLAESLNFIMQDRRKFSDAAEIQIYYLKNLKEGLRLLCKDYNYNKAYELAQYYNSNELIQEVIVPGLIDGFSELNELFSELSCQLKTQVERIRILKKKREQDPYTYFGTNIDDIPDDISLADTNTSITASIFTRYTSYATNTNSFYKKNEKISRKEERKKVRKHKGSIWEEEYLLNSIIRLIDKLEDARNDSEKTIKGLLLERMNEKANILQKQMICLVEDVQKCIKEIFTQKTEDLTENIQNNFKTIPVVRSVNELKILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNT8</accession>
    <name>M7NNT8_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ribosomal RNA large subunit methyltransferase J</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_01611</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873568.1">
        <property type="nucleotide sequence ID" value="XM_007875377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNT8"/>
    <dbReference type="STRING" id="1069680.M7NNT8"/>
    <dbReference type="GeneID" id="19895306"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01611"/>
    <dbReference type="eggNOG" id="KOG1098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QRKDKYY"/>
    <dbReference type="OrthoDB" id="1287559at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000004">
        <property type="entry name" value="AdoMet-dependent rRNA methyltransferase SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03163">
        <property type="entry name" value="RNA_methyltr_E_SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012920">
        <property type="entry name" value="rRNA_MeTfrase_SPB1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024576">
        <property type="entry name" value="rRNA_MeTfrase_Spb1_DUF3381"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028589">
        <property type="entry name" value="SPB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF13">
        <property type="entry name" value="PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11861">
        <property type="entry name" value="DUF3381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07780">
        <property type="entry name" value="Spb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="10">
        <location>
            <begin position="24"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3381" evidence="12">
        <location>
            <begin position="234"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase SPB1-like C-terminal" evidence="11">
        <location>
            <begin position="601"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="500"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR10358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="794" mass="92751" checksum="5650B2F62CC18C63" modified="2013-05-29" version="1">MRKSTAKQRKHGDKWYHLAKEQGYRSRSSFKLIQLNKKYRFLEKTKVLIDLCAAPGGWLQVASKYCMPGSLICGVDLVPIKPIPNVETFVEDITTDKCRKKLQQYLKTWKADTILHDGAPNVGMAWIHDAYSQAELVLKSLKIVTEFLISNGTFITKIFRSKDYNSLLWVLNQLFRKVEATKPLASRDVSAEIFVVCQQYKAPDKIDPKFLDPRFVFEDLPCSVPDHVTRLFNPSKIKRQRDGYEDGNYTQHKTVTAEEFLNSNNPIEILSIASVISLDDRDLENYKGIKNFDITTEEIIQCCKDLKVLGKKDFRGLLKWRTLVREKLGLSEKKETNLQEKVEIIPLNEEEEIEQEMNRLNNQQIMKKKREKRRMLESKKKSILRLHLGMVEPFDIGLEQSETISEDPIFEIPSFKELDKLEVENAEMDLISEDDIDTTEPETEFEDSEDNLDNMEKELNLMYEYYRSKKKEFKSKINGNFNETNNDELNTIEIDDKSEKHSDFDLKDENQSSNFESSSDESEFIDPEEKGELTQKAKLFFDNDIFKIHNNYFENLDNVKTVENRLLKTRKNQSKPSCKIHNDVSNDNIKILNGTTEKNQNILIQKKINKLVDITTAEEMTLARSIASKKKSKKDIIDDSYNKWSFQDNKNLPEWFLDDERKHNRRNLPISKEAAMVIREKLRAMNARPIKKVLEAKARKKMKAMKRLKRIQEKTDLIIQTNDMSEKEKSENIKKLLKKSVKFKNRNKVKIVVAKGLNKGIKGRPKGVKGRYKFVDSRMKKELRAAKRIAKRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNZ7</accession>
    <name>M7NNZ7_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874632.1">
        <property type="nucleotide sequence ID" value="XM_007876441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNZ7"/>
    <dbReference type="STRING" id="1069680.M7NNZ7"/>
    <dbReference type="GeneID" id="19896305"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02614"/>
    <dbReference type="HOGENOM" id="CLU_448426_0_0_1"/>
    <dbReference type="OrthoDB" id="5245063at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="742" mass="88135" checksum="A4F0E94B104A6604" modified="2013-05-29" version="1">MDILPHNDPESSSLEDLEPSLLENLDSIELEKLENEAINICSQHYNRNLYQFYINQADIQDQIQAKYQADTLRDTYEKYPLHLYDRIHVQDNIYRENIQKDILFLDTKNTFYNSIHSDFFNIDKHDRINQWDNMYQPSNMSPRDKYEKLVSWDKQILKAEEMQVVDAKGTVLQDEITKSQSYIRSFQLERDEFKVVARSKSKELVMTQTLFDKKQQLYTSPIENLQKQYVFSSEKHIVTQKEMEDNLNQVLTENRFQKKGLQEVEELITQFEYPKKQVNCSFNMPFEFPTKKAFESEEKVIDSPVKRKRRSKKYVSLDNTVHEYEYVMGNYYLKNNENLELRVISKAIFQQINDNKKLQFIEELFDYRIDYIFKYNDSTIFDILSSYTLPGFSVSVSSIVVKFITRSLTTLNPVLVFLFYLMDYVMVIWKICLEKNYKEPIRYMVSFVHFMFVFQLHIFNELVNVDKIEFLLMLLQNTIMEYMAVTKEIKVFGYIDEFVIQKCLEILNIIVSLSQENTQIVYKISLFLEFNQILILLNPLHNLLFIKKTLKFLNKCILLNCIQYTVKKDDLICFSDYFSKILDIVSRYLTEKYENYDIFERMDLKLETVMFLNTIISASVNGKDLLSLNVVVVSQLCRCLAELISLHDTSEISRQRINLIQSIVFILHEIISPINISLHFAQPWTRYAYIVSMTRLSFAEDEDDHGKDIFNDRTIEFARDLLEIVVDSEEGNELYGLFNISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPS3</accession>
    <name>M7NPS3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear condensin complex subunit 3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02450</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CND3 (condensin subunit 3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874458.1">
        <property type="nucleotide sequence ID" value="XM_007876267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPS3"/>
    <dbReference type="STRING" id="1069680.M7NPS3"/>
    <dbReference type="GeneID" id="19896143"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02450"/>
    <dbReference type="eggNOG" id="KOG2025">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004446_1_0_1"/>
    <dbReference type="OMA" id="NHQKNFV"/>
    <dbReference type="OrthoDB" id="27187at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990814">
        <property type="term" value="F:DNA/DNA annealing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027165">
        <property type="entry name" value="CND3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025977">
        <property type="entry name" value="Cnd3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418:SF5">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12719">
        <property type="entry name" value="Cnd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear condensin complex subunit 3 C-terminal" evidence="8">
        <location>
            <begin position="529"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="859" mass="100189" checksum="B863AE3063C54FF8" modified="2013-05-29" version="1">MSLTKGSIEQNIRQHFNDAQASTATHRKLVNSLLHIHEGQAKKGLEEEIEFTKEFLRNIFRILPLKKKELTADRIIKFCAHYIQHIQDKMKKSETCKQNEDESEETIASRLVRSLFDHLLPGLESKDKYVRLRICQIITLVINCMEEIDDDLFQLLKKALEKRLRDKEPSIRVQAVIAASRFQNSEEDVNSDSIKKIFLHLIQHDSNAEVRRSVILNLEKSVETLPFIIERARDTDSINRRTIFSRTLPEMGDFRQLSIGKREKILRWGIKDRNDQVKKAAVKMFSTIWIEHVNNNLLELLERLDVINSKIAEDAMNSFFSMRIDVVKTITFDSDFWENITPESAFLVRCWNDFCIKEGYTHLLEEKIPEISQQALYIEKILENFENSTDENKQELEFILEQILLIIKTTDFSDEMGRKNIFNILQNNIPNFIFSENLITHMVEVFQKIVSDERTYVKLLMEIILDLYDSLDIRTNKNKDNKEDTRSEDSFVSAVSNQDNAVSYISIDSIIKRETEESSESHKTLIIFRCLHLTQVMLENIEKNLQNNFEFIEILHNLIIPSVRSHNAPIREKSLRCLGLCCLLDKKLAKENLVLFCHCLVKGHDSLQIEAIKIMTDIFMSYKYDIFDDSSTDLHSIQLLYEQVLQNTSNLDIMATAVEAVAKLMLTSFFDDPKLLKTLIILYFHPGTASNLHLRQILAYFIPAYCYSLPKNQFCLQKIFVSTLHKLSQIFDNLEDVEYISFSQIALQMMDWIDPKKLINSDTFKNQSQYTKTNENIYLYLAKDICTQIAESYNKEKRTLCSLLNKLHITYVSDQQLAHSIQTIINTLLQENTLDSFTKNSLNKFSNALYKFTQSNQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPY5</accession>
    <name>M7NPY5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874267.1">
        <property type="nucleotide sequence ID" value="XM_007876076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPY5"/>
    <dbReference type="STRING" id="1069680.M7NPY5"/>
    <dbReference type="GeneID" id="19895968"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02275"/>
    <dbReference type="eggNOG" id="KOG0527">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1210263_0_0_1"/>
    <dbReference type="OMA" id="SETNPGM"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000041">
        <property type="entry name" value="HMG box family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="108"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="108"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="229" mass="26469" checksum="2E4F7E39A858F6A4" modified="2013-05-29" version="1">MVNMPYAHLEFVLPNETVARKQVLYPYSMKEASQYLDENKGTAYFVPHGFQPILVPQNEEDVTIQTLLDLSAPAIQVPVPLKQTLLPHYIIRPSKKQKPAKQASNKNPPRPPNAFILYRKNHQAHILRQNANLCNNDVSRIIGSMWNGESPAVKQRFHLLAQEMKEKHRAMYPMYRYCPRKSPRKRRNTKSQEQIGTEETWLSEHNAMDMQDMTITSTLQEFGATGLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ07</accession>
    <name>M7NQ07_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">mRNA export factor MEX67</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_00921</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the export of mRNA from the nucleus to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NXF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872833.1">
        <property type="nucleotide sequence ID" value="XM_007874642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ07"/>
    <dbReference type="STRING" id="1069680.M7NQ07"/>
    <dbReference type="GeneID" id="19894619"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00921"/>
    <dbReference type="eggNOG" id="KOG3763">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024991_1_1_1"/>
    <dbReference type="OMA" id="YGGHEAW"/>
    <dbReference type="OrthoDB" id="25872at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042272">
        <property type="term" value="C:nuclear RNA export factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140602">
        <property type="term" value="C:nucleolar peripheral inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14342">
        <property type="entry name" value="UBA_TAP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000018">
        <property type="entry name" value="Nuclear RNA export factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040736">
        <property type="entry name" value="Mex67_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057125">
        <property type="entry name" value="NXF1/2/3/5-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030217">
        <property type="entry name" value="NXF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005637">
        <property type="entry name" value="TAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662:SF22">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24048">
        <property type="entry name" value="LRR_NXF1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22602">
        <property type="entry name" value="NXF_NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18444">
        <property type="entry name" value="RRM_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03943">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00804">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51281">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="10">
        <location>
            <begin position="357"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="TAP-C" evidence="11">
        <location>
            <begin position="552"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR10773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="605" mass="68380" checksum="4AE9E0C478EC848E" modified="2013-05-29" version="1">MSERRKRGGRMSWRGQGRLTGKNVVDPVERDGDVVMTDDTSNLKERFNPYKASGRTKKAFKGHFYDTPTEIMITGYDGGTEDDLIGFIFRKSHVLITNLHYDGSILYASVSSCANARALLKLSGSRFAGKNLFISIPDTQKDQVMSMASSTSSTSIPITKQSTINILLEFLSSKYIHETKTLDLSSMHSNPILVNAGMFSSVLASIKTFPALMKIAKREFPNVITVNLSSNKITSLINVSSLAQTYPNLKNLNLANNLLKYYKDFDIWSHKDKLPNLQELILIGNEIRENEIKKGNEIIYRSEIIKRFPNLKLLDMVPVAQTIQFDIKDSSINNFGKTILPKKICGSFFESDLTKNTVMAFLEKYFSLYDNDRLNTVSLYNQNALFSISVNTVAPRKREPGVFSYSSSQFSEYISMSRNLMRLSSLDARVAKLNIGHADISRAFSALPKTRHNFSDSNLYCVDAWPLKGVLSTDLDPNGLVGIQIILHGIFFELKGKRETKKSYDRTFIIGPDNGNITIRSDMLIIRPYGGNNSFCINKQDETLSSNNTYEEQKQFMLNEISKKTGLNQKFSLMCLEQNQWNMEQAMNNFNILKEKGVIPLEAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQI0</accession>
    <name>M7NQI0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II transcription factor B subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">RNA polymerase II transcription factor B 38 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">RNA polymerase II transcription factor B p38 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_02304</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874300.1">
        <property type="nucleotide sequence ID" value="XM_007876109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQI0"/>
    <dbReference type="STRING" id="1069680.M7NQI0"/>
    <dbReference type="GeneID" id="19895997"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02304"/>
    <dbReference type="eggNOG" id="KOG3800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048466_1_0_1"/>
    <dbReference type="OMA" id="YMKDSVI"/>
    <dbReference type="OrthoDB" id="5963at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061575">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001174">
        <property type="term" value="P:transcriptional start site selection at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16573">
        <property type="entry name" value="RING-HC_TFB3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000037">
        <property type="entry name" value="Cdk-activating kinase assembly factor MAT1, centre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004575">
        <property type="entry name" value="MAT1/Tfb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015877">
        <property type="entry name" value="MAT1_centre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00570">
        <property type="entry name" value="cdk7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683:SF13">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06391">
        <property type="entry name" value="MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17121">
        <property type="entry name" value="zf-C3HC4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="17"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="149"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR09351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="326" mass="37862" checksum="C154AA77EF831CDE" modified="2013-05-29" version="1">MKTDLEEKKTLKKDEKCPICRNDPYLNPNMRFLINPECYHKMCESCVARIFTLGPSPCPKCGKILRKGRFREQTFEDMTVEREIDIRKRISKICNKRPEDFETLTQYNDYLEEVENITFNLVNNIDVEETETKLIAYEAINKKSIMVNAQKAELEAQIIAQNEDRLKKEKKISQKMIIKEKEAEHIEKEEYKQELIRELASSDKQASKIVEHSNALSLKRSTIRKQRAAYEAKIAIAALSTFQNSCLNKGEQKLDVFSPMAGQNKENTLYVVKETYNDSFLKPLLENKTIRGGGFNINDVYKRVLFEAFASLYFENSNNKPQTNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQS6</accession>
    <name>M7NQS6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidate cytidylyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872575.1">
        <property type="nucleotide sequence ID" value="XM_007874384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQS6"/>
    <dbReference type="STRING" id="1069680.M7NQS6"/>
    <dbReference type="GeneID" id="19894375"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00677"/>
    <dbReference type="eggNOG" id="KOG4453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031477_0_1_1"/>
    <dbReference type="OMA" id="IIYLSWT"/>
    <dbReference type="OrthoDB" id="5673at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141035">
        <property type="term" value="F:CTP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101026">
        <property type="term" value="P:mitotic nuclear membrane biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001210">
        <property type="term" value="P:regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037997">
        <property type="entry name" value="Dgk1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303:SF1">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="27763" checksum="BD088B839486CA0C" modified="2013-05-29" version="1">MVHSKKKVWKLNSKNVQSQWYRKWIIEWEVPRKCVHSSIGVITLEFYRQRFEATMITPYLVMLFIPAFGCDLIRFSVPKFNHMYIAILGPLMRQNEINTWNGVIFYLIGTWTVLIIFPKDIAVISILLLAWCDTAASTMGRMYGHYGPLIRPGKSLIGTIAACIVGMLSVYLFWGWIARFDEPNLSWHPSSRLNIHGLALLTGLIGGFTEQLDLWKLNDNCVIPVMSGSLLYIILKSISIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NR55</accession>
    <name>M7NR55_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein transport protein GOT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02180</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GOT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874163.1">
        <property type="nucleotide sequence ID" value="XM_007875972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NR55"/>
    <dbReference type="STRING" id="1069680.M7NR55"/>
    <dbReference type="GeneID" id="19895873"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02180"/>
    <dbReference type="eggNOG" id="KOG1743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124519_1_0_1"/>
    <dbReference type="OMA" id="MWLTDAQ"/>
    <dbReference type="OrthoDB" id="204784at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000137">
        <property type="term" value="C:Golgi cis cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045176">
        <property type="entry name" value="Got1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493">
        <property type="entry name" value="CGI-141-RELATED/LIPASE CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493:SF9">
        <property type="entry name" value="GOLGI TRANSPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="15728" checksum="B41A47A68E206476" modified="2013-05-29" version="1">MWLTDNQKIGVTLTALGIGFIILGIVTLFDASLLIIGNLLFISGLILIIGFIKTLVFFSRRQKLWGSVFFFLGMLLVFFKKPFFGFIIETFGFINLFGNFFPIIISFLTQFPIIGHILRISFIKKILDRVIGIYQIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRC4</accession>
    <name>M7NRC4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">V-type proton ATPase subunit F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_01983</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Vacuole membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873963.1">
        <property type="nucleotide sequence ID" value="XM_007875772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRC4"/>
    <dbReference type="STRING" id="1069680.M7NRC4"/>
    <dbReference type="GeneID" id="19895677"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01983"/>
    <dbReference type="eggNOG" id="KOG3432">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135754_0_0_1"/>
    <dbReference type="OMA" id="IIICQHI"/>
    <dbReference type="OrthoDB" id="10261947at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10580:FF:000004">
        <property type="entry name" value="V-type proton ATPase subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="entry name" value="ATPase, V1 complex, subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005772">
        <property type="entry name" value="ATPase_V1-cplx_fsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01101">
        <property type="entry name" value="V_ATP_synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861:SF2">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015945">
        <property type="entry name" value="ATPase_V1_F_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="AtpF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR015945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR09802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="123" mass="13970" checksum="741FFD1EB14C0966" modified="2013-05-29" version="1">MSNLDTIQERSLIGIIGDEDSVTGFLLAGIGHIDNEQKKNFLVVGTETETSVIETFFEELTDLRTDIGIILINQHIADRIRPKIEAYSQVLPSLLEIPSKDHPYDLEKDFILKKVRRLMSDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRJ7</accession>
    <name>M7NRJ7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01921</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFG1/PHD1/stuA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873897.1">
        <property type="nucleotide sequence ID" value="XM_007875706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRJ7"/>
    <dbReference type="STRING" id="1069680.M7NRJ7"/>
    <dbReference type="GeneID" id="19895615"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01921"/>
    <dbReference type="eggNOG" id="ENOG502QW2C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_426482_0_0_1"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000003">
        <property type="entry name" value="Ascospore maturation 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029790">
        <property type="entry name" value="EFG1/Phd1/StuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792:SF1">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="6">
        <location>
            <begin position="85"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="642" mass="72957" checksum="41704F78D7A66889" modified="2013-05-29" version="1">MAHVSVLKIRSMQNSVPILLTQQNDPILPKRSRARPAEPMKGEQPSQNSTLAYTVSEAGRESNEQADLSEFDPTGQTCPPGGKPRVTTTFWEDEGTLCFQVEAKSVCVARREDNDMINGTKLLNVAGMSRGKRDGILKGEKVRSVVKVGAMHLKGVWIPFERALEFANKEHITDLLYPLFVTNIKAFLYHPTNYVRTTAVMAAAQHFQMLRLSRNRNQSVTRRLKERQMTPPHTAPILVNRRWSQEGTMPTNTSTYMNASTVTQSLPVTPVTTPPGYFLRSAVHSSQETSQNYVFSYSEPRSKICHGKRFQQTYETPILRSLWEISRERRASASSVSLDQEELKQASEEDYIKHQPLYREMLSQQNQPLHEIMVQNPSLLSPVSHEYIQKEGIHANSGVSMTIPGLVYQASDDASTINSQSSYSYQSVDDTYLYLPNTTNMPSTLNDIDPGQTSAHFPITTGINQWRQQDVLNSRHYSIDHNKEPSMFMKTWSPQTWKEASRCKGFYHQMVDASLDNQLSRSASIDQAYLSLRNISDNHQNNHSDIHLNMERIANEDETDEFSNGKYIEQDMSTSSSFNSVLLSDVSDIKANMFSNVIKPHKRRKTIHEYMPVLIQKNKTNADLNQNVYNMETHGCHLVLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRP0</accession>
    <name>M7NRP0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lysosomal cobalamin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872314.1">
        <property type="nucleotide sequence ID" value="XM_007874123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRP0"/>
    <dbReference type="GeneID" id="19894134"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00436"/>
    <dbReference type="eggNOG" id="ENOG502QQ2T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028341_1_0_1"/>
    <dbReference type="OMA" id="FWAQFVF"/>
    <dbReference type="OrthoDB" id="73273at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072665">
        <property type="term" value="P:protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050854">
        <property type="entry name" value="LMBD1_LysCbl_Transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16130:SF2">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORT ESCORT PROTEIN LMBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16130">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="64866" checksum="13AB33DB1E60B26A" modified="2013-05-29" version="1">MEGKDQSVIWAIYISIILVFFFGLFRWIYQRQNKDKKSMIMIGIIVIIMVHMIGTLSLYPIDIGIVWLKEKNIEKDYLKKIVFLERKRFKLCYYIFYGLHIIELFIILPFVYYFYEEWNEESTIKTRIFGALRRSLFFLLLFIALFFSGTFMSITEKKNSKLYLKHFQQTFKPEYIKMSTFFIVDVVLLFGIILFCIYTAFGFSLFPLQIIKTNSINVPASVTDIKHALILNREKQRAIEVRYTGFYTQMNLKDRRALESLQREERTLVRCIRLAEEGKRKWEQPISTILHLLQLLLGFFFLVISIGITLLMSMTIISKLENTYFKILYNYISKKWPFYCMSTLSQYLFKTFPINLIMITLFILYFYVTTIVAIFNTKMTKKFTFFKYNIHKKIKNNTLHHDFLISLAILMLMVFSFNYTLSEIIIPKYYTHQNNQSHYNYAIFNSQKIYNYRNLLKSIFLSFKAQDHPSDRLYTLTVLNTIINDITSNYEFFKTWYSYSYLLFLAVFLLSFIILSFCSRTENIQNNTEIEPEREVFFLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRX8</accession>
    <name>M7NRX8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 3 subunit B</fullName>
            <shortName evidence="8">eIF3b</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Eukaryotic translation initiation factor 3 90 kDa subunit homolog</fullName>
            <shortName evidence="8">eIF3 p90</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Translation initiation factor eIF3, p90 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PRT1</name>
        <name evidence="13" type="ORF">PNEG_00521</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="8">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 9">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the eIF-3 subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872409.1">
        <property type="nucleotide sequence ID" value="XM_007874218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRX8"/>
    <dbReference type="STRING" id="1069680.M7NRX8"/>
    <dbReference type="GeneID" id="19894219"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00521"/>
    <dbReference type="eggNOG" id="KOG2314">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011152_4_0_1"/>
    <dbReference type="OMA" id="LWGGPQF"/>
    <dbReference type="OrthoDB" id="10250414at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12278">
        <property type="entry name" value="RRM_eIF3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000419">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000235">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03001">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011400">
        <property type="entry name" value="EIF3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034363">
        <property type="entry name" value="eIF3B_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EIF3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036424">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 8 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="82"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="702"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR11508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="773" mass="90059" checksum="36BD12877C089A53" modified="2013-05-29" version="1">MEEKVEVFQSDLKKKRDNLEQISPNCDITIRDEMNLNNNEKKEDLEDQEESKDYLESSIDDEIDFSDLEAKYHIPFKQDFGPLIIVDGIPQVPEEKREALLKILKKQFSTVGKINEERIFMPMEERNGVLFSKGYLFMSYQTQKEAEAAIKAFNGKKLDKAHTFLINKFTDVETALAFDEEYKETLEEKAYENKNLYSWLIDPKARDQWVMYKGDDVGIYWNQKSEAPESIIHRINWTETYIHWSPLGTYLASFHRPGIQLWGGESWGKIARFPHPSVKLIDFSPCERYLVTWSNEPIPCYPEDHPGRLTFGSEDEGKSIIIWDIKTGVLLKSFNTSISSGTDTDEVPRKITWPMYKWSSDGSYFAKVTPGQHISVYETPSMTLVGKKHIKIDGVVDFEWSPSKLEDKKGNKEYLLCYWTPEINNQPARTGLLSIPSKETIRTKNLFNVSDCKLHWQSQGNLLCVKVDRHTKTKKSTFTNLEIFRIHEKNIPVEVIEIKDVVINFAWEPNGDRFALITTSDSNFCQGPLINVKNSLSFYCTEKSKGSNGNFKLIRTFTKKTCNSLYWAPNGRFIVAATLGNATNFDIEFWDLDFEGEKKDTDKDLNANLQLMGTAEHYGVTDIEWDPSGRYLTSSVSIWRHRMENGYRLWDFKGSLLREEHNEGFKQLLWRPRPPSLLSKEQQKKIRKNLKEYSRAFEKEDVQEQNTANKELIAHRRRLLEEWNAWRSKVISNLEKEKKELGIVTDTKEEKKEKYIKKIIEVVISEEIEEVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NS25</accession>
    <name>M7NS25_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00003</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ERGIC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871853.1">
        <property type="nucleotide sequence ID" value="XM_007873662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NS25"/>
    <dbReference type="STRING" id="1069680.M7NS25"/>
    <dbReference type="GeneID" id="19893701"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00003"/>
    <dbReference type="eggNOG" id="KOG2667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034705_1_0_1"/>
    <dbReference type="OMA" id="QRHEGCR"/>
    <dbReference type="OrthoDB" id="270930at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061852">
        <property type="term" value="C:retrograde transporter complex, Golgi to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF25">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="8">
        <location>
            <begin position="7"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="7">
        <location>
            <begin position="140"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR11558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="385" mass="43718" checksum="BD507C2011419687" modified="2013-05-29" version="1">MSQRTGFRRFDAFSKTIEDAQIKTINGGFITILSIIVIFVLISFEWHDYRQIVILPELTIDRSRGEKLQINLNLTFPKIPCSILSLDVMDVSGELQTDVSHNVVKNRLDSNGVFINSTSLNTLNFQQPTKIYPPDYCGSCYGAKEGCCNTCQDVIDAYTSNDWPIPDTKAFEQCKENYNNLNDSDEGCNFVGRIEVNKVIGNFHFAPGHSSQIMRNHIHDIYDYMTDSLPHDFSHTINKLSFGPEIEGRSLQNPLDNVKKETNNPTLKYSYFIKCVAYRFEYLSKPSLDTNKYSVTVHERSVSGDSDPNHPTHVSPKDGIPGVFFSYDISPIKIIEKETRGNFSTFLTSTVIIISGVLTIAGIVDRILYETERQMEKKLREGKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSP0</accession>
    <name>M7NSP0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein phosphatase inhibitor 2 (IPP-2)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873477.1">
        <property type="nucleotide sequence ID" value="XM_007875286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSP0"/>
    <dbReference type="STRING" id="1069680.M7NSP0"/>
    <dbReference type="GeneID" id="19895227"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01532"/>
    <dbReference type="eggNOG" id="ENOG502S2VH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070379_1_0_1"/>
    <dbReference type="OrthoDB" id="551302at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007062">
        <property type="entry name" value="PPI-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398:SF20">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY INHIBITOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398">
        <property type="entry name" value="PROTEIN PHOSPHATASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04979">
        <property type="entry name" value="IPP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="23764" checksum="B5EF2F0B3DC1DADD" modified="2013-05-29" version="1">MISKGLSELPKPHKGILKNKNEVIRSFNASSKDIYGDSVENSFSQSQLAPLNIESSETSSPRLKWDEANLYLTEQEKTSTMKITEPKTPYTRQYDSSVSFDEEIMDSDQELINKQNNSDIPVFDLGEPQEKMPVLLKHVIVKDAGIEKDKEDMQTPEDEQHRRHFELMRKKHYEKMGTTAFSHEIDPDDESDSESDISLQTNGKAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTH7</accession>
    <name>M7NTH7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873026.1">
        <property type="nucleotide sequence ID" value="XM_007874835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTH7"/>
    <dbReference type="STRING" id="1069680.M7NTH7"/>
    <dbReference type="GeneID" id="19894808"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01111"/>
    <dbReference type="eggNOG" id="KOG2319">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007625_3_3_1"/>
    <dbReference type="OrthoDB" id="300289at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041545">
        <property type="entry name" value="DUF5601"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18151">
        <property type="entry name" value="DUF5601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="261"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="1">
        <location>
            <begin position="526"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="571" mass="67030" checksum="70F0BAA3005F3B83" modified="2013-05-29" version="1">MKDSERTLNDEKRNNELIVKEKEHCEEYFDEFNLSKYQRCLERKPSIQTEKTHILGTFSSLMDEKCMEVTYSDFLDKKSIDMSIISETNLFQRITLDYPKSTSEDSEKEKNMDSVFSNNRRNNMFYKKDLEKDIKENHFENVLTFKLESKLLRNLDFRKFVNQLRCKSAISIAKYMKSFIYEFLQKPWTIKEKVKIIHDFLRFIYLKMQLVEPWINTSEIEFDNAKEGMEKLITIRLYEQIFSPAISYLLDDDISGHSDDLERDRIIQEKISMFNWIREEHIEIPYTNLNKKFLELAGQELLKINAYRSPRDKIFCILNCSKVIFGLLRYAKIEESADKFIPTLILIILKTNPEHLISNIQYISRFRNPDKLSGESEYYFSSLIAAVAFIENLNKSSLTISNEEFEKNLEHSIIRISQQKNKDDRIKNAQSMTFALLEPAKEYIASKSSDVFRNIQKPLLSLGKIFMDQNTEKSYQPIIKQLSSNQIPQNIISTTNLDEKRLMLSKINTQFPMSEIATVQETQVEIESEMLNFLSQMFPSVDLDVIGIIIDSENGKINPTIDVLLTISSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTW7</accession>
    <name>M7NTW7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit SPC19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Outer kinetochore protein SPC19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_00862</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex SPC19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872772.1">
        <property type="nucleotide sequence ID" value="XM_007874581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTW7"/>
    <dbReference type="STRING" id="1069680.M7NTW7"/>
    <dbReference type="GeneID" id="19894560"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00862"/>
    <dbReference type="eggNOG" id="ENOG502SDEQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112993_0_0_1"/>
    <dbReference type="OMA" id="ANEMAPQ"/>
    <dbReference type="OrthoDB" id="3361333at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013251">
        <property type="entry name" value="DASH_Spc19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08287">
        <property type="entry name" value="DASH_Spc19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR10712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="171" mass="19360" checksum="6B003364A4A7DD47" modified="2013-05-29" version="1">MISPRVQSRQRTTSSITPISDYLNSLEGCVSSLNACNYRMDLLLATLNTGINDFPRIQSVLANRRHFEVVSETDIQEAQQSLEHEVYPQILELLQRAEAGITKLERREKTLQGKSELQEVRLQQKPSKPRNALNSASEQLSKANELHALQVKKERLLYSLSRLSLVSGNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7NU07</accession>
    <name>M7NU07_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_01305</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873230.1">
        <property type="nucleotide sequence ID" value="XM_007875039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NU07"/>
    <dbReference type="STRING" id="1069680.M7NU07"/>
    <dbReference type="GeneID" id="19895002"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01305"/>
    <dbReference type="eggNOG" id="KOG4112">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134505_2_0_1"/>
    <dbReference type="OMA" id="IHLTLWT"/>
    <dbReference type="OrthoDB" id="263893at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009542">
        <property type="entry name" value="Spc1/SPCS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 12 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06645">
        <property type="entry name" value="SPC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR10601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="94" mass="10825" checksum="8C94F603F001D78F" modified="2013-05-29" version="1">MIFSTINIKKIEKLIYGYIDYEGQTISEILANVIVIFFSIAAYVTGFLRQNLIITLFIFIVGIITSILVIVPPWPIYNTHPIKWVKAYKSQKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NU14</accession>
    <name>M7NU14_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01314</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873240.1">
        <property type="nucleotide sequence ID" value="XM_007875049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NU14"/>
    <dbReference type="STRING" id="1069680.M7NU14"/>
    <dbReference type="GeneID" id="19895011"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01314"/>
    <dbReference type="eggNOG" id="KOG3434">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105624_0_0_1"/>
    <dbReference type="OMA" id="IMEIGSF"/>
    <dbReference type="OrthoDB" id="10259820at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.210:FF:000001">
        <property type="entry name" value="60S ribosomal protein L22 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF31">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL22A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="14026" checksum="EF88243A6CDA2C7B" modified="2013-05-29" version="1">MINKAPKKAQKQTIKKFTLDASGPVDDRIFDISAFETFLHERIKVEGRTGQLSDSVLISREGEGKITIVTHVSFSGRYLKYLTKKFLKKHQLRDWLRVVSTMKGTYELRFYNVVVDSGNEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NU87</accession>
    <name>M7NU87_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01374</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873305.1">
        <property type="nucleotide sequence ID" value="XM_007875114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NU87"/>
    <dbReference type="STRING" id="1069680.M7NU87"/>
    <dbReference type="GeneID" id="19895071"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01374"/>
    <dbReference type="eggNOG" id="KOG2957">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051277_0_0_1"/>
    <dbReference type="OMA" id="MTYGYMI"/>
    <dbReference type="OrthoDB" id="10250083at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018497">
        <property type="entry name" value="V-ATP_synth_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="2 3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR018497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="349" mass="40371" checksum="A07178CBBE1D9FE4" modified="2013-05-29" version="1">MGILKDCLFCQDINYIDGLIRGYKANFLTNSTYQYLTQCESLEDFKMQLSSTAYGSFLSNVSTLTTSVIARKATEKLTSEFQYIMSQAVYPLSKFMEYITYSYMIDNVILLITGTLHERDTHELLEKCHPLGCFETMPTLCVSKDIEEFYNNVIIDTPLALYFKDCLSAVDLNELNIEIIRNTLYKAYLEDFYAFCRTLGGTTFELMSNILKFEADRRAINITLNSFSTILTKETRRKLYPTIGNLYPEGTYLLSSAESIEEVKLAIKGVPEYYSFFKEDASHENKKSLEDIFSEKEAELNKQTFVQQFHFATVYAWVKLFEQEIRNIAFLSECITQNQQNYATFVSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUD4</accession>
    <name>M7NUD4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872966.1">
        <property type="nucleotide sequence ID" value="XM_007874775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUD4"/>
    <dbReference type="GeneID" id="19894751"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01053"/>
    <dbReference type="HOGENOM" id="CLU_1579196_0_0_1"/>
    <dbReference type="OrthoDB" id="539158at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="19985" checksum="344ACC4B6A1420EE" modified="2013-05-29" version="1">MERILLKELPEDLPFYPGQIICTGEFSVTRLSVDLKITHYFSTQLISSDICTQKVFPIEAYILFLIKITYLQNIKPKNILHHGNEILKYRISVLYHYSDIVIKQESYLRSIEFHPNMTEKQKILGLSELFYIHYFLEILYGLLTINPSERMTLQKASDHPRVNRKNCFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUL7</accession>
    <name>M7NUL7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 1, mitochondrial</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSD1</name>
        <name evidence="13" type="ORF">PNEG_00603</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 alpha chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
        <text evidence="12">Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 beta chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872500.1">
        <property type="nucleotide sequence ID" value="XM_007874309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUL7"/>
    <dbReference type="STRING" id="1069680.M7NUL7"/>
    <dbReference type="GeneID" id="19894301"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00603"/>
    <dbReference type="eggNOG" id="KOG2420">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029061_1_1_1"/>
    <dbReference type="OMA" id="HSPASWV"/>
    <dbReference type="OrthoDB" id="4330at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03208">
        <property type="entry name" value="PS_decarb_PSD_B_type1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033661">
        <property type="entry name" value="PSD_type1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF6">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023297209" description="Phosphatidylserine decarboxylase 1 beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023297208" description="Phosphatidylserine decarboxylase 1 alpha chain" evidence="12">
        <location>
            <begin position="448"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="12">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="12">
        <location>
            <begin position="100"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="447"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR11002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="483" mass="55751" checksum="CF104E490E91E82A" modified="2013-05-29" version="1">MFVCQKKKSKIMGSCLANRYYKRLVTVRPIVRCWSKISSGQSRILSILYSSRRFVCSKEGSNELWASRLDEGWNYTKIQWYSIPLTVGIVYVAFAHYRNSKKKYKTEDVLENSGTRLSDDIHVCGFWQFYILKSLPLKALSRIWGKCSEITLPVWLRVPAFKLYAWVFGCNLYEMAEQDLRKVKNFSEFFYRELKPGVREIDNDALIVSPADGKVLHFGLVEGRRIEQVKGLSYSLDALIGDSSTLSNNGIVFDKNFIKASEQEMHFSETNGISHSHALYNENEKKYGFHVNIDTNKIENDIILGYDIMDRLKEGNRLYFAVIYLSPGDYHRFHSPTNWVVEKRRYFSGELYSVSPYFARRITNLFILNERVVLLGQYRYGFMSMIPVGATNVGSIRIDFDKDFRTNVVEKSTPKGTYTEATYFAFSDFLKGYPLRIGQQMGGFNFGSTIILIFEAPQDFEFLVSEGSRILMGQCLGRVNSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUN3</accession>
    <name>M7NUN3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00944</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872857.1">
        <property type="nucleotide sequence ID" value="XM_007874666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUN3"/>
    <dbReference type="STRING" id="1069680.M7NUN3"/>
    <dbReference type="GeneID" id="19894642"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00944"/>
    <dbReference type="eggNOG" id="KOG3497">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143122_1_1_1"/>
    <dbReference type="OMA" id="YCCRRMF"/>
    <dbReference type="OrthoDB" id="10258858at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00250">
        <property type="entry name" value="RNApol_arch_Rpo10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020789">
        <property type="entry name" value="RNA_pol_suN_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003089">
        <property type="entry name" value="PRK04016.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431:SF3">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005653">
        <property type="entry name" value="RNA_pol_N/8_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01112">
        <property type="entry name" value="RNA_POL_N_8KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="66" mass="7895" checksum="19019B62CA3DEF10" modified="2013-05-29" version="1">MIIPVRCFSCGKVIGDKWDMYLIYLQEDISEGEALDKLGLKRYCCRRMILTHVDLIEKLLHYNRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NV69</accession>
    <name>M7NV69_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription initiation factor TFIID subunit 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872683.1">
        <property type="nucleotide sequence ID" value="XM_007874492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NV69"/>
    <dbReference type="STRING" id="1069680.M7NV69"/>
    <dbReference type="GeneID" id="19894478"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00780"/>
    <dbReference type="eggNOG" id="KOG3334">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068315_3_1_1"/>
    <dbReference type="OMA" id="PHDAQVM"/>
    <dbReference type="OrthoDB" id="341924at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07979">
        <property type="entry name" value="HFD_TAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR11187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="16310" checksum="5C2ED69EFAE2002D" modified="2013-05-29" version="1">MSEETSREQKRIPRDARIVHLILASLGVEAYQQNVPLQLLTFAHRYTHQVLQDALVYSDYARPDGVTGLTVEDIRLAIASQVNNSFRGPPPKEFLLELASERNRKPLPPIYPTYNLRLPPKKYLLTAPNWDFDIPKSKKDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NV79</accession>
    <name>M7NV79_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 28</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ESCRT-I complex subunit VPS28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00789</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the VPS28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872693.1">
        <property type="nucleotide sequence ID" value="XM_007874502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NV79"/>
    <dbReference type="STRING" id="1069680.M7NV79"/>
    <dbReference type="GeneID" id="19894487"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00789"/>
    <dbReference type="eggNOG" id="KOG3284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076417_1_0_1"/>
    <dbReference type="OMA" id="CDEFPTV"/>
    <dbReference type="OrthoDB" id="2671at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904669">
        <property type="term" value="P:ATP export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1130:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007143">
        <property type="entry name" value="Vps28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017899">
        <property type="entry name" value="VPS28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037206">
        <property type="entry name" value="VPS28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017898">
        <property type="entry name" value="VPS28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038358">
        <property type="entry name" value="VPS28_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03997">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017535">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140427">
        <property type="entry name" value="VPS28 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51310">
        <property type="entry name" value="VPS28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51313">
        <property type="entry name" value="VPS28_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0967">Endosome</keyword>
    <keyword evidence="4 5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5 6" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082697" description="Vacuolar protein sorting-associated protein 28" evidence="7">
        <location>
            <begin position="20"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="VPS28 N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="VPS28 C-terminal" evidence="8">
        <location>
            <begin position="130"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="225" mass="25727" checksum="BEE198DF1E3AA2CE" modified="2013-05-29" version="1">MRLVCVIYALCIFTMNTLEKVCLYETSAERNVWESLSDIYSIIRTLEFLEKAYLRDIISSDEYTPTCLRLLAQYKTILKSPSVANAFESLETFCAVYEISCFHAIYRLNVGVPVTIEHVTKTSSLPESGVSAKQVAEAVQNFITFMDALRLKYTAKDQLHPLLSELMVSLNAVTHETFEGRGIILHWLILLNNMSASEEITEKQSRQMLFDIEGVYNEFYKSLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVD2</accession>
    <name>M7NVD2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">REM-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00695</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RICTOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872593.1">
        <property type="nucleotide sequence ID" value="XM_007874402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVD2"/>
    <dbReference type="STRING" id="1069680.M7NVD2"/>
    <dbReference type="GeneID" id="19894393"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00695"/>
    <dbReference type="eggNOG" id="KOG3694">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001013_1_1_1"/>
    <dbReference type="OMA" id="EIRIHAT"/>
    <dbReference type="OrthoDB" id="271111at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028268">
        <property type="entry name" value="Pianissimo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028267">
        <property type="entry name" value="Pianissimo_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029453">
        <property type="entry name" value="Rictor_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029451">
        <property type="entry name" value="RICTOR_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029452">
        <property type="entry name" value="RICTOR_V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298">
        <property type="entry name" value="CYTOSOLIC REGULATOR PIANISSIMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298:SF11">
        <property type="entry name" value="RAPAMYCIN-INSENSITIVE COMPANION OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14663">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14666">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14664">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14668">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01303">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01307">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01308">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01310">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR N-terminal" evidence="4">
        <location>
            <begin position="149"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR middle" evidence="3">
        <location>
            <begin position="591"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR" evidence="5">
        <location>
            <begin position="985"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR11096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1188" mass="136863" checksum="6DDC66DC5FCDE372" modified="2013-05-29" version="1">MKNINELDELMNQLDIENKIKEGAENLLQVFDQRTEDKEDENHITLRKKIELELDAANSKIAKLKAKVNIIKSKTQIDSIKSNTKTINTFYEQDTKSSALPYSISSKSVHSSISIGEKDEQIETIDPIQSLQIAFKNLYESIHDSGQYLKHANHLVSLFKSHPTLKYDLNWEALGHHLQIMFSSSDTNKISSGYRIARYMIYDLTSISFVKKFHVEHAIIRSFVKDNSTSKEREQALKLIRTFYGIKDGISEISKSVVSAIVSLAEYTKDKMSLISIETLAEMLILDPALIVSAGGNKVLLQTLSDGPFEIANEVAKLFIYLLDTPATRKFIRPKSDLQLILSNVTNFRPIMEEYRLKYCGDGIVSIMKSWSGLIYMSMYDMQAIRSLIDVLRISSSRSQDIILDILYNLFGIKSSSITSTFLAGRRLTTWGRPSPSQQEPHNEGMFANTFTEFGRNDLSQQFLALIIMIFMDIGILDTLMAVAEDSKDKMIFRKTTLLIVELLHLSNRILPLQYGVKLQSLPKLFMSALEFSSEEHFIATSAILQIESLNRIKMKTNFVQQKERSTSSENPLKRGQRQLEQVKIKLGLQIDDIRFRTLLLDTQVLNTKNYKKWRWDIVIELLHGPLLNPKRLEESIRSTKFIKRLLSFYLPFNYKFSNIKQTKPNQRYIKIGRMIFTTLLANPEGIRYLSDSKLLRQISECLAQLDPLSGVSCPSPLFSKQRLEETLSSGYFVFLGTLSENKDGIAMMEKWKIFNMFYHLTELRSRDDLILNFIINMNYIFYGHPRIILSKALTTGLKDVRLFVTKHLGTLLSSNKKFTKNTKSIEWAISLLVTQLYDPCIEVCQMAVEVLEKACYDFENLQYTVKLRPALEHLGSIGAPLRLRFLASSTGFNYLKEFDYIEKEMDNWFHEQNEIYVNYIENYLSLAFSFTKKNEFDGLIPPHFYGEIIKTSEGCQLLKNKGHFEYFVSNIFKHKDEYEDKNIILHLKSSLWAVGNIGSHNNGFPFLENSGVISEIIHIAEKSQVISLRGTAFFVLGLISITMSVSQILKQHGWISVFTSFGIPIGICVPKDIKKILFLEPWNYYSCLSDLEENIKLVSKNIIQDEILKIITDLSSNIFVTKALKSLSRIKSKYPEEFKSLDLYKSVLKILTSYRYQQPIRKFILEMFPSDIFYQNSELFDYNKSVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVH5</accession>
    <name>M7NVH5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ubiquitin-activating enzyme E1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PNEG_00306</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">B123</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 12">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872179.1">
        <property type="nucleotide sequence ID" value="XM_007873988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVH5"/>
    <dbReference type="STRING" id="1069680.M7NVH5"/>
    <dbReference type="GeneID" id="19894004"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00306"/>
    <dbReference type="eggNOG" id="KOG2013">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_7_3_1"/>
    <dbReference type="OMA" id="TPSEHIH"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000618">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000002">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028077">
        <property type="entry name" value="UAE_UbL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030661">
        <property type="entry name" value="Uba2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF5">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14732">
        <property type="entry name" value="UAE_UbL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039133">
        <property type="entry name" value="SUMO_E1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 12 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="17">
        <location>
            <begin position="8"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin/SUMO-activating enzyme ubiquitin-like" evidence="18">
        <location>
            <begin position="435"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="13 16">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="26"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="58"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="119"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR039133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF14732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMR11277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="598" mass="68831" checksum="E67300AC85FAFB4B" modified="2013-05-29" version="1">MIQQKIEKQCEDLISKTSSSKVLLVGAGGIGCELLKNLLLSGFCEIHIIDLDTIDLSNLNRQFLFEKKHIKKPKSLVAKENAQKFNPKAKLKAYHSDIKDPRFNIFWFQKFTLVFNALDNLDARRHVNKMCLIAGVPLIESGTMGFRGQVQVIIKGKTECYDCNPKETPKTYPICTIRMTPTLPIHCTVWAKSYLFSHIFDTKKTFDTEKHEKEDMHDLYITKNIFKNIKDSIKDENFAEKLFKKLYFDDIIQLKSMEEISRILKTINPLSYEDLKSKSDTIDKERLKNSQLVWTIEENFYIFLLSLENLRRRFISLLDSFSDNKSAIPFDKDDEDILNFVSSSANLRSYVFGIEQKSKFEIKQMAGNIIPSIATTNSIISGICVLQAFHVLSNNFNSLRTVFYSRRPERVFNSAPASFPNPQCELCGIETSIFSVDINSATLKNLVINVLQEGLGYGEEISIISDRLLYDIEFEDNLDKLLKDIGVQNGTFLTIIDENDNEKLNRKNLILVIKEKTFKNTEKPYSMLNITIPRHSYNHEAERNDITNENNNDNDFQVLKKRKSDYLNSESNLIAKKTKMDPIVIDDDDSDVIVLDCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVI3</accession>
    <name>M7NVI3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">mRNA decay factor PAT1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00321</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PAT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872194.1">
        <property type="nucleotide sequence ID" value="XM_007874003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVI3"/>
    <dbReference type="STRING" id="1069680.M7NVI3"/>
    <dbReference type="GeneID" id="19894019"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00321"/>
    <dbReference type="eggNOG" id="KOG4592">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012622_1_0_1"/>
    <dbReference type="OMA" id="HISHEQR"/>
    <dbReference type="OrthoDB" id="74835at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039900">
        <property type="entry name" value="Pat1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019167">
        <property type="entry name" value="PAT1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551:SF0">
        <property type="entry name" value="PROTEIN ASSOCIATED WITH TOPO II RELATED-1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551">
        <property type="entry name" value="TOPOISOMERASE II-ASSOCIATED PROTEIN PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09770">
        <property type="entry name" value="PAT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="mRNA decay factor PAT1" evidence="7">
        <location>
            <begin position="25"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="mRNA decay factor PAT1" evidence="7">
        <location>
            <begin position="232"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR11292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="711" mass="82767" checksum="3B2A11A3555C7346" modified="2013-05-29" version="1">MAFFDWETYSKNTESEALSMGHINEELGESFEFENMYDGLGEILEETKDDMNEDTFGVNVEDVGRDFDFSTNTQKMADIINKEQAFYKKKDKIIEKTSDTESLPVGKENEKISDIQYVPYVSKETTHWREPYSNMRNLEYSLKLQTPSLSETSTYTNESRKKHFKGYISLEEVEAQFFEDNKRNSNESAQDNMLSKEFLNTILNTETKKNIGFLEHANSGRESSRYDFNTNSELQYSDLFKDKKYKKINETKLFHHNQDTNDMSQYDGLMNESDKNFINRIQLSQLVSDDPYSDDFYYYSYNSLKNKNNQQKLPDKPNSLYSLQDKQSLNFKNKNNENPILKIQQQIQNIVAAGKVRPKATQLSLEGALGKISFSTVRTPRQILSVKKPSDSTEKNNIKTCHINIQRNHKFYLYSIEKVYDCLLEIDEILRKQKQTKQENCRAIDDNEQNKKIMLLKEQILESLHITEPIPRNPNIVHPFISIISYNKGKKLIPRIFEYINSEQKLTILTMITIYLDHLDVVVYDLYNFSNESRPEYIKENIDTFTQVALPSLLAYVSEASLQIIIELLSIMLERMNLQMIAITKIGLSFLTMFISRAEIIKQSGQADESDLKQWRKIYDLMFSKLIGRFIYIFPPSLSFSDEIYPWQFMAACAISSTLEQQHILVTEVREKVMDNVISSKHLPPDIAAIKLGNVNLFLHALGLDIEQLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M7NW72</accession>
    <name>M7NW72_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872453.1">
        <property type="nucleotide sequence ID" value="XM_007874262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NW72"/>
    <dbReference type="GeneID" id="19894258"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00560"/>
    <dbReference type="HOGENOM" id="CLU_1390767_0_0_1"/>
    <dbReference type="OrthoDB" id="5360549at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="196" mass="22842" checksum="AECEAF598CBFB0F0" modified="2013-05-29" version="1">MKKRIQSDKRDYVKRRHIELEKYPSLLSENANSDHEETHAAFEISAQSTRKISAKIYLENFNSLQIDALKRMRCAIEEAREDRNANDHKFKTLLRDFLTLEDDSKYLCDAETLKNDISSFLFILTEYQLALENLIALRSSDIYKYRDEHNQETNLAKAAITKVVSNTFSQMNKTLLHKKVLKKLTKAINLALLSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>M7NW84</accession>
    <name>M7NW84_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_00007</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871857.1">
        <property type="nucleotide sequence ID" value="XM_007873666.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NW84"/>
    <dbReference type="GeneID" id="19893705"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00007"/>
    <dbReference type="eggNOG" id="KOG0951">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000335_1_0_1"/>
    <dbReference type="OMA" id="MNPKEFN"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000393">
        <property type="term" value="P:spliceosomal conformational changes to generate catalytic conformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18019">
        <property type="entry name" value="DEXHc_Brr2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18021">
        <property type="entry name" value="DEXHc_Brr2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000002">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000368">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000004">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000254">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000013">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041094">
        <property type="entry name" value="Brr2_helicase_PWI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048863">
        <property type="entry name" value="BRR2_plug"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21188">
        <property type="entry name" value="BRR2_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18149">
        <property type="entry name" value="Helicase_PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="504"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="723"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="1351"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="27"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="216"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR11562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="2154" mass="247696" checksum="F19CD590CC30A907" modified="2013-05-29" version="1">MPSKYHPPAQNMDQYKYSEISNKVSKADQRFVTRRDHEATGEPESLSGRISVKDMGSRVSRNTQPESTIKKETQVIDDEFDQKYKKKKTLKNKNTYSSILDTTEDLEGLVYYPKTKETRETYEALLAYVHEFVGDQSHDIIRSASDAVLEFLKDENLKDYDKKKEIDKLLGVNIPSERFSQLIAIGKKITDYSSEDSRNIVENDDHELDEQRVAVIFDDDENEDSENEIDEDDQEESNTSTDTEGVENYITIVNGKTNKHFTSKENKEKVFAHQIDTFWLQRTISAYYTDPYIIQEKTSSAISFLESDISFGQLENKLMELFDYDKFELVKILTRNRDTIVWCTRLLRTIDVEAKKEIETQMKLEGYEWILRELKEDRESLSLMYPEKHDNNMMDIDLPQDVEKHMHKDISVSQISEIIPKKVIDLNSLIFSQGAHLMSNKKCKLPEGSFKRSKKGYEEIHVPAPKKAIVKDIKSILISDMPEWIRPVFGNTEKLNPIQSKLYPMAFEKDNNLLICAPTGAGKTNVAILCILNELKKHRNESTGEINKNDFKIVYIAPLKALVQEIVGNFRSRLSQYDIQVEELTGDTQLTKAQISYTQIIVTTPEKWDIITRKATETSYTNLVRLIIIDEIHLLHDDRGPVLEAIVARTIRKMEQTFEPVRLIGLSATLPNYMDVAAFLKVDLKQGLFYFDNSYRPCPLKQEFIGITEKKAIKRLQVINDVTYEKVIEQARKFQVLIFVHSRKETAKTAKFIRDKCLEEETIGQILRFDAATKEILQSEAKEVNDSNLKDLLPYGLGIHHAGMTRADRRSAEELFAAGHIQVLVSTSTLAWGVNLPAHAVIIKGTQIYSPEKGRWVELSPQDVLQMLGRAGRPQYDSYGEGIIITSHTELQYYLSLLNQQLPIESQFISKIVDNLNAEIVLGTVRNRDEAAQWLGYTYLYVRMLRSPTIYNVGADYADDVDLEQKRIDLIHSAALLLDKHNLIKYDKKTGIFQATELGRIASHYYITYESMAIYNQYLKPTLSYIELFRIFCLSDEFKYIPVREEEKLELQKLLDRVPIPIKEGAEEPSAKINTLLQAYISKLKLEGFALISDMIYVTQSAKRILRAIFDISLKRGWSQVAKSALDMCKMVEKCMWPTMTPLRQFKICPSEVIRKVERKDLSWSRYFDLDPHELGELINVPKAGKLVHKLIQHFPKLQLQAHVQPITRSILRVSLTITPQFEWDHEIHGFTELFWIIAEDVNGEQILFHDQFILKENYAKDEHYVEFTVPISEPIPPNYFITIISDRWMHSETKLAIAFKHLILPEKFPPHTPLLDLHPLPVAVLRKQEFIKLYSSHFQNFNKIQTQVFNTLFTTDETVFIGAPTGSGKTICAEFALMRHWMQENSGKAVYIAPFQELIDERYNDWNEKFRTLENSKSIVKLTEETSENLKLLQKADLILATPVQWDVLSRRWKHRKNIQTIQLFIVDEIHAVGGHIGPVYEVIISRIRYVAAQTGNKVRIVALGVSLANARDLGEWIGANQHCIYNFSPKDRPRPLEVTMQSFTVPHFPSLMIAMTKPLYLIITTLSSDCSSLIFVPSRKQCRNISLDILTHCNANNNENRFLLSTSDDIMLYIGKIQDDVLANCLTHGIGYYHEALSKSDKDIVKSLYKSRIIQILFASRDVAYSLGVTAHMVIVMGTQYFEGREHRYIDYPISEILQMLGYAYQPDHDGISRAILMTPAVKKEYYRKFLSEALPIESHLQIFMHDAFVTEIATSTIENKQEAVDWLTWSYMYRRLVANPGFYGLQDISHESLSSYLSDLVETTLNDLMEKRIISIEDDFYVTPLNLAMIASYYNLTYITIETMALSLTSKTKMKGLLEVVTAAAEFESIPIRRHEDIILRRIYERIPVKLQNQDFDSPSFKAFILLQAHFSRFQLPIDLVADQVLVLQKIINLLSACVDVMSSEGYLNSSYPMELSQMCVQAIWDRDSPLKQIPHFTNDVIKRCNDTGLESVYDLGEFLADASKESRDKLLEMDSKKLRDVANFVNNYPSIDITFELEDTGSITVGNKASINIILTRETEEVNTLVYAPFFPISKNEHWWIVIGDGVSLLAIKKVTLQKVLSLKLDFIPPNAGKHEYILSCFSDSYVGVDQDIKVDIVVAEGRENNEADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWG5</accession>
    <name>M7NWG5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00505</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872392.1">
        <property type="nucleotide sequence ID" value="XM_007874201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWG5"/>
    <dbReference type="STRING" id="1069680.M7NWG5"/>
    <dbReference type="GeneID" id="19894203"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00505"/>
    <dbReference type="eggNOG" id="KOG1765">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RRTDNTI"/>
    <dbReference type="OrthoDB" id="28455at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="191" mass="22475" checksum="DA5D9648A56400A9" modified="2013-05-29" version="1">MHQNMEPSSTTNKKSIHLEFDLGNLSAFNINSLDTYSLKNNKEEYIMSFSRDSIQILVNRIFSLPKIITLNGSFIELPEPIISLPREKPIPKPRPETKWEKFAKAKGIKSKSKIDGKMTYDKNKKKWVPKWGYKGKNKNLKNQWLIEINNNNNNRDFDQRILTKSLRKERIKRNKNQNIINSNSKKKTNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M7NWS0</accession>
    <name>M7NWS0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871896.1">
        <property type="nucleotide sequence ID" value="XM_007873705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NWS0"/>
    <dbReference type="GeneID" id="19893741"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00043"/>
    <dbReference type="HOGENOM" id="CLU_1579194_0_0_1"/>
    <dbReference type="OrthoDB" id="5323663at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035186">
        <property type="entry name" value="DUF5308"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17233">
        <property type="entry name" value="DUF5308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="169" mass="18595" checksum="5F66668386699687" modified="2013-05-29" version="1">MSATVKEKSESSSNLLPLHVYFERIPSIINVPSTSIFHLTNYGAVPIFTTCTSSAQFKNLASLTSLFCQAYEMISRLQLGKPKRVVGSYFCLEDPYVGAELVQVSCTDDRMFEREMVNSMDGTKGPTEIAKVKLPLIASVVGIKGTMASIIDISKEIEKVAQIVIKNLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3E3</accession>
    <name>M7P3E3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase II subunit A C-terminal domain phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_03185</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This promotes the activity of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875248.1">
        <property type="nucleotide sequence ID" value="XM_007877057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P3E3"/>
    <dbReference type="STRING" id="1069680.M7P3E3"/>
    <dbReference type="GeneID" id="19896872"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03185"/>
    <dbReference type="eggNOG" id="KOG0323">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007683_0_0_1"/>
    <dbReference type="OMA" id="DQTVIHC"/>
    <dbReference type="OrthoDB" id="10249888at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17729">
        <property type="entry name" value="BRCT_CTDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011947">
        <property type="entry name" value="FCP1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02250">
        <property type="entry name" value="FCP1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="8">
        <location>
            <begin position="160"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="7">
        <location>
            <begin position="511"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="718" mass="82232" checksum="33433EC699DBAEAD" modified="2013-05-29" version="1">MNQEPTYVYLPPSLRFPVTVVSISAKVFQPVKKHDLLLSYRYQGTFTEYDEDGSERNVAREYVDVFQSPIEGIVDSWFVREGVVVKDQYIRILSIIEPCLHSVQYHGLCATCGRDVTQQDFMGFSDSTRATIQMSHDATKLTVSRQEAARLERETAERLLNETKLSLIVDLDQTILHATVDPIVGEWLSDPSSEHYAAVQDVQTFCLREGNASIGSWYYIKMRPGLEQFLENISKLYEMHIYTMGTRAYAASIAQLIDKDKKYFGDRILSRDESGNTTQKNIQRLFPVDTSMVVIIDDRADVWQWSPNLIKVTPYEFFVGIGDINGDFVANKPSLHNFSSSLMSASLSTLQTSPTDQQTVFSYSPETHFIPTHDNVYNDILTNDLNAVLQDDFRQAMFEHKINSLVSGNQNVLVVVDDQIKTNQSFNGMNHLEFFKKPTEKIFFHNNDTELLRLESSLRLVHKEFYKEYNRLLKTRKKHDLIASFSENINSQKYSDPDISKMDIKIIMPALKSNVLKGTVLLFSGVIPMGVDVLSSNIAQWAMNFGAEIAINISNDVTHLIATKIRTTKVKKALQQKNIKIVSVDWLLHSISHWKRLPESDYLLHSFSENDIFNNMQFQQDFHSLLDINTANSYEFISSDNKDTNENHDKDTHKVFESINNENKVDAIDWEDAIREVDEFLAESCDSALSSDDASKDKIVPTFEKKRKISYLFETDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3K8</accession>
    <name>M7P3K8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_03263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the Golgi-associated retrograde protein (GARP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875333.1">
        <property type="nucleotide sequence ID" value="XM_007877142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P3K8"/>
    <dbReference type="STRING" id="1069680.M7P3K8"/>
    <dbReference type="GeneID" id="19896950"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03263"/>
    <dbReference type="eggNOG" id="ENOG502SFYA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1835968_0_0_1"/>
    <dbReference type="OrthoDB" id="203678at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014812">
        <property type="entry name" value="Vps51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="140" mass="16268" checksum="1A5935DC55E96CE3" modified="2013-05-29" version="1">MNAYKGTSEKPSKNNQIKRTLREFYKLDTPIEFETRLPELDTDNFNLEEYIKETERNDPDKLLKLENTLIKEIRNLESEKKVLIYDNYRKLLSIADIIQKMKNGAESAKPIIDMLGPTLEHIGALSESLNHSPTEEDTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3N0</accession>
    <name>M7P3N0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875358.1">
        <property type="nucleotide sequence ID" value="XM_007877167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P3N0"/>
    <dbReference type="GeneID" id="19896972"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03285"/>
    <dbReference type="HOGENOM" id="CLU_600083_0_0_1"/>
    <dbReference type="OrthoDB" id="5345685at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="456" mass="51246" checksum="170B449E5BC3E102" modified="2013-05-29" version="1">MPYLNSSSLFEKDRISQTYVPRFVKPSNSRYSNISTQCLQISDKTSDFSIVQHNWKLSNLADVSSTDKINNLRVSTGSFVGGQIVSDRFDKLYASSPMPKLVNAAYFKLSNSLPCGESETSSVLKTATFSLGISEKIVQNSCHIIQQKQITHNAGPVKTCFGSSDFSSKFKKCDDSCNLLGKNDLNSISQNNQNVNIQKYNDHLKTLKRPSYLPPLKKVNTKYINLDSEKNIKNICNTESFSDVSKMDEIKYSSTKGIPYEQNPLAKNDFKVPFSGLFKTGINSQGSCVTNEPKCSAVSSYNDLSPEDISGNGKDNKSKEIYRRKGKKKSNGKAFNKSLTKRAPFSLTENELKNLSIFGGYISEEKLKRKRRPPRKWWLVSSNYSCDSSEKDKTFLTLEKKNGNSKLRSVKIENDRHICSNTMKLTGKHIYNSRAYAGNKQVNPNTVTINAYDFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3V9</accession>
    <name>M7P3V9_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_03031</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08550.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613289.1">
        <property type="nucleotide sequence ID" value="XM_019757749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P3V9"/>
    <dbReference type="STRING" id="1069680.M7P3V9"/>
    <dbReference type="GeneID" id="19896718"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03031"/>
    <dbReference type="eggNOG" id="KOG0772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014033_1_2_1"/>
    <dbReference type="OMA" id="KGDQYIT"/>
    <dbReference type="OrthoDB" id="10264376at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051858">
        <property type="entry name" value="WD_repeat_GAD-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017">
        <property type="entry name" value="GASTRULATION DEFECTIVE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="82"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="183"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="281"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="40"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="460"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="541"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="465"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08550.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="570" mass="64061" checksum="036140E978476DF6" modified="2016-03-16" version="2">MNYSPIQENKEFRELFPMSFGKRVYSENLEDAFKRTKREDADIQKIHKKNPLITKKQRDSSDSESNYEEEEDDFPISHEIVLKDHTKPISALSLDPSGTRIVSGSYDSNIKMWDFSGMSSTLNPFRTLEVVESQHVHYLEWNTTGDALLFISANSQAKILDREGEEISECVKGDPYLRDLKHTSGHISELTSGCWNPVSYERFMTSSVDSTVRLWNMNQPRKNEHIIVHKSKTPGKRMKVYSSTYSHDATFIATADNEGTLSLWAAKGPFHRPMGGTILNAHEKETHTSCISFLPSGNLMVTRGGDHTVKLWDIRKFKEPLSIRNQIENNYPETNIAFSPNGEYILTGSSIVTTTKDIGKLVILKTHNLEIVKELSIHNSAVIRTLWHTKINQILAGTANAAIHVLYSPKSSIKGAKLVLAKAPKIQHIDDDSSLTIDIYAGAVSGSIILPNGKLDETADTELTNARREKSMIRKDPIRSRIPSAPARNAPGGRGNNPDENHVKNSISLISMRDEDPREALLKYAELAEKDPIFTGIYKENQPNPIFADHTEDTTETIKHTKKNTLKPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7P568</accession>
    <name>M7P568_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleoporin Nup82</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02793</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874826.1">
        <property type="nucleotide sequence ID" value="XM_007876635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P568"/>
    <dbReference type="STRING" id="1069680.M7P568"/>
    <dbReference type="GeneID" id="19896482"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02793"/>
    <dbReference type="eggNOG" id="ENOG502QUNM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006117_0_0_1"/>
    <dbReference type="OMA" id="QFYHASK"/>
    <dbReference type="OrthoDB" id="341482at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037700">
        <property type="entry name" value="NUP88/NUP82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257">
        <property type="entry name" value="NUCLEOPORIN NUP84-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="656"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="795" mass="91196" checksum="F3E6BC9E3A77B289" modified="2013-05-29" version="1">MDDIYEYIFDENKWVHLLENHPIFSLSEKEQETIKNVKNKKSLIAVRQTEVFVGVDKTIRYADLKECKIDEHQKNRRMDYKEFKLKKITFHIEHLIINICGSILVVVGSHDLAIIFLPTYLNSLEENSLRVNEVGRKYYSQTEIVSVLFHPASKNFSTILVLSSDAIIRVFELSLSFEESEQSIDLITGTGRTRKKGSFVVEEDVFQVSDFCFDSKANEWSFFTLHVLLQNGDIYSICPLVPTNCMVQRSYLNRLACYISTKSQQLEKNKDDSTSVSLENESICMQTRWISDILGQVSLINDYGLGSPLSQNLDIQDLVTFRRPNISKFPVLIQGPFLFQPAPLEFSSEHVTASNIITLGTSIIGILVISYTDGKIDVCVEVERVEPRWVLNKNEQFPPLVNYLATYETITVLDSKNACDSAENDTLNTFLIQDVTKANTFYFYYKTSIYSVVLGWLEKLEKEDNIEVTSIAFLLSEGIQHSSISKLIDINSLSHSSPTIIGYDFLIHAYFGHSLIFWSTAFNCTLVELDITSQIQLENVMEESNSKNISVSGKNDHLKYFSLLTLPVYSVSLESLNFLKEAPSFIIPNEFQNKFVVSQEFLRFLGKVALETRKNTEKLHSLVVSMHRRLELQGREFIRQLEKLYILKNKVDSIVSKNSSERLKDAINNQKNLQKRADQILQKLIKSHSPTLSDNEKKWFDELKRIKMKTYGSKGFNEKILSLSKQFEAIKLGVYNNSAIDLSSKNKLHEPVTMSQINQIRLILDEQEQHISQTKSKLKKLSNILGAKSEIMEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M7P5J1</accession>
    <name>M7P5J1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_02492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874502.1">
        <property type="nucleotide sequence ID" value="XM_007876311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P5J1"/>
    <dbReference type="STRING" id="1069680.M7P5J1"/>
    <dbReference type="GeneID" id="19896185"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02492"/>
    <dbReference type="eggNOG" id="ENOG502S2AU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081626_1_0_1"/>
    <dbReference type="OMA" id="ILYNAEP"/>
    <dbReference type="OrthoDB" id="2093493at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22849">
        <property type="entry name" value="NuzM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016813">
        <property type="entry name" value="NADH_Ub_cplx-1_21kDa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37325">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G05910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37325:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G05910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022976">
        <property type="entry name" value="NADH_Oxi_21kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR09150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="171" mass="19821" checksum="C3A09533D9BEDBB9" modified="2013-05-29" version="1">MRQKFVKLTVENKKYFWNWLRRLLVIDPERSSGITYNNQYRKPAPGSPERLYARPLNLPASDISENSYWKRDMRRNYPRPGIITQPILAKLFVLGSVENPKISEPSETEAQTTTPAITQSLSTILYNAEPSEIRKFVLTDKGIAPHPGNSYHWTLDEKNGYPSTYSVRTFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7P5L9</accession>
    <name>M7P5L9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="10">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_02515</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="10"/>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874525.1">
        <property type="nucleotide sequence ID" value="XM_007876334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P5L9"/>
    <dbReference type="STRING" id="1069680.M7P5L9"/>
    <dbReference type="GeneID" id="19896207"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02515"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_9_1_1"/>
    <dbReference type="OMA" id="PVDIVYC"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF189">
        <property type="entry name" value="CYTOCHROME C MITOCHONDRIAL IMPORT FACTOR CYC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4 9 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="39"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR09175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="289" mass="33663" checksum="64FF65042378E616" modified="2013-05-29" version="1">MFFSVSKRIKFMSACFGIFSVGVLYSYVNSEKRDYLNGDFYSFCTIRDIRQISPSTNIYELEFDRPSKQYQNRPIQNVLLKNSDIQIQRYYTPIYISSRKVVLLVKFYEDGEVSRWIHRKRVGDRIELRGPFLEWKWNDNQWKNVLFIAGGTGITPAYQLLSYIFQDGVQYMPKFHLMYANRNPDEILLRKELDNLQEKYSENLKITYFVDSSPDSKVLDKYLIRSINLYDIIQAFPSSGCTDSDTIVLVCGTDGFVSYIAGPKDTLYGEQGNLGGLLKKAKCLNVWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7P647</accession>
    <name>M7P647_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02277</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874269.1">
        <property type="nucleotide sequence ID" value="XM_007876078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P647"/>
    <dbReference type="GeneID" id="19895970"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02277"/>
    <dbReference type="HOGENOM" id="CLU_750311_0_0_1"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="110"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="110"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR09320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="369" mass="41905" checksum="940790598ECF553C" modified="2013-05-29" version="1">MKTKSPEFMSQCRVLNFPWMNKRMRRSKSEYKTVSGQAEYSQVLMFQPPSVEVESGVNKSPFPVIQMMDGKEPFIWEDGQTKFSDIPKEMTQTKSSCSRTSVKSVSKNRIPRPKNAFILYRSHVSQLLKETMTFKVRESNISSLVSEMWKKESDVVHAYYARRAALEWVKYMKRVQQQRCSLNTDESEIRSPTPPVPLRNEPSFSPEPCPNIVSYTQPSFSSPTQTSVQENSVVTSYDDPFIGTMLYNSSPDTSNLGFVNTDPSVRLSSSPQSSNGDILDPTYKDNIPTGNSGYLFLDKSCVPLSFKDFLFSYNMNQLDTNCAYTFNSSTPVFPTNTYPCMIDTGLGMDTNIRWPGLMQTSTPWPVNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6Q3</accession>
    <name>M7P6Q3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02151</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874132.1">
        <property type="nucleotide sequence ID" value="XM_007875941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P6Q3"/>
    <dbReference type="STRING" id="1069680.M7P6Q3"/>
    <dbReference type="GeneID" id="19895844"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02151"/>
    <dbReference type="eggNOG" id="KOG1547">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017718_7_1_1"/>
    <dbReference type="OMA" id="QCEFVYL"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032161">
        <property type="term" value="C:cleavage apparatus septin structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043934">
        <property type="term" value="P:sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000260">
        <property type="entry name" value="Cell division control 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="7">
        <location>
            <begin position="42"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="338" mass="38371" checksum="AB5455D13E08B2B3" modified="2013-05-29" version="1">MSGVIAPRNSSMAPYVKGPIQSSGYVGFDSITKQIERKLIRRGFQFNIMCVGQTGLGKSTLVNTLFAAHLMDSKGRLNSEEPIRQTTEIHSVSHILEENGVNLRLNIVDTPGYGDLVNNERCWDPIIKYIKDQHSSYLKKELTAQRDRYIQDTRIHCCLFFIQPSGHSLKPIDIIVLKKLVNVVNVVPVIAKSDSLTLDERIAFKKRIREELNFHGIRTYPYDSEESSDEERALNSQIKNIIPFCIVGSEKTIAVDGKIIRGRQNRWGVINIENENHCEFVYLRNFLARTHLQDLIETTAQIHYENFRSRQLLALKESSAMGSGPRPITRGSMGDNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7P7I0</accession>
    <name>M7P7I0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="5 7">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01986</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = (6R)-5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="5 7"/>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873966.1">
        <property type="nucleotide sequence ID" value="XM_007875775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P7I0"/>
    <dbReference type="STRING" id="1069680.M7P7I0"/>
    <dbReference type="GeneID" id="19895680"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01986"/>
    <dbReference type="eggNOG" id="KOG3093">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066245_2_1_1"/>
    <dbReference type="OMA" id="HEDGLAF"/>
    <dbReference type="OrthoDB" id="2015992at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407">
        <property type="entry name" value="ATPASE INHIBITOR/5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="82"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="144" mass="16448" checksum="231F755B31C30166" modified="2013-05-29" version="1">MNFICNNQKGKKIYVPFVDGQEMFMFCLYSAEDPSTFVKNKWGIPQPSKSYVKGIIREEAMDKDGLDLIIIPGIAFDRNLNRLGHGKGYYDKYLTKIKHWSEKSNLSAPLKVGIALKEQLVDIVPINSLDVKLDILLVENEIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7P7X7</accession>
    <name>M7P7X7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01738</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873702.1">
        <property type="nucleotide sequence ID" value="XM_007875511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P7X7"/>
    <dbReference type="STRING" id="1069680.M7P7X7"/>
    <dbReference type="GeneID" id="19895432"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01738"/>
    <dbReference type="eggNOG" id="KOG2189">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005230_0_2_1"/>
    <dbReference type="OMA" id="FYLWFFL"/>
    <dbReference type="OrthoDB" id="10264220at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="542"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="633"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="755"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="821" mass="95157" checksum="5BE8A0E00B2493FB" modified="2013-05-29" version="1">MASSTFYRSEEISMVQFYFPVEVAKLTVSALGDLGIVQFCDLNENINIFQRAFVKEIRRLDEVERQLQFLYEEIKKTDIKIITADNNDNMTRTSNCHEIDEIFEKASFFESRICSLNESYRTLEKQYLELLELRYVLEETEQFFNKNYSIQESSISINDMDTAPLLENDAEQNTTNIQGLMGMSIGFTTGVIPRIHMATFERILWRMLRGNLYMNQTEIANPINDPITNELIDKNVFIVFSHGKEINNKIRKISESLGATLYNIDERYSRRCTHIQETNLAIDDLMSILKNTKQTVYAELRIIAENIVNWITIVRRERAIYQIMNLFIYDQNHKCLISEGWCPTNSLYLVRNTLRDVTEQACIQMPSILNEIKTSKTPPTFHSTNKFTKAFQTIIDAYGVASYREANPGLIAIVTFPFLFAVMFGDLGHGFLIFIAALYLCLNEKKLEKKKYGEIFDMAFQGRYMILLMSIFSMYTGLIYNDIFSKPMSLFKSGWEWSESSGNSTVILAKKVGVYPFGIDSAWHESENALIFLNSYKMKMSVILGVIHMTFSLMLSLTNHIFFKSPLDIWTQFLPSFLFLQCIFGYMVFTIIYKWSVDWSKSQTTPPGILNMLIFMFLSPGKIQEPLYRGQKYVQVFLLFISLICIPWLLLAKPFVLRYEHRRAILQGYQGVSNRCSSTLDDSDTDRTPLSSEVHEHFDFVEILIHQIIHTIEFCLGCLSHCASYLRLWALSLAHNQLSAVLWSMTLKIAFRKTGITGAILLVFVFAFWFISTIVILCLMEGTSAMLHSLRLHWVEAMSKFYQGEGYPFEPFHLTNKFYDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7P7Y2</accession>
    <name>M7P7Y2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL39</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L39</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01743</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873707.1">
        <property type="nucleotide sequence ID" value="XM_007875516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P7Y2"/>
    <dbReference type="STRING" id="1069680.M7P7Y2"/>
    <dbReference type="GeneID" id="19895437"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01743"/>
    <dbReference type="eggNOG" id="KOG0002">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181948_3_0_1"/>
    <dbReference type="OMA" id="RRTKMNI"/>
    <dbReference type="OrthoDB" id="6332053at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1620.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein-like L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.10">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00629">
        <property type="entry name" value="Ribosomal_eL39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000077">
        <property type="entry name" value="Ribosomal_eL39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023626">
        <property type="entry name" value="Ribosomal_eL39_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970">
        <property type="entry name" value="RIBOSOMAL PROTEIN L39E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00832">
        <property type="entry name" value="Ribosomal_L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48662">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="51" mass="6480" checksum="76DA5BBA189A473E" modified="2013-05-29" version="1">MSSHKTFRRKIILARAQRQNRPIPQWIRLRTNNRIRYNAKRKHWRRTKLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M7P824</accession>
    <name>M7P824_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Asparaginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_01779</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Asn) + L-asparagine + ATP = L-asparaginyl-tRNA(Asn) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873747.1">
        <property type="nucleotide sequence ID" value="XM_007875556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P824"/>
    <dbReference type="STRING" id="1069680.M7P824"/>
    <dbReference type="GeneID" id="19895473"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01779"/>
    <dbReference type="eggNOG" id="KOG0555">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_10_1"/>
    <dbReference type="OMA" id="DCCLYPR"/>
    <dbReference type="OrthoDB" id="1931232at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04323">
        <property type="entry name" value="AsnRS_cyto_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1910.20">
        <property type="entry name" value="asparaginyl-tRNA synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048952">
        <property type="entry name" value="AsnRS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF16">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20917">
        <property type="entry name" value="AsnRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="257"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR10025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="560" mass="63944" checksum="192A5D224C7570C4" modified="2013-05-29" version="1">MSEKQDFKGEKNCLYIDEISGSDELGVGSIENPFKTAVKALEIGGEESLIYIRKSAGEEYKEITQTSLKKAKKSLCILLKKKQKLDDAFSHMKVQDENSGEIEKLKQAEKIVIEKNKSLDEAVRIRIRDSKLYKDTVVQISGWVHRLRHQKELIFIILRDGTGYLQCVLGGKIAQTYDSLTLTLETTLTVYGTITSLPDGKIAPDNHELNVLYYEIIHKAPGGDLSFANKLNVESESQVIYDQRHLVIRGEASSSVLKVRSYLLSAFRKVYEKMGFVEVTPPCLVQTQVEGGATLFDLNYYGEKAYLTQSSQLYLETCLPSLGDVYCLQESFRAETSHTRRHLSEYSHLEAELMFLSFDEFLSHIEDFLCLSLDILLDNSLARSLIEYLNPRFEKPQKPFLRMKYEDAIKYCNEHNILNTNGELHVFGDDIAEAAERRIVDEIQKPIFLIHFPASLKSFYMKRIPGNEVLTESVDLLLPGIGEVVGGSMRISDYDELKKAFEREKIDVGPYYWYLDLRRYGSCPHGGYGLGLERILAWLTNRNTVKECCLYPRFTGRCKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7P8L5</accession>
    <name>M7P8L5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipid scramblase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01473</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phospholipid scramblase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873412.1">
        <property type="nucleotide sequence ID" value="XM_007875221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P8L5"/>
    <dbReference type="STRING" id="1069680.M7P8L5"/>
    <dbReference type="GeneID" id="19895169"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01473"/>
    <dbReference type="eggNOG" id="KOG0621">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023808_0_2_1"/>
    <dbReference type="OrthoDB" id="191150at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017128">
        <property type="term" value="F:phospholipid scramblase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005552">
        <property type="entry name" value="Scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248:SF9">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03803">
        <property type="entry name" value="Scramblase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="335"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="410" mass="47235" checksum="4252DC219B3D5534" modified="2013-05-29" version="1" fragment="single">MVCLRWLKRAKRIDFKVRFYAIRAFPACLSPLSRFSRIYNPHDSIRIEKLGKSQAERSKQVEVRLKEDPYGVLRHSVALLNILGNSTLVIQRKMEMMNVFFGFEQANKYIVMDSSGKHVGYIAETGDQSITKIFARQIFRTNRAFKAHILDREGNEVLLIERPFSWINSKIRVIDRMDSSYPIVGEVQQQWHAWRRKYNLFLKRNDIFSQFAYIDEPLFSWDFSLMDQEGGLIGSVNRNFMGLFQEMFTDTGNYVLRMDSVSETNETASSKQLINVNGRTDVLAPLKRGLTLDERAIILATAICIDFDYFSKLSKGGASIGSFFPFWFPVFGGGTHENSTEQPESTSTSQDQDSSLSSNDEPSKSEETEKKWWDLSPDNDVWGEGDHDPWSDSNQNQDNDSWGGFFEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M7P8Y6</accession>
    <name>M7P8Y6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Terpene cyclase/mutase family member</fullName>
            <ecNumber evidence="7">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_01548</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="7"/>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873495.1">
        <property type="nucleotide sequence ID" value="XM_007875304.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P8Y6"/>
    <dbReference type="STRING" id="1069680.M7P8Y6"/>
    <dbReference type="GeneID" id="19895243"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01548"/>
    <dbReference type="eggNOG" id="KOG0497">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CWARQTI"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000250">
        <property type="term" value="F:lanosterol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02892">
        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000003">
        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002365">
        <property type="entry name" value="Terpene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF20">
        <property type="entry name" value="LANOSTEROL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01074">
        <property type="entry name" value="TERPENE_SYNTHASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Squalene cyclase N-terminal" evidence="9">
        <location>
            <begin position="80"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase C-terminal" evidence="8">
        <location>
            <begin position="382"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR10285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="719" mass="83177" checksum="54223FFD9F611719" modified="2013-05-29" version="1">MFYEDIEKKLEKTDPYGWRLIVEDTGRQRWKYLKTKKEREEMPQTNMEKYFLGLNMDVPELPLAKTPIESARNGFLFYKHLQTKEGNWACEYGGPMFLLPGLIIAMYISKIPFSDEMRIEVIQYLVNHANPKDGGWGIHIEGKSTVFGTALNYVVLRILGLGPDHPVTMKARIKLNELGGAIGCPQWGKFWLAVLNCYSWEGINPILPEFWMLPEWFPIHPSRWWVHTRAVYLPMGYIYGEKFTAPLDPLIESLREELYTQPYSSINFSKHRNTVSSVDVYVPHTTFLRVINSILTFYHTTFRLSWIKNIASKYTYELIEYENKNTDFLCIGPVNFCIHILAVYWREGPNSYAFKSHKERLTDFLWVSKKGMMMNGTNGVQLWDTSFAVQALVESGLAEDPEFKDSMIRALDFLDKCQIQKNCDDQQKCYRHQRKGAWPFSTRQQGYTVSDCTAEGLKAVLLLQNLKSFPKKVSYDRLKDSVDVILSLQNKDGGFASYELIRGPSWLESINPAEVFGNIMIEHSYTECTTSVVTALCYFRSLCSHYRGSEINKSVKKAIQFIKESQRPDGSWYGSWAICFTYATMFALESLSCVKDFYENSFHSRRACDFLLNKQEKDGGWSESYQSCTDGIWTRHPNGSQVVQTAWACIGLMYANYPDKTPIKRGIDLIMSRQQSNGEWKQEAIEGVFNKNCMISYPNYKFNFTIKALGMYSKRYGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7P909</accession>
    <name>M7P909_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Guanine nucleotide-binding protein subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01572</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873525.1">
        <property type="nucleotide sequence ID" value="XM_007875334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P909"/>
    <dbReference type="STRING" id="1069680.M7P909"/>
    <dbReference type="GeneID" id="19895267"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01572"/>
    <dbReference type="eggNOG" id="KOG0286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_34_1"/>
    <dbReference type="OMA" id="PLDSQWV"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000020">
        <property type="entry name" value="Guanine nucleotide-binding protein beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="57"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="145"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="186"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="229"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="315"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="347" mass="38466" checksum="882632EC3BBA82D3" modified="2013-05-29" version="1">MTTRDLQDKISAACKEAEYLKEKIKKKKDELADTNLRSMAQTLNAVTRIPIRVRHTLKGHLAKIYAMHWSTDQKHLVSASQDGKLIVWDAYTTRKTYAIPLRSSWVMTCAYAPSGNFVSCGGLDNVCTIYDISSKDGRAKIARELMAHTGYLSCCRFLSDEQILTSSGDMSCILWDINTGSKIQEFLDHLGDVMSLSIHPTNPNLFVSGACDAFAKIWDIRTGRPVQTFAGHESDINAVQYFPNGNAFATGSDDASCRLFDVRADRELNRYSAANIMCGITSISFSISGRLLFAGYDDFNCNVWDVLRGNRVGILQGHDNRVSCVGVSKDGRSLATGSWDSLLKIWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7P9B3</accession>
    <name>M7P9B3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="11 12">3.2.1.106</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glucosidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PNEG_01159</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="13">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="11 12"/>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873074.1">
        <property type="nucleotide sequence ID" value="XM_007874883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P9B3"/>
    <dbReference type="STRING" id="1069680.M7P9B3"/>
    <dbReference type="GeneID" id="19894856"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01159"/>
    <dbReference type="eggNOG" id="KOG2161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007380_1_0_1"/>
    <dbReference type="OMA" id="FNWYNTT"/>
    <dbReference type="OrthoDB" id="410058at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070880">
        <property type="term" value="P:fungal-type cell wall beta-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16923">
        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="15">
        <location>
            <begin position="41"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="14">
        <location>
            <begin position="297"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMR10445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="787" mass="92971" checksum="F70CACB6AE66DE42" modified="2013-05-29" version="1">MIFYGKLVFIILLIKEWILIYTKANVSEWLAKEVEIAENASLFWGPYRPNLYMGIRSRDPEGMLMGIMWMAVDNYTQIREIRHTCEQNHNIKMYGWEEFDVRKGGRQIIKDDEMNVEIEIGFAKIYTEKHNGNWGLRIKGKPKNVYNKISIFFYIASSNDEIKLISELGKEGVKGNVVFMNKISKKKNIEITQGPSTNTYPLFTHTAENEKHLDRFMYHSMKVPKKEMWMAKDLLYSVLILTTRDYYKKYNEDIPPAALYYTLPNIDEEGNFHFVQRVFQGPFEFDILYSSTDDPMTSHQLENEIISNSKLFKERFMKIFSFKDPFNSDKYIEFAQNLLSNLLGNIGYFYGDSIVDRTYSYEYQEVFEEYDSYVSPQIQGPFSLFTTTPNRSFFPRGFYWDEGFHLLLIGHWDNDLSLEIIKSWFSLIDDDGWIAREQILGDESRSKVPKEFIIQYSYCANPPTLILPIISFLEKLEQNNRNETDQDNKKENIYSKYIKYPELAIDYLKKIYPLICRQYNWYRRTQQGEIEEWNRNASSPNEGYRWRGCTPQHCFASGLDDYPRAYPHNGELHLDLLSWMGLFTKGLKIIAEKIGYQEDVEKYKSIENAIIKNIDDLHWSDEHNAYCDCTIDKKYLSIHECHIGYVTIFPLLTGLLSASSPRFDKLLDIMYSSDHLWSSYGLRSLSTKNPYFEKDENYWRGPIWININYMALQSLYKNYINTPGPYQEKAKKIYHELRINIVNTVFNEWKRTNFAWEQYNQASGAGQRTKGFTGWTSLIVNILSEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAW0</accession>
    <name>M7PAW0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872513.1">
        <property type="nucleotide sequence ID" value="XM_007874322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PAW0"/>
    <dbReference type="GeneID" id="19894313"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00615"/>
    <dbReference type="HOGENOM" id="CLU_1468780_0_0_1"/>
    <dbReference type="OrthoDB" id="5399812at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009563">
        <property type="entry name" value="SSSCA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06677">
        <property type="entry name" value="Auto_anti-p27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="184" mass="21460" checksum="BC4C2D718C8CA865" modified="2013-05-29" version="1">MNFNNSNDSKTLFSACFFCLLILEYPQFKKSYTDDVPKLLSSKLLMGWALLDDYCNNHFVPLMRSPHNKLLKECVLCVEEQEQYNNMQLNREMRTIDKCFEKKENNNNEKDNISSFSCNDYSARLSEWLQILDHASNNIFSSLKKCSVAISSANVELELHLISKIKLCVETLESLERCKTYLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M7PB64</accession>
    <name>M7PB64_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CSN8/PSMD8/EIF3K domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872627.1">
        <property type="nucleotide sequence ID" value="XM_007874436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PB64"/>
    <dbReference type="STRING" id="1069680.M7PB64"/>
    <dbReference type="GeneID" id="19894424"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00726"/>
    <dbReference type="HOGENOM" id="CLU_1066050_0_0_1"/>
    <dbReference type="OMA" id="WTWEKLV"/>
    <dbReference type="OrthoDB" id="2100128at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398:SF1">
        <property type="entry name" value="CSN8_PSMD8_EIF3K DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398">
        <property type="entry name" value="YALI0F14311P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="31223" checksum="7E0A006B9600863F" modified="2013-05-29" version="1">MSNQKDKRWLDSFGLISKGNDNRLKDPKIHEIFYKRLKRHYATLIDRVNNDTLEDSFSNLTLNDQTLSLNEQQHCLYLFRQLREGITASQRIDNFTCGLYETSVRVGIYMNHVESYVPALCYLLEVIYPKLLKPFAQNQMVTCYLLYLCSLRNFQGLYEMKNKWELDAQDIPFEFSKILIQNNYIAWWKLRQRVPWLYQRLIDLSREQIQERCVSVIKASYYKITKKWMETYIGLALFSKTGWIIEDSWIKIREPGLPKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7PBR5</accession>
    <name>M7PBR5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pre-mRNA-splicing factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00334</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Belongs to the 40S cdc5-associated complex (or cwf complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWF11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872207.1">
        <property type="nucleotide sequence ID" value="XM_007874016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7PBR5"/>
    <dbReference type="GeneID" id="19894032"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00334"/>
    <dbReference type="eggNOG" id="KOG1806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001195_0_0_1"/>
    <dbReference type="OMA" id="YRVWLDC"/>
    <dbReference type="OrthoDB" id="1879at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002863">
        <property type="entry name" value="Pre-mRNA-splicing factor cwf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048966">
        <property type="entry name" value="Aquarius_b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048967">
        <property type="entry name" value="Aquarius_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032174">
        <property type="entry name" value="Aquarius_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026300">
        <property type="entry name" value="CWF11_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF5">
        <property type="entry name" value="RNA HELICASE AQUARIUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16399">
        <property type="entry name" value="Aquarius_N_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21143">
        <property type="entry name" value="Aquarius_N_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21144">
        <property type="entry name" value="Aquarius_N_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038901">
        <property type="entry name" value="AQR_cwf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA helicase aquarius N-terminal" evidence="5">
        <location>
            <begin position="15"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="RNA helicase aquarius beta-barrel" evidence="6">
        <location>
            <begin position="462"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="RNA helicase aquarius insertion" evidence="7">
        <location>
            <begin position="688"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="3">
        <location>
            <begin position="780"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="4">
        <location>
            <begin position="1083"/>
            <end position="1274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR038901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR11305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1349" mass="158049" checksum="4B6082ABA6048F48" modified="2013-05-29" version="1">MNSMINEGKLSEWSVKEEFDREKVEEIYIYLEKMRFNEKILLYLEESCYLERYLWKYMNDESTDNHIYSICILSVYKKSSGKPWDFISDKPSFFSFFFKRVLEHAFLDSKKAILRTYLLSFIIISFQLFDNDVIRKECTSLISIDIWANLSSKETIKSRISMHPHLQKQWKASVKKFNSSYNETLLKKKFYRDWLFNIIIDFINLLYNVKNNEHLIYCEKVLELLIDLLSQPLSRRYLNFLLKDFHFTALVKKSPMYMISENYVFKSLFSILDEYIYIGYDDHNSVELSSEKITEIHYNKIAKLQRIAMKEYKEKLIILATSNYATIDTGDTLIEHLEGLDDNEFYELFQHIGLRSQYPKELLVPIDREFLTLALIEYYKRRKSLQEIFEDFLVIPDEKSLFSLKFHFYKKYNGIRSLPLLKFNLQYLSINDFIYRSLQFYRDKVYDEIHKDIEQVISRLKPKVQYPSFTIRFQGNSNMALIIKHLAILEVSPPKVGEEKPGFVRAEVKLELDNITEELRRQWESLHPGDIVYLLSIKPIDDLKETPEMNVSFSLKSGLRYLRIAQVDQILNYDGRPLKVVEQLAQEDEFEMVKTGRKRILRLFLDTHNYKIDNDGVLYHNKDDVYASINVIVRRSPKETNFKLILESLKSLTRTSISLPSWFEDIFLGFGDPSSALYYNLNAPLNLFFPDTFFDWNHLLECFPNKNIKLIPSEKYNSAPNPPYRIYSGSIPSLENSCELNNGLENKSDNVLYVETYNFLNPGPYLQNKKKNNKIRFTPKQVEAIYSGTNPGLTLINGAPGTGKADIIAQIICNIYYNFPDQRTLLIAHNSQALIKVFEKLSLLDIPQRHLLRLGHEDELEDEFISRRPGRINLFLERRASLLLEVDRLALTLQIPGAHGNSCETAGYFFDFYVKPLWTNFISNSKNESSVKEIISSFPFHQYFSTAPQPLFPEDLNKHETLDIAKGCYNHIKELFSELSDIRPFEFLHSNEARSNYLLNKAKIIAMTSSYLLTKREKIFDLKFKYNTIIYKNSNQLLEIETFVPMTLMTNFESLQRIVLLGDYKQMGPILKNKAFRYFCNAKQSFYDRLIRLGVPIIHLDAQGRAKNTIAELFSWAYGGLANLPNIEKQSEFLYSNSGFLFDYQFINVGDYKGQGETEPTPYFYQNLGEAEYAVAIYQYMRLLGYPSEKITILASYTGQKALINDVINRRCANNPLFGLPNKITTIDQYQESYNDYIILSLTRTKSLGYLKELERLIVAVSRARLGLYILGRRSIFESCFELKPIISRVLKNPDKLHLVSQEMWPSNRKIGDKVENTFVMEGVEHLGIYVYKMSEKALEKLKENKDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M7PBZ2</accession>
    <name>M7PBZ2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anaphase-promoting complex subunit CDC26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872301.1">
        <property type="nucleotide sequence ID" value="XM_007874110.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PBZ2"/>
    <dbReference type="GeneID" id="19894121"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00423"/>
    <dbReference type="HOGENOM" id="CLU_2590747_0_0_1"/>
    <dbReference type="OrthoDB" id="5284455at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018860">
        <property type="entry name" value="APC_suCDC26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10471">
        <property type="entry name" value="ANAPC_CDC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="9387" checksum="CD5ADE2BD0AD67EB" modified="2013-05-29" version="1">MLRRPPTVIRLVQEDIFEYDDIRAQEKAASHAGKSIALRDKDMDTMHIMTEGFILQDRRKDVTKNERIGLSMSRIQETRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7PC85</accession>
    <name>M7PC85_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-C homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_03529</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-C/MIF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875621.1">
        <property type="nucleotide sequence ID" value="XM_007877430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PC85"/>
    <dbReference type="STRING" id="1069680.M7PC85"/>
    <dbReference type="GeneID" id="19897216"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03529"/>
    <dbReference type="eggNOG" id="ENOG502S47H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027966_0_0_1"/>
    <dbReference type="OMA" id="RDIHNIP"/>
    <dbReference type="OrthoDB" id="1939643at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019237">
        <property type="term" value="F:centromeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051455">
        <property type="term" value="P:spindle attachment to meiosis I kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06993">
        <property type="entry name" value="cupin_CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000033">
        <property type="entry name" value="Centromere protein C 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028386">
        <property type="entry name" value="CENP-C/Mif2/cnp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025974">
        <property type="entry name" value="Mif2/CENP-C_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028929">
        <property type="entry name" value="Mif2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684:SF11">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11699">
        <property type="entry name" value="CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15624">
        <property type="entry name" value="Mif2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mif2 N-terminal" evidence="9">
        <location>
            <begin position="21"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Mif2/CENP-C cupin" evidence="8">
        <location>
            <begin position="471"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="275"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00057947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00075033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF15624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR08089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="567" mass="64022" checksum="402A58075C059E42" modified="2013-05-29" version="1">MIWGSGSTRVPGSSGCPNAKFMDIGVVGRKTGLRIHDSVQRDSFGMEDMDAFFSPSTPPSVDETVASGWEVSRKNDQTISLEQSMDVSQGLPQNASDIIVTRKLSNSWIERNPLEALAGRRVLKGESPWIGRSPTKTNLNSPALRIPSTQKREPVLSPTRLDWSDGVARRLDFSATAAIDDESEEQDKPAPLVVKSVKRGQLMQQKKKQKTFSLMDNLENSESDQQDDAQDFIHNDAQDWENSLKYEIEDKSTEESDNKLNRKYKKGVSIRKKKVDNDVSLKKRKISQVPLKSKKFSSNHFPKKRSLSSRSSTESPDASSKMVMKTKLDKKQPRCVPSEDLLSSALSPHVNGTRRSLRTKVAPLAYWRNERIVYELGERRKSGPAMPKIKEIIRVDPISIPNRHKGTSRTKNTNFKKKLIKSEMPSDDEWEEKVDVECEVINWHDKKPIVKRIAYPASSYAPKDVANAIIKFQKTFDEAPFFATGVMDLPRGGEKATKPSKHNVMTFVILEGAVEATVHQTSFRLKRGSHFIVPRGNYYSIRNIANKVSRLFFTQATDTLENEELRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCH9</accession>
    <name>M7PCH9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_03347</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875427.1">
        <property type="nucleotide sequence ID" value="XM_007877236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCH9"/>
    <dbReference type="STRING" id="1069680.M7PCH9"/>
    <dbReference type="GeneID" id="19897034"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03347"/>
    <dbReference type="eggNOG" id="KOG0381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2498794_0_0_1"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01390">
        <property type="entry name" value="HMG-box_NHP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="25"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="25"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="86" mass="9791" checksum="E3B954D8C5BD35D7" modified="2013-05-29" version="1">MPKDAKSRGIKKVSGKRVKKDPDAPKRGLSAYMFFAQENRELVKTENPDATFGQIGKILGERWKNLSSKDKQVILLDLCSFFNVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCJ3</accession>
    <name>M7PCJ3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_03356</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>glycerol + ATP = sn-glycerol 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875438.1">
        <property type="nucleotide sequence ID" value="XM_007877247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCJ3"/>
    <dbReference type="STRING" id="1069680.M7PCJ3"/>
    <dbReference type="GeneID" id="19897043"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03356"/>
    <dbReference type="eggNOG" id="KOG2517">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_2_3_1"/>
    <dbReference type="OMA" id="HKTDATN"/>
    <dbReference type="OrthoDB" id="5422795at2759"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07792">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK1-3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000177">
        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000108">
        <property type="entry name" value="Glycerol kinase, glycosomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042018">
        <property type="entry name" value="GK1-3_metazoan-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000756">
        <property type="entry name" value="PRK00047.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF69">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 12 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="13">
        <location>
            <begin position="11"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="14">
        <location>
            <begin position="272"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR08184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="514" mass="56857" checksum="4843F34D9F35C886" modified="2013-05-29" version="1">MSFNSKMFSEYIGAIDQGTTSTRFLIFDRTGSIVSLHQHEFKQIYPHPGWIEHDPMEILESVEICIRKTIEDFVKKNKSVRQIKGLGITNQRETIVVWDKDTGKPLYNAIVWSDTRTIEVVRELKQKEDASEVHKICGLPISTYFSAVKLRWLLDNVRSVREVYDSGRLAFGTIDSWLIYNLTGNIDGGIHITDATNASRTMLLNIRTLEYDESLINFFGLEKLHLPKIKSSSEIYGEISSGPLCGTPLSGCLGDQSAALVGHLAFTPGSAKNTYGTGCFLLYNTGETPVISKEGLLTTVGYFFKGQKPVYALEGSIAVAGAAIKWFRDQMGVITEASQIDEMAASVEDTAGIVFVTAFSGLFAPYWRDDARGTILGITNYTTKEHIARSILEAICFQTKAILDVMNRDSGSPLKCLNVDGGITNSDICMQIQSDIVGIDVNRPQMREVTALGSAIAAGLAVGVWKNVEELQSVSAGKTFVFSPKISEDKRNRMFCLWEKAVQKSLDWETGKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCP7</accession>
    <name>M7PCP7_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_03402</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875487.1">
        <property type="nucleotide sequence ID" value="XM_007877296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCP7"/>
    <dbReference type="STRING" id="1069680.M7PCP7"/>
    <dbReference type="GeneID" id="19897089"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03402"/>
    <dbReference type="eggNOG" id="KOG0796">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030397_1_0_1"/>
    <dbReference type="OMA" id="CPYDLFQ"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="237"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="85"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="276" mass="31836" checksum="1C7DA508D343BC5B" modified="2013-05-29" version="1">MASEQRKLLEQLMGSDMMGSSHQQTMSFTSPKVCRSFLCGDCPHDMFTNTKMDLGPCSKIHSDKLKADYQKARLKKDYGFEYDYLRDLNKYIDDCNRRIDSAQKRLEKTPEELAKASQLARDMAELEKIIDTALEEVEVLGEQGEVMRAVEEYHKVEKYKIDRSEREKELKSISTNSGSLGHQKLQVCDVCGAYLSRLDNDRRLADHFGGKLHMGYSKMRSLVIELKKELDLKKNNGSNYNSLDALEENEQNYSSRSTKGRSRNYKKGSFDDKYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCS8</accession>
    <name>M7PCS8_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872005.1">
        <property type="nucleotide sequence ID" value="XM_007873814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCS8"/>
    <dbReference type="GeneID" id="19893842"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00144"/>
    <dbReference type="HOGENOM" id="CLU_1005170_0_0_1"/>
    <dbReference type="OrthoDB" id="5383441at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="86"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR11710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="277" mass="32575" checksum="A5878A4A741AC98A" modified="2013-05-29" version="1">MIEDLSSIFLQDSLKQLGLTMHKEGSHGILPTSELQKDFLYNGHNNNLSKCPQSEQKQGISQSLEIWAKKIYYQSDDLQRLIQKNSEKYLERHEELERLIKEFRSDCYAWLESAKEEHKARENEIMEKQENFRRICNIISDTIKANECKIHKLESMVEQLLSIIIAQEAKFLTFEAKQSENLKPLHLTMNQILNAINQRQTDQHQNDHYPMNPPSEKQNTGNKDTIPSFVKTNTRKRILLTSDELKDLGKTLNEYKEDKKQVIPLRKNINRTHSKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M7PCY5</accession>
    <name>M7PCY5_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_03147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875207.1">
        <property type="nucleotide sequence ID" value="XM_007877016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PCY5"/>
    <dbReference type="GeneID" id="19896834"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03147"/>
    <dbReference type="HOGENOM" id="CLU_883151_0_0_1"/>
    <dbReference type="OrthoDB" id="5392499at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="315" mass="35016" checksum="3ED1770694604993" modified="2013-05-29" version="1">MDPSLTVQDCGHKRTHRRSGAVSLDLGFKGIFSNSKDLGKASSSTLDEAIHDPGSCTVKQKKQDNTEELLVLPNARTSKKRIGFHGWFWAESILSLAYLYFGGSHKKKVSESSGPVVLNVEEHAPPSSICKVTLQPLIDLDAALLTKPNSSLFTASEKFQRPRSATVSSPYFSESGSTYHSSYRNGYTLKRKMSVIIEDADMISTSLLPSSERVSNTLQNVQTATEQSMQVVPTDGKEANVFEKEDIGLNSSKNVLNDDKSIVDIYDFFPVSHVGDTINHDNTLIKMNEQGISKSIKGKWKWRRILGKFLKQRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7PD52</accession>
    <name>M7PD52_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMMECR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872105.1">
        <property type="nucleotide sequence ID" value="XM_007873914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PD52"/>
    <dbReference type="STRING" id="1069680.M7PD52"/>
    <dbReference type="GeneID" id="19893934"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00236"/>
    <dbReference type="eggNOG" id="KOG3274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052828_1_0_1"/>
    <dbReference type="OMA" id="TNEAFPL"/>
    <dbReference type="OrthoDB" id="24630at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="entry name" value="Hypothetical protein ph0010, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00296">
        <property type="entry name" value="TIGR00296 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016:SF0">
        <property type="entry name" value="AMME SYNDROME CANDIDATE GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="AMMECR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="AMMECR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="1">
        <location>
            <begin position="25"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="238" mass="27842" checksum="54C4B720ACF996BA" modified="2013-05-29" version="1">MFKYFLNGESNPDLSERIYLATVRIFFSFEIAEISHCVYCFDVLIDYFDKNHFPGRELIRKDYNDTSHMPTNRSFLNNDILFPLFVTWNIISSSGHKSLRGCIGTFKPQPLKHGLRYYALTSALNDTRFPPISEQEFILFGVTLLTNFEIIEDPLDWIIGIHGLQISFFYKNKYMSATYLPCVAKEQNWSKEETLNNLFVKAGMNGDVFDWKNLNMKVIRYQGSKAECTYDEYMKIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7PD91</accession>
    <name>M7PD91_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_03260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875327.1">
        <property type="nucleotide sequence ID" value="XM_007877136.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PD91"/>
    <dbReference type="STRING" id="1069680.M7PD91"/>
    <dbReference type="GeneID" id="19896947"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03260"/>
    <dbReference type="eggNOG" id="KOG1061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006320_4_0_1"/>
    <dbReference type="OMA" id="NPPEVQW"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="16"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="677" mass="77530" checksum="2DFA9C734219EDAB" modified="2013-05-29" version="1">MIERSIRNIQGLWKGETYELKTGLVSQYAHERKEAIQRTIAAMTLGKDMSMLFPDVLKNIATSDLAQKKLVYLYLMNYAKSHPDLCILAVNTFVQDSEDPNPLVRALAIRTMGCIRVDKIVDYLFEPLRKTLRDSSPYVRKTAAICVAKLFDINPEMAIENGFLEILQELINDTSPMIVSNAIAALSEIVELLPEIQISIITSSTLPRILTILNESSEWERVVLLGILANYTAENMKEAESICEHVIPQFQHANVSVVMAAIRVVMRNFPIISKDMAKQIMRKLSPSLVTLVSSVPEVQYVALRNINLILQEYPNILDKDIKVFFCKYNDLEYVKLEKLNVMIKLANKRNIDQILSELKEYASEADIDFVRHTIKIIGQCAIKIEEGADQCINLLLDLVNTKINYVVQEVVVVIKDIFRKYPNKYNGIIPAICENMSLFDEPNAKSSFIWIIGEYSEKISDSRDILLSYINFFKDEDIQTQLQLLTATIKLFLKNPKNNQEIIQKVFEIIESGCDIPDMRDRAYIYWRLLSKDIEIAKEIVLPSKVPVFCKNIPPKLLRELICEFSTLASVFYKLIPTHVKLDKDGKDLMKQKAIEEYMQINNRTRANFKRNTENLLDIDFDAENTINPADESYDIMSGPYIPNSMKPSNVDDLLNAFGSNQEKQTDLLNMDMLNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7PDM4</accession>
    <name>M7PDM4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SART-1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_03046</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNU66/SART1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875101.1">
        <property type="nucleotide sequence ID" value="XM_007876910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PDM4"/>
    <dbReference type="STRING" id="1069680.M7PDM4"/>
    <dbReference type="GeneID" id="19896733"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03046"/>
    <dbReference type="eggNOG" id="KOG2217">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009379_2_0_1"/>
    <dbReference type="OMA" id="KRRDYTG"/>
    <dbReference type="OrthoDB" id="5583at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000481">
        <property type="term" value="P:maturation of 5S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045347">
        <property type="entry name" value="HIND"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005011">
        <property type="entry name" value="SNU66/SART1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152">
        <property type="entry name" value="SQUAMOUS CELL CARCINOMA ANTIGEN RECOGNISED BY CYTOTOXIC T LYMPHOCYTES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152:SF5">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19252">
        <property type="entry name" value="HIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03343">
        <property type="entry name" value="SART-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="415"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="604" mass="70087" checksum="79FF44CA67F813C5" modified="2013-05-29" version="1">MTESSVKDSFTAESMTVEETNALRRSLGLAPLSETVEPVEDPAVTNFKEFRAAKIKEEETRLIQERIRMARETRETQRRFTGKGLGEASDEGDLDLRSWVMNHRKRNFSHVTDKENVVSEKLEKMQKKDKKEEYTSDQLEGIKVSHDFTDINEGEAIVLTLKDSTILENEDQGDELENIGLVEKEKLEKNLENKKKFVYTGYDDDEFSEEKSKTILSQYDEKVKKGFVIGNVSQEPQEEIWKKGHQEIFSLNHTSVENISSDYQDISQIVIKKIKKKKINRMRKVDHDLIADSVDMKHIMQNSDNMVSHKDLNFDNVSFVDDDDLQACLARQREASRRKKTSHPESVARLVKEQMFEELKENGDKNDGGLVIDETTEFVRGIQAIAPKEKQKVLENIEYIQNLETPEIVEENSQDETKESPYDESDKFTKNISTTGIEDEADISSGVGVVFNLLKQKGIVDKQTDEALSVQRAQHEHSLFLAEQKKLRRKLEEEARYRKEADRCSGKLDRMTPRERELYLQAENQRHAMIEARELQKLFAKWTPVIQLKYNDEFGREIKDKEAYKFLSHQFHGKGSGKAKVDERLRKLAEEKKKEQQSIFSYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7PEL6</accession>
    <name>M7PEL6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small COPII coat GTPase SAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Small COPII coat GTPase sar1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PNEG_02691</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 21">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874715.1">
        <property type="nucleotide sequence ID" value="XM_007876524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PEL6"/>
    <dbReference type="STRING" id="1069680.M7PEL6"/>
    <dbReference type="GeneID" id="19896382"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02691"/>
    <dbReference type="eggNOG" id="KOG0077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_6_0_1"/>
    <dbReference type="OMA" id="GLWNKHG"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007006">
        <property type="term" value="P:mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902953">
        <property type="term" value="P:positive regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070863">
        <property type="term" value="P:positive regulation of protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00879">
        <property type="entry name" value="Sar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000161">
        <property type="entry name" value="Small COPII coat GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45684">
        <property type="entry name" value="RE74312P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51422">
        <property type="entry name" value="SAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10 21" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 21" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="13 21" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 19" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 21" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU003926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EMR08909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="189" mass="21290" checksum="AF400B43BC09A556" modified="2013-05-29" version="1">MFIINWFYDILASLGLMNKHAKLLFLGLDNAGKTTLLHMLKNDRLATFQPTLHPTSEELAIGNCLFTTFDLGGHQQARRLWRDYFPEVDGIVFLVDSSDVERFLESKAELDALLSIEELSKVPFLVLGNKIDAPGAVSEEELRVTLGLFQTTGKGKVSAENIRPIEVFMCSVVMRQGYGDGFRWLSQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7PEM1</accession>
    <name>M7PEM1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02696</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PLPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874720.1">
        <property type="nucleotide sequence ID" value="XM_007876529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PEM1"/>
    <dbReference type="STRING" id="1069680.M7PEM1"/>
    <dbReference type="GeneID" id="19896387"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02696"/>
    <dbReference type="eggNOG" id="KOG2214">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009031_2_2_1"/>
    <dbReference type="OMA" id="CSWFTRG"/>
    <dbReference type="OrthoDB" id="15478at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990748">
        <property type="term" value="P:cellular detoxification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006642">
        <property type="term" value="P:triglyceride mobilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07232">
        <property type="entry name" value="Pat_PLPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF66">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE PTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="7">
        <location>
            <begin position="270"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="5">
        <location>
            <begin position="301"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="626" mass="72815" checksum="D9C6D5019213928A" modified="2013-05-29" version="1">MVKTDKEKGKSKVISSLNSLPDFYIDFCNIDDIKEYEKCIFSSETLEDQEEIIDLIDEKCPVHEYVQKHKKISHNKFRKGTDEKREGIMHYLLRWPIVIFIFGYLFILSILYIITRFYIELYERLYIWRGQRQRLRKKLYKADSYTEWKQAASELDRFLGNDKWMEDPQFDYYDYQLIDKVSKYLKTYRKNEDLEALKSALETCIKPNFGGIENPLLYSQTYFGTKYLAEGYITEVEKCLIYMINTPKIPIEDKRSFFEYLTKNYGHSALCLSGGATFAFYHLGIIKALLDTKLLPNIITGTSGGALIASLVCTRTDEELMALLVPELSHKITACSDKTLTWLKRWWKTGARFDAVDSAIRCTWFTRGSTTFMEAYKRTGRILNISVVPNNIHSPPKLLNYLTAPNTVIWSALIASAAVPGILNPVPLMSKNPDGQLAPYNFGNKWKDGSLRTDIPIHSLHIYFDVTYSIVSQVNPHINTWFFSPRGSVGNPVSHKRGKGWKGGFLGSAIEQYLKHDMFKWLRLLRNLELMPRPFGQDWTHIFLQKFEGNITILPKTIVSDFWYILTDPDETRLNRMILYGQKATFPKLLFISHRMRIEKLIERGCLYTQSPYTEKPIQKIHSAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7PF66</accession>
    <name>M7PF66_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cdc23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02453</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874461.1">
        <property type="nucleotide sequence ID" value="XM_007876270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PF66"/>
    <dbReference type="STRING" id="1069680.M7PF66"/>
    <dbReference type="GeneID" id="19896146"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02453"/>
    <dbReference type="eggNOG" id="KOG1155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018320_2_1_1"/>
    <dbReference type="OMA" id="ERCLYHS"/>
    <dbReference type="OrthoDB" id="10262026at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007192">
        <property type="entry name" value="APC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04049">
        <property type="entry name" value="ANAPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cdc23" evidence="8">
        <location>
            <begin position="10"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="327"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="361"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="395"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="555" mass="64720" checksum="C0A542AF61442997" modified="2013-05-29" version="1">MNEITSKHTIHLQLKDAISQCSERGLYLSARWAAELLNGMEPLTMNDISEYSKYKSNYLKKKEEKENLFELGCQEEQESNQYSLAKCYFDCKEYDRCSYFLKTCHSPKSIFLRLYSKFLAGEKRGDEDSESILGPLDASNVKNREITSICQELEKIIEIEKDAFLLYLLGFLQRRQKQDSLSIKTLIQSLNLYPYNWGTWQELSMCLAGINMLNSITSALPECFMKKLFLIYAILELHQSGETLYHQIMELETLFPNSLFLKTQRALIPYNGRDFEEAEKQFEEIAKLDPHRLDDMDIYSNILFVMSKRSKLGFLAQIASATDKFRPETCCIIGNYYSLLSEHEKAVIYFRRALKLNRNWLSAWTLMGHEYVEMKNTHAAIEAYRRAVDVNRKDYRAWYGLGQTYEVLEMHYYALYYYQRAAALKPYDQRMWQALGNCYEKLDRPGEAIKSYKRALLGSTGDPVILLKLGGIFERIGDTDTAAMYYKQCITAEEDDVITLESSKAHMWLAKWEMSRGNLRKAEKYATEIMNGSFDLEEAKALVRDLRSRMDQNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7PFN1</accession>
    <name>M7PFN1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02588</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874603.1">
        <property type="nucleotide sequence ID" value="XM_007876412.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PFN1"/>
    <dbReference type="STRING" id="1069680.M7PFN1"/>
    <dbReference type="GeneID" id="19896280"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02588"/>
    <dbReference type="eggNOG" id="KOG0998">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_272034_0_0_1"/>
    <dbReference type="OMA" id="PRSTDHW"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF170">
        <property type="entry name" value="DYNAMIN ASSOCIATED PROTEIN 160, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="5">
        <location>
            <begin position="21"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="5">
        <location>
            <begin position="134"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="5">
        <location>
            <begin position="290"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="323"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="955"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="522"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="955"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1189" mass="135237" checksum="B17CD32207D53AFB" modified="2013-05-29" version="1">MNSKIQKTSEHDILVNLTPEESEAYEKLFCEADPDNIGVLLGENSINFFEKTGLSPQILGEIWKIADDENMGFLTRKRFNIALRLVGHAQEGRRPSIDLINLKCPLPKFNTKKPINWNIPSQPPEKIPLITTEERNRYHNMFKNLKLTNGFIKGSQAKSIFLRTHLSNEILGQIWNLVDIHHRGALNITEFTVAMHLIHSFINGSLKKIPSILPPWVFNMAIGKTYSHGSSHKVISEHSVTKNTSNLNEKDFSNNLSRKYYKHQHVHSKPNLFFEIDTIPPNDWNIKPQERFQYSNLFKSIDKANENYLTGDEAVSFFLSSKLPEKTLAHIWDLADLDKSGKLNKEEFIIAIHLIRQKLVGVDLPASLPQELMPPFFQKNLPQENTYFLSPSNQEPSSSITTESFDINNSFSPQVQTTSPSLPSSIFSIKQTTTDPYVEASAIIPSSDSVFSPSCSHLETPSIHSSQRAPFISTSAFKQSIVSSVTPDSKASLQKPSTTVVDLLSDTNIENLEKKDNDTSEMENTSNKISSLSKQIQELKQTVTLTESELKASNDENCEIEERLSQIYILYKKEVKTVQKIQEDLTESRATTQKLKQKYSILKTRLYTLQNQKQEQLENLKHSTDENIELQHKIELMNNQLSCLKEELENIGKDSLDQKNMIMMSKKQLSIFEDNYTQLKANIDKDIVIHNVNENNDSDSVLSTSNQSSNPFHQISDSNEIKQISPLFIPVRNKINTKGQSNIQDNSIKDLSSNINLQILKRRDSLSESLDSSVVVQAPESTPGKLSRISSYPGTPIPWIMNKSNSPKILNELSSNFDSDIFLKDSSIEKFEFYKENPYYDLEVTNVSSNSKKNSDESCNENEFKKGTFNVNNLDTELLYPSNNKEDISLDSSSRLDDILYKECSIRYSDIQNTTLPEENITGKLPGTFPVDSDSRIVNQEIYYTFNDKEKSIKDDKTNKKTENAHFDPFSSKNSNDIVPKKNKADFDEAFSNFIAESDDFSKNDNFASKFPPIEDFHNLSESNDINNYNNDLIAHNKNKDPVINLSTFNADYNVSYNTETSTTDGKNIMNSNTVQLLINNFKETQSKESLSSLHKFDSNNIEISDVTLQLDNIPEKYEDKRFHDLIATKEVNSFKSDLSTQDIKFNTFFTQPFSEEPKHDWVAINCTTDSPLLNGQDISINPDPTSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M7PG14</accession>
    <name>M7PG14_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_02344</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874348.1">
        <property type="nucleotide sequence ID" value="XM_007876157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PG14"/>
    <dbReference type="STRING" id="1069680.M7PG14"/>
    <dbReference type="GeneID" id="19896037"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02344"/>
    <dbReference type="eggNOG" id="KOG3467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109117_2_3_1"/>
    <dbReference type="OMA" id="QKEHING"/>
    <dbReference type="OrthoDB" id="3919494at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000007">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="12">
        <location>
            <begin position="37"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR09399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="103" mass="11366" checksum="014CA2AA4F24AD30" modified="2013-05-29" version="1">MSGRGKGGKGLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGVKRISALIYEETRGVLKVFLESVIRDAVTYTEHAKRKTVTSLDVVYALKRQGRTIYGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7PG51</accession>
    <name>M7PG51_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02381</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Vacuole membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874387.1">
        <property type="nucleotide sequence ID" value="XM_007876196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PG51"/>
    <dbReference type="STRING" id="1069680.M7PG51"/>
    <dbReference type="GeneID" id="19896074"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02381"/>
    <dbReference type="eggNOG" id="ENOG502QR9I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017518_1_0_1"/>
    <dbReference type="OMA" id="QQQWEMY"/>
    <dbReference type="OrthoDB" id="192733at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032974">
        <property type="term" value="P:amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17483">
        <property type="entry name" value="MFS_Atg22_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044738">
        <property type="entry name" value="Atg22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="4 10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="344"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="478"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="533" mass="60485" checksum="91343C754FAF0115" modified="2013-05-29" version="1">MTFIADQQDSPILEEHIGFTSKKDILGWYSCGFSNEVFSSVSITTFIPVLLEQLVRSSGVLLSDKSTPCLFHDSFFAFNLFRVDKKSNLCVIYIHGIGWIDSYSFSLYVYSIASFFQVIVIISISSLADYGKNRKMLFLVFSIIGGISSISFIFINRRYLFASFLFVLSSMCFSASTVLLNAFLPGLCRNHPSVLKERKILDSLWQSLSDDGFGKENVSKGNHIYRDYLKTYDLHISSLISDLSSTFSSRGIAIGYLGAIIFQIVSIMIIFVFGSGIKSFQIIICATGLWWLVFTIPVALWLRSPLLPSLSKGILGNYPVIGYILYSWKSLIQTFLDIRKYKKIMLFLIAWFFISDAYSSISSTTVLFVKSTLHISPLGFIIITFLSTLFGVMGAFLWPYIARSLNFSLSQVLVFILFLSLFIPVYGILGLFPISLGLKRPIEIYILSMFFGFLYGGIQGYSRALFGKLCPENYETRFYALYSITEKSSSFFGPALVGYIFHFTHNMRYSFFFLLMVMTISIFILFRSKISDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7PH75</accession>
    <name>M7PH75_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873950.1">
        <property type="nucleotide sequence ID" value="XM_007875759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PH75"/>
    <dbReference type="STRING" id="1069680.M7PH75"/>
    <dbReference type="GeneID" id="19895666"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01972"/>
    <dbReference type="eggNOG" id="ENOG502QQB6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_435529_0_0_1"/>
    <dbReference type="OrthoDB" id="5401119at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060962">
        <property type="term" value="P:regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018837">
        <property type="entry name" value="TF_CRF1/IFH1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10380">
        <property type="entry name" value="CRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="628" mass="71803" checksum="A70FC058F2F8B472" modified="2013-05-29" version="1">MKKKKQRSSSDKEVFNVRNRLGSTLPPGRHHEEEKENKEITSFALRDMFLSLENEEDEGWINRGKEVGGVSKESYLIKYGNNVERIDMNEICSTYNGKRIQEFSIPKSLERQKQPRLQSYDKQILSIPNHKNNIKESHLILNKLSQGHYSNGSSNACCDISDEVVVCNNFSFNKKVWKKGLLSGAKGHNSVETNGSNLDSEERENIFRSKISKNNFFNELSDLDYYDDDGIFYFDDSSSSTSSFKESDERNYRNTLSTDGSEVEKPCSILVKEDKNSQVYHDGSRTQISYSNDEDLFLSGDFQDESSYIPFFRTQTYEEYNSSDDIWSFYTSSLFSETNDTNDIKDINSIPDKPFFENNFDISNEKGYTTDEDQNFIVKKKNQEKKVEVSDNNFEKEHSCFTETNDHTMALHNSKTSKSSKKENLNIETVSTNSSSNSGTTTSNALNKPPILGTWTRDLKRPIGIIDGISTNVINPVTSSCTILSPTSNLSPLSIPSLDDILDTSAFVQLSSSNSSSSITKNYLSDFYRWDKIPIGTFRRHQQRFMNTRDELIKGEWYVLTNKSRKQRSNVPILGTTVRHKKKKLKKKRNKNKLKANIELFEEDKEVEMEHCGLGLGPQLSPLFNGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M7PIE1</accession>
    <name>M7PIE1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01496</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873436.1">
        <property type="nucleotide sequence ID" value="XM_007875245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PIE1"/>
    <dbReference type="STRING" id="1069680.M7PIE1"/>
    <dbReference type="GeneID" id="19895192"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01496"/>
    <dbReference type="eggNOG" id="KOG0446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008964_5_2_1"/>
    <dbReference type="OMA" id="IQRRKEC"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000473">
        <property type="entry name" value="Vacuolar sorting-associated 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF220">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="8">
        <location>
            <begin position="36"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="7">
        <location>
            <begin position="610"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="540"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="696" mass="77936" checksum="9AD8DA2F703718CA" modified="2013-05-29" version="1">MSGETNALRGGAMDPQLIKTINRLQDAFSTVGVQNPVDLPQITVIGSQSSGKSSVLENVVGRDFLPRGTGIVTRRPLILQLIHRLSTTNKENQSEDEKATEGEGYVNSDEWGEFLHLPGRKFFDFNEIREEIIRETESKTGAKGISPIPINLRIYSPNVLTLTLVDLPGLTKVPVGDQPKDIEKQIREMILKYINKPNAIILAVTAANTDLANSDGLKLAREVDPEGTRSIGVLTKIDLMDKGTDVVDILAGRVIPLRLGYVPVINRGQRDIDQKKAISAALEYEREYFENHPSYRSKVQYCGTPFLARKLNIILMHHIRNTLPEIKAKISSALTKYQTELAQLGDSLLGNSANIVLNIITEFCNEYRTILEGNSQDLSSLELSGGARISFVFHELYANGVKAIDPFDQIKDTDIRTILYNSSGSSPALFVGTAAFEVIVKQQIRRLEEPSIKCINLIYDELVRILSQLLGKQLFKRYPLLRERFYQVVINFFKKAMQPTHKLVQDLISMESCYINTAHPDFLNGHRAMAIINDKINQSKPVQLDPKTGKPLPVTKENSVSQSLEPGTDNGGFFGSFFASKNKKKMAAMEAPPPVLKASGTLSERETIETEVIKLLINSYFNIVRRTMIDMVPKAIMYNLVIYSKEGMQKELLENLYKADILDDILKESEYTVQRRKECLRMVESLTQASEIVASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJ81</accession>
    <name>M7PJ81_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01225</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873144.1">
        <property type="nucleotide sequence ID" value="XM_007874953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJ81"/>
    <dbReference type="STRING" id="1069680.M7PJ81"/>
    <dbReference type="GeneID" id="19894922"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01225"/>
    <dbReference type="eggNOG" id="KOG1632">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_641113_0_0_1"/>
    <dbReference type="OMA" id="SEELFCI"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16039">
        <property type="entry name" value="PHD_SPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037869">
        <property type="entry name" value="Spp1/CFP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174:SF1">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="6">
        <location>
            <begin position="142"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="428" mass="50365" checksum="1A264D921A9FFC34" modified="2013-05-29" version="1">MHLISKENNQNKHDIKMDIIDVKVDDHSFKQEEDVIIVLDYEKNRSEASHLIYTNNILDYKKRVETQAEYIDASASRESSIHKKDIKKEKTRKRKINGLNIEGSNISELENDCKSDVFLNNMIKRPQINNFNNIKNENIELYCICQKPDTGCWMIACDGCDNWYHGECVKILEADEELLDKYFCDFCTKKGKGCTMWKRKCRLSSCRKPALVSSFPPSKYCSTEHGVEYFKERLCCSLLEKSEIAALARSVDSVEAFRCLGDTFPFIDDSIVNSESLSLLRLINFKREKIYERLKQIEIRTIYINFAKDRAKKINEEIRADGSKKEICALDYRLSWDDDEWNAWIVSDDGKKIFNDGKLEGYDMICITEKRKCFKHNNWVMIKIEEMELEDIICRETLKKLRRQEQKIYKRERKLKVLDKENKCIATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7PLX2</accession>
    <name>M7PLX2_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872365.1">
        <property type="nucleotide sequence ID" value="XM_007874174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PLX2"/>
    <dbReference type="STRING" id="1069680.M7PLX2"/>
    <dbReference type="GeneID" id="19894178"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00480"/>
    <dbReference type="eggNOG" id="KOG3322">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007205_0_0_1"/>
    <dbReference type="OMA" id="WNAKRSH"/>
    <dbReference type="OrthoDB" id="442863at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039182">
        <property type="entry name" value="Pop1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055079">
        <property type="entry name" value="POP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009723">
        <property type="entry name" value="Pop1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012590">
        <property type="entry name" value="POPLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731:SF3">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22770">
        <property type="entry name" value="POP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06978">
        <property type="entry name" value="POP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08170">
        <property type="entry name" value="POPLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pop1 N-terminal" evidence="4">
        <location>
            <begin position="53"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="POPLD" evidence="5">
        <location>
            <begin position="466"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="POP1 C-terminal" evidence="6">
        <location>
            <begin position="663"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="725" mass="84395" checksum="9E6DBF6BCEE1CBDA" modified="2013-05-29" version="1">MNKEDILNKNRKENSEDVVSVKKRVKNPDLRMIMVESDSPAIREGCIDVKSLVNSRKFEIRSLFEAMRCSRQLSAQRAFQSLPRFLRRRSASHDFKRVPKYLRIRAKNEMKNKNTLKKKGIKGKKRMRLLTVHKLKKFGVRNVSVSEESKDELDESKDDFLKVKKVKGKFYKRQKDKTWLPTHLWHVKRAKMLTKWSYSIAKTPTEKSYRPTHKFANTSGAVAFDTSYFCTICLWGEIENLKRVLQQFTASDSGVTRGRYTRGTRFCQTMIYQKDSNFLSLICPAIFLWQKIGDSQCVMIRFHPVAFKQVYIQMKEASYLENVKVEDCRFDIGGIDIHGPASTLALQCLFDVKMSDTTSQIWSEIKYVSQIKSLPIGIVIPLDIRDPRLTFPPRIINEDKGFSSVLIKSWKDDLIPSSRLFDTEARMRCQRNQLSQQRINHLRSESSESSVPYDIPILLFRCEICWTVLAPWNWITHLWHSLMHIPRVRFGGMQEKHQLEFEEGIPYFPSDYHGTLAGDENEKIEAEYREFEWKKRPPAKRISWSSVVTKDGKGELGNPFICDWSYLFLNFCKNNSDNPENEHKLLHMDLHLISGVDVKSKFDTSLYKSMKLVFIVKITMLRRGCPDSCARVYSIPVEEKEIWNRFLKEIVPYGDENYPLCPSSDNLLGFVTSGNFNLKRGKMTAIGCFALHKISKTLLDDKEKYCIIRNVGSSTVNIAKWEFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7PM36</accession>
    <name>M7PM36_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome c oxidase assembly protein CtaG/Cox11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PNEG_00544</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Associates with the mitochondrial ribosome (mitoribosome). Only transiently interacts with the mitoribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the COX11/CtaG family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">In the N-terminal section; belongs to the methyltransferase superfamily. Rsm22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872435.1">
        <property type="nucleotide sequence ID" value="XM_007874244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PM36"/>
    <dbReference type="STRING" id="1069680.M7PM36"/>
    <dbReference type="GeneID" id="19894242"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00544"/>
    <dbReference type="eggNOG" id="KOG2540">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045000_1_0_1"/>
    <dbReference type="OMA" id="NKLECFC"/>
    <dbReference type="OrthoDB" id="1704689at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005761">
        <property type="term" value="C:mitochondrial ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.370.10:FF:000001">
        <property type="entry name" value="COX11 cytochrome c oxidase assembly homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.370.10">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00155">
        <property type="entry name" value="CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023471">
        <property type="entry name" value="CtaG/Cox11_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007533">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_CtaG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003465">
        <property type="entry name" value="PRK05089.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04442">
        <property type="entry name" value="CtaG_Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110111">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00065979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMR11534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="26434" checksum="33C13733482F482F" modified="2013-05-29" version="1">MIQKNIFFQWRKYISQRKHFEFPNVFNFFRSLHTDPRIQSRIRNQSVLLYTSSVLLGIFGISYASVPLYRMICQKMGWAGTPIIESSKFTPDRMIPIHDAERIRITFNADVSDSLEWNFVPLQKEIYVLPGETALAFYTAHNRSDKDIIGISTYSVAPAQAAPYFSKIACFCYEEQKLNAGESVDMPVFFFIDPDFVKDPLVRNIRTITLSYTFFKASHVKVNNLIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7PMJ8</accession>
    <name>M7PMJ8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">P/Homo B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_00129</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871989.1">
        <property type="nucleotide sequence ID" value="XM_007873798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PMJ8"/>
    <dbReference type="STRING" id="1069680.M7PMJ8"/>
    <dbReference type="GeneID" id="19893827"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00129"/>
    <dbReference type="eggNOG" id="KOG3525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002976_2_1_1"/>
    <dbReference type="OMA" id="NEDNGAY"/>
    <dbReference type="OrthoDB" id="300641at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000026">
        <property type="entry name" value="proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004083038" description="P/Homo B domain-containing protein" evidence="11">
        <location>
            <begin position="22"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="925"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="12">
        <location>
            <begin position="491"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="638"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="960"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="660"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="676"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="689"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="702"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="713"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="726"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="813"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="826"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="872"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="960"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="985"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7 8">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7 8">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7 8">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR11694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1011" mass="112021" checksum="FBE472C8F65864E8" modified="2013-05-29" version="1">MVYKIFLAFFLCWIFLIRVKSEEKPKDFENKDYYHFHFSKDVDLDAFSQELGFEYEEALEHLDGHYLFSIDKGVSDDKIEEKIKDYFGLEGNIIDGFNSDKLFYYEKQKLLRREKRNVIRDPMYLDTSQNSGDTGNVNSGEKDQQIKLLEEKFEEIKKKLNISDKYFGKQWYLFNKKNPGVDINVTGLWLEGITGKGVTVGVTDDGLYYKNEDLIQNYCAEGSYDFNTQTSDPSPKRSDDTHGTRCAGEIVAAKNTFCGVGVAYDAKVSGIRFLASVLSSWLEGKALSYRYDINDIYSCSWGPRDDGKTIEGVPYSAYNSIINGINLGRKGLGSIYVFGSGNGGYYDNCNYDGYVVSPYTITIGSIDVRGIRHYFSEQCSSVLASTYSGSIVTNARIYTTDVGEKGCSTVHSGSSASTPIAAGVIALVLSVRPNLTWHDIQGLIVESAVPFSLDYPGWEKLPSGRYYHYYFGYGKLDAYRMVEAARNFKHLNPQARFSVPMIIVNKKFSENNGHITDKFNLIKAYPDYYNFGKLERVSVTLYFQHAKRGSLEINITSPSGVTSMLTHRRLHDKNYGYVHWTFSTVKHWGEPIVGEWTIDIEDQKIPNLDGEFYNWQLHFFGESADLTKTQSIVYPFITRSPSPIPGEPTVYLPTPSATISPSVSPQPTSESTSEPTPQPTPQPTPQPTSEPTSEPTSEPTSKPTPQPTPQPTSEPTSEPTSEPTSEPTPQPAPPQPAPPQPAPQPAPQPAPQPAPPQPAPPQPVPPQPVPPQPMPSRPAPPKPTPQPTSEPAPQPTSESTSEPTPRPPPQPTSEPTSEPTSEPTSEPSPQPTPQPVPQPAPQPAPPKPAPKPTPPKPAPKPTPPKPAPKPAPSKSSSKPTSTSSSFISSSTKTKTTTQKASPTSASGRSSSTQSASHTSFFKRNLLLISILIASIILLIFGFLFLFIRFFKKRDSYTNGHPVTETLNYESDPNMSQETEKATMLKRNQQVTSSDLSDTEDPNMYERRILRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7PMW1</accession>
    <name>M7PMW1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pinin/SDK/MemA protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_00211</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pinin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872079.1">
        <property type="nucleotide sequence ID" value="XM_007873888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PMW1"/>
    <dbReference type="STRING" id="1069680.M7PMW1"/>
    <dbReference type="GeneID" id="19893909"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00211"/>
    <dbReference type="eggNOG" id="KOG3756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1326868_0_0_1"/>
    <dbReference type="OMA" id="NEDSHME"/>
    <dbReference type="OrthoDB" id="330772at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039853">
        <property type="entry name" value="Pinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006786">
        <property type="entry name" value="Pinin_SDK_MemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707:SF0">
        <property type="entry name" value="PININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707">
        <property type="entry name" value="PINN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04696">
        <property type="entry name" value="Pinin_SDK_memA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Pinin/SDK/MemA protein" evidence="10">
        <location>
            <begin position="38"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="64"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="154"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR11784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="207" mass="24676" checksum="8D3E988B408E6904" modified="2013-05-29" version="1">MDPEVVVESMVFLPEQERLRDQEESSQRRDRRQRMGLDEQKRGQRFLGTLMGTLGKFQKESVFLQEKNAKRAEIEARLAECMRKEKEALEERARIEQDEKQRAAERLRRASLREFEKLSLETYYKNEMASARALKTTTLPVLFYQPWKLSSKEEERAKIRIEELERKYQQELKELEERLSREDNLYLKDVDTSLSAHETCQINVDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZX08</accession>
    <name>A0A0W4ZX08_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">orotate phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_04292</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="5"/>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="KTW32905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613377.1">
        <property type="nucleotide sequence ID" value="XM_019757811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZX08"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZX08"/>
    <dbReference type="GeneID" id="30671580"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04292"/>
    <dbReference type="OMA" id="SPFFMNA"/>
    <dbReference type="OrthoDB" id="5553476at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046132">
        <property type="term" value="P:pyrimidine ribonucleoside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000008">
        <property type="entry name" value="Orotate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683:SF1">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="9">
        <location>
            <begin position="52"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KTW32905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="219" mass="24642" checksum="BC4BE95F9010B2B4" modified="2016-03-16" version="1">MGYKDDVLFLSKKSGALKFGTFFLKSGRKSPYFFNSSFMNSSVLLKSLAIAFSHVILDLNIEFDIIFGLAYKGIPLGAITTLKLCELDKTKENIEFVYHRKEKKDHGEGGNIVGTSMKGKKVLILDDVITAGTAIREAISIVEKEGGKLVGIVEILDRQEKGNDGEVSVVEMMRQEYQIPVKAIITFKDIIDYSKKELNEEKLKLIQEYRDKYVIESAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M7NIT1</accession>
    <name>M7NIT1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_02991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875040.1">
        <property type="nucleotide sequence ID" value="XM_007876849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NIT1"/>
    <dbReference type="GeneID" id="19896678"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02991"/>
    <dbReference type="HOGENOM" id="CLU_1787632_0_0_1"/>
    <dbReference type="OrthoDB" id="10587784at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="145" mass="16159" checksum="2F78E283ECB5B22E" modified="2013-05-29" version="1">MRKNLVLFISRGKVIQQNSRLSNTTNSIVPHTVISLNSTNTLTNGRRNSTRNSIEKFTFVQASLIKEIIKEGKISKKCISFLMKDTWMTNTSLHTNTITNISTITSTVIKKIQIGEEMALGGGMKMRILGMIKIMLLGVIVMGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJM7</accession>
    <name>M7NJM7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">THUMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02972</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875018.1">
        <property type="nucleotide sequence ID" value="XM_007876827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJM7"/>
    <dbReference type="STRING" id="1069680.M7NJM7"/>
    <dbReference type="GeneID" id="19896659"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02972"/>
    <dbReference type="eggNOG" id="KOG3943">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039352_2_3_1"/>
    <dbReference type="OMA" id="MNEKACV"/>
    <dbReference type="OrthoDB" id="367221at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180014">
        <property type="term" value="F:protein-tRNA adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11717">
        <property type="entry name" value="THUMP_THUMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2300.10:FF:000001">
        <property type="entry name" value="THUMP domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2300.10">
        <property type="entry name" value="THUMP superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452">
        <property type="entry name" value="THUMP DOMAIN CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452:SF10">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="2">
        <location>
            <begin position="115"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="227" mass="26102" checksum="ECD8047C7BC54F96" modified="2013-05-29" version="1">MLLPNWSGVFITCVRKHEKQAEREVLDLFYQYLDEQVPELFISSSIKSDDVSLSSDKSFKLSSGSFEDQISQELAILKKKERWLQPINIKTACVIFIRTRWPLDPVQIVRYICEKISSNGIKGIRWSKRMTPVTLTASATLLDLQNLAQKFAIRPNLRNHTKLTREQIIRTIAPLIGAPHKVDLKNYDVLIMVEVFKNICGISVVRDFEKLKKLNIASIMESVVKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJN7</accession>
    <name>M7NJN7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875033.1">
        <property type="nucleotide sequence ID" value="XM_007876842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJN7"/>
    <dbReference type="STRING" id="1069680.M7NJN7"/>
    <dbReference type="GeneID" id="19896672"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02985"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_394363_0_0_1"/>
    <dbReference type="OrthoDB" id="10044938at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12342">
        <property type="entry name" value="RRM_Nab3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034167">
        <property type="entry name" value="Nab3_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052600">
        <property type="entry name" value="Nuc_rcpt_coact/corep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23295:SF6">
        <property type="entry name" value="NEOSIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23295">
        <property type="entry name" value="NUCLEAR RECEPTOR COACTIVATOR 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="284"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="351"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="699" mass="79514" checksum="74BF7025AD4D1E41" modified="2013-05-29" version="1">MKCKEPILSNSDYKNMIQNDNKNKGNIKEDEGDNFTPIRESENGFLETSIELSNTHLKELLETLPRPYSEKNDHAELRLTFGLEKKIENVLSMNKEIPDKKCTIIETPNKQIPELAVQEYVPSSENDKIDYSFANMNQDLSYKTKIQPLDNDQVNPKRHSPETIQQNCQLLSDTLNPIPSSLDLQKLLASLSPVSKVDPQSVTFQATANNSLSPDLLKALNSVSSITDTNIIQSSLIQHPNYKNAISNHEAPYTPQEDALFQKFLIDEKQIMSNTAPHEFPPGSRMFIGNLPTEKVTKKDVFRIFYPYGRLGQIALKQAYGFVQFFSSEECQNAINGEQGTMIRGRKMHLEVSKPQKHRIPPSNDKKNYRARSRSPDIRDRSPVRERSRNHGRGNHGYSILYDRDNKKDRYSSRDEFGKRPSSQSRYHRDRGIDYGKDYRSTSPDRFRDYSHSHQQMDNFPLPLRYGNNVPECQIIITDDTDRSFIYFVEKAFKEKGFRIDTLFLSPRLPLPSVVQQMIIEGIMAIIFLNRQLQSQSKISMQIFDRKADSSDVKFDEYANIDVHVAVVLALRKKQSILQLTNTYGISNYNNTSFQSQNTPSFGIANSDLANLIGSLDPTTLQKVIGALTQSSQQLAPQIQHMPYTASLQIPYQGSPTNQNYQINPGIVPLITSTIPSQGQQPAQQVQDILGQLAKLQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJS1</accession>
    <name>M7NJS1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02648</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874669.1">
        <property type="nucleotide sequence ID" value="XM_007876478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJS1"/>
    <dbReference type="STRING" id="1069680.M7NJS1"/>
    <dbReference type="GeneID" id="19896339"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02648"/>
    <dbReference type="eggNOG" id="KOG3079">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032354_0_2_1"/>
    <dbReference type="OMA" id="GTQCDRM"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="250" mass="29309" checksum="810C37289C277EBD" modified="2013-05-29" version="1">MMIDRIICRIWRTHSRNTRKEVEKVKEKDDYWIFWMKSFFNDIKKEPSRNISSKPWFDPKEVTVVFVLGRPGSGKGTQCAQLVRDYDFVHLSAGDLLRQEQARPGSGYANMIQQSMQNGQIVPMHVTISLLKDEMIQSVTRGKKRFLIDGFPRKIDQMLAFEKNVCPCKFTLDFHCSESILIERLLARGRRDDNIDTIRKRFKTHQELTVPVLEYMEKQGKLIRVACENSIESTYQETLDQIEPFLKLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7NKP2</accession>
    <name>M7NKP2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02549</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874562.1">
        <property type="nucleotide sequence ID" value="XM_007876371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NKP2"/>
    <dbReference type="STRING" id="1069680.M7NKP2"/>
    <dbReference type="GeneID" id="19896241"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02549"/>
    <dbReference type="eggNOG" id="KOG0874">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043293_1_1_1"/>
    <dbReference type="OMA" id="FETKPCK"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102772">
        <property type="term" value="F:sphingolipid C4-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042284">
        <property type="term" value="F:sphingolipid delta-4 desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="99"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="255" mass="30380" checksum="FDF62FBF0E68316C" modified="2013-05-29" version="1">MNNVLMLILPIVFYWVFSFFFFILSFLKNPKIEKYKIHQVSNGNRVSCFKVIRDVLFQQFLQIIIGYIFLSKTLEPSSCIYFDNYIKGSRRVFLFFIQFFLALVILDTWQYFFHRLMHYNSTLYRYIHSKHHELYVPYAFGALYNHPVEGLLMDTIGAGLAFQLSGLGAIGGCIFFCFSTVKTVDDHCGYVFPYDPLQRFFYNNSKYHDLHHQPYGMKFNFSQPFFTFWDHYFNTYKNVETSKCISSLTPEKKHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLD5</accession>
    <name>M7NLD5_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874046.1">
        <property type="nucleotide sequence ID" value="XM_007875855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLD5"/>
    <dbReference type="STRING" id="1069680.M7NLD5"/>
    <dbReference type="GeneID" id="19895759"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02065"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_2_8_1"/>
    <dbReference type="OMA" id="EFAFYKT"/>
    <dbReference type="OrthoDB" id="423559at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF14">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="382"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="559" mass="65529" checksum="E49996F0FC7AF4B6" modified="2013-05-29" version="1">MGLGKTIQSIALIVSRKRPKCFQNIYSKSTLIVAPLSIIRQWESEISSKTNLSVLVYHGAERNKHSKNLKSYDVVITTYHILASEIKNAHGTNVLLEDKFNINSELFKISWWRLILDEAQIIKNKDSKIAIAACSLKGRNRWCLTGTPVQNSLDELYSLFKFLRIEPLNNFSVWKEQISKPMSQGNYELSIKRLRIVLNSIMIRRTKNILQKNDDKNDLLFLPKRIIKYEMIELDKHEREFYSKLELYIDKSLSRFLKNQIKGKNYTNMLCLLLRLRQACNHFELVKKKLALDKDAIDISNSFKHLSDINSLDNMISSFNSLELENNKNNKFRCDICLEKFFLENVNSKKDKCENCRKAFMKNPFFEDERSDIPKKLVISSKIRKMIEILQNKDNNLSDSNHKTIVFSQFTSMLDLVELFLKEEDIKFTRYDGSMPYYLRENALKKIRESEDIRVLLCSLKSGALGLNLTMANRVILLDIWWNPAIEEQAIDRVYRIGQTKDVIVYKIIAENTVEQRILILQERKKELIKDIFGDEKNKLTDINKLTLKDILFLFNHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLW0</accession>
    <name>M7NLW0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_03564</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875657.1">
        <property type="nucleotide sequence ID" value="XM_007877466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLW0"/>
    <dbReference type="STRING" id="1069680.M7NLW0"/>
    <dbReference type="GeneID" id="19897251"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03564"/>
    <dbReference type="eggNOG" id="KOG0706">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023062_7_0_1"/>
    <dbReference type="OMA" id="PANQVCF"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08831">
        <property type="entry name" value="ArfGap_ArfGap2_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="10"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="246"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR08126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="446" mass="50763" checksum="BB7D9DA884E3973F" modified="2013-05-29" version="1">MTHASKEESQKIFKNLRAQKYNQNCFDCGANGATWAATTFGIYICLDCSSIHRNLGVHISFVRSTILDLWTWDQLRIMKVGGNLSALEYFTKHGGTSILDSKDVKTKYTSKTAISYKDELKQRALLDSKSNSSIKIDDDEHSLISNDADDDFFTQWNDHMFQKSTLTCDTKTSFLDKTEINNTTKISNNHKDSMNSNLLKENSILNTSKLRSYVSTNKRTGITGPKLTKKLGAKKIAETFDFEEAEKNARKENNSNLSHTVKKNQIELEKDDLNNSNKSFSENSESDPKTNSSVKETTTGFQKLCFGQTKSTPKSIETNLSYKERSTTGNPCNDEITYARDNFFGQKSISSDKYFQRDLYNPAIQEETKLRLQAFNGAQSISSDQYYGENDTSTRDYKGFEESAKEYIQKFADTAYNDIENIREVLNHGAQKLSNILYEFGSRYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NM13</accession>
    <name>M7NM13_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Elongation factor 1 alpha-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_03405</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the Dom34-Hbs1 complex, also named Pelota-HBS1L complex, composed of dom34 and hbs1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875490.1">
        <property type="nucleotide sequence ID" value="XM_007877299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NM13"/>
    <dbReference type="STRING" id="1069680.M7NM13"/>
    <dbReference type="GeneID" id="19897092"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03405"/>
    <dbReference type="eggNOG" id="KOG0458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_3_2_1"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990533">
        <property type="term" value="C:Dom34-Hbs1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16267">
        <property type="entry name" value="HBS1-like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04093">
        <property type="entry name" value="HBS1_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000070">
        <property type="entry name" value="Translation elongation factor EF-1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000204">
        <property type="entry name" value="Translation elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015033">
        <property type="entry name" value="HBS1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08938">
        <property type="entry name" value="HBS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="359"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR08237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="785" mass="89056" checksum="C7507886FFDFF025" modified="2013-05-29" version="1">MSWRSYFGQELDDFSADNLEDFSQEELEKLTWTSAKVRERLKDVLHVKQKDIQEALKYCCFDIDKACSRIIEKKHLKEGLNINKTPSKKGFISFNNSSLNKEDLKSHFNLEVSSEENASETKEVSGPKQSKLIALASSKHKLSSNNPISSSLKSVSLLSHLTREKFKATNNRENNNNSSKIILDIQTNFAKPDVEKDLNLLKTTSEEDQKEEVIDDSLNVFFKKNCEYNIEVKPSKFALTIFGEKLELPDYFYKFANQRFSLFTGVLEDDLKISLNETFNNSLKSQKKKEKKLKTPSIVKSPIYSEIISNKDDLHHILNTLNISSEQGDKDETNYDKFYKLSESKNKISNLKTANIKNKPNVNIVIIGHVDAGKSTLIGRLLYDLKVVDTETIEKLKRETNKLGKPSFHFAWVLDQTSEERDRGVTMDLGINYFETSLRRYTILDTPGHKDFIPNMIAGASQADVALLVIDASYGSFESGFTAHGQTREHVILARSLGIQKIVVAINKLETTNWSQERYEDIMAQMLQFFIYKGFQKSNISFIPCSGLTGENLTNTIPLNPQLKLWYSNFTLLDTLENISINRQQLDTFLRLSIMDVYKSSNTLISVVGRIETGIINVGKEVIIMPSRKNGIIESIYIHDNLQDLAFSGDEVLINLLNIDLSYLKPGDIICDLENPVQIVSKFRAKIITFDLSRPLIIGTPLIIYRGRLNVDGNIKKLISIIDKSTGQVKKKDPKFIGSFDAAIVEIEFCKQAEAMESFKHCKELGRFIARSQGETVAAGIIEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NM56</accession>
    <name>M7NM56_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Adenylosuccinate lyase</fullName>
            <shortName evidence="12">ASL</shortName>
            <ecNumber evidence="6 12">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_03390</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = fumarate + AMP</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="6 12"/>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875474.1">
        <property type="nucleotide sequence ID" value="XM_007877283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NM56"/>
    <dbReference type="STRING" id="1069680.M7NM56"/>
    <dbReference type="GeneID" id="19897077"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03390"/>
    <dbReference type="eggNOG" id="KOG2700">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030949_1_1_1"/>
    <dbReference type="OMA" id="VQENAMK"/>
    <dbReference type="OrthoDB" id="406045at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03302">
        <property type="entry name" value="Adenylsuccinate_lyase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000005">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172:SF1">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenylosuccinate lyase C-terminal" evidence="13">
        <location>
            <begin position="382"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR08221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="490" mass="55846" checksum="F7814794CB6B39F9" modified="2013-05-29" version="1">MTHTIAPSGTSFDTYVTPFHERYSSPAMLSLFSQRNRINLWRKLWIDLATAQHEAGLKQISTSALKALKKHAEITEEEFEIARNEEQRCKHEVMAHIYTYTKVAPEASSILHLGATSCYVMDNADLIIMRDGLDILLNKLANVIHRLSKFCKSYKGLPILGYTHYQPAQLTTVGKRGALWLQDYVWDLRNLKRAREDLCFRGIKGTTGTQASFLALFDQDHDKVKQVETRVAELSGFNRTYVITGQTYPRKVDIDILGPLASFGASAHKMATDLRLLANEKQIEEPFDIGQIGSSAMAYKRNPMRSERICALARHLNVLYLNTTMTHSVQWFERTLDDSANRRICIPEAFLVADAILELLMNITSGLIVYPNVISKIIAKELPFMATENIIMAMVRKGGDRQMCHEKIRILSKEASRMVKEEGKDNDLIERIQRDVYFEPIWAELDTLLDPSTFIGRAPEQTEEFLNTQVEEALEPFRNQLTDREADLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMJ7</accession>
    <name>M7NMJ7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1279 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873620.1">
        <property type="nucleotide sequence ID" value="XM_007875429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMJ7"/>
    <dbReference type="STRING" id="1069680.M7NMJ7"/>
    <dbReference type="GeneID" id="19895353"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01659"/>
    <dbReference type="eggNOG" id="KOG4526">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1384683_0_0_1"/>
    <dbReference type="OMA" id="NEEASIW"/>
    <dbReference type="OrthoDB" id="426386at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045866">
        <property type="entry name" value="FAM210A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009688">
        <property type="entry name" value="FAM210A/B-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377:SF0">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06916">
        <property type="entry name" value="FAM210A-B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1279" evidence="2">
        <location>
            <begin position="75"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="197" mass="22695" checksum="D74E0987CCC131E1" modified="2013-05-29" version="1">MIISTIRLLKFQGSLFSFCSLYQKSKNPIFFCLNSSRKMQRLRVLRSSWMPYSTCKTEGMSVKEHYNKSKSFLERLRHLMRQYGIVGAYVYFSICLIDFGISLALVKSLGTTTIGFYEKKIISKIENFIDWRPKSSQSPLSGNSESRKNEEASIWTEIAIAYGIHKLLIFVRVPLAAALTPPLVRLLIRQGWLISKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN05</accession>
    <name>M7NN05_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-3-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.150</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Type III PIP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PNEG_03088</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57923"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.150"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.150" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875144.1">
        <property type="nucleotide sequence ID" value="XM_007876953.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NN05"/>
    <dbReference type="GeneID" id="19896775"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03088"/>
    <dbReference type="eggNOG" id="KOG0230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000480_3_1_1"/>
    <dbReference type="OMA" id="QSVWNDT"/>
    <dbReference type="OrthoDB" id="158357at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03334">
        <property type="entry name" value="Fab1_TCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15725">
        <property type="entry name" value="FYVE_PIKfyve_Fab1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17300">
        <property type="entry name" value="PIPKc_PIKfyve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.810.10:FF:000001">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase FAB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000007">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000005">
        <property type="entry name" value="1-phosphatidylinositol-3-phosphate 5-kinase (Fab1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044769">
        <property type="entry name" value="PIKfyve_PIPKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748:SF7">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="14">
        <location>
            <begin position="225"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="PIPK" evidence="15">
        <location>
            <begin position="1670"/>
            <end position="2006"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="910"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMR08612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="2024" mass="233609" checksum="E606D2E40EAD715D" modified="2013-05-29" version="1">MRLWADFLRKKSINSQDINVSGGLTSFKTLNVQKSDINEIEDRQSVEYFTETGNETGFSDRQDEINVLDEMYALGTHMCIPEKNLYKPNNGMYASNTSIYAGSNNSENTNVAASNPLKRLTALFLRKTKKGVGPVVDRISVLQDGVYTNIAGHSVQEDQILQGQVQGISVSGAQLPGFILQHDVSSDSEIIWVPPVEQSFRERSISMVLERLRTGRLGKDFWMKDENCRACFLCDAIFTAWRRRHHCRTCGQIFCSKCTTLIPGKSFGHIEDLRVCNRCHAIINEYIDVNGEEGNVFSEKPWLRSISQNVFRSNHFMEVFFPKKQSLDITFSPKNSEKSTCDVFDTLESMSPVSFGMSDMMDNNMSETNENYLASSLKSFNLDPTDDKWSVSKNEWKEGKRKNHVLHKRNHFAGLDIKSFSTTSGDMRKTSNRMVVSTPLIEENEHLSSTHSIPLPITSEKLQIVKMGKKNAIKIDRRLKKQKKIDGKHGNFSVSADYAKDIEFTSENAFFTSSFSALSKKKSHKVSPSDTSLKIMDSNSFPLYYIRELLKQLLRDSNVSSVLNWEQILTPMLFKIIDNINPNLRNGDDIDVRHYVKIKKIIGDPTLSCYVQGLVFTKKLALKKMNTSLINPRIVLITFPIEYHRTETHFMSLDPVIAQEKEYLRNLVNRIISLHPTILFVEKSVSGLAMQYLFESNIVVASNVKPSVIQAISRCTRADIISSIDKLALSPRIGKCAYFNLKTFVNSTSPIMKKTFIFLEGCPKDLGCTIILRGPTIHELSIVKRITELMVYVVYNLKLETCLMRDHFISLSDIPSNKLALDLLKDSYSTIDRNAPITSYDVIIEIFETRLLSASPYVKFPPPYMLLKARDSEKYLKEFLNDKKSDILDQKVHNFLKEMNALDNDHLLLNINLTEILKNAEIEKAQQELKIQEKNWQSYFVQDIGVASPFSHQGFAVLYSSVCTASAIPCKGPGMNIIEYYRETDCTLGQYIEDMCSTVNIICNANLCGRRLFEHHRSYVHDHARITVFIQELDHAISEIQKNIFLWSQCKICKKSTPMIPMSENTWKYSFGKYLELIFYNISLYSKTGICNHDINRDHIRYFGYQNFAVRFQFDYIELYDLSLPRAEIIWKSEGWIRLKLEEYNSIKSKIEKFCDSVEVRLNSIPLDTIPLDKFEGCKLEIDRFRKRIKDERAFLLIFLKESYENSHPLKILPLNRVLRSIQEMVIQWDVDFSEFDKDFFPSEKDMRRFTSLHLKKFFMDKELISDHNYSKGLEVSENLNSEVGDKLLRNKNRLLLLKKVSSEKDLNFMSSSESELSLNKNNSDTNISHFTKNALEVSNKKQDIFIKNTYNQINNELVQEIRKLSSDNNNFSKKKESDNNAEETNLNKVINTGNEVLFDNNNFSDSFQKLDIEKFDNSLPTSSIGSFLFKNYFFRKNFAKILNSDQKKPDCNYKKDLRSTLRTKKDLDIQFKSQNSEKFNGNISNFSNDFDPLDKEFEKQRTHKRRLKIKKNYSFLPSSKPIVEVFQNVQEAVNETSDDDLINEHKKINIDLKKKDKCELNSDKKGKKRIRRSQTIDSFNLYENKMGLENSQKDSDLSSLEILYTSPECFKFSNDDIIDEIPTHGAERISLMKSLFAFWADRASVGWSALNYPLNPYEHVFTDSDVIIREDEPSSLIAFTLSSVDYLNKLKEMEHIKALHNIIENSKTEEKLKDLGDLTKKPLENALLKLTGTHLKYQFQEGSAQLFCKVFYAEQFDAFRRACKCDEDYLSSLSRCFKWDSSGGKSGSAFLKTRDDRLVLKQLSRLETEAFIKFAPSYFEYMSQAFFHELPTAMAKIIGFYQIGSRNPHTGKVTKMDVLVTENLFYGKKTSRIFDLKGSMRNRHVQSTGKENEVLLDENLVEFIYDSPLFIREHFKKILRASLWNDTLFLAKMNVMDYSMVVGIDDERQELVVGIIDCIRTYTWDKKLESWVKEKGLVGGGGKEPTVVTPRQYKNRFREAMDSYIYGSPSCWYFFESALGLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN73</accession>
    <name>M7NN73_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_03048</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875103.1">
        <property type="nucleotide sequence ID" value="XM_007876912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN73"/>
    <dbReference type="STRING" id="1069680.M7NN73"/>
    <dbReference type="GeneID" id="19896735"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03048"/>
    <dbReference type="eggNOG" id="KOG0737">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004223_1_0_1"/>
    <dbReference type="OrthoDB" id="39734at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056027">
        <property type="entry name" value="DUF7608"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF56">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24581">
        <property type="entry name" value="DUF7608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="663"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="931" mass="106766" checksum="428B90518DC1AB47" modified="2013-05-29" version="1">MINSAKMKRLSYTRCYLCFFLFSKFEKPRIYEFYELKYKYKSSLTRFSTYSRVLQSNPKKSDVSDSLKSEIEAYENFHKGESDNLSLKRPASLLGTFSKNRRRATHRERRSGVAVRYSYEPEIPDWFLEKNVFLYGSIKSKKTEFKLNNNFSDPDLYNINVLEDTFAVTKNLILELISHLNTSFILNPEKKNENNSSRKANLMLTCPIKGSIYFLDAIVHEISNLLEADLIKISPQDLEDLVGDIFEEDRIGIFNSKTFGNLSFAGQNKKLLIQENEEIDEEDEETEGDDDISGVNLNHSVGKKIVLGPVLQILTASLPKSPNNTGFQDINKTLKPTQNNIGFHGKLSLILSKLSISNLEKQKKLFSSTLSTEKTNTFSQNKTIIYVQEYSSLINSISGNYVLKILREAIHARRKKGENIVIIAGSHKENIEHPNSVLCDDILLTIDQFYRNIFIVPVVKSKNQDNLNIDETFIKHKARRIKEINIRHLNSLLRRRCGIKFELDISKFLDSDSELFPNIQDEIWSFDFIHRIISIAIGLYKNSKDKQETISLDILDLSNAMKLIKENDELKESWKATLKYQQEKWKQRQFEDKKEEKFINFNNLDCNKYEKRLLPGVVNPEMITVGFESVRVPSSTKNILQTLISLPLKEPDAFNFGVLSHNRISGVLLFGPPGSGKTLLAKAIAKDCGARVLEIKGSEIFNMYVGEGEKNVKAIFSLARKLNPCVVFIDEVDAIFASRKSDYNNPSHREVINQFMSEWDGLVSQNSGVIIMGATNRPFDLDEAIIRRMPKRILVDLPTEEDRKEILKIHLKDETLAKDVDFDELSQKTVFFSGSDLKNLCVSAALESINENLQNNNSKKPYSRILKKSHFEKALNEITSSISDDMSSLIELRKWDEKYGKKKNIIRKTWGFGDINVSDSLKGRVRKPDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNX6</accession>
    <name>M7NNX6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein ERB1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic ribosome biogenesis protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ERB1</name>
        <name evidence="9" type="ORF">PNEG_01118</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat BOP1/ERB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873033.1">
        <property type="nucleotide sequence ID" value="XM_007874842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNX6"/>
    <dbReference type="STRING" id="1069680.M7NNX6"/>
    <dbReference type="GeneID" id="19894815"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01118"/>
    <dbReference type="eggNOG" id="KOG0650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011390_0_1_1"/>
    <dbReference type="OMA" id="MRPAKGE"/>
    <dbReference type="OrthoDB" id="5571054at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000061">
        <property type="entry name" value="Ribosome biogenesis protein BOP1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03027">
        <property type="entry name" value="BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BOP1 N-terminal" evidence="8">
        <location>
            <begin position="104"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="368"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="686"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="711" mass="82166" checksum="92607588DC20EE44" modified="2013-05-29" version="1">MSFDLNIGEKEKDVADNKEILFNEKDDSQWELLSTSTFDTEDISGEDDKNEDKKIKNYVSSYKEAVPGKKKYQEKYPEIIPGYGSDSSTEETFNTIGNISLEKYENFPHIGYDINGKKIMRPITKTALDRLLNTIEDNEGWTGIIDKDTGEDIRLTSEELEIVKKIQEMEIPDDDFNPYEMYVDYFSGKQEKTPLSSAPEPKRRFIPSKNERKKIMKIVQAIRTGRIVLSKSKEKIKQPLFYDIWTDTSLKSYDHIMHIPAPKIPLPTHDESYNPPEEYLPSEDEINKWNNTSYEDREKKYLPSKYKSLRLVPGYNQFIQERFERCLDLYLAPRVRKNRLNINPESLIPKLPLLEDLRPFPTRCMIIYEGHKGSIHSIDVDSTGTWLASGGDDGIVRIWEIITGREIWNFNCNDNSESINSIAWRPVKNSDIIIASCGNNIYMLLPSIFNDSIKNSAKELCNLGFDMEKFQTKQNLSTWLKPNFKQIDKGLLVLLNIKKRIKQVTWHRNGDYFATVSPESGNTSVLVHLLSKHQSQSPFKKVKGIIQKVEFHPTKPLFFAATQRYVKVYNLIKQELIKIIQPGVKWISCIDIHPQGDNIIIGSYDKKLIWVDMDLSSKPYKTLCYHAKALKSVKFHKGQYPLFCSTSDDGTIQVFHGMVYNDLMENALLVPLKILKGHEIKNSLGVFNAQWHPKQPWLFSCGVDATIRLWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP27</accession>
    <name>M7NP27_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosidase 2 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01177</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873092.1">
        <property type="nucleotide sequence ID" value="XM_007874901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP27"/>
    <dbReference type="STRING" id="1069680.M7NP27"/>
    <dbReference type="GeneID" id="19894874"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01177"/>
    <dbReference type="eggNOG" id="KOG2397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016834_2_1_1"/>
    <dbReference type="OMA" id="KHESASH"/>
    <dbReference type="OrthoDB" id="28322at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036607">
        <property type="entry name" value="PRKCSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028146">
        <property type="entry name" value="PRKCSH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630:SF1">
        <property type="entry name" value="GLUCOSIDASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12999">
        <property type="entry name" value="PRKCSH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13015">
        <property type="entry name" value="PRKCSH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082326" description="Glucosidase 2 subunit beta" evidence="6">
        <location>
            <begin position="17"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="7">
        <location>
            <begin position="370"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="487" mass="57892" checksum="D1809944C7BA5766" modified="2013-05-29" version="1">MKALCLFFICFFIVSGKIDPLRGVPESRKHLYRDEGGMWKCLNTSQYISFSRINDDWCDCEDGSDEPGTSACNNGMFFCENFGHISRFIPSSYVNDGICDCCDGSDEYEHIIECENTCEEQHKKYSQELANKDYIYKKGSRIRQEWAKKMKSMDKKLDDEIKDILNKLKDAIRKNRESKRSKIFENLKMFQTENTSFLGVLNEKIGDIFEKHKNKLSSFMYLWQDKIDIFDETLRNLKKIYDYDPSNIILDNVIKSLEEVKSDLDFENNGYNEYIEELKDEYNKFFEFIHREYHLFRFKERSFFGSVEDWIKRRIDQIKRCLISHKILIDDEKIDPQIIDDYDASGESNQEIDELREKLGKKELLRKEKSKFFNVYYAVKDEIITFKFKDYIYEFSFLKDAYQISTNDNNRILLGSFSHFDGHNKLYYYNGDRCWNGPSRSVMIELSCGIKNELISVMEYQRCVYFMKILTPGACILPSNEIKRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP28</accession>
    <name>M7NP28_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_02795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874828.1">
        <property type="nucleotide sequence ID" value="XM_007876637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP28"/>
    <dbReference type="GeneID" id="19896484"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02795"/>
    <dbReference type="HOGENOM" id="CLU_2264858_0_0_1"/>
    <dbReference type="OrthoDB" id="5421175at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR09022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="103" mass="12107" checksum="6DA5FC95EA2F4F5E" modified="2013-05-29" version="1">MKKTKSSRLKSSSDKIAGNEGDLIQKNIKIPINNHSLKKIHKKKTSLSYDSKINKSKREDIYLLKKDNPNLAPPMDLSLYNLRYSLLYEKKRIQRRSIPKYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP79</accession>
    <name>M7NP79_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA repair metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02837</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874873.1">
        <property type="nucleotide sequence ID" value="XM_007876682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP79"/>
    <dbReference type="STRING" id="1069680.M7NP79"/>
    <dbReference type="GeneID" id="19896526"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02837"/>
    <dbReference type="eggNOG" id="KOG1361">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005260_4_1_1"/>
    <dbReference type="OMA" id="KSGPIYC"/>
    <dbReference type="OrthoDB" id="262529at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16273">
        <property type="entry name" value="SNM1A-1C-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF6">
        <property type="entry name" value="DNA CROSS-LINK REPAIR 1A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="367"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="525" mass="61193" checksum="3A852A6F42473F8A" modified="2013-05-29" version="1">MFLENIQRTFENFDDKKTLSNKFNCPICFQYYTEKEFDTHVNNCFKVTQESNPSFYDDIDKNMTISSKRTYIEENNLNKISKINTISTNTLKKYDTKRSITKVFKNQKLHLKKRTLNKICQFYKIMPHTGFSVDAFEFGKIEGCIGYFLSHFHSDHYKGLTRHWNNGLIYCSEITGNLVISQLKVKPEYVVKLPMDRKILLNNIWVTLVDANHCPGSVLFIFEFEKSGKSMRYLHCGDFRACPSQISHSAIKNKHFDFLYLDTTYFNPKYLFPSQETVINAAIEICKILNNNFINNDFPEKRKSLNLDNFLVSTNITHKNQHRLLILINTYIIGKEKLALGIANSLKSKIYANQYKQKIISCLENEKLSSLLTSDPSEASVHLVNFKNMSVETLNRYLIEQKPHFSKIVGFNATGRTSVFLKSRFIDFSNIHSTIKDWKISYNYTMIKSNKDSTNTSICYSIPYSEHSSFKELICFCLSIDVDKIFPTVNIHTQKSRDSMEKWINLLENEKKKNGLLSLPSDQIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPB0</accession>
    <name>M7NPB0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase III subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01254</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC7 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873177.1">
        <property type="nucleotide sequence ID" value="XM_007874986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPB0"/>
    <dbReference type="STRING" id="1069680.M7NPB0"/>
    <dbReference type="GeneID" id="19894951"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01254"/>
    <dbReference type="eggNOG" id="ENOG502SEZJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1454995_0_0_1"/>
    <dbReference type="OrthoDB" id="5412082at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024661">
        <property type="entry name" value="RNA_pol_III_Rpc31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11705">
        <property type="entry name" value="RNA_pol_3_Rpc31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="137"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="146"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR10548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="22187" checksum="9C02500D4432947C" modified="2013-05-29" version="1">MFFMSSSEGISYINENYIDEKAYVQYYKELHTKISKESPFYISMSKGIDKDVSDYVEKYSDKYKPVPKMTQSLFFLKLEPLFFPEELFDVFLKEYKDAVYKEKVKEPVVLPFLEGFPNIFEEEMRELHECDSDIVEECESRKEDGNDQDEDFDDDDNNDYEDNYFDPGDEDYEDGSFSRDNVGDYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPH7</accession>
    <name>M7NPH7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PITH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PITHD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874512.1">
        <property type="nucleotide sequence ID" value="XM_007876321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPH7"/>
    <dbReference type="STRING" id="1069680.M7NPH7"/>
    <dbReference type="GeneID" id="19896194"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02502"/>
    <dbReference type="eggNOG" id="KOG1730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072377_2_0_1"/>
    <dbReference type="OMA" id="RLVFKPW"/>
    <dbReference type="OrthoDB" id="2635at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
        <property type="entry name" value="PITH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF1">
        <property type="entry name" value="PITH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="2">
        <location>
            <begin position="8"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="207" mass="23901" checksum="45E66896A9DA4EC0" modified="2013-05-29" version="1">MPHNTTCIHEVQEEHASWLFPHINLDGICTFNEVKQGMGRSIVKPWSNRFDTTKILESDTDDQLILYIPFTGIVKLKSFVLRCFPDLTAPKRCEIFMNREDVDFDTIESLKPIQSIDLVAPENAGEIIEYPVKTQFYGSCRNITLFFPSNWSIEMNQTRICLLGFKGIWSELRKQPVITIYEAAPNPMDHIHEQTIDASPHNNLFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPQ0</accession>
    <name>M7NPQ0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_02427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874433.1">
        <property type="nucleotide sequence ID" value="XM_007876242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPQ0"/>
    <dbReference type="STRING" id="1069680.M7NPQ0"/>
    <dbReference type="GeneID" id="19896120"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02427"/>
    <dbReference type="eggNOG" id="ENOG502SSAU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_586761_0_0_1"/>
    <dbReference type="OMA" id="ISHIAWH"/>
    <dbReference type="OrthoDB" id="10251741at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045139">
        <property type="entry name" value="Aladin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14494:SF0">
        <property type="entry name" value="ALADIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14494">
        <property type="entry name" value="ALADIN/ADRACALIN/AAAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR09081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="52572" checksum="A07FDF92C8AF79EF" modified="2013-05-29" version="1">MKNKFKEACLCSGITVAELNGKLITLKSSNDLKGLQELSNSEIMIFPVLSLPLLLDINRTYKKENISKKKSNNLYISEIFQLFKLIFQTLQIIPQTPLDLWFRSDKKLKSNTPVLISHIAWHKVIPIIALSHLKGMIYIYDFRNNSYFKYHLSSPPFTSITCLAFSNQNRLIVGYDNGQLVLWTLDLSITSTSNKIKAYCKQLILVKPSYFSEFPCGSITDLSFSQTGRQIFITTSKGAWVYDLIFSQAQRISFSRCFKIALTSSGSHCFVALGTENSIEIFSCLNSGPGLRFSPPLYISTSEVDKLIWAHDDKTLFYHILGSSTIEIVYVSPAILADTPPISRKIPTVIALQSEFNRPEPISNFVLDSSSERLILCFEKRSYLASFQVYLDAVLMTNNVSIVSPIGLIYGPDTDKNKNIGPIDMQFAPKFVGGALLATIWNDRVTFLPMKFPSKIEIDEFSKDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPS0</accession>
    <name>M7NPS0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00854</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872763.1">
        <property type="nucleotide sequence ID" value="XM_007874572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPS0"/>
    <dbReference type="STRING" id="1069680.M7NPS0"/>
    <dbReference type="GeneID" id="19894552"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00854"/>
    <dbReference type="eggNOG" id="KOG1464">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028981_0_1_1"/>
    <dbReference type="OMA" id="SEENWKD"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000006">
        <property type="entry name" value="COP9 signalosome complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="237"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="433" mass="51310" checksum="2E468459F11F4F43" modified="2013-05-29" version="1">MEDFMAEDQDFYFEDEEEPEADIENMYYHAKTIKNEPMQAIEEFKQVVRLETTKGIWGFRSYKQIMKLLFKLGKKNDVIAYYKELLTYTKSSVTKNYSEKSIHNILDYVSLDNDMKFMEEICSITLNFLKEIKNERLWLKTNLKLAKLWLEKKEYIRLNKILKQLYNVCENHDGSIDQSKSAYLLEVYSLGIQMYSETKNNKRLKELYHQTLKIKSAIIHPYTMGVIRECGGKMHMEEKQWQKAQTDFFESFKNYDEAGSHHRIRVLKYLVLANMLNGSNINPFDSQETNPYKNNSQLLSIIDLINAYQENDIYKIESILKDHYDEIMGDSFIQTYIDDILKNIRSQILIRLILPYTRISISFIGKKLNITSSDVEALLVNLILDGRIKGKIDQVNQILTLEKTEDPNRKKYEAINELADSINNLWKFYFYEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPV4</accession>
    <name>M7NPV4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Very-long-chain 3-oxoacyl-CoA reductase</fullName>
            <ecNumber evidence="12">1.1.1.330</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">3-ketoacyl-CoA reductase</fullName>
            <shortName evidence="12">3-ketoreductase</shortName>
            <shortName evidence="12">KAR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Microsomal beta-keto-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_00887</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="EC" id="1.1.1.330"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endoplasmic reticulum membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.330" evidence="12"/>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872798.1">
        <property type="nucleotide sequence ID" value="XM_007874607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPV4"/>
    <dbReference type="STRING" id="1069680.M7NPV4"/>
    <dbReference type="GeneID" id="19894585"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00887"/>
    <dbReference type="eggNOG" id="KOG1014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_38_0_1"/>
    <dbReference type="OMA" id="LVAPGMM"/>
    <dbReference type="OrthoDB" id="5545019at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045703">
        <property type="term" value="F:ketoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141040">
        <property type="term" value="F:very-long-chain 3-oxoacyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000137">
        <property type="entry name" value="Hydroxysteroid (17-beta) dehydrogenase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03107">
        <property type="entry name" value="3_ketoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027533">
        <property type="entry name" value="3_ketoreductase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086:SF2">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086">
        <property type="entry name" value="VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0521">NADP</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR10738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="335" mass="37778" checksum="975763B004D39BD1" modified="2013-05-29" version="1">MVFSLIFEIFEEYQKVGFFFRFISIIGIFSLFSAILSVKRLVFEIFFSKGIDVKTFQTRSGAWAIITGASEGIGREFSLQLSRYYFNVVLIARSKDKLEALSKEIESLYSVKTIVHIMDFSTANAREYEVLKEIIEDLDIKILVNNVGLSHTMPTPFSLTTPKEIQDITTINCIATLKVTNLVIPGMIRRKSGLILTMGSFSGIMPTPLLATYSGSKAFLITWSQALAEELKHDGITVQIINSYFVVSSMSKIKKSSFFIPTPKQFVNSVLNSIGLQRGAATPYTMTPYPSHSILNWLLENVAFKLSRSLVLKQNFKELQKIRRKALQKLNTSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPV6</accession>
    <name>M7NPV6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02607</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874621.1">
        <property type="nucleotide sequence ID" value="XM_007876430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPV6"/>
    <dbReference type="STRING" id="1069680.M7NPV6"/>
    <dbReference type="GeneID" id="19896299"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02607"/>
    <dbReference type="eggNOG" id="KOG0990">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042324_2_0_1"/>
    <dbReference type="OMA" id="AEDNLPW"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000028">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000004">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000129">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF9">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="70"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR09272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="358" mass="40696" checksum="BDEE550853E0C020" modified="2013-05-29" version="1">MDIDYESIVNDKLSIQNNKSYKGKETITYNIKQNDDILPWVEKYRPESLKGIVSHQDIILTIEKFIEKNRIPHLLFYGPPGTGKTSTILACAKKIYGPKFRNQLLELNASNERGIDVVREQIKNFASTKQIFNSGFKLIILDEADAMTLAAQNALRRVIEKYTKNVRFCIICNYVNKISPAIQSRCTRFRFQPLASKEIHSRLNYVIEKENINISEKGKTALVNLTHGDMRKGLNILQACHAAYDFIDEDAIYNCLGNPHPEIIELMVKSILNDELLNCLNTITRLKTERGLALLDIITRVHETLDELELPVNVQSHILDSLATIEYRLSSGASEKIQLSAMIGSIKMAVDLAEKMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ24</accession>
    <name>M7NQ24_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3020 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874311.1">
        <property type="nucleotide sequence ID" value="XM_007876120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ24"/>
    <dbReference type="STRING" id="1069680.M7NQ24"/>
    <dbReference type="GeneID" id="19896005"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02312"/>
    <dbReference type="eggNOG" id="ENOG502S97X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_909500_0_0_1"/>
    <dbReference type="OrthoDB" id="5595797at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021386">
        <property type="entry name" value="SPP41_DUF3020"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11223">
        <property type="entry name" value="DUF3020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3020" evidence="1">
        <location>
            <begin position="68"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="306" mass="35082" checksum="CFC125E233A20620" modified="2013-05-29" version="1">MGEKIVLSRDLAASSSVSFTGMGCMGEEAVKLAEHEDKNDILKLTTSNSELLVNVERNSMMEKIRQENRERKKRWRQANEDRNKDNDLRCRVNKRAHKLYGKEQSLAKSKWIEDEFLRRQLKRKDRERKRFLESHIMTTNRDINNTGFNAVEFSQTFLTNLFQNLVSFNHTIPFSFRSALFSFSTNPNFLRIITTLFASLTDNISSTPQIESSLENSHPTDDATQLYRSLLFNLLPSNNDSFFFSSSSIFLPSENVHNALNTNQSSSSAIYSLSSTTSQPSFTYRSSDPITSMGFPPVPVDFSQHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQ85</accession>
    <name>M7NQ85_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNL-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874375.1">
        <property type="nucleotide sequence ID" value="XM_007876184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQ85"/>
    <dbReference type="STRING" id="1069680.M7NQ85"/>
    <dbReference type="GeneID" id="19896063"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02370"/>
    <dbReference type="eggNOG" id="KOG3277">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1807017_0_0_1"/>
    <dbReference type="OrthoDB" id="512667at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024158">
        <property type="entry name" value="Mt_import_TIM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007853">
        <property type="entry name" value="Znf_DNL-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922:SF13">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05180">
        <property type="entry name" value="zf-DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51501">
        <property type="entry name" value="ZF_DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNL-type" evidence="5">
        <location>
            <begin position="43"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="143" mass="17012" checksum="55A63CB23C00660B" modified="2013-05-29" version="1">MFFYLKKINISRKFENKHFFIKTLNSILFFRQKGIGTLKCGYEKTPSYFITFTCQRCLSRTTHRMTKQAYHNGTVIIQCPRCKNRHLISDHLKIFSDKNITIEDIMKEKGEKVCKYYGEFANNQVVESVDKDIKLLLERPKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQA4</accession>
    <name>M7NQA4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Chaperone DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_02395</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874400.1">
        <property type="nucleotide sequence ID" value="XM_007876209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQA4"/>
    <dbReference type="STRING" id="1069680.M7NQA4"/>
    <dbReference type="GeneID" id="19896088"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02395"/>
    <dbReference type="eggNOG" id="KOG0712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_0_2_1"/>
    <dbReference type="OMA" id="KWHEDGD"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000002">
        <property type="entry name" value="Molecular chaperone DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082206" description="Chaperone DnaJ" evidence="7">
        <location>
            <begin position="24"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="26"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="141"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="141"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR09452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="43500" checksum="D1E38D6235780F5B" modified="2013-05-29" version="1">MHVRHILSLIFSCIYFFFSFICAETDYYKILEVDRNANIKELKKAYLRLSKKWHPDKNGGDEKKFRDLSHAYEVLSNPEKRKIYDMRGEEGLKAHEEYGDAQYHDAFDIFSKFFQGGFHEEKKGPDIRKDIELELEVLYYGGIHIIDIDKEVLCNYCKGSGRDPKHKNSLARCSQCNGKGTQLIRQMIAPGMFQTFQVICNSCSGQGHVISHPCTLCNGKKVLRKNEKYTLNIPPGAPYGYQFVFENEANESPNWVAGDLYIVIVEKPYSKSGWRRKNSDLYRTETISLSNALLGDWSRRIKLFNNEYFNITKPAGHIVQSGHVDVFPQKGMPVWNSLEKSSHLSRGNVYIEWRVILPELKLNDPLRKKLAKILKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQA6</accession>
    <name>M7NQA6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">deoxyhypusine synthase</fullName>
            <ecNumber evidence="6">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_02595</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="6"/>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874610.1">
        <property type="nucleotide sequence ID" value="XM_007876419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQA6"/>
    <dbReference type="STRING" id="1069680.M7NQA6"/>
    <dbReference type="GeneID" id="19896287"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02595"/>
    <dbReference type="eggNOG" id="KOG2924">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039781_0_0_1"/>
    <dbReference type="OMA" id="HSIINAN"/>
    <dbReference type="OrthoDB" id="294378at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.910.10:FF:000001">
        <property type="entry name" value="Probable deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00321">
        <property type="entry name" value="dhys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR09261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="369" mass="41443" checksum="8A27F325A907F4DA" modified="2013-05-29" version="1">MNNSLDIIKKSEEFEISKASVLIHSEPIFKNAVRVVGLDHNKYSSNKKADATNLTIEDLVESMYTTGFQATNFALAVNIINEMKNWRLPDELLEKEEYTYLENKKEGCTIFLGYTSNLVSSGVRESIRYLVQHKKVSCIVTTAGGVEEDIIKCLDHTYLGSFELDGSELRKKGLNRIGNLLIPNNNYCKFEDWIIPILDTLLEEQKKENKIWTPSSIIHRLGKEINSEESICYWAYKNEIPIFCPALTDGSMGDMIYFHSFRNPGLIIDIASDIRSINTISVRAKCTGMIILGGGIVKHHIANANLMRNGADYAVYINTEQEFDGSDSGARPDEAVSWGKIKSDAKMVKLYTDASIVFPLIVAVTFAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQD6</accession>
    <name>M7NQD6_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_02256</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874245.1">
        <property type="nucleotide sequence ID" value="XM_007876054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQD6"/>
    <dbReference type="STRING" id="1069680.M7NQD6"/>
    <dbReference type="GeneID" id="19895949"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02256"/>
    <dbReference type="eggNOG" id="KOG1082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020840_8_2_1"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043494">
        <property type="term" value="C:CLRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140720">
        <property type="term" value="C:subtelomeric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046974">
        <property type="term" value="F:histone H3K9 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061649">
        <property type="term" value="F:ubiquitin-modified histone reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033562">
        <property type="term" value="P:co-transcriptional gene silencing by RNA interference machinery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902794">
        <property type="term" value="P:siRNA-independent facultative heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd20073">
        <property type="entry name" value="SET_SUV39H_Clr4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050973">
        <property type="entry name" value="H3K9_Histone-Lys_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00468">
        <property type="entry name" value="PreSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Chromo" evidence="8">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-SET" evidence="10">
        <location>
            <begin position="359"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="427"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="11">
        <location>
            <begin position="577"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR09296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="594" mass="68689" checksum="15EC3F52E181691A" modified="2013-05-29" version="1">MLKKNNKENIKKDKIEPLDGEIYEVEKICEEFIQEDGNILYRISWKGYSEDFDTWEPIENLIDCENALEDWNRLKNSTALKKKQTLVSNKYIKKKEKNSEDFYCDDETSSVLLKKPFFLNNISKSDKTKDISIKKNKINNPNIKNIDNKKISDIEEDKSSFESNLNEGISFNTLNSLENNPLETFLMENPSVIFTNEKPHIVTKEKILQFRNKKKRKGALLSRSFVSSLQQKSSLLNEYSNNFEYITNDLPYIQTKENVKLNDLNKSSNHIIKATLFKGDFHKKSSKSKYIIKSKLNFTRPLSVRNNRKIFLEKLDMLLGPPVFLINEIDSDLSPIDFEFITSYKYGVGIEPRNPLFISGCSCPKDGCDLNNPGSCQCLEDSNNKSFSYDEYGRVRRNTTSIIYECNENCDCGINCPNRVVQRGRKIPLNIFKTKHKGWGLQCPRFIKEGTFIGVYLGELISQSEAEIRGKKYDHVGVTYLFDLDLFEDQVDEYYTIDAQYCGDVTRFINHSCDPNLAIYSVLRDKSDSKIYDLAFFAIKDIPALEELCFDYSGRNNEDQLGFIGNYSNSKYINLKNKRPCYCGSANCRGWLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRA3</accession>
    <name>M7NRA3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">GAR transformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02233</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6R)-10-formyltetrahydrofolate = N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6S)-5,6,7,8-tetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GART family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874218.1">
        <property type="nucleotide sequence ID" value="XM_007876027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRA3"/>
    <dbReference type="STRING" id="1069680.M7NRA3"/>
    <dbReference type="GeneID" id="19895926"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02233"/>
    <dbReference type="eggNOG" id="KOG3076">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038395_0_1_1"/>
    <dbReference type="OMA" id="HYVDEGM"/>
    <dbReference type="OrthoDB" id="5575075at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.170:FF:000009">
        <property type="entry name" value="Phosphoribosylglycinamide formyltransferase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369:SF2">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="10">
        <location>
            <begin position="14"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="221" mass="24732" checksum="5271207CBEC523FD" modified="2013-05-29" version="1">MDILLDSQKNTKNRLVVLISGSGTNLQAIIDACACQQINGYISRVISNTRSAYGIVRAEKVGIPITIHPLLPYKKKEEANLAGIEIARYKYDKDLSDIIIKEDPALVICAGWMHILSNACLDPLEKCGIKLINLHPALPATFDGMYAIERAYKAFCEGKIMKTGVMVHQVIEKIDRGEPIIVKEVPMLSNETFCQFEERMHKIEHEVIIEAILIILNSTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRE4</accession>
    <name>M7NRE4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongin-C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00322</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872195.1">
        <property type="nucleotide sequence ID" value="XM_007874004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRE4"/>
    <dbReference type="STRING" id="1069680.M7NRE4"/>
    <dbReference type="GeneID" id="19894020"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00322"/>
    <dbReference type="eggNOG" id="KOG3473">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130038_0_2_1"/>
    <dbReference type="OMA" id="AMVSPII"/>
    <dbReference type="OrthoDB" id="249087at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18321">
        <property type="entry name" value="BTB_POZ_EloC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000035">
        <property type="entry name" value="Elongin C transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039948">
        <property type="entry name" value="ELC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20648">
        <property type="entry name" value="ELONGIN-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="5">
        <location>
            <begin position="7"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR11293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="104" mass="12212" checksum="821FF7D4769D02F5" modified="2013-05-29" version="1">MSLKPEYIKLISSDDFIFVVKRSQACVSGIIREMLDESNQFLECKNNEIKFKTISAKLLYIVCQYFYFHEKYKNTESIPEFPIEPDIAIELLMISDFLDGNKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRF4</accession>
    <name>M7NRF4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01888</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873862.1">
        <property type="nucleotide sequence ID" value="XM_007875671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRF4"/>
    <dbReference type="STRING" id="1069680.M7NRF4"/>
    <dbReference type="GeneID" id="19895582"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01888"/>
    <dbReference type="eggNOG" id="KOG4336">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1246004_0_0_1"/>
    <dbReference type="OMA" id="LHRILAC"/>
    <dbReference type="OrthoDB" id="2193813at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08049">
        <property type="entry name" value="TAF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037818">
        <property type="entry name" value="TAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019473">
        <property type="entry name" value="TFIID_su8_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469:SF1">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10406">
        <property type="entry name" value="TAF8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor TFIID subunit 8 C-terminal" evidence="7">
        <location>
            <begin position="134"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="241" mass="28502" checksum="D0AE0BB1A9B260DD" modified="2013-05-29" version="1">MREESFERILGRRALVEILQSIGFSSAMKSSIMVLERFLVLYIMKILDRSLRFAFLQRRYKVSIYDIELMLLYEGIKIESLETEMKQRIGRNYELQKEESISKTSSHFMNTSSALIDKLLGPELTGINDKRPDYHLSHLPIFPPKHTYMSTPVYVQRMTCPHKIRELAAKQSRLAESALWKIIQIENKLNLNKIHQGPIKQDKLFLKVWKDMGYEEDACRPYEGLVNWETNRYTRQLRNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRH9</accession>
    <name>M7NRH9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01907</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873883.1">
        <property type="nucleotide sequence ID" value="XM_007875692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRH9"/>
    <dbReference type="STRING" id="1069680.M7NRH9"/>
    <dbReference type="GeneID" id="19895601"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01907"/>
    <dbReference type="eggNOG" id="KOG3283">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080597_1_1_1"/>
    <dbReference type="OMA" id="QRPHYRK"/>
    <dbReference type="OrthoDB" id="1703270at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11380">
        <property type="entry name" value="Ribosomal_S8e_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.168.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.168.20">
        <property type="entry name" value="Ribosomal protein S8e, subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_eS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018283">
        <property type="entry name" value="Ribosomal_eS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042563">
        <property type="entry name" value="Ribosomal_protein_eS8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01193">
        <property type="entry name" value="RIBOSOMAL_S8E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="206" mass="23647" checksum="A2E59CBF888B7E23" modified="2013-05-29" version="1">MGISRDSRHKRSATGAKRPHYRKKRKFELGRQPANTRIGPKRIHIIRVRGGNKKFRALRLDSGNFSWGSEAISRKTRIIQVVYHPSNNELVRTNTLTKSAIVQIDATPFRQWYESHYGQSIGKRQKKSDQTKDLEPVKRSAHVLAKIRMRARSAKIDVALENQFNNGRLYACVSSRPGQSGRCDGYILEGEELAFYLKRMSAKKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRJ3</accession>
    <name>M7NRJ3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar-sorting protein SNF7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar protein-sorting-associated protein 32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_01653</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873614.1">
        <property type="nucleotide sequence ID" value="XM_007875423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRJ3"/>
    <dbReference type="STRING" id="1069680.M7NRJ3"/>
    <dbReference type="GeneID" id="19895347"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01653"/>
    <dbReference type="eggNOG" id="KOG1656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071097_1_1_1"/>
    <dbReference type="OMA" id="RCPKEGL"/>
    <dbReference type="OrthoDB" id="5592979at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="156" mass="18036" checksum="EA9927CECBC5C430" modified="2013-05-29" version="1">MQALKRKKLLENEINKLMGIRMNLEQTLFTLENANINYEITKAMKQSTAAMKQISKGITPDKVDSIMDNIREQIDHHNEIGELIARPIGMSETFDENELNQELERIQQEELDEKMLGAEKPPTQLPGYNTEKYKEIIQTEDNDEAEIKALQEEMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRK0</accession>
    <name>M7NRK0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Myosin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PNEG_00390</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872264.1">
        <property type="nucleotide sequence ID" value="XM_007874073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRK0"/>
    <dbReference type="STRING" id="1069680.M7NRK0"/>
    <dbReference type="GeneID" id="19894088"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00390"/>
    <dbReference type="eggNOG" id="KOG0162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000192_7_6_1"/>
    <dbReference type="OMA" id="PPEEYQM"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045160">
        <property type="term" value="C:myosin I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044853">
        <property type="term" value="C:plasma membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11858">
        <property type="entry name" value="SH3_Myosin-I_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000004">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000007">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035535">
        <property type="entry name" value="Fungal_myosin-I_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF837">
        <property type="entry name" value="MYOSIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9 14" id="KW-0518">Myosin</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Myosin motor" evidence="16">
        <location>
            <begin position="46"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="17">
        <location>
            <begin position="781"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="15">
        <location>
            <begin position="1030"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="14">
        <location>
            <begin position="598"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="139"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMR11363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1088" mass="126065" checksum="B7605A3F4E71C7CE" modified="2013-05-29" version="1">MAIVRRDRSLEGFLHKNLDKNKSINNSKDNQVKKKTFYKEIKKKSIGVDDLTLLSKIGDETINDNLKKRFENKEIYTYIGHVLISVNPFQDLGIYTEEILHSYRGKNRLEEKPHVYAIAENAFYNMAAYKENQCIIISGESGAGKTEAAKRIMQYIASVSKGNSSQIQEIKNIVLATNPLLESFGCAKTLRNHNSSRHGKYLEIQFNSDSEPVGANITNYLLEKGRVISQIKNERNFHIFYQFTKSANQYYREMFGIQGPESYFYTGTSECLNVEGMDDSSDFLETCKAMETIGLTLSDKDNIFKMLSIILWLGNIQFQEDKEGNAVIYDDAVTKFIAYLMEVDEKSINKALTSRVLETQKSGRRRSIYDVPLNPLQANSTKDALAKSIYNNLFEWILKKINLSMKARGNISYTIGILDIYGFEIFENNSFEQICINYVNEKLQQIFVELTLKAEQEEYIREKIKWTPINYFNNKIVCDLVEAKYPPGIFAALNDAVATAHADSVAADSSFIQKLNLLTSNPHFEQRQSQFIIKHYAGDVTYTVHGMTEKNKDNLLKDLLNLIAKSENTFLHELFPEKVDNDSKKRPSTSADKIKLSANTLMDNLMKCQPSYIRTIKPNSNRSPTEYNEKEVLHQIKYLGLQENIRIRRAGFAYRQTFDKFVERFYLLSRKCSYAGEYIWKHSSRSACEQIFKDISVPNSEFQIGITKVFIKHPETLFSMESMRDKYWHNMAIRIQRAWRNYLKYRNECAIKIQRIWRKNKNIIYYIRLRNEGHRILGGRKERRIASLLYSRYFIGDYLDINSNGDLGKMYKKAININDLKVEFSCTIELLYSKLGRSSKTKPKDFIMTNKMIYIFATTVLNKQLNIFIERSIELNNVRCVLLSSLSDDWVCLKLDNKNEPDLFFSCVFKTELITRLKHILYNLNLQIGSTIEYNKRQGKISTVKFVINSKIPTNNIYKSGIVYVLPGEPSNSLPKTTLKKKTITCETPKINTSNLFTFKNSLTSETNSSNKKYISIPPFRKSPTPPINNLGPYYVALYDFQGQTSNEMSFKKDEILYIIHKETNGWWLARKDGLEGWVPKNYLKERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRM2</accession>
    <name>M7NRM2_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873644.1">
        <property type="nucleotide sequence ID" value="XM_007875453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRM2"/>
    <dbReference type="GeneID" id="19895375"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01681"/>
    <dbReference type="HOGENOM" id="CLU_642693_0_0_1"/>
    <dbReference type="OrthoDB" id="5292411at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR09922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="427" mass="49747" checksum="49D303E0077D5AB7" modified="2013-05-29" version="1">MTPKSQFYVDYVFKRSLGISQRNQHPEVPILKIDINTIDTPDKALRRDILLGTISSWPFYLVSVPKCTQNIPYFLHFFENETMFENIRERNENVNDTEEEEIRYEGDIHLWQLTPNEKVKLMKKITFKPLSINNIPIISLETIWDTTKHTLTQVLLRRYICVTDEMESMCGGWIEVRRVQLSPQNNILDMKSMAVPAGEGNIYNHACFSYLKYGLIPVLTNTRIIFFPYYHMNNYDDQTLYDNKVWPSSSSFELEIWSNTSSKELLPVVFELDLYIEKLLEDTNHCSSNIPVLNHFHAEFITSYKRKINNSSLLDFEGVTIIAGGLGKTILIVTQLRIIPWKRTVIPFNIKIWSLKTPARTPIKAIQAGFSFTLGKKLEVHNCHEHCINNKYKLMESYQNDGLGYSRSLKELRCEELGITLLNTGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRS7</accession>
    <name>M7NRS7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RRM Nup35-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_00471</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872354.1">
        <property type="nucleotide sequence ID" value="XM_007874163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRS7"/>
    <dbReference type="STRING" id="1069680.M7NRS7"/>
    <dbReference type="GeneID" id="19894169"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00471"/>
    <dbReference type="eggNOG" id="ENOG502QWFW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_752623_0_0_1"/>
    <dbReference type="OMA" id="MVGCIYS"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044615">
        <property type="term" value="C:nuclear pore nuclear basket"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12721">
        <property type="entry name" value="RRM_Nup53p_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007846">
        <property type="entry name" value="RRM_NUP35_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21527">
        <property type="entry name" value="NUCLEOPORIN NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21527:SF6">
        <property type="entry name" value="NUCLEOPORIN NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05172">
        <property type="entry name" value="RRM_Nup35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51472">
        <property type="entry name" value="RRM_NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6 8" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM Nup35-type" evidence="10">
        <location>
            <begin position="187"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="78"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR11453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="388" mass="42864" checksum="0F7ECA701A19D91F" modified="2013-05-29" version="1">MFSNETISTPLNNGSPLSIPSTISSIEPLGSPAIKSQNISLLNGHFRSPSLQEIYLSRNNTPDLSIGKRKYVPSHLSQLPYRKSYTPDRSSPLVSQPSFTARPSTSNIRKTSTSPPNWFGGPSFGTPKSNSRRGKAGHKIQEEEAPPVESLYDVEGNIIRDIEPNEVSENKFNSTPESIRAKELPKSSIPTAVILFGFPATLTSHVISHFSRYGEILDHSSTENPISTGSNWLKITYADEESASKAVSSNGTIIGGTYMVGCIFAPVEEPNTKTDKDMDMTMDLDAKTPSSHCSINPRHSITHISHQESPNIVLRTSSNTYKSNSCNGRRIEVLGSEGIFKETPDKTYSWITWSSINKPTTQEHQQTENKSQWTKKLVRGIMELLFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRW4</accession>
    <name>M7NRW4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_00506</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ZNF598/HEL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872394.1">
        <property type="nucleotide sequence ID" value="XM_007874203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRW4"/>
    <dbReference type="STRING" id="1069680.M7NRW4"/>
    <dbReference type="GeneID" id="19894204"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00506"/>
    <dbReference type="eggNOG" id="KOG2231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008515_1_1_1"/>
    <dbReference type="OMA" id="FHERCHV"/>
    <dbReference type="OrthoDB" id="3838338at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16615">
        <property type="entry name" value="RING-HC_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057634">
        <property type="entry name" value="PAH_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041888">
        <property type="entry name" value="RING-HC_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056437">
        <property type="entry name" value="Znf-C2H2_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23202">
        <property type="entry name" value="PAH_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25447">
        <property type="entry name" value="RING_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23230">
        <property type="entry name" value="zf-C2H2_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="14"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="296"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR11493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="580" mass="67526" checksum="F12085D7595FD418" modified="2013-05-29" version="1">MLKKKFMFNEFEICFICMESFTESSIPLCNHRICQKCSLRLRALYNNMNCAYCKTFQPNVIFSKGLMNYNDFELEKLSYKNDKLGIFFESSQLMEKVLSLLDFSCPEFDCNIVCNDWQDLKKHAKKIHEKYLCDLCVQNKKVFVHEHILFSKHDLVAHIKKGDFGNNRNKTGFKGHPDCGFCKRNFYDDDDLYKHCQEFHERCHVCDQMAGQLKHQYYLNYDSLEQHFRRDHYICLEVECLEKKFVVFGTEFDLKAHQLEVHKNNLSSKALKGARKIPMSLIFDCPKNFRNAKGKNVDTSNELQNYNEHMTRAERALKRQEENALRKLKDSGTFLGDTVSTNSSIQSIVAGPSNSHLYNCSVLDNLKDEEFPELGELSLLNKNNLNNIFLSSSFNYDSKIVSQYSVVLNNISGLFNDAEKTKHFWFGISEFSNSSITATQFVEFLWFLFNERLEEIGKVLSQIVNLIHNDDKKKELFIAWNDWKIKNQTGKTSTKITNGSYIGRNNSETFLGSSYTVNFPSLCSIEKKPTQCFHTKNISKSRNVWDFVDKKNIVAEKEKTELKMKGRKKNKKGTVIFHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRX5</accession>
    <name>M7NRX5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sterol 24-C-methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Delta(24)-sterol C-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01786</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of methyl groups from S-adenosyl-methionine to the C-24 of sterols.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Steroid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5 6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873754.1">
        <property type="nucleotide sequence ID" value="XM_007875563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRX5"/>
    <dbReference type="STRING" id="1069680.M7NRX5"/>
    <dbReference type="GeneID" id="19895480"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01786"/>
    <dbReference type="eggNOG" id="KOG1269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039068_5_3_1"/>
    <dbReference type="OMA" id="NGIATMM"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030384">
        <property type="entry name" value="MeTrfase_SMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013705">
        <property type="entry name" value="Sterol_MeTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08498">
        <property type="entry name" value="Sterol_MT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51685">
        <property type="entry name" value="SAM_MT_ERG6_SMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 5 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="6" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase Erg6/SMT-type" evidence="7">
        <location>
            <begin position="80"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="377" mass="43271" checksum="F227F236470B357F" modified="2013-05-29" version="1">MSFEPELIDIEKDREFSEIMHGKDAANERGLFSAFKKDKDAQKVALDSYFGFWSDKHLSEKNDFYRKERFRFYATLTRHYYNLVTDFYEYGWSTSFHFCRFAKDETFQQAIARHEHYIALHAGIREGEMVLDVGCGVGGPACQIAVFTGANIVGLNNNDYQIERAKYYSQKKGLTDKLRFVKGDFMQMPFTDNSFDKIYSIEATIHAPSLEGVYSEIYRVLKPGGIYASYEWVMLNKYDENNPEHQQIVYGIEIGDSIPKISKIGDAEAALIRVGFEIIHSEELSTKNSALPWYYYLEGDLRKARSFRDFIAIARMTTVGKWLVSSFIGLMEFIGLVPKGSKKVNDILLVAADSLVKGGKKEIFTPMQLWVCKKPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRZ9</accession>
    <name>M7NRZ9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major surface glycoprotein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01642</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09881.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873603.2">
        <property type="nucleotide sequence ID" value="XM_007875412.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRZ9"/>
    <dbReference type="STRING" id="1069680.M7NRZ9"/>
    <dbReference type="GeneID" id="19895336"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01642"/>
    <dbReference type="eggNOG" id="KOG3544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010455_0_0_1"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021041">
        <property type="entry name" value="Maj_surf_glycoprot_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003330">
        <property type="entry name" value="MSG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02349">
        <property type="entry name" value="MSG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12373">
        <property type="entry name" value="Msg2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006963415" description="Major surface glycoprotein 2 C-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="domain" description="Major surface glycoprotein 2 C-terminal" evidence="4">
        <location>
            <begin position="862"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="817"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1032"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="768"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="837"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="848"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1040"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09881.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1083" mass="123479" checksum="AF21E59F47B8781A" modified="2016-03-16" version="2">MINKIILIAILNLIALTYGNQSLDLSIRSSQAGSINPSFGSFIDEEEIYAFILKENYNDENKCKVKLEEYCKELKDIDPEFNKVDSKVKEICNNNNKGQKCKDLKTSLEKKLYKFNNEINNHLKSYPSGFGACSEYFKKCLLLGDINEPDTINTCNVIKYLCYINFTEKPKKQIIFRIVGESITNYDDFKEKMKKICPLFIQQGSDLLFNCLEIENSYKQFDTYMRYFCSFLNINLDDNLLKEKCYEELRNCYFFKNKCEEKCNKLKVLCEKKNITYRPPEKIFSPIEPEATFLEKIDIEGFYKEMRDKGNAIGFFKNTLDDMLIYLSTGVSGLEENKCKNLLKNNCSFFEFLSPEFKELCQDNKEQKCKDILEISDRCRKLKLILYLNGFSTEFEDNKLGKNIPWNKLSTSFNERECLKFTLECLFIRKSCKNNLIEGCINLQLACFKKQQERQFIKLIESKLVEEQYNLKSKDEKLKICQKIVMEKCVALLNSNIENFLKCLRPKEICLGLEEIIFVRSKELEQALDQARDFPKEEDCVELKKECEGILKDLGSNNVKCVTLKERCKYLEVTKELKYDFLKDKSDSLMNIQNCMKALKEKCDGLFKRETNAFGVSCALPEETCKFMVSEVENHCNAFKNNIEKHDIVNKSKNGNETLVEEICILWDPYCDELMENCPDKLKKGDNGNEKGVCLQLKENCRPFFEKLKLEDELTHELKGSLSNETECKKALGKHCSEQKNSGNQKFNSFCNTDKDKDVEEKACKKLVEKVKEKCPTLESELDKEKDELKKKKDEYEKVKQESEKFTKEAKLVLSRLGKDGQDAGSKVQNTSAAEPAAPPGGAPAPAVPGGSTPSGGANTNNVILVRRTFVSGEVSEAEKKAFVATTRALELYLELKEKCKGLQGDCGFRKDCPKCETVCTEIDKLCEGIEGLKVTPYYTVTSTAIQTTTTTAMTTTTTTTTTTTTTTTTTTATTTTTTTTESVDGGKVTEECTLVQTTDTWVTSTSLHTSTMTSTSTLTSTVTLTSMRKCKPTRCTSDSSKETETQKEEEKEEEVKPNEGMKIRVPEMIKIMLLGVIVMGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NS48</accession>
    <name>M7NS48_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873663.1">
        <property type="nucleotide sequence ID" value="XM_007875472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NS48"/>
    <dbReference type="STRING" id="1069680.M7NS48"/>
    <dbReference type="GeneID" id="19895394"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01700"/>
    <dbReference type="eggNOG" id="ENOG502QQ2N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007860_1_0_1"/>
    <dbReference type="OMA" id="IMALGCM"/>
    <dbReference type="OrthoDB" id="2427554at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07992">
        <property type="entry name" value="LPLAT_AAK14816-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="3">
        <location>
            <begin position="41"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR09941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="724" mass="82250" checksum="E457FD8CA64A143A" modified="2013-05-29" version="1">MDFANFTYDIILWMMTVLLDLFFREVKTRGSFRIPKRGGLIFVAAPHANQFVDPLLLMRQVQLASSRRIFFLIAEKSMRRKFVGFIARLAGSIPVARPFDYLKQGTGKIVLSTKNPMHAYGIGTVFTKELFKGSLIVISNIHNLEVVDIISDTEIILKEKTKEFSSISSDEDGLTFKIASKIDQNKVYSQIFKKLEEGKCIGIFPEGGSHDRSDLLPLKAGVAIMALGALANNPNIDIKIVPCGMNYFNAHRFRSSAVLEFGTPLEVPKELVEKYKSSCKYEAIKTLLDMIYNALMAVTVRTTDYETLMFIQAGRRLYKPGHRRLPLQQIVELNRRFIMGYNHYKDDPRVVKLRNSIVSYNRQLYLLGIRDHQVQSANYGVFKVITLLIYRFLKFLILAIVSFPGVIMFAPVFIATKIISKRKAKEALDASTVKIQGNDVLATWKLLVALALVPALLLFYSIIITYLTIHFQIVSYTKKWICIMLIVSLIIIFMVSFAALRFGESGLDIYKSLRPLFLSLNPTSANTIYKLRQTREELAVELTNLINTLGPELFPDFDPGKVAAISEYMVQNSRVGQSHSRSASFDKNDDALTNSTTLSYNSILDLSRNTSLQSLSSIQLFTNNSFSSSSKANSLIEDNEKERIDQDSISSKSESFEEVSKEIRKAMKQRIQKRKNRKPYIYSESCDFDISDESDYLKLHSSTSESESETRSESEYYEESKKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M7NS67</accession>
    <name>M7NS67_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873683.1">
        <property type="nucleotide sequence ID" value="XM_007875492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NS67"/>
    <dbReference type="GeneID" id="19895413"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01719"/>
    <dbReference type="HOGENOM" id="CLU_2484261_0_0_1"/>
    <dbReference type="OrthoDB" id="5387630at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019034">
        <property type="entry name" value="UPF0390"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09495">
        <property type="entry name" value="DUF2462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="87" mass="9972" checksum="F251D279E2280475" modified="2013-05-29" version="1">MTQGLTKLTKKSAKTRHKPVQLKRGARIISAKKASIRKAQNLQRMLTKSINEKNEAILAQRAGFSKNFSLIKKQKKNNLLFRTKHKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSE5</accession>
    <name>M7NSE5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotide exchange factor SIL1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00111</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with KAR2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871968.1">
        <property type="nucleotide sequence ID" value="XM_007873777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSE5"/>
    <dbReference type="STRING" id="1069680.M7NSE5"/>
    <dbReference type="GeneID" id="19893809"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00111"/>
    <dbReference type="eggNOG" id="KOG2160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034955_0_0_1"/>
    <dbReference type="OMA" id="GLDIRMN"/>
    <dbReference type="OrthoDB" id="448649at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031884">
        <property type="entry name" value="Sil1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF34">
        <property type="entry name" value="NUCLEOTIDE EXCHANGE FACTOR SIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16782">
        <property type="entry name" value="SIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082610" description="Nucleotide exchange factor SIL1" evidence="9">
        <location>
            <begin position="19"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="390" mass="45126" checksum="5C5BA0CB4941932D" modified="2013-05-29" version="1">MKWKNYLLLILISKFIYADKSKKMICHGKKECYPEVFEATNVFQVVHEDQILPPGLHIRLDFSTGIKEAKIIDENENDKNNVILVYQDGHIESTNIIKESPVFSHIAEIKPNLKISQVEHEEFSMALKLLISDKYNDSTEELINVLSVLEELSHEFEFGIKICKSRLAVERLIELLETSNSIFIKKLAITVLGSSVQNNPQALVYISDMKLTEVLLNRLQYEKDDGIKIKVLYTLSSIVKSSSGMNEFYMTHGDKILYEIFKKTQNPALISKCASFIEDNYFQDQNYNNDKFKTTSLSFSMYIDSIIKHWCEDFQLVLFRNELDTDSKEKILSALSILKKKHYSICKPVSGFLEFLNHETTLVYEKGHPYIGLLESIQHLFQTFGEEDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSE8</accession>
    <name>M7NSE8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VASt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873768.1">
        <property type="nucleotide sequence ID" value="XM_007875577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSE8"/>
    <dbReference type="STRING" id="1069680.M7NSE8"/>
    <dbReference type="GeneID" id="19895494"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01800"/>
    <dbReference type="eggNOG" id="KOG1032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_325194_0_0_1"/>
    <dbReference type="OrthoDB" id="2162691at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13220">
        <property type="entry name" value="PH-GRAM_GRAMDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="797"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="7">
        <location>
            <begin position="574"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="887" mass="101782" checksum="B63AFC35B3CB9D62" modified="2013-05-29" version="1">MNINTSISQTNCTLEKTLFFKRKLKKEKNSKTEKTNTRSKSSESILINNFTIQNNHENNTTSSILKNPEMKDKQLTHSSQSSFQSSILKKYISKTDDASTNDLFSKDRTSFQKSQSSINSYISNLKITECSDKTSDFETFLDLKTSSTQSINNVYGNDKNSTYNILTKESNSISSISEKSNTGFFNTVISAAQNAANSLTSLTTHKSSKDKNISEKLNGSRNSTRNNLGSITNEFVTQDFLEKKNKELAINIIPSIGSGKLSLNDVKISEDIDKSHVFADKECPDKELSNKKLEENLNNKFINYNFNQKKNHTSASSQILTHKKINSIIKKSGYSSASCLNRQNTIHLLIQQITGIAIANSKRNKEFHTLFKSIPEDSYLIDDYASALQKDILLHGRMYISEAYICFNSNIFGWITNLIISFSEIVSIDKKSTAIVFPNAIQITTLHAKYIFSSFISRDTTYDLLTSIWRLTNPSTRTSITEINIDDKNNENCEDLTKTRNLNDEDFETNNIQNNEGNNTNEDSIKKIDDETLCQNFSKKNYLTINDINLDIKSLEYTERQPTECSCLLRNEHYEKQICDEIIKGPLPEVVNLCFGEELAFMHNFLENVQKVSEIKLGKWKKDDSGKKIRHISYLKPLYAPVGPKQTHCKIVEMIEHEDNNYVTVSSITKTPDVPSGNSFVVKTKYCMMWDKNNYTRIIATCTTDWTKSSWLKSPIEKGANEGQISYIKDLIDTITNALKRPINEKYLEEKPTRKLQKLYKIRHSIDNKKNQIMCDKNNSDIKLKLFNKLKSAFNTILNIFLFVIKPNNITIVLLLMIFLKIAQLEKTFQNMTHLTNIDYKILNHYNSLWTQGEISEKCIKPEITYNFQIPKRYSSSFFDKKKRRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSI8</accession>
    <name>M7NSI8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01835</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873808.1">
        <property type="nucleotide sequence ID" value="XM_007875617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSI8"/>
    <dbReference type="STRING" id="1069680.M7NSI8"/>
    <dbReference type="GeneID" id="19895529"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01835"/>
    <dbReference type="eggNOG" id="KOG0182">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_4_1_1"/>
    <dbReference type="OMA" id="YGYDMPV"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03754">
        <property type="entry name" value="proteasome_alpha_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000026">
        <property type="entry name" value="Proteasome subunit alpha type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034642">
        <property type="entry name" value="Proteasome_subunit_alpha6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="254" mass="27912" checksum="C755EC94578D8764" modified="2013-05-29" version="1">MSRGSSTGYDRHITIFSPEGRLYQVEYAFKSVNSTGITSVAIKGKDSVVFISQKKVPDKLIDQDSVSYIFRITENIGCLVTGQIADARASVNRARVEAADFKYKYGYEIPVDVLAKRIANINQVCTQRAAMRPLGISSIFIAIDEEKGPQIFKCDLAGYYAGYKATASGPKKQEAINYLEKKLKSDGFEGSWIDITELAINTLSSVLNIDLKATEIEIGVVGASPKGSLKSSNIFRVLTTDEIDERLQSIAEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7NT42</accession>
    <name>M7NT42_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Far11/STRP C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01161</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873076.1">
        <property type="nucleotide sequence ID" value="XM_007874885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NT42"/>
    <dbReference type="STRING" id="1069680.M7NT42"/>
    <dbReference type="GeneID" id="19894858"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01161"/>
    <dbReference type="eggNOG" id="KOG3680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011008_1_0_1"/>
    <dbReference type="OMA" id="KMTRAMR"/>
    <dbReference type="OrthoDB" id="18234at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040185">
        <property type="entry name" value="Far11/STRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021819">
        <property type="entry name" value="Far11/STRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012486">
        <property type="entry name" value="Far11/STRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239:SF4">
        <property type="entry name" value="AT25231P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239">
        <property type="entry name" value="PROTEIN REQUIRED FOR HYPHAL ANASTOMOSIS HAM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11882">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07923">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01293">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01292">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Far11/STRP N-terminal" evidence="2">
        <location>
            <begin position="47"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Far11/STRP C-terminal" evidence="3">
        <location>
            <begin position="397"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="761" mass="90313" checksum="97428194E772E485" modified="2013-05-29" version="1">MSFLRENDPVIVENESEEGEEENELPRDSLTLVELKKIIYNVNEQKTVKYDFEYKDRDDLENELEEWYDYDDVAIIQGKKVFETFFCKEWINSKIKEKKEFICHQLEELDSKDPKIRTKSCFILFYISQGNYGETKNQQDQIYWILENNKILNECNALKILYDSIRKSVNLLNTYKPMIYEKINTFELDSITLLKVELNCKMTSFYFLLETFCSDLEFRKNVVDLSPPIISWMIEEIANLKINLSIWRLYFPIIQTIQILQKLILCVFGNTKDFSNLKRYLRMLSGLPPELNKKEIIATPLDYHIFRQNIISKYPTYEPPSTLLNIDLEYTTLLPIHKGETETKKMHKDSDSSVTEHYVTPLSSPYFSLKTKQSVFKKNQDLPFLLPLSDSFDLEIPTSIKEASELFKSKTHIDLSTIQLWEETEKFMRFERGWIKDNLDLTKESPSLDIQNDPLHDSRLNAIEVIYASLVSHLESFIYVMMKFLDFLIDDEQNYTKKDTEESKKENNNFDFFSPEKILHIRKREIASKSISSTLLLLLKSFKLSHVLKFEFLSQLILDSGYIDIFNKLCSLYDPVESISHISEIPYLSYFNTCNMQSRNSNKYSEIISDFSKDIKANDLENKETDNNIIIQFSRRNLFSLVNHLRILQKITKKKTYRNLVLIQKKTWTHLQKITKITNDIVQLYTLKIFKGQIPYYNKKWKQNNMKIITSIYLHCRPELQDDWVSGVEVDTNTEESLEYALRSLIRFYNYHHYSFPNQFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTI7</accession>
    <name>M7NTI7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01126</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873041.1">
        <property type="nucleotide sequence ID" value="XM_007874850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTI7"/>
    <dbReference type="STRING" id="1069680.M7NTI7"/>
    <dbReference type="GeneID" id="19894823"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01126"/>
    <dbReference type="eggNOG" id="KOG1668">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050172_0_2_1"/>
    <dbReference type="OMA" id="YRWYKHI"/>
    <dbReference type="OrthoDB" id="331763at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005853">
        <property type="term" value="C:eukaryotic translation elongation factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000001">
        <property type="entry name" value="Elongation factor 1-beta 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018940">
        <property type="entry name" value="EF-1_beta_acid_region_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049720">
        <property type="entry name" value="EF1B_bsu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001326">
        <property type="entry name" value="Transl_elong_EF1B_B/D_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595">
        <property type="entry name" value="EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595:SF21">
        <property type="entry name" value="ELONGATION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10587">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00825">
        <property type="entry name" value="EF1BD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange" evidence="6">
        <location>
            <begin position="113"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="199" mass="22739" checksum="85E6ABFBEFAFA682" modified="2013-05-29" version="1">MMTHNRSVYTPSQADVSLFFEIKQLPLADKYPNLSRWYTHICSYTHEFESLPGERGKSAASYLGHIFICESKKEEDDIDLFASDEDSEAERIREERLALYKEKKASKPKIIAKSIVTLDVKPWDDETDMTALEEGVRAIEMDGLVWGSGKLVLVGYGIRKLQITLVVEDEKVSIEELQERIAELEDYVQSSDVVAMQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7NU28</accession>
    <name>M7NU28_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01329</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873256.1">
        <property type="nucleotide sequence ID" value="XM_007875065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NU28"/>
    <dbReference type="STRING" id="1069680.M7NU28"/>
    <dbReference type="GeneID" id="19895026"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01329"/>
    <dbReference type="eggNOG" id="KOG0730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_12_2_1"/>
    <dbReference type="OMA" id="KPPTIHW"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19503">
        <property type="entry name" value="RecA-like_CDC48_NLV2_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19511">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000661">
        <property type="entry name" value="calmodulin-interacting protein 111 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000178">
        <property type="entry name" value="CDC48/VCP homolog, AAA superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF27">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="4">
        <location>
            <begin position="34"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="261"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="524"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR10626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="782" mass="88084" checksum="468E304413647A7C" modified="2013-05-29" version="1">MPKNSLNINSKMIRDTSSQLQCTPSYINKEALASLTVQQNPETKINVLNKVYLNSSQLKKAGLSTGDLVLVENEKPSMPYSFGIAWMHSGTGADEVKLSEDLRKKGKILLGQQVSVRKYPLPVLKAQVVGIESLNLESEDNMLNKMKDFLVKIRYVSIGSEYEYHYQGKTIIVKIKMVDNLNELTNRIKAMELSDKRVYQDVFLITKDTKVVLSWDINDNPSFKITFANIGGLKHQIELLRDYVELPLLKPECFEIFGISPPKGVLLYGPPGTGKTMLLRAIANETKAYVELVNGPSVIGKYLGETEANLCKIFENAKKNQPSIIFIDEIDAIAPKRGEDTVERRIVATLLTLMDGMNSSGQVVVVGATNKPNALDEALRRPGRFEKEIEIGVPNIDARLEILNLHFSKMPHDLDEDDIKRLAKRTHGYVGADLTSVCREASILAIKRGIDKNIPEKDFTISKYDVETALKNVRQSAMREIFLETPHVKWSDIGGQQIIKQKLREAIEWPLTHPETFTRLGISPPKGILLYGPPGCSKTLIAKAAATEAGINFFAIKGPEVFNKYVGESERAIREIFRKARLASPSMIFFDEIDALSINRGLGEETNDRVLSALLNELDGIENLINVTVLAATNRPDVIDNALLRPGRFDKIVYVGLPDLETRKDIFKIKFRTMNIANDVDIEYLSEKTDGCSGAEIAALCQDAGINAMYDNINAINIEKKHFDKALMNLVKHTTVEMIDFYKSFNHGHLKILRQKFYQKYIYSVYLYLGKRCFFNFNQRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NU41</accession>
    <name>M7NU41_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.216</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">tRNA 2,2-dimethylguanosine-26 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA(guanine-26,N(2)-N(2)) methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA(m(2,2)G26)dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_01337</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:43140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10359"/>
            <dbReference type="Rhea" id="RHEA-COMP:10360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
            <dbReference type="EC" id="2.1.1.216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="7"/>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873265.1">
        <property type="nucleotide sequence ID" value="XM_007875074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NU41"/>
    <dbReference type="STRING" id="1069680.M7NU41"/>
    <dbReference type="GeneID" id="19895034"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01337"/>
    <dbReference type="eggNOG" id="KOG1253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010862_0_0_1"/>
    <dbReference type="OMA" id="CAYSAYA"/>
    <dbReference type="OrthoDB" id="6349953at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140691">
        <property type="term" value="F:RNA folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160104">
        <property type="term" value="F:tRNA (guanine(26)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160103">
        <property type="term" value="F:tRNA (guanine(26)-N2/guanine(27)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002940">
        <property type="term" value="P:tRNA N2-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.70:FF:000001">
        <property type="entry name" value="tRNA (guanine(26)-N(2))-dimethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000051">
        <property type="entry name" value="tRNA (guanine(26)-N(2))-dimethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="entry name" value="N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00308">
        <property type="entry name" value="TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631:SF3">
        <property type="entry name" value="TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 12" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR10636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="402" mass="45414" checksum="389C2553ECFE81F1" modified="2013-05-29" version="1">MANDYAKSSIEMIKKNSIYNNVSEKIKLSFEDARFLMYKHVIQRKHLDVIDLDPYGTASPFIDAAVQSVSDGGLLCVTCTDLAVLAGGGYPEKCFSNYGSMPFRNSVFCHEQALRIVLHTISSSSARYGRYITPLLSIFADFYIRLFVKIETSPYNVKFLHNNIMMSYLCSGCYTFYNQPIGKTSPSKNLNTYKHFNSQGPIVSPNCEFCGFKLHISGPMWSGPLHDKEFVKNVLNILESESIDIYETLPRMKRMLSIIEDELVNPFYYSPAHLSKILHCQTPPLKDIASALINFGYLVSFTHASPGCIKTNASPKILWDIMKSWIKQCPVNKEHIHDGTAGKEILKSEPDICVNFLFNPNINKIFKRGLVKYQLNPTKNWGPKAKAKVGTRTNGNENENLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUD7</accession>
    <name>M7NUD7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PNEG_01059</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872971.1">
        <property type="nucleotide sequence ID" value="XM_007874780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUD7"/>
    <dbReference type="STRING" id="1069680.M7NUD7"/>
    <dbReference type="GeneID" id="19894757"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01059"/>
    <dbReference type="eggNOG" id="KOG0214">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_5_1_1"/>
    <dbReference type="OMA" id="CYDRNDS"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140727">
        <property type="term" value="P:siRNA-mediated pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15 23" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="19">
        <location>
            <begin position="37"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="213"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="476"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="575"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="22">
        <location>
            <begin position="674"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="16">
        <location>
            <begin position="750"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="1124"/>
            <end position="1215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EMR10912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1218" mass="138339" checksum="03B73A6A57B059B4" modified="2013-05-29" version="1">MTIKYNLEDPYAYNFVSEEITQEDQWTVISSFFDEKGLVSTQIDSFDEFIQNTMQELVDEDATLTLDQHAQHTGIEGDVTRRYEINFGQIFLSKPSMTEADGSTQLMFPQEARLRNLTYSSPLYVDIKKKVMIATDPSAPFGSDKEWIIEEDEQPSKVFIGKIPIMLRSTFCILNGLPESELYELNECPYDQGGYFIINGSEKVIIAQERSAANTVQVFKKPAPSAVSYVAEIRSAVEKSSKLMSNFQIKLMSKSIEKGAGQTIRACLPYIRNDIPIVIVFRALGVVPDRDIMEHICYDPNDHQMLEMLKPCIEEAFVIQEREVALDFIGKRGSAVGINREKRLRYAQDILQKELLPHITTTEGYETRKAFFLGYMIHRLLLCALERRDPDDRDHFGKKRLDLAGPLLANLFRMLFKKLTKDVYKYMQKCVETNREFNLTLAVKSNTITHGLRYSLATGNWGDQKKIMSARVGVSQVLNRYTFASTLSHLRRTNTPIGRDGKVAKPRQLHNTHWGLVCPAETPEGQACGLVKNLSLMSYVSVGSASAPIIEFLEEWGMENLEDYNPSATPNTTKVFVNGVWLGVHRDPYHLVETIKSLRRKLDISVEVSVVRDIREKELRIFTDAGRVCRPLFIVDNNPESNCRGQLMLKKEHVQKIIDNKNRTELDNESKFGWSSLVANGIVEYIDAEEEETIMIAMTPEDLEATRQIQAGYKIADEIDPARRVKPLVNPNTYLWTHCEIHPSMILGICASIIPFPDHNQSPRNTYQSAMGKQAIGVFLTNYQVRMDTMANILYYPQKPLATTRSMEYLRFRELPAGQNAIVAILCYSGYNQEDSVIMNQSSIDRGLFRSIFYRSYMDQEKKIGMQIMEEFEKPMRNNCLKLKHGTYDKIEDDGLIAPGTRVSGDDIIIGKTAPIPPNAEELGQRTKFHTKRDVSTPLRSTESGIIDQVMVSTNAEGLKFVKVRMRSTRIPQIGDKFASRHGQKGTIGITYRHEDMPFTSEGIVPDIIINPHAIPSRMTVAHLIECLLSKVSALSGYEGDATPFTDVTVEAISKMLRQHGYQSRGFEVMYNGHTGRKLVAQVFLGPTYYQRLKHMVDDKIHARARGPVQILTRQPVGGRSRDGGLRFGEMERDCMISHGASSFLKERLFDASDAYRLHICDICGLTAIANLKKNQFECRICHNKTNISQIHLPYSAKLLFQELMSMNIAPRLYTNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUJ2</accession>
    <name>M7NUJ2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00905</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HesB/IscA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872816.1">
        <property type="nucleotide sequence ID" value="XM_007874625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUJ2"/>
    <dbReference type="STRING" id="1069680.M7NUJ2"/>
    <dbReference type="GeneID" id="19894603"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00905"/>
    <dbReference type="eggNOG" id="KOG1119">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069054_5_3_1"/>
    <dbReference type="OMA" id="AMRISHK"/>
    <dbReference type="OrthoDB" id="1938621at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120510">
        <property type="term" value="C:mitochondrial [4Fe-4S] assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044572">
        <property type="term" value="P:[4Fe-4S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000006">
        <property type="entry name" value="Iron-sulfur cluster assembly 2 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011:SF1">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="6">
        <location>
            <begin position="35"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="148" mass="16868" checksum="804A907336D0B1E5" modified="2013-05-29" version="1">MTFIIHSLHKHNRFTFSYKSTSFSYISSISQDRFKIELTERAANQILNIVKKEKNPQLLLRVITESGGCHGYQNQFSLTEEIQSNDRVFEKDGARVIIDPISLNLINGSKIDYVSELIGESFKVIDNPLAKSICGCETSFDIEMSEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NUY0</accession>
    <name>M7NUY0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin-related protein 2/3 complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01067</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Cytoskeleton</location>
            <location evidence="7">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the WD repeat ARPC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872978.1">
        <property type="nucleotide sequence ID" value="XM_007874787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NUY0"/>
    <dbReference type="STRING" id="1069680.M7NUY0"/>
    <dbReference type="GeneID" id="19894764"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01067"/>
    <dbReference type="eggNOG" id="KOG1523">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034396_1_0_1"/>
    <dbReference type="OMA" id="YVWEPSP"/>
    <dbReference type="OrthoDB" id="406844at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000601">
        <property type="term" value="P:positive regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017383">
        <property type="entry name" value="ARPC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709:SF2">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038093">
        <property type="entry name" value="ARP2/3_su1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="52"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="331"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="366" mass="41039" checksum="D19C0A68580BA783" modified="2013-05-29" version="1">MANNVINILQLGSPINAHAFNGAKNQVALSLNKNSVEIYEDKGTGFDHKNTLIGHDKLVTSLDWAPRTNKIVTCSQDRNAYVWNLSQDGCWKPTLVLLRINRAATYVRWSPNEDKFAVASGAKIISVCYFEKQNDWWISKHIKKPIRSTVLSVDWHPANVLLASGSSDMKARVFSAYIKDIDQRPEPTVWGSRLPFNTVCGEFSSISGGWVYEAKFSPSGNALAFTTHSSSITIVYPTGNENPPVIFTVNISQLPYVTLVWINEFEIIFAGYSCRLASFQGNINGWKFVREIDDCHLKSPVNDSESHTFSTLKNSFRDMDLKGNVEDMTMPTVHQNTITQLTLYENKTSVFLSSSGVDGKLVIWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NV02</accession>
    <name>M7NV02_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_00728</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872629.1">
        <property type="nucleotide sequence ID" value="XM_007874438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NV02"/>
    <dbReference type="STRING" id="1069680.M7NV02"/>
    <dbReference type="GeneID" id="19894426"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00728"/>
    <dbReference type="eggNOG" id="KOG0670">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_5_5_1"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14135">
        <property type="entry name" value="STKc_PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000440">
        <property type="entry name" value="CMGC/DYRK/PRP4 protein kinase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase PRP4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044092">
        <property type="entry name" value="STKc_PRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF103">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PRP4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="372"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR11132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="687" mass="79951" checksum="34735A5A6275F377" modified="2013-05-29" version="1">MVDGSDDELSEGEIKETEEEQIASICKNEEFLGKQKVWFLRDSESYKYSRKPYISQNRDSISIAHGSKEKRHHDIDENSFKRGYEWEHQYVSKHHVKRSRKSKMSGMEKKNISEQKKRDSELDKEEKRFLKVDVEKDEKKKDGLWKKNGSPIFEQEVFEKSSIDEEALIEQRRKNREAILAKYRGQHSPFPDSQTKLDTLAFPSPETDNKVYESASFHPLMADMPDFQLTKDSSNISNVQDGEMAADYDPIVDGKLDEERQHFKNNNDISAAVYDETKQNENNTLTRYENRYDKVKINETNVNDELDMFADDDMFQEFKSVNEQTHELKNSSEAQDSVMLAARELDARLLDNWDDPEGYYHVILGELLDGRYAVRSNLGKGMFSGVVKAEDSKTRKMVAIKLIRNNETMRKAGMREIVFLKKLMEADPDDRKHIIRLERHFEHKGHLCLVFEMLSLNLREILKKFGNDVGINLKAVRAYAQQIFLGLSLLRKCNILHTDLKPDNILVNETRNYLKICDLGSASFDSDSNITPYLVSRFYRAPEIILGLSHDYSLDIWSIGCTLYELYTGKILFPGRTNNHMLRLMMECRGKFNHKIIRKGQFSSIHFDQHFNFISTEKDKVTGNDVSKIIAISKPVRDLRSRLLSNMSNEDPKLIKNFVDLLERCLDLDPEKRLTAYEALKHPFIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M7NV10</accession>
    <name>M7NV10_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major surface glycoprotein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_00565</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR10961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872459.1">
        <property type="nucleotide sequence ID" value="XM_007874268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NV10"/>
    <dbReference type="STRING" id="1069680.M7NV10"/>
    <dbReference type="GeneID" id="19894263"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00565"/>
    <dbReference type="eggNOG" id="KOG3544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010455_0_0_1"/>
    <dbReference type="OrthoDB" id="5400168at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021041">
        <property type="entry name" value="Maj_surf_glycoprot_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003330">
        <property type="entry name" value="MSG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02349">
        <property type="entry name" value="MSG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12373">
        <property type="entry name" value="Msg2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Major surface glycoprotein 2 C-terminal" evidence="4">
        <location>
            <begin position="899"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="842"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1026"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="786"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="859"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="884"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR10961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1074" mass="123275" checksum="E542D9140A62C88D" modified="2013-05-29" version="1">MDICICLRLKSYRNYFFSTINKIILIAILNLITLTYGNQSVDLSIKSSQINAVNPLSKGFIVKEEDIYAFILKRNYVDESKCKAKLEEYCKELKDIDPELNKVNSKVREICNNNDKRRKCKDLRLNIAKKALQLDSKMYKIAQKYMTYENCDKYLRECFFFERSAFNLLIDCYFLRYDCYVKKLSKLKSEIILQAIDDNIANYNDFKEKMKKICPIFIQQGNYLLFECLEIEKSFEKLNEYINYFCNSLNINFNDNELQEKCYEKLKNCYFLKNKCEKKCNELKVLCEKKNITYKPPEKDFNPINPEATLLKKIDLDGFYKKMRDEGIVGGNLETTLDDMLIYLSVGSSGLKENECKDVLKKNCDFLKYLSPKFKELCEDDKKQKCKDILEIKDRCKRHEITLYLNGFSPSFLQITGMRAQIFWNDLSTSFNDKECLKYTVECFFIRKTCRSNPTSGCINLQLACYKKQQERLFIKLIESQLVEKQYNLKSKDEKLKICQKIVMEKCVALANSDIKNFLKCLRPKEICLELEEIIFARSKDLEQALDQARDFPKEEDCIELKKDCEGIARDLGSNNLKCVTLKERCKYLEVTKELKYDFLKDKSDSLVNIQNCMKALKEKCDGLFKRGTNAFGVSCALPEETCKFMVSEVENHCNAFKNNIEKHDIVNKSKNGNETLVEEICILWDPYCDELMENCPDKLKKGDNGNEKGVCLQLKENCRPFFEKLKLEDELTHELKGSLGKDDECKKALGKHCSERKDSGNQKFNSFCNTDKDKDVEGKVCKKLVEKVKEKCLTLKNKLDKEKDELKKKKDEYEKVKQEAEKFAKEAKLLLLRLGKDVQGAESKVQDNSSPKSVLPSALPPAQPRPPTGSSRLPSGGIPAGLPTPGGSTPSGTTNTSNVILVRRTFVSGEVSEAEKKAFVATARALELYLELKEKCKGLQGDCGFRKDCPGCEAACKEIDKLCEGIEGLKVTPQHTVTLTTTKSINGGKVTEQCTFPQTTGIWTSTFTVTSTVTWTSMQKCKPTRCTSDSSKETQTQKEEEEEKEVKSNQGMKIRVPEMIKIMLLGVIVMGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7NV65</accession>
    <name>M7NV65_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">GTP-binding protein rhb1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_00620</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Lipid-anchor</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the small GTPase superfamily. Rheb family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872518.1">
        <property type="nucleotide sequence ID" value="XM_007874327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NV65"/>
    <dbReference type="STRING" id="1069680.M7NV65"/>
    <dbReference type="GeneID" id="19894318"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00620"/>
    <dbReference type="eggNOG" id="KOG0395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_9_8_1"/>
    <dbReference type="OMA" id="SARHNEN"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019003">
        <property type="term" value="F:GDP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905589">
        <property type="term" value="P:positive regulation of L-arginine import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04137">
        <property type="entry name" value="RheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000273">
        <property type="entry name" value="GTP-binding protein Rheb homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR11021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="190" mass="21243" checksum="62BB74955154A1EF" modified="2013-05-29" version="1">MPPPKSRKIAVMGSRSVGKSSLTVQFVEGHFGILFLLRNYYPTIENTFNKTIKFKGQEYATEIIDTAGQDEYSILSSNYSIGIHGFILVYSVASKSSFEMIKIIRDKILNHTGTEQVPIVIVGNKSDLHIQRQVTSEDGKNLALKWGCSWTEASARHNENVAKIFDFIILEIEKQINPSLSGENKGCEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVH1</accession>
    <name>M7NVH1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_00302</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872174.1">
        <property type="nucleotide sequence ID" value="XM_007873983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVH1"/>
    <dbReference type="STRING" id="1069680.M7NVH1"/>
    <dbReference type="GeneID" id="19894000"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00302"/>
    <dbReference type="eggNOG" id="KOG4163">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001882_4_1_1"/>
    <dbReference type="OMA" id="EVYWVTH"/>
    <dbReference type="OrthoDB" id="1350766at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00862">
        <property type="entry name" value="ProRS_anticodon_zinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.30:FF:000001">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000005">
        <property type="entry name" value="bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="entry name" value="YbaK/aminoacyl-tRNA synthetase-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="YbaK/ProRS associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="224"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR11272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="679" mass="77707" checksum="FAD03F817CB8B6DE" modified="2013-05-29" version="1">MNEKGILHGLSCLSINDRYIINHEEAPSEVLWKKNLKKQTIFDKYLLTRIRLSKTGIDEDKEFKLVFIVGLEDSKIEFSSIASVLKCKSLHMVPSELVFDFFGVKSEQVSLFCLRKENISKIHLVLDSRILVKEELLAFRLSSNKTVFITSDQLLKYLVDLDVKRTDIDLSLKQKANFQSKVSLSNKDGLQEGTLIGITVKKKDNFSEWYRQVLIKGEWFDSEIKKMGVEGCYFPMFVSSKVLEKEKDHIEGFAPEVAWITKAGNSNLEEPIAIRPTSETIMYSYYSKWIRSHRDLPLKLNQWNSVVRWEFKHPQPFLRTREFLWQEGHTVYLNRKESEKEVFEILDLYEKVYIDLLAVPVIKGIKSEKEKFAGAAFTATIEGYIPASGRAIQAATSHSLGQNFSKMFDICVENPDTKVTGEKSKIYVWQNSWGLSTRAIGIMIMTHGDDKGLVIPPKVSKIQVIVIPCGITVKTTNDEQKLIQDGVENIVQELKKAGIRVNSDSRTLYSPGWKFSHWEMMGVPLRLEYGLKDHKASQVIAVRRDTGIKFAVPLSTLLQTVSELLTTIQSDLYKKAKKMYDENIQIVYKWDDFVPSLNKKKVLLVPWCKISSCEEKIRQRSSNESNIELDEEETLLSMGAKSLCIPLEQPSGEYLLKGITRCVACENFATTFALFGRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVV8</accession>
    <name>M7NVV8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nascent polypeptide-associated complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00466</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the nascent polypeptide-associated complex (NAC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the NAC-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872348.1">
        <property type="nucleotide sequence ID" value="XM_007874157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVV8"/>
    <dbReference type="STRING" id="1069680.M7NVV8"/>
    <dbReference type="GeneID" id="19894164"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00466"/>
    <dbReference type="eggNOG" id="KOG2240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098726_3_0_1"/>
    <dbReference type="OMA" id="AGDTYME"/>
    <dbReference type="OrthoDB" id="8033832at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22055">
        <property type="entry name" value="NAC_BTF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000001">
        <property type="entry name" value="Transcription factor BTF3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039370">
        <property type="entry name" value="BTF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10351">
        <property type="entry name" value="TRANSCRIPTION FACTOR BTF3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NAC-A/B" evidence="5">
        <location>
            <begin position="32"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR11447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="148" mass="16208" checksum="C6F6A1B700CADB27" modified="2013-05-29" version="1">MDNSKLSKLQTNVRIGGKGTPRRKKKVVHRSSGDDKKLQSSLKKLNVQPVGGVTEANFFKTDGIVTHFSAPKVLASIPSNMFVISGLSEDKELTDLVPGILNQLGRDSLASLRKLTGNYTNLHKTKTGDPNEDDDYIPDLVEVFDAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M7NVX5</accession>
    <name>M7NVX5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872163.1">
        <property type="nucleotide sequence ID" value="XM_007873972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NVX5"/>
    <dbReference type="STRING" id="1069680.M7NVX5"/>
    <dbReference type="GeneID" id="19893989"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00291"/>
    <dbReference type="eggNOG" id="ENOG502RZK4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1152188_0_0_1"/>
    <dbReference type="OMA" id="AKQYPRC"/>
    <dbReference type="OrthoDB" id="244190at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15859">
        <property type="entry name" value="SNARE_SYN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="2">
        <location>
            <begin position="151"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR11261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="241" mass="28565" checksum="B081759400266D6C" modified="2013-05-29" version="1">MTSISNSKLFFLIESCLYSILEKNKLKSLNLEPSFEDDKIIYETMKLIKDEIHELEIKQKDLEENRNMSTEILKYREVFLIKLQDYYKKLEELLESGDPNGYELIIELIKEQREYKQKDELVETSSFNSLEFEKSIEKPKIENTQILKTQHQIIKEQEASLNNLYNSISLQKELTIQMESELELHDDLLEEMEVLIDRSQIKLDKSEKRLEGFTKGIKNNSGIFWIIMIFIVLIFLIIIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NW28</accession>
    <name>M7NW28_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872413.1">
        <property type="nucleotide sequence ID" value="XM_007874222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NW28"/>
    <dbReference type="STRING" id="1069680.M7NW28"/>
    <dbReference type="GeneID" id="19894223"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00525"/>
    <dbReference type="eggNOG" id="KOG1685">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026457_5_0_1"/>
    <dbReference type="OMA" id="PQRAYKN"/>
    <dbReference type="OrthoDB" id="10251727at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="265"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="36176" checksum="85FBC0835666F9DF" modified="2013-05-29" version="1">MGKEMELLNSKAKKACKVLLKHVQSIEKKKEKEKKQDILNLDKEDLRSSLPVWVILSTKTFITNSKKLKPSKIVLKHPIINRDSECCMIVKDPQRVYKDLVTSAKLNKRVTKVIGISKLRKKFRSYQQKRELRDSYDFFVADSRVISLLPKLLGKAFYEKKRQPIPIDLATKSTPEHLFKEIEKAYSSTYLHLSPGTCTSIKCGAICQTPEQIAENIQIITNTLAEKFVKNGWKGIRGFHIKTSESIALPIWLCENVFDADVDKVKEIDKIVNDKKRKANDLNEENLKLEENIDNVQSTQNMHTKKHRKTATKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M7NW94</accession>
    <name>M7NW94_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871867.1">
        <property type="nucleotide sequence ID" value="XM_007873676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NW94"/>
    <dbReference type="STRING" id="1069680.M7NW94"/>
    <dbReference type="GeneID" id="19893714"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00016"/>
    <dbReference type="HOGENOM" id="CLU_576351_0_0_1"/>
    <dbReference type="OMA" id="HEYTADI"/>
    <dbReference type="OrthoDB" id="5295250at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="56"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="474" mass="55985" checksum="144138FE104BAD8F" modified="2013-05-29" version="1">MCSKEDMPLVCSFKDIYHHASPHRRRLIIDTLFTESSPADLWYIHQKLINKKPYYFDILSHLPYELLEMIFKYLDVEDIIIFSMVCKRWNILVTCNSVSKMLITIYFNIQTIENANNNWYSLFQKYAKKYLRIKKGMLKSFNILYPYNKVISCSLYTRLQDNYLILYNHSITESSNKGITLYRLKPGISQKDAIYISTENYGGILNASLDSCILVSVNYFGVFYIWSLNTLELIDTFKLGSSDVAFMTCRDNNICISTFSKVLSVWNLKLKKFMFYKTLEQIDPNLPKKCNVIAMEFLKRNNELILCVENMSSNNEILYYQYRIYVLLSDCGRILRYGSLMNKNMPFKTNIINEDELIIFYQFNSDRYLKMDLKTMHIVTCLFHKNHIQELEYLIYPQNSFIIKHLKSIDNSSDNGLYVEKCDPETGLLLSKNKILGSENIIYNQPCLKNRDSLQGNNNWIVYNHQNKVFLWEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NW99</accession>
    <name>M7NW99_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2,3-diketo-5-methylthio-1-phosphopentane phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871872.1">
        <property type="nucleotide sequence ID" value="XM_007873681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NW99"/>
    <dbReference type="GeneID" id="19893719"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00021"/>
    <dbReference type="eggNOG" id="ENOG502QRU0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058495_1_0_1"/>
    <dbReference type="OMA" id="YIPFETF"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050849">
        <property type="entry name" value="HAD-like_hydrolase_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181:SF2">
        <property type="entry name" value="PHOSPHORIC MONOESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181">
        <property type="entry name" value="UPF0655 PROTEIN YCR015C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="31666" checksum="DB10ABB1B3CD6735" modified="2013-05-29" version="1">MNEMNESFLGNTDLCKNKPNLFVFSDFDGTIVIQDTGKILFDRYGYSPEKQEKLEEALHRGERTFRDISEELWGHLKLPLTEGIDIIMQELEIDPGFYNFYDFCLNFSIPFWIISSGLHPLLKAALSKFLGVEMAEHIRIIANDVEVTSNGIWKPIWHDNTPFGHDKAASVKNCIKKYSNNDSKELSPLIIFIGDGISDFSVAKNVDILFARKGFSLEKYCIKHAIPYISYETFTDVQREIANILYNHHKYIPLIEPSTLEPACSNFLQASEAPTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NX13</accession>
    <name>M7NX13_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Vta1/callose synthase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_00135</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871996.1">
        <property type="nucleotide sequence ID" value="XM_007873805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NX13"/>
    <dbReference type="STRING" id="1069680.M7NX13"/>
    <dbReference type="GeneID" id="19893833"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00135"/>
    <dbReference type="eggNOG" id="KOG0917">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030378_1_0_1"/>
    <dbReference type="OMA" id="NECICND"/>
    <dbReference type="OrthoDB" id="391137at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041212">
        <property type="entry name" value="Vta1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18097">
        <property type="entry name" value="Vta1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vta1/callose synthase N-terminal" evidence="9">
        <location>
            <begin position="11"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Vta1 C-terminal" evidence="10">
        <location>
            <begin position="251"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR11701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="33730" checksum="B175E734DFF4989E" modified="2013-05-29" version="1">MEKPPVELKFIYPFVRRGEEMKKVDKVVFYYCYFWAVKRGLELQPKTKKSEIYLEKMMEKLESVKEDPMYKSIIQDEISGKIYMEKFAEQILRNADEDIRMKRVSLQTSKKFLAAVNFFEVLKIWGELSPDILYKLKYSKICAVDIIKACKNCQDPNDILFREKSISKPEIPSNLIEKEKDSIINDSSFDNFLTFNFDLEKKDTSNNLLSSEIEINNDTFHKMTKSEHNQSTLPDTSYLSNIQVVEDKIEKIEKAQKHARWAISALNFEDINTAISQLKLSLDILESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7NXD7</accession>
    <name>M7NXD7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">H/ACA ribonucleoprotein complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_00255</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the GAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872126.1">
        <property type="nucleotide sequence ID" value="XM_007873935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NXD7"/>
    <dbReference type="STRING" id="1069680.M7NXD7"/>
    <dbReference type="GeneID" id="19893953"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00255"/>
    <dbReference type="eggNOG" id="KOG3262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1533196_0_0_1"/>
    <dbReference type="OMA" id="WIMARNF"/>
    <dbReference type="OrthoDB" id="2187159at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237:SF6">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237">
        <property type="entry name" value="NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="131"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR11831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="175" mass="20074" checksum="610928089E14FB74" modified="2013-05-29" version="1">MNKQYFQSHIQNKNKWRGYSNTSANTNNVEIGSFVHACEGEMLYASTHTKIPYFNAPIYLENNCLIGKIDEILGPINQVYFTVKPQEGIIATSFHTGDKVYIGSDKLLPLERFLSLPKSTILKKKHGMFQTGNQAKGNRSHQKFNKKDRPSISGRKNFASFKKPKTSQRNFKRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7P2H4</accession>
    <name>M7P2H4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial DNA replication protein YHM2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_03520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875612.1">
        <property type="nucleotide sequence ID" value="XM_007877421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P2H4"/>
    <dbReference type="STRING" id="1069680.M7P2H4"/>
    <dbReference type="GeneID" id="19897207"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03520"/>
    <dbReference type="eggNOG" id="KOG0756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052717_0_0_1"/>
    <dbReference type="OMA" id="VMGPCTY"/>
    <dbReference type="OrthoDB" id="10253709at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180056">
        <property type="term" value="F:citrate:2-oxoglutarate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000053">
        <property type="entry name" value="Mitochondrial DNA replication protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000085">
        <property type="entry name" value="Tricarboxylate carrier, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053017">
        <property type="entry name" value="Mito_Cit/Oxoglu_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982">
        <property type="entry name" value="CITRATE/OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982:SF1">
        <property type="entry name" value="CITRATE_OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="230"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="36591" checksum="6E94AB018C2C0CEB" modified="2013-05-29" version="1">MLPFFPEKNAYSLNFFDKNKPYMNSEQNNKPAKKSVSYSNIIIGSILNLFEVSTLGQPFEVIKTHMAANRKDSIATSFRKIWNRGHILGFYQGLIPWAYIEASTKGAVLLFTASEVEYHAQTLGADSFVAGMMGGMCGGIAQAYITVGFCTFMKTVEITRNKYIKEGIKMPSTYKIFIDKYRKEGIRGINRGANAVALRQMTNWGSRIGFTRLIESKIKMIKNKDNSEQLSLIEKVICSSIAGGLSCWNQPIEVIRIEMQSAKRDPNRPLKLNVISTFKYIYKENGIRGLYRGVSPRICLGVWQTITMVALGDIAKQYMKKFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3P2</accession>
    <name>M7P3P2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_03298</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875373.1">
        <property type="nucleotide sequence ID" value="XM_007877182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P3P2"/>
    <dbReference type="STRING" id="1069680.M7P3P2"/>
    <dbReference type="GeneID" id="19896985"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03298"/>
    <dbReference type="eggNOG" id="KOG3234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_7_1_1"/>
    <dbReference type="OMA" id="EQHPSMR"/>
    <dbReference type="OrthoDB" id="10264728at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000065">
        <property type="entry name" value="N-terminal acetyltransferase complex ARD1 subunit homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051646">
        <property type="entry name" value="NatB_acetyltransferase_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="183" mass="21410" checksum="8E8D794B6EA64CCE" modified="2013-05-29" version="1">MSELRRFKATDIFSFNNINLDILTETYNISFYLSYLATWPNLFLVQETSLFEGKTKLMGYVMGKTEGIKKQWHGHITALSVASEYRRLGVARDLIKLLENISENMYNGYFVDLFVRHSNLAAISMYKSLGYSVFRRVIKYYNGSKGDDEDALDMRKPLSRDKFRESIRENGDKIFVLPEDIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7P3Q3</accession>
    <name>M7P3Q3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_03311</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875387.1">
        <property type="nucleotide sequence ID" value="XM_007877196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P3Q3"/>
    <dbReference type="STRING" id="1069680.M7P3Q3"/>
    <dbReference type="GeneID" id="19896998"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03311"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014571_2_0_1"/>
    <dbReference type="OMA" id="MLVNHRK"/>
    <dbReference type="OrthoDB" id="271164at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000013">
        <property type="entry name" value="Putative Sorting nexin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000022">
        <property type="entry name" value="Sorting nexin 3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="11">
        <location>
            <begin position="156"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR08485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="530" mass="60347" checksum="529CDE4F6A503CA8" modified="2013-05-29" version="1">MDKTQENEKCRVGFSISPFDDEHANPFADAVSLGRKLSDELENIEKLRTSTYSEKSDQDVSSKPWFTPNKSQLNVSSFRSYSTCRSPKSCLQNVELDYDPLSYLDDTGSTNLNFSNDTTHISSLTVLNEKSPLIDKLKNIGLDEPLHTSSEQSNKVVFTVSVGDPRIVGDIASAHTVYKIFTCITSNASKPIEYIVNRRYKDFLWLYNSLHSNNPGVIVPSPPEKQAVGRFQENFIEFRRHAFERMLRKIVAHPILQNDACVKMFLESDTFAADIKVKEKVPVHESKGFISSIGEVFTRGAFSGKYVEQDNWFNEQKQIFDLLDIQFKGMSKAIDTVVRQKKDLAQTTGDFGLALSNLSNIELDESLSLALISFSDLQIRIKEFYERQAQQDILILGSMVDEYIRLIGSAKHAFSLRQKAYLNWQAAESSLAKCRFEKTKGQGKFQQSSSESSINILDAEKRCDQLKCDFDNISNILKEEIERFEIGKIEDFRGSVETFLESVIEAQKELIELWETYLTELEKKTEVSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7P4C2</accession>
    <name>M7P4C2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cystathionine beta-synthase</fullName>
            <ecNumber evidence="4">4.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02873</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-homocysteine + L-serine = L,L-cystathionine + H2O</text>
            <dbReference type="Rhea" id="RHEA:10112"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874910.1">
        <property type="nucleotide sequence ID" value="XM_007876719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P4C2"/>
    <dbReference type="STRING" id="1069680.M7P4C2"/>
    <dbReference type="GeneID" id="19896560"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02873"/>
    <dbReference type="eggNOG" id="KOG1252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021018_0_0_1"/>
    <dbReference type="OrthoDB" id="728at2759"/>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007089">
        <property type="term" value="P:traversing start control point of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000003">
        <property type="entry name" value="Cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000118">
        <property type="entry name" value="Related to CYS4-cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005857">
        <property type="entry name" value="Cysta_beta_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01137">
        <property type="entry name" value="cysta_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="10">
        <location>
            <begin position="7"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR08695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="491" mass="54065" checksum="3BA41BC55DB81024" modified="2013-05-29" version="1">MNFSQSILQHIGQTPLIRLNHIPGEELLECDILAKCEFFNAGGSIKDRIAKMMIEQAERDGKLVPGSTLIEPTSGNTGIGLSLIAAIKGYRMIITLPEKMSQEKIAILKALGAEVVLTPSDVPWDSPESHIGMAKRLNKEIPGSVILDQYGNSNNPKAHELYTATEILAQTAGKIDMVVAGAGTGGTISGLARTLKKYNKNIEIVGVDPVGSILALPESLNTEVGMYHIEGIGYDFIPDVLDRSLVDRWIKISDKESFLMARRLIAREGLLCGGSSGAAMAAAVLAAKKLGKGKTCVVIFPDSVRNYISKFLDDRWMFDYSFLENPKKLTLDTLTLKSMNLKSLRPIDTSFTCLSLLKIMRNNSLEVFPIVDLSKKLVGLASIRGILSSVARSLSSFHDSIATVMSCFQKQLENPISIEQWFSLKSSSCFVSPKERFVVITLDTPVLMLMDFLNSYRYAIIVTPLSDTCFFTPKHVVTRTDLLDFIYRNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7P539</accession>
    <name>M7P539_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar pre-ribosomal-associated protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02755</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874786.1">
        <property type="nucleotide sequence ID" value="XM_007876595.2"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7P539"/>
    <dbReference type="GeneID" id="19896446"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02755"/>
    <dbReference type="eggNOG" id="KOG1791">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_235486_0_0_1"/>
    <dbReference type="OMA" id="VVWVWQS"/>
    <dbReference type="OrthoDB" id="72892at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059018">
        <property type="entry name" value="HEAT_URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039844">
        <property type="entry name" value="URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032436">
        <property type="entry name" value="URB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021714">
        <property type="entry name" value="URB1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500:SF0">
        <property type="entry name" value="NUCLEOLAR PRE-RIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500">
        <property type="entry name" value="NUCLEOLAR PRERIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26140">
        <property type="entry name" value="HEAT_URB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16201">
        <property type="entry name" value="NopRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11707">
        <property type="entry name" value="Npa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 N-terminal" evidence="2">
        <location>
            <begin position="63"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 central HEAT repeat" evidence="4">
        <location>
            <begin position="571"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 C-terminal" evidence="3">
        <location>
            <begin position="1523"/>
            <end position="1712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1758" mass="207113" checksum="DE66EB6273519267" modified="2013-05-29" version="1">MSNNITVDDLRNLINAKIYSNRSLVLIGLKKILDFFMDCEIRFYENLGSSSVLLSYFNTEVPCKEIFELWMYFHQNNDFPIVSLILEILIFVIRIIGLLGSYTTGNKIIKRILDFHIKSIYRNLSSNIDILVIGTLRLLIEMSCFNLGSFVLEIFKSFDFSHKVISKIMKNFSKVSINTSSRINARFLAFETPRTFMIRFIFCFLEFGPISLKLELFGYKNIFYDIFSGLVKDDLSFMQKVLDIILQFVIFEKGIPRSIKMSIFNENVLNELIALYSETDDGISRSMAIHNFLILLCTKHGMGICFECNGWYPKLETDFKKNKSLLIYNKNLSSFIFKLKITQDILQQELFLKICQACPELIAYCAPQFSLNIRFEPHLTISWLSISSVYQSLVLLPIPLMTFSSISSELILTTILENIIPSALTKVSLSSGLKYNSDLVVFFTANLILSSINKYRQIMTILDKKNDFNMKTFEWKKNRLLLRKMFLKRLPDIRVIFFVFKSVWGKSSNLLKFSVIKLFVYYMETFPEIIFFGKYDYSSILIKGFSEISEEASYGSLILYYLFRISYRFLPISKWWNKNQEFSETIFTTLVKFYLSSRNNEFRNEYKNLISSLLISSNAFSIALRMDSAELILKTLDDVKCFTSRVNIIVDFLGDSLMLYMNSPYKYMDYLVSFIFDYKLEINGRFPSLVLIVLIEQWDYFFKYSMSSDDDKFLIASWLSRVLGFFTLNEDIWEISKKISWKLTKSMEERSFEIACIFNETKLYTEFLEKSFLTGVCSKGSSFCLVTKKFQNISFVNYKYSCVSLSDNFILIDFILHGGISQLYIHFDNIIHYIRYKYINVCLLDVIVLKMMIYVLFFDNREIIYDFNDVILKYFKIIRSIGDVLRDTKDYDRFREIIIEKNRWLDNYLNFGSNFSSFKIRIFSKEFIYLVIDFIEPLDSCLLFEIMNKTYENFIEVLTDDSIRILSLSSDEWNEIFLLLEPYWSKDRFSEIWAEVVKRYIQQIHAFGDTRSDILDFFTLVFGRFFTVNNIEIVTISDFVLILNTGLKNGYSLNHIFELLIAKIFSLPDDSIFTFYEFIGNVFFLIFQNTENIFFSDLVSKICSKSSVFLEIMTEKVCEIVKKYENISTFSPFFFPNLLCFINAYILWKDYSLQKKKLITDKLNHHFVFLLQFIKDDLLNGFLDQNEKGFILFQILYQSIKLNLLFEDGKNILDKLCIGYNNIILSKRSVEMIELVAYRYGNEIVEKYIGIWFNNIIKLLIEYFSDDIKLSDDCLGFMESFANYLKSSGKMLSKYVSQSLLILLIKFGLKNHILLYNVVKFIYYVVKEFKHNIEDSTLFVSLILSSSSNWNDINTNSAIFFEHRLIIVQLLHYLICNLSTHISLYIIESIYNVYTGTTNAVDVILLDILQKYEEFVRHNFFNKKIILNIQSETKKNIPLEISFDTDDITVFLSSEILKKSIYSFPIMKESLLDFSQIYKDDLWLYCDVIENVYDFSFFLPLVLAYLISNEHILIKFLIDSNILGYVLISLSSDDRTIRKMALTVLSMFENKIICFSEKNQILMFFQLLKSSISLSGMELEPIPYVVSLFMALSIQIIINPSHFLFDEVCRFYLQRSKLDFHDIPIFFSLWNSSSDYYKQSNWLMSFLSSGLRTLSDYNIYKKRHIFELLCCLFSSEIVTNDIRFKIIKLFWFASNIYEVNVSLVRDYGILSWIDQQIAICKDGTLKIMLERLFLRFHHSRLSNLYKYKLNLSREKKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7P548</accession>
    <name>M7P548_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02771</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874801.1">
        <property type="nucleotide sequence ID" value="XM_007876610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P548"/>
    <dbReference type="STRING" id="1069680.M7P548"/>
    <dbReference type="GeneID" id="19896460"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02771"/>
    <dbReference type="eggNOG" id="KOG4727">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067237_2_0_1"/>
    <dbReference type="OMA" id="VDHRRKW"/>
    <dbReference type="OrthoDB" id="30343at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040107">
        <property type="entry name" value="Snu23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR08995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="194" mass="23130" checksum="511ECFBE41103C43" modified="2013-05-29" version="1">MVSKGIYENSTEPNFRRTWDLAEYAQKAADREEREKKEARIRWEKKHGKFKREATPPDVKIVEARDKLNLEENLNKTILVPYGASTGRQGKGVGYYCEACNETYKDSNSWIDHLNSKQHLRATNQTLRQKRVTLEDVRKRLAWLRKKTVDEKKHSEFSLSQRISEKQAIEEEERKERKEKKKMRRKEKVSHVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7P5B2</accession>
    <name>M7P5B2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major surface glycoprotein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09070.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874876.2">
        <property type="nucleotide sequence ID" value="XM_007876685.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P5B2"/>
    <dbReference type="STRING" id="1069680.M7P5B2"/>
    <dbReference type="GeneID" id="19896529"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02840"/>
    <dbReference type="HOGENOM" id="CLU_010455_0_0_1"/>
    <dbReference type="OrthoDB" id="5477726at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021041">
        <property type="entry name" value="Maj_surf_glycoprot_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003330">
        <property type="entry name" value="MSG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13361">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13361:SF1">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02349">
        <property type="entry name" value="MSG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12373">
        <property type="entry name" value="Msg2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Major surface glycoprotein 2 C-terminal" evidence="3">
        <location>
            <begin position="924"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="804"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1089"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="758"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="826"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="878"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1097"/>
            <end position="1117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR09070.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1140" mass="127499" checksum="43647A7490164EBE" modified="2016-03-16" version="2">MLLRDKRWVEEVAQKEAAMAQPVKRQAAGQAAGNDEIKEEQVLGLIVKSGYNNDNKCKADLKQYCEELKKIDGKLESVDVKVKGLCENIDKKCGDLKDKVKTELDAFKTELEKELNNLTDEKCRKYEEKCLLLEEADPSNLEEKCVKLRDRCYGRRRQGVTKEILFRALEGKVNDTDECKKRMKEICQGLSEYSDELIFSCFNSDKTCNGLKGSHQDSCKSLETELKDNELMEKCQEYLEKCYFYGSSCKDTKCDKVKNKCKGKGIEYEGPKLDFSPVKEKPRFPEKIEVENLYKKEEAKGIIVGKPKYKTLRDLALLLIKERNGKDEGEKCKKALEDCESFKHLDYGLEELCGDKDKEDRCKELVEVEDRCTNFKLELYLKGLSTEFEKDKESDYFSWGQVSKLVSREDCIKFESECFHLEGVCTNKIGKACENVRVACYKKGQDRVLNRYFQEGLKGLIGDLELVTENLEKCQKSVVGNYTKLKEDRRYFTKCHLPTKLCYELLDDVILQSEELEVVLNLRRDFPRKEDCVELKKKCKDLESDSYLNHEKCDTLNRRCEYLKVTEELRKRLLKRGDDALRTQGNCTAVLKKECEELSRRGKEDFSVSCALREETCSFMVEQTENECLFLKNNMDIGKIIEKIENGKRNETLVEELCTLFDPYCHQYIENCPDRLKKTNNAGRKGVCLELEEKCKPFFEKLKLENELTHKLKGSLSDETKCKETLGKHCTEWKKEGNQTLNSLCEDAKKEELCKKLVKKVKEKCPTLKNKLDNEKDELEKKKDEYEKVKQESEKFAKEAKLVLSRPEQNGQGGGSKAQDGSVPKPVGPPVQPPAPAQPTPGGVPVPAPTLAPPAQPTSGGAPLPVPPAAPGGTPGGAPVPVPPPAPGTPPAGPAGPSGPSGGTPAGPPAPGGSTPSGTTNTSNVILVRRTFVSGEVSEPEKKAFVATARALELYLELKEKCKGLQGDCGFRKDCPGCEAACKEIDKLCEGIEGLKVTPHHTVISTATQTTTTTATTTTTTTTTTTTTTTTTTTATTTESVDGGKVTEECTLVQTTDTWVTSTSLHTSTLTSTSTVTSTVTLTSMRKCKPTRCTSDSSKETETQKEEEKEEEVKPNEGMKIRVPEMIKIMLLGVIVMGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M7P5H5</accession>
    <name>M7P5H5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Shugoshin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02478</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shugoshin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874487.1">
        <property type="nucleotide sequence ID" value="XM_007876296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P5H5"/>
    <dbReference type="STRING" id="1069680.M7P5H5"/>
    <dbReference type="GeneID" id="19896171"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02478"/>
    <dbReference type="HOGENOM" id="CLU_522869_0_0_1"/>
    <dbReference type="OrthoDB" id="5394106at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011515">
        <property type="entry name" value="Shugoshin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07557">
        <property type="entry name" value="Shugoshin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shugoshin C-terminal" evidence="5">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="186"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="521" mass="60114" checksum="7142D0DE9A76137E" modified="2013-05-29" version="1">MLQSVKVRQLEMETGRLLQENFELRASLISLQEQNEKEKKKAHLERLELLKRALEDKLLEITDIVQNMLPESSIESLPIENDKREKKLKKIDNSIISINSLQELYLSEKSKKVLEEKKEEKSIKKNLIRFSNDKQINTNYINDSTQISDKNNDISKELSTEAEDCSFIYIEKKAFDFANKNIESKQKEKRVSKSKEKPQVSEKNDSPDDFIYTRTKTNTEDKKQTHWILNTLQCEKTDDINVEKENIINFELSCLKEKNKNNNSTEKSIRSNKTCIRKALESKPSIANKNVETVNDWKNSQEIKTKTPAFLHVTKIMESSSPEKRVGRAKKPVNYALPSLKTKMRRDDSIVEDNLNKNYSKKNISENQILNLIGGSQEKSTKQEQNINVSSLVTKCEKTPSVVIHKTALSTKCNLSVLSMDTQKNSKSNTQSVLKSPIKFSNKKTLDHDLSSIEELSNSISCMNKKETTNDDLKSESFEKDKRRRTVHELLKTKSSISHISEYKTIQYQSGTFTRRKSMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6E0</accession>
    <name>M7P6E0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02378</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874384.1">
        <property type="nucleotide sequence ID" value="XM_007876193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P6E0"/>
    <dbReference type="STRING" id="1069680.M7P6E0"/>
    <dbReference type="GeneID" id="19896071"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02378"/>
    <dbReference type="eggNOG" id="KOG2730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029658_3_1_1"/>
    <dbReference type="OMA" id="KALCIYY"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="258" mass="29565" checksum="E0186E33A6FC8FF9" modified="2013-05-29" version="1">MKKRNQRPEKLRQEEIDAGVSIKYDEHGESYIVIGQTIVRHSRSNFPSKLNKYWHQRRRLFKYFDRGIWLDEESWYSVTPEPLGRQIATHLSKIHDHNFVVVDGFCGAGGNAIQFALIDKIAVIAIDDDPIKLICAKHNARIYNVEHKIVWILADFFNISKKIKGDIIFLSPPWGGPDYQNSEVFNIEAMKPYPASLLFHTANCMVNNSNKIVMYLPRTSSLASITALVKYPHKVEAHYLKASGKTKAICCYFGPLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>M7P6T7</accession>
    <name>M7P6T7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U5 small nuclear ribonucleoprotein 200 kDa helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02184</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874167.1">
        <property type="nucleotide sequence ID" value="XM_007875976.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7P6T7"/>
    <dbReference type="GeneID" id="19895877"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02184"/>
    <dbReference type="eggNOG" id="KOG0952">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000335_2_0_1"/>
    <dbReference type="OMA" id="MCSATEF"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000198">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000002">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000231">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003287">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF13">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="283"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="512"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="1141"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="1349"/>
            <end position="1556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1933" mass="222816" checksum="0989FC36D148D5B3" modified="2013-05-29" version="1">MNSTNAFSNSLKEMKNYLNKIGEYNENYRNNLYFIKIKNFYGNDFKKYLSNLYLIIDSFKKESKNDINFQEHTINSIKKPLDLNKVKDYCESIEKKNICLYIEPLFVTIKNIILSTNNEFELQNELLNILGYNNLDFIILIIQNIQNLKNEVLHINNQANSWNNVIFSSRKDYRNASESNITRYDQDNLFFKDQSYENLESYPNIYGISNSRSSLSIFGTKFSLPLCSTRDIYPLYEEITVQPPNKAQKIDNKIIFIKEMNNLCSKSFQEYQTLNYIQSLIYPIAYETNENMLICAPTGAGKTDIAILAIMRVISQFSDPSPYKEPKSKNFKINKSEFKVIYISPMKALASEIVKKIKGRLSWLNIQVQELTGDIQLTKSEIISTQILVTTPEKWDIMTRKNVGDIGLTQKVKLMIFDEIHMLHDERGTVIETLIARTQRYIESSQTMIRIIGLSATLPNYIDVARFLGVNCYHGLFYFSDQFRSVPLEQHFLGVKGKPGSKISSTNMNLVTYEKVIQLVKNNHQVMVFVHTRKETAKTAKTLLNLALNDGYQDIFNPSNHTHYNFFKKDISKSKNKEMKELLEKGFGIHNAGMLRSDRNIVEKYFSIGIIRILCCTATLAWGVNLPAYAVIIKGTQIYEPQKGIFVDLGILDVLQIFGRAGRPQYEDRGIGYIITSNDKLAHYVSSVTQQHPIESKFMEKLTDNLNAEISLGSVTNVEEAISWLSYTYFYIRMKKNPLIYGLTQEDIRDDPQIYKRRKELIISAAKKLYETQMIIFNKKSGFLSPKDLGRIASNYYISRENIENFNLTLKSNITEEEVFHILSKSSEFSQMKYRENENEELKQLLEKYCHYKIKETIDSTPGKVNILLQSYISKALIEDSALISDSNYIATNASRICRALFEIALSRNWESALTILSVCKSIERQIWSYEHPLSQFNLPTKILQKLEMHNNIGNMEDLKRLSKTELGMLIHHIRLGGIISNYINKFPLIKIDAKIFPITKKILRIQLNIQPNFIWDNTIHNLVELFWIWVEDSDSTEILHSLHLLLSKKKKEETLDFVILLPDIIPSQILIWGISDKWLKAETMTPISLNNIVFPDDSSSITELLDLQPLPISALNNHVLEEIYSKKFIFFNAIQTQIFHTLYHTNINVLIGAPTGSGKTIAAELSLWWAFKTKPSSKIIYIAPMKALVRERVKDWTTRFANPLKKKIIELTGDTSPDSKEIYEANIIITTPEKWDGISRNWKKRKYVQEICLIIIDEIHLLGDDRGPILEIIVSRMNYIATQNKSHIRIIGLSTAITNALDLADWLSIKEEGLYNFRHSVRPIPLKIYIDGFSGHKYCQRMASMNKSVFSAILDHSPDKPVLIFVSSRRQTRLTSQDLITYCGLEENPKRFLHMSDHKLNMILTQVKDESLKNALNFGIGLHHAGLTENDRKLSEELFINNKIQILIATSTLAWGINTPTHLVIVKGTEFFDAKTQGYKDMNLTDVLQMLGRAGRPQFDTAGIAKIFVQDTKKSFYKHFLHEGFPVESSLHKVLTDHISAEIVNETISSEQDAIDYLTWTYFFRRIHKNPTYYGLSDSSQNSINTYLSKIINTSINELIESNCIYRDENGTLKATVFGSIASYYYISHKTIRNLLSKIKIEINFKSCLKLLSEASEFDELSVRHNEDIINKEISQKLPFKSEEMALPLWDPHVKTFLLIQAHLKHFDLPIIDYITDTISILDQSVRILQAYIDISTELGYLETCLEFISLLQCIKHARWPELSELSILPGVNHENAMNLQQISQTKLEFLPKKSKNDLEKLGLLLKVPKEKMIEFINVAKTIPIVTIEISQKEKSFLNITLIKDSKPYHPNYILYSPKFPKPQKEGWYILCTSHTSNRIHVLKRLTMSKHTHGILNTNIIIPQTIYGEIVNIIVISDTFCIKKVHSITLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7P703</accession>
    <name>M7P703_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873831.1">
        <property type="nucleotide sequence ID" value="XM_007875640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P703"/>
    <dbReference type="STRING" id="1069680.M7P703"/>
    <dbReference type="GeneID" id="19895554"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01860"/>
    <dbReference type="eggNOG" id="ENOG502RZW2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1644430_0_0_1"/>
    <dbReference type="OrthoDB" id="5423111at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032126">
        <property type="term" value="C:eisosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052649">
        <property type="entry name" value="NCE102-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165:SF1">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="8"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="161" mass="18324" checksum="29ACC399F69BB21B" modified="2013-05-29" version="1">MAEKYIYIVIRILAIVIGLLILSLSVDINQQRRYKNQVQLPDMNFTLFTGLFSIITTVFEFVKASVSSFNRPIITLINDILNLIFTFSASIILSHITGFHSCANVDYVKNTPVFLKSKGICREFHALTFLSLILFFLYIILSIISAFFYGKIKGSNSRLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7P891</accession>
    <name>M7P891_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Breast carcinoma amplified sequence 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01845</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPF27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873817.1">
        <property type="nucleotide sequence ID" value="XM_007875626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P891"/>
    <dbReference type="STRING" id="1069680.M7P891"/>
    <dbReference type="GeneID" id="19895539"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01845"/>
    <dbReference type="eggNOG" id="KOG3096">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082523_4_0_1"/>
    <dbReference type="OMA" id="SAWQESI"/>
    <dbReference type="OrthoDB" id="205794at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008409">
        <property type="entry name" value="SPF27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296">
        <property type="entry name" value="BCAS2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SPF27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05700">
        <property type="entry name" value="BCAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="23970" checksum="405F27243A4CDAA2" modified="2013-05-29" version="1">MVNIYFHDSLPYYDGNLSKKERTEVDILIAEEVPVDQPLHPLVCKYTEWNPSSMLIKSELERIENGYKLDAIDLSRYTSFKEPVTSDKKLWIHAINKSLVASEFLKGRIENLRLLEEFGKNSWLLHVKQLEHYLQQLETHLLDLQDEISILNKERKKFQTGDMGLQLQRLENEFRHSIRRIFDVEVANFLLEKEIHNFQNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7P975</accession>
    <name>M7P975_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ERCC1-like central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01115</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERCC1/RAD10/SWI10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873030.1">
        <property type="nucleotide sequence ID" value="XM_007874839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P975"/>
    <dbReference type="STRING" id="1069680.M7P975"/>
    <dbReference type="GeneID" id="19894812"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01115"/>
    <dbReference type="eggNOG" id="KOG2841">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041616_3_0_1"/>
    <dbReference type="OMA" id="PHCVLVH"/>
    <dbReference type="OrthoDB" id="10262814at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070522">
        <property type="term" value="C:ERCC4-ERCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045002">
        <property type="term" value="P:double-strand break repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007534">
        <property type="term" value="P:gene conversion at mating-type locus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22325">
        <property type="entry name" value="ERCC1_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000001">
        <property type="entry name" value="DNA excision repair protein ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047260">
        <property type="entry name" value="ERCC1-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004579">
        <property type="entry name" value="ERCC1/RAD10/SWI10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00597">
        <property type="entry name" value="rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749:SF0">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749">
        <property type="entry name" value="EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03834">
        <property type="entry name" value="Rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC1-like central" evidence="7">
        <location>
            <begin position="34"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR10400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="233" mass="27299" checksum="6A2C03E36CD566FA" modified="2013-05-29" version="1">MTESREKSCILEDKKTTEDSLLNKTMRATGLHAILVNPRQKENPIIKHIRNVPLEYKDSMADYILGTTTCALFLSLRYHQLYPEYIYHRIQMLGKRYLLRILLILVDVDNHETPIRELTKTCVIYNFTMILSWSFLEAGRYLETYKSFEHASFNTIQGRNSDDYYSRLVECFSTMRNINRDDAFSIIGNFRSLKRAINADKEEIMMIGGWGEQKAGRFKKTVTLPFIVKDSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7P9X1</accession>
    <name>M7P9X1_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA pseudouridine(38-40) synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873300.1">
        <property type="nucleotide sequence ID" value="XM_007875109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7P9X1"/>
    <dbReference type="STRING" id="1069680.M7P9X1"/>
    <dbReference type="GeneID" id="19895067"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01370"/>
    <dbReference type="eggNOG" id="KOG2554">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014673_2_0_1"/>
    <dbReference type="OMA" id="DCKFPEM"/>
    <dbReference type="OrthoDB" id="25767at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02569">
        <property type="entry name" value="PseudoU_synth_ScPus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041707">
        <property type="entry name" value="Pus3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF5">
        <property type="entry name" value="TRNA PSEUDOURIDINE(38_39) SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="4">
        <location>
            <begin position="227"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR10670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="416" mass="48745" checksum="923A404686C9F20B" modified="2013-05-29" version="1">MLGKLQFVQNFTFMESKIHDYSTWTKDNLIKKIISLEHEILLKNKKKINIKQFIPKKSYLYNESSRPTKKSFSMSNYNQKYIAFKFAYLGWYYNGLVTQGNETHLPTVEETIFFALKKAKLIDQESNCNFSRCGRTDKSVSAIGQVIALNVRSNKSFEKDSEKKCCEIKYIDVLNRLLPKTIRILAWCSDLPSDFSARFSCQKRHYKYLFFKNSPGIHLDIEKMSKAAAYFVGEHDFRNFCKLDSSKSIKNFRRTIIKSEISKYNADEDDDPLYIFDLEGSAFLWHQVRCMISILFLVGQNLEEPEIVKTLLDISKTPKKPIYNIADGLPLILYDCHFENLNWNYGSNRNFIQNLYKSIYDLWHITKIQNSIIQLLLKNVQNNEVLDNNNTKKILIKDGTGINQSLTKYIQMENRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAH9</accession>
    <name>M7PAH9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_00996</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Binds to cdc4 and rlc1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872910.1">
        <property type="nucleotide sequence ID" value="XM_007874719.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7PAH9"/>
    <dbReference type="GeneID" id="19894694"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00996"/>
    <dbReference type="eggNOG" id="KOG0161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000192_5_3_1"/>
    <dbReference type="OMA" id="DVRFLHK"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120104">
        <property type="term" value="C:mitotic actomyosin contractile ring, proximal layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902404">
        <property type="term" value="P:mitotic actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01377">
        <property type="entry name" value="MYSc_class_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000001">
        <property type="entry name" value="Myosin heavy chain, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.270.10">
        <property type="entry name" value="Myosin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055914">
        <property type="entry name" value="DUF7491"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24319">
        <property type="entry name" value="DUF7491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50084">
        <property type="entry name" value="Myosin S1 fragment, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 9" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="13">
        <location>
            <begin position="46"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="12">
        <location>
            <begin position="99"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="9">
        <location>
            <begin position="659"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2280"/>
            <end position="2306"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="865"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1285"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1632"/>
            <end position="1712"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1743"/>
            <end position="1787"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1821"/>
            <end position="2066"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="2093"/>
            <end position="2275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="2282"/>
            <end position="2296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="2297"/>
            <end position="2306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="192"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR10850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2306" mass="269851" checksum="1BA0BFBDBF0379BE" modified="2013-05-29" version="1">MRKIEHQFNEESREFGIYSKDDSRESEKDMLIDSNLEDAAAQAEFSSKKWVWVKDVKKAFIKGWIVKEDGEYLQVRCIDDTDRVVKICEVDKVNPPKFDRVEDMAELTYLNEASVVNNLSLRYSSGLIYTYSGLFLVAVNPYKSLPIYTDKYINIYRNSKRSDTKPHIYSITDLAFHNMLEMRENQSILITGESGAGKTENTKKVIQYLAAVATSQSNEHQLKGLEQQILQANYILEAFGNAQTIRNNNSSRFGKFIRVGFNSKGKISGANIDWYLLEKSRVVQQNISERNYHVFYQLLTGASKELKRKLFLENSIEDFIFLNKSCKYIEGINDASDFYILKESFSVMGFSEDEQFSIFKLVASILHLGNLKVVSDRSDQAKLSNPEQAERLCHLFSIPVSEFTKALLRPKVKAGREWVTNARSSQQVIYSLEALAKSLYERMFGNLVEKINNAMDRNSTKMHFIGVLDIAGFEIFEVNSFEQLCINYTNEKLQQFFNHHMFVLEQEEYARENIDWKFIDFGHDLQPTIDLIEKANPIGILSCLDEECIIPKGTDKTFTEKLDYIWKDKSSKYRSSKFSGEAFILKHYAGEVEYFTTGWLDKNKDPLNENITQLLAHSSDKYISSLFLDFPEDIDLSPRKTRVKKGLFRTVGQRHKEQLASLIKQLKSTQAHFVRCILPNQFKKPFSFNSPLVLDQLRCNGVLEGIRIARTGYPNRLPFSEFRQRYELLTPCLPNDYIDGRKTAKLMLEKLDIDVSNYKIGLSKIFFKAGILAELEDRKDSCLQNILTQFQANSRGYIQRKIARKKLFRYNATTIIQKNLMIYLNLCQSPWWKLFFRMKPLLNATFIDNQLRKKNEEIEALSKIIKNEALTKKQLQLEKKIAEEQKLKFEEALQNERALALDKEEILKRTQEREAKLSEELAGAIEDLDRLEAQCDDLLAVKKKLDIQAEKWRVELQNGSVLISKLEEEKFGLIDQIKSLETTNAALSEKLLSSDDADKYKSHIKSLETSLEEKELKFLQSNKKFEKEILELEMSFKEKLKNYEYLQEQEKKYKKENEKLSIQLNKMSTNTISLEEYIQKKESEITNLRNDISKLVSERDQLKQELIASSIRNDASRSEVANLTKEIQELKIGKRKAENELIETQNMLHKKISQDTETNDIKNMLERQLLEVRTQLESAHEELRLERQSNIDYKEKSSNEIEKLKLDNQNLSEYKIEIEEKFQKLDNNFQKISEEYSELEKTKKSAMNEIIHLRKRALEAESAHSEIEKNQINLSRQLADITSKANIAMNELEDTNNSKAKLISETLLLKQKIEDLESEKIKLERSVKHSEQEIENLTTRIDTEQKNKLQVEKDLATSNSELSRLQTHIVDIVNEKLEDIKKEKNSIELEMKSWKSKYEENAVLMEELQKQKQRVTMELEDLEYELEREHQIAKSAEKMSTNLKIQLNETKTLLQTEKQQSIINHNNSLRFQKRFQEAHKEILEYRKKLISFEGVLKSEKNESSLDQKLNSNALELTKLLKQLDKVQNALISEEGKALIEKQYNEARKHWSNELSSQEAKYMESYQTLLNELSQPIIIPSHHSISSSPIFQKESNKNIFSASRIEGSKTEKLIKEYESRIHSNDGKENEEPLYLDKRKIQSLESEIESLEARLDMSEKQKKQLEMKLEFYQSSQTLKGGLDLKRLKRENDRLHELLNDNTDQLLALEKLQKNGIMTIRDFQSKSFEELEESFDSIAESRKSLLLEQKETLEELESTRKKLKELKKSQSNLQHEYNLLEEKLKAYELADESNTHLELVRELAEMQMRFEIESQRSIDLTENVTLYKNRAEEYFNKLETAEINVIKASRSEAFARSQLKDAEETISKMLRERKEMEEYFQSLQRQIQELEAKVEDNSIEILETNMSRQRIEQELEIYRGRRQKEIEDREYSLEQTRKKYQRELSSLSNELEIERENSIQVRNENRQLRETLEKLQLTWDAEMLNNSSWEREKNRLENSLQDLTKAYQEAIDSQQESQEHVISLFSQIRTMKISMDELEIEKNQLQKDKNALELKIKEISSQLDVAERNHGLSDKTNSIKDVSLLKAAIAEKDNIVNSALEKMKRAETLVHDVQKEIAIERENNVKLYEEKVLLEKEKMSLQIKLVDMETKLYSSSDINEEFLLKKIKELENQLRERDSMLNKENKTIRFTDRSIKDLQYQLSQRDKVKERLEDELDKSNEKIQKLKKIVDELQLSESTSQLALRRAERETRDEKEKSLRLEKELEKAKSRIESASIINRNSTIKSLSSLSSKSSPSRSDTNTRSTETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAL0</accession>
    <name>M7PAL0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01036</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the p23/wos2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872949.1">
        <property type="nucleotide sequence ID" value="XM_007874758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PAL0"/>
    <dbReference type="STRING" id="1069680.M7PAL0"/>
    <dbReference type="GeneID" id="19894734"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01036"/>
    <dbReference type="eggNOG" id="KOG3158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078883_0_1_1"/>
    <dbReference type="OMA" id="EEGPYWP"/>
    <dbReference type="OrthoDB" id="1564555at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06465">
        <property type="entry name" value="p23_hB-ind1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000013">
        <property type="entry name" value="Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045250">
        <property type="entry name" value="p23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932:SF1">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DAF-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="26"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="210" mass="24103" checksum="3C802FC332CB0D9D" modified="2013-05-29" version="1">MLIDEVKRTPSLKKIRVKKISGIMIQTTPEVKWAQRSSSSDPEKNVLYLTLVVPDVSDPVVNITETTLTLDALTKDGSIKYCLTLYFYKDVEPENYKLYRTDRCLALTIRKKEADEKYWPRLIQSSDKFGYIRTDFDKWVDEDEQNARPGDDFSSQFGGMGDFDFNKFSDGIGSENMPKLDDIDSDDDSDIEEDSIKDDSNEDVVSMDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M7PAY6</accession>
    <name>M7PAY6_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872537.1">
        <property type="nucleotide sequence ID" value="XM_007874346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PAY6"/>
    <dbReference type="STRING" id="1069680.M7PAY6"/>
    <dbReference type="GeneID" id="19894335"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00637"/>
    <dbReference type="HOGENOM" id="CLU_1661533_0_0_1"/>
    <dbReference type="OrthoDB" id="2530523at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="159" mass="18285" checksum="9C2D96F8BD07B1B4" modified="2013-05-29" version="1">MFGNNNLTPRCFDEINTDNKLIQTNHPVSYKSSKLNINLEDSRNINNNLPIDPSQTLSKSLELSRQRVSLLLEINTLLLQKCIELQNTENTKKEHSEASESTMTGCIQRLQTNLSYLAAVADKSYRSEENYLYKNPIIFSPPLNVYSLVEHYEKLKSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7PD65</accession>
    <name>M7PD65_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872120.1">
        <property type="nucleotide sequence ID" value="XM_007873929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PD65"/>
    <dbReference type="STRING" id="1069680.M7PD65"/>
    <dbReference type="GeneID" id="19893947"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00249"/>
    <dbReference type="eggNOG" id="KOG2865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_4_1"/>
    <dbReference type="OMA" id="PEDQFTN"/>
    <dbReference type="OrthoDB" id="275457at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05271">
        <property type="entry name" value="NDUFA9_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF11">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="60"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="361" mass="41656" checksum="53BCDE5E2AD3F6C1" modified="2013-05-29" version="1">MILQHCKSLRQKFIQTIHFRYFNYNSNKKLIHDIQISRTGKTLIKKGTEGRSSISGHIATIFGATGFLGRYLVNNLAKQGTTIIIPWRDQDSKRHLKVLGDLGQIVMMEFDLRDEISIKESVRHSNIVYNLIGRDYETKNFSYEDVHIHGAAKIAKACVEYNIDRLIHISTLNANIKSPSNFYKTKALGEETVRNIFPEVTIVRPSIMFGAEDRFLNYLASTKILLTTNNNRELIRPTYVKDVAHALELIMFDESTAGQIYELYGPQEYSVAEIITMITHITHCRQWHLNVSKSIFSIIASALNLLWWPTISPDQAQTQCIDYKITNNTKTYTHLGIKPQHLDKLAFKYLRMYQFSNNTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7PEA3</accession>
    <name>M7PEA3_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S16-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02949</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874994.1">
        <property type="nucleotide sequence ID" value="XM_007876803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PEA3"/>
    <dbReference type="STRING" id="1069680.M7PEA3"/>
    <dbReference type="GeneID" id="19896636"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02949"/>
    <dbReference type="eggNOG" id="KOG1753">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046483_4_0_1"/>
    <dbReference type="OMA" id="WPIEMAR"/>
    <dbReference type="OrthoDB" id="426865at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000007">
        <property type="entry name" value="40S ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001749">
        <property type="entry name" value="PRK00474.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR08779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="140" mass="15812" checksum="C8421FBFDA8FC104" modified="2013-05-29" version="1">MEFVQTFGRKKTATAVAHCKAGRGLFKINGSPIDLIKPEILRLKIYEPILIAGPDKFSNVDIRVRVSGGGRVSQIYAIRQAISKAIVAYYQKYVDEQSKIELKKTLVSYDRTLLVADPRRCEPKKFGGKGARSKYQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M7PEF7</accession>
    <name>M7PEF7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RhoGAP-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02631</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874650.1">
        <property type="nucleotide sequence ID" value="XM_007876459.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PEF7"/>
    <dbReference type="STRING" id="1069680.M7PEF7"/>
    <dbReference type="GeneID" id="19896322"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02631"/>
    <dbReference type="eggNOG" id="KOG1453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1704">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003874_0_0_1"/>
    <dbReference type="OMA" id="DKMWGLQ"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20824">
        <property type="entry name" value="C1_SpBZZ1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051854">
        <property type="entry name" value="Rho-type_GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46075">
        <property type="entry name" value="CHIMERIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46075:SF2">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 5A, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="26"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="7">
        <location>
            <begin position="883"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="8">
        <location>
            <begin position="961"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="426"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="770"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="354"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="775"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1153" mass="132031" checksum="C8B88C8C09D7702C" modified="2013-05-29" version="1">MVSLETNFIDVSGYQSLDQDSKILDPSCNGCNLIIEEGSVVAFGGYIWHVNCFRCMKCNAQVNHDSSLFFLYDRNPICEKCSCSSSISNKHSDDFAITTESESYHSEYFQCNICGKKIEEFVFAKTNQRIYCISCYNNKVTQNKKNERDIELSVPSLSFNKSLPSIPSTSTLSRLNSQTSMGSEVTVNDKPVEKPYIDLFLNIEQTELLNFNKVFSEFKNKEELNPKRNSKRHSFIWPPFAPLDFFLDISQTSINLETKHIPNTDEIKNNTTTISSDTSLSLSNHRSSIELPNFQESLKTKSVQEIAKHTDEEHIKGILKEFSKTKKYDKNISIKEEDIEEQKLISQKKKSISGTSLTENNRNHYSTSIGDVFQNTQSDSKQDMPSDFSFKSDFLHDLDIRIQTQNINSNSSSITNETNKFEDFSFESYNKNNPKNQDFVTLPKQDRNYDNQSETPSNHSNVTSTSPFSSNLESSKSFIKHSVLEETNINPLTFEISNISSKDSNAIYSKFHSFQKNTYDYQNNYVKDQNTQKHHFNQSYSKILNAIRHRRSASESKKKTSKYNIFSKSRVHEFQQLSPYINLNNLNETLNNYEDGSQETINLSQLKESKVKVINNESIMLDRDILKKKALLAELDAKCEITLRELKIFENEQLINQNRVLSRDDIFNGSIVSKLLISLTSLKNKFQSDIETLILQRNALYKKNTELLNIKNKITQEIHQLSFKKSELKDLNDKLTQKIQEQFRAHKNSTYISPQADIVFDNQNTKPLPPIITSVPKSNNDNFDLISPTESVSTPISEKTKLEYTESSDDNSSSKAHDKNDTRVLGSKISSWKKNSSLARNLVKGFNKIRSSESDTHNGCKDANLSTNLTNLTLKKSLSNNLRHTFSTYTFLRITRCDYCGNKLWGNEMRCLGCGIPCHIKCIGDITTNCNRSMEYLPYHENVSLYVSSSVNLHVPTLFGNDLTKQVQAENRNIPFIVTKCIDEVEKRGIFFEGIYRKSGSASQMRILIDAFNNNNIDNLSQSVFEDISVVTSVLKQYFRKLPNPLITYEIYIPFLEIIASDKTSKEKLISVKNVLNILPKAHYDCLEFLISHLCRIIEHSDKNLMPSKNLAVVFSPTLLRDEKGTRDIVDIQVKNIGIQYLLDNSKNIFQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7PF37</accession>
    <name>M7PF37_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosomal RNA-processing protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02425</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core complex (Exo-9) which may associate with the catalytic subunits RRP6 and DIS3 in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric base ring of RNase PH domain-containing subunits and a cap ring consisting of CSL4, RRP4 and RRP40.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874431.1">
        <property type="nucleotide sequence ID" value="XM_007876240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PF37"/>
    <dbReference type="STRING" id="1069680.M7PF37"/>
    <dbReference type="GeneID" id="19896118"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02425"/>
    <dbReference type="eggNOG" id="KOG1068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063514_0_1_1"/>
    <dbReference type="OMA" id="ECRINTH"/>
    <dbReference type="OrthoDB" id="437922at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030847">
        <property type="term" value="P:termination of RNA polymerase II transcription, exosome-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11370">
        <property type="entry name" value="RNase_PH_RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000004">
        <property type="entry name" value="Exosome complex component Rrp41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="9">
        <location>
            <begin position="20"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="10">
        <location>
            <begin position="153"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00063066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="239" mass="26802" checksum="899EFC8350A6560F" modified="2013-05-29" version="1">MTLEILSPEGFRIDGRRWNELRRFVAKVGFNTSADGSSYLEQGNTRVICTVHGPIEPIIRGKAFLDREHITVDISIAAFSTVERKKRTKLDKQIQEHVSCIQKVFEKTIQTGLHPRSEINIYIQVLTQDGGILQTCINAVSLALINASIPMYNYVSASTVGCTDTEPLLDLNNIEENSISWCTVAVLGASDNIIFLQTETRIHIEKFEHLISLALSGCQKIYKLMDNIIRNSDVVINHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7PF42</accession>
    <name>M7PF42_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase III subunit RPC6</fullName>
            <shortName evidence="6">RNA polymerase III subunit C6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874436.1">
        <property type="nucleotide sequence ID" value="XM_007876245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PF42"/>
    <dbReference type="STRING" id="1069680.M7PF42"/>
    <dbReference type="GeneID" id="19896123"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02430"/>
    <dbReference type="eggNOG" id="KOG3233">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033661_1_0_1"/>
    <dbReference type="OMA" id="VGTTKKC"/>
    <dbReference type="OrthoDB" id="613763at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000116">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007832">
        <property type="entry name" value="RNA_pol_Rpc34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016049">
        <property type="entry name" value="RNA_pol_Rpc34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12780">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED , 39KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05158">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028763">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR028763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="310" mass="35576" checksum="742F2254387F177B" modified="2013-05-29" version="1">MKTNEKKSPLLEMADYFELSSFAKHVYKCCLEFLPNCVTQDDIQNMLKNKSIEDLEKIINELLGKRLIDAFVQGNQLVYKAVQKDEAKKISAMDGDEAMVFNYIKDANNDGIWSRTIKIKTNLHTTVLNRALKSLESKQLIKAVKSVKNPTRKIFMIYDLVPSIELTGGPWFTDQEMDLEFIERLQGALYKYILSHSYPKSSDGLFPPSYSGYLTAHQIHSWLKNSGITEVDLELSDVVSLLNVLVYDRKIEYCLNGTAFKALRKPTHKSIYESTESACDFCSLNNTYSKEKNLSTNSCIYFRSWFDNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7PFG2</accession>
    <name>M7PFG2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02536</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874548.1">
        <property type="nucleotide sequence ID" value="XM_007876357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PFG2"/>
    <dbReference type="STRING" id="1069680.M7PFG2"/>
    <dbReference type="GeneID" id="19896228"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02536"/>
    <dbReference type="eggNOG" id="KOG0698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013173_1_1_1"/>
    <dbReference type="OMA" id="MCEESDG"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF837">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="64"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="338" mass="37929" checksum="7BDACFC2783D4A91" modified="2013-05-29" version="1">MVPSNIAPLGKYHSSSFSDFYEKQATLYNTLNLNIDEAEKEIDTTMTEAFQKTKNFPMQGNSFVIGSAKDKNKKCRKTMEDTHTYIYDFGGVTDQGYFAIFDGHAGYQAANFCKEQFHVILCNLLHNMPSSTIPDIFDATFTSVDNALANLPSKNSGCTAIAALIRWEERPFATISGFHEIRRTKLLYTANVGDARAVLCRGGKAHRLSYDHRSSDWHESQRIISSGGLIINNRVNGILAVTRALGDTYMKNFVISHPFTTETILIPNEDEFIILACDGLWDVCTDQQAVDICRNIYDPHIASRKLIDYAISQSSTDNITTIVIRLSKNDSEIKECLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7PFJ4</accession>
    <name>M7PFJ4_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PNEG_02565</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874579.1">
        <property type="nucleotide sequence ID" value="XM_007876388.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PFJ4"/>
    <dbReference type="STRING" id="1069680.M7PFJ4"/>
    <dbReference type="GeneID" id="19896257"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02565"/>
    <dbReference type="eggNOG" id="KOG1601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_594621_0_0_1"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF335">
        <property type="entry name" value="IRON-SENSING TRANSCRIPTIONAL REPRESSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="9">
        <location>
            <begin position="47"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="9">
        <location>
            <begin position="179"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMR09229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="463" mass="51726" checksum="3122763791294008" modified="2013-05-29" version="1">MSQIGIITNGNNKKEMVSLDGGSFSEKMLELDHENEINYKQNMTKKFSKGVYCSNCGVSYTPLWRRTSKGQYVCNACGLYSKAKNMSRPVRLKRVMVSSVSHRIRRKAAILLKVNGETCAGNGQCNGTGGAQGCDGCPVLNNKVSKTTKFISELENRGQESDSNFNLSMDNYGIHAVTCQNCGTTTTPLWRRDDSGNTICNACGLYYKLHSVHRPISMKKNSIKRRKRIHVQNKNETVDSNIENATSSLLELSNRSLVALSHVSSEVTRPLLKTLSDKTGKDEDRAKLNDQNFQAGSSFDSTLYLKNAVNSNENYKDNSIFSKESTNLVTKCHDDQYMSLLNSEYSKSLDPTMSSQTCPNPNKNTYRVPDIQSMLNSAPGNSGNVSFKVHTNMASIIELLTLEHPSGVEILIVPENVEKDTSLYKKYIENVKEDVKIHAERLKLMFSNAQRIIEECDKKLSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M7PGJ7</accession>
    <name>M7PGJ7_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874151.1">
        <property type="nucleotide sequence ID" value="XM_007875960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PGJ7"/>
    <dbReference type="GeneID" id="19895862"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02169"/>
    <dbReference type="HOGENOM" id="CLU_883153_0_0_1"/>
    <dbReference type="OrthoDB" id="5375151at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="315" mass="34919" checksum="356500B4A891BEF4" modified="2013-05-29" version="1">MPGRLNESSRMLTSTIETGASSIVASNRRRSSPTGWRPLDRPLSSSSFQDPLGLVSLFSRYSSGEVNETEMPSEVIEPETVEHGLSIEAPIETEAAAGSYTSLSSSLNLLRRRELRLREMRARVDGMAERLALMREARSVIRRSSPVRFFSSPSSLVSLSSSPVVLSSSATWPAGLVRRALRGELLASDAFLDANGDIWMDDRVPSESNDPSDTQHVTSNQDLFNDSEYPPPFVLSSYRIVDGVLFNLDGEQVGTTANLGSELRSCKELYDEMAMHSLFLRDCDNDGSLYLYSTIAHNESRQKRRKYSVDFCAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M7PHH7</accession>
    <name>M7PHH7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Helicase SWR1</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Helicase swr1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PNEG_01669</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SWR1 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873631.1">
        <property type="nucleotide sequence ID" value="XM_007875440.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7PHH7"/>
    <dbReference type="GeneID" id="19895363"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01669"/>
    <dbReference type="eggNOG" id="KOG0391">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_24_4_1"/>
    <dbReference type="OMA" id="CENNDKE"/>
    <dbReference type="OrthoDB" id="372624at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140849">
        <property type="term" value="F:ATP-dependent H2AZ histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031492">
        <property type="term" value="F:nucleosomal DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000005">
        <property type="entry name" value="Photoperiod-independent early flowering 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.850:FF:000009">
        <property type="entry name" value="SNF2 family helicase/ATPase (Swr1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF1">
        <property type="entry name" value="HELICASE SRCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00573">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSA" evidence="22">
        <location>
            <begin position="237"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="20">
        <location>
            <begin position="641"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="21">
        <location>
            <begin position="1177"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="427"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="526"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="547"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00074297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EMR09909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1461" mass="170796" checksum="E4271C193269EF0F" modified="2013-05-29" version="1">MSVTKKRKNDIEEEDKKKRCVDQSHIAEFHDSVITERQEKLKNIYYDQDDRIRQLYHLENFGSLIDYNPKVARQDKSERFIKFCESHNLISIISKDESCSFLPTEKSVNTKLNDEPKKINGEDLMNLKYESLSDDSDIGSKDKTSKSIDTYDPNRRLPTLKIKVKVPSPIITHPFHVLLMKKYESLDDYMSSFLILNNEEIPVNIAPSLAKIEAELLNKIEKAKLKGSLCKSSTLMIKKSIEPVRTLDHLDHLISHAIYFSKLVANERRTNISRARKISGMIMSYFRRLSGADEKEKKEAEKKIKQLAKRTSLEIKKKWKLIEKEVRRRRMEKLQEEQRKVGKLHLNKILEHSAQLLEAQKEGIKQVSDFQKQKTKNIKDFNINGCENNDKEHDSINKKYHHKISYIEDDESSLEKLKIKDSIISNQLKNNSNDSTDDECNKDQVDSDTDSSDTTGTISFIEEDIQHDDKSDTASCEKDFESFQETNEIDETDTTMDSEYDEDSEYDGNEEGPGLAFLYMDENIQTNSSPASTNSKEFNNYSSVDTENSEVEEYDNNEERTDDYITQKFNEDNIKEIDKKLINSEKPFSCLETEDSNTCDKNKINSESISDNKKSRQNIPIPFLLRGTLREYQYAGLEWLVGLYSNSVNGILADEMGLGKTIQTIALLSYLACEKGIWGPHLIVVPTSVMLNWEMEFSKFAPGFKVLTYYGNLNQRKNKRKGWYKPDTFHICITSYQLVIHDQQPFRRKKWHYLILDEAHNIKNFRSQRWKVLLNFNTERRLLLTGTPLQNNLVELWSLLYFLMPHGLSESMAIDFANLKDFQEWFSKPIDRMIENNNGTIDSDVQNQISKLHQLLRPYLLRRLKADVEKQMPKKYEHILYCRLSKRQRYLYDDFMSRAKTKETLASGNFLSIINCLMQLRKVCNHPDLFEIRPIVTSFAMSRSVVADFEIKDFLIRKRLLDEDPFYNLNLDFLNLIIVKHENKSHIMMNEIRLHCANNEILEYIESLKSTIDYSVPENYYNFKEYKNYVIQRTKISKLEKIQHFNYLNYMRCQSYSIYGSGLIQFCYISTNKILSMKEKSKPKDTMNLFWKTSNFLSDAVLDLKQRVDSMDTLLQKYSCVTPEVVATDLNLFLLRGISQSLLNLIQQKYTNILHPMQVRLSIAFPDKRLLQYDCGKLQRLVVLLRELQAKNHRALIFTQMTRVLDILEQFLNIHGYKYLRLDGATKVEQRQILTERFNNDSRIFVFILSTRSGGMGINLTGANTVIFYDSDWNPSMDRQCQDRCHRIGQTQDVHIYRFVSEYTIEENILLKANQKRMLDNLVIGEGYFTTDHLNNINWRDIIQANIKTDDIPQNERNLERILMATEDENDAIAAKIASCEMNTDAIDFAESTTIISNQDFTKNTSQTIQKSSITNTTQENYYVSSYTDLYNTNTHSTLEPRHIDEYMLDFITIEGCSDEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7PIQ0</accession>
    <name>M7PIQ0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873529.1">
        <property type="nucleotide sequence ID" value="XM_007875338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PIQ0"/>
    <dbReference type="STRING" id="1069680.M7PIQ0"/>
    <dbReference type="GeneID" id="19895270"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01575"/>
    <dbReference type="eggNOG" id="KOG0864">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067861_0_1_1"/>
    <dbReference type="OMA" id="NFKDSFM"/>
    <dbReference type="OrthoDB" id="2357150at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13179">
        <property type="entry name" value="RanBD_RanBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000312">
        <property type="entry name" value="Ran binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045256">
        <property type="entry name" value="RanBP1_RanBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF87">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE RANBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="74"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR10319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="213" mass="24579" checksum="00E092EFDF114055" modified="2013-05-29" version="1">MAQECPLTSTKTPKETPKMTEFSFSLSTFQNSTSTNSDLTKTTEETKEEKEDEGKATDGGKKEDQESPKQDDLHFEPIVQLNKVETKTNEEDETVTFKMRAKLFRFDKGEWKERGTGDVRFLTHNDSGKIRLVMRRDKTHKICANHYIDPNIKLISNVGSDRSWIWSVVADMSDGEPNAETLAIRFTNSENANLFKEKFIESQEKNKKFFTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJ34</accession>
    <name>M7PJ34_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01178</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873093.1">
        <property type="nucleotide sequence ID" value="XM_007874902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJ34"/>
    <dbReference type="STRING" id="1069680.M7PJ34"/>
    <dbReference type="GeneID" id="19894875"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01178"/>
    <dbReference type="eggNOG" id="KOG0908">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072377_0_0_1"/>
    <dbReference type="OMA" id="TAKDWVE"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000245">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="PITH" evidence="3">
        <location>
            <begin position="116"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="285" mass="32475" checksum="5D7E0B4757F8CDB8" modified="2013-05-29" version="1">MVVQEIQTSQDYDRIVYNTNNIVVVEFYASWCGPCKAIAPVFITLSEHPKFSDIIFIKVNVDHLRAVASKARISSMPTFVVFMNGTEAERISGANRQQLEFMIEKYSNMAVSVKGKESKDMKGFYPLDCFVDIRQLDCLNMDKKYPSKCIFEKEGYLQSDVDEQLLLYIPFKSTVRIYSLILECKNQKQAPSCLSLYINMTSLPSFDDVSDSGIKPTQRIEEISYDADGLVTIPLRFVKFQRVVSLVLFVEANQDDETSRIDKLTIVGETIEEAVNNGIVQKMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJD1</accession>
    <name>M7PJD1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ALIX V-shaped domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_01274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873198.1">
        <property type="nucleotide sequence ID" value="XM_007875007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJD1"/>
    <dbReference type="STRING" id="1069680.M7PJD1"/>
    <dbReference type="GeneID" id="19894971"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01274"/>
    <dbReference type="HOGENOM" id="CLU_1611472_0_0_1"/>
    <dbReference type="OrthoDB" id="2141925at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ALIX V-shaped" evidence="1">
        <location>
            <begin position="101"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="165" mass="19582" checksum="C914875EAFD2C8E6" modified="2013-05-29" version="1">MSYFNNIIKSLSMQTQENKELLKPLEKLSMTKAIPIQEIYIFSIKVYTKSIHKSVSLYSEQKAKLIRKELERCETGDLELDITLSHLKLPYSLKHERIIKVPEEIIGLSKSILDQKKGYKILSLFNSLLNLKERITIDLNKIEFIMNKEEQEHEKMRKKYLHKWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJR7</accession>
    <name>M7PJR7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SURP motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_00850</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872759.1">
        <property type="nucleotide sequence ID" value="XM_007874568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJR7"/>
    <dbReference type="STRING" id="1069680.M7PJR7"/>
    <dbReference type="GeneID" id="19894548"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00850"/>
    <dbReference type="eggNOG" id="KOG0007">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013259_3_1_1"/>
    <dbReference type="OMA" id="VKYQEQQ"/>
    <dbReference type="OrthoDB" id="447637at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000002">
        <property type="entry name" value="Splicing factor 3A subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000001">
        <property type="entry name" value="Splicing factor 3a, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045146">
        <property type="entry name" value="SF3A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022030">
        <property type="entry name" value="SF3A1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316">
        <property type="entry name" value="SPLICEOSOME ASSOCIATED PROTEIN 114/SWAP SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316:SF1">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12230">
        <property type="entry name" value="PRP21_like_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SURP motif" evidence="8">
        <location>
            <begin position="38"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="8">
        <location>
            <begin position="140"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="412"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="325"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="462" mass="53809" checksum="F94C8457BF2DF13E" modified="2013-05-29" version="1">MAQNNGVTSTPQTNGINPLIPPLAHMGMILPPLDIREIVEKTANYVSRNGIGFEEKIREKEKNNSKFCFLNPVDPYYKYYEFRLEECKKGKFLSPVVREDSSKTAKNASKNIPDKVSFLEPPKFYFSVSLPAISATDLDILKLTAQFVARNGREFQTTLSQRESRNFQFDFLRPNHSLFQYFTKLVKQYTRILIPPKNTNSILKRNIENKYQLLEVIRKRVAWQKYQEEQQKLKQEEEDREKIEYAQIDWHDFVIVETIEFTNADDQMDLPTPISLNVLQSATLEQKQMMAMYQDFNTPSEDISYNVSQPYSSQIEKEQPTHEEEGVEMDIEADSDEENEAIKERREYQAKVRHAQQQSKAGLPMKIRTNYVPKALKKIENTLICPQCNLAIPSNELEEHMRIEMLDPKWKEQKAKAESKSASSNLYQEGAASNLKRMTASMYDMQGSSMSKEEMERSKRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M7PJV2</accession>
    <name>M7PJV2_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000003">
        <property type="protein sequence ID" value="EMR10729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872789.1">
        <property type="nucleotide sequence ID" value="XM_007874598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PJV2"/>
    <dbReference type="STRING" id="1069680.M7PJV2"/>
    <dbReference type="GeneID" id="19894577"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00879"/>
    <dbReference type="eggNOG" id="ENOG502S84A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093522_3_1_1"/>
    <dbReference type="OrthoDB" id="4590138at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39474:SF1">
        <property type="entry name" value="FUNGAL SPECIFIC TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39474">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR10729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="92" mass="10600" checksum="5D7469B89C9EDB9C" modified="2013-05-29" version="1">MKEKAVNGIIEEDKKEPLMLMQGPSSGNHQSSLRLDNLGPLVVNRDGTLARIENWETLTEIEKNNIERVLVRRNRQRLEALRSMESEEVSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M7PKL0</accession>
    <name>M7PKL0_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR10994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872492.1">
        <property type="nucleotide sequence ID" value="XM_007874301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PKL0"/>
    <dbReference type="STRING" id="1069680.M7PKL0"/>
    <dbReference type="GeneID" id="19894294"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00596"/>
    <dbReference type="eggNOG" id="ENOG502QVP1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1090531_0_0_1"/>
    <dbReference type="OrthoDB" id="5556956at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027973">
        <property type="entry name" value="FSAF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053030">
        <property type="entry name" value="Ribosomal_biogenesis_FAF1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096:SF1">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15375">
        <property type="entry name" value="FSAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR10994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="267" mass="31434" checksum="30A07539234F108F" modified="2013-05-29" version="1">MNKTDEPKISKNFENIALKYLKKSFEDQFGSIHKFFEVKSGEKNLYEIPKLSEKVEDNVIKQEENPLEFPEVVNFLKKEKLRAVSNKNIEFHSFMSSKLPNFYEKRKSIKEVVKKQYLDYEQLKNDVALQRLLRESHLLKKGSNRSTFSLEPIGKQRHKIIENRIKLLGGKEIKEKVPFKIKLGMKLKAKIRSDIAKKKAKESGVVRALPAPKPKTKYKRNYGLNEIRIGKYHKGMITLSEKDIREAVSTPIFYKKNKKRENNRKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7PL09</accession>
    <name>M7PL09_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Actin-related protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872651.1">
        <property type="nucleotide sequence ID" value="XM_007874460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PL09"/>
    <dbReference type="STRING" id="1069680.M7PL09"/>
    <dbReference type="GeneID" id="19894448"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00750"/>
    <dbReference type="eggNOG" id="KOG0678">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027965_3_0_1"/>
    <dbReference type="OMA" id="GIHYPIR"/>
    <dbReference type="OrthoDB" id="421448at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10221">
        <property type="entry name" value="ASKHA_NBD_Arp3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000029">
        <property type="entry name" value="Actin-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000006">
        <property type="entry name" value="Actin-related protein 3 (ARP3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR11154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="48227" checksum="F34EFAF06CE3D872" modified="2013-05-29" version="1">MIPNLPVVIMDNGTGLTKIGLSGNDVPSYVFPTVITSSQTPGTGSGRSVSLSKSSFLGSSLSIGSSLNKRGAEDLDFYIGYEALEQANGLGYSLNYPIRHGIIETWDHMERFWQQSIFKYLKCDPEDHYFLLTEPPLNPPENREHTAEIMFESFNCAGLYIAVQAVLALAASWTSSKVQDRSLTGTVIDSGDGVTHVTPVVDGYVIGSALKHIPIAGRDITYFVQSLLRDRNESDSSLKTAERIKEEYSYVCSDIIKEFNKYDREPERFQKYFVETSSDKKVVVDVGYERFLGPEIFFHPEIATSDFLTPLPEVVDNVIQASPIDVRRGLYKNIVLSGGSAMFKDFGKRMQRDIRQIVDRRIRKGEERSGAKSGGLEVNVISHKKQKNAVFVGASLISQAPEFLSYCYTKKDYEEYGPGIVRRFAIFESFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7PLC7</accession>
    <name>M7PLC7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ER-derived vesicles protein ERV14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cornichon family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872156.1">
        <property type="nucleotide sequence ID" value="XM_007873965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PLC7"/>
    <dbReference type="STRING" id="1069680.M7PLC7"/>
    <dbReference type="GeneID" id="19893983"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00285"/>
    <dbReference type="eggNOG" id="KOG2729">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112942_0_0_1"/>
    <dbReference type="OMA" id="HKKECFI"/>
    <dbReference type="OrthoDB" id="434393at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003377">
        <property type="entry name" value="Cornichon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033466">
        <property type="entry name" value="Cornichon_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03311">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01398">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01340">
        <property type="entry name" value="CORNICHON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="16226" checksum="24A2E099EB529EB9" modified="2013-05-29" version="1">MSASAWLYLLTIITNSINLFIQVFFTIMYSDLECDYINPIDLCNKLNMYILPEAIIHAFSTLLFLFSRHWLPFLLNFPLLAYNINKIMTNQYTLDATEIFRTLSRHKKESFIKLAIYLLFFFFYLYSMISTLILNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7PLN2</accession>
    <name>M7PLN2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I and III subunit RPAC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00386</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872260.1">
        <property type="nucleotide sequence ID" value="XM_007874069.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PLN2"/>
    <dbReference type="STRING" id="1069680.M7PLN2"/>
    <dbReference type="GeneID" id="19894084"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00386"/>
    <dbReference type="eggNOG" id="KOG1521">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038421_0_1_1"/>
    <dbReference type="OMA" id="KKKCRAF"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07032">
        <property type="entry name" value="RNAP_I_II_AC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000003">
        <property type="entry name" value="Dna-directed rna polymerases i and iii subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033901">
        <property type="entry name" value="RNAPI/III_AC40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF13">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="7">
        <location>
            <begin position="60"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR11359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="349" mass="40163" checksum="CE678E2D479D993B" modified="2013-05-29" version="1">MSNKTFKKERREIGIKIDKITDVTNVDFPGHFYGEEYSWDIEEFKKKFRIENIVQLSAYNIEFDLIGIDSSIVNSFRRILIAEIPTIAVEYVFINNNTSIIQDEILAQRLGLIPIKANPDFFTWFIKPGENQEPKPTDYDTVVLSLKVSCTRNPKASKNETDPEKLYINSKVYSGDIQWQPAGRQIEIFKDDPIRAVHDKILIAKLRPGQEIDLTMHCVLGIGQDHAKYSPVSTSSYRLLPTIHILEPIYDDDAEKFACCFPEGVIDIVLDEQNRKIAKVANTRKDTVSRECLRYNEFKDKVKLGRVRDHFIFSIESTGIITSDELFLKSIYVLKEKCLLIKSVLQDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7PLV3</accession>
    <name>M7PLV3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">IMD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_00463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872345.1">
        <property type="nucleotide sequence ID" value="XM_007874154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PLV3"/>
    <dbReference type="STRING" id="1069680.M7PLV3"/>
    <dbReference type="GeneID" id="19894161"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00463"/>
    <dbReference type="eggNOG" id="ENOG502QTA6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028202_0_0_1"/>
    <dbReference type="OMA" id="CTADTLM"/>
    <dbReference type="OrthoDB" id="5594612at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037470">
        <property type="entry name" value="IVY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38407">
        <property type="entry name" value="PROTEIN IVY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38407:SF1">
        <property type="entry name" value="PROTEIN IVY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR11444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="45537" checksum="242A3B604FBA011A" modified="2013-05-29" version="1">MSSYLQQYPSSPTYSMSSTAQIAPTVASLCYSSAPPLPKTIITKNDISTSIEAYQELLYAAKIYRNSLVQLSKTASSFGTALEKCARCKGVGEEEMSGFMLAGGLQYLIANHQQILSETLYRRFEIPLMEELDTFRAITQERDDTYQRMMMEKNKKIQEREAEHLRVGRKKQRDLATFRQALVDLSKLADDLERLKSEHYNGALDTIHETWSRVLDHTALIVRAEVDIYEGIARKGWSGGGLEEIMARCEDPFNIGHGEISTTQGGHGEIFSILPSHSILTSPQSPIFNEGKLIGQYKSLTRTFSNEEEFDDYNDEDSKSIFSSDITKYKPIMDDETSRYEDKNTEIINLSSSNLLDINQKIQPIDIDILNNENGYYNSNGDELKNGFCTETNDNNPSDIHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7PLW7</accession>
    <name>M7PLW7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Spt20-like SEP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872360.1">
        <property type="nucleotide sequence ID" value="XM_007874169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PLW7"/>
    <dbReference type="STRING" id="1069680.M7PLW7"/>
    <dbReference type="GeneID" id="19894174"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00476"/>
    <dbReference type="eggNOG" id="ENOG502QS30">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_577656_0_0_1"/>
    <dbReference type="OMA" id="RMELIPP"/>
    <dbReference type="OrthoDB" id="1932706at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021950">
        <property type="entry name" value="Spt20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046468">
        <property type="entry name" value="Spt20-like_SEP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13526">
        <property type="entry name" value="TRANSCRIPTION FACTOR SPT20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13526:SF8">
        <property type="entry name" value="TRANSCRIPTION FACTOR SPT20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12090">
        <property type="entry name" value="Spt20_SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spt20-like SEP" evidence="1">
        <location>
            <begin position="44"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="401" mass="46758" checksum="6F7C25B2A968BD09" modified="2013-05-29" version="1">MAGKVNEKVGFRVDQIQKEVKKETQDKFLPLVKTSDELLERYKDESPSLILHMYPTHFRFEQQDGVFLYNSPMKIILEYIRMETIPPDCVEIFRDTRTRFYEGCLIVQIRDHRQSTNENSHSNENKDTKVVNEHVIPSKSPPRSFSTINVTEKVYYTVLKPSSETIWAEMCLFSESTGGKFNDEMAIEFESQILIATTPVLYLQPATNPMVMRRIFSELCELVPPIMKKRKQSPAEKIDEMKKAEEQLMLIMDEKQGKSFQPSFTRLAFIEKFRNKRSRTYRNFNFSRIYQRQNPQISVPNVLNNDPSMQKLHQRNTVVSSVANPASIKPMLKVQPTNIYTKEQQNMLRAQKTMLQIRTMQLKQSGMPIHQINEIIQQQAAQMGINIQEMSLPTKGIHVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7PMF6</accession>
    <name>M7PMF6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-mRNA processing factor 4 (PRP4)-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_00092</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007871949.1">
        <property type="nucleotide sequence ID" value="XM_007873758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7PMF6"/>
    <dbReference type="STRING" id="1069680.M7PMF6"/>
    <dbReference type="GeneID" id="19893790"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00092"/>
    <dbReference type="eggNOG" id="KOG0272">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_20_1"/>
    <dbReference type="OMA" id="LNEPICY"/>
    <dbReference type="OrthoDB" id="540662at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000411">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein Prp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846:SF0">
        <property type="entry name" value="PRE-MRNA PROCESSING FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="4">
        <location>
            <begin position="47"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="256"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="298"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="340"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="441"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR11654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="477" mass="53800" checksum="D6F36745E5409981" modified="2013-05-29" version="1">MLINNGIVVENLENEASNEYNRYSEKEQIILAEFERRQKIKSIYIPTDDGKVRAKLRELGKPITLFGEGPADRRDRLRELLSNFDGTVTFSEKETEEIEEEFYTSGTEELLICRRRIAEYSLNRARTRIARQKLESRIPLMKIINHRKAINKELKTYISLGSQICSDRPVGIARFSPNSQYIASGSWSGTCKLYSIPDLEEKHKFRYHVDKIGGISWNPGATIGGVSEEAINLITGGGEGDICLWNLKSETPISILKGHENRVCRVEFHPSGNYIGSASFDGTWRLWDITTTAELLRQEGHSREVYAISFQNDGALVCSGGLDAVGRVWDLRTGRTIMNLDGHIKPIQSLDFSPNGYQIASGSADDSIKIWDVRKIKCISTIPAHKNLVSDVRFFKTAHEEVLIQSKELIPTTSGIYLVSSGYDGRVNIWSSDDWVLIKSLIGHPDKVMSVDISKDNHWIISAGWDRTIKLWGSETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZX07</accession>
    <name>A0A0W4ZX07_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_04290</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="KTW32903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613375.1">
        <property type="nucleotide sequence ID" value="XM_019757809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZX07"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZX07"/>
    <dbReference type="GeneID" id="19896412"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04290"/>
    <dbReference type="eggNOG" id="KOG0955">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LANHAYA"/>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15670">
        <property type="entry name" value="ePHD_BRPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15492">
        <property type="entry name" value="PHD_BRPF_JADE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000008">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000007">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="261"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="315"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="11">
        <location>
            <begin position="627"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="767"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="776"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KTW32903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="790" mass="93164" checksum="A80626EE6E85C875" modified="2016-03-16" version="1">MVPRIDYKGESSCFSNSAHASRLAVINENNYEQITEKPREERSYLEFYTNFNINEPLRIIYSKDDHNSTVPLLSDDLNSSEIRKSYGELNQENDFDRNYDKCLGSKITKKEKHIFDSDMSCDISKQDKKSESKDEQLKNIENPYIQKSSKFSFRNIQPFEKEARYTGRSIMEYGYQEADIWNRPSDTYIRFVEESKETLANRVEYDMDEQEQYNSKRLKSEGDTISHELFEIVLTKIEKEWIELDKRMPKDQSKENLSPDDSKCSICDDGECENVNAIVFCDGCNLAVHQDCYGIPYIPEGQWLCRKCLISPQNTLNCIFCPNTSGAFKQTSDNRWAHLLCAIWIPEVTVMNTVYQEPIDNIHKIPASRWKLICYICQQRMGASIQCVNKSCYRAFHVTCARRAKLYMPMKKNNTELKAYCDKHVPSFWRNEHDIAKFLYDTRKQFLSYTPSTSEFVENNHNSNYIHGASSKIYINLKKAKTYPLIPVYIQNRILDYIHKFPIRKKSIFITDICKYWSLKKESRKNASLIKRLQLKTENEIRNLSTDQLSERIEFAKILKHDLEKLLELTDSVKKREEEKKKISCYLETMADGLYFPITHIIRYILNCIEGWDKNKLFSNIPIDTFNYNSINGMPTSLSMISKKIEDREYANLLQFKTDLMHVFDNAIKYNDHNTIYYKTAVKFKRQCEKLFLDAENSISFLKMENERMVSDWSIFEPKGLSIKEYVQIWPGDDIRTMSPLSEIADEEFNLLERHVNLIQKKDNLNKQNMKNDIKKKSKHNLRSRPQKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZX16</accession>
    <name>A0A0W4ZX16_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_04294</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="KTW32907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613379.1">
        <property type="nucleotide sequence ID" value="XM_019757813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZX16"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZX16"/>
    <dbReference type="GeneID" id="19896497"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04294"/>
    <dbReference type="eggNOG" id="KOG4686">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255148at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052187">
        <property type="entry name" value="MFSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KTW32907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="54212" checksum="EDCF91768C75CD23" modified="2016-03-16" version="1">MKFRKQADPIELSFLIARKENNANDCIEEKYQNDYASFFTKTQVQLNDKREQTVKIVLLFLIISSCFFENIFNMNIYTMQEGLNKGNTQSSSLIKGFIIINPIIPIIFGLLVEKYDAGTSLFPIYLTGIIFFSQCISIIATLLHWKYIVILGLFVSGLCMNPLVIVQETLLIETFQEDNLGFYISIMLSVGKLISFISSFFINTFSEHSIYHIKILFIVSSALSLFSFSKRCQFIFGVVFGTTPFIYFLNKIEYTHFLKNITATDISSAILLLSVALYPIIGWLNDNYGHRLVILLISLFMSLISFISLLLPIRYDTFFITLFSVGQSVSSIILVLLTIYISKNASTIFGFCKSMEIIGNDIMQSVIHIILNFNKKKELTNTDINAIIMLFSILNMFSLVFLAAFYRDDNIYNKKYINHCLYNLFHKKSKMMYQDIIFRSKEIALKLTQTYLGFIVTGLILNWILYVKVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0W4ZX57</accession>
    <name>A0A0W4ZX57_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Major surface glycoprotein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_04003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="KTW32949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613416.1">
        <property type="nucleotide sequence ID" value="XM_019757762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0W4ZX57"/>
    <dbReference type="STRING" id="1069680.A0A0W4ZX57"/>
    <dbReference type="GeneID" id="30671539"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_04003"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021041">
        <property type="entry name" value="Maj_surf_glycoprot_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003330">
        <property type="entry name" value="MSG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF421">
        <property type="entry name" value="CUTICLE COLLAGEN DPY-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02349">
        <property type="entry name" value="MSG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12373">
        <property type="entry name" value="Msg2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Major surface glycoprotein 2 C-terminal" evidence="2">
        <location>
            <begin position="934"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="758"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1099"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="807"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="845"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="875"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="908"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="919"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1107"/>
            <end position="1127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KTW32949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1150" mass="128029" checksum="C3246FD1C429688F" modified="2016-03-16" version="1">MAQPVKRQAAGQAAGNDEIKEEQVLGLIVKSDYSDDNKCKANLKHYCEELKKIDGKLESVDVKVKGLCENIDKKCGDLKDKVEKELNSFKTEVEKELNNLTDEKCRKYEEKCLLLEEADPSNLEEKCVKLRDRCYRQRRQGVAKEILLRALEGKVNDTNECKKMKEICQGLSEYSDELVFSCFNPDETCEYFRKNHGDNCKPLQKELEDKELVEKCQEYLEKCYFYGSSCKDTKCDKVKNKCKGKGIEYEGPKLDFSPVKEKPRFPEKIEVENLYKKEEAKGIIVGKPKYKTLRDLALLLIKGRNGNSPKEKCKKALEDCESFKHLDYGLEELCGDKDKEDRCKELVEVEDRCTNFKLELYLKGLSTEFEKDKESDYFSWGQVSKLVSREDCIKFESECFHLEGVCTNKIGKACENVRVACYKKGQDRVLNRYFQEGLKGLIGDLELVTENLEKCQKSVVGNYTKLKEDRRYFTKCHLPTKLCYELLDDVILQSEELEVVLNLRRDFPRKEDCVELKKKCKDLESDSYLNHEKCDTLNRRCEYLKVTEELRKKLLKRGDDALRTQGNCTAVLKKECEELSRRGKEDFSVSCALREETCSFMVEQTENECLFLKNNMDIGKIIEKIENGKRNETLVEELCTLFDPYCHQYIENCPDRLKKEKNSNKNGVCLQLEEKCKPFFEKLKLENELTHKLKGSLSDETKCKETLGKHCTEWKKEGNQTLNSLCEDAKKEELCKKLVKKVKEKCPTLKNKLDNEKDELEKKKDEYEKVKQESEKFAKEAKLVLSRPEQDRQGEGSKAQDGSVPKPVGPPVQPPAPAQPTPGGVPVPAPTLAPPAQPTSGGAPLPVPPPAPGAPGAPGTPGTPGTPGTPGTSGGAPAAPGAPAAPGTPGAPAGPAGPSGGTPAGSPAGPPAGPPAAPAAPGGSTPSGTTNTSNVILVRRTFVSGEVSEPEKKAFVATARALELYLELKEKCKSLKGDCEFRKDCPKCDAVCTEIDKLCEGIEGLKVTPHHTVISTATQTTTTTATTTTTTTTTTTTTTTTTTTATTTESVDGGKVTEECTLVQTTDTWVTSTSLHTSTLTSTSTVTSTVTLTSMRKCKPTRCTSDSSKETETQKEEEKEEEVKPNEGMKIRVPEMIKIMLLGVIVMGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NI79</accession>
    <name>M7NI79_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_03420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000017">
        <property type="protein sequence ID" value="EMR08253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875506.1">
        <property type="nucleotide sequence ID" value="XM_007877315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NI79"/>
    <dbReference type="STRING" id="1069680.M7NI79"/>
    <dbReference type="GeneID" id="19897107"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03420"/>
    <dbReference type="eggNOG" id="KOG0896">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063065_4_0_1"/>
    <dbReference type="OMA" id="NWSREST"/>
    <dbReference type="OrthoDB" id="6508832at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23807">
        <property type="entry name" value="UEV_UBE2V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000026">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="137" mass="15626" checksum="7FFB2BEE6C5C5F6B" modified="2013-05-29" version="1">MQIPRNFRLLEELEKGEKGFGDGTFSYGLVDIDDMSLSNWIGTILGPAHSVYENRIYSLKIYCDETYPDMPPVIYFLSKINLPCVNPQTGRVEPEQLSCLSNWKRDHTLETILIALRREMASSSNKKLPQPPEGSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NIF2</accession>
    <name>M7NIF2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_03188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875251.1">
        <property type="nucleotide sequence ID" value="XM_007877060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NIF2"/>
    <dbReference type="STRING" id="1069680.M7NIF2"/>
    <dbReference type="GeneID" id="19896875"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03188"/>
    <dbReference type="eggNOG" id="KOG1862">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_287156_0_0_1"/>
    <dbReference type="OMA" id="KESEWNS"/>
    <dbReference type="OrthoDB" id="48509at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051640">
        <property type="entry name" value="GRB10-interact_GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445:SF36">
        <property type="entry name" value="FI03272P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445">
        <property type="entry name" value="GRB10 INTERACTING GYF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="417"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="875"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="894"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1074" mass="122028" checksum="E5849299973F7241" modified="2013-05-29" version="1">MTTQNSMRFGPEWMRQGPHNNVPEGSTSFEVIQNKQQNEKNRQENISYLSSPSLSLQTSNTSKSPSTPSPGLLRYSKEFLLSIWKDMFMSEKGISKPSELNQFSQISSDEIITPVSLSEMSEDEKKLFIGPVNSEKKRRNLELVNNMVHGNAHFYTNRAYSPRNERFINSSRFDQKTRNKEVYEGFRNPRIQKSREYFSNTFSSEFWTPSSLRTNSETLTNNILSNENNETLPSSIKSEHSELRNVYTKENRNISLSKGIADLSISQINTPFLSSGTIRSPVESIGSIPGRNISRLQSLGMFESQSSSKISPTSTSSFQYDDSDDVLKEAMEHISEDKDKSLENFQNKLNTNLDINKSLENIQKEKTQFLGLFTPSDSSSLNKNSKIEKLFENSQQSNFSQPSPLQPPSRTPIMPDKLNWLYKDPMGVTQGPFSGLKMQDWYNAGFFQLTLLVKQVNDEDFEPLSSLIARVGNQKEPFLSPFYSKSQAISPVENFYDTVNGWNSPGQGSKLDHHLPGTTALGHIDSATPTTPGWNRQTQFPKSFSFGSNLPPEQHNSLESRKQEEYLMHHKKDMFQQQRLTQLAIQRQKLQNIQKQTQNQQERPMQVNFLRQTETFPLKSTKSTTSESIVRNKPLDEINISRIDKETPEFVPHFNKTAEEKLPNLDPVLSFVNTEQSDLLNFTRNSSEIIFSKPETIQFTNSNNIQKQPFQKKNEIYLKSSNANQILKQPLIKQKEPQKTQMHSVTPWANVLDDIKDISLREAQESEVKDSQNSTQEIFLNSEYSEKVNSIKKETHPIINNLPKTSAWGLPSSIPENSSDSISTHNLSSVWQSPGIPVKKSLTEIQEEQNMKANKYQKQLNINTMAASLSSKNHTNLLKKPSQSPWITVGPNGRSISRPSPVASSPRTNIDSSGVKPGNLEINQKKSNVSKFHIIQPINQSSNSTNSNISGNSAKNSSNDFFNWCKKSLKALNPGINLEDFLQMLMSLPVEPSQETIEIISDSIYANSAILDGRRFAEEFVKRRLENISLDNEALEKNIAIQSWTDALKSQKQKESEWNSTFKIVSNKKNKKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJ92</accession>
    <name>M7NJ92_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000014">
        <property type="protein sequence ID" value="EMR08688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874903.1">
        <property type="nucleotide sequence ID" value="XM_007876712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJ92"/>
    <dbReference type="GeneID" id="19896553"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02866"/>
    <dbReference type="HOGENOM" id="CLU_2832253_0_0_1"/>
    <dbReference type="OrthoDB" id="10299128at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004082385" evidence="1">
        <location>
            <begin position="22"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="66" mass="7680" checksum="45DB04A8684B4B85" modified="2013-05-29" version="1">MYFNGALIMGLLSLSIVPIQCIGSAIYSYDSAQVLNHKEFNRQPFVNHIQQINERWIPWFGRPIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NJX7</accession>
    <name>M7NJX7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LisH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02709</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874734.1">
        <property type="nucleotide sequence ID" value="XM_007876543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NJX7"/>
    <dbReference type="STRING" id="1069680.M7NJX7"/>
    <dbReference type="GeneID" id="19896400"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02709"/>
    <dbReference type="eggNOG" id="KOG0273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007609_1_1_1"/>
    <dbReference type="OMA" id="KWNKCGN"/>
    <dbReference type="OrthoDB" id="1367865at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.30:FF:000001">
        <property type="entry name" value="F-box-like/WD repeat-containing protein TBL1XR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045183">
        <property type="entry name" value="Ebi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846:SF2">
        <property type="entry name" value="F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN EBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="201"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="254"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="295"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="378"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="420"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="466"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="62575" checksum="654FF4C8352F6F9C" modified="2013-05-29" version="1">MNSNEVNYLIWRYLQESGFEHTTFTFQHESSAHLEDNRWSKEVSAGALINVLQKGLQYMEVEAHVDKNGSIKRCMLPFSLIGRHLCENGETVLPEVIETDLQEEKEKRVSLNMEDNEIYESNKGESLEFSEFSESKELKELMESREMNVFEGSNESRIERLNFPESSCFLEEKSHLELEASTISPTNASWLTKKMEKVVLLCGHQENVFTGAWNPVYLDFVATASADATVRIWNLLEKDSVNSLLDNLVLNCTPLNEKKDITSISWDNSGNYIAAGSYDGQVRIWSLKGTLKYLFTAHHGPIMGIKWNSKNNLLLTASCDSYVIAWDMFNGTLKHVYDRRPCAITDIEWISDETFASSGKDGSLDFWSAEKAELLRRWEGHSKEINSIKFNPHNNLLLSCSDDFAVKIWSLDISSPQKIFLGHSKSVVEVQWKPQQKTDEVIIFVSCSLDGTIKVWNTIQSSPLHSLSHGWAFFTISFNPSGDILAAGTKDGSVILYDIKEGYLCGKYDKSIDKNPNKNSVIEHVFDVSWSKKGDRIIVCRANSVAEVIYCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NK07</accession>
    <name>M7NK07_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAD hydrolase, family IA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_02737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874764.1">
        <property type="nucleotide sequence ID" value="XM_007876573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NK07"/>
    <dbReference type="STRING" id="1069680.M7NK07"/>
    <dbReference type="GeneID" id="19896428"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02737"/>
    <dbReference type="eggNOG" id="KOG2914">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_13_0_1"/>
    <dbReference type="OMA" id="IWCPHPG"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990738">
        <property type="term" value="F:pseudouridine 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000001">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR08958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="27246" checksum="D46E3092EEE1785E" modified="2013-05-29" version="1">MNQTDTLLPIKACIFDMDGLLINTEQLYTEVTNELLARYNKPKLSIEVKTQIMGIPGLEATKILIKSYEIEESAEKLYKEAGELQKKKFLETKEMPGSYMVLKYLKDQGIPIVLATSSSIRNFHIKTNHLSHIFSHFGENIVRGDDPRIPKGRGKPAPDIYLTALNIINNERKSKSLEPITSKEYSILGVQAGRSAGMRVIWVPEPDILKYFEEKKEEIIGTNNEILSSLENFNPKKYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M7NK20</accession>
    <name>M7NK20_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Ribosome biogenesis protein NOP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02748</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NOP53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874779.1">
        <property type="nucleotide sequence ID" value="XM_007876588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NK20"/>
    <dbReference type="STRING" id="1069680.M7NK20"/>
    <dbReference type="GeneID" id="19896439"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02748"/>
    <dbReference type="eggNOG" id="KOG2823">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035888_1_0_1"/>
    <dbReference type="OMA" id="AHELCEG"/>
    <dbReference type="OrthoDB" id="5072at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011687">
        <property type="entry name" value="Nop53/GLTSCR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211">
        <property type="entry name" value="GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211:SF7">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07767">
        <property type="entry name" value="Nop53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017302">
        <property type="entry name" value="Gltscr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="408" mass="48470" checksum="3F1DA2EAC5A4D57B" modified="2013-05-29" version="1">MSFRSLQSFRKEEKNLTKNIDLGNLRPGLEVLQEKINDDIFSKISDEKLFSVDFKGDISVCEKREDVKCLKNDEMLSYKSPILFLSNFSEKDLKNVNKSKSKKQMWRNMLNSEDIFLGKNSQKLNNLLNNIKISDQISSNDSKLYDIWKKDNNPQKLSLVNFSLQQRFPKMPSTLQHKPLSISNNVPNVEVANAGMSYNPLFQEYKKLIDKESTKELLREIKNDQERRKKSFNVFEQDSIKNKDPESLSENSNFTEEVHNCLINRKSVKKTRKQRKKEVRRKKEICEYNEKRRQKKQIKDLNSINKIVKSIEEKANSQKLANISDSIHEVRFRKKSRKHGAYVRPLEIQLSDELSDSFRLFKPEGNIFIDRFISLQERGLIETRYPVISYRKYPRRYVEKWNYKRFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NK24</accession>
    <name>M7NK24_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ketoreductase (KR) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02753</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874784.1">
        <property type="nucleotide sequence ID" value="XM_007876593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NK24"/>
    <dbReference type="STRING" id="1069680.M7NK24"/>
    <dbReference type="GeneID" id="19896444"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02753"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_1_1"/>
    <dbReference type="OMA" id="NYLANYH"/>
    <dbReference type="OrthoDB" id="191979at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF285">
        <property type="entry name" value="RETINOL DEHYDROGENASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="43522" checksum="8A07A3FCB4DF75E3" modified="2013-05-29" version="1">MPIPFIAHLINLSPVFYEKYVFTNIQKYISLIILFYLLKKCFSGANNKTDRRFNGSVFLITGGTSGIGAEVAKELAKRGAHIILLVRSCSDSWTIDYINDLRARTNNHMIFAETCNLSSLYSIRQFATKWIDNIPPRRLDMVICCAGVMLPPFKPKLVTEDGVELHWGINYLAHFHLLNLIFPALRSQPPGRDVRVVLTICSTYMLGDLDLMDLEFHRRGYPSSRPWKCFGASKIALMNFAREFQNRISNYKRPDEFPNNVRCYVVDPGFVRSHMTLRFLSFGSLWGLLLYIIMWPLWYIVLKSCKQGAQSLLYCIMSSECGTGQGGKLIVKCSLRDISTKKYINSDISSSLWKITETYIMDVEKKEAIKRNILKKKCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M7NK32</accession>
    <name>M7NK32_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">26S proteasome regulatory subunit RPN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_02762</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proteasome subunit S2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874794.1">
        <property type="nucleotide sequence ID" value="XM_007876603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NK32"/>
    <dbReference type="STRING" id="1069680.M7NK32"/>
    <dbReference type="GeneID" id="19896453"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02762"/>
    <dbReference type="eggNOG" id="KOG2005">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008705_1_0_1"/>
    <dbReference type="OMA" id="GTCNGDI"/>
    <dbReference type="OrthoDB" id="10252509at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905754">
        <property type="term" value="C:ascospore-type prospore nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000026">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016643">
        <property type="entry name" value="26S_Psome_Rpn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041433">
        <property type="entry name" value="RPN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040892">
        <property type="entry name" value="RPN1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18051">
        <property type="entry name" value="RPN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015965">
        <property type="entry name" value="26S_Psome_Rpn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RPN1 N-terminal" evidence="7">
        <location>
            <begin position="35"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit RPN1 C-terminal" evidence="8">
        <location>
            <begin position="810"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00057191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR08988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="868" mass="96814" checksum="44F30D328B593844" modified="2013-05-29" version="1">MNGETKQINQNLKKGKDKNDAEELSEEDNQLKANLNILVERLKESDISLHGPSLESLKVFIRTSTSSMTAVPKPLKFLRPHFFDLIQIYETWPASEQKAVFADILSVLGMTYAKDGKRESLKYCLLGKKNDIGFWGHEYVRHLSAEIGEEYSIRIENDSSTDDLMDLALRIVPFFLTHNAEADAVDLLLELESIEKLPPFIDSNTYARVCSYMVSCVNLLAPPDDVAFLKTAHAIYKSQGKIAQALILAIRLGDYELIKNDFNSTSDLSIKKQLAYLIARQQIWFEDDDESINECLRNSRLSELFRFVAKELNVFEPKTPDDIYKSHLEVRSSSLTSAIDSTKQNLASTFVNAFVNVGFGNDKLVLSEDCNTSWIYKNKDTGMMSAVASIGMIMLWDIEMGLTQIDKYLYSSDENIKAGALLGIGLINTGVHDESDPALALLGEYLENKDTKIRISAIVGLGMAYAGSNMEDIMELLLPFVNDTELHMEVSSLAALSLGMIFVGSCNGDITSAILQTMMERENKCLEEKWGCFMSLGLALLYAGKQDASDATLEILKAINHPIVRQASVLVDIFSYAGTGNVLKIQGLLHICSSHLDTDKEKNDLHQGFAVLGLALIAMGEDIGAEMILRQFDHLMYYGEPVIRKAVPLALGLLSASNPQIKIFETLSRYSHDTDIDVAINAIFAMGLVGSGTNNARLAQLLRQLSSYYYKTPNALFMVRVAQGLLHMGKGTMTLSPYHTDRQIMSYVSMSGLFTVLVTMMDSKSFILDTSHWILYYLTMAIHPRMLLTVDESGNFQKTVVRQGTAVDIVGQIGRPKTITGFQTLETPTLLQHSDRAELATDEYISLTPTLEWIVILRKNPNYMEEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M7NK55</accession>
    <name>M7NK55_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PNEG_02788</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874819.1">
        <property type="nucleotide sequence ID" value="XM_007876628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NK55"/>
    <dbReference type="STRING" id="1069680.M7NK55"/>
    <dbReference type="GeneID" id="19896477"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02788"/>
    <dbReference type="eggNOG" id="KOG0346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_17_1_1"/>
    <dbReference type="OMA" id="NASEQCV"/>
    <dbReference type="OrthoDB" id="1191041at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033677">
        <property type="term" value="F:DNA/RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17961">
        <property type="entry name" value="DEADc_DDX56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF21">
        <property type="entry name" value="DEAD-BOX HELICASE 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="49"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="237"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="319"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMR09013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="589" mass="68429" checksum="5AAF27DDD9C24288" modified="2013-05-29" version="1">MDKEHDNKYKENSANAHNTFSSFCLDPRIVRAVLKLGFRSPTYVQSQVIPLALEGKDIFVQARTGSGKTAAYLIPIIENILKNKESQKQSETRSLIIVPTRELSNQVTNNIKELTFYCGKVIRVVNLAANISDNAARILISECPEIVVGTPSRIIVHLNASNLHIQESLLHFVIDEFDLILSYGYSEDFDNIMKYIPKRVQMLLTTATFTEDLDKLKKVICKDPVILKLEEKDSYSNLSQYSVRCSEDEKFLLIYVILKLRLIKGRIIIFVNNIDRCYKVKLFLEQFGIRSCVLNSELPINSRLHTIEEFNKNVYDIILATDENNLSKESDSIDDMQENINNESTKIISKKDNSVLKKRKRIHKDGEYGVSRGIDFKDVACILNFDLPTTVKSYIHRSGRTARANKSGMVISFIVPEKLWGKHKSILLKTAKYDESIFEKIKEDQEIKGITIKPYNFNMEHVNAFRYRMEDALRAITRTVIREAREKELRMEVLSNEKLKKYFDENPNDLQQLRHDKELHPTRIQPHLKHVPNYLLPKKERINITENIGHVSFHKKNMNRINKVRVSNLKKRTKYFKNKNDPLKSFKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7NKI8</accession>
    <name>M7NKI8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">4-hydroxybenzoate polyprenyltransferase, mitochondrial</fullName>
            <shortName evidence="10">4-HB polyprenyltransferase</shortName>
            <ecNumber evidence="10">2.5.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Para-hydroxybenzoate--polyprenyltransferase</fullName>
            <shortName evidence="10">PHB:PPT</shortName>
            <shortName evidence="10">PHB:polyprenyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_03611</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>an all-trans-polyprenyl diphosphate + 4-hydroxybenzoate = a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44504"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Mitochondrion inner membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
            <orientation evidence="2 10">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="10"/>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874627.1">
        <property type="nucleotide sequence ID" value="XM_007876436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NKI8"/>
    <dbReference type="STRING" id="1069680.M7NKI8"/>
    <dbReference type="GeneID" id="19897298"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03611"/>
    <dbReference type="eggNOG" id="KOG1381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034879_0_2_1"/>
    <dbReference type="OMA" id="WCMIYDT"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000003">
        <property type="entry name" value="4-hydroxybenzoate polyprenyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01635">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01474">
        <property type="entry name" value="ubiA_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="312" mass="35016" checksum="163CDFFB34A98A79" modified="2013-05-29" version="1">MLKLKLRKINKLSIQKFFIPYAQLARWNNPIGAWLLYLPSTWSITMAAYSQTISAHETLSMLGLFGAGSILMRGAGCTINDLWDRKIDARVERTAMRPLASGALSARQAIAFLGLQLAGGAGILIQLPVECQLLGASSLIFVTVYPLMKRITWYPQVVLGFTFNWGILLGWPALVGWDHVTWGSCLPLYISGIIWTVMYDIIYAHQDKRDDAQASVYSMALKLGKHTKPWLFALSMLQTTTMAWAGYMNGHSPIFYIFGCGSGIIYTIWMLRTINLNKPSNCWLWFIRSKHAGILMGTGPLIDWIIRITSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M7NL27</accession>
    <name>M7NL27_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">2-(3-amino-3-carboxypropyl)histidine synthase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_02309</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874308.1">
        <property type="nucleotide sequence ID" value="XM_007876117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NL27"/>
    <dbReference type="STRING" id="1069680.M7NL27"/>
    <dbReference type="GeneID" id="19896002"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02309"/>
    <dbReference type="eggNOG" id="KOG2648">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015210_1_0_1"/>
    <dbReference type="OMA" id="TSNSRPM"/>
    <dbReference type="OrthoDB" id="449241at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010014">
        <property type="entry name" value="DHP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00272">
        <property type="entry name" value="DPH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR09358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="462" mass="52942" checksum="4334A19FAF35A09B" modified="2013-05-29" version="1">MEKPLDPVDYLENKYEISNTKKFIEEGCFQRVALQFPDELLKDATNVFQRLSIETKASFFILGGTSYGSCCVDEIEAQHVNADCIIHYGHACLSITTRLPVKYVFDKPSSLFNINKCLDKFKAIYNTEDYIILVGKPCYINILESIFSKLISFGYNRIIKGEGEYSAINITKAIGEAIVADDKQRLDLYKKWSIFYIGEKSPGLTTLAMTCYSHVMSFYSYNPEQDEVIHQSPISDIQLRRRYAIIQKAKDVSIIGIVVGTLGVSRYLEVTYHLREMIKKAGRKCYMFIIGKLSPEKLANFSEIQIFVLVSCSENSLIESKDFYRPIITPYELYLALSSEIWNKQWITDFSSILCLNLKEDELIRKDEPQFSLATGHLIQPSIIQDDEILIKNDSLSNSHKGIMKLNEHMELSNTRIHSVSAYFHKNTKSWHGLSKLEIQTEPSKLETGQQGIASKYDHEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NL35</accession>
    <name>M7NL35_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mRNA-capping enzyme subunit beta</fullName>
            <ecNumber evidence="8">3.6.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-triphosphate monophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_02317</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:67005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the fungal TPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="8"/>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874317.1">
        <property type="nucleotide sequence ID" value="XM_007876126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NL35"/>
    <dbReference type="STRING" id="1069680.M7NL35"/>
    <dbReference type="GeneID" id="19896010"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02317"/>
    <dbReference type="eggNOG" id="ENOG502RZAX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018004_1_0_1"/>
    <dbReference type="OMA" id="HHMIMTR"/>
    <dbReference type="OrthoDB" id="272147at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07470">
        <property type="entry name" value="CYTH-like_mRNA_RTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.10">
        <property type="entry name" value="mRNA triphosphatase Cet1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040343">
        <property type="entry name" value="Cet1/Ctl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004206">
        <property type="entry name" value="mRNA_triPase_Cet1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037009">
        <property type="entry name" value="mRNA_triPase_Cet1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118:SF1">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE CTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02940">
        <property type="entry name" value="mRNA_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA triphosphatase Cet1-like" evidence="10">
        <location>
            <begin position="103"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="356" mass="40729" checksum="FF3D4B261D1AF084" modified="2013-05-29" version="1">MLDKKEAPVSTETLDSSSISSENFPSVKYQSLTGMSGEDPSKKPCSETPSSISCEKYAGVVDISSNTLDNERSDFLSCQISSKQLFTPKPLSEPSFLNLVPHDELIRFVSDFLFHNCITESLKYVEIEAKIGHIVDVITGERLWLPVLTETIINSNELKIKFESNMTELQHKYFNRFLNASFEKSQIKNKGQPRVPMKYKHTKEIDKFYNNLSLGQGFQNRVRITTDKKTGQIISRLIKTRVASLNIFSPRTQFDWRLSVNIEMPFEPRPLGALVMERDKDRLSYVHQFCQIDLSQVISENGSKTHELEVELLDIDELKKHGNAASHGQPNNFENIVRIFVDNVRILVRQNITNTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M7NLJ3</accession>
    <name>M7NLJ3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PNEG_03507</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">B123</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="AFWA02000016">
        <property type="protein sequence ID" value="EMR08067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875599.1">
        <property type="nucleotide sequence ID" value="XM_007877408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NLJ3"/>
    <dbReference type="STRING" id="1069680.M7NLJ3"/>
    <dbReference type="GeneID" id="19897194"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03507"/>
    <dbReference type="eggNOG" id="KOG0578">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_26_2_1"/>
    <dbReference type="OMA" id="HTETIGI"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000768">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="417"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMR08067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="691" mass="76777" checksum="F5970F483C55AF2A" modified="2013-05-29" version="1">MIMKGQIQDSRSSSPSLSPFNNKNSNLSSVSAGSKYSNTSEQIIFDPPALELVPHRPAPKPPSVLKKTENFSNNTHGSIHSRSAPEVWKSIPGPFTPPTQQSNTWTRSPPYSHGFTRTCIITSESMTSSTPTKSYGSSNHILSPPTTGGSGKSTKSAFGHFMSNITEILGSQKKTEISSPYDLVHLTHVDFNAKTGEYNGLPKEWQKLLSDCGISEKEQEENFHAIMDIVSFYADGMSSPVLSVADDDLADDFSGLDPFKTKSPKTPSLSSSMTIFPKKRGVLQDIPSLPADAKQRILEASKKVDIPLHPLSSKGFFSSKKVWGAPVTTLKKPRNPNFNSKKQEISSKKAAHPLKPYISFPKSDTSSLLNNNLDKSFQDLQNDPSKQSETRKTSNIGSQTLLRLRLICNTEDPTRLYRNLVKIGQGASGGVYTAYQVGTNMMVAIKQINLGNQLKRDLIVNEILVMKQNKHENIVNYIDSFLLKDDLWVIMEYMEGGSLTDVLMSNIMTESQIATVVKEVLKGLIYLHSKGIIHRDIKSDNVLLSLDGLIKLTDFGFCARVNEAMNKRTTMVGTPYWMAPEVITRKEYGPNVDVWSLGIMCIEMIEGEPPYLDENPLRALYLIATNGTPRITQLQNLSQPFRDFLHLTLQVNPEQRPSSSTLLSHLFFNKVLPLNCLIPLIRVARKHSKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NM68</accession>
    <name>M7NM68_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoporin Nup54 alpha-helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_01938</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873914.1">
        <property type="nucleotide sequence ID" value="XM_007875723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NM68"/>
    <dbReference type="STRING" id="1069680.M7NM68"/>
    <dbReference type="GeneID" id="19895632"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01938"/>
    <dbReference type="eggNOG" id="KOG3091">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023804_0_1_1"/>
    <dbReference type="OrthoDB" id="6162375at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024864">
        <property type="entry name" value="Nup54/Nup57/Nup44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025712">
        <property type="entry name" value="Nup54_alpha-helical_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000:SF0">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13874">
        <property type="entry name" value="Nup54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup54 alpha-helical" evidence="4">
        <location>
            <begin position="223"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="442" mass="48927" checksum="0ADED1D20AE817DC" modified="2013-05-29" version="1">MFFQGQTGSKFNELKGFNGTQTMITPTVTTPAPTSVPIAGITPTNNLFGTSSLGPMVSGMVSSTSSGATSTLGTTLGSITQNTSMGIPTSTSTSTIATGTSDTLKAPLQSSISTSFGGFSQQSTLSNLPIYSWGAPFQKIVSRFQPLQIQTPVDTLAEDRSKSGVSQSEILGSSSILGLDQFPSVVDQLQKLKNAWDPAHPDCAFQYYFYNRVPIDQVALYVKPSHHNQQKWNEAIANRPENSVVPALAIGFSDIQKRVQLQEQQVTTYRVRMHEIINKLKELSQKHDLSTTVKISEATLRHLELSRRSLALAAKVQILKGRGYALQPEEENLKQRLIELSKSLNDPGVFGKINELWARMTFVREKAKSIERARQGKIIMNINWRRDEEQLDKITKVLSDQHAGILYVINILKNDLNEVDKALEKIQEHKKSLEQPKPRGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMB6</accession>
    <name>M7NMB6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="13">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_03192</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 13">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="13"/>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875255.1">
        <property type="nucleotide sequence ID" value="XM_007877064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMB6"/>
    <dbReference type="STRING" id="1069680.M7NMB6"/>
    <dbReference type="GeneID" id="19896879"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03192"/>
    <dbReference type="eggNOG" id="KOG2978">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_13_3_1"/>
    <dbReference type="OMA" id="KCFRREV"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006720">
        <property type="term" value="P:isoprenoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000036">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="14">
        <location>
            <begin position="6"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR08352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="238" mass="27333" checksum="3FA52BA67F550212" modified="2013-05-29" version="1">MTDKYSIILPTYNERKNLAIITYLLWKLLNEGNFDWELVIIDDNSPDKTQEVANKLIEIYGSDRIILKTRPKKLGLGTAYVYGLEFCTGNFVIIMDADFSHHPKYIPEFIHLQREKSYDIVLGSRYISGGGVYGWNVKRKLISLGANLLSRIMLQHGVSDVTGSFRLYKKSVLKEIIADCKSKGYVFQMEIIVKAKKYGYSVGEVPITFIDRLYGESKLGRDEIIGYLKGLWDLFYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMC0</accession>
    <name>M7NMC0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">UEV domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01989</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873969.1">
        <property type="nucleotide sequence ID" value="XM_007875778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMC0"/>
    <dbReference type="STRING" id="1069680.M7NMC0"/>
    <dbReference type="GeneID" id="19895683"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01989"/>
    <dbReference type="eggNOG" id="KOG2391">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017548_2_0_1"/>
    <dbReference type="OMA" id="YMNFPQP"/>
    <dbReference type="OrthoDB" id="306304at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072666">
        <property type="term" value="P:establishment of protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052070">
        <property type="entry name" value="ESCRT-I_UEV_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017916">
        <property type="entry name" value="SB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306:SF3">
        <property type="entry name" value="TUMOR SUPPRESSOR PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306">
        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09454">
        <property type="entry name" value="Vps23_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51312">
        <property type="entry name" value="SB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UEV" evidence="10">
        <location>
            <begin position="5"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="SB" evidence="9">
        <location>
            <begin position="344"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="279"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR09808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="47019" checksum="8CDCD4305B212574" modified="2013-05-29" version="1">MTTLKALDWVKKVVFDNYTFAKRTYEDIKDIIDSYPSVDVWIEERQSEKREKKCILCIKVVLQVVSFEKTYDIPVVLWVPLLYPREAPIVSLVIEEGFVIKQGNYVHSDGRCYHPCIEFWDEYSCESTLIRLFVSLKKAFSKDVPIVFLQSGCIFKSSCSTSSKDLSNDYDLSAISKSQTSLEQSSPPPLPDKPPSFLIKTPFSLQKNNLIELPQKKSVNILDSACIDAGVPSMSSSNFDLVKKPLNPIVEQLIKQIAITLQENAQTSQKTIAQLLFQVKNDREKILRSQAQIEREKTEITHIKEQCQKNIDILKEKIESSKLLIEKCKNMQEPSIDDIVIPGNALSEQFYDLISDEKSIEDTIHVLVKMLEKERIDFDTFLKYTRNLAREQFMKKALIRKIKKLESSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMN9</accession>
    <name>M7NMN9_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Golgi phosphoprotein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_03233</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOLPH3/VPS74 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000010">
        <property type="protein sequence ID" value="EMR08396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875299.1">
        <property type="nucleotide sequence ID" value="XM_007877108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMN9"/>
    <dbReference type="STRING" id="1069680.M7NMN9"/>
    <dbReference type="GeneID" id="19896920"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03233"/>
    <dbReference type="eggNOG" id="KOG3983">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036311_1_0_1"/>
    <dbReference type="OMA" id="GETWNLL"/>
    <dbReference type="OrthoDB" id="2189106at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048194">
        <property type="term" value="P:Golgi vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060304">
        <property type="term" value="P:regulation of phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3630.10:FF:000004">
        <property type="entry name" value="Probable VPS74-protein involved in protein-vacuolar targeting"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="entry name" value="yeast vps74-n-term truncation variant domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704:SF2">
        <property type="entry name" value="GOLGI PHOSPHOPROTEIN 3 HOMOLOG SAURON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="TRANS-GOLGI PROTEIN GMX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR08396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="40650" checksum="538153D37AD1CDDC" modified="2013-05-29" version="1">MLIMSSGLFRRRVGNSGPNRYVETSSTRNYQEEDLNRESLGKECCNIDKKKYKIVFDPLDLQEDEERRKQPCLTLMEEVLLLGLKNKQGYLPFGNDNISYILRGCIILELAFRGRIQMCRDSLRKRHPLPERIVEVVNDKTTGETLLDETLKMMKTSEKMTIGSWVDLMSGETWNFMKIGYQLKQVRERLAKGLVDKGILRTEKRNFLLFDMTTHPISNNFVKDDICNRLVVMLTAPTIVLPTSVFFPETISMRHLRVISLVCAAYAANVLENVFSSVEYEVRERAFTRVDEFFKEFSQWPFTIKYSSNINCVDSNLADVIAEETSGGKDKELQLEVIAAVLQIFTRFDCIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMQ1</accession>
    <name>M7NMQ1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major surface glycoprotein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08507.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875039.2">
        <property type="nucleotide sequence ID" value="XM_007876848.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMQ1"/>
    <dbReference type="STRING" id="1069680.M7NMQ1"/>
    <dbReference type="GeneID" id="19896677"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02990"/>
    <dbReference type="eggNOG" id="KOG3544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_441870_0_0_1"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021041">
        <property type="entry name" value="Maj_surf_glycoprot_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003330">
        <property type="entry name" value="MSG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF421">
        <property type="entry name" value="CUTICLE COLLAGEN DPY-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02349">
        <property type="entry name" value="MSG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12373">
        <property type="entry name" value="Msg2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Major surface glycoprotein 2 C-terminal" evidence="3">
        <location>
            <begin position="976"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="800"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1067"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1141"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="77"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="800"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="849"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="887"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="917"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="950"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="961"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1149"/>
            <end position="1169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08507.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1192" mass="132859" checksum="36682E9002E51549" modified="2016-03-16" version="2">MYGYFERIISRSTFDLPSHMLLRDKRWVEEVAQKEAAKAQPVKRQAAGQAAGQAAGNDEIKEEQVLGLIVKSDYSDKDKCKKKLEEYCEELKKIDKKLENVDDKVKGLCENIDKKCGDLKDKVEKELNSFKTEVDEALKGPTDEKCRKCEEKCVLLEEADPSNLEEKCVKLRDRCYGQRRQEVTKEIFLRALEGKVNDTDECKKKMKEICQGLSEYSDELIFSCFNSDKACNGLKVSYLDSCKPLETELKDNELVEKCQEYLEKCYFYGSSCSNSKCKESKEKCGKKGIVYEGPKLDFSPVREKPRFPEKIEVENLYKRLGAKGIIVGRPKYKTLQDLILLLIKERNEKDDKEKCKGALKGCESFKHLDYRLGELCEDKDKDKKCEELVDVEDRCTNFKLELYLKGLSTEFEKNKESDYFSWEHVSKLVTKEDCRKFESECFHLKSVCTNKVEKACENARVACYKKGQDRILNRYFQEELKGLIGDLELVDENLEKCQKSVVGNYKKLKEDKRYFEKCHRPTELCYKLLDDVIFQSEELEIVLNLRRDFPSKEDCVELKKKCEDLESDSYLNHEKCDTLNRRCEYLKVTEELRKRLLKRGDDALRTQGNCTAVLKKECEELSRRGKEDFSVSCALREETCSFMVEQTENECLFLKNNMDIGKIIEKIENGKRNETLVEELCTLFDPYCHQYIENCPDRLKKTNNAGRKGVCLELEEKCKPFFEKLKLENELTHKLKGSLSDETKCKETLGKHCTEWKKEGNQTLNSLCEDAKKEELCKKLVKKVKEKCPTLKNKLDNEKDELEKKKDEYEKAKQESEKFAKEAKLVLSRPEQDGQGGGSKAQDGSVPKPVGPPVQPPAPAQPTPGGVPVPAPTLAPPAQPTSGGAPLPVPPPAPGAPGAPGTPGTPGTPGTPGTSGGAPAAPGAPAAPGTPGAPAGPAGPSGGTPAGSPAGPPAGPPAAPAAPGGSTPSGTTNTSNVILVRRTFVSGEVSEPEKKAFVATARALELYLELKEKCKSLKGDCEFRKDCPKCDAVCTEIDKLCEGIEGLKVTPHHTVISTATQTTTTTATTTTTTTTTTTTTTTTTTTATTTESVDGGKVTEECTLVQTTDTWVTSTSLHTSTLTSTSTVTSTVTLTSMRKCKPTRCTSDSSKETETQKEEEKEEEVKPNEGMKIRVPEMIKIMLLGVIVMGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMS8</accession>
    <name>M7NMS8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">THIF-type NAD/FAD binding fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_01745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR09988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873709.1">
        <property type="nucleotide sequence ID" value="XM_007875518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMS8"/>
    <dbReference type="STRING" id="1069680.M7NMS8"/>
    <dbReference type="GeneID" id="19895439"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01745"/>
    <dbReference type="eggNOG" id="KOG2014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002556_4_1_1"/>
    <dbReference type="OMA" id="EFFGQFD"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF162">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="2">
        <location>
            <begin position="14"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR09988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="322" mass="36575" checksum="8D7E6E0ECC36ED8D" modified="2013-05-29" version="1">MTKKTISQDEINIYDRQIRLWGIDAQTSISNSHVLLVGVRELAEEIGKNLVLAGIGSLTLLDGEKIKNIESNAHFCINVTDIGKTYAEAVSNVLKKFNSSVKLIANTTNIYEVPDDYFSSFDIVISCELELDLMMRLNTICRKYKVAFYSCAMYGFYGYIFSDLIKHTYSIEKKMSGRLKESVRIQSTEHYYPLSEIIHHKYGETLTQKRKKKVSPLLPGIIGLWKFQQKFSHFPSNSEEITQYLSLIKEINSQFGLSEDILENNVLVNLAKKANCKWSPVASVIGGILAQDILNVLSKQERPIQNLFFFDGEICAGPIYQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMU3</accession>
    <name>M7NMU3_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_01760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873725.1">
        <property type="nucleotide sequence ID" value="XM_007875534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NMU3"/>
    <dbReference type="STRING" id="1069680.M7NMU3"/>
    <dbReference type="GeneID" id="19895454"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01760"/>
    <dbReference type="eggNOG" id="KOG2478">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021991_3_0_1"/>
    <dbReference type="OMA" id="LVCRIKY"/>
    <dbReference type="OrthoDB" id="10260285at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033696">
        <property type="term" value="P:heterochromatin boundary formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007133">
        <property type="entry name" value="RNA_pol_II-assoc_Paf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188:SF12">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03985">
        <property type="entry name" value="Paf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR10003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="379" mass="44101" checksum="7242BB9A1CEC282B" modified="2013-05-29" version="1">MTSRRQDYIFRVRYQNKLPLPPFFPKMLNIPIPLNNYTKTSYLSSLIQEQPIDIELDSELGIPLDLSMISNVFEGIYDNMHGNPKNVELDPKDLVLLKEISSIPQRNSTGVSFLRRTEYISSESVKTAIKPKTFDSRFIKSIDSTNEKLEDPKKQVIAIETTFKEASKDWLSFKHPHKKNLTVVDSFPIFPDINISDQQFLLMKFTTDPEQNNFSSEMSNDCRSDLALFMPVSGRGEEWLAYYLPEQKSYNELKKTLKDQNSEKNETPFIYNHVHDYDTTMHINSTPLDEIALVFRNDPKTKLKSAFYSPIYAKSTLKRRRLKIPNGMVKNLNVSNIELKLRPLNEEESREKKKHCSMLDIHNCFNANELKEEKDINIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7NMV8</accession>
    <name>M7NMV8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Midasin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_01773</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the midasin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000008">
        <property type="protein sequence ID" value="EMR10018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873740.1">
        <property type="nucleotide sequence ID" value="XM_007875549.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NMV8"/>
    <dbReference type="GeneID" id="19895467"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01773"/>
    <dbReference type="eggNOG" id="KOG1808">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ILEQWHR"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000142">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000582">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000712">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001368">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040848">
        <property type="entry name" value="AAA_lid_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048617">
        <property type="entry name" value="MDN1_AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012099">
        <property type="entry name" value="Midasin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041190">
        <property type="entry name" value="Midasin_AAA_lid_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17865">
        <property type="entry name" value="AAA_lid_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17867">
        <property type="entry name" value="AAA_lid_7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21108">
        <property type="entry name" value="MDN1_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010340">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="12">
        <location>
            <begin position="4846"/>
            <end position="5048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="4295"/>
            <end position="4342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="4373"/>
            <end position="4402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="4450"/>
            <end position="4480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4297"/>
            <end position="4317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4330"/>
            <end position="4342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4373"/>
            <end position="4395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR010340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR10018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="5058" mass="588720" checksum="23B013A736F24105" modified="2013-05-29" version="1">[encoded data, 5058 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN15</accession>
    <name>M7NN15_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_03099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000015">
        <property type="protein sequence ID" value="EMR08622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007875154.1">
        <property type="nucleotide sequence ID" value="XM_007876963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN15"/>
    <dbReference type="STRING" id="1069680.M7NN15"/>
    <dbReference type="GeneID" id="19896786"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_03099"/>
    <dbReference type="HOGENOM" id="CLU_426481_0_0_1"/>
    <dbReference type="OrthoDB" id="5362656at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="606"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR08622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="642" mass="73652" checksum="8D232967FE1F6FB7" modified="2013-05-29" version="1">MGQNNLVLFNTTSCIYILNFSLKEDFLGTFFLPTIRLRIGISEPFIARSSSDGRFIAISMDFVYLYDLKDSEKVFVVPNSENVKHFVFGDNSDEFFFINEKDQVMNYNIRNNKISSLATQKRHPSPITFMTISKDSRFILTVSENPSIIFVQDCNTGLMNKIISGMAFSDVTNAVFHPQRSNIFFLLFSNGVLGFYDVKKPMQLIFKIKDLSITSASFLPNENSSAISIDLNGQISIIDFEKRNVQVKWSIDFFSDLLFVKELNDGGWNVFITSNEKCFYFNQEGLKLSEYSFDNSEKIIQISTLANDIHISEKFSDIVIEKSNLKVSRSSFSTNIQDCSPGEEIQSLDNKFLNSFFLEDNVSKSIVDGIHSEIENKFHKNQNNICSKKELHISDTKISGNNLSIVSIGKENIPLENSTKKISTTNMLAKESSTPIFSNNVFSPSKIHEIRPGFKFETPKSSKKILKSSTKRFDKRDFQINETVSEKLFEKHIETPSTTDIWLKFETNQNTDIKTPALDRLTLGKHVQNSEIDDLIKTSDISFSSFKSQKSDVFLTKELQSNLKKSDFFSDNMLTFKDMLLESQKGIRQDIQNLHVELIKQFMLQKLEFEKILKFKNKEIKNLKKENRKLAHELSVYRGGCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M7NN93</accession>
    <name>M7NN93_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PNEG_01432</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873372.1">
        <property type="nucleotide sequence ID" value="XM_007875181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NN93"/>
    <dbReference type="STRING" id="1069680.M7NN93"/>
    <dbReference type="GeneID" id="19895129"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01432"/>
    <dbReference type="eggNOG" id="KOG0764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_6_1_1"/>
    <dbReference type="OMA" id="CLQYADH"/>
    <dbReference type="OrthoDB" id="10266426at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF1">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06780)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="64"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="166"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMR10158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="31326" checksum="536CD89F24564213" modified="2013-05-29" version="1">MKAYKGFYNTLLRIWFEEGIRGFYRGLGPLMAGYFPTWGIYFTIYERCKDIYGRSYNSESIQKASLIVNMKSAITAGSISSILTNPIWIVKTRLMSQNSHSYIYYRNTFDAFRKMYTNEGIFSFYKGLVPSLIGVTHVAIQFPLYEFLKDVFFIDIVDFEKPLLFKVVLASVISKMVAGSITYPHEVIRTRIQTQMYHKDSPKIQYRGVFHTFCRIYYEEGWKSFYSGMGTNLIRTVPVSMVMLLTFEILNKWLFQIKHRHHEYIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M7NNL8</accession>
    <name>M7NNL8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_02634</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874653.1">
        <property type="nucleotide sequence ID" value="XM_007876462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NNL8"/>
    <dbReference type="STRING" id="1069680.M7NNL8"/>
    <dbReference type="GeneID" id="19896325"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02634"/>
    <dbReference type="HOGENOM" id="CLU_169286_1_1_1"/>
    <dbReference type="OrthoDB" id="532630at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR08847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="65" mass="7661" checksum="7C523A64B64F5806" modified="2013-05-29" version="1">MHPPLSAHKHPDCYELMKELERCHESNLISHFFGKCNDLKKKVVKCLNQEVIEAFEKYCLCFIGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP17</accession>
    <name>M7NP17_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_02628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AVL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874647.1">
        <property type="nucleotide sequence ID" value="XM_007876456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP17"/>
    <dbReference type="GeneID" id="19896319"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02628"/>
    <dbReference type="eggNOG" id="KOG3823">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009066_0_1_1"/>
    <dbReference type="OMA" id="IRTQFRV"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051731">
        <property type="entry name" value="DENND11/AVL9_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017:SF1">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="12"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR08841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="570" mass="66308" checksum="8182F4FF5C3E36D2" modified="2013-05-29" version="1">MDNPSKGKQSVLYIICVGFHHARGPEIEYCYPELQEIPSTWSLLPFMALPDGVHLNEEDFSYFCIKNDQKNTSTNNNNHILLTIYGISCTRQLLSSELINKPVDVTRSTIQKSIVVLVSKPVFGHIKEKLRAVTQAYFSQRNFEDRNILIHLYNSLVQIFHDEINGYDIYLGIPLRELLYQFRWKTLVILKAMLLEKRILFYGTRSETLCMIQYSLLSLIPELLENLQDASDPLLNTVENQLTKPTSLSTSNHKSLLSYMGMPFQIFAKGSFFGPYTPLQQIKMLDNKTTKSYIIGSTNSLFLQMKKKYADLVVNIDTGEVDILQPLLKNVLSLSFSDRKWINNIIMSVIDSWDESDTSRPKTMGFLNSEEHLRAQFEEYFLALAATVKYDNYLAKIKNSPDFNITSLDTYENIIREFGQCWIEQWKFTENYRLWNKYTDDELFNIIYPRHPVINRRISLEDVQHKISKQVQELKLNERAAIAKETINRSWNNGSQKISQVVGSLLDQMESYRTERWKRYQENHNQYITSVSLIGSELSSHFGDMQNKAGNYVSIFTDWASNKKRTIKHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M7NP35</accession>
    <name>M7NP35_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Polyprenal reductase</fullName>
            <ecNumber evidence="5">1.3.1.94</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_01187</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a key role in early steps of protein N-linked glycosylation by being involved in the conversion of polyprenol into dolichol. Acts as a polyprenal reductase that mediates the reduction of polyprenal into dolichal in a NADP-dependent mechanism. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a di-trans,poly-cis-dolichal + NADP(+) = a di-trans,poly-cis-polyprenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:80727"/>
            <dbReference type="Rhea" id="RHEA-COMP:19536"/>
            <dbReference type="Rhea" id="RHEA-COMP:19537"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:231623"/>
            <dbReference type="ChEBI" id="CHEBI:231637"/>
            <dbReference type="EC" id="1.3.1.94"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:80729"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the steroid 5-alpha reductase family. Polyprenal reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.94" evidence="5"/>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873103.1">
        <property type="nucleotide sequence ID" value="XM_007874912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NP35"/>
    <dbReference type="STRING" id="1069680.M7NP35"/>
    <dbReference type="GeneID" id="19894884"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01187"/>
    <dbReference type="eggNOG" id="KOG1640">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044409_0_1_1"/>
    <dbReference type="OMA" id="RFYETNF"/>
    <dbReference type="OrthoDB" id="541710at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003865">
        <property type="term" value="F:3-oxo-5-alpha-steroid 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160198">
        <property type="term" value="F:polyprenal reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102389">
        <property type="term" value="F:polyprenol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016095">
        <property type="term" value="P:polyprenol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039698">
        <property type="entry name" value="Dfg10/SRD5A3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14624">
        <property type="entry name" value="DFG10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14624:SF0">
        <property type="entry name" value="POLYPRENOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="169"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR10473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="288" mass="34217" checksum="6C75C5095C21E87E" modified="2013-05-29" version="1">MYDAVVFCRMYFAFLITGLLTVRIIPSTRRWLCYGKTLDAINYKGKSRWSIFYLMVPKKWFIHFYIISILSTCFWTVELYFCRFYNKCDWIVYLSDDKTQSLCEVYICLLFIGLHGIRRFYECFVIQKYSDSQMWIGHYLLGLTYYLFCNISMWCEGGGNLQNLVFDFRHISSIRIFFSILFYSFFSWMQHSSHITLSKLRILPNSPKYSLPTSGCFKYLICPHYTAEIGIYFSLVVLTRAQNKTILLIFIWVILVLTISASQTYAWRLKTFGMNASHSPWIIFPGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPA8</accession>
    <name>M7NPA8_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">mRNA surveillance protein pelota</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PNEG_02440</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">B123</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874448.1">
        <property type="nucleotide sequence ID" value="XM_007876257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPA8"/>
    <dbReference type="STRING" id="1069680.M7NPA8"/>
    <dbReference type="GeneID" id="19896133"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02440"/>
    <dbReference type="eggNOG" id="KOG2869">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095952_0_0_1"/>
    <dbReference type="OMA" id="LKMIILC"/>
    <dbReference type="OrthoDB" id="10249111at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990533">
        <property type="term" value="C:Dom34-Hbs1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000004">
        <property type="entry name" value="Protein DOM34 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000008">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="entry name" value="Pelota, domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058547">
        <property type="entry name" value="Pelota_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="TF_pelota"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00111">
        <property type="entry name" value="pelota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PELOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853:SF0">
        <property type="entry name" value="PROTEIN PELOTA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26356">
        <property type="entry name" value="Pelota_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="Dom34/Pelota N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pelota N-terminal" evidence="12">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="eRF1" evidence="10">
        <location>
            <begin position="42"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="eRF1" evidence="11">
        <location>
            <begin position="176"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF26356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMR09096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="282" mass="32303" checksum="C8F0260C32531FE0" modified="2013-05-29" version="1">MGSYHTLDLKLHSNFTLTKQEWDSIALERLDEACDPNKRAEIGAVVLQEGLANVCLITEYMTILRQRIEIQIPRKRKDNASDYQKGINKFCETVMQAILRSFDFTNLKVVLVASPGFISETLIKYIFDEAVKTDNKTLLQSRSKFLRLHCSSGHMHSLDEVLKSPNISTKLADTKFVQETTALDRFYKILHNDEEKAWYGIKEVSWAIECKAVETLLISDMLFRSNNINERQYYVKLVETVKQYGGKVLIFSSLHESGIQLNQLTGIAAILTFPINMVKNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPB1</accession>
    <name>M7NPB1_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein transport protein SEC31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein transport protein sec31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PNEG_02712</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR08931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874737.1">
        <property type="nucleotide sequence ID" value="XM_007876546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPB1"/>
    <dbReference type="STRING" id="1069680.M7NPB1"/>
    <dbReference type="GeneID" id="19896403"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02712"/>
    <dbReference type="eggNOG" id="KOG0307">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003033_2_0_1"/>
    <dbReference type="OMA" id="WLERPCG"/>
    <dbReference type="OrthoDB" id="542917at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009917">
        <property type="entry name" value="SRA1/Sec31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF11">
        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07304">
        <property type="entry name" value="SRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7 15" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="121"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="264"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="SRA1/Sec31" evidence="17">
        <location>
            <begin position="1183"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1054"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1054"/>
            <end position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMR08931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="1263" mass="142719" checksum="4F8CFF803ACD0302" modified="2013-05-29" version="1">MVKLREIQRTATFAWSPCEEGTWLATGTIPGVIDSGFSDTMDLELWKIDLMDWSSESFELTKANYVTSSGTRFNDIAWGSVVEGRKSGIIAGAMENGALNLWDVDLIRSGASCNESLVAQNTTHNGVIKSLDFNTTQTNLLASAGENGEIWIWDMESPTKPYSSGQKSNQLGEIQSIVFNKDQKVPYILATAGNTGVTSVWDLRAKKAIVNLQFPGVGGGKKGMSSVMWHPNFATKIITASEEDALPVILMWDLRNSHAPEKILSGHEAGVLSISWCKQDSGLFLSCGKDNRTLCWDPFSAELIGEFPRSNNWVFRVSWSLKNPDVIANASYDGKIIIQTIQTTQTLKAENRTDLSLNISNADFFDNIPSCLRSHEPPLLLKKPPKWLRRSCGVVFGFGGKLIVFGNNKTSGLSSVKIMNAIEELNIAEELNIIEDANNFEEVLKKNEIKTYCQKKIQETNDPLQRRIWEILFILLHEDFRDKFVDFLGFKKYNIESEVLDKVREISISKKTKEITDDQETVKSTEENLENLFKKHEANADFFQFKTSSSEKNIFSHLPALNEPFSIFKDSDSELDKVITKSIFLGQFDKAVDLCLQEDRLSDALIFSFCGGKECQRRAQRAYFRKFNNIPYIRLLSSIIEENLWDVALNTDLEDWKEALVIICTFSKSENFSELCDALGDRIDTKFRSKNTDLELRDQAVLCYLMGTKLGKLINIWNEEFQEKKISIFKHIETDNNSNISPYFLHTKLLQDFIEKIGVFKQIIKSDHIEKSINPNTLSVLYKKYEDYANIMASQGNFIIAQKYLNLLPDSYKDSIAAKERINKILNVSQHSNTVKGLNTSQQFSHTTSLPQRPVLNPYTTHLYTSQTYNSYTPNMDMSNQQANLRPTNNHPQLQQKQPSYATCPTPTAYVNISSRHKDIPSWNDAPIINVHKKVVPSSSHISTPFSQNTCQNEQNIINKKSDQFPPQKQTFIPPPPMTGQKYQGFSTQSVQSNISGPYNLHPSTQVNNLSTKNNQNVPETHLSGLNIYGTGPSNPYIPIPNVYPIITGYSKQSQKTENLPSPNIEQHESTTRHNPLAESYTSQAKALYSPQEQTVSPVQVSSNLQALSNPQIPLNLQAPPKNDSTKIQQNNTTSNLFKTTALQNSKYPPGDRSHIPLQLRPIFEGLSSEMEQVKLYAPPAFKRQVQDTERRLNILFDLLNNNYGLSKELLDDMKILVEAMLAKNYQIALNIHINLITTKTEECGHWMVGVKRLLEMSRSIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPB5</accession>
    <name>M7NPB5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ERCC4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PNEG_01259</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">B123</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EME1/MMS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873182.1">
        <property type="nucleotide sequence ID" value="XM_007874991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPB5"/>
    <dbReference type="STRING" id="1069680.M7NPB5"/>
    <dbReference type="GeneID" id="19894956"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01259"/>
    <dbReference type="eggNOG" id="ENOG502R8ER">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_556822_0_0_1"/>
    <dbReference type="OMA" id="EEIPRCT"/>
    <dbReference type="OrthoDB" id="343092at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20085">
        <property type="entry name" value="XPF_nuclease_Mms4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033310">
        <property type="entry name" value="Mms4/EME1/EME2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047521">
        <property type="entry name" value="XPF_nuclease_EME1_ascomycetes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077:SF5">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MMS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077">
        <property type="entry name" value="EME1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="14">
        <location>
            <begin position="196"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMR10553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="490" mass="55728" checksum="540EDBD558DD7279" modified="2013-05-29" version="1">MANKDVKIAMDSHVPVILINDSPECQKLSLISSKNSVFIEDPSKFNQEKDRYSTVDIDSGTVLKEMDLDDDYSIIELSSSPSFNTQDIAKSSLMDRNPNECSEVKDYYNTLSILSTVDDFSLNIMKSTSMMDSKSNSNDSKSSCDLRNDNNLTNHVVIDQKILENTRKRVEKKRISTLKSVNKLKTSKKECIKEMIVNVDTNILSSSMGPILSGLLENASCEYTEWSSPIPNLIFWKRKVIAEYDENLGYFVPVPETIRSEKFILVYIKASELLKLESDSCVDELVKRLTDEFPDLKIIFMIESIDTLFKKIKNDRNRRYVDAMRTTIETKNSENIFIPSEEIEEKIENILLRLQLIHNVFIVNTSSVENSAEWIFILTGDISTIPYKRMKLELSTSFCMESGQIKTGSDVKDTYTKLLQTIYKVTPQIANIIVEKYPKISDLVSAFRENGPDALTDLTIGKLTKRKIGRVLSKRIFHAFMTSDSAASAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPJ8</accession>
    <name>M7NPJ8_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_02522</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the formin homology family. BNI1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000011">
        <property type="protein sequence ID" value="EMR09182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874532.1">
        <property type="nucleotide sequence ID" value="XM_007876341.1"/>
    </dbReference>
    <dbReference type="STRING" id="1069680.M7NPJ8"/>
    <dbReference type="GeneID" id="19896214"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02522"/>
    <dbReference type="eggNOG" id="KOG1922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001313_1_0_1"/>
    <dbReference type="OMA" id="NHYWKAR"/>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904498">
        <property type="term" value="P:protein localization to mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.2220:FF:000006">
        <property type="entry name" value="Cytokinesis protein sepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000898">
        <property type="entry name" value="Formin BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051661">
        <property type="entry name" value="Actin_filament_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014767">
        <property type="entry name" value="DAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102:SF2">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51231">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="6">
        <location>
            <begin position="163"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="7">
        <location>
            <begin position="1020"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="domain" description="DAD" evidence="5">
        <location>
            <begin position="1448"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="101"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="727"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="869"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="618"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="685"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1398"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="869"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="886"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="903"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR09182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1615" mass="182746" checksum="FE3D738CB4B645EE" modified="2013-05-29" version="1">MQEKTSRKIKTPTESSQQQFFGKRIREILNKDKKTDDSLSSVPYGEIMVSGTRPIILGNTSSKTILEATDGSSIVSLNSGSAPSGSYSNVSMSCGSKAITSHKNASCRESNASVGSSSGPSRRNISDDQHSVSSSRSSYSEDFQRLGLFSYNAIGSNGEFSFERPKDHSIIEHMFVELLNMKNIPFDSRGKMMNWSASKKWQMIYQDALQEYQNRKKWISSHGYEADKGSPQWFVRKIVNNTIKIKQLSTLSVSLRTQPISWVRSFIKCQGQIALTNVLSHITQRVNKRDDDILKELEILKCLKSLLNNTYGADDAIEHQSCVNSVASSLLSPHLPSRKLAAEVLTFICHWDKPNGHSVVLASLDHLRSYLGELGRFDAWMRVLELTVDGRGKMGSLVGASDEIRRGGMGVENILMEYALANLFLINSLCNGADDVRERLHIRSQFKACGYQRMALKMQQFNYDIIDRQLEKFENDEALDYEDLFEKDAQDEIKNLDNPLELMGLIWKRIEGTRAQDFFLSTLQHLLLIRDDGENRSKLFQLIDAILTYVVMDHRMAGMDPTHALNFSIQGVVSKLHTDEEARKAVEEAREARMIAERTAIERDTMAAEIAAGANGLVGKLKKELMEQAEALETQRRQNAILRNEVEELQRVHMLQLQKSEIETRELYMIIRDTNPEIWENSKGIVDRKALMDKLEKQLERKKTEYKLEGKAWQNITSSKRLKELRSRMESLQLSPKDIGSQKNDEDQILQSQDTHEKPSFFGSTRAKPSKLSPRTIKHHSRSSVRVISTNYVHDTKRLGGVQQIVQYKKEHVEESTDYVFMDELSSKLRHLNSNEDTDDIIGHVIFSETQTESTDLDNLAWNNDNVSSCSQTLSSGTPLSDEKVTQNIPSETSTDISLSLPSLPPPPPPPPPPPPPPPPPLPPPLPSLCPNMAASGFINSQNALDISPLPPPPPPPPVFLTNNPQMKTCNDSATSVLNGVSSQPQISLEKSEVVQEIPLHSGEVGRTGLPFINPEIKTQVMMMRSKKKLKQMHWDKLDTGVEYTLWAQMKLDPNALAGVLSKKGILDEIERAFAMKETKIINTRTSRKKEFLSSDLQQRFGINFHKFSNLSVSEIVIKILHCDMDTMDLIDFLSDDKLLGIEQLKAGLEPYRTDWSSGGTRINPEKNIEELSRWDQIYLYLFIDLGHYWQRRMMALKMKINLERSYTDLVRDIKCIETAALAIKGSQNFRELLDVILHVGNYMNDSGKQAYGFKMTTLQRLPMTKDDRNSLTFLHLVEKVVRTNFPQLEEFLDDFKDVGLAAKINLDHINSECKMLVDNVFSIERACNTGSLSDASVFHPEDKILNIILPFLPEAKKKVGYIQDHFNSMETTFENVLRYFGEEPSDSQAKSTFFRKFEMFSNDYRKAQKENLEFEEESHRQLLRRRALNAASKSNILDTAMDENAKSDTAIMDNLLEKLRVAPAESRKVRRRLVAKNFQITSSHYSDNHNITKNDSTSSFSSSPVNELAIKMRDVEAEYNSSISKMSLVQSSTSTMSPVSVPSGTMSNKDVAAKAQSMLEGLRCGKISRVPPVLKDNSSVNGLDYSINKDQSQDKMNDTNQYLNHKLENEMEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPN2</accession>
    <name>M7NPN2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PNEG_02832</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000007">
        <property type="protein sequence ID" value="EMR09061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874867.1">
        <property type="nucleotide sequence ID" value="XM_007876676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPN2"/>
    <dbReference type="STRING" id="1069680.M7NPN2"/>
    <dbReference type="GeneID" id="19896521"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02832"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="OMA" id="FTWFRYA"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05327">
        <property type="entry name" value="retinol-DH_like_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMR09061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="35664" checksum="50BDDA8A7CC091DB" modified="2013-05-29" version="1">MFNDLNWISSQLPDLSDKIAIVTGANSGIGFVTARELLRKNAKVYIASRCKKRTEEAIKNIKETLTNPNVFWLEYDACDFNSVKNAVSTFINKESKLHILVNNAGVMAPPYSETKNGFEIQFQTNYLSHYLFTRLLLPVMKKTLENEKEGAVRIINVSSRAHSMSLKNITYNDLNMKSFWYCPELILRWLRYAQSKLALILFTKSIYQKYSKDGIYVISVHPGVVRTGLFRYTKFLRSFLIFSRLFISKEEGAITQIFAAASNDIVEKKLNGEYLVPYCKKAIPFGNFSLEASEKLWEFSEKELKNKGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M7NPZ7</accession>
    <name>M7NPZ7_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_02287</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874281.1">
        <property type="nucleotide sequence ID" value="XM_007876090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NPZ7"/>
    <dbReference type="GeneID" id="19895980"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02287"/>
    <dbReference type="HOGENOM" id="CLU_2292880_0_0_1"/>
    <dbReference type="OrthoDB" id="5345331at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005351">
        <property type="entry name" value="ASTER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28038">
        <property type="entry name" value="ADL329WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28038:SF1">
        <property type="entry name" value="ADL329WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03669">
        <property type="entry name" value="ASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR09332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="101" mass="11378" checksum="372E28D2D9C6EE5E" modified="2013-05-29" version="1">MTQSKDPRREDLIRKFTPIEVEEELDFTNILVSILSFSSMIFKNKWFAWASLVGTISGFLDGKAQTSISQGNLTNIIMSGVAFVVMYTPIIFPQKISESPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQE5</accession>
    <name>M7NQE5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02266</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874255.1">
        <property type="nucleotide sequence ID" value="XM_007876064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQE5"/>
    <dbReference type="STRING" id="1069680.M7NQE5"/>
    <dbReference type="GeneID" id="19895959"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02266"/>
    <dbReference type="eggNOG" id="KOG0147">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020551_4_1_1"/>
    <dbReference type="OMA" id="GRDNDKG"/>
    <dbReference type="OrthoDB" id="5411533at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990446">
        <property type="term" value="F:U1 snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12283">
        <property type="entry name" value="RRM1_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12284">
        <property type="entry name" value="RRM2_RBM23_RBM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000291">
        <property type="entry name" value="CC1-like family splicing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000172">
        <property type="entry name" value="RNA splicing factor Pad-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029123">
        <property type="entry name" value="RBM39_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006509">
        <property type="entry name" value="RBM39_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01622">
        <property type="entry name" value="SF-CC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48036">
        <property type="entry name" value="SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15519">
        <property type="entry name" value="RBM39linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="24"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="125"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="294"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="391" mass="43968" checksum="50B6E3A0AB9741C2" modified="2013-05-29" version="1">MHFFKQRMNREESPKLTEDERDRRTVFVQQLAARLRTRELIAFFEKVGPVRDAQVVKDRVSGRSKGVGYVEFRDEESVHKAINMTGQRLLGIPIIVQLTEAEKNRQAKADAMITTGGRQSDAPFHRLYVGNIHFNLTEDDLRQIFEPFGELEFVQLQKEHDTGRSRGYGFVQYRDPAQARDALEKMNGFELAGRAIRVGLGNDKFIPETSSVLARFSGFTGSAFENKSRGGTERIGGPRDGSSSISLDDNEAGGVSFNNISRDALMKKLAREEGKESIGVIPPKPMPSVQMTSRCVLLKNMFNPQEESGDNWVRELEEDVKAECENKYGKVLHIHVEENSPGEVYIKFDNVVAGERAIQGLNGRWFGGRTVSASFLIDAVYTAKFPKTKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQK0</accession>
    <name>M7NQK0_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_02324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874325.1">
        <property type="nucleotide sequence ID" value="XM_007876134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQK0"/>
    <dbReference type="STRING" id="1069680.M7NQK0"/>
    <dbReference type="GeneID" id="19896017"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02324"/>
    <dbReference type="eggNOG" id="KOG2688">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031567_3_0_1"/>
    <dbReference type="OMA" id="PQLCSNI"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF8">
        <property type="entry name" value="NUCLEAR MRNA EXPORT PROTEIN THP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR09376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="49836" checksum="A91CA2491EA1198A" modified="2013-05-29" version="1">MNIQEFFNRLSRVYEKSNSVDLLDIFVFDGSNGSVDLLKKELCQLEITDISRECEWRFGSWKIFSEFVMAYLEFLKNVVFSDIEIFYKLYYQVFLQLITTFSHSNTTWLTPLVKYMSLILTKVSIQLDNLTHDPHQTATSETSRAIFRLFNIILSDRHPLPDSKKVCSLYIANLLLRLYFKLNQIRLCQTISSNITSSGIEFSLYPISERIGFSYYLGRYNLYQQQITRARGHLLFAFDNCLTANYKNKRLILIYLTTASIILGIFPSAELLSKYHLSQYFSPVIFCLIKGDHKGFSDHINHDAIRSWLLKKQIFLTIRDHCEILLWRSLFRRSFLITRDPLQKPPRVKLEDLLIAAKWAKNDDTYDLLDVECICISLLDQNYLQAYILHASKLLVLKRDDTHGFQKISNVKALQAAHDDDVTFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQM6</accession>
    <name>M7NQM6_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Vesicular-fusion protein SEC18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PNEG_02351</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000013">
        <property type="protein sequence ID" value="EMR09406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007874355.1">
        <property type="nucleotide sequence ID" value="XM_007876164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQM6"/>
    <dbReference type="STRING" id="1069680.M7NQM6"/>
    <dbReference type="GeneID" id="19896044"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02351"/>
    <dbReference type="eggNOG" id="KOG0741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008037_2_0_1"/>
    <dbReference type="OMA" id="CFDNEIA"/>
    <dbReference type="OrthoDB" id="9982946at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19504">
        <property type="entry name" value="RecA-like_NSF-SEC18_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000026">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000166">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000012">
        <property type="entry name" value="Vesicle-fusing ATPase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000187">
        <property type="entry name" value="Vesicular-fusion ATPase SEC18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039812">
        <property type="entry name" value="Vesicle-fus_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078:SF3">
        <property type="entry name" value="VESICLE-FUSING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078">
        <property type="entry name" value="VESICULAR-FUSION PROTEIN NSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="292"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="573"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMR09406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="780" mass="87657" checksum="971C7862D00575F9" modified="2013-05-29" version="1">MNKNKPAQEYKDRNFSNIFNDNRQPNNVLSNYSLNKEKKQGGIYTIVKIPKTQGEQIELTNCLAVSPYDFKDNTYVICDDFYIFSTKVVTEMKQGHIGASLIQRDWAQWSLGQSVSVTSYDPFVNDIMYIESMDLEIGFVPGFRTTEEQFDGEIMAKWFSKCFQNQILTLEQKLIFDFKSYNIKAIVKNIKCIKVSISEKKKTEDMEISSNSYTRGILTLHTSINIYKTGNSNIRIKASTRRPNANSIIQPNFKFEDMGIGGLDSEFSAIFRRAFASRIFPSGLVDKLGIQHVKGILLYGPPGTGKTLMARQIGKMLNAREPKIVNGPEILNKFVGQSEENIRKLFFDAEKEYKEKGEDSGLHIIIFDELDAICKQRGSRNDGTGVGDSIVNQLLTKLDGVDVLNNILIIGMTNRFDMIDEALLRPGRLEVHMEISLPDEHGRKQILKIHTSKMKKNEVIDRDVDLDELATLTKNFSGAEIGGLIKSASSFAFNRHVKVGTVAGVSEDVENLKVNRMDFINALKEVKPAFGVNEEELEQSIRNGIIKFSSYIENILNEGKLFVEQVRKSERTPLISLLLHGPPGSGKTALAATIALASEFPFIKLISPESMIGFSENAKVSALGKIFNDSYKSPLSVIVVDNIERLLDWVPIGPRFSNTVLQTLMILFRKRPPKSRRLLIIVTSSEKTVLSHMSILSSFDADIPVPNVSSLHELDTVLRHLEILSDTERNLALKSIREIHPSEEISIGISRIISIVETARQDEECAEKLVELIVKTITSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NQU3</accession>
    <name>M7NQU3_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_00692</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase VIIa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872590.1">
        <property type="nucleotide sequence ID" value="XM_007874399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NQU3"/>
    <dbReference type="STRING" id="1069680.M7NQU3"/>
    <dbReference type="GeneID" id="19894390"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00692"/>
    <dbReference type="HOGENOM" id="CLU_169147_3_0_1"/>
    <dbReference type="OrthoDB" id="5511599at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.91.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039297">
        <property type="entry name" value="COX7a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036539">
        <property type="entry name" value="Cyt_c_oxidase_su7a_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02238">
        <property type="entry name" value="COX7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81419">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR11093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="64" mass="7632" checksum="C8549FD06C792720" modified="2013-05-29" version="1">MPRKNKVPYYQKLFQENTHLPVYFRTPRSKLMIYPYLALWGLSLVGSLWGVMNLVRVFSLINKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M7NR09</accession>
    <name>M7NR09_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA wybutosine-synthesizing protein 2</fullName>
            <shortName evidence="6">tRNA-yW-synthesizing protein 2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_00754</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36355"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.5.1.114"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872655.1">
        <property type="nucleotide sequence ID" value="XM_007874464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NR09"/>
    <dbReference type="STRING" id="1069680.M7NR09"/>
    <dbReference type="GeneID" id="19894452"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00754"/>
    <dbReference type="eggNOG" id="KOG1227">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023588_1_0_1"/>
    <dbReference type="OMA" id="NAFWVHC"/>
    <dbReference type="OrthoDB" id="2387925at2759"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102522">
        <property type="term" value="F:tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026274">
        <property type="entry name" value="tRNA_wybutosine_synth_prot_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF25">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038972">
        <property type="entry name" value="Trm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="7">
        <location>
            <begin position="79"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR038972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMR11158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="350" mass="40539" checksum="74CD04588A01434B" modified="2013-05-29" version="1">MKEEIQEIFEESEYNTSGVEKMNEKYKIDEKIASFNIPSRWTIYGNMLLFSFNSFSSSQWTLFFSKLEISDKTLFYKGISEIFGVTHLALNGKIPPNDEMRIPEKFVPLYGDFGFKVKGNPTEKDFKEAFWASTKQNGIFQVWSPMYTMFSRGNIKEKARILMLPGVKDAIIADLYAGIGYFAFFYLKAKAKHVFCWEINPWSVEGLCRGAKLNNFKYEKVSNLDKNYENNQLIIFENNNILASKQLAGKIKNIRHINLGLLPSSEDSWLTCTKILDSEVGGWIHVHAAVYNKEIYNWTNKCKDKFTSLFKNNWKIQIQHVENVKQISPKKLHIVVDLLCIPKNKISPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M7NR13</accession>
    <name>M7NR13_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein sym1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PNEG_02137</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000012">
        <property type="protein sequence ID" value="EMR09551.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019613301.1">
        <property type="nucleotide sequence ID" value="XM_019757739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NR13"/>
    <dbReference type="STRING" id="1069680.M7NR13"/>
    <dbReference type="GeneID" id="19895830"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_02137"/>
    <dbReference type="eggNOG" id="KOG1944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1310586_0_0_1"/>
    <dbReference type="OMA" id="FRVMPIQ"/>
    <dbReference type="OrthoDB" id="10267969at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF50">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YOR292C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMR09551.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="28700" checksum="EC8055C23DCBD40B" modified="2016-03-16" version="2">MSEILYRKNILKFPLLNIFIIILISFILITIFLRYNEFYQKYPILTLSVTNSLLGGISNMSAQTISAIHSRLRRINSFNLKTKKVEMENISLDNPDKSYTTFYIPSAFRFSQLIRFMSYNFLTTPIQLWWYSFLDHLSTISRISNTAELIKRILMDQFLFTPISLTFYLVFMSLTEELSKKKLKNKFNQGFFSILKANYCIWPAVQLINFKYIPLKYQIPFLNSISIFWTIYLTICDLKTSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M7NR20</accession>
    <name>M7NR20_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein arginine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PNEG_00762</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000002">
        <property type="protein sequence ID" value="EMR11168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872664.1">
        <property type="nucleotide sequence ID" value="XM_007874473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NR20"/>
    <dbReference type="STRING" id="1069680.M7NR20"/>
    <dbReference type="GeneID" id="19894460"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00762"/>
    <dbReference type="eggNOG" id="KOG0822">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010247_2_1_1"/>
    <dbReference type="OMA" id="IKYAWYE"/>
    <dbReference type="OrthoDB" id="1368803at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071521">
        <property type="term" value="C:Cdc42 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990463">
        <property type="term" value="C:lateral cortical node"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071470">
        <property type="term" value="P:cellular response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061246">
        <property type="term" value="P:establishment or maintenance of bipolar cell polarity regulating cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903359">
        <property type="term" value="P:lateral cortical node assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903360">
        <property type="term" value="P:protein localization to lateral cortical node"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000100">
        <property type="term" value="P:regulation of establishment or maintenance of bipolar cell polarity regulating cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007857">
        <property type="entry name" value="Arg_MeTrfase_PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035075">
        <property type="entry name" value="PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035248">
        <property type="entry name" value="PRMT5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035247">
        <property type="entry name" value="PRMT5_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738:SF0">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05185">
        <property type="entry name" value="PRMT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17286">
        <property type="entry name" value="PRMT5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17285">
        <property type="entry name" value="PRMT5_TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015894">
        <property type="entry name" value="Skb1_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRMT5 TIM barrel" evidence="10">
        <location>
            <begin position="39"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 arginine-N-methyltransferase" evidence="9">
        <location>
            <begin position="265"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 oligomerisation" evidence="11">
        <location>
            <begin position="431"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="300"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="382"/>
            <end position="383"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for specifying symmetric addition of methyl groups" evidence="7">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR015894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMR11168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="630" mass="73347" checksum="C4FC6DCE2641B3C5" modified="2013-05-29" version="1">MTNIQQNKLLIGLECSSIFQKFEALENGYDFIGINVLNKTQENDYFEKYIGLSDKDVNIHVEDILDISAFALSYIQLDLYDEQILKKSTQILYDEVQYVSYIGISHFVLPLFTQKTLIPQYARMINHLFSLSTYIHFYIFFSMDDLVDPLELWDIWNTIRILCGYNNRLLLAFKIGNKLPELTAITRWFAEPIGLLIINSNIFVSNSDGNLILPQAHQTFYTKLIKFKPNVLLQISDDISLSNNSSVYYQYLRHLENINPTTTIEKFANGYQDYLQIPLQPLADNLESITYEVFEKDLVKYDQYELSIRRALMDRSKLNEPIYIAIVGAGRGPLISRSLKAAESADRKIIIYAIEKNPNAFITLEHRNRYEWNNNIHLIHIDMRLWKPPVLIDIIISELLGSFGDNELSPECLDGVQKFLNPKGGIFIPSSYTTYITPIMAPKIYGNILQMKSDAAFEMFYSIWLHSIDYLAKDSENKFQELWKFSHPNPNYYDDNSNFHNTRKSKNTFNIFSRGMLHGFAGYFEAVLYDNIKLSTRPDIIDEKLKDMVSWFPAFFPLKTPLYVPSGSHVDLYFWRQTDSKKVWYEWLAEVYIISSDTQNNEPLHDSNRIKIGMTGIHNYNASFFSISLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRC9</accession>
    <name>M7NRC9_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PNEG_01993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873973.1">
        <property type="nucleotide sequence ID" value="XM_007875782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRC9"/>
    <dbReference type="GeneID" id="19895687"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01993"/>
    <dbReference type="HOGENOM" id="CLU_1687423_0_0_1"/>
    <dbReference type="OrthoDB" id="10626675at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMR09812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="156" mass="18855" checksum="A07A192C0182DB6C" modified="2013-05-29" version="1">MKYEENISKNSIIKSEINLSLHKTRELVTSWMNKSENKLDFKEEKEDINSEDEELFRSRIQKRQVYDTELSEEKALLRKKLSLFKSKKQKDEEEKVEIYDDSDEFESKSKYIEKISLIKQSKDFSYGDNDKKRANSFFDIYKSKKKKKHKSNQKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRM4</accession>
    <name>M7NRM4_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PNEG_00417</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872294.1">
        <property type="nucleotide sequence ID" value="XM_007874103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRM4"/>
    <dbReference type="STRING" id="1069680.M7NRM4"/>
    <dbReference type="GeneID" id="19894115"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00417"/>
    <dbReference type="eggNOG" id="ENOG502S5MV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_674585_0_0_1"/>
    <dbReference type="OMA" id="PTEYSKD"/>
    <dbReference type="OrthoDB" id="429427at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012890">
        <property type="entry name" value="GCFC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028211">
        <property type="entry name" value="Ntr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214">
        <property type="entry name" value="GC-RICH SEQUENCE DNA-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214:SF0">
        <property type="entry name" value="LD29489P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15458">
        <property type="entry name" value="NTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMR11393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="408" mass="47756" checksum="01B55FDA804E83C4" modified="2013-05-29" version="1">MAYQIRRLKARITRIHTQDEDSDELETPTSSPFSNIQYDREKSNSQDLNSKFLEKNPRKESKNFRLSFGFEERDEMNIYEQDKEDFVKKKNHLKQDFLEEQGIKGSPLIHKVLESHEKTSKVTPKYNSDYLSKLRLSTPSTPKEFCNIYKENVDIDNLHITEKNSQLSVKIPKILDEGIVKALKERRLEKREQNRLNNVYIPLEDDDQIILYSKSNESRLQREDDIFDNDGIEGLREYVDDRIILSKDLKKTQDKQKYIEMKNSIKNIQDSDIDEDASEEEESKWEQTQIRKGVYGSKLINMNLSPSKKNQPIPLEIQTFENSINRLKTILSSMKSEKDLMLSQIKTLTSEKEDIFKKEAIIKESLQKASQEYSNIQLKISETNSPFRGLDSMTSYSLKQSPLSQTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRR2</accession>
    <name>M7NRR2_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Acyl-CoA desaturase</fullName>
            <ecNumber evidence="16">1.14.19.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PNEG_01960</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">B123</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:19721"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="EC" id="1.14.19.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="16">Expected to bind 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="16"/>
    <dbReference type="EMBL" id="AFWA02000009">
        <property type="protein sequence ID" value="EMR09776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873937.1">
        <property type="nucleotide sequence ID" value="XM_007875746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRR2"/>
    <dbReference type="STRING" id="1069680.M7NRR2"/>
    <dbReference type="GeneID" id="19895654"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01960"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027359_3_2_1"/>
    <dbReference type="OMA" id="WAHKSYN"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000004">
        <property type="entry name" value="Acyl-CoA desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001522">
        <property type="entry name" value="FADS-1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000345">
        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00476">
        <property type="entry name" value="FATTY_ACID_DESATUR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="15 16" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 16" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16" id="KW-0408">Iron</keyword>
    <keyword evidence="4 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="324"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMR09776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="437" mass="50639" checksum="FAEF312664B39624" modified="2013-05-29" version="1">MENKVNSYNIPDEPLSLKNWYRKINWINSILLIVPPILGIYGFFTTPLKLNTFIWSLIYYFMTGFGITAGYHRLWSHRSYNATLFLRILMALLGGGAVEGSILWWGRNHRAHHRYTDTDKDPYSVSKGLFYSHFGWMIVRQNPKKVGYSDISDLKADSVVMWQHKNYLKIMIIMGFLFPMFVAGLGWKDWRGGFFFSGICRLVFVQHATFCVNSLAHWIGSQPFDDRHSPRDHVFTALATLGEGYHNFHHQFPMDYRNAILWYQYDPTKWLIILFKKIGLAYNLKEFPSNEVQKGILQQKQKKLDRWKAKLDWGTPLDQLPIIEFEEFQKQAKTRPLILIAGIVHDVEKFIDSHPGGRALITSAIGKDATAIFNGGVYNHSNGAHNLLSTMRVAIVRGGMEVEIWKQKYKNLDHIITNNTQITRISNLTQRISFTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M7NRR3</accession>
    <name>M7NRR3_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein eL24-related N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PNEG_00457</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">B123</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872339.1">
        <property type="nucleotide sequence ID" value="XM_007874148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NRR3"/>
    <dbReference type="STRING" id="1069680.M7NRR3"/>
    <dbReference type="GeneID" id="19894155"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00457"/>
    <dbReference type="eggNOG" id="KOG1722">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106411_0_0_1"/>
    <dbReference type="OMA" id="PGHGKKM"/>
    <dbReference type="OrthoDB" id="1727108at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023442">
        <property type="entry name" value="Ribosomal_eL24_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01073">
        <property type="entry name" value="RIBOSOMAL_L24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL24-related N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMR11438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="159" mass="18475" checksum="06BDF6D808271DD6" modified="2013-05-29" version="1">MKIEVDSFGGNKIYPGKGKIYVRGDNKVFRFFCRKTGSLFIQRKNPRKITWTILYRRMHKKGITEEVAKKRTRRTLKFQRAIVGASLEVIREKQNQREEVRMEARRKAIKDGKEKKQAQENLKRANKAKLAINARGSVVSKVSKQQAKGARLKILSTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M7NS08</accession>
    <name>M7NS08_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PNEG_00548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000001">
        <property type="protein sequence ID" value="EMR11538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872439.1">
        <property type="nucleotide sequence ID" value="XM_007874248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NS08"/>
    <dbReference type="STRING" id="1069680.M7NS08"/>
    <dbReference type="GeneID" id="19894246"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00548"/>
    <dbReference type="HOGENOM" id="CLU_937249_0_0_1"/>
    <dbReference type="OrthoDB" id="2420947at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025212">
        <property type="entry name" value="CAD_CENP-Q"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13094">
        <property type="entry name" value="CENP-Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="134"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMR11538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="297" mass="35459" checksum="BA85B75CD40C030C" modified="2013-05-29" version="1">MVENEDNIFQGFHAKQVDLTKNLKNKEIFQKHSSHLKSDIQRQRKKQPLEKFHQDHTIPYLRQQIRRIPRSVINRRWTQISESSLIQIVEILKDIQRSVIMSIRHKTRRMDAQRNLNIMINKIRDRISRLLVPSSKEQYNYEKLKEKNQELESILISNLEQISRLEKALNQEKYLLSKEEANFRELTKNAQYDEKSKKQIKRLHPLLRLQDDQIEPKFSYTQINLNENNSLAFDILSDKSFITLERQIKQYVNNMKSSSTRAGKIMQLSQKAQVTLLKILTSYDHFLSRRISIDTCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSI7</accession>
    <name>M7NSI7_PNEMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA phosphorothioation-dependent restriction protein DptG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PNEG_00147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000005">
        <property type="protein sequence ID" value="EMR11713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007872008.1">
        <property type="nucleotide sequence ID" value="XM_007873817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSI7"/>
    <dbReference type="STRING" id="1069680.M7NSI7"/>
    <dbReference type="GeneID" id="19893845"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_00147"/>
    <dbReference type="eggNOG" id="KOG4699">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066294_0_0_1"/>
    <dbReference type="OMA" id="DYWQRYQ"/>
    <dbReference type="OrthoDB" id="73168at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018624">
        <property type="entry name" value="Sec66"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229:SF1">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09802">
        <property type="entry name" value="Sec66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="112"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMR11713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <sequence length="207" mass="24474" checksum="F9BCB9035FA4ECC3" modified="2013-05-29" version="1">MSSVPFYLPILYLSILLGSLSLFSFFYTKYKRLKISPLEEWFSSNISRDIYFSLLHLSDSVPTNILKAALLERAKENLKRIHELRLKKTVLNQAVQRGLLSNDLWKQFRLLEKELELEVMDISREAQSFRKDWGQLIFQTANEMVLNEQLRQNIMQIRDMAEKEGKRYEKLKKISEKVKEEQKRIAESELLKEVNSLSSSQKKKTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M7NSX7</accession>
    <name>M7NSX7_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cell division control protein 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PNEG_01634</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">B123</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000004">
        <property type="protein sequence ID" value="EMR10382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873591.1">
        <property type="nucleotide sequence ID" value="XM_007875400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NSX7"/>
    <dbReference type="STRING" id="1069680.M7NSX7"/>
    <dbReference type="GeneID" id="19895328"/>
    <dbReference type="VEuPathDB" id="FungiDB:PNEG_01634"/>
    <dbReference type="eggNOG" id="KOG2070">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002632_0_0_1"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000011958">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11883">
        <property type="entry name" value="SH3_Sdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056685">
        <property type="entry name" value="DUF7783"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056686">
        <property type="entry name" value="DUF7784"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25006">
        <property type="entry name" value="DUF7783"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25008">
        <property type="entry name" value="DUF7784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="71"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="8">
        <location>
            <begin position="804"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="7">
        <location>
            <begin position="971"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="714"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="727"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMR10382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1223" mass="141518" checksum="AC769641109DCA99" modified="2013-05-29" version="1">MFDSNVLETDFFVNDNTSPDSQVIIKTISNIIPKDPKSHTTVSLSRKNKTEDFRSMGSRYKTLTGELKYKKRLSLVRAIYDFNLPKLSSLKFVAGDIIEVLNRMENGWWDGVLGDQRGWFPSNYVQHLDENEINEFEEDENNDHDTYNIQIGLEQNMIEENSIEYLHQESQDIKANDHSLRDSIWISDVLNEKPYYPNTEKESSEASFPYFLASNDQFNSNSKKVHKKKSLSLTTDKKLNDLSFLLDMSSVLKSPYFENDITEKMHRIENKEESKGVHLYTFPQRSPSMKGLSPLEAFIISSYEDKLNIVSSSEASLHNEDSSRISDSDDGSSILMPIYYCPLQSSIDSKDDKSTYLNSKALKLIPEELIPSYKKILQNMRQSINDLHKFVELKMKVLFQKLCDSIRITIIYLVHASGMLRIVSILGNSLPTIISISESDFKTIKWYYWRILTALSKLILSTKLASSEWLPENIKSSVLNDAEDIIIIVEEYIKFIVSKNSIYRTPCKFRLGFIKDRQVGGGWRGNGLIVYTKPTVHNNILLELEIQSSDNLTLKPLSQELLSKLNTSLNEIKCLLNYFQKKLLKPSFSDDEKKASIIISDFFIIHETKTILKSIRIFMEMIESVDVTPLEETCGDTYSPTLFDFLNAKQALYDSINTFVLIVQSFPKFINIYNNNPIMSIVNSSRNINCSLQSLMMTIEFLVGEKEIRTKKCSEDPMYSHHRTSSKKLSMSSNISMESDDSKSVLKASPTTPRTKTKLKKIFGDESPFGKCSPQKVFSMLETQNEPIPWFLKYNHEGKIIYDEQGCLKAGTLVGLIEHLTRHDLLDSLFNNTLLLTYRTFTSAENFFNLLVERFMIAPPENLKPHELEIWIEKKQKPVRLRVFNILKIWLESYFMEPMDENSERLLNQIKEFTINILSESISGENLVRIIDKRMKNEDRNYFRKLMLNIGFVAPPILPKNLRRFKLLDLDPLEVARQLTIMESRIYNKIKPIEFLNKAWSKHLCNGIAENIRSMILKSNQITGWVTQTILSQTEVKKRVRILKHFINIADRCRSLNNFSTVTSIISGINSAPIHRLKRTWELVTKKTINTFDSLNKMMDSTKNFSEYRELLRLINPPCVPFLGVYLTDLTFIEDGNPDMIKNSKDFINFSKRIKTAEIIREIQQYQSISYSFQVVPEIQSYLLECLEGMDKLNDMYDLSLGIEPRERDDEKLARLLQESVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M7NTF5</accession>
    <name>M7NTF5_PNEMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PNEG_01268</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Pneumocystis murina (strain B123)</name>
        <name type="common">Mouse pneumocystis pneumonia agent</name>
        <name type="synonym">Pneumocystis carinii f. sp. muris</name>
        <dbReference type="NCBI Taxonomy" id="1069680"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Taphrinomycotina</taxon>
            <taxon>Pneumocystomycetes</taxon>
            <taxon>Pneumocystaceae</taxon>
            <taxon>Pneumocystis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10740" last="10740">
            <title>Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.</title>
            <authorList>
                <person name="Ma L."/>
                <person name="Chen Z."/>
                <person name="Huang D.W."/>
                <person name="Kutty G."/>
                <person name="Ishihara M."/>
                <person name="Wang H."/>
                <person name="Abouelleil A."/>
                <person name="Bishop L."/>
                <person name="Davey E."/>
                <person name="Deng R."/>
                <person name="Deng X."/>
                <person name="Fan L."/>
                <person name="Fantoni G."/>
                <person name="Fitzgerald M."/>
                <person name="Gogineni E."/>
                <person name="Goldberg J.M."/>
                <person name="Handley G."/>
                <person name="Hu X."/>
                <person name="Huber C."/>
                <person name="Jiao X."/>
                <person name="Jones K."/>
                <person name="Levin J.Z."/>
                <person name="Liu Y."/>
                <person name="Macdonald P."/>
                <person name="Melnikov A."/>
                <person name="Raley C."/>
                <person name="Sassi M."/>
                <person name="Sherman B.T."/>
                <person name="Song X."/>
                <person name="Sykes S."/>
                <person name="Tran B."/>
                <person name="Walsh L."/>
                <person name="Xia Y."/>
                <person name="Yang J."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zheng X."/>
                <person name="Stephens R."/>
                <person name="Nusbaum C."/>
                <person name="Birren B.W."/>
                <person name="Azadi P."/>
                <person name="Lempicki R.A."/>
                <person name="Cuomo C.A."/>
                <person name="Kovacs J.A."/>
            </authorList>
            <dbReference type="PubMed" id="26899007"/>
            <dbReference type="DOI" id="10.1038/ncomms10740"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">B123</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AFWA02000006">
        <property type="protein sequence ID" value="EMR10562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007873191.1">
        <property type="nucleotide sequence ID" value="XM_007875000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M7NTF5"/>
    <dbReference type="STRING" id="1069680.M7NTF5"/>
    <dbReference type="GeneID" id="19894965"/>
    <dbReference type="VEuPathDB" id="FungiDB:
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